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PMC:539061 / 21907-22933 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T4363 0-3 DT denotes The
T4364 4-11 NNS denotes changes
T4366 12-14 IN denotes in
T4367 15-33 NN denotes hyperproliferation
T4368 34-37 CC denotes and
T4369 38-53 NN denotes differentiation
T4370 54-58 VBD denotes were
T4371 59-62 RB denotes not
T4372 63-72 RB denotes initially
T4365 73-84 VBN denotes accompanied
T4373 85-87 IN denotes by
T4374 88-93 JJ denotes gross
T4375 94-99 NNS denotes signs
T4376 100-102 IN denotes of
T4377 103-113 JJ denotes epithelial
T4378 114-127 NNS denotes invaginations
T4379 127-128 . denotes .
T4380 128-322 sentence denotes With age, however, epidermal folds and undulations developed in areas where Snail was expressed, and proliferative markers persisted in these regions (Figure 3I and 3J; anti-cyclin D staining).
T4381 129-133 IN denotes With
T4383 134-137 NN denotes age
T4384 137-139 , denotes ,
T4385 139-146 RB denotes however
T4386 146-148 , denotes ,
T4387 148-157 JJ denotes epidermal
T4388 158-163 NNS denotes folds
T4389 164-167 CC denotes and
T4390 168-179 NNS denotes undulations
T4382 180-189 VBN denotes developed
T4391 190-192 IN denotes in
T4392 193-198 NNS denotes areas
T4393 199-204 WRB denotes where
T4395 205-210 NN denotes Snail
T4396 211-214 VBD denotes was
T4394 215-224 VBN denotes expressed
T4397 224-226 , denotes ,
T4398 226-229 CC denotes and
T4399 230-243 JJ denotes proliferative
T4400 244-251 NNS denotes markers
T4401 252-261 VBD denotes persisted
T4402 262-264 IN denotes in
T4403 265-270 DT denotes these
T4404 271-278 NNS denotes regions
T4405 279-280 -LRB- denotes (
T4407 280-286 NN denotes Figure
T4408 287-289 NN denotes 3I
T4409 290-293 CC denotes and
T4410 294-296 NN denotes 3J
T4411 296-297 : denotes ;
T4412 298-309 JJ denotes anti-cyclin
T4413 310-311 NN denotes D
T4406 312-320 NN denotes staining
T4414 320-321 -RRB- denotes )
T4415 321-322 . denotes .
T4416 322-434 sentence denotes The undulations were accompanied by partial dissolution of the underlying basement membrane (Figure 3K and 3L).
T4417 323-326 DT denotes The
T4418 327-338 NNS denotes undulations
T4420 339-343 VBD denotes were
T4419 344-355 VBN denotes accompanied
T4421 356-358 IN denotes by
T4422 359-366 JJ denotes partial
T4423 367-378 NN denotes dissolution
T4424 379-381 IN denotes of
T4425 382-385 DT denotes the
T4427 386-396 JJ denotes underlying
T4428 397-405 NN denotes basement
T4426 406-414 NN denotes membrane
T4429 415-416 -LRB- denotes (
T4431 416-422 NN denotes Figure
T4430 423-425 NN denotes 3K
T4432 426-429 CC denotes and
T4433 430-432 NN denotes 3L
T4434 432-433 -RRB- denotes )
T4435 433-434 . denotes .
T4436 434-634 sentence denotes Aberrant staining was also observed with antibodies against components of the hemidesmosomes, which provide strong adhesion of basal epidermal cells to the underlying basal lamina (Figure 3M and 3N).
T4437 435-443 JJ denotes Aberrant
T4438 444-452 NN denotes staining
T4440 453-456 VBD denotes was
T4441 457-461 RB denotes also
T4439 462-470 VBN denotes observed
T4442 471-475 IN denotes with
T4443 476-486 NNS denotes antibodies
T4444 487-494 IN denotes against
T4445 495-505 NNS denotes components
T4446 506-508 IN denotes of
T4447 509-512 DT denotes the
T4448 513-527 NNS denotes hemidesmosomes
T4449 527-529 , denotes ,
T4450 529-534 WDT denotes which
T4451 535-542 VBP denotes provide
T4452 543-549 JJ denotes strong
T4453 550-558 NN denotes adhesion
T4454 559-561 IN denotes of
T4455 562-567 JJ denotes basal
T4457 568-577 JJ denotes epidermal
T4456 578-583 NNS denotes cells
T4458 584-586 IN denotes to
T4459 587-590 DT denotes the
T4461 591-601 JJ denotes underlying
T4462 602-607 JJ denotes basal
T4460 608-614 NN denotes lamina
T4463 615-616 -LRB- denotes (
T4465 616-622 NN denotes Figure
T4464 623-625 NN denotes 3M
T4466 626-629 CC denotes and
T4467 630-632 NN denotes 3N
T4468 632-633 -RRB- denotes )
T4469 633-634 . denotes .
T4470 634-789 sentence denotes Interestingly, similar types of alterations occur in the basement membrane in the hair bud of embryonic and newborn mice when Snail is normally expressed.
T4471 635-648 RB denotes Interestingly
T4473 648-650 , denotes ,
T4474 650-657 JJ denotes similar
T4475 658-663 NNS denotes types
T4476 664-666 IN denotes of
T4477 667-678 NNS denotes alterations
T4472 679-684 VBP denotes occur
T4478 685-687 IN denotes in
T4479 688-691 DT denotes the
T4481 692-700 NN denotes basement
T4480 701-709 NN denotes membrane
T4482 710-712 IN denotes in
T4483 713-716 DT denotes the
T4485 717-721 NN denotes hair
T4484 722-725 NN denotes bud
T4486 726-728 IN denotes of
T4487 729-738 JJ denotes embryonic
T4489 739-742 CC denotes and
T4490 743-750 JJ denotes newborn
T4488 751-755 NNS denotes mice
T4491 756-760 WRB denotes when
T4493 761-766 NN denotes Snail
T4494 767-769 VBZ denotes is
T4495 770-778 RB denotes normally
T4492 779-788 VBN denotes expressed
T4496 788-789 . denotes .
T4497 789-1026 sentence denotes The fact that the basement membrane separating the epidermis from the dermis is altered only in the adult Tg animals suggests the involvement of intermediary factors not as readily available in the epidermis as they are in the follicle.
T4498 790-793 DT denotes The
T4499 794-798 NN denotes fact
T4501 799-803 IN denotes that
T4503 804-807 DT denotes the
T4505 808-816 NN denotes basement
T4504 817-825 NN denotes membrane
T4506 826-836 VBG denotes separating
T4507 837-840 DT denotes the
T4508 841-850 NN denotes epidermis
T4509 851-855 IN denotes from
T4510 856-859 DT denotes the
T4511 860-866 NN denotes dermis
T4512 867-869 VBZ denotes is
T4502 870-877 VBN denotes altered
T4513 878-882 RB denotes only
T4514 883-885 IN denotes in
T4515 886-889 DT denotes the
T4517 890-895 JJ denotes adult
T4518 896-898 NN denotes Tg
T4516 899-906 NNS denotes animals
T4500 907-915 VBZ denotes suggests
T4519 916-919 DT denotes the
T4520 920-931 NN denotes involvement
T4521 932-934 IN denotes of
T4522 935-947 JJ denotes intermediary
T4523 948-955 NNS denotes factors
T4524 956-959 RB denotes not
T4526 960-962 RB denotes as
T4527 963-970 RB denotes readily
T4525 971-980 JJ denotes available
T4528 981-983 IN denotes in
T4529 984-987 DT denotes the
T4530 988-997 NN denotes epidermis
T4531 998-1000 IN denotes as
T4533 1001-1005 PRP denotes they
T4532 1006-1009 VBP denotes are
T4534 1010-1012 IN denotes in
T4535 1013-1016 DT denotes the
T4536 1017-1025 NN denotes follicle
T4537 1025-1026 . denotes .
R2710 T4363 T4364 det The,changes
R2711 T4364 T4365 nsubjpass changes,accompanied
R2712 T4366 T4364 prep in,changes
R2713 T4367 T4366 pobj hyperproliferation,in
R2714 T4368 T4367 cc and,hyperproliferation
R2715 T4369 T4367 conj differentiation,hyperproliferation
R2716 T4370 T4365 auxpass were,accompanied
R2717 T4371 T4365 neg not,accompanied
R2718 T4372 T4365 advmod initially,accompanied
R2719 T4373 T4365 agent by,accompanied
R2720 T4374 T4375 amod gross,signs
R2721 T4375 T4373 pobj signs,by
R2722 T4376 T4375 prep of,signs
R2723 T4377 T4378 amod epithelial,invaginations
R2724 T4378 T4376 pobj invaginations,of
R2725 T4379 T4365 punct .,accompanied
R2726 T4381 T4382 prep With,developed
R2727 T4383 T4381 pobj age,With
R2728 T4384 T4382 punct ", ",developed
R2729 T4385 T4382 advmod however,developed
R2730 T4386 T4382 punct ", ",developed
R2731 T4387 T4388 amod epidermal,folds
R2732 T4388 T4382 nsubj folds,developed
R2733 T4389 T4388 cc and,folds
R2734 T4390 T4388 conj undulations,folds
R2735 T4391 T4382 prep in,developed
R2736 T4392 T4391 pobj areas,in
R2737 T4393 T4394 advmod where,expressed
R2738 T4394 T4392 relcl expressed,areas
R2739 T4395 T4394 nsubjpass Snail,expressed
R2740 T4396 T4394 auxpass was,expressed
R2741 T4397 T4382 punct ", ",developed
R2742 T4398 T4382 cc and,developed
R2743 T4399 T4400 amod proliferative,markers
R2744 T4400 T4401 nsubj markers,persisted
R2745 T4401 T4382 conj persisted,developed
R2746 T4402 T4401 prep in,persisted
R2747 T4403 T4404 det these,regions
R2748 T4404 T4402 pobj regions,in
R2749 T4405 T4406 punct (,staining
R2750 T4406 T4401 parataxis staining,persisted
R2751 T4407 T4408 compound Figure,3I
R2752 T4408 T4406 dep 3I,staining
R2753 T4409 T4408 cc and,3I
R2754 T4410 T4408 conj 3J,3I
R2755 T4411 T4406 punct ;,staining
R2756 T4412 T4413 amod anti-cyclin,D
R2757 T4413 T4406 compound D,staining
R2758 T4414 T4406 punct ),staining
R2759 T4415 T4382 punct .,developed
R2760 T4417 T4418 det The,undulations
R2761 T4418 T4419 nsubjpass undulations,accompanied
R2762 T4420 T4419 auxpass were,accompanied
R2763 T4421 T4419 agent by,accompanied
R2764 T4422 T4423 amod partial,dissolution
R2765 T4423 T4421 pobj dissolution,by
R2766 T4424 T4423 prep of,dissolution
R2767 T4425 T4426 det the,membrane
R2768 T4426 T4424 pobj membrane,of
R2769 T4427 T4426 amod underlying,membrane
R2770 T4428 T4426 compound basement,membrane
R2771 T4429 T4430 punct (,3K
R2772 T4430 T4419 parataxis 3K,accompanied
R2773 T4431 T4430 compound Figure,3K
R2774 T4432 T4430 cc and,3K
R2775 T4433 T4430 conj 3L,3K
R2776 T4434 T4430 punct ),3K
R2777 T4435 T4419 punct .,accompanied
R2778 T4437 T4438 amod Aberrant,staining
R2779 T4438 T4439 nsubjpass staining,observed
R2780 T4440 T4439 auxpass was,observed
R2781 T4441 T4439 advmod also,observed
R2782 T4442 T4439 prep with,observed
R2783 T4443 T4442 pobj antibodies,with
R2784 T4444 T4443 prep against,antibodies
R2785 T4445 T4444 pobj components,against
R2786 T4446 T4445 prep of,components
R2787 T4447 T4448 det the,hemidesmosomes
R2788 T4448 T4446 pobj hemidesmosomes,of
R2789 T4449 T4445 punct ", ",components
R2790 T4450 T4451 dep which,provide
R2791 T4451 T4445 relcl provide,components
R2792 T4452 T4453 amod strong,adhesion
R2793 T4453 T4451 dobj adhesion,provide
R2794 T4454 T4453 prep of,adhesion
R2795 T4455 T4456 amod basal,cells
R2796 T4456 T4454 pobj cells,of
R2797 T4457 T4456 amod epidermal,cells
R2798 T4458 T4451 prep to,provide
R2799 T4459 T4460 det the,lamina
R2800 T4460 T4458 pobj lamina,to
R2801 T4461 T4460 amod underlying,lamina
R2802 T4462 T4460 amod basal,lamina
R2803 T4463 T4464 punct (,3M
R2804 T4464 T4439 parataxis 3M,observed
R2805 T4465 T4464 compound Figure,3M
R2806 T4466 T4464 cc and,3M
R2807 T4467 T4464 conj 3N,3M
R2808 T4468 T4464 punct ),3M
R2809 T4469 T4439 punct .,observed
R2810 T4471 T4472 advmod Interestingly,occur
R2811 T4473 T4472 punct ", ",occur
R2812 T4474 T4475 amod similar,types
R2813 T4475 T4472 nsubj types,occur
R2814 T4476 T4475 prep of,types
R2815 T4477 T4476 pobj alterations,of
R2816 T4478 T4472 prep in,occur
R2817 T4479 T4480 det the,membrane
R2818 T4480 T4478 pobj membrane,in
R2819 T4481 T4480 compound basement,membrane
R2820 T4482 T4472 prep in,occur
R2821 T4483 T4484 det the,bud
R2822 T4484 T4482 pobj bud,in
R2823 T4485 T4484 compound hair,bud
R2824 T4486 T4484 prep of,bud
R2825 T4487 T4488 amod embryonic,mice
R2826 T4488 T4486 pobj mice,of
R2827 T4489 T4487 cc and,embryonic
R2828 T4490 T4487 conj newborn,embryonic
R2829 T4491 T4492 advmod when,expressed
R2830 T4492 T4472 advcl expressed,occur
R2831 T4493 T4492 nsubjpass Snail,expressed
R2832 T4494 T4492 auxpass is,expressed
R2833 T4495 T4492 advmod normally,expressed
R2834 T4496 T4472 punct .,occur
R2835 T4498 T4499 det The,fact
R2836 T4499 T4500 nsubj fact,suggests
R2837 T4501 T4502 mark that,altered
R2838 T4502 T4499 acl altered,fact
R2839 T4503 T4504 det the,membrane
R2840 T4504 T4502 nsubjpass membrane,altered
R2841 T4505 T4504 compound basement,membrane
R2842 T4506 T4504 acl separating,membrane
R2843 T4507 T4508 det the,epidermis
R2844 T4508 T4506 dobj epidermis,separating
R2845 T4509 T4506 prep from,separating
R2846 T4510 T4511 det the,dermis
R2847 T4511 T4509 pobj dermis,from
R2848 T4512 T4502 auxpass is,altered
R2849 T4513 T4514 advmod only,in
R2850 T4514 T4502 prep in,altered
R2851 T4515 T4516 det the,animals
R2852 T4516 T4514 pobj animals,in
R2853 T4517 T4516 amod adult,animals
R2854 T4518 T4516 compound Tg,animals
R2855 T4519 T4520 det the,involvement
R2856 T4520 T4500 dobj involvement,suggests
R2857 T4521 T4520 prep of,involvement
R2858 T4522 T4523 amod intermediary,factors
R2859 T4523 T4521 pobj factors,of
R2860 T4524 T4525 neg not,available
R2861 T4525 T4523 relcl available,factors
R2862 T4526 T4527 advmod as,readily
R2863 T4527 T4525 advmod readily,available
R2864 T4528 T4525 prep in,available
R2865 T4529 T4530 det the,epidermis
R2866 T4530 T4528 pobj epidermis,in
R2867 T4531 T4532 mark as,are
R2868 T4532 T4525 advcl are,available
R2869 T4533 T4532 nsubj they,are
R2870 T4534 T4532 prep in,are
R2871 T4535 T4536 det the,follicle
R2872 T4536 T4534 pobj follicle,in
R2873 T4537 T4500 punct .,suggests