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PMC:529315 / 2564-18283 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2324 9-13 NN denotes TrkC
T2326 13-14 HYPH denotes -
T2325 14-22 JJ denotes Positive
T2328 23-26 NN denotes DRG
T2327 27-34 NNS denotes Neurons
T2330 35-38 VBP denotes Are
T2329 39-46 VBN denotes Rescued
T2331 47-49 IN denotes in
T2332 50-53 NN denotes Bax
T2334 53-54 HYPH denotes /
T2335 54-56 NN denotes NT
T2336 56-57 HYPH denotes -
T2337 57-58 CD denotes 3
T2338 59-65 JJ denotes Double
T2333 66-74 NN denotes Knockout
T2339 75-79 NNS denotes Mice
T2340 79-196 sentence denotes Mice lacking proapoptotic protein Bax allow for distinguishing survival effects of neurotrophins from other effects.
T2341 80-84 NNS denotes Mice
T2343 85-92 VBG denotes lacking
T2344 93-105 JJ denotes proapoptotic
T2346 106-113 NN denotes protein
T2345 114-117 NN denotes Bax
T2342 118-123 VBP denotes allow
T2347 124-127 IN denotes for
T2348 128-142 VBG denotes distinguishing
T2349 143-151 NN denotes survival
T2350 152-159 NNS denotes effects
T2351 160-162 IN denotes of
T2352 163-176 NNS denotes neurotrophins
T2353 177-181 IN denotes from
T2354 182-187 JJ denotes other
T2355 188-195 NNS denotes effects
T2356 195-196 . denotes .
T2357 196-360 sentence denotes Bax-deficient sensory neurons no longer require neurotrophins for survival (White et al. 1998; Patel et al. 2000), thus they can be used to examine axonal effects.
T2358 197-200 NN denotes Bax
T2360 200-201 HYPH denotes -
T2359 201-210 JJ denotes deficient
T2362 211-218 JJ denotes sensory
T2361 219-226 NNS denotes neurons
T2364 227-229 RB denotes no
T2365 230-236 RB denotes longer
T2363 237-244 VBP denotes require
T2367 245-258 NNS denotes neurotrophins
T2368 259-262 IN denotes for
T2369 263-271 NN denotes survival
T2370 272-273 -LRB- denotes (
T2371 273-278 NNP denotes White
T2372 279-281 FW denotes et
T2373 282-285 FW denotes al.
T2374 286-290 CD denotes 1998
T2375 290-291 : denotes ;
T2376 292-297 NNP denotes Patel
T2377 298-300 FW denotes et
T2378 301-304 FW denotes al.
T2379 305-309 CD denotes 2000
T2380 309-310 -RRB- denotes )
T2381 310-312 , denotes ,
T2382 312-316 RB denotes thus
T2383 317-321 PRP denotes they
T2384 322-325 MD denotes can
T2385 326-328 VB denotes be
T2366 329-333 VBN denotes used
T2386 334-336 TO denotes to
T2387 337-344 VB denotes examine
T2388 345-351 JJ denotes axonal
T2389 352-359 NNS denotes effects
T2390 359-360 . denotes .
T2391 360-519 sentence denotes We bred NT-3 heterozygote and Bax knockout (KO) mice to obtain mice with double KO of both NT-3 and Bax genes, and examined proprioceptive axonal projections.
T2392 361-363 PRP denotes We
T2393 364-368 VBD denotes bred
T2394 369-371 NN denotes NT
T2396 371-372 HYPH denotes -
T2397 372-373 CD denotes 3
T2395 374-386 NN denotes heterozygote
T2398 387-390 CC denotes and
T2399 391-394 NN denotes Bax
T2400 395-403 NN denotes knockout
T2402 404-405 -LRB- denotes (
T2403 405-407 NN denotes KO
T2404 407-408 -RRB- denotes )
T2401 409-413 NNS denotes mice
T2405 414-416 TO denotes to
T2406 417-423 VB denotes obtain
T2407 424-428 NNS denotes mice
T2408 429-433 IN denotes with
T2409 434-440 JJ denotes double
T2410 441-443 NN denotes KO
T2411 444-446 IN denotes of
T2412 447-451 CC denotes both
T2413 452-454 NN denotes NT
T2415 454-455 HYPH denotes -
T2416 455-456 CD denotes 3
T2417 457-460 CC denotes and
T2418 461-464 NN denotes Bax
T2414 465-470 NNS denotes genes
T2419 470-472 , denotes ,
T2420 472-475 CC denotes and
T2421 476-484 VBN denotes examined
T2422 485-499 JJ denotes proprioceptive
T2424 500-506 JJ denotes axonal
T2423 507-518 NNS denotes projections
T2425 518-519 . denotes .
T2426 519-598 sentence denotes All NT-3 and double KOs died within 48 h after birth (Tessarollo et al. 1994).
T2427 520-523 DT denotes All
T2429 524-526 NN denotes NT
T2430 526-527 HYPH denotes -
T2431 527-528 CD denotes 3
T2432 529-532 CC denotes and
T2433 533-539 JJ denotes double
T2428 540-543 NNS denotes KOs
T2434 544-548 VBD denotes died
T2435 549-555 IN denotes within
T2436 556-558 CD denotes 48
T2437 559-560 NN denotes h
T2438 561-566 IN denotes after
T2439 567-572 NN denotes birth
T2440 573-574 -LRB- denotes (
T2441 574-584 NNP denotes Tessarollo
T2442 585-587 FW denotes et
T2443 588-591 FW denotes al.
T2444 592-596 CD denotes 1994
T2445 596-597 -RRB- denotes )
T2446 597-598 . denotes .
T2447 598-726 sentence denotes We performed TrkA/TrkC double immunohistochemistry (Huang et al. 1999), enabling detection of both proteins in the same sample.
T2448 599-601 PRP denotes We
T2449 602-611 VBD denotes performed
T2450 612-616 NN denotes TrkA
T2452 616-617 HYPH denotes /
T2451 617-621 NN denotes TrkC
T2454 622-628 JJ denotes double
T2453 629-649 NN denotes immunohistochemistry
T2455 650-651 -LRB- denotes (
T2456 651-656 NNP denotes Huang
T2457 657-659 FW denotes et
T2458 660-663 FW denotes al.
T2459 664-668 CD denotes 1999
T2460 668-669 -RRB- denotes )
T2461 669-671 , denotes ,
T2462 671-679 VBG denotes enabling
T2463 680-689 NN denotes detection
T2464 690-692 IN denotes of
T2465 693-697 DT denotes both
T2466 698-706 NN denotes proteins
T2467 707-709 IN denotes in
T2468 710-713 DT denotes the
T2470 714-718 JJ denotes same
T2469 719-725 NN denotes sample
T2471 725-726 . denotes .
T2472 726-830 sentence denotes TrkC-positive cells (Figure 1A) and fibers (Figure 1E) were absent in NT-3 KOs at embryonic day (E) 15.
T2473 727-731 NN denotes TrkC
T2475 731-732 HYPH denotes -
T2474 732-740 JJ denotes positive
T2476 741-746 NNS denotes cells
T2478 747-748 -LRB- denotes (
T2480 748-754 NN denotes Figure
T2479 755-757 NN denotes 1A
T2481 757-758 -RRB- denotes )
T2482 759-762 CC denotes and
T2483 763-769 NNS denotes fibers
T2484 770-771 -LRB- denotes (
T2486 771-777 NN denotes Figure
T2485 778-780 NN denotes 1E
T2487 780-781 -RRB- denotes )
T2477 782-786 VBD denotes were
T2488 787-793 JJ denotes absent
T2489 794-796 IN denotes in
T2490 797-799 NN denotes NT
T2492 799-800 HYPH denotes -
T2493 800-801 CD denotes 3
T2491 802-805 NNS denotes KOs
T2494 806-808 IN denotes at
T2495 809-818 JJ denotes embryonic
T2496 819-822 NN denotes day
T2497 823-824 -LRB- denotes (
T2498 824-825 NN denotes E
T2499 825-826 -RRB- denotes )
T2500 827-829 CD denotes 15
T2501 829-830 . denotes .
T2502 830-960 sentence denotes Two subsets of DRG cells expressing either TrkA or TrkC were detected in double KOs, similar to wild-type (WT) or Bax KO animals.
T2503 831-834 CD denotes Two
T2504 835-842 NNS denotes subsets
T2506 843-845 IN denotes of
T2507 846-849 NN denotes DRG
T2508 850-855 NNS denotes cells
T2509 856-866 VBG denotes expressing
T2510 867-873 CC denotes either
T2511 874-878 NN denotes TrkA
T2512 879-881 CC denotes or
T2513 882-886 NN denotes TrkC
T2514 887-891 VBD denotes were
T2505 892-900 VBN denotes detected
T2515 901-903 IN denotes in
T2516 904-910 JJ denotes double
T2517 911-914 NNS denotes KOs
T2518 914-916 , denotes ,
T2519 916-923 JJ denotes similar
T2520 924-926 IN denotes to
T2521 927-931 JJ denotes wild
T2523 931-932 HYPH denotes -
T2522 932-936 NN denotes type
T2525 937-938 -LRB- denotes (
T2526 938-940 NN denotes WT
T2527 940-941 -RRB- denotes )
T2528 942-944 CC denotes or
T2529 945-948 NN denotes Bax
T2530 949-951 NN denotes KO
T2524 952-959 NNS denotes animals
T2531 959-960 . denotes .
T2532 960-1167 sentence denotes Surprisingly, at postnatal day (P) 0, a few cells expressed TrkC even in NT-3 KO animals in the Bax +/+ genetic background, and some cells co-expressed TrkA and TrkC, regardless of the genotype (Figure 1B).
T2533 961-973 RB denotes Surprisingly
T2535 973-975 , denotes ,
T2536 975-977 IN denotes at
T2537 978-987 JJ denotes postnatal
T2538 988-991 NN denotes day
T2539 992-993 -LRB- denotes (
T2540 993-994 NN denotes P
T2541 994-995 -RRB- denotes )
T2542 996-997 CD denotes 0
T2543 997-999 , denotes ,
T2544 999-1000 DT denotes a
T2546 1001-1004 JJ denotes few
T2545 1005-1010 NNS denotes cells
T2534 1011-1020 VBD denotes expressed
T2547 1021-1025 NN denotes TrkC
T2548 1026-1030 RB denotes even
T2549 1031-1033 IN denotes in
T2550 1034-1036 NN denotes NT
T2552 1036-1037 HYPH denotes -
T2553 1037-1038 CD denotes 3
T2551 1039-1041 NN denotes KO
T2554 1042-1049 NNS denotes animals
T2555 1050-1052 IN denotes in
T2556 1053-1056 DT denotes the
T2558 1057-1060 NN denotes Bax
T2559 1061-1062 SYM denotes +
T2560 1062-1063 HYPH denotes /
T2561 1063-1064 SYM denotes +
T2562 1065-1072 JJ denotes genetic
T2557 1073-1083 NN denotes background
T2563 1083-1085 , denotes ,
T2564 1085-1088 CC denotes and
T2565 1089-1093 DT denotes some
T2566 1094-1099 NNS denotes cells
T2567 1100-1112 VBD denotes co-expressed
T2568 1113-1117 NN denotes TrkA
T2569 1118-1121 CC denotes and
T2570 1122-1126 NN denotes TrkC
T2571 1126-1128 , denotes ,
T2572 1128-1138 RB denotes regardless
T2573 1139-1141 IN denotes of
T2574 1142-1145 DT denotes the
T2575 1146-1154 NN denotes genotype
T2576 1155-1156 -LRB- denotes (
T2578 1156-1162 NN denotes Figure
T2577 1163-1165 NN denotes 1B
T2579 1165-1166 -RRB- denotes )
T2580 1166-1167 . denotes .
T2581 1167-1321 sentence denotes In order to quantify our results, we analyzed the ratio of TrkA and TrkC immunopositive cells from four different DRGs of animals of different genotypes.
T2582 1168-1170 IN denotes In
T2584 1171-1176 NN denotes order
T2585 1177-1179 TO denotes to
T2586 1180-1188 VB denotes quantify
T2587 1189-1192 PRP$ denotes our
T2588 1193-1200 NNS denotes results
T2589 1200-1202 , denotes ,
T2590 1202-1204 PRP denotes we
T2583 1205-1213 VBD denotes analyzed
T2591 1214-1217 DT denotes the
T2592 1218-1223 NN denotes ratio
T2593 1224-1226 IN denotes of
T2594 1227-1231 NN denotes TrkA
T2596 1232-1235 CC denotes and
T2597 1236-1240 NN denotes TrkC
T2595 1241-1255 JJ denotes immunopositive
T2598 1256-1261 NNS denotes cells
T2599 1262-1266 IN denotes from
T2600 1267-1271 CD denotes four
T2602 1272-1281 JJ denotes different
T2601 1282-1286 NNS denotes DRGs
T2603 1287-1289 IN denotes of
T2604 1290-1297 NNS denotes animals
T2605 1298-1300 IN denotes of
T2606 1301-1310 JJ denotes different
T2607 1311-1320 NNS denotes genotypes
T2608 1320-1321 . denotes .
T2609 1321-1477 sentence denotes At all ages studied, Bax/NT-3 double null DRGs had TrkA/TrkC ratios similar to those of Bax null DRGs, and higher than those of NT-3 null DRGs (Figure 1D).
T2610 1322-1324 IN denotes At
T2612 1325-1328 DT denotes all
T2613 1329-1333 NNS denotes ages
T2614 1334-1341 VBN denotes studied
T2615 1341-1343 , denotes ,
T2616 1343-1346 NN denotes Bax
T2618 1346-1347 HYPH denotes /
T2619 1347-1349 NN denotes NT
T2620 1349-1350 HYPH denotes -
T2621 1350-1351 CD denotes 3
T2622 1352-1358 JJ denotes double
T2617 1359-1363 JJ denotes null
T2623 1364-1368 NNS denotes DRGs
T2611 1369-1372 VBD denotes had
T2624 1373-1377 NN denotes TrkA
T2626 1377-1378 HYPH denotes /
T2625 1378-1382 NN denotes TrkC
T2627 1383-1389 NNS denotes ratios
T2628 1390-1397 JJ denotes similar
T2629 1398-1400 IN denotes to
T2630 1401-1406 DT denotes those
T2631 1407-1409 IN denotes of
T2632 1410-1413 NN denotes Bax
T2633 1414-1418 JJ denotes null
T2634 1419-1423 NNS denotes DRGs
T2635 1423-1425 , denotes ,
T2636 1425-1428 CC denotes and
T2637 1429-1435 JJR denotes higher
T2638 1436-1440 IN denotes than
T2639 1441-1446 DT denotes those
T2640 1447-1449 IN denotes of
T2641 1450-1452 NN denotes NT
T2643 1452-1453 HYPH denotes -
T2644 1453-1454 CD denotes 3
T2642 1455-1459 JJ denotes null
T2645 1460-1464 NNS denotes DRGs
T2646 1465-1466 -LRB- denotes (
T2648 1466-1472 NN denotes Figure
T2647 1473-1475 NN denotes 1D
T2649 1475-1476 -RRB- denotes )
T2650 1476-1477 . denotes .
T2651 1477-1675 sentence denotes TrkC-positive neurons rescued by Bax deletion, however, failed to differentiate properly, as evidenced by the lack of expression of the proprioceptive molecular marker Parvalbumin (PV) (Figure 1C).
T2652 1478-1482 NN denotes TrkC
T2654 1482-1483 HYPH denotes -
T2653 1483-1491 JJ denotes positive
T2655 1492-1499 NNS denotes neurons
T2657 1500-1507 VBN denotes rescued
T2658 1508-1510 IN denotes by
T2659 1511-1514 NN denotes Bax
T2660 1515-1523 NN denotes deletion
T2661 1523-1525 , denotes ,
T2662 1525-1532 RB denotes however
T2663 1532-1534 , denotes ,
T2656 1534-1540 VBD denotes failed
T2664 1541-1543 TO denotes to
T2665 1544-1557 VB denotes differentiate
T2666 1558-1566 RB denotes properly
T2667 1566-1568 , denotes ,
T2668 1568-1570 IN denotes as
T2669 1571-1580 VBN denotes evidenced
T2670 1581-1583 IN denotes by
T2671 1584-1587 DT denotes the
T2672 1588-1592 NN denotes lack
T2673 1593-1595 IN denotes of
T2674 1596-1606 NN denotes expression
T2675 1607-1609 IN denotes of
T2676 1610-1613 DT denotes the
T2678 1614-1628 JJ denotes proprioceptive
T2679 1629-1638 JJ denotes molecular
T2677 1639-1645 NN denotes marker
T2680 1646-1657 NN denotes Parvalbumin
T2681 1658-1659 -LRB- denotes (
T2682 1659-1661 NN denotes PV
T2683 1661-1662 -RRB- denotes )
T2684 1663-1664 -LRB- denotes (
T2686 1664-1670 NN denotes Figure
T2685 1671-1673 NN denotes 1C
T2687 1673-1674 -RRB- denotes )
T2688 1674-1675 . denotes .
T3969 2491-2493 NN denotes NT
T3971 2493-2494 HYPH denotes -
T3972 2494-2495 CD denotes 3
T3970 2496-2498 VBZ denotes Is
T3973 2499-2508 JJ denotes Necessary
T3974 2509-2512 IN denotes for
T3975 2513-2519 JJ denotes Proper
T3976 2520-2531 NN denotes Innervation
T3977 2532-2534 IN denotes of
T3978 2535-2540 JJ denotes Motor
T3979 2541-2548 NNS denotes Neurons
T3980 2548-2631 sentence denotes TrkA/TrkC-positive fibers in the spinal cord could be detected at E15 (Figure 1E).
T3981 2549-2553 NN denotes TrkA
T3983 2553-2554 HYPH denotes /
T3982 2554-2558 NN denotes TrkC
T3985 2558-2559 HYPH denotes -
T3984 2559-2567 JJ denotes positive
T3986 2568-2574 NNS denotes fibers
T3988 2575-2577 IN denotes in
T3989 2578-2581 DT denotes the
T3991 2582-2588 JJ denotes spinal
T3990 2589-2593 NN denotes cord
T3992 2594-2599 MD denotes could
T3993 2600-2602 VB denotes be
T3987 2603-2611 VBN denotes detected
T3994 2612-2614 IN denotes at
T3995 2615-2618 NN denotes E15
T3996 2619-2620 -LRB- denotes (
T3998 2620-2626 NN denotes Figure
T3997 2627-2629 NN denotes 1E
T3999 2629-2630 -RRB- denotes )
T4000 2630-2631 . denotes .
T4001 2631-2867 sentence denotes TrkA-positive fibers were restricted to and terminated in the dorsolateral spinal cord, whereas TrkC-positive fibers entered the cord dorsomedially, and descended into the ventral horns in WT (Ozaki and Snider 1997) and Bax KO embryos.
T4002 2632-2636 NN denotes TrkA
T4004 2636-2637 HYPH denotes -
T4003 2637-2645 JJ denotes positive
T4005 2646-2652 NNS denotes fibers
T4007 2653-2657 VBD denotes were
T4006 2658-2668 VBN denotes restricted
T4008 2669-2671 IN denotes to
T4009 2672-2675 CC denotes and
T4010 2676-2686 VBN denotes terminated
T4011 2687-2689 IN denotes in
T4012 2690-2693 DT denotes the
T4014 2694-2706 JJ denotes dorsolateral
T4015 2707-2713 JJ denotes spinal
T4013 2714-2718 NN denotes cord
T4016 2718-2720 , denotes ,
T4017 2720-2727 IN denotes whereas
T4019 2728-2732 NN denotes TrkC
T4021 2732-2733 HYPH denotes -
T4020 2733-2741 JJ denotes positive
T4022 2742-2748 NNS denotes fibers
T4018 2749-2756 VBD denotes entered
T4023 2757-2760 DT denotes the
T4024 2761-2765 NN denotes cord
T4025 2766-2779 RB denotes dorsomedially
T4026 2779-2781 , denotes ,
T4027 2781-2784 CC denotes and
T4028 2785-2794 VBD denotes descended
T4029 2795-2799 IN denotes into
T4030 2800-2803 DT denotes the
T4032 2804-2811 JJ denotes ventral
T4031 2812-2817 NNS denotes horns
T4033 2818-2820 IN denotes in
T4034 2821-2823 NN denotes WT
T4036 2824-2825 -LRB- denotes (
T4037 2825-2830 NNP denotes Ozaki
T4038 2831-2834 CC denotes and
T4039 2835-2841 NNP denotes Snider
T4040 2842-2846 CD denotes 1997
T4041 2846-2847 -RRB- denotes )
T4042 2848-2851 CC denotes and
T4043 2852-2855 NN denotes Bax
T4044 2856-2858 NN denotes KO
T4035 2859-2866 NNS denotes embryos
T4045 2866-2867 . denotes .
T4046 2867-2985 sentence denotes There was no detectable TrkC expression in NT-3 KO spinal cord, indicating complete absence of proprioceptive fibers.
T4047 2868-2873 EX denotes There
T4048 2874-2877 VBD denotes was
T4049 2878-2880 DT denotes no
T4051 2881-2891 JJ denotes detectable
T4052 2892-2896 NN denotes TrkC
T4050 2897-2907 NN denotes expression
T4053 2908-2910 IN denotes in
T4054 2911-2913 NN denotes NT
T4056 2913-2914 HYPH denotes -
T4057 2914-2915 CD denotes 3
T4055 2916-2918 NN denotes KO
T4059 2919-2925 JJ denotes spinal
T4058 2926-2930 NN denotes cord
T4060 2930-2932 , denotes ,
T4061 2932-2942 VBG denotes indicating
T4062 2943-2951 JJ denotes complete
T4063 2952-2959 NN denotes absence
T4064 2960-2962 IN denotes of
T4065 2963-2977 JJ denotes proprioceptive
T4066 2978-2984 NNS denotes fibers
T4067 2984-2985 . denotes .
T4068 2985-3142 sentence denotes In double KO spinal cord, TrkC-positive fibers entered the dorsal spinal cord and descended medially in a manner similar to that seen in WT or Bax KO cases.
T4069 2986-2988 IN denotes In
T4071 2989-2995 JJ denotes double
T4072 2996-2998 NN denotes KO
T4074 2999-3005 JJ denotes spinal
T4073 3006-3010 NN denotes cord
T4075 3010-3012 , denotes ,
T4076 3012-3016 NN denotes TrkC
T4078 3016-3017 HYPH denotes -
T4077 3017-3025 JJ denotes positive
T4079 3026-3032 NNS denotes fibers
T4070 3033-3040 VBD denotes entered
T4080 3041-3044 DT denotes the
T4082 3045-3051 JJ denotes dorsal
T4083 3052-3058 JJ denotes spinal
T4081 3059-3063 NN denotes cord
T4084 3064-3067 CC denotes and
T4085 3068-3077 VBN denotes descended
T4086 3078-3086 RB denotes medially
T4087 3087-3089 IN denotes in
T4088 3090-3091 DT denotes a
T4089 3092-3098 NN denotes manner
T4090 3099-3106 JJ denotes similar
T4091 3107-3109 IN denotes to
T4092 3110-3114 DT denotes that
T4093 3115-3119 VBN denotes seen
T4094 3120-3122 IN denotes in
T4095 3123-3125 NN denotes WT
T4097 3126-3128 CC denotes or
T4098 3129-3132 NN denotes Bax
T4099 3133-3135 NN denotes KO
T4096 3136-3141 NNS denotes cases
T4100 3141-3142 . denotes .
T4101 3142-3264 sentence denotes However, it was not possible to follow TrkC immunolabeled fibers all the way to their terminal zones in any of the cases.
T4102 3143-3150 RB denotes However
T4104 3150-3152 , denotes ,
T4105 3152-3154 PRP denotes it
T4103 3155-3158 VBD denotes was
T4106 3159-3162 RB denotes not
T4107 3163-3171 JJ denotes possible
T4108 3172-3174 TO denotes to
T4109 3175-3181 VB denotes follow
T4110 3182-3186 NN denotes TrkC
T4112 3187-3200 VBN denotes immunolabeled
T4111 3201-3207 NNS denotes fibers
T4113 3208-3211 PDT denotes all
T4115 3212-3215 DT denotes the
T4114 3216-3219 NN denotes way
T4116 3220-3222 IN denotes to
T4117 3223-3228 PRP$ denotes their
T4119 3229-3237 JJ denotes terminal
T4118 3238-3243 NNS denotes zones
T4120 3244-3246 IN denotes in
T4121 3247-3250 DT denotes any
T4122 3251-3253 IN denotes of
T4123 3254-3257 DT denotes the
T4124 3258-3263 NNS denotes cases
T4125 3263-3264 . denotes .
T4126 3264-3356 sentence denotes Next we examined the central projections of DRG axons with the lipophilic tracer DiI at P0.
T4127 3265-3269 RB denotes Next
T4129 3270-3272 PRP denotes we
T4128 3273-3281 VBD denotes examined
T4130 3282-3285 DT denotes the
T4132 3286-3293 JJ denotes central
T4131 3294-3305 NNS denotes projections
T4133 3306-3308 IN denotes of
T4134 3309-3312 NN denotes DRG
T4135 3313-3318 NNS denotes axons
T4136 3319-3323 IN denotes with
T4137 3324-3327 DT denotes the
T4139 3328-3338 JJ denotes lipophilic
T4138 3339-3345 NN denotes tracer
T4140 3346-3349 NN denotes DiI
T4141 3350-3352 IN denotes at
T4142 3353-3355 NN denotes P0
T4143 3355-3356 . denotes .
T4144 3356-3490 sentence denotes In WT and Bax KO pups, proprioceptive afferents entered the dorsal spinal cord and followed a medial course towards the ventral horn.
T4145 3357-3359 IN denotes In
T4147 3360-3362 NN denotes WT
T4149 3363-3366 CC denotes and
T4150 3367-3370 NN denotes Bax
T4151 3371-3373 NN denotes KO
T4148 3374-3378 NNS denotes pups
T4152 3378-3380 , denotes ,
T4153 3380-3394 JJ denotes proprioceptive
T4154 3395-3404 NNS denotes afferents
T4146 3405-3412 VBD denotes entered
T4155 3413-3416 DT denotes the
T4157 3417-3423 JJ denotes dorsal
T4158 3424-3430 JJ denotes spinal
T4156 3431-3435 NN denotes cord
T4159 3436-3439 CC denotes and
T4160 3440-3448 VBD denotes followed
T4161 3449-3450 DT denotes a
T4163 3451-3457 JJ denotes medial
T4162 3458-3464 NN denotes course
T4164 3465-3472 IN denotes towards
T4165 3473-3476 DT denotes the
T4167 3477-3484 JJ denotes ventral
T4166 3485-3489 NN denotes horn
T4168 3489-3490 . denotes .
T4169 3490-3616 sentence denotes They then turned laterally towards motor neurons in the lateral motor column, where they branched and terminated (Figure 2A).
T4170 3491-3495 PRP denotes They
T4172 3496-3500 RB denotes then
T4171 3501-3507 VBD denotes turned
T4173 3508-3517 RB denotes laterally
T4174 3518-3525 IN denotes towards
T4175 3526-3531 NN denotes motor
T4176 3532-3539 NNS denotes neurons
T4177 3540-3542 IN denotes in
T4178 3543-3546 DT denotes the
T4180 3547-3554 JJ denotes lateral
T4181 3555-3560 NN denotes motor
T4179 3561-3567 NN denotes column
T4182 3567-3569 , denotes ,
T4183 3569-3574 WRB denotes where
T4185 3575-3579 PRP denotes they
T4184 3580-3588 VBD denotes branched
T4186 3589-3592 CC denotes and
T4187 3593-3603 VBD denotes terminated
T4188 3604-3605 -LRB- denotes (
T4190 3605-3611 NN denotes Figure
T4189 3612-3614 NN denotes 2A
T4191 3614-3615 -RRB- denotes )
T4192 3615-3616 . denotes .
T4193 3616-3822 sentence denotes DiI labeling was confined to dorsal spinal cord in NT-3 KOs (Figure 2A), as reported earlier, consistent with a complete absence of proprioceptive innervation (Ernfors et al. 1994; Tessarollo et al. 1994).
T4194 3617-3620 NN denotes DiI
T4195 3621-3629 NN denotes labeling
T4197 3630-3633 VBD denotes was
T4196 3634-3642 VBN denotes confined
T4198 3643-3645 IN denotes to
T4199 3646-3652 JJ denotes dorsal
T4201 3653-3659 JJ denotes spinal
T4200 3660-3664 NN denotes cord
T4202 3665-3667 IN denotes in
T4203 3668-3670 NN denotes NT
T4205 3670-3671 HYPH denotes -
T4206 3671-3672 CD denotes 3
T4204 3673-3676 NNS denotes KOs
T4207 3677-3678 -LRB- denotes (
T4209 3678-3684 NN denotes Figure
T4208 3685-3687 NN denotes 2A
T4210 3687-3688 -RRB- denotes )
T4211 3688-3690 , denotes ,
T4212 3690-3692 IN denotes as
T4213 3693-3701 VBN denotes reported
T4214 3702-3709 RB denotes earlier
T4215 3709-3711 , denotes ,
T4216 3711-3721 JJ denotes consistent
T4217 3722-3726 IN denotes with
T4218 3727-3728 DT denotes a
T4220 3729-3737 JJ denotes complete
T4219 3738-3745 NN denotes absence
T4221 3746-3748 IN denotes of
T4222 3749-3763 JJ denotes proprioceptive
T4223 3764-3775 NN denotes innervation
T4224 3776-3777 -LRB- denotes (
T4225 3777-3784 NNP denotes Ernfors
T4226 3785-3787 FW denotes et
T4227 3788-3791 FW denotes al.
T4228 3792-3796 CD denotes 1994
T4229 3796-3797 : denotes ;
T4230 3798-3808 NNP denotes Tessarollo
T4231 3809-3811 FW denotes et
T4232 3812-3815 FW denotes al.
T4233 3816-3820 CD denotes 1994
T4234 3820-3821 -RRB- denotes )
T4235 3821-3822 . denotes .
T4236 3822-4032 sentence denotes In double KOs, proprioceptive afferents initially followed a trajectory similar to that of WT counterparts, but most of them failed to project all the way to the ventral cord and into the lateral motor column.
T4237 3823-3825 IN denotes In
T4239 3826-3832 JJ denotes double
T4240 3833-3836 NNS denotes KOs
T4241 3836-3838 , denotes ,
T4242 3838-3852 JJ denotes proprioceptive
T4243 3853-3862 NNS denotes afferents
T4244 3863-3872 RB denotes initially
T4238 3873-3881 VBD denotes followed
T4245 3882-3883 DT denotes a
T4246 3884-3894 NN denotes trajectory
T4247 3895-3902 JJ denotes similar
T4248 3903-3905 IN denotes to
T4249 3906-3910 DT denotes that
T4250 3911-3913 IN denotes of
T4251 3914-3916 NN denotes WT
T4252 3917-3929 NNS denotes counterparts
T4253 3929-3931 , denotes ,
T4254 3931-3934 CC denotes but
T4255 3935-3939 JJS denotes most
T4257 3940-3942 IN denotes of
T4258 3943-3947 PRP denotes them
T4256 3948-3954 VBD denotes failed
T4259 3955-3957 TO denotes to
T4260 3958-3965 VB denotes project
T4261 3966-3969 PDT denotes all
T4263 3970-3973 DT denotes the
T4262 3974-3977 NN denotes way
T4264 3978-3980 IN denotes to
T4265 3981-3984 DT denotes the
T4267 3985-3992 JJ denotes ventral
T4266 3993-3997 NN denotes cord
T4268 3998-4001 CC denotes and
T4269 4002-4006 IN denotes into
T4270 4007-4010 DT denotes the
T4272 4011-4018 JJ denotes lateral
T4273 4019-4024 NN denotes motor
T4271 4025-4031 NN denotes column
T4274 4031-4032 . denotes .
T4275 4032-4176 sentence denotes Instead, they arborized near the ventral midline; some crossed the midline and extended into the contralateral ventral cord (Figure 2A and 2C).
T4276 4033-4040 RB denotes Instead
T4278 4040-4042 , denotes ,
T4279 4042-4046 PRP denotes they
T4277 4047-4056 VBD denotes arborized
T4281 4057-4061 IN denotes near
T4282 4062-4065 DT denotes the
T4284 4066-4073 JJ denotes ventral
T4283 4074-4081 NN denotes midline
T4285 4081-4082 : denotes ;
T4286 4083-4087 DT denotes some
T4280 4088-4095 VBD denotes crossed
T4287 4096-4099 DT denotes the
T4288 4100-4107 NN denotes midline
T4289 4108-4111 CC denotes and
T4290 4112-4120 VBD denotes extended
T4291 4121-4125 IN denotes into
T4292 4126-4129 DT denotes the
T4294 4130-4143 JJ denotes contralateral
T4295 4144-4151 JJ denotes ventral
T4293 4152-4156 NN denotes cord
T4296 4157-4158 -LRB- denotes (
T4298 4158-4164 NN denotes Figure
T4297 4165-4167 NN denotes 2A
T4299 4168-4171 CC denotes and
T4300 4172-4174 NN denotes 2C
T4301 4174-4175 -RRB- denotes )
T4302 4175-4176 . denotes .
T4303 4176-4331 sentence denotes In order to distinguish between a role for NT-3 in initiation of motor neuron innervation and a role for maintenance, we repeated the DiI labeling at E17.
T4304 4177-4179 IN denotes In
T4306 4180-4185 NN denotes order
T4307 4186-4188 TO denotes to
T4308 4189-4200 VB denotes distinguish
T4309 4201-4208 IN denotes between
T4310 4209-4210 DT denotes a
T4311 4211-4215 NN denotes role
T4312 4216-4219 IN denotes for
T4313 4220-4222 NN denotes NT
T4314 4222-4223 HYPH denotes -
T4315 4223-4224 CD denotes 3
T4316 4225-4227 IN denotes in
T4317 4228-4238 NN denotes initiation
T4318 4239-4241 IN denotes of
T4319 4242-4247 NN denotes motor
T4320 4248-4254 NN denotes neuron
T4321 4255-4266 NN denotes innervation
T4322 4267-4270 CC denotes and
T4323 4271-4272 DT denotes a
T4324 4273-4277 NN denotes role
T4325 4278-4281 IN denotes for
T4326 4282-4293 NN denotes maintenance
T4327 4293-4295 , denotes ,
T4328 4295-4297 PRP denotes we
T4305 4298-4306 VBD denotes repeated
T4329 4307-4310 DT denotes the
T4331 4311-4314 NN denotes DiI
T4330 4315-4323 NN denotes labeling
T4332 4324-4326 IN denotes at
T4333 4327-4330 NN denotes E17
T4334 4330-4331 . denotes .
T4335 4331-4423 sentence denotes Innervation patterns of E17 spinal cords (Figure 3) were similar to those at P0 (Figure 2).
T4336 4332-4343 NN denotes Innervation
T4337 4344-4352 NNS denotes patterns
T4339 4353-4355 IN denotes of
T4340 4356-4359 NN denotes E17
T4342 4360-4366 JJ denotes spinal
T4341 4367-4372 NNS denotes cords
T4343 4373-4374 -LRB- denotes (
T4344 4374-4380 NN denotes Figure
T4345 4381-4382 CD denotes 3
T4346 4382-4383 -RRB- denotes )
T4338 4384-4388 VBD denotes were
T4347 4389-4396 JJ denotes similar
T4348 4397-4399 IN denotes to
T4349 4400-4405 DT denotes those
T4350 4406-4408 IN denotes at
T4351 4409-4411 NN denotes P0
T4352 4412-4413 -LRB- denotes (
T4353 4413-4419 NN denotes Figure
T4354 4420-4421 CD denotes 2
T4355 4421-4422 -RRB- denotes )
T4356 4422-4423 . denotes .
T4357 4423-4555 sentence denotes Dorsal horns of all genotypes were filled with DiI-labeled fibers corresponding to nerve growth factor–dependent nociceptive axons.
T4358 4424-4430 JJ denotes Dorsal
T4359 4431-4436 NNS denotes horns
T4361 4437-4439 IN denotes of
T4362 4440-4443 DT denotes all
T4363 4444-4453 NNS denotes genotypes
T4364 4454-4458 VBD denotes were
T4360 4459-4465 VBN denotes filled
T4365 4466-4470 IN denotes with
T4366 4471-4474 NN denotes DiI
T4368 4474-4475 HYPH denotes -
T4367 4475-4482 VBN denotes labeled
T4369 4483-4489 NNS denotes fibers
T4370 4490-4503 VBG denotes corresponding
T4371 4504-4506 IN denotes to
T4372 4507-4512 NN denotes nerve
T4374 4513-4519 NN denotes growth
T4373 4520-4526 NN denotes factor
T4376 4526-4527 HYPH denotes –
T4375 4527-4536 JJ denotes dependent
T4378 4537-4548 JJ denotes nociceptive
T4377 4549-4554 NNS denotes axons
T4379 4554-4555 . denotes .
T4380 4555-4756 sentence denotes In WT and Bax KO embryos, proprioceptive fibers extended towards ventral horn motor neurons (Figure 3A and 3B), whereas the ventral horns of the NT-3 KO embryos were devoid of innervation (Figure 3C).
T4381 4556-4558 IN denotes In
T4383 4559-4561 NN denotes WT
T4385 4562-4565 CC denotes and
T4386 4566-4569 NN denotes Bax
T4387 4570-4572 NN denotes KO
T4384 4573-4580 NNS denotes embryos
T4388 4580-4582 , denotes ,
T4389 4582-4596 JJ denotes proprioceptive
T4390 4597-4603 NNS denotes fibers
T4382 4604-4612 VBN denotes extended
T4391 4613-4620 IN denotes towards
T4392 4621-4628 JJ denotes ventral
T4393 4629-4633 NN denotes horn
T4395 4634-4639 NN denotes motor
T4394 4640-4647 NNS denotes neurons
T4396 4648-4649 -LRB- denotes (
T4398 4649-4655 NN denotes Figure
T4397 4656-4658 NN denotes 3A
T4399 4659-4662 CC denotes and
T4400 4663-4665 NN denotes 3B
T4401 4665-4666 -RRB- denotes )
T4402 4666-4668 , denotes ,
T4403 4668-4675 IN denotes whereas
T4405 4676-4679 DT denotes the
T4407 4680-4687 JJ denotes ventral
T4406 4688-4693 NNS denotes horns
T4408 4694-4696 IN denotes of
T4409 4697-4700 DT denotes the
T4411 4701-4703 NN denotes NT
T4413 4703-4704 HYPH denotes -
T4414 4704-4705 CD denotes 3
T4412 4706-4708 NN denotes KO
T4410 4709-4716 NNS denotes embryos
T4404 4717-4721 VBD denotes were
T4415 4722-4728 JJ denotes devoid
T4416 4729-4731 IN denotes of
T4417 4732-4743 NN denotes innervation
T4418 4744-4745 -LRB- denotes (
T4420 4745-4751 NN denotes Figure
T4419 4752-4754 NN denotes 3C
T4421 4754-4755 -RRB- denotes )
T4422 4755-4756 . denotes .
T4423 4756-4955 sentence denotes In the Bax/NT-3 double KOs, DiI-labeled fibers entered the ventral spinal cord, but extended towards the midline instead of the ventral horn (Figure 3D), in a pattern similar to that observed at P0.
T4424 4757-4759 IN denotes In
T4426 4760-4763 DT denotes the
T4428 4764-4767 NN denotes Bax
T4429 4767-4768 HYPH denotes /
T4430 4768-4770 NN denotes NT
T4431 4770-4771 HYPH denotes -
T4432 4771-4772 CD denotes 3
T4433 4773-4779 JJ denotes double
T4427 4780-4783 NNS denotes KOs
T4434 4783-4785 , denotes ,
T4435 4785-4788 NN denotes DiI
T4437 4788-4789 HYPH denotes -
T4436 4789-4796 VBN denotes labeled
T4438 4797-4803 NNS denotes fibers
T4425 4804-4811 VBD denotes entered
T4439 4812-4815 DT denotes the
T4441 4816-4823 JJ denotes ventral
T4442 4824-4830 JJ denotes spinal
T4440 4831-4835 NN denotes cord
T4443 4835-4837 , denotes ,
T4444 4837-4840 CC denotes but
T4445 4841-4849 VBD denotes extended
T4446 4850-4857 IN denotes towards
T4447 4858-4861 DT denotes the
T4448 4862-4869 NN denotes midline
T4449 4870-4877 RB denotes instead
T4450 4878-4880 IN denotes of
T4451 4881-4884 DT denotes the
T4453 4885-4892 JJ denotes ventral
T4452 4893-4897 NN denotes horn
T4454 4898-4899 -LRB- denotes (
T4456 4899-4905 NN denotes Figure
T4455 4906-4908 NN denotes 3D
T4457 4908-4909 -RRB- denotes )
T4458 4909-4911 , denotes ,
T4459 4911-4913 IN denotes in
T4460 4914-4915 DT denotes a
T4461 4916-4923 NN denotes pattern
T4462 4924-4931 JJ denotes similar
T4463 4932-4934 IN denotes to
T4464 4935-4939 DT denotes that
T4465 4940-4948 VBN denotes observed
T4466 4949-4951 IN denotes at
T4467 4952-4954 NN denotes P0
T4468 4954-4955 . denotes .
T4469 4955-5125 sentence denotes Our data point to a complete absence of proprioceptive innervation of the ventral horn of the Bax/NT-3 null spinal cord throughout the developmental stages investigated.
T4470 4956-4959 PRP$ denotes Our
T4471 4960-4964 NNS denotes data
T4472 4965-4970 VBP denotes point
T4473 4971-4973 IN denotes to
T4474 4974-4975 DT denotes a
T4476 4976-4984 JJ denotes complete
T4475 4985-4992 NN denotes absence
T4477 4993-4995 IN denotes of
T4478 4996-5010 JJ denotes proprioceptive
T4479 5011-5022 NN denotes innervation
T4480 5023-5025 IN denotes of
T4481 5026-5029 DT denotes the
T4483 5030-5037 JJ denotes ventral
T4482 5038-5042 NN denotes horn
T4484 5043-5045 IN denotes of
T4485 5046-5049 DT denotes the
T4487 5050-5053 NN denotes Bax
T4489 5053-5054 HYPH denotes /
T4490 5054-5056 NN denotes NT
T4491 5056-5057 HYPH denotes -
T4492 5057-5058 CD denotes 3
T4488 5059-5063 JJ denotes null
T4493 5064-5070 JJ denotes spinal
T4486 5071-5075 NN denotes cord
T4494 5076-5086 IN denotes throughout
T4495 5087-5090 DT denotes the
T4497 5091-5104 JJ denotes developmental
T4496 5105-5111 NNS denotes stages
T4498 5112-5124 VBN denotes investigated
T4499 5124-5125 . denotes .
T4500 5125-5265 sentence denotes As the sensory axons never reach motor neuron dendrites in the ventral horn (Figure S1), the stretch reflex arc circuit is not established.
T4501 5126-5128 IN denotes As
T4503 5129-5132 DT denotes the
T4505 5133-5140 JJ denotes sensory
T4504 5141-5146 NNS denotes axons
T4506 5147-5152 RB denotes never
T4502 5153-5158 VBP denotes reach
T4508 5159-5164 NN denotes motor
T4509 5165-5171 NN denotes neuron
T4510 5172-5181 NNS denotes dendrites
T4511 5182-5184 IN denotes in
T4512 5185-5188 DT denotes the
T4514 5189-5196 JJ denotes ventral
T4513 5197-5201 NN denotes horn
T4515 5202-5203 -LRB- denotes (
T4517 5203-5209 NN denotes Figure
T4516 5210-5212 NN denotes S1
T4518 5212-5213 -RRB- denotes )
T4519 5213-5215 , denotes ,
T4520 5215-5218 DT denotes the
T4522 5219-5226 NN denotes stretch
T4523 5227-5233 NN denotes reflex
T4524 5234-5237 NN denotes arc
T4521 5238-5245 NN denotes circuit
T4525 5246-5248 VBZ denotes is
T4526 5249-5252 RB denotes not
T4507 5253-5264 VBN denotes established
T4527 5264-5265 . denotes .
T4528 5265-5469 sentence denotes The failure to initiate contact between sensory axons and motor neurons in the absence of NT-3 suggests a requirement for NT-3 for proper axon targeting in addition to a role in sensory axon maintenance.
T4529 5266-5269 DT denotes The
T4530 5270-5277 NN denotes failure
T4532 5278-5280 TO denotes to
T4533 5281-5289 VB denotes initiate
T4534 5290-5297 NN denotes contact
T4535 5298-5305 IN denotes between
T4536 5306-5313 JJ denotes sensory
T4537 5314-5319 NNS denotes axons
T4538 5320-5323 CC denotes and
T4539 5324-5329 NN denotes motor
T4540 5330-5337 NNS denotes neurons
T4541 5338-5340 IN denotes in
T4542 5341-5344 DT denotes the
T4543 5345-5352 NN denotes absence
T4544 5353-5355 IN denotes of
T4545 5356-5358 NN denotes NT
T4546 5358-5359 HYPH denotes -
T4547 5359-5360 CD denotes 3
T4531 5361-5369 VBZ denotes suggests
T4548 5370-5371 DT denotes a
T4549 5372-5383 NN denotes requirement
T4550 5384-5387 IN denotes for
T4551 5388-5390 NN denotes NT
T4552 5390-5391 HYPH denotes -
T4553 5391-5392 CD denotes 3
T4554 5393-5396 IN denotes for
T4555 5397-5403 JJ denotes proper
T4556 5404-5408 NN denotes axon
T4557 5409-5418 VBG denotes targeting
T4558 5419-5421 IN denotes in
T4559 5422-5430 NN denotes addition
T4560 5431-5433 IN denotes to
T4561 5434-5435 DT denotes a
T4562 5436-5440 NN denotes role
T4563 5441-5443 IN denotes in
T4564 5444-5451 JJ denotes sensory
T4565 5452-5456 NN denotes axon
T4566 5457-5468 NN denotes maintenance
T4567 5468-5469 . denotes .
T5932 6742-6744 NN denotes NT
T5934 6744-6745 HYPH denotes -
T5935 6745-6746 CD denotes 3
T5936 6747-6749 VBZ denotes Is
T5933 6750-6758 VBN denotes Required
T5937 6759-6762 IN denotes for
T5938 6763-6769 JJ denotes Proper
T5940 6770-6780 JJ denotes Peripheral
T5939 6781-6792 NN denotes Innervation
T5941 6792-6920 sentence denotes In order to study peripheral innervation in double KO animals, we investigated spindle development in the gastrocnemius muscle.
T5942 6793-6795 IN denotes In
T5944 6796-6801 NN denotes order
T5945 6802-6804 TO denotes to
T5946 6805-6810 VB denotes study
T5947 6811-6821 JJ denotes peripheral
T5948 6822-6833 NN denotes innervation
T5949 6834-6836 IN denotes in
T5950 6837-6843 JJ denotes double
T5951 6844-6846 NN denotes KO
T5952 6847-6854 NNS denotes animals
T5953 6854-6856 , denotes ,
T5954 6856-6858 PRP denotes we
T5943 6859-6871 VBD denotes investigated
T5955 6872-6879 NN denotes spindle
T5956 6880-6891 NN denotes development
T5957 6892-6894 IN denotes in
T5958 6895-6898 DT denotes the
T5960 6899-6912 NN denotes gastrocnemius
T5959 6913-6919 NN denotes muscle
T5961 6919-6920 . denotes .
T5962 6920-7046 sentence denotes Muscle spindles could be identified easily in P0 WT and Bax KO animals by their characteristic morphology (Figure 4A and 4B).
T5963 6921-6927 NN denotes Muscle
T5964 6928-6936 NNS denotes spindles
T5966 6937-6942 MD denotes could
T5967 6943-6945 VB denotes be
T5965 6946-6956 VBN denotes identified
T5968 6957-6963 RB denotes easily
T5969 6964-6966 IN denotes in
T5970 6967-6969 NN denotes P0
T5972 6970-6972 NN denotes WT
T5973 6973-6976 CC denotes and
T5974 6977-6980 NN denotes Bax
T5975 6981-6983 NN denotes KO
T5971 6984-6991 NNS denotes animals
T5976 6992-6994 IN denotes by
T5977 6995-7000 PRP$ denotes their
T5979 7001-7015 JJ denotes characteristic
T5978 7016-7026 NN denotes morphology
T5980 7027-7028 -LRB- denotes (
T5982 7028-7034 NN denotes Figure
T5981 7035-7037 NN denotes 4A
T5983 7038-7041 CC denotes and
T5984 7042-7044 NN denotes 4B
T5985 7044-7045 -RRB- denotes )
T5986 7045-7046 . denotes .
T5987 7046-7290 sentence denotes Proprioceptive fibers labeled with neurofilament-M (NF-M) antibody formed ring-like spiral endings wrapped around intrafusal bag fibers labeled with S46 antibody, specific for slow developmental myosin heavy chain protein (Miller et al. 1985).
T5988 7047-7061 JJ denotes Proprioceptive
T5989 7062-7068 NNS denotes fibers
T5991 7069-7076 VBN denotes labeled
T5992 7077-7081 IN denotes with
T5993 7082-7095 NN denotes neurofilament
T5995 7095-7096 HYPH denotes -
T5994 7096-7097 NN denotes M
T5997 7098-7099 -LRB- denotes (
T5998 7099-7101 NN denotes NF
T6000 7101-7102 HYPH denotes -
T5999 7102-7103 NN denotes M
T6001 7103-7104 -RRB- denotes )
T5996 7105-7113 NN denotes antibody
T5990 7114-7120 VBD denotes formed
T6002 7121-7125 NN denotes ring
T6004 7125-7126 HYPH denotes -
T6003 7126-7130 JJ denotes like
T6006 7131-7137 JJ denotes spiral
T6005 7138-7145 NNS denotes endings
T6007 7146-7153 VBN denotes wrapped
T6008 7154-7160 IN denotes around
T6009 7161-7171 JJ denotes intrafusal
T6011 7172-7175 NN denotes bag
T6010 7176-7182 NNS denotes fibers
T6012 7183-7190 VBN denotes labeled
T6013 7191-7195 IN denotes with
T6014 7196-7199 NN denotes S46
T6015 7200-7208 NN denotes antibody
T6016 7208-7210 , denotes ,
T6017 7210-7218 JJ denotes specific
T6018 7219-7222 IN denotes for
T6019 7223-7227 JJ denotes slow
T6020 7228-7241 JJ denotes developmental
T6022 7242-7248 NN denotes myosin
T6023 7249-7254 JJ denotes heavy
T6024 7255-7260 NN denotes chain
T6021 7261-7268 NN denotes protein
T6025 7269-7270 -LRB- denotes (
T6026 7270-7276 NNP denotes Miller
T6027 7277-7279 FW denotes et
T6028 7280-7283 FW denotes al.
T6029 7284-7288 CD denotes 1985
T6030 7288-7289 -RRB- denotes )
T6031 7289-7290 . denotes .
T6032 7290-7383 sentence denotes As reported earlier, there were no muscle spindles in NT-3 KO animals (Ernfors et al. 1994).
T6033 7291-7293 IN denotes As
T6034 7294-7302 VBN denotes reported
T6036 7303-7310 RBR denotes earlier
T6037 7310-7312 , denotes ,
T6038 7312-7317 EX denotes there
T6035 7318-7322 VBD denotes were
T6039 7323-7325 DT denotes no
T6041 7326-7332 NN denotes muscle
T6040 7333-7341 NNS denotes spindles
T6042 7342-7344 IN denotes in
T6043 7345-7347 NN denotes NT
T6045 7347-7348 HYPH denotes -
T6046 7348-7349 CD denotes 3
T6044 7350-7352 NN denotes KO
T6047 7353-7360 NNS denotes animals
T6048 7361-7362 -LRB- denotes (
T6049 7362-7369 NNP denotes Ernfors
T6050 7370-7372 FW denotes et
T6051 7373-7376 FW denotes al.
T6052 7377-7381 CD denotes 1994
T6053 7381-7382 -RRB- denotes )
T6054 7382-7383 . denotes .
T6055 7383-7550 sentence denotes On the other hand, Bax KO animals had more spindles than WT, and spindles were in clusters similar to animals over-expressing NT-3 in the muscle (Wright et al. 1997).
T6056 7384-7386 IN denotes On
T6058 7387-7390 DT denotes the
T6060 7391-7396 JJ denotes other
T6059 7397-7401 NN denotes hand
T6061 7401-7403 , denotes ,
T6062 7403-7406 NN denotes Bax
T6063 7407-7409 NN denotes KO
T6064 7410-7417 NNS denotes animals
T6057 7418-7421 VBD denotes had
T6065 7422-7426 JJR denotes more
T6066 7427-7435 NNS denotes spindles
T6067 7436-7440 IN denotes than
T6068 7441-7443 NN denotes WT
T6069 7443-7445 , denotes ,
T6070 7445-7448 CC denotes and
T6071 7449-7457 NNS denotes spindles
T6072 7458-7462 VBD denotes were
T6073 7463-7465 IN denotes in
T6074 7466-7474 NNS denotes clusters
T6075 7475-7482 JJ denotes similar
T6076 7483-7485 IN denotes to
T6077 7486-7493 NNS denotes animals
T6078 7494-7509 VBG denotes over-expressing
T6079 7510-7512 NN denotes NT
T6080 7512-7513 HYPH denotes -
T6081 7513-7514 CD denotes 3
T6082 7515-7517 IN denotes in
T6083 7518-7521 DT denotes the
T6084 7522-7528 NN denotes muscle
T6085 7529-7530 -LRB- denotes (
T6086 7530-7536 NNP denotes Wright
T6087 7537-7539 FW denotes et
T6088 7540-7543 FW denotes al.
T6089 7544-7548 CD denotes 1997
T6090 7548-7549 -RRB- denotes )
T6091 7549-7550 . denotes .
T6092 7550-7674 sentence denotes Although NT-3-dependent cells were rescued, no muscle spindles were detected in the limbs of double KOs (Figure 4A and 4B).
T6093 7551-7559 IN denotes Although
T6095 7560-7562 NN denotes NT
T6097 7562-7563 HYPH denotes -
T6098 7563-7564 CD denotes 3
T6099 7564-7565 HYPH denotes -
T6096 7565-7574 JJ denotes dependent
T6100 7575-7580 NNS denotes cells
T6101 7581-7585 VBD denotes were
T6094 7586-7593 VBN denotes rescued
T6103 7593-7595 , denotes ,
T6104 7595-7597 DT denotes no
T6106 7598-7604 NN denotes muscle
T6105 7605-7613 NNS denotes spindles
T6107 7614-7618 VBD denotes were
T6102 7619-7627 VBN denotes detected
T6108 7628-7630 IN denotes in
T6109 7631-7634 DT denotes the
T6110 7635-7640 NNS denotes limbs
T6111 7641-7643 IN denotes of
T6112 7644-7650 JJ denotes double
T6113 7651-7654 NNS denotes KOs
T6114 7655-7656 -LRB- denotes (
T6116 7656-7662 NN denotes Figure
T6115 7663-7665 NN denotes 4A
T6117 7666-7669 CC denotes and
T6118 7670-7672 NN denotes 4B
T6119 7672-7673 -RRB- denotes )
T6120 7673-7674 . denotes .
T6121 7674-7796 sentence denotes Muscle spindles could be observed with TrkC antibody in WT and Bax KO animals, but not in NT-3 or double KOs (Figure 4E).
T6122 7675-7681 NN denotes Muscle
T6123 7682-7690 NNS denotes spindles
T6125 7691-7696 MD denotes could
T6126 7697-7699 VB denotes be
T6124 7700-7708 VBN denotes observed
T6127 7709-7713 IN denotes with
T6128 7714-7718 NN denotes TrkC
T6129 7719-7727 NN denotes antibody
T6130 7728-7730 IN denotes in
T6131 7731-7733 NN denotes WT
T6133 7734-7737 CC denotes and
T6134 7738-7741 NN denotes Bax
T6135 7742-7744 NN denotes KO
T6132 7745-7752 NNS denotes animals
T6136 7752-7754 , denotes ,
T6137 7754-7757 CC denotes but
T6138 7758-7761 RB denotes not
T6139 7762-7764 IN denotes in
T6140 7765-7767 NN denotes NT
T6142 7767-7768 HYPH denotes -
T6143 7768-7769 CD denotes 3
T6144 7770-7772 CC denotes or
T6145 7773-7779 JJ denotes double
T6141 7780-7783 NNS denotes KOs
T6146 7784-7785 -LRB- denotes (
T6148 7785-7791 NN denotes Figure
T6147 7792-7794 NN denotes 4E
T6149 7794-7795 -RRB- denotes )
T6150 7795-7796 . denotes .
T6151 7796-7960 sentence denotes In both NT-3 and double KO animals, NF-M-labeled fibers could be detected in muscles, thus the muscles of these animals were not completely devoid of nerve fibers.
T6152 7797-7799 IN denotes In
T6154 7800-7804 CC denotes both
T6155 7805-7807 NN denotes NT
T6157 7807-7808 HYPH denotes -
T6158 7808-7809 CD denotes 3
T6159 7810-7813 CC denotes and
T6160 7814-7820 JJ denotes double
T6156 7821-7823 NN denotes KO
T6161 7824-7831 NNS denotes animals
T6162 7831-7833 , denotes ,
T6163 7833-7835 NN denotes NF
T6165 7835-7836 HYPH denotes -
T6164 7836-7837 NN denotes M
T6167 7837-7838 HYPH denotes -
T6166 7838-7845 VBN denotes labeled
T6168 7846-7852 NNS denotes fibers
T6169 7853-7858 MD denotes could
T6170 7859-7861 VB denotes be
T6153 7862-7870 VBN denotes detected
T6172 7871-7873 IN denotes in
T6173 7874-7881 NNS denotes muscles
T6174 7881-7883 , denotes ,
T6175 7883-7887 RB denotes thus
T6176 7888-7891 DT denotes the
T6177 7892-7899 NNS denotes muscles
T6178 7900-7902 IN denotes of
T6179 7903-7908 DT denotes these
T6180 7909-7916 NNS denotes animals
T6171 7917-7921 VBD denotes were
T6181 7922-7925 RB denotes not
T6182 7926-7936 RB denotes completely
T6183 7937-7943 JJ denotes devoid
T6184 7944-7946 IN denotes of
T6185 7947-7952 NN denotes nerve
T6186 7953-7959 NNS denotes fibers
T6187 7959-7960 . denotes .
T6188 7960-8086 sentence denotes Since there were no TrkC-positive fibers in these muscles, we think that these NF-M-labeled fibers correspond to motor axons.
T6189 7961-7966 IN denotes Since
T6191 7967-7972 EX denotes there
T6190 7973-7977 VBD denotes were
T6193 7978-7980 DT denotes no
T6195 7981-7985 NN denotes TrkC
T6196 7985-7986 HYPH denotes -
T6197 7986-7994 JJ denotes positive
T6194 7995-8001 NNS denotes fibers
T6198 8002-8004 IN denotes in
T6199 8005-8010 DT denotes these
T6200 8011-8018 NNS denotes muscles
T6201 8018-8020 , denotes ,
T6202 8020-8022 PRP denotes we
T6192 8023-8028 VBP denotes think
T6203 8029-8033 IN denotes that
T6205 8034-8039 DT denotes these
T6207 8040-8042 NN denotes NF
T6209 8042-8043 HYPH denotes -
T6208 8043-8044 NN denotes M
T6211 8044-8045 HYPH denotes -
T6210 8045-8052 VBN denotes labeled
T6206 8053-8059 NNS denotes fibers
T6204 8060-8070 VBP denotes correspond
T6212 8071-8073 IN denotes to
T6213 8074-8079 NN denotes motor
T6214 8080-8085 NNS denotes axons
T6215 8085-8086 . denotes .
T6216 8086-8264 sentence denotes Absence of muscle spindles might be due to a failure in initiation of differentiation by proprioceptive axons, or a failure of maturation and maintenance in the absence of NT-3.
T6217 8087-8094 NN denotes Absence
T6219 8095-8097 IN denotes of
T6220 8098-8104 NN denotes muscle
T6221 8105-8113 NNS denotes spindles
T6222 8114-8119 MD denotes might
T6218 8120-8122 VB denotes be
T6223 8123-8126 IN denotes due
T6224 8127-8129 IN denotes to
T6225 8130-8131 DT denotes a
T6226 8132-8139 NN denotes failure
T6227 8140-8142 IN denotes in
T6228 8143-8153 NN denotes initiation
T6229 8154-8156 IN denotes of
T6230 8157-8172 NN denotes differentiation
T6231 8173-8175 IN denotes by
T6232 8176-8190 JJ denotes proprioceptive
T6233 8191-8196 NNS denotes axons
T6234 8196-8198 , denotes ,
T6235 8198-8200 CC denotes or
T6236 8201-8202 DT denotes a
T6237 8203-8210 NN denotes failure
T6238 8211-8213 IN denotes of
T6239 8214-8224 NN denotes maturation
T6240 8225-8228 CC denotes and
T6241 8229-8240 NN denotes maintenance
T6242 8241-8243 IN denotes in
T6243 8244-8247 DT denotes the
T6244 8248-8255 NN denotes absence
T6245 8256-8258 IN denotes of
T6246 8259-8261 NN denotes NT
T6247 8261-8262 HYPH denotes -
T6248 8262-8263 CD denotes 3
T6249 8263-8264 . denotes .
T6250 8264-8424 sentence denotes To distinguish between these two possibilities, we investigated muscle spindle development at E15 and E17 with S46/NF-M immunostaining as well as DiI labeling.
T6251 8265-8267 TO denotes To
T6252 8268-8279 VB denotes distinguish
T6254 8280-8287 IN denotes between
T6255 8288-8293 DT denotes these
T6257 8294-8297 CD denotes two
T6256 8298-8311 NNS denotes possibilities
T6258 8311-8313 , denotes ,
T6259 8313-8315 PRP denotes we
T6253 8316-8328 VBD denotes investigated
T6260 8329-8335 NN denotes muscle
T6261 8336-8343 NN denotes spindle
T6262 8344-8355 NN denotes development
T6263 8356-8358 IN denotes at
T6264 8359-8362 NN denotes E15
T6265 8363-8366 CC denotes and
T6266 8367-8370 NN denotes E17
T6267 8371-8375 IN denotes with
T6268 8376-8379 NN denotes S46
T6270 8379-8380 HYPH denotes /
T6271 8380-8382 NN denotes NF
T6273 8382-8383 HYPH denotes -
T6272 8383-8384 NN denotes M
T6269 8385-8399 NN denotes immunostaining
T6274 8400-8402 RB denotes as
T6276 8403-8407 RB denotes well
T6275 8408-8410 IN denotes as
T6277 8411-8414 NN denotes DiI
T6278 8415-8423 NN denotes labeling
T6279 8423-8424 . denotes .
T6280 8424-8545 sentence denotes No structures with the characteristic muscle spindle shape could be detected in any of the genotypes at E15 (Figure S2).
T6281 8425-8427 DT denotes No
T6282 8428-8438 NNS denotes structures
T6284 8439-8443 IN denotes with
T6285 8444-8447 DT denotes the
T6287 8448-8462 JJ denotes characteristic
T6288 8463-8469 NN denotes muscle
T6289 8470-8477 NN denotes spindle
T6286 8478-8483 NN denotes shape
T6290 8484-8489 MD denotes could
T6291 8490-8492 VB denotes be
T6283 8493-8501 VBN denotes detected
T6292 8502-8504 IN denotes in
T6293 8505-8508 DT denotes any
T6294 8509-8511 IN denotes of
T6295 8512-8515 DT denotes the
T6296 8516-8525 NNS denotes genotypes
T6297 8526-8528 IN denotes at
T6298 8529-8532 NN denotes E15
T6299 8533-8534 -LRB- denotes (
T6301 8534-8540 NN denotes Figure
T6300 8541-8543 NN denotes S2
T6302 8543-8544 -RRB- denotes )
T6303 8544-8545 . denotes .
T6304 8545-8669 sentence denotes However, numerous developing spindles could be identified at E17 in WT and Bax KOs, but not in NT-3 KO embryos (Figure 4C).
T6305 8546-8553 RB denotes However
T6307 8553-8555 , denotes ,
T6308 8555-8563 JJ denotes numerous
T6310 8564-8574 VBG denotes developing
T6309 8575-8583 NNS denotes spindles
T6311 8584-8589 MD denotes could
T6312 8590-8592 VB denotes be
T6306 8593-8603 VBN denotes identified
T6313 8604-8606 IN denotes at
T6314 8607-8610 NN denotes E17
T6315 8611-8613 IN denotes in
T6316 8614-8616 NN denotes WT
T6317 8617-8620 CC denotes and
T6318 8621-8624 NN denotes Bax
T6319 8625-8628 NNS denotes KOs
T6320 8628-8630 , denotes ,
T6321 8630-8633 CC denotes but
T6322 8634-8637 RB denotes not
T6323 8638-8640 IN denotes in
T6324 8641-8643 NN denotes NT
T6326 8643-8644 HYPH denotes -
T6327 8644-8645 CD denotes 3
T6325 8646-8648 NN denotes KO
T6328 8649-8656 NNS denotes embryos
T6329 8657-8658 -LRB- denotes (
T6331 8658-8664 NN denotes Figure
T6330 8665-8667 NN denotes 4C
T6332 8667-8668 -RRB- denotes )
T6333 8668-8669 . denotes .
T6334 8669-8851 sentence denotes Bax/NT-3 double null muscles were devoid of spindles (Figure 4C), except for one spindle-like structure observed in one leg of an embryo (Figure 4C, inset, denoted by the asterisk).
T6335 8670-8673 NN denotes Bax
T6337 8673-8674 HYPH denotes /
T6338 8674-8676 NN denotes NT
T6339 8676-8677 HYPH denotes -
T6340 8677-8678 CD denotes 3
T6341 8679-8685 JJ denotes double
T6336 8686-8690 JJ denotes null
T6342 8691-8698 NNS denotes muscles
T6343 8699-8703 VBD denotes were
T6344 8704-8710 JJ denotes devoid
T6345 8711-8713 IN denotes of
T6346 8714-8722 NNS denotes spindles
T6347 8723-8724 -LRB- denotes (
T6349 8724-8730 NN denotes Figure
T6348 8731-8733 NN denotes 4C
T6350 8733-8734 -RRB- denotes )
T6351 8734-8736 , denotes ,
T6352 8736-8742 IN denotes except
T6353 8743-8746 IN denotes for
T6354 8747-8750 CD denotes one
T6356 8751-8758 NN denotes spindle
T6358 8758-8759 HYPH denotes -
T6357 8759-8763 JJ denotes like
T6355 8764-8773 NN denotes structure
T6359 8774-8782 VBN denotes observed
T6360 8783-8785 IN denotes in
T6361 8786-8789 CD denotes one
T6362 8790-8793 NN denotes leg
T6363 8794-8796 IN denotes of
T6364 8797-8799 DT denotes an
T6365 8800-8806 NN denotes embryo
T6366 8807-8808 -LRB- denotes (
T6368 8808-8814 NN denotes Figure
T6369 8815-8817 NN denotes 4C
T6370 8817-8819 , denotes ,
T6371 8819-8824 NN denotes inset
T6372 8824-8826 , denotes ,
T6367 8826-8833 VBN denotes denoted
T6373 8834-8836 IN denotes by
T6374 8837-8840 DT denotes the
T6375 8841-8849 NN denotes asterisk
T6376 8849-8850 -RRB- denotes )
T6377 8850-8851 . denotes .
T6378 8851-9044 sentence denotes DiI labeling through the DRGs at E17 yielded similar results, with muscle spindles identified in parallel sections in WT and Bax null muscles (Figure 4D), but not in NT-3 or double KO animals.
T6379 8852-8855 NN denotes DiI
T6380 8856-8864 NN denotes labeling
T6382 8865-8872 IN denotes through
T6383 8873-8876 DT denotes the
T6384 8877-8881 NNS denotes DRGs
T6385 8882-8884 IN denotes at
T6386 8885-8888 NN denotes E17
T6381 8889-8896 VBD denotes yielded
T6387 8897-8904 JJ denotes similar
T6388 8905-8912 NNS denotes results
T6389 8912-8914 , denotes ,
T6390 8914-8918 IN denotes with
T6392 8919-8925 NN denotes muscle
T6393 8926-8934 NNS denotes spindles
T6391 8935-8945 VBN denotes identified
T6394 8946-8948 IN denotes in
T6395 8949-8957 JJ denotes parallel
T6396 8958-8966 NNS denotes sections
T6397 8967-8969 IN denotes in
T6398 8970-8972 NN denotes WT
T6400 8973-8976 CC denotes and
T6401 8977-8980 NN denotes Bax
T6402 8981-8985 JJ denotes null
T6399 8986-8993 NNS denotes muscles
T6403 8994-8995 -LRB- denotes (
T6405 8995-9001 NN denotes Figure
T6404 9002-9004 NN denotes 4D
T6406 9004-9005 -RRB- denotes )
T6407 9005-9007 , denotes ,
T6408 9007-9010 CC denotes but
T6409 9011-9014 RB denotes not
T6410 9015-9017 IN denotes in
T6411 9018-9020 NN denotes NT
T6413 9020-9021 HYPH denotes -
T6414 9021-9022 CD denotes 3
T6415 9023-9025 CC denotes or
T6416 9026-9032 JJ denotes double
T6412 9033-9035 NN denotes KO
T6417 9036-9043 NNS denotes animals
T6418 9043-9044 . denotes .
T6419 9044-9188 sentence denotes Although DiI-labeled fibers could be detected in double null muscles, they never formed ring-like structures characteristic of muscle spindles.
T6420 9045-9053 IN denotes Although
T6422 9054-9057 NN denotes DiI
T6424 9057-9058 HYPH denotes -
T6423 9058-9065 VBN denotes labeled
T6425 9066-9072 NNS denotes fibers
T6426 9073-9078 MD denotes could
T6427 9079-9081 VB denotes be
T6421 9082-9090 VBN denotes detected
T6429 9091-9093 IN denotes in
T6430 9094-9100 JJ denotes double
T6431 9101-9105 JJ denotes null
T6432 9106-9113 NNS denotes muscles
T6433 9113-9115 , denotes ,
T6434 9115-9119 PRP denotes they
T6435 9120-9125 RB denotes never
T6428 9126-9132 VBD denotes formed
T6436 9133-9137 NN denotes ring
T6438 9137-9138 HYPH denotes -
T6437 9138-9142 JJ denotes like
T6439 9143-9153 NNS denotes structures
T6440 9154-9168 JJ denotes characteristic
T6441 9169-9171 IN denotes of
T6442 9172-9178 NN denotes muscle
T6443 9179-9187 NNS denotes spindles
T6444 9187-9188 . denotes .
T6445 9188-9348 sentence denotes We also examined TrkA/TrkC expression at P0 in the tibial nerve, which carries sensory fibers to the gastrocnemius muscle as well as the skin of the lower leg.
T6446 9189-9191 PRP denotes We
T6448 9192-9196 RB denotes also
T6447 9197-9205 VBD denotes examined
T6449 9206-9210 NN denotes TrkA
T6451 9210-9211 HYPH denotes /
T6450 9211-9215 NN denotes TrkC
T6452 9216-9226 NN denotes expression
T6453 9227-9229 IN denotes at
T6454 9230-9232 NN denotes P0
T6455 9233-9235 IN denotes in
T6456 9236-9239 DT denotes the
T6458 9240-9246 JJ denotes tibial
T6457 9247-9252 NN denotes nerve
T6459 9252-9254 , denotes ,
T6460 9254-9259 WDT denotes which
T6461 9260-9267 VBZ denotes carries
T6462 9268-9275 JJ denotes sensory
T6463 9276-9282 NNS denotes fibers
T6464 9283-9285 IN denotes to
T6465 9286-9289 DT denotes the
T6467 9290-9303 NN denotes gastrocnemius
T6466 9304-9310 NN denotes muscle
T6468 9311-9313 RB denotes as
T6470 9314-9318 RB denotes well
T6469 9319-9321 IN denotes as
T6471 9322-9325 DT denotes the
T6472 9326-9330 NN denotes skin
T6473 9331-9333 IN denotes of
T6474 9334-9337 DT denotes the
T6476 9338-9343 JJR denotes lower
T6475 9344-9347 NN denotes leg
T6477 9347-9348 . denotes .
T6478 9348-9563 sentence denotes In NT-3 KOs, TrkA-positive axons could be seen in the tibial nerve but there were no TrkC-positive axons; in contrast, TrkA- and TrkC-labeled axons are both present in WT, Bax KO, and double KO animals (Figure 4F).
T6479 9349-9351 IN denotes In
T6481 9352-9354 NN denotes NT
T6483 9354-9355 HYPH denotes -
T6484 9355-9356 CD denotes 3
T6482 9357-9360 NNS denotes KOs
T6485 9360-9362 , denotes ,
T6486 9362-9366 NN denotes TrkA
T6488 9366-9367 HYPH denotes -
T6487 9367-9375 JJ denotes positive
T6489 9376-9381 NNS denotes axons
T6490 9382-9387 MD denotes could
T6491 9388-9390 VB denotes be
T6480 9391-9395 VBN denotes seen
T6493 9396-9398 IN denotes in
T6494 9399-9402 DT denotes the
T6496 9403-9409 JJ denotes tibial
T6495 9410-9415 NN denotes nerve
T6497 9416-9419 CC denotes but
T6498 9420-9425 EX denotes there
T6499 9426-9430 VBD denotes were
T6500 9431-9433 DT denotes no
T6502 9434-9438 NN denotes TrkC
T6504 9438-9439 HYPH denotes -
T6503 9439-9447 JJ denotes positive
T6501 9448-9453 NNS denotes axons
T6505 9453-9454 : denotes ;
T6506 9455-9457 IN denotes in
T6507 9458-9466 NN denotes contrast
T6508 9466-9468 , denotes ,
T6509 9468-9472 NN denotes TrkA
T6511 9472-9473 HYPH denotes -
T6512 9474-9477 CC denotes and
T6513 9478-9482 NN denotes TrkC
T6514 9482-9483 HYPH denotes -
T6510 9483-9490 VBN denotes labeled
T6515 9491-9496 NNS denotes axons
T6492 9497-9500 VBP denotes are
T6516 9501-9505 RB denotes both
T6517 9506-9513 JJ denotes present
T6518 9514-9516 IN denotes in
T6519 9517-9519 NN denotes WT
T6521 9519-9521 , denotes ,
T6522 9521-9524 NN denotes Bax
T6523 9525-9527 NN denotes KO
T6524 9527-9529 , denotes ,
T6525 9529-9532 CC denotes and
T6526 9533-9539 JJ denotes double
T6527 9540-9542 NN denotes KO
T6520 9543-9550 NNS denotes animals
T6528 9551-9552 -LRB- denotes (
T6530 9552-9558 NN denotes Figure
T6529 9559-9561 NN denotes 4F
T6531 9561-9562 -RRB- denotes )
T6532 9562-9563 . denotes .
T6533 9563-9744 sentence denotes These results suggest that although proprioceptive axons follow proper trajectories in distal peripheral nerves, they fail to innervate their target muscles in the absence of NT-3.
T6534 9564-9569 DT denotes These
T6535 9570-9577 NNS denotes results
T6536 9578-9585 VBP denotes suggest
T6537 9586-9590 IN denotes that
T6539 9591-9599 IN denotes although
T6541 9600-9614 JJ denotes proprioceptive
T6542 9615-9620 NNS denotes axons
T6540 9621-9627 VBP denotes follow
T6543 9628-9634 JJ denotes proper
T6544 9635-9647 NNS denotes trajectories
T6545 9648-9650 IN denotes in
T6546 9651-9657 JJ denotes distal
T6548 9658-9668 JJ denotes peripheral
T6547 9669-9675 NNS denotes nerves
T6549 9675-9677 , denotes ,
T6550 9677-9681 PRP denotes they
T6538 9682-9686 VBP denotes fail
T6551 9687-9689 TO denotes to
T6552 9690-9699 VB denotes innervate
T6553 9700-9705 PRP$ denotes their
T6555 9706-9712 NN denotes target
T6554 9713-9720 NNS denotes muscles
T6556 9721-9723 IN denotes in
T6557 9724-9727 DT denotes the
T6558 9728-9735 NN denotes absence
T6559 9736-9738 IN denotes of
T6560 9739-9741 NN denotes NT
T6561 9741-9742 HYPH denotes -
T6562 9742-9743 CD denotes 3
T6563 9743-9744 . denotes .
T7869 11001-11003 NN denotes NT
T7871 11003-11004 HYPH denotes -
T7872 11004-11005 CD denotes 3
T7870 11006-11008 VBZ denotes Is
T7873 11009-11010 DT denotes a
T7874 11011-11026 NN denotes Chemoattractant
T7875 11027-11030 IN denotes for
T7876 11031-11034 NN denotes DRG
T7877 11035-11040 NNS denotes Axons
T7878 11041-11043 FW denotes In
T7879 11044-11049 FW denotes Vitro
T7880 11049-11169 sentence denotes To test the hypothesis that NT-3 acts as a chemoattractant for sensory axons, we performed a series of in vitro assays.
T7881 11050-11052 TO denotes To
T7882 11053-11057 VB denotes test
T7884 11058-11061 DT denotes the
T7885 11062-11072 NN denotes hypothesis
T7886 11073-11077 IN denotes that
T7888 11078-11080 NN denotes NT
T7889 11080-11081 HYPH denotes -
T7890 11081-11082 CD denotes 3
T7887 11083-11087 VBZ denotes acts
T7891 11088-11090 IN denotes as
T7892 11091-11092 DT denotes a
T7893 11093-11108 NN denotes chemoattractant
T7894 11109-11112 IN denotes for
T7895 11113-11120 JJ denotes sensory
T7896 11121-11126 NNS denotes axons
T7897 11126-11128 , denotes ,
T7898 11128-11130 PRP denotes we
T7883 11131-11140 VBD denotes performed
T7899 11141-11142 DT denotes a
T7900 11143-11149 NN denotes series
T7901 11150-11152 IN denotes of
T7902 11153-11155 FW denotes in
T7903 11156-11161 FW denotes vitro
T7904 11162-11168 NNS denotes assays
T7905 11168-11169 . denotes .
T7906 11169-11352 sentence denotes Proprioceptive axons in mice enter the gray matter in the spinal cord and advance ventrally parallel to the midline by E13 and reach the motor neurons by E15 (Ozaki and Snider 1994).
T7907 11170-11184 JJ denotes Proprioceptive
T7908 11185-11190 NNS denotes axons
T7910 11191-11193 IN denotes in
T7911 11194-11198 NNS denotes mice
T7909 11199-11204 VBP denotes enter
T7912 11205-11208 DT denotes the
T7914 11209-11213 JJ denotes gray
T7913 11214-11220 NN denotes matter
T7915 11221-11223 IN denotes in
T7916 11224-11227 DT denotes the
T7918 11228-11234 JJ denotes spinal
T7917 11235-11239 NN denotes cord
T7919 11240-11243 CC denotes and
T7920 11244-11251 VBP denotes advance
T7921 11252-11261 RB denotes ventrally
T7922 11262-11270 RB denotes parallel
T7923 11271-11273 IN denotes to
T7924 11274-11277 DT denotes the
T7925 11278-11285 NN denotes midline
T7926 11286-11288 IN denotes by
T7927 11289-11292 NN denotes E13
T7928 11293-11296 CC denotes and
T7929 11297-11302 VBP denotes reach
T7930 11303-11306 DT denotes the
T7932 11307-11312 NN denotes motor
T7931 11313-11320 NNS denotes neurons
T7933 11321-11323 IN denotes by
T7934 11324-11327 NN denotes E15
T7935 11328-11329 -LRB- denotes (
T7936 11329-11334 NNP denotes Ozaki
T7937 11335-11338 CC denotes and
T7938 11339-11345 NNP denotes Snider
T7939 11346-11350 CD denotes 1994
T7940 11350-11351 -RRB- denotes )
T7941 11351-11352 . denotes .
T7942 11352-11448 sentence denotes We co-cultured collagen-embedded E13 WT DRG explants with NT-3-soaked sepharose beads (n = 26).
T7943 11353-11355 PRP denotes We
T7944 11356-11367 VBD denotes co-cultured
T7945 11368-11376 NN denotes collagen
T7947 11376-11377 HYPH denotes -
T7946 11377-11385 VBN denotes embedded
T7949 11386-11389 NN denotes E13
T7950 11390-11392 NN denotes WT
T7951 11393-11396 NN denotes DRG
T7948 11397-11405 NNS denotes explants
T7952 11406-11410 IN denotes with
T7953 11411-11413 NN denotes NT
T7955 11413-11414 HYPH denotes -
T7956 11414-11415 CD denotes 3
T7957 11415-11416 HYPH denotes -
T7954 11416-11422 VBN denotes soaked
T7959 11423-11432 NN denotes sepharose
T7958 11433-11438 NNS denotes beads
T7960 11439-11440 -LRB- denotes (
T7962 11440-11441 NN denotes n
T7963 11442-11443 SYM denotes =
T7961 11444-11446 CD denotes 26
T7964 11446-11447 -RRB- denotes )
T7965 11447-11448 . denotes .
T7966 11448-11567 sentence denotes Control cultures were set up using bovine serum albumin (BSA)– or phosphate buffer saline (PBS)–soaked beads (n = 12).
T7967 11449-11456 NN denotes Control
T7968 11457-11465 NNS denotes cultures
T7970 11466-11470 VBD denotes were
T7969 11471-11474 VBN denotes set
T7971 11475-11477 RP denotes up
T7972 11478-11483 VBG denotes using
T7973 11484-11490 JJ denotes bovine
T7975 11491-11496 NN denotes serum
T7974 11497-11504 NN denotes albumin
T7977 11505-11506 -LRB- denotes (
T7978 11506-11509 NN denotes BSA
T7979 11509-11510 -RRB- denotes )
T7980 11510-11511 -LRB- denotes –
T7981 11512-11514 CC denotes or
T7982 11515-11524 NN denotes phosphate
T7984 11525-11531 NN denotes buffer
T7983 11532-11538 NN denotes saline
T7985 11539-11540 -LRB- denotes (
T7986 11540-11543 NN denotes PBS
T7987 11543-11544 -RRB- denotes )
T7988 11544-11545 -RRB- denotes –
T7976 11545-11551 VBN denotes soaked
T7989 11552-11557 NNS denotes beads
T7990 11558-11559 -LRB- denotes (
T7992 11559-11560 NN denotes n
T7993 11561-11562 SYM denotes =
T7991 11563-11565 CD denotes 12
T7994 11565-11566 -RRB- denotes )
T7995 11566-11567 . denotes .
T7996 11567-11815 sentence denotes DRG axons began extending towards the localized NT-3 source by the end of the first day and consistently displayed a strong chemoattraction by 3 d in vitro, whereas they did not show such preference for BSA-loaded control beads (Figure 5A and 5B).
T7997 11568-11571 NN denotes DRG
T7998 11572-11577 NNS denotes axons
T7999 11578-11583 VBD denotes began
T8000 11584-11593 VBG denotes extending
T8001 11594-11601 IN denotes towards
T8002 11602-11605 DT denotes the
T8004 11606-11615 JJ denotes localized
T8005 11616-11618 NN denotes NT
T8006 11618-11619 HYPH denotes -
T8007 11619-11620 CD denotes 3
T8003 11621-11627 NN denotes source
T8008 11628-11630 IN denotes by
T8009 11631-11634 DT denotes the
T8010 11635-11638 NN denotes end
T8011 11639-11641 IN denotes of
T8012 11642-11645 DT denotes the
T8014 11646-11651 JJ denotes first
T8013 11652-11655 NN denotes day
T8015 11656-11659 CC denotes and
T8016 11660-11672 RB denotes consistently
T8017 11673-11682 VBD denotes displayed
T8018 11683-11684 DT denotes a
T8020 11685-11691 JJ denotes strong
T8019 11692-11707 NN denotes chemoattraction
T8021 11708-11710 IN denotes by
T8022 11711-11712 CD denotes 3
T8023 11713-11714 NN denotes d
T8024 11715-11717 FW denotes in
T8025 11718-11723 FW denotes vitro
T8026 11723-11725 , denotes ,
T8027 11725-11732 IN denotes whereas
T8029 11733-11737 PRP denotes they
T8030 11738-11741 VBD denotes did
T8031 11742-11745 RB denotes not
T8028 11746-11750 VB denotes show
T8032 11751-11755 JJ denotes such
T8033 11756-11766 NN denotes preference
T8034 11767-11770 IN denotes for
T8035 11771-11774 NN denotes BSA
T8037 11774-11775 HYPH denotes -
T8036 11775-11781 VBN denotes loaded
T8039 11782-11789 NN denotes control
T8038 11790-11795 NNS denotes beads
T8040 11796-11797 -LRB- denotes (
T8042 11797-11803 NN denotes Figure
T8041 11804-11806 NN denotes 5A
T8043 11807-11810 CC denotes and
T8044 11811-11813 NN denotes 5B
T8045 11813-11814 -RRB- denotes )
T8046 11814-11815 . denotes .
T8047 11815-11952 sentence denotes This attraction was not due to survival support of NT-3 because Bax null ganglia displayed the same chemoattraction (Figure 5C; n = 16).
T8048 11816-11820 DT denotes This
T8049 11821-11831 NN denotes attraction
T8050 11832-11835 VBD denotes was
T8051 11836-11839 RB denotes not
T8052 11840-11843 IN denotes due
T8053 11844-11846 IN denotes to
T8054 11847-11855 NN denotes survival
T8055 11856-11863 NN denotes support
T8056 11864-11866 IN denotes of
T8057 11867-11869 NN denotes NT
T8058 11869-11870 HYPH denotes -
T8059 11870-11871 CD denotes 3
T8060 11872-11879 IN denotes because
T8062 11880-11883 NN denotes Bax
T8063 11884-11888 JJ denotes null
T8064 11889-11896 NNS denotes ganglia
T8061 11897-11906 VBD denotes displayed
T8065 11907-11910 DT denotes the
T8067 11911-11915 JJ denotes same
T8066 11916-11931 NN denotes chemoattraction
T8068 11932-11933 -LRB- denotes (
T8070 11933-11939 NN denotes Figure
T8069 11940-11942 NN denotes 5C
T8071 11942-11943 : denotes ;
T8072 11944-11945 NN denotes n
T8074 11946-11947 SYM denotes =
T8073 11948-11950 CD denotes 16
T8075 11950-11951 -RRB- denotes )
T8076 11951-11952 . denotes .
T8077 11952-12001 sentence denotes NT-3 may act through either TrkC, or the p75NTR.
T8078 11953-11955 NN denotes NT
T8080 11955-11956 HYPH denotes -
T8081 11956-11957 CD denotes 3
T8082 11958-11961 MD denotes may
T8079 11962-11965 VB denotes act
T8083 11966-11973 IN denotes through
T8084 11974-11980 CC denotes either
T8085 11981-11985 NN denotes TrkC
T8086 11985-11987 , denotes ,
T8087 11987-11989 CC denotes or
T8088 11990-11993 DT denotes the
T8089 11994-12000 NN denotes p75NTR
T8090 12000-12001 . denotes .
T8091 12001-12096 sentence denotes We repeated the co-culture experiments with DRG explants derived from p75NTR KO mice (n = 18).
T8092 12002-12004 PRP denotes We
T8093 12005-12013 VBD denotes repeated
T8094 12014-12017 DT denotes the
T8096 12018-12028 NN denotes co-culture
T8095 12029-12040 NNS denotes experiments
T8097 12041-12045 IN denotes with
T8098 12046-12049 NN denotes DRG
T8099 12050-12058 NNS denotes explants
T8100 12059-12066 VBN denotes derived
T8101 12067-12071 IN denotes from
T8102 12072-12078 NN denotes p75NTR
T8103 12079-12081 NN denotes KO
T8104 12082-12086 NNS denotes mice
T8105 12087-12088 -LRB- denotes (
T8107 12088-12089 NN denotes n
T8108 12090-12091 SYM denotes =
T8106 12092-12094 CD denotes 18
T8109 12094-12095 -RRB- denotes )
T8110 12095-12096 . denotes .
T8111 12096-12190 sentence denotes Axons of these ganglia also showed strong chemoattraction towards the NT-3 beads (Figure 5D).
T8112 12097-12102 NNS denotes Axons
T8114 12103-12105 IN denotes of
T8115 12106-12111 DT denotes these
T8116 12112-12119 NNS denotes ganglia
T8117 12120-12124 RB denotes also
T8113 12125-12131 VBD denotes showed
T8118 12132-12138 JJ denotes strong
T8119 12139-12154 NN denotes chemoattraction
T8120 12155-12162 IN denotes towards
T8121 12163-12166 DT denotes the
T8123 12167-12169 NN denotes NT
T8124 12169-12170 HYPH denotes -
T8125 12170-12171 CD denotes 3
T8122 12172-12177 NNS denotes beads
T8126 12178-12179 -LRB- denotes (
T8128 12179-12185 NN denotes Figure
T8127 12186-12188 NN denotes 5D
T8129 12188-12189 -RRB- denotes )
T8130 12189-12190 . denotes .
T8131 12190-12366 sentence denotes Finally, we used diffusible TrkC receptors conjugated to IgG constant regions (TrkC-Fc) added to the medium (n = 6) to deplete soluble NT-3 from the collagen gels (Figure 5E).
T8132 12191-12198 RB denotes Finally
T8134 12198-12200 , denotes ,
T8135 12200-12202 PRP denotes we
T8133 12203-12207 VBD denotes used
T8136 12208-12218 JJ denotes diffusible
T8138 12219-12223 NN denotes TrkC
T8137 12224-12233 NNS denotes receptors
T8139 12234-12244 VBN denotes conjugated
T8140 12245-12247 IN denotes to
T8141 12248-12251 NN denotes IgG
T8143 12252-12260 NN denotes constant
T8142 12261-12268 NNS denotes regions
T8144 12269-12270 -LRB- denotes (
T8146 12270-12274 NN denotes TrkC
T8147 12274-12275 HYPH denotes -
T8145 12275-12277 NN denotes Fc
T8148 12277-12278 -RRB- denotes )
T8149 12279-12284 VBN denotes added
T8150 12285-12287 IN denotes to
T8151 12288-12291 DT denotes the
T8152 12292-12298 NN denotes medium
T8153 12299-12300 -LRB- denotes (
T8155 12300-12301 NN denotes n
T8156 12302-12303 SYM denotes =
T8154 12304-12305 CD denotes 6
T8157 12305-12306 -RRB- denotes )
T8158 12307-12309 TO denotes to
T8159 12310-12317 VB denotes deplete
T8160 12318-12325 JJ denotes soluble
T8161 12326-12328 NN denotes NT
T8162 12328-12329 HYPH denotes -
T8163 12329-12330 CD denotes 3
T8164 12331-12335 IN denotes from
T8165 12336-12339 DT denotes the
T8167 12340-12348 NN denotes collagen
T8166 12349-12353 NNS denotes gels
T8168 12354-12355 -LRB- denotes (
T8170 12355-12361 NN denotes Figure
T8169 12362-12364 NN denotes 5E
T8171 12364-12365 -RRB- denotes )
T8172 12365-12366 . denotes .
T8173 12366-12496 sentence denotes In the presence of TrkC-Fc the chemoattraction was completely blocked, demonstrating that the effect we see is specific for NT-3.
T8174 12367-12369 IN denotes In
T8176 12370-12373 DT denotes the
T8177 12374-12382 NN denotes presence
T8178 12383-12385 IN denotes of
T8179 12386-12390 NN denotes TrkC
T8181 12390-12391 HYPH denotes -
T8180 12391-12393 NN denotes Fc
T8182 12394-12397 DT denotes the
T8183 12398-12413 NN denotes chemoattraction
T8184 12414-12417 VBD denotes was
T8185 12418-12428 RB denotes completely
T8175 12429-12436 VBN denotes blocked
T8186 12436-12438 , denotes ,
T8187 12438-12451 VBG denotes demonstrating
T8188 12452-12456 IN denotes that
T8190 12457-12460 DT denotes the
T8191 12461-12467 NN denotes effect
T8192 12468-12470 PRP denotes we
T8193 12471-12474 VBP denotes see
T8189 12475-12477 VBZ denotes is
T8194 12478-12486 JJ denotes specific
T8195 12487-12490 IN denotes for
T8196 12491-12493 NN denotes NT
T8197 12493-12494 HYPH denotes -
T8198 12494-12495 CD denotes 3
T8199 12495-12496 . denotes .
T8200 12496-12686 sentence denotes In order to investigate the active range of our beads, we have repeated the cultures with WT E13 DRGs by placing the beads at increasing distances from the ganglia (n = 4 each) (Figure 5F).
T8201 12497-12499 IN denotes In
T8203 12500-12505 NN denotes order
T8204 12506-12508 TO denotes to
T8205 12509-12520 VB denotes investigate
T8206 12521-12524 DT denotes the
T8208 12525-12531 JJ denotes active
T8207 12532-12537 NN denotes range
T8209 12538-12540 IN denotes of
T8210 12541-12544 PRP$ denotes our
T8211 12545-12550 NNS denotes beads
T8212 12550-12552 , denotes ,
T8213 12552-12554 PRP denotes we
T8214 12555-12559 VBP denotes have
T8202 12560-12568 VBN denotes repeated
T8215 12569-12572 DT denotes the
T8216 12573-12581 NNS denotes cultures
T8217 12582-12586 IN denotes with
T8218 12587-12589 NN denotes WT
T8220 12590-12593 NN denotes E13
T8219 12594-12598 NNS denotes DRGs
T8221 12599-12601 IN denotes by
T8222 12602-12609 VBG denotes placing
T8223 12610-12613 DT denotes the
T8224 12614-12619 NNS denotes beads
T8225 12620-12622 IN denotes at
T8226 12623-12633 VBG denotes increasing
T8227 12634-12643 NNS denotes distances
T8228 12644-12648 IN denotes from
T8229 12649-12652 DT denotes the
T8230 12653-12660 NNS denotes ganglia
T8231 12661-12662 -LRB- denotes (
T8233 12662-12663 NN denotes n
T8234 12664-12665 SYM denotes =
T8232 12666-12667 CD denotes 4
T8235 12668-12672 DT denotes each
T8236 12672-12673 -RRB- denotes )
T8237 12674-12675 -LRB- denotes (
T8239 12675-12681 NN denotes Figure
T8238 12682-12684 NN denotes 5F
T8240 12684-12685 -RRB- denotes )
T8241 12685-12686 . denotes .
T8242 12686-12852 sentence denotes There was still preferred growth towards the bead at 1,200μm, the longest distance studied, although the number of axons and the extent of growth were not as robust.
T8243 12687-12692 EX denotes There
T8244 12693-12696 VBD denotes was
T8245 12697-12702 RB denotes still
T8246 12703-12712 JJ denotes preferred
T8247 12713-12719 NN denotes growth
T8248 12720-12727 IN denotes towards
T8249 12728-12731 DT denotes the
T8250 12732-12736 NN denotes bead
T8251 12737-12739 IN denotes at
T8252 12740-12745 CD denotes 1,200
T8253 12745-12747 NN denotes μm
T8254 12747-12749 , denotes ,
T8255 12749-12752 DT denotes the
T8257 12753-12760 JJS denotes longest
T8256 12761-12769 NN denotes distance
T8258 12770-12777 VBN denotes studied
T8259 12777-12779 , denotes ,
T8260 12779-12787 IN denotes although
T8262 12788-12791 DT denotes the
T8263 12792-12798 NN denotes number
T8264 12799-12801 IN denotes of
T8265 12802-12807 NNS denotes axons
T8266 12808-12811 CC denotes and
T8267 12812-12815 DT denotes the
T8268 12816-12822 NN denotes extent
T8269 12823-12825 IN denotes of
T8270 12826-12832 NN denotes growth
T8261 12833-12837 VBD denotes were
T8271 12838-12841 RB denotes not
T8272 12842-12844 RB denotes as
T8273 12845-12851 JJ denotes robust
T8274 12851-12852 . denotes .
T8275 12852-13012 sentence denotes Next, we set up E13 DRG spinal cord explant cultures using NT-3-loaded beads placed at the midline at mid-spinal cord level as an ectopic NT-3 source (n = 15).
T8276 12853-12857 RB denotes Next
T8278 12857-12859 , denotes ,
T8279 12859-12861 PRP denotes we
T8277 12862-12865 VBD denotes set
T8280 12866-12868 RP denotes up
T8281 12869-12872 NN denotes E13
T8283 12873-12876 NN denotes DRG
T8284 12877-12883 JJ denotes spinal
T8285 12884-12888 NN denotes cord
T8286 12889-12896 NN denotes explant
T8282 12897-12905 NNS denotes cultures
T8287 12906-12911 VBG denotes using
T8288 12912-12914 NN denotes NT
T8290 12914-12915 HYPH denotes -
T8291 12915-12916 CD denotes 3
T8292 12916-12917 HYPH denotes -
T8289 12917-12923 VBN denotes loaded
T8293 12924-12929 NNS denotes beads
T8294 12930-12936 VBN denotes placed
T8295 12937-12939 IN denotes at
T8296 12940-12943 DT denotes the
T8297 12944-12951 NN denotes midline
T8298 12952-12954 IN denotes at
T8299 12955-12965 JJ denotes mid-spinal
T8301 12966-12970 NN denotes cord
T8300 12971-12976 NN denotes level
T8302 12977-12979 IN denotes as
T8303 12980-12982 DT denotes an
T8305 12983-12990 JJ denotes ectopic
T8306 12991-12993 NN denotes NT
T8307 12993-12994 HYPH denotes -
T8308 12994-12995 CD denotes 3
T8304 12996-13002 NN denotes source
T8309 13003-13004 -LRB- denotes (
T8311 13004-13005 NN denotes n
T8312 13006-13007 SYM denotes =
T8310 13008-13010 CD denotes 15
T8313 13010-13011 -RRB- denotes )
T8314 13011-13012 . denotes .
T8315 13012-13070 sentence denotes Control cultures were set using PBS-loaded beads (n = 6).
T8316 13013-13020 NN denotes Control
T8317 13021-13029 NNS denotes cultures
T8319 13030-13034 VBD denotes were
T8318 13035-13038 VBN denotes set
T8320 13039-13044 VBG denotes using
T8321 13045-13048 NN denotes PBS
T8323 13048-13049 HYPH denotes -
T8322 13049-13055 VBN denotes loaded
T8324 13056-13061 NNS denotes beads
T8325 13062-13063 -LRB- denotes (
T8327 13063-13064 NN denotes n
T8328 13065-13066 SYM denotes =
T8326 13067-13068 CD denotes 6
T8329 13068-13069 -RRB- denotes )
T8330 13069-13070 . denotes .
T8331 13070-13287 sentence denotes DiI labeling through the DRGs revealed numerous fibers entering the spinal cord at ectopic regions and growing towards the NT-3 beads (Figure 6A), surrounding the beads and forming bundles around them (Figure 6C–6E).
T8332 13071-13074 NN denotes DiI
T8333 13075-13083 NN denotes labeling
T8335 13084-13091 IN denotes through
T8336 13092-13095 DT denotes the
T8337 13096-13100 NNS denotes DRGs
T8334 13101-13109 VBD denotes revealed
T8338 13110-13118 JJ denotes numerous
T8339 13119-13125 NNS denotes fibers
T8340 13126-13134 VBG denotes entering
T8341 13135-13138 DT denotes the
T8343 13139-13145 JJ denotes spinal
T8342 13146-13150 NN denotes cord
T8344 13151-13153 IN denotes at
T8345 13154-13161 JJ denotes ectopic
T8346 13162-13169 NNS denotes regions
T8347 13170-13173 CC denotes and
T8348 13174-13181 VBG denotes growing
T8349 13182-13189 IN denotes towards
T8350 13190-13193 DT denotes the
T8352 13194-13196 NN denotes NT
T8353 13196-13197 HYPH denotes -
T8354 13197-13198 CD denotes 3
T8351 13199-13204 NNS denotes beads
T8355 13205-13206 -LRB- denotes (
T8357 13206-13212 NN denotes Figure
T8356 13213-13215 NN denotes 6A
T8358 13215-13216 -RRB- denotes )
T8359 13216-13218 , denotes ,
T8360 13218-13229 VBG denotes surrounding
T8361 13230-13233 DT denotes the
T8362 13234-13239 NNS denotes beads
T8363 13240-13243 CC denotes and
T8364 13244-13251 VBG denotes forming
T8365 13252-13259 NNS denotes bundles
T8366 13260-13266 IN denotes around
T8367 13267-13271 PRP denotes them
T8368 13272-13273 -LRB- denotes (
T8370 13273-13279 NN denotes Figure
T8369 13280-13282 NN denotes 6C
T8371 13282-13283 SYM denotes –
T8372 13283-13285 NN denotes 6E
T8373 13285-13286 -RRB- denotes )
T8374 13286-13287 . denotes .
T8375 13287-13456 sentence denotes In control cultures, all labeled fibers were directed towards the dorsal spinal cord and terminated there, where they normally enter the gray matter at E13 (Figure 6B).
T8376 13288-13290 IN denotes In
T8378 13291-13298 NN denotes control
T8379 13299-13307 NNS denotes cultures
T8380 13307-13309 , denotes ,
T8381 13309-13312 DT denotes all
T8383 13313-13320 VBN denotes labeled
T8382 13321-13327 NNS denotes fibers
T8384 13328-13332 VBD denotes were
T8377 13333-13341 VBN denotes directed
T8385 13342-13349 IN denotes towards
T8386 13350-13353 DT denotes the
T8388 13354-13360 JJ denotes dorsal
T8389 13361-13367 JJ denotes spinal
T8387 13368-13372 NN denotes cord
T8390 13373-13376 CC denotes and
T8391 13377-13387 VBN denotes terminated
T8392 13388-13393 RB denotes there
T8393 13393-13395 , denotes ,
T8394 13395-13400 WRB denotes where
T8396 13401-13405 PRP denotes they
T8397 13406-13414 RB denotes normally
T8395 13415-13420 VBP denotes enter
T8398 13421-13424 DT denotes the
T8400 13425-13429 JJ denotes gray
T8399 13430-13436 NN denotes matter
T8401 13437-13439 IN denotes at
T8402 13440-13443 NN denotes E13
T8403 13444-13445 -LRB- denotes (
T8405 13445-13451 NN denotes Figure
T8404 13452-13454 NN denotes 6B
T8406 13454-13455 -RRB- denotes )
T8407 13455-13456 . denotes .
T8408 13456-13528 sentence denotes No axons were observed around the PBS-loaded control beads (Figure 6F).
T8409 13457-13459 DT denotes No
T8410 13460-13465 NNS denotes axons
T8412 13466-13470 VBD denotes were
T8411 13471-13479 VBN denotes observed
T8413 13480-13486 IN denotes around
T8414 13487-13490 DT denotes the
T8416 13491-13494 NN denotes PBS
T8418 13494-13495 HYPH denotes -
T8417 13495-13501 VBN denotes loaded
T8419 13502-13509 NN denotes control
T8415 13510-13515 NNS denotes beads
T8420 13516-13517 -LRB- denotes (
T8422 13517-13523 NN denotes Figure
T8421 13524-13526 NN denotes 6F
T8423 13526-13527 -RRB- denotes )
T8424 13527-13528 . denotes .
T8425 13528-13814 sentence denotes Axons that normally enter the gray matter through dorsal spinal cord grow towards the midline when presented with a localized NT-3 source, and new axon growth towards the NT-3 bead is initiated from DRGs, entering the spinal cord at ectopic loci at lateral mid-spinal cord (Figure 6G).
T8426 13529-13534 NNS denotes Axons
T8428 13535-13539 WDT denotes that
T8430 13540-13548 RB denotes normally
T8429 13549-13554 VBP denotes enter
T8431 13555-13558 DT denotes the
T8433 13559-13563 JJ denotes gray
T8432 13564-13570 NN denotes matter
T8434 13571-13578 IN denotes through
T8435 13579-13585 JJ denotes dorsal
T8437 13586-13592 JJ denotes spinal
T8436 13593-13597 NN denotes cord
T8427 13598-13602 VBP denotes grow
T8438 13603-13610 IN denotes towards
T8439 13611-13614 DT denotes the
T8440 13615-13622 NN denotes midline
T8441 13623-13627 WRB denotes when
T8442 13628-13637 VBN denotes presented
T8443 13638-13642 IN denotes with
T8444 13643-13644 DT denotes a
T8446 13645-13654 JJ denotes localized
T8447 13655-13657 NN denotes NT
T8448 13657-13658 HYPH denotes -
T8449 13658-13659 CD denotes 3
T8445 13660-13666 NN denotes source
T8450 13666-13668 , denotes ,
T8451 13668-13671 CC denotes and
T8452 13672-13675 JJ denotes new
T8454 13676-13680 NN denotes axon
T8453 13681-13687 NN denotes growth
T8456 13688-13695 IN denotes towards
T8457 13696-13699 DT denotes the
T8459 13700-13702 NN denotes NT
T8460 13702-13703 HYPH denotes -
T8461 13703-13704 CD denotes 3
T8458 13705-13709 NN denotes bead
T8462 13710-13712 VBZ denotes is
T8455 13713-13722 VBN denotes initiated
T8463 13723-13727 IN denotes from
T8464 13728-13732 NNS denotes DRGs
T8465 13732-13734 , denotes ,
T8466 13734-13742 VBG denotes entering
T8467 13743-13746 DT denotes the
T8469 13747-13753 JJ denotes spinal
T8468 13754-13758 NN denotes cord
T8470 13759-13761 IN denotes at
T8471 13762-13769 JJ denotes ectopic
T8472 13770-13774 NNS denotes loci
T8473 13775-13777 IN denotes at
T8474 13778-13785 JJ denotes lateral
T8476 13786-13796 JJ denotes mid-spinal
T8475 13797-13801 NN denotes cord
T8477 13802-13803 -LRB- denotes (
T8479 13803-13809 NN denotes Figure
T8478 13810-13812 NN denotes 6G
T8480 13812-13813 -RRB- denotes )
T8481 13813-13814 . denotes .
T8482 13814-13886 sentence denotes NT-3 is therefore capable of acting as a chemoattractant for DRG axons.
T8483 13815-13817 NN denotes NT
T8485 13817-13818 HYPH denotes -
T8486 13818-13819 CD denotes 3
T8484 13820-13822 VBZ denotes is
T8487 13823-13832 RB denotes therefore
T8488 13833-13840 JJ denotes capable
T8489 13841-13843 IN denotes of
T8490 13844-13850 VBG denotes acting
T8491 13851-13853 IN denotes as
T8492 13854-13855 DT denotes a
T8493 13856-13871 NN denotes chemoattractant
T8494 13872-13875 IN denotes for
T8495 13876-13879 NN denotes DRG
T8496 13880-13885 NNS denotes axons
T8497 13885-13886 . denotes .
R1000 T4198 T4196 prep to,confined
R1001 T4199 T4200 amod dorsal,cord
R1002 T4200 T4198 pobj cord,to
R1003 T4201 T4200 amod spinal,cord
R1004 T4202 T4200 prep in,cord
R1005 T4203 T4204 nmod NT,KOs
R1006 T4204 T4202 pobj KOs,in
R1007 T4205 T4203 punct -,NT
R1008 T4206 T4203 nummod 3,NT
R1009 T4207 T4208 punct (,2A
R1010 T4208 T4196 parataxis 2A,confined
R1011 T4209 T4208 compound Figure,2A
R1012 T4210 T4208 punct ),2A
R1013 T4211 T4196 punct ", ",confined
R1014 T4212 T4213 mark as,reported
R1015 T4213 T4196 advcl reported,confined
R1016 T4214 T4213 advmod earlier,reported
R1017 T4215 T4196 punct ", ",confined
R1018 T4216 T4196 advcl consistent,confined
R1019 T4217 T4216 prep with,consistent
R1020 T4218 T4219 det a,absence
R1021 T4219 T4217 pobj absence,with
R1022 T4220 T4219 amod complete,absence
R1023 T4221 T4219 prep of,absence
R1024 T4222 T4223 amod proprioceptive,innervation
R1025 T4223 T4221 pobj innervation,of
R1026 T4224 T4225 punct (,Ernfors
R1027 T4225 T4216 meta Ernfors,consistent
R1028 T4226 T4225 nmod et,Ernfors
R1029 T4227 T4225 nmod al.,Ernfors
R1030 T4228 T4225 nummod 1994,Ernfors
R1031 T4229 T4225 punct ;,Ernfors
R1032 T4230 T4225 nmod Tessarollo,Ernfors
R1033 T4231 T4225 nmod et,Ernfors
R1034 T4232 T4225 nmod al.,Ernfors
R1035 T4233 T4225 nummod 1994,Ernfors
R1036 T4234 T4225 punct ),Ernfors
R1037 T4235 T4196 punct .,confined
R1038 T4237 T4238 prep In,followed
R1039 T4239 T4240 amod double,KOs
R1040 T4240 T4237 pobj KOs,In
R1041 T4241 T4238 punct ", ",followed
R1042 T4242 T4243 amod proprioceptive,afferents
R1043 T4243 T4238 nsubj afferents,followed
R1044 T4244 T4238 advmod initially,followed
R1045 T4245 T4246 det a,trajectory
R1046 T4246 T4238 dobj trajectory,followed
R1047 T4247 T4246 amod similar,trajectory
R1048 T4248 T4247 prep to,similar
R1049 T4249 T4248 pobj that,to
R1050 T4250 T4249 prep of,that
R1051 T4251 T4252 compound WT,counterparts
R1052 T4252 T4250 pobj counterparts,of
R1053 T4253 T4238 punct ", ",followed
R1054 T4254 T4238 cc but,followed
R1055 T4255 T4256 nsubj most,failed
R1056 T4256 T4238 conj failed,followed
R1057 T4257 T4255 prep of,most
R1058 T4258 T4257 pobj them,of
R1059 T4259 T4260 aux to,project
R1060 T4260 T4256 xcomp project,failed
R1061 T4261 T4262 predet all,way
R1062 T4262 T4264 npadvmod way,to
R1063 T4263 T4262 det the,way
R1064 T4264 T4260 prep to,project
R1065 T4265 T4266 det the,cord
R1066 T4266 T4264 pobj cord,to
R1067 T4267 T4266 amod ventral,cord
R1068 T4268 T4264 cc and,to
R1069 T4269 T4264 conj into,to
R1070 T4270 T4271 det the,column
R1071 T4271 T4269 pobj column,into
R1072 T4272 T4271 amod lateral,column
R1073 T4273 T4271 compound motor,column
R1074 T4274 T4256 punct .,failed
R1075 T4276 T4277 advmod Instead,arborized
R1076 T4277 T4280 ccomp arborized,crossed
R1077 T4278 T4277 punct ", ",arborized
R1078 T4279 T4277 nsubj they,arborized
R1079 T4281 T4277 prep near,arborized
R1080 T4282 T4283 det the,midline
R1081 T4283 T4281 pobj midline,near
R1082 T4284 T4283 amod ventral,midline
R1083 T4285 T4280 punct ;,crossed
R1084 T4286 T4280 nsubj some,crossed
R1085 T4287 T4288 det the,midline
R1086 T4288 T4280 dobj midline,crossed
R1087 T4289 T4280 cc and,crossed
R1088 T4290 T4280 conj extended,crossed
R1089 T4291 T4290 prep into,extended
R1090 T4292 T4293 det the,cord
R1091 T4293 T4291 pobj cord,into
R1092 T4294 T4293 amod contralateral,cord
R1093 T4295 T4293 amod ventral,cord
R1094 T4296 T4297 punct (,2A
R1095 T4297 T4290 parataxis 2A,extended
R1096 T4298 T4297 compound Figure,2A
R1097 T4299 T4297 cc and,2A
R1098 T4300 T4297 conj 2C,2A
R1099 T4301 T4297 punct ),2A
R1100 T4302 T4280 punct .,crossed
R1101 T4304 T4305 prep In,repeated
R1102 T4306 T4304 pobj order,In
R1103 T4307 T4308 aux to,distinguish
R1104 T4308 T4306 acl distinguish,order
R1105 T4309 T4308 prep between,distinguish
R1106 T4310 T4311 det a,role
R1107 T4311 T4309 pobj role,between
R1108 T4312 T4311 prep for,role
R1109 T4313 T4312 pobj NT,for
R1110 T4314 T4313 punct -,NT
R1111 T4315 T4313 nummod 3,NT
R1112 T4316 T4311 prep in,role
R1113 T4317 T4316 pobj initiation,in
R1114 T4318 T4317 prep of,initiation
R1115 T4319 T4320 compound motor,neuron
R1116 T4320 T4321 compound neuron,innervation
R1117 T4321 T4318 pobj innervation,of
R1118 T4322 T4311 cc and,role
R1119 T4323 T4324 det a,role
R1120 T4324 T4311 conj role,role
R1121 T4325 T4324 prep for,role
R1122 T4326 T4325 pobj maintenance,for
R1123 T4327 T4305 punct ", ",repeated
R1124 T4328 T4305 nsubj we,repeated
R1125 T4329 T4330 det the,labeling
R1126 T4330 T4305 dobj labeling,repeated
R1127 T4331 T4330 compound DiI,labeling
R1128 T4332 T4305 prep at,repeated
R1129 T4333 T4332 pobj E17,at
R1130 T4334 T4305 punct .,repeated
R1131 T4336 T4337 compound Innervation,patterns
R1132 T4337 T4338 nsubj patterns,were
R1133 T4339 T4337 prep of,patterns
R1134 T4340 T4341 nmod E17,cords
R1135 T4341 T4339 pobj cords,of
R1136 T4342 T4341 amod spinal,cords
R1137 T4343 T4344 punct (,Figure
R1138 T4344 T4337 parataxis Figure,patterns
R1139 T4345 T4344 nummod 3,Figure
R1140 T4346 T4344 punct ),Figure
R1141 T4347 T4338 acomp similar,were
R1142 T4348 T4347 prep to,similar
R1143 T4349 T4348 pobj those,to
R1144 T4350 T4349 prep at,those
R1145 T4351 T4350 pobj P0,at
R1146 T4352 T4353 punct (,Figure
R1147 T4353 T4349 parataxis Figure,those
R1148 T4354 T4353 nummod 2,Figure
R1149 T4355 T4353 punct ),Figure
R1150 T4356 T4338 punct .,were
R1151 T4358 T4359 amod Dorsal,horns
R1152 T4359 T4360 nsubjpass horns,filled
R1153 T4361 T4359 prep of,horns
R1154 T4362 T4363 det all,genotypes
R1155 T4363 T4361 pobj genotypes,of
R1156 T4364 T4360 auxpass were,filled
R1157 T4365 T4360 agent with,filled
R1158 T4366 T4367 npadvmod DiI,labeled
R1159 T4367 T4369 amod labeled,fibers
R1160 T4368 T4367 punct -,labeled
R1161 T4369 T4365 pobj fibers,with
R1162 T4370 T4369 acl corresponding,fibers
R1163 T4371 T4370 prep to,corresponding
R1164 T4372 T4373 compound nerve,factor
R1165 T4373 T4375 npadvmod factor,dependent
R1166 T4374 T4373 compound growth,factor
R1167 T4375 T4377 amod dependent,axons
R1168 T4376 T4375 punct –,dependent
R1169 T4377 T4371 pobj axons,to
R1170 T4378 T4377 amod nociceptive,axons
R1171 T4379 T4360 punct .,filled
R1172 T4381 T4382 prep In,extended
R1173 T4383 T4384 nmod WT,embryos
R1174 T4384 T4381 pobj embryos,In
R1175 T4385 T4383 cc and,WT
R1176 T4386 T4387 compound Bax,KO
R1177 T4387 T4383 conj KO,WT
R1178 T4388 T4382 punct ", ",extended
R1179 T4389 T4390 amod proprioceptive,fibers
R1180 T4390 T4382 nsubj fibers,extended
R1181 T4391 T4382 prep towards,extended
R1182 T4392 T4393 amod ventral,horn
R1183 T4393 T4394 compound horn,neurons
R1184 T4394 T4391 pobj neurons,towards
R1185 T4395 T4394 compound motor,neurons
R1186 T4396 T4397 punct (,3A
R1187 T4397 T4394 parataxis 3A,neurons
R1188 T4398 T4397 compound Figure,3A
R1189 T4399 T4397 cc and,3A
R1190 T4400 T4397 conj 3B,3A
R1191 T4401 T4397 punct ),3A
R1192 T4402 T4382 punct ", ",extended
R1193 T4403 T4404 mark whereas,were
R1194 T4404 T4382 advcl were,extended
R1195 T4405 T4406 det the,horns
R1196 T4406 T4404 nsubj horns,were
R1197 T4407 T4406 amod ventral,horns
R1198 T4408 T4406 prep of,horns
R1199 T4409 T4410 det the,embryos
R1200 T4410 T4408 pobj embryos,of
R1201 T4411 T4412 nmod NT,KO
R1202 T4412 T4410 compound KO,embryos
R1203 T4413 T4411 punct -,NT
R1204 T4414 T4411 nummod 3,NT
R1205 T4415 T4404 acomp devoid,were
R1206 T4416 T4415 prep of,devoid
R1207 T4417 T4416 pobj innervation,of
R1208 T4418 T4419 punct (,3C
R1209 T4419 T4404 parataxis 3C,were
R1210 T4420 T4419 compound Figure,3C
R1211 T4421 T4419 punct ),3C
R1212 T4422 T4382 punct .,extended
R1213 T4424 T4425 prep In,entered
R1214 T4426 T4427 det the,KOs
R1215 T4427 T4424 pobj KOs,In
R1216 T4428 T4427 nmod Bax,KOs
R1217 T4429 T4428 punct /,Bax
R1218 T4430 T4428 appos NT,Bax
R1219 T4431 T4430 punct -,NT
R1220 T4432 T4430 nummod 3,NT
R1221 T4433 T4427 amod double,KOs
R1222 T4434 T4425 punct ", ",entered
R1223 T4435 T4436 npadvmod DiI,labeled
R1224 T4436 T4438 amod labeled,fibers
R1225 T4437 T4436 punct -,labeled
R1226 T4438 T4425 nsubj fibers,entered
R1227 T4439 T4440 det the,cord
R1228 T4440 T4425 dobj cord,entered
R1229 T4441 T4440 amod ventral,cord
R1230 T4442 T4440 amod spinal,cord
R1231 T4443 T4425 punct ", ",entered
R1232 T4444 T4425 cc but,entered
R1233 T4445 T4425 conj extended,entered
R1234 T4446 T4445 prep towards,extended
R1235 T4447 T4448 det the,midline
R1236 T4448 T4446 pobj midline,towards
R1237 T4449 T4450 advmod instead,of
R1238 T4450 T4448 cc of,midline
R1239 T4451 T4452 det the,horn
R1240 T4452 T4448 conj horn,midline
R1241 T4453 T4452 amod ventral,horn
R1242 T4454 T4455 punct (,3D
R1243 T4455 T4445 parataxis 3D,extended
R1244 T4456 T4455 compound Figure,3D
R1245 T4457 T4455 punct ),3D
R1246 T4458 T4445 punct ", ",extended
R1247 T4459 T4445 prep in,extended
R1248 T4460 T4461 det a,pattern
R1249 T4461 T4459 pobj pattern,in
R1250 T4542 T4543 det the,absence
R1251 T4462 T4461 amod similar,pattern
R1252 T4543 T4541 pobj absence,in
R1253 T4463 T4462 prep to,similar
R1254 T4544 T4543 prep of,absence
R1255 T4545 T4544 pobj NT,of
R1256 T4546 T4545 punct -,NT
R1257 T4464 T4463 pobj that,to
R1258 T4547 T4545 nummod 3,NT
R1259 T4548 T4549 det a,requirement
R1260 T4465 T4464 acl observed,that
R1261 T4549 T4531 dobj requirement,suggests
R1262 T4550 T4549 prep for,requirement
R1263 T4551 T4550 pobj NT,for
R1264 T4466 T4465 prep at,observed
R1265 T4552 T4551 punct -,NT
R1266 T4553 T4551 nummod 3,NT
R1267 T4467 T4466 pobj P0,at
R1268 T4554 T4549 prep for,requirement
R1269 T4555 T4556 amod proper,axon
R1270 T4468 T4425 punct .,entered
R1271 T4556 T4554 pobj axon,for
R1272 T4557 T4556 amod targeting,axon
R1273 T4470 T4471 poss Our,data
R1274 T4558 T4549 prep in,requirement
R1275 T4559 T4558 pobj addition,in
R1276 T4560 T4559 prep to,addition
R1277 T4561 T4562 det a,role
R1278 T4471 T4472 nsubj data,point
R1279 T4562 T4560 pobj role,to
R1280 T4563 T4562 prep in,role
R1281 T4473 T4472 prep to,point
R1282 T4564 T4565 amod sensory,axon
R1283 T4565 T4566 compound axon,maintenance
R1284 T4566 T4563 pobj maintenance,in
R1285 T4474 T4475 det a,absence
R1286 T4567 T4531 punct .,suggests
R1287 T4475 T4473 pobj absence,to
R1288 T4476 T4475 amod complete,absence
R1289 T4477 T4475 prep of,absence
R1290 T4478 T4479 amod proprioceptive,innervation
R1291 T4479 T4477 pobj innervation,of
R1292 T4480 T4479 prep of,innervation
R1293 T4481 T4482 det the,horn
R1294 T4482 T4480 pobj horn,of
R1295 T4483 T4482 amod ventral,horn
R1296 T4484 T4482 prep of,horn
R1297 T4485 T4486 det the,cord
R1298 T4486 T4484 pobj cord,of
R1299 T4487 T4488 npadvmod Bax,null
R1300 T4488 T4486 amod null,cord
R1301 T4489 T4487 punct /,Bax
R1302 T4490 T4487 appos NT,Bax
R1303 T4491 T4490 punct -,NT
R1304 T4492 T4490 nummod 3,NT
R1305 T4493 T4486 amod spinal,cord
R1306 T4494 T4475 prep throughout,absence
R1307 T4495 T4496 det the,stages
R1308 T4496 T4494 pobj stages,throughout
R1309 T4497 T4496 amod developmental,stages
R1310 T4498 T4496 acl investigated,stages
R1311 T4499 T4472 punct .,point
R1312 T4501 T4502 mark As,reach
R1313 T4502 T4507 advcl reach,established
R1314 T4503 T4504 det the,axons
R1315 T4504 T4502 nsubj axons,reach
R1316 T4505 T4504 amod sensory,axons
R1317 T4506 T4502 neg never,reach
R1318 T4508 T4509 compound motor,neuron
R1319 T4509 T4510 compound neuron,dendrites
R1320 T4510 T4502 dobj dendrites,reach
R1321 T4511 T4510 prep in,dendrites
R1322 T4512 T4513 det the,horn
R1323 T4513 T4511 pobj horn,in
R1324 T4514 T4513 amod ventral,horn
R1325 T4515 T4516 punct (,S1
R1326 T4516 T4502 parataxis S1,reach
R1327 T4517 T4516 compound Figure,S1
R1328 T4518 T4516 punct ),S1
R1329 T4519 T4507 punct ", ",established
R1330 T4520 T4521 det the,circuit
R1331 T4521 T4507 nsubjpass circuit,established
R1332 T4522 T4523 compound stretch,reflex
R1333 T4523 T4521 compound reflex,circuit
R1334 T4524 T4521 compound arc,circuit
R1335 T4525 T4507 auxpass is,established
R1336 T4526 T4507 neg not,established
R1337 T4527 T4507 punct .,established
R1338 T4529 T4530 det The,failure
R1339 T4530 T4531 nsubj failure,suggests
R1340 T4532 T4533 aux to,initiate
R1341 T4533 T4530 acl initiate,failure
R1342 T4534 T4533 dobj contact,initiate
R1343 T4535 T4534 prep between,contact
R1344 T4536 T4537 amod sensory,axons
R1345 T4537 T4535 pobj axons,between
R1346 T4538 T4537 cc and,axons
R1347 T4539 T4540 compound motor,neurons
R1348 T4540 T4537 conj neurons,axons
R1349 T4541 T4533 prep in,initiate
R1352 T5932 T5933 nsubjpass NT,Required
R1353 T5934 T5932 punct -,NT
R1354 T5935 T5932 nummod 3,NT
R1355 T5936 T5933 auxpass Is,Required
R1356 T5937 T5933 prep for,Required
R1357 T5938 T5939 amod Proper,Innervation
R1358 T5939 T5937 pobj Innervation,for
R1359 T5940 T5939 amod Peripheral,Innervation
R1360 T5942 T5943 prep In,investigated
R1361 T5944 T5942 pobj order,In
R1362 T5945 T5946 aux to,study
R1363 T5946 T5944 acl study,order
R1364 T5947 T5948 amod peripheral,innervation
R1365 T5948 T5946 dobj innervation,study
R1366 T5949 T5946 prep in,study
R1367 T5950 T5951 amod double,KO
R1368 T5951 T5952 compound KO,animals
R1369 T5952 T5949 pobj animals,in
R1370 T5953 T5943 punct ", ",investigated
R1371 T5954 T5943 nsubj we,investigated
R1372 T5955 T5956 compound spindle,development
R1373 T5956 T5943 dobj development,investigated
R1374 T5957 T5956 prep in,development
R1375 T5958 T5959 det the,muscle
R1376 T5959 T5957 pobj muscle,in
R1377 T5960 T5959 compound gastrocnemius,muscle
R1378 T5961 T5943 punct .,investigated
R1379 T5963 T5964 compound Muscle,spindles
R1380 T5964 T5965 nsubjpass spindles,identified
R1381 T5966 T5965 aux could,identified
R1382 T5967 T5965 auxpass be,identified
R1383 T5968 T5965 advmod easily,identified
R1384 T5969 T5965 prep in,identified
R1385 T5970 T5971 nmod P0,animals
R1386 T5971 T5969 pobj animals,in
R1387 T5972 T5971 nmod WT,animals
R1388 T5973 T5972 cc and,WT
R1389 T5974 T5975 compound Bax,KO
R1390 T5975 T5972 conj KO,WT
R1391 T5976 T5965 prep by,identified
R1392 T5977 T5978 poss their,morphology
R1393 T5978 T5976 pobj morphology,by
R1394 T5979 T5978 amod characteristic,morphology
R1395 T5980 T5981 punct (,4A
R1396 T5981 T5965 parataxis 4A,identified
R1397 T5982 T5981 compound Figure,4A
R1398 T5983 T5981 cc and,4A
R1399 T5984 T5981 conj 4B,4A
R1400 T5985 T5981 punct ),4A
R1401 T5986 T5965 punct .,identified
R1402 T5988 T5989 amod Proprioceptive,fibers
R1403 T5989 T5990 nsubj fibers,formed
R1404 T5991 T5989 acl labeled,fibers
R1405 T5992 T5991 prep with,labeled
R1406 T5993 T5994 nmod neurofilament,M
R1407 T5994 T5996 nmod M,antibody
R1408 T5995 T5994 punct -,M
R1409 T5996 T5992 pobj antibody,with
R1410 T5997 T5994 punct (,M
R1411 T5998 T5999 compound NF,M
R1412 T5999 T5994 appos M,M
R1413 T6000 T5999 punct -,M
R1414 T6001 T5996 punct ),antibody
R1415 T6002 T6003 npadvmod ring,like
R1416 T6003 T6005 amod like,endings
R1417 T6004 T6003 punct -,like
R1418 T6005 T5990 dobj endings,formed
R1419 T6006 T6005 amod spiral,endings
R1420 T6007 T6005 acl wrapped,endings
R1421 T6008 T6007 prep around,wrapped
R1422 T6009 T6010 amod intrafusal,fibers
R1423 T6010 T6008 pobj fibers,around
R1424 T6011 T6010 compound bag,fibers
R1425 T6012 T6010 acl labeled,fibers
R1426 T6013 T6012 prep with,labeled
R1427 T6014 T6015 compound S46,antibody
R1428 T6015 T6013 pobj antibody,with
R1429 T6016 T6015 punct ", ",antibody
R1430 T6017 T6015 amod specific,antibody
R1431 T6018 T6017 prep for,specific
R1432 T6019 T6020 amod slow,developmental
R1433 T6020 T6021 amod developmental,protein
R1434 T6021 T6018 pobj protein,for
R1435 T6022 T6021 nmod myosin,protein
R1436 T6023 T6024 amod heavy,chain
R1437 T6024 T6021 compound chain,protein
R1438 T6025 T6026 punct (,Miller
R1439 T6026 T5990 meta Miller,formed
R1440 T6027 T6026 nmod et,Miller
R1441 T6028 T6026 nmod al.,Miller
R1442 T6029 T6026 nummod 1985,Miller
R1443 T6030 T6026 punct ),Miller
R1444 T6031 T5990 punct .,formed
R1445 T6033 T6034 mark As,reported
R1446 T6034 T6035 advcl reported,were
R1447 T6036 T6034 advmod earlier,reported
R1448 T6037 T6035 punct ", ",were
R1449 T6038 T6035 expl there,were
R1450 T6039 T6040 det no,spindles
R1451 T6040 T6035 attr spindles,were
R1452 T6041 T6040 compound muscle,spindles
R1453 T6042 T6035 prep in,were
R1454 T6043 T6044 nmod NT,KO
R1455 T6044 T6047 compound KO,animals
R1456 T6045 T6043 punct -,NT
R1457 T6046 T6043 nummod 3,NT
R1458 T6047 T6042 pobj animals,in
R1459 T6048 T6049 punct (,Ernfors
R1460 T6049 T6035 meta Ernfors,were
R1461 T6050 T6049 nmod et,Ernfors
R1462 T6051 T6049 nmod al.,Ernfors
R1463 T6052 T6049 nummod 1994,Ernfors
R1464 T6053 T6049 punct ),Ernfors
R1465 T6054 T6035 punct .,were
R1466 T6056 T6057 prep On,had
R1467 T6058 T6059 det the,hand
R1468 T6059 T6056 pobj hand,On
R1469 T6060 T6059 amod other,hand
R1470 T6061 T6057 punct ", ",had
R1471 T6062 T6063 compound Bax,KO
R1472 T6063 T6064 compound KO,animals
R1473 T6064 T6057 nsubj animals,had
R1474 T6065 T6066 amod more,spindles
R1475 T6066 T6057 dobj spindles,had
R1476 T6067 T6068 mark than,WT
R1477 T6068 T6066 advcl WT,spindles
R1478 T6069 T6057 punct ", ",had
R1479 T6070 T6057 cc and,had
R1480 T6071 T6072 nsubj spindles,were
R1481 T6072 T6057 conj were,had
R1482 T6073 T6072 prep in,were
R1483 T6074 T6073 pobj clusters,in
R1484 T6075 T6072 advcl similar,were
R1485 T6076 T6075 prep to,similar
R1486 T6077 T6076 pobj animals,to
R1487 T6078 T6077 acl over-expressing,animals
R1488 T6079 T6078 dobj NT,over-expressing
R1489 T6080 T6079 punct -,NT
R1490 T6081 T6079 nummod 3,NT
R1491 T6082 T6078 prep in,over-expressing
R1492 T6083 T6084 det the,muscle
R1493 T6084 T6082 pobj muscle,in
R1494 T6085 T6086 punct (,Wright
R1495 T6086 T6072 meta Wright,were
R1496 T6087 T6086 nmod et,Wright
R1497 T6088 T6086 nmod al.,Wright
R1498 T6089 T6086 nummod 1997,Wright
R1499 T6090 T6086 punct ),Wright
R1500 T6091 T6072 punct .,were
R1501 T6093 T6094 mark Although,rescued
R1502 T6094 T6102 advcl rescued,detected
R1503 T6095 T6096 npadvmod NT,dependent
R1504 T6096 T6100 amod dependent,cells
R1505 T6097 T6095 punct -,NT
R1506 T6098 T6095 nummod 3,NT
R1507 T6099 T6096 punct -,dependent
R1508 T6100 T6094 nsubjpass cells,rescued
R1509 T6101 T6094 auxpass were,rescued
R1510 T6103 T6102 punct ", ",detected
R1511 T6104 T6105 det no,spindles
R1512 T6105 T6102 nsubjpass spindles,detected
R1513 T6106 T6105 compound muscle,spindles
R1514 T6107 T6102 auxpass were,detected
R1515 T6108 T6102 prep in,detected
R1516 T6109 T6110 det the,limbs
R1517 T6110 T6108 pobj limbs,in
R1518 T6111 T6110 prep of,limbs
R1519 T6112 T6113 amod double,KOs
R1520 T6113 T6111 pobj KOs,of
R1521 T6114 T6115 punct (,4A
R1522 T6115 T6102 parataxis 4A,detected
R1523 T6116 T6115 compound Figure,4A
R1524 T6117 T6115 cc and,4A
R1525 T6118 T6115 conj 4B,4A
R1526 T6119 T6115 punct ),4A
R1527 T6120 T6102 punct .,detected
R1528 T6122 T6123 compound Muscle,spindles
R1529 T6123 T6124 nsubjpass spindles,observed
R1530 T6125 T6124 aux could,observed
R1531 T6126 T6124 auxpass be,observed
R1532 T6127 T6124 prep with,observed
R1533 T6128 T6129 compound TrkC,antibody
R1534 T6129 T6127 pobj antibody,with
R1535 T6130 T6124 prep in,observed
R1536 T6131 T6132 nmod WT,animals
R1537 T6132 T6130 pobj animals,in
R1538 T6133 T6131 cc and,WT
R1539 T6134 T6135 compound Bax,KO
R1540 T6135 T6131 conj KO,WT
R1541 T6136 T6130 punct ", ",in
R1542 T6137 T6130 cc but,in
R1543 T6138 T6137 neg not,but
R1544 T6139 T6130 conj in,in
R1545 T6140 T6141 nmod NT,KOs
R1546 T6141 T6139 pobj KOs,in
R1547 T6142 T6140 punct -,NT
R1548 T6143 T6140 nummod 3,NT
R1549 T6144 T6140 cc or,NT
R1550 T6145 T6140 conj double,NT
R1551 T6146 T6147 punct (,4E
R1552 T6147 T6124 parataxis 4E,observed
R1553 T6148 T6147 compound Figure,4E
R1554 T6149 T6147 punct ),4E
R1555 T6150 T6124 punct .,observed
R1556 T6152 T6153 prep In,detected
R1557 T6153 T6171 ccomp detected,were
R1558 T6154 T6155 preconj both,NT
R1559 T6155 T6156 nmod NT,KO
R1560 T6156 T6161 compound KO,animals
R1561 T6157 T6155 punct -,NT
R1562 T6158 T6155 nummod 3,NT
R1563 T6159 T6155 cc and,NT
R1564 T6160 T6155 conj double,NT
R1565 T6161 T6152 pobj animals,In
R1566 T6162 T6153 punct ", ",detected
R1567 T6163 T6164 compound NF,M
R1568 T6164 T6166 npadvmod M,labeled
R1569 T6165 T6164 punct -,M
R1570 T6166 T6168 amod labeled,fibers
R1571 T6167 T6166 punct -,labeled
R1572 T6168 T6153 nsubjpass fibers,detected
R1573 T6169 T6153 aux could,detected
R1574 T6170 T6153 auxpass be,detected
R1575 T6172 T6153 prep in,detected
R1576 T6173 T6172 pobj muscles,in
R1577 T6174 T6171 punct ", ",were
R1578 T6175 T6171 advmod thus,were
R1579 T6176 T6177 det the,muscles
R1580 T6177 T6171 nsubj muscles,were
R1581 T6178 T6177 prep of,muscles
R1582 T6179 T6180 det these,animals
R1583 T6180 T6178 pobj animals,of
R1584 T6181 T6171 neg not,were
R1585 T6182 T6183 advmod completely,devoid
R1586 T6183 T6171 acomp devoid,were
R1587 T6184 T6183 prep of,devoid
R1588 T6185 T6186 compound nerve,fibers
R1589 T6186 T6184 pobj fibers,of
R1590 T6187 T6171 punct .,were
R1591 T6189 T6190 mark Since,were
R1592 T6190 T6192 advcl were,think
R1593 T6191 T6190 expl there,were
R1594 T6193 T6194 det no,fibers
R1595 T6194 T6190 attr fibers,were
R1596 T6195 T6194 nmod TrkC,fibers
R1597 T6196 T6195 punct -,TrkC
R1598 T6197 T6195 amod positive,TrkC
R1599 T6198 T6190 prep in,were
R1600 T6199 T6200 det these,muscles
R1601 T6200 T6198 pobj muscles,in
R1602 T6201 T6192 punct ", ",think
R1603 T6202 T6192 nsubj we,think
R1604 T6203 T6204 mark that,correspond
R1605 T6204 T6192 ccomp correspond,think
R1606 T6205 T6206 det these,fibers
R1607 T6206 T6204 nsubj fibers,correspond
R1608 T6207 T6208 compound NF,M
R1609 T6208 T6210 npadvmod M,labeled
R1610 T6209 T6208 punct -,M
R1611 T6210 T6206 amod labeled,fibers
R1612 T6211 T6210 punct -,labeled
R1613 T6212 T6204 prep to,correspond
R1614 T6213 T6214 compound motor,axons
R1615 T6214 T6212 pobj axons,to
R1616 T6215 T6192 punct .,think
R1617 T6217 T6218 nsubj Absence,be
R1618 T6219 T6217 prep of,Absence
R1619 T6220 T6221 compound muscle,spindles
R1620 T6221 T6219 pobj spindles,of
R1621 T6222 T6218 aux might,be
R1622 T6223 T6218 prep due,be
R1623 T6224 T6223 pcomp to,due
R1624 T6225 T6226 det a,failure
R1625 T6226 T6223 pobj failure,due
R1626 T6227 T6226 prep in,failure
R1627 T6228 T6227 pobj initiation,in
R1628 T6229 T6228 prep of,initiation
R1629 T6230 T6229 pobj differentiation,of
R1630 T6231 T6228 prep by,initiation
R1631 T6232 T6233 amod proprioceptive,axons
R1632 T6233 T6231 pobj axons,by
R1633 T6234 T6226 punct ", ",failure
R1634 T6235 T6226 cc or,failure
R1635 T6236 T6237 det a,failure
R1636 T6237 T6226 conj failure,failure
R1637 T6238 T6237 prep of,failure
R1638 T6239 T6238 pobj maturation,of
R1639 T6240 T6239 cc and,maturation
R1640 T6241 T6239 conj maintenance,maturation
R1641 T6242 T6239 prep in,maturation
R1642 T6243 T6244 det the,absence
R1643 T6244 T6242 pobj absence,in
R1644 T6245 T6244 prep of,absence
R1645 T6246 T6245 pobj NT,of
R1646 T6247 T6246 punct -,NT
R1647 T6248 T6246 nummod 3,NT
R1648 T6249 T6218 punct .,be
R1649 T6251 T6252 aux To,distinguish
R1650 T6252 T6253 advcl distinguish,investigated
R1651 T6254 T6252 prep between,distinguish
R1652 T6255 T6256 det these,possibilities
R1653 T6256 T6254 pobj possibilities,between
R1654 T6257 T6256 nummod two,possibilities
R1655 T6258 T6253 punct ", ",investigated
R1656 T6259 T6253 nsubj we,investigated
R1657 T6260 T6261 compound muscle,spindle
R1658 T6261 T6262 compound spindle,development
R1659 T6262 T6253 dobj development,investigated
R1660 T6263 T6253 prep at,investigated
R1661 T6264 T6263 pobj E15,at
R1662 T6265 T6264 cc and,E15
R1663 T6266 T6264 conj E17,E15
R1664 T6267 T6253 prep with,investigated
R1665 T6268 T6269 nmod S46,immunostaining
R1666 T6269 T6267 pobj immunostaining,with
R1667 T6270 T6268 punct /,S46
R1668 T6271 T6272 compound NF,M
R1669 T6272 T6268 appos M,S46
R1670 T6273 T6272 punct -,M
R1671 T6274 T6275 advmod as,as
R1672 T6275 T6269 cc as,immunostaining
R1673 T6276 T6275 advmod well,as
R1674 T6277 T6278 compound DiI,labeling
R1675 T6278 T6269 conj labeling,immunostaining
R1676 T6279 T6253 punct .,investigated
R1677 T6281 T6282 det No,structures
R1678 T6282 T6283 nsubjpass structures,detected
R1679 T6284 T6282 prep with,structures
R1680 T6285 T6286 det the,shape
R1681 T6286 T6284 pobj shape,with
R1682 T6287 T6286 amod characteristic,shape
R1683 T6288 T6289 compound muscle,spindle
R1684 T6289 T6286 compound spindle,shape
R1685 T6290 T6283 aux could,detected
R1686 T6291 T6283 auxpass be,detected
R1687 T6292 T6283 prep in,detected
R1688 T6293 T6292 pobj any,in
R1689 T6294 T6293 prep of,any
R1690 T6295 T6296 det the,genotypes
R1691 T6296 T6294 pobj genotypes,of
R1692 T6297 T6283 prep at,detected
R1693 T6298 T6297 pobj E15,at
R1694 T6299 T6300 punct (,S2
R1695 T6300 T6283 parataxis S2,detected
R1696 T6301 T6300 compound Figure,S2
R1697 T6302 T6300 punct ),S2
R1698 T6303 T6283 punct .,detected
R1699 T6305 T6306 advmod However,identified
R1700 T6307 T6306 punct ", ",identified
R1701 T6308 T6309 amod numerous,spindles
R1702 T6309 T6306 nsubjpass spindles,identified
R1703 T6310 T6309 amod developing,spindles
R1704 T6311 T6306 aux could,identified
R1705 T6312 T6306 auxpass be,identified
R1706 T6313 T6306 prep at,identified
R1707 T6314 T6313 pobj E17,at
R1708 T6315 T6306 prep in,identified
R1709 T6316 T6315 pobj WT,in
R1710 T6317 T6316 cc and,WT
R1711 T6318 T6319 compound Bax,KOs
R1712 T6319 T6316 conj KOs,WT
R1713 T6320 T6315 punct ", ",in
R1714 T6321 T6315 cc but,in
R1715 T6322 T6321 neg not,but
R1716 T6323 T6315 conj in,in
R1717 T6324 T6325 nmod NT,KO
R1718 T6325 T6328 compound KO,embryos
R1719 T6326 T6324 punct -,NT
R1720 T6327 T6324 nummod 3,NT
R1721 T6328 T6323 pobj embryos,in
R1722 T6329 T6330 punct (,4C
R1723 T6330 T6306 parataxis 4C,identified
R1724 T6331 T6330 compound Figure,4C
R1725 T6332 T6330 punct ),4C
R1726 T6333 T6306 punct .,identified
R1727 T6335 T6336 npadvmod Bax,null
R1728 T6336 T6342 amod null,muscles
R1729 T6337 T6335 punct /,Bax
R1730 T6338 T6335 appos NT,Bax
R1731 T6339 T6338 punct -,NT
R1732 T6340 T6338 nummod 3,NT
R1733 T6341 T6336 amod double,null
R1734 T6342 T6343 nsubj muscles,were
R1735 T6344 T6343 acomp devoid,were
R1736 T6345 T6344 prep of,devoid
R1737 T6346 T6345 pobj spindles,of
R1738 T6347 T6348 punct (,4C
R1739 T6348 T6344 parataxis 4C,devoid
R1740 T6349 T6348 compound Figure,4C
R1741 T6350 T6348 punct ),4C
R1742 T6351 T6343 punct ", ",were
R1743 T6352 T6343 prep except,were
R1744 T6353 T6352 prep for,except
R1745 T6354 T6355 nummod one,structure
R1746 T6355 T6353 pobj structure,for
R1747 T6356 T6357 npadvmod spindle,like
R1748 T6357 T6355 amod like,structure
R1749 T6358 T6357 punct -,like
R1750 T6359 T6355 acl observed,structure
R1751 T6360 T6359 prep in,observed
R1752 T6361 T6362 nummod one,leg
R1753 T6362 T6360 pobj leg,in
R1754 T6363 T6362 prep of,leg
R1755 T6364 T6365 det an,embryo
R1756 T6365 T6363 pobj embryo,of
R1757 T6366 T6367 punct (,denoted
R1758 T6367 T6343 parataxis denoted,were
R1759 T6368 T6369 compound Figure,4C
R1760 T6369 T6367 dep 4C,denoted
R1761 T6370 T6367 punct ", ",denoted
R1762 T6371 T6367 dep inset,denoted
R1763 T6372 T6367 punct ", ",denoted
R1764 T6373 T6367 prep by,denoted
R1765 T6374 T6375 det the,asterisk
R1766 T6375 T6373 pobj asterisk,by
R1767 T6376 T6367 punct ),denoted
R1768 T6377 T6343 punct .,were
R1769 T6379 T6380 compound DiI,labeling
R1770 T6380 T6381 nsubj labeling,yielded
R1771 T6382 T6380 prep through,labeling
R1772 T6383 T6384 det the,DRGs
R1773 T6384 T6382 pobj DRGs,through
R1774 T6385 T6380 prep at,labeling
R1775 T6386 T6385 pobj E17,at
R1776 T6387 T6388 amod similar,results
R1777 T6388 T6381 dobj results,yielded
R1778 T6389 T6381 punct ", ",yielded
R1779 T6390 T6391 mark with,identified
R1780 T6391 T6381 advcl identified,yielded
R1781 T6392 T6393 compound muscle,spindles
R1782 T6393 T6391 nsubj spindles,identified
R1783 T6394 T6391 prep in,identified
R1784 T6395 T6396 amod parallel,sections
R1785 T6396 T6394 pobj sections,in
R1786 T6397 T6396 prep in,sections
R1787 T6398 T6399 nmod WT,muscles
R1788 T6399 T6397 pobj muscles,in
R1789 T6400 T6398 cc and,WT
R1790 T6401 T6402 npadvmod Bax,null
R1791 T6402 T6398 conj null,WT
R1792 T6403 T6404 punct (,4D
R1793 T6404 T6396 parataxis 4D,sections
R1794 T6405 T6404 compound Figure,4D
R1795 T6406 T6404 punct ),4D
R1796 T6407 T6394 punct ", ",in
R1797 T6408 T6394 cc but,in
R1798 T6409 T6408 neg not,but
R1799 T6410 T6394 conj in,in
R1800 T6411 T6412 nmod NT,KO
R1801 T6412 T6417 compound KO,animals
R1802 T6413 T6411 punct -,NT
R1803 T6414 T6411 nummod 3,NT
R1804 T6415 T6411 cc or,NT
R1805 T6416 T6411 conj double,NT
R1806 T6417 T6410 pobj animals,in
R1807 T6418 T6381 punct .,yielded
R1808 T6420 T6421 mark Although,detected
R1809 T6421 T6428 advcl detected,formed
R1810 T6422 T6423 npadvmod DiI,labeled
R1811 T6423 T6425 amod labeled,fibers
R1812 T6424 T6423 punct -,labeled
R1813 T6425 T6421 nsubjpass fibers,detected
R1814 T6426 T6421 aux could,detected
R1815 T6427 T6421 auxpass be,detected
R1816 T6429 T6421 prep in,detected
R1817 T6430 T6431 amod double,null
R1818 T6431 T6432 amod null,muscles
R1819 T6432 T6429 pobj muscles,in
R1820 T6433 T6428 punct ", ",formed
R1821 T6434 T6428 nsubj they,formed
R1822 T6435 T6428 neg never,formed
R1823 T6436 T6437 npadvmod ring,like
R1824 T6437 T6439 amod like,structures
R1825 T6438 T6437 punct -,like
R1826 T6439 T6428 dobj structures,formed
R1827 T6440 T6439 amod characteristic,structures
R1828 T6441 T6440 prep of,characteristic
R1829 T6442 T6443 compound muscle,spindles
R1830 T6443 T6441 pobj spindles,of
R1831 T6444 T6428 punct .,formed
R1832 T6446 T6447 nsubj We,examined
R1833 T6448 T6447 advmod also,examined
R1834 T6449 T6450 compound TrkA,TrkC
R1835 T6450 T6452 compound TrkC,expression
R1836 T6451 T6450 punct /,TrkC
R1837 T6452 T6447 dobj expression,examined
R1838 T6453 T6447 prep at,examined
R1839 T6454 T6453 pobj P0,at
R1840 T6455 T6447 prep in,examined
R1841 T6456 T6457 det the,nerve
R1842 T6457 T6455 pobj nerve,in
R1843 T6458 T6457 amod tibial,nerve
R1844 T6459 T6457 punct ", ",nerve
R1845 T6460 T6461 dep which,carries
R1846 T6461 T6457 relcl carries,nerve
R1847 T6462 T6463 amod sensory,fibers
R1848 T6463 T6461 dobj fibers,carries
R1849 T6464 T6461 prep to,carries
R1850 T6465 T6466 det the,muscle
R1851 T6466 T6464 pobj muscle,to
R1852 T6467 T6466 compound gastrocnemius,muscle
R1853 T6468 T6469 advmod as,as
R1854 T6469 T6466 cc as,muscle
R1855 T6470 T6469 advmod well,as
R1856 T6471 T6472 det the,skin
R1857 T6472 T6466 conj skin,muscle
R1858 T6473 T6472 prep of,skin
R1859 T6474 T6475 det the,leg
R1860 T6475 T6473 pobj leg,of
R1861 T6476 T6475 amod lower,leg
R1862 T6477 T6447 punct .,examined
R1863 T6479 T6480 prep In,seen
R1864 T6480 T6492 ccomp seen,are
R1865 T6481 T6482 nmod NT,KOs
R1866 T6482 T6479 pobj KOs,In
R1867 T6483 T6481 punct -,NT
R1868 T6484 T6481 nummod 3,NT
R1869 T6485 T6480 punct ", ",seen
R1870 T6486 T6487 npadvmod TrkA,positive
R1871 T6487 T6489 amod positive,axons
R1872 T6488 T6487 punct -,positive
R1873 T6489 T6480 nsubjpass axons,seen
R1874 T6490 T6480 aux could,seen
R1875 T6491 T6480 auxpass be,seen
R1876 T6493 T6480 prep in,seen
R1877 T6494 T6495 det the,nerve
R1878 T6495 T6493 pobj nerve,in
R1879 T6496 T6495 amod tibial,nerve
R1880 T6497 T6480 cc but,seen
R1881 T6498 T6499 expl there,were
R1882 T6499 T6480 conj were,seen
R1883 T6500 T6501 det no,axons
R1884 T6501 T6499 attr axons,were
R1885 T6502 T6503 npadvmod TrkC,positive
R1886 T6503 T6501 amod positive,axons
R1887 T6504 T6503 punct -,positive
R1888 T6505 T6492 punct ;,are
R1889 T6506 T6492 prep in,are
R1890 T6507 T6506 pobj contrast,in
R1891 T6508 T6492 punct ", ",are
R1892 T6509 T6510 npadvmod TrkA,labeled
R1893 T6510 T6515 amod labeled,axons
R1894 T6511 T6509 punct -,TrkA
R1895 T6512 T6509 cc and,TrkA
R1896 T6513 T6509 conj TrkC,TrkA
R1897 T6514 T6510 punct -,labeled
R1898 T6515 T6492 nsubj axons,are
R1899 T6516 T6492 advmod both,are
R1900 T6517 T6492 acomp present,are
R1901 T6518 T6492 prep in,are
R1902 T6519 T6520 nmod WT,animals
R1903 T6520 T6518 pobj animals,in
R1904 T6521 T6519 punct ", ",WT
R1905 T6522 T6523 compound Bax,KO
R1906 T6523 T6519 conj KO,WT
R1907 T6524 T6523 punct ", ",KO
R1908 T6525 T6523 cc and,KO
R1909 T6526 T6527 amod double,KO
R1910 T6527 T6523 conj KO,KO
R1911 T6528 T6529 punct (,4F
R1912 T6529 T6492 parataxis 4F,are
R1913 T6530 T6529 compound Figure,4F
R1914 T6531 T6529 punct ),4F
R1915 T6532 T6492 punct .,are
R1916 T6534 T6535 det These,results
R1917 T6535 T6536 nsubj results,suggest
R1918 T6537 T6538 mark that,fail
R1919 T6538 T6536 ccomp fail,suggest
R1920 T6539 T6540 mark although,follow
R1921 T6540 T6538 advcl follow,fail
R1922 T6541 T6542 amod proprioceptive,axons
R1923 T6542 T6540 nsubj axons,follow
R1924 T6543 T6544 amod proper,trajectories
R1925 T6544 T6540 dobj trajectories,follow
R1926 T6545 T6540 prep in,follow
R1927 T6546 T6547 amod distal,nerves
R1928 T6547 T6545 pobj nerves,in
R1929 T6548 T6547 amod peripheral,nerves
R1930 T6549 T6538 punct ", ",fail
R1931 T6550 T6538 nsubj they,fail
R1932 T6551 T6552 aux to,innervate
R1933 T6552 T6538 xcomp innervate,fail
R1934 T6553 T6554 poss their,muscles
R1935 T6554 T6552 dobj muscles,innervate
R1936 T6555 T6554 compound target,muscles
R1937 T6556 T6552 prep in,innervate
R1938 T6557 T6558 det the,absence
R1939 T6558 T6556 pobj absence,in
R1940 T6559 T6558 prep of,absence
R1941 T6560 T6559 pobj NT,of
R1942 T6561 T6560 punct -,NT
R1943 T6562 T6560 nummod 3,NT
R1944 T6563 T6536 punct .,suggest
R1945 T7869 T7870 nsubj NT,Is
R1946 T7871 T7869 punct -,NT
R1947 T7872 T7869 nummod 3,NT
R1948 T7873 T7874 det a,Chemoattractant
R1949 T7874 T7870 attr Chemoattractant,Is
R1950 T7875 T7874 prep for,Chemoattractant
R1951 T7876 T7877 compound DRG,Axons
R1952 T7877 T7875 pobj Axons,for
R1953 T7878 T7879 advmod In,Vitro
R1954 T7879 T7870 advmod Vitro,Is
R1955 T7881 T7882 aux To,test
R1956 T7882 T7883 advcl test,performed
R1957 T7884 T7885 det the,hypothesis
R1958 T7885 T7882 dobj hypothesis,test
R1959 T7886 T7887 mark that,acts
R1960 T7887 T7885 acl acts,hypothesis
R1961 T7888 T7887 nsubj NT,acts
R1962 T7889 T7888 punct -,NT
R1963 T7890 T7888 nummod 3,NT
R1964 T7891 T7887 prep as,acts
R1965 T7892 T7893 det a,chemoattractant
R1966 T7893 T7891 pobj chemoattractant,as
R1967 T7894 T7893 prep for,chemoattractant
R1968 T7895 T7896 amod sensory,axons
R1969 T7896 T7894 pobj axons,for
R1970 T7897 T7883 punct ", ",performed
R1971 T7898 T7883 nsubj we,performed
R1972 T7899 T7900 det a,series
R1973 T7900 T7883 dobj series,performed
R1974 T7901 T7900 prep of,series
R1975 T7902 T7903 advmod in,vitro
R1976 T7903 T7904 amod vitro,assays
R1977 T7904 T7901 pobj assays,of
R1978 T7905 T7883 punct .,performed
R1979 T7907 T7908 amod Proprioceptive,axons
R1980 T7908 T7909 nsubj axons,enter
R1981 T7910 T7908 prep in,axons
R1982 T7911 T7910 pobj mice,in
R1983 T7912 T7913 det the,matter
R1984 T7913 T7909 dobj matter,enter
R1985 T7914 T7913 amod gray,matter
R1986 T7915 T7913 prep in,matter
R1987 T7916 T7917 det the,cord
R1988 T7917 T7915 pobj cord,in
R1989 T7918 T7917 amod spinal,cord
R1990 T7919 T7909 cc and,enter
R1991 T7920 T7909 conj advance,enter
R1992 T7921 T7920 advmod ventrally,advance
R1993 T7922 T7920 advcl parallel,advance
R1994 T7923 T7922 prep to,parallel
R1995 T7924 T7925 det the,midline
R1996 T7925 T7923 pobj midline,to
R1997 T7926 T7920 prep by,advance
R1998 T7927 T7926 pobj E13,by
R1999 T7928 T7920 cc and,advance
R2000 T7929 T7920 conj reach,advance
R2001 T7930 T7931 det the,neurons
R2002 T7931 T7929 dobj neurons,reach
R2003 T7932 T7931 compound motor,neurons
R2004 T7933 T7929 prep by,reach
R2005 T7934 T7933 pobj E15,by
R2006 T7935 T7936 punct (,Ozaki
R2007 T7936 T7929 meta Ozaki,reach
R2008 T7937 T7936 cc and,Ozaki
R2009 T7938 T7936 conj Snider,Ozaki
R2010 T7939 T7938 nummod 1994,Snider
R2011 T7940 T7938 punct ),Snider
R2012 T7941 T7909 punct .,enter
R2013 T7943 T7944 nsubj We,co-cultured
R2014 T7945 T7946 npadvmod collagen,embedded
R2015 T7946 T7948 amod embedded,explants
R2016 T7947 T7946 punct -,embedded
R2017 T7948 T7944 dobj explants,co-cultured
R2018 T7949 T7948 compound E13,explants
R2019 T7950 T7948 compound WT,explants
R2020 T7951 T7948 compound DRG,explants
R2021 T7952 T7944 prep with,co-cultured
R2022 T7953 T7954 npadvmod NT,soaked
R2023 T7954 T7958 amod soaked,beads
R2024 T7955 T7953 punct -,NT
R2025 T7956 T7953 nummod 3,NT
R2026 T7957 T7954 punct -,soaked
R2027 T7958 T7952 pobj beads,with
R2028 T7959 T7958 compound sepharose,beads
R2029 T7960 T7961 punct (,26
R2030 T7961 T7944 parataxis 26,co-cultured
R2031 T7962 T7961 nsubj n,26
R2032 T7963 T7961 punct =,26
R2033 T7964 T7961 punct ),26
R2034 T7965 T7944 punct .,co-cultured
R2035 T7967 T7968 compound Control,cultures
R2036 T7968 T7969 nsubjpass cultures,set
R2037 T7970 T7969 auxpass were,set
R2038 T7971 T7969 prt up,set
R2039 T7972 T7969 advcl using,set
R2040 T7973 T7974 amod bovine,albumin
R2041 T7974 T7976 npadvmod albumin,soaked
R2042 T7975 T7974 compound serum,albumin
R2043 T7976 T7989 amod soaked,beads
R2044 T7977 T7974 punct (,albumin
R2045 T7978 T7974 appos BSA,albumin
R2046 T7979 T7974 punct ),albumin
R2047 T7980 T7974 punct –,albumin
R2048 T7981 T7974 cc or,albumin
R2049 T7982 T7983 compound phosphate,saline
R2050 T7983 T7974 conj saline,albumin
R2051 T7984 T7983 compound buffer,saline
R2052 T7985 T7983 punct (,saline
R2053 T7986 T7983 appos PBS,saline
R2054 T7987 T7976 punct ),soaked
R2055 T7988 T7976 punct –,soaked
R2056 T7989 T7972 dobj beads,using
R2057 T7990 T7991 punct (,12
R2058 T7991 T7972 parataxis 12,using
R2059 T7992 T7991 nsubj n,12
R2060 T7993 T7991 punct =,12
R2061 T7994 T7991 punct ),12
R2062 T7995 T7969 punct .,set
R2063 T7997 T7998 compound DRG,axons
R2064 T7998 T7999 nsubj axons,began
R2065 T8000 T7999 xcomp extending,began
R2066 T8001 T8000 prep towards,extending
R2067 T8002 T8003 det the,source
R2068 T8003 T8001 pobj source,towards
R2069 T8004 T8003 amod localized,source
R2070 T8005 T8003 nmod NT,source
R2071 T8006 T8005 punct -,NT
R2072 T8007 T8005 nummod 3,NT
R2073 T8008 T8000 prep by,extending
R2074 T8009 T8010 det the,end
R2075 T8010 T8008 pobj end,by
R2076 T8011 T8010 prep of,end
R2077 T8012 T8013 det the,day
R2078 T8013 T8011 pobj day,of
R2079 T8014 T8013 amod first,day
R2080 T8015 T7999 cc and,began
R2081 T8016 T8017 advmod consistently,displayed
R2082 T8017 T7999 conj displayed,began
R2083 T8018 T8019 det a,chemoattraction
R2084 T8019 T8017 dobj chemoattraction,displayed
R2085 T8020 T8019 amod strong,chemoattraction
R2086 T8021 T8017 prep by,displayed
R2087 T8022 T8023 nummod 3,d
R2088 T8023 T8021 pobj d,by
R2089 T8024 T8025 advmod in,vitro
R2090 T8025 T8023 advmod vitro,d
R2091 T8026 T8017 punct ", ",displayed
R2092 T8027 T8028 mark whereas,show
R2093 T8028 T8017 advcl show,displayed
R2094 T8029 T8028 nsubj they,show
R2095 T8030 T8028 aux did,show
R2096 T8031 T8028 neg not,show
R2097 T8032 T8033 amod such,preference
R2098 T8033 T8028 dobj preference,show
R2099 T8034 T8033 prep for,preference
R2100 T8035 T8036 npadvmod BSA,loaded
R2101 T8036 T8038 amod loaded,beads
R2102 T8037 T8036 punct -,loaded
R2103 T8038 T8034 pobj beads,for
R2104 T8039 T8038 compound control,beads
R2105 T8040 T8041 punct (,5A
R2106 T8041 T8017 parataxis 5A,displayed
R2107 T8042 T8041 compound Figure,5A
R2108 T8043 T8041 cc and,5A
R2109 T8044 T8041 conj 5B,5A
R2110 T8045 T8041 punct ),5A
R2111 T8046 T7999 punct .,began
R2112 T8048 T8049 det This,attraction
R2113 T8049 T8050 nsubj attraction,was
R2114 T8051 T8050 neg not,was
R2115 T8052 T8050 prep due,was
R2116 T8053 T8052 pcomp to,due
R2117 T8054 T8055 compound survival,support
R2118 T8055 T8052 pobj support,due
R2119 T8056 T8055 prep of,support
R2120 T8057 T8056 pobj NT,of
R2121 T8058 T8057 punct -,NT
R2122 T8059 T8057 nummod 3,NT
R2123 T8060 T8061 mark because,displayed
R2124 T8061 T8050 advcl displayed,was
R2125 T8062 T8063 npadvmod Bax,null
R2126 T8063 T8064 amod null,ganglia
R2127 T8064 T8061 nsubj ganglia,displayed
R2128 T8065 T8066 det the,chemoattraction
R2129 T8066 T8061 dobj chemoattraction,displayed
R2130 T8067 T8066 amod same,chemoattraction
R2131 T8068 T8069 punct (,5C
R2132 T8069 T8050 parataxis 5C,was
R2133 T8070 T8069 compound Figure,5C
R2134 T8071 T8069 punct ;,5C
R2135 T8072 T8073 nsubj n,16
R2136 T8073 T8069 ccomp 16,5C
R2137 T8074 T8073 punct =,16
R2138 T8075 T8069 punct ),5C
R2139 T8076 T8050 punct .,was
R2140 T8078 T8079 nsubj NT,act
R2141 T8080 T8078 punct -,NT
R2142 T8081 T8078 nummod 3,NT
R2143 T8082 T8079 aux may,act
R2144 T8083 T8079 prep through,act
R2145 T8084 T8085 preconj either,TrkC
R2146 T8085 T8083 pobj TrkC,through
R2147 T8086 T8085 punct ", ",TrkC
R2148 T8087 T8085 cc or,TrkC
R2149 T8088 T8089 det the,p75NTR
R2150 T8089 T8085 conj p75NTR,TrkC
R2151 T8090 T8079 punct .,act
R2152 T8092 T8093 nsubj We,repeated
R2153 T8094 T8095 det the,experiments
R2154 T8095 T8093 dobj experiments,repeated
R2155 T8096 T8095 compound co-culture,experiments
R2156 T8097 T8093 prep with,repeated
R2157 T8098 T8099 compound DRG,explants
R2158 T8099 T8097 pobj explants,with
R2159 T8100 T8099 acl derived,explants
R2160 T8101 T8100 prep from,derived
R2161 T8102 T8103 compound p75NTR,KO
R2162 T8103 T8104 compound KO,mice
R2163 T8104 T8101 pobj mice,from
R2164 T8105 T8106 punct (,18
R2165 T8106 T8093 parataxis 18,repeated
R2166 T8107 T8106 nsubj n,18
R2167 T8108 T8106 punct =,18
R2168 T8109 T8106 punct ),18
R2169 T8110 T8093 punct .,repeated
R2170 T8112 T8113 nsubj Axons,showed
R2171 T8114 T8112 prep of,Axons
R2172 T8115 T8116 det these,ganglia
R2173 T8116 T8114 pobj ganglia,of
R2174 T8117 T8113 advmod also,showed
R2175 T8118 T8119 amod strong,chemoattraction
R2176 T8119 T8113 dobj chemoattraction,showed
R2177 T8120 T8119 prep towards,chemoattraction
R2178 T8121 T8122 det the,beads
R2179 T8122 T8120 pobj beads,towards
R2180 T8123 T8122 nmod NT,beads
R2181 T8124 T8123 punct -,NT
R2182 T8125 T8123 nummod 3,NT
R2183 T8126 T8127 punct (,5D
R2184 T8127 T8113 parataxis 5D,showed
R2185 T8128 T8127 compound Figure,5D
R2186 T8129 T8127 punct ),5D
R2187 T8130 T8113 punct .,showed
R2188 T8132 T8133 advmod Finally,used
R2189 T8134 T8133 punct ", ",used
R2190 T8135 T8133 nsubj we,used
R2191 T8136 T8137 amod diffusible,receptors
R2192 T8137 T8133 dobj receptors,used
R2193 T8138 T8137 compound TrkC,receptors
R2194 T8139 T8137 acl conjugated,receptors
R2195 T8140 T8139 prep to,conjugated
R2196 T8141 T8142 compound IgG,regions
R2197 T8142 T8140 pobj regions,to
R2198 T8143 T8142 compound constant,regions
R2199 T8144 T8145 punct (,Fc
R2200 T8145 T8142 parataxis Fc,regions
R2201 T8146 T8145 compound TrkC,Fc
R2202 T8147 T8145 punct -,Fc
R2203 T8148 T8145 punct ),Fc
R2204 T8149 T8142 acl added,regions
R2205 T8150 T8149 prep to,added
R2206 T8151 T8152 det the,medium
R2207 T8152 T8150 pobj medium,to
R2208 T8153 T8154 punct (,6
R2209 T8154 T8149 parataxis 6,added
R2210 T8155 T8154 nsubj n,6
R2211 T8156 T8154 punct =,6
R2212 T8157 T8154 punct ),6
R2213 T8158 T8159 aux to,deplete
R2214 T8159 T8133 advcl deplete,used
R2215 T8160 T8161 amod soluble,NT
R2216 T8161 T8159 dobj NT,deplete
R2217 T8162 T8161 punct -,NT
R2218 T8163 T8161 nummod 3,NT
R2219 T8164 T8159 prep from,deplete
R2220 T8165 T8166 det the,gels
R2221 T8166 T8164 pobj gels,from
R2222 T8167 T8166 compound collagen,gels
R2223 T8168 T8169 punct (,5E
R2224 T8169 T8133 parataxis 5E,used
R2225 T8170 T8169 compound Figure,5E
R2226 T8171 T8169 punct ),5E
R2227 T8172 T8133 punct .,used
R2228 T8174 T8175 prep In,blocked
R2229 T8176 T8177 det the,presence
R2230 T8177 T8174 pobj presence,In
R2231 T8178 T8177 prep of,presence
R2232 T8179 T8180 compound TrkC,Fc
R2233 T8180 T8178 pobj Fc,of
R2234 T8181 T8180 punct -,Fc
R2235 T8182 T8183 det the,chemoattraction
R2236 T8183 T8175 nsubjpass chemoattraction,blocked
R2237 T8184 T8175 auxpass was,blocked
R2238 T8185 T8175 advmod completely,blocked
R2239 T8186 T8175 punct ", ",blocked
R2240 T8187 T8175 advcl demonstrating,blocked
R2241 T8188 T8189 mark that,is
R2242 T8189 T8187 ccomp is,demonstrating
R2243 T8190 T8191 det the,effect
R2244 T8191 T8189 nsubj effect,is
R2245 T8192 T8193 nsubj we,see
R2246 T8193 T8191 advcl see,effect
R2247 T8194 T8189 acomp specific,is
R2248 T8195 T8194 prep for,specific
R2249 T8196 T8195 pobj NT,for
R2250 T8197 T8196 punct -,NT
R2251 T8198 T8196 nummod 3,NT
R2252 T8199 T8175 punct .,blocked
R2253 T8201 T8202 prep In,repeated
R2254 T8203 T8201 pobj order,In
R2255 T8204 T8205 aux to,investigate
R2256 T8205 T8203 acl investigate,order
R2257 T8206 T8207 det the,range
R2258 T8207 T8205 dobj range,investigate
R2259 T8208 T8207 amod active,range
R2260 T8209 T8207 prep of,range
R2261 T8210 T8211 poss our,beads
R2262 T8211 T8209 pobj beads,of
R2263 T8212 T8202 punct ", ",repeated
R2264 T8213 T8202 nsubj we,repeated
R2265 T8214 T8202 aux have,repeated
R2266 T8215 T8216 det the,cultures
R2267 T8216 T8202 dobj cultures,repeated
R2268 T8217 T8202 prep with,repeated
R2269 T8218 T8219 compound WT,DRGs
R2270 T8219 T8217 pobj DRGs,with
R2271 T8220 T8219 compound E13,DRGs
R2272 T8221 T8202 prep by,repeated
R2273 T8222 T8221 pcomp placing,by
R2274 T8223 T8224 det the,beads
R2275 T8224 T8222 dobj beads,placing
R2276 T8225 T8222 prep at,placing
R2277 T8226 T8227 amod increasing,distances
R2278 T8227 T8225 pobj distances,at
R2279 T8228 T8227 prep from,distances
R2280 T8229 T8230 det the,ganglia
R2281 T8230 T8228 pobj ganglia,from
R2282 T8231 T8232 punct (,4
R2283 T8232 T8222 parataxis 4,placing
R2284 T8233 T8232 nsubj n,4
R2285 T8234 T8232 punct =,4
R2286 T8235 T8232 appos each,4
R2287 T8236 T8232 punct ),4
R2288 T8237 T8238 punct (,5F
R2289 T8238 T8222 parataxis 5F,placing
R2290 T8239 T8238 compound Figure,5F
R2291 T8240 T8238 punct ),5F
R2292 T8241 T8202 punct .,repeated
R2293 T8243 T8244 expl There,was
R2294 T8245 T8244 advmod still,was
R2295 T8246 T8247 amod preferred,growth
R2296 T8247 T8244 attr growth,was
R2297 T8248 T8247 prep towards,growth
R2298 T8249 T8250 det the,bead
R2299 T8250 T8248 pobj bead,towards
R2300 T8251 T8250 prep at,bead
R2301 T8252 T8253 nummod "1,200",μm
R2302 T8253 T8251 pobj μm,at
R2303 T8254 T8253 punct ", ",μm
R2304 T8255 T8256 det the,distance
R2305 T8256 T8253 appos distance,μm
R2306 T8257 T8256 amod longest,distance
R2307 T8258 T8256 acl studied,distance
R2308 T8259 T8244 punct ", ",was
R2309 T8260 T8261 mark although,were
R2310 T8261 T8244 advcl were,was
R2311 T8262 T8263 det the,number
R2312 T8263 T8261 nsubj number,were
R2313 T8264 T8263 prep of,number
R2314 T8265 T8264 pobj axons,of
R2315 T8266 T8263 cc and,number
R2316 T8267 T8268 det the,extent
R2317 T8268 T8263 conj extent,number
R2318 T8269 T8268 prep of,extent
R2319 T8270 T8269 pobj growth,of
R2320 T8271 T8261 neg not,were
R2321 T8272 T8273 advmod as,robust
R2322 T8273 T8261 acomp robust,were
R2323 T8274 T8244 punct .,was
R2324 T8276 T8277 advmod Next,set
R2325 T8278 T8277 punct ", ",set
R2326 T8279 T8277 nsubj we,set
R2327 T8280 T8277 prt up,set
R2328 T8281 T8282 nmod E13,cultures
R2329 T8282 T8277 dobj cultures,set
R2330 T8283 T8282 nmod DRG,cultures
R2331 T8284 T8285 amod spinal,cord
R2332 T8285 T8282 compound cord,cultures
R2333 T8286 T8282 compound explant,cultures
R2334 T8287 T8277 advcl using,set
R2335 T8288 T8289 npadvmod NT,loaded
R2336 T8289 T8293 amod loaded,beads
R2337 T8290 T8288 punct -,NT
R2338 T8291 T8288 nummod 3,NT
R2339 T8292 T8289 punct -,loaded
R2340 T8293 T8287 dobj beads,using
R2341 T8294 T8293 acl placed,beads
R2342 T8295 T8294 prep at,placed
R2343 T8296 T8297 det the,midline
R2344 T8297 T8295 pobj midline,at
R2345 T8298 T8297 prep at,midline
R2346 T8299 T8300 amod mid-spinal,level
R2347 T8300 T8298 pobj level,at
R2348 T8301 T8300 compound cord,level
R2349 T8302 T8287 prep as,using
R2350 T8303 T8304 det an,source
R2351 T8304 T8302 pobj source,as
R2352 T8305 T8304 amod ectopic,source
R2353 T8306 T8304 nmod NT,source
R2354 T8307 T8306 punct -,NT
R2355 T8308 T8306 nummod 3,NT
R2356 T8309 T8310 punct (,15
R2357 T8310 T8277 parataxis 15,set
R2358 T8311 T8310 nsubj n,15
R2359 T8312 T8310 punct =,15
R2360 T8313 T8310 punct ),15
R2361 T8314 T8277 punct .,set
R2362 T8316 T8317 compound Control,cultures
R2363 T8317 T8318 nsubjpass cultures,set
R2364 T8319 T8318 auxpass were,set
R2365 T8320 T8318 advcl using,set
R2366 T8321 T8322 npadvmod PBS,loaded
R2367 T8322 T8324 amod loaded,beads
R2368 T8323 T8322 punct -,loaded
R2369 T8324 T8320 dobj beads,using
R2370 T8325 T8326 punct (,6
R2371 T8326 T8320 parataxis 6,using
R2372 T8327 T8326 nsubj n,6
R2373 T8328 T8326 punct =,6
R2374 T8329 T8326 punct ),6
R2375 T8330 T8318 punct .,set
R2376 T8332 T8333 compound DiI,labeling
R2377 T8333 T8334 nsubj labeling,revealed
R2378 T8335 T8333 prep through,labeling
R2379 T8336 T8337 det the,DRGs
R2380 T8337 T8335 pobj DRGs,through
R2381 T8338 T8339 amod numerous,fibers
R2382 T8339 T8334 dobj fibers,revealed
R2383 T8340 T8339 acl entering,fibers
R2384 T8341 T8342 det the,cord
R2385 T8342 T8340 dobj cord,entering
R2386 T8343 T8342 amod spinal,cord
R2387 T8344 T8340 prep at,entering
R2388 T8345 T8346 amod ectopic,regions
R2389 T8346 T8344 pobj regions,at
R2390 T8347 T8340 cc and,entering
R2391 T8348 T8340 conj growing,entering
R2392 T8349 T8348 prep towards,growing
R2393 T8350 T8351 det the,beads
R2394 T8351 T8349 pobj beads,towards
R2395 T8352 T8351 nmod NT,beads
R2396 T8353 T8352 punct -,NT
R2397 T8354 T8352 nummod 3,NT
R2398 T8355 T8356 punct (,6A
R2399 T8356 T8349 parataxis 6A,towards
R2400 T8357 T8356 compound Figure,6A
R2401 T8358 T8356 punct ),6A
R2402 T8359 T8340 punct ", ",entering
R2403 T8360 T8340 dep surrounding,entering
R2404 T8361 T8362 det the,beads
R2405 T8362 T8360 dobj beads,surrounding
R2406 T8363 T8360 cc and,surrounding
R2407 T8364 T8360 conj forming,surrounding
R2408 T8365 T8364 dobj bundles,forming
R2409 T8366 T8364 prep around,forming
R2410 T8367 T8366 pobj them,around
R2411 T8368 T8369 punct (,6C
R2412 T8369 T8334 parataxis 6C,revealed
R2413 T8370 T8369 compound Figure,6C
R2414 T8371 T8372 punct –,6E
R2415 T8372 T8369 prep 6E,6C
R2416 T8373 T8369 punct ),6C
R2417 T8374 T8334 punct .,revealed
R2418 T8376 T8377 prep In,directed
R2419 T8378 T8379 compound control,cultures
R2420 T8379 T8376 pobj cultures,In
R2421 T8380 T8377 punct ", ",directed
R2422 T8381 T8382 det all,fibers
R2423 T8382 T8377 nsubjpass fibers,directed
R2424 T8383 T8382 amod labeled,fibers
R2425 T8384 T8377 auxpass were,directed
R2426 T8385 T8377 prep towards,directed
R2427 T8386 T8387 det the,cord
R2428 T8387 T8385 pobj cord,towards
R2429 T8388 T8387 amod dorsal,cord
R2430 T8389 T8387 amod spinal,cord
R2431 T8390 T8377 cc and,directed
R2432 T8391 T8377 conj terminated,directed
R2433 T8392 T8391 advmod there,terminated
R2434 T8393 T8391 punct ", ",terminated
R2435 T8394 T8395 advmod where,enter
R2436 T8395 T8391 advcl enter,terminated
R2437 T8396 T8395 nsubj they,enter
R2438 T8397 T8395 advmod normally,enter
R2439 T8398 T8399 det the,matter
R2440 T8399 T8395 dobj matter,enter
R2441 T8400 T8399 amod gray,matter
R2442 T8401 T8395 prep at,enter
R2443 T8402 T8401 pobj E13,at
R2444 T8403 T8404 punct (,6B
R2445 T8404 T8391 parataxis 6B,terminated
R2446 T8405 T8404 compound Figure,6B
R2447 T8406 T8404 punct ),6B
R2448 T8407 T8377 punct .,directed
R2449 T8409 T8410 det No,axons
R2450 T8410 T8411 nsubjpass axons,observed
R2451 T8412 T8411 auxpass were,observed
R2452 T8413 T8411 prep around,observed
R2453 T8414 T8415 det the,beads
R2454 T8415 T8413 pobj beads,around
R2455 T8416 T8417 npadvmod PBS,loaded
R2456 T8417 T8415 amod loaded,beads
R2457 T8418 T8417 punct -,loaded
R2458 T8419 T8415 compound control,beads
R2459 T8420 T8421 punct (,6F
R2460 T8421 T8411 parataxis 6F,observed
R2461 T8422 T8421 compound Figure,6F
R2462 T8423 T8421 punct ),6F
R2463 T8424 T8411 punct .,observed
R2464 T8426 T8427 nsubj Axons,grow
R2465 T8428 T8429 dep that,enter
R2466 T8429 T8426 relcl enter,Axons
R2467 T8430 T8429 advmod normally,enter
R2468 T8431 T8432 det the,matter
R2469 T8432 T8429 dobj matter,enter
R2470 T8433 T8432 amod gray,matter
R2471 T8434 T8429 prep through,enter
R2472 T8435 T8436 amod dorsal,cord
R2473 T8436 T8434 pobj cord,through
R2474 T8437 T8436 amod spinal,cord
R2475 T8438 T8427 prep towards,grow
R2476 T8439 T8440 det the,midline
R2477 T8440 T8438 pobj midline,towards
R2478 T8441 T8442 advmod when,presented
R2479 T8442 T8427 advcl presented,grow
R2480 T8443 T8442 prep with,presented
R2481 T8444 T8445 det a,source
R2482 T8445 T8443 pobj source,with
R2483 T8446 T8445 amod localized,source
R2484 T8447 T8445 nmod NT,source
R2485 T8448 T8447 punct -,NT
R2486 T8449 T8447 nummod 3,NT
R2487 T8450 T8427 punct ", ",grow
R2488 T8451 T8427 cc and,grow
R2489 T8452 T8453 amod new,growth
R2490 T8453 T8455 nsubjpass growth,initiated
R2491 T8454 T8453 compound axon,growth
R2492 T8455 T8427 conj initiated,grow
R2493 T8456 T8453 prep towards,growth
R2494 T8457 T8458 det the,bead
R2495 T8458 T8456 pobj bead,towards
R2496 T8459 T8458 nmod NT,bead
R2497 T8460 T8459 punct -,NT
R2498 T8461 T8459 nummod 3,NT
R2499 T8462 T8455 auxpass is,initiated
R2500 T8463 T8455 prep from,initiated
R2501 T8464 T8463 pobj DRGs,from
R2502 T8465 T8455 punct ", ",initiated
R2503 T8466 T8455 advcl entering,initiated
R2504 T8467 T8468 det the,cord
R2505 T8468 T8466 dobj cord,entering
R2506 T8469 T8468 amod spinal,cord
R2507 T8470 T8466 prep at,entering
R2508 T8471 T8472 amod ectopic,loci
R2509 T8472 T8470 pobj loci,at
R2510 T8473 T8466 prep at,entering
R2511 T8474 T8475 amod lateral,cord
R2512 T8475 T8473 pobj cord,at
R2513 T8476 T8475 amod mid-spinal,cord
R2514 T8477 T8478 punct (,6G
R2515 T8478 T8466 parataxis 6G,entering
R2516 T8479 T8478 compound Figure,6G
R2517 T8480 T8478 punct ),6G
R2518 T8481 T8455 punct .,initiated
R2519 T8483 T8484 nsubj NT,is
R2520 T8485 T8483 punct -,NT
R2521 T8486 T8483 nummod 3,NT
R2522 T8487 T8484 advmod therefore,is
R2523 T8488 T8484 acomp capable,is
R2524 T8489 T8488 prep of,capable
R2525 T8490 T8489 pcomp acting,of
R2526 T8491 T8490 prep as,acting
R2527 T8492 T8493 det a,chemoattractant
R2528 T8493 T8491 pobj chemoattractant,as
R2529 T8494 T8493 prep for,chemoattractant
R2530 T8495 T8496 compound DRG,axons
R2531 T8496 T8494 pobj axons,for
R2532 T8497 T8484 punct .,is
R444 T2324 T2325 npadvmod TrkC,Positive
R445 T2325 T2327 amod Positive,Neurons
R446 T2326 T2325 punct -,Positive
R447 T2327 T2329 nsubjpass Neurons,Rescued
R448 T2328 T2327 compound DRG,Neurons
R449 T2330 T2329 auxpass Are,Rescued
R450 T2331 T2329 prep in,Rescued
R451 T2332 T2333 nmod Bax,Knockout
R452 T2333 T2339 compound Knockout,Mice
R453 T2334 T2332 punct /,Bax
R454 T2335 T2332 appos NT,Bax
R455 T2336 T2335 punct -,NT
R456 T2337 T2335 nummod 3,NT
R457 T2338 T2333 amod Double,Knockout
R458 T2339 T2331 pobj Mice,in
R459 T2341 T2342 nsubj Mice,allow
R460 T2343 T2341 acl lacking,Mice
R461 T2344 T2345 amod proapoptotic,Bax
R462 T2345 T2343 dobj Bax,lacking
R463 T2346 T2345 compound protein,Bax
R464 T2347 T2342 prep for,allow
R465 T2348 T2347 pcomp distinguishing,for
R466 T2349 T2350 compound survival,effects
R467 T2350 T2348 dobj effects,distinguishing
R468 T2351 T2350 prep of,effects
R469 T2352 T2351 pobj neurotrophins,of
R470 T2353 T2348 prep from,distinguishing
R471 T2354 T2355 amod other,effects
R472 T2355 T2353 pobj effects,from
R473 T2356 T2342 punct .,allow
R474 T2358 T2359 npadvmod Bax,deficient
R475 T2359 T2361 amod deficient,neurons
R476 T2360 T2359 punct -,deficient
R477 T2361 T2363 nsubj neurons,require
R478 T2362 T2361 amod sensory,neurons
R479 T2363 T2366 ccomp require,used
R480 T2364 T2365 neg no,longer
R481 T2365 T2363 advmod longer,require
R482 T2367 T2363 dobj neurotrophins,require
R483 T2368 T2363 prep for,require
R484 T2369 T2368 pobj survival,for
R485 T2370 T2371 punct (,White
R486 T2371 T2363 meta White,require
R487 T2372 T2371 nmod et,White
R488 T2373 T2371 nmod al.,White
R489 T2374 T2371 nummod 1998,White
R490 T2375 T2371 punct ;,White
R491 T2376 T2371 nmod Patel,White
R492 T2377 T2371 nmod et,White
R493 T2378 T2371 nmod al.,White
R494 T2379 T2371 nummod 2000,White
R495 T2380 T2371 punct ),White
R496 T2381 T2366 punct ", ",used
R497 T2382 T2366 advmod thus,used
R498 T2383 T2366 nsubjpass they,used
R499 T2384 T2366 aux can,used
R500 T2385 T2366 auxpass be,used
R501 T2386 T2387 aux to,examine
R502 T2387 T2366 advcl examine,used
R503 T2388 T2389 amod axonal,effects
R504 T2389 T2387 dobj effects,examine
R505 T2390 T2366 punct .,used
R506 T2392 T2393 nsubj We,bred
R507 T2394 T2395 nmod NT,heterozygote
R508 T2395 T2393 dobj heterozygote,bred
R509 T2396 T2394 punct -,NT
R510 T2397 T2394 nummod 3,NT
R511 T2398 T2395 cc and,heterozygote
R512 T2399 T2400 nmod Bax,knockout
R513 T2400 T2401 nmod knockout,mice
R514 T2401 T2395 conj mice,heterozygote
R515 T2402 T2400 punct (,knockout
R516 T2403 T2400 appos KO,knockout
R517 T2404 T2401 punct ),mice
R518 T2405 T2406 aux to,obtain
R519 T2406 T2393 advcl obtain,bred
R520 T2407 T2406 dobj mice,obtain
R521 T2408 T2407 prep with,mice
R522 T2409 T2410 amod double,KO
R523 T2410 T2408 pobj KO,with
R524 T2411 T2410 prep of,KO
R525 T2412 T2413 preconj both,NT
R526 T2413 T2414 nmod NT,genes
R527 T2414 T2411 pobj genes,of
R528 T2415 T2413 punct -,NT
R529 T2416 T2413 nummod 3,NT
R530 T2417 T2413 cc and,NT
R531 T2418 T2413 conj Bax,NT
R532 T2419 T2393 punct ", ",bred
R533 T2420 T2393 cc and,bred
R534 T2421 T2393 conj examined,bred
R535 T2422 T2423 amod proprioceptive,projections
R536 T2423 T2421 dobj projections,examined
R537 T2424 T2423 amod axonal,projections
R538 T2425 T2393 punct .,bred
R539 T2427 T2428 det All,KOs
R540 T2428 T2434 nsubj KOs,died
R541 T2429 T2428 nmod NT,KOs
R542 T2430 T2429 punct -,NT
R543 T2431 T2429 nummod 3,NT
R544 T2432 T2429 cc and,NT
R545 T2433 T2429 conj double,NT
R546 T2435 T2434 prep within,died
R547 T2436 T2437 nummod 48,h
R548 T2437 T2435 pobj h,within
R549 T2438 T2437 prep after,h
R550 T2439 T2438 pobj birth,after
R551 T2440 T2441 punct (,Tessarollo
R552 T2441 T2434 meta Tessarollo,died
R553 T2442 T2441 nmod et,Tessarollo
R554 T2443 T2441 nmod al.,Tessarollo
R555 T2444 T2441 nummod 1994,Tessarollo
R556 T2445 T2441 punct ),Tessarollo
R557 T2446 T2434 punct .,died
R558 T2448 T2449 nsubj We,performed
R559 T2450 T2451 nmod TrkA,TrkC
R560 T2451 T2453 nmod TrkC,immunohistochemistry
R561 T2452 T2451 punct /,TrkC
R562 T2453 T2449 dobj immunohistochemistry,performed
R563 T2454 T2453 amod double,immunohistochemistry
R564 T2455 T2456 punct (,Huang
R565 T2456 T2453 meta Huang,immunohistochemistry
R566 T2457 T2456 nmod et,Huang
R567 T2458 T2456 nmod al.,Huang
R568 T2459 T2456 nummod 1999,Huang
R569 T2460 T2456 punct ),Huang
R570 T2461 T2449 punct ", ",performed
R571 T2462 T2449 advcl enabling,performed
R572 T2463 T2462 dobj detection,enabling
R573 T2464 T2463 prep of,detection
R574 T2465 T2466 det both,proteins
R575 T2466 T2464 pobj proteins,of
R576 T2467 T2462 prep in,enabling
R577 T2468 T2469 det the,sample
R578 T2469 T2467 pobj sample,in
R579 T2470 T2469 amod same,sample
R580 T2471 T2449 punct .,performed
R581 T2473 T2474 npadvmod TrkC,positive
R582 T2474 T2476 amod positive,cells
R583 T2475 T2474 punct -,positive
R584 T2476 T2477 nsubj cells,were
R585 T2478 T2479 punct (,1A
R586 T2479 T2476 parataxis 1A,cells
R587 T2480 T2479 compound Figure,1A
R588 T2481 T2479 punct ),1A
R589 T2482 T2476 cc and,cells
R590 T2483 T2476 conj fibers,cells
R591 T2484 T2485 punct (,1E
R592 T2485 T2483 parataxis 1E,fibers
R593 T2486 T2485 compound Figure,1E
R594 T2487 T2485 punct ),1E
R595 T2488 T2477 acomp absent,were
R596 T2489 T2477 prep in,were
R597 T2490 T2491 nmod NT,KOs
R598 T2491 T2489 pobj KOs,in
R599 T2492 T2490 punct -,NT
R600 T2493 T2490 nummod 3,NT
R601 T2494 T2477 prep at,were
R602 T2495 T2496 amod embryonic,day
R603 T2496 T2494 pobj day,at
R604 T2497 T2496 punct (,day
R605 T2498 T2496 appos E,day
R606 T2499 T2496 punct ),day
R607 T2500 T2496 nummod 15,day
R608 T2501 T2477 punct .,were
R609 T2503 T2504 nummod Two,subsets
R610 T2504 T2505 nsubjpass subsets,detected
R611 T2506 T2504 prep of,subsets
R612 T2507 T2508 compound DRG,cells
R613 T2508 T2506 pobj cells,of
R614 T2509 T2504 acl expressing,subsets
R615 T2510 T2511 preconj either,TrkA
R616 T2511 T2509 dobj TrkA,expressing
R617 T2512 T2511 cc or,TrkA
R618 T2513 T2511 conj TrkC,TrkA
R619 T2514 T2505 auxpass were,detected
R620 T2515 T2505 prep in,detected
R621 T2516 T2517 amod double,KOs
R622 T2517 T2515 pobj KOs,in
R623 T2518 T2505 punct ", ",detected
R624 T2519 T2505 advcl similar,detected
R625 T2520 T2519 prep to,similar
R626 T2521 T2522 amod wild,type
R627 T2522 T2524 nmod type,animals
R628 T2523 T2522 punct -,type
R629 T2524 T2520 pobj animals,to
R630 T2525 T2522 punct (,type
R631 T2526 T2522 appos WT,type
R632 T2527 T2522 punct ),type
R633 T2528 T2522 cc or,type
R634 T2529 T2530 compound Bax,KO
R635 T2530 T2522 conj KO,type
R636 T2531 T2505 punct .,detected
R637 T2533 T2534 advmod Surprisingly,expressed
R638 T2535 T2534 punct ", ",expressed
R639 T2536 T2534 prep at,expressed
R640 T2537 T2538 amod postnatal,day
R641 T2538 T2536 pobj day,at
R642 T2539 T2538 punct (,day
R643 T2540 T2538 appos P,day
R644 T2541 T2538 punct ),day
R645 T2542 T2538 nummod 0,day
R646 T2543 T2534 punct ", ",expressed
R647 T2544 T2545 det a,cells
R648 T2545 T2534 nsubj cells,expressed
R649 T2546 T2545 amod few,cells
R650 T2547 T2534 dobj TrkC,expressed
R651 T2548 T2549 advmod even,in
R652 T2549 T2534 prep in,expressed
R653 T2550 T2551 nmod NT,KO
R654 T2551 T2554 compound KO,animals
R655 T2552 T2550 punct -,NT
R656 T2553 T2550 nummod 3,NT
R657 T2554 T2549 pobj animals,in
R658 T2555 T2554 prep in,animals
R659 T2556 T2557 det the,background
R660 T2557 T2555 pobj background,in
R661 T2558 T2557 nmod Bax,background
R662 T2559 T2558 punct +,Bax
R663 T2560 T2558 punct /,Bax
R664 T2561 T2558 punct +,Bax
R665 T2562 T2557 amod genetic,background
R666 T2563 T2534 punct ", ",expressed
R667 T2564 T2534 cc and,expressed
R668 T2565 T2566 det some,cells
R669 T2566 T2567 nsubj cells,co-expressed
R670 T2567 T2534 conj co-expressed,expressed
R671 T2568 T2567 dobj TrkA,co-expressed
R672 T2569 T2568 cc and,TrkA
R673 T2570 T2568 conj TrkC,TrkA
R674 T2571 T2567 punct ", ",co-expressed
R675 T2572 T2567 advmod regardless,co-expressed
R676 T2573 T2572 prep of,regardless
R677 T2574 T2575 det the,genotype
R678 T2575 T2573 pobj genotype,of
R679 T2576 T2577 punct (,1B
R680 T2577 T2567 parataxis 1B,co-expressed
R681 T2578 T2577 compound Figure,1B
R682 T2579 T2577 punct ),1B
R683 T2580 T2534 punct .,expressed
R684 T2582 T2583 prep In,analyzed
R685 T2584 T2582 pobj order,In
R686 T2585 T2586 aux to,quantify
R687 T2586 T2584 acl quantify,order
R688 T2587 T2588 poss our,results
R689 T2588 T2586 dobj results,quantify
R690 T2589 T2583 punct ", ",analyzed
R691 T2590 T2583 nsubj we,analyzed
R692 T2591 T2592 det the,ratio
R693 T2592 T2583 dobj ratio,analyzed
R694 T2593 T2592 prep of,ratio
R695 T2594 T2595 npadvmod TrkA,immunopositive
R696 T2595 T2598 amod immunopositive,cells
R697 T2596 T2594 cc and,TrkA
R698 T2597 T2594 conj TrkC,TrkA
R699 T2598 T2593 pobj cells,of
R700 T2599 T2598 prep from,cells
R701 T2600 T2601 nummod four,DRGs
R702 T2601 T2599 pobj DRGs,from
R703 T2602 T2601 amod different,DRGs
R704 T2603 T2601 prep of,DRGs
R705 T2604 T2603 pobj animals,of
R706 T2605 T2604 prep of,animals
R707 T2606 T2607 amod different,genotypes
R708 T2607 T2605 pobj genotypes,of
R709 T2608 T2583 punct .,analyzed
R710 T2610 T2611 prep At,had
R711 T2612 T2613 det all,ages
R712 T2613 T2610 pobj ages,At
R713 T2614 T2613 acl studied,ages
R714 T2615 T2611 punct ", ",had
R715 T2616 T2617 npadvmod Bax,null
R716 T2617 T2623 amod null,DRGs
R717 T2618 T2616 punct /,Bax
R718 T2619 T2616 appos NT,Bax
R719 T2620 T2619 punct -,NT
R720 T2621 T2619 nummod 3,NT
R721 T2622 T2617 amod double,null
R722 T2623 T2611 nsubj DRGs,had
R723 T2624 T2625 compound TrkA,TrkC
R724 T2625 T2627 compound TrkC,ratios
R725 T2626 T2625 punct /,TrkC
R726 T2627 T2611 dobj ratios,had
R727 T2628 T2627 amod similar,ratios
R728 T2629 T2628 prep to,similar
R729 T2630 T2629 pobj those,to
R730 T2631 T2630 prep of,those
R731 T2632 T2633 npadvmod Bax,null
R732 T2633 T2634 amod null,DRGs
R733 T2634 T2631 pobj DRGs,of
R734 T2635 T2628 punct ", ",similar
R735 T2636 T2628 cc and,similar
R736 T2637 T2628 conj higher,similar
R737 T2638 T2637 prep than,higher
R738 T2639 T2638 pobj those,than
R739 T2640 T2639 prep of,those
R740 T2641 T2642 npadvmod NT,null
R741 T2642 T2645 amod null,DRGs
R742 T2643 T2641 punct -,NT
R743 T2644 T2641 nummod 3,NT
R744 T2645 T2640 pobj DRGs,of
R745 T2646 T2647 punct (,1D
R746 T2647 T2611 parataxis 1D,had
R747 T2648 T2647 compound Figure,1D
R748 T2649 T2647 punct ),1D
R749 T2650 T2611 punct .,had
R750 T2652 T2653 npadvmod TrkC,positive
R751 T2653 T2655 amod positive,neurons
R752 T2654 T2653 punct -,positive
R753 T2655 T2656 nsubj neurons,failed
R754 T2657 T2655 acl rescued,neurons
R755 T2658 T2657 prep by,rescued
R756 T2659 T2660 compound Bax,deletion
R757 T2660 T2658 pobj deletion,by
R758 T2661 T2656 punct ", ",failed
R759 T2662 T2656 advmod however,failed
R760 T2663 T2656 punct ", ",failed
R761 T2664 T2665 aux to,differentiate
R762 T2665 T2656 xcomp differentiate,failed
R763 T2666 T2665 advmod properly,differentiate
R764 T2667 T2665 punct ", ",differentiate
R765 T2668 T2669 mark as,evidenced
R766 T2669 T2665 advcl evidenced,differentiate
R767 T2670 T2669 prep by,evidenced
R768 T2671 T2672 det the,lack
R769 T2672 T2670 pobj lack,by
R770 T2673 T2672 prep of,lack
R771 T2674 T2673 pobj expression,of
R772 T2675 T2674 prep of,expression
R773 T2676 T2677 det the,marker
R774 T2677 T2675 pobj marker,of
R775 T2678 T2677 amod proprioceptive,marker
R776 T2679 T2677 amod molecular,marker
R777 T2680 T2677 appos Parvalbumin,marker
R778 T2681 T2677 punct (,marker
R779 T2682 T2677 appos PV,marker
R780 T2683 T2656 punct ),failed
R781 T2684 T2685 punct (,1C
R782 T2685 T2656 parataxis 1C,failed
R783 T2686 T2685 compound Figure,1C
R784 T2687 T2685 punct ),1C
R785 T2688 T2656 punct .,failed
R790 T3969 T3970 nsubj NT,Is
R791 T3971 T3969 punct -,NT
R792 T3972 T3969 nummod 3,NT
R793 T3973 T3970 acomp Necessary,Is
R794 T3974 T3973 prep for,Necessary
R795 T3975 T3976 amod Proper,Innervation
R796 T3976 T3974 pobj Innervation,for
R797 T3977 T3976 prep of,Innervation
R798 T3978 T3979 amod Motor,Neurons
R799 T3979 T3977 pobj Neurons,of
R800 T3981 T3982 compound TrkA,TrkC
R801 T3982 T3984 npadvmod TrkC,positive
R802 T3983 T3982 punct /,TrkC
R803 T3984 T3986 amod positive,fibers
R804 T3985 T3984 punct -,positive
R805 T3986 T3987 nsubjpass fibers,detected
R806 T3988 T3986 prep in,fibers
R807 T3989 T3990 det the,cord
R808 T3990 T3988 pobj cord,in
R809 T3991 T3990 amod spinal,cord
R810 T3992 T3987 aux could,detected
R811 T3993 T3987 auxpass be,detected
R812 T3994 T3987 prep at,detected
R813 T3995 T3994 pobj E15,at
R814 T3996 T3997 punct (,1E
R815 T3997 T3987 parataxis 1E,detected
R816 T3998 T3997 compound Figure,1E
R817 T3999 T3997 punct ),1E
R818 T4000 T3987 punct .,detected
R819 T4002 T4003 npadvmod TrkA,positive
R820 T4003 T4005 amod positive,fibers
R821 T4004 T4003 punct -,positive
R822 T4005 T4006 nsubj fibers,restricted
R823 T4007 T4006 aux were,restricted
R824 T4008 T4006 prep to,restricted
R825 T4009 T4006 cc and,restricted
R826 T4010 T4006 conj terminated,restricted
R827 T4011 T4010 prep in,terminated
R828 T4012 T4013 det the,cord
R829 T4013 T4010 dobj cord,terminated
R830 T4014 T4013 amod dorsolateral,cord
R831 T4015 T4013 amod spinal,cord
R832 T4016 T4006 punct ", ",restricted
R833 T4017 T4018 mark whereas,entered
R834 T4018 T4006 advcl entered,restricted
R835 T4019 T4020 npadvmod TrkC,positive
R836 T4020 T4022 amod positive,fibers
R837 T4021 T4020 punct -,positive
R838 T4022 T4018 nsubj fibers,entered
R839 T4023 T4024 det the,cord
R840 T4024 T4018 dobj cord,entered
R841 T4025 T4018 advmod dorsomedially,entered
R842 T4026 T4018 punct ", ",entered
R843 T4027 T4018 cc and,entered
R844 T4028 T4018 conj descended,entered
R845 T4029 T4028 prep into,descended
R846 T4030 T4031 det the,horns
R847 T4031 T4029 pobj horns,into
R848 T4032 T4031 amod ventral,horns
R849 T4033 T4031 prep in,horns
R850 T4034 T4035 nmod WT,embryos
R851 T4035 T4033 pobj embryos,in
R852 T4036 T4037 punct (,Ozaki
R853 T4037 T4034 meta Ozaki,WT
R854 T4038 T4037 cc and,Ozaki
R855 T4039 T4037 conj Snider,Ozaki
R856 T4040 T4039 nummod 1997,Snider
R857 T4041 T4039 punct ),Snider
R858 T4042 T4034 cc and,WT
R859 T4043 T4044 compound Bax,KO
R860 T4044 T4034 conj KO,WT
R861 T4045 T4006 punct .,restricted
R862 T4047 T4048 expl There,was
R863 T4049 T4050 det no,expression
R864 T4050 T4048 attr expression,was
R865 T4051 T4050 amod detectable,expression
R866 T4052 T4050 compound TrkC,expression
R867 T4053 T4048 prep in,was
R868 T4054 T4055 nmod NT,KO
R869 T4055 T4058 nmod KO,cord
R870 T4056 T4054 punct -,NT
R871 T4057 T4054 nummod 3,NT
R872 T4058 T4053 pobj cord,in
R873 T4059 T4058 amod spinal,cord
R874 T4060 T4048 punct ", ",was
R875 T4061 T4048 advcl indicating,was
R876 T4062 T4063 amod complete,absence
R877 T4063 T4061 dobj absence,indicating
R878 T4064 T4063 prep of,absence
R879 T4065 T4066 amod proprioceptive,fibers
R880 T4066 T4064 pobj fibers,of
R881 T4067 T4048 punct .,was
R882 T4069 T4070 prep In,entered
R883 T4071 T4072 amod double,KO
R884 T4072 T4073 nmod KO,cord
R885 T4073 T4069 pobj cord,In
R886 T4074 T4073 amod spinal,cord
R887 T4075 T4070 punct ", ",entered
R888 T4076 T4077 npadvmod TrkC,positive
R889 T4077 T4079 amod positive,fibers
R890 T4078 T4077 punct -,positive
R891 T4079 T4070 nsubj fibers,entered
R892 T4080 T4081 det the,cord
R893 T4081 T4070 dobj cord,entered
R894 T4082 T4081 amod dorsal,cord
R895 T4083 T4081 amod spinal,cord
R896 T4084 T4070 cc and,entered
R897 T4085 T4070 conj descended,entered
R898 T4086 T4085 advmod medially,descended
R899 T4087 T4085 prep in,descended
R900 T4088 T4089 det a,manner
R901 T4089 T4087 pobj manner,in
R902 T4090 T4089 amod similar,manner
R903 T4091 T4090 prep to,similar
R904 T4092 T4091 pobj that,to
R905 T4093 T4092 acl seen,that
R906 T4094 T4093 prep in,seen
R907 T4095 T4096 nmod WT,cases
R908 T4096 T4094 pobj cases,in
R909 T4097 T4095 cc or,WT
R910 T4098 T4099 compound Bax,KO
R911 T4099 T4095 conj KO,WT
R912 T4100 T4070 punct .,entered
R913 T4102 T4103 advmod However,was
R914 T4104 T4103 punct ", ",was
R915 T4105 T4103 nsubj it,was
R916 T4106 T4103 neg not,was
R917 T4107 T4103 acomp possible,was
R918 T4108 T4109 aux to,follow
R919 T4109 T4103 xcomp follow,was
R920 T4110 T4111 nmod TrkC,fibers
R921 T4111 T4109 dobj fibers,follow
R922 T4112 T4111 amod immunolabeled,fibers
R923 T4113 T4114 predet all,way
R924 T4114 T4116 npadvmod way,to
R925 T4115 T4114 det the,way
R926 T4116 T4109 prep to,follow
R927 T4117 T4118 poss their,zones
R928 T4118 T4116 pobj zones,to
R929 T4119 T4118 amod terminal,zones
R930 T4120 T4109 prep in,follow
R931 T4121 T4120 pobj any,in
R932 T4122 T4121 prep of,any
R933 T4123 T4124 det the,cases
R934 T4124 T4122 pobj cases,of
R935 T4125 T4103 punct .,was
R936 T4127 T4128 advmod Next,examined
R937 T4129 T4128 nsubj we,examined
R938 T4130 T4131 det the,projections
R939 T4131 T4128 dobj projections,examined
R940 T4132 T4131 amod central,projections
R941 T4133 T4131 prep of,projections
R942 T4134 T4135 compound DRG,axons
R943 T4135 T4133 pobj axons,of
R944 T4136 T4128 prep with,examined
R945 T4137 T4138 det the,tracer
R946 T4138 T4136 pobj tracer,with
R947 T4139 T4138 amod lipophilic,tracer
R948 T4140 T4138 appos DiI,tracer
R949 T4141 T4128 prep at,examined
R950 T4142 T4141 pobj P0,at
R951 T4143 T4128 punct .,examined
R952 T4145 T4146 prep In,entered
R953 T4147 T4148 nmod WT,pups
R954 T4148 T4145 pobj pups,In
R955 T4149 T4147 cc and,WT
R956 T4150 T4151 compound Bax,KO
R957 T4151 T4147 conj KO,WT
R958 T4152 T4146 punct ", ",entered
R959 T4153 T4154 amod proprioceptive,afferents
R960 T4154 T4146 nsubj afferents,entered
R961 T4155 T4156 det the,cord
R962 T4156 T4146 dobj cord,entered
R963 T4157 T4156 amod dorsal,cord
R964 T4158 T4156 amod spinal,cord
R965 T4159 T4146 cc and,entered
R966 T4160 T4146 conj followed,entered
R967 T4161 T4162 det a,course
R968 T4162 T4160 dobj course,followed
R969 T4163 T4162 amod medial,course
R970 T4164 T4162 prep towards,course
R971 T4165 T4166 det the,horn
R972 T4166 T4164 pobj horn,towards
R973 T4167 T4166 amod ventral,horn
R974 T4168 T4146 punct .,entered
R975 T4170 T4171 nsubj They,turned
R976 T4172 T4171 advmod then,turned
R977 T4173 T4171 advmod laterally,turned
R978 T4174 T4171 prep towards,turned
R979 T4175 T4176 compound motor,neurons
R980 T4176 T4174 pobj neurons,towards
R981 T4177 T4176 prep in,neurons
R982 T4178 T4179 det the,column
R983 T4179 T4177 pobj column,in
R984 T4180 T4179 amod lateral,column
R985 T4181 T4179 compound motor,column
R986 T4182 T4179 punct ", ",column
R987 T4183 T4184 advmod where,branched
R988 T4184 T4179 relcl branched,column
R989 T4185 T4184 nsubj they,branched
R990 T4186 T4184 cc and,branched
R991 T4187 T4184 conj terminated,branched
R992 T4188 T4189 punct (,2A
R993 T4189 T4171 parataxis 2A,turned
R994 T4190 T4189 compound Figure,2A
R995 T4191 T4189 punct ),2A
R996 T4192 T4171 punct .,turned
R997 T4194 T4195 compound DiI,labeling
R998 T4195 T4196 nsubjpass labeling,confined
R999 T4197 T4196 auxpass was,confined