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PMC:539061 / 31174-32346 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T6041 0-2 PRP denotes We
T6043 3-7 RB denotes next
T6042 8-14 VBD denotes turned
T6044 15-17 IN denotes to
T6045 18-21 DT denotes the
T6046 22-30 NN denotes presence
T6047 31-33 IN denotes of
T6048 34-45 JJ denotes cytoplasmic
T6049 46-51 NN denotes Ajuba
T6050 52-55 IN denotes for
T6051 56-57 DT denotes a
T6053 58-66 JJ denotes possible
T6054 67-78 JJ denotes mechanistic
T6052 79-83 NN denotes link
T6055 84-86 IN denotes to
T6056 87-90 DT denotes the
T6058 91-104 JJ denotes proliferative
T6057 105-113 NN denotes increase
T6059 114-116 IN denotes in
T6060 117-120 PRP$ denotes our
T6062 121-126 NN denotes Snail
T6063 127-129 NN denotes Tg
T6061 130-139 NN denotes epidermis
T6064 139-140 . denotes .
T6065 140-390 sentence denotes In addition to its documented ability to bind α-catenin [10], Ajuba can also associate with growth factor receptor-bound protein-2 (Grb-2)/son of sevenless (Sos), the nucleotide exchange factor for Ras, which is upstream from activation of MAPK [9].
T6066 141-143 IN denotes In
T6068 144-152 NN denotes addition
T6069 153-155 IN denotes to
T6070 156-159 PRP$ denotes its
T6072 160-170 VBN denotes documented
T6071 171-178 NN denotes ability
T6073 179-181 TO denotes to
T6074 182-186 VB denotes bind
T6075 187-188 NN denotes α
T6077 188-189 HYPH denotes -
T6076 189-196 NN denotes catenin
T6078 197-198 -LRB- denotes [
T6079 198-200 CD denotes 10
T6080 200-201 -RRB- denotes ]
T6081 201-203 , denotes ,
T6082 203-208 NN denotes Ajuba
T6083 209-212 MD denotes can
T6084 213-217 RB denotes also
T6067 218-227 VB denotes associate
T6085 228-232 IN denotes with
T6086 233-239 NN denotes growth
T6087 240-246 NN denotes factor
T6088 247-255 NN denotes receptor
T6090 255-256 HYPH denotes -
T6089 256-261 JJ denotes bound
T6091 262-269 NN denotes protein
T6092 269-270 HYPH denotes -
T6093 270-271 CD denotes 2
T6094 272-273 -LRB- denotes (
T6095 273-276 NN denotes Grb
T6096 276-277 HYPH denotes -
T6097 277-278 CD denotes 2
T6098 278-279 -RRB- denotes )
T6099 279-280 HYPH denotes /
T6100 280-283 NN denotes son
T6101 284-286 IN denotes of
T6102 287-296 NN denotes sevenless
T6103 297-298 -LRB- denotes (
T6104 298-301 NN denotes Sos
T6105 301-302 -RRB- denotes )
T6106 302-304 , denotes ,
T6107 304-307 DT denotes the
T6109 308-318 NN denotes nucleotide
T6110 319-327 NN denotes exchange
T6108 328-334 NN denotes factor
T6111 335-338 IN denotes for
T6112 339-342 NN denotes Ras
T6113 342-344 , denotes ,
T6114 344-349 WDT denotes which
T6115 350-352 VBZ denotes is
T6116 353-361 RB denotes upstream
T6117 362-366 IN denotes from
T6118 367-377 NN denotes activation
T6119 378-380 IN denotes of
T6120 381-385 NN denotes MAPK
T6121 386-387 -LRB- denotes [
T6122 387-388 CD denotes 9
T6123 388-389 -RRB- denotes ]
T6124 389-390 . denotes .
T6125 390-548 sentence denotes Given the increase in pMAPK staining in Tg skin, we examined the possibility that Ajuba might have changed its binding partner in Snail-expressing epidermis.
T6126 391-396 VBN denotes Given
T6128 397-400 DT denotes the
T6129 401-409 NN denotes increase
T6130 410-412 IN denotes in
T6131 413-418 NN denotes pMAPK
T6132 419-427 NN denotes staining
T6133 428-430 IN denotes in
T6134 431-433 NN denotes Tg
T6135 434-438 NN denotes skin
T6136 438-440 , denotes ,
T6137 440-442 PRP denotes we
T6127 443-451 VBD denotes examined
T6138 452-455 DT denotes the
T6139 456-467 NN denotes possibility
T6140 468-472 IN denotes that
T6142 473-478 NN denotes Ajuba
T6143 479-484 MD denotes might
T6144 485-489 VB denotes have
T6141 490-497 VBN denotes changed
T6145 498-501 PRP$ denotes its
T6147 502-509 NN denotes binding
T6146 510-517 NN denotes partner
T6148 518-520 IN denotes in
T6149 521-526 NN denotes Snail
T6151 526-527 HYPH denotes -
T6150 527-537 VBG denotes expressing
T6152 538-547 NN denotes epidermis
T6153 547-548 . denotes .
T6154 548-737 sentence denotes Interestingly, Ajuba was readily detected in anti-Grb-2 immunoprecipitates of protein lysates from skins of Snail Tg mice but not from the corresponding wild-type (WT) animals (Figure 4E).
T6155 549-562 RB denotes Interestingly
T6157 562-564 , denotes ,
T6158 564-569 NN denotes Ajuba
T6159 570-573 VBD denotes was
T6160 574-581 RB denotes readily
T6156 582-590 VBN denotes detected
T6161 591-593 IN denotes in
T6162 594-602 JJ denotes anti-Grb
T6164 602-603 HYPH denotes -
T6165 603-604 CD denotes 2
T6163 605-623 NNS denotes immunoprecipitates
T6166 624-626 IN denotes of
T6167 627-634 NN denotes protein
T6168 635-642 NNS denotes lysates
T6169 643-647 IN denotes from
T6170 648-653 NNS denotes skins
T6171 654-656 IN denotes of
T6172 657-662 NN denotes Snail
T6174 663-665 NN denotes Tg
T6173 666-670 NNS denotes mice
T6175 671-674 CC denotes but
T6176 675-678 RB denotes not
T6177 679-683 IN denotes from
T6178 684-687 DT denotes the
T6180 688-701 JJ denotes corresponding
T6181 702-706 JJ denotes wild
T6183 706-707 HYPH denotes -
T6182 707-711 NN denotes type
T6184 712-713 -LRB- denotes (
T6185 713-715 NN denotes WT
T6186 715-716 -RRB- denotes )
T6179 717-724 NNS denotes animals
T6187 725-726 -LRB- denotes (
T6189 726-732 NN denotes Figure
T6188 733-735 NN denotes 4E
T6190 735-736 -RRB- denotes )
T6191 736-737 . denotes .
T6192 737-964 sentence denotes When these experiments were repeated with α-catenin-null epidermis, a similar Grb-2-Ajuba association was detected, and again, this interaction was not detected in the protein extracts from control littermate skin (Figure 4E).
T6193 738-742 WRB denotes When
T6195 743-748 DT denotes these
T6196 749-760 NNS denotes experiments
T6197 761-765 VBD denotes were
T6194 766-774 VBN denotes repeated
T6199 775-779 IN denotes with
T6200 780-781 NN denotes α
T6202 781-782 HYPH denotes -
T6201 782-789 NN denotes catenin
T6204 789-790 HYPH denotes -
T6203 790-794 JJ denotes null
T6205 795-804 NN denotes epidermis
T6206 804-806 , denotes ,
T6207 806-807 DT denotes a
T6209 808-815 JJ denotes similar
T6210 816-819 NN denotes Grb
T6212 819-820 HYPH denotes -
T6213 820-821 CD denotes 2
T6214 821-822 HYPH denotes -
T6211 822-827 NN denotes Ajuba
T6208 828-839 NN denotes association
T6215 840-843 VBD denotes was
T6198 844-852 VBN denotes detected
T6216 852-854 , denotes ,
T6217 854-857 CC denotes and
T6218 858-863 RB denotes again
T6220 863-865 , denotes ,
T6221 865-869 DT denotes this
T6222 870-881 NN denotes interaction
T6223 882-885 VBD denotes was
T6224 886-889 RB denotes not
T6219 890-898 VBN denotes detected
T6225 899-901 IN denotes in
T6226 902-905 DT denotes the
T6228 906-913 NN denotes protein
T6227 914-922 NNS denotes extracts
T6229 923-927 IN denotes from
T6230 928-935 NN denotes control
T6232 936-946 NN denotes littermate
T6231 947-951 NN denotes skin
T6233 952-953 -LRB- denotes (
T6235 953-959 NN denotes Figure
T6234 960-962 NN denotes 4E
T6236 962-963 -RRB- denotes )
T6237 963-964 . denotes .
T6238 964-1172 sentence denotes Together, these data demonstrate that the reduction in α-catenin levels, either by Snail-mediated down-regulation of E-cadherin or by α-catenin conditional targeting, allows Ajuba to interact with Grb-2/Sos.
T6239 965-973 RB denotes Together
T6241 973-975 , denotes ,
T6242 975-980 DT denotes these
T6243 981-985 NNS denotes data
T6240 986-997 VBP denotes demonstrate
T6244 998-1002 IN denotes that
T6246 1003-1006 DT denotes the
T6247 1007-1016 NN denotes reduction
T6248 1017-1019 IN denotes in
T6249 1020-1021 NN denotes α
T6251 1021-1022 HYPH denotes -
T6250 1022-1029 NN denotes catenin
T6252 1030-1036 NNS denotes levels
T6253 1036-1038 , denotes ,
T6254 1038-1044 CC denotes either
T6255 1045-1047 IN denotes by
T6256 1048-1053 NN denotes Snail
T6258 1053-1054 HYPH denotes -
T6257 1054-1062 VBN denotes mediated
T6260 1063-1067 JJ denotes down
T6261 1067-1068 HYPH denotes -
T6259 1068-1078 NN denotes regulation
T6262 1079-1081 IN denotes of
T6263 1082-1083 NN denotes E
T6265 1083-1084 HYPH denotes -
T6264 1084-1092 NN denotes cadherin
T6266 1093-1095 CC denotes or
T6267 1096-1098 IN denotes by
T6268 1099-1100 NN denotes α
T6270 1100-1101 HYPH denotes -
T6269 1101-1108 NN denotes catenin
T6271 1109-1120 JJ denotes conditional
T6272 1121-1130 NN denotes targeting
T6273 1130-1132 , denotes ,
T6245 1132-1138 VBZ denotes allows
T6274 1139-1144 NN denotes Ajuba
T6276 1145-1147 TO denotes to
T6275 1148-1156 VB denotes interact
T6277 1157-1161 IN denotes with
T6278 1162-1165 NN denotes Grb
T6279 1165-1166 HYPH denotes -
T6280 1166-1167 CD denotes 2
T6281 1167-1168 HYPH denotes /
T6282 1168-1171 NN denotes Sos
T6283 1171-1172 . denotes .
R3651 T6041 T6042 nsubj We,turned
R3652 T6043 T6042 advmod next,turned
R3653 T6044 T6042 prep to,turned
R3654 T6045 T6046 det the,presence
R3655 T6093 T6091 nummod 2,protein
R3656 T6046 T6044 pobj presence,to
R3657 T6094 T6091 punct (,protein
R3658 T6095 T6091 appos Grb,protein
R3659 T6047 T6046 prep of,presence
R3660 T6096 T6095 punct -,Grb
R3661 T6097 T6095 nummod 2,Grb
R3662 T6048 T6049 amod cytoplasmic,Ajuba
R3663 T6098 T6091 punct ),protein
R3664 T6099 T6091 punct /,protein
R3665 T6100 T6091 appos son,protein
R3666 T6049 T6047 pobj Ajuba,of
R3667 T6101 T6100 prep of,son
R3668 T6102 T6101 pobj sevenless,of
R3669 T6103 T6100 punct (,son
R3670 T6050 T6042 prep for,turned
R3671 T6104 T6100 appos Sos,son
R3672 T6105 T6091 punct ),protein
R3673 T6106 T6091 punct ", ",protein
R3674 T6051 T6052 det a,link
R3675 T6107 T6108 det the,factor
R3676 T6108 T6091 appos factor,protein
R3677 T6109 T6108 compound nucleotide,factor
R3678 T6052 T6050 pobj link,for
R3679 T6110 T6108 compound exchange,factor
R3680 T6111 T6108 prep for,factor
R3681 T6112 T6111 pobj Ras,for
R3682 T6053 T6052 amod possible,link
R3683 T6113 T6112 punct ", ",Ras
R3684 T6114 T6115 dep which,is
R3685 T6115 T6112 relcl is,Ras
R3686 T6054 T6052 amod mechanistic,link
R3687 T6116 T6115 advmod upstream,is
R3688 T6117 T6116 prep from,upstream
R3689 T6118 T6117 pobj activation,from
R3690 T6119 T6118 prep of,activation
R3691 T6055 T6052 prep to,link
R3692 T6120 T6119 pobj MAPK,of
R3693 T6121 T6122 punct [,9
R3694 T6056 T6057 det the,increase
R3695 T6122 T6067 parataxis 9,associate
R3696 T6123 T6122 punct ],9
R3697 T6124 T6067 punct .,associate
R3698 T6057 T6055 pobj increase,to
R3699 T6126 T6127 prep Given,examined
R3700 T6058 T6057 amod proliferative,increase
R3701 T6128 T6129 det the,increase
R3702 T6129 T6126 pobj increase,Given
R3703 T6130 T6129 prep in,increase
R3704 T6131 T6132 compound pMAPK,staining
R3705 T6059 T6057 prep in,increase
R3706 T6132 T6130 pobj staining,in
R3707 T6060 T6061 poss our,epidermis
R3708 T6133 T6129 prep in,increase
R3709 T6134 T6135 compound Tg,skin
R3710 T6061 T6059 pobj epidermis,in
R3711 T6135 T6133 pobj skin,in
R3712 T6136 T6127 punct ", ",examined
R3713 T6137 T6127 nsubj we,examined
R3714 T6062 T6061 compound Snail,epidermis
R3715 T6138 T6139 det the,possibility
R3716 T6139 T6127 dobj possibility,examined
R3717 T6140 T6141 mark that,changed
R3718 T6063 T6061 compound Tg,epidermis
R3719 T6141 T6139 acl changed,possibility
R3720 T6142 T6141 nsubj Ajuba,changed
R3721 T6143 T6141 aux might,changed
R3722 T6064 T6042 punct .,turned
R3723 T6144 T6141 aux have,changed
R3724 T6145 T6146 poss its,partner
R3725 T6146 T6141 dobj partner,changed
R3726 T6066 T6067 prep In,associate
R3727 T6147 T6146 compound binding,partner
R3728 T6148 T6141 prep in,changed
R3729 T6149 T6150 npadvmod Snail,expressing
R3730 T6150 T6152 amod expressing,epidermis
R3731 T6151 T6150 punct -,expressing
R3732 T6068 T6066 pobj addition,In
R3733 T6152 T6148 pobj epidermis,in
R3734 T6153 T6127 punct .,examined
R3735 T6155 T6156 advmod Interestingly,detected
R3736 T6069 T6068 prep to,addition
R3737 T6157 T6156 punct ", ",detected
R3738 T6070 T6071 poss its,ability
R3739 T6158 T6156 nsubjpass Ajuba,detected
R3740 T6159 T6156 auxpass was,detected
R3741 T6160 T6156 advmod readily,detected
R3742 T6071 T6069 pobj ability,to
R3743 T6161 T6156 prep in,detected
R3744 T6162 T6163 amod anti-Grb,immunoprecipitates
R3745 T6163 T6161 pobj immunoprecipitates,in
R3746 T6072 T6071 amod documented,ability
R3747 T6164 T6162 punct -,anti-Grb
R3748 T6165 T6162 advmod 2,anti-Grb
R3749 T6073 T6074 aux to,bind
R3750 T6166 T6163 prep of,immunoprecipitates
R3751 T6167 T6168 compound protein,lysates
R3752 T6168 T6166 pobj lysates,of
R3753 T6074 T6071 acl bind,ability
R3754 T6169 T6168 prep from,lysates
R3755 T6170 T6169 pobj skins,from
R3756 T6171 T6170 prep of,skins
R3757 T6075 T6076 compound α,catenin
R3758 T6172 T6173 compound Snail,mice
R3759 T6173 T6171 pobj mice,of
R3760 T6076 T6074 dobj catenin,bind
R3761 T6174 T6173 compound Tg,mice
R3762 T6175 T6169 cc but,from
R3763 T6176 T6175 neg not,but
R3764 T6077 T6076 punct -,catenin
R3765 T6177 T6169 conj from,from
R3766 T6178 T6179 det the,animals
R3767 T6078 T6079 punct [,10
R3768 T6179 T6177 pobj animals,from
R3769 T6180 T6179 amod corresponding,animals
R3770 T6181 T6182 amod wild,type
R3771 T6079 T6068 parataxis 10,addition
R3772 T6182 T6179 nmod type,animals
R3773 T6183 T6182 punct -,type
R3774 T6184 T6182 punct (,type
R3775 T6080 T6079 punct ],10
R3776 T6185 T6182 appos WT,type
R3777 T6186 T6179 punct ),animals
R3778 T6081 T6067 punct ", ",associate
R3779 T6187 T6188 punct (,4E
R3780 T6188 T6156 parataxis 4E,detected
R3781 T6189 T6188 compound Figure,4E
R3782 T6082 T6067 nsubj Ajuba,associate
R3783 T6190 T6188 punct ),4E
R3784 T6191 T6156 punct .,detected
R3785 T6083 T6067 aux can,associate
R3786 T6193 T6194 advmod When,repeated
R3787 T6194 T6198 advcl repeated,detected
R3788 T6195 T6196 det these,experiments
R3789 T6084 T6067 advmod also,associate
R3790 T6196 T6194 nsubjpass experiments,repeated
R3791 T6197 T6194 auxpass were,repeated
R3792 T6085 T6067 prep with,associate
R3793 T6086 T6087 compound growth,factor
R3794 T6087 T6088 compound factor,receptor
R3795 T6199 T6194 prep with,repeated
R3796 T6088 T6089 npadvmod receptor,bound
R3797 T6200 T6201 compound α,catenin
R3798 T6201 T6203 npadvmod catenin,null
R3799 T6202 T6201 punct -,catenin
R3800 T6089 T6091 amod bound,protein
R3801 T6203 T6205 amod null,epidermis
R3802 T6204 T6203 punct -,null
R3803 T6205 T6199 pobj epidermis,with
R3804 T6090 T6089 punct -,bound
R3805 T6206 T6198 punct ", ",detected
R3806 T6207 T6208 det a,association
R3807 T6208 T6198 nsubjpass association,detected
R3808 T6209 T6208 amod similar,association
R3809 T6210 T6211 nmod Grb,Ajuba
R3810 T6211 T6208 compound Ajuba,association
R3811 T6091 T6085 pobj protein,with
R3812 T6212 T6211 punct -,Ajuba
R3813 T6213 T6211 nummod 2,Ajuba
R3814 T6214 T6211 punct -,Ajuba
R3815 T6215 T6198 auxpass was,detected
R3816 T6092 T6091 punct -,protein
R3817 T6216 T6198 punct ", ",detected
R3818 T6217 T6198 cc and,detected
R3819 T6218 T6219 advmod again,detected
R3821 T6219 T6198 conj detected,detected
R3822 T6220 T6219 punct ", ",detected
R3823 T6221 T6222 det this,interaction
R3824 T6222 T6219 nsubjpass interaction,detected
R3825 T6223 T6219 auxpass was,detected
R3827 T6224 T6219 neg not,detected
R3828 T6225 T6219 prep in,detected
R3829 T6226 T6227 det the,extracts
R3830 T6227 T6225 pobj extracts,in
R3832 T6228 T6227 compound protein,extracts
R3833 T6229 T6227 prep from,extracts
R3834 T6230 T6231 compound control,skin
R3836 T6231 T6229 pobj skin,from
R3837 T6232 T6231 compound littermate,skin
R3838 T6233 T6234 punct (,4E
R3840 T6234 T6219 parataxis 4E,detected
R3841 T6235 T6234 compound Figure,4E
R3842 T6236 T6234 punct ),4E
R3844 T6237 T6198 punct .,detected
R3845 T6239 T6240 advmod Together,demonstrate
R3847 T6241 T6240 punct ", ",demonstrate
R3848 T6242 T6243 det these,data
R3849 T6243 T6240 nsubj data,demonstrate
R3851 T6244 T6245 mark that,allows
R3853 T6245 T6240 ccomp allows,demonstrate
R3854 T6246 T6247 det the,reduction
R3856 T6247 T6245 nsubj reduction,allows
R3857 T6248 T6247 prep in,reduction
R3858 T6249 T6250 compound α,catenin
R3859 T6250 T6252 compound catenin,levels
R3860 T6251 T6250 punct -,catenin
R3861 T6252 T6248 pobj levels,in
R3862 T6253 T6247 punct ", ",reduction
R3864 T6254 T6255 preconj either,by
R3865 T6255 T6247 prep by,reduction
R3866 T6256 T6257 npadvmod Snail,mediated
R3868 T6257 T6259 amod mediated,regulation
R3869 T6258 T6257 punct -,mediated
R3870 T6259 T6255 pobj regulation,by
R3872 T6260 T6259 amod down,regulation
R3873 T6261 T6259 punct -,regulation
R3874 T6262 T6259 prep of,regulation
R3876 T6263 T6264 compound E,cadherin
R3877 T6264 T6262 pobj cadherin,of
R3878 T6265 T6264 punct -,cadherin
R3880 T6266 T6255 cc or,by
R3881 T6267 T6255 conj by,by
R3882 T6268 T6269 compound α,catenin
R3884 T6269 T6271 npadvmod catenin,conditional
R3885 T6270 T6269 punct -,catenin
R3886 T6271 T6272 amod conditional,targeting
R3888 T6272 T6267 pobj targeting,by
R3889 T6273 T6245 punct ", ",allows
R3890 T6274 T6275 nsubj Ajuba,interact
R3892 T6275 T6245 ccomp interact,allows
R3893 T6276 T6275 aux to,interact
R3894 T6277 T6275 prep with,interact
R3896 T6278 T6277 pobj Grb,with
R3897 T6279 T6278 punct -,Grb
R3898 T6280 T6278 nummod 2,Grb
R3899 T6281 T6278 punct /,Grb
R3901 T6282 T6278 appos Sos,Grb
R3902 T6283 T6240 punct .,demonstrate