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PMC:539061 / 1627-8397 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1019 13-22 JJ denotes Mammalian
T1020 23-34 NN denotes development
T1021 35-43 VBZ denotes involves
T1022 44-47 DT denotes the
T1023 48-61 NN denotes morphogenesis
T1024 62-64 IN denotes of
T1025 65-72 JJ denotes complex
T1027 73-78 CD denotes three
T1029 78-79 HYPH denotes -
T1028 79-90 JJ denotes dimensional
T1026 91-101 NNS denotes structures
T1030 102-106 IN denotes from
T1031 107-116 RB denotes seemingly
T1032 117-124 JJ denotes uniform
T1033 125-131 NNS denotes sheets
T1034 132-134 CC denotes or
T1035 135-141 NNS denotes masses
T1036 142-144 IN denotes of
T1037 145-150 NNS denotes cells
T1038 150-151 . denotes .
T1039 151-289 sentence denotes A simple bud-like structure initiates the formation of many organs, including lungs, spinal cord, mammary glands, and hair follicles [1].
T1040 152-153 DT denotes A
T1042 154-160 JJ denotes simple
T1043 161-164 NN denotes bud
T1045 164-165 HYPH denotes -
T1044 165-169 JJ denotes like
T1041 170-179 NN denotes structure
T1046 180-189 VBZ denotes initiates
T1047 190-193 DT denotes the
T1048 194-203 NN denotes formation
T1049 204-206 IN denotes of
T1050 207-211 JJ denotes many
T1051 212-218 NNS denotes organs
T1052 218-220 , denotes ,
T1053 220-229 VBG denotes including
T1054 230-235 NNS denotes lungs
T1055 235-237 , denotes ,
T1056 237-243 JJ denotes spinal
T1057 244-248 NN denotes cord
T1058 248-250 , denotes ,
T1059 250-257 JJ denotes mammary
T1060 258-264 NNS denotes glands
T1061 264-266 , denotes ,
T1062 266-269 CC denotes and
T1063 270-274 NN denotes hair
T1064 275-284 NNS denotes follicles
T1065 285-286 -LRB- denotes [
T1066 286-287 CD denotes 1
T1067 287-288 -RRB- denotes ]
T1068 288-289 . denotes .
T1069 289-467 sentence denotes The multipotent, adhering epithelial cells are typically attached to an underlying basal lamina that polarizes the epithelial sheet and separates it from surrounding mesenchyme.
T1070 290-293 DT denotes The
T1072 294-305 JJ denotes multipotent
T1073 305-307 , denotes ,
T1074 307-315 VBG denotes adhering
T1075 316-326 JJ denotes epithelial
T1071 327-332 NNS denotes cells
T1077 333-336 VBP denotes are
T1078 337-346 RB denotes typically
T1076 347-355 VBN denotes attached
T1079 356-358 IN denotes to
T1080 359-361 DT denotes an
T1082 362-372 VBG denotes underlying
T1083 373-378 JJ denotes basal
T1081 379-385 NN denotes lamina
T1084 386-390 WDT denotes that
T1085 391-400 VBZ denotes polarizes
T1086 401-404 DT denotes the
T1088 405-415 JJ denotes epithelial
T1087 416-421 NN denotes sheet
T1089 422-425 CC denotes and
T1090 426-435 VBZ denotes separates
T1091 436-438 PRP denotes it
T1092 439-443 IN denotes from
T1093 444-455 VBG denotes surrounding
T1094 456-466 NN denotes mesenchyme
T1095 466-467 . denotes .
T1096 467-647 sentence denotes Budding morphogenesis is guided by a reciprocal exchange of signals between epithelium and mesenchyme to specify the identity of the organ that will form and to govern its growth.
T1097 468-475 VBG denotes Budding
T1098 476-489 NN denotes morphogenesis
T1100 490-492 VBZ denotes is
T1099 493-499 VBN denotes guided
T1101 500-502 IN denotes by
T1102 503-504 DT denotes a
T1104 505-515 JJ denotes reciprocal
T1103 516-524 NN denotes exchange
T1105 525-527 IN denotes of
T1106 528-535 NNS denotes signals
T1107 536-543 IN denotes between
T1108 544-554 NN denotes epithelium
T1109 555-558 CC denotes and
T1110 559-569 NN denotes mesenchyme
T1111 570-572 TO denotes to
T1112 573-580 VB denotes specify
T1113 581-584 DT denotes the
T1114 585-593 NN denotes identity
T1115 594-596 IN denotes of
T1116 597-600 DT denotes the
T1117 601-606 NN denotes organ
T1118 607-611 WDT denotes that
T1120 612-616 MD denotes will
T1119 617-621 VB denotes form
T1121 622-625 CC denotes and
T1122 626-628 TO denotes to
T1123 629-635 VB denotes govern
T1124 636-639 PRP$ denotes its
T1125 640-646 NN denotes growth
T1126 646-647 . denotes .
T1127 647-823 sentence denotes At the helm of these molecular communication pathways are Wnts, bone morphogenic proteins (BMPs), transforming growth factor βs (TGF-βs), and fibroblast growth factors (FGFs).
T1128 648-650 IN denotes At
T1130 651-654 DT denotes the
T1131 655-659 NN denotes helm
T1132 660-662 IN denotes of
T1133 663-668 DT denotes these
T1135 669-678 JJ denotes molecular
T1136 679-692 NN denotes communication
T1134 693-701 NNS denotes pathways
T1129 702-705 VBP denotes are
T1137 706-710 NNS denotes Wnts
T1138 710-712 , denotes ,
T1139 712-716 NN denotes bone
T1141 717-728 JJ denotes morphogenic
T1140 729-737 NN denotes proteins
T1142 738-739 -LRB- denotes (
T1143 739-743 NNS denotes BMPs
T1144 743-744 -RRB- denotes )
T1145 744-746 , denotes ,
T1146 746-758 VBG denotes transforming
T1148 759-765 NN denotes growth
T1149 766-772 NN denotes factor
T1147 773-775 NNS denotes βs
T1150 776-777 -LRB- denotes (
T1151 777-780 NN denotes TGF
T1153 780-781 HYPH denotes -
T1152 781-783 NNS denotes βs
T1154 783-784 -RRB- denotes )
T1155 784-786 , denotes ,
T1156 786-789 CC denotes and
T1157 790-800 NN denotes fibroblast
T1159 801-807 NN denotes growth
T1158 808-815 NNS denotes factors
T1160 816-817 -LRB- denotes (
T1161 817-821 NNS denotes FGFs
T1162 821-822 -RRB- denotes )
T1163 822-823 . denotes .
T1164 823-1047 sentence denotes Through activation of cell surface transmembrane receptors, these external signaling molecules trigger distinct cascades of intracellular events that culminate in changes in gene expression, growth, and differentiation [2].
T1165 824-831 IN denotes Through
T1167 832-842 NN denotes activation
T1168 843-845 IN denotes of
T1169 846-850 NN denotes cell
T1170 851-858 NN denotes surface
T1172 859-872 NN denotes transmembrane
T1171 873-882 NNS denotes receptors
T1173 882-884 , denotes ,
T1174 884-889 DT denotes these
T1176 890-898 JJ denotes external
T1177 899-908 NN denotes signaling
T1175 909-918 NNS denotes molecules
T1166 919-926 VBP denotes trigger
T1178 927-935 JJ denotes distinct
T1179 936-944 NNS denotes cascades
T1180 945-947 IN denotes of
T1181 948-961 JJ denotes intracellular
T1182 962-968 NNS denotes events
T1183 969-973 WDT denotes that
T1184 974-983 VBP denotes culminate
T1185 984-986 IN denotes in
T1186 987-994 NNS denotes changes
T1187 995-997 IN denotes in
T1188 998-1002 NN denotes gene
T1189 1003-1013 NN denotes expression
T1190 1013-1015 , denotes ,
T1191 1015-1021 NN denotes growth
T1192 1021-1023 , denotes ,
T1193 1023-1026 CC denotes and
T1194 1027-1042 NN denotes differentiation
T1195 1043-1044 -LRB- denotes [
T1196 1044-1045 CD denotes 2
T1197 1045-1046 -RRB- denotes ]
T1198 1046-1047 . denotes .
T1199 1047-1220 sentence denotes How this constellation of signals collaborates in tailoring each budding process so that it executes a distinct morphogenetic program has yet to be comprehensively defined.
T1200 1048-1051 WRB denotes How
T1202 1052-1056 DT denotes this
T1203 1057-1070 NN denotes constellation
T1204 1071-1073 IN denotes of
T1205 1074-1081 NNS denotes signals
T1201 1082-1094 VBZ denotes collaborates
T1207 1095-1097 IN denotes in
T1208 1098-1107 VBG denotes tailoring
T1209 1108-1112 DT denotes each
T1211 1113-1120 NN denotes budding
T1210 1121-1128 NN denotes process
T1212 1129-1131 IN denotes so
T1214 1132-1136 IN denotes that
T1215 1137-1139 PRP denotes it
T1213 1140-1148 VBZ denotes executes
T1216 1149-1150 DT denotes a
T1218 1151-1159 JJ denotes distinct
T1219 1160-1173 JJ denotes morphogenetic
T1217 1174-1181 NN denotes program
T1206 1182-1185 VBZ denotes has
T1220 1186-1189 RB denotes yet
T1222 1190-1192 TO denotes to
T1223 1193-1195 VB denotes be
T1224 1196-1211 RB denotes comprehensively
T1221 1212-1219 VBN denotes defined
T1225 1219-1220 . denotes .
T1226 1220-1446 sentence denotes However, the process appears to be patterned at the initial stages of bud formation, since the relative importance of these pathways and their downstream effectors differ as buds begin to develop and cell fates are specified.
T1227 1221-1228 RB denotes However
T1229 1228-1230 , denotes ,
T1230 1230-1233 DT denotes the
T1231 1234-1241 NN denotes process
T1228 1242-1249 VBZ denotes appears
T1232 1250-1252 TO denotes to
T1234 1253-1255 VB denotes be
T1233 1256-1265 VBN denotes patterned
T1235 1266-1268 IN denotes at
T1236 1269-1272 DT denotes the
T1238 1273-1280 JJ denotes initial
T1237 1281-1287 NNS denotes stages
T1239 1288-1290 IN denotes of
T1240 1291-1294 NN denotes bud
T1241 1295-1304 NN denotes formation
T1242 1304-1306 , denotes ,
T1243 1306-1311 IN denotes since
T1245 1312-1315 DT denotes the
T1247 1316-1324 JJ denotes relative
T1246 1325-1335 NN denotes importance
T1248 1336-1338 IN denotes of
T1249 1339-1344 DT denotes these
T1250 1345-1353 NNS denotes pathways
T1251 1354-1357 CC denotes and
T1252 1358-1363 PRP$ denotes their
T1254 1364-1374 JJ denotes downstream
T1253 1375-1384 NNS denotes effectors
T1244 1385-1391 VBP denotes differ
T1255 1392-1394 IN denotes as
T1257 1395-1399 NNS denotes buds
T1256 1400-1405 VBP denotes begin
T1258 1406-1408 TO denotes to
T1259 1409-1416 VB denotes develop
T1260 1417-1420 CC denotes and
T1261 1421-1425 NN denotes cell
T1262 1426-1431 NNS denotes fates
T1264 1432-1435 VBP denotes are
T1263 1436-1445 VBN denotes specified
T1265 1445-1446 . denotes .
T1266 1446-1578 sentence denotes The development of a bud requires a number of coordinated changes in the behavior of the targeted cells within an epithelial sheet.
T1267 1447-1450 DT denotes The
T1268 1451-1462 NN denotes development
T1270 1463-1465 IN denotes of
T1271 1466-1467 DT denotes a
T1272 1468-1471 NN denotes bud
T1269 1472-1480 VBZ denotes requires
T1273 1481-1482 DT denotes a
T1274 1483-1489 NN denotes number
T1275 1490-1492 IN denotes of
T1276 1493-1504 VBN denotes coordinated
T1277 1505-1512 NNS denotes changes
T1278 1513-1515 IN denotes in
T1279 1516-1519 DT denotes the
T1280 1520-1528 NN denotes behavior
T1281 1529-1531 IN denotes of
T1282 1532-1535 DT denotes the
T1284 1536-1544 VBN denotes targeted
T1283 1545-1550 NNS denotes cells
T1285 1551-1557 IN denotes within
T1286 1558-1560 DT denotes an
T1288 1561-1571 JJ denotes epithelial
T1287 1572-1577 NN denotes sheet
T1289 1577-1578 . denotes .
T1290 1578-1762 sentence denotes The process must be accompanied by alterations in the proliferation, polarity, shape, and adhesiveness of selected cells, as well as by modifications in their underlying basal lamina.
T1291 1579-1582 DT denotes The
T1292 1583-1590 NN denotes process
T1294 1591-1595 MD denotes must
T1295 1596-1598 VB denotes be
T1293 1599-1610 VBN denotes accompanied
T1296 1611-1613 IN denotes by
T1297 1614-1625 NNS denotes alterations
T1298 1626-1628 IN denotes in
T1299 1629-1632 DT denotes the
T1300 1633-1646 NN denotes proliferation
T1301 1646-1648 , denotes ,
T1302 1648-1656 NN denotes polarity
T1303 1656-1658 , denotes ,
T1304 1658-1663 NN denotes shape
T1305 1663-1665 , denotes ,
T1306 1665-1668 CC denotes and
T1307 1669-1681 NN denotes adhesiveness
T1308 1682-1684 IN denotes of
T1309 1685-1693 VBN denotes selected
T1310 1694-1699 NNS denotes cells
T1311 1699-1701 , denotes ,
T1312 1701-1703 RB denotes as
T1314 1704-1708 RB denotes well
T1313 1709-1711 IN denotes as
T1315 1712-1714 IN denotes by
T1316 1715-1728 NNS denotes modifications
T1317 1729-1731 IN denotes in
T1318 1732-1737 PRP$ denotes their
T1320 1738-1748 VBG denotes underlying
T1321 1749-1754 JJ denotes basal
T1319 1755-1761 NN denotes lamina
T1322 1761-1762 . denotes .
T1323 1762-1990 sentence denotes Thus, extracellular epithelial-mesenchymal crosstalk must be intricately orchestrated to couple the determination of distinct cell fates with the contemporaneous remodeling of the physical and structural properties of the cell.
T1324 1763-1767 RB denotes Thus
T1326 1767-1769 , denotes ,
T1327 1769-1782 JJ denotes extracellular
T1329 1783-1793 JJ denotes epithelial
T1331 1793-1794 HYPH denotes -
T1330 1794-1805 JJ denotes mesenchymal
T1328 1806-1815 NN denotes crosstalk
T1332 1816-1820 MD denotes must
T1333 1821-1823 VB denotes be
T1334 1824-1835 RB denotes intricately
T1325 1836-1848 VBN denotes orchestrated
T1335 1849-1851 TO denotes to
T1336 1852-1858 VB denotes couple
T1337 1859-1862 DT denotes the
T1338 1863-1876 NN denotes determination
T1339 1877-1879 IN denotes of
T1340 1880-1888 JJ denotes distinct
T1342 1889-1893 NN denotes cell
T1341 1894-1899 NNS denotes fates
T1343 1900-1904 IN denotes with
T1344 1905-1908 DT denotes the
T1346 1909-1924 JJ denotes contemporaneous
T1345 1925-1935 NN denotes remodeling
T1347 1936-1938 IN denotes of
T1348 1939-1942 DT denotes the
T1350 1943-1951 JJ denotes physical
T1351 1952-1955 CC denotes and
T1352 1956-1966 JJ denotes structural
T1349 1967-1977 NNS denotes properties
T1353 1978-1980 IN denotes of
T1354 1981-1984 DT denotes the
T1355 1985-1989 NN denotes cell
T1356 1989-1990 . denotes .
T1357 1990-2106 sentence denotes Among the few dispensable organs, hair follicles offer an excellent model system to study epithelial bud formation.
T1358 1991-1996 IN denotes Among
T1360 1997-2000 DT denotes the
T1362 2001-2004 JJ denotes few
T1363 2005-2016 JJ denotes dispensable
T1361 2017-2023 NNS denotes organs
T1364 2023-2025 , denotes ,
T1365 2025-2029 NN denotes hair
T1366 2030-2039 NNS denotes follicles
T1359 2040-2045 VBP denotes offer
T1367 2046-2048 DT denotes an
T1369 2049-2058 JJ denotes excellent
T1370 2059-2064 NN denotes model
T1368 2065-2071 NN denotes system
T1371 2072-2074 TO denotes to
T1372 2075-2080 VB denotes study
T1373 2081-2091 JJ denotes epithelial
T1374 2092-2095 NN denotes bud
T1375 2096-2105 NN denotes formation
T1376 2105-2106 . denotes .
T1377 2106-2190 sentence denotes Mammalian skin epithelium begins as a single sheet of multipotent ectodermal cells.
T1378 2107-2116 JJ denotes Mammalian
T1380 2117-2121 NN denotes skin
T1379 2122-2132 NN denotes epithelium
T1381 2133-2139 VBZ denotes begins
T1382 2140-2142 IN denotes as
T1383 2143-2144 DT denotes a
T1385 2145-2151 JJ denotes single
T1384 2152-2157 NN denotes sheet
T1386 2158-2160 IN denotes of
T1387 2161-2172 JJ denotes multipotent
T1389 2173-2183 JJ denotes ectodermal
T1388 2184-2189 NNS denotes cells
T1390 2189-2190 . denotes .
T1391 2190-2377 sentence denotes During development, specialized mesenchymal cells populate the skin in a spatially defined pattern to initiate the complex epithelial-mesenchymal crosstalk that will specify the bud [3].
T1392 2191-2197 IN denotes During
T1394 2198-2209 NN denotes development
T1395 2209-2211 , denotes ,
T1396 2211-2222 JJ denotes specialized
T1398 2223-2234 JJ denotes mesenchymal
T1397 2235-2240 NNS denotes cells
T1393 2241-2249 VBP denotes populate
T1399 2250-2253 DT denotes the
T1400 2254-2258 NN denotes skin
T1401 2259-2261 IN denotes in
T1402 2262-2263 DT denotes a
T1404 2264-2273 RB denotes spatially
T1405 2274-2281 VBN denotes defined
T1403 2282-2289 NN denotes pattern
T1406 2290-2292 TO denotes to
T1407 2293-2301 VB denotes initiate
T1408 2302-2305 DT denotes the
T1410 2306-2313 JJ denotes complex
T1411 2314-2324 JJ denotes epithelial
T1413 2324-2325 HYPH denotes -
T1412 2325-2336 JJ denotes mesenchymal
T1409 2337-2346 NN denotes crosstalk
T1414 2347-2351 WDT denotes that
T1416 2352-2356 MD denotes will
T1415 2357-2364 VB denotes specify
T1417 2365-2368 DT denotes the
T1418 2369-2372 NN denotes bud
T1419 2373-2374 -LRB- denotes [
T1420 2374-2375 CD denotes 3
T1421 2375-2376 -RRB- denotes ]
T1422 2376-2377 . denotes .
T1423 2377-2598 sentence denotes Once committed, a small cluster of epithelial cells, the placode, instructs a group of underlying mesenchymal cells to condense and form the nascent dermal papilla, which will be a permanent fixture of the hair follicle.
T1424 2378-2382 IN denotes Once
T1425 2383-2392 VBN denotes committed
T1427 2392-2394 , denotes ,
T1428 2394-2395 DT denotes a
T1430 2396-2401 JJ denotes small
T1429 2402-2409 NN denotes cluster
T1431 2410-2412 IN denotes of
T1432 2413-2423 JJ denotes epithelial
T1433 2424-2429 NNS denotes cells
T1434 2429-2431 , denotes ,
T1435 2431-2434 DT denotes the
T1436 2435-2442 NN denotes placode
T1437 2442-2444 , denotes ,
T1426 2444-2453 VBZ denotes instructs
T1438 2454-2455 DT denotes a
T1439 2456-2461 NN denotes group
T1441 2462-2464 IN denotes of
T1442 2465-2475 VBG denotes underlying
T1444 2476-2487 JJ denotes mesenchymal
T1443 2488-2493 NNS denotes cells
T1445 2494-2496 TO denotes to
T1440 2497-2505 VB denotes condense
T1446 2506-2509 CC denotes and
T1447 2510-2514 VB denotes form
T1448 2515-2518 DT denotes the
T1450 2519-2526 JJ denotes nascent
T1451 2527-2533 JJ denotes dermal
T1449 2534-2541 NN denotes papilla
T1452 2541-2543 , denotes ,
T1453 2543-2548 WDT denotes which
T1455 2549-2553 MD denotes will
T1454 2554-2556 VB denotes be
T1456 2557-2558 DT denotes a
T1458 2559-2568 JJ denotes permanent
T1457 2569-2576 NN denotes fixture
T1459 2577-2579 IN denotes of
T1460 2580-2583 DT denotes the
T1462 2584-2588 NN denotes hair
T1461 2589-2597 NN denotes follicle
T1463 2597-2598 . denotes .
T1464 2598-2835 sentence denotes Subsequent exchanges between the placode and nascent dermal papilla result in further growth of the follicle into the underlying dermis, or down-growth, and eventual differentiation into the six concentric layers of the mature follicle.
T1465 2599-2609 JJ denotes Subsequent
T1466 2610-2619 NNS denotes exchanges
T1468 2620-2627 IN denotes between
T1469 2628-2631 DT denotes the
T1470 2632-2639 NN denotes placode
T1471 2640-2643 CC denotes and
T1472 2644-2651 JJ denotes nascent
T1474 2652-2658 JJ denotes dermal
T1473 2659-2666 NN denotes papilla
T1467 2667-2673 VBP denotes result
T1475 2674-2676 IN denotes in
T1476 2677-2684 JJ denotes further
T1477 2685-2691 NN denotes growth
T1478 2692-2694 IN denotes of
T1479 2695-2698 DT denotes the
T1480 2699-2707 NN denotes follicle
T1481 2708-2712 IN denotes into
T1482 2713-2716 DT denotes the
T1484 2717-2727 JJ denotes underlying
T1483 2728-2734 NN denotes dermis
T1485 2734-2736 , denotes ,
T1486 2736-2738 CC denotes or
T1487 2739-2743 JJ denotes down
T1489 2743-2744 HYPH denotes -
T1488 2744-2750 NN denotes growth
T1490 2750-2752 , denotes ,
T1491 2752-2755 CC denotes and
T1492 2756-2764 JJ denotes eventual
T1493 2765-2780 NN denotes differentiation
T1494 2781-2785 IN denotes into
T1495 2786-2789 DT denotes the
T1497 2790-2793 CD denotes six
T1498 2794-2804 JJ denotes concentric
T1496 2805-2811 NNS denotes layers
T1499 2812-2814 IN denotes of
T1500 2815-2818 DT denotes the
T1502 2819-2825 JJ denotes mature
T1501 2826-2834 NN denotes follicle
T1503 2834-2835 . denotes .
T1504 2835-3105 sentence denotes Previously, we delineated how two respective epithelial and mesenchymal signals, Wnts and the BMP-inhibitory factor noggin, function in concert to induce lymphoid enhancer factor-1/β-catenin (LEF-1/β-catenin)-mediated gene transcription within the follicle placode [4].
T1505 2836-2846 RB denotes Previously
T1507 2846-2848 , denotes ,
T1508 2848-2850 PRP denotes we
T1506 2851-2861 VBD denotes delineated
T1509 2862-2865 WRB denotes how
T1511 2866-2869 CD denotes two
T1513 2870-2880 JJ denotes respective
T1514 2881-2891 JJ denotes epithelial
T1515 2892-2895 CC denotes and
T1516 2896-2907 JJ denotes mesenchymal
T1512 2908-2915 NNS denotes signals
T1517 2915-2917 , denotes ,
T1518 2917-2921 NNS denotes Wnts
T1519 2922-2925 CC denotes and
T1520 2926-2929 DT denotes the
T1522 2930-2933 NN denotes BMP
T1524 2933-2934 HYPH denotes -
T1523 2934-2944 JJ denotes inhibitory
T1521 2945-2951 NN denotes factor
T1525 2952-2958 NN denotes noggin
T1526 2958-2960 , denotes ,
T1510 2960-2968 VBP denotes function
T1527 2969-2971 IN denotes in
T1528 2972-2979 NN denotes concert
T1529 2980-2982 TO denotes to
T1530 2983-2989 VB denotes induce
T1531 2990-2998 JJ denotes lymphoid
T1533 2999-3007 NN denotes enhancer
T1532 3008-3014 NN denotes factor
T1535 3014-3015 HYPH denotes -
T1536 3015-3016 CD denotes 1
T1537 3016-3017 HYPH denotes /
T1538 3017-3018 NN denotes β
T1540 3018-3019 HYPH denotes -
T1539 3019-3026 NN denotes catenin
T1541 3027-3028 -LRB- denotes (
T1542 3028-3031 NN denotes LEF
T1543 3031-3032 HYPH denotes -
T1544 3032-3033 CD denotes 1
T1545 3033-3034 HYPH denotes /
T1546 3034-3035 NN denotes β
T1548 3035-3036 HYPH denotes -
T1547 3036-3043 NN denotes catenin
T1549 3043-3044 -RRB- denotes )
T1550 3044-3045 HYPH denotes -
T1534 3045-3053 VBN denotes mediated
T1552 3054-3058 NN denotes gene
T1551 3059-3072 NN denotes transcription
T1553 3073-3079 IN denotes within
T1554 3080-3083 DT denotes the
T1556 3084-3092 NN denotes follicle
T1555 3093-3100 NN denotes placode
T1557 3101-3102 -LRB- denotes [
T1558 3102-3103 CD denotes 4
T1559 3103-3104 -RRB- denotes ]
T1560 3104-3105 . denotes .
T1561 3105-3370 sentence denotes The downstream changes elicited through convergence of these two early signaling pathways include down-regulation of the gene encoding E-cadherin, the prototypical epithelial cadherin that forms the transmembrane core of intercellular adherens junctions (AJs) [5].
T1562 3106-3109 DT denotes The
T1564 3110-3120 JJ denotes downstream
T1563 3121-3128 NNS denotes changes
T1566 3129-3137 VBN denotes elicited
T1567 3138-3145 IN denotes through
T1568 3146-3157 NN denotes convergence
T1569 3158-3160 IN denotes of
T1570 3161-3166 DT denotes these
T1572 3167-3170 CD denotes two
T1573 3171-3176 JJ denotes early
T1574 3177-3186 NN denotes signaling
T1571 3187-3195 NNS denotes pathways
T1565 3196-3203 VBP denotes include
T1575 3204-3208 JJ denotes down
T1577 3208-3209 HYPH denotes -
T1576 3209-3219 NN denotes regulation
T1578 3220-3222 IN denotes of
T1579 3223-3226 DT denotes the
T1580 3227-3231 NN denotes gene
T1581 3232-3240 VBG denotes encoding
T1582 3241-3242 NN denotes E
T1584 3242-3243 HYPH denotes -
T1583 3243-3251 NN denotes cadherin
T1585 3251-3253 , denotes ,
T1586 3253-3256 DT denotes the
T1588 3257-3269 JJ denotes prototypical
T1589 3270-3280 JJ denotes epithelial
T1587 3281-3289 NN denotes cadherin
T1590 3290-3294 WDT denotes that
T1591 3295-3300 VBZ denotes forms
T1592 3301-3304 DT denotes the
T1594 3305-3318 JJ denotes transmembrane
T1593 3319-3323 NN denotes core
T1595 3324-3326 IN denotes of
T1596 3327-3340 JJ denotes intercellular
T1598 3341-3349 NN denotes adherens
T1597 3350-3359 NNS denotes junctions
T1599 3360-3361 -LRB- denotes (
T1600 3361-3364 NNS denotes AJs
T1601 3364-3365 -RRB- denotes )
T1602 3366-3367 -LRB- denotes [
T1603 3367-3368 CD denotes 5
T1604 3368-3369 -RRB- denotes ]
T1605 3369-3370 . denotes .
T1606 3370-3635 sentence denotes We subsequently showed that when E-cadherin is transgenically elevated in mouse skin, hair follicle morphogenesis is blocked, suggesting that E-cadherin down-regulation is a critical event in governing the adhesion dynamics necessary for budding morphogenesis [4].
T1607 3371-3373 PRP denotes We
T1609 3374-3386 RB denotes subsequently
T1608 3387-3393 VBD denotes showed
T1610 3394-3398 IN denotes that
T1612 3399-3403 WRB denotes when
T1614 3404-3405 NN denotes E
T1616 3405-3406 HYPH denotes -
T1615 3406-3414 NN denotes cadherin
T1617 3415-3417 VBZ denotes is
T1618 3418-3432 RB denotes transgenically
T1613 3433-3441 VBN denotes elevated
T1619 3442-3444 IN denotes in
T1620 3445-3450 NN denotes mouse
T1621 3451-3455 NN denotes skin
T1622 3455-3457 , denotes ,
T1623 3457-3461 NN denotes hair
T1624 3462-3470 NN denotes follicle
T1625 3471-3484 NN denotes morphogenesis
T1626 3485-3487 VBZ denotes is
T1611 3488-3495 VBN denotes blocked
T1627 3495-3497 , denotes ,
T1628 3497-3507 VBG denotes suggesting
T1629 3508-3512 IN denotes that
T1631 3513-3514 NN denotes E
T1633 3514-3515 HYPH denotes -
T1632 3515-3523 NN denotes cadherin
T1635 3524-3528 JJ denotes down
T1636 3528-3529 HYPH denotes -
T1634 3529-3539 NN denotes regulation
T1630 3540-3542 VBZ denotes is
T1637 3543-3544 DT denotes a
T1639 3545-3553 JJ denotes critical
T1638 3554-3559 NN denotes event
T1640 3560-3562 IN denotes in
T1641 3563-3572 VBG denotes governing
T1642 3573-3576 DT denotes the
T1644 3577-3585 NN denotes adhesion
T1643 3586-3594 NNS denotes dynamics
T1645 3595-3604 JJ denotes necessary
T1646 3605-3608 IN denotes for
T1647 3609-3616 NN denotes budding
T1648 3617-3630 NN denotes morphogenesis
T1649 3631-3632 -LRB- denotes [
T1650 3632-3633 CD denotes 4
T1651 3633-3634 -RRB- denotes ]
T1652 3634-3635 . denotes .
T1653 3635-3683 sentence denotes Like LEF-1, E-cadherin also binds to β-catenin.
T1654 3636-3640 IN denotes Like
T1656 3641-3644 NN denotes LEF
T1657 3644-3645 HYPH denotes -
T1658 3645-3646 CD denotes 1
T1659 3646-3648 , denotes ,
T1660 3648-3649 NN denotes E
T1662 3649-3650 HYPH denotes -
T1661 3650-3658 NN denotes cadherin
T1663 3659-3663 RB denotes also
T1655 3664-3669 VBZ denotes binds
T1664 3670-3672 IN denotes to
T1665 3673-3674 NN denotes β
T1667 3674-3675 HYPH denotes -
T1666 3675-3682 NN denotes catenin
T1668 3682-3683 . denotes .
T1669 3683-3946 sentence denotes At sites of cell-cell contact, however, E-cadherin-β-catenin complexes recruit α-catenin, which in turn coordinates the associated actin polymerization dynamics necessary to stabilize nascent AJs and integrate the cytoskeleton across an epithelial sheet [6,7,8].
T1670 3684-3686 IN denotes At
T1672 3687-3692 NNS denotes sites
T1673 3693-3695 IN denotes of
T1674 3696-3700 NN denotes cell
T1676 3700-3701 HYPH denotes -
T1675 3701-3705 NN denotes cell
T1677 3706-3713 NN denotes contact
T1678 3713-3715 , denotes ,
T1679 3715-3722 RB denotes however
T1680 3722-3724 , denotes ,
T1681 3724-3725 NN denotes E
T1683 3725-3726 HYPH denotes -
T1682 3726-3734 NN denotes cadherin
T1685 3734-3735 HYPH denotes -
T1686 3735-3736 NN denotes β
T1688 3736-3737 HYPH denotes -
T1687 3737-3744 NN denotes catenin
T1684 3745-3754 NNS denotes complexes
T1671 3755-3762 VBP denotes recruit
T1689 3763-3764 NN denotes α
T1691 3764-3765 HYPH denotes -
T1690 3765-3772 NN denotes catenin
T1692 3772-3774 , denotes ,
T1693 3774-3779 WDT denotes which
T1695 3780-3782 IN denotes in
T1696 3783-3787 NN denotes turn
T1694 3788-3799 VBZ denotes coordinates
T1697 3800-3803 DT denotes the
T1699 3804-3814 VBN denotes associated
T1700 3815-3820 NN denotes actin
T1701 3821-3835 NN denotes polymerization
T1698 3836-3844 NNS denotes dynamics
T1702 3845-3854 JJ denotes necessary
T1703 3855-3857 TO denotes to
T1704 3858-3867 VB denotes stabilize
T1705 3868-3875 JJ denotes nascent
T1706 3876-3879 NNS denotes AJs
T1707 3880-3883 CC denotes and
T1708 3884-3893 VB denotes integrate
T1709 3894-3897 DT denotes the
T1710 3898-3910 NN denotes cytoskeleton
T1711 3911-3917 IN denotes across
T1712 3918-3920 DT denotes an
T1714 3921-3931 JJ denotes epithelial
T1713 3932-3937 NN denotes sheet
T1715 3938-3939 -LRB- denotes [
T1717 3939-3940 CD denotes 6
T1718 3940-3941 , denotes ,
T1719 3941-3942 CD denotes 7
T1720 3942-3943 , denotes ,
T1716 3943-3944 CD denotes 8
T1721 3944-3945 -RRB- denotes ]
T1722 3945-3946 . denotes .
T1723 3946-4203 sentence denotes α-Catenin also binds to the class III Lin-1, Isl-1, Mec-3 (LIM) protein Ajuba (a member of the zyxin family of proteins), which appears to function dually in both adhesion and in activation of the Ras-mitogen-activated protein kinase (MAPK) pathway [9,10].
T1724 3947-3948 NN denotes α
T1726 3948-3949 HYPH denotes -
T1725 3949-3956 NN denotes Catenin
T1728 3957-3961 RB denotes also
T1727 3962-3967 VBZ denotes binds
T1729 3968-3970 IN denotes to
T1730 3971-3974 DT denotes the
T1732 3975-3980 NN denotes class
T1733 3981-3984 CD denotes III
T1734 3985-3988 NN denotes Lin
T1735 3988-3989 HYPH denotes -
T1736 3989-3990 CD denotes 1
T1737 3990-3992 , denotes ,
T1738 3992-3995 NN denotes Isl
T1739 3995-3996 HYPH denotes -
T1740 3996-3997 CD denotes 1
T1741 3997-3999 , denotes ,
T1742 3999-4002 NN denotes Mec
T1743 4002-4003 HYPH denotes -
T1744 4003-4004 CD denotes 3
T1745 4005-4006 -LRB- denotes (
T1746 4006-4009 NN denotes LIM
T1747 4009-4010 -RRB- denotes )
T1731 4011-4018 NN denotes protein
T1748 4019-4024 NN denotes Ajuba
T1749 4025-4026 -LRB- denotes (
T1750 4026-4027 DT denotes a
T1751 4028-4034 NN denotes member
T1752 4035-4037 IN denotes of
T1753 4038-4041 DT denotes the
T1755 4042-4047 NN denotes zyxin
T1754 4048-4054 NN denotes family
T1756 4055-4057 IN denotes of
T1757 4058-4066 NN denotes proteins
T1758 4066-4067 -RRB- denotes )
T1759 4067-4069 , denotes ,
T1760 4069-4074 WDT denotes which
T1761 4075-4082 VBZ denotes appears
T1762 4083-4085 TO denotes to
T1763 4086-4094 VB denotes function
T1764 4095-4101 RB denotes dually
T1765 4102-4104 IN denotes in
T1766 4105-4109 CC denotes both
T1767 4110-4118 NN denotes adhesion
T1768 4119-4122 CC denotes and
T1769 4123-4125 IN denotes in
T1770 4126-4136 NN denotes activation
T1771 4137-4139 IN denotes of
T1772 4140-4143 DT denotes the
T1774 4144-4147 NN denotes Ras
T1775 4147-4148 HYPH denotes -
T1776 4148-4155 NN denotes mitogen
T1778 4155-4156 HYPH denotes -
T1777 4156-4165 VBN denotes activated
T1780 4166-4173 NN denotes protein
T1779 4174-4180 NN denotes kinase
T1781 4181-4182 -LRB- denotes (
T1782 4182-4186 NN denotes MAPK
T1783 4186-4187 -RRB- denotes )
T1773 4188-4195 NN denotes pathway
T1784 4196-4197 -LRB- denotes [
T1786 4197-4198 CD denotes 9
T1787 4198-4199 , denotes ,
T1785 4199-4201 CD denotes 10
T1788 4201-4202 -RRB- denotes ]
T1789 4202-4203 . denotes .
T1790 4203-4337 sentence denotes Through these links, AJs appear able to couple adhesion with cytoskeletal dynamics as well as with nuclear and cytoplasmic signaling.
T1791 4204-4211 IN denotes Through
T1793 4212-4217 DT denotes these
T1794 4218-4223 NNS denotes links
T1795 4223-4225 , denotes ,
T1796 4225-4228 NNS denotes AJs
T1792 4229-4235 VBP denotes appear
T1797 4236-4240 JJ denotes able
T1798 4241-4243 TO denotes to
T1799 4244-4250 VB denotes couple
T1800 4251-4259 NN denotes adhesion
T1801 4260-4264 IN denotes with
T1802 4265-4277 JJ denotes cytoskeletal
T1803 4278-4286 NNS denotes dynamics
T1804 4287-4289 RB denotes as
T1806 4290-4294 RB denotes well
T1805 4295-4297 IN denotes as
T1807 4298-4302 IN denotes with
T1808 4303-4310 JJ denotes nuclear
T1810 4311-4314 CC denotes and
T1811 4315-4326 JJ denotes cytoplasmic
T1809 4327-4336 NN denotes signaling
T1812 4336-4337 . denotes .
T1813 4337-4485 sentence denotes This provides a framework for conceptualizing why E-cadherin levels appear to impact upon a plethora of developmental processes (reviewed in [11]).
T1814 4338-4342 DT denotes This
T1815 4343-4351 VBZ denotes provides
T1816 4352-4353 DT denotes a
T1817 4354-4363 NN denotes framework
T1818 4364-4367 IN denotes for
T1819 4368-4383 VBG denotes conceptualizing
T1820 4384-4387 WRB denotes why
T1822 4388-4389 NN denotes E
T1824 4389-4390 HYPH denotes -
T1823 4390-4398 NN denotes cadherin
T1825 4399-4405 NNS denotes levels
T1821 4406-4412 VBP denotes appear
T1826 4413-4415 TO denotes to
T1827 4416-4422 VB denotes impact
T1828 4423-4427 IN denotes upon
T1829 4428-4429 DT denotes a
T1830 4430-4438 NN denotes plethora
T1831 4439-4441 IN denotes of
T1832 4442-4455 JJ denotes developmental
T1833 4456-4465 NNS denotes processes
T1834 4466-4467 -LRB- denotes (
T1835 4467-4475 VBN denotes reviewed
T1836 4476-4478 IN denotes in
T1837 4479-4480 -LRB- denotes [
T1838 4480-4482 CD denotes 11
T1839 4482-4483 -RRB- denotes ]
T1840 4483-4484 -RRB- denotes )
T1841 4484-4485 . denotes .
T1842 4485-4769 sentence denotes As we probed more deeply into the underlying mechanisms governing E-cadherin promoter activity, we were intrigued by the close proximity of the LEF-1/β-catenin binding site to a site known to bind the Snail/Slug family of zinc finger transcriptional repressor proteins [12,13,14,15].
T1843 4486-4488 IN denotes As
T1845 4489-4491 PRP denotes we
T1844 4492-4498 VBD denotes probed
T1847 4499-4503 RBR denotes more
T1848 4504-4510 RB denotes deeply
T1849 4511-4515 IN denotes into
T1850 4516-4519 DT denotes the
T1852 4520-4530 JJ denotes underlying
T1851 4531-4541 NNS denotes mechanisms
T1853 4542-4551 VBG denotes governing
T1854 4552-4553 NN denotes E
T1856 4553-4554 HYPH denotes -
T1855 4554-4562 NN denotes cadherin
T1857 4563-4571 NN denotes promoter
T1858 4572-4580 NN denotes activity
T1859 4580-4582 , denotes ,
T1860 4582-4584 PRP denotes we
T1861 4585-4589 VBD denotes were
T1846 4590-4599 VBN denotes intrigued
T1862 4600-4602 IN denotes by
T1863 4603-4606 DT denotes the
T1865 4607-4612 JJ denotes close
T1864 4613-4622 NN denotes proximity
T1866 4623-4625 IN denotes of
T1867 4626-4629 DT denotes the
T1869 4630-4633 NN denotes LEF
T1870 4633-4634 HYPH denotes -
T1871 4634-4635 CD denotes 1
T1872 4635-4636 HYPH denotes /
T1873 4636-4637 NN denotes β
T1875 4637-4638 HYPH denotes -
T1874 4638-4645 NN denotes catenin
T1876 4646-4653 NN denotes binding
T1868 4654-4658 NN denotes site
T1877 4659-4661 IN denotes to
T1878 4662-4663 DT denotes a
T1879 4664-4668 NN denotes site
T1880 4669-4674 VBN denotes known
T1881 4675-4677 TO denotes to
T1882 4678-4682 VB denotes bind
T1883 4683-4686 DT denotes the
T1885 4687-4692 NN denotes Snail
T1887 4692-4693 HYPH denotes /
T1886 4693-4697 NN denotes Slug
T1884 4698-4704 NN denotes family
T1888 4705-4707 IN denotes of
T1889 4708-4712 NN denotes zinc
T1890 4713-4719 NN denotes finger
T1892 4720-4735 JJ denotes transcriptional
T1893 4736-4745 NN denotes repressor
T1891 4746-4754 NN denotes proteins
T1894 4755-4756 -LRB- denotes [
T1896 4756-4758 CD denotes 12
T1897 4758-4759 , denotes ,
T1898 4759-4761 CD denotes 13
T1899 4761-4762 , denotes ,
T1900 4762-4764 CD denotes 14
T1901 4764-4765 , denotes ,
T1895 4765-4767 CD denotes 15
T1902 4767-4768 -RRB- denotes ]
T1903 4768-4769 . denotes .
T1904 4769-5004 sentence denotes Both activity of Snail and down-regulation of E-cadherin play pivotal roles in epithelial to mesenchymal transitions (EMTs), typified by the transformation of polarized, adhering epithelial cells into motile mesenchymal cells [16,17].
T1905 4770-4774 CC denotes Both
T1906 4775-4783 NN denotes activity
T1908 4784-4786 IN denotes of
T1909 4787-4792 NN denotes Snail
T1910 4793-4796 CC denotes and
T1911 4797-4801 NN denotes down
T1913 4801-4802 HYPH denotes -
T1912 4802-4812 NN denotes regulation
T1914 4813-4815 IN denotes of
T1915 4816-4817 NN denotes E
T1917 4817-4818 HYPH denotes -
T1916 4818-4826 NN denotes cadherin
T1907 4827-4831 VBP denotes play
T1918 4832-4839 JJ denotes pivotal
T1919 4840-4845 NNS denotes roles
T1920 4846-4848 IN denotes in
T1921 4849-4859 JJ denotes epithelial
T1923 4860-4862 IN denotes to
T1924 4863-4874 JJ denotes mesenchymal
T1922 4875-4886 NNS denotes transitions
T1925 4887-4888 -LRB- denotes (
T1926 4888-4892 NNS denotes EMTs
T1927 4892-4893 -RRB- denotes )
T1928 4893-4895 , denotes ,
T1929 4895-4903 VBN denotes typified
T1930 4904-4906 IN denotes by
T1931 4907-4910 DT denotes the
T1932 4911-4925 NN denotes transformation
T1933 4926-4928 IN denotes of
T1934 4929-4938 VBN denotes polarized
T1936 4938-4940 , denotes ,
T1937 4940-4948 VBG denotes adhering
T1938 4949-4959 JJ denotes epithelial
T1935 4960-4965 NNS denotes cells
T1939 4966-4970 IN denotes into
T1940 4971-4977 JJ denotes motile
T1942 4978-4989 JJ denotes mesenchymal
T1941 4990-4995 NNS denotes cells
T1943 4996-4997 -LRB- denotes [
T1945 4997-4999 CD denotes 16
T1946 4999-5000 , denotes ,
T1944 5000-5002 CD denotes 17
T1947 5002-5003 -RRB- denotes ]
T1948 5003-5004 . denotes .
T1949 5004-5190 sentence denotes Bud formation differs from an EMT in that E-cadherin activity needs to be down-regulated but not prevented, so that adhesive junctions are remodeled rather than quantitatively impaired.
T1950 5005-5008 NN denotes Bud
T1951 5009-5018 NN denotes formation
T1952 5019-5026 VBZ denotes differs
T1953 5027-5031 IN denotes from
T1954 5032-5034 DT denotes an
T1955 5035-5038 NN denotes EMT
T1956 5039-5041 IN denotes in
T1958 5042-5046 DT denotes that
T1959 5047-5048 NN denotes E
T1961 5048-5049 HYPH denotes -
T1960 5049-5057 NN denotes cadherin
T1962 5058-5066 NN denotes activity
T1957 5067-5072 VBZ denotes needs
T1963 5073-5075 TO denotes to
T1965 5076-5078 VB denotes be
T1966 5079-5083 RB denotes down
T1967 5083-5084 HYPH denotes -
T1964 5084-5093 VBN denotes regulated
T1968 5094-5097 CC denotes but
T1969 5098-5101 RB denotes not
T1970 5102-5111 VBN denotes prevented
T1971 5111-5113 , denotes ,
T1972 5113-5115 IN denotes so
T1974 5116-5120 IN denotes that
T1975 5121-5129 JJ denotes adhesive
T1976 5130-5139 NNS denotes junctions
T1977 5140-5143 VBP denotes are
T1973 5144-5153 VBN denotes remodeled
T1978 5154-5160 RB denotes rather
T1979 5161-5165 IN denotes than
T1980 5166-5180 RB denotes quantitatively
T1981 5181-5189 VBN denotes impaired
T1982 5189-5190 . denotes .
T1983 5190-5408 sentence denotes Supportive of an underlying ability to fine-tune cadherin expression at the transcriptional level, Snail seems to have an additive effect with LEF-1/β-catenin in negatively modulating E-cadherin promoter activity [4].
T1984 5191-5201 JJ denotes Supportive
T1986 5202-5204 IN denotes of
T1987 5205-5207 DT denotes an
T1989 5208-5218 JJ denotes underlying
T1988 5219-5226 NN denotes ability
T1990 5227-5229 TO denotes to
T1992 5230-5234 RB denotes fine
T1993 5234-5235 HYPH denotes -
T1991 5235-5239 VB denotes tune
T1994 5240-5248 NN denotes cadherin
T1995 5249-5259 NN denotes expression
T1996 5260-5262 IN denotes at
T1997 5263-5266 DT denotes the
T1999 5267-5282 JJ denotes transcriptional
T1998 5283-5288 NN denotes level
T2000 5288-5290 , denotes ,
T2001 5290-5295 NN denotes Snail
T1985 5296-5301 VBZ denotes seems
T2002 5302-5304 TO denotes to
T2003 5305-5309 VB denotes have
T2004 5310-5312 DT denotes an
T2006 5313-5321 JJ denotes additive
T2005 5322-5328 NN denotes effect
T2007 5329-5333 IN denotes with
T2008 5334-5337 NN denotes LEF
T2009 5337-5338 HYPH denotes -
T2010 5338-5339 CD denotes 1
T2011 5339-5340 HYPH denotes /
T2012 5340-5341 NN denotes β
T2014 5341-5342 HYPH denotes -
T2013 5342-5349 NN denotes catenin
T2015 5350-5352 IN denotes in
T2016 5353-5363 RB denotes negatively
T2017 5364-5374 VBG denotes modulating
T2018 5375-5376 NN denotes E
T2020 5376-5377 HYPH denotes -
T2019 5377-5385 NN denotes cadherin
T2021 5386-5394 NN denotes promoter
T2022 5395-5403 NN denotes activity
T2023 5404-5405 -LRB- denotes [
T2024 5405-5406 CD denotes 4
T2025 5406-5407 -RRB- denotes ]
T2026 5407-5408 . denotes .
T2027 5408-5593 sentence denotes In the present study, we discovered that Snail is expressed briefly at an early stage of hair bud formation, when E-cadherin down-regulation and activation of proliferation take place.
T2028 5409-5411 IN denotes In
T2030 5412-5415 DT denotes the
T2032 5416-5423 JJ denotes present
T2031 5424-5429 NN denotes study
T2033 5429-5431 , denotes ,
T2034 5431-5433 PRP denotes we
T2029 5434-5444 VBD denotes discovered
T2035 5445-5449 IN denotes that
T2037 5450-5455 NN denotes Snail
T2038 5456-5458 VBZ denotes is
T2036 5459-5468 VBN denotes expressed
T2039 5469-5476 RB denotes briefly
T2040 5477-5479 IN denotes at
T2041 5480-5482 DT denotes an
T2043 5483-5488 JJ denotes early
T2042 5489-5494 NN denotes stage
T2044 5495-5497 IN denotes of
T2045 5498-5502 NN denotes hair
T2046 5503-5506 NN denotes bud
T2047 5507-5516 NN denotes formation
T2048 5516-5518 , denotes ,
T2049 5518-5522 WRB denotes when
T2051 5523-5524 NN denotes E
T2053 5524-5525 HYPH denotes -
T2052 5525-5533 NN denotes cadherin
T2054 5534-5538 JJ denotes down
T2056 5538-5539 HYPH denotes -
T2055 5539-5549 NN denotes regulation
T2057 5550-5553 CC denotes and
T2058 5554-5564 NN denotes activation
T2059 5565-5567 IN denotes of
T2060 5568-5581 NN denotes proliferation
T2050 5582-5586 VBP denotes take
T2061 5587-5592 NN denotes place
T2062 5592-5593 . denotes .
T2063 5593-5696 sentence denotes Thereafter, Snail disappears and remains absent during subsequent follicle down-growth and maturation.
T2064 5594-5604 RB denotes Thereafter
T2066 5604-5606 , denotes ,
T2067 5606-5611 NN denotes Snail
T2065 5612-5622 VBZ denotes disappears
T2068 5623-5626 CC denotes and
T2069 5627-5634 VBZ denotes remains
T2070 5635-5641 JJ denotes absent
T2071 5642-5648 IN denotes during
T2072 5649-5659 JJ denotes subsequent
T2074 5660-5668 NN denotes follicle
T2075 5669-5673 JJ denotes down
T2076 5673-5674 HYPH denotes -
T2073 5674-5680 NN denotes growth
T2077 5681-5684 CC denotes and
T2078 5685-5695 NN denotes maturation
T2079 5695-5696 . denotes .
T2080 5696-5956 sentence denotes This exquisite pattern appears to be functionally relevant since altering it in vivo correspondingly affects features associated with hair bud formation, including down-regulation of E-cadherin, increased proliferation, and repressed terminal differentiation.
T2081 5697-5701 DT denotes This
T2083 5702-5711 JJ denotes exquisite
T2082 5712-5719 NN denotes pattern
T2084 5720-5727 VBZ denotes appears
T2085 5728-5730 TO denotes to
T2086 5731-5733 VB denotes be
T2087 5734-5746 RB denotes functionally
T2088 5747-5755 JJ denotes relevant
T2089 5756-5761 IN denotes since
T2091 5762-5770 VBG denotes altering
T2092 5771-5773 PRP denotes it
T2093 5774-5776 FW denotes in
T2094 5777-5781 FW denotes vivo
T2095 5782-5797 RB denotes correspondingly
T2090 5798-5805 VBZ denotes affects
T2096 5806-5814 NNS denotes features
T2097 5815-5825 VBN denotes associated
T2098 5826-5830 IN denotes with
T2099 5831-5835 NN denotes hair
T2100 5836-5839 NN denotes bud
T2101 5840-5849 NN denotes formation
T2102 5849-5851 , denotes ,
T2103 5851-5860 VBG denotes including
T2104 5861-5865 NN denotes down
T2106 5865-5866 HYPH denotes -
T2105 5866-5876 NN denotes regulation
T2107 5877-5879 IN denotes of
T2108 5880-5881 NN denotes E
T2110 5881-5882 HYPH denotes -
T2109 5882-5890 NN denotes cadherin
T2111 5890-5892 , denotes ,
T2112 5892-5901 VBN denotes increased
T2113 5902-5915 NN denotes proliferation
T2114 5915-5917 , denotes ,
T2115 5917-5920 CC denotes and
T2116 5921-5930 VBN denotes repressed
T2118 5931-5939 JJ denotes terminal
T2117 5940-5955 NN denotes differentiation
T2119 5955-5956 . denotes .
T2120 5956-6202 sentence denotes Although the temporal spike of Snail in the hair bud is reflected at the mRNA level and seems to follow Wnt signaling and BMP inhibition, LEF-1/β-catenin activation does not appear to induce Snail gene expression in embryonic skin keratinocytes.
T2121 5957-5965 IN denotes Although
T2123 5966-5969 DT denotes the
T2125 5970-5978 JJ denotes temporal
T2124 5979-5984 NN denotes spike
T2126 5985-5987 IN denotes of
T2127 5988-5993 NN denotes Snail
T2128 5994-5996 IN denotes in
T2129 5997-6000 DT denotes the
T2131 6001-6005 NN denotes hair
T2130 6006-6009 NN denotes bud
T2132 6010-6012 VBZ denotes is
T2122 6013-6022 VBN denotes reflected
T2134 6023-6025 IN denotes at
T2135 6026-6029 DT denotes the
T2137 6030-6034 NN denotes mRNA
T2136 6035-6040 NN denotes level
T2138 6041-6044 CC denotes and
T2139 6045-6050 VBZ denotes seems
T2140 6051-6053 TO denotes to
T2141 6054-6060 VB denotes follow
T2142 6061-6064 NN denotes Wnt
T2143 6065-6074 NN denotes signaling
T2144 6075-6078 CC denotes and
T2145 6079-6082 NN denotes BMP
T2146 6083-6093 NN denotes inhibition
T2147 6093-6095 , denotes ,
T2148 6095-6098 NN denotes LEF
T2150 6098-6099 HYPH denotes -
T2151 6099-6100 CD denotes 1
T2152 6100-6101 HYPH denotes /
T2153 6101-6102 NN denotes β
T2155 6102-6103 HYPH denotes -
T2154 6103-6110 NN denotes catenin
T2149 6111-6121 NN denotes activation
T2156 6122-6126 VBZ denotes does
T2157 6127-6130 RB denotes not
T2133 6131-6137 VB denotes appear
T2158 6138-6140 TO denotes to
T2159 6141-6147 VB denotes induce
T2160 6148-6153 NN denotes Snail
T2162 6154-6158 NN denotes gene
T2161 6159-6169 NN denotes expression
T2163 6170-6172 IN denotes in
T2164 6173-6182 JJ denotes embryonic
T2166 6183-6187 NN denotes skin
T2165 6188-6201 NNS denotes keratinocytes
T2167 6201-6202 . denotes .
T2168 6202-6461 sentence denotes In contrast, we provide in vitro, transgenic (Tg), and gene targeting evidence to show that TGF-β2 and small phenotype– and mothers against decapentaplegic–related protein 2 (SMAD2) signaling are upstream inducers of Snail gene expression in skin epithelium.
T2169 6203-6205 IN denotes In
T2171 6206-6214 NN denotes contrast
T2172 6214-6216 , denotes ,
T2173 6216-6218 PRP denotes we
T2170 6219-6226 VBP denotes provide
T2174 6227-6229 FW denotes in
T2175 6230-6235 FW denotes vitro
T2177 6235-6237 , denotes ,
T2178 6237-6247 JJ denotes transgenic
T2179 6248-6249 -LRB- denotes (
T2180 6249-6251 JJ denotes Tg
T2181 6251-6252 -RRB- denotes )
T2182 6252-6254 , denotes ,
T2183 6254-6257 CC denotes and
T2184 6258-6262 NN denotes gene
T2185 6263-6272 VBG denotes targeting
T2176 6273-6281 NN denotes evidence
T2186 6282-6284 TO denotes to
T2187 6285-6289 VB denotes show
T2188 6290-6294 IN denotes that
T2190 6295-6298 NN denotes TGF
T2192 6298-6299 HYPH denotes -
T2191 6299-6301 NN denotes β2
T2194 6302-6305 CC denotes and
T2195 6306-6311 JJ denotes small
T2196 6312-6321 NN denotes phenotype
T2198 6321-6322 -LRB- denotes –
T2199 6323-6326 CC denotes and
T2200 6327-6334 NNS denotes mothers
T2201 6335-6342 IN denotes against
T2202 6343-6358 NN denotes decapentaplegic
T2203 6358-6359 -RRB- denotes –
T2197 6359-6366 VBN denotes related
T2204 6367-6374 NN denotes protein
T2205 6375-6376 CD denotes 2
T2206 6377-6378 -LRB- denotes (
T2207 6378-6383 NN denotes SMAD2
T2208 6383-6384 -RRB- denotes )
T2193 6385-6394 NN denotes signaling
T2189 6395-6398 VBP denotes are
T2209 6399-6407 JJ denotes upstream
T2210 6408-6416 NNS denotes inducers
T2211 6417-6419 IN denotes of
T2212 6420-6425 NN denotes Snail
T2214 6426-6430 NN denotes gene
T2213 6431-6441 NN denotes expression
T2215 6442-6444 IN denotes in
T2216 6445-6449 NN denotes skin
T2217 6450-6460 NN denotes epithelium
T2218 6460-6461 . denotes .
T2219 6461-6592 sentence denotes In the absence of TGF-β2 signaling and Snail gene expression, hair placodes can form, but further follicle down-growth is blocked.
T2220 6462-6464 IN denotes In
T2222 6465-6468 DT denotes the
T2223 6469-6476 NN denotes absence
T2224 6477-6479 IN denotes of
T2225 6480-6483 NN denotes TGF
T2227 6483-6484 HYPH denotes -
T2226 6484-6486 NN denotes β2
T2228 6487-6496 NN denotes signaling
T2229 6497-6500 CC denotes and
T2230 6501-6506 NN denotes Snail
T2232 6507-6511 NN denotes gene
T2231 6512-6522 NN denotes expression
T2233 6522-6524 , denotes ,
T2234 6524-6528 NN denotes hair
T2235 6529-6537 NNS denotes placodes
T2236 6538-6541 MD denotes can
T2221 6542-6546 VB denotes form
T2237 6546-6548 , denotes ,
T2238 6548-6551 CC denotes but
T2239 6552-6559 JJ denotes further
T2241 6560-6568 NN denotes follicle
T2242 6569-6573 JJ denotes down
T2243 6573-6574 HYPH denotes -
T2240 6574-6580 NN denotes growth
T2245 6581-6583 VBZ denotes is
T2244 6584-6591 VBN denotes blocked
T2246 6591-6592 . denotes .
T2247 6592-6770 sentence denotes Our studies point to the view that Snail likely functions downstream of cell fate specification, at a stage where the bud begins to exhibit enhanced proliferation and migration.
T2248 6593-6596 PRP$ denotes Our
T2249 6597-6604 NNS denotes studies
T2250 6605-6610 VBP denotes point
T2251 6611-6613 IN denotes to
T2252 6614-6617 DT denotes the
T2253 6618-6622 NN denotes view
T2254 6623-6627 IN denotes that
T2256 6628-6633 NN denotes Snail
T2257 6634-6640 RB denotes likely
T2255 6641-6650 VBZ denotes functions
T2258 6651-6661 RB denotes downstream
T2259 6662-6664 IN denotes of
T2260 6665-6669 NN denotes cell
T2261 6670-6674 NN denotes fate
T2262 6675-6688 NN denotes specification
T2263 6688-6690 , denotes ,
T2264 6690-6692 IN denotes at
T2265 6693-6694 DT denotes a
T2266 6695-6700 NN denotes stage
T2267 6701-6706 WRB denotes where
T2269 6707-6710 DT denotes the
T2270 6711-6714 NN denotes bud
T2268 6715-6721 VBZ denotes begins
T2271 6722-6724 TO denotes to
T2272 6725-6732 VB denotes exhibit
T2273 6733-6741 VBN denotes enhanced
T2274 6742-6755 NN denotes proliferation
T2275 6756-6759 CC denotes and
T2276 6760-6769 NN denotes migration
T2277 6769-6770 . denotes .
R1000 T1864 T1862 pobj proximity,by
R1001 T1865 T1864 amod close,proximity
R1002 T1757 T1756 pobj proteins,of
R1003 T1866 T1864 prep of,proximity
R1004 T1867 T1868 det the,site
R1005 T1758 T1731 punct ),protein
R1006 T1759 T1731 punct ", ",protein
R1007 T1868 T1866 pobj site,of
R1008 T1869 T1868 nmod LEF,site
R1009 T1870 T1869 punct -,LEF
R1010 T1760 T1761 dep which,appears
R1011 T1871 T1869 nummod 1,LEF
R1012 T1872 T1869 punct /,LEF
R1013 T1761 T1731 relcl appears,protein
R1014 T1873 T1874 compound β,catenin
R1015 T1762 T1763 aux to,function
R1016 T1874 T1869 appos catenin,LEF
R1017 T1875 T1874 punct -,catenin
R1018 T1876 T1868 compound binding,site
R1019 T1763 T1761 xcomp function,appears
R1020 T1877 T1864 prep to,proximity
R1021 T1878 T1879 det a,site
R1022 T1879 T1877 pobj site,to
R1023 T1764 T1763 advmod dually,function
R1024 T1880 T1879 acl known,site
R1025 T1881 T1882 aux to,bind
R1026 T1765 T1763 prep in,function
R1027 T1882 T1880 xcomp bind,known
R1028 T1883 T1884 det the,family
R1029 T1884 T1882 dobj family,bind
R1030 T1766 T1765 preconj both,in
R1031 T1767 T1765 conj adhesion,in
R1032 T1768 T1765 cc and,in
R1033 T1769 T1765 conj in,in
R1034 T1885 T1886 compound Snail,Slug
R1035 T1886 T1884 compound Slug,family
R1036 T1770 T1769 pobj activation,in
R1037 T1887 T1886 punct /,Slug
R1038 T1888 T1884 prep of,family
R1039 T1889 T1890 nmod zinc,finger
R1040 T1771 T1770 prep of,activation
R1041 T1890 T1891 nmod finger,proteins
R1042 T1891 T1888 pobj proteins,of
R1043 T1772 T1773 det the,pathway
R1044 T1892 T1893 amod transcriptional,repressor
R1045 T1893 T1891 compound repressor,proteins
R1046 T1894 T1895 punct [,15
R1047 T1773 T1771 pobj pathway,of
R1048 T1895 T1846 parataxis 15,intrigued
R1049 T1896 T1895 nummod 12,15
R1050 T1897 T1895 punct ",",15
R1051 T1898 T1895 nummod 13,15
R1052 T1899 T1895 punct ",",15
R1053 T1900 T1895 nummod 14,15
R1054 T1774 T1773 nmod Ras,pathway
R1055 T1901 T1895 punct ",",15
R1056 T1902 T1895 punct ],15
R1057 T1903 T1846 punct .,intrigued
R1058 T1775 T1774 punct -,Ras
R1059 T1905 T1906 preconj Both,activity
R1060 T1776 T1777 npadvmod mitogen,activated
R1061 T1906 T1907 nsubj activity,play
R1062 T1908 T1906 prep of,activity
R1063 T1777 T1779 amod activated,kinase
R1064 T1909 T1908 pobj Snail,of
R1065 T1910 T1906 cc and,activity
R1066 T1911 T1912 compound down,regulation
R1067 T1778 T1777 punct -,activated
R1068 T1912 T1906 conj regulation,activity
R1069 T1913 T1912 punct -,regulation
R1070 T1914 T1912 prep of,regulation
R1071 T1779 T1774 appos kinase,Ras
R1072 T1915 T1916 compound E,cadherin
R1073 T1916 T1914 pobj cadherin,of
R1074 T1991 T1988 acl tune,ability
R1075 T1917 T1916 punct -,cadherin
R1076 T1918 T1919 amod pivotal,roles
R1077 T1919 T1907 dobj roles,play
R1078 T1920 T1907 prep in,play
R1079 T1992 T1991 advmod fine,tune
R1080 T1921 T1922 amod epithelial,transitions
R1081 T1922 T1920 pobj transitions,in
R1082 T1923 T1921 prep to,epithelial
R1083 T1993 T1991 punct -,tune
R1084 T1924 T1923 amod mesenchymal,to
R1085 T1925 T1922 punct (,transitions
R1086 T1994 T1995 compound cadherin,expression
R1087 T1926 T1922 appos EMTs,transitions
R1088 T1927 T1922 punct ),transitions
R1089 T1928 T1922 punct ", ",transitions
R1090 T1995 T1991 dobj expression,tune
R1091 T1929 T1922 acl typified,transitions
R1092 T1930 T1929 agent by,typified
R1093 T1931 T1932 det the,transformation
R1094 T1996 T1991 prep at,tune
R1095 T1932 T1930 pobj transformation,by
R1096 T1933 T1932 prep of,transformation
R1097 T1934 T1935 amod polarized,cells
R1098 T1997 T1998 det the,level
R1099 T1935 T1933 pobj cells,of
R1100 T1936 T1935 punct ", ",cells
R1101 T1937 T1935 amod adhering,cells
R1102 T1938 T1935 amod epithelial,cells
R1103 T1939 T1932 prep into,transformation
R1104 T1998 T1996 pobj level,at
R1105 T1940 T1941 amod motile,cells
R1106 T1941 T1939 pobj cells,into
R1107 T1999 T1998 amod transcriptional,level
R1108 T1942 T1941 amod mesenchymal,cells
R1109 T1943 T1944 punct [,17
R1110 T1944 T1907 parataxis 17,play
R1111 T2000 T1985 punct ", ",seems
R1112 T1945 T1944 nummod 16,17
R1113 T1946 T1944 punct ",",17
R1114 T1947 T1944 punct ],17
R1115 T2001 T1985 nsubj Snail,seems
R1116 T1948 T1907 punct .,play
R1117 T1950 T1951 compound Bud,formation
R1118 T2002 T2003 aux to,have
R1119 T1951 T1952 nsubj formation,differs
R1120 T2003 T1985 xcomp have,seems
R1121 T1953 T1952 prep from,differs
R1122 T1954 T1955 det an,EMT
R1123 T2004 T2005 det an,effect
R1124 T1955 T1953 pobj EMT,from
R1125 T1956 T1957 mark in,needs
R1126 T2005 T2003 dobj effect,have
R1127 T2006 T2005 amod additive,effect
R1128 T1957 T1952 advcl needs,differs
R1129 T1958 T1957 mark that,needs
R1130 T1959 T1960 compound E,cadherin
R1131 T2007 T2003 prep with,have
R1132 T1960 T1962 compound cadherin,activity
R1133 T1961 T1960 punct -,cadherin
R1134 T1962 T1957 nsubj activity,needs
R1135 T2008 T2007 pobj LEF,with
R1136 T1963 T1964 aux to,regulated
R1137 T1964 T1957 xcomp regulated,needs
R1138 T1965 T1964 aux be,regulated
R1139 T2009 T2008 punct -,LEF
R1140 T1966 T1964 advmod down,regulated
R1141 T1967 T1964 punct -,regulated
R1142 T2010 T2008 nummod 1,LEF
R1143 T1968 T1964 cc but,regulated
R1144 T1969 T1968 neg not,but
R1145 T2011 T2008 punct /,LEF
R1146 T1970 T1964 conj prevented,regulated
R1147 T1971 T1964 punct ", ",regulated
R1148 T1972 T1973 mark so,remodeled
R1149 T2012 T2013 compound β,catenin
R1150 T1973 T1964 advcl remodeled,regulated
R1151 T1974 T1973 mark that,remodeled
R1152 T2013 T2008 appos catenin,LEF
R1153 T1975 T1976 amod adhesive,junctions
R1154 T1976 T1973 nsubjpass junctions,remodeled
R1155 T1977 T1973 auxpass are,remodeled
R1156 T1978 T1979 advmod rather,than
R1157 T1979 T1973 cc than,remodeled
R1158 T1980 T1981 advmod quantitatively,impaired
R1159 T1981 T1973 conj impaired,remodeled
R1160 T2014 T2013 punct -,catenin
R1161 T1982 T1952 punct .,differs
R1162 T2015 T2003 prep in,have
R1163 T1984 T1985 advcl Supportive,seems
R1164 T1986 T1984 prep of,Supportive
R1165 T2016 T2017 advmod negatively,modulating
R1166 T1987 T1988 det an,ability
R1167 T1988 T1986 pobj ability,of
R1168 T1989 T1988 amod underlying,ability
R1169 T2017 T2015 pcomp modulating,in
R1170 T1990 T1991 aux to,tune
R1171 T2018 T2019 compound E,cadherin
R1172 T2019 T2021 compound cadherin,promoter
R1173 T2020 T2019 punct -,cadherin
R1174 T2021 T2022 compound promoter,activity
R1175 T2022 T2017 dobj activity,modulating
R1176 T2023 T2024 punct [,4
R1177 T2097 T2096 acl associated,features
R1178 T2098 T2097 prep with,associated
R1179 T2024 T1985 parataxis 4,seems
R1180 T2099 T2100 compound hair,bud
R1181 T2100 T2101 compound bud,formation
R1182 T2025 T2024 punct ],4
R1183 T2101 T2098 pobj formation,with
R1184 T2102 T2096 punct ", ",features
R1185 T2103 T2096 prep including,features
R1186 T2026 T1985 punct .,seems
R1187 T2104 T2105 compound down,regulation
R1188 T2105 T2103 pobj regulation,including
R1189 T2028 T2029 prep In,discovered
R1190 T2106 T2105 punct -,regulation
R1191 T2107 T2105 prep of,regulation
R1192 T2108 T2109 compound E,cadherin
R1193 T2109 T2107 pobj cadherin,of
R1194 T2030 T2031 det the,study
R1195 T2110 T2109 punct -,cadherin
R1196 T2111 T2105 punct ", ",regulation
R1197 T2112 T2113 amod increased,proliferation
R1198 T2113 T2105 conj proliferation,regulation
R1199 T2031 T2028 pobj study,In
R1200 T2114 T2113 punct ", ",proliferation
R1201 T2115 T2113 cc and,proliferation
R1202 T2032 T2031 amod present,study
R1203 T2116 T2117 amod repressed,differentiation
R1204 T2117 T2113 conj differentiation,proliferation
R1205 T2118 T2117 amod terminal,differentiation
R1206 T2119 T2084 punct .,appears
R1207 T2033 T2029 punct ", ",discovered
R1208 T2121 T2122 mark Although,reflected
R1209 T2034 T2029 nsubj we,discovered
R1210 T2122 T2133 advcl reflected,appear
R1211 T2123 T2124 det the,spike
R1212 T2035 T2036 mark that,expressed
R1213 T2124 T2122 nsubjpass spike,reflected
R1214 T2125 T2124 amod temporal,spike
R1215 T2036 T2029 ccomp expressed,discovered
R1216 T2126 T2124 prep of,spike
R1217 T2127 T2126 pobj Snail,of
R1218 T2037 T2036 nsubjpass Snail,expressed
R1219 T2128 T2124 prep in,spike
R1220 T2129 T2130 det the,bud
R1221 T2130 T2128 pobj bud,in
R1222 T2038 T2036 auxpass is,expressed
R1223 T2131 T2130 compound hair,bud
R1224 T2132 T2122 auxpass is,reflected
R1225 T2039 T2036 advmod briefly,expressed
R1226 T2134 T2122 prep at,reflected
R1227 T2135 T2136 det the,level
R1228 T2136 T2134 pobj level,at
R1229 T2040 T2036 prep at,expressed
R1230 T2137 T2136 compound mRNA,level
R1231 T2138 T2122 cc and,reflected
R1232 T2139 T2122 conj seems,reflected
R1233 T2041 T2042 det an,stage
R1234 T2140 T2141 aux to,follow
R1235 T2141 T2139 xcomp follow,seems
R1236 T2142 T2143 compound Wnt,signaling
R1237 T2042 T2040 pobj stage,at
R1238 T2143 T2141 dobj signaling,follow
R1239 T2144 T2143 cc and,signaling
R1240 T2043 T2042 amod early,stage
R1241 T2145 T2146 compound BMP,inhibition
R1242 T2146 T2143 conj inhibition,signaling
R1243 T2147 T2133 punct ", ",appear
R1244 T2044 T2042 prep of,stage
R1245 T2148 T2149 nmod LEF,activation
R1246 T2149 T2133 nsubj activation,appear
R1247 T2045 T2046 compound hair,bud
R1248 T2150 T2148 punct -,LEF
R1249 T2151 T2148 nummod 1,LEF
R1250 T2152 T2148 punct /,LEF
R1251 T2046 T2047 compound bud,formation
R1252 T2153 T2154 compound β,catenin
R1253 T2154 T2148 appos catenin,LEF
R1254 T2155 T2154 punct -,catenin
R1255 T2047 T2044 pobj formation,of
R1256 T2156 T2133 aux does,appear
R1257 T2157 T2133 neg not,appear
R1258 T2158 T2159 aux to,induce
R1259 T2159 T2133 xcomp induce,appear
R1260 T2160 T2161 compound Snail,expression
R1261 T2161 T2159 dobj expression,induce
R1262 T2162 T2161 compound gene,expression
R1263 T2048 T2042 punct ", ",stage
R1264 T2163 T2159 prep in,induce
R1265 T2164 T2165 amod embryonic,keratinocytes
R1266 T2165 T2163 pobj keratinocytes,in
R1267 T2166 T2165 compound skin,keratinocytes
R1268 T2049 T2050 advmod when,take
R1269 T2167 T2133 punct .,appear
R1270 T2050 T2042 relcl take,stage
R1271 T2169 T2170 prep In,provide
R1272 T2171 T2169 pobj contrast,In
R1273 T2051 T2052 compound E,cadherin
R1274 T2172 T2170 punct ", ",provide
R1275 T2173 T2170 nsubj we,provide
R1276 T2174 T2175 advmod in,vitro
R1277 T2052 T2050 nsubj cadherin,take
R1278 T2175 T2176 amod vitro,evidence
R1279 T2176 T2170 dobj evidence,provide
R1280 T2053 T2052 punct -,cadherin
R1281 T2177 T2175 punct ", ",vitro
R1282 T2178 T2175 conj transgenic,vitro
R1283 T2179 T2180 punct (,Tg
R1284 T2054 T2055 amod down,regulation
R1285 T2180 T2178 parataxis Tg,transgenic
R1286 T2181 T2180 punct ),Tg
R1287 T2182 T2178 punct ", ",transgenic
R1288 T2055 T2052 appos regulation,cadherin
R1289 T2183 T2178 cc and,transgenic
R1290 T2184 T2185 npadvmod gene,targeting
R1291 T2056 T2055 punct -,regulation
R1292 T2185 T2178 conj targeting,transgenic
R1293 T2186 T2187 aux to,show
R1294 T2057 T2055 cc and,regulation
R1295 T2187 T2170 advcl show,provide
R1296 T2188 T2189 mark that,are
R1297 T2058 T2055 conj activation,regulation
R1298 T2059 T2058 prep of,activation
R1299 T2189 T2187 ccomp are,show
R1300 T2190 T2191 nmod TGF,β2
R1301 T2060 T2059 pobj proliferation,of
R1302 T2191 T2193 nmod β2,signaling
R1303 T2192 T2191 punct -,β2
R1304 T2193 T2189 nsubj signaling,are
R1305 T2061 T2050 dobj place,take
R1306 T2194 T2191 cc and,β2
R1307 T2195 T2196 amod small,phenotype
R1308 T2196 T2197 npadvmod phenotype,related
R1309 T2197 T2204 amod related,protein
R1310 T2198 T2196 punct –,phenotype
R1311 T2199 T2196 cc and,phenotype
R1312 T2062 T2029 punct .,discovered
R1313 T2200 T2196 conj mothers,phenotype
R1314 T2201 T2200 prep against,mothers
R1315 T2202 T2201 pobj decapentaplegic,against
R1316 T2064 T2065 advmod Thereafter,disappears
R1317 T2066 T2065 punct ", ",disappears
R1318 T2203 T2197 punct –,related
R1319 T2204 T2191 conj protein,β2
R1320 T2067 T2065 nsubj Snail,disappears
R1321 T2205 T2204 nummod 2,protein
R1322 T2206 T2204 punct (,protein
R1323 T2207 T2204 appos SMAD2,protein
R1324 T2068 T2065 cc and,disappears
R1325 T2208 T2193 punct ),signaling
R1326 T2209 T2210 amod upstream,inducers
R1327 T2069 T2065 conj remains,disappears
R1328 T2210 T2189 attr inducers,are
R1329 T2211 T2210 prep of,inducers
R1330 T2212 T2213 compound Snail,expression
R1331 T2070 T2069 acomp absent,remains
R1332 T2213 T2211 pobj expression,of
R1333 T2214 T2213 compound gene,expression
R1334 T2071 T2069 prep during,remains
R1335 T2215 T2189 prep in,are
R1336 T2216 T2217 compound skin,epithelium
R1337 T2072 T2073 amod subsequent,growth
R1338 T2217 T2215 pobj epithelium,in
R1339 T2218 T2170 punct .,provide
R1340 T2073 T2071 pobj growth,during
R1341 T2220 T2221 prep In,form
R1342 T2074 T2073 nmod follicle,growth
R1343 T2222 T2223 det the,absence
R1344 T2223 T2220 pobj absence,In
R1345 T2075 T2073 amod down,growth
R1346 T2224 T2223 prep of,absence
R1347 T2225 T2226 compound TGF,β2
R1348 T2226 T2228 compound β2,signaling
R1349 T2076 T2073 punct -,growth
R1350 T2227 T2226 punct -,β2
R1351 T2077 T2073 cc and,growth
R1352 T2228 T2224 pobj signaling,of
R1353 T2229 T2228 cc and,signaling
R1354 T2230 T2231 compound Snail,expression
R1355 T2078 T2073 conj maturation,growth
R1356 T2231 T2228 conj expression,signaling
R1357 T2232 T2231 compound gene,expression
R1358 T2079 T2065 punct .,disappears
R1359 T2233 T2221 punct ", ",form
R1360 T2234 T2235 compound hair,placodes
R1361 T2235 T2221 nsubj placodes,form
R1362 T2236 T2221 aux can,form
R1363 T2237 T2221 punct ", ",form
R1364 T2238 T2221 cc but,form
R1365 T2081 T2082 det This,pattern
R1366 T2239 T2240 amod further,growth
R1367 T2240 T2244 nsubjpass growth,blocked
R1368 T2241 T2240 nmod follicle,growth
R1369 T2242 T2240 amod down,growth
R1370 T2082 T2084 nsubj pattern,appears
R1371 T2243 T2240 punct -,growth
R1372 T2244 T2221 conj blocked,form
R1373 T2245 T2244 auxpass is,blocked
R1374 T2083 T2082 amod exquisite,pattern
R1375 T2246 T2221 punct .,form
R1376 T2085 T2086 aux to,be
R1377 T2248 T2249 poss Our,studies
R1378 T2249 T2250 nsubj studies,point
R1379 T2251 T2250 prep to,point
R1380 T2086 T2084 xcomp be,appears
R1381 T2252 T2253 det the,view
R1382 T2253 T2251 pobj view,to
R1383 T2087 T2088 advmod functionally,relevant
R1384 T2254 T2255 mark that,functions
R1385 T2255 T2253 acl functions,view
R1386 T2256 T2255 nsubj Snail,functions
R1387 T2088 T2086 acomp relevant,be
R1388 T2257 T2255 advmod likely,functions
R1389 T2258 T2255 advmod downstream,functions
R1390 T2259 T2258 prep of,downstream
R1391 T2089 T2090 mark since,affects
R1392 T2260 T2261 compound cell,fate
R1393 T2261 T2262 compound fate,specification
R1394 T2090 T2086 advcl affects,be
R1395 T2262 T2259 pobj specification,of
R1396 T2263 T2250 punct ", ",point
R1397 T2264 T2250 prep at,point
R1398 T2091 T2090 csubj altering,affects
R1399 T2265 T2266 det a,stage
R1400 T2266 T2264 pobj stage,at
R1401 T2092 T2091 dobj it,altering
R1402 T2267 T2268 advmod where,begins
R1403 T2268 T2266 relcl begins,stage
R1404 T2093 T2094 advmod in,vivo
R1405 T2269 T2270 det the,bud
R1406 T2270 T2268 nsubj bud,begins
R1407 T2094 T2091 advmod vivo,altering
R1408 T2271 T2272 aux to,exhibit
R1409 T2272 T2268 xcomp exhibit,begins
R1410 T2273 T2274 amod enhanced,proliferation
R1411 T2095 T2090 advmod correspondingly,affects
R1412 T2274 T2272 dobj proliferation,exhibit
R1413 T2275 T2274 cc and,proliferation
R1414 T2276 T2274 conj migration,proliferation
R1415 T2277 T2250 punct .,point
R1416 T2096 T2090 dobj features,affects
R227 T1019 T1020 amod Mammalian,development
R228 T1020 T1021 nsubj development,involves
R229 T1022 T1023 det the,morphogenesis
R230 T1023 T1021 dobj morphogenesis,involves
R231 T1024 T1023 prep of,morphogenesis
R232 T1025 T1026 amod complex,structures
R233 T1026 T1024 pobj structures,of
R234 T1027 T1028 advmod three,dimensional
R235 T1028 T1026 amod dimensional,structures
R236 T1029 T1028 punct -,dimensional
R237 T1030 T1023 prep from,morphogenesis
R238 T1031 T1032 advmod seemingly,uniform
R239 T1032 T1033 amod uniform,sheets
R240 T1033 T1030 pobj sheets,from
R241 T1034 T1033 cc or,sheets
R242 T1035 T1033 conj masses,sheets
R243 T1036 T1033 prep of,sheets
R244 T1037 T1036 pobj cells,of
R245 T1038 T1021 punct .,involves
R246 T1040 T1041 det A,structure
R247 T1041 T1046 nsubj structure,initiates
R248 T1042 T1041 amod simple,structure
R249 T1043 T1044 npadvmod bud,like
R250 T1044 T1041 amod like,structure
R251 T1045 T1044 punct -,like
R252 T1047 T1048 det the,formation
R253 T1048 T1046 dobj formation,initiates
R254 T1049 T1048 prep of,formation
R255 T1050 T1051 amod many,organs
R256 T1051 T1049 pobj organs,of
R257 T1052 T1051 punct ", ",organs
R258 T1053 T1051 prep including,organs
R259 T1054 T1053 pobj lungs,including
R260 T1055 T1054 punct ", ",lungs
R261 T1056 T1057 amod spinal,cord
R262 T1057 T1054 conj cord,lungs
R263 T1058 T1057 punct ", ",cord
R264 T1059 T1060 amod mammary,glands
R265 T1060 T1057 conj glands,cord
R266 T1061 T1060 punct ", ",glands
R267 T1062 T1060 cc and,glands
R268 T1063 T1064 compound hair,follicles
R269 T1064 T1060 conj follicles,glands
R270 T1065 T1066 punct [,1
R271 T1066 T1046 parataxis 1,initiates
R272 T1067 T1066 punct ],1
R273 T1068 T1046 punct .,initiates
R274 T1070 T1071 det The,cells
R275 T1071 T1076 nsubjpass cells,attached
R276 T1072 T1071 amod multipotent,cells
R277 T1073 T1071 punct ", ",cells
R278 T1074 T1071 amod adhering,cells
R279 T1075 T1071 amod epithelial,cells
R280 T1077 T1076 auxpass are,attached
R281 T1078 T1076 advmod typically,attached
R282 T1079 T1076 prep to,attached
R283 T1080 T1081 det an,lamina
R284 T1081 T1079 pobj lamina,to
R285 T1082 T1081 amod underlying,lamina
R286 T1083 T1081 amod basal,lamina
R287 T1084 T1085 dep that,polarizes
R288 T1085 T1081 relcl polarizes,lamina
R289 T1086 T1087 det the,sheet
R290 T1087 T1085 dobj sheet,polarizes
R291 T1088 T1087 amod epithelial,sheet
R292 T1089 T1085 cc and,polarizes
R293 T1090 T1085 conj separates,polarizes
R294 T1091 T1090 dobj it,separates
R295 T1092 T1090 prep from,separates
R296 T1093 T1094 amod surrounding,mesenchyme
R297 T1094 T1092 pobj mesenchyme,from
R298 T1095 T1076 punct .,attached
R299 T1097 T1098 amod Budding,morphogenesis
R300 T1098 T1099 nsubjpass morphogenesis,guided
R301 T1100 T1099 auxpass is,guided
R302 T1101 T1099 agent by,guided
R303 T1102 T1103 det a,exchange
R304 T1103 T1101 pobj exchange,by
R305 T1104 T1103 amod reciprocal,exchange
R306 T1105 T1103 prep of,exchange
R307 T1106 T1105 pobj signals,of
R308 T1107 T1103 prep between,exchange
R309 T1108 T1107 pobj epithelium,between
R310 T1109 T1108 cc and,epithelium
R311 T1110 T1108 conj mesenchyme,epithelium
R312 T1111 T1112 aux to,specify
R313 T1112 T1103 advcl specify,exchange
R314 T1113 T1114 det the,identity
R315 T1114 T1112 dobj identity,specify
R316 T1115 T1114 prep of,identity
R317 T1116 T1117 det the,organ
R318 T1117 T1115 pobj organ,of
R319 T1118 T1119 dep that,form
R320 T1119 T1117 relcl form,organ
R321 T1120 T1119 aux will,form
R322 T1121 T1112 cc and,specify
R323 T1122 T1123 aux to,govern
R324 T1123 T1112 conj govern,specify
R325 T1124 T1125 poss its,growth
R326 T1125 T1123 dobj growth,govern
R327 T1126 T1099 punct .,guided
R328 T1128 T1129 prep At,are
R329 T1130 T1131 det the,helm
R330 T1131 T1128 pobj helm,At
R331 T1132 T1131 prep of,helm
R332 T1133 T1134 det these,pathways
R333 T1134 T1132 pobj pathways,of
R334 T1135 T1136 amod molecular,communication
R335 T1136 T1134 compound communication,pathways
R336 T1137 T1129 nsubj Wnts,are
R337 T1138 T1137 punct ", ",Wnts
R338 T1139 T1140 nmod bone,proteins
R339 T1140 T1137 appos proteins,Wnts
R340 T1141 T1140 amod morphogenic,proteins
R341 T1142 T1140 punct (,proteins
R342 T1143 T1140 appos BMPs,proteins
R343 T1144 T1137 punct ),Wnts
R344 T1145 T1137 punct ", ",Wnts
R345 T1146 T1147 amod transforming,βs
R346 T1147 T1137 appos βs,Wnts
R347 T1148 T1147 compound growth,βs
R348 T1149 T1147 compound factor,βs
R349 T1150 T1147 punct (,βs
R350 T1151 T1152 compound TGF,βs
R351 T1152 T1147 appos βs,βs
R352 T1153 T1152 punct -,βs
R353 T1154 T1137 punct ),Wnts
R354 T1155 T1137 punct ", ",Wnts
R355 T1156 T1137 cc and,Wnts
R356 T1157 T1158 compound fibroblast,factors
R357 T1158 T1137 conj factors,Wnts
R358 T1159 T1158 compound growth,factors
R359 T1160 T1158 punct (,factors
R360 T1161 T1158 appos FGFs,factors
R361 T1162 T1129 punct ),are
R362 T1163 T1129 punct .,are
R363 T1165 T1166 prep Through,trigger
R364 T1167 T1165 pobj activation,Through
R365 T1168 T1167 prep of,activation
R366 T1169 T1170 compound cell,surface
R367 T1170 T1171 compound surface,receptors
R368 T1171 T1168 pobj receptors,of
R369 T1172 T1171 compound transmembrane,receptors
R370 T1173 T1166 punct ", ",trigger
R371 T1174 T1175 det these,molecules
R372 T1175 T1166 nsubj molecules,trigger
R373 T1176 T1175 amod external,molecules
R374 T1177 T1175 compound signaling,molecules
R375 T1178 T1179 amod distinct,cascades
R376 T1179 T1166 dobj cascades,trigger
R377 T1180 T1179 prep of,cascades
R378 T1181 T1182 amod intracellular,events
R379 T1182 T1180 pobj events,of
R380 T1183 T1184 dep that,culminate
R381 T1184 T1179 relcl culminate,cascades
R382 T1185 T1184 prep in,culminate
R383 T1186 T1185 pobj changes,in
R384 T1187 T1186 prep in,changes
R385 T1188 T1189 compound gene,expression
R386 T1189 T1187 pobj expression,in
R387 T1190 T1189 punct ", ",expression
R388 T1191 T1189 conj growth,expression
R389 T1192 T1191 punct ", ",growth
R390 T1193 T1191 cc and,growth
R391 T1194 T1191 conj differentiation,growth
R392 T1195 T1196 punct [,2
R393 T1196 T1166 parataxis 2,trigger
R394 T1197 T1196 punct ],2
R395 T1198 T1166 punct .,trigger
R396 T1200 T1201 advmod How,collaborates
R397 T1201 T1206 csubj collaborates,has
R398 T1202 T1203 det this,constellation
R399 T1203 T1201 nsubj constellation,collaborates
R400 T1204 T1203 prep of,constellation
R401 T1205 T1204 pobj signals,of
R402 T1207 T1201 prep in,collaborates
R403 T1208 T1207 pcomp tailoring,in
R404 T1209 T1210 det each,process
R405 T1210 T1208 dobj process,tailoring
R406 T1211 T1210 compound budding,process
R407 T1212 T1213 mark so,executes
R408 T1213 T1208 advcl executes,tailoring
R409 T1214 T1213 mark that,executes
R410 T1215 T1213 nsubj it,executes
R411 T1216 T1217 det a,program
R412 T1217 T1213 dobj program,executes
R413 T1218 T1217 amod distinct,program
R414 T1219 T1217 amod morphogenetic,program
R415 T1220 T1221 advmod yet,defined
R416 T1221 T1206 xcomp defined,has
R417 T1222 T1221 aux to,defined
R418 T1223 T1221 auxpass be,defined
R419 T1224 T1221 advmod comprehensively,defined
R420 T1225 T1206 punct .,has
R421 T1227 T1228 advmod However,appears
R422 T1229 T1228 punct ", ",appears
R423 T1230 T1231 det the,process
R424 T1231 T1228 nsubj process,appears
R425 T1232 T1233 aux to,patterned
R426 T1233 T1228 xcomp patterned,appears
R427 T1234 T1233 auxpass be,patterned
R428 T1235 T1233 prep at,patterned
R429 T1236 T1237 det the,stages
R430 T1237 T1235 pobj stages,at
R431 T1238 T1237 amod initial,stages
R432 T1239 T1237 prep of,stages
R433 T1240 T1241 compound bud,formation
R434 T1241 T1239 pobj formation,of
R435 T1242 T1228 punct ", ",appears
R436 T1243 T1244 mark since,differ
R437 T1244 T1228 advcl differ,appears
R438 T1245 T1246 det the,importance
R439 T1246 T1244 nsubj importance,differ
R440 T1247 T1246 amod relative,importance
R441 T1248 T1246 prep of,importance
R442 T1249 T1250 det these,pathways
R443 T1250 T1248 pobj pathways,of
R444 T1251 T1250 cc and,pathways
R445 T1252 T1253 poss their,effectors
R446 T1253 T1250 conj effectors,pathways
R447 T1254 T1253 amod downstream,effectors
R448 T1255 T1256 mark as,begin
R449 T1256 T1244 advcl begin,differ
R450 T1257 T1256 nsubj buds,begin
R451 T1258 T1259 aux to,develop
R452 T1259 T1256 xcomp develop,begin
R453 T1260 T1256 cc and,begin
R454 T1261 T1262 compound cell,fates
R455 T1262 T1263 nsubjpass fates,specified
R456 T1263 T1256 conj specified,begin
R457 T1264 T1263 auxpass are,specified
R458 T1265 T1228 punct .,appears
R459 T1267 T1268 det The,development
R460 T1268 T1269 nsubj development,requires
R461 T1270 T1268 prep of,development
R462 T1271 T1272 det a,bud
R463 T1272 T1270 pobj bud,of
R464 T1273 T1274 det a,number
R465 T1274 T1269 dobj number,requires
R466 T1275 T1274 prep of,number
R467 T1276 T1277 amod coordinated,changes
R468 T1277 T1275 pobj changes,of
R469 T1278 T1277 prep in,changes
R470 T1279 T1280 det the,behavior
R471 T1280 T1278 pobj behavior,in
R472 T1281 T1280 prep of,behavior
R473 T1282 T1283 det the,cells
R474 T1283 T1281 pobj cells,of
R475 T1284 T1283 amod targeted,cells
R476 T1285 T1280 prep within,behavior
R477 T1286 T1287 det an,sheet
R478 T1287 T1285 pobj sheet,within
R479 T1288 T1287 amod epithelial,sheet
R480 T1289 T1269 punct .,requires
R481 T1291 T1292 det The,process
R482 T1292 T1293 nsubjpass process,accompanied
R483 T1294 T1293 aux must,accompanied
R484 T1295 T1293 auxpass be,accompanied
R485 T1296 T1293 prep by,accompanied
R486 T1297 T1296 pobj alterations,by
R487 T1298 T1297 prep in,alterations
R488 T1299 T1300 det the,proliferation
R489 T1300 T1298 pobj proliferation,in
R490 T1301 T1300 punct ", ",proliferation
R491 T1302 T1300 conj polarity,proliferation
R492 T1303 T1302 punct ", ",polarity
R493 T1304 T1302 conj shape,polarity
R494 T1305 T1304 punct ", ",shape
R495 T1306 T1304 cc and,shape
R496 T1307 T1304 conj adhesiveness,shape
R497 T1308 T1300 prep of,proliferation
R498 T1309 T1310 amod selected,cells
R499 T1310 T1308 pobj cells,of
R500 T1311 T1296 punct ", ",by
R501 T1312 T1313 advmod as,as
R502 T1313 T1296 cc as,by
R503 T1314 T1313 advmod well,as
R504 T1315 T1296 conj by,by
R505 T1316 T1315 pobj modifications,by
R506 T1317 T1316 prep in,modifications
R507 T1318 T1319 poss their,lamina
R508 T1319 T1317 pobj lamina,in
R509 T1320 T1319 amod underlying,lamina
R510 T1321 T1319 amod basal,lamina
R511 T1322 T1293 punct .,accompanied
R512 T1324 T1325 advmod Thus,orchestrated
R513 T1326 T1325 punct ", ",orchestrated
R514 T1327 T1328 amod extracellular,crosstalk
R515 T1328 T1325 nsubjpass crosstalk,orchestrated
R516 T1329 T1330 amod epithelial,mesenchymal
R517 T1330 T1328 amod mesenchymal,crosstalk
R518 T1331 T1330 punct -,mesenchymal
R519 T1332 T1325 aux must,orchestrated
R520 T1333 T1325 auxpass be,orchestrated
R521 T1334 T1325 advmod intricately,orchestrated
R522 T1335 T1336 aux to,couple
R523 T1336 T1325 advcl couple,orchestrated
R524 T1337 T1338 det the,determination
R525 T1338 T1336 dobj determination,couple
R526 T1339 T1338 prep of,determination
R527 T1340 T1341 amod distinct,fates
R528 T1341 T1339 pobj fates,of
R529 T1342 T1341 compound cell,fates
R530 T1343 T1336 prep with,couple
R531 T1344 T1345 det the,remodeling
R532 T1345 T1343 pobj remodeling,with
R533 T1346 T1345 amod contemporaneous,remodeling
R534 T1347 T1345 prep of,remodeling
R535 T1348 T1349 det the,properties
R536 T1349 T1347 pobj properties,of
R537 T1350 T1349 amod physical,properties
R538 T1351 T1350 cc and,physical
R539 T1352 T1350 conj structural,physical
R540 T1353 T1349 prep of,properties
R541 T1354 T1355 det the,cell
R542 T1355 T1353 pobj cell,of
R543 T1356 T1325 punct .,orchestrated
R544 T1358 T1359 prep Among,offer
R545 T1360 T1361 det the,organs
R546 T1361 T1358 pobj organs,Among
R547 T1362 T1361 amod few,organs
R548 T1363 T1361 amod dispensable,organs
R549 T1364 T1359 punct ", ",offer
R550 T1365 T1366 compound hair,follicles
R551 T1366 T1359 nsubj follicles,offer
R552 T1367 T1368 det an,system
R553 T1368 T1359 dobj system,offer
R554 T1369 T1368 amod excellent,system
R555 T1370 T1368 compound model,system
R556 T1371 T1372 aux to,study
R557 T1372 T1368 advcl study,system
R558 T1373 T1374 amod epithelial,bud
R559 T1374 T1375 compound bud,formation
R560 T1375 T1372 dobj formation,study
R561 T1376 T1359 punct .,offer
R562 T1378 T1379 amod Mammalian,epithelium
R563 T1379 T1381 nsubj epithelium,begins
R564 T1380 T1379 compound skin,epithelium
R565 T1382 T1381 prep as,begins
R566 T1383 T1384 det a,sheet
R567 T1384 T1382 pobj sheet,as
R568 T1385 T1384 amod single,sheet
R569 T1386 T1384 prep of,sheet
R570 T1387 T1388 amod multipotent,cells
R571 T1388 T1386 pobj cells,of
R572 T1389 T1388 amod ectodermal,cells
R573 T1390 T1381 punct .,begins
R574 T1392 T1393 prep During,populate
R575 T1394 T1392 pobj development,During
R576 T1395 T1393 punct ", ",populate
R577 T1396 T1397 amod specialized,cells
R578 T1397 T1393 nsubj cells,populate
R579 T1398 T1397 amod mesenchymal,cells
R580 T1399 T1400 det the,skin
R581 T1400 T1393 dobj skin,populate
R582 T1401 T1393 prep in,populate
R583 T1402 T1403 det a,pattern
R584 T1403 T1401 pobj pattern,in
R585 T1404 T1405 advmod spatially,defined
R586 T1405 T1403 amod defined,pattern
R587 T1406 T1407 aux to,initiate
R588 T1407 T1393 advcl initiate,populate
R589 T1408 T1409 det the,crosstalk
R590 T1409 T1407 dobj crosstalk,initiate
R591 T1410 T1409 amod complex,crosstalk
R592 T1411 T1412 amod epithelial,mesenchymal
R593 T1412 T1409 amod mesenchymal,crosstalk
R594 T1413 T1412 punct -,mesenchymal
R595 T1414 T1415 dep that,specify
R596 T1415 T1409 relcl specify,crosstalk
R597 T1416 T1415 aux will,specify
R598 T1417 T1418 det the,bud
R599 T1418 T1415 dobj bud,specify
R600 T1419 T1420 punct [,3
R601 T1420 T1393 parataxis 3,populate
R602 T1421 T1420 punct ],3
R603 T1422 T1393 punct .,populate
R604 T1424 T1425 mark Once,committed
R605 T1425 T1426 advcl committed,instructs
R606 T1427 T1426 punct ", ",instructs
R607 T1428 T1429 det a,cluster
R608 T1429 T1426 nsubj cluster,instructs
R609 T1430 T1429 amod small,cluster
R610 T1431 T1429 prep of,cluster
R611 T1432 T1433 amod epithelial,cells
R612 T1433 T1431 pobj cells,of
R613 T1434 T1429 punct ", ",cluster
R614 T1435 T1436 det the,placode
R615 T1436 T1429 appos placode,cluster
R616 T1437 T1426 punct ", ",instructs
R617 T1438 T1439 det a,group
R618 T1439 T1440 nsubj group,condense
R619 T1440 T1426 ccomp condense,instructs
R620 T1441 T1439 prep of,group
R621 T1442 T1443 amod underlying,cells
R622 T1443 T1441 pobj cells,of
R623 T1444 T1443 amod mesenchymal,cells
R624 T1445 T1440 aux to,condense
R625 T1446 T1440 cc and,condense
R626 T1447 T1440 conj form,condense
R627 T1448 T1449 det the,papilla
R628 T1449 T1447 dobj papilla,form
R629 T1450 T1449 amod nascent,papilla
R630 T1451 T1449 amod dermal,papilla
R631 T1452 T1449 punct ", ",papilla
R632 T1453 T1454 dep which,be
R633 T1454 T1449 relcl be,papilla
R634 T1455 T1454 aux will,be
R635 T1456 T1457 det a,fixture
R636 T1457 T1454 attr fixture,be
R637 T1458 T1457 amod permanent,fixture
R638 T1459 T1457 prep of,fixture
R639 T1460 T1461 det the,follicle
R640 T1461 T1459 pobj follicle,of
R641 T1462 T1461 compound hair,follicle
R642 T1463 T1426 punct .,instructs
R643 T1465 T1466 amod Subsequent,exchanges
R644 T1466 T1467 nsubj exchanges,result
R645 T1468 T1466 prep between,exchanges
R646 T1469 T1470 det the,placode
R647 T1470 T1468 pobj placode,between
R648 T1471 T1470 cc and,placode
R649 T1472 T1473 amod nascent,papilla
R650 T1473 T1470 conj papilla,placode
R651 T1474 T1473 amod dermal,papilla
R652 T1475 T1467 prep in,result
R653 T1476 T1477 amod further,growth
R654 T1477 T1475 pobj growth,in
R655 T1478 T1477 prep of,growth
R656 T1479 T1480 det the,follicle
R657 T1480 T1478 pobj follicle,of
R658 T1481 T1477 prep into,growth
R659 T1482 T1483 det the,dermis
R660 T1483 T1481 pobj dermis,into
R661 T1484 T1483 amod underlying,dermis
R662 T1485 T1477 punct ", ",growth
R663 T1486 T1477 cc or,growth
R664 T1487 T1488 amod down,growth
R665 T1488 T1477 conj growth,growth
R666 T1489 T1488 punct -,growth
R667 T1490 T1488 punct ", ",growth
R668 T1491 T1488 cc and,growth
R669 T1492 T1493 amod eventual,differentiation
R670 T1493 T1488 conj differentiation,growth
R671 T1494 T1493 prep into,differentiation
R672 T1495 T1496 det the,layers
R673 T1496 T1494 pobj layers,into
R674 T1497 T1496 nummod six,layers
R675 T1498 T1496 amod concentric,layers
R676 T1499 T1496 prep of,layers
R677 T1500 T1501 det the,follicle
R678 T1501 T1499 pobj follicle,of
R679 T1502 T1501 amod mature,follicle
R680 T1503 T1467 punct .,result
R681 T1505 T1506 advmod Previously,delineated
R682 T1507 T1506 punct ", ",delineated
R683 T1508 T1506 nsubj we,delineated
R684 T1509 T1510 advmod how,function
R685 T1510 T1506 ccomp function,delineated
R686 T1511 T1512 nummod two,signals
R687 T1512 T1510 nsubj signals,function
R688 T1513 T1512 amod respective,signals
R689 T1514 T1512 amod epithelial,signals
R690 T1515 T1514 cc and,epithelial
R691 T1516 T1514 conj mesenchymal,epithelial
R692 T1517 T1512 punct ", ",signals
R693 T1518 T1512 appos Wnts,signals
R694 T1519 T1518 cc and,Wnts
R695 T1520 T1521 det the,factor
R696 T1521 T1518 conj factor,Wnts
R697 T1522 T1523 npadvmod BMP,inhibitory
R698 T1523 T1521 amod inhibitory,factor
R699 T1524 T1523 punct -,inhibitory
R700 T1525 T1521 appos noggin,factor
R701 T1526 T1510 punct ", ",function
R702 T1527 T1510 prep in,function
R703 T1528 T1527 pobj concert,in
R704 T1529 T1530 aux to,induce
R705 T1530 T1510 advcl induce,function
R706 T1531 T1532 amod lymphoid,factor
R707 T1532 T1534 npadvmod factor,mediated
R708 T1533 T1532 compound enhancer,factor
R709 T1534 T1551 amod mediated,transcription
R710 T1535 T1532 punct -,factor
R711 T1536 T1532 nummod 1,factor
R712 T1537 T1532 punct /,factor
R713 T1538 T1539 compound β,catenin
R714 T1539 T1532 appos catenin,factor
R715 T1540 T1539 punct -,catenin
R716 T1541 T1532 punct (,factor
R717 T1542 T1532 appos LEF,factor
R718 T1543 T1542 punct -,LEF
R719 T1544 T1542 nummod 1,LEF
R720 T1545 T1542 punct /,LEF
R721 T1546 T1547 compound β,catenin
R722 T1547 T1542 appos catenin,LEF
R723 T1548 T1547 punct -,catenin
R724 T1549 T1534 punct ),mediated
R725 T1550 T1534 punct -,mediated
R726 T1551 T1530 dobj transcription,induce
R727 T1552 T1551 compound gene,transcription
R728 T1553 T1530 prep within,induce
R729 T1554 T1555 det the,placode
R730 T1555 T1553 pobj placode,within
R731 T1556 T1555 compound follicle,placode
R732 T1557 T1558 punct [,4
R733 T1558 T1506 parataxis 4,delineated
R734 T1559 T1558 punct ],4
R735 T1560 T1506 punct .,delineated
R736 T1562 T1563 det The,changes
R737 T1563 T1565 nsubj changes,include
R738 T1564 T1563 amod downstream,changes
R739 T1566 T1563 acl elicited,changes
R740 T1567 T1566 prep through,elicited
R741 T1568 T1567 pobj convergence,through
R742 T1569 T1568 prep of,convergence
R743 T1675 T1677 compound cell,contact
R744 T1676 T1675 punct -,cell
R745 T1677 T1673 pobj contact,of
R746 T1678 T1671 punct ", ",recruit
R747 T1679 T1671 advmod however,recruit
R748 T1570 T1571 det these,pathways
R749 T1680 T1671 punct ", ",recruit
R750 T1571 T1569 pobj pathways,of
R751 T1681 T1682 nmod E,cadherin
R752 T1572 T1571 nummod two,pathways
R753 T1573 T1571 amod early,pathways
R754 T1682 T1684 nmod cadherin,complexes
R755 T1574 T1571 compound signaling,pathways
R756 T1575 T1576 amod down,regulation
R757 T1683 T1682 punct -,cadherin
R758 T1576 T1565 dobj regulation,include
R759 T1577 T1576 punct -,regulation
R760 T1578 T1576 prep of,regulation
R761 T1684 T1671 nsubj complexes,recruit
R762 T1579 T1580 det the,gene
R763 T1580 T1578 pobj gene,of
R764 T1685 T1682 punct -,cadherin
R765 T1581 T1580 acl encoding,gene
R766 T1582 T1583 compound E,cadherin
R767 T1583 T1581 dobj cadherin,encoding
R768 T1686 T1687 compound β,catenin
R769 T1584 T1583 punct -,cadherin
R770 T1585 T1583 punct ", ",cadherin
R771 T1586 T1587 det the,cadherin
R772 T1687 T1682 appos catenin,cadherin
R773 T1587 T1583 appos cadherin,cadherin
R774 T1588 T1587 amod prototypical,cadherin
R775 T1688 T1687 punct -,catenin
R776 T1589 T1587 amod epithelial,cadherin
R777 T1590 T1591 dep that,forms
R778 T1591 T1587 relcl forms,cadherin
R779 T1689 T1690 compound α,catenin
R780 T1592 T1593 det the,core
R781 T1593 T1591 dobj core,forms
R782 T1690 T1671 dobj catenin,recruit
R783 T1594 T1593 amod transmembrane,core
R784 T1595 T1593 prep of,core
R785 T1596 T1597 amod intercellular,junctions
R786 T1691 T1690 punct -,catenin
R787 T1597 T1595 pobj junctions,of
R788 T1598 T1597 compound adherens,junctions
R789 T1599 T1597 punct (,junctions
R790 T1692 T1690 punct ", ",catenin
R791 T1600 T1597 appos AJs,junctions
R792 T1601 T1565 punct ),include
R793 T1602 T1603 punct [,5
R794 T1603 T1565 parataxis 5,include
R795 T1604 T1603 punct ],5
R796 T1693 T1694 dep which,coordinates
R797 T1605 T1565 punct .,include
R798 T1607 T1608 nsubj We,showed
R799 T1694 T1690 relcl coordinates,catenin
R800 T1609 T1608 advmod subsequently,showed
R801 T1695 T1694 prep in,coordinates
R802 T1610 T1611 mark that,blocked
R803 T1696 T1695 pobj turn,in
R804 T1611 T1608 ccomp blocked,showed
R805 T1697 T1698 det the,dynamics
R806 T1612 T1613 advmod when,elevated
R807 T1613 T1611 advcl elevated,blocked
R808 T1698 T1694 dobj dynamics,coordinates
R809 T1614 T1615 compound E,cadherin
R810 T1615 T1613 nsubjpass cadherin,elevated
R811 T1616 T1615 punct -,cadherin
R812 T1699 T1698 amod associated,dynamics
R813 T1617 T1613 auxpass is,elevated
R814 T1618 T1613 advmod transgenically,elevated
R815 T1700 T1698 compound actin,dynamics
R816 T1619 T1613 prep in,elevated
R817 T1620 T1621 compound mouse,skin
R818 T1621 T1619 pobj skin,in
R819 T1701 T1698 compound polymerization,dynamics
R820 T1622 T1611 punct ", ",blocked
R821 T1623 T1624 compound hair,follicle
R822 T1624 T1625 compound follicle,morphogenesis
R823 T1702 T1698 amod necessary,dynamics
R824 T1625 T1611 nsubjpass morphogenesis,blocked
R825 T1626 T1611 auxpass is,blocked
R826 T1627 T1611 punct ", ",blocked
R827 T1703 T1704 aux to,stabilize
R828 T1628 T1611 advcl suggesting,blocked
R829 T1629 T1630 mark that,is
R830 T1630 T1628 ccomp is,suggesting
R831 T1704 T1702 xcomp stabilize,necessary
R832 T1631 T1632 nmod E,cadherin
R833 T1632 T1634 nmod cadherin,regulation
R834 T1705 T1706 amod nascent,AJs
R835 T1633 T1632 punct -,cadherin
R836 T1634 T1630 nsubj regulation,is
R837 T1635 T1634 amod down,regulation
R838 T1706 T1704 dobj AJs,stabilize
R839 T1636 T1634 punct -,regulation
R840 T1637 T1638 det a,event
R841 T1638 T1630 attr event,is
R842 T1639 T1638 amod critical,event
R843 T1640 T1638 prep in,event
R844 T1707 T1704 cc and,stabilize
R845 T1708 T1704 conj integrate,stabilize
R846 T1641 T1640 pcomp governing,in
R847 T1709 T1710 det the,cytoskeleton
R848 T1642 T1643 det the,dynamics
R849 T1643 T1641 dobj dynamics,governing
R850 T1644 T1643 compound adhesion,dynamics
R851 T1710 T1708 dobj cytoskeleton,integrate
R852 T1645 T1643 amod necessary,dynamics
R853 T1646 T1645 prep for,necessary
R854 T1647 T1648 compound budding,morphogenesis
R855 T1711 T1708 prep across,integrate
R856 T1648 T1646 pobj morphogenesis,for
R857 T1649 T1650 punct [,4
R858 T1712 T1713 det an,sheet
R859 T1650 T1608 parataxis 4,showed
R860 T1651 T1650 punct ],4
R861 T1652 T1608 punct .,showed
R862 T1713 T1711 pobj sheet,across
R863 T1654 T1655 prep Like,binds
R864 T1714 T1713 amod epithelial,sheet
R865 T1656 T1654 pobj LEF,Like
R866 T1657 T1656 punct -,LEF
R867 T1715 T1716 punct [,8
R868 T1658 T1656 nummod 1,LEF
R869 T1659 T1655 punct ", ",binds
R870 T1660 T1661 compound E,cadherin
R871 T1661 T1655 nsubj cadherin,binds
R872 T1716 T1694 parataxis 8,coordinates
R873 T1662 T1661 punct -,cadherin
R874 T1663 T1655 advmod also,binds
R875 T1717 T1716 nummod 6,8
R876 T1664 T1655 prep to,binds
R877 T1665 T1666 compound β,catenin
R878 T1666 T1664 pobj catenin,to
R879 T1718 T1716 punct ",",8
R880 T1667 T1666 punct -,catenin
R881 T1668 T1655 punct .,binds
R882 T1719 T1716 nummod 7,8
R883 T1670 T1671 prep At,recruit
R884 T1720 T1716 punct ",",8
R885 T1672 T1670 pobj sites,At
R886 T1673 T1672 prep of,sites
R887 T1674 T1675 compound cell,cell
R888 T1721 T1716 punct ],8
R889 T1722 T1671 punct .,recruit
R890 T1724 T1725 compound α,Catenin
R891 T1725 T1727 nsubj Catenin,binds
R892 T1726 T1725 punct -,Catenin
R893 T1780 T1779 compound protein,kinase
R894 T1781 T1779 punct (,kinase
R895 T1782 T1779 appos MAPK,kinase
R896 T1728 T1727 advmod also,binds
R897 T1783 T1773 punct ),pathway
R898 T1784 T1785 punct [,10
R899 T1729 T1727 prep to,binds
R900 T1785 T1727 parataxis 10,binds
R901 T1786 T1785 nummod 9,10
R902 T1730 T1731 det the,protein
R903 T1787 T1785 punct ",",10
R904 T1788 T1785 punct ],10
R905 T1731 T1729 pobj protein,to
R906 T1789 T1727 punct .,binds
R907 T1732 T1731 nmod class,protein
R908 T1791 T1792 prep Through,appear
R909 T1793 T1794 det these,links
R910 T1733 T1732 nummod III,class
R911 T1794 T1791 pobj links,Through
R912 T1795 T1792 punct ", ",appear
R913 T1734 T1731 nmod Lin,protein
R914 T1796 T1792 nsubj AJs,appear
R915 T1797 T1792 oprd able,appear
R916 T1798 T1799 aux to,couple
R917 T1735 T1734 punct -,Lin
R918 T1799 T1797 xcomp couple,able
R919 T1800 T1799 dobj adhesion,couple
R920 T1736 T1734 nummod 1,Lin
R921 T1801 T1799 prep with,couple
R922 T1802 T1803 amod cytoskeletal,dynamics
R923 T1803 T1801 pobj dynamics,with
R924 T1737 T1734 punct ", ",Lin
R925 T1804 T1805 advmod as,as
R926 T1805 T1801 cc as,with
R927 T1806 T1805 advmod well,as
R928 T1738 T1734 appos Isl,Lin
R929 T1807 T1801 conj with,with
R930 T1808 T1809 amod nuclear,signaling
R931 T1739 T1738 punct -,Isl
R932 T1809 T1807 pobj signaling,with
R933 T1810 T1808 cc and,nuclear
R934 T1811 T1808 conj cytoplasmic,nuclear
R935 T1740 T1738 nummod 1,Isl
R936 T1812 T1792 punct .,appear
R937 T1814 T1815 nsubj This,provides
R938 T1741 T1734 punct ", ",Lin
R939 T1816 T1817 det a,framework
R940 T1742 T1734 appos Mec,Lin
R941 T1817 T1815 dobj framework,provides
R942 T1818 T1817 prep for,framework
R943 T1819 T1818 pcomp conceptualizing,for
R944 T1820 T1821 advmod why,appear
R945 T1821 T1819 ccomp appear,conceptualizing
R946 T1822 T1823 compound E,cadherin
R947 T1743 T1742 punct -,Mec
R948 T1823 T1825 compound cadherin,levels
R949 T1824 T1823 punct -,cadherin
R950 T1825 T1821 nsubj levels,appear
R951 T1826 T1827 aux to,impact
R952 T1744 T1742 nummod 3,Mec
R953 T1827 T1821 xcomp impact,appear
R954 T1828 T1827 prep upon,impact
R955 T1745 T1734 punct (,Lin
R956 T1829 T1830 det a,plethora
R957 T1830 T1828 pobj plethora,upon
R958 T1831 T1830 prep of,plethora
R959 T1746 T1734 appos LIM,Lin
R960 T1832 T1833 amod developmental,processes
R961 T1833 T1831 pobj processes,of
R962 T1834 T1835 punct (,reviewed
R963 T1747 T1731 punct ),protein
R964 T1835 T1815 parataxis reviewed,provides
R965 T1836 T1835 prep in,reviewed
R966 T1837 T1836 punct [,in
R967 T1748 T1731 appos Ajuba,protein
R968 T1838 T1836 pobj 11,in
R969 T1839 T1835 punct ],reviewed
R970 T1840 T1835 punct ),reviewed
R971 T1749 T1731 punct (,protein
R972 T1841 T1815 punct .,provides
R973 T1750 T1751 det a,member
R974 T1843 T1844 mark As,probed
R975 T1844 T1846 advcl probed,intrigued
R976 T1845 T1844 nsubj we,probed
R977 T1751 T1731 appos member,protein
R978 T1847 T1848 advmod more,deeply
R979 T1848 T1844 advmod deeply,probed
R980 T1752 T1751 prep of,member
R981 T1849 T1844 prep into,probed
R982 T1850 T1851 det the,mechanisms
R983 T1851 T1849 pobj mechanisms,into
R984 T1753 T1754 det the,family
R985 T1852 T1851 amod underlying,mechanisms
R986 T1853 T1851 acl governing,mechanisms
R987 T1854 T1855 compound E,cadherin
R988 T1754 T1752 pobj family,of
R989 T1855 T1857 compound cadherin,promoter
R990 T1856 T1855 punct -,cadherin
R991 T1857 T1858 compound promoter,activity
R992 T1755 T1754 compound zyxin,family
R993 T1858 T1853 dobj activity,governing
R994 T1859 T1846 punct ", ",intrigued
R995 T1756 T1754 prep of,family
R996 T1860 T1846 nsubjpass we,intrigued
R997 T1861 T1846 auxpass were,intrigued
R998 T1862 T1846 agent by,intrigued
R999 T1863 T1864 det the,proximity