PMC:529315 JSON TXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id	Subject	Object	Predicate	Lexical cue
T408	0-1	DT	denotes	A
T410	0-63	sentence	denotes	A Chemoattractant Role for NT-3 in Proprioceptive Axon Guidance
T411	2-17	NN	denotes	Chemoattractant
T409	18-22	NN	denotes	Role
T412	23-26	IN	denotes	for
T413	27-29	NN	denotes	NT
T414	29-30	HYPH	denotes	-
T415	30-31	CD	denotes	3
T416	32-34	IN	denotes	in
T417	35-49	NN	denotes	Proprioceptive
T418	50-54	NN	denotes	Axon
T419	55-63	NN	denotes	Guidance
T420	63-64	sentence	denotes
T423	64-124	NN	denotes	NT-3 and Proprioceptive Axon Guidance Abstract Neurotrophin
T422	64-181	sentence	denotes	NT-3 and Proprioceptive Axon Guidance Abstract Neurotrophin-3 (NT-3) is required for proprioceptive neuron survival.
T425	124-125	HYPH	denotes	-
T426	125-126	CD	denotes	3
T427	127-128	-LRB-	denotes	(
T428	128-130	NN	denotes	NT
T429	130-131	HYPH	denotes	-
T430	131-132	CD	denotes	3
T431	132-133	-RRB-	denotes	)
T432	134-136	VBZ	denotes	is
T424	137-145	VBN	denotes	required
T433	146-149	IN	denotes	for
T434	150-164	JJ	denotes	proprioceptive
T435	165-171	NN	denotes	neuron
T436	172-180	NN	denotes	survival
T437	180-181	.	denotes	.
T438	181-345	sentence	denotes	Deletion of the proapoptotic gene Bax in NT-3 knockout mice rescues these neurons and allows for examination of their axon growth in the absence of NT-3 signaling.
T439	182-190	NN	denotes	Deletion
T441	191-193	IN	denotes	of
T442	194-197	DT	denotes	the
T444	198-210	JJ	denotes	proapoptotic
T443	211-215	NN	denotes	gene
T445	216-219	NN	denotes	Bax
T446	220-222	IN	denotes	in
T447	223-225	NN	denotes	NT
T449	225-226	HYPH	denotes	-
T450	226-227	CD	denotes	3
T448	228-236	NN	denotes	knockout
T451	237-241	NNS	denotes	mice
T440	242-249	VBZ	denotes	rescues
T452	250-255	DT	denotes	these
T453	256-263	NNS	denotes	neurons
T454	264-267	CC	denotes	and
T455	268-274	VBZ	denotes	allows
T456	275-278	IN	denotes	for
T457	279-290	NN	denotes	examination
T458	291-293	IN	denotes	of
T459	294-299	PRP$	denotes	their
T461	300-304	NN	denotes	axon
T460	305-311	NN	denotes	growth
T462	312-314	IN	denotes	in
T463	315-318	DT	denotes	the
T464	319-326	NN	denotes	absence
T465	327-329	IN	denotes	of
T466	330-332	NN	denotes	NT
T468	332-333	HYPH	denotes	-
T469	333-334	CD	denotes	3
T467	335-344	NN	denotes	signaling
T470	344-345	.	denotes	.
T471	345-515	sentence	denotes	TrkC-positive peripheral and central axons from dorsal root ganglia follow proper trajectories and arrive in close proximity to their targets but fail to innervate them.
T472	346-350	NN	denotes	TrkC
T474	350-351	HYPH	denotes	-
T473	351-359	JJ	denotes	positive
T476	360-370	JJ	denotes	peripheral
T477	371-374	CC	denotes	and
T478	375-382	JJ	denotes	central
T475	383-388	NNS	denotes	axons
T480	389-393	IN	denotes	from
T481	394-400	JJ	denotes	dorsal
T482	401-405	NN	denotes	root
T483	406-413	NNS	denotes	ganglia
T479	414-420	VBP	denotes	follow
T484	421-427	JJ	denotes	proper
T485	428-440	NNS	denotes	trajectories
T486	441-444	CC	denotes	and
T487	445-451	VBP	denotes	arrive
T488	452-454	IN	denotes	in
T489	455-460	JJ	denotes	close
T490	461-470	NN	denotes	proximity
T491	471-473	IN	denotes	to
T492	474-479	PRP$	denotes	their
T493	480-487	NNS	denotes	targets
T494	488-491	CC	denotes	but
T495	492-496	VBP	denotes	fail
T496	497-499	TO	denotes	to
T497	500-509	VB	denotes	innervate
T498	510-514	PRP	denotes	them
T499	514-515	.	denotes	.
T500	515-615	sentence	denotes	Peripherally, muscle spindles are absent and TrkC-positive axons do not enter their target muscles.
T501	516-528	RB	denotes	Peripherally
T503	528-530	,	denotes	,
T504	530-536	NN	denotes	muscle
T505	537-545	NNS	denotes	spindles
T502	546-549	VBP	denotes	are
T506	550-556	JJ	denotes	absent
T507	557-560	CC	denotes	and
T508	561-565	NN	denotes	TrkC
T510	565-566	HYPH	denotes	-
T509	566-574	JJ	denotes	positive
T511	575-580	NNS	denotes	axons
T513	581-583	VBP	denotes	do
T514	584-587	RB	denotes	not
T512	588-593	VB	denotes	enter
T515	594-599	PRP$	denotes	their
T517	600-606	NN	denotes	target
T516	607-614	NNS	denotes	muscles
T518	614-615	.	denotes	.
T519	615-720	sentence	denotes	Centrally, proprioceptive axons branch in ectopic regions of the spinal cord, even crossing the midline.
T520	616-625	RB	denotes	Centrally
T522	625-627	,	denotes	,
T523	627-641	JJ	denotes	proprioceptive
T524	642-647	NNS	denotes	axons
T521	648-654	VBP	denotes	branch
T525	655-657	IN	denotes	in
T526	658-665	JJ	denotes	ectopic
T527	666-673	NNS	denotes	regions
T528	674-676	IN	denotes	of
T529	677-680	DT	denotes	the
T531	681-687	JJ	denotes	spinal
T530	688-692	NN	denotes	cord
T532	692-694	,	denotes	,
T533	694-698	RB	denotes	even
T534	699-707	VBG	denotes	crossing
T535	708-711	DT	denotes	the
T536	712-719	NN	denotes	midline
T537	719-720	.	denotes	.
T538	720-806	sentence	denotes	In vitro assays reveal chemoattractant effects of NT-3 on dorsal root ganglion axons.
T539	721-723	FW	denotes	In
T540	724-729	FW	denotes	vitro
T541	730-736	NNS	denotes	assays
T542	737-743	VBP	denotes	reveal
T543	744-759	NN	denotes	chemoattractant
T544	760-767	NNS	denotes	effects
T545	768-770	IN	denotes	of
T546	771-773	NN	denotes	NT
T547	773-774	HYPH	denotes	-
T548	774-775	CD	denotes	3
T549	776-778	IN	denotes	on
T550	779-785	JJ	denotes	dorsal
T551	786-790	NN	denotes	root
T552	791-799	NN	denotes	ganglion
T553	800-805	NNS	denotes	axons
T554	805-806	.	denotes	.
T555	806-965	sentence	denotes	Our results show that survival factor NT-3 acts as a short-distance axon guidance molecule for muscle sensory afferents as they approach their proper targets.
T556	807-810	PRP$	denotes	Our
T557	811-818	NNS	denotes	results
T558	819-823	VBP	denotes	show
T559	824-828	IN	denotes	that
T561	829-837	NN	denotes	survival
T562	838-844	NN	denotes	factor
T563	845-847	NN	denotes	NT
T564	847-848	HYPH	denotes	-
T565	848-849	CD	denotes	3
T560	850-854	VBZ	denotes	acts
T566	855-857	IN	denotes	as
T567	858-859	DT	denotes	a
T569	860-865	JJ	denotes	short
T571	865-866	HYPH	denotes	-
T570	866-874	NN	denotes	distance
T572	875-879	NN	denotes	axon
T573	880-888	NN	denotes	guidance
T568	889-897	NN	denotes	molecule
T574	898-901	IN	denotes	for
T575	902-908	NN	denotes	muscle
T577	909-916	NN	denotes	sensory
T576	917-926	NNS	denotes	afferents
T578	927-929	IN	denotes	as
T580	930-934	PRP	denotes	they
T579	935-943	VBP	denotes	approach
T581	944-949	PRP$	denotes	their
T583	950-956	JJ	denotes	proper
T582	957-964	NNS	denotes	targets
T584	964-965	.	denotes	.
T1178	1100-1112	NN	denotes	Neurotrophin
T1180	1112-1113	HYPH	denotes	-
T1181	1113-1114	CD	denotes	3
T1182	1115-1116	-LRB-	denotes	(
T1183	1116-1118	NN	denotes	NT
T1184	1118-1119	HYPH	denotes	-
T1185	1119-1120	CD	denotes	3
T1186	1120-1121	-RRB-	denotes	)
T1179	1122-1124	VBZ	denotes	is
T1187	1125-1126	DT	denotes	a
T1189	1127-1130	JJ	denotes	key
T1188	1131-1142	NN	denotes	requirement
T1190	1143-1146	IN	denotes	for
T1191	1147-1150	DT	denotes	the
T1192	1151-1162	NN	denotes	development
T1193	1163-1165	IN	denotes	of
T1194	1166-1180	JJ	denotes	proprioceptive
T1195	1181-1187	NNS	denotes	inputs
T1196	1188-1190	IN	denotes	to
T1197	1191-1196	JJ	denotes	motor
T1198	1197-1204	NNS	denotes	neurons
T1199	1205-1206	-LRB-	denotes	(
T1200	1206-1210	NNP	denotes	Chen
T1201	1211-1214	CC	denotes	and
T1202	1215-1220	NNP	denotes	Frank
T1203	1221-1225	CD	denotes	1999
T1204	1225-1226	:	denotes	;
T1205	1227-1231	NNP	denotes	Chen
T1206	1232-1234	FW	denotes	et
T1207	1235-1238	FW	denotes	al.
T1208	1239-1243	CD	denotes	2003
T1209	1243-1244	-RRB-	denotes	)
T1210	1244-1245	.	denotes	.
T1211	1245-1664	sentence	denotes	Mice deficient in NT-3, its tyrosine kinase receptor, TrkC, or in TrkC-positive neuron-specific transcription factor Runx3 display severe ataxia associated with the absence of muscle spindles, and loss of proprioceptive neurons in dorsal root ganglia (DRGs) or their axons (Ernfors et al. 1994; Klein et al. 1994; Tessarollo et al. 1994; Fariñas et al. 1996; Liebl et al. 1997; Inoue et al. 2002; Levanon et al. 2002).
T1212	1246-1250	NNS	denotes	Mice
T1214	1251-1260	JJ	denotes	deficient
T1215	1261-1263	IN	denotes	in
T1216	1264-1266	NN	denotes	NT
T1217	1266-1267	HYPH	denotes	-
T1218	1267-1268	CD	denotes	3
T1219	1268-1270	,	denotes	,
T1220	1270-1273	PRP$	denotes	its
T1222	1274-1282	NN	denotes	tyrosine
T1223	1283-1289	NN	denotes	kinase
T1221	1290-1298	NN	denotes	receptor
T1224	1298-1300	,	denotes	,
T1225	1300-1304	NN	denotes	TrkC
T1226	1304-1306	,	denotes	,
T1227	1306-1308	CC	denotes	or
T1228	1309-1311	IN	denotes	in
T1229	1312-1316	NN	denotes	TrkC
T1231	1316-1317	HYPH	denotes	-
T1230	1317-1325	JJ	denotes	positive
T1233	1326-1332	NN	denotes	neuron
T1234	1332-1333	HYPH	denotes	-
T1235	1333-1341	JJ	denotes	specific
T1236	1342-1355	NN	denotes	transcription
T1232	1356-1362	NN	denotes	factor
T1237	1363-1368	NN	denotes	Runx3
T1213	1369-1376	VBP	denotes	display
T1238	1377-1383	JJ	denotes	severe
T1239	1384-1390	NN	denotes	ataxia
T1240	1391-1401	VBN	denotes	associated
T1241	1402-1406	IN	denotes	with
T1242	1407-1410	DT	denotes	the
T1243	1411-1418	NN	denotes	absence
T1244	1419-1421	IN	denotes	of
T1245	1422-1428	NN	denotes	muscle
T1246	1429-1437	NNS	denotes	spindles
T1247	1437-1439	,	denotes	,
T1248	1439-1442	CC	denotes	and
T1249	1443-1447	NN	denotes	loss
T1250	1448-1450	IN	denotes	of
T1251	1451-1465	JJ	denotes	proprioceptive
T1252	1466-1473	NNS	denotes	neurons
T1253	1474-1476	IN	denotes	in
T1254	1477-1483	JJ	denotes	dorsal
T1255	1484-1488	NN	denotes	root
T1256	1489-1496	NNS	denotes	ganglia
T1257	1497-1498	-LRB-	denotes	(
T1258	1498-1502	NNS	denotes	DRGs
T1259	1502-1503	-RRB-	denotes	)
T1260	1504-1506	CC	denotes	or
T1261	1507-1512	PRP$	denotes	their
T1262	1513-1518	NNS	denotes	axons
T1263	1519-1520	-LRB-	denotes	(
T1264	1520-1527	NNP	denotes	Ernfors
T1265	1528-1530	FW	denotes	et
T1266	1531-1534	FW	denotes	al.
T1267	1535-1539	CD	denotes	1994
T1268	1539-1540	:	denotes	;
T1269	1541-1546	NNP	denotes	Klein
T1270	1547-1549	FW	denotes	et
T1271	1550-1553	FW	denotes	al.
T1272	1554-1558	CD	denotes	1994
T1273	1558-1559	:	denotes	;
T1274	1560-1570	NNP	denotes	Tessarollo
T1275	1571-1573	FW	denotes	et
T1276	1574-1577	FW	denotes	al.
T1277	1578-1582	CD	denotes	1994
T1278	1582-1583	:	denotes	;
T1279	1584-1591	NNP	denotes	Fariñas
T1280	1592-1594	FW	denotes	et
T1281	1595-1598	FW	denotes	al.
T1282	1599-1603	CD	denotes	1996
T1283	1603-1604	:	denotes	;
T1284	1605-1610	NNP	denotes	Liebl
T1285	1611-1613	FW	denotes	et
T1286	1614-1617	FW	denotes	al.
T1287	1618-1622	CD	denotes	1997
T1288	1622-1623	:	denotes	;
T1289	1624-1629	NNP	denotes	Inoue
T1290	1630-1632	FW	denotes	et
T1291	1633-1636	FW	denotes	al.
T1292	1637-1641	CD	denotes	2002
T1293	1641-1642	:	denotes	;
T1294	1643-1650	NNP	denotes	Levanon
T1295	1651-1653	FW	denotes	et
T1296	1654-1657	FW	denotes	al.
T1297	1658-1662	CD	denotes	2002
T1298	1662-1663	-RRB-	denotes	)
T1299	1663-1664	.	denotes	.
T1300	1664-1874	sentence	denotes	NT-3 is expressed in the ventral spinal cord, in the developing limb buds, and in intrafusal bag fibers of muscle spindles later in development (Copray and Brouwer 1994; Fariñas et al. 1996; Tojo et al. 1996).
T1301	1665-1667	NN	denotes	NT
T1303	1667-1668	HYPH	denotes	-
T1304	1668-1669	CD	denotes	3
T1305	1670-1672	VBZ	denotes	is
T1302	1673-1682	VBN	denotes	expressed
T1306	1683-1685	IN	denotes	in
T1307	1686-1689	DT	denotes	the
T1309	1690-1697	JJ	denotes	ventral
T1310	1698-1704	JJ	denotes	spinal
T1308	1705-1709	NN	denotes	cord
T1311	1709-1711	,	denotes	,
T1312	1711-1713	IN	denotes	in
T1313	1714-1717	DT	denotes	the
T1315	1718-1728	VBG	denotes	developing
T1316	1729-1733	NN	denotes	limb
T1314	1734-1738	NNS	denotes	buds
T1317	1738-1740	,	denotes	,
T1318	1740-1743	CC	denotes	and
T1319	1744-1746	IN	denotes	in
T1320	1747-1757	JJ	denotes	intrafusal
T1322	1758-1761	NN	denotes	bag
T1321	1762-1768	NNS	denotes	fibers
T1323	1769-1771	IN	denotes	of
T1324	1772-1778	NN	denotes	muscle
T1325	1779-1787	NNS	denotes	spindles
T1326	1788-1793	RB	denotes	later
T1327	1794-1796	IN	denotes	in
T1328	1797-1808	NN	denotes	development
T1329	1809-1810	-LRB-	denotes	(
T1330	1810-1816	NNP	denotes	Copray
T1331	1817-1820	CC	denotes	and
T1332	1821-1828	NNP	denotes	Brouwer
T1333	1829-1833	CD	denotes	1994
T1334	1833-1834	:	denotes	;
T1335	1835-1842	NNP	denotes	Fariñas
T1336	1843-1845	FW	denotes	et
T1337	1846-1849	FW	denotes	al.
T1338	1850-1854	CD	denotes	1996
T1339	1854-1855	:	denotes	;
T1340	1856-1860	NNP	denotes	Tojo
T1341	1861-1863	FW	denotes	et
T1342	1864-1867	FW	denotes	al.
T1343	1868-1872	CD	denotes	1996
T1344	1872-1873	-RRB-	denotes	)
T1345	1873-1874	.	denotes	.
T1346	1874-2018	sentence	denotes	When sensory axons contact developing myotubes, they induce muscle spindle differentiation, forming ring-like spiral nerve endings around them.
T1347	1875-1879	WRB	denotes	When
T1349	1880-1887	JJ	denotes	sensory
T1350	1888-1893	NNS	denotes	axons
T1348	1894-1901	VBP	denotes	contact
T1352	1902-1912	VBG	denotes	developing
T1353	1913-1921	NNS	denotes	myotubes
T1354	1921-1923	,	denotes	,
T1355	1923-1927	PRP	denotes	they
T1351	1928-1934	VBP	denotes	induce
T1356	1935-1941	NN	denotes	muscle
T1357	1942-1949	NN	denotes	spindle
T1358	1950-1965	NN	denotes	differentiation
T1359	1965-1967	,	denotes	,
T1360	1967-1974	VBG	denotes	forming
T1361	1975-1979	NN	denotes	ring
T1363	1979-1980	HYPH	denotes	-
T1362	1980-1984	JJ	denotes	like
T1365	1985-1991	JJ	denotes	spiral
T1366	1992-1997	NN	denotes	nerve
T1364	1998-2005	NNS	denotes	endings
T1367	2006-2012	IN	denotes	around
T1368	2013-2017	PRP	denotes	them
T1369	2017-2018	.	denotes	.
T1370	2018-2220	sentence	denotes	In the chicken embryo, limb ablations or anti-NT-3 antibody injections into limb buds lead to elimination of TrkC-positive neurons and decreased innervation of motor neurons (Oakley et al. 1995, 1997).
T1371	2019-2021	IN	denotes	In
T1373	2022-2025	DT	denotes	the
T1375	2026-2033	NN	denotes	chicken
T1374	2034-2040	NN	denotes	embryo
T1376	2040-2042	,	denotes	,
T1377	2042-2046	NN	denotes	limb
T1378	2047-2056	NNS	denotes	ablations
T1379	2057-2059	CC	denotes	or
T1380	2060-2067	JJ	denotes	anti-NT
T1382	2067-2068	HYPH	denotes	-
T1381	2068-2069	CD	denotes	3
T1383	2070-2078	NN	denotes	antibody
T1384	2079-2089	NNS	denotes	injections
T1385	2090-2094	IN	denotes	into
T1386	2095-2099	NN	denotes	limb
T1387	2100-2104	NNS	denotes	buds
T1372	2105-2109	VBP	denotes	lead
T1388	2110-2112	IN	denotes	to
T1389	2113-2124	NN	denotes	elimination
T1390	2125-2127	IN	denotes	of
T1391	2128-2132	NN	denotes	TrkC
T1393	2132-2133	HYPH	denotes	-
T1392	2133-2141	JJ	denotes	positive
T1394	2142-2149	NNS	denotes	neurons
T1395	2150-2153	CC	denotes	and
T1396	2154-2163	VBN	denotes	decreased
T1397	2164-2175	NN	denotes	innervation
T1398	2176-2178	IN	denotes	of
T1399	2179-2184	NN	denotes	motor
T1400	2185-2192	NNS	denotes	neurons
T1401	2193-2194	-LRB-	denotes	(
T1402	2194-2200	NNP	denotes	Oakley
T1403	2201-2203	FW	denotes	et
T1404	2204-2207	FW	denotes	al.
T1405	2208-2212	CD	denotes	1995
T1406	2212-2214	,	denotes	,
T1407	2214-2218	CD	denotes	1997
T1408	2218-2219	-RRB-	denotes	)
T1409	2219-2220	.	denotes	.
T1410	2220-2422	sentence	denotes	Is NT-3 only a chemotrophic survival factor for muscle sensory afferents, or does it have additional roles in the development of the proprioceptors and the establishment of the monosynaptic reflex arc?
T1411	2221-2223	VBZ	denotes	Is
T1412	2224-2226	NN	denotes	NT
T1413	2226-2227	HYPH	denotes	-
T1414	2227-2228	CD	denotes	3
T1415	2229-2233	RB	denotes	only
T1417	2234-2235	DT	denotes	a
T1418	2236-2248	JJ	denotes	chemotrophic
T1419	2249-2257	NN	denotes	survival
T1416	2258-2264	NN	denotes	factor
T1420	2265-2268	IN	denotes	for
T1421	2269-2275	NN	denotes	muscle
T1423	2276-2283	JJ	denotes	sensory
T1422	2284-2293	NNS	denotes	afferents
T1424	2293-2295	,	denotes	,
T1425	2295-2297	CC	denotes	or
T1426	2298-2302	VBZ	denotes	does
T1428	2303-2305	PRP	denotes	it
T1427	2306-2310	VB	denotes	have
T1429	2311-2321	JJ	denotes	additional
T1430	2322-2327	NNS	denotes	roles
T1431	2328-2330	IN	denotes	in
T1432	2331-2334	DT	denotes	the
T1433	2335-2346	NN	denotes	development
T1434	2347-2349	IN	denotes	of
T1435	2350-2353	DT	denotes	the
T1436	2354-2368	NNS	denotes	proprioceptors
T1437	2369-2372	CC	denotes	and
T1438	2373-2376	DT	denotes	the
T1439	2377-2390	NN	denotes	establishment
T1440	2391-2393	IN	denotes	of
T1441	2394-2397	DT	denotes	the
T1443	2398-2410	JJ	denotes	monosynaptic
T1444	2411-2417	NN	denotes	reflex
T1442	2418-2421	NN	denotes	arc
T1445	2421-2422	.	denotes	?
T1446	2422-2562	sentence	denotes	Here we provide evidence that NT-3 acts as a chemoattractant for sensory axons during the final phase of their target-directed pathfinding.
T1447	2423-2427	RB	denotes	Here
T1449	2428-2430	PRP	denotes	we
T1448	2431-2438	VBP	denotes	provide
T1450	2439-2447	NN	denotes	evidence
T1451	2448-2452	IN	denotes	that
T1453	2453-2455	NN	denotes	NT
T1454	2455-2456	HYPH	denotes	-
T1455	2456-2457	CD	denotes	3
T1452	2458-2462	VBZ	denotes	acts
T1456	2463-2465	IN	denotes	as
T1457	2466-2467	DT	denotes	a
T1458	2468-2483	NN	denotes	chemoattractant
T1459	2484-2487	IN	denotes	for
T1460	2488-2495	JJ	denotes	sensory
T1461	2496-2501	NNS	denotes	axons
T1462	2502-2508	IN	denotes	during
T1463	2509-2512	DT	denotes	the
T1465	2513-2518	JJ	denotes	final
T1464	2519-2524	NN	denotes	phase
T1466	2525-2527	IN	denotes	of
T1467	2528-2533	PRP$	denotes	their
T1469	2534-2540	NN	denotes	target
T1471	2540-2541	HYPH	denotes	-
T1470	2541-2549	VBN	denotes	directed
T1468	2550-2561	NN	denotes	pathfinding
T1472	2561-2562	.	denotes	.
T2324	2573-2577	NN	denotes	TrkC
T2326	2577-2578	HYPH	denotes	-
T2325	2578-2586	JJ	denotes	Positive
T2328	2587-2590	NN	denotes	DRG
T2327	2591-2598	NNS	denotes	Neurons
T2330	2599-2602	VBP	denotes	Are
T2329	2603-2610	VBN	denotes	Rescued
T2331	2611-2613	IN	denotes	in
T2332	2614-2617	NN	denotes	Bax
T2334	2617-2618	HYPH	denotes	/
T2335	2618-2620	NN	denotes	NT
T2336	2620-2621	HYPH	denotes	-
T2337	2621-2622	CD	denotes	3
T2338	2623-2629	JJ	denotes	Double
T2333	2630-2638	NN	denotes	Knockout
T2339	2639-2643	NNS	denotes	Mice
T2340	2643-2760	sentence	denotes	Mice lacking proapoptotic protein Bax allow for distinguishing survival effects of neurotrophins from other effects.
T2341	2644-2648	NNS	denotes	Mice
T2343	2649-2656	VBG	denotes	lacking
T2344	2657-2669	JJ	denotes	proapoptotic
T2346	2670-2677	NN	denotes	protein
T2345	2678-2681	NN	denotes	Bax
T2342	2682-2687	VBP	denotes	allow
T2347	2688-2691	IN	denotes	for
T2348	2692-2706	VBG	denotes	distinguishing
T2349	2707-2715	NN	denotes	survival
T2350	2716-2723	NNS	denotes	effects
T2351	2724-2726	IN	denotes	of
T2352	2727-2740	NNS	denotes	neurotrophins
T2353	2741-2745	IN	denotes	from
T2354	2746-2751	JJ	denotes	other
T2355	2752-2759	NNS	denotes	effects
T2356	2759-2760	.	denotes	.
T2357	2760-2924	sentence	denotes	Bax-deficient sensory neurons no longer require neurotrophins for survival (White et al. 1998; Patel et al. 2000), thus they can be used to examine axonal effects.
T2358	2761-2764	NN	denotes	Bax
T2360	2764-2765	HYPH	denotes	-
T2359	2765-2774	JJ	denotes	deficient
T2362	2775-2782	JJ	denotes	sensory
T2361	2783-2790	NNS	denotes	neurons
T2364	2791-2793	RB	denotes	no
T2365	2794-2800	RB	denotes	longer
T2363	2801-2808	VBP	denotes	require
T2367	2809-2822	NNS	denotes	neurotrophins
T2368	2823-2826	IN	denotes	for
T2369	2827-2835	NN	denotes	survival
T2370	2836-2837	-LRB-	denotes	(
T2371	2837-2842	NNP	denotes	White
T2372	2843-2845	FW	denotes	et
T2373	2846-2849	FW	denotes	al.
T2374	2850-2854	CD	denotes	1998
T2375	2854-2855	:	denotes	;
T2376	2856-2861	NNP	denotes	Patel
T2377	2862-2864	FW	denotes	et
T2378	2865-2868	FW	denotes	al.
T2379	2869-2873	CD	denotes	2000
T2380	2873-2874	-RRB-	denotes	)
T2381	2874-2876	,	denotes	,
T2382	2876-2880	RB	denotes	thus
T2383	2881-2885	PRP	denotes	they
T2384	2886-2889	MD	denotes	can
T2385	2890-2892	VB	denotes	be
T2366	2893-2897	VBN	denotes	used
T2386	2898-2900	TO	denotes	to
T2387	2901-2908	VB	denotes	examine
T2388	2909-2915	JJ	denotes	axonal
T2389	2916-2923	NNS	denotes	effects
T2390	2923-2924	.	denotes	.
T2391	2924-3083	sentence	denotes	We bred NT-3 heterozygote and Bax knockout (KO) mice to obtain mice with double KO of both NT-3 and Bax genes, and examined proprioceptive axonal projections.
T2392	2925-2927	PRP	denotes	We
T2393	2928-2932	VBD	denotes	bred
T2394	2933-2935	NN	denotes	NT
T2396	2935-2936	HYPH	denotes	-
T2397	2936-2937	CD	denotes	3
T2395	2938-2950	NN	denotes	heterozygote
T2398	2951-2954	CC	denotes	and
T2399	2955-2958	NN	denotes	Bax
T2400	2959-2967	NN	denotes	knockout
T2402	2968-2969	-LRB-	denotes	(
T2403	2969-2971	NN	denotes	KO
T2404	2971-2972	-RRB-	denotes	)
T2401	2973-2977	NNS	denotes	mice
T2405	2978-2980	TO	denotes	to
T2406	2981-2987	VB	denotes	obtain
T2407	2988-2992	NNS	denotes	mice
T2408	2993-2997	IN	denotes	with
T2409	2998-3004	JJ	denotes	double
T2410	3005-3007	NN	denotes	KO
T2411	3008-3010	IN	denotes	of
T2412	3011-3015	CC	denotes	both
T2413	3016-3018	NN	denotes	NT
T2415	3018-3019	HYPH	denotes	-
T2416	3019-3020	CD	denotes	3
T2417	3021-3024	CC	denotes	and
T2418	3025-3028	NN	denotes	Bax
T2414	3029-3034	NNS	denotes	genes
T2419	3034-3036	,	denotes	,
T2420	3036-3039	CC	denotes	and
T2421	3040-3048	VBN	denotes	examined
T2422	3049-3063	JJ	denotes	proprioceptive
T2424	3064-3070	JJ	denotes	axonal
T2423	3071-3082	NNS	denotes	projections
T2425	3082-3083	.	denotes	.
T2426	3083-3162	sentence	denotes	All NT-3 and double KOs died within 48 h after birth (Tessarollo et al. 1994).
T2427	3084-3087	DT	denotes	All
T2429	3088-3090	NN	denotes	NT
T2430	3090-3091	HYPH	denotes	-
T2431	3091-3092	CD	denotes	3
T2432	3093-3096	CC	denotes	and
T2433	3097-3103	JJ	denotes	double
T2428	3104-3107	NNS	denotes	KOs
T2434	3108-3112	VBD	denotes	died
T2435	3113-3119	IN	denotes	within
T2436	3120-3122	CD	denotes	48
T2437	3123-3124	NN	denotes	h
T2438	3125-3130	IN	denotes	after
T2439	3131-3136	NN	denotes	birth
T2440	3137-3138	-LRB-	denotes	(
T2441	3138-3148	NNP	denotes	Tessarollo
T2442	3149-3151	FW	denotes	et
T2443	3152-3155	FW	denotes	al.
T2444	3156-3160	CD	denotes	1994
T2445	3160-3161	-RRB-	denotes	)
T2446	3161-3162	.	denotes	.
T2447	3162-3290	sentence	denotes	We performed TrkA/TrkC double immunohistochemistry (Huang et al. 1999), enabling detection of both proteins in the same sample.
T2448	3163-3165	PRP	denotes	We
T2449	3166-3175	VBD	denotes	performed
T2450	3176-3180	NN	denotes	TrkA
T2452	3180-3181	HYPH	denotes	/
T2451	3181-3185	NN	denotes	TrkC
T2454	3186-3192	JJ	denotes	double
T2453	3193-3213	NN	denotes	immunohistochemistry
T2455	3214-3215	-LRB-	denotes	(
T2456	3215-3220	NNP	denotes	Huang
T2457	3221-3223	FW	denotes	et
T2458	3224-3227	FW	denotes	al.
T2459	3228-3232	CD	denotes	1999
T2460	3232-3233	-RRB-	denotes	)
T2461	3233-3235	,	denotes	,
T2462	3235-3243	VBG	denotes	enabling
T2463	3244-3253	NN	denotes	detection
T2464	3254-3256	IN	denotes	of
T2465	3257-3261	DT	denotes	both
T2466	3262-3270	NN	denotes	proteins
T2467	3271-3273	IN	denotes	in
T2468	3274-3277	DT	denotes	the
T2470	3278-3282	JJ	denotes	same
T2469	3283-3289	NN	denotes	sample
T2471	3289-3290	.	denotes	.
T2472	3290-3394	sentence	denotes	TrkC-positive cells (Figure 1A) and fibers (Figure 1E) were absent in NT-3 KOs at embryonic day (E) 15.
T2473	3291-3295	NN	denotes	TrkC
T2475	3295-3296	HYPH	denotes	-
T2474	3296-3304	JJ	denotes	positive
T2476	3305-3310	NNS	denotes	cells
T2478	3311-3312	-LRB-	denotes	(
T2480	3312-3318	NN	denotes	Figure
T2479	3319-3321	NN	denotes	1A
T2481	3321-3322	-RRB-	denotes	)
T2482	3323-3326	CC	denotes	and
T2483	3327-3333	NNS	denotes	fibers
T2484	3334-3335	-LRB-	denotes	(
T2486	3335-3341	NN	denotes	Figure
T2485	3342-3344	NN	denotes	1E
T2487	3344-3345	-RRB-	denotes	)
T2477	3346-3350	VBD	denotes	were
T2488	3351-3357	JJ	denotes	absent
T2489	3358-3360	IN	denotes	in
T2490	3361-3363	NN	denotes	NT
T2492	3363-3364	HYPH	denotes	-
T2493	3364-3365	CD	denotes	3
T2491	3366-3369	NNS	denotes	KOs
T2494	3370-3372	IN	denotes	at
T2495	3373-3382	JJ	denotes	embryonic
T2496	3383-3386	NN	denotes	day
T2497	3387-3388	-LRB-	denotes	(
T2498	3388-3389	NN	denotes	E
T2499	3389-3390	-RRB-	denotes	)
T2500	3391-3393	CD	denotes	15
T2501	3393-3394	.	denotes	.
T2502	3394-3524	sentence	denotes	Two subsets of DRG cells expressing either TrkA or TrkC were detected in double KOs, similar to wild-type (WT) or Bax KO animals.
T2503	3395-3398	CD	denotes	Two
T2504	3399-3406	NNS	denotes	subsets
T2506	3407-3409	IN	denotes	of
T2507	3410-3413	NN	denotes	DRG
T2508	3414-3419	NNS	denotes	cells
T2509	3420-3430	VBG	denotes	expressing
T2510	3431-3437	CC	denotes	either
T2511	3438-3442	NN	denotes	TrkA
T2512	3443-3445	CC	denotes	or
T2513	3446-3450	NN	denotes	TrkC
T2514	3451-3455	VBD	denotes	were
T2505	3456-3464	VBN	denotes	detected
T2515	3465-3467	IN	denotes	in
T2516	3468-3474	JJ	denotes	double
T2517	3475-3478	NNS	denotes	KOs
T2518	3478-3480	,	denotes	,
T2519	3480-3487	JJ	denotes	similar
T2520	3488-3490	IN	denotes	to
T2521	3491-3495	JJ	denotes	wild
T2523	3495-3496	HYPH	denotes	-
T2522	3496-3500	NN	denotes	type
T2525	3501-3502	-LRB-	denotes	(
T2526	3502-3504	NN	denotes	WT
T2527	3504-3505	-RRB-	denotes	)
T2528	3506-3508	CC	denotes	or
T2529	3509-3512	NN	denotes	Bax
T2530	3513-3515	NN	denotes	KO
T2524	3516-3523	NNS	denotes	animals
T2531	3523-3524	.	denotes	.
T2532	3524-3731	sentence	denotes	Surprisingly, at postnatal day (P) 0, a few cells expressed TrkC even in NT-3 KO animals in the Bax +/+ genetic background, and some cells co-expressed TrkA and TrkC, regardless of the genotype (Figure 1B).
T2533	3525-3537	RB	denotes	Surprisingly
T2535	3537-3539	,	denotes	,
T2536	3539-3541	IN	denotes	at
T2537	3542-3551	JJ	denotes	postnatal
T2538	3552-3555	NN	denotes	day
T2539	3556-3557	-LRB-	denotes	(
T2540	3557-3558	NN	denotes	P
T2541	3558-3559	-RRB-	denotes	)
T2542	3560-3561	CD	denotes	0
T2543	3561-3563	,	denotes	,
T2544	3563-3564	DT	denotes	a
T2546	3565-3568	JJ	denotes	few
T2545	3569-3574	NNS	denotes	cells
T2534	3575-3584	VBD	denotes	expressed
T2547	3585-3589	NN	denotes	TrkC
T2548	3590-3594	RB	denotes	even
T2549	3595-3597	IN	denotes	in
T2550	3598-3600	NN	denotes	NT
T2552	3600-3601	HYPH	denotes	-
T2553	3601-3602	CD	denotes	3
T2551	3603-3605	NN	denotes	KO
T2554	3606-3613	NNS	denotes	animals
T2555	3614-3616	IN	denotes	in
T2556	3617-3620	DT	denotes	the
T2558	3621-3624	NN	denotes	Bax
T2559	3625-3626	SYM	denotes	+
T2560	3626-3627	HYPH	denotes	/
T2561	3627-3628	SYM	denotes	+
T2562	3629-3636	JJ	denotes	genetic
T2557	3637-3647	NN	denotes	background
T2563	3647-3649	,	denotes	,
T2564	3649-3652	CC	denotes	and
T2565	3653-3657	DT	denotes	some
T2566	3658-3663	NNS	denotes	cells
T2567	3664-3676	VBD	denotes	co-expressed
T2568	3677-3681	NN	denotes	TrkA
T2569	3682-3685	CC	denotes	and
T2570	3686-3690	NN	denotes	TrkC
T2571	3690-3692	,	denotes	,
T2572	3692-3702	RB	denotes	regardless
T2573	3703-3705	IN	denotes	of
T2574	3706-3709	DT	denotes	the
T2575	3710-3718	NN	denotes	genotype
T2576	3719-3720	-LRB-	denotes	(
T2578	3720-3726	NN	denotes	Figure
T2577	3727-3729	NN	denotes	1B
T2579	3729-3730	-RRB-	denotes	)
T2580	3730-3731	.	denotes	.
T2581	3731-3885	sentence	denotes	In order to quantify our results, we analyzed the ratio of TrkA and TrkC immunopositive cells from four different DRGs of animals of different genotypes.
T2582	3732-3734	IN	denotes	In
T2584	3735-3740	NN	denotes	order
T2585	3741-3743	TO	denotes	to
T2586	3744-3752	VB	denotes	quantify
T2587	3753-3756	PRP$	denotes	our
T2588	3757-3764	NNS	denotes	results
T2589	3764-3766	,	denotes	,
T2590	3766-3768	PRP	denotes	we
T2583	3769-3777	VBD	denotes	analyzed
T2591	3778-3781	DT	denotes	the
T2592	3782-3787	NN	denotes	ratio
T2593	3788-3790	IN	denotes	of
T2594	3791-3795	NN	denotes	TrkA
T2596	3796-3799	CC	denotes	and
T2597	3800-3804	NN	denotes	TrkC
T2595	3805-3819	JJ	denotes	immunopositive
T2598	3820-3825	NNS	denotes	cells
T2599	3826-3830	IN	denotes	from
T2600	3831-3835	CD	denotes	four
T2602	3836-3845	JJ	denotes	different
T2601	3846-3850	NNS	denotes	DRGs
T2603	3851-3853	IN	denotes	of
T2604	3854-3861	NNS	denotes	animals
T2605	3862-3864	IN	denotes	of
T2606	3865-3874	JJ	denotes	different
T2607	3875-3884	NNS	denotes	genotypes
T2608	3884-3885	.	denotes	.
T2609	3885-4041	sentence	denotes	At all ages studied, Bax/NT-3 double null DRGs had TrkA/TrkC ratios similar to those of Bax null DRGs, and higher than those of NT-3 null DRGs (Figure 1D).
T2610	3886-3888	IN	denotes	At
T2612	3889-3892	DT	denotes	all
T2613	3893-3897	NNS	denotes	ages
T2614	3898-3905	VBN	denotes	studied
T2615	3905-3907	,	denotes	,
T2616	3907-3910	NN	denotes	Bax
T2618	3910-3911	HYPH	denotes	/
T2619	3911-3913	NN	denotes	NT
T2620	3913-3914	HYPH	denotes	-
T2621	3914-3915	CD	denotes	3
T2622	3916-3922	JJ	denotes	double
T2617	3923-3927	JJ	denotes	null
T2623	3928-3932	NNS	denotes	DRGs
T2611	3933-3936	VBD	denotes	had
T2624	3937-3941	NN	denotes	TrkA
T2626	3941-3942	HYPH	denotes	/
T2625	3942-3946	NN	denotes	TrkC
T2627	3947-3953	NNS	denotes	ratios
T2628	3954-3961	JJ	denotes	similar
T2629	3962-3964	IN	denotes	to
T2630	3965-3970	DT	denotes	those
T2631	3971-3973	IN	denotes	of
T2632	3974-3977	NN	denotes	Bax
T2633	3978-3982	JJ	denotes	null
T2634	3983-3987	NNS	denotes	DRGs
T2635	3987-3989	,	denotes	,
T2636	3989-3992	CC	denotes	and
T2637	3993-3999	JJR	denotes	higher
T2638	4000-4004	IN	denotes	than
T2639	4005-4010	DT	denotes	those
T2640	4011-4013	IN	denotes	of
T2641	4014-4016	NN	denotes	NT
T2643	4016-4017	HYPH	denotes	-
T2644	4017-4018	CD	denotes	3
T2642	4019-4023	JJ	denotes	null
T2645	4024-4028	NNS	denotes	DRGs
T2646	4029-4030	-LRB-	denotes	(
T2648	4030-4036	NN	denotes	Figure
T2647	4037-4039	NN	denotes	1D
T2649	4039-4040	-RRB-	denotes	)
T2650	4040-4041	.	denotes	.
T2651	4041-4239	sentence	denotes	TrkC-positive neurons rescued by Bax deletion, however, failed to differentiate properly, as evidenced by the lack of expression of the proprioceptive molecular marker Parvalbumin (PV) (Figure 1C).
T2652	4042-4046	NN	denotes	TrkC
T2654	4046-4047	HYPH	denotes	-
T2653	4047-4055	JJ	denotes	positive
T2655	4056-4063	NNS	denotes	neurons
T2657	4064-4071	VBN	denotes	rescued
T2658	4072-4074	IN	denotes	by
T2659	4075-4078	NN	denotes	Bax
T2660	4079-4087	NN	denotes	deletion
T2661	4087-4089	,	denotes	,
T2662	4089-4096	RB	denotes	however
T2663	4096-4098	,	denotes	,
T2656	4098-4104	VBD	denotes	failed
T2664	4105-4107	TO	denotes	to
T2665	4108-4121	VB	denotes	differentiate
T2666	4122-4130	RB	denotes	properly
T2667	4130-4132	,	denotes	,
T2668	4132-4134	IN	denotes	as
T2669	4135-4144	VBN	denotes	evidenced
T2670	4145-4147	IN	denotes	by
T2671	4148-4151	DT	denotes	the
T2672	4152-4156	NN	denotes	lack
T2673	4157-4159	IN	denotes	of
T2674	4160-4170	NN	denotes	expression
T2675	4171-4173	IN	denotes	of
T2676	4174-4177	DT	denotes	the
T2678	4178-4192	JJ	denotes	proprioceptive
T2679	4193-4202	JJ	denotes	molecular
T2677	4203-4209	NN	denotes	marker
T2680	4210-4221	NN	denotes	Parvalbumin
T2681	4222-4223	-LRB-	denotes	(
T2682	4223-4225	NN	denotes	PV
T2683	4225-4226	-RRB-	denotes	)
T2684	4227-4228	-LRB-	denotes	(
T2686	4228-4234	NN	denotes	Figure
T2685	4235-4237	NN	denotes	1C
T2687	4237-4238	-RRB-	denotes	)
T2688	4238-4239	.	denotes	.
T3969	5055-5057	NN	denotes	NT
T3971	5057-5058	HYPH	denotes	-
T3972	5058-5059	CD	denotes	3
T3970	5060-5062	VBZ	denotes	Is
T3973	5063-5072	JJ	denotes	Necessary
T3974	5073-5076	IN	denotes	for
T3975	5077-5083	JJ	denotes	Proper
T3976	5084-5095	NN	denotes	Innervation
T3977	5096-5098	IN	denotes	of
T3978	5099-5104	JJ	denotes	Motor
T3979	5105-5112	NNS	denotes	Neurons
T3980	5112-5195	sentence	denotes	TrkA/TrkC-positive fibers in the spinal cord could be detected at E15 (Figure 1E).
T3981	5113-5117	NN	denotes	TrkA
T3983	5117-5118	HYPH	denotes	/
T3982	5118-5122	NN	denotes	TrkC
T3985	5122-5123	HYPH	denotes	-
T3984	5123-5131	JJ	denotes	positive
T3986	5132-5138	NNS	denotes	fibers
T3988	5139-5141	IN	denotes	in
T3989	5142-5145	DT	denotes	the
T3991	5146-5152	JJ	denotes	spinal
T3990	5153-5157	NN	denotes	cord
T3992	5158-5163	MD	denotes	could
T3993	5164-5166	VB	denotes	be
T3987	5167-5175	VBN	denotes	detected
T3994	5176-5178	IN	denotes	at
T3995	5179-5182	NN	denotes	E15
T3996	5183-5184	-LRB-	denotes	(
T3998	5184-5190	NN	denotes	Figure
T3997	5191-5193	NN	denotes	1E
T3999	5193-5194	-RRB-	denotes	)
T4000	5194-5195	.	denotes	.
T4001	5195-5431	sentence	denotes	TrkA-positive fibers were restricted to and terminated in the dorsolateral spinal cord, whereas TrkC-positive fibers entered the cord dorsomedially, and descended into the ventral horns in WT (Ozaki and Snider 1997) and Bax KO embryos.
T4002	5196-5200	NN	denotes	TrkA
T4004	5200-5201	HYPH	denotes	-
T4003	5201-5209	JJ	denotes	positive
T4005	5210-5216	NNS	denotes	fibers
T4007	5217-5221	VBD	denotes	were
T4006	5222-5232	VBN	denotes	restricted
T4008	5233-5235	IN	denotes	to
T4009	5236-5239	CC	denotes	and
T4010	5240-5250	VBN	denotes	terminated
T4011	5251-5253	IN	denotes	in
T4012	5254-5257	DT	denotes	the
T4014	5258-5270	JJ	denotes	dorsolateral
T4015	5271-5277	JJ	denotes	spinal
T4013	5278-5282	NN	denotes	cord
T4016	5282-5284	,	denotes	,
T4017	5284-5291	IN	denotes	whereas
T4019	5292-5296	NN	denotes	TrkC
T4021	5296-5297	HYPH	denotes	-
T4020	5297-5305	JJ	denotes	positive
T4022	5306-5312	NNS	denotes	fibers
T4018	5313-5320	VBD	denotes	entered
T4023	5321-5324	DT	denotes	the
T4024	5325-5329	NN	denotes	cord
T4025	5330-5343	RB	denotes	dorsomedially
T4026	5343-5345	,	denotes	,
T4027	5345-5348	CC	denotes	and
T4028	5349-5358	VBD	denotes	descended
T4029	5359-5363	IN	denotes	into
T4030	5364-5367	DT	denotes	the
T4032	5368-5375	JJ	denotes	ventral
T4031	5376-5381	NNS	denotes	horns
T4033	5382-5384	IN	denotes	in
T4034	5385-5387	NN	denotes	WT
T4036	5388-5389	-LRB-	denotes	(
T4037	5389-5394	NNP	denotes	Ozaki
T4038	5395-5398	CC	denotes	and
T4039	5399-5405	NNP	denotes	Snider
T4040	5406-5410	CD	denotes	1997
T4041	5410-5411	-RRB-	denotes	)
T4042	5412-5415	CC	denotes	and
T4043	5416-5419	NN	denotes	Bax
T4044	5420-5422	NN	denotes	KO
T4035	5423-5430	NNS	denotes	embryos
T4045	5430-5431	.	denotes	.
T4046	5431-5549	sentence	denotes	There was no detectable TrkC expression in NT-3 KO spinal cord, indicating complete absence of proprioceptive fibers.
T4047	5432-5437	EX	denotes	There
T4048	5438-5441	VBD	denotes	was
T4049	5442-5444	DT	denotes	no
T4051	5445-5455	JJ	denotes	detectable
T4052	5456-5460	NN	denotes	TrkC
T4050	5461-5471	NN	denotes	expression
T4053	5472-5474	IN	denotes	in
T4054	5475-5477	NN	denotes	NT
T4056	5477-5478	HYPH	denotes	-
T4057	5478-5479	CD	denotes	3
T4055	5480-5482	NN	denotes	KO
T4059	5483-5489	JJ	denotes	spinal
T4058	5490-5494	NN	denotes	cord
T4060	5494-5496	,	denotes	,
T4061	5496-5506	VBG	denotes	indicating
T4062	5507-5515	JJ	denotes	complete
T4063	5516-5523	NN	denotes	absence
T4064	5524-5526	IN	denotes	of
T4065	5527-5541	JJ	denotes	proprioceptive
T4066	5542-5548	NNS	denotes	fibers
T4067	5548-5549	.	denotes	.
T4068	5549-5706	sentence	denotes	In double KO spinal cord, TrkC-positive fibers entered the dorsal spinal cord and descended medially in a manner similar to that seen in WT or Bax KO cases.
T4069	5550-5552	IN	denotes	In
T4071	5553-5559	JJ	denotes	double
T4072	5560-5562	NN	denotes	KO
T4074	5563-5569	JJ	denotes	spinal
T4073	5570-5574	NN	denotes	cord
T4075	5574-5576	,	denotes	,
T4076	5576-5580	NN	denotes	TrkC
T4078	5580-5581	HYPH	denotes	-
T4077	5581-5589	JJ	denotes	positive
T4079	5590-5596	NNS	denotes	fibers
T4070	5597-5604	VBD	denotes	entered
T4080	5605-5608	DT	denotes	the
T4082	5609-5615	JJ	denotes	dorsal
T4083	5616-5622	JJ	denotes	spinal
T4081	5623-5627	NN	denotes	cord
T4084	5628-5631	CC	denotes	and
T4085	5632-5641	VBN	denotes	descended
T4086	5642-5650	RB	denotes	medially
T4087	5651-5653	IN	denotes	in
T4088	5654-5655	DT	denotes	a
T4089	5656-5662	NN	denotes	manner
T4090	5663-5670	JJ	denotes	similar
T4091	5671-5673	IN	denotes	to
T4092	5674-5678	DT	denotes	that
T4093	5679-5683	VBN	denotes	seen
T4094	5684-5686	IN	denotes	in
T4095	5687-5689	NN	denotes	WT
T4097	5690-5692	CC	denotes	or
T4098	5693-5696	NN	denotes	Bax
T4099	5697-5699	NN	denotes	KO
T4096	5700-5705	NNS	denotes	cases
T4100	5705-5706	.	denotes	.
T4101	5706-5828	sentence	denotes	However, it was not possible to follow TrkC immunolabeled fibers all the way to their terminal zones in any of the cases.
T4102	5707-5714	RB	denotes	However
T4104	5714-5716	,	denotes	,
T4105	5716-5718	PRP	denotes	it
T4103	5719-5722	VBD	denotes	was
T4106	5723-5726	RB	denotes	not
T4107	5727-5735	JJ	denotes	possible
T4108	5736-5738	TO	denotes	to
T4109	5739-5745	VB	denotes	follow
T4110	5746-5750	NN	denotes	TrkC
T4112	5751-5764	VBN	denotes	immunolabeled
T4111	5765-5771	NNS	denotes	fibers
T4113	5772-5775	PDT	denotes	all
T4115	5776-5779	DT	denotes	the
T4114	5780-5783	NN	denotes	way
T4116	5784-5786	IN	denotes	to
T4117	5787-5792	PRP$	denotes	their
T4119	5793-5801	JJ	denotes	terminal
T4118	5802-5807	NNS	denotes	zones
T4120	5808-5810	IN	denotes	in
T4121	5811-5814	DT	denotes	any
T4122	5815-5817	IN	denotes	of
T4123	5818-5821	DT	denotes	the
T4124	5822-5827	NNS	denotes	cases
T4125	5827-5828	.	denotes	.
T4126	5828-5920	sentence	denotes	Next we examined the central projections of DRG axons with the lipophilic tracer DiI at P0.
T4127	5829-5833	RB	denotes	Next
T4129	5834-5836	PRP	denotes	we
T4128	5837-5845	VBD	denotes	examined
T4130	5846-5849	DT	denotes	the
T4132	5850-5857	JJ	denotes	central
T4131	5858-5869	NNS	denotes	projections
T4133	5870-5872	IN	denotes	of
T4134	5873-5876	NN	denotes	DRG
T4135	5877-5882	NNS	denotes	axons
T4136	5883-5887	IN	denotes	with
T4137	5888-5891	DT	denotes	the
T4139	5892-5902	JJ	denotes	lipophilic
T4138	5903-5909	NN	denotes	tracer
T4140	5910-5913	NN	denotes	DiI
T4141	5914-5916	IN	denotes	at
T4142	5917-5919	NN	denotes	P0
T4143	5919-5920	.	denotes	.
T4144	5920-6054	sentence	denotes	In WT and Bax KO pups, proprioceptive afferents entered the dorsal spinal cord and followed a medial course towards the ventral horn.
T4145	5921-5923	IN	denotes	In
T4147	5924-5926	NN	denotes	WT
T4149	5927-5930	CC	denotes	and
T4150	5931-5934	NN	denotes	Bax
T4151	5935-5937	NN	denotes	KO
T4148	5938-5942	NNS	denotes	pups
T4152	5942-5944	,	denotes	,
T4153	5944-5958	JJ	denotes	proprioceptive
T4154	5959-5968	NNS	denotes	afferents
T4146	5969-5976	VBD	denotes	entered
T4155	5977-5980	DT	denotes	the
T4157	5981-5987	JJ	denotes	dorsal
T4158	5988-5994	JJ	denotes	spinal
T4156	5995-5999	NN	denotes	cord
T4159	6000-6003	CC	denotes	and
T4160	6004-6012	VBD	denotes	followed
T4161	6013-6014	DT	denotes	a
T4163	6015-6021	JJ	denotes	medial
T4162	6022-6028	NN	denotes	course
T4164	6029-6036	IN	denotes	towards
T4165	6037-6040	DT	denotes	the
T4167	6041-6048	JJ	denotes	ventral
T4166	6049-6053	NN	denotes	horn
T4168	6053-6054	.	denotes	.
T4169	6054-6180	sentence	denotes	They then turned laterally towards motor neurons in the lateral motor column, where they branched and terminated (Figure 2A).
T4170	6055-6059	PRP	denotes	They
T4172	6060-6064	RB	denotes	then
T4171	6065-6071	VBD	denotes	turned
T4173	6072-6081	RB	denotes	laterally
T4174	6082-6089	IN	denotes	towards
T4175	6090-6095	NN	denotes	motor
T4176	6096-6103	NNS	denotes	neurons
T4177	6104-6106	IN	denotes	in
T4178	6107-6110	DT	denotes	the
T4180	6111-6118	JJ	denotes	lateral
T4181	6119-6124	NN	denotes	motor
T4179	6125-6131	NN	denotes	column
T4182	6131-6133	,	denotes	,
T4183	6133-6138	WRB	denotes	where
T4185	6139-6143	PRP	denotes	they
T4184	6144-6152	VBD	denotes	branched
T4186	6153-6156	CC	denotes	and
T4187	6157-6167	VBD	denotes	terminated
T4188	6168-6169	-LRB-	denotes	(
T4190	6169-6175	NN	denotes	Figure
T4189	6176-6178	NN	denotes	2A
T4191	6178-6179	-RRB-	denotes	)
T4192	6179-6180	.	denotes	.
T4193	6180-6386	sentence	denotes	DiI labeling was confined to dorsal spinal cord in NT-3 KOs (Figure 2A), as reported earlier, consistent with a complete absence of proprioceptive innervation (Ernfors et al. 1994; Tessarollo et al. 1994).
T4194	6181-6184	NN	denotes	DiI
T4195	6185-6193	NN	denotes	labeling
T4197	6194-6197	VBD	denotes	was
T4196	6198-6206	VBN	denotes	confined
T4198	6207-6209	IN	denotes	to
T4199	6210-6216	JJ	denotes	dorsal
T4201	6217-6223	JJ	denotes	spinal
T4200	6224-6228	NN	denotes	cord
T4202	6229-6231	IN	denotes	in
T4203	6232-6234	NN	denotes	NT
T4205	6234-6235	HYPH	denotes	-
T4206	6235-6236	CD	denotes	3
T4204	6237-6240	NNS	denotes	KOs
T4207	6241-6242	-LRB-	denotes	(
T4209	6242-6248	NN	denotes	Figure
T4208	6249-6251	NN	denotes	2A
T4210	6251-6252	-RRB-	denotes	)
T4211	6252-6254	,	denotes	,
T4212	6254-6256	IN	denotes	as
T4213	6257-6265	VBN	denotes	reported
T4214	6266-6273	RB	denotes	earlier
T4215	6273-6275	,	denotes	,
T4216	6275-6285	JJ	denotes	consistent
T4217	6286-6290	IN	denotes	with
T4218	6291-6292	DT	denotes	a
T4220	6293-6301	JJ	denotes	complete
T4219	6302-6309	NN	denotes	absence
T4221	6310-6312	IN	denotes	of
T4222	6313-6327	JJ	denotes	proprioceptive
T4223	6328-6339	NN	denotes	innervation
T4224	6340-6341	-LRB-	denotes	(
T4225	6341-6348	NNP	denotes	Ernfors
T4226	6349-6351	FW	denotes	et
T4227	6352-6355	FW	denotes	al.
T4228	6356-6360	CD	denotes	1994
T4229	6360-6361	:	denotes	;
T4230	6362-6372	NNP	denotes	Tessarollo
T4231	6373-6375	FW	denotes	et
T4232	6376-6379	FW	denotes	al.
T4233	6380-6384	CD	denotes	1994
T4234	6384-6385	-RRB-	denotes	)
T4235	6385-6386	.	denotes	.
T4236	6386-6596	sentence	denotes	In double KOs, proprioceptive afferents initially followed a trajectory similar to that of WT counterparts, but most of them failed to project all the way to the ventral cord and into the lateral motor column.
T4237	6387-6389	IN	denotes	In
T4239	6390-6396	JJ	denotes	double
T4240	6397-6400	NNS	denotes	KOs
T4241	6400-6402	,	denotes	,
T4242	6402-6416	JJ	denotes	proprioceptive
T4243	6417-6426	NNS	denotes	afferents
T4244	6427-6436	RB	denotes	initially
T4238	6437-6445	VBD	denotes	followed
T4245	6446-6447	DT	denotes	a
T4246	6448-6458	NN	denotes	trajectory
T4247	6459-6466	JJ	denotes	similar
T4248	6467-6469	IN	denotes	to
T4249	6470-6474	DT	denotes	that
T4250	6475-6477	IN	denotes	of
T4251	6478-6480	NN	denotes	WT
T4252	6481-6493	NNS	denotes	counterparts
T4253	6493-6495	,	denotes	,
T4254	6495-6498	CC	denotes	but
T4255	6499-6503	JJS	denotes	most
T4257	6504-6506	IN	denotes	of
T4258	6507-6511	PRP	denotes	them
T4256	6512-6518	VBD	denotes	failed
T4259	6519-6521	TO	denotes	to
T4260	6522-6529	VB	denotes	project
T4261	6530-6533	PDT	denotes	all
T4263	6534-6537	DT	denotes	the
T4262	6538-6541	NN	denotes	way
T4264	6542-6544	IN	denotes	to
T4265	6545-6548	DT	denotes	the
T4267	6549-6556	JJ	denotes	ventral
T4266	6557-6561	NN	denotes	cord
T4268	6562-6565	CC	denotes	and
T4269	6566-6570	IN	denotes	into
T4270	6571-6574	DT	denotes	the
T4272	6575-6582	JJ	denotes	lateral
T4273	6583-6588	NN	denotes	motor
T4271	6589-6595	NN	denotes	column
T4274	6595-6596	.	denotes	.
T4275	6596-6740	sentence	denotes	Instead, they arborized near the ventral midline; some crossed the midline and extended into the contralateral ventral cord (Figure 2A and 2C).
T4276	6597-6604	RB	denotes	Instead
T4278	6604-6606	,	denotes	,
T4279	6606-6610	PRP	denotes	they
T4277	6611-6620	VBD	denotes	arborized
T4281	6621-6625	IN	denotes	near
T4282	6626-6629	DT	denotes	the
T4284	6630-6637	JJ	denotes	ventral
T4283	6638-6645	NN	denotes	midline
T4285	6645-6646	:	denotes	;
T4286	6647-6651	DT	denotes	some
T4280	6652-6659	VBD	denotes	crossed
T4287	6660-6663	DT	denotes	the
T4288	6664-6671	NN	denotes	midline
T4289	6672-6675	CC	denotes	and
T4290	6676-6684	VBD	denotes	extended
T4291	6685-6689	IN	denotes	into
T4292	6690-6693	DT	denotes	the
T4294	6694-6707	JJ	denotes	contralateral
T4295	6708-6715	JJ	denotes	ventral
T4293	6716-6720	NN	denotes	cord
T4296	6721-6722	-LRB-	denotes	(
T4298	6722-6728	NN	denotes	Figure
T4297	6729-6731	NN	denotes	2A
T4299	6732-6735	CC	denotes	and
T4300	6736-6738	NN	denotes	2C
T4301	6738-6739	-RRB-	denotes	)
T4302	6739-6740	.	denotes	.
T4303	6740-6895	sentence	denotes	In order to distinguish between a role for NT-3 in initiation of motor neuron innervation and a role for maintenance, we repeated the DiI labeling at E17.
T4304	6741-6743	IN	denotes	In
T4306	6744-6749	NN	denotes	order
T4307	6750-6752	TO	denotes	to
T4308	6753-6764	VB	denotes	distinguish
T4309	6765-6772	IN	denotes	between
T4310	6773-6774	DT	denotes	a
T4311	6775-6779	NN	denotes	role
T4312	6780-6783	IN	denotes	for
T4313	6784-6786	NN	denotes	NT
T4314	6786-6787	HYPH	denotes	-
T4315	6787-6788	CD	denotes	3
T4316	6789-6791	IN	denotes	in
T4317	6792-6802	NN	denotes	initiation
T4318	6803-6805	IN	denotes	of
T4319	6806-6811	NN	denotes	motor
T4320	6812-6818	NN	denotes	neuron
T4321	6819-6830	NN	denotes	innervation
T4322	6831-6834	CC	denotes	and
T4323	6835-6836	DT	denotes	a
T4324	6837-6841	NN	denotes	role
T4325	6842-6845	IN	denotes	for
T4326	6846-6857	NN	denotes	maintenance
T4327	6857-6859	,	denotes	,
T4328	6859-6861	PRP	denotes	we
T4305	6862-6870	VBD	denotes	repeated
T4329	6871-6874	DT	denotes	the
T4331	6875-6878	NN	denotes	DiI
T4330	6879-6887	NN	denotes	labeling
T4332	6888-6890	IN	denotes	at
T4333	6891-6894	NN	denotes	E17
T4334	6894-6895	.	denotes	.
T4335	6895-6987	sentence	denotes	Innervation patterns of E17 spinal cords (Figure 3) were similar to those at P0 (Figure 2).
T4336	6896-6907	NN	denotes	Innervation
T4337	6908-6916	NNS	denotes	patterns
T4339	6917-6919	IN	denotes	of
T4340	6920-6923	NN	denotes	E17
T4342	6924-6930	JJ	denotes	spinal
T4341	6931-6936	NNS	denotes	cords
T4343	6937-6938	-LRB-	denotes	(
T4344	6938-6944	NN	denotes	Figure
T4345	6945-6946	CD	denotes	3
T4346	6946-6947	-RRB-	denotes	)
T4338	6948-6952	VBD	denotes	were
T4347	6953-6960	JJ	denotes	similar
T4348	6961-6963	IN	denotes	to
T4349	6964-6969	DT	denotes	those
T4350	6970-6972	IN	denotes	at
T4351	6973-6975	NN	denotes	P0
T4352	6976-6977	-LRB-	denotes	(
T4353	6977-6983	NN	denotes	Figure
T4354	6984-6985	CD	denotes	2
T4355	6985-6986	-RRB-	denotes	)
T4356	6986-6987	.	denotes	.
T4357	6987-7119	sentence	denotes	Dorsal horns of all genotypes were filled with DiI-labeled fibers corresponding to nerve growth factor–dependent nociceptive axons.
T4358	6988-6994	JJ	denotes	Dorsal
T4359	6995-7000	NNS	denotes	horns
T4361	7001-7003	IN	denotes	of
T4362	7004-7007	DT	denotes	all
T4363	7008-7017	NNS	denotes	genotypes
T4364	7018-7022	VBD	denotes	were
T4360	7023-7029	VBN	denotes	filled
T4365	7030-7034	IN	denotes	with
T4366	7035-7038	NN	denotes	DiI
T4368	7038-7039	HYPH	denotes	-
T4367	7039-7046	VBN	denotes	labeled
T4369	7047-7053	NNS	denotes	fibers
T4370	7054-7067	VBG	denotes	corresponding
T4371	7068-7070	IN	denotes	to
T4372	7071-7076	NN	denotes	nerve
T4374	7077-7083	NN	denotes	growth
T4373	7084-7090	NN	denotes	factor
T4376	7090-7091	HYPH	denotes	–
T4375	7091-7100	JJ	denotes	dependent
T4378	7101-7112	JJ	denotes	nociceptive
T4377	7113-7118	NNS	denotes	axons
T4379	7118-7119	.	denotes	.
T4380	7119-7320	sentence	denotes	In WT and Bax KO embryos, proprioceptive fibers extended towards ventral horn motor neurons (Figure 3A and 3B), whereas the ventral horns of the NT-3 KO embryos were devoid of innervation (Figure 3C).
T4381	7120-7122	IN	denotes	In
T4383	7123-7125	NN	denotes	WT
T4385	7126-7129	CC	denotes	and
T4386	7130-7133	NN	denotes	Bax
T4387	7134-7136	NN	denotes	KO
T4384	7137-7144	NNS	denotes	embryos
T4388	7144-7146	,	denotes	,
T4389	7146-7160	JJ	denotes	proprioceptive
T4390	7161-7167	NNS	denotes	fibers
T4382	7168-7176	VBN	denotes	extended
T4391	7177-7184	IN	denotes	towards
T4392	7185-7192	JJ	denotes	ventral
T4393	7193-7197	NN	denotes	horn
T4395	7198-7203	NN	denotes	motor
T4394	7204-7211	NNS	denotes	neurons
T4396	7212-7213	-LRB-	denotes	(
T4398	7213-7219	NN	denotes	Figure
T4397	7220-7222	NN	denotes	3A
T4399	7223-7226	CC	denotes	and
T4400	7227-7229	NN	denotes	3B
T4401	7229-7230	-RRB-	denotes	)
T4402	7230-7232	,	denotes	,
T4403	7232-7239	IN	denotes	whereas
T4405	7240-7243	DT	denotes	the
T4407	7244-7251	JJ	denotes	ventral
T4406	7252-7257	NNS	denotes	horns
T4408	7258-7260	IN	denotes	of
T4409	7261-7264	DT	denotes	the
T4411	7265-7267	NN	denotes	NT
T4413	7267-7268	HYPH	denotes	-
T4414	7268-7269	CD	denotes	3
T4412	7270-7272	NN	denotes	KO
T4410	7273-7280	NNS	denotes	embryos
T4404	7281-7285	VBD	denotes	were
T4415	7286-7292	JJ	denotes	devoid
T4416	7293-7295	IN	denotes	of
T4417	7296-7307	NN	denotes	innervation
T4418	7308-7309	-LRB-	denotes	(
T4420	7309-7315	NN	denotes	Figure
T4419	7316-7318	NN	denotes	3C
T4421	7318-7319	-RRB-	denotes	)
T4422	7319-7320	.	denotes	.
T4423	7320-7519	sentence	denotes	In the Bax/NT-3 double KOs, DiI-labeled fibers entered the ventral spinal cord, but extended towards the midline instead of the ventral horn (Figure 3D), in a pattern similar to that observed at P0.
T4424	7321-7323	IN	denotes	In
T4426	7324-7327	DT	denotes	the
T4428	7328-7331	NN	denotes	Bax
T4429	7331-7332	HYPH	denotes	/
T4430	7332-7334	NN	denotes	NT
T4431	7334-7335	HYPH	denotes	-
T4432	7335-7336	CD	denotes	3
T4433	7337-7343	JJ	denotes	double
T4427	7344-7347	NNS	denotes	KOs
T4434	7347-7349	,	denotes	,
T4435	7349-7352	NN	denotes	DiI
T4437	7352-7353	HYPH	denotes	-
T4436	7353-7360	VBN	denotes	labeled
T4438	7361-7367	NNS	denotes	fibers
T4425	7368-7375	VBD	denotes	entered
T4439	7376-7379	DT	denotes	the
T4441	7380-7387	JJ	denotes	ventral
T4442	7388-7394	JJ	denotes	spinal
T4440	7395-7399	NN	denotes	cord
T4443	7399-7401	,	denotes	,
T4444	7401-7404	CC	denotes	but
T4445	7405-7413	VBD	denotes	extended
T4446	7414-7421	IN	denotes	towards
T4447	7422-7425	DT	denotes	the
T4448	7426-7433	NN	denotes	midline
T4449	7434-7441	RB	denotes	instead
T4450	7442-7444	IN	denotes	of
T4451	7445-7448	DT	denotes	the
T4453	7449-7456	JJ	denotes	ventral
T4452	7457-7461	NN	denotes	horn
T4454	7462-7463	-LRB-	denotes	(
T4456	7463-7469	NN	denotes	Figure
T4455	7470-7472	NN	denotes	3D
T4457	7472-7473	-RRB-	denotes	)
T4458	7473-7475	,	denotes	,
T4459	7475-7477	IN	denotes	in
T4460	7478-7479	DT	denotes	a
T4461	7480-7487	NN	denotes	pattern
T4462	7488-7495	JJ	denotes	similar
T4463	7496-7498	IN	denotes	to
T4464	7499-7503	DT	denotes	that
T4465	7504-7512	VBN	denotes	observed
T4466	7513-7515	IN	denotes	at
T4467	7516-7518	NN	denotes	P0
T4468	7518-7519	.	denotes	.
T4469	7519-7689	sentence	denotes	Our data point to a complete absence of proprioceptive innervation of the ventral horn of the Bax/NT-3 null spinal cord throughout the developmental stages investigated.
T4470	7520-7523	PRP$	denotes	Our
T4471	7524-7528	NNS	denotes	data
T4472	7529-7534	VBP	denotes	point
T4473	7535-7537	IN	denotes	to
T4474	7538-7539	DT	denotes	a
T4476	7540-7548	JJ	denotes	complete
T4475	7549-7556	NN	denotes	absence
T4477	7557-7559	IN	denotes	of
T4478	7560-7574	JJ	denotes	proprioceptive
T4479	7575-7586	NN	denotes	innervation
T4480	7587-7589	IN	denotes	of
T4481	7590-7593	DT	denotes	the
T4483	7594-7601	JJ	denotes	ventral
T4482	7602-7606	NN	denotes	horn
T4484	7607-7609	IN	denotes	of
T4485	7610-7613	DT	denotes	the
T4487	7614-7617	NN	denotes	Bax
T4489	7617-7618	HYPH	denotes	/
T4490	7618-7620	NN	denotes	NT
T4491	7620-7621	HYPH	denotes	-
T4492	7621-7622	CD	denotes	3
T4488	7623-7627	JJ	denotes	null
T4493	7628-7634	JJ	denotes	spinal
T4486	7635-7639	NN	denotes	cord
T4494	7640-7650	IN	denotes	throughout
T4495	7651-7654	DT	denotes	the
T4497	7655-7668	JJ	denotes	developmental
T4496	7669-7675	NNS	denotes	stages
T4498	7676-7688	VBN	denotes	investigated
T4499	7688-7689	.	denotes	.
T4500	7689-7829	sentence	denotes	As the sensory axons never reach motor neuron dendrites in the ventral horn (Figure S1), the stretch reflex arc circuit is not established.
T4501	7690-7692	IN	denotes	As
T4503	7693-7696	DT	denotes	the
T4505	7697-7704	JJ	denotes	sensory
T4504	7705-7710	NNS	denotes	axons
T4506	7711-7716	RB	denotes	never
T4502	7717-7722	VBP	denotes	reach
T4508	7723-7728	NN	denotes	motor
T4509	7729-7735	NN	denotes	neuron
T4510	7736-7745	NNS	denotes	dendrites
T4511	7746-7748	IN	denotes	in
T4512	7749-7752	DT	denotes	the
T4514	7753-7760	JJ	denotes	ventral
T4513	7761-7765	NN	denotes	horn
T4515	7766-7767	-LRB-	denotes	(
T4517	7767-7773	NN	denotes	Figure
T4516	7774-7776	NN	denotes	S1
T4518	7776-7777	-RRB-	denotes	)
T4519	7777-7779	,	denotes	,
T4520	7779-7782	DT	denotes	the
T4522	7783-7790	NN	denotes	stretch
T4523	7791-7797	NN	denotes	reflex
T4524	7798-7801	NN	denotes	arc
T4521	7802-7809	NN	denotes	circuit
T4525	7810-7812	VBZ	denotes	is
T4526	7813-7816	RB	denotes	not
T4507	7817-7828	VBN	denotes	established
T4527	7828-7829	.	denotes	.
T4528	7829-8033	sentence	denotes	The failure to initiate contact between sensory axons and motor neurons in the absence of NT-3 suggests a requirement for NT-3 for proper axon targeting in addition to a role in sensory axon maintenance.
T4529	7830-7833	DT	denotes	The
T4530	7834-7841	NN	denotes	failure
T4532	7842-7844	TO	denotes	to
T4533	7845-7853	VB	denotes	initiate
T4534	7854-7861	NN	denotes	contact
T4535	7862-7869	IN	denotes	between
T4536	7870-7877	JJ	denotes	sensory
T4537	7878-7883	NNS	denotes	axons
T4538	7884-7887	CC	denotes	and
T4539	7888-7893	NN	denotes	motor
T4540	7894-7901	NNS	denotes	neurons
T4541	7902-7904	IN	denotes	in
T4542	7905-7908	DT	denotes	the
T4543	7909-7916	NN	denotes	absence
T4544	7917-7919	IN	denotes	of
T4545	7920-7922	NN	denotes	NT
T4546	7922-7923	HYPH	denotes	-
T4547	7923-7924	CD	denotes	3
T4531	7925-7933	VBZ	denotes	suggests
T4548	7934-7935	DT	denotes	a
T4549	7936-7947	NN	denotes	requirement
T4550	7948-7951	IN	denotes	for
T4551	7952-7954	NN	denotes	NT
T4552	7954-7955	HYPH	denotes	-
T4553	7955-7956	CD	denotes	3
T4554	7957-7960	IN	denotes	for
T4555	7961-7967	JJ	denotes	proper
T4556	7968-7972	NN	denotes	axon
T4557	7973-7982	VBG	denotes	targeting
T4558	7983-7985	IN	denotes	in
T4559	7986-7994	NN	denotes	addition
T4560	7995-7997	IN	denotes	to
T4561	7998-7999	DT	denotes	a
T4562	8000-8004	NN	denotes	role
T4563	8005-8007	IN	denotes	in
T4564	8008-8015	JJ	denotes	sensory
T4565	8016-8020	NN	denotes	axon
T4566	8021-8032	NN	denotes	maintenance
T4567	8032-8033	.	denotes	.
T5932	9306-9308	NN	denotes	NT
T5934	9308-9309	HYPH	denotes	-
T5935	9309-9310	CD	denotes	3
T5936	9311-9313	VBZ	denotes	Is
T5933	9314-9322	VBN	denotes	Required
T5937	9323-9326	IN	denotes	for
T5938	9327-9333	JJ	denotes	Proper
T5940	9334-9344	JJ	denotes	Peripheral
T5939	9345-9356	NN	denotes	Innervation
T5941	9356-9484	sentence	denotes	In order to study peripheral innervation in double KO animals, we investigated spindle development in the gastrocnemius muscle.
T5942	9357-9359	IN	denotes	In
T5944	9360-9365	NN	denotes	order
T5945	9366-9368	TO	denotes	to
T5946	9369-9374	VB	denotes	study
T5947	9375-9385	JJ	denotes	peripheral
T5948	9386-9397	NN	denotes	innervation
T5949	9398-9400	IN	denotes	in
T5950	9401-9407	JJ	denotes	double
T5951	9408-9410	NN	denotes	KO
T5952	9411-9418	NNS	denotes	animals
T5953	9418-9420	,	denotes	,
T5954	9420-9422	PRP	denotes	we
T5943	9423-9435	VBD	denotes	investigated
T5955	9436-9443	NN	denotes	spindle
T5956	9444-9455	NN	denotes	development
T5957	9456-9458	IN	denotes	in
T5958	9459-9462	DT	denotes	the
T5960	9463-9476	NN	denotes	gastrocnemius
T5959	9477-9483	NN	denotes	muscle
T5961	9483-9484	.	denotes	.
T5962	9484-9610	sentence	denotes	Muscle spindles could be identified easily in P0 WT and Bax KO animals by their characteristic morphology (Figure 4A and 4B).
T5963	9485-9491	NN	denotes	Muscle
T5964	9492-9500	NNS	denotes	spindles
T5966	9501-9506	MD	denotes	could
T5967	9507-9509	VB	denotes	be
T5965	9510-9520	VBN	denotes	identified
T5968	9521-9527	RB	denotes	easily
T5969	9528-9530	IN	denotes	in
T5970	9531-9533	NN	denotes	P0
T5972	9534-9536	NN	denotes	WT
T5973	9537-9540	CC	denotes	and
T5974	9541-9544	NN	denotes	Bax
T5975	9545-9547	NN	denotes	KO
T5971	9548-9555	NNS	denotes	animals
T5976	9556-9558	IN	denotes	by
T5977	9559-9564	PRP$	denotes	their
T5979	9565-9579	JJ	denotes	characteristic
T5978	9580-9590	NN	denotes	morphology
T5980	9591-9592	-LRB-	denotes	(
T5982	9592-9598	NN	denotes	Figure
T5981	9599-9601	NN	denotes	4A
T5983	9602-9605	CC	denotes	and
T5984	9606-9608	NN	denotes	4B
T5985	9608-9609	-RRB-	denotes	)
T5986	9609-9610	.	denotes	.
T5987	9610-9854	sentence	denotes	Proprioceptive fibers labeled with neurofilament-M (NF-M) antibody formed ring-like spiral endings wrapped around intrafusal bag fibers labeled with S46 antibody, specific for slow developmental myosin heavy chain protein (Miller et al. 1985).
T5988	9611-9625	JJ	denotes	Proprioceptive
T5989	9626-9632	NNS	denotes	fibers
T5991	9633-9640	VBN	denotes	labeled
T5992	9641-9645	IN	denotes	with
T5993	9646-9659	NN	denotes	neurofilament
T5995	9659-9660	HYPH	denotes	-
T5994	9660-9661	NN	denotes	M
T5997	9662-9663	-LRB-	denotes	(
T5998	9663-9665	NN	denotes	NF
T6000	9665-9666	HYPH	denotes	-
T5999	9666-9667	NN	denotes	M
T6001	9667-9668	-RRB-	denotes	)
T5996	9669-9677	NN	denotes	antibody
T5990	9678-9684	VBD	denotes	formed
T6002	9685-9689	NN	denotes	ring
T6004	9689-9690	HYPH	denotes	-
T6003	9690-9694	JJ	denotes	like
T6006	9695-9701	JJ	denotes	spiral
T6005	9702-9709	NNS	denotes	endings
T6007	9710-9717	VBN	denotes	wrapped
T6008	9718-9724	IN	denotes	around
T6009	9725-9735	JJ	denotes	intrafusal
T6011	9736-9739	NN	denotes	bag
T6010	9740-9746	NNS	denotes	fibers
T6012	9747-9754	VBN	denotes	labeled
T6013	9755-9759	IN	denotes	with
T6014	9760-9763	NN	denotes	S46
T6015	9764-9772	NN	denotes	antibody
T6016	9772-9774	,	denotes	,
T6017	9774-9782	JJ	denotes	specific
T6018	9783-9786	IN	denotes	for
T6019	9787-9791	JJ	denotes	slow
T6020	9792-9805	JJ	denotes	developmental
T6022	9806-9812	NN	denotes	myosin
T6023	9813-9818	JJ	denotes	heavy
T6024	9819-9824	NN	denotes	chain
T6021	9825-9832	NN	denotes	protein
T6025	9833-9834	-LRB-	denotes	(
T6026	9834-9840	NNP	denotes	Miller
T6027	9841-9843	FW	denotes	et
T6028	9844-9847	FW	denotes	al.
T6029	9848-9852	CD	denotes	1985
T6030	9852-9853	-RRB-	denotes	)
T6031	9853-9854	.	denotes	.
T6032	9854-9947	sentence	denotes	As reported earlier, there were no muscle spindles in NT-3 KO animals (Ernfors et al. 1994).
T6033	9855-9857	IN	denotes	As
T6034	9858-9866	VBN	denotes	reported
T6036	9867-9874	RBR	denotes	earlier
T6037	9874-9876	,	denotes	,
T6038	9876-9881	EX	denotes	there
T6035	9882-9886	VBD	denotes	were
T6039	9887-9889	DT	denotes	no
T6041	9890-9896	NN	denotes	muscle
T6040	9897-9905	NNS	denotes	spindles
T6042	9906-9908	IN	denotes	in
T6043	9909-9911	NN	denotes	NT
T6045	9911-9912	HYPH	denotes	-
T6046	9912-9913	CD	denotes	3
T6044	9914-9916	NN	denotes	KO
T6047	9917-9924	NNS	denotes	animals
T6048	9925-9926	-LRB-	denotes	(
T6049	9926-9933	NNP	denotes	Ernfors
T6050	9934-9936	FW	denotes	et
T6051	9937-9940	FW	denotes	al.
T6052	9941-9945	CD	denotes	1994
T6053	9945-9946	-RRB-	denotes	)
T6054	9946-9947	.	denotes	.
T6055	9947-10114	sentence	denotes	On the other hand, Bax KO animals had more spindles than WT, and spindles were in clusters similar to animals over-expressing NT-3 in the muscle (Wright et al. 1997).
T6056	9948-9950	IN	denotes	On
T6058	9951-9954	DT	denotes	the
T6060	9955-9960	JJ	denotes	other
T6059	9961-9965	NN	denotes	hand
T6061	9965-9967	,	denotes	,
T6062	9967-9970	NN	denotes	Bax
T6063	9971-9973	NN	denotes	KO
T6064	9974-9981	NNS	denotes	animals
T6057	9982-9985	VBD	denotes	had
T6065	9986-9990	JJR	denotes	more
T6066	9991-9999	NNS	denotes	spindles
T6067	10000-10004	IN	denotes	than
T6068	10005-10007	NN	denotes	WT
T6069	10007-10009	,	denotes	,
T6070	10009-10012	CC	denotes	and
T6071	10013-10021	NNS	denotes	spindles
T6072	10022-10026	VBD	denotes	were
T6073	10027-10029	IN	denotes	in
T6074	10030-10038	NNS	denotes	clusters
T6075	10039-10046	JJ	denotes	similar
T6076	10047-10049	IN	denotes	to
T6077	10050-10057	NNS	denotes	animals
T6078	10058-10073	VBG	denotes	over-expressing
T6079	10074-10076	NN	denotes	NT
T6080	10076-10077	HYPH	denotes	-
T6081	10077-10078	CD	denotes	3
T6082	10079-10081	IN	denotes	in
T6083	10082-10085	DT	denotes	the
T6084	10086-10092	NN	denotes	muscle
T6085	10093-10094	-LRB-	denotes	(
T6086	10094-10100	NNP	denotes	Wright
T6087	10101-10103	FW	denotes	et
T6088	10104-10107	FW	denotes	al.
T6089	10108-10112	CD	denotes	1997
T6090	10112-10113	-RRB-	denotes	)
T6091	10113-10114	.	denotes	.
T6092	10114-10238	sentence	denotes	Although NT-3-dependent cells were rescued, no muscle spindles were detected in the limbs of double KOs (Figure 4A and 4B).
T6093	10115-10123	IN	denotes	Although
T6095	10124-10126	NN	denotes	NT
T6097	10126-10127	HYPH	denotes	-
T6098	10127-10128	CD	denotes	3
T6099	10128-10129	HYPH	denotes	-
T6096	10129-10138	JJ	denotes	dependent
T6100	10139-10144	NNS	denotes	cells
T6101	10145-10149	VBD	denotes	were
T6094	10150-10157	VBN	denotes	rescued
T6103	10157-10159	,	denotes	,
T6104	10159-10161	DT	denotes	no
T6106	10162-10168	NN	denotes	muscle
T6105	10169-10177	NNS	denotes	spindles
T6107	10178-10182	VBD	denotes	were
T6102	10183-10191	VBN	denotes	detected
T6108	10192-10194	IN	denotes	in
T6109	10195-10198	DT	denotes	the
T6110	10199-10204	NNS	denotes	limbs
T6111	10205-10207	IN	denotes	of
T6112	10208-10214	JJ	denotes	double
T6113	10215-10218	NNS	denotes	KOs
T6114	10219-10220	-LRB-	denotes	(
T6116	10220-10226	NN	denotes	Figure
T6115	10227-10229	NN	denotes	4A
T6117	10230-10233	CC	denotes	and
T6118	10234-10236	NN	denotes	4B
T6119	10236-10237	-RRB-	denotes	)
T6120	10237-10238	.	denotes	.
T6121	10238-10360	sentence	denotes	Muscle spindles could be observed with TrkC antibody in WT and Bax KO animals, but not in NT-3 or double KOs (Figure 4E).
T6122	10239-10245	NN	denotes	Muscle
T6123	10246-10254	NNS	denotes	spindles
T6125	10255-10260	MD	denotes	could
T6126	10261-10263	VB	denotes	be
T6124	10264-10272	VBN	denotes	observed
T6127	10273-10277	IN	denotes	with
T6128	10278-10282	NN	denotes	TrkC
T6129	10283-10291	NN	denotes	antibody
T6130	10292-10294	IN	denotes	in
T6131	10295-10297	NN	denotes	WT
T6133	10298-10301	CC	denotes	and
T6134	10302-10305	NN	denotes	Bax
T6135	10306-10308	NN	denotes	KO
T6132	10309-10316	NNS	denotes	animals
T6136	10316-10318	,	denotes	,
T6137	10318-10321	CC	denotes	but
T6138	10322-10325	RB	denotes	not
T6139	10326-10328	IN	denotes	in
T6140	10329-10331	NN	denotes	NT
T6142	10331-10332	HYPH	denotes	-
T6143	10332-10333	CD	denotes	3
T6144	10334-10336	CC	denotes	or
T6145	10337-10343	JJ	denotes	double
T6141	10344-10347	NNS	denotes	KOs
T6146	10348-10349	-LRB-	denotes	(
T6148	10349-10355	NN	denotes	Figure
T6147	10356-10358	NN	denotes	4E
T6149	10358-10359	-RRB-	denotes	)
T6150	10359-10360	.	denotes	.
T6151	10360-10524	sentence	denotes	In both NT-3 and double KO animals, NF-M-labeled fibers could be detected in muscles, thus the muscles of these animals were not completely devoid of nerve fibers.
T6152	10361-10363	IN	denotes	In
T6154	10364-10368	CC	denotes	both
T6155	10369-10371	NN	denotes	NT
T6157	10371-10372	HYPH	denotes	-
T6158	10372-10373	CD	denotes	3
T6159	10374-10377	CC	denotes	and
T6160	10378-10384	JJ	denotes	double
T6156	10385-10387	NN	denotes	KO
T6161	10388-10395	NNS	denotes	animals
T6162	10395-10397	,	denotes	,
T6163	10397-10399	NN	denotes	NF
T6165	10399-10400	HYPH	denotes	-
T6164	10400-10401	NN	denotes	M
T6167	10401-10402	HYPH	denotes	-
T6166	10402-10409	VBN	denotes	labeled
T6168	10410-10416	NNS	denotes	fibers
T6169	10417-10422	MD	denotes	could
T6170	10423-10425	VB	denotes	be
T6153	10426-10434	VBN	denotes	detected
T6172	10435-10437	IN	denotes	in
T6173	10438-10445	NNS	denotes	muscles
T6174	10445-10447	,	denotes	,
T6175	10447-10451	RB	denotes	thus
T6176	10452-10455	DT	denotes	the
T6177	10456-10463	NNS	denotes	muscles
T6178	10464-10466	IN	denotes	of
T6179	10467-10472	DT	denotes	these
T6180	10473-10480	NNS	denotes	animals
T6171	10481-10485	VBD	denotes	were
T6181	10486-10489	RB	denotes	not
T6182	10490-10500	RB	denotes	completely
T6183	10501-10507	JJ	denotes	devoid
T6184	10508-10510	IN	denotes	of
T6185	10511-10516	NN	denotes	nerve
T6186	10517-10523	NNS	denotes	fibers
T6187	10523-10524	.	denotes	.
T6188	10524-10650	sentence	denotes	Since there were no TrkC-positive fibers in these muscles, we think that these NF-M-labeled fibers correspond to motor axons.
T6189	10525-10530	IN	denotes	Since
T6191	10531-10536	EX	denotes	there
T6190	10537-10541	VBD	denotes	were
T6193	10542-10544	DT	denotes	no
T6195	10545-10549	NN	denotes	TrkC
T6196	10549-10550	HYPH	denotes	-
T6197	10550-10558	JJ	denotes	positive
T6194	10559-10565	NNS	denotes	fibers
T6198	10566-10568	IN	denotes	in
T6199	10569-10574	DT	denotes	these
T6200	10575-10582	NNS	denotes	muscles
T6201	10582-10584	,	denotes	,
T6202	10584-10586	PRP	denotes	we
T6192	10587-10592	VBP	denotes	think
T6203	10593-10597	IN	denotes	that
T6205	10598-10603	DT	denotes	these
T6207	10604-10606	NN	denotes	NF
T6209	10606-10607	HYPH	denotes	-
T6208	10607-10608	NN	denotes	M
T6211	10608-10609	HYPH	denotes	-
T6210	10609-10616	VBN	denotes	labeled
T6206	10617-10623	NNS	denotes	fibers
T6204	10624-10634	VBP	denotes	correspond
T6212	10635-10637	IN	denotes	to
T6213	10638-10643	NN	denotes	motor
T6214	10644-10649	NNS	denotes	axons
T6215	10649-10650	.	denotes	.
T6216	10650-10828	sentence	denotes	Absence of muscle spindles might be due to a failure in initiation of differentiation by proprioceptive axons, or a failure of maturation and maintenance in the absence of NT-3.
T6217	10651-10658	NN	denotes	Absence
T6219	10659-10661	IN	denotes	of
T6220	10662-10668	NN	denotes	muscle
T6221	10669-10677	NNS	denotes	spindles
T6222	10678-10683	MD	denotes	might
T6218	10684-10686	VB	denotes	be
T6223	10687-10690	IN	denotes	due
T6224	10691-10693	IN	denotes	to
T6225	10694-10695	DT	denotes	a
T6226	10696-10703	NN	denotes	failure
T6227	10704-10706	IN	denotes	in
T6228	10707-10717	NN	denotes	initiation
T6229	10718-10720	IN	denotes	of
T6230	10721-10736	NN	denotes	differentiation
T6231	10737-10739	IN	denotes	by
T6232	10740-10754	JJ	denotes	proprioceptive
T6233	10755-10760	NNS	denotes	axons
T6234	10760-10762	,	denotes	,
T6235	10762-10764	CC	denotes	or
T6236	10765-10766	DT	denotes	a
T6237	10767-10774	NN	denotes	failure
T6238	10775-10777	IN	denotes	of
T6239	10778-10788	NN	denotes	maturation
T6240	10789-10792	CC	denotes	and
T6241	10793-10804	NN	denotes	maintenance
T6242	10805-10807	IN	denotes	in
T6243	10808-10811	DT	denotes	the
T6244	10812-10819	NN	denotes	absence
T6245	10820-10822	IN	denotes	of
T6246	10823-10825	NN	denotes	NT
T6247	10825-10826	HYPH	denotes	-
T6248	10826-10827	CD	denotes	3
T6249	10827-10828	.	denotes	.
T6250	10828-10988	sentence	denotes	To distinguish between these two possibilities, we investigated muscle spindle development at E15 and E17 with S46/NF-M immunostaining as well as DiI labeling.
T6251	10829-10831	TO	denotes	To
T6252	10832-10843	VB	denotes	distinguish
T6254	10844-10851	IN	denotes	between
T6255	10852-10857	DT	denotes	these
T6257	10858-10861	CD	denotes	two
T6256	10862-10875	NNS	denotes	possibilities
T6258	10875-10877	,	denotes	,
T6259	10877-10879	PRP	denotes	we
T6253	10880-10892	VBD	denotes	investigated
T6260	10893-10899	NN	denotes	muscle
T6261	10900-10907	NN	denotes	spindle
T6262	10908-10919	NN	denotes	development
T6263	10920-10922	IN	denotes	at
T6264	10923-10926	NN	denotes	E15
T6265	10927-10930	CC	denotes	and
T6266	10931-10934	NN	denotes	E17
T6267	10935-10939	IN	denotes	with
T6268	10940-10943	NN	denotes	S46
T6270	10943-10944	HYPH	denotes	/
T6271	10944-10946	NN	denotes	NF
T6273	10946-10947	HYPH	denotes	-
T6272	10947-10948	NN	denotes	M
T6269	10949-10963	NN	denotes	immunostaining
T6274	10964-10966	RB	denotes	as
T6276	10967-10971	RB	denotes	well
T6275	10972-10974	IN	denotes	as
T6277	10975-10978	NN	denotes	DiI
T6278	10979-10987	NN	denotes	labeling
T6279	10987-10988	.	denotes	.
T6280	10988-11109	sentence	denotes	No structures with the characteristic muscle spindle shape could be detected in any of the genotypes at E15 (Figure S2).
T6281	10989-10991	DT	denotes	No
T6282	10992-11002	NNS	denotes	structures
T6284	11003-11007	IN	denotes	with
T6285	11008-11011	DT	denotes	the
T6287	11012-11026	JJ	denotes	characteristic
T6288	11027-11033	NN	denotes	muscle
T6289	11034-11041	NN	denotes	spindle
T6286	11042-11047	NN	denotes	shape
T6290	11048-11053	MD	denotes	could
T6291	11054-11056	VB	denotes	be
T6283	11057-11065	VBN	denotes	detected
T6292	11066-11068	IN	denotes	in
T6293	11069-11072	DT	denotes	any
T6294	11073-11075	IN	denotes	of
T6295	11076-11079	DT	denotes	the
T6296	11080-11089	NNS	denotes	genotypes
T6297	11090-11092	IN	denotes	at
T6298	11093-11096	NN	denotes	E15
T6299	11097-11098	-LRB-	denotes	(
T6301	11098-11104	NN	denotes	Figure
T6300	11105-11107	NN	denotes	S2
T6302	11107-11108	-RRB-	denotes	)
T6303	11108-11109	.	denotes	.
T6304	11109-11233	sentence	denotes	However, numerous developing spindles could be identified at E17 in WT and Bax KOs, but not in NT-3 KO embryos (Figure 4C).
T6305	11110-11117	RB	denotes	However
T6307	11117-11119	,	denotes	,
T6308	11119-11127	JJ	denotes	numerous
T6310	11128-11138	VBG	denotes	developing
T6309	11139-11147	NNS	denotes	spindles
T6311	11148-11153	MD	denotes	could
T6312	11154-11156	VB	denotes	be
T6306	11157-11167	VBN	denotes	identified
T6313	11168-11170	IN	denotes	at
T6314	11171-11174	NN	denotes	E17
T6315	11175-11177	IN	denotes	in
T6316	11178-11180	NN	denotes	WT
T6317	11181-11184	CC	denotes	and
T6318	11185-11188	NN	denotes	Bax
T6319	11189-11192	NNS	denotes	KOs
T6320	11192-11194	,	denotes	,
T6321	11194-11197	CC	denotes	but
T6322	11198-11201	RB	denotes	not
T6323	11202-11204	IN	denotes	in
T6324	11205-11207	NN	denotes	NT
T6326	11207-11208	HYPH	denotes	-
T6327	11208-11209	CD	denotes	3
T6325	11210-11212	NN	denotes	KO
T6328	11213-11220	NNS	denotes	embryos
T6329	11221-11222	-LRB-	denotes	(
T6331	11222-11228	NN	denotes	Figure
T6330	11229-11231	NN	denotes	4C
T6332	11231-11232	-RRB-	denotes	)
T6333	11232-11233	.	denotes	.
T6334	11233-11415	sentence	denotes	Bax/NT-3 double null muscles were devoid of spindles (Figure 4C), except for one spindle-like structure observed in one leg of an embryo (Figure 4C, inset, denoted by the asterisk).
T6335	11234-11237	NN	denotes	Bax
T6337	11237-11238	HYPH	denotes	/
T6338	11238-11240	NN	denotes	NT
T6339	11240-11241	HYPH	denotes	-
T6340	11241-11242	CD	denotes	3
T6341	11243-11249	JJ	denotes	double
T6336	11250-11254	JJ	denotes	null
T6342	11255-11262	NNS	denotes	muscles
T6343	11263-11267	VBD	denotes	were
T6344	11268-11274	JJ	denotes	devoid
T6345	11275-11277	IN	denotes	of
T6346	11278-11286	NNS	denotes	spindles
T6347	11287-11288	-LRB-	denotes	(
T6349	11288-11294	NN	denotes	Figure
T6348	11295-11297	NN	denotes	4C
T6350	11297-11298	-RRB-	denotes	)
T6351	11298-11300	,	denotes	,
T6352	11300-11306	IN	denotes	except
T6353	11307-11310	IN	denotes	for
T6354	11311-11314	CD	denotes	one
T6356	11315-11322	NN	denotes	spindle
T6358	11322-11323	HYPH	denotes	-
T6357	11323-11327	JJ	denotes	like
T6355	11328-11337	NN	denotes	structure
T6359	11338-11346	VBN	denotes	observed
T6360	11347-11349	IN	denotes	in
T6361	11350-11353	CD	denotes	one
T6362	11354-11357	NN	denotes	leg
T6363	11358-11360	IN	denotes	of
T6364	11361-11363	DT	denotes	an
T6365	11364-11370	NN	denotes	embryo
T6366	11371-11372	-LRB-	denotes	(
T6368	11372-11378	NN	denotes	Figure
T6369	11379-11381	NN	denotes	4C
T6370	11381-11383	,	denotes	,
T6371	11383-11388	NN	denotes	inset
T6372	11388-11390	,	denotes	,
T6367	11390-11397	VBN	denotes	denoted
T6373	11398-11400	IN	denotes	by
T6374	11401-11404	DT	denotes	the
T6375	11405-11413	NN	denotes	asterisk
T6376	11413-11414	-RRB-	denotes	)
T6377	11414-11415	.	denotes	.
T6378	11415-11608	sentence	denotes	DiI labeling through the DRGs at E17 yielded similar results, with muscle spindles identified in parallel sections in WT and Bax null muscles (Figure 4D), but not in NT-3 or double KO animals.
T6379	11416-11419	NN	denotes	DiI
T6380	11420-11428	NN	denotes	labeling
T6382	11429-11436	IN	denotes	through
T6383	11437-11440	DT	denotes	the
T6384	11441-11445	NNS	denotes	DRGs
T6385	11446-11448	IN	denotes	at
T6386	11449-11452	NN	denotes	E17
T6381	11453-11460	VBD	denotes	yielded
T6387	11461-11468	JJ	denotes	similar
T6388	11469-11476	NNS	denotes	results
T6389	11476-11478	,	denotes	,
T6390	11478-11482	IN	denotes	with
T6392	11483-11489	NN	denotes	muscle
T6393	11490-11498	NNS	denotes	spindles
T6391	11499-11509	VBN	denotes	identified
T6394	11510-11512	IN	denotes	in
T6395	11513-11521	JJ	denotes	parallel
T6396	11522-11530	NNS	denotes	sections
T6397	11531-11533	IN	denotes	in
T6398	11534-11536	NN	denotes	WT
T6400	11537-11540	CC	denotes	and
T6401	11541-11544	NN	denotes	Bax
T6402	11545-11549	JJ	denotes	null
T6399	11550-11557	NNS	denotes	muscles
T6403	11558-11559	-LRB-	denotes	(
T6405	11559-11565	NN	denotes	Figure
T6404	11566-11568	NN	denotes	4D
T6406	11568-11569	-RRB-	denotes	)
T6407	11569-11571	,	denotes	,
T6408	11571-11574	CC	denotes	but
T6409	11575-11578	RB	denotes	not
T6410	11579-11581	IN	denotes	in
T6411	11582-11584	NN	denotes	NT
T6413	11584-11585	HYPH	denotes	-
T6414	11585-11586	CD	denotes	3
T6415	11587-11589	CC	denotes	or
T6416	11590-11596	JJ	denotes	double
T6412	11597-11599	NN	denotes	KO
T6417	11600-11607	NNS	denotes	animals
T6418	11607-11608	.	denotes	.
T6419	11608-11752	sentence	denotes	Although DiI-labeled fibers could be detected in double null muscles, they never formed ring-like structures characteristic of muscle spindles.
T6420	11609-11617	IN	denotes	Although
T6422	11618-11621	NN	denotes	DiI
T6424	11621-11622	HYPH	denotes	-
T6423	11622-11629	VBN	denotes	labeled
T6425	11630-11636	NNS	denotes	fibers
T6426	11637-11642	MD	denotes	could
T6427	11643-11645	VB	denotes	be
T6421	11646-11654	VBN	denotes	detected
T6429	11655-11657	IN	denotes	in
T6430	11658-11664	JJ	denotes	double
T6431	11665-11669	JJ	denotes	null
T6432	11670-11677	NNS	denotes	muscles
T6433	11677-11679	,	denotes	,
T6434	11679-11683	PRP	denotes	they
T6435	11684-11689	RB	denotes	never
T6428	11690-11696	VBD	denotes	formed
T6436	11697-11701	NN	denotes	ring
T6438	11701-11702	HYPH	denotes	-
T6437	11702-11706	JJ	denotes	like
T6439	11707-11717	NNS	denotes	structures
T6440	11718-11732	JJ	denotes	characteristic
T6441	11733-11735	IN	denotes	of
T6442	11736-11742	NN	denotes	muscle
T6443	11743-11751	NNS	denotes	spindles
T6444	11751-11752	.	denotes	.
T6445	11752-11912	sentence	denotes	We also examined TrkA/TrkC expression at P0 in the tibial nerve, which carries sensory fibers to the gastrocnemius muscle as well as the skin of the lower leg.
T6446	11753-11755	PRP	denotes	We
T6448	11756-11760	RB	denotes	also
T6447	11761-11769	VBD	denotes	examined
T6449	11770-11774	NN	denotes	TrkA
T6451	11774-11775	HYPH	denotes	/
T6450	11775-11779	NN	denotes	TrkC
T6452	11780-11790	NN	denotes	expression
T6453	11791-11793	IN	denotes	at
T6454	11794-11796	NN	denotes	P0
T6455	11797-11799	IN	denotes	in
T6456	11800-11803	DT	denotes	the
T6458	11804-11810	JJ	denotes	tibial
T6457	11811-11816	NN	denotes	nerve
T6459	11816-11818	,	denotes	,
T6460	11818-11823	WDT	denotes	which
T6461	11824-11831	VBZ	denotes	carries
T6462	11832-11839	JJ	denotes	sensory
T6463	11840-11846	NNS	denotes	fibers
T6464	11847-11849	IN	denotes	to
T6465	11850-11853	DT	denotes	the
T6467	11854-11867	NN	denotes	gastrocnemius
T6466	11868-11874	NN	denotes	muscle
T6468	11875-11877	RB	denotes	as
T6470	11878-11882	RB	denotes	well
T6469	11883-11885	IN	denotes	as
T6471	11886-11889	DT	denotes	the
T6472	11890-11894	NN	denotes	skin
T6473	11895-11897	IN	denotes	of
T6474	11898-11901	DT	denotes	the
T6476	11902-11907	JJR	denotes	lower
T6475	11908-11911	NN	denotes	leg
T6477	11911-11912	.	denotes	.
T6478	11912-12127	sentence	denotes	In NT-3 KOs, TrkA-positive axons could be seen in the tibial nerve but there were no TrkC-positive axons; in contrast, TrkA- and TrkC-labeled axons are both present in WT, Bax KO, and double KO animals (Figure 4F).
T6479	11913-11915	IN	denotes	In
T6481	11916-11918	NN	denotes	NT
T6483	11918-11919	HYPH	denotes	-
T6484	11919-11920	CD	denotes	3
T6482	11921-11924	NNS	denotes	KOs
T6485	11924-11926	,	denotes	,
T6486	11926-11930	NN	denotes	TrkA
T6488	11930-11931	HYPH	denotes	-
T6487	11931-11939	JJ	denotes	positive
T6489	11940-11945	NNS	denotes	axons
T6490	11946-11951	MD	denotes	could
T6491	11952-11954	VB	denotes	be
T6480	11955-11959	VBN	denotes	seen
T6493	11960-11962	IN	denotes	in
T6494	11963-11966	DT	denotes	the
T6496	11967-11973	JJ	denotes	tibial
T6495	11974-11979	NN	denotes	nerve
T6497	11980-11983	CC	denotes	but
T6498	11984-11989	EX	denotes	there
T6499	11990-11994	VBD	denotes	were
T6500	11995-11997	DT	denotes	no
T6502	11998-12002	NN	denotes	TrkC
T6504	12002-12003	HYPH	denotes	-
T6503	12003-12011	JJ	denotes	positive
T6501	12012-12017	NNS	denotes	axons
T6505	12017-12018	:	denotes	;
T6506	12019-12021	IN	denotes	in
T6507	12022-12030	NN	denotes	contrast
T6508	12030-12032	,	denotes	,
T6509	12032-12036	NN	denotes	TrkA
T6511	12036-12037	HYPH	denotes	-
T6512	12038-12041	CC	denotes	and
T6513	12042-12046	NN	denotes	TrkC
T6514	12046-12047	HYPH	denotes	-
T6510	12047-12054	VBN	denotes	labeled
T6515	12055-12060	NNS	denotes	axons
T6492	12061-12064	VBP	denotes	are
T6516	12065-12069	RB	denotes	both
T6517	12070-12077	JJ	denotes	present
T6518	12078-12080	IN	denotes	in
T6519	12081-12083	NN	denotes	WT
T6521	12083-12085	,	denotes	,
T6522	12085-12088	NN	denotes	Bax
T6523	12089-12091	NN	denotes	KO
T6524	12091-12093	,	denotes	,
T6525	12093-12096	CC	denotes	and
T6526	12097-12103	JJ	denotes	double
T6527	12104-12106	NN	denotes	KO
T6520	12107-12114	NNS	denotes	animals
T6528	12115-12116	-LRB-	denotes	(
T6530	12116-12122	NN	denotes	Figure
T6529	12123-12125	NN	denotes	4F
T6531	12125-12126	-RRB-	denotes	)
T6532	12126-12127	.	denotes	.
T6533	12127-12308	sentence	denotes	These results suggest that although proprioceptive axons follow proper trajectories in distal peripheral nerves, they fail to innervate their target muscles in the absence of NT-3.
T6534	12128-12133	DT	denotes	These
T6535	12134-12141	NNS	denotes	results
T6536	12142-12149	VBP	denotes	suggest
T6537	12150-12154	IN	denotes	that
T6539	12155-12163	IN	denotes	although
T6541	12164-12178	JJ	denotes	proprioceptive
T6542	12179-12184	NNS	denotes	axons
T6540	12185-12191	VBP	denotes	follow
T6543	12192-12198	JJ	denotes	proper
T6544	12199-12211	NNS	denotes	trajectories
T6545	12212-12214	IN	denotes	in
T6546	12215-12221	JJ	denotes	distal
T6548	12222-12232	JJ	denotes	peripheral
T6547	12233-12239	NNS	denotes	nerves
T6549	12239-12241	,	denotes	,
T6550	12241-12245	PRP	denotes	they
T6538	12246-12250	VBP	denotes	fail
T6551	12251-12253	TO	denotes	to
T6552	12254-12263	VB	denotes	innervate
T6553	12264-12269	PRP$	denotes	their
T6555	12270-12276	NN	denotes	target
T6554	12277-12284	NNS	denotes	muscles
T6556	12285-12287	IN	denotes	in
T6557	12288-12291	DT	denotes	the
T6558	12292-12299	NN	denotes	absence
T6559	12300-12302	IN	denotes	of
T6560	12303-12305	NN	denotes	NT
T6561	12305-12306	HYPH	denotes	-
T6562	12306-12307	CD	denotes	3
T6563	12307-12308	.	denotes	.
T7869	13565-13567	NN	denotes	NT
T7871	13567-13568	HYPH	denotes	-
T7872	13568-13569	CD	denotes	3
T7870	13570-13572	VBZ	denotes	Is
T7873	13573-13574	DT	denotes	a
T7874	13575-13590	NN	denotes	Chemoattractant
T7875	13591-13594	IN	denotes	for
T7876	13595-13598	NN	denotes	DRG
T7877	13599-13604	NNS	denotes	Axons
T7878	13605-13607	FW	denotes	In
T7879	13608-13613	FW	denotes	Vitro
T7880	13613-13733	sentence	denotes	To test the hypothesis that NT-3 acts as a chemoattractant for sensory axons, we performed a series of in vitro assays.
T7881	13614-13616	TO	denotes	To
T7882	13617-13621	VB	denotes	test
T7884	13622-13625	DT	denotes	the
T7885	13626-13636	NN	denotes	hypothesis
T7886	13637-13641	IN	denotes	that
T7888	13642-13644	NN	denotes	NT
T7889	13644-13645	HYPH	denotes	-
T7890	13645-13646	CD	denotes	3
T7887	13647-13651	VBZ	denotes	acts
T7891	13652-13654	IN	denotes	as
T7892	13655-13656	DT	denotes	a
T7893	13657-13672	NN	denotes	chemoattractant
T7894	13673-13676	IN	denotes	for
T7895	13677-13684	JJ	denotes	sensory
T7896	13685-13690	NNS	denotes	axons
T7897	13690-13692	,	denotes	,
T7898	13692-13694	PRP	denotes	we
T7883	13695-13704	VBD	denotes	performed
T7899	13705-13706	DT	denotes	a
T7900	13707-13713	NN	denotes	series
T7901	13714-13716	IN	denotes	of
T7902	13717-13719	FW	denotes	in
T7903	13720-13725	FW	denotes	vitro
T7904	13726-13732	NNS	denotes	assays
T7905	13732-13733	.	denotes	.
T7906	13733-13916	sentence	denotes	Proprioceptive axons in mice enter the gray matter in the spinal cord and advance ventrally parallel to the midline by E13 and reach the motor neurons by E15 (Ozaki and Snider 1994).
T7907	13734-13748	JJ	denotes	Proprioceptive
T7908	13749-13754	NNS	denotes	axons
T7910	13755-13757	IN	denotes	in
T7911	13758-13762	NNS	denotes	mice
T7909	13763-13768	VBP	denotes	enter
T7912	13769-13772	DT	denotes	the
T7914	13773-13777	JJ	denotes	gray
T7913	13778-13784	NN	denotes	matter
T7915	13785-13787	IN	denotes	in
T7916	13788-13791	DT	denotes	the
T7918	13792-13798	JJ	denotes	spinal
T7917	13799-13803	NN	denotes	cord
T7919	13804-13807	CC	denotes	and
T7920	13808-13815	VBP	denotes	advance
T7921	13816-13825	RB	denotes	ventrally
T7922	13826-13834	RB	denotes	parallel
T7923	13835-13837	IN	denotes	to
T7924	13838-13841	DT	denotes	the
T7925	13842-13849	NN	denotes	midline
T7926	13850-13852	IN	denotes	by
T7927	13853-13856	NN	denotes	E13
T7928	13857-13860	CC	denotes	and
T7929	13861-13866	VBP	denotes	reach
T7930	13867-13870	DT	denotes	the
T7932	13871-13876	NN	denotes	motor
T7931	13877-13884	NNS	denotes	neurons
T7933	13885-13887	IN	denotes	by
T7934	13888-13891	NN	denotes	E15
T7935	13892-13893	-LRB-	denotes	(
T7936	13893-13898	NNP	denotes	Ozaki
T7937	13899-13902	CC	denotes	and
T7938	13903-13909	NNP	denotes	Snider
T7939	13910-13914	CD	denotes	1994
T7940	13914-13915	-RRB-	denotes	)
T7941	13915-13916	.	denotes	.
T7942	13916-14012	sentence	denotes	We co-cultured collagen-embedded E13 WT DRG explants with NT-3-soaked sepharose beads (n = 26).
T7943	13917-13919	PRP	denotes	We
T7944	13920-13931	VBD	denotes	co-cultured
T7945	13932-13940	NN	denotes	collagen
T7947	13940-13941	HYPH	denotes	-
T7946	13941-13949	VBN	denotes	embedded
T7949	13950-13953	NN	denotes	E13
T7950	13954-13956	NN	denotes	WT
T7951	13957-13960	NN	denotes	DRG
T7948	13961-13969	NNS	denotes	explants
T7952	13970-13974	IN	denotes	with
T7953	13975-13977	NN	denotes	NT
T7955	13977-13978	HYPH	denotes	-
T7956	13978-13979	CD	denotes	3
T7957	13979-13980	HYPH	denotes	-
T7954	13980-13986	VBN	denotes	soaked
T7959	13987-13996	NN	denotes	sepharose
T7958	13997-14002	NNS	denotes	beads
T7960	14003-14004	-LRB-	denotes	(
T7962	14004-14005	NN	denotes	n
T7963	14006-14007	SYM	denotes	=
T7961	14008-14010	CD	denotes	26
T7964	14010-14011	-RRB-	denotes	)
T7965	14011-14012	.	denotes	.
T7966	14012-14131	sentence	denotes	Control cultures were set up using bovine serum albumin (BSA)– or phosphate buffer saline (PBS)–soaked beads (n = 12).
T7967	14013-14020	NN	denotes	Control
T7968	14021-14029	NNS	denotes	cultures
T7970	14030-14034	VBD	denotes	were
T7969	14035-14038	VBN	denotes	set
T7971	14039-14041	RP	denotes	up
T7972	14042-14047	VBG	denotes	using
T7973	14048-14054	JJ	denotes	bovine
T7975	14055-14060	NN	denotes	serum
T7974	14061-14068	NN	denotes	albumin
T7977	14069-14070	-LRB-	denotes	(
T7978	14070-14073	NN	denotes	BSA
T7979	14073-14074	-RRB-	denotes	)
T7980	14074-14075	-LRB-	denotes	–
T7981	14076-14078	CC	denotes	or
T7982	14079-14088	NN	denotes	phosphate
T7984	14089-14095	NN	denotes	buffer
T7983	14096-14102	NN	denotes	saline
T7985	14103-14104	-LRB-	denotes	(
T7986	14104-14107	NN	denotes	PBS
T7987	14107-14108	-RRB-	denotes	)
T7988	14108-14109	-RRB-	denotes	–
T7976	14109-14115	VBN	denotes	soaked
T7989	14116-14121	NNS	denotes	beads
T7990	14122-14123	-LRB-	denotes	(
T7992	14123-14124	NN	denotes	n
T7993	14125-14126	SYM	denotes	=
T7991	14127-14129	CD	denotes	12
T7994	14129-14130	-RRB-	denotes	)
T7995	14130-14131	.	denotes	.
T7996	14131-14379	sentence	denotes	DRG axons began extending towards the localized NT-3 source by the end of the first day and consistently displayed a strong chemoattraction by 3 d in vitro, whereas they did not show such preference for BSA-loaded control beads (Figure 5A and 5B).
T7997	14132-14135	NN	denotes	DRG
T7998	14136-14141	NNS	denotes	axons
T7999	14142-14147	VBD	denotes	began
T8000	14148-14157	VBG	denotes	extending
T8001	14158-14165	IN	denotes	towards
T8002	14166-14169	DT	denotes	the
T8004	14170-14179	JJ	denotes	localized
T8005	14180-14182	NN	denotes	NT
T8006	14182-14183	HYPH	denotes	-
T8007	14183-14184	CD	denotes	3
T8003	14185-14191	NN	denotes	source
T8008	14192-14194	IN	denotes	by
T8009	14195-14198	DT	denotes	the
T8010	14199-14202	NN	denotes	end
T8011	14203-14205	IN	denotes	of
T8012	14206-14209	DT	denotes	the
T8014	14210-14215	JJ	denotes	first
T8013	14216-14219	NN	denotes	day
T8015	14220-14223	CC	denotes	and
T8016	14224-14236	RB	denotes	consistently
T8017	14237-14246	VBD	denotes	displayed
T8018	14247-14248	DT	denotes	a
T8020	14249-14255	JJ	denotes	strong
T8019	14256-14271	NN	denotes	chemoattraction
T8021	14272-14274	IN	denotes	by
T8022	14275-14276	CD	denotes	3
T8023	14277-14278	NN	denotes	d
T8024	14279-14281	FW	denotes	in
T8025	14282-14287	FW	denotes	vitro
T8026	14287-14289	,	denotes	,
T8027	14289-14296	IN	denotes	whereas
T8029	14297-14301	PRP	denotes	they
T8030	14302-14305	VBD	denotes	did
T8031	14306-14309	RB	denotes	not
T8028	14310-14314	VB	denotes	show
T8032	14315-14319	JJ	denotes	such
T8033	14320-14330	NN	denotes	preference
T8034	14331-14334	IN	denotes	for
T8035	14335-14338	NN	denotes	BSA
T8037	14338-14339	HYPH	denotes	-
T8036	14339-14345	VBN	denotes	loaded
T8039	14346-14353	NN	denotes	control
T8038	14354-14359	NNS	denotes	beads
T8040	14360-14361	-LRB-	denotes	(
T8042	14361-14367	NN	denotes	Figure
T8041	14368-14370	NN	denotes	5A
T8043	14371-14374	CC	denotes	and
T8044	14375-14377	NN	denotes	5B
T8045	14377-14378	-RRB-	denotes	)
T8046	14378-14379	.	denotes	.
T8047	14379-14516	sentence	denotes	This attraction was not due to survival support of NT-3 because Bax null ganglia displayed the same chemoattraction (Figure 5C; n = 16).
T8048	14380-14384	DT	denotes	This
T8049	14385-14395	NN	denotes	attraction
T8050	14396-14399	VBD	denotes	was
T8051	14400-14403	RB	denotes	not
T8052	14404-14407	IN	denotes	due
T8053	14408-14410	IN	denotes	to
T8054	14411-14419	NN	denotes	survival
T8055	14420-14427	NN	denotes	support
T8056	14428-14430	IN	denotes	of
T8057	14431-14433	NN	denotes	NT
T8058	14433-14434	HYPH	denotes	-
T8059	14434-14435	CD	denotes	3
T8060	14436-14443	IN	denotes	because
T8062	14444-14447	NN	denotes	Bax
T8063	14448-14452	JJ	denotes	null
T8064	14453-14460	NNS	denotes	ganglia
T8061	14461-14470	VBD	denotes	displayed
T8065	14471-14474	DT	denotes	the
T8067	14475-14479	JJ	denotes	same
T8066	14480-14495	NN	denotes	chemoattraction
T8068	14496-14497	-LRB-	denotes	(
T8070	14497-14503	NN	denotes	Figure
T8069	14504-14506	NN	denotes	5C
T8071	14506-14507	:	denotes	;
T8072	14508-14509	NN	denotes	n
T8074	14510-14511	SYM	denotes	=
T8073	14512-14514	CD	denotes	16
T8075	14514-14515	-RRB-	denotes	)
T8076	14515-14516	.	denotes	.
T8077	14516-14565	sentence	denotes	NT-3 may act through either TrkC, or the p75NTR.
T8078	14517-14519	NN	denotes	NT
T8080	14519-14520	HYPH	denotes	-
T8081	14520-14521	CD	denotes	3
T8082	14522-14525	MD	denotes	may
T8079	14526-14529	VB	denotes	act
T8083	14530-14537	IN	denotes	through
T8084	14538-14544	CC	denotes	either
T8085	14545-14549	NN	denotes	TrkC
T8086	14549-14551	,	denotes	,
T8087	14551-14553	CC	denotes	or
T8088	14554-14557	DT	denotes	the
T8089	14558-14564	NN	denotes	p75NTR
T8090	14564-14565	.	denotes	.
T8091	14565-14660	sentence	denotes	We repeated the co-culture experiments with DRG explants derived from p75NTR KO mice (n = 18).
T8092	14566-14568	PRP	denotes	We
T8093	14569-14577	VBD	denotes	repeated
T8094	14578-14581	DT	denotes	the
T8096	14582-14592	NN	denotes	co-culture
T8095	14593-14604	NNS	denotes	experiments
T8097	14605-14609	IN	denotes	with
T8098	14610-14613	NN	denotes	DRG
T8099	14614-14622	NNS	denotes	explants
T8100	14623-14630	VBN	denotes	derived
T8101	14631-14635	IN	denotes	from
T8102	14636-14642	NN	denotes	p75NTR
T8103	14643-14645	NN	denotes	KO
T8104	14646-14650	NNS	denotes	mice
T8105	14651-14652	-LRB-	denotes	(
T8107	14652-14653	NN	denotes	n
T8108	14654-14655	SYM	denotes	=
T8106	14656-14658	CD	denotes	18
T8109	14658-14659	-RRB-	denotes	)
T8110	14659-14660	.	denotes	.
T8111	14660-14754	sentence	denotes	Axons of these ganglia also showed strong chemoattraction towards the NT-3 beads (Figure 5D).
T8112	14661-14666	NNS	denotes	Axons
T8114	14667-14669	IN	denotes	of
T8115	14670-14675	DT	denotes	these
T8116	14676-14683	NNS	denotes	ganglia
T8117	14684-14688	RB	denotes	also
T8113	14689-14695	VBD	denotes	showed
T8118	14696-14702	JJ	denotes	strong
T8119	14703-14718	NN	denotes	chemoattraction
T8120	14719-14726	IN	denotes	towards
T8121	14727-14730	DT	denotes	the
T8123	14731-14733	NN	denotes	NT
T8124	14733-14734	HYPH	denotes	-
T8125	14734-14735	CD	denotes	3
T8122	14736-14741	NNS	denotes	beads
T8126	14742-14743	-LRB-	denotes	(
T8128	14743-14749	NN	denotes	Figure
T8127	14750-14752	NN	denotes	5D
T8129	14752-14753	-RRB-	denotes	)
T8130	14753-14754	.	denotes	.
T8131	14754-14930	sentence	denotes	Finally, we used diffusible TrkC receptors conjugated to IgG constant regions (TrkC-Fc) added to the medium (n = 6) to deplete soluble NT-3 from the collagen gels (Figure 5E).
T8132	14755-14762	RB	denotes	Finally
T8134	14762-14764	,	denotes	,
T8135	14764-14766	PRP	denotes	we
T8133	14767-14771	VBD	denotes	used
T8136	14772-14782	JJ	denotes	diffusible
T8138	14783-14787	NN	denotes	TrkC
T8137	14788-14797	NNS	denotes	receptors
T8139	14798-14808	VBN	denotes	conjugated
T8140	14809-14811	IN	denotes	to
T8141	14812-14815	NN	denotes	IgG
T8143	14816-14824	NN	denotes	constant
T8142	14825-14832	NNS	denotes	regions
T8144	14833-14834	-LRB-	denotes	(
T8146	14834-14838	NN	denotes	TrkC
T8147	14838-14839	HYPH	denotes	-
T8145	14839-14841	NN	denotes	Fc
T8148	14841-14842	-RRB-	denotes	)
T8149	14843-14848	VBN	denotes	added
T8150	14849-14851	IN	denotes	to
T8151	14852-14855	DT	denotes	the
T8152	14856-14862	NN	denotes	medium
T8153	14863-14864	-LRB-	denotes	(
T8155	14864-14865	NN	denotes	n
T8156	14866-14867	SYM	denotes	=
T8154	14868-14869	CD	denotes	6
T8157	14869-14870	-RRB-	denotes	)
T8158	14871-14873	TO	denotes	to
T8159	14874-14881	VB	denotes	deplete
T8160	14882-14889	JJ	denotes	soluble
T8161	14890-14892	NN	denotes	NT
T8162	14892-14893	HYPH	denotes	-
T8163	14893-14894	CD	denotes	3
T8164	14895-14899	IN	denotes	from
T8165	14900-14903	DT	denotes	the
T8167	14904-14912	NN	denotes	collagen
T8166	14913-14917	NNS	denotes	gels
T8168	14918-14919	-LRB-	denotes	(
T8170	14919-14925	NN	denotes	Figure
T8169	14926-14928	NN	denotes	5E
T8171	14928-14929	-RRB-	denotes	)
T8172	14929-14930	.	denotes	.
T8173	14930-15060	sentence	denotes	In the presence of TrkC-Fc the chemoattraction was completely blocked, demonstrating that the effect we see is specific for NT-3.
T8174	14931-14933	IN	denotes	In
T8176	14934-14937	DT	denotes	the
T8177	14938-14946	NN	denotes	presence
T8178	14947-14949	IN	denotes	of
T8179	14950-14954	NN	denotes	TrkC
T8181	14954-14955	HYPH	denotes	-
T8180	14955-14957	NN	denotes	Fc
T8182	14958-14961	DT	denotes	the
T8183	14962-14977	NN	denotes	chemoattraction
T8184	14978-14981	VBD	denotes	was
T8185	14982-14992	RB	denotes	completely
T8175	14993-15000	VBN	denotes	blocked
T8186	15000-15002	,	denotes	,
T8187	15002-15015	VBG	denotes	demonstrating
T8188	15016-15020	IN	denotes	that
T8190	15021-15024	DT	denotes	the
T8191	15025-15031	NN	denotes	effect
T8192	15032-15034	PRP	denotes	we
T8193	15035-15038	VBP	denotes	see
T8189	15039-15041	VBZ	denotes	is
T8194	15042-15050	JJ	denotes	specific
T8195	15051-15054	IN	denotes	for
T8196	15055-15057	NN	denotes	NT
T8197	15057-15058	HYPH	denotes	-
T8198	15058-15059	CD	denotes	3
T8199	15059-15060	.	denotes	.
T8200	15060-15250	sentence	denotes	In order to investigate the active range of our beads, we have repeated the cultures with WT E13 DRGs by placing the beads at increasing distances from the ganglia (n = 4 each) (Figure 5F).
T8201	15061-15063	IN	denotes	In
T8203	15064-15069	NN	denotes	order
T8204	15070-15072	TO	denotes	to
T8205	15073-15084	VB	denotes	investigate
T8206	15085-15088	DT	denotes	the
T8208	15089-15095	JJ	denotes	active
T8207	15096-15101	NN	denotes	range
T8209	15102-15104	IN	denotes	of
T8210	15105-15108	PRP$	denotes	our
T8211	15109-15114	NNS	denotes	beads
T8212	15114-15116	,	denotes	,
T8213	15116-15118	PRP	denotes	we
T8214	15119-15123	VBP	denotes	have
T8202	15124-15132	VBN	denotes	repeated
T8215	15133-15136	DT	denotes	the
T8216	15137-15145	NNS	denotes	cultures
T8217	15146-15150	IN	denotes	with
T8218	15151-15153	NN	denotes	WT
T8220	15154-15157	NN	denotes	E13
T8219	15158-15162	NNS	denotes	DRGs
T8221	15163-15165	IN	denotes	by
T8222	15166-15173	VBG	denotes	placing
T8223	15174-15177	DT	denotes	the
T8224	15178-15183	NNS	denotes	beads
T8225	15184-15186	IN	denotes	at
T8226	15187-15197	VBG	denotes	increasing
T8227	15198-15207	NNS	denotes	distances
T8228	15208-15212	IN	denotes	from
T8229	15213-15216	DT	denotes	the
T8230	15217-15224	NNS	denotes	ganglia
T8231	15225-15226	-LRB-	denotes	(
T8233	15226-15227	NN	denotes	n
T8234	15228-15229	SYM	denotes	=
T8232	15230-15231	CD	denotes	4
T8235	15232-15236	DT	denotes	each
T8236	15236-15237	-RRB-	denotes	)
T8237	15238-15239	-LRB-	denotes	(
T8239	15239-15245	NN	denotes	Figure
T8238	15246-15248	NN	denotes	5F
T8240	15248-15249	-RRB-	denotes	)
T8241	15249-15250	.	denotes	.
T8242	15250-15416	sentence	denotes	There was still preferred growth towards the bead at 1,200μm, the longest distance studied, although the number of axons and the extent of growth were not as robust.
T8243	15251-15256	EX	denotes	There
T8244	15257-15260	VBD	denotes	was
T8245	15261-15266	RB	denotes	still
T8246	15267-15276	JJ	denotes	preferred
T8247	15277-15283	NN	denotes	growth
T8248	15284-15291	IN	denotes	towards
T8249	15292-15295	DT	denotes	the
T8250	15296-15300	NN	denotes	bead
T8251	15301-15303	IN	denotes	at
T8252	15304-15309	CD	denotes	1,200
T8253	15309-15311	NN	denotes	μm
T8254	15311-15313	,	denotes	,
T8255	15313-15316	DT	denotes	the
T8257	15317-15324	JJS	denotes	longest
T8256	15325-15333	NN	denotes	distance
T8258	15334-15341	VBN	denotes	studied
T8259	15341-15343	,	denotes	,
T8260	15343-15351	IN	denotes	although
T8262	15352-15355	DT	denotes	the
T8263	15356-15362	NN	denotes	number
T8264	15363-15365	IN	denotes	of
T8265	15366-15371	NNS	denotes	axons
T8266	15372-15375	CC	denotes	and
T8267	15376-15379	DT	denotes	the
T8268	15380-15386	NN	denotes	extent
T8269	15387-15389	IN	denotes	of
T8270	15390-15396	NN	denotes	growth
T8261	15397-15401	VBD	denotes	were
T8271	15402-15405	RB	denotes	not
T8272	15406-15408	RB	denotes	as
T8273	15409-15415	JJ	denotes	robust
T8274	15415-15416	.	denotes	.
T8275	15416-15576	sentence	denotes	Next, we set up E13 DRG spinal cord explant cultures using NT-3-loaded beads placed at the midline at mid-spinal cord level as an ectopic NT-3 source (n = 15).
T8276	15417-15421	RB	denotes	Next
T8278	15421-15423	,	denotes	,
T8279	15423-15425	PRP	denotes	we
T8277	15426-15429	VBD	denotes	set
T8280	15430-15432	RP	denotes	up
T8281	15433-15436	NN	denotes	E13
T8283	15437-15440	NN	denotes	DRG
T8284	15441-15447	JJ	denotes	spinal
T8285	15448-15452	NN	denotes	cord
T8286	15453-15460	NN	denotes	explant
T8282	15461-15469	NNS	denotes	cultures
T8287	15470-15475	VBG	denotes	using
T8288	15476-15478	NN	denotes	NT
T8290	15478-15479	HYPH	denotes	-
T8291	15479-15480	CD	denotes	3
T8292	15480-15481	HYPH	denotes	-
T8289	15481-15487	VBN	denotes	loaded
T8293	15488-15493	NNS	denotes	beads
T8294	15494-15500	VBN	denotes	placed
T8295	15501-15503	IN	denotes	at
T8296	15504-15507	DT	denotes	the
T8297	15508-15515	NN	denotes	midline
T8298	15516-15518	IN	denotes	at
T8299	15519-15529	JJ	denotes	mid-spinal
T8301	15530-15534	NN	denotes	cord
T8300	15535-15540	NN	denotes	level
T8302	15541-15543	IN	denotes	as
T8303	15544-15546	DT	denotes	an
T8305	15547-15554	JJ	denotes	ectopic
T8306	15555-15557	NN	denotes	NT
T8307	15557-15558	HYPH	denotes	-
T8308	15558-15559	CD	denotes	3
T8304	15560-15566	NN	denotes	source
T8309	15567-15568	-LRB-	denotes	(
T8311	15568-15569	NN	denotes	n
T8312	15570-15571	SYM	denotes	=
T8310	15572-15574	CD	denotes	15
T8313	15574-15575	-RRB-	denotes	)
T8314	15575-15576	.	denotes	.
T8315	15576-15634	sentence	denotes	Control cultures were set using PBS-loaded beads (n = 6).
T8316	15577-15584	NN	denotes	Control
T8317	15585-15593	NNS	denotes	cultures
T8319	15594-15598	VBD	denotes	were
T8318	15599-15602	VBN	denotes	set
T8320	15603-15608	VBG	denotes	using
T8321	15609-15612	NN	denotes	PBS
T8323	15612-15613	HYPH	denotes	-
T8322	15613-15619	VBN	denotes	loaded
T8324	15620-15625	NNS	denotes	beads
T8325	15626-15627	-LRB-	denotes	(
T8327	15627-15628	NN	denotes	n
T8328	15629-15630	SYM	denotes	=
T8326	15631-15632	CD	denotes	6
T8329	15632-15633	-RRB-	denotes	)
T8330	15633-15634	.	denotes	.
T8331	15634-15851	sentence	denotes	DiI labeling through the DRGs revealed numerous fibers entering the spinal cord at ectopic regions and growing towards the NT-3 beads (Figure 6A), surrounding the beads and forming bundles around them (Figure 6C–6E).
T8332	15635-15638	NN	denotes	DiI
T8333	15639-15647	NN	denotes	labeling
T8335	15648-15655	IN	denotes	through
T8336	15656-15659	DT	denotes	the
T8337	15660-15664	NNS	denotes	DRGs
T8334	15665-15673	VBD	denotes	revealed
T8338	15674-15682	JJ	denotes	numerous
T8339	15683-15689	NNS	denotes	fibers
T8340	15690-15698	VBG	denotes	entering
T8341	15699-15702	DT	denotes	the
T8343	15703-15709	JJ	denotes	spinal
T8342	15710-15714	NN	denotes	cord
T8344	15715-15717	IN	denotes	at
T8345	15718-15725	JJ	denotes	ectopic
T8346	15726-15733	NNS	denotes	regions
T8347	15734-15737	CC	denotes	and
T8348	15738-15745	VBG	denotes	growing
T8349	15746-15753	IN	denotes	towards
T8350	15754-15757	DT	denotes	the
T8352	15758-15760	NN	denotes	NT
T8353	15760-15761	HYPH	denotes	-
T8354	15761-15762	CD	denotes	3
T8351	15763-15768	NNS	denotes	beads
T8355	15769-15770	-LRB-	denotes	(
T8357	15770-15776	NN	denotes	Figure
T8356	15777-15779	NN	denotes	6A
T8358	15779-15780	-RRB-	denotes	)
T8359	15780-15782	,	denotes	,
T8360	15782-15793	VBG	denotes	surrounding
T8361	15794-15797	DT	denotes	the
T8362	15798-15803	NNS	denotes	beads
T8363	15804-15807	CC	denotes	and
T8364	15808-15815	VBG	denotes	forming
T8365	15816-15823	NNS	denotes	bundles
T8366	15824-15830	IN	denotes	around
T8367	15831-15835	PRP	denotes	them
T8368	15836-15837	-LRB-	denotes	(
T8370	15837-15843	NN	denotes	Figure
T8369	15844-15846	NN	denotes	6C
T8371	15846-15847	SYM	denotes	–
T8372	15847-15849	NN	denotes	6E
T8373	15849-15850	-RRB-	denotes	)
T8374	15850-15851	.	denotes	.
T8375	15851-16020	sentence	denotes	In control cultures, all labeled fibers were directed towards the dorsal spinal cord and terminated there, where they normally enter the gray matter at E13 (Figure 6B).
T8376	15852-15854	IN	denotes	In
T8378	15855-15862	NN	denotes	control
T8379	15863-15871	NNS	denotes	cultures
T8380	15871-15873	,	denotes	,
T8381	15873-15876	DT	denotes	all
T8383	15877-15884	VBN	denotes	labeled
T8382	15885-15891	NNS	denotes	fibers
T8384	15892-15896	VBD	denotes	were
T8377	15897-15905	VBN	denotes	directed
T8385	15906-15913	IN	denotes	towards
T8386	15914-15917	DT	denotes	the
T8388	15918-15924	JJ	denotes	dorsal
T8389	15925-15931	JJ	denotes	spinal
T8387	15932-15936	NN	denotes	cord
T8390	15937-15940	CC	denotes	and
T8391	15941-15951	VBN	denotes	terminated
T8392	15952-15957	RB	denotes	there
T8393	15957-15959	,	denotes	,
T8394	15959-15964	WRB	denotes	where
T8396	15965-15969	PRP	denotes	they
T8397	15970-15978	RB	denotes	normally
T8395	15979-15984	VBP	denotes	enter
T8398	15985-15988	DT	denotes	the
T8400	15989-15993	JJ	denotes	gray
T8399	15994-16000	NN	denotes	matter
T8401	16001-16003	IN	denotes	at
T8402	16004-16007	NN	denotes	E13
T8403	16008-16009	-LRB-	denotes	(
T8405	16009-16015	NN	denotes	Figure
T8404	16016-16018	NN	denotes	6B
T8406	16018-16019	-RRB-	denotes	)
T8407	16019-16020	.	denotes	.
T8408	16020-16092	sentence	denotes	No axons were observed around the PBS-loaded control beads (Figure 6F).
T8409	16021-16023	DT	denotes	No
T8410	16024-16029	NNS	denotes	axons
T8412	16030-16034	VBD	denotes	were
T8411	16035-16043	VBN	denotes	observed
T8413	16044-16050	IN	denotes	around
T8414	16051-16054	DT	denotes	the
T8416	16055-16058	NN	denotes	PBS
T8418	16058-16059	HYPH	denotes	-
T8417	16059-16065	VBN	denotes	loaded
T8419	16066-16073	NN	denotes	control
T8415	16074-16079	NNS	denotes	beads
T8420	16080-16081	-LRB-	denotes	(
T8422	16081-16087	NN	denotes	Figure
T8421	16088-16090	NN	denotes	6F
T8423	16090-16091	-RRB-	denotes	)
T8424	16091-16092	.	denotes	.
T8425	16092-16378	sentence	denotes	Axons that normally enter the gray matter through dorsal spinal cord grow towards the midline when presented with a localized NT-3 source, and new axon growth towards the NT-3 bead is initiated from DRGs, entering the spinal cord at ectopic loci at lateral mid-spinal cord (Figure 6G).
T8426	16093-16098	NNS	denotes	Axons
T8428	16099-16103	WDT	denotes	that
T8430	16104-16112	RB	denotes	normally
T8429	16113-16118	VBP	denotes	enter
T8431	16119-16122	DT	denotes	the
T8433	16123-16127	JJ	denotes	gray
T8432	16128-16134	NN	denotes	matter
T8434	16135-16142	IN	denotes	through
T8435	16143-16149	JJ	denotes	dorsal
T8437	16150-16156	JJ	denotes	spinal
T8436	16157-16161	NN	denotes	cord
T8427	16162-16166	VBP	denotes	grow
T8438	16167-16174	IN	denotes	towards
T8439	16175-16178	DT	denotes	the
T8440	16179-16186	NN	denotes	midline
T8441	16187-16191	WRB	denotes	when
T8442	16192-16201	VBN	denotes	presented
T8443	16202-16206	IN	denotes	with
T8444	16207-16208	DT	denotes	a
T8446	16209-16218	JJ	denotes	localized
T8447	16219-16221	NN	denotes	NT
T8448	16221-16222	HYPH	denotes	-
T8449	16222-16223	CD	denotes	3
T8445	16224-16230	NN	denotes	source
T8450	16230-16232	,	denotes	,
T8451	16232-16235	CC	denotes	and
T8452	16236-16239	JJ	denotes	new
T8454	16240-16244	NN	denotes	axon
T8453	16245-16251	NN	denotes	growth
T8456	16252-16259	IN	denotes	towards
T8457	16260-16263	DT	denotes	the
T8459	16264-16266	NN	denotes	NT
T8460	16266-16267	HYPH	denotes	-
T8461	16267-16268	CD	denotes	3
T8458	16269-16273	NN	denotes	bead
T8462	16274-16276	VBZ	denotes	is
T8455	16277-16286	VBN	denotes	initiated
T8463	16287-16291	IN	denotes	from
T8464	16292-16296	NNS	denotes	DRGs
T8465	16296-16298	,	denotes	,
T8466	16298-16306	VBG	denotes	entering
T8467	16307-16310	DT	denotes	the
T8469	16311-16317	JJ	denotes	spinal
T8468	16318-16322	NN	denotes	cord
T8470	16323-16325	IN	denotes	at
T8471	16326-16333	JJ	denotes	ectopic
T8472	16334-16338	NNS	denotes	loci
T8473	16339-16341	IN	denotes	at
T8474	16342-16349	JJ	denotes	lateral
T8476	16350-16360	JJ	denotes	mid-spinal
T8475	16361-16365	NN	denotes	cord
T8477	16366-16367	-LRB-	denotes	(
T8479	16367-16373	NN	denotes	Figure
T8478	16374-16376	NN	denotes	6G
T8480	16376-16377	-RRB-	denotes	)
T8481	16377-16378	.	denotes	.
T8482	16378-16450	sentence	denotes	NT-3 is therefore capable of acting as a chemoattractant for DRG axons.
T8483	16379-16381	NN	denotes	NT
T8485	16381-16382	HYPH	denotes	-
T8486	16382-16383	CD	denotes	3
T8484	16384-16386	VBZ	denotes	is
T8487	16387-16396	RB	denotes	therefore
T8488	16397-16404	JJ	denotes	capable
T8489	16405-16407	IN	denotes	of
T8490	16408-16414	VBG	denotes	acting
T8491	16415-16417	IN	denotes	as
T8492	16418-16419	DT	denotes	a
T8493	16420-16435	NN	denotes	chemoattractant
T8494	16436-16439	IN	denotes	for
T8495	16440-16443	NN	denotes	DRG
T8496	16444-16449	NNS	denotes	axons
T8497	16449-16450	.	denotes	.
T13384	18296-18306	RB	denotes	Relatively
T13386	18307-18310	JJ	denotes	few
T13385	18311-18318	NNS	denotes	studies
T13388	18319-18323	VBP	denotes	have
T13387	18324-18334	VBN	denotes	implicated
T13389	18335-18337	NN	denotes	NT
T13390	18337-18338	HYPH	denotes	-
T13391	18338-18339	CD	denotes	3
T13392	18340-18342	IN	denotes	as
T13393	18343-18344	DT	denotes	a
T13395	18345-18360	JJ	denotes	chemoattractant
T13394	18361-18366	NN	denotes	agent
T13396	18367-18370	IN	denotes	for
T13397	18371-18378	JJ	denotes	sensory
T13399	18379-18382	CC	denotes	and
T13400	18383-18388	NN	denotes	motor
T13398	18389-18394	NNS	denotes	axons
T13401	18394-18395	.	denotes	.
T13402	18395-18628	sentence	denotes	Previously noted chemoattractant action of the embryonic mouse maxillary process on trigeminal ganglion neurons (Lumsden and Davies 1986) is now attributed to NT-3 and brain-derived neurotrophic factor (BDNF) (O'Connor et al. 1999).
T13403	18396-18406	RB	denotes	Previously
T13404	18407-18412	VBN	denotes	noted
T13406	18413-18428	NN	denotes	chemoattractant
T13405	18429-18435	NN	denotes	action
T13408	18436-18438	IN	denotes	of
T13409	18439-18442	DT	denotes	the
T13411	18443-18452	JJ	denotes	embryonic
T13412	18453-18458	NN	denotes	mouse
T13413	18459-18468	JJ	denotes	maxillary
T13410	18469-18476	NN	denotes	process
T13414	18477-18479	IN	denotes	on
T13415	18480-18490	JJ	denotes	trigeminal
T13417	18491-18499	NN	denotes	ganglion
T13416	18500-18507	NNS	denotes	neurons
T13418	18508-18509	-LRB-	denotes	(
T13419	18509-18516	NNP	denotes	Lumsden
T13420	18517-18520	CC	denotes	and
T13421	18521-18527	NNP	denotes	Davies
T13422	18528-18532	CD	denotes	1986
T13423	18532-18533	-RRB-	denotes	)
T13424	18534-18536	VBZ	denotes	is
T13425	18537-18540	RB	denotes	now
T13407	18541-18551	VBN	denotes	attributed
T13426	18552-18554	IN	denotes	to
T13427	18555-18557	NN	denotes	NT
T13428	18557-18558	HYPH	denotes	-
T13429	18558-18559	CD	denotes	3
T13430	18560-18563	CC	denotes	and
T13431	18564-18569	NN	denotes	brain
T13433	18569-18570	HYPH	denotes	-
T13432	18570-18577	VBN	denotes	derived
T13435	18578-18590	JJ	denotes	neurotrophic
T13434	18591-18597	NN	denotes	factor
T13436	18598-18599	-LRB-	denotes	(
T13437	18599-18603	NN	denotes	BDNF
T13438	18603-18604	-RRB-	denotes	)
T13439	18605-18606	-LRB-	denotes	(
T13440	18606-18614	NNP	denotes	O'Connor
T13441	18615-18617	FW	denotes	et
T13442	18618-18621	FW	denotes	al.
T13443	18622-18626	CD	denotes	1999
T13444	18626-18627	-RRB-	denotes	)
T13445	18627-18628	.	denotes	.
T13446	18628-18831	sentence	denotes	Recently, Tucker et al. (2001) showed that developing sensory and motor axons in limb slice cultures preferentially grow towards neurotrophin-soaked beads instead of following their normal trajectories.
T13447	18629-18637	RB	denotes	Recently
T13449	18637-18639	,	denotes	,
T13450	18639-18645	NNP	denotes	Tucker
T13451	18646-18648	FW	denotes	et
T13452	18649-18652	FW	denotes	al.
T13453	18653-18654	-LRB-	denotes	(
T13454	18654-18658	CD	denotes	2001
T13455	18658-18659	-RRB-	denotes	)
T13448	18660-18666	VBD	denotes	showed
T13456	18667-18671	IN	denotes	that
T13458	18672-18682	JJ	denotes	developing
T13460	18683-18690	JJ	denotes	sensory
T13461	18691-18694	CC	denotes	and
T13462	18695-18700	JJ	denotes	motor
T13459	18701-18706	NNS	denotes	axons
T13463	18707-18709	IN	denotes	in
T13464	18710-18714	NN	denotes	limb
T13465	18715-18720	NN	denotes	slice
T13466	18721-18729	NNS	denotes	cultures
T13467	18730-18744	RB	denotes	preferentially
T13457	18745-18749	VBP	denotes	grow
T13468	18750-18757	IN	denotes	towards
T13469	18758-18770	NN	denotes	neurotrophin
T13471	18770-18771	HYPH	denotes	-
T13470	18771-18777	VBN	denotes	soaked
T13472	18778-18783	NNS	denotes	beads
T13473	18784-18791	RB	denotes	instead
T13474	18792-18794	IN	denotes	of
T13475	18795-18804	VBG	denotes	following
T13476	18805-18810	PRP$	denotes	their
T13478	18811-18817	JJ	denotes	normal
T13477	18818-18830	NNS	denotes	trajectories
T13479	18830-18831	.	denotes	.
T13480	18831-18971	sentence	denotes	Conversely, beads soaked with neurotrophin function-blocking antibodies led to reduction of sensory and motor axon growth towards the limb.
T13481	18832-18842	RB	denotes	Conversely
T13483	18842-18844	,	denotes	,
T13484	18844-18849	NNS	denotes	beads
T13485	18850-18856	VBN	denotes	soaked
T13486	18857-18861	IN	denotes	with
T13487	18862-18874	NN	denotes	neurotrophin
T13489	18875-18883	NN	denotes	function
T13491	18883-18884	HYPH	denotes	-
T13490	18884-18892	VBG	denotes	blocking
T13488	18893-18903	NNS	denotes	antibodies
T13482	18904-18907	VBD	denotes	led
T13492	18908-18910	IN	denotes	to
T13493	18911-18920	NN	denotes	reduction
T13494	18921-18923	IN	denotes	of
T13495	18924-18931	JJ	denotes	sensory
T13497	18932-18935	CC	denotes	and
T13498	18936-18941	JJ	denotes	motor
T13499	18942-18946	NN	denotes	axon
T13496	18947-18953	NN	denotes	growth
T13500	18954-18961	IN	denotes	towards
T13501	18962-18965	DT	denotes	the
T13502	18966-18970	NN	denotes	limb
T13503	18970-18971	.	denotes	.
T13504	18971-19248	sentence	denotes	In transgenic mice, which over-express NT-3 under the nestin promoter in the central nervous system, the course of the proprioceptive afferents are altered and directed towards the regions with high levels of ectopic NT-3 expression in the spinal cord (Ringstedt et al. 1997).
T13505	18972-18974	IN	denotes	In
T13507	18975-18985	JJ	denotes	transgenic
T13508	18986-18990	NNS	denotes	mice
T13509	18990-18992	,	denotes	,
T13510	18992-18997	WDT	denotes	which
T13511	18998-19010	VBP	denotes	over-express
T13512	19011-19013	NN	denotes	NT
T13513	19013-19014	HYPH	denotes	-
T13514	19014-19015	CD	denotes	3
T13515	19016-19021	IN	denotes	under
T13516	19022-19025	DT	denotes	the
T13518	19026-19032	NN	denotes	nestin
T13517	19033-19041	NN	denotes	promoter
T13519	19042-19044	IN	denotes	in
T13520	19045-19048	DT	denotes	the
T13522	19049-19056	JJ	denotes	central
T13523	19057-19064	JJ	denotes	nervous
T13521	19065-19071	NN	denotes	system
T13524	19071-19073	,	denotes	,
T13525	19073-19076	DT	denotes	the
T13526	19077-19083	NN	denotes	course
T13527	19084-19086	IN	denotes	of
T13528	19087-19090	DT	denotes	the
T13530	19091-19105	JJ	denotes	proprioceptive
T13529	19106-19115	NNS	denotes	afferents
T13531	19116-19119	VBP	denotes	are
T13506	19120-19127	VBN	denotes	altered
T13532	19128-19131	CC	denotes	and
T13533	19132-19140	VBN	denotes	directed
T13534	19141-19148	IN	denotes	towards
T13535	19149-19152	DT	denotes	the
T13536	19153-19160	NNS	denotes	regions
T13537	19161-19165	IN	denotes	with
T13538	19166-19170	JJ	denotes	high
T13539	19171-19177	NNS	denotes	levels
T13540	19178-19180	IN	denotes	of
T13541	19181-19188	JJ	denotes	ectopic
T13543	19189-19191	NN	denotes	NT
T13544	19191-19192	HYPH	denotes	-
T13545	19192-19193	CD	denotes	3
T13542	19194-19204	NN	denotes	expression
T13546	19205-19207	IN	denotes	in
T13547	19208-19211	DT	denotes	the
T13549	19212-19218	JJ	denotes	spinal
T13548	19219-19223	NN	denotes	cord
T13550	19224-19225	-LRB-	denotes	(
T13551	19225-19234	NNP	denotes	Ringstedt
T13552	19235-19237	FW	denotes	et
T13553	19238-19241	FW	denotes	al.
T13554	19242-19246	CD	denotes	1997
T13555	19246-19247	-RRB-	denotes	)
T13556	19247-19248	.	denotes	.
T13557	19248-19403	sentence	denotes	Ringstedt et al. considered the possibility that NT-3 may play a chemoattractant role during the innervation of ventral horns by proprioceptive afferents.
T13558	19249-19258	NNP	denotes	Ringstedt
T13560	19259-19261	FW	denotes	et
T13561	19262-19265	FW	denotes	al.
T13559	19266-19276	VBD	denotes	considered
T13562	19277-19280	DT	denotes	the
T13563	19281-19292	NN	denotes	possibility
T13564	19293-19297	IN	denotes	that
T13566	19298-19300	NN	denotes	NT
T13567	19300-19301	HYPH	denotes	-
T13568	19301-19302	CD	denotes	3
T13569	19303-19306	MD	denotes	may
T13565	19307-19311	VB	denotes	play
T13570	19312-19313	DT	denotes	a
T13572	19314-19329	NN	denotes	chemoattractant
T13571	19330-19334	NN	denotes	role
T13573	19335-19341	IN	denotes	during
T13574	19342-19345	DT	denotes	the
T13575	19346-19357	NN	denotes	innervation
T13576	19358-19360	IN	denotes	of
T13577	19361-19368	JJ	denotes	ventral
T13578	19369-19374	NNS	denotes	horns
T13579	19375-19377	IN	denotes	by
T13580	19378-19392	JJ	denotes	proprioceptive
T13581	19393-19402	NNS	denotes	afferents
T13582	19402-19403	.	denotes	.
T13583	19403-19629	sentence	denotes	However, earlier findings of normal proprioceptive afferent trajectories in chicken embryos despite injection of function-blocking NT-3 antibody into the spinal cord (Oakley et al. 1995) led them to discount this possibility.
T13584	19404-19411	RB	denotes	However
T13586	19411-19413	,	denotes	,
T13587	19413-19420	JJR	denotes	earlier
T13588	19421-19429	NNS	denotes	findings
T13589	19430-19432	IN	denotes	of
T13590	19433-19439	JJ	denotes	normal
T13592	19440-19454	JJ	denotes	proprioceptive
T13593	19455-19463	JJ	denotes	afferent
T13591	19464-19476	NNS	denotes	trajectories
T13594	19477-19479	IN	denotes	in
T13595	19480-19487	NN	denotes	chicken
T13596	19488-19495	NNS	denotes	embryos
T13597	19496-19503	IN	denotes	despite
T13598	19504-19513	NN	denotes	injection
T13599	19514-19516	IN	denotes	of
T13600	19517-19525	NN	denotes	function
T13602	19525-19526	HYPH	denotes	-
T13601	19526-19534	VBG	denotes	blocking
T13604	19535-19537	NN	denotes	NT
T13605	19537-19538	HYPH	denotes	-
T13606	19538-19539	CD	denotes	3
T13603	19540-19548	NN	denotes	antibody
T13607	19549-19553	IN	denotes	into
T13608	19554-19557	DT	denotes	the
T13610	19558-19564	JJ	denotes	spinal
T13609	19565-19569	NN	denotes	cord
T13611	19570-19571	-LRB-	denotes	(
T13612	19571-19577	NNP	denotes	Oakley
T13613	19578-19580	FW	denotes	et
T13614	19581-19584	FW	denotes	al.
T13615	19585-19589	CD	denotes	1995
T13616	19589-19590	-RRB-	denotes	)
T13585	19591-19594	VBD	denotes	led
T13617	19595-19599	PRP	denotes	them
T13618	19600-19602	TO	denotes	to
T13619	19603-19611	VB	denotes	discount
T13620	19612-19616	DT	denotes	this
T13621	19617-19628	NN	denotes	possibility
T13622	19628-19629	.	denotes	.
T13623	19629-19838	sentence	denotes	In that study, though, assays on the effectiveness of antibody perturbation on NT-3-dependent cell survival showed that effectiveness was significant (approximately 90%) but not complete (Oakley et al. 1995).
T13624	19630-19632	IN	denotes	In
T13626	19633-19637	DT	denotes	that
T13627	19638-19643	NN	denotes	study
T13628	19643-19645	,	denotes	,
T13629	19645-19651	RB	denotes	though
T13630	19651-19653	,	denotes	,
T13631	19653-19659	NNS	denotes	assays
T13632	19660-19662	IN	denotes	on
T13633	19663-19666	DT	denotes	the
T13634	19667-19680	NN	denotes	effectiveness
T13635	19681-19683	IN	denotes	of
T13636	19684-19692	NN	denotes	antibody
T13637	19693-19705	NN	denotes	perturbation
T13638	19706-19708	IN	denotes	on
T13639	19709-19711	NN	denotes	NT
T13641	19711-19712	HYPH	denotes	-
T13642	19712-19713	CD	denotes	3
T13643	19713-19714	HYPH	denotes	-
T13640	19714-19723	JJ	denotes	dependent
T13645	19724-19728	NN	denotes	cell
T13644	19729-19737	NN	denotes	survival
T13625	19738-19744	VBD	denotes	showed
T13646	19745-19749	IN	denotes	that
T13648	19750-19763	NN	denotes	effectiveness
T13647	19764-19767	VBD	denotes	was
T13649	19768-19779	JJ	denotes	significant
T13650	19780-19781	-LRB-	denotes	(
T13652	19781-19794	RB	denotes	approximately
T13653	19795-19797	CD	denotes	90
T13651	19797-19798	NN	denotes	%
T13654	19798-19799	-RRB-	denotes	)
T13655	19800-19803	CC	denotes	but
T13656	19804-19807	RB	denotes	not
T13657	19808-19816	JJ	denotes	complete
T13658	19817-19818	-LRB-	denotes	(
T13659	19818-19824	NNP	denotes	Oakley
T13660	19825-19827	FW	denotes	et
T13661	19828-19831	FW	denotes	al.
T13662	19832-19836	CD	denotes	1995
T13663	19836-19837	-RRB-	denotes	)
T13664	19837-19838	.	denotes	.
T13665	19838-20006	sentence	denotes	Ringstedt et al. (1997) argue that while central sensory axons may still navigate properly in the absence of NT-3, ectopic expression of NT-3 disrupts their targeting.
T13666	19839-19848	NNP	denotes	Ringstedt
T13668	19849-19851	FW	denotes	et
T13669	19852-19855	FW	denotes	al.
T13670	19856-19857	-LRB-	denotes	(
T13671	19857-19861	CD	denotes	1997
T13672	19861-19862	-RRB-	denotes	)
T13667	19863-19868	VBP	denotes	argue
T13673	19869-19873	IN	denotes	that
T13675	19874-19879	IN	denotes	while
T13677	19880-19887	JJ	denotes	central
T13679	19888-19895	JJ	denotes	sensory
T13678	19896-19901	NNS	denotes	axons
T13680	19902-19905	MD	denotes	may
T13681	19906-19911	RB	denotes	still
T13676	19912-19920	VB	denotes	navigate
T13682	19921-19929	RB	denotes	properly
T13683	19930-19932	IN	denotes	in
T13684	19933-19936	DT	denotes	the
T13685	19937-19944	NN	denotes	absence
T13686	19945-19947	IN	denotes	of
T13687	19948-19950	NN	denotes	NT
T13688	19950-19951	HYPH	denotes	-
T13689	19951-19952	CD	denotes	3
T13690	19952-19954	,	denotes	,
T13691	19954-19961	JJ	denotes	ectopic
T13692	19962-19972	NN	denotes	expression
T13693	19973-19975	IN	denotes	of
T13694	19976-19978	NN	denotes	NT
T13695	19978-19979	HYPH	denotes	-
T13696	19979-19980	CD	denotes	3
T13674	19981-19989	VBZ	denotes	disrupts
T13697	19990-19995	PRP$	denotes	their
T13698	19996-20005	NN	denotes	targeting
T13699	20005-20006	.	denotes	.
T13700	20006-20172	sentence	denotes	Recently, another member of the neurotrophin family, BDNF, has been suggested to act as a chemoattractant for sensory axons innervating ear (Tessarollo et al. 2004).
T13701	20007-20015	RB	denotes	Recently
T13703	20015-20017	,	denotes	,
T13704	20017-20024	DT	denotes	another
T13705	20025-20031	NN	denotes	member
T13706	20032-20034	IN	denotes	of
T13707	20035-20038	DT	denotes	the
T13709	20039-20051	NN	denotes	neurotrophin
T13708	20052-20058	NN	denotes	family
T13710	20058-20060	,	denotes	,
T13711	20060-20064	NN	denotes	BDNF
T13712	20064-20066	,	denotes	,
T13713	20066-20069	VBZ	denotes	has
T13714	20070-20074	VBN	denotes	been
T13702	20075-20084	VBN	denotes	suggested
T13715	20085-20087	TO	denotes	to
T13716	20088-20091	VB	denotes	act
T13717	20092-20094	IN	denotes	as
T13718	20095-20096	DT	denotes	a
T13719	20097-20112	NN	denotes	chemoattractant
T13720	20113-20116	IN	denotes	for
T13721	20117-20124	JJ	denotes	sensory
T13722	20125-20130	NNS	denotes	axons
T13724	20131-20142	VBG	denotes	innervating
T13723	20143-20146	NN	denotes	ear
T13725	20147-20148	-LRB-	denotes	(
T13726	20148-20158	NNP	denotes	Tessarollo
T13727	20159-20161	FW	denotes	et
T13728	20162-20165	FW	denotes	al.
T13729	20166-20170	CD	denotes	2004
T13730	20170-20171	-RRB-	denotes	)
T13731	20171-20172	.	denotes	.
T13732	20172-20403	sentence	denotes	In a gene replacement strategy in which BDNF expression was driven by the NT-3 promoter, vestibular axons rerouted towards ectopic sources of BDNF in the cochlea that normally expressed NT-3 and were not innervated by these axons.
T13733	20173-20175	IN	denotes	In
T13735	20176-20177	DT	denotes	a
T13737	20178-20182	NN	denotes	gene
T13738	20183-20194	NN	denotes	replacement
T13736	20195-20203	NN	denotes	strategy
T13739	20204-20206	IN	denotes	in
T13741	20207-20212	WDT	denotes	which
T13742	20213-20217	NN	denotes	BDNF
T13743	20218-20228	NN	denotes	expression
T13744	20229-20232	VBD	denotes	was
T13740	20233-20239	VBN	denotes	driven
T13745	20240-20242	IN	denotes	by
T13746	20243-20246	DT	denotes	the
T13748	20247-20249	NN	denotes	NT
T13749	20249-20250	HYPH	denotes	-
T13750	20250-20251	CD	denotes	3
T13747	20252-20260	NN	denotes	promoter
T13751	20260-20262	,	denotes	,
T13752	20262-20272	JJ	denotes	vestibular
T13753	20273-20278	NNS	denotes	axons
T13734	20279-20287	VBP	denotes	rerouted
T13754	20288-20295	IN	denotes	towards
T13755	20296-20303	JJ	denotes	ectopic
T13756	20304-20311	NNS	denotes	sources
T13757	20312-20314	IN	denotes	of
T13758	20315-20319	NN	denotes	BDNF
T13759	20320-20322	IN	denotes	in
T13760	20323-20326	DT	denotes	the
T13761	20327-20334	NN	denotes	cochlea
T13762	20335-20339	WDT	denotes	that
T13764	20340-20348	RB	denotes	normally
T13763	20349-20358	VBD	denotes	expressed
T13765	20359-20361	NN	denotes	NT
T13766	20361-20362	HYPH	denotes	-
T13767	20362-20363	CD	denotes	3
T13768	20364-20367	CC	denotes	and
T13769	20368-20372	VBD	denotes	were
T13771	20373-20376	RB	denotes	not
T13770	20377-20387	VBN	denotes	innervated
T13772	20388-20390	IN	denotes	by
T13773	20391-20396	DT	denotes	these
T13774	20397-20402	NNS	denotes	axons
T13775	20402-20403	.	denotes	.
T13776	20403-20838	sentence	denotes	Ectopic NT-3 supplied using osmotic pumps and adenovirus-mediated expression induce sensory axon growth during regeneration (Zhang et al. 1998, Bradbury et al. 1999, Oudega et al. 1999, Ramer et al. 2002), and induce axonal plasticity of corticospinal axons in injured adult spinal cord (Zhou et al. 2003), where the sprouting axons from the intact site cross the midline towards the NT-3 source on the lesion side of the spinal cord.
T13777	20404-20411	JJ	denotes	Ectopic
T13778	20412-20414	NN	denotes	NT
T13780	20414-20415	HYPH	denotes	-
T13781	20415-20416	CD	denotes	3
T13782	20417-20425	VBN	denotes	supplied
T13783	20426-20431	VBG	denotes	using
T13784	20432-20439	JJ	denotes	osmotic
T13785	20440-20445	NNS	denotes	pumps
T13786	20446-20449	CC	denotes	and
T13787	20450-20460	NN	denotes	adenovirus
T13789	20460-20461	HYPH	denotes	-
T13788	20461-20469	VBN	denotes	mediated
T13790	20470-20480	NN	denotes	expression
T13779	20481-20487	VBP	denotes	induce
T13791	20488-20495	JJ	denotes	sensory
T13793	20496-20500	NN	denotes	axon
T13792	20501-20507	NN	denotes	growth
T13794	20508-20514	IN	denotes	during
T13795	20515-20527	NN	denotes	regeneration
T13796	20528-20529	-LRB-	denotes	(
T13797	20529-20534	NNP	denotes	Zhang
T13798	20535-20537	FW	denotes	et
T13799	20538-20541	FW	denotes	al.
T13800	20542-20546	CD	denotes	1998
T13801	20546-20548	,	denotes	,
T13802	20548-20556	NNP	denotes	Bradbury
T13803	20557-20559	FW	denotes	et
T13804	20560-20563	FW	denotes	al.
T13805	20564-20568	CD	denotes	1999
T13806	20568-20570	,	denotes	,
T13807	20570-20576	NNP	denotes	Oudega
T13808	20577-20579	FW	denotes	et
T13809	20580-20583	FW	denotes	al.
T13810	20584-20588	CD	denotes	1999
T13811	20588-20590	,	denotes	,
T13812	20590-20595	NNP	denotes	Ramer
T13813	20596-20598	FW	denotes	et
T13814	20599-20602	FW	denotes	al.
T13815	20603-20607	CD	denotes	2002
T13816	20607-20608	-RRB-	denotes	)
T13817	20608-20610	,	denotes	,
T13818	20610-20613	CC	denotes	and
T13819	20614-20620	VBP	denotes	induce
T13820	20621-20627	JJ	denotes	axonal
T13821	20628-20638	NN	denotes	plasticity
T13822	20639-20641	IN	denotes	of
T13823	20642-20655	JJ	denotes	corticospinal
T13824	20656-20661	NNS	denotes	axons
T13825	20662-20664	IN	denotes	in
T13826	20665-20672	VBN	denotes	injured
T13828	20673-20678	JJ	denotes	adult
T13829	20679-20685	JJ	denotes	spinal
T13827	20686-20690	NN	denotes	cord
T13830	20691-20692	-LRB-	denotes	(
T13831	20692-20696	NNP	denotes	Zhou
T13832	20697-20699	FW	denotes	et
T13833	20700-20703	FW	denotes	al.
T13834	20704-20708	CD	denotes	2003
T13835	20708-20709	-RRB-	denotes	)
T13836	20709-20711	,	denotes	,
T13837	20711-20716	WRB	denotes	where
T13839	20717-20720	DT	denotes	the
T13841	20721-20730	VBG	denotes	sprouting
T13840	20731-20736	NNS	denotes	axons
T13842	20737-20741	IN	denotes	from
T13843	20742-20745	DT	denotes	the
T13845	20746-20752	JJ	denotes	intact
T13844	20753-20757	NN	denotes	site
T13838	20758-20763	VBP	denotes	cross
T13846	20764-20767	DT	denotes	the
T13847	20768-20775	NN	denotes	midline
T13848	20776-20783	IN	denotes	towards
T13849	20784-20787	DT	denotes	the
T13851	20788-20790	NN	denotes	NT
T13852	20790-20791	HYPH	denotes	-
T13853	20791-20792	CD	denotes	3
T13850	20793-20799	NN	denotes	source
T13854	20800-20802	IN	denotes	on
T13855	20803-20806	DT	denotes	the
T13857	20807-20813	NN	denotes	lesion
T13856	20814-20818	NN	denotes	side
T13858	20819-20821	IN	denotes	of
T13859	20822-20825	DT	denotes	the
T13861	20826-20832	JJ	denotes	spinal
T13860	20833-20837	NN	denotes	cord
T13862	20837-20838	.	denotes	.
T13863	20838-20988	sentence	denotes	Our present results are in agreement with these observations, and provide further evidence that NT-3 acts as a chemoattractant for sensory afferents.
T13864	20839-20842	PRP$	denotes	Our
T13866	20843-20850	JJ	denotes	present
T13865	20851-20858	NNS	denotes	results
T13867	20859-20862	VBP	denotes	are
T13868	20863-20865	IN	denotes	in
T13869	20866-20875	NN	denotes	agreement
T13870	20876-20880	IN	denotes	with
T13871	20881-20886	DT	denotes	these
T13872	20887-20899	NNS	denotes	observations
T13873	20899-20901	,	denotes	,
T13874	20901-20904	CC	denotes	and
T13875	20905-20912	VBP	denotes	provide
T13876	20913-20920	JJ	denotes	further
T13877	20921-20929	NN	denotes	evidence
T13878	20930-20934	IN	denotes	that
T13880	20935-20937	NN	denotes	NT
T13881	20937-20938	HYPH	denotes	-
T13882	20938-20939	CD	denotes	3
T13879	20940-20944	VBZ	denotes	acts
T13883	20945-20947	IN	denotes	as
T13884	20948-20949	DT	denotes	a
T13885	20950-20965	NN	denotes	chemoattractant
T13886	20966-20969	IN	denotes	for
T13887	20970-20977	JJ	denotes	sensory
T13888	20978-20987	NNS	denotes	afferents
T13889	20987-20988	.	denotes	.
T13890	20988-21138	sentence	denotes	Previously, normal motor neuron innervation was rescued in NT-3 KO animals by over-expressing NT-3 selectively in their muscles (Wright et al. 1997).
T13891	20989-20999	RB	denotes	Previously
T13893	20999-21001	,	denotes	,
T13894	21001-21007	JJ	denotes	normal
T13896	21008-21013	NN	denotes	motor
T13897	21014-21020	NN	denotes	neuron
T13895	21021-21032	NN	denotes	innervation
T13898	21033-21036	VBD	denotes	was
T13892	21037-21044	VBN	denotes	rescued
T13899	21045-21047	IN	denotes	in
T13900	21048-21050	NN	denotes	NT
T13902	21050-21051	HYPH	denotes	-
T13903	21051-21052	CD	denotes	3
T13901	21053-21055	NN	denotes	KO
T13904	21056-21063	NNS	denotes	animals
T13905	21064-21066	IN	denotes	by
T13906	21067-21082	VBG	denotes	over-expressing
T13907	21083-21085	NN	denotes	NT
T13908	21085-21086	HYPH	denotes	-
T13909	21086-21087	CD	denotes	3
T13910	21088-21099	RB	denotes	selectively
T13911	21100-21102	IN	denotes	in
T13912	21103-21108	PRP$	denotes	their
T13913	21109-21116	NNS	denotes	muscles
T13914	21117-21118	-LRB-	denotes	(
T13915	21118-21124	NNP	denotes	Wright
T13916	21125-21127	FW	denotes	et
T13917	21128-21131	FW	denotes	al.
T13918	21132-21136	CD	denotes	1997
T13919	21136-21137	-RRB-	denotes	)
T13920	21137-21138	.	denotes	.
T13921	21138-21295	sentence	denotes	It appears that peripheral NT-3 alone is sufficient for rescuing proprioceptive neurons in NT-3 KO animals and proper axonal pathfinding in the spinal cord.
T13922	21139-21141	PRP	denotes	It
T13923	21142-21149	VBZ	denotes	appears
T13924	21150-21154	IN	denotes	that
T13926	21155-21165	JJ	denotes	peripheral
T13927	21166-21168	NN	denotes	NT
T13928	21168-21169	HYPH	denotes	-
T13929	21169-21170	CD	denotes	3
T13930	21171-21176	RB	denotes	alone
T13925	21177-21179	VBZ	denotes	is
T13931	21180-21190	JJ	denotes	sufficient
T13932	21191-21194	IN	denotes	for
T13933	21195-21203	VBG	denotes	rescuing
T13934	21204-21218	JJ	denotes	proprioceptive
T13935	21219-21226	NNS	denotes	neurons
T13936	21227-21229	IN	denotes	in
T13937	21230-21232	NN	denotes	NT
T13939	21232-21233	HYPH	denotes	-
T13940	21233-21234	CD	denotes	3
T13938	21235-21237	NN	denotes	KO
T13941	21238-21245	NNS	denotes	animals
T13942	21246-21249	CC	denotes	and
T13943	21250-21256	JJ	denotes	proper
T13945	21257-21263	JJ	denotes	axonal
T13944	21264-21275	NN	denotes	pathfinding
T13946	21276-21278	IN	denotes	in
T13947	21279-21282	DT	denotes	the
T13949	21283-21289	JJ	denotes	spinal
T13948	21290-21294	NN	denotes	cord
T13950	21294-21295	.	denotes	.
T13951	21295-21389	sentence	denotes	However, it is unclear whether NT-3 is absent from the ventral spinal cords of these animals.
T13952	21296-21303	RB	denotes	However
T13954	21303-21305	,	denotes	,
T13955	21305-21307	PRP	denotes	it
T13953	21308-21310	VBZ	denotes	is
T13956	21311-21318	JJ	denotes	unclear
T13957	21319-21326	IN	denotes	whether
T13959	21327-21329	NN	denotes	NT
T13960	21329-21330	HYPH	denotes	-
T13961	21330-21331	CD	denotes	3
T13958	21332-21334	VBZ	denotes	is
T13962	21335-21341	JJ	denotes	absent
T13963	21342-21346	IN	denotes	from
T13964	21347-21350	DT	denotes	the
T13966	21351-21358	JJ	denotes	ventral
T13967	21359-21365	JJ	denotes	spinal
T13965	21366-21371	NNS	denotes	cords
T13968	21372-21374	IN	denotes	of
T13969	21375-21380	DT	denotes	these
T13970	21381-21388	NNS	denotes	animals
T13971	21388-21389	.	denotes	.
T13972	21389-21524	sentence	denotes	The possibility has been raised that motor neurons may retrogradely transport NT-3 in muscle to the spinal cord (Chen and Frank 1999).
T13973	21390-21393	DT	denotes	The
T13974	21394-21405	NN	denotes	possibility
T13976	21406-21409	VBZ	denotes	has
T13977	21410-21414	VBN	denotes	been
T13975	21415-21421	VBN	denotes	raised
T13978	21422-21426	IN	denotes	that
T13980	21427-21432	NN	denotes	motor
T13981	21433-21440	NNS	denotes	neurons
T13982	21441-21444	MD	denotes	may
T13983	21445-21457	RB	denotes	retrogradely
T13979	21458-21467	VB	denotes	transport
T13984	21468-21470	NN	denotes	NT
T13985	21470-21471	HYPH	denotes	-
T13986	21471-21472	CD	denotes	3
T13987	21473-21475	IN	denotes	in
T13988	21476-21482	NN	denotes	muscle
T13989	21483-21485	IN	denotes	to
T13990	21486-21489	DT	denotes	the
T13992	21490-21496	JJ	denotes	spinal
T13991	21497-21501	NN	denotes	cord
T13993	21502-21503	-LRB-	denotes	(
T13994	21503-21507	NNP	denotes	Chen
T13995	21508-21511	CC	denotes	and
T13996	21512-21517	NNP	denotes	Frank
T13997	21518-21522	CD	denotes	1999
T13998	21522-21523	-RRB-	denotes	)
T13999	21523-21524	.	denotes	.
T14000	21524-21629	sentence	denotes	Assays to determine whether any NT-3 is present in the ventral horns of these mice would be informative.
T14001	21525-21531	NNS	denotes	Assays
T14003	21532-21534	TO	denotes	to
T14004	21535-21544	VB	denotes	determine
T14005	21545-21552	IN	denotes	whether
T14007	21553-21556	DT	denotes	any
T14008	21557-21559	NN	denotes	NT
T14009	21559-21560	HYPH	denotes	-
T14010	21560-21561	CD	denotes	3
T14006	21562-21564	VBZ	denotes	is
T14011	21565-21572	JJ	denotes	present
T14012	21573-21575	IN	denotes	in
T14013	21576-21579	DT	denotes	the
T14015	21580-21587	JJ	denotes	ventral
T14014	21588-21593	NNS	denotes	horns
T14016	21594-21596	IN	denotes	of
T14017	21597-21602	DT	denotes	these
T14018	21603-21607	NNS	denotes	mice
T14019	21608-21613	MD	denotes	would
T14002	21614-21616	VB	denotes	be
T14020	21617-21628	JJ	denotes	informative
T14021	21628-21629	.	denotes	.
T14022	21629-21725	sentence	denotes	Recently, Patel et al. (2003) reported their observations on Bax/NT-3 double KO mice they bred.
T14023	21630-21638	RB	denotes	Recently
T14025	21638-21640	,	denotes	,
T14026	21640-21645	NNP	denotes	Patel
T14027	21646-21648	FW	denotes	et
T14028	21649-21652	FW	denotes	al.
T14029	21653-21654	-LRB-	denotes	(
T14030	21654-21658	CD	denotes	2003
T14031	21658-21659	-RRB-	denotes	)
T14024	21660-21668	VBD	denotes	reported
T14032	21669-21674	PRP$	denotes	their
T14033	21675-21687	NNS	denotes	observations
T14034	21688-21690	IN	denotes	on
T14035	21691-21694	NN	denotes	Bax
T14037	21694-21695	HYPH	denotes	/
T14038	21695-21697	NN	denotes	NT
T14039	21697-21698	HYPH	denotes	-
T14040	21698-21699	CD	denotes	3
T14041	21700-21706	JJ	denotes	double
T14036	21707-21709	NN	denotes	KO
T14042	21710-21714	NNS	denotes	mice
T14043	21715-21719	PRP	denotes	they
T14044	21720-21724	VBD	denotes	bred
T14045	21724-21725	.	denotes	.
T14046	21725-21778	sentence	denotes	Their results are significantly different from ours.
T14047	21726-21731	PRP$	denotes	Their
T14048	21732-21739	NNS	denotes	results
T14049	21740-21743	VBP	denotes	are
T14050	21744-21757	RB	denotes	significantly
T14051	21758-21767	JJ	denotes	different
T14052	21768-21772	IN	denotes	from
T14053	21773-21777	PRP	denotes	ours
T14054	21777-21778	.	denotes	.
T14055	21778-21974	sentence	denotes	They see no proprioceptive afferents in the periphery of the double knockouts and note that central proprioceptive afferents terminate in the intermediate spinal cord without extending ventrally.
T14056	21779-21783	PRP	denotes	They
T14057	21784-21787	VBP	denotes	see
T14058	21788-21790	DT	denotes	no
T14060	21791-21805	JJ	denotes	proprioceptive
T14059	21806-21815	NNS	denotes	afferents
T14061	21816-21818	IN	denotes	in
T14062	21819-21822	DT	denotes	the
T14063	21823-21832	NN	denotes	periphery
T14064	21833-21835	IN	denotes	of
T14065	21836-21839	DT	denotes	the
T14067	21840-21846	JJ	denotes	double
T14066	21847-21856	NNS	denotes	knockouts
T14068	21857-21860	CC	denotes	and
T14069	21861-21865	VBP	denotes	note
T14070	21866-21870	IN	denotes	that
T14072	21871-21878	JJ	denotes	central
T14074	21879-21893	JJ	denotes	proprioceptive
T14073	21894-21903	NNS	denotes	afferents
T14071	21904-21913	VBP	denotes	terminate
T14075	21914-21916	IN	denotes	in
T14076	21917-21920	DT	denotes	the
T14078	21921-21933	JJ	denotes	intermediate
T14079	21934-21940	JJ	denotes	spinal
T14077	21941-21945	NN	denotes	cord
T14080	21946-21953	IN	denotes	without
T14081	21954-21963	VBG	denotes	extending
T14082	21964-21973	RB	denotes	ventrally
T14083	21973-21974	.	denotes	.
T14084	21974-22067	sentence	denotes	Their observations are based on PV immunostaining and DiI labeling of the peripheral nerves.
T14085	21975-21980	PRP$	denotes	Their
T14086	21981-21993	NNS	denotes	observations
T14088	21994-21997	VBP	denotes	are
T14087	21998-22003	VBN	denotes	based
T14089	22004-22006	IN	denotes	on
T14090	22007-22009	NN	denotes	PV
T14091	22010-22024	NN	denotes	immunostaining
T14092	22025-22028	CC	denotes	and
T14093	22029-22032	NN	denotes	DiI
T14094	22033-22041	NN	denotes	labeling
T14095	22042-22044	IN	denotes	of
T14096	22045-22048	DT	denotes	the
T14098	22049-22059	JJ	denotes	peripheral
T14097	22060-22066	NNS	denotes	nerves
T14099	22066-22067	.	denotes	.
T14100	22067-22141	sentence	denotes	We noted that PV immunolabeling is diminished in our Bax/NT-3 double KOs.
T14101	22068-22070	PRP	denotes	We
T14102	22071-22076	VBD	denotes	noted
T14103	22077-22081	IN	denotes	that
T14105	22082-22084	NN	denotes	PV
T14106	22085-22099	NN	denotes	immunolabeling
T14104	22100-22102	VBZ	denotes	is
T14107	22103-22113	JJ	denotes	diminished
T14108	22114-22116	IN	denotes	in
T14109	22117-22120	PRP$	denotes	our
T14111	22121-22124	NN	denotes	Bax
T14112	22124-22125	HYPH	denotes	/
T14113	22125-22127	NN	denotes	NT
T14114	22127-22128	HYPH	denotes	-
T14115	22128-22129	CD	denotes	3
T14116	22130-22136	JJ	denotes	double
T14110	22137-22140	NNS	denotes	KOs
T14117	22140-22141	.	denotes	.
T14118	22141-22513	sentence	denotes	In various manipulations of the neurotrophins it has been noted that molecular markers for proprioceptive axons such as PV or calcitonin gene-related peptide for nerve growth factor–responsive axons are compromised (Ringstedt et al. 1997; Patel et al. 2000), thus PV immunostaining in Bax/NT-3 double KOs cannot reveal the extent of proprioceptive axons in the periphery.
T14119	22142-22144	IN	denotes	In
T14121	22145-22152	JJ	denotes	various
T14122	22153-22166	NNS	denotes	manipulations
T14123	22167-22169	IN	denotes	of
T14124	22170-22173	DT	denotes	the
T14125	22174-22187	NNS	denotes	neurotrophins
T14126	22188-22190	PRP	denotes	it
T14127	22191-22194	VBZ	denotes	has
T14128	22195-22199	VBN	denotes	been
T14120	22200-22205	VBN	denotes	noted
T14130	22206-22210	IN	denotes	that
T14132	22211-22220	JJ	denotes	molecular
T14133	22221-22228	NNS	denotes	markers
T14134	22229-22232	IN	denotes	for
T14135	22233-22247	JJ	denotes	proprioceptive
T14136	22248-22253	NNS	denotes	axons
T14137	22254-22258	JJ	denotes	such
T14138	22259-22261	IN	denotes	as
T14139	22262-22264	NN	denotes	PV
T14140	22265-22267	CC	denotes	or
T14141	22268-22278	NN	denotes	calcitonin
T14143	22279-22283	NN	denotes	gene
T14145	22283-22284	HYPH	denotes	-
T14144	22284-22291	VBN	denotes	related
T14142	22292-22299	NN	denotes	peptide
T14146	22300-22303	IN	denotes	for
T14147	22304-22309	NN	denotes	nerve
T14149	22310-22316	NN	denotes	growth
T14150	22317-22323	NN	denotes	factor
T14152	22323-22324	HYPH	denotes	–
T14151	22324-22334	JJ	denotes	responsive
T14148	22335-22340	NNS	denotes	axons
T14131	22341-22344	VBP	denotes	are
T14153	22345-22356	JJ	denotes	compromised
T14154	22357-22358	-LRB-	denotes	(
T14155	22358-22367	NNP	denotes	Ringstedt
T14156	22368-22370	FW	denotes	et
T14157	22371-22374	FW	denotes	al.
T14158	22375-22379	CD	denotes	1997
T14159	22379-22380	:	denotes	;
T14160	22381-22386	NNP	denotes	Patel
T14161	22387-22389	FW	denotes	et
T14162	22390-22393	FW	denotes	al.
T14163	22394-22398	CD	denotes	2000
T14164	22398-22399	-RRB-	denotes	)
T14165	22399-22401	,	denotes	,
T14166	22401-22405	RB	denotes	thus
T14167	22406-22408	NN	denotes	PV
T14168	22409-22423	NN	denotes	immunostaining
T14169	22424-22426	IN	denotes	in
T14170	22427-22430	NN	denotes	Bax
T14172	22430-22431	HYPH	denotes	/
T14173	22431-22433	NN	denotes	NT
T14174	22433-22434	HYPH	denotes	-
T14175	22434-22435	CD	denotes	3
T14176	22436-22442	JJ	denotes	double
T14171	22443-22446	NNS	denotes	KOs
T14177	22447-22450	MD	denotes	can
T14178	22450-22453	RB	denotes	not
T14129	22454-22460	VB	denotes	reveal
T14179	22461-22464	DT	denotes	the
T14180	22465-22471	NN	denotes	extent
T14181	22472-22474	IN	denotes	of
T14182	22475-22489	JJ	denotes	proprioceptive
T14183	22490-22495	NNS	denotes	axons
T14184	22496-22498	IN	denotes	in
T14185	22499-22502	DT	denotes	the
T14186	22503-22512	NN	denotes	periphery
T14187	22512-22513	.	denotes	.
T14188	22513-22746	sentence	denotes	Seventy-three percent of retrogradely labeled gastrocnemius muscle afferents were reported to be expressing TrkC RNA in the adult rat DRG, although some of these (about 10%) may represent cutaneous innervation (McMahon et al. 1994).
T14189	22514-22521	CD	denotes	Seventy
T14191	22521-22522	HYPH	denotes	-
T14190	22522-22527	CD	denotes	three
T14192	22528-22535	NN	denotes	percent
T14194	22536-22538	IN	denotes	of
T14195	22539-22551	RB	denotes	retrogradely
T14196	22552-22559	VBN	denotes	labeled
T14198	22560-22573	NN	denotes	gastrocnemius
T14199	22574-22580	NN	denotes	muscle
T14197	22581-22590	NNS	denotes	afferents
T14200	22591-22595	VBD	denotes	were
T14193	22596-22604	VBN	denotes	reported
T14201	22605-22607	TO	denotes	to
T14203	22608-22610	VB	denotes	be
T14202	22611-22621	VBG	denotes	expressing
T14204	22622-22626	NN	denotes	TrkC
T14205	22627-22630	NN	denotes	RNA
T14206	22631-22633	IN	denotes	in
T14207	22634-22637	DT	denotes	the
T14209	22638-22643	JJ	denotes	adult
T14210	22644-22647	NN	denotes	rat
T14208	22648-22651	NN	denotes	DRG
T14211	22651-22653	,	denotes	,
T14212	22653-22661	IN	denotes	although
T14214	22662-22666	DT	denotes	some
T14215	22667-22669	IN	denotes	of
T14216	22670-22675	DT	denotes	these
T14217	22676-22677	-LRB-	denotes	(
T14218	22677-22682	RB	denotes	about
T14219	22683-22685	CD	denotes	10
T14220	22685-22686	NN	denotes	%
T14221	22686-22687	-RRB-	denotes	)
T14222	22688-22691	MD	denotes	may
T14213	22692-22701	VB	denotes	represent
T14223	22702-22711	JJ	denotes	cutaneous
T14224	22712-22723	NN	denotes	innervation
T14225	22724-22725	-LRB-	denotes	(
T14226	22725-22732	NNP	denotes	McMahon
T14227	22733-22735	FW	denotes	et
T14228	22736-22739	FW	denotes	al.
T14229	22740-22744	CD	denotes	1994
T14230	22744-22745	-RRB-	denotes	)
T14231	22745-22746	.	denotes	.
T14232	22746-22916	sentence	denotes	Presently, it is not clear whether TrkC protein is also made by cutaneous afferents and if so at what stage in development this receptor is expressed by cutaneous axons.
T14233	22747-22756	RB	denotes	Presently
T14235	22756-22758	,	denotes	,
T14236	22758-22760	PRP	denotes	it
T14234	22761-22763	VBZ	denotes	is
T14237	22764-22767	RB	denotes	not
T14238	22768-22773	JJ	denotes	clear
T14239	22774-22781	IN	denotes	whether
T14241	22782-22786	NN	denotes	TrkC
T14242	22787-22794	NN	denotes	protein
T14243	22795-22797	VBZ	denotes	is
T14244	22798-22802	RB	denotes	also
T14240	22803-22807	VBN	denotes	made
T14245	22808-22810	IN	denotes	by
T14246	22811-22820	JJ	denotes	cutaneous
T14247	22821-22830	NNS	denotes	afferents
T14248	22831-22834	CC	denotes	and
T14249	22835-22837	IN	denotes	if
T14250	22838-22840	RB	denotes	so
T14252	22841-22843	IN	denotes	at
T14253	22844-22848	WDT	denotes	what
T14254	22849-22854	NN	denotes	stage
T14255	22855-22857	IN	denotes	in
T14256	22858-22869	NN	denotes	development
T14257	22870-22874	DT	denotes	this
T14258	22875-22883	NN	denotes	receptor
T14259	22884-22886	VBZ	denotes	is
T14251	22887-22896	VBN	denotes	expressed
T14260	22897-22899	IN	denotes	by
T14261	22900-22909	JJ	denotes	cutaneous
T14262	22910-22915	NNS	denotes	axons
T14263	22915-22916	.	denotes	.
T14264	22916-23161	sentence	denotes	Based on the available evidence showing that all proprioceptive neurons are eliminated in NT-3 or TrkC null mice, we think that TrkC staining in the tibial nerve mostly represents proprioceptive axons in the vicinity of their peripheral target.
T14265	22917-22922	VBN	denotes	Based
T14267	22923-22925	IN	denotes	on
T14268	22926-22929	DT	denotes	the
T14270	22930-22939	JJ	denotes	available
T14269	22940-22948	NN	denotes	evidence
T14271	22949-22956	VBG	denotes	showing
T14272	22957-22961	IN	denotes	that
T14274	22962-22965	DT	denotes	all
T14276	22966-22980	JJ	denotes	proprioceptive
T14275	22981-22988	NNS	denotes	neurons
T14277	22989-22992	VBP	denotes	are
T14273	22993-23003	VBN	denotes	eliminated
T14278	23004-23006	IN	denotes	in
T14279	23007-23009	NN	denotes	NT
T14281	23009-23010	HYPH	denotes	-
T14282	23010-23011	CD	denotes	3
T14283	23012-23014	CC	denotes	or
T14284	23015-23019	NN	denotes	TrkC
T14280	23020-23024	JJ	denotes	null
T14285	23025-23029	NNS	denotes	mice
T14286	23029-23031	,	denotes	,
T14287	23031-23033	PRP	denotes	we
T14266	23034-23039	VBP	denotes	think
T14288	23040-23044	IN	denotes	that
T14290	23045-23049	NN	denotes	TrkC
T14291	23050-23058	NN	denotes	staining
T14292	23059-23061	IN	denotes	in
T14293	23062-23065	DT	denotes	the
T14295	23066-23072	JJ	denotes	tibial
T14294	23073-23078	NN	denotes	nerve
T14296	23079-23085	RB	denotes	mostly
T14289	23086-23096	VBZ	denotes	represents
T14297	23097-23111	JJ	denotes	proprioceptive
T14298	23112-23117	NNS	denotes	axons
T14299	23118-23120	IN	denotes	in
T14300	23121-23124	DT	denotes	the
T14301	23125-23133	NN	denotes	vicinity
T14302	23134-23136	IN	denotes	of
T14303	23137-23142	PRP$	denotes	their
T14305	23143-23153	JJ	denotes	peripheral
T14304	23154-23160	NN	denotes	target
T14306	23160-23161	.	denotes	.
T14307	23161-23303	sentence	denotes	Altogether, our findings suggest a role for NT-3 in initiation of muscle innervation and spindle differentiation by the proprioceptive axons.
T14308	23162-23172	RB	denotes	Altogether
T14310	23172-23174	,	denotes	,
T14311	23174-23177	PRP$	denotes	our
T14312	23178-23186	NNS	denotes	findings
T14309	23187-23194	VBP	denotes	suggest
T14313	23195-23196	DT	denotes	a
T14314	23197-23201	NN	denotes	role
T14315	23202-23205	IN	denotes	for
T14316	23206-23208	NN	denotes	NT
T14317	23208-23209	HYPH	denotes	-
T14318	23209-23210	CD	denotes	3
T14319	23211-23213	IN	denotes	in
T14320	23214-23224	NN	denotes	initiation
T14321	23225-23227	IN	denotes	of
T14322	23228-23234	NN	denotes	muscle
T14323	23235-23246	NN	denotes	innervation
T14324	23247-23250	CC	denotes	and
T14325	23251-23258	NN	denotes	spindle
T14326	23259-23274	NN	denotes	differentiation
T14327	23275-23277	IN	denotes	by
T14328	23278-23281	DT	denotes	the
T14330	23282-23296	JJ	denotes	proprioceptive
T14329	23297-23302	NNS	denotes	axons
T14331	23302-23303	.	denotes	.
T14332	23303-23524	sentence	denotes	Patel et al. (2003) examined DiI-labeled central DRG axons in the spinal cord of three E17 and two P0 cases, and report that central proprioceptive axons stop in the intermediate laminae, never entering the ventral cord.
T14333	23304-23309	NNP	denotes	Patel
T14335	23310-23312	FW	denotes	et
T14336	23313-23316	FW	denotes	al.
T14337	23317-23318	-LRB-	denotes	(
T14338	23318-23322	CD	denotes	2003
T14339	23322-23323	-RRB-	denotes	)
T14334	23324-23332	VBN	denotes	examined
T14340	23333-23336	NN	denotes	DiI
T14342	23336-23337	HYPH	denotes	-
T14341	23337-23344	VBN	denotes	labeled
T14344	23345-23352	JJ	denotes	central
T14345	23353-23356	NN	denotes	DRG
T14343	23357-23362	NNS	denotes	axons
T14346	23363-23365	IN	denotes	in
T14347	23366-23369	DT	denotes	the
T14349	23370-23376	JJ	denotes	spinal
T14348	23377-23381	NN	denotes	cord
T14350	23382-23384	IN	denotes	of
T14351	23385-23390	CD	denotes	three
T14352	23391-23394	NN	denotes	E17
T14353	23395-23398	CC	denotes	and
T14354	23399-23402	CD	denotes	two
T14355	23403-23405	NN	denotes	P0
T14356	23406-23411	NNS	denotes	cases
T14357	23411-23413	,	denotes	,
T14358	23413-23416	CC	denotes	and
T14359	23417-23423	VBP	denotes	report
T14360	23424-23428	IN	denotes	that
T14362	23429-23436	JJ	denotes	central
T14364	23437-23451	JJ	denotes	proprioceptive
T14363	23452-23457	NNS	denotes	axons
T14361	23458-23462	VBP	denotes	stop
T14365	23463-23465	IN	denotes	in
T14366	23466-23469	DT	denotes	the
T14368	23470-23482	JJ	denotes	intermediate
T14367	23483-23490	NNS	denotes	laminae
T14369	23490-23492	,	denotes	,
T14370	23492-23497	RB	denotes	never
T14371	23498-23506	VBG	denotes	entering
T14372	23507-23510	DT	denotes	the
T14374	23511-23518	JJ	denotes	ventral
T14373	23519-23523	NN	denotes	cord
T14375	23523-23524	.	denotes	.
T14376	23524-23685	sentence	denotes	We have examined nine Bax/NT-3 double KO cases, and often incomplete DiI labeling gives the impression that there are no axons reaching the ventral spinal cord.
T14377	23525-23527	PRP	denotes	We
T14379	23528-23532	VBP	denotes	have
T14378	23533-23541	VBN	denotes	examined
T14380	23542-23546	CD	denotes	nine
T14382	23547-23550	NN	denotes	Bax
T14384	23550-23551	HYPH	denotes	/
T14385	23551-23553	NN	denotes	NT
T14386	23553-23554	HYPH	denotes	-
T14387	23554-23555	CD	denotes	3
T14388	23556-23562	JJ	denotes	double
T14383	23563-23565	NN	denotes	KO
T14381	23566-23571	NNS	denotes	cases
T14389	23571-23573	,	denotes	,
T14390	23573-23576	CC	denotes	and
T14391	23577-23582	RB	denotes	often
T14393	23583-23593	JJ	denotes	incomplete
T14395	23594-23597	NN	denotes	DiI
T14394	23598-23606	NN	denotes	labeling
T14392	23607-23612	VBZ	denotes	gives
T14396	23613-23616	DT	denotes	the
T14397	23617-23627	NN	denotes	impression
T14398	23628-23632	IN	denotes	that
T14400	23633-23638	EX	denotes	there
T14399	23639-23642	VBP	denotes	are
T14401	23643-23645	DT	denotes	no
T14402	23646-23651	NNS	denotes	axons
T14403	23652-23660	VBG	denotes	reaching
T14404	23661-23664	DT	denotes	the
T14406	23665-23672	JJ	denotes	ventral
T14407	23673-23679	JJ	denotes	spinal
T14405	23680-23684	NN	denotes	cord
T14408	23684-23685	.	denotes	.
T14409	23685-23839	sentence	denotes	We have also seen cases similar to theirs (n = 4), but at higher magnification these axons did not have terminal boutons and were not completely labeled.
T14410	23686-23688	PRP	denotes	We
T14412	23689-23693	VBP	denotes	have
T14413	23694-23698	RB	denotes	also
T14411	23699-23703	VBN	denotes	seen
T14414	23704-23709	NNS	denotes	cases
T14415	23710-23717	JJ	denotes	similar
T14416	23718-23720	IN	denotes	to
T14417	23721-23727	PRP	denotes	theirs
T14418	23728-23729	-LRB-	denotes	(
T14420	23729-23730	NN	denotes	n
T14421	23731-23732	SYM	denotes	=
T14419	23733-23734	CD	denotes	4
T14422	23734-23735	-RRB-	denotes	)
T14423	23735-23737	,	denotes	,
T14424	23737-23740	CC	denotes	but
T14425	23741-23743	IN	denotes	at
T14427	23744-23750	JJR	denotes	higher
T14428	23751-23764	NN	denotes	magnification
T14429	23765-23770	DT	denotes	these
T14430	23771-23776	NNS	denotes	axons
T14431	23777-23780	VBD	denotes	did
T14432	23781-23784	RB	denotes	not
T14426	23785-23789	VB	denotes	have
T14433	23790-23798	JJ	denotes	terminal
T14434	23799-23806	NNS	denotes	boutons
T14435	23807-23810	CC	denotes	and
T14436	23811-23815	VBD	denotes	were
T14438	23816-23819	RB	denotes	not
T14439	23820-23830	RB	denotes	completely
T14437	23831-23838	VBN	denotes	labeled
T14440	23838-23839	.	denotes	.
T14441	23839-24039	sentence	denotes	However, with complete fills (n = 5), it was possible to trace these axons into the ventral midline and across to the contralateral side, and visualize terminal boutons at their tips (see Figure 3C).
T14442	23840-23847	RB	denotes	However
T14444	23847-23849	,	denotes	,
T14445	23849-23853	IN	denotes	with
T14446	23854-23862	JJ	denotes	complete
T14447	23863-23868	NNS	denotes	fills
T14448	23869-23870	-LRB-	denotes	(
T14450	23870-23871	NN	denotes	n
T14451	23872-23873	SYM	denotes	=
T14449	23874-23875	CD	denotes	5
T14452	23875-23876	-RRB-	denotes	)
T14453	23876-23878	,	denotes	,
T14454	23878-23880	PRP	denotes	it
T14443	23881-23884	VBD	denotes	was
T14455	23885-23893	JJ	denotes	possible
T14456	23894-23896	TO	denotes	to
T14457	23897-23902	VB	denotes	trace
T14458	23903-23908	DT	denotes	these
T14459	23909-23914	NNS	denotes	axons
T14460	23915-23919	IN	denotes	into
T14461	23920-23923	DT	denotes	the
T14463	23924-23931	JJ	denotes	ventral
T14462	23932-23939	NN	denotes	midline
T14464	23940-23943	CC	denotes	and
T14465	23944-23950	IN	denotes	across
T14466	23951-23953	IN	denotes	to
T14467	23954-23957	DT	denotes	the
T14469	23958-23971	JJ	denotes	contralateral
T14468	23972-23976	NN	denotes	side
T14470	23976-23978	,	denotes	,
T14471	23978-23981	CC	denotes	and
T14472	23982-23991	VB	denotes	visualize
T14473	23992-24000	JJ	denotes	terminal
T14474	24001-24008	NNS	denotes	boutons
T14475	24009-24011	IN	denotes	at
T14476	24012-24017	PRP$	denotes	their
T14477	24018-24022	NNS	denotes	tips
T14478	24023-24024	-LRB-	denotes	(
T14479	24024-24027	VB	denotes	see
T14480	24028-24034	NN	denotes	Figure
T14481	24035-24037	NN	denotes	3C
T14482	24037-24038	-RRB-	denotes	)
T14483	24038-24039	.	denotes	.
T14484	24039-24238	sentence	denotes	Previously, Arber et al. (2000) reported that members of the Ets family of transcription factors, Er81 and Pea3, are expressed by DRG neurons as well as motor neurons and their target muscle fibers.
T14485	24040-24050	RB	denotes	Previously
T14487	24050-24052	,	denotes	,
T14488	24052-24057	NNP	denotes	Arber
T14489	24058-24060	FW	denotes	et
T14490	24061-24064	FW	denotes	al.
T14491	24065-24066	-LRB-	denotes	(
T14492	24066-24070	CD	denotes	2000
T14493	24070-24071	-RRB-	denotes	)
T14486	24072-24080	VBD	denotes	reported
T14494	24081-24085	IN	denotes	that
T14496	24086-24093	NNS	denotes	members
T14497	24094-24096	IN	denotes	of
T14498	24097-24100	DT	denotes	the
T14500	24101-24104	NN	denotes	Ets
T14499	24105-24111	NN	denotes	family
T14501	24112-24114	IN	denotes	of
T14502	24115-24128	NN	denotes	transcription
T14503	24129-24136	NNS	denotes	factors
T14504	24136-24138	,	denotes	,
T14505	24138-24142	NN	denotes	Er81
T14506	24143-24146	CC	denotes	and
T14507	24147-24151	NN	denotes	Pea3
T14508	24151-24153	,	denotes	,
T14509	24153-24156	VBP	denotes	are
T14495	24157-24166	VBN	denotes	expressed
T14510	24167-24169	IN	denotes	by
T14511	24170-24173	NN	denotes	DRG
T14512	24174-24181	NNS	denotes	neurons
T14513	24182-24184	RB	denotes	as
T14515	24185-24189	RB	denotes	well
T14514	24190-24192	IN	denotes	as
T14516	24193-24198	NN	denotes	motor
T14517	24199-24206	NNS	denotes	neurons
T14518	24207-24210	CC	denotes	and
T14519	24211-24216	PRP$	denotes	their
T14521	24217-24223	NN	denotes	target
T14522	24224-24230	NN	denotes	muscle
T14520	24231-24237	NNS	denotes	fibers
T14523	24237-24238	.	denotes	.
T14524	24238-24402	sentence	denotes	They found that in the spinal cord of Er81 KO mice, ventral projections of proprioceptive axons were mostly absent, and very few axons made it to the ventral cord.
T14525	24239-24243	PRP	denotes	They
T14526	24244-24249	VBD	denotes	found
T14527	24250-24254	IN	denotes	that
T14529	24255-24257	IN	denotes	in
T14530	24258-24261	DT	denotes	the
T14532	24262-24268	JJ	denotes	spinal
T14531	24269-24273	NN	denotes	cord
T14533	24274-24276	IN	denotes	of
T14534	24277-24281	NN	denotes	Er81
T14535	24282-24284	NN	denotes	KO
T14536	24285-24289	NNS	denotes	mice
T14537	24289-24291	,	denotes	,
T14538	24291-24298	JJ	denotes	ventral
T14539	24299-24310	NNS	denotes	projections
T14540	24311-24313	IN	denotes	of
T14541	24314-24328	JJ	denotes	proprioceptive
T14542	24329-24334	NNS	denotes	axons
T14528	24335-24339	VBD	denotes	were
T14543	24340-24346	RB	denotes	mostly
T14544	24347-24353	JJ	denotes	absent
T14545	24353-24355	,	denotes	,
T14546	24355-24358	CC	denotes	and
T14547	24359-24363	RB	denotes	very
T14549	24364-24367	JJ	denotes	few
T14548	24368-24373	NNS	denotes	axons
T14550	24374-24378	VBD	denotes	made
T14551	24379-24381	PRP	denotes	it
T14552	24382-24384	IN	denotes	to
T14553	24385-24388	DT	denotes	the
T14555	24389-24396	JJ	denotes	ventral
T14554	24397-24401	NN	denotes	cord
T14556	24401-24402	.	denotes	.
T14557	24402-24535	sentence	denotes	Patel et al. (2003) note that the phenotype they observed in their Bax/NT-3 double KO mice is quite similar to that of Er81 KO mice.
T14558	24403-24408	NNP	denotes	Patel
T14560	24409-24411	FW	denotes	et
T14561	24412-24415	FW	denotes	al.
T14562	24416-24417	-LRB-	denotes	(
T14563	24417-24421	CD	denotes	2003
T14564	24421-24422	-RRB-	denotes	)
T14559	24423-24427	VBP	denotes	note
T14565	24428-24432	IN	denotes	that
T14567	24433-24436	DT	denotes	the
T14568	24437-24446	NN	denotes	phenotype
T14569	24447-24451	PRP	denotes	they
T14570	24452-24460	VBD	denotes	observed
T14571	24461-24463	IN	denotes	in
T14572	24464-24469	PRP$	denotes	their
T14574	24470-24473	NN	denotes	Bax
T14576	24473-24474	HYPH	denotes	/
T14577	24474-24476	NN	denotes	NT
T14578	24476-24477	HYPH	denotes	-
T14579	24477-24478	CD	denotes	3
T14580	24479-24485	JJ	denotes	double
T14575	24486-24488	NN	denotes	KO
T14573	24489-24493	NNS	denotes	mice
T14566	24494-24496	VBZ	denotes	is
T14581	24497-24502	RB	denotes	quite
T14582	24503-24510	JJ	denotes	similar
T14583	24511-24513	IN	denotes	to
T14584	24514-24518	DT	denotes	that
T14585	24519-24521	IN	denotes	of
T14586	24522-24526	NN	denotes	Er81
T14587	24527-24529	NN	denotes	KO
T14588	24530-24534	NNS	denotes	mice
T14589	24534-24535	.	denotes	.
T14590	24535-24617	sentence	denotes	They provide evidence that NT-3 induces Er81 expression in DRG explants in vitro.
T14591	24536-24540	PRP	denotes	They
T14592	24541-24548	VBP	denotes	provide
T14593	24549-24557	NN	denotes	evidence
T14594	24558-24562	IN	denotes	that
T14596	24563-24565	NN	denotes	NT
T14597	24565-24566	HYPH	denotes	-
T14598	24566-24567	CD	denotes	3
T14595	24568-24575	VBZ	denotes	induces
T14599	24576-24580	NN	denotes	Er81
T14600	24581-24591	NN	denotes	expression
T14601	24592-24594	IN	denotes	in
T14602	24595-24598	NN	denotes	DRG
T14603	24599-24607	NNS	denotes	explants
T14604	24608-24610	FW	denotes	in
T14605	24611-24616	FW	denotes	vitro
T14606	24616-24617	.	denotes	.
T14607	24617-24840	sentence	denotes	Patel et al. (2003) report that Er81 mRNA expression is diminished (but not abolished) in both NT-3 KO and Bax/NT-3 double KO mice, while their immunohistochemistry shows much less protein expression in the double KO mice.
T14608	24618-24623	NNP	denotes	Patel
T14610	24624-24626	FW	denotes	et
T14611	24627-24630	FW	denotes	al.
T14612	24631-24632	-LRB-	denotes	(
T14613	24632-24636	CD	denotes	2003
T14614	24636-24637	-RRB-	denotes	)
T14609	24638-24644	VBP	denotes	report
T14615	24645-24649	IN	denotes	that
T14617	24650-24654	NN	denotes	Er81
T14619	24655-24659	NN	denotes	mRNA
T14618	24660-24670	NN	denotes	expression
T14620	24671-24673	VBZ	denotes	is
T14616	24674-24684	VBN	denotes	diminished
T14621	24685-24686	-LRB-	denotes	(
T14622	24686-24689	CC	denotes	but
T14623	24690-24693	RB	denotes	not
T14624	24694-24703	VBN	denotes	abolished
T14625	24703-24704	-RRB-	denotes	)
T14626	24705-24707	IN	denotes	in
T14627	24708-24712	CC	denotes	both
T14629	24713-24715	NN	denotes	NT
T14631	24715-24716	HYPH	denotes	-
T14632	24716-24717	CD	denotes	3
T14630	24718-24720	NN	denotes	KO
T14633	24721-24724	CC	denotes	and
T14634	24725-24728	NN	denotes	Bax
T14636	24728-24729	HYPH	denotes	/
T14637	24729-24731	NN	denotes	NT
T14638	24731-24732	HYPH	denotes	-
T14639	24732-24733	CD	denotes	3
T14640	24734-24740	JJ	denotes	double
T14635	24741-24743	NN	denotes	KO
T14628	24744-24748	NNS	denotes	mice
T14641	24748-24750	,	denotes	,
T14642	24750-24755	IN	denotes	while
T14644	24756-24761	PRP$	denotes	their
T14645	24762-24782	NN	denotes	immunohistochemistry
T14643	24783-24788	VBZ	denotes	shows
T14646	24789-24793	RB	denotes	much
T14647	24794-24798	JJR	denotes	less
T14649	24799-24806	NN	denotes	protein
T14648	24807-24817	NN	denotes	expression
T14650	24818-24820	IN	denotes	in
T14651	24821-24824	DT	denotes	the
T14653	24825-24831	JJ	denotes	double
T14654	24832-24834	NN	denotes	KO
T14652	24835-24839	NNS	denotes	mice
T14655	24839-24840	.	denotes	.
T14656	24840-25054	sentence	denotes	It is highly possible that a small but considerable number of DRG cells express the transcription factor Er81 and that their axons grow beyond the intermediate levels of the spinal cord in Bax/NT-3 double KO mice.
T14657	24841-24843	PRP	denotes	It
T14658	24844-24846	VBZ	denotes	is
T14659	24847-24853	RB	denotes	highly
T14660	24854-24862	JJ	denotes	possible
T14661	24863-24867	IN	denotes	that
T14663	24868-24869	DT	denotes	a
T14665	24870-24875	JJ	denotes	small
T14666	24876-24879	CC	denotes	but
T14667	24880-24892	JJ	denotes	considerable
T14664	24893-24899	NN	denotes	number
T14668	24900-24902	IN	denotes	of
T14669	24903-24906	NN	denotes	DRG
T14670	24907-24912	NNS	denotes	cells
T14662	24913-24920	VBP	denotes	express
T14671	24921-24924	DT	denotes	the
T14673	24925-24938	NN	denotes	transcription
T14672	24939-24945	NN	denotes	factor
T14674	24946-24950	NN	denotes	Er81
T14675	24951-24954	CC	denotes	and
T14676	24955-24959	IN	denotes	that
T14678	24960-24965	PRP$	denotes	their
T14679	24966-24971	NNS	denotes	axons
T14677	24972-24976	VB	denotes	grow
T14680	24977-24983	IN	denotes	beyond
T14681	24984-24987	DT	denotes	the
T14683	24988-25000	JJ	denotes	intermediate
T14682	25001-25007	NNS	denotes	levels
T14684	25008-25010	IN	denotes	of
T14685	25011-25014	DT	denotes	the
T14687	25015-25021	JJ	denotes	spinal
T14686	25022-25026	NN	denotes	cord
T14688	25027-25029	IN	denotes	in
T14689	25030-25033	NN	denotes	Bax
T14691	25033-25034	HYPH	denotes	/
T14692	25034-25036	NN	denotes	NT
T14693	25036-25037	HYPH	denotes	-
T14694	25037-25038	CD	denotes	3
T14695	25039-25045	JJ	denotes	double
T14690	25046-25048	NN	denotes	KO
T14696	25049-25053	NNS	denotes	mice
T14697	25053-25054	.	denotes	.
T14698	25054-25332	sentence	denotes	While the phenotype of Er81 KO mice is quite dramatic, and most proprioceptive axons stop within the intermediate spinal cord, it is important to note that a few axons still find their way to the ventral spinal cord and target properly to the motor neurons (Arber et al. 2000).
T14699	25055-25060	IN	denotes	While
T14701	25061-25064	DT	denotes	the
T14702	25065-25074	NN	denotes	phenotype
T14703	25075-25077	IN	denotes	of
T14704	25078-25082	NN	denotes	Er81
T14705	25083-25085	NN	denotes	KO
T14706	25086-25090	NNS	denotes	mice
T14700	25091-25093	VBZ	denotes	is
T14708	25094-25099	RB	denotes	quite
T14709	25100-25108	JJ	denotes	dramatic
T14710	25108-25110	,	denotes	,
T14711	25110-25113	CC	denotes	and
T14712	25114-25118	JJS	denotes	most
T14714	25119-25133	JJ	denotes	proprioceptive
T14713	25134-25139	NNS	denotes	axons
T14715	25140-25144	VB	denotes	stop
T14716	25145-25151	IN	denotes	within
T14717	25152-25155	DT	denotes	the
T14719	25156-25168	JJ	denotes	intermediate
T14720	25169-25175	JJ	denotes	spinal
T14718	25176-25180	NN	denotes	cord
T14721	25180-25182	,	denotes	,
T14722	25182-25184	PRP	denotes	it
T14707	25185-25187	VBZ	denotes	is
T14723	25188-25197	JJ	denotes	important
T14724	25198-25200	TO	denotes	to
T14725	25201-25205	VB	denotes	note
T14726	25206-25210	IN	denotes	that
T14728	25211-25212	DT	denotes	a
T14730	25213-25216	JJ	denotes	few
T14729	25217-25222	NNS	denotes	axons
T14731	25223-25228	RB	denotes	still
T14727	25229-25233	VBP	denotes	find
T14732	25234-25239	PRP$	denotes	their
T14733	25240-25243	NN	denotes	way
T14734	25244-25246	IN	denotes	to
T14735	25247-25250	DT	denotes	the
T14737	25251-25258	JJ	denotes	ventral
T14738	25259-25265	JJ	denotes	spinal
T14736	25266-25270	NN	denotes	cord
T14739	25271-25274	CC	denotes	and
T14740	25275-25281	VBP	denotes	target
T14741	25282-25290	RB	denotes	properly
T14742	25291-25293	IN	denotes	to
T14743	25294-25297	DT	denotes	the
T14745	25298-25303	NN	denotes	motor
T14744	25304-25311	NNS	denotes	neurons
T14746	25312-25313	-LRB-	denotes	(
T14747	25313-25318	NNP	denotes	Arber
T14748	25319-25321	FW	denotes	et
T14749	25322-25325	FW	denotes	al.
T14750	25326-25330	CD	denotes	2000
T14751	25330-25331	-RRB-	denotes	)
T14752	25331-25332	.	denotes	.
T14753	25332-25474	sentence	denotes	Patel et al. (2003) also present observations from islet2DTA mice, which lack a significant portion of the motor neurons in the ventral cord.
T14754	25333-25338	NNP	denotes	Patel
T14756	25339-25341	FW	denotes	et
T14757	25342-25345	FW	denotes	al.
T14758	25346-25347	-LRB-	denotes	(
T14759	25347-25351	CD	denotes	2003
T14760	25351-25352	-RRB-	denotes	)
T14761	25353-25357	RB	denotes	also
T14755	25358-25365	VBP	denotes	present
T14762	25366-25378	NNS	denotes	observations
T14763	25379-25383	IN	denotes	from
T14764	25384-25393	NN	denotes	islet2DTA
T14765	25394-25398	NNS	denotes	mice
T14766	25398-25400	,	denotes	,
T14767	25400-25405	WDT	denotes	which
T14768	25406-25410	VBP	denotes	lack
T14769	25411-25412	DT	denotes	a
T14771	25413-25424	JJ	denotes	significant
T14770	25425-25432	NN	denotes	portion
T14772	25433-25435	IN	denotes	of
T14773	25436-25439	DT	denotes	the
T14775	25440-25445	NN	denotes	motor
T14774	25446-25453	NNS	denotes	neurons
T14776	25454-25456	IN	denotes	in
T14777	25457-25460	DT	denotes	the
T14779	25461-25468	JJ	denotes	ventral
T14778	25469-25473	NN	denotes	cord
T14780	25473-25474	.	denotes	.
T14781	25474-25540	sentence	denotes	In these mice PV immunostaining shows axons in the ventral horns.
T14782	25475-25477	IN	denotes	In
T14784	25478-25483	DT	denotes	these
T14785	25484-25488	NNS	denotes	mice
T14786	25489-25491	NN	denotes	PV
T14787	25492-25506	NN	denotes	immunostaining
T14783	25507-25512	VBZ	denotes	shows
T14788	25513-25518	NNS	denotes	axons
T14789	25519-25521	IN	denotes	in
T14790	25522-25525	DT	denotes	the
T14792	25526-25533	JJ	denotes	ventral
T14791	25534-25539	NNS	denotes	horns
T14793	25539-25540	.	denotes	.
T14794	25540-25715	sentence	denotes	Patel et al. argue that since motor neurons are absent in these mice, NT-3 secreted by them could not be a signal for proprioceptive axons to enter the lateral motor columns.
T14795	25541-25546	NNP	denotes	Patel
T14797	25547-25549	FW	denotes	et
T14798	25550-25553	FW	denotes	al.
T14796	25554-25559	VBP	denotes	argue
T14799	25560-25564	IN	denotes	that
T14801	25565-25570	IN	denotes	since
T14803	25571-25576	NN	denotes	motor
T14804	25577-25584	NNS	denotes	neurons
T14802	25585-25588	VBP	denotes	are
T14805	25589-25595	JJ	denotes	absent
T14806	25596-25598	IN	denotes	in
T14807	25599-25604	DT	denotes	these
T14808	25605-25609	NNS	denotes	mice
T14809	25609-25611	,	denotes	,
T14810	25611-25613	NN	denotes	NT
T14811	25613-25614	HYPH	denotes	-
T14812	25614-25615	CD	denotes	3
T14813	25616-25624	VBN	denotes	secreted
T14814	25625-25627	IN	denotes	by
T14815	25628-25632	PRP	denotes	them
T14816	25633-25638	MD	denotes	could
T14817	25639-25642	RB	denotes	not
T14800	25643-25645	VB	denotes	be
T14818	25646-25647	DT	denotes	a
T14819	25648-25654	NN	denotes	signal
T14820	25655-25658	IN	denotes	for
T14822	25659-25673	JJ	denotes	proprioceptive
T14823	25674-25679	NNS	denotes	axons
T14824	25680-25682	TO	denotes	to
T14821	25683-25688	VB	denotes	enter
T14825	25689-25692	DT	denotes	the
T14827	25693-25700	JJ	denotes	lateral
T14828	25701-25706	NN	denotes	motor
T14826	25707-25714	NNS	denotes	columns
T14829	25714-25715	.	denotes	.
T14830	25715-26011	sentence	denotes	However, there is no evidence showing that NT-3 mRNA or protein expressed in the ventral spinal cord is exclusively from motor neurons, and there are no available data indicating that in islet2DTA mice, NT-3 expression in the ventral spinal cord is abolished (Yang et al. 2001; Pun et al. 2002).
T14831	25716-25723	RB	denotes	However
T14833	25723-25725	,	denotes	,
T14834	25725-25730	EX	denotes	there
T14832	25731-25733	VBZ	denotes	is
T14835	25734-25736	DT	denotes	no
T14836	25737-25745	NN	denotes	evidence
T14837	25746-25753	VBG	denotes	showing
T14838	25754-25758	IN	denotes	that
T14840	25759-25761	NN	denotes	NT
T14842	25761-25762	HYPH	denotes	-
T14843	25762-25763	CD	denotes	3
T14841	25764-25768	NN	denotes	mRNA
T14844	25769-25771	CC	denotes	or
T14845	25772-25779	NN	denotes	protein
T14846	25780-25789	VBN	denotes	expressed
T14847	25790-25792	IN	denotes	in
T14848	25793-25796	DT	denotes	the
T14850	25797-25804	JJ	denotes	ventral
T14851	25805-25811	JJ	denotes	spinal
T14849	25812-25816	NN	denotes	cord
T14839	25817-25819	VBZ	denotes	is
T14852	25820-25831	RB	denotes	exclusively
T14853	25832-25836	IN	denotes	from
T14854	25837-25842	NN	denotes	motor
T14855	25843-25850	NNS	denotes	neurons
T14856	25850-25852	,	denotes	,
T14857	25852-25855	CC	denotes	and
T14858	25856-25861	EX	denotes	there
T14859	25862-25865	VBP	denotes	are
T14860	25866-25868	DT	denotes	no
T14862	25869-25878	JJ	denotes	available
T14861	25879-25883	NNS	denotes	data
T14863	25884-25894	VBG	denotes	indicating
T14864	25895-25899	IN	denotes	that
T14866	25900-25902	IN	denotes	in
T14867	25903-25912	NN	denotes	islet2DTA
T14868	25913-25917	NNS	denotes	mice
T14869	25917-25919	,	denotes	,
T14870	25919-25921	NN	denotes	NT
T14872	25921-25922	HYPH	denotes	-
T14873	25922-25923	CD	denotes	3
T14871	25924-25934	NN	denotes	expression
T14874	25935-25937	IN	denotes	in
T14875	25938-25941	DT	denotes	the
T14877	25942-25949	JJ	denotes	ventral
T14878	25950-25956	JJ	denotes	spinal
T14876	25957-25961	NN	denotes	cord
T14879	25962-25964	VBZ	denotes	is
T14865	25965-25974	VBN	denotes	abolished
T14880	25975-25976	-LRB-	denotes	(
T14881	25976-25980	NNP	denotes	Yang
T14882	25981-25983	FW	denotes	et
T14883	25984-25987	FW	denotes	al.
T14884	25988-25992	CD	denotes	2001
T14885	25992-25993	:	denotes	;
T14886	25994-25997	NNP	denotes	Pun
T14887	25998-26000	FW	denotes	et
T14888	26001-26004	FW	denotes	al.
T14889	26005-26009	CD	denotes	2002
T14890	26009-26010	-RRB-	denotes	)
T14891	26010-26011	.	denotes	.
T14892	26011-26188	sentence	denotes	Studies in embryonic mice reported NT-3 mRNA in the ventral horns of the spinal cord, but it is not definitive that both mRNA and protein are expressed solely by motor neurons.
T14893	26012-26019	NNS	denotes	Studies
T14895	26020-26022	IN	denotes	in
T14896	26023-26032	JJ	denotes	embryonic
T14897	26033-26037	NNS	denotes	mice
T14894	26038-26046	VBD	denotes	reported
T14898	26047-26049	NN	denotes	NT
T14900	26049-26050	HYPH	denotes	-
T14901	26050-26051	CD	denotes	3
T14899	26052-26056	NN	denotes	mRNA
T14902	26057-26059	IN	denotes	in
T14903	26060-26063	DT	denotes	the
T14905	26064-26071	JJ	denotes	ventral
T14904	26072-26077	NNS	denotes	horns
T14906	26078-26080	IN	denotes	of
T14907	26081-26084	DT	denotes	the
T14909	26085-26091	JJ	denotes	spinal
T14908	26092-26096	NN	denotes	cord
T14910	26096-26098	,	denotes	,
T14911	26098-26101	CC	denotes	but
T14912	26102-26104	PRP	denotes	it
T14913	26105-26107	VBZ	denotes	is
T14914	26108-26111	RB	denotes	not
T14915	26112-26122	JJ	denotes	definitive
T14916	26123-26127	IN	denotes	that
T14918	26128-26132	CC	denotes	both
T14919	26133-26137	NN	denotes	mRNA
T14920	26138-26141	CC	denotes	and
T14921	26142-26149	NN	denotes	protein
T14922	26150-26153	VBP	denotes	are
T14917	26154-26163	VBN	denotes	expressed
T14923	26164-26170	RB	denotes	solely
T14924	26171-26173	IN	denotes	by
T14925	26174-26179	NN	denotes	motor
T14926	26180-26187	NNS	denotes	neurons
T14927	26187-26188	.	denotes	.
T14928	26188-26369	sentence	denotes	In the adult spinal cord, while motor neurons express high levels of NT-3, other cells, including glia, also express it (Zhou and Rush 1994; Dreyfus et al. 1999; Buck et al. 2000).
T14929	26189-26191	IN	denotes	In
T14931	26192-26195	DT	denotes	the
T14933	26196-26201	JJ	denotes	adult
T14934	26202-26208	JJ	denotes	spinal
T14932	26209-26213	NN	denotes	cord
T14935	26213-26215	,	denotes	,
T14936	26215-26220	IN	denotes	while
T14938	26221-26226	NN	denotes	motor
T14939	26227-26234	NNS	denotes	neurons
T14937	26235-26242	VBP	denotes	express
T14940	26243-26247	JJ	denotes	high
T14941	26248-26254	NNS	denotes	levels
T14942	26255-26257	IN	denotes	of
T14943	26258-26260	NN	denotes	NT
T14944	26260-26261	HYPH	denotes	-
T14945	26261-26262	CD	denotes	3
T14946	26262-26264	,	denotes	,
T14947	26264-26269	JJ	denotes	other
T14948	26270-26275	NNS	denotes	cells
T14949	26275-26277	,	denotes	,
T14950	26277-26286	VBG	denotes	including
T14951	26287-26291	NN	denotes	glia
T14952	26291-26293	,	denotes	,
T14953	26293-26297	RB	denotes	also
T14930	26298-26305	VBP	denotes	express
T14954	26306-26308	PRP	denotes	it
T14955	26309-26310	-LRB-	denotes	(
T14956	26310-26314	NNP	denotes	Zhou
T14957	26315-26318	CC	denotes	and
T14958	26319-26323	NNP	denotes	Rush
T14959	26324-26328	CD	denotes	1994
T14960	26328-26329	:	denotes	;
T14961	26330-26337	NNP	denotes	Dreyfus
T14962	26338-26340	FW	denotes	et
T14963	26341-26344	FW	denotes	al.
T14964	26345-26349	CD	denotes	1999
T14965	26349-26350	:	denotes	;
T14966	26351-26355	NNP	denotes	Buck
T14967	26356-26358	FW	denotes	et
T14968	26359-26362	FW	denotes	al.
T14969	26363-26367	CD	denotes	2000
T14970	26367-26368	-RRB-	denotes	)
T14971	26368-26369	.	denotes	.
T14972	26369-26619	sentence	denotes	Our present results, along with those from transgenic mice with NT-3 over-expression in ectopic regions of the spinal cord (Ringstedt et al. 1997), argue for a role of NT-3 in chemoattractant axon guidance of proprioceptive axons in the spinal cord.
T14973	26370-26373	PRP$	denotes	Our
T14975	26374-26381	JJ	denotes	present
T14974	26382-26389	NNS	denotes	results
T14977	26389-26391	,	denotes	,
T14978	26391-26396	IN	denotes	along
T14979	26397-26401	IN	denotes	with
T14980	26402-26407	DT	denotes	those
T14981	26408-26412	IN	denotes	from
T14982	26413-26423	JJ	denotes	transgenic
T14983	26424-26428	NNS	denotes	mice
T14984	26429-26433	IN	denotes	with
T14985	26434-26436	NN	denotes	NT
T14987	26436-26437	HYPH	denotes	-
T14988	26437-26438	CD	denotes	3
T14986	26439-26454	NN	denotes	over-expression
T14989	26455-26457	IN	denotes	in
T14990	26458-26465	JJ	denotes	ectopic
T14991	26466-26473	NNS	denotes	regions
T14992	26474-26476	IN	denotes	of
T14993	26477-26480	DT	denotes	the
T14995	26481-26487	JJ	denotes	spinal
T14994	26488-26492	NN	denotes	cord
T14996	26493-26494	-LRB-	denotes	(
T14997	26494-26503	NNP	denotes	Ringstedt
T14998	26504-26506	FW	denotes	et
T14999	26507-26510	FW	denotes	al.
T15000	26511-26515	CD	denotes	1997
T15001	26515-26516	-RRB-	denotes	)
T15002	26516-26518	,	denotes	,
T14976	26518-26523	VBP	denotes	argue
T15003	26524-26527	IN	denotes	for
T15004	26528-26529	DT	denotes	a
T15005	26530-26534	NN	denotes	role
T15006	26535-26537	IN	denotes	of
T15007	26538-26540	NN	denotes	NT
T15008	26540-26541	HYPH	denotes	-
T15009	26541-26542	CD	denotes	3
T15010	26543-26545	IN	denotes	in
T15011	26546-26561	NN	denotes	chemoattractant
T15013	26562-26566	NN	denotes	axon
T15012	26567-26575	NN	denotes	guidance
T15014	26576-26578	IN	denotes	of
T15015	26579-26593	JJ	denotes	proprioceptive
T15016	26594-26599	NNS	denotes	axons
T15017	26600-26602	IN	denotes	in
T15018	26603-26606	DT	denotes	the
T15020	26607-26613	JJ	denotes	spinal
T15019	26614-26618	NN	denotes	cord
T15021	26618-26619	.	denotes	.
T15022	26619-26724	sentence	denotes	Finally, in culture assays, we see a strong chemoattraction of DRG neurons to localized sources of NT-3.
T15023	26620-26627	RB	denotes	Finally
T15025	26627-26629	,	denotes	,
T15026	26629-26631	IN	denotes	in
T15027	26632-26639	NN	denotes	culture
T15028	26640-26646	NNS	denotes	assays
T15029	26646-26648	,	denotes	,
T15030	26648-26650	PRP	denotes	we
T15024	26651-26654	VBP	denotes	see
T15031	26655-26656	DT	denotes	a
T15033	26657-26663	JJ	denotes	strong
T15032	26664-26679	NN	denotes	chemoattraction
T15034	26680-26682	IN	denotes	of
T15035	26683-26686	NN	denotes	DRG
T15036	26687-26694	NNS	denotes	neurons
T15037	26695-26697	IN	denotes	to
T15038	26698-26707	JJ	denotes	localized
T15039	26708-26715	NNS	denotes	sources
T15040	26716-26718	IN	denotes	of
T15041	26719-26721	NN	denotes	NT
T15042	26721-26722	HYPH	denotes	-
T15043	26722-26723	CD	denotes	3
T15044	26723-26724	.	denotes	.
T15045	26724-26881	sentence	denotes	This response is seen in WT, Bax null and in p75 null DRG explants, and in the absence of any other neurotrophins or target-derived axon guidance molecules.
T15046	26725-26729	DT	denotes	This
T15047	26730-26738	NN	denotes	response
T15049	26739-26741	VBZ	denotes	is
T15048	26742-26746	VBN	denotes	seen
T15050	26747-26749	IN	denotes	in
T15051	26750-26752	NN	denotes	WT
T15053	26752-26754	,	denotes	,
T15052	26754-26757	NN	denotes	Bax
T15054	26758-26762	JJ	denotes	null
T15055	26763-26766	CC	denotes	and
T15056	26767-26769	IN	denotes	in
T15057	26770-26773	NN	denotes	p75
T15058	26774-26778	JJ	denotes	null
T15059	26779-26782	NN	denotes	DRG
T15060	26783-26791	NNS	denotes	explants
T15061	26791-26793	,	denotes	,
T15062	26793-26796	CC	denotes	and
T15063	26797-26799	IN	denotes	in
T15064	26800-26803	DT	denotes	the
T15065	26804-26811	NN	denotes	absence
T15066	26812-26814	IN	denotes	of
T15067	26815-26818	DT	denotes	any
T15069	26819-26824	JJ	denotes	other
T15068	26825-26838	NNS	denotes	neurotrophins
T15070	26839-26841	CC	denotes	or
T15071	26842-26848	NN	denotes	target
T15073	26848-26849	HYPH	denotes	-
T15072	26849-26856	VBN	denotes	derived
T15075	26857-26861	NN	denotes	axon
T15076	26862-26870	NN	denotes	guidance
T15074	26871-26880	NNS	denotes	molecules
T15077	26880-26881	.	denotes	.
T15078	26881-27016	sentence	denotes	Furthermore, in vitro, sensory axon response to NT-3 does not appear to be dose-dependent (Ringstedt et al. 1997; Tucker et al. 2001).
T15079	26882-26893	RB	denotes	Furthermore
T15081	26893-26895	,	denotes	,
T15082	26895-26897	FW	denotes	in
T15083	26898-26903	FW	denotes	vitro
T15084	26903-26905	,	denotes	,
T15085	26905-26912	JJ	denotes	sensory
T15086	26913-26917	NN	denotes	axon
T15087	26918-26926	NN	denotes	response
T15088	26927-26929	IN	denotes	to
T15089	26930-26932	NN	denotes	NT
T15090	26932-26933	HYPH	denotes	-
T15091	26933-26934	CD	denotes	3
T15092	26935-26939	VBZ	denotes	does
T15093	26940-26943	RB	denotes	not
T15080	26944-26950	VB	denotes	appear
T15094	26951-26953	TO	denotes	to
T15095	26954-26956	VB	denotes	be
T15096	26957-26961	NN	denotes	dose
T15098	26961-26962	HYPH	denotes	-
T15097	26962-26971	JJ	denotes	dependent
T15099	26972-26973	-LRB-	denotes	(
T15100	26973-26982	NNP	denotes	Ringstedt
T15101	26983-26985	FW	denotes	et
T15102	26986-26989	FW	denotes	al.
T15103	26990-26994	CD	denotes	1997
T15104	26994-26995	:	denotes	;
T15105	26996-27002	NNP	denotes	Tucker
T15106	27003-27005	FW	denotes	et
T15107	27006-27009	FW	denotes	al.
T15108	27010-27014	CD	denotes	2001
T15109	27014-27015	-RRB-	denotes	)
T15110	27015-27016	.	denotes	.
T15111	27016-27185	sentence	denotes	NT-3 is capable of attracting axons along distances of up to 1 mm in collagen gel matrix, covering the physiological range it needs to attract axons during development.
T15112	27017-27019	NN	denotes	NT
T15114	27019-27020	HYPH	denotes	-
T15115	27020-27021	CD	denotes	3
T15113	27022-27024	VBZ	denotes	is
T15116	27025-27032	JJ	denotes	capable
T15117	27033-27035	IN	denotes	of
T15118	27036-27046	VBG	denotes	attracting
T15119	27047-27052	NNS	denotes	axons
T15120	27053-27058	IN	denotes	along
T15121	27059-27068	NNS	denotes	distances
T15122	27069-27071	IN	denotes	of
T15123	27072-27074	IN	denotes	up
T15125	27075-27077	IN	denotes	to
T15124	27078-27079	CD	denotes	1
T15126	27080-27082	NN	denotes	mm
T15127	27083-27085	IN	denotes	in
T15128	27086-27094	NN	denotes	collagen
T15130	27095-27098	NN	denotes	gel
T15129	27099-27105	NN	denotes	matrix
T15131	27105-27107	,	denotes	,
T15132	27107-27115	VBG	denotes	covering
T15133	27116-27119	DT	denotes	the
T15135	27120-27133	JJ	denotes	physiological
T15134	27134-27139	NN	denotes	range
T15136	27140-27142	PRP	denotes	it
T15137	27143-27148	VBZ	denotes	needs
T15138	27149-27151	TO	denotes	to
T15139	27152-27159	VB	denotes	attract
T15140	27160-27165	NNS	denotes	axons
T15141	27166-27172	IN	denotes	during
T15142	27173-27184	NN	denotes	development
T15143	27184-27185	.	denotes	.
T15144	27185-27436	sentence	denotes	Previous studies with exogenous or local applications of NT-3 to developing primary sensory axons have indicated that this neurotrophin can attract and induce axonal branching (Ulupınar et al. 2000; Özdinler and Erzurumlu 2001, Özdinler et al. 2004).
T15145	27186-27194	JJ	denotes	Previous
T15146	27195-27202	NNS	denotes	studies
T15148	27203-27207	IN	denotes	with
T15149	27208-27217	JJ	denotes	exogenous
T15151	27218-27220	CC	denotes	or
T15152	27221-27226	JJ	denotes	local
T15150	27227-27239	NNS	denotes	applications
T15153	27240-27242	IN	denotes	of
T15154	27243-27245	NN	denotes	NT
T15155	27245-27246	HYPH	denotes	-
T15156	27246-27247	CD	denotes	3
T15157	27248-27250	IN	denotes	to
T15158	27251-27261	JJ	denotes	developing
T15160	27262-27269	JJ	denotes	primary
T15161	27270-27277	JJ	denotes	sensory
T15159	27278-27283	NNS	denotes	axons
T15162	27284-27288	VBP	denotes	have
T15147	27289-27298	VBN	denotes	indicated
T15163	27299-27303	IN	denotes	that
T15165	27304-27308	DT	denotes	this
T15166	27309-27321	NN	denotes	neurotrophin
T15167	27322-27325	MD	denotes	can
T15164	27326-27333	VB	denotes	attract
T15168	27334-27337	CC	denotes	and
T15169	27338-27344	VB	denotes	induce
T15170	27345-27351	JJ	denotes	axonal
T15171	27352-27361	NN	denotes	branching
T15172	27362-27363	-LRB-	denotes	(
T15173	27363-27371	NNP	denotes	Ulupınar
T15174	27372-27374	FW	denotes	et
T15175	27375-27378	FW	denotes	al.
T15176	27379-27383	CD	denotes	2000
T15177	27383-27384	:	denotes	;
T15178	27385-27393	NNP	denotes	Özdinler
T15179	27394-27397	CC	denotes	and
T15180	27398-27407	NNP	denotes	Erzurumlu
T15181	27408-27412	CD	denotes	2001
T15182	27412-27414	,	denotes	,
T15183	27414-27422	NNP	denotes	Özdinler
T15184	27423-27425	FW	denotes	et
T15185	27426-27429	FW	denotes	al.
T15186	27430-27434	CD	denotes	2004
T15187	27434-27435	-RRB-	denotes	)
T15188	27435-27436	.	denotes	.
T15189	27436-27587	sentence	denotes	Along the monosynaptic stretch reflex pathway, only Wnt-3 has been implicated as an axon arborization factor in the spinal cord (Krylova et al. 2002).
T15190	27437-27442	IN	denotes	Along
T15192	27443-27446	DT	denotes	the
T15194	27447-27459	JJ	denotes	monosynaptic
T15195	27460-27467	NN	denotes	stretch
T15196	27468-27474	NN	denotes	reflex
T15193	27475-27482	NN	denotes	pathway
T15197	27482-27484	,	denotes	,
T15198	27484-27488	RB	denotes	only
T15199	27489-27492	NN	denotes	Wnt
T15200	27492-27493	HYPH	denotes	-
T15201	27493-27494	CD	denotes	3
T15202	27495-27498	VBZ	denotes	has
T15203	27499-27503	VBN	denotes	been
T15191	27504-27514	VBN	denotes	implicated
T15204	27515-27517	IN	denotes	as
T15205	27518-27520	DT	denotes	an
T15207	27521-27525	NN	denotes	axon
T15208	27526-27538	NN	denotes	arborization
T15206	27539-27545	NN	denotes	factor
T15209	27546-27548	IN	denotes	in
T15210	27549-27552	DT	denotes	the
T15212	27553-27559	JJ	denotes	spinal
T15211	27560-27564	NN	denotes	cord
T15213	27565-27566	-LRB-	denotes	(
T15214	27566-27573	NNP	denotes	Krylova
T15215	27574-27576	FW	denotes	et
T15216	27577-27580	FW	denotes	al.
T15217	27581-27585	CD	denotes	2002
T15218	27585-27586	-RRB-	denotes	)
T15219	27586-27587	.	denotes	.
T15220	27587-27779	sentence	denotes	Another molecule, Slit2, expressed in the midline and by motor neurons (Wang et al. 1999) is capable of inducing axonal branching (Nguyen Ba-Charvet et al. 2001; Özdinler and Erzurumlu 2002).
T15221	27588-27595	DT	denotes	Another
T15222	27596-27604	NN	denotes	molecule
T15224	27604-27606	,	denotes	,
T15225	27606-27611	NN	denotes	Slit2
T15226	27611-27613	,	denotes	,
T15227	27613-27622	VBN	denotes	expressed
T15228	27623-27625	IN	denotes	in
T15229	27626-27629	DT	denotes	the
T15230	27630-27637	NN	denotes	midline
T15231	27638-27641	CC	denotes	and
T15232	27642-27644	IN	denotes	by
T15233	27645-27650	NN	denotes	motor
T15234	27651-27658	NNS	denotes	neurons
T15235	27659-27660	-LRB-	denotes	(
T15236	27660-27664	NNP	denotes	Wang
T15237	27665-27667	FW	denotes	et
T15238	27668-27671	FW	denotes	al.
T15239	27672-27676	CD	denotes	1999
T15240	27676-27677	-RRB-	denotes	)
T15223	27678-27680	VBZ	denotes	is
T15241	27681-27688	JJ	denotes	capable
T15242	27689-27691	IN	denotes	of
T15243	27692-27700	VBG	denotes	inducing
T15244	27701-27707	JJ	denotes	axonal
T15245	27708-27717	NN	denotes	branching
T15246	27718-27719	-LRB-	denotes	(
T15247	27719-27725	NNP	denotes	Nguyen
T15248	27726-27728	NNP	denotes	Ba
T15249	27728-27729	HYPH	denotes	-
T15250	27729-27736	NNP	denotes	Charvet
T15251	27737-27739	FW	denotes	et
T15252	27740-27743	FW	denotes	al.
T15253	27744-27748	CD	denotes	2001
T15254	27748-27749	:	denotes	;
T15255	27750-27758	NNP	denotes	Özdinler
T15256	27759-27762	CC	denotes	and
T15257	27763-27772	NNP	denotes	Erzurumlu
T15258	27773-27777	CD	denotes	2002
T15259	27777-27778	-RRB-	denotes	)
T15260	27778-27779	.	denotes	.
T15261	27779-27933	sentence	denotes	DRG neurons express Robo receptors, which bind to Slits, and proprioceptive axons are therefore capable of responding to Slit signals (Wang et al. 1999).
T15262	27780-27783	NN	denotes	DRG
T15263	27784-27791	NNS	denotes	neurons
T15264	27792-27799	VBP	denotes	express
T15265	27800-27804	NN	denotes	Robo
T15266	27805-27814	NNS	denotes	receptors
T15267	27814-27816	,	denotes	,
T15268	27816-27821	WDT	denotes	which
T15269	27822-27826	VBP	denotes	bind
T15270	27827-27829	IN	denotes	to
T15271	27830-27835	NNS	denotes	Slits
T15272	27835-27837	,	denotes	,
T15273	27837-27840	CC	denotes	and
T15274	27841-27855	JJ	denotes	proprioceptive
T15275	27856-27861	NNS	denotes	axons
T15276	27862-27865	VBP	denotes	are
T15277	27866-27875	RB	denotes	therefore
T15278	27876-27883	JJ	denotes	capable
T15279	27884-27886	IN	denotes	of
T15280	27887-27897	VBG	denotes	responding
T15281	27898-27900	IN	denotes	to
T15282	27901-27905	NN	denotes	Slit
T15283	27906-27913	NNS	denotes	signals
T15284	27914-27915	-LRB-	denotes	(
T15285	27915-27919	NNP	denotes	Wang
T15286	27920-27922	FW	denotes	et
T15287	27923-27926	FW	denotes	al.
T15288	27927-27931	CD	denotes	1999
T15289	27931-27932	-RRB-	denotes	)
T15290	27932-27933	.	denotes	.
T15291	27933-28149	sentence	denotes	Slit2 does not cause repulsion of NT-3-responsive DRG axons in vitro (Nguyen Ba-Charvet et al. 2001), but causes ectopic branching and arborization of trigeminal axons in the brainstem (Özdinler and Erzurumlu 2002).
T15292	27934-27939	NN	denotes	Slit2
T15294	27940-27944	VBZ	denotes	does
T15295	27945-27948	RB	denotes	not
T15293	27949-27954	VB	denotes	cause
T15296	27955-27964	NN	denotes	repulsion
T15297	27965-27967	IN	denotes	of
T15298	27968-27970	NN	denotes	NT
T15300	27970-27971	HYPH	denotes	-
T15301	27971-27972	CD	denotes	3
T15302	27972-27973	HYPH	denotes	-
T15299	27973-27983	JJ	denotes	responsive
T15304	27984-27987	NN	denotes	DRG
T15303	27988-27993	NNS	denotes	axons
T15305	27994-27996	FW	denotes	in
T15306	27997-28002	FW	denotes	vitro
T15307	28003-28004	-LRB-	denotes	(
T15308	28004-28010	NNP	denotes	Nguyen
T15309	28011-28013	NNP	denotes	Ba
T15310	28013-28014	HYPH	denotes	-
T15311	28014-28021	NNP	denotes	Charvet
T15312	28022-28024	FW	denotes	et
T15313	28025-28028	FW	denotes	al.
T15314	28029-28033	CD	denotes	2001
T15315	28033-28034	-RRB-	denotes	)
T15316	28034-28036	,	denotes	,
T15317	28036-28039	CC	denotes	but
T15318	28040-28046	VBZ	denotes	causes
T15319	28047-28054	JJ	denotes	ectopic
T15320	28055-28064	NN	denotes	branching
T15321	28065-28068	CC	denotes	and
T15322	28069-28081	NN	denotes	arborization
T15323	28082-28084	IN	denotes	of
T15324	28085-28095	JJ	denotes	trigeminal
T15325	28096-28101	NNS	denotes	axons
T15326	28102-28104	IN	denotes	in
T15327	28105-28108	DT	denotes	the
T15328	28109-28118	NN	denotes	brainstem
T15329	28119-28120	-LRB-	denotes	(
T15330	28120-28128	NNP	denotes	Özdinler
T15331	28129-28132	CC	denotes	and
T15332	28133-28142	NNP	denotes	Erzurumlu
T15333	28143-28147	CD	denotes	2002
T15334	28147-28148	-RRB-	denotes	)
T15335	28148-28149	.	denotes	.
T15336	28149-28306	sentence	denotes	Thus, Slit2 might also be involved in terminal branching of propioceptive axons in the ventral cord and in the midline branching observed in our double KOs.
T15337	28150-28154	RB	denotes	Thus
T15339	28154-28156	,	denotes	,
T15340	28156-28161	NN	denotes	Slit2
T15341	28162-28167	MD	denotes	might
T15342	28168-28172	RB	denotes	also
T15343	28173-28175	VB	denotes	be
T15338	28176-28184	VBN	denotes	involved
T15344	28185-28187	IN	denotes	in
T15345	28188-28196	JJ	denotes	terminal
T15346	28197-28206	NN	denotes	branching
T15347	28207-28209	IN	denotes	of
T15348	28210-28223	JJ	denotes	propioceptive
T15349	28224-28229	NNS	denotes	axons
T15350	28230-28232	IN	denotes	in
T15351	28233-28236	DT	denotes	the
T15353	28237-28244	JJ	denotes	ventral
T15352	28245-28249	NN	denotes	cord
T15354	28250-28253	CC	denotes	and
T15355	28254-28256	IN	denotes	in
T15356	28257-28260	DT	denotes	the
T15358	28261-28268	NN	denotes	midline
T15357	28269-28278	NN	denotes	branching
T15359	28279-28287	VBN	denotes	observed
T15360	28288-28290	IN	denotes	in
T15361	28291-28294	PRP$	denotes	our
T15363	28295-28301	JJ	denotes	double
T15362	28302-28305	NNS	denotes	KOs
T15364	28305-28306	.	denotes	.
T15365	28306-28459	sentence	denotes	Lack of PV expression in Bax/NT-3 KO mice suggests that PV expression might be responsible for proper axon targeting and muscle spindle differentiation.
T15366	28307-28311	NN	denotes	Lack
T15368	28312-28314	IN	denotes	of
T15369	28315-28317	NN	denotes	PV
T15370	28318-28328	NN	denotes	expression
T15371	28329-28331	IN	denotes	in
T15372	28332-28335	NN	denotes	Bax
T15374	28335-28336	HYPH	denotes	/
T15375	28336-28338	NN	denotes	NT
T15376	28338-28339	HYPH	denotes	-
T15377	28339-28340	CD	denotes	3
T15373	28341-28343	NN	denotes	KO
T15378	28344-28348	NNS	denotes	mice
T15367	28349-28357	VBZ	denotes	suggests
T15379	28358-28362	IN	denotes	that
T15381	28363-28365	NN	denotes	PV
T15382	28366-28376	NN	denotes	expression
T15383	28377-28382	MD	denotes	might
T15380	28383-28385	VB	denotes	be
T15384	28386-28397	JJ	denotes	responsible
T15385	28398-28401	IN	denotes	for
T15386	28402-28408	JJ	denotes	proper
T15388	28409-28413	NN	denotes	axon
T15387	28414-28423	NN	denotes	targeting
T15389	28424-28427	CC	denotes	and
T15390	28428-28434	NN	denotes	muscle
T15391	28435-28442	NN	denotes	spindle
T15392	28443-28458	NN	denotes	differentiation
T15393	28458-28459	.	denotes	.
T15394	28459-28517	sentence	denotes	Presently we cannot completely rule out this possibility.
T15395	28460-28469	RB	denotes	Presently
T15397	28470-28472	PRP	denotes	we
T15398	28473-28476	MD	denotes	can
T15399	28476-28479	RB	denotes	not
T15400	28480-28490	RB	denotes	completely
T15396	28491-28495	VB	denotes	rule
T15401	28496-28499	RP	denotes	out
T15402	28500-28504	DT	denotes	this
T15403	28505-28516	NN	denotes	possibility
T15404	28516-28517	.	denotes	.
T15405	28517-28775	sentence	denotes	However, no defects in axon pathfinding along the monosynaptic reflex arc or in muscle spindle differentiation have been noted in PV KO mice, which develop normally and show no apparent changes in their behavior or physical activity (Schwaller et al. 1999).
T15406	28518-28525	RB	denotes	However
T15408	28525-28527	,	denotes	,
T15409	28527-28529	DT	denotes	no
T15410	28530-28537	NNS	denotes	defects
T15411	28538-28540	IN	denotes	in
T15412	28541-28545	NN	denotes	axon
T15413	28546-28557	NN	denotes	pathfinding
T15414	28558-28563	IN	denotes	along
T15415	28564-28567	DT	denotes	the
T15417	28568-28580	JJ	denotes	monosynaptic
T15418	28581-28587	NN	denotes	reflex
T15416	28588-28591	NN	denotes	arc
T15419	28592-28594	CC	denotes	or
T15420	28595-28597	IN	denotes	in
T15421	28598-28604	NN	denotes	muscle
T15422	28605-28612	NN	denotes	spindle
T15423	28613-28628	NN	denotes	differentiation
T15424	28629-28633	VBP	denotes	have
T15425	28634-28638	VBN	denotes	been
T15407	28639-28644	VBN	denotes	noted
T15426	28645-28647	IN	denotes	in
T15427	28648-28650	NN	denotes	PV
T15428	28651-28653	NN	denotes	KO
T15429	28654-28658	NNS	denotes	mice
T15430	28658-28660	,	denotes	,
T15431	28660-28665	WDT	denotes	which
T15432	28666-28673	VBP	denotes	develop
T15433	28674-28682	RB	denotes	normally
T15434	28683-28686	CC	denotes	and
T15435	28687-28691	VBP	denotes	show
T15436	28692-28694	DT	denotes	no
T15438	28695-28703	JJ	denotes	apparent
T15437	28704-28711	NNS	denotes	changes
T15439	28712-28714	IN	denotes	in
T15440	28715-28720	PRP$	denotes	their
T15441	28721-28729	NN	denotes	behavior
T15442	28730-28732	CC	denotes	or
T15443	28733-28741	JJ	denotes	physical
T15444	28742-28750	NN	denotes	activity
T15445	28751-28752	-LRB-	denotes	(
T15446	28752-28761	NNP	denotes	Schwaller
T15447	28762-28764	FW	denotes	et
T15448	28765-28768	FW	denotes	al.
T15449	28769-28773	CD	denotes	1999
T15450	28773-28774	-RRB-	denotes	)
T15451	28774-28775	.	denotes	.
T15452	28775-28930	sentence	denotes	These observations suggest that axonal targeting defects in Bax/NT-3 double KO mice cannot be simply due to lack of PV expression in proprioceptive cells.
T15453	28776-28781	DT	denotes	These
T15454	28782-28794	NNS	denotes	observations
T15455	28795-28802	VBP	denotes	suggest
T15456	28803-28807	IN	denotes	that
T15458	28808-28814	JJ	denotes	axonal
T15460	28815-28824	VBG	denotes	targeting
T15459	28825-28832	NNS	denotes	defects
T15461	28833-28835	IN	denotes	in
T15462	28836-28839	NN	denotes	Bax
T15464	28839-28840	HYPH	denotes	/
T15465	28840-28842	NN	denotes	NT
T15466	28842-28843	HYPH	denotes	-
T15467	28843-28844	CD	denotes	3
T15468	28845-28851	JJ	denotes	double
T15463	28852-28854	NN	denotes	KO
T15469	28855-28859	NNS	denotes	mice
T15470	28860-28863	MD	denotes	can
T15471	28863-28866	RB	denotes	not
T15457	28867-28869	VB	denotes	be
T15472	28870-28876	RB	denotes	simply
T15473	28877-28880	IN	denotes	due
T15474	28881-28883	IN	denotes	to
T15475	28884-28888	NN	denotes	lack
T15476	28889-28891	IN	denotes	of
T15477	28892-28894	NN	denotes	PV
T15478	28895-28905	NN	denotes	expression
T15479	28906-28908	IN	denotes	in
T15480	28909-28923	JJ	denotes	proprioceptive
T15481	28924-28929	NNS	denotes	cells
T15482	28929-28930	.	denotes	.
T15483	28930-29127	sentence	denotes	Our present results suggest that NT-3 acts as a short-range axon guidance cue for proprioceptive axons centrally and peripherally, as they navigate to their targets using other axon guidance cues.
T15484	28931-28934	PRP$	denotes	Our
T15486	28935-28942	JJ	denotes	present
T15485	28943-28950	NNS	denotes	results
T15487	28951-28958	VBP	denotes	suggest
T15488	28959-28963	IN	denotes	that
T15490	28964-28966	NN	denotes	NT
T15491	28966-28967	HYPH	denotes	-
T15492	28967-28968	CD	denotes	3
T15489	28969-28973	VBZ	denotes	acts
T15493	28974-28976	IN	denotes	as
T15494	28977-28978	DT	denotes	a
T15496	28979-28984	JJ	denotes	short
T15498	28984-28985	HYPH	denotes	-
T15497	28985-28990	NN	denotes	range
T15499	28991-28995	NN	denotes	axon
T15500	28996-29004	NN	denotes	guidance
T15495	29005-29008	NN	denotes	cue
T15501	29009-29012	IN	denotes	for
T15502	29013-29027	JJ	denotes	proprioceptive
T15503	29028-29033	NNS	denotes	axons
T15504	29034-29043	RB	denotes	centrally
T15505	29044-29047	CC	denotes	and
T15506	29048-29060	RB	denotes	peripherally
T15507	29060-29062	,	denotes	,
T15508	29062-29064	IN	denotes	as
T15510	29065-29069	PRP	denotes	they
T15509	29070-29078	VBP	denotes	navigate
T15511	29079-29081	IN	denotes	to
T15512	29082-29087	PRP$	denotes	their
T15513	29088-29095	NNS	denotes	targets
T15514	29096-29101	VBG	denotes	using
T15515	29102-29107	JJ	denotes	other
T15517	29108-29112	NN	denotes	axon
T15518	29113-29121	NN	denotes	guidance
T15516	29122-29126	NNS	denotes	cues
T15519	29126-29127	.	denotes	.
T15520	29127-29188	sentence	denotes	In its absence, these axons terminate in inappropriate loci.
T15521	29128-29130	IN	denotes	In
T15523	29131-29134	PRP$	denotes	its
T15524	29135-29142	NN	denotes	absence
T15525	29142-29144	,	denotes	,
T15526	29144-29149	DT	denotes	these
T15527	29150-29155	NNS	denotes	axons
T15522	29156-29165	VBP	denotes	terminate
T15528	29166-29168	IN	denotes	in
T15529	29169-29182	JJ	denotes	inappropriate
T15530	29183-29187	NNS	denotes	loci
T15531	29187-29188	.	denotes	.
T15532	29188-29330	sentence	denotes	However, NT-3 may not be the only molecule that plays a role in targeting and terminal branching of sensory axons in the ventral spinal cord.
T15533	29189-29196	RB	denotes	However
T15535	29196-29198	,	denotes	,
T15536	29198-29200	NN	denotes	NT
T15537	29200-29201	HYPH	denotes	-
T15538	29201-29202	CD	denotes	3
T15539	29203-29206	MD	denotes	may
T15540	29207-29210	RB	denotes	not
T15534	29211-29213	VB	denotes	be
T15541	29214-29217	DT	denotes	the
T15543	29218-29222	JJ	denotes	only
T15542	29223-29231	NN	denotes	molecule
T15544	29232-29236	WDT	denotes	that
T15545	29237-29242	VBZ	denotes	plays
T15546	29243-29244	DT	denotes	a
T15547	29245-29249	NN	denotes	role
T15548	29250-29252	IN	denotes	in
T15549	29253-29262	VBG	denotes	targeting
T15550	29263-29266	CC	denotes	and
T15551	29267-29275	JJ	denotes	terminal
T15552	29276-29285	NN	denotes	branching
T15553	29286-29288	IN	denotes	of
T15554	29289-29296	JJ	denotes	sensory
T15555	29297-29302	NNS	denotes	axons
T15556	29303-29305	IN	denotes	in
T15557	29306-29309	DT	denotes	the
T15559	29310-29317	JJ	denotes	ventral
T15560	29318-29324	JJ	denotes	spinal
T15558	29325-29329	NN	denotes	cord
T15561	29329-29330	.	denotes	.
T15562	29330-29535	sentence	denotes	NT-3 most likely acts cooperatively with other axon guidance molecules or by regulating expression of yet to be identified proprioceptive neuron-specific receptors/ligands for numerous axon guidance cues.
T15563	29331-29333	NN	denotes	NT
T15565	29333-29334	HYPH	denotes	-
T15566	29334-29335	CD	denotes	3
T15567	29336-29340	RBS	denotes	most
T15568	29341-29347	RB	denotes	likely
T15564	29348-29352	VBZ	denotes	acts
T15569	29353-29366	RB	denotes	cooperatively
T15570	29367-29371	IN	denotes	with
T15571	29372-29377	JJ	denotes	other
T15573	29378-29382	NN	denotes	axon
T15574	29383-29391	NN	denotes	guidance
T15572	29392-29401	NNS	denotes	molecules
T15575	29402-29404	CC	denotes	or
T15576	29405-29407	IN	denotes	by
T15577	29408-29418	VBG	denotes	regulating
T15578	29419-29429	NN	denotes	expression
T15579	29430-29432	IN	denotes	of
T15580	29433-29436	RB	denotes	yet
T15582	29437-29439	TO	denotes	to
T15583	29440-29442	VB	denotes	be
T15581	29443-29453	VBN	denotes	identified
T15584	29454-29468	JJ	denotes	proprioceptive
T15585	29469-29475	NN	denotes	neuron
T15587	29475-29476	HYPH	denotes	-
T15586	29476-29484	JJ	denotes	specific
T15588	29485-29494	NNS	denotes	receptors
T15590	29494-29495	HYPH	denotes	/
T15589	29495-29502	NNS	denotes	ligands
T15591	29503-29506	IN	denotes	for
T15592	29507-29515	JJ	denotes	numerous
T15594	29516-29520	NN	denotes	axon
T15595	29521-29529	NN	denotes	guidance
T15593	29530-29534	NNS	denotes	cues
T15596	29534-29535	.	denotes	.
T16203	29560-29570	NN	denotes	Generation
T16204	29571-29573	IN	denotes	of
T16205	29574-29580	JJ	denotes	double
T16206	29581-29584	NNS	denotes	KOs
T16207	29584-29585	.	denotes	.
T16208	29585-29781	sentence	denotes	We crossed Bax KO females on a C57BL/6 background (Jackson Laboratory, Bar Harbor, Maine, United States) to NT-3 heterozygote males on a 129 Sv background to generate double heterozygote animals.
T16209	29586-29588	PRP	denotes	We
T16210	29589-29596	VBD	denotes	crossed
T16211	29597-29600	NN	denotes	Bax
T16212	29601-29603	NN	denotes	KO
T16213	29604-29611	NNS	denotes	females
T16214	29612-29614	IN	denotes	on
T16215	29615-29616	DT	denotes	a
T16217	29617-29622	NN	denotes	C57BL
T16218	29622-29623	HYPH	denotes	/
T16219	29623-29624	CD	denotes	6
T16216	29625-29635	NN	denotes	background
T16220	29636-29637	-LRB-	denotes	(
T16222	29637-29644	NNP	denotes	Jackson
T16221	29645-29655	NNP	denotes	Laboratory
T16223	29655-29657	,	denotes	,
T16224	29657-29660	NNP	denotes	Bar
T16225	29661-29667	NNP	denotes	Harbor
T16226	29667-29669	,	denotes	,
T16227	29669-29674	NNP	denotes	Maine
T16228	29674-29676	,	denotes	,
T16229	29676-29682	NNP	denotes	United
T16230	29683-29689	NNP	denotes	States
T16231	29689-29690	-RRB-	denotes	)
T16232	29691-29693	IN	denotes	to
T16233	29694-29696	NN	denotes	NT
T16235	29696-29697	HYPH	denotes	-
T16236	29697-29698	CD	denotes	3
T16234	29699-29711	NN	denotes	heterozygote
T16237	29712-29717	NNS	denotes	males
T16238	29718-29720	IN	denotes	on
T16239	29721-29722	DT	denotes	a
T16241	29723-29726	CD	denotes	129
T16242	29727-29729	NN	denotes	Sv
T16240	29730-29740	NN	denotes	background
T16243	29741-29743	TO	denotes	to
T16244	29744-29752	VB	denotes	generate
T16245	29753-29759	JJ	denotes	double
T16246	29760-29772	NN	denotes	heterozygote
T16247	29773-29780	NNS	denotes	animals
T16248	29780-29781	.	denotes	.
T16249	29781-29889	sentence	denotes	Progeny was genotyped with PCR, and animals heterozygous for both genes were bred to obtain the double KOs.
T16250	29782-29789	NN	denotes	Progeny
T16252	29790-29793	VBD	denotes	was
T16251	29794-29803	VBN	denotes	genotyped
T16253	29804-29808	IN	denotes	with
T16254	29809-29812	NN	denotes	PCR
T16255	29812-29814	,	denotes	,
T16256	29814-29817	CC	denotes	and
T16257	29818-29825	NNS	denotes	animals
T16259	29826-29838	JJ	denotes	heterozygous
T16260	29839-29842	IN	denotes	for
T16261	29843-29847	DT	denotes	both
T16262	29848-29853	NNS	denotes	genes
T16263	29854-29858	VBD	denotes	were
T16258	29859-29863	VBN	denotes	bred
T16264	29864-29866	TO	denotes	to
T16265	29867-29873	VB	denotes	obtain
T16266	29874-29877	DT	denotes	the
T16268	29878-29884	JJ	denotes	double
T16267	29885-29888	NNS	denotes	KOs
T16269	29888-29889	.	denotes	.
T16270	29889-30032	sentence	denotes	Primers used for the Bax locus were R661, GTT GAC CAG AGT GGC GTA GG; R662, CCG CTT CCA TTG CTC AGC GG; and R663, GAG CTG ATC AGA ACC ATC ATG.
T16271	29890-29897	NNS	denotes	Primers
T16273	29898-29902	VBN	denotes	used
T16274	29903-29906	IN	denotes	for
T16275	29907-29910	DT	denotes	the
T16277	29911-29914	NN	denotes	Bax
T16276	29915-29920	NN	denotes	locus
T16272	29921-29925	VBD	denotes	were
T16278	29926-29930	NN	denotes	R661
T16279	29930-29932	,	denotes	,
T16280	29932-29935	NN	denotes	GTT
T16282	29936-29939	NN	denotes	GAC
T16283	29940-29943	NN	denotes	CAG
T16284	29944-29947	NN	denotes	AGT
T16285	29948-29951	NN	denotes	GGC
T16286	29952-29955	NN	denotes	GTA
T16281	29956-29958	NN	denotes	GG
T16287	29958-29959	:	denotes	;
T16288	29960-29964	NN	denotes	R662
T16289	29964-29966	,	denotes	,
T16290	29966-29969	NN	denotes	CCG
T16292	29970-29973	NN	denotes	CTT
T16293	29974-29977	NN	denotes	CCA
T16294	29978-29981	NN	denotes	TTG
T16295	29982-29985	NN	denotes	CTC
T16296	29986-29989	NN	denotes	AGC
T16291	29990-29992	NN	denotes	GG
T16297	29992-29993	:	denotes	;
T16298	29994-29997	CC	denotes	and
T16299	29998-30002	NN	denotes	R663
T16300	30002-30004	,	denotes	,
T16301	30004-30007	NN	denotes	GAG
T16303	30008-30011	NN	denotes	CTG
T16304	30012-30015	NN	denotes	ATC
T16305	30016-30019	NN	denotes	AGA
T16306	30020-30023	NN	denotes	ACC
T16307	30024-30027	NN	denotes	ATC
T16302	30028-30031	NN	denotes	ATG
T16308	30031-30032	.	denotes	.
T16309	30032-30215	sentence	denotes	Primers used for the NT-3 locus were NT3A, CGT GGT GAG GTT CTA TTG GCT AC; NT3B, CAG AGC ACC CTG CCC AAA GCA GAG; NT3R, CCT TGA CAA TAC TGA ATG CC; and NEOF, GGG AAC TTC CTG ACT AGG.
T16310	30033-30040	NNS	denotes	Primers
T16312	30041-30045	VBN	denotes	used
T16313	30046-30049	IN	denotes	for
T16314	30050-30053	DT	denotes	the
T16316	30054-30056	NN	denotes	NT
T16317	30056-30057	HYPH	denotes	-
T16318	30057-30058	CD	denotes	3
T16315	30059-30064	NN	denotes	locus
T16311	30065-30069	VBD	denotes	were
T16319	30070-30074	NN	denotes	NT3A
T16320	30074-30076	,	denotes	,
T16321	30076-30079	NN	denotes	CGT
T16323	30080-30083	NN	denotes	GGT
T16324	30084-30087	NN	denotes	GAG
T16325	30088-30091	NN	denotes	GTT
T16326	30092-30095	NN	denotes	CTA
T16327	30096-30099	NN	denotes	TTG
T16328	30100-30103	NN	denotes	GCT
T16322	30104-30106	NN	denotes	AC
T16329	30106-30107	:	denotes	;
T16330	30108-30112	NN	denotes	NT3B
T16331	30112-30114	,	denotes	,
T16332	30114-30117	NN	denotes	CAG
T16334	30118-30121	NN	denotes	AGC
T16335	30122-30125	NN	denotes	ACC
T16336	30126-30129	NN	denotes	CTG
T16337	30130-30133	NN	denotes	CCC
T16338	30134-30137	NN	denotes	AAA
T16339	30138-30141	NN	denotes	GCA
T16333	30142-30145	NN	denotes	GAG
T16340	30145-30146	:	denotes	;
T16341	30147-30151	NN	denotes	NT3R
T16342	30151-30153	,	denotes	,
T16343	30153-30156	NN	denotes	CCT
T16345	30157-30160	NN	denotes	TGA
T16346	30161-30164	NN	denotes	CAA
T16347	30165-30168	NN	denotes	TAC
T16348	30169-30172	NN	denotes	TGA
T16349	30173-30176	NN	denotes	ATG
T16344	30177-30179	NN	denotes	CC
T16350	30179-30180	:	denotes	;
T16351	30181-30184	CC	denotes	and
T16352	30185-30189	NN	denotes	NEOF
T16353	30189-30191	,	denotes	,
T16354	30191-30194	NN	denotes	GGG
T16356	30195-30198	NN	denotes	AAC
T16357	30199-30202	NN	denotes	TTC
T16358	30203-30206	NN	denotes	CTG
T16359	30207-30210	NN	denotes	ACT
T16355	30211-30214	NN	denotes	AGG
T16360	30214-30215	.	denotes	.
T16361	30215-30274	sentence	denotes	WT, Bax KO, and NT-3 KO littermates were used as controls.
T16362	30216-30218	NN	denotes	WT
T16364	30218-30220	,	denotes	,
T16365	30220-30223	NN	denotes	Bax
T16366	30224-30226	NN	denotes	KO
T16367	30226-30228	,	denotes	,
T16368	30228-30231	CC	denotes	and
T16369	30232-30234	NN	denotes	NT
T16371	30234-30235	HYPH	denotes	-
T16372	30235-30236	CD	denotes	3
T16370	30237-30239	NN	denotes	KO
T16363	30240-30251	NNS	denotes	littermates
T16374	30252-30256	VBD	denotes	were
T16373	30257-30261	VBN	denotes	used
T16375	30262-30264	IN	denotes	as
T16376	30265-30273	NNS	denotes	controls
T16377	30273-30274	.	denotes	.
T16378	30274-30355	sentence	denotes	A total of 11 Bax/NT-3 double KO mice were analyzed, of these nine were P0 pups.
T16379	30275-30276	DT	denotes	A
T16380	30277-30282	NN	denotes	total
T16382	30283-30285	IN	denotes	of
T16383	30286-30288	CD	denotes	11
T16385	30289-30292	NN	denotes	Bax
T16387	30292-30293	HYPH	denotes	/
T16388	30293-30295	NN	denotes	NT
T16389	30295-30296	HYPH	denotes	-
T16390	30296-30297	CD	denotes	3
T16391	30298-30304	JJ	denotes	double
T16386	30305-30307	NN	denotes	KO
T16384	30308-30312	NNS	denotes	mice
T16392	30313-30317	VBD	denotes	were
T16381	30318-30326	VBN	denotes	analyzed
T16394	30326-30328	,	denotes	,
T16395	30328-30330	IN	denotes	of
T16396	30331-30336	DT	denotes	these
T16397	30337-30341	CD	denotes	nine
T16393	30342-30346	VBD	denotes	were
T16398	30347-30349	NN	denotes	P0
T16399	30350-30354	NNS	denotes	pups
T16400	30354-30355	.	denotes	.
T16401	30355-30431	sentence	denotes	The p75 colony on a 129 S1 background was received from Jackson Laboratory.
T16402	30356-30359	DT	denotes	The
T16404	30360-30363	NN	denotes	p75
T16403	30364-30370	NN	denotes	colony
T16406	30371-30373	IN	denotes	on
T16407	30374-30375	DT	denotes	a
T16409	30376-30379	CD	denotes	129
T16410	30380-30382	NN	denotes	S1
T16408	30383-30393	NN	denotes	background
T16411	30394-30397	VBD	denotes	was
T16405	30398-30406	VBN	denotes	received
T16412	30407-30411	IN	denotes	from
T16413	30412-30419	NNP	denotes	Jackson
T16414	30420-30430	NNP	denotes	Laboratory
T16415	30430-30431	.	denotes	.
T16416	30431-30677	sentence	denotes	We used tail DNA to genotype animals using the primers IMR0013, CTT GGG TGG AGA GGC TAT TC; IMR0014, AGG TGA GAT GAC AGG AGA TC (generic neo primers); IMR0710, TGT TAC GTT CTC TGA CGT GGT GAG; and IMR0711, TCA GCC CAG GGT GTG CAC TC (p75 locus).
T16417	30432-30434	PRP	denotes	We
T16418	30435-30439	VBD	denotes	used
T16419	30440-30444	NN	denotes	tail
T16420	30445-30448	NN	denotes	DNA
T16421	30449-30451	TO	denotes	to
T16422	30452-30460	VB	denotes	genotype
T16423	30461-30468	NNS	denotes	animals
T16424	30469-30474	VBG	denotes	using
T16425	30475-30478	DT	denotes	the
T16426	30479-30486	NNS	denotes	primers
T16427	30487-30494	NN	denotes	IMR0013
T16428	30494-30496	,	denotes	,
T16429	30496-30499	NN	denotes	CTT
T16431	30500-30503	NN	denotes	GGG
T16432	30504-30507	NN	denotes	TGG
T16433	30508-30511	NN	denotes	AGA
T16434	30512-30515	NN	denotes	GGC
T16435	30516-30519	NN	denotes	TAT
T16430	30520-30522	NN	denotes	TC
T16436	30522-30523	:	denotes	;
T16437	30524-30531	NN	denotes	IMR0014
T16438	30531-30533	,	denotes	,
T16439	30533-30536	NN	denotes	AGG
T16441	30537-30540	NN	denotes	TGA
T16442	30541-30544	NN	denotes	GAT
T16443	30545-30548	NN	denotes	GAC
T16444	30549-30552	NN	denotes	AGG
T16445	30553-30556	NN	denotes	AGA
T16440	30557-30559	NN	denotes	TC
T16446	30560-30561	-LRB-	denotes	(
T16447	30561-30568	JJ	denotes	generic
T16449	30569-30572	NN	denotes	neo
T16448	30573-30580	NNS	denotes	primers
T16450	30580-30581	-RRB-	denotes	)
T16451	30581-30582	:	denotes	;
T16452	30583-30590	NN	denotes	IMR0710
T16453	30590-30592	,	denotes	,
T16454	30592-30595	NN	denotes	TGT
T16456	30596-30599	NN	denotes	TAC
T16457	30600-30603	NN	denotes	GTT
T16458	30604-30607	NN	denotes	CTC
T16459	30608-30611	NN	denotes	TGA
T16460	30612-30615	NN	denotes	CGT
T16461	30616-30619	NN	denotes	GGT
T16455	30620-30623	NN	denotes	GAG
T16462	30623-30624	:	denotes	;
T16463	30625-30628	CC	denotes	and
T16464	30629-30636	NN	denotes	IMR0711
T16465	30636-30638	,	denotes	,
T16466	30638-30641	NN	denotes	TCA
T16468	30642-30645	NN	denotes	GCC
T16469	30646-30649	NN	denotes	CAG
T16470	30650-30653	NN	denotes	GGT
T16471	30654-30657	NN	denotes	GTG
T16472	30658-30661	NN	denotes	CAC
T16467	30662-30664	NN	denotes	TC
T16473	30665-30666	-LRB-	denotes	(
T16475	30666-30669	NN	denotes	p75
T16474	30670-30675	NN	denotes	locus
T16476	30675-30676	-RRB-	denotes	)
T16477	30676-30677	.	denotes	.
T16478	30677-30746	sentence	denotes	For embryonic experiments, day of plug positivity was considered E0.
T16479	30678-30681	IN	denotes	For
T16481	30682-30691	JJ	denotes	embryonic
T16482	30692-30703	NNS	denotes	experiments
T16483	30703-30705	,	denotes	,
T16484	30705-30708	NN	denotes	day
T16485	30709-30711	IN	denotes	of
T16486	30712-30716	NN	denotes	plug
T16487	30717-30727	NN	denotes	positivity
T16488	30728-30731	VBD	denotes	was
T16480	30732-30742	VBN	denotes	considered
T16489	30743-30745	NN	denotes	E0
T16490	30745-30746	.	denotes	.
T16491	30746-30996	sentence	denotes	All of the protocols used in this study were approved by the Louisiana State University Health Sciences Center Institutional Animal Care and Use Committee and conformed to the National Institutes of Health guidelines for use of experimental animals.
T16492	30747-30750	DT	denotes	All
T16494	30751-30753	IN	denotes	of
T16495	30754-30757	DT	denotes	the
T16496	30758-30767	NNS	denotes	protocols
T16497	30768-30772	VBN	denotes	used
T16498	30773-30775	IN	denotes	in
T16499	30776-30780	DT	denotes	this
T16500	30781-30786	NN	denotes	study
T16501	30787-30791	VBD	denotes	were
T16493	30792-30800	VBN	denotes	approved
T16502	30801-30803	IN	denotes	by
T16503	30804-30807	DT	denotes	the
T16505	30808-30817	NNP	denotes	Louisiana
T16507	30818-30823	NNP	denotes	State
T16506	30824-30834	NNP	denotes	University
T16509	30835-30841	NNP	denotes	Health
T16510	30842-30850	NNPS	denotes	Sciences
T16508	30851-30857	NNP	denotes	Center
T16511	30858-30871	NNP	denotes	Institutional
T16512	30872-30878	NNP	denotes	Animal
T16513	30879-30883	NNP	denotes	Care
T16514	30884-30887	CC	denotes	and
T16515	30888-30891	NNP	denotes	Use
T16504	30892-30901	NNP	denotes	Committee
T16516	30902-30905	CC	denotes	and
T16517	30906-30915	VBD	denotes	conformed
T16518	30916-30918	IN	denotes	to
T16519	30919-30922	DT	denotes	the
T16521	30923-30931	NNP	denotes	National
T16522	30932-30942	NNPS	denotes	Institutes
T16523	30943-30945	IN	denotes	of
T16524	30946-30952	NNP	denotes	Health
T16520	30953-30963	NNS	denotes	guidelines
T16525	30964-30967	IN	denotes	for
T16526	30968-30971	NN	denotes	use
T16527	30972-30974	IN	denotes	of
T16528	30975-30987	JJ	denotes	experimental
T16529	30988-30995	NNS	denotes	animals
T16530	30995-30996	.	denotes	.
T16880	30998-31002	NN	denotes	TrkA
T16882	31002-31003	HYPH	denotes	/
T16881	31003-31007	NN	denotes	TrkC
T16883	31008-31028	NN	denotes	immunohistochemistry
T16884	31028-31029	.	denotes	.
T16885	31029-31427	sentence	denotes	Frozen spinal cord sections (10 μm thick) were blocked and incubated in a cocktail of rabbit anti-TrkA and goat anti-TrkC antibodies (gift of Dr. Reichardt; Huang et al. 1999), followed by a cocktail of CY3 conjugated donkey anti-rabbit and FITC conjugated donkey anti-goat antibodies (Chemicon, Temecula, California, United States) in the presence of 0.3% TritonX-100 and 10% normal donkey serum.
T16886	31030-31036	JJ	denotes	Frozen
T16888	31037-31043	JJ	denotes	spinal
T16889	31044-31048	NN	denotes	cord
T16887	31049-31057	NNS	denotes	sections
T16891	31058-31059	-LRB-	denotes	(
T16892	31059-31061	CD	denotes	10
T16893	31062-31064	NN	denotes	μm
T16894	31065-31070	JJ	denotes	thick
T16895	31070-31071	-RRB-	denotes	)
T16896	31072-31076	VBD	denotes	were
T16890	31077-31084	VBN	denotes	blocked
T16897	31085-31088	CC	denotes	and
T16898	31089-31098	VBN	denotes	incubated
T16899	31099-31101	IN	denotes	in
T16900	31102-31103	DT	denotes	a
T16901	31104-31112	NN	denotes	cocktail
T16902	31113-31115	IN	denotes	of
T16903	31116-31122	NN	denotes	rabbit
T16904	31123-31132	JJ	denotes	anti-TrkA
T16905	31133-31136	CC	denotes	and
T16906	31137-31141	NN	denotes	goat
T16908	31142-31151	JJ	denotes	anti-TrkC
T16907	31152-31162	NNS	denotes	antibodies
T16909	31163-31164	-LRB-	denotes	(
T16910	31164-31168	NN	denotes	gift
T16911	31169-31171	IN	denotes	of
T16912	31172-31175	NNP	denotes	Dr.
T16913	31176-31185	NNP	denotes	Reichardt
T16914	31185-31186	:	denotes	;
T16915	31187-31192	NNP	denotes	Huang
T16916	31193-31195	FW	denotes	et
T16917	31196-31199	FW	denotes	al.
T16918	31200-31204	CD	denotes	1999
T16919	31204-31205	-RRB-	denotes	)
T16920	31205-31207	,	denotes	,
T16921	31207-31215	VBN	denotes	followed
T16922	31216-31218	IN	denotes	by
T16923	31219-31220	DT	denotes	a
T16924	31221-31229	NN	denotes	cocktail
T16925	31230-31232	IN	denotes	of
T16926	31233-31236	NN	denotes	CY3
T16927	31237-31247	VBN	denotes	conjugated
T16928	31248-31254	NN	denotes	donkey
T16929	31255-31266	JJ	denotes	anti-rabbit
T16930	31267-31270	CC	denotes	and
T16931	31271-31275	NN	denotes	FITC
T16932	31276-31286	VBN	denotes	conjugated
T16933	31287-31293	NN	denotes	donkey
T16935	31294-31303	JJ	denotes	anti-goat
T16934	31304-31314	NNS	denotes	antibodies
T16936	31315-31316	-LRB-	denotes	(
T16937	31316-31324	NNP	denotes	Chemicon
T16938	31324-31326	,	denotes	,
T16939	31326-31334	NNP	denotes	Temecula
T16940	31334-31336	,	denotes	,
T16941	31336-31346	NNP	denotes	California
T16942	31346-31348	,	denotes	,
T16943	31348-31354	NNP	denotes	United
T16944	31355-31361	NNP	denotes	States
T16945	31361-31362	-RRB-	denotes	)
T16946	31363-31365	IN	denotes	in
T16947	31366-31369	DT	denotes	the
T16948	31370-31378	NN	denotes	presence
T16949	31379-31381	IN	denotes	of
T16950	31382-31385	CD	denotes	0.3
T16951	31385-31386	NN	denotes	%
T16952	31387-31394	NN	denotes	TritonX
T16953	31394-31395	HYPH	denotes	-
T16954	31395-31398	CD	denotes	100
T16955	31399-31402	CC	denotes	and
T16956	31403-31405	CD	denotes	10
T16957	31405-31406	NN	denotes	%
T16959	31407-31413	JJ	denotes	normal
T16960	31414-31420	NN	denotes	donkey
T16958	31421-31426	NN	denotes	serum
T16961	31426-31427	.	denotes	.
T16962	31427-31679	sentence	denotes	For PV immunohistochemistry, sections were reacted with monoclonal mouse anti-PV antibody (Sigma, St. Louis, Missouri, United States), and developed by Vector fluorescein mouse on mouse kit (Vector Laboratories, Burlingame, California, United States).
T16963	31428-31431	IN	denotes	For
T16965	31432-31434	NN	denotes	PV
T16966	31435-31455	NN	denotes	immunohistochemistry
T16967	31455-31457	,	denotes	,
T16968	31457-31465	NNS	denotes	sections
T16969	31466-31470	VBD	denotes	were
T16964	31471-31478	VBN	denotes	reacted
T16970	31479-31483	IN	denotes	with
T16971	31484-31494	JJ	denotes	monoclonal
T16973	31495-31500	NN	denotes	mouse
T16974	31501-31508	JJ	denotes	anti-PV
T16972	31509-31517	NN	denotes	antibody
T16975	31518-31519	-LRB-	denotes	(
T16976	31519-31524	NNP	denotes	Sigma
T16977	31524-31526	,	denotes	,
T16978	31526-31529	NNP	denotes	St.
T16979	31530-31535	NNP	denotes	Louis
T16980	31535-31537	,	denotes	,
T16981	31537-31545	NNP	denotes	Missouri
T16982	31545-31547	,	denotes	,
T16983	31547-31553	NNP	denotes	United
T16984	31554-31560	NNP	denotes	States
T16985	31560-31561	-RRB-	denotes	)
T16986	31561-31563	,	denotes	,
T16987	31563-31566	CC	denotes	and
T16988	31567-31576	VBN	denotes	developed
T16989	31577-31579	IN	denotes	by
T16990	31580-31586	NNP	denotes	Vector
T16991	31587-31598	NN	denotes	fluorescein
T16993	31599-31604	NN	denotes	mouse
T16994	31605-31607	IN	denotes	on
T16995	31608-31613	NN	denotes	mouse
T16992	31614-31617	NN	denotes	kit
T16996	31618-31619	-LRB-	denotes	(
T16998	31619-31625	NNP	denotes	Vector
T16997	31626-31638	NNP	denotes	Laboratories
T16999	31638-31640	,	denotes	,
T17000	31640-31650	NNP	denotes	Burlingame
T17001	31650-31652	,	denotes	,
T17002	31652-31662	NNP	denotes	California
T17003	31662-31664	,	denotes	,
T17004	31664-31670	NNP	denotes	United
T17005	31671-31677	NNP	denotes	States
T17006	31677-31678	-RRB-	denotes	)
T17007	31678-31679	.	denotes	.
T17008	31679-31829	sentence	denotes	For quantification purposes, TrkA- and TrkC-labeled cells from four different DRGs of each genotype and age studied were counted, and ratios plotted.
T17009	31680-31683	IN	denotes	For
T17011	31684-31698	NN	denotes	quantification
T17012	31699-31707	NNS	denotes	purposes
T17013	31707-31709	,	denotes	,
T17014	31709-31713	NN	denotes	TrkA
T17016	31713-31714	HYPH	denotes	-
T17017	31715-31718	CC	denotes	and
T17018	31719-31723	NN	denotes	TrkC
T17019	31723-31724	HYPH	denotes	-
T17015	31724-31731	VBN	denotes	labeled
T17020	31732-31737	NNS	denotes	cells
T17021	31738-31742	IN	denotes	from
T17022	31743-31747	CD	denotes	four
T17024	31748-31757	JJ	denotes	different
T17023	31758-31762	NNS	denotes	DRGs
T17025	31763-31765	IN	denotes	of
T17026	31766-31770	DT	denotes	each
T17027	31771-31779	NN	denotes	genotype
T17028	31780-31783	CC	denotes	and
T17029	31784-31787	NN	denotes	age
T17030	31788-31795	VBN	denotes	studied
T17031	31796-31800	VBD	denotes	were
T17010	31801-31808	VBN	denotes	counted
T17032	31808-31810	,	denotes	,
T17033	31810-31813	CC	denotes	and
T17034	31814-31820	NNS	denotes	ratios
T17035	31821-31828	VBN	denotes	plotted
T17036	31828-31829	.	denotes	.
T17352	31831-31837	NN	denotes	Muscle
T17353	31838-31845	NN	denotes	spindle
T17354	31846-31855	NN	denotes	detection
T17355	31855-31856	.	denotes	.
T17356	31856-32056	sentence	denotes	Gastrocnemius muscle was dissected out in P0 pups and sectioned longitudinally, or, in some cases, the whole leg at the level of gastrocnemius muscle with tibial nerve was sectioned in cross section.
T17357	31857-31870	NN	denotes	Gastrocnemius
T17358	31871-31877	NN	denotes	muscle
T17360	31878-31881	VBD	denotes	was
T17359	31882-31891	VBN	denotes	dissected
T17361	31892-31895	RP	denotes	out
T17362	31896-31898	IN	denotes	in
T17363	31899-31901	NN	denotes	P0
T17364	31902-31906	NNS	denotes	pups
T17365	31907-31910	CC	denotes	and
T17366	31911-31920	VBN	denotes	sectioned
T17367	31921-31935	RB	denotes	longitudinally
T17368	31935-31937	,	denotes	,
T17369	31937-31939	CC	denotes	or
T17370	31939-31941	,	denotes	,
T17371	31941-31943	IN	denotes	in
T17373	31944-31948	DT	denotes	some
T17374	31949-31954	NNS	denotes	cases
T17375	31954-31956	,	denotes	,
T17376	31956-31959	DT	denotes	the
T17378	31960-31965	JJ	denotes	whole
T17377	31966-31969	NN	denotes	leg
T17379	31970-31972	IN	denotes	at
T17380	31973-31976	DT	denotes	the
T17381	31977-31982	NN	denotes	level
T17382	31983-31985	IN	denotes	of
T17383	31986-31999	NN	denotes	gastrocnemius
T17384	32000-32006	NN	denotes	muscle
T17385	32007-32011	IN	denotes	with
T17386	32012-32018	JJ	denotes	tibial
T17387	32019-32024	NN	denotes	nerve
T17388	32025-32028	VBD	denotes	was
T17372	32029-32038	VBN	denotes	sectioned
T17389	32039-32041	IN	denotes	in
T17390	32042-32047	NN	denotes	cross
T17391	32048-32055	NN	denotes	section
T17392	32055-32056	.	denotes	.
T17393	32056-32414	sentence	denotes	Sections were incubated with monoclonal S46 antibody (gift of Dr. Stockdale) reactive to the spindle-specific slow-tonic myosin heavy chain isoform and developed by Vector mouse on mouse kit as described above, followed by rabbit anti-NF-M antibody (Chemicon) and CY3 conjugated goat anti-rabbit antibody (Chemicon) in a sequential double-labeling protocol.
T17394	32057-32065	NNS	denotes	Sections
T17396	32066-32070	VBD	denotes	were
T17395	32071-32080	VBN	denotes	incubated
T17397	32081-32085	IN	denotes	with
T17398	32086-32096	JJ	denotes	monoclonal
T17400	32097-32100	NN	denotes	S46
T17399	32101-32109	NN	denotes	antibody
T17401	32110-32111	-LRB-	denotes	(
T17402	32111-32115	NN	denotes	gift
T17403	32116-32118	IN	denotes	of
T17404	32119-32122	NNP	denotes	Dr.
T17405	32123-32132	NNP	denotes	Stockdale
T17406	32132-32133	-RRB-	denotes	)
T17407	32134-32142	JJ	denotes	reactive
T17408	32143-32145	IN	denotes	to
T17409	32146-32149	DT	denotes	the
T17411	32150-32157	NN	denotes	spindle
T17413	32157-32158	HYPH	denotes	-
T17412	32158-32166	JJ	denotes	specific
T17414	32167-32171	JJ	denotes	slow
T17416	32171-32172	HYPH	denotes	-
T17415	32172-32177	NN	denotes	tonic
T17417	32178-32184	NN	denotes	myosin
T17418	32185-32190	JJ	denotes	heavy
T17419	32191-32196	NN	denotes	chain
T17410	32197-32204	NN	denotes	isoform
T17420	32205-32208	CC	denotes	and
T17421	32209-32218	VBN	denotes	developed
T17422	32219-32221	IN	denotes	by
T17423	32222-32228	NNP	denotes	Vector
T17425	32229-32234	NN	denotes	mouse
T17426	32235-32237	IN	denotes	on
T17427	32238-32243	NN	denotes	mouse
T17424	32244-32247	NN	denotes	kit
T17428	32248-32250	IN	denotes	as
T17429	32251-32260	VBN	denotes	described
T17430	32261-32266	RB	denotes	above
T17431	32266-32268	,	denotes	,
T17432	32268-32276	VBN	denotes	followed
T17433	32277-32279	IN	denotes	by
T17434	32280-32286	NN	denotes	rabbit
T17436	32287-32294	JJ	denotes	anti-NF
T17438	32294-32295	HYPH	denotes	-
T17437	32295-32296	NN	denotes	M
T17435	32297-32305	NN	denotes	antibody
T17439	32306-32307	-LRB-	denotes	(
T17440	32307-32315	NNP	denotes	Chemicon
T17441	32315-32316	-RRB-	denotes	)
T17442	32317-32320	CC	denotes	and
T17443	32321-32324	NN	denotes	CY3
T17445	32325-32335	VBN	denotes	conjugated
T17446	32336-32340	NN	denotes	goat
T17447	32341-32352	JJ	denotes	anti-rabbit
T17444	32353-32361	NN	denotes	antibody
T17448	32362-32363	-LRB-	denotes	(
T17449	32363-32371	NNP	denotes	Chemicon
T17450	32371-32372	-RRB-	denotes	)
T17451	32373-32375	IN	denotes	in
T17452	32376-32377	DT	denotes	a
T17454	32378-32388	JJ	denotes	sequential
T17455	32389-32395	JJ	denotes	double
T17457	32395-32396	HYPH	denotes	-
T17456	32396-32404	NN	denotes	labeling
T17453	32405-32413	NN	denotes	protocol
T17458	32413-32414	.	denotes	.
T17459	32414-32611	sentence	denotes	In another method, DiI crystals were placed in DRGs of E17 embryos from different genotypes (n = 2), and the gastrocnemius muscle was isolated and sectioned into 40-μm-thick slices on a vibratome.
T17460	32415-32417	IN	denotes	In
T17462	32418-32425	DT	denotes	another
T17463	32426-32432	NN	denotes	method
T17464	32432-32434	,	denotes	,
T17465	32434-32437	NN	denotes	DiI
T17466	32438-32446	NNS	denotes	crystals
T17467	32447-32451	VBD	denotes	were
T17461	32452-32458	VBN	denotes	placed
T17468	32459-32461	IN	denotes	in
T17469	32462-32466	NNS	denotes	DRGs
T17470	32467-32469	IN	denotes	of
T17471	32470-32473	NN	denotes	E17
T17472	32474-32481	NNS	denotes	embryos
T17473	32482-32486	IN	denotes	from
T17474	32487-32496	JJ	denotes	different
T17475	32497-32506	NNS	denotes	genotypes
T17476	32507-32508	-LRB-	denotes	(
T17478	32508-32509	NN	denotes	n
T17479	32510-32511	SYM	denotes	=
T17477	32512-32513	CD	denotes	2
T17480	32513-32514	-RRB-	denotes	)
T17481	32514-32516	,	denotes	,
T17482	32516-32519	CC	denotes	and
T17483	32520-32523	DT	denotes	the
T17485	32524-32537	NN	denotes	gastrocnemius
T17484	32538-32544	NN	denotes	muscle
T17487	32545-32548	VBD	denotes	was
T17486	32549-32557	VBN	denotes	isolated
T17488	32558-32561	CC	denotes	and
T17489	32562-32571	VBN	denotes	sectioned
T17490	32572-32576	IN	denotes	into
T17491	32577-32579	CD	denotes	40
T17493	32579-32580	HYPH	denotes	-
T17492	32580-32582	NN	denotes	μm
T17495	32582-32583	HYPH	denotes	-
T17494	32583-32588	JJ	denotes	thick
T17496	32589-32595	NNS	denotes	slices
T17497	32596-32598	IN	denotes	on
T17498	32599-32600	DT	denotes	a
T17499	32601-32610	NN	denotes	vibratome
T17500	32610-32611	.	denotes	.
T17771	32613-32616	NN	denotes	DiI
T17772	32617-32625	NN	denotes	labeling
T17773	32625-32626	.	denotes	.
T17774	32626-32903	sentence	denotes	Spinal cords were dissected out with the DRGs attached, motor root was cut to prevent backfilling of motor neurons, and crystals of 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI; Molecular Probes, Eugene, Oregon, United States) were inserted in DRGs.
T17775	32627-32633	JJ	denotes	Spinal
T17776	32634-32639	NNS	denotes	cords
T17778	32640-32644	VBD	denotes	were
T17777	32645-32654	VBN	denotes	dissected
T17779	32655-32658	RP	denotes	out
T17780	32659-32663	IN	denotes	with
T17782	32664-32667	DT	denotes	the
T17783	32668-32672	NNS	denotes	DRGs
T17781	32673-32681	VBN	denotes	attached
T17784	32681-32683	,	denotes	,
T17785	32683-32688	NN	denotes	motor
T17786	32689-32693	NN	denotes	root
T17788	32694-32697	VBD	denotes	was
T17787	32698-32701	VBN	denotes	cut
T17789	32702-32704	TO	denotes	to
T17790	32705-32712	VB	denotes	prevent
T17791	32713-32724	NN	denotes	backfilling
T17792	32725-32727	IN	denotes	of
T17793	32728-32733	NN	denotes	motor
T17794	32734-32741	NNS	denotes	neurons
T17795	32741-32743	,	denotes	,
T17796	32743-32746	CC	denotes	and
T17797	32747-32755	NNS	denotes	crystals
T17799	32756-32758	IN	denotes	of
T17800	32759-32760	CD	denotes	1
T17802	32760-32761	,	denotes	,
T17803	32761-32762	CD	denotes	1
T17804	32762-32763	SYM	denotes	′
T17805	32763-32764	HYPH	denotes	-
T17806	32764-32775	NN	denotes	dioctadecyl
T17807	32775-32776	HYPH	denotes	-
T17808	32776-32777	CD	denotes	3
T17809	32777-32778	,	denotes	,
T17810	32778-32779	CD	denotes	3
T17811	32779-32780	,	denotes	,
T17812	32780-32781	CD	denotes	3
T17813	32781-32782	SYM	denotes	′
T17814	32782-32783	,	denotes	,
T17815	32783-32784	CD	denotes	3
T17816	32784-32785	SYM	denotes	′
T17817	32785-32786	HYPH	denotes	-
T17818	32786-32813	NN	denotes	tetramethylindocarbocyanine
T17801	32814-32825	NN	denotes	perchlorate
T17819	32826-32827	-LRB-	denotes	(
T17821	32827-32830	NN	denotes	DiI
T17822	32830-32831	:	denotes	;
T17823	32832-32841	NNP	denotes	Molecular
T17820	32842-32848	NNP	denotes	Probes
T17824	32848-32850	,	denotes	,
T17825	32850-32856	NNP	denotes	Eugene
T17826	32856-32858	,	denotes	,
T17827	32858-32864	NNP	denotes	Oregon
T17828	32864-32866	,	denotes	,
T17829	32866-32872	NNP	denotes	United
T17830	32873-32879	NNP	denotes	States
T17831	32879-32880	-RRB-	denotes	)
T17832	32881-32885	VBD	denotes	were
T17798	32886-32894	VBN	denotes	inserted
T17833	32895-32897	IN	denotes	in
T17834	32898-32902	NNS	denotes	DRGs
T17835	32902-32903	.	denotes	.
T17836	32903-32996	sentence	denotes	Labeled spinal cords were incubated at 37 °C for 8 d and sectioned on a vibrotome at 100 μm.
T17837	32904-32911	VBN	denotes	Labeled
T17839	32912-32918	JJ	denotes	spinal
T17838	32919-32924	NNS	denotes	cords
T17841	32925-32929	VBD	denotes	were
T17840	32930-32939	VBN	denotes	incubated
T17842	32940-32942	IN	denotes	at
T17843	32943-32945	CD	denotes	37
T17844	32946-32948	NN	denotes	°C
T17845	32949-32952	IN	denotes	for
T17846	32953-32954	CD	denotes	8
T17847	32955-32956	NN	denotes	d
T17848	32957-32960	CC	denotes	and
T17849	32961-32970	VBN	denotes	sectioned
T17850	32971-32973	IN	denotes	on
T17851	32974-32975	DT	denotes	a
T17852	32976-32985	NN	denotes	vibrotome
T17853	32986-32988	IN	denotes	at
T17854	32989-32992	CD	denotes	100
T17855	32993-32995	NN	denotes	μm
T17856	32995-32996	.	denotes	.
T17857	32996-33170	sentence	denotes	Sections were observed under the fluorescent microscope and photographed, and images were transferred to Adobe Photoshop, inverted, and adjusted for brightness and contrast.
T17858	32997-33005	NNS	denotes	Sections
T17860	33006-33010	VBD	denotes	were
T17859	33011-33019	VBN	denotes	observed
T17861	33020-33025	IN	denotes	under
T17862	33026-33029	DT	denotes	the
T17864	33030-33041	JJ	denotes	fluorescent
T17863	33042-33052	NN	denotes	microscope
T17865	33053-33056	CC	denotes	and
T17866	33057-33069	VBN	denotes	photographed
T17867	33069-33071	,	denotes	,
T17868	33071-33074	CC	denotes	and
T17869	33075-33081	NNS	denotes	images
T17871	33082-33086	VBD	denotes	were
T17870	33087-33098	VBN	denotes	transferred
T17872	33099-33101	IN	denotes	to
T17873	33102-33107	NNP	denotes	Adobe
T17874	33108-33117	NNP	denotes	Photoshop
T17875	33117-33119	,	denotes	,
T17876	33119-33127	VBN	denotes	inverted
T17877	33127-33129	,	denotes	,
T17878	33129-33132	CC	denotes	and
T17879	33133-33141	VBN	denotes	adjusted
T17880	33142-33145	IN	denotes	for
T17881	33146-33156	NN	denotes	brightness
T17882	33157-33160	CC	denotes	and
T17883	33161-33169	NN	denotes	contrast
T17884	33169-33170	.	denotes	.
T17885	33170-33259	sentence	denotes	Photoconverted in 0.15% DAB (3,3′-diaminobenzidine; Sigma) in 0.1M Tris buffer (pH 8.2).
T17886	33171-33185	VBN	denotes	Photoconverted
T17887	33186-33188	IN	denotes	in
T17888	33189-33193	CD	denotes	0.15
T17889	33193-33194	NN	denotes	%
T17890	33195-33198	NN	denotes	DAB
T17891	33199-33200	-LRB-	denotes	(
T17893	33200-33201	CD	denotes	3
T17895	33201-33202	,	denotes	,
T17896	33202-33203	CD	denotes	3
T17897	33203-33204	SYM	denotes	′
T17898	33204-33205	HYPH	denotes	-
T17894	33205-33221	NN	denotes	diaminobenzidine
T17899	33221-33222	:	denotes	;
T17892	33223-33228	NNP	denotes	Sigma
T17900	33228-33229	-RRB-	denotes	)
T17901	33230-33232	IN	denotes	in
T17902	33233-33236	CD	denotes	0.1
T17903	33236-33237	NN	denotes	M
T17905	33238-33242	NN	denotes	Tris
T17904	33243-33249	NN	denotes	buffer
T17906	33250-33251	-LRB-	denotes	(
T17907	33251-33253	NN	denotes	pH
T17908	33254-33257	CD	denotes	8.2
T17909	33257-33258	-RRB-	denotes	)
T17910	33258-33259	.	denotes	.
T18468	33261-33263	FW	denotes	In
T18469	33264-33269	FW	denotes	vitro
T18471	33270-33280	NN	denotes	co-culture
T18470	33281-33286	NN	denotes	assay
T18472	33286-33287	.	denotes	.
T18473	33287-33377	sentence	denotes	DRG explants were derived from Swiss Webster, Bax null, and p75 null mouse embryos (E13).
T18474	33288-33291	NN	denotes	DRG
T18475	33292-33300	NNS	denotes	explants
T18477	33301-33305	VBD	denotes	were
T18476	33306-33313	VBN	denotes	derived
T18478	33314-33318	IN	denotes	from
T18479	33319-33324	NNP	denotes	Swiss
T18480	33325-33332	NNP	denotes	Webster
T18482	33332-33334	,	denotes	,
T18483	33334-33337	NNP	denotes	Bax
T18484	33338-33342	JJ	denotes	null
T18485	33342-33344	,	denotes	,
T18486	33344-33347	CC	denotes	and
T18487	33348-33351	NN	denotes	p75
T18488	33352-33356	JJ	denotes	null
T18489	33357-33362	NN	denotes	mouse
T18481	33363-33370	NNS	denotes	embryos
T18490	33371-33372	-LRB-	denotes	(
T18491	33372-33375	NN	denotes	E13
T18492	33375-33376	-RRB-	denotes	)
T18493	33376-33377	.	denotes	.
T18494	33377-33478	sentence	denotes	For collagen matrix assays, DRGs were dissected out under a stereomicroscope using tungsten needles.
T18495	33378-33381	IN	denotes	For
T18497	33382-33390	NN	denotes	collagen
T18498	33391-33397	NN	denotes	matrix
T18499	33398-33404	NNS	denotes	assays
T18500	33404-33406	,	denotes	,
T18501	33406-33410	NNS	denotes	DRGs
T18502	33411-33415	VBD	denotes	were
T18496	33416-33425	VBN	denotes	dissected
T18503	33426-33429	RP	denotes	out
T18504	33430-33435	IN	denotes	under
T18505	33436-33437	DT	denotes	a
T18506	33438-33454	NN	denotes	stereomicroscope
T18507	33455-33460	VBG	denotes	using
T18508	33461-33469	NN	denotes	tungsten
T18509	33470-33477	NNS	denotes	needles
T18510	33477-33478	.	denotes	.
T18511	33478-33664	sentence	denotes	Collagen matrix was prepared with 430 μl of collagen (3 mg/ml dissolved in 0.1M acetic acid, Sigma), 50 μl of 10X DMEM medium, and 2.5 μl of 0.8 M NaCa2, and the pH was adjusted to 7.5.
T18512	33479-33487	NN	denotes	Collagen
T18513	33488-33494	NN	denotes	matrix
T18515	33495-33498	VBD	denotes	was
T18514	33499-33507	VBN	denotes	prepared
T18516	33508-33512	IN	denotes	with
T18517	33513-33516	CD	denotes	430
T18518	33517-33519	NN	denotes	μl
T18519	33520-33522	IN	denotes	of
T18520	33523-33531	NN	denotes	collagen
T18521	33532-33533	-LRB-	denotes	(
T18523	33533-33534	CD	denotes	3
T18524	33535-33537	NN	denotes	mg
T18525	33537-33538	SYM	denotes	/
T18526	33538-33540	NN	denotes	ml
T18527	33541-33550	VBN	denotes	dissolved
T18528	33551-33553	IN	denotes	in
T18529	33554-33557	CD	denotes	0.1
T18530	33557-33558	NN	denotes	M
T18532	33559-33565	JJ	denotes	acetic
T18531	33566-33570	NN	denotes	acid
T18533	33570-33572	,	denotes	,
T18522	33572-33577	NNP	denotes	Sigma
T18534	33577-33578	-RRB-	denotes	)
T18535	33578-33580	,	denotes	,
T18536	33580-33582	CD	denotes	50
T18537	33583-33585	NN	denotes	μl
T18538	33586-33588	IN	denotes	of
T18539	33589-33591	CD	denotes	10
T18541	33591-33592	NN	denotes	X
T18540	33593-33597	NN	denotes	DMEM
T18542	33598-33604	NN	denotes	medium
T18543	33604-33606	,	denotes	,
T18544	33606-33609	CC	denotes	and
T18545	33610-33613	CD	denotes	2.5
T18546	33614-33616	NN	denotes	μl
T18547	33617-33619	IN	denotes	of
T18548	33620-33623	CD	denotes	0.8
T18549	33624-33625	NN	denotes	M
T18550	33626-33631	NN	denotes	NaCa2
T18551	33631-33633	,	denotes	,
T18552	33633-33636	CC	denotes	and
T18553	33637-33640	DT	denotes	the
T18554	33641-33643	NN	denotes	pH
T18556	33644-33647	VBD	denotes	was
T18555	33648-33656	VBN	denotes	adjusted
T18557	33657-33659	IN	denotes	to
T18558	33660-33663	CD	denotes	7.5
T18559	33663-33664	.	denotes	.
T18560	33664-33767	sentence	denotes	Individual ganglion explants were placed in 24-well plates and covered with freshly prepared collagen.
T18561	33665-33675	JJ	denotes	Individual
T18563	33676-33684	NN	denotes	ganglion
T18562	33685-33693	NNS	denotes	explants
T18565	33694-33698	VBD	denotes	were
T18564	33699-33705	VBN	denotes	placed
T18566	33706-33708	IN	denotes	in
T18567	33709-33711	CD	denotes	24
T18569	33711-33712	HYPH	denotes	-
T18568	33712-33716	NN	denotes	well
T18570	33717-33723	NNS	denotes	plates
T18571	33724-33727	CC	denotes	and
T18572	33728-33735	VBN	denotes	covered
T18573	33736-33740	IN	denotes	with
T18574	33741-33748	RB	denotes	freshly
T18575	33749-33757	VBN	denotes	prepared
T18576	33758-33766	NN	denotes	collagen
T18577	33766-33767	.	denotes	.
T18578	33767-33829	sentence	denotes	Sepharose beads with an average diameter of 150 μm were used.
T18579	33768-33777	NN	denotes	Sepharose
T18580	33778-33783	NNS	denotes	beads
T18582	33784-33788	IN	denotes	with
T18583	33789-33791	DT	denotes	an
T18585	33792-33799	JJ	denotes	average
T18584	33800-33808	NN	denotes	diameter
T18586	33809-33811	IN	denotes	of
T18587	33812-33815	CD	denotes	150
T18588	33816-33818	NN	denotes	μm
T18589	33819-33823	VBD	denotes	were
T18581	33824-33828	VBN	denotes	used
T18590	33828-33829	.	denotes	.
T18591	33829-33996	sentence	denotes	Beads were washed twice with PBS, air dried, and loaded with 10, 20, 50, or 100 ng/μl NT-3 (Collaborative Research, Chemicon) at 4 °C overnight with constant shaking.
T18592	33830-33835	NNS	denotes	Beads
T18594	33836-33840	VBD	denotes	were
T18593	33841-33847	VBN	denotes	washed
T18595	33848-33853	RB	denotes	twice
T18596	33854-33858	IN	denotes	with
T18597	33859-33862	NN	denotes	PBS
T18598	33862-33864	,	denotes	,
T18599	33864-33867	NN	denotes	air
T18600	33868-33873	VBN	denotes	dried
T18601	33873-33875	,	denotes	,
T18602	33875-33878	CC	denotes	and
T18603	33879-33885	VBN	denotes	loaded
T18604	33886-33890	IN	denotes	with
T18605	33891-33893	CD	denotes	10
T18607	33893-33895	,	denotes	,
T18608	33895-33897	CD	denotes	20
T18609	33897-33899	,	denotes	,
T18610	33899-33901	CD	denotes	50
T18611	33901-33903	,	denotes	,
T18612	33903-33905	CC	denotes	or
T18613	33906-33909	CD	denotes	100
T18606	33910-33912	NN	denotes	ng
T18615	33912-33913	SYM	denotes	/
T18616	33913-33915	NN	denotes	μl
T18614	33916-33918	NN	denotes	NT
T18617	33918-33919	HYPH	denotes	-
T18618	33919-33920	CD	denotes	3
T18619	33921-33922	-LRB-	denotes	(
T18621	33922-33935	JJ	denotes	Collaborative
T18620	33936-33944	NN	denotes	Research
T18622	33944-33946	,	denotes	,
T18623	33946-33954	NNP	denotes	Chemicon
T18624	33954-33955	-RRB-	denotes	)
T18625	33956-33958	IN	denotes	at
T18626	33959-33960	CD	denotes	4
T18627	33961-33963	NN	denotes	°C
T18628	33964-33973	RB	denotes	overnight
T18629	33974-33978	IN	denotes	with
T18630	33979-33987	JJ	denotes	constant
T18631	33988-33995	NN	denotes	shaking
T18632	33995-33996	.	denotes	.
T18633	33996-34068	sentence	denotes	For negative control, beads were loaded with BSA (10–100 ng/μl) or PBS.
T18634	33997-34000	IN	denotes	For
T18636	34001-34009	JJ	denotes	negative
T18637	34010-34017	NN	denotes	control
T18638	34017-34019	,	denotes	,
T18639	34019-34024	NNS	denotes	beads
T18640	34025-34029	VBD	denotes	were
T18635	34030-34036	VBN	denotes	loaded
T18641	34037-34041	IN	denotes	with
T18642	34042-34045	NN	denotes	BSA
T18643	34046-34047	-LRB-	denotes	(
T18645	34047-34049	CD	denotes	10
T18647	34049-34050	HYPH	denotes	–
T18646	34050-34053	CD	denotes	100
T18644	34054-34056	NN	denotes	ng
T18648	34056-34057	SYM	denotes	/
T18649	34057-34059	NN	denotes	μl
T18650	34059-34060	-RRB-	denotes	)
T18651	34061-34063	CC	denotes	or
T18652	34064-34067	NN	denotes	PBS
T18653	34067-34068	.	denotes	.
T18654	34068-34211	sentence	denotes	Either a single neurotrophin-loaded bead or a single BSA (or PBS)–loaded bead was implanted about 200–1,200 μm away from the ganglion explant.
T18655	34069-34075	CC	denotes	Either
T18657	34076-34077	DT	denotes	a
T18658	34078-34084	JJ	denotes	single
T18659	34085-34097	NN	denotes	neurotrophin
T18661	34097-34098	HYPH	denotes	-
T18660	34098-34104	VBN	denotes	loaded
T18656	34105-34109	NN	denotes	bead
T18663	34110-34112	CC	denotes	or
T18664	34113-34114	DT	denotes	a
T18666	34115-34121	JJ	denotes	single
T18667	34122-34125	NN	denotes	BSA
T18669	34126-34127	-LRB-	denotes	(
T18670	34127-34129	CC	denotes	or
T18671	34130-34133	NN	denotes	PBS
T18672	34133-34134	-RRB-	denotes	)
T18673	34134-34135	HYPH	denotes	–
T18668	34135-34141	VBN	denotes	loaded
T18665	34142-34146	NN	denotes	bead
T18674	34147-34150	VBD	denotes	was
T18662	34151-34160	VBN	denotes	implanted
T18675	34161-34166	IN	denotes	about
T18677	34167-34170	CD	denotes	200
T18678	34170-34171	HYPH	denotes	–
T18676	34171-34176	CD	denotes	1,200
T18679	34177-34179	NN	denotes	μm
T18680	34180-34184	RB	denotes	away
T18681	34185-34189	IN	denotes	from
T18682	34190-34193	DT	denotes	the
T18684	34194-34202	NN	denotes	ganglion
T18683	34203-34210	NN	denotes	explant
T18685	34210-34211	.	denotes	.
T18686	34211-34301	sentence	denotes	Collagen-embedded cultures were then placed at 33 °C for 15 min for the matrix to harden.
T18687	34212-34220	NN	denotes	Collagen
T18689	34220-34221	HYPH	denotes	-
T18688	34221-34229	VBN	denotes	embedded
T18690	34230-34238	NNS	denotes	cultures
T18692	34239-34243	VBD	denotes	were
T18693	34244-34248	RB	denotes	then
T18691	34249-34255	VBN	denotes	placed
T18694	34256-34258	IN	denotes	at
T18695	34259-34261	CD	denotes	33
T18696	34262-34264	NN	denotes	°C
T18697	34265-34268	IN	denotes	for
T18698	34269-34271	CD	denotes	15
T18699	34272-34275	NN	denotes	min
T18700	34276-34279	IN	denotes	for
T18702	34280-34283	DT	denotes	the
T18703	34284-34290	NN	denotes	matrix
T18704	34291-34293	TO	denotes	to
T18701	34294-34300	VB	denotes	harden
T18705	34300-34301	.	denotes	.
T18706	34301-34356	sentence	denotes	Serum-free culture medium was then added to each well.
T18707	34302-34307	NN	denotes	Serum
T18709	34307-34308	HYPH	denotes	-
T18708	34308-34312	JJ	denotes	free
T18711	34313-34320	NN	denotes	culture
T18710	34321-34327	NN	denotes	medium
T18713	34328-34331	VBD	denotes	was
T18714	34332-34336	RB	denotes	then
T18712	34337-34342	VBN	denotes	added
T18715	34343-34345	IN	denotes	to
T18716	34346-34350	DT	denotes	each
T18717	34351-34355	NN	denotes	well
T18718	34355-34356	.	denotes	.
T18719	34356-34456	sentence	denotes	In cultures with WT DRG and control beads, 10% serum was added to ensure viability of the explants.
T18720	34357-34359	IN	denotes	In
T18722	34360-34368	NNS	denotes	cultures
T18723	34369-34373	IN	denotes	with
T18724	34374-34376	NN	denotes	WT
T18725	34377-34380	NN	denotes	DRG
T18726	34381-34384	CC	denotes	and
T18727	34385-34392	NN	denotes	control
T18728	34393-34398	NNS	denotes	beads
T18729	34398-34400	,	denotes	,
T18730	34400-34402	CD	denotes	10
T18731	34402-34403	NN	denotes	%
T18732	34404-34409	NN	denotes	serum
T18733	34410-34413	VBD	denotes	was
T18721	34414-34419	VBN	denotes	added
T18734	34420-34422	TO	denotes	to
T18735	34423-34429	VB	denotes	ensure
T18736	34430-34439	NN	denotes	viability
T18737	34440-34442	IN	denotes	of
T18738	34443-34446	DT	denotes	the
T18739	34447-34455	NNS	denotes	explants
T18740	34455-34456	.	denotes	.
T18741	34456-34574	sentence	denotes	TrkC-Fc (Regeneron Pharmaceuticals, Tarrytown, New York, United States) was added (20 μg/ml) into the culture medium.
T18742	34457-34461	NN	denotes	TrkC
T18744	34461-34462	HYPH	denotes	-
T18743	34462-34464	NN	denotes	Fc
T18746	34465-34466	-LRB-	denotes	(
T18748	34466-34475	NNP	denotes	Regeneron
T18747	34476-34491	NNP	denotes	Pharmaceuticals
T18749	34491-34493	,	denotes	,
T18750	34493-34502	NNP	denotes	Tarrytown
T18751	34502-34504	,	denotes	,
T18752	34504-34507	NNP	denotes	New
T18753	34508-34512	NNP	denotes	York
T18754	34512-34514	,	denotes	,
T18755	34514-34520	NNP	denotes	United
T18756	34521-34527	NNP	denotes	States
T18757	34527-34528	-RRB-	denotes	)
T18758	34529-34532	VBD	denotes	was
T18745	34533-34538	VBN	denotes	added
T18759	34539-34540	-LRB-	denotes	(
T18761	34540-34542	CD	denotes	20
T18760	34543-34545	NN	denotes	μg
T18762	34545-34546	SYM	denotes	/
T18763	34546-34548	NN	denotes	ml
T18764	34548-34549	-RRB-	denotes	)
T18765	34550-34554	IN	denotes	into
T18766	34555-34558	DT	denotes	the
T18768	34559-34566	NN	denotes	culture
T18767	34567-34573	NN	denotes	medium
T18769	34573-34574	.	denotes	.
T19117	34576-34583	NN	denotes	Explant
T19118	34584-34595	NNS	denotes	co-cultures
T19119	34595-34727	sentence	denotes	Spinal cords with attached DRGs were dissected out from Swiss Webster mouse embryos at E13, and sectioned into 300-μm-thick slices.
T19120	34596-34602	JJ	denotes	Spinal
T19121	34603-34608	NNS	denotes	cords
T19123	34609-34613	IN	denotes	with
T19124	34614-34622	VBN	denotes	attached
T19125	34623-34627	NNS	denotes	DRGs
T19126	34628-34632	VBD	denotes	were
T19122	34633-34642	VBN	denotes	dissected
T19127	34643-34646	RP	denotes	out
T19128	34647-34651	IN	denotes	from
T19129	34652-34657	NNP	denotes	Swiss
T19130	34658-34665	NNP	denotes	Webster
T19132	34666-34671	NN	denotes	mouse
T19131	34672-34679	NNS	denotes	embryos
T19133	34680-34682	IN	denotes	at
T19134	34683-34686	NN	denotes	E13
T19135	34686-34688	,	denotes	,
T19136	34688-34691	CC	denotes	and
T19137	34692-34701	VBN	denotes	sectioned
T19138	34702-34706	IN	denotes	into
T19139	34707-34710	CD	denotes	300
T19141	34710-34711	HYPH	denotes	-
T19140	34711-34713	NN	denotes	μm
T19143	34713-34714	HYPH	denotes	-
T19142	34714-34719	JJ	denotes	thick
T19144	34720-34726	NNS	denotes	slices
T19145	34726-34727	.	denotes	.
T19146	34727-34842	sentence	denotes	Tissue slices were placed on Millicell Tissue Culture Inserts (Millipore, Billrica, Massachusetts, United States).
T19147	34728-34734	NN	denotes	Tissue
T19148	34735-34741	NNS	denotes	slices
T19150	34742-34746	VBD	denotes	were
T19149	34747-34753	VBN	denotes	placed
T19151	34754-34756	IN	denotes	on
T19152	34757-34766	NN	denotes	Millicell
T19154	34767-34773	NN	denotes	Tissue
T19155	34774-34781	NN	denotes	Culture
T19153	34782-34789	NNS	denotes	Inserts
T19156	34790-34791	-LRB-	denotes	(
T19157	34791-34800	NNP	denotes	Millipore
T19158	34800-34802	,	denotes	,
T19159	34802-34810	NNP	denotes	Billrica
T19160	34810-34812	,	denotes	,
T19161	34812-34825	NNP	denotes	Massachusetts
T19162	34825-34827	,	denotes	,
T19163	34827-34833	NNP	denotes	United
T19164	34834-34840	NNP	denotes	States
T19165	34840-34841	-RRB-	denotes	)
T19166	34841-34842	.	denotes	.
T19167	34842-34987	sentence	denotes	NT-3-loaded (n = 15) or PBS-loaded (n = 6) sepharose beads were prepared as described above, and placed in the midline at mid-spinal cord level.
T19168	34843-34845	NN	denotes	NT
T19170	34845-34846	HYPH	denotes	-
T19171	34846-34847	CD	denotes	3
T19172	34847-34848	HYPH	denotes	-
T19169	34848-34854	VBN	denotes	loaded
T19174	34855-34856	-LRB-	denotes	(
T19176	34856-34857	NN	denotes	n
T19177	34858-34859	SYM	denotes	=
T19175	34860-34862	CD	denotes	15
T19178	34862-34863	-RRB-	denotes	)
T19179	34864-34866	CC	denotes	or
T19180	34867-34870	NN	denotes	PBS
T19182	34870-34871	HYPH	denotes	-
T19181	34871-34877	VBN	denotes	loaded
T19183	34878-34879	-LRB-	denotes	(
T19185	34879-34880	NN	denotes	n
T19186	34881-34882	SYM	denotes	=
T19184	34883-34884	CD	denotes	6
T19187	34884-34885	-RRB-	denotes	)
T19188	34886-34895	NN	denotes	sepharose
T19173	34896-34901	NNS	denotes	beads
T19190	34902-34906	VBD	denotes	were
T19189	34907-34915	VBN	denotes	prepared
T19191	34916-34918	IN	denotes	as
T19192	34919-34928	VBN	denotes	described
T19193	34929-34934	RB	denotes	above
T19194	34934-34936	,	denotes	,
T19195	34936-34939	CC	denotes	and
T19196	34940-34946	VBN	denotes	placed
T19197	34947-34949	IN	denotes	in
T19198	34950-34953	DT	denotes	the
T19199	34954-34961	NN	denotes	midline
T19200	34962-34964	IN	denotes	at
T19201	34965-34975	JJ	denotes	mid-spinal
T19202	34976-34980	NN	denotes	cord
T19203	34981-34986	NN	denotes	level
T19204	34986-34987	.	denotes	.
T19205	34987-35130	sentence	denotes	Inserts were placed in six-well plates with serum-free medium at the bottom of the wells, and kept at 33 °C for 3 d in the presence of 5% CO2.
T19206	34988-34995	NNS	denotes	Inserts
T19208	34996-35000	VBD	denotes	were
T19207	35001-35007	VBN	denotes	placed
T19209	35008-35010	IN	denotes	in
T19210	35011-35014	CD	denotes	six
T19212	35014-35015	HYPH	denotes	-
T19211	35015-35019	NN	denotes	well
T19213	35020-35026	NNS	denotes	plates
T19214	35027-35031	IN	denotes	with
T19215	35032-35037	NN	denotes	serum
T19217	35037-35038	HYPH	denotes	-
T19216	35038-35042	JJ	denotes	free
T19218	35043-35049	NN	denotes	medium
T19219	35050-35052	IN	denotes	at
T19220	35053-35056	DT	denotes	the
T19221	35057-35063	NN	denotes	bottom
T19222	35064-35066	IN	denotes	of
T19223	35067-35070	DT	denotes	the
T19224	35071-35076	NNS	denotes	wells
T19225	35076-35078	,	denotes	,
T19226	35078-35081	CC	denotes	and
T19227	35082-35086	VBD	denotes	kept
T19228	35087-35089	IN	denotes	at
T19229	35090-35092	CD	denotes	33
T19230	35093-35095	NN	denotes	°C
T19231	35096-35099	IN	denotes	for
T19232	35100-35101	CD	denotes	3
T19233	35102-35103	NN	denotes	d
T19234	35104-35106	IN	denotes	in
T19235	35107-35110	DT	denotes	the
T19236	35111-35119	NN	denotes	presence
T19237	35120-35122	IN	denotes	of
T19238	35123-35124	CD	denotes	5
T19239	35124-35125	NN	denotes	%
T19240	35126-35129	NN	denotes	CO2
T19241	35129-35130	.	denotes	.
T19242	35130-35241	sentence	denotes	Cultures were then fixed with 4% paraformaldehyde in PBS, and small crystals of DiI were placed into the DRGs.
T19243	35131-35139	NNS	denotes	Cultures
T19245	35140-35144	VBD	denotes	were
T19246	35145-35149	RB	denotes	then
T19244	35150-35155	VBN	denotes	fixed
T19247	35156-35160	IN	denotes	with
T19248	35161-35162	CD	denotes	4
T19249	35162-35163	NN	denotes	%
T19250	35164-35180	NN	denotes	paraformaldehyde
T19251	35181-35183	IN	denotes	in
T19252	35184-35187	NN	denotes	PBS
T19253	35187-35189	,	denotes	,
T19254	35189-35192	CC	denotes	and
T19255	35193-35198	JJ	denotes	small
T19256	35199-35207	NNS	denotes	crystals
T19258	35208-35210	IN	denotes	of
T19259	35211-35214	NN	denotes	DiI
T19260	35215-35219	VBD	denotes	were
T19257	35220-35226	VBN	denotes	placed
T19261	35227-35231	IN	denotes	into
T19262	35232-35235	DT	denotes	the
T19263	35236-35240	NNS	denotes	DRGs
T19264	35240-35241	.	denotes	.
T19265	35241-35397	sentence	denotes	Samples were incubated in a 37-°C incubator, allowing the dye to diffuse, and photographed under a Nikon (Tokyo, Japan) inverted epifluoresence microscope.
T19266	35242-35249	NNS	denotes	Samples
T19268	35250-35254	VBD	denotes	were
T19267	35255-35264	VBN	denotes	incubated
T19269	35265-35267	IN	denotes	in
T19270	35268-35269	DT	denotes	a
T19272	35270-35272	CD	denotes	37
T19274	35272-35273	HYPH	denotes	-
T19273	35273-35275	NN	denotes	°C
T19271	35276-35285	NN	denotes	incubator
T19275	35285-35287	,	denotes	,
T19276	35287-35295	VBG	denotes	allowing
T19277	35296-35299	DT	denotes	the
T19278	35300-35303	NN	denotes	dye
T19280	35304-35306	TO	denotes	to
T19279	35307-35314	VB	denotes	diffuse
T19281	35314-35316	,	denotes	,
T19282	35316-35319	CC	denotes	and
T19283	35320-35332	VBN	denotes	photographed
T19284	35333-35338	IN	denotes	under
T19285	35339-35340	DT	denotes	a
T19287	35341-35346	NNP	denotes	Nikon
T19288	35347-35348	-LRB-	denotes	(
T19289	35348-35353	NNP	denotes	Tokyo
T19290	35353-35355	,	denotes	,
T19291	35355-35360	NNP	denotes	Japan
T19292	35360-35361	-RRB-	denotes	)
T19293	35362-35370	JJ	denotes	inverted
T19294	35371-35385	NN	denotes	epifluoresence
T19286	35386-35396	NN	denotes	microscope
T19295	35396-35397	.	denotes	.
R1	T428	T423	appos	NT,"NT-3 and Proprioceptive Axon Guidance Abstract Neurotrophin"
R10	T437	T424	punct	.,required
R100	T517	T516	compound	target,muscles
R1000	T4198	T4196	prep	to,confined
R1001	T4199	T4200	amod	dorsal,cord
R1002	T4200	T4198	pobj	cord,to
R1003	T4201	T4200	amod	spinal,cord
R1004	T4202	T4200	prep	in,cord
R1005	T4203	T4204	nmod	NT,KOs
R1006	T4204	T4202	pobj	KOs,in
R1007	T4205	T4203	punct	-,NT
R1008	T4206	T4203	nummod	3,NT
R1009	T4207	T4208	punct	(,2A
R101	T518	T502	punct	.,are
R1010	T4208	T4196	parataxis	2A,confined
R1011	T4209	T4208	compound	Figure,2A
R1012	T4210	T4208	punct	),2A
R1013	T4211	T4196	punct	", ",confined
R1014	T4212	T4213	mark	as,reported
R1015	T4213	T4196	advcl	reported,confined
R1016	T4214	T4213	advmod	earlier,reported
R1017	T4215	T4196	punct	", ",confined
R1018	T4216	T4196	advcl	consistent,confined
R1019	T4217	T4216	prep	with,consistent
R102	T520	T521	advmod	Centrally,branch
R1020	T4218	T4219	det	a,absence
R1021	T4219	T4217	pobj	absence,with
R1022	T4220	T4219	amod	complete,absence
R1023	T4221	T4219	prep	of,absence
R1024	T4222	T4223	amod	proprioceptive,innervation
R1025	T4223	T4221	pobj	innervation,of
R1026	T4224	T4225	punct	(,Ernfors
R1027	T4225	T4216	meta	Ernfors,consistent
R1028	T4226	T4225	nmod	et,Ernfors
R1029	T4227	T4225	nmod	al.,Ernfors
R103	T522	T521	punct	", ",branch
R1030	T4228	T4225	nummod	1994,Ernfors
R1031	T4229	T4225	punct	;,Ernfors
R1032	T4230	T4225	nmod	Tessarollo,Ernfors
R1033	T4231	T4225	nmod	et,Ernfors
R1034	T4232	T4225	nmod	al.,Ernfors
R1035	T4233	T4225	nummod	1994,Ernfors
R1036	T4234	T4225	punct	),Ernfors
R1037	T4235	T4196	punct	.,confined
R1038	T4237	T4238	prep	In,followed
R1039	T4239	T4240	amod	double,KOs
R104	T523	T524	amod	proprioceptive,axons
R1040	T4240	T4237	pobj	KOs,In
R1041	T4241	T4238	punct	", ",followed
R1042	T4242	T4243	amod	proprioceptive,afferents
R1043	T4243	T4238	nsubj	afferents,followed
R1044	T4244	T4238	advmod	initially,followed
R1045	T4245	T4246	det	a,trajectory
R1046	T4246	T4238	dobj	trajectory,followed
R1047	T4247	T4246	amod	similar,trajectory
R1048	T4248	T4247	prep	to,similar
R1049	T4249	T4248	pobj	that,to
R105	T524	T521	nsubj	axons,branch
R1050	T4250	T4249	prep	of,that
R1051	T4251	T4252	compound	WT,counterparts
R1052	T4252	T4250	pobj	counterparts,of
R1053	T4253	T4238	punct	", ",followed
R1054	T4254	T4238	cc	but,followed
R1055	T4255	T4256	nsubj	most,failed
R1056	T4256	T4238	conj	failed,followed
R1057	T4257	T4255	prep	of,most
R1058	T4258	T4257	pobj	them,of
R1059	T4259	T4260	aux	to,project
R106	T525	T521	prep	in,branch
R1060	T4260	T4256	xcomp	project,failed
R1061	T4261	T4262	predet	all,way
R1062	T4262	T4264	npadvmod	way,to
R1063	T4263	T4262	det	the,way
R1064	T4264	T4260	prep	to,project
R1065	T4265	T4266	det	the,cord
R1066	T4266	T4264	pobj	cord,to
R1067	T4267	T4266	amod	ventral,cord
R1068	T4268	T4264	cc	and,to
R1069	T4269	T4264	conj	into,to
R107	T526	T527	amod	ectopic,regions
R1070	T4270	T4271	det	the,column
R1071	T4271	T4269	pobj	column,into
R1072	T4272	T4271	amod	lateral,column
R1073	T4273	T4271	compound	motor,column
R1074	T4274	T4256	punct	.,failed
R1075	T4276	T4277	advmod	Instead,arborized
R1076	T4277	T4280	ccomp	arborized,crossed
R1077	T4278	T4277	punct	", ",arborized
R1078	T4279	T4277	nsubj	they,arborized
R1079	T4281	T4277	prep	near,arborized
R108	T527	T525	pobj	regions,in
R1080	T4282	T4283	det	the,midline
R1081	T4283	T4281	pobj	midline,near
R1082	T4284	T4283	amod	ventral,midline
R1083	T4285	T4280	punct	;,crossed
R1084	T4286	T4280	nsubj	some,crossed
R1085	T4287	T4288	det	the,midline
R1086	T4288	T4280	dobj	midline,crossed
R1087	T4289	T4280	cc	and,crossed
R1088	T4290	T4280	conj	extended,crossed
R1089	T4291	T4290	prep	into,extended
R109	T528	T527	prep	of,regions
R1090	T4292	T4293	det	the,cord
R1091	T4293	T4291	pobj	cord,into
R1092	T4294	T4293	amod	contralateral,cord
R1093	T4295	T4293	amod	ventral,cord
R1094	T4296	T4297	punct	(,2A
R1095	T4297	T4290	parataxis	2A,extended
R1096	T4298	T4297	compound	Figure,2A
R1097	T4299	T4297	cc	and,2A
R1098	T4300	T4297	conj	2C,2A
R1099	T4301	T4297	punct	),2A
R11	T439	T440	nsubj	Deletion,rescues
R110	T529	T530	det	the,cord
R1100	T4302	T4280	punct	.,crossed
R1101	T4304	T4305	prep	In,repeated
R1102	T4306	T4304	pobj	order,In
R1103	T4307	T4308	aux	to,distinguish
R1104	T4308	T4306	acl	distinguish,order
R1105	T4309	T4308	prep	between,distinguish
R1106	T4310	T4311	det	a,role
R1107	T4311	T4309	pobj	role,between
R1108	T4312	T4311	prep	for,role
R1109	T4313	T4312	pobj	NT,for
R111	T530	T528	pobj	cord,of
R1110	T4314	T4313	punct	-,NT
R1111	T4315	T4313	nummod	3,NT
R1112	T4316	T4311	prep	in,role
R1113	T4317	T4316	pobj	initiation,in
R1114	T4318	T4317	prep	of,initiation
R1115	T4319	T4320	compound	motor,neuron
R1116	T4320	T4321	compound	neuron,innervation
R1117	T4321	T4318	pobj	innervation,of
R1118	T4322	T4311	cc	and,role
R1119	T4323	T4324	det	a,role
R112	T531	T530	amod	spinal,cord
R1120	T4324	T4311	conj	role,role
R1121	T4325	T4324	prep	for,role
R1122	T4326	T4325	pobj	maintenance,for
R1123	T4327	T4305	punct	", ",repeated
R1124	T4328	T4305	nsubj	we,repeated
R1125	T4329	T4330	det	the,labeling
R1126	T4330	T4305	dobj	labeling,repeated
R1127	T4331	T4330	compound	DiI,labeling
R1128	T4332	T4305	prep	at,repeated
R1129	T4333	T4332	pobj	E17,at
R113	T532	T521	punct	", ",branch
R1130	T4334	T4305	punct	.,repeated
R1131	T4336	T4337	compound	Innervation,patterns
R1132	T4337	T4338	nsubj	patterns,were
R1133	T4339	T4337	prep	of,patterns
R1134	T4340	T4341	nmod	E17,cords
R1135	T4341	T4339	pobj	cords,of
R1136	T4342	T4341	amod	spinal,cords
R1137	T4343	T4344	punct	(,Figure
R1138	T4344	T4337	parataxis	Figure,patterns
R1139	T4345	T4344	nummod	3,Figure
R114	T533	T534	advmod	even,crossing
R1140	T4346	T4344	punct	),Figure
R1141	T4347	T4338	acomp	similar,were
R1142	T4348	T4347	prep	to,similar
R1143	T4349	T4348	pobj	those,to
R1144	T4350	T4349	prep	at,those
R1145	T4351	T4350	pobj	P0,at
R1146	T4352	T4353	punct	(,Figure
R1147	T4353	T4349	parataxis	Figure,those
R1148	T4354	T4353	nummod	2,Figure
R1149	T4355	T4353	punct	),Figure
R115	T534	T521	advcl	crossing,branch
R1150	T4356	T4338	punct	.,were
R1151	T4358	T4359	amod	Dorsal,horns
R1152	T4359	T4360	nsubjpass	horns,filled
R1153	T4361	T4359	prep	of,horns
R1154	T4362	T4363	det	all,genotypes
R1155	T4363	T4361	pobj	genotypes,of
R1156	T4364	T4360	auxpass	were,filled
R1157	T4365	T4360	agent	with,filled
R1158	T4366	T4367	npadvmod	DiI,labeled
R1159	T4367	T4369	amod	labeled,fibers
R116	T535	T536	det	the,midline
R1160	T4368	T4367	punct	-,labeled
R1161	T4369	T4365	pobj	fibers,with
R1162	T4370	T4369	acl	corresponding,fibers
R1163	T4371	T4370	prep	to,corresponding
R1164	T4372	T4373	compound	nerve,factor
R1165	T4373	T4375	npadvmod	factor,dependent
R1166	T4374	T4373	compound	growth,factor
R1167	T4375	T4377	amod	dependent,axons
R1168	T4376	T4375	punct	–,dependent
R1169	T4377	T4371	pobj	axons,to
R117	T536	T534	dobj	midline,crossing
R1170	T4378	T4377	amod	nociceptive,axons
R1171	T4379	T4360	punct	.,filled
R1172	T4381	T4382	prep	In,extended
R1173	T4383	T4384	nmod	WT,embryos
R1174	T4384	T4381	pobj	embryos,In
R1175	T4385	T4383	cc	and,WT
R1176	T4386	T4387	compound	Bax,KO
R1177	T4387	T4383	conj	KO,WT
R1178	T4388	T4382	punct	", ",extended
R1179	T4389	T4390	amod	proprioceptive,fibers
R118	T537	T521	punct	.,branch
R1180	T4390	T4382	nsubj	fibers,extended
R1181	T4391	T4382	prep	towards,extended
R1182	T4392	T4393	amod	ventral,horn
R1183	T4393	T4394	compound	horn,neurons
R1184	T4394	T4391	pobj	neurons,towards
R1185	T4395	T4394	compound	motor,neurons
R1186	T4396	T4397	punct	(,3A
R1187	T4397	T4394	parataxis	3A,neurons
R1188	T4398	T4397	compound	Figure,3A
R1189	T4399	T4397	cc	and,3A
R119	T539	T540	advmod	In,vitro
R1190	T4400	T4397	conj	3B,3A
R1191	T4401	T4397	punct	),3A
R1192	T4402	T4382	punct	", ",extended
R1193	T4403	T4404	mark	whereas,were
R1194	T4404	T4382	advcl	were,extended
R1195	T4405	T4406	det	the,horns
R1196	T4406	T4404	nsubj	horns,were
R1197	T4407	T4406	amod	ventral,horns
R1198	T4408	T4406	prep	of,horns
R1199	T4409	T4410	det	the,embryos
R12	T441	T439	prep	of,Deletion
R120	T540	T541	amod	vitro,assays
R1200	T4410	T4408	pobj	embryos,of
R1201	T4411	T4412	nmod	NT,KO
R1202	T4412	T4410	compound	KO,embryos
R1203	T4413	T4411	punct	-,NT
R1204	T4414	T4411	nummod	3,NT
R1205	T4415	T4404	acomp	devoid,were
R1206	T4416	T4415	prep	of,devoid
R1207	T4417	T4416	pobj	innervation,of
R1208	T4418	T4419	punct	(,3C
R1209	T4419	T4404	parataxis	3C,were
R121	T541	T542	nsubj	assays,reveal
R1210	T4420	T4419	compound	Figure,3C
R1211	T4421	T4419	punct	),3C
R1212	T4422	T4382	punct	.,extended
R1213	T4424	T4425	prep	In,entered
R1214	T4426	T4427	det	the,KOs
R1215	T4427	T4424	pobj	KOs,In
R1216	T4428	T4427	nmod	Bax,KOs
R1217	T4429	T4428	punct	/,Bax
R1218	T4430	T4428	appos	NT,Bax
R1219	T4431	T4430	punct	-,NT
R122	T543	T544	compound	chemoattractant,effects
R1220	T4432	T4430	nummod	3,NT
R1221	T4433	T4427	amod	double,KOs
R1222	T4434	T4425	punct	", ",entered
R1223	T4435	T4436	npadvmod	DiI,labeled
R1224	T4436	T4438	amod	labeled,fibers
R1225	T4437	T4436	punct	-,labeled
R1226	T4438	T4425	nsubj	fibers,entered
R1227	T4439	T4440	det	the,cord
R1228	T4440	T4425	dobj	cord,entered
R1229	T4441	T4440	amod	ventral,cord
R123	T544	T542	dobj	effects,reveal
R1230	T4442	T4440	amod	spinal,cord
R1231	T4443	T4425	punct	", ",entered
R1232	T4444	T4425	cc	but,entered
R1233	T4445	T4425	conj	extended,entered
R1234	T4446	T4445	prep	towards,extended
R1235	T4447	T4448	det	the,midline
R1236	T4448	T4446	pobj	midline,towards
R1237	T4449	T4450	advmod	instead,of
R1238	T4450	T4448	cc	of,midline
R1239	T4451	T4452	det	the,horn
R124	T545	T544	prep	of,effects
R1240	T4452	T4448	conj	horn,midline
R1241	T4453	T4452	amod	ventral,horn
R1242	T4454	T4455	punct	(,3D
R1243	T4455	T4445	parataxis	3D,extended
R1244	T4456	T4455	compound	Figure,3D
R1245	T4457	T4455	punct	),3D
R1246	T4458	T4445	punct	", ",extended
R1247	T4459	T4445	prep	in,extended
R1248	T4460	T4461	det	a,pattern
R1249	T4461	T4459	pobj	pattern,in
R125	T546	T545	pobj	NT,of
R1250	T4542	T4543	det	the,absence
R1251	T4462	T4461	amod	similar,pattern
R1252	T4543	T4541	pobj	absence,in
R1253	T4463	T4462	prep	to,similar
R1254	T4544	T4543	prep	of,absence
R1255	T4545	T4544	pobj	NT,of
R1256	T4546	T4545	punct	-,NT
R1257	T4464	T4463	pobj	that,to
R1258	T4547	T4545	nummod	3,NT
R1259	T4548	T4549	det	a,requirement
R126	T547	T546	punct	-,NT
R1260	T4465	T4464	acl	observed,that
R1261	T4549	T4531	dobj	requirement,suggests
R1262	T4550	T4549	prep	for,requirement
R1263	T4551	T4550	pobj	NT,for
R1264	T4466	T4465	prep	at,observed
R1265	T4552	T4551	punct	-,NT
R1266	T4553	T4551	nummod	3,NT
R1267	T4467	T4466	pobj	P0,at
R1268	T4554	T4549	prep	for,requirement
R1269	T4555	T4556	amod	proper,axon
R127	T548	T546	nummod	3,NT
R1270	T4468	T4425	punct	.,entered
R1271	T4556	T4554	pobj	axon,for
R1272	T4557	T4556	amod	targeting,axon
R1273	T4470	T4471	poss	Our,data
R1274	T4558	T4549	prep	in,requirement
R1275	T4559	T4558	pobj	addition,in
R1276	T4560	T4559	prep	to,addition
R1277	T4561	T4562	det	a,role
R1278	T4471	T4472	nsubj	data,point
R1279	T4562	T4560	pobj	role,to
R128	T549	T544	prep	on,effects
R1280	T4563	T4562	prep	in,role
R1281	T4473	T4472	prep	to,point
R1282	T4564	T4565	amod	sensory,axon
R1283	T4565	T4566	compound	axon,maintenance
R1284	T4566	T4563	pobj	maintenance,in
R1285	T4474	T4475	det	a,absence
R1286	T4567	T4531	punct	.,suggests
R1287	T4475	T4473	pobj	absence,to
R1288	T4476	T4475	amod	complete,absence
R1289	T4477	T4475	prep	of,absence
R129	T550	T551	amod	dorsal,root
R1290	T4478	T4479	amod	proprioceptive,innervation
R1291	T4479	T4477	pobj	innervation,of
R1292	T4480	T4479	prep	of,innervation
R1293	T4481	T4482	det	the,horn
R1294	T4482	T4480	pobj	horn,of
R1295	T4483	T4482	amod	ventral,horn
R1296	T4484	T4482	prep	of,horn
R1297	T4485	T4486	det	the,cord
R1298	T4486	T4484	pobj	cord,of
R1299	T4487	T4488	npadvmod	Bax,null
R13	T442	T443	det	the,gene
R130	T551	T552	compound	root,ganglion
R1300	T4488	T4486	amod	null,cord
R1301	T4489	T4487	punct	/,Bax
R1302	T4490	T4487	appos	NT,Bax
R1303	T4491	T4490	punct	-,NT
R1304	T4492	T4490	nummod	3,NT
R1305	T4493	T4486	amod	spinal,cord
R1306	T4494	T4475	prep	throughout,absence
R1307	T4495	T4496	det	the,stages
R1308	T4496	T4494	pobj	stages,throughout
R1309	T4497	T4496	amod	developmental,stages
R131	T552	T553	compound	ganglion,axons
R1310	T4498	T4496	acl	investigated,stages
R1311	T4499	T4472	punct	.,point
R1312	T4501	T4502	mark	As,reach
R1313	T4502	T4507	advcl	reach,established
R1314	T4503	T4504	det	the,axons
R1315	T4504	T4502	nsubj	axons,reach
R1316	T4505	T4504	amod	sensory,axons
R1317	T4506	T4502	neg	never,reach
R1318	T4508	T4509	compound	motor,neuron
R1319	T4509	T4510	compound	neuron,dendrites
R132	T553	T549	pobj	axons,on
R1320	T4510	T4502	dobj	dendrites,reach
R1321	T4511	T4510	prep	in,dendrites
R1322	T4512	T4513	det	the,horn
R1323	T4513	T4511	pobj	horn,in
R1324	T4514	T4513	amod	ventral,horn
R1325	T4515	T4516	punct	(,S1
R1326	T4516	T4502	parataxis	S1,reach
R1327	T4517	T4516	compound	Figure,S1
R1328	T4518	T4516	punct	),S1
R1329	T4519	T4507	punct	", ",established
R133	T554	T542	punct	.,reveal
R1330	T4520	T4521	det	the,circuit
R1331	T4521	T4507	nsubjpass	circuit,established
R1332	T4522	T4523	compound	stretch,reflex
R1333	T4523	T4521	compound	reflex,circuit
R1334	T4524	T4521	compound	arc,circuit
R1335	T4525	T4507	auxpass	is,established
R1336	T4526	T4507	neg	not,established
R1337	T4527	T4507	punct	.,established
R1338	T4529	T4530	det	The,failure
R1339	T4530	T4531	nsubj	failure,suggests
R134	T556	T557	poss	Our,results
R1340	T4532	T4533	aux	to,initiate
R1341	T4533	T4530	acl	initiate,failure
R1342	T4534	T4533	dobj	contact,initiate
R1343	T4535	T4534	prep	between,contact
R1344	T4536	T4537	amod	sensory,axons
R1345	T4537	T4535	pobj	axons,between
R1346	T4538	T4537	cc	and,axons
R1347	T4539	T4540	compound	motor,neurons
R1348	T4540	T4537	conj	neurons,axons
R1349	T4541	T4533	prep	in,initiate
R135	T557	T558	nsubj	results,show
R1352	T5932	T5933	nsubjpass	NT,Required
R1353	T5934	T5932	punct	-,NT
R1354	T5935	T5932	nummod	3,NT
R1355	T5936	T5933	auxpass	Is,Required
R1356	T5937	T5933	prep	for,Required
R1357	T5938	T5939	amod	Proper,Innervation
R1358	T5939	T5937	pobj	Innervation,for
R1359	T5940	T5939	amod	Peripheral,Innervation
R136	T559	T560	mark	that,acts
R1360	T5942	T5943	prep	In,investigated
R1361	T5944	T5942	pobj	order,In
R1362	T5945	T5946	aux	to,study
R1363	T5946	T5944	acl	study,order
R1364	T5947	T5948	amod	peripheral,innervation
R1365	T5948	T5946	dobj	innervation,study
R1366	T5949	T5946	prep	in,study
R1367	T5950	T5951	amod	double,KO
R1368	T5951	T5952	compound	KO,animals
R1369	T5952	T5949	pobj	animals,in
R137	T560	T558	ccomp	acts,show
R1370	T5953	T5943	punct	", ",investigated
R1371	T5954	T5943	nsubj	we,investigated
R1372	T5955	T5956	compound	spindle,development
R1373	T5956	T5943	dobj	development,investigated
R1374	T5957	T5956	prep	in,development
R1375	T5958	T5959	det	the,muscle
R1376	T5959	T5957	pobj	muscle,in
R1377	T5960	T5959	compound	gastrocnemius,muscle
R1378	T5961	T5943	punct	.,investigated
R1379	T5963	T5964	compound	Muscle,spindles
R138	T561	T562	compound	survival,factor
R1380	T5964	T5965	nsubjpass	spindles,identified
R1381	T5966	T5965	aux	could,identified
R1382	T5967	T5965	auxpass	be,identified
R1383	T5968	T5965	advmod	easily,identified
R1384	T5969	T5965	prep	in,identified
R1385	T5970	T5971	nmod	P0,animals
R1386	T5971	T5969	pobj	animals,in
R1387	T5972	T5971	nmod	WT,animals
R1388	T5973	T5972	cc	and,WT
R1389	T5974	T5975	compound	Bax,KO
R139	T562	T563	compound	factor,NT
R1390	T5975	T5972	conj	KO,WT
R1391	T5976	T5965	prep	by,identified
R1392	T5977	T5978	poss	their,morphology
R1393	T5978	T5976	pobj	morphology,by
R1394	T5979	T5978	amod	characteristic,morphology
R1395	T5980	T5981	punct	(,4A
R1396	T5981	T5965	parataxis	4A,identified
R1397	T5982	T5981	compound	Figure,4A
R1398	T5983	T5981	cc	and,4A
R1399	T5984	T5981	conj	4B,4A
R14	T443	T441	pobj	gene,of
R140	T563	T560	nsubj	NT,acts
R1400	T5985	T5981	punct	),4A
R1401	T5986	T5965	punct	.,identified
R1402	T5988	T5989	amod	Proprioceptive,fibers
R1403	T5989	T5990	nsubj	fibers,formed
R1404	T5991	T5989	acl	labeled,fibers
R1405	T5992	T5991	prep	with,labeled
R1406	T5993	T5994	nmod	neurofilament,M
R1407	T5994	T5996	nmod	M,antibody
R1408	T5995	T5994	punct	-,M
R1409	T5996	T5992	pobj	antibody,with
R141	T564	T563	punct	-,NT
R1410	T5997	T5994	punct	(,M
R1411	T5998	T5999	compound	NF,M
R1412	T5999	T5994	appos	M,M
R1413	T6000	T5999	punct	-,M
R1414	T6001	T5996	punct	),antibody
R1415	T6002	T6003	npadvmod	ring,like
R1416	T6003	T6005	amod	like,endings
R1417	T6004	T6003	punct	-,like
R1418	T6005	T5990	dobj	endings,formed
R1419	T6006	T6005	amod	spiral,endings
R142	T565	T563	nummod	3,NT
R1420	T6007	T6005	acl	wrapped,endings
R1421	T6008	T6007	prep	around,wrapped
R1422	T6009	T6010	amod	intrafusal,fibers
R1423	T6010	T6008	pobj	fibers,around
R1424	T6011	T6010	compound	bag,fibers
R1425	T6012	T6010	acl	labeled,fibers
R1426	T6013	T6012	prep	with,labeled
R1427	T6014	T6015	compound	S46,antibody
R1428	T6015	T6013	pobj	antibody,with
R1429	T6016	T6015	punct	", ",antibody
R143	T566	T560	prep	as,acts
R1430	T6017	T6015	amod	specific,antibody
R1431	T6018	T6017	prep	for,specific
R1432	T6019	T6020	amod	slow,developmental
R1433	T6020	T6021	amod	developmental,protein
R1434	T6021	T6018	pobj	protein,for
R1435	T6022	T6021	nmod	myosin,protein
R1436	T6023	T6024	amod	heavy,chain
R1437	T6024	T6021	compound	chain,protein
R1438	T6025	T6026	punct	(,Miller
R1439	T6026	T5990	meta	Miller,formed
R144	T567	T568	det	a,molecule
R1440	T6027	T6026	nmod	et,Miller
R1441	T6028	T6026	nmod	al.,Miller
R1442	T6029	T6026	nummod	1985,Miller
R1443	T6030	T6026	punct	),Miller
R1444	T6031	T5990	punct	.,formed
R1445	T6033	T6034	mark	As,reported
R1446	T6034	T6035	advcl	reported,were
R1447	T6036	T6034	advmod	earlier,reported
R1448	T6037	T6035	punct	", ",were
R1449	T6038	T6035	expl	there,were
R145	T568	T566	pobj	molecule,as
R1450	T6039	T6040	det	no,spindles
R1451	T6040	T6035	attr	spindles,were
R1452	T6041	T6040	compound	muscle,spindles
R1453	T6042	T6035	prep	in,were
R1454	T6043	T6044	nmod	NT,KO
R1455	T6044	T6047	compound	KO,animals
R1456	T6045	T6043	punct	-,NT
R1457	T6046	T6043	nummod	3,NT
R1458	T6047	T6042	pobj	animals,in
R1459	T6048	T6049	punct	(,Ernfors
R146	T569	T570	amod	short,distance
R1460	T6049	T6035	meta	Ernfors,were
R1461	T6050	T6049	nmod	et,Ernfors
R1462	T6051	T6049	nmod	al.,Ernfors
R1463	T6052	T6049	nummod	1994,Ernfors
R1464	T6053	T6049	punct	),Ernfors
R1465	T6054	T6035	punct	.,were
R1466	T6056	T6057	prep	On,had
R1467	T6058	T6059	det	the,hand
R1468	T6059	T6056	pobj	hand,On
R1469	T6060	T6059	amod	other,hand
R147	T570	T568	compound	distance,molecule
R1470	T6061	T6057	punct	", ",had
R1471	T6062	T6063	compound	Bax,KO
R1472	T6063	T6064	compound	KO,animals
R1473	T6064	T6057	nsubj	animals,had
R1474	T6065	T6066	amod	more,spindles
R1475	T6066	T6057	dobj	spindles,had
R1476	T6067	T6068	mark	than,WT
R1477	T6068	T6066	advcl	WT,spindles
R1478	T6069	T6057	punct	", ",had
R1479	T6070	T6057	cc	and,had
R148	T571	T570	punct	-,distance
R1480	T6071	T6072	nsubj	spindles,were
R1481	T6072	T6057	conj	were,had
R1482	T6073	T6072	prep	in,were
R1483	T6074	T6073	pobj	clusters,in
R1484	T6075	T6072	advcl	similar,were
R1485	T6076	T6075	prep	to,similar
R1486	T6077	T6076	pobj	animals,to
R1487	T6078	T6077	acl	over-expressing,animals
R1488	T6079	T6078	dobj	NT,over-expressing
R1489	T6080	T6079	punct	-,NT
R149	T572	T573	compound	axon,guidance
R1490	T6081	T6079	nummod	3,NT
R1491	T6082	T6078	prep	in,over-expressing
R1492	T6083	T6084	det	the,muscle
R1493	T6084	T6082	pobj	muscle,in
R1494	T6085	T6086	punct	(,Wright
R1495	T6086	T6072	meta	Wright,were
R1496	T6087	T6086	nmod	et,Wright
R1497	T6088	T6086	nmod	al.,Wright
R1498	T6089	T6086	nummod	1997,Wright
R1499	T6090	T6086	punct	),Wright
R15	T444	T443	amod	proapoptotic,gene
R150	T573	T568	compound	guidance,molecule
R1500	T6091	T6072	punct	.,were
R1501	T6093	T6094	mark	Although,rescued
R1502	T6094	T6102	advcl	rescued,detected
R1503	T6095	T6096	npadvmod	NT,dependent
R1504	T6096	T6100	amod	dependent,cells
R1505	T6097	T6095	punct	-,NT
R1506	T6098	T6095	nummod	3,NT
R1507	T6099	T6096	punct	-,dependent
R1508	T6100	T6094	nsubjpass	cells,rescued
R1509	T6101	T6094	auxpass	were,rescued
R151	T574	T560	prep	for,acts
R1510	T6103	T6102	punct	", ",detected
R1511	T6104	T6105	det	no,spindles
R1512	T6105	T6102	nsubjpass	spindles,detected
R1513	T6106	T6105	compound	muscle,spindles
R1514	T6107	T6102	auxpass	were,detected
R1515	T6108	T6102	prep	in,detected
R1516	T6109	T6110	det	the,limbs
R1517	T6110	T6108	pobj	limbs,in
R1518	T6111	T6110	prep	of,limbs
R1519	T6112	T6113	amod	double,KOs
R152	T575	T576	compound	muscle,afferents
R1520	T6113	T6111	pobj	KOs,of
R1521	T6114	T6115	punct	(,4A
R1522	T6115	T6102	parataxis	4A,detected
R1523	T6116	T6115	compound	Figure,4A
R1524	T6117	T6115	cc	and,4A
R1525	T6118	T6115	conj	4B,4A
R1526	T6119	T6115	punct	),4A
R1527	T6120	T6102	punct	.,detected
R1528	T6122	T6123	compound	Muscle,spindles
R1529	T6123	T6124	nsubjpass	spindles,observed
R153	T576	T574	pobj	afferents,for
R1530	T6125	T6124	aux	could,observed
R1531	T6126	T6124	auxpass	be,observed
R1532	T6127	T6124	prep	with,observed
R1533	T6128	T6129	compound	TrkC,antibody
R1534	T6129	T6127	pobj	antibody,with
R1535	T6130	T6124	prep	in,observed
R1536	T6131	T6132	nmod	WT,animals
R1537	T6132	T6130	pobj	animals,in
R1538	T6133	T6131	cc	and,WT
R1539	T6134	T6135	compound	Bax,KO
R154	T577	T576	compound	sensory,afferents
R1540	T6135	T6131	conj	KO,WT
R1541	T6136	T6130	punct	", ",in
R1542	T6137	T6130	cc	but,in
R1543	T6138	T6137	neg	not,but
R1544	T6139	T6130	conj	in,in
R1545	T6140	T6141	nmod	NT,KOs
R1546	T6141	T6139	pobj	KOs,in
R1547	T6142	T6140	punct	-,NT
R1548	T6143	T6140	nummod	3,NT
R1549	T6144	T6140	cc	or,NT
R155	T578	T579	mark	as,approach
R1550	T6145	T6140	conj	double,NT
R1551	T6146	T6147	punct	(,4E
R1552	T6147	T6124	parataxis	4E,observed
R1553	T6148	T6147	compound	Figure,4E
R1554	T6149	T6147	punct	),4E
R1555	T6150	T6124	punct	.,observed
R1556	T6152	T6153	prep	In,detected
R1557	T6153	T6171	ccomp	detected,were
R1558	T6154	T6155	preconj	both,NT
R1559	T6155	T6156	nmod	NT,KO
R156	T579	T560	advcl	approach,acts
R1560	T6156	T6161	compound	KO,animals
R1561	T6157	T6155	punct	-,NT
R1562	T6158	T6155	nummod	3,NT
R1563	T6159	T6155	cc	and,NT
R1564	T6160	T6155	conj	double,NT
R1565	T6161	T6152	pobj	animals,In
R1566	T6162	T6153	punct	", ",detected
R1567	T6163	T6164	compound	NF,M
R1568	T6164	T6166	npadvmod	M,labeled
R1569	T6165	T6164	punct	-,M
R157	T580	T579	nsubj	they,approach
R1570	T6166	T6168	amod	labeled,fibers
R1571	T6167	T6166	punct	-,labeled
R1572	T6168	T6153	nsubjpass	fibers,detected
R1573	T6169	T6153	aux	could,detected
R1574	T6170	T6153	auxpass	be,detected
R1575	T6172	T6153	prep	in,detected
R1576	T6173	T6172	pobj	muscles,in
R1577	T6174	T6171	punct	", ",were
R1578	T6175	T6171	advmod	thus,were
R1579	T6176	T6177	det	the,muscles
R158	T581	T582	poss	their,targets
R1580	T6177	T6171	nsubj	muscles,were
R1581	T6178	T6177	prep	of,muscles
R1582	T6179	T6180	det	these,animals
R1583	T6180	T6178	pobj	animals,of
R1584	T6181	T6171	neg	not,were
R1585	T6182	T6183	advmod	completely,devoid
R1586	T6183	T6171	acomp	devoid,were
R1587	T6184	T6183	prep	of,devoid
R1588	T6185	T6186	compound	nerve,fibers
R1589	T6186	T6184	pobj	fibers,of
R159	T582	T579	dobj	targets,approach
R1590	T6187	T6171	punct	.,were
R1591	T6189	T6190	mark	Since,were
R1592	T6190	T6192	advcl	were,think
R1593	T6191	T6190	expl	there,were
R1594	T6193	T6194	det	no,fibers
R1595	T6194	T6190	attr	fibers,were
R1596	T6195	T6194	nmod	TrkC,fibers
R1597	T6196	T6195	punct	-,TrkC
R1598	T6197	T6195	amod	positive,TrkC
R1599	T6198	T6190	prep	in,were
R16	T445	T443	appos	Bax,gene
R160	T583	T582	amod	proper,targets
R1600	T6199	T6200	det	these,muscles
R1601	T6200	T6198	pobj	muscles,in
R1602	T6201	T6192	punct	", ",think
R1603	T6202	T6192	nsubj	we,think
R1604	T6203	T6204	mark	that,correspond
R1605	T6204	T6192	ccomp	correspond,think
R1606	T6205	T6206	det	these,fibers
R1607	T6206	T6204	nsubj	fibers,correspond
R1608	T6207	T6208	compound	NF,M
R1609	T6208	T6210	npadvmod	M,labeled
R161	T584	T558	punct	.,show
R1610	T6209	T6208	punct	-,M
R1611	T6210	T6206	amod	labeled,fibers
R1612	T6211	T6210	punct	-,labeled
R1613	T6212	T6204	prep	to,correspond
R1614	T6213	T6214	compound	motor,axons
R1615	T6214	T6212	pobj	axons,to
R1616	T6215	T6192	punct	.,think
R1617	T6217	T6218	nsubj	Absence,be
R1618	T6219	T6217	prep	of,Absence
R1619	T6220	T6221	compound	muscle,spindles
R162	T1178	T1179	nsubj	Neurotrophin,is
R1620	T6221	T6219	pobj	spindles,of
R1621	T6222	T6218	aux	might,be
R1622	T6223	T6218	prep	due,be
R1623	T6224	T6223	pcomp	to,due
R1624	T6225	T6226	det	a,failure
R1625	T6226	T6223	pobj	failure,due
R1626	T6227	T6226	prep	in,failure
R1627	T6228	T6227	pobj	initiation,in
R1628	T6229	T6228	prep	of,initiation
R1629	T6230	T6229	pobj	differentiation,of
R163	T1180	T1178	punct	-,Neurotrophin
R1630	T6231	T6228	prep	by,initiation
R1631	T6232	T6233	amod	proprioceptive,axons
R1632	T6233	T6231	pobj	axons,by
R1633	T6234	T6226	punct	", ",failure
R1634	T6235	T6226	cc	or,failure
R1635	T6236	T6237	det	a,failure
R1636	T6237	T6226	conj	failure,failure
R1637	T6238	T6237	prep	of,failure
R1638	T6239	T6238	pobj	maturation,of
R1639	T6240	T6239	cc	and,maturation
R164	T1181	T1178	nummod	3,Neurotrophin
R1640	T6241	T6239	conj	maintenance,maturation
R1641	T6242	T6239	prep	in,maturation
R1642	T6243	T6244	det	the,absence
R1643	T6244	T6242	pobj	absence,in
R1644	T6245	T6244	prep	of,absence
R1645	T6246	T6245	pobj	NT,of
R1646	T6247	T6246	punct	-,NT
R1647	T6248	T6246	nummod	3,NT
R1648	T6249	T6218	punct	.,be
R1649	T6251	T6252	aux	To,distinguish
R165	T1182	T1178	punct	(,Neurotrophin
R1650	T6252	T6253	advcl	distinguish,investigated
R1651	T6254	T6252	prep	between,distinguish
R1652	T6255	T6256	det	these,possibilities
R1653	T6256	T6254	pobj	possibilities,between
R1654	T6257	T6256	nummod	two,possibilities
R1655	T6258	T6253	punct	", ",investigated
R1656	T6259	T6253	nsubj	we,investigated
R1657	T6260	T6261	compound	muscle,spindle
R1658	T6261	T6262	compound	spindle,development
R1659	T6262	T6253	dobj	development,investigated
R166	T1183	T1178	appos	NT,Neurotrophin
R1660	T6263	T6253	prep	at,investigated
R1661	T6264	T6263	pobj	E15,at
R1662	T6265	T6264	cc	and,E15
R1663	T6266	T6264	conj	E17,E15
R1664	T6267	T6253	prep	with,investigated
R1665	T6268	T6269	nmod	S46,immunostaining
R1666	T6269	T6267	pobj	immunostaining,with
R1667	T6270	T6268	punct	/,S46
R1668	T6271	T6272	compound	NF,M
R1669	T6272	T6268	appos	M,S46
R167	T1184	T1183	punct	-,NT
R1670	T6273	T6272	punct	-,M
R1671	T6274	T6275	advmod	as,as
R1672	T6275	T6269	cc	as,immunostaining
R1673	T6276	T6275	advmod	well,as
R1674	T6277	T6278	compound	DiI,labeling
R1675	T6278	T6269	conj	labeling,immunostaining
R1676	T6279	T6253	punct	.,investigated
R1677	T6281	T6282	det	No,structures
R1678	T6282	T6283	nsubjpass	structures,detected
R1679	T6284	T6282	prep	with,structures
R168	T1185	T1183	nummod	3,NT
R1680	T6285	T6286	det	the,shape
R1681	T6286	T6284	pobj	shape,with
R1682	T6287	T6286	amod	characteristic,shape
R1683	T6288	T6289	compound	muscle,spindle
R1684	T6289	T6286	compound	spindle,shape
R1685	T6290	T6283	aux	could,detected
R1686	T6291	T6283	auxpass	be,detected
R1687	T6292	T6283	prep	in,detected
R1688	T6293	T6292	pobj	any,in
R1689	T6294	T6293	prep	of,any
R169	T1186	T1179	punct	),is
R1690	T6295	T6296	det	the,genotypes
R1691	T6296	T6294	pobj	genotypes,of
R1692	T6297	T6283	prep	at,detected
R1693	T6298	T6297	pobj	E15,at
R1694	T6299	T6300	punct	(,S2
R1695	T6300	T6283	parataxis	S2,detected
R1696	T6301	T6300	compound	Figure,S2
R1697	T6302	T6300	punct	),S2
R1698	T6303	T6283	punct	.,detected
R1699	T6305	T6306	advmod	However,identified
R17	T446	T439	prep	in,Deletion
R170	T1187	T1188	det	a,requirement
R1700	T6307	T6306	punct	", ",identified
R1701	T6308	T6309	amod	numerous,spindles
R1702	T6309	T6306	nsubjpass	spindles,identified
R1703	T6310	T6309	amod	developing,spindles
R1704	T6311	T6306	aux	could,identified
R1705	T6312	T6306	auxpass	be,identified
R1706	T6313	T6306	prep	at,identified
R1707	T6314	T6313	pobj	E17,at
R1708	T6315	T6306	prep	in,identified
R1709	T6316	T6315	pobj	WT,in
R171	T1188	T1179	attr	requirement,is
R1710	T6317	T6316	cc	and,WT
R1711	T6318	T6319	compound	Bax,KOs
R1712	T6319	T6316	conj	KOs,WT
R1713	T6320	T6315	punct	", ",in
R1714	T6321	T6315	cc	but,in
R1715	T6322	T6321	neg	not,but
R1716	T6323	T6315	conj	in,in
R1717	T6324	T6325	nmod	NT,KO
R1718	T6325	T6328	compound	KO,embryos
R1719	T6326	T6324	punct	-,NT
R172	T1189	T1188	amod	key,requirement
R1720	T6327	T6324	nummod	3,NT
R1721	T6328	T6323	pobj	embryos,in
R1722	T6329	T6330	punct	(,4C
R1723	T6330	T6306	parataxis	4C,identified
R1724	T6331	T6330	compound	Figure,4C
R1725	T6332	T6330	punct	),4C
R1726	T6333	T6306	punct	.,identified
R1727	T6335	T6336	npadvmod	Bax,null
R1728	T6336	T6342	amod	null,muscles
R1729	T6337	T6335	punct	/,Bax
R173	T1190	T1188	prep	for,requirement
R1730	T6338	T6335	appos	NT,Bax
R1731	T6339	T6338	punct	-,NT
R1732	T6340	T6338	nummod	3,NT
R1733	T6341	T6336	amod	double,null
R1734	T6342	T6343	nsubj	muscles,were
R1735	T6344	T6343	acomp	devoid,were
R1736	T6345	T6344	prep	of,devoid
R1737	T6346	T6345	pobj	spindles,of
R1738	T6347	T6348	punct	(,4C
R1739	T6348	T6344	parataxis	4C,devoid
R174	T1191	T1192	det	the,development
R1740	T6349	T6348	compound	Figure,4C
R1741	T6350	T6348	punct	),4C
R1742	T6351	T6343	punct	", ",were
R1743	T6352	T6343	prep	except,were
R1744	T6353	T6352	prep	for,except
R1745	T6354	T6355	nummod	one,structure
R1746	T6355	T6353	pobj	structure,for
R1747	T6356	T6357	npadvmod	spindle,like
R1748	T6357	T6355	amod	like,structure
R1749	T6358	T6357	punct	-,like
R175	T1192	T1190	pobj	development,for
R1750	T6359	T6355	acl	observed,structure
R1751	T6360	T6359	prep	in,observed
R1752	T6361	T6362	nummod	one,leg
R1753	T6362	T6360	pobj	leg,in
R1754	T6363	T6362	prep	of,leg
R1755	T6364	T6365	det	an,embryo
R1756	T6365	T6363	pobj	embryo,of
R1757	T6366	T6367	punct	(,denoted
R1758	T6367	T6343	parataxis	denoted,were
R1759	T6368	T6369	compound	Figure,4C
R176	T1193	T1192	prep	of,development
R1760	T6369	T6367	dep	4C,denoted
R1761	T6370	T6367	punct	", ",denoted
R1762	T6371	T6367	dep	inset,denoted
R1763	T6372	T6367	punct	", ",denoted
R1764	T6373	T6367	prep	by,denoted
R1765	T6374	T6375	det	the,asterisk
R1766	T6375	T6373	pobj	asterisk,by
R1767	T6376	T6367	punct	),denoted
R1768	T6377	T6343	punct	.,were
R1769	T6379	T6380	compound	DiI,labeling
R177	T1194	T1195	amod	proprioceptive,inputs
R1770	T6380	T6381	nsubj	labeling,yielded
R1771	T6382	T6380	prep	through,labeling
R1772	T6383	T6384	det	the,DRGs
R1773	T6384	T6382	pobj	DRGs,through
R1774	T6385	T6380	prep	at,labeling
R1775	T6386	T6385	pobj	E17,at
R1776	T6387	T6388	amod	similar,results
R1777	T6388	T6381	dobj	results,yielded
R1778	T6389	T6381	punct	", ",yielded
R1779	T6390	T6391	mark	with,identified
R178	T1195	T1193	pobj	inputs,of
R1780	T6391	T6381	advcl	identified,yielded
R1781	T6392	T6393	compound	muscle,spindles
R1782	T6393	T6391	nsubj	spindles,identified
R1783	T6394	T6391	prep	in,identified
R1784	T6395	T6396	amod	parallel,sections
R1785	T6396	T6394	pobj	sections,in
R1786	T6397	T6396	prep	in,sections
R1787	T6398	T6399	nmod	WT,muscles
R1788	T6399	T6397	pobj	muscles,in
R1789	T6400	T6398	cc	and,WT
R179	T1196	T1195	prep	to,inputs
R1790	T6401	T6402	npadvmod	Bax,null
R1791	T6402	T6398	conj	null,WT
R1792	T6403	T6404	punct	(,4D
R1793	T6404	T6396	parataxis	4D,sections
R1794	T6405	T6404	compound	Figure,4D
R1795	T6406	T6404	punct	),4D
R1796	T6407	T6394	punct	", ",in
R1797	T6408	T6394	cc	but,in
R1798	T6409	T6408	neg	not,but
R1799	T6410	T6394	conj	in,in
R18	T447	T448	nmod	NT,knockout
R180	T1197	T1198	amod	motor,neurons
R1800	T6411	T6412	nmod	NT,KO
R1801	T6412	T6417	compound	KO,animals
R1802	T6413	T6411	punct	-,NT
R1803	T6414	T6411	nummod	3,NT
R1804	T6415	T6411	cc	or,NT
R1805	T6416	T6411	conj	double,NT
R1806	T6417	T6410	pobj	animals,in
R1807	T6418	T6381	punct	.,yielded
R1808	T6420	T6421	mark	Although,detected
R1809	T6421	T6428	advcl	detected,formed
R181	T1198	T1196	pobj	neurons,to
R1810	T6422	T6423	npadvmod	DiI,labeled
R1811	T6423	T6425	amod	labeled,fibers
R1812	T6424	T6423	punct	-,labeled
R1813	T6425	T6421	nsubjpass	fibers,detected
R1814	T6426	T6421	aux	could,detected
R1815	T6427	T6421	auxpass	be,detected
R1816	T6429	T6421	prep	in,detected
R1817	T6430	T6431	amod	double,null
R1818	T6431	T6432	amod	null,muscles
R1819	T6432	T6429	pobj	muscles,in
R182	T1199	T1200	punct	(,Chen
R1820	T6433	T6428	punct	", ",formed
R1821	T6434	T6428	nsubj	they,formed
R1822	T6435	T6428	neg	never,formed
R1823	T6436	T6437	npadvmod	ring,like
R1824	T6437	T6439	amod	like,structures
R1825	T6438	T6437	punct	-,like
R1826	T6439	T6428	dobj	structures,formed
R1827	T6440	T6439	amod	characteristic,structures
R1828	T6441	T6440	prep	of,characteristic
R1829	T6442	T6443	compound	muscle,spindles
R183	T1200	T1179	meta	Chen,is
R1830	T6443	T6441	pobj	spindles,of
R1831	T6444	T6428	punct	.,formed
R1832	T6446	T6447	nsubj	We,examined
R1833	T6448	T6447	advmod	also,examined
R1834	T6449	T6450	compound	TrkA,TrkC
R1835	T6450	T6452	compound	TrkC,expression
R1836	T6451	T6450	punct	/,TrkC
R1837	T6452	T6447	dobj	expression,examined
R1838	T6453	T6447	prep	at,examined
R1839	T6454	T6453	pobj	P0,at
R184	T1201	T1200	cc	and,Chen
R1840	T6455	T6447	prep	in,examined
R1841	T6456	T6457	det	the,nerve
R1842	T6457	T6455	pobj	nerve,in
R1843	T6458	T6457	amod	tibial,nerve
R1844	T6459	T6457	punct	", ",nerve
R1845	T6460	T6461	dep	which,carries
R1846	T6461	T6457	relcl	carries,nerve
R1847	T6462	T6463	amod	sensory,fibers
R1848	T6463	T6461	dobj	fibers,carries
R1849	T6464	T6461	prep	to,carries
R185	T1202	T1200	conj	Frank,Chen
R1850	T6465	T6466	det	the,muscle
R1851	T6466	T6464	pobj	muscle,to
R1852	T6467	T6466	compound	gastrocnemius,muscle
R1853	T6468	T6469	advmod	as,as
R1854	T6469	T6466	cc	as,muscle
R1855	T6470	T6469	advmod	well,as
R1856	T6471	T6472	det	the,skin
R1857	T6472	T6466	conj	skin,muscle
R1858	T6473	T6472	prep	of,skin
R1859	T6474	T6475	det	the,leg
R186	T1203	T1202	nummod	1999,Frank
R1860	T6475	T6473	pobj	leg,of
R1861	T6476	T6475	amod	lower,leg
R1862	T6477	T6447	punct	.,examined
R1863	T6479	T6480	prep	In,seen
R1864	T6480	T6492	ccomp	seen,are
R1865	T6481	T6482	nmod	NT,KOs
R1866	T6482	T6479	pobj	KOs,In
R1867	T6483	T6481	punct	-,NT
R1868	T6484	T6481	nummod	3,NT
R1869	T6485	T6480	punct	", ",seen
R187	T1204	T1202	punct	;,Frank
R1870	T6486	T6487	npadvmod	TrkA,positive
R1871	T6487	T6489	amod	positive,axons
R1872	T6488	T6487	punct	-,positive
R1873	T6489	T6480	nsubjpass	axons,seen
R1874	T6490	T6480	aux	could,seen
R1875	T6491	T6480	auxpass	be,seen
R1876	T6493	T6480	prep	in,seen
R1877	T6494	T6495	det	the,nerve
R1878	T6495	T6493	pobj	nerve,in
R1879	T6496	T6495	amod	tibial,nerve
R188	T1205	T1202	conj	Chen,Frank
R1880	T6497	T6480	cc	but,seen
R1881	T6498	T6499	expl	there,were
R1882	T6499	T6480	conj	were,seen
R1883	T6500	T6501	det	no,axons
R1884	T6501	T6499	attr	axons,were
R1885	T6502	T6503	npadvmod	TrkC,positive
R1886	T6503	T6501	amod	positive,axons
R1887	T6504	T6503	punct	-,positive
R1888	T6505	T6492	punct	;,are
R1889	T6506	T6492	prep	in,are
R189	T1206	T1205	nmod	et,Chen
R1890	T6507	T6506	pobj	contrast,in
R1891	T6508	T6492	punct	", ",are
R1892	T6509	T6510	npadvmod	TrkA,labeled
R1893	T6510	T6515	amod	labeled,axons
R1894	T6511	T6509	punct	-,TrkA
R1895	T6512	T6509	cc	and,TrkA
R1896	T6513	T6509	conj	TrkC,TrkA
R1897	T6514	T6510	punct	-,labeled
R1898	T6515	T6492	nsubj	axons,are
R1899	T6516	T6492	advmod	both,are
R19	T448	T451	compound	knockout,mice
R190	T1207	T1205	nmod	al.,Chen
R1900	T6517	T6492	acomp	present,are
R1901	T6518	T6492	prep	in,are
R1902	T6519	T6520	nmod	WT,animals
R1903	T6520	T6518	pobj	animals,in
R1904	T6521	T6519	punct	", ",WT
R1905	T6522	T6523	compound	Bax,KO
R1906	T6523	T6519	conj	KO,WT
R1907	T6524	T6523	punct	", ",KO
R1908	T6525	T6523	cc	and,KO
R1909	T6526	T6527	amod	double,KO
R191	T1208	T1205	nummod	2003,Chen
R1910	T6527	T6523	conj	KO,KO
R1911	T6528	T6529	punct	(,4F
R1912	T6529	T6492	parataxis	4F,are
R1913	T6530	T6529	compound	Figure,4F
R1914	T6531	T6529	punct	),4F
R1915	T6532	T6492	punct	.,are
R1916	T6534	T6535	det	These,results
R1917	T6535	T6536	nsubj	results,suggest
R1918	T6537	T6538	mark	that,fail
R1919	T6538	T6536	ccomp	fail,suggest
R192	T1209	T1205	punct	),Chen
R1920	T6539	T6540	mark	although,follow
R1921	T6540	T6538	advcl	follow,fail
R1922	T6541	T6542	amod	proprioceptive,axons
R1923	T6542	T6540	nsubj	axons,follow
R1924	T6543	T6544	amod	proper,trajectories
R1925	T6544	T6540	dobj	trajectories,follow
R1926	T6545	T6540	prep	in,follow
R1927	T6546	T6547	amod	distal,nerves
R1928	T6547	T6545	pobj	nerves,in
R1929	T6548	T6547	amod	peripheral,nerves
R193	T1210	T1179	punct	.,is
R1930	T6549	T6538	punct	", ",fail
R1931	T6550	T6538	nsubj	they,fail
R1932	T6551	T6552	aux	to,innervate
R1933	T6552	T6538	xcomp	innervate,fail
R1934	T6553	T6554	poss	their,muscles
R1935	T6554	T6552	dobj	muscles,innervate
R1936	T6555	T6554	compound	target,muscles
R1937	T6556	T6552	prep	in,innervate
R1938	T6557	T6558	det	the,absence
R1939	T6558	T6556	pobj	absence,in
R194	T1212	T1213	nsubj	Mice,display
R1940	T6559	T6558	prep	of,absence
R1941	T6560	T6559	pobj	NT,of
R1942	T6561	T6560	punct	-,NT
R1943	T6562	T6560	nummod	3,NT
R1944	T6563	T6536	punct	.,suggest
R1945	T7869	T7870	nsubj	NT,Is
R1946	T7871	T7869	punct	-,NT
R1947	T7872	T7869	nummod	3,NT
R1948	T7873	T7874	det	a,Chemoattractant
R1949	T7874	T7870	attr	Chemoattractant,Is
R195	T1214	T1212	amod	deficient,Mice
R1950	T7875	T7874	prep	for,Chemoattractant
R1951	T7876	T7877	compound	DRG,Axons
R1952	T7877	T7875	pobj	Axons,for
R1953	T7878	T7879	advmod	In,Vitro
R1954	T7879	T7870	advmod	Vitro,Is
R1955	T7881	T7882	aux	To,test
R1956	T7882	T7883	advcl	test,performed
R1957	T7884	T7885	det	the,hypothesis
R1958	T7885	T7882	dobj	hypothesis,test
R1959	T7886	T7887	mark	that,acts
R196	T1215	T1214	prep	in,deficient
R1960	T7887	T7885	acl	acts,hypothesis
R1961	T7888	T7887	nsubj	NT,acts
R1962	T7889	T7888	punct	-,NT
R1963	T7890	T7888	nummod	3,NT
R1964	T7891	T7887	prep	as,acts
R1965	T7892	T7893	det	a,chemoattractant
R1966	T7893	T7891	pobj	chemoattractant,as
R1967	T7894	T7893	prep	for,chemoattractant
R1968	T7895	T7896	amod	sensory,axons
R1969	T7896	T7894	pobj	axons,for
R197	T1216	T1215	pobj	NT,in
R1970	T7897	T7883	punct	", ",performed
R1971	T7898	T7883	nsubj	we,performed
R1972	T7899	T7900	det	a,series
R1973	T7900	T7883	dobj	series,performed
R1974	T7901	T7900	prep	of,series
R1975	T7902	T7903	advmod	in,vitro
R1976	T7903	T7904	amod	vitro,assays
R1977	T7904	T7901	pobj	assays,of
R1978	T7905	T7883	punct	.,performed
R1979	T7907	T7908	amod	Proprioceptive,axons
R198	T1217	T1216	punct	-,NT
R1980	T7908	T7909	nsubj	axons,enter
R1981	T7910	T7908	prep	in,axons
R1982	T7911	T7910	pobj	mice,in
R1983	T7912	T7913	det	the,matter
R1984	T7913	T7909	dobj	matter,enter
R1985	T7914	T7913	amod	gray,matter
R1986	T7915	T7913	prep	in,matter
R1987	T7916	T7917	det	the,cord
R1988	T7917	T7915	pobj	cord,in
R1989	T7918	T7917	amod	spinal,cord
R199	T1218	T1216	nummod	3,NT
R1990	T7919	T7909	cc	and,enter
R1991	T7920	T7909	conj	advance,enter
R1992	T7921	T7920	advmod	ventrally,advance
R1993	T7922	T7920	advcl	parallel,advance
R1994	T7923	T7922	prep	to,parallel
R1995	T7924	T7925	det	the,midline
R1996	T7925	T7923	pobj	midline,to
R1997	T7926	T7920	prep	by,advance
R1998	T7927	T7926	pobj	E13,by
R1999	T7928	T7920	cc	and,advance
R2	T429	T428	punct	-,NT
R20	T449	T447	punct	-,NT
R200	T1219	T1216	punct	", ",NT
R2000	T7929	T7920	conj	reach,advance
R2001	T7930	T7931	det	the,neurons
R2002	T7931	T7929	dobj	neurons,reach
R2003	T7932	T7931	compound	motor,neurons
R2004	T7933	T7929	prep	by,reach
R2005	T7934	T7933	pobj	E15,by
R2006	T7935	T7936	punct	(,Ozaki
R2007	T7936	T7929	meta	Ozaki,reach
R2008	T7937	T7936	cc	and,Ozaki
R2009	T7938	T7936	conj	Snider,Ozaki
R201	T1220	T1221	poss	its,receptor
R2010	T7939	T7938	nummod	1994,Snider
R2011	T7940	T7938	punct	),Snider
R2012	T7941	T7909	punct	.,enter
R2013	T7943	T7944	nsubj	We,co-cultured
R2014	T7945	T7946	npadvmod	collagen,embedded
R2015	T7946	T7948	amod	embedded,explants
R2016	T7947	T7946	punct	-,embedded
R2017	T7948	T7944	dobj	explants,co-cultured
R2018	T7949	T7948	compound	E13,explants
R2019	T7950	T7948	compound	WT,explants
R202	T1221	T1216	appos	receptor,NT
R2020	T7951	T7948	compound	DRG,explants
R2021	T7952	T7944	prep	with,co-cultured
R2022	T7953	T7954	npadvmod	NT,soaked
R2023	T7954	T7958	amod	soaked,beads
R2024	T7955	T7953	punct	-,NT
R2025	T7956	T7953	nummod	3,NT
R2026	T7957	T7954	punct	-,soaked
R2027	T7958	T7952	pobj	beads,with
R2028	T7959	T7958	compound	sepharose,beads
R2029	T7960	T7961	punct	(,26
R203	T1222	T1221	compound	tyrosine,receptor
R2030	T7961	T7944	parataxis	26,co-cultured
R2031	T7962	T7961	nsubj	n,26
R2032	T7963	T7961	punct	=,26
R2033	T7964	T7961	punct	),26
R2034	T7965	T7944	punct	.,co-cultured
R2035	T7967	T7968	compound	Control,cultures
R2036	T7968	T7969	nsubjpass	cultures,set
R2037	T7970	T7969	auxpass	were,set
R2038	T7971	T7969	prt	up,set
R2039	T7972	T7969	advcl	using,set
R204	T1223	T1221	compound	kinase,receptor
R2040	T7973	T7974	amod	bovine,albumin
R2041	T7974	T7976	npadvmod	albumin,soaked
R2042	T7975	T7974	compound	serum,albumin
R2043	T7976	T7989	amod	soaked,beads
R2044	T7977	T7974	punct	(,albumin
R2045	T7978	T7974	appos	BSA,albumin
R2046	T7979	T7974	punct	),albumin
R2047	T7980	T7974	punct	–,albumin
R2048	T7981	T7974	cc	or,albumin
R2049	T7982	T7983	compound	phosphate,saline
R205	T1224	T1221	punct	", ",receptor
R2050	T7983	T7974	conj	saline,albumin
R2051	T7984	T7983	compound	buffer,saline
R2052	T7985	T7983	punct	(,saline
R2053	T7986	T7983	appos	PBS,saline
R2054	T7987	T7976	punct	),soaked
R2055	T7988	T7976	punct	–,soaked
R2056	T7989	T7972	dobj	beads,using
R2057	T7990	T7991	punct	(,12
R2058	T7991	T7972	parataxis	12,using
R2059	T7992	T7991	nsubj	n,12
R206	T1225	T1221	appos	TrkC,receptor
R2060	T7993	T7991	punct	=,12
R2061	T7994	T7991	punct	),12
R2062	T7995	T7969	punct	.,set
R2063	T7997	T7998	compound	DRG,axons
R2064	T7998	T7999	nsubj	axons,began
R2065	T8000	T7999	xcomp	extending,began
R2066	T8001	T8000	prep	towards,extending
R2067	T8002	T8003	det	the,source
R2068	T8003	T8001	pobj	source,towards
R2069	T8004	T8003	amod	localized,source
R207	T1226	T1215	punct	", ",in
R2070	T8005	T8003	nmod	NT,source
R2071	T8006	T8005	punct	-,NT
R2072	T8007	T8005	nummod	3,NT
R2073	T8008	T8000	prep	by,extending
R2074	T8009	T8010	det	the,end
R2075	T8010	T8008	pobj	end,by
R2076	T8011	T8010	prep	of,end
R2077	T8012	T8013	det	the,day
R2078	T8013	T8011	pobj	day,of
R2079	T8014	T8013	amod	first,day
R208	T1227	T1215	cc	or,in
R2080	T8015	T7999	cc	and,began
R2081	T8016	T8017	advmod	consistently,displayed
R2082	T8017	T7999	conj	displayed,began
R2083	T8018	T8019	det	a,chemoattraction
R2084	T8019	T8017	dobj	chemoattraction,displayed
R2085	T8020	T8019	amod	strong,chemoattraction
R2086	T8021	T8017	prep	by,displayed
R2087	T8022	T8023	nummod	3,d
R2088	T8023	T8021	pobj	d,by
R2089	T8024	T8025	advmod	in,vitro
R209	T1228	T1215	conj	in,in
R2090	T8025	T8023	advmod	vitro,d
R2091	T8026	T8017	punct	", ",displayed
R2092	T8027	T8028	mark	whereas,show
R2093	T8028	T8017	advcl	show,displayed
R2094	T8029	T8028	nsubj	they,show
R2095	T8030	T8028	aux	did,show
R2096	T8031	T8028	neg	not,show
R2097	T8032	T8033	amod	such,preference
R2098	T8033	T8028	dobj	preference,show
R2099	T8034	T8033	prep	for,preference
R21	T450	T447	nummod	3,NT
R210	T1229	T1230	npadvmod	TrkC,positive
R2100	T8035	T8036	npadvmod	BSA,loaded
R2101	T8036	T8038	amod	loaded,beads
R2102	T8037	T8036	punct	-,loaded
R2103	T8038	T8034	pobj	beads,for
R2104	T8039	T8038	compound	control,beads
R2105	T8040	T8041	punct	(,5A
R2106	T8041	T8017	parataxis	5A,displayed
R2107	T8042	T8041	compound	Figure,5A
R2108	T8043	T8041	cc	and,5A
R2109	T8044	T8041	conj	5B,5A
R211	T1230	T1232	amod	positive,factor
R2110	T8045	T8041	punct	),5A
R2111	T8046	T7999	punct	.,began
R2112	T8048	T8049	det	This,attraction
R2113	T8049	T8050	nsubj	attraction,was
R2114	T8051	T8050	neg	not,was
R2115	T8052	T8050	prep	due,was
R2116	T8053	T8052	pcomp	to,due
R2117	T8054	T8055	compound	survival,support
R2118	T8055	T8052	pobj	support,due
R2119	T8056	T8055	prep	of,support
R212	T1231	T1230	punct	-,positive
R2120	T8057	T8056	pobj	NT,of
R2121	T8058	T8057	punct	-,NT
R2122	T8059	T8057	nummod	3,NT
R2123	T8060	T8061	mark	because,displayed
R2124	T8061	T8050	advcl	displayed,was
R2125	T8062	T8063	npadvmod	Bax,null
R2126	T8063	T8064	amod	null,ganglia
R2127	T8064	T8061	nsubj	ganglia,displayed
R2128	T8065	T8066	det	the,chemoattraction
R2129	T8066	T8061	dobj	chemoattraction,displayed
R213	T1232	T1237	compound	factor,Runx3
R2130	T8067	T8066	amod	same,chemoattraction
R2131	T8068	T8069	punct	(,5C
R2132	T8069	T8050	parataxis	5C,was
R2133	T8070	T8069	compound	Figure,5C
R2134	T8071	T8069	punct	;,5C
R2135	T8072	T8073	nsubj	n,16
R2136	T8073	T8069	ccomp	16,5C
R2137	T8074	T8073	punct	=,16
R2138	T8075	T8069	punct	),5C
R2139	T8076	T8050	punct	.,was
R214	T1233	T1232	nmod	neuron,factor
R2140	T8078	T8079	nsubj	NT,act
R2141	T8080	T8078	punct	-,NT
R2142	T8081	T8078	nummod	3,NT
R2143	T8082	T8079	aux	may,act
R2144	T8083	T8079	prep	through,act
R2145	T8084	T8085	preconj	either,TrkC
R2146	T8085	T8083	pobj	TrkC,through
R2147	T8086	T8085	punct	", ",TrkC
R2148	T8087	T8085	cc	or,TrkC
R2149	T8088	T8089	det	the,p75NTR
R215	T1234	T1233	punct	-,neuron
R2150	T8089	T8085	conj	p75NTR,TrkC
R2151	T8090	T8079	punct	.,act
R2152	T8092	T8093	nsubj	We,repeated
R2153	T8094	T8095	det	the,experiments
R2154	T8095	T8093	dobj	experiments,repeated
R2155	T8096	T8095	compound	co-culture,experiments
R2156	T8097	T8093	prep	with,repeated
R2157	T8098	T8099	compound	DRG,explants
R2158	T8099	T8097	pobj	explants,with
R2159	T8100	T8099	acl	derived,explants
R216	T1235	T1233	amod	specific,neuron
R2160	T8101	T8100	prep	from,derived
R2161	T8102	T8103	compound	p75NTR,KO
R2162	T8103	T8104	compound	KO,mice
R2163	T8104	T8101	pobj	mice,from
R2164	T8105	T8106	punct	(,18
R2165	T8106	T8093	parataxis	18,repeated
R2166	T8107	T8106	nsubj	n,18
R2167	T8108	T8106	punct	=,18
R2168	T8109	T8106	punct	),18
R2169	T8110	T8093	punct	.,repeated
R217	T1236	T1232	compound	transcription,factor
R2170	T8112	T8113	nsubj	Axons,showed
R2171	T8114	T8112	prep	of,Axons
R2172	T8115	T8116	det	these,ganglia
R2173	T8116	T8114	pobj	ganglia,of
R2174	T8117	T8113	advmod	also,showed
R2175	T8118	T8119	amod	strong,chemoattraction
R2176	T8119	T8113	dobj	chemoattraction,showed
R2177	T8120	T8119	prep	towards,chemoattraction
R2178	T8121	T8122	det	the,beads
R2179	T8122	T8120	pobj	beads,towards
R218	T1237	T1228	pobj	Runx3,in
R2180	T8123	T8122	nmod	NT,beads
R2181	T8124	T8123	punct	-,NT
R2182	T8125	T8123	nummod	3,NT
R2183	T8126	T8127	punct	(,5D
R2184	T8127	T8113	parataxis	5D,showed
R2185	T8128	T8127	compound	Figure,5D
R2186	T8129	T8127	punct	),5D
R2187	T8130	T8113	punct	.,showed
R2188	T8132	T8133	advmod	Finally,used
R2189	T8134	T8133	punct	", ",used
R219	T1238	T1239	amod	severe,ataxia
R2190	T8135	T8133	nsubj	we,used
R2191	T8136	T8137	amod	diffusible,receptors
R2192	T8137	T8133	dobj	receptors,used
R2193	T8138	T8137	compound	TrkC,receptors
R2194	T8139	T8137	acl	conjugated,receptors
R2195	T8140	T8139	prep	to,conjugated
R2196	T8141	T8142	compound	IgG,regions
R2197	T8142	T8140	pobj	regions,to
R2198	T8143	T8142	compound	constant,regions
R2199	T8144	T8145	punct	(,Fc
R22	T451	T446	pobj	mice,in
R220	T1239	T1213	dobj	ataxia,display
R2200	T8145	T8142	parataxis	Fc,regions
R2201	T8146	T8145	compound	TrkC,Fc
R2202	T8147	T8145	punct	-,Fc
R2203	T8148	T8145	punct	),Fc
R2204	T8149	T8142	acl	added,regions
R2205	T8150	T8149	prep	to,added
R2206	T8151	T8152	det	the,medium
R2207	T8152	T8150	pobj	medium,to
R2208	T8153	T8154	punct	(,6
R2209	T8154	T8149	parataxis	6,added
R221	T1240	T1239	acl	associated,ataxia
R2210	T8155	T8154	nsubj	n,6
R2211	T8156	T8154	punct	=,6
R2212	T8157	T8154	punct	),6
R2213	T8158	T8159	aux	to,deplete
R2214	T8159	T8133	advcl	deplete,used
R2215	T8160	T8161	amod	soluble,NT
R2216	T8161	T8159	dobj	NT,deplete
R2217	T8162	T8161	punct	-,NT
R2218	T8163	T8161	nummod	3,NT
R2219	T8164	T8159	prep	from,deplete
R222	T1241	T1240	prep	with,associated
R2220	T8165	T8166	det	the,gels
R2221	T8166	T8164	pobj	gels,from
R2222	T8167	T8166	compound	collagen,gels
R2223	T8168	T8169	punct	(,5E
R2224	T8169	T8133	parataxis	5E,used
R2225	T8170	T8169	compound	Figure,5E
R2226	T8171	T8169	punct	),5E
R2227	T8172	T8133	punct	.,used
R2228	T8174	T8175	prep	In,blocked
R2229	T8176	T8177	det	the,presence
R223	T1242	T1243	det	the,absence
R2230	T8177	T8174	pobj	presence,In
R2231	T8178	T8177	prep	of,presence
R2232	T8179	T8180	compound	TrkC,Fc
R2233	T8180	T8178	pobj	Fc,of
R2234	T8181	T8180	punct	-,Fc
R2235	T8182	T8183	det	the,chemoattraction
R2236	T8183	T8175	nsubjpass	chemoattraction,blocked
R2237	T8184	T8175	auxpass	was,blocked
R2238	T8185	T8175	advmod	completely,blocked
R2239	T8186	T8175	punct	", ",blocked
R224	T1243	T1241	pobj	absence,with
R2240	T8187	T8175	advcl	demonstrating,blocked
R2241	T8188	T8189	mark	that,is
R2242	T8189	T8187	ccomp	is,demonstrating
R2243	T8190	T8191	det	the,effect
R2244	T8191	T8189	nsubj	effect,is
R2245	T8192	T8193	nsubj	we,see
R2246	T8193	T8191	advcl	see,effect
R2247	T8194	T8189	acomp	specific,is
R2248	T8195	T8194	prep	for,specific
R2249	T8196	T8195	pobj	NT,for
R225	T1244	T1243	prep	of,absence
R2250	T8197	T8196	punct	-,NT
R2251	T8198	T8196	nummod	3,NT
R2252	T8199	T8175	punct	.,blocked
R2253	T8201	T8202	prep	In,repeated
R2254	T8203	T8201	pobj	order,In
R2255	T8204	T8205	aux	to,investigate
R2256	T8205	T8203	acl	investigate,order
R2257	T8206	T8207	det	the,range
R2258	T8207	T8205	dobj	range,investigate
R2259	T8208	T8207	amod	active,range
R226	T1245	T1246	compound	muscle,spindles
R2260	T8209	T8207	prep	of,range
R2261	T8210	T8211	poss	our,beads
R2262	T8211	T8209	pobj	beads,of
R2263	T8212	T8202	punct	", ",repeated
R2264	T8213	T8202	nsubj	we,repeated
R2265	T8214	T8202	aux	have,repeated
R2266	T8215	T8216	det	the,cultures
R2267	T8216	T8202	dobj	cultures,repeated
R2268	T8217	T8202	prep	with,repeated
R2269	T8218	T8219	compound	WT,DRGs
R227	T1246	T1244	pobj	spindles,of
R2270	T8219	T8217	pobj	DRGs,with
R2271	T8220	T8219	compound	E13,DRGs
R2272	T8221	T8202	prep	by,repeated
R2273	T8222	T8221	pcomp	placing,by
R2274	T8223	T8224	det	the,beads
R2275	T8224	T8222	dobj	beads,placing
R2276	T8225	T8222	prep	at,placing
R2277	T8226	T8227	amod	increasing,distances
R2278	T8227	T8225	pobj	distances,at
R2279	T8228	T8227	prep	from,distances
R228	T1247	T1239	punct	", ",ataxia
R2280	T8229	T8230	det	the,ganglia
R2281	T8230	T8228	pobj	ganglia,from
R2282	T8231	T8232	punct	(,4
R2283	T8232	T8222	parataxis	4,placing
R2284	T8233	T8232	nsubj	n,4
R2285	T8234	T8232	punct	=,4
R2286	T8235	T8232	appos	each,4
R2287	T8236	T8232	punct	),4
R2288	T8237	T8238	punct	(,5F
R2289	T8238	T8222	parataxis	5F,placing
R229	T1248	T1239	cc	and,ataxia
R2290	T8239	T8238	compound	Figure,5F
R2291	T8240	T8238	punct	),5F
R2292	T8241	T8202	punct	.,repeated
R2293	T8243	T8244	expl	There,was
R2294	T8245	T8244	advmod	still,was
R2295	T8246	T8247	amod	preferred,growth
R2296	T8247	T8244	attr	growth,was
R2297	T8248	T8247	prep	towards,growth
R2298	T8249	T8250	det	the,bead
R2299	T8250	T8248	pobj	bead,towards
R23	T452	T453	det	these,neurons
R230	T1249	T1239	conj	loss,ataxia
R2300	T8251	T8250	prep	at,bead
R2301	T8252	T8253	nummod	"1,200",μm
R2302	T8253	T8251	pobj	μm,at
R2303	T8254	T8253	punct	", ",μm
R2304	T8255	T8256	det	the,distance
R2305	T8256	T8253	appos	distance,μm
R2306	T8257	T8256	amod	longest,distance
R2307	T8258	T8256	acl	studied,distance
R2308	T8259	T8244	punct	", ",was
R2309	T8260	T8261	mark	although,were
R231	T1250	T1249	prep	of,loss
R2310	T8261	T8244	advcl	were,was
R2311	T8262	T8263	det	the,number
R2312	T8263	T8261	nsubj	number,were
R2313	T8264	T8263	prep	of,number
R2314	T8265	T8264	pobj	axons,of
R2315	T8266	T8263	cc	and,number
R2316	T8267	T8268	det	the,extent
R2317	T8268	T8263	conj	extent,number
R2318	T8269	T8268	prep	of,extent
R2319	T8270	T8269	pobj	growth,of
R232	T1251	T1252	amod	proprioceptive,neurons
R2320	T8271	T8261	neg	not,were
R2321	T8272	T8273	advmod	as,robust
R2322	T8273	T8261	acomp	robust,were
R2323	T8274	T8244	punct	.,was
R2324	T8276	T8277	advmod	Next,set
R2325	T8278	T8277	punct	", ",set
R2326	T8279	T8277	nsubj	we,set
R2327	T8280	T8277	prt	up,set
R2328	T8281	T8282	nmod	E13,cultures
R2329	T8282	T8277	dobj	cultures,set
R233	T1252	T1250	pobj	neurons,of
R2330	T8283	T8282	nmod	DRG,cultures
R2331	T8284	T8285	amod	spinal,cord
R2332	T8285	T8282	compound	cord,cultures
R2333	T8286	T8282	compound	explant,cultures
R2334	T8287	T8277	advcl	using,set
R2335	T8288	T8289	npadvmod	NT,loaded
R2336	T8289	T8293	amod	loaded,beads
R2337	T8290	T8288	punct	-,NT
R2338	T8291	T8288	nummod	3,NT
R2339	T8292	T8289	punct	-,loaded
R234	T1253	T1252	prep	in,neurons
R2340	T8293	T8287	dobj	beads,using
R2341	T8294	T8293	acl	placed,beads
R2342	T8295	T8294	prep	at,placed
R2343	T8296	T8297	det	the,midline
R2344	T8297	T8295	pobj	midline,at
R2345	T8298	T8297	prep	at,midline
R2346	T8299	T8300	amod	mid-spinal,level
R2347	T8300	T8298	pobj	level,at
R2348	T8301	T8300	compound	cord,level
R2349	T8302	T8287	prep	as,using
R235	T1254	T1255	amod	dorsal,root
R2350	T8303	T8304	det	an,source
R2351	T8304	T8302	pobj	source,as
R2352	T8305	T8304	amod	ectopic,source
R2353	T8306	T8304	nmod	NT,source
R2354	T8307	T8306	punct	-,NT
R2355	T8308	T8306	nummod	3,NT
R2356	T8309	T8310	punct	(,15
R2357	T8310	T8277	parataxis	15,set
R2358	T8311	T8310	nsubj	n,15
R2359	T8312	T8310	punct	=,15
R236	T1255	T1256	compound	root,ganglia
R2360	T8313	T8310	punct	),15
R2361	T8314	T8277	punct	.,set
R2362	T8316	T8317	compound	Control,cultures
R2363	T8317	T8318	nsubjpass	cultures,set
R2364	T8319	T8318	auxpass	were,set
R2365	T8320	T8318	advcl	using,set
R2366	T8321	T8322	npadvmod	PBS,loaded
R2367	T8322	T8324	amod	loaded,beads
R2368	T8323	T8322	punct	-,loaded
R2369	T8324	T8320	dobj	beads,using
R237	T1256	T1253	pobj	ganglia,in
R2370	T8325	T8326	punct	(,6
R2371	T8326	T8320	parataxis	6,using
R2372	T8327	T8326	nsubj	n,6
R2373	T8328	T8326	punct	=,6
R2374	T8329	T8326	punct	),6
R2375	T8330	T8318	punct	.,set
R2376	T8332	T8333	compound	DiI,labeling
R2377	T8333	T8334	nsubj	labeling,revealed
R2378	T8335	T8333	prep	through,labeling
R2379	T8336	T8337	det	the,DRGs
R238	T1257	T1256	punct	(,ganglia
R2380	T8337	T8335	pobj	DRGs,through
R2381	T8338	T8339	amod	numerous,fibers
R2382	T8339	T8334	dobj	fibers,revealed
R2383	T8340	T8339	acl	entering,fibers
R2384	T8341	T8342	det	the,cord
R2385	T8342	T8340	dobj	cord,entering
R2386	T8343	T8342	amod	spinal,cord
R2387	T8344	T8340	prep	at,entering
R2388	T8345	T8346	amod	ectopic,regions
R2389	T8346	T8344	pobj	regions,at
R239	T1258	T1256	appos	DRGs,ganglia
R2390	T8347	T8340	cc	and,entering
R2391	T8348	T8340	conj	growing,entering
R2392	T8349	T8348	prep	towards,growing
R2393	T8350	T8351	det	the,beads
R2394	T8351	T8349	pobj	beads,towards
R2395	T8352	T8351	nmod	NT,beads
R2396	T8353	T8352	punct	-,NT
R2397	T8354	T8352	nummod	3,NT
R2398	T8355	T8356	punct	(,6A
R2399	T8356	T8349	parataxis	6A,towards
R24	T453	T440	dobj	neurons,rescues
R240	T1259	T1256	punct	),ganglia
R2400	T8357	T8356	compound	Figure,6A
R2401	T8358	T8356	punct	),6A
R2402	T8359	T8340	punct	", ",entering
R2403	T8360	T8340	dep	surrounding,entering
R2404	T8361	T8362	det	the,beads
R2405	T8362	T8360	dobj	beads,surrounding
R2406	T8363	T8360	cc	and,surrounding
R2407	T8364	T8360	conj	forming,surrounding
R2408	T8365	T8364	dobj	bundles,forming
R2409	T8366	T8364	prep	around,forming
R241	T1260	T1256	cc	or,ganglia
R2410	T8367	T8366	pobj	them,around
R2411	T8368	T8369	punct	(,6C
R2412	T8369	T8334	parataxis	6C,revealed
R2413	T8370	T8369	compound	Figure,6C
R2414	T8371	T8372	punct	–,6E
R2415	T8372	T8369	prep	6E,6C
R2416	T8373	T8369	punct	),6C
R2417	T8374	T8334	punct	.,revealed
R2418	T8376	T8377	prep	In,directed
R2419	T8378	T8379	compound	control,cultures
R242	T1261	T1262	poss	their,axons
R2420	T8379	T8376	pobj	cultures,In
R2421	T8380	T8377	punct	", ",directed
R2422	T8381	T8382	det	all,fibers
R2423	T8382	T8377	nsubjpass	fibers,directed
R2424	T8383	T8382	amod	labeled,fibers
R2425	T8384	T8377	auxpass	were,directed
R2426	T8385	T8377	prep	towards,directed
R2427	T8386	T8387	det	the,cord
R2428	T8387	T8385	pobj	cord,towards
R2429	T8388	T8387	amod	dorsal,cord
R243	T1262	T1256	conj	axons,ganglia
R2430	T8389	T8387	amod	spinal,cord
R2431	T8390	T8377	cc	and,directed
R2432	T8391	T8377	conj	terminated,directed
R2433	T8392	T8391	advmod	there,terminated
R2434	T8393	T8391	punct	", ",terminated
R2435	T8394	T8395	advmod	where,enter
R2436	T8395	T8391	advcl	enter,terminated
R2437	T8396	T8395	nsubj	they,enter
R2438	T8397	T8395	advmod	normally,enter
R2439	T8398	T8399	det	the,matter
R244	T1263	T1264	punct	(,Ernfors
R2440	T8399	T8395	dobj	matter,enter
R2441	T8400	T8399	amod	gray,matter
R2442	T8401	T8395	prep	at,enter
R2443	T8402	T8401	pobj	E13,at
R2444	T8403	T8404	punct	(,6B
R2445	T8404	T8391	parataxis	6B,terminated
R2446	T8405	T8404	compound	Figure,6B
R2447	T8406	T8404	punct	),6B
R2448	T8407	T8377	punct	.,directed
R2449	T8409	T8410	det	No,axons
R245	T1264	T1213	meta	Ernfors,display
R2450	T8410	T8411	nsubjpass	axons,observed
R2451	T8412	T8411	auxpass	were,observed
R2452	T8413	T8411	prep	around,observed
R2453	T8414	T8415	det	the,beads
R2454	T8415	T8413	pobj	beads,around
R2455	T8416	T8417	npadvmod	PBS,loaded
R2456	T8417	T8415	amod	loaded,beads
R2457	T8418	T8417	punct	-,loaded
R2458	T8419	T8415	compound	control,beads
R2459	T8420	T8421	punct	(,6F
R246	T1265	T1264	nmod	et,Ernfors
R2460	T8421	T8411	parataxis	6F,observed
R2461	T8422	T8421	compound	Figure,6F
R2462	T8423	T8421	punct	),6F
R2463	T8424	T8411	punct	.,observed
R2464	T8426	T8427	nsubj	Axons,grow
R2465	T8428	T8429	dep	that,enter
R2466	T8429	T8426	relcl	enter,Axons
R2467	T8430	T8429	advmod	normally,enter
R2468	T8431	T8432	det	the,matter
R2469	T8432	T8429	dobj	matter,enter
R247	T1266	T1264	nmod	al.,Ernfors
R2470	T8433	T8432	amod	gray,matter
R2471	T8434	T8429	prep	through,enter
R2472	T8435	T8436	amod	dorsal,cord
R2473	T8436	T8434	pobj	cord,through
R2474	T8437	T8436	amod	spinal,cord
R2475	T8438	T8427	prep	towards,grow
R2476	T8439	T8440	det	the,midline
R2477	T8440	T8438	pobj	midline,towards
R2478	T8441	T8442	advmod	when,presented
R2479	T8442	T8427	advcl	presented,grow
R248	T1267	T1264	nummod	1994,Ernfors
R2480	T8443	T8442	prep	with,presented
R2481	T8444	T8445	det	a,source
R2482	T8445	T8443	pobj	source,with
R2483	T8446	T8445	amod	localized,source
R2484	T8447	T8445	nmod	NT,source
R2485	T8448	T8447	punct	-,NT
R2486	T8449	T8447	nummod	3,NT
R2487	T8450	T8427	punct	", ",grow
R2488	T8451	T8427	cc	and,grow
R2489	T8452	T8453	amod	new,growth
R249	T1268	T1264	punct	;,Ernfors
R2490	T8453	T8455	nsubjpass	growth,initiated
R2491	T8454	T8453	compound	axon,growth
R2492	T8455	T8427	conj	initiated,grow
R2493	T8456	T8453	prep	towards,growth
R2494	T8457	T8458	det	the,bead
R2495	T8458	T8456	pobj	bead,towards
R2496	T8459	T8458	nmod	NT,bead
R2497	T8460	T8459	punct	-,NT
R2498	T8461	T8459	nummod	3,NT
R2499	T8462	T8455	auxpass	is,initiated
R25	T454	T440	cc	and,rescues
R250	T1269	T1264	nmod	Klein,Ernfors
R2500	T8463	T8455	prep	from,initiated
R2501	T8464	T8463	pobj	DRGs,from
R2502	T8465	T8455	punct	", ",initiated
R2503	T8466	T8455	advcl	entering,initiated
R2504	T8467	T8468	det	the,cord
R2505	T8468	T8466	dobj	cord,entering
R2506	T8469	T8468	amod	spinal,cord
R2507	T8470	T8466	prep	at,entering
R2508	T8471	T8472	amod	ectopic,loci
R2509	T8472	T8470	pobj	loci,at
R251	T1270	T1264	nmod	et,Ernfors
R2510	T8473	T8466	prep	at,entering
R2511	T8474	T8475	amod	lateral,cord
R2512	T8475	T8473	pobj	cord,at
R2513	T8476	T8475	amod	mid-spinal,cord
R2514	T8477	T8478	punct	(,6G
R2515	T8478	T8466	parataxis	6G,entering
R2516	T8479	T8478	compound	Figure,6G
R2517	T8480	T8478	punct	),6G
R2518	T8481	T8455	punct	.,initiated
R2519	T8483	T8484	nsubj	NT,is
R252	T1271	T1264	nmod	al.,Ernfors
R2520	T8485	T8483	punct	-,NT
R2521	T8486	T8483	nummod	3,NT
R2522	T8487	T8484	advmod	therefore,is
R2523	T8488	T8484	acomp	capable,is
R2524	T8489	T8488	prep	of,capable
R2525	T8490	T8489	pcomp	acting,of
R2526	T8491	T8490	prep	as,acting
R2527	T8492	T8493	det	a,chemoattractant
R2528	T8493	T8491	pobj	chemoattractant,as
R2529	T8494	T8493	prep	for,chemoattractant
R253	T1272	T1264	nummod	1994,Ernfors
R2530	T8495	T8496	compound	DRG,axons
R2531	T8496	T8494	pobj	axons,for
R2532	T8497	T8484	punct	.,is
R254	T1273	T1264	punct	;,Ernfors
R2541	T13466	T13463	pobj	cultures,in
R2542	T13384	T13385	advmod	Relatively,studies
R2543	T13385	T13387	nsubj	studies,implicated
R2544	T13386	T13385	amod	few,studies
R2545	T13388	T13387	aux	have,implicated
R2546	T13389	T13387	dobj	NT,implicated
R2547	T13390	T13389	punct	-,NT
R2548	T13391	T13389	nummod	3,NT
R2549	T13392	T13387	prep	as,implicated
R255	T1274	T1264	nmod	Tessarollo,Ernfors
R2550	T13393	T13394	det	a,agent
R2551	T13394	T13392	pobj	agent,as
R2552	T13395	T13394	amod	chemoattractant,agent
R2553	T13396	T13394	prep	for,agent
R2554	T13397	T13398	amod	sensory,axons
R2555	T13398	T13396	pobj	axons,for
R2556	T13399	T13397	cc	and,sensory
R2557	T13400	T13397	conj	motor,sensory
R2558	T13401	T13387	punct	.,implicated
R2559	T13467	T13457	advmod	preferentially,grow
R256	T1275	T1264	nmod	et,Ernfors
R2560	T13403	T13404	advmod	Previously,noted
R2561	T13404	T13405	amod	noted,action
R2562	T13468	T13457	prep	towards,grow
R2563	T13405	T13407	nsubjpass	action,attributed
R2564	T13406	T13405	compound	chemoattractant,action
R2565	T13408	T13405	prep	of,action
R2566	T13469	T13470	npadvmod	neurotrophin,soaked
R2567	T13409	T13410	det	the,process
R2568	T13410	T13408	pobj	process,of
R2569	T13411	T13412	amod	embryonic,mouse
R257	T1276	T1264	nmod	al.,Ernfors
R2570	T13470	T13472	amod	soaked,beads
R2571	T13412	T13410	nmod	mouse,process
R2572	T13413	T13410	amod	maxillary,process
R2573	T13471	T13470	punct	-,soaked
R2574	T13414	T13410	prep	on,process
R2575	T13415	T13416	amod	trigeminal,neurons
R2576	T13416	T13414	pobj	neurons,on
R2577	T13417	T13416	compound	ganglion,neurons
R2578	T13472	T13468	pobj	beads,towards
R2579	T13418	T13419	punct	(,Lumsden
R258	T1277	T1264	nummod	1994,Ernfors
R2580	T13419	T13405	meta	Lumsden,action
R2581	T13420	T13419	cc	and,Lumsden
R2582	T13473	T13474	advmod	instead,of
R2583	T13421	T13419	conj	Davies,Lumsden
R2584	T13422	T13421	nummod	1986,Davies
R2585	T13423	T13421	punct	),Davies
R2586	T13424	T13407	auxpass	is,attributed
R2587	T13425	T13407	advmod	now,attributed
R2588	T13426	T13407	prep	to,attributed
R2589	T13427	T13426	pobj	NT,to
R259	T1278	T1264	punct	;,Ernfors
R2590	T13474	T13457	prep	of,grow
R2591	T13428	T13427	punct	-,NT
R2592	T13429	T13427	nummod	3,NT
R2593	T13475	T13474	pcomp	following,of
R2594	T13430	T13427	cc	and,NT
R2595	T13431	T13432	npadvmod	brain,derived
R2596	T13476	T13477	poss	their,trajectories
R2597	T13432	T13434	amod	derived,factor
R2598	T13433	T13432	punct	-,derived
R2599	T13434	T13427	conj	factor,NT
R26	T455	T440	conj	allows,rescues
R260	T1279	T1264	nmod	Fariñas,Ernfors
R2600	T13477	T13475	dobj	trajectories,following
R2601	T13435	T13434	amod	neurotrophic,factor
R2602	T13436	T13434	punct	(,factor
R2603	T13478	T13477	amod	normal,trajectories
R2604	T13437	T13434	appos	BDNF,factor
R2605	T13438	T13407	punct	),attributed
R2606	T13439	T13440	punct	(,O'Connor
R2607	T13440	T13407	meta	O'Connor,attributed
R2608	T13441	T13440	nmod	et,O'Connor
R2609	T13479	T13448	punct	.,showed
R261	T1280	T1264	nmod	et,Ernfors
R2610	T13442	T13440	nmod	al.,O'Connor
R2611	T13443	T13440	nummod	1999,O'Connor
R2612	T13444	T13440	punct	),O'Connor
R2613	T13481	T13482	advmod	Conversely,led
R2614	T13445	T13407	punct	.,attributed
R2615	T13447	T13448	advmod	Recently,showed
R2616	T13483	T13482	punct	", ",led
R2617	T13449	T13448	punct	", ",showed
R2618	T13450	T13448	nsubj	Tucker,showed
R2619	T13451	T13452	advmod	et,al.
R262	T1281	T1264	nmod	al.,Ernfors
R2620	T13484	T13482	nsubj	beads,led
R2621	T13452	T13450	advmod	al.,Tucker
R2622	T13453	T13450	punct	(,Tucker
R2623	T13454	T13450	npadvmod	2001,Tucker
R2624	T13485	T13484	acl	soaked,beads
R2625	T13455	T13450	punct	),Tucker
R2626	T13456	T13457	mark	that,grow
R2627	T13457	T13448	ccomp	grow,showed
R2628	T13458	T13459	amod	developing,axons
R2629	T13486	T13485	prep	with,soaked
R263	T1282	T1264	nummod	1996,Ernfors
R2630	T13459	T13457	nsubj	axons,grow
R2631	T13460	T13459	amod	sensory,axons
R2632	T13461	T13460	cc	and,sensory
R2633	T13487	T13488	nmod	neurotrophin,antibodies
R2634	T13462	T13460	conj	motor,sensory
R2635	T13463	T13459	prep	in,axons
R2636	T13464	T13465	compound	limb,slice
R2637	T13465	T13466	compound	slice,cultures
R2638	T13488	T13486	pobj	antibodies,with
R2639	T13489	T13490	npadvmod	function,blocking
R264	T1283	T1264	punct	;,Ernfors
R2640	T13490	T13488	amod	blocking,antibodies
R2641	T13572	T13571	compound	chemoattractant,role
R2642	T13573	T13565	prep	during,play
R2643	T13491	T13490	punct	-,blocking
R2644	T13574	T13575	det	the,innervation
R2645	T13575	T13573	pobj	innervation,during
R2646	T13492	T13482	prep	to,led
R2647	T13576	T13575	prep	of,innervation
R2648	T13577	T13578	amod	ventral,horns
R2649	T13578	T13576	pobj	horns,of
R265	T1284	T1264	nmod	Liebl,Ernfors
R2650	T13493	T13492	pobj	reduction,to
R2651	T13579	T13575	prep	by,innervation
R2652	T13580	T13581	amod	proprioceptive,afferents
R2653	T13494	T13493	prep	of,reduction
R2654	T13581	T13579	pobj	afferents,by
R2655	T13582	T13559	punct	.,considered
R2656	T13495	T13496	amod	sensory,growth
R2657	T13584	T13585	advmod	However,led
R2658	T13586	T13585	punct	", ",led
R2659	T13496	T13494	pobj	growth,of
R266	T1285	T1264	nmod	et,Ernfors
R2660	T13587	T13588	amod	earlier,findings
R2661	T13588	T13585	nsubj	findings,led
R2662	T13497	T13495	cc	and,sensory
R2663	T13589	T13588	prep	of,findings
R2664	T13590	T13591	amod	normal,trajectories
R2665	T13498	T13495	conj	motor,sensory
R2666	T13591	T13589	pobj	trajectories,of
R2667	T13499	T13496	compound	axon,growth
R2668	T13592	T13591	amod	proprioceptive,trajectories
R2669	T13593	T13591	amod	afferent,trajectories
R267	T1286	T1264	nmod	al.,Ernfors
R2670	T13594	T13591	prep	in,trajectories
R2671	T13500	T13496	prep	towards,growth
R2672	T13595	T13596	compound	chicken,embryos
R2673	T13596	T13594	pobj	embryos,in
R2674	T13501	T13502	det	the,limb
R2675	T13597	T13588	prep	despite,findings
R2676	T13598	T13597	pobj	injection,despite
R2677	T13599	T13598	prep	of,injection
R2678	T13502	T13500	pobj	limb,towards
R2679	T13600	T13601	npadvmod	function,blocking
R268	T1287	T1264	nummod	1997,Ernfors
R2680	T13601	T13603	amod	blocking,antibody
R2681	T13503	T13482	punct	.,led
R2682	T13602	T13601	punct	-,blocking
R2683	T13505	T13506	prep	In,altered
R2684	T13603	T13599	pobj	antibody,of
R2685	T13604	T13603	nmod	NT,antibody
R2686	T13605	T13604	punct	-,NT
R2687	T13606	T13604	nummod	3,NT
R2688	T13607	T13598	prep	into,injection
R2689	T13608	T13609	det	the,cord
R269	T1288	T1264	punct	;,Ernfors
R2690	T13609	T13607	pobj	cord,into
R2691	T13610	T13609	amod	spinal,cord
R2692	T13611	T13612	punct	(,Oakley
R2693	T13612	T13588	meta	Oakley,findings
R2694	T13507	T13508	amod	transgenic,mice
R2695	T13613	T13612	nmod	et,Oakley
R2696	T13614	T13612	nmod	al.,Oakley
R2697	T13615	T13612	nummod	1995,Oakley
R2698	T13616	T13612	punct	),Oakley
R2699	T13617	T13585	dobj	them,led
R27	T456	T455	prep	for,allows
R270	T1289	T1264	nmod	Inoue,Ernfors
R2700	T13508	T13505	pobj	mice,In
R2701	T13618	T13619	aux	to,discount
R2702	T13619	T13585	xcomp	discount,led
R2703	T13620	T13621	det	this,possibility
R2704	T13621	T13619	dobj	possibility,discount
R2705	T13509	T13508	punct	", ",mice
R2706	T13622	T13585	punct	.,led
R2707	T13624	T13625	prep	In,showed
R2708	T13510	T13511	dep	which,over-express
R2709	T13626	T13627	det	that,study
R271	T1290	T1264	nmod	et,Ernfors
R2710	T13511	T13508	relcl	over-express,mice
R2711	T13627	T13624	pobj	study,In
R2712	T13628	T13625	punct	", ",showed
R2713	T13629	T13625	advmod	though,showed
R2714	T13512	T13511	dobj	NT,over-express
R2715	T13630	T13625	punct	", ",showed
R2716	T13631	T13625	nsubj	assays,showed
R2717	T13632	T13631	prep	on,assays
R2718	T13513	T13512	punct	-,NT
R2719	T13633	T13634	det	the,effectiveness
R272	T1291	T1264	nmod	al.,Ernfors
R2720	T13634	T13632	pobj	effectiveness,on
R2721	T13514	T13512	nummod	3,NT
R2722	T13635	T13634	prep	of,effectiveness
R2723	T13636	T13637	compound	antibody,perturbation
R2724	T13637	T13635	pobj	perturbation,of
R2725	T13638	T13634	prep	on,effectiveness
R2726	T13515	T13511	prep	under,over-express
R2727	T13639	T13640	npadvmod	NT,dependent
R2728	T13640	T13644	amod	dependent,survival
R2729	T13516	T13517	det	the,promoter
R273	T1292	T1264	nummod	2002,Ernfors
R2730	T13641	T13639	punct	-,NT
R2731	T13642	T13639	nummod	3,NT
R2732	T13643	T13640	punct	-,dependent
R2733	T13517	T13515	pobj	promoter,under
R2734	T13644	T13638	pobj	survival,on
R2735	T13645	T13644	compound	cell,survival
R2736	T13646	T13647	mark	that,was
R2737	T13518	T13517	compound	nestin,promoter
R2738	T13647	T13625	ccomp	was,showed
R2739	T13648	T13647	nsubj	effectiveness,was
R274	T1293	T1264	punct	;,Ernfors
R2740	T13649	T13647	acomp	significant,was
R2741	T13650	T13651	punct	(,%
R2742	T13651	T13649	parataxis	%,significant
R2743	T13652	T13653	advmod	approximately,90
R2744	T13519	T13511	prep	in,over-express
R2745	T13653	T13651	nummod	90,%
R2746	T13654	T13651	punct	),%
R2747	T13655	T13649	cc	but,significant
R2748	T13520	T13521	det	the,system
R2749	T13656	T13655	neg	not,but
R275	T1294	T1264	nmod	Levanon,Ernfors
R2750	T13657	T13649	conj	complete,significant
R2751	T13658	T13659	punct	(,Oakley
R2752	T13521	T13519	pobj	system,in
R2753	T13659	T13625	meta	Oakley,showed
R2754	T13660	T13659	nmod	et,Oakley
R2755	T13661	T13659	nmod	al.,Oakley
R2756	T13522	T13521	amod	central,system
R2757	T13662	T13659	nummod	1995,Oakley
R2758	T13663	T13659	punct	),Oakley
R2759	T13664	T13625	punct	.,showed
R276	T1295	T1264	nmod	et,Ernfors
R2760	T13523	T13521	amod	nervous,system
R2761	T13666	T13667	nsubj	Ringstedt,argue
R2762	T13524	T13506	punct	", ",altered
R2763	T13668	T13669	advmod	et,al.
R2764	T13669	T13666	advmod	al.,Ringstedt
R2765	T13525	T13526	det	the,course
R2766	T13670	T13666	punct	(,Ringstedt
R2767	T13671	T13666	npadvmod	1997,Ringstedt
R2768	T13672	T13666	punct	),Ringstedt
R2769	T13673	T13674	mark	that,disrupts
R277	T1296	T1264	nmod	al.,Ernfors
R2770	T13526	T13506	nsubjpass	course,altered
R2771	T13527	T13526	prep	of,course
R2772	T13674	T13667	ccomp	disrupts,argue
R2773	T13675	T13676	mark	while,navigate
R2774	T13528	T13529	det	the,afferents
R2775	T13676	T13674	advcl	navigate,disrupts
R2776	T13529	T13527	pobj	afferents,of
R2777	T13530	T13529	amod	proprioceptive,afferents
R2778	T13531	T13506	auxpass	are,altered
R2779	T13677	T13678	amod	central,axons
R278	T1297	T1264	nummod	2002,Ernfors
R2780	T13678	T13676	nsubj	axons,navigate
R2781	T13532	T13506	cc	and,altered
R2782	T13679	T13678	amod	sensory,axons
R2783	T13680	T13676	aux	may,navigate
R2784	T13681	T13676	advmod	still,navigate
R2785	T13533	T13506	conj	directed,altered
R2786	T13682	T13676	advmod	properly,navigate
R2787	T13683	T13676	prep	in,navigate
R2788	T13534	T13533	prep	towards,directed
R2789	T13684	T13685	det	the,absence
R279	T1298	T1264	punct	),Ernfors
R2790	T13535	T13536	det	the,regions
R2791	T13685	T13683	pobj	absence,in
R2792	T13686	T13685	prep	of,absence
R2793	T13687	T13686	pobj	NT,of
R2794	T13688	T13687	punct	-,NT
R2795	T13689	T13687	nummod	3,NT
R2796	T13690	T13674	punct	", ",disrupts
R2797	T13691	T13692	amod	ectopic,expression
R2798	T13692	T13674	nsubj	expression,disrupts
R2799	T13536	T13534	pobj	regions,towards
R28	T457	T456	pobj	examination,for
R280	T1299	T1213	punct	.,display
R2800	T13693	T13692	prep	of,expression
R2801	T13694	T13693	pobj	NT,of
R2802	T13695	T13694	punct	-,NT
R2803	T13537	T13536	prep	with,regions
R2804	T13696	T13694	nummod	3,NT
R2805	T13697	T13698	poss	their,targeting
R2806	T13698	T13674	dobj	targeting,disrupts
R2807	T13538	T13539	amod	high,levels
R2808	T13699	T13667	punct	.,argue
R2809	T13539	T13537	pobj	levels,with
R281	T1301	T1302	nsubjpass	NT,expressed
R2810	T13701	T13702	advmod	Recently,suggested
R2811	T13703	T13702	punct	", ",suggested
R2812	T13540	T13539	prep	of,levels
R2813	T13704	T13705	det	another,member
R2814	T13705	T13702	nsubjpass	member,suggested
R2815	T13706	T13705	prep	of,member
R2816	T13541	T13542	amod	ectopic,expression
R2817	T13707	T13708	det	the,family
R2818	T13708	T13706	pobj	family,of
R2819	T13709	T13708	compound	neurotrophin,family
R282	T1303	T1301	punct	-,NT
R2820	T13542	T13540	pobj	expression,of
R2821	T13710	T13705	punct	", ",member
R2822	T13711	T13705	appos	BDNF,member
R2823	T13712	T13702	punct	", ",suggested
R2824	T13543	T13542	nmod	NT,expression
R2825	T13713	T13702	aux	has,suggested
R2826	T13714	T13702	auxpass	been,suggested
R2827	T13715	T13716	aux	to,act
R2828	T13544	T13543	punct	-,NT
R2829	T13716	T13702	xcomp	act,suggested
R283	T1304	T1301	nummod	3,NT
R2830	T13717	T13716	prep	as,act
R2831	T13545	T13543	nummod	3,NT
R2832	T13546	T13536	prep	in,regions
R2833	T13547	T13548	det	the,cord
R2834	T13718	T13719	det	a,chemoattractant
R2835	T13548	T13546	pobj	cord,in
R2836	T13719	T13717	pobj	chemoattractant,as
R2837	T13720	T13719	prep	for,chemoattractant
R2838	T13721	T13722	amod	sensory,axons
R2839	T13549	T13548	amod	spinal,cord
R284	T1305	T1302	auxpass	is,expressed
R2840	T13722	T13723	nmod	axons,ear
R2841	T13723	T13720	pobj	ear,for
R2842	T13724	T13723	amod	innervating,ear
R2843	T13725	T13726	punct	(,Tessarollo
R2844	T13726	T13702	meta	Tessarollo,suggested
R2845	T13550	T13551	punct	(,Ringstedt
R2846	T13727	T13726	nmod	et,Tessarollo
R2847	T13728	T13726	nmod	al.,Tessarollo
R2848	T13729	T13726	nummod	2004,Tessarollo
R2849	T13730	T13726	punct	),Tessarollo
R285	T1306	T1302	prep	in,expressed
R2850	T13551	T13533	meta	Ringstedt,directed
R2851	T13731	T13702	punct	.,suggested
R2852	T13733	T13734	prep	In,rerouted
R2853	T13552	T13551	nmod	et,Ringstedt
R2854	T13735	T13736	det	a,strategy
R2855	T13553	T13551	nmod	al.,Ringstedt
R2856	T13736	T13733	pobj	strategy,In
R2857	T13737	T13738	compound	gene,replacement
R2858	T13738	T13736	compound	replacement,strategy
R2859	T13554	T13551	nummod	1997,Ringstedt
R286	T1307	T1308	det	the,cord
R2860	T13739	T13740	prep	in,driven
R2861	T13740	T13736	relcl	driven,strategy
R2862	T13741	T13739	pobj	which,in
R2863	T13555	T13551	punct	),Ringstedt
R2864	T13742	T13743	compound	BDNF,expression
R2865	T13743	T13740	nsubjpass	expression,driven
R2866	T13744	T13740	auxpass	was,driven
R2867	T13556	T13506	punct	.,altered
R2868	T13745	T13740	agent	by,driven
R2869	T13746	T13747	det	the,promoter
R287	T1308	T1306	pobj	cord,in
R2870	T13747	T13745	pobj	promoter,by
R2871	T13558	T13559	nsubj	Ringstedt,considered
R2872	T13748	T13747	nmod	NT,promoter
R2873	T13749	T13748	punct	-,NT
R2874	T13750	T13748	nummod	3,NT
R2875	T13751	T13734	punct	", ",rerouted
R2876	T13560	T13561	advmod	et,al.
R2877	T13752	T13753	amod	vestibular,axons
R2878	T13753	T13734	nsubj	axons,rerouted
R2879	T13754	T13734	prep	towards,rerouted
R288	T1309	T1308	amod	ventral,cord
R2880	T13755	T13756	amod	ectopic,sources
R2881	T13561	T13558	advmod	al.,Ringstedt
R2882	T13756	T13754	pobj	sources,towards
R2883	T13757	T13756	prep	of,sources
R2884	T13758	T13757	pobj	BDNF,of
R2885	T13562	T13563	det	the,possibility
R2886	T13759	T13756	prep	in,sources
R2887	T13760	T13761	det	the,cochlea
R2888	T13563	T13559	dobj	possibility,considered
R2889	T13761	T13759	pobj	cochlea,in
R289	T1310	T1308	amod	spinal,cord
R2890	T13762	T13763	dep	that,expressed
R2891	T13564	T13565	mark	that,play
R2892	T13763	T13756	relcl	expressed,sources
R2893	T13565	T13563	acl	play,possibility
R2894	T13764	T13763	advmod	normally,expressed
R2895	T13765	T13763	dobj	NT,expressed
R2896	T13766	T13765	punct	-,NT
R2897	T13767	T13765	nummod	3,NT
R2898	T13768	T13734	cc	and,rerouted
R2899	T13566	T13565	nsubj	NT,play
R29	T458	T457	prep	of,examination
R290	T1311	T1306	punct	", ",in
R2900	T13769	T13770	auxpass	were,innervated
R2901	T13770	T13734	conj	innervated,rerouted
R2902	T13771	T13770	neg	not,innervated
R2903	T13567	T13566	punct	-,NT
R2904	T13772	T13770	agent	by,innervated
R2905	T13773	T13774	det	these,axons
R2906	T13774	T13772	pobj	axons,by
R2907	T13568	T13566	nummod	3,NT
R2908	T13775	T13734	punct	.,rerouted
R2909	T13569	T13565	aux	may,play
R291	T1312	T1306	conj	in,in
R2910	T13777	T13778	amod	Ectopic,NT
R2911	T13778	T13779	nsubj	NT,induce
R2912	T13570	T13571	det	a,role
R2913	T13780	T13778	punct	-,NT
R2914	T13781	T13778	nummod	3,NT
R2915	T13782	T13778	acl	supplied,NT
R2916	T13571	T13565	dobj	role,play
R2917	T13889	T13867	punct	.,are
R2918	T13783	T13782	advcl	using,supplied
R2919	T13891	T13892	advmod	Previously,rescued
R292	T1313	T1314	det	the,buds
R2920	T13784	T13785	amod	osmotic,pumps
R2921	T13785	T13783	dobj	pumps,using
R2922	T13786	T13785	cc	and,pumps
R2923	T13787	T13788	npadvmod	adenovirus,mediated
R2924	T13893	T13892	punct	", ",rescued
R2925	T13788	T13790	amod	mediated,expression
R2926	T13789	T13788	punct	-,mediated
R2927	T13790	T13785	conj	expression,pumps
R2928	T13791	T13792	amod	sensory,growth
R2929	T13894	T13895	amod	normal,innervation
R293	T1314	T1312	pobj	buds,in
R2930	T13792	T13779	dobj	growth,induce
R2931	T13793	T13792	compound	axon,growth
R2932	T13794	T13779	prep	during,induce
R2933	T13895	T13892	nsubjpass	innervation,rescued
R2934	T13795	T13794	pobj	regeneration,during
R2935	T13796	T13797	punct	(,Zhang
R2936	T13797	T13779	meta	Zhang,induce
R2937	T13896	T13897	compound	motor,neuron
R2938	T13798	T13797	nmod	et,Zhang
R2939	T13799	T13797	nmod	al.,Zhang
R294	T1315	T1314	amod	developing,buds
R2940	T13800	T13797	nummod	1998,Zhang
R2941	T13897	T13895	compound	neuron,innervation
R2942	T13801	T13797	punct	", ",Zhang
R2943	T13802	T13797	nmod	Bradbury,Zhang
R2944	T13898	T13892	auxpass	was,rescued
R2945	T13803	T13797	nmod	et,Zhang
R2946	T13804	T13797	nmod	al.,Zhang
R2947	T13805	T13797	nummod	1999,Zhang
R2948	T13806	T13797	punct	", ",Zhang
R2949	T13807	T13797	nmod	Oudega,Zhang
R295	T1316	T1314	compound	limb,buds
R2950	T13808	T13797	nmod	et,Zhang
R2951	T13899	T13892	prep	in,rescued
R2952	T13809	T13797	nmod	al.,Zhang
R2953	T13810	T13797	nummod	1999,Zhang
R2954	T13900	T13901	nmod	NT,KO
R2955	T13811	T13797	punct	", ",Zhang
R2956	T13812	T13797	nmod	Ramer,Zhang
R2957	T13813	T13797	nmod	et,Zhang
R2958	T13901	T13904	compound	KO,animals
R2959	T13814	T13797	nmod	al.,Zhang
R296	T1317	T1312	punct	", ",in
R2960	T13815	T13797	nummod	2002,Zhang
R2961	T13816	T13797	punct	),Zhang
R2962	T13902	T13900	punct	-,NT
R2963	T13817	T13779	punct	", ",induce
R2964	T13818	T13779	cc	and,induce
R2965	T13819	T13779	conj	induce,induce
R2966	T13903	T13900	nummod	3,NT
R2967	T13820	T13821	amod	axonal,plasticity
R2968	T13821	T13819	dobj	plasticity,induce
R2969	T13822	T13821	prep	of,plasticity
R297	T1318	T1312	cc	and,in
R2970	T13904	T13899	pobj	animals,in
R2971	T13823	T13824	amod	corticospinal,axons
R2972	T13824	T13822	pobj	axons,of
R2973	T13825	T13819	prep	in,induce
R2974	T13905	T13892	prep	by,rescued
R2975	T13826	T13827	amod	injured,cord
R2976	T13827	T13825	pobj	cord,in
R2977	T13828	T13827	amod	adult,cord
R2978	T13906	T13905	pcomp	over-expressing,by
R2979	T13829	T13827	amod	spinal,cord
R298	T1319	T1312	conj	in,in
R2980	T13830	T13831	punct	(,Zhou
R2981	T13831	T13827	meta	Zhou,cord
R2982	T13907	T13906	dobj	NT,over-expressing
R2983	T13832	T13831	nmod	et,Zhou
R2984	T13833	T13831	nmod	al.,Zhou
R2985	T13834	T13831	nummod	2003,Zhou
R2986	T13908	T13907	punct	-,NT
R2987	T13835	T13831	punct	),Zhou
R2988	T13836	T13827	punct	", ",cord
R2989	T13909	T13907	nummod	3,NT
R299	T1320	T1321	amod	intrafusal,fibers
R2990	T13837	T13838	advmod	where,cross
R2991	T13838	T13827	relcl	cross,cord
R2992	T13910	T13906	advmod	selectively,over-expressing
R2993	T13839	T13840	det	the,axons
R2994	T13840	T13838	nsubj	axons,cross
R2995	T13841	T13840	amod	sprouting,axons
R2996	T13911	T13906	prep	in,over-expressing
R2997	T13842	T13840	prep	from,axons
R2998	T13843	T13844	det	the,site
R2999	T13844	T13842	pobj	site,from
R3	T430	T428	nummod	3,NT
R30	T459	T460	poss	their,growth
R300	T1321	T1319	pobj	fibers,in
R3000	T13845	T13844	amod	intact,site
R3001	T13912	T13913	poss	their,muscles
R3002	T13846	T13847	det	the,midline
R3003	T13847	T13838	dobj	midline,cross
R3004	T13848	T13838	prep	towards,cross
R3005	T13913	T13911	pobj	muscles,in
R3006	T13849	T13850	det	the,source
R3007	T13850	T13848	pobj	source,towards
R3008	T13914	T13915	punct	(,Wright
R3009	T13851	T13850	nmod	NT,source
R301	T1322	T1321	compound	bag,fibers
R3010	T13852	T13851	punct	-,NT
R3011	T13915	T13892	meta	Wright,rescued
R3012	T13853	T13851	nummod	3,NT
R3013	T13854	T13838	prep	on,cross
R3014	T13916	T13915	nmod	et,Wright
R3015	T13855	T13856	det	the,side
R3016	T13856	T13854	pobj	side,on
R3017	T13857	T13856	compound	lesion,side
R3018	T13917	T13915	nmod	al.,Wright
R3019	T13858	T13856	prep	of,side
R302	T1323	T1321	prep	of,fibers
R3020	T13859	T13860	det	the,cord
R3021	T13860	T13858	pobj	cord,of
R3022	T13918	T13915	nummod	1997,Wright
R3023	T13861	T13860	amod	spinal,cord
R3024	T13862	T13779	punct	.,induce
R3025	T13919	T13915	punct	),Wright
R3026	T13864	T13865	poss	Our,results
R3027	T13865	T13867	nsubj	results,are
R3028	T13866	T13865	amod	present,results
R3029	T13920	T13892	punct	.,rescued
R303	T1324	T1325	compound	muscle,spindles
R3030	T13868	T13867	prep	in,are
R3031	T13869	T13868	pobj	agreement,in
R3032	T13922	T13923	nsubj	It,appears
R3033	T13870	T13869	prep	with,agreement
R3034	T13871	T13872	det	these,observations
R3035	T13872	T13870	pobj	observations,with
R3036	T13873	T13867	punct	", ",are
R3037	T13924	T13925	mark	that,is
R3038	T13874	T13867	cc	and,are
R3039	T13875	T13867	conj	provide,are
R304	T1325	T1323	pobj	spindles,of
R3040	T13876	T13877	amod	further,evidence
R3041	T13877	T13875	dobj	evidence,provide
R3042	T13925	T13923	ccomp	is,appears
R3043	T13878	T13879	mark	that,acts
R3044	T13879	T13877	acl	acts,evidence
R3045	T13880	T13879	nsubj	NT,acts
R3046	T13926	T13927	amod	peripheral,NT
R3047	T13881	T13880	punct	-,NT
R3048	T13882	T13880	nummod	3,NT
R3049	T13883	T13879	prep	as,acts
R305	T1326	T1302	advmod	later,expressed
R3050	T13927	T13925	nsubj	NT,is
R3051	T13884	T13885	det	a,chemoattractant
R3052	T13885	T13883	pobj	chemoattractant,as
R3053	T13886	T13879	prep	for,acts
R3054	T13887	T13888	amod	sensory,afferents
R3055	T13888	T13886	pobj	afferents,for
R3056	T13928	T13927	punct	-,NT
R3057	T13929	T13927	nummod	3,NT
R3058	T13995	T13994	cc	and,Chen
R3059	T13930	T13927	advmod	alone,NT
R306	T1327	T1326	prep	in,later
R3060	T13996	T13994	conj	Frank,Chen
R3061	T13997	T13996	nummod	1999,Frank
R3062	T13998	T13996	punct	),Frank
R3063	T13999	T13975	punct	.,raised
R3064	T13931	T13925	acomp	sufficient,is
R3065	T14001	T14002	nsubj	Assays,be
R3066	T13932	T13931	prep	for,sufficient
R3067	T14003	T14004	aux	to,determine
R3068	T14004	T14001	advcl	determine,Assays
R3069	T13933	T13932	pobj	rescuing,for
R307	T1328	T1327	pobj	development,in
R3070	T14005	T14006	mark	whether,is
R3071	T14006	T14004	ccomp	is,determine
R3072	T14007	T14008	det	any,NT
R3073	T13934	T13935	amod	proprioceptive,neurons
R3074	T14008	T14006	nsubj	NT,is
R3075	T14009	T14008	punct	-,NT
R3076	T13935	T13933	dobj	neurons,rescuing
R3077	T14010	T14008	nummod	3,NT
R3078	T14011	T14006	acomp	present,is
R3079	T14012	T14006	prep	in,is
R308	T1329	T1330	punct	(,Copray
R3080	T13936	T13933	prep	in,rescuing
R3081	T14013	T14014	det	the,horns
R3082	T14014	T14012	pobj	horns,in
R3083	T14015	T14014	amod	ventral,horns
R3084	T13937	T13938	nmod	NT,KO
R3085	T14016	T14014	prep	of,horns
R3086	T14017	T14018	det	these,mice
R3087	T14018	T14016	pobj	mice,of
R3088	T13938	T13941	compound	KO,animals
R3089	T14019	T14002	aux	would,be
R309	T1330	T1302	meta	Copray,expressed
R3090	T13939	T13937	punct	-,NT
R3091	T14020	T14002	acomp	informative,be
R3092	T13940	T13937	nummod	3,NT
R3093	T14021	T14002	punct	.,be
R3094	T13941	T13936	pobj	animals,in
R3095	T14023	T14024	advmod	Recently,reported
R3096	T14025	T14024	punct	", ",reported
R3097	T13942	T13933	cc	and,rescuing
R3098	T14026	T14024	nsubj	Patel,reported
R3099	T14027	T14028	advmod	et,al.
R31	T460	T458	pobj	growth,of
R310	T1331	T1330	cc	and,Copray
R3100	T13943	T13944	amod	proper,pathfinding
R3101	T14028	T14026	advmod	al.,Patel
R3102	T14029	T14026	punct	(,Patel
R3103	T14030	T14026	npadvmod	2003,Patel
R3104	T14031	T14026	punct	),Patel
R3105	T14032	T14033	poss	their,observations
R3106	T14033	T14024	dobj	observations,reported
R3107	T13944	T13933	conj	pathfinding,rescuing
R3108	T14034	T14033	prep	on,observations
R3109	T14035	T14036	nmod	Bax,KO
R311	T1332	T1330	conj	Brouwer,Copray
R3110	T14036	T14042	compound	KO,mice
R3111	T13945	T13944	amod	axonal,pathfinding
R3112	T14037	T14035	punct	/,Bax
R3113	T14038	T14035	appos	NT,Bax
R3114	T13946	T13944	prep	in,pathfinding
R3115	T14039	T14038	punct	-,NT
R3116	T14040	T14038	nummod	3,NT
R3117	T14041	T14036	amod	double,KO
R3118	T14042	T14034	pobj	mice,on
R3119	T14043	T14044	nsubj	they,bred
R312	T1333	T1332	nummod	1994,Brouwer
R3120	T13947	T13948	det	the,cord
R3121	T14044	T14042	advcl	bred,mice
R3122	T14045	T14024	punct	.,reported
R3123	T13948	T13946	pobj	cord,in
R3124	T14047	T14048	poss	Their,results
R3125	T14048	T14049	nsubj	results,are
R3126	T14050	T14049	advmod	significantly,are
R3127	T13949	T13948	amod	spinal,cord
R3128	T14051	T14049	acomp	different,are
R3129	T14052	T14051	prep	from,different
R313	T1334	T1332	punct	;,Brouwer
R3130	T14053	T14052	pobj	ours,from
R3131	T13950	T13923	punct	.,appears
R3132	T14054	T14049	punct	.,are
R3133	T14056	T14057	nsubj	They,see
R3134	T13952	T13953	advmod	However,is
R3135	T14058	T14059	det	no,afferents
R3136	T14059	T14057	dobj	afferents,see
R3137	T14060	T14059	amod	proprioceptive,afferents
R3138	T13954	T13953	punct	", ",is
R3139	T14061	T14057	prep	in,see
R314	T1335	T1332	conj	Fariñas,Brouwer
R3140	T14062	T14063	det	the,periphery
R3141	T14063	T14061	pobj	periphery,in
R3142	T14064	T14063	prep	of,periphery
R3143	T13955	T13953	nsubj	it,is
R3144	T14065	T14066	det	the,knockouts
R3145	T14066	T14064	pobj	knockouts,of
R3146	T14067	T14066	amod	double,knockouts
R3147	T13956	T13953	acomp	unclear,is
R3148	T14068	T14057	cc	and,see
R3149	T14069	T14057	conj	note,see
R315	T1336	T1335	nmod	et,Fariñas
R3150	T14070	T14071	mark	that,terminate
R3151	T13957	T13958	mark	whether,is
R3152	T14071	T14069	ccomp	terminate,note
R3153	T14072	T14073	amod	central,afferents
R3154	T14073	T14071	nsubj	afferents,terminate
R3155	T14074	T14073	amod	proprioceptive,afferents
R3156	T14075	T14071	prep	in,terminate
R3157	T14076	T14077	det	the,cord
R3158	T14077	T14075	pobj	cord,in
R3159	T14078	T14077	amod	intermediate,cord
R316	T1337	T1335	nmod	al.,Fariñas
R3160	T14079	T14077	amod	spinal,cord
R3161	T13958	T13953	ccomp	is,is
R3162	T14080	T14071	prep	without,terminate
R3163	T14081	T14080	pcomp	extending,without
R3164	T14082	T14081	advmod	ventrally,extending
R3165	T13959	T13958	nsubj	NT,is
R3166	T14083	T14057	punct	.,see
R3167	T14085	T14086	poss	Their,observations
R3168	T13960	T13959	punct	-,NT
R3169	T14086	T14087	nsubjpass	observations,based
R317	T1338	T1335	nummod	1996,Fariñas
R3170	T14088	T14087	auxpass	are,based
R3171	T13961	T13959	nummod	3,NT
R3172	T14089	T14087	prep	on,based
R3173	T14090	T14091	compound	PV,immunostaining
R3174	T14091	T14089	pobj	immunostaining,on
R3175	T13962	T13958	acomp	absent,is
R3176	T14092	T14091	cc	and,immunostaining
R3177	T14093	T14094	compound	DiI,labeling
R3178	T14094	T14091	conj	labeling,immunostaining
R3179	T14095	T14091	prep	of,immunostaining
R318	T1339	T1335	punct	;,Fariñas
R3180	T14096	T14097	det	the,nerves
R3181	T13963	T13962	prep	from,absent
R3182	T14097	T14095	pobj	nerves,of
R3183	T14098	T14097	amod	peripheral,nerves
R3184	T14099	T14087	punct	.,based
R3185	T13964	T13965	det	the,cords
R3186	T13965	T13963	pobj	cords,from
R3187	T14101	T14102	nsubj	We,noted
R3188	T13966	T13965	amod	ventral,cords
R3189	T14103	T14104	mark	that,is
R319	T1340	T1335	conj	Tojo,Fariñas
R3190	T14104	T14102	ccomp	is,noted
R3191	T14105	T14106	compound	PV,immunolabeling
R3192	T13967	T13965	amod	spinal,cords
R3193	T14106	T14104	nsubj	immunolabeling,is
R3194	T14107	T14104	acomp	diminished,is
R3195	T14108	T14104	prep	in,is
R3196	T13968	T13965	prep	of,cords
R3197	T14109	T14110	poss	our,KOs
R3198	T13969	T13970	det	these,animals
R3199	T13970	T13968	pobj	animals,of
R32	T461	T460	compound	axon,growth
R320	T1341	T1340	nmod	et,Tojo
R3200	T13971	T13953	punct	.,is
R3201	T14110	T14108	pobj	KOs,in
R3202	T13973	T13974	det	The,possibility
R3203	T14111	T14110	nmod	Bax,KOs
R3204	T14112	T14111	punct	/,Bax
R3205	T14113	T14111	appos	NT,Bax
R3206	T14114	T14113	punct	-,NT
R3207	T14115	T14113	nummod	3,NT
R3208	T14116	T14110	amod	double,KOs
R3209	T14117	T14102	punct	.,noted
R321	T1342	T1340	nmod	al.,Tojo
R3210	T14119	T14120	prep	In,noted
R3211	T13974	T13975	nsubjpass	possibility,raised
R3212	T14120	T14129	ccomp	noted,reveal
R3213	T14121	T14122	amod	various,manipulations
R3214	T13976	T13975	aux	has,raised
R3215	T14122	T14119	pobj	manipulations,In
R3216	T14123	T14122	prep	of,manipulations
R3217	T14124	T14125	det	the,neurotrophins
R3218	T14125	T14123	pobj	neurotrophins,of
R3219	T14126	T14120	nsubjpass	it,noted
R322	T1343	T1340	nummod	1996,Tojo
R3220	T13977	T13975	auxpass	been,raised
R3221	T14127	T14120	aux	has,noted
R3222	T14128	T14120	auxpass	been,noted
R3223	T13978	T13979	mark	that,transport
R3224	T14130	T14131	mark	that,are
R3225	T14131	T14120	ccomp	are,noted
R3226	T14132	T14133	amod	molecular,markers
R3227	T13979	T13975	ccomp	transport,raised
R3228	T14133	T14131	nsubj	markers,are
R3229	T14134	T14133	prep	for,markers
R323	T1344	T1340	punct	),Tojo
R3230	T14135	T14136	amod	proprioceptive,axons
R3231	T13980	T13981	compound	motor,neurons
R3232	T14136	T14134	pobj	axons,for
R3233	T14137	T14138	amod	such,as
R3234	T14138	T14136	prep	as,axons
R3235	T13981	T13979	nsubj	neurons,transport
R3236	T14139	T14138	pobj	PV,as
R3237	T14140	T14133	cc	or,markers
R3238	T14141	T14142	nmod	calcitonin,peptide
R3239	T14142	T14133	conj	peptide,markers
R324	T1345	T1302	punct	.,expressed
R3240	T13982	T13979	aux	may,transport
R3241	T14143	T14144	npadvmod	gene,related
R3242	T14144	T14142	amod	related,peptide
R3243	T14145	T14144	punct	-,related
R3244	T14146	T14142	prep	for,peptide
R3245	T14147	T14148	nmod	nerve,axons
R3246	T13983	T13979	advmod	retrogradely,transport
R3247	T14148	T14146	pobj	axons,for
R3248	T14149	T14150	compound	growth,factor
R3249	T14150	T14151	npadvmod	factor,responsive
R325	T1347	T1348	advmod	When,contact
R3250	T14151	T14148	amod	responsive,axons
R3251	T13984	T13979	dobj	NT,transport
R3252	T14152	T14151	punct	–,responsive
R3253	T14153	T14131	acomp	compromised,are
R3254	T14154	T14155	punct	(,Ringstedt
R3255	T13985	T13984	punct	-,NT
R3256	T14155	T14120	meta	Ringstedt,noted
R3257	T14156	T14155	nmod	et,Ringstedt
R3258	T14157	T14155	nmod	al.,Ringstedt
R3259	T14158	T14155	nummod	1997,Ringstedt
R326	T1348	T1351	advcl	contact,induce
R3260	T14159	T14155	punct	;,Ringstedt
R3261	T14160	T14155	nmod	Patel,Ringstedt
R3262	T13986	T13984	nummod	3,NT
R3263	T14161	T14155	nmod	et,Ringstedt
R3264	T14162	T14155	nmod	al.,Ringstedt
R3265	T14163	T14155	nummod	2000,Ringstedt
R3266	T13987	T13979	prep	in,transport
R3267	T14164	T14155	punct	),Ringstedt
R3268	T14165	T14129	punct	", ",reveal
R3269	T14166	T14129	advmod	thus,reveal
R327	T1349	T1350	amod	sensory,axons
R3270	T13988	T13987	pobj	muscle,in
R3271	T14167	T14168	compound	PV,immunostaining
R3272	T14168	T14129	nsubj	immunostaining,reveal
R3273	T13989	T13979	prep	to,transport
R3274	T14169	T14168	prep	in,immunostaining
R3275	T14170	T14171	nmod	Bax,KOs
R3276	T14171	T14169	pobj	KOs,in
R3277	T13990	T13991	det	the,cord
R3278	T14172	T14170	punct	/,Bax
R3279	T14173	T14170	appos	NT,Bax
R328	T1350	T1348	nsubj	axons,contact
R3280	T14174	T14173	punct	-,NT
R3281	T13991	T13989	pobj	cord,to
R3282	T14175	T14173	nummod	3,NT
R3283	T14176	T14171	amod	double,KOs
R3284	T14177	T14129	aux	can,reveal
R3285	T13992	T13991	amod	spinal,cord
R3286	T14178	T14129	neg	not,reveal
R3287	T14179	T14180	det	the,extent
R3288	T14180	T14129	dobj	extent,reveal
R3289	T13993	T13994	punct	(,Chen
R329	T1352	T1353	amod	developing,myotubes
R3290	T14181	T14180	prep	of,extent
R3291	T14182	T14183	amod	proprioceptive,axons
R3292	T14183	T14181	pobj	axons,of
R3293	T13994	T13975	meta	Chen,raised
R3294	T14184	T14183	prep	in,axons
R3295	T14185	T14186	det	the,periphery
R3296	T14186	T14184	pobj	periphery,in
R3297	T14206	T14202	prep	in,expressing
R3298	T14187	T14129	punct	.,reveal
R3299	T14189	T14190	compound	Seventy,three
R33	T462	T455	prep	in,allows
R330	T1353	T1348	dobj	myotubes,contact
R3300	T14190	T14192	nummod	three,percent
R3301	T14207	T14208	det	the,DRG
R3302	T14191	T14190	punct	-,three
R3303	T14192	T14193	nsubjpass	percent,reported
R3304	T14208	T14206	pobj	DRG,in
R3305	T14194	T14192	prep	of,percent
R3306	T14195	T14196	advmod	retrogradely,labeled
R3307	T14209	T14208	amod	adult,DRG
R3308	T14196	T14197	amod	labeled,afferents
R3309	T14210	T14208	compound	rat,DRG
R331	T1354	T1351	punct	", ",induce
R3310	T14197	T14194	pobj	afferents,of
R3311	T14198	T14199	compound	gastrocnemius,muscle
R3312	T14199	T14197	compound	muscle,afferents
R3313	T14200	T14193	auxpass	were,reported
R3314	T14201	T14202	aux	to,expressing
R3315	T14202	T14193	xcomp	expressing,reported
R3316	T14211	T14193	punct	", ",reported
R3317	T14203	T14202	aux	be,expressing
R3318	T14204	T14205	compound	TrkC,RNA
R3319	T14212	T14213	mark	although,represent
R332	T1355	T1351	nsubj	they,induce
R3320	T14205	T14202	dobj	RNA,expressing
R3321	T14213	T14193	advcl	represent,reported
R3322	T14214	T14213	nsubj	some,represent
R3323	T14215	T14214	prep	of,some
R3324	T14312	T14309	nsubj	findings,suggest
R3325	T14313	T14314	det	a,role
R3326	T14216	T14215	pobj	these,of
R3327	T14314	T14309	dobj	role,suggest
R3328	T14217	T14214	punct	(,some
R3329	T14315	T14314	prep	for,role
R333	T1356	T1357	compound	muscle,spindle
R3330	T14316	T14315	pobj	NT,for
R3331	T14317	T14316	punct	-,NT
R3332	T14318	T14316	nummod	3,NT
R3333	T14218	T14219	advmod	about,10
R3334	T14319	T14314	prep	in,role
R3335	T14320	T14319	pobj	initiation,in
R3336	T14219	T14220	nummod	10,%
R3337	T14321	T14320	prep	of,initiation
R3338	T14322	T14323	compound	muscle,innervation
R3339	T14323	T14321	pobj	innervation,of
R334	T1357	T1358	compound	spindle,differentiation
R3340	T14220	T14214	appos	%,some
R3341	T14324	T14320	cc	and,initiation
R3342	T14325	T14326	compound	spindle,differentiation
R3343	T14326	T14320	conj	differentiation,initiation
R3344	T14221	T14214	punct	),some
R3345	T14327	T14326	prep	by,differentiation
R3346	T14328	T14329	det	the,axons
R3347	T14329	T14327	pobj	axons,by
R3348	T14222	T14213	aux	may,represent
R3349	T14330	T14329	amod	proprioceptive,axons
R335	T1358	T1351	dobj	differentiation,induce
R3350	T14331	T14309	punct	.,suggest
R3351	T14223	T14224	amod	cutaneous,innervation
R3352	T14333	T14334	nsubj	Patel,examined
R3353	T14224	T14213	dobj	innervation,represent
R3354	T14335	T14336	advmod	et,al.
R3355	T14336	T14333	advmod	al.,Patel
R3356	T14337	T14333	punct	(,Patel
R3357	T14225	T14226	punct	(,McMahon
R3358	T14338	T14333	npadvmod	2003,Patel
R3359	T14339	T14333	punct	),Patel
R336	T1359	T1351	punct	", ",induce
R3360	T14340	T14341	npadvmod	DiI,labeled
R3361	T14226	T14193	meta	McMahon,reported
R3362	T14341	T14343	amod	labeled,axons
R3363	T14342	T14341	punct	-,labeled
R3364	T14343	T14334	dobj	axons,examined
R3365	T14344	T14343	amod	central,axons
R3366	T14345	T14343	compound	DRG,axons
R3367	T14346	T14343	prep	in,axons
R3368	T14227	T14226	nmod	et,McMahon
R3369	T14347	T14348	det	the,cord
R337	T1360	T1351	advcl	forming,induce
R3370	T14348	T14346	pobj	cord,in
R3371	T14349	T14348	amod	spinal,cord
R3372	T14228	T14226	nmod	al.,McMahon
R3373	T14350	T14348	prep	of,cord
R3374	T14351	T14352	nummod	three,E17
R3375	T14352	T14350	pobj	E17,of
R3376	T14229	T14226	nummod	1994,McMahon
R3377	T14353	T14352	cc	and,E17
R3378	T14354	T14355	nummod	two,P0
R3379	T14355	T14356	compound	P0,cases
R338	T1361	T1362	npadvmod	ring,like
R3380	T14230	T14226	punct	),McMahon
R3381	T14356	T14352	conj	cases,E17
R3382	T14357	T14334	punct	", ",examined
R3383	T14231	T14193	punct	.,reported
R3384	T14358	T14334	cc	and,examined
R3385	T14359	T14334	conj	report,examined
R3386	T14360	T14361	mark	that,stop
R3387	T14233	T14234	advmod	Presently,is
R3388	T14361	T14359	ccomp	stop,report
R3389	T14362	T14363	amod	central,axons
R339	T1362	T1364	amod	like,endings
R3390	T14363	T14361	nsubj	axons,stop
R3391	T14364	T14363	amod	proprioceptive,axons
R3392	T14235	T14234	punct	", ",is
R3393	T14365	T14361	prep	in,stop
R3394	T14236	T14234	nsubj	it,is
R3395	T14366	T14367	det	the,laminae
R3396	T14367	T14365	pobj	laminae,in
R3397	T14237	T14234	neg	not,is
R3398	T14368	T14367	amod	intermediate,laminae
R3399	T14369	T14361	punct	", ",stop
R34	T463	T464	det	the,absence
R340	T1363	T1362	punct	-,like
R3400	T14370	T14371	neg	never,entering
R3401	T14238	T14234	acomp	clear,is
R3402	T14371	T14361	advcl	entering,stop
R3403	T14372	T14373	det	the,cord
R3404	T14373	T14371	dobj	cord,entering
R3405	T14239	T14240	mark	whether,made
R3406	T14374	T14373	amod	ventral,cord
R3407	T14375	T14334	punct	.,examined
R3408	T14240	T14234	advcl	made,is
R3409	T14377	T14378	nsubj	We,examined
R341	T1364	T1360	dobj	endings,forming
R3410	T14241	T14242	compound	TrkC,protein
R3411	T14379	T14378	aux	have,examined
R3412	T14380	T14381	nummod	nine,cases
R3413	T14242	T14240	nsubjpass	protein,made
R3414	T14381	T14378	dobj	cases,examined
R3415	T14382	T14383	nmod	Bax,KO
R3416	T14383	T14381	compound	KO,cases
R3417	T14384	T14382	punct	/,Bax
R3418	T14385	T14382	appos	NT,Bax
R3419	T14386	T14385	punct	-,NT
R342	T1365	T1364	amod	spiral,endings
R3420	T14387	T14385	nummod	3,NT
R3421	T14243	T14240	auxpass	is,made
R3422	T14388	T14383	amod	double,KO
R3423	T14389	T14378	punct	", ",examined
R3424	T14390	T14378	cc	and,examined
R3425	T14244	T14240	advmod	also,made
R3426	T14391	T14392	advmod	often,gives
R3427	T14392	T14378	conj	gives,examined
R3428	T14393	T14394	amod	incomplete,labeling
R3429	T14245	T14240	agent	by,made
R343	T1366	T1364	compound	nerve,endings
R3430	T14394	T14392	nsubj	labeling,gives
R3431	T14395	T14394	compound	DiI,labeling
R3432	T14396	T14397	det	the,impression
R3433	T14246	T14247	amod	cutaneous,afferents
R3434	T14397	T14392	dobj	impression,gives
R3435	T14398	T14399	mark	that,are
R3436	T14399	T14397	acl	are,impression
R3437	T14247	T14245	pobj	afferents,by
R3438	T14400	T14399	expl	there,are
R3439	T14401	T14402	det	no,axons
R344	T1367	T1360	prep	around,forming
R3440	T14248	T14240	cc	and,made
R3441	T14402	T14399	attr	axons,are
R3442	T14403	T14402	acl	reaching,axons
R3443	T14404	T14405	det	the,cord
R3444	T14249	T14250	mark	if,so
R3445	T14405	T14403	dobj	cord,reaching
R3446	T14406	T14405	amod	ventral,cord
R3447	T14407	T14405	amod	spinal,cord
R3448	T14250	T14251	advcl	so,expressed
R3449	T14408	T14392	punct	.,gives
R345	T1368	T1367	pobj	them,around
R3450	T14251	T14240	conj	expressed,made
R3451	T14410	T14411	nsubj	We,seen
R3452	T14412	T14411	aux	have,seen
R3453	T14252	T14251	prep	at,expressed
R3454	T14413	T14411	advmod	also,seen
R3455	T14414	T14411	dobj	cases,seen
R3456	T14415	T14414	amod	similar,cases
R3457	T14253	T14254	det	what,stage
R3458	T14416	T14415	prep	to,similar
R3459	T14417	T14416	pobj	theirs,to
R346	T1369	T1351	punct	.,induce
R3460	T14254	T14252	pcomp	stage,at
R3461	T14255	T14254	prep	in,stage
R3462	T14256	T14255	pobj	development,in
R3463	T14418	T14419	punct	(,4
R3464	T14419	T14414	parataxis	4,cases
R3465	T14420	T14419	nsubj	n,4
R3466	T14257	T14258	det	this,receptor
R3467	T14421	T14419	punct	=,4
R3468	T14422	T14419	punct	),4
R3469	T14423	T14411	punct	", ",seen
R347	T1371	T1372	prep	In,lead
R3470	T14424	T14411	cc	but,seen
R3471	T14425	T14426	prep	at,have
R3472	T14426	T14411	conj	have,seen
R3473	T14258	T14251	nsubjpass	receptor,expressed
R3474	T14427	T14428	amod	higher,magnification
R3475	T14428	T14425	pobj	magnification,at
R3476	T14429	T14430	det	these,axons
R3477	T14259	T14251	auxpass	is,expressed
R3478	T14430	T14426	nsubj	axons,have
R3479	T14431	T14426	aux	did,have
R348	T1373	T1374	det	the,embryo
R3480	T14432	T14426	neg	not,have
R3481	T14260	T14251	agent	by,expressed
R3482	T14433	T14434	amod	terminal,boutons
R3483	T14434	T14426	dobj	boutons,have
R3484	T14435	T14426	cc	and,have
R3485	T14261	T14262	amod	cutaneous,axons
R3486	T14436	T14437	auxpass	were,labeled
R3487	T14437	T14426	conj	labeled,have
R3488	T14262	T14260	pobj	axons,by
R3489	T14438	T14437	neg	not,labeled
R349	T1374	T1371	pobj	embryo,In
R3490	T14439	T14437	advmod	completely,labeled
R3491	T14440	T14426	punct	.,have
R3492	T14263	T14234	punct	.,is
R3493	T14442	T14443	advmod	However,was
R3494	T14265	T14266	prep	Based,think
R3495	T14444	T14443	punct	", ",was
R3496	T14445	T14443	prep	with,was
R3497	T14446	T14447	amod	complete,fills
R3498	T14447	T14445	pobj	fills,with
R3499	T14267	T14265	prep	on,Based
R35	T464	T462	pobj	absence,in
R350	T1375	T1374	compound	chicken,embryo
R3500	T14448	T14449	punct	(,5
R3501	T14449	T14447	parataxis	5,fills
R3502	T14450	T14449	nsubj	n,5
R3503	T14268	T14269	det	the,evidence
R3504	T14451	T14449	punct	=,5
R3505	T14452	T14449	punct	),5
R3506	T14269	T14267	pobj	evidence,on
R3507	T14453	T14443	punct	", ",was
R3508	T14270	T14269	amod	available,evidence
R3509	T14454	T14443	nsubj	it,was
R351	T1376	T1372	punct	", ",lead
R3510	T14455	T14443	acomp	possible,was
R3511	T14271	T14269	acl	showing,evidence
R3512	T14456	T14457	aux	to,trace
R3513	T14457	T14443	xcomp	trace,was
R3514	T14458	T14459	det	these,axons
R3515	T14272	T14273	mark	that,eliminated
R3516	T14459	T14457	dobj	axons,trace
R3517	T14460	T14457	prep	into,trace
R3518	T14461	T14462	det	the,midline
R3519	T14462	T14460	pobj	midline,into
R352	T1377	T1378	compound	limb,ablations
R3520	T14463	T14462	amod	ventral,midline
R3521	T14464	T14460	cc	and,into
R3522	T14465	T14460	conj	across,into
R3523	T14273	T14271	ccomp	eliminated,showing
R3524	T14466	T14465	prep	to,across
R3525	T14467	T14468	det	the,side
R3526	T14274	T14275	det	all,neurons
R3527	T14468	T14466	pobj	side,to
R3528	T14469	T14468	amod	contralateral,side
R3529	T14470	T14457	punct	", ",trace
R353	T1378	T1372	nsubj	ablations,lead
R3530	T14275	T14273	nsubjpass	neurons,eliminated
R3531	T14471	T14457	cc	and,trace
R3532	T14472	T14457	conj	visualize,trace
R3533	T14473	T14474	amod	terminal,boutons
R3534	T14276	T14275	amod	proprioceptive,neurons
R3535	T14474	T14472	dobj	boutons,visualize
R3536	T14475	T14474	prep	at,boutons
R3537	T14476	T14477	poss	their,tips
R3538	T14277	T14273	auxpass	are,eliminated
R3539	T14477	T14475	pobj	tips,at
R354	T1379	T1378	cc	or,ablations
R3540	T14478	T14479	punct	(,see
R3541	T14278	T14273	prep	in,eliminated
R3542	T14479	T14472	parataxis	see,visualize
R3543	T14480	T14481	compound	Figure,3C
R3544	T14481	T14479	dobj	3C,see
R3545	T14279	T14280	npadvmod	NT,null
R3546	T14482	T14479	punct	),see
R3547	T14483	T14443	punct	.,was
R3548	T14280	T14285	amod	null,mice
R3549	T14485	T14486	advmod	Previously,reported
R355	T1380	T1381	amod	anti-NT,3
R3550	T14281	T14279	punct	-,NT
R3551	T14487	T14486	punct	", ",reported
R3552	T14488	T14486	nsubj	Arber,reported
R3553	T14489	T14490	advmod	et,al.
R3554	T14282	T14279	nummod	3,NT
R3555	T14490	T14488	advmod	al.,Arber
R3556	T14491	T14488	punct	(,Arber
R3557	T14492	T14488	npadvmod	2000,Arber
R3558	T14283	T14279	cc	or,NT
R3559	T14493	T14488	punct	),Arber
R356	T1381	T1383	nummod	3,antibody
R3560	T14494	T14495	mark	that,expressed
R3561	T14495	T14486	ccomp	expressed,reported
R3562	T14284	T14279	conj	TrkC,NT
R3563	T14285	T14278	pobj	mice,in
R3564	T14496	T14495	nsubjpass	members,expressed
R3565	T14286	T14266	punct	", ",think
R3566	T14497	T14496	prep	of,members
R3567	T14498	T14499	det	the,family
R3568	T14499	T14497	pobj	family,of
R3569	T14287	T14266	nsubj	we,think
R357	T1382	T1381	punct	-,3
R3570	T14500	T14499	compound	Ets,family
R3571	T14501	T14499	prep	of,family
R3572	T14502	T14503	compound	transcription,factors
R3573	T14503	T14501	pobj	factors,of
R3574	T14504	T14496	punct	", ",members
R3575	T14505	T14496	appos	Er81,members
R3576	T14506	T14505	cc	and,Er81
R3577	T14288	T14289	mark	that,represents
R3578	T14507	T14505	conj	Pea3,Er81
R3579	T14508	T14495	punct	", ",expressed
R358	T1383	T1384	compound	antibody,injections
R3580	T14509	T14495	auxpass	are,expressed
R3581	T14289	T14266	ccomp	represents,think
R3582	T14510	T14495	agent	by,expressed
R3583	T14511	T14512	compound	DRG,neurons
R3584	T14512	T14510	pobj	neurons,by
R3585	T14290	T14291	compound	TrkC,staining
R3586	T14513	T14514	advmod	as,as
R3587	T14514	T14512	cc	as,neurons
R3588	T14291	T14289	nsubj	staining,represents
R3589	T14515	T14514	advmod	well,as
R359	T1384	T1378	conj	injections,ablations
R3590	T14516	T14517	compound	motor,neurons
R3591	T14517	T14512	conj	neurons,neurons
R3592	T14292	T14291	prep	in,staining
R3593	T14518	T14517	cc	and,neurons
R3594	T14519	T14520	poss	their,fibers
R3595	T14520	T14517	conj	fibers,neurons
R3596	T14293	T14294	det	the,nerve
R3597	T14521	T14520	compound	target,fibers
R3598	T14522	T14520	compound	muscle,fibers
R3599	T14523	T14486	punct	.,reported
R36	T465	T464	prep	of,absence
R360	T1385	T1384	prep	into,injections
R3600	T14294	T14292	pobj	nerve,in
R3601	T14295	T14294	amod	tibial,nerve
R3602	T14296	T14289	advmod	mostly,represents
R3603	T14525	T14526	nsubj	They,found
R3604	T14297	T14298	amod	proprioceptive,axons
R3605	T14527	T14528	mark	that,were
R3606	T14298	T14289	dobj	axons,represents
R3607	T14299	T14298	prep	in,axons
R3608	T14528	T14526	ccomp	were,found
R3609	T14300	T14301	det	the,vicinity
R361	T1386	T1387	compound	limb,buds
R3610	T14529	T14528	prep	in,were
R3611	T14530	T14531	det	the,cord
R3612	T14301	T14299	pobj	vicinity,in
R3613	T14531	T14529	pobj	cord,in
R3614	T14532	T14531	amod	spinal,cord
R3615	T14533	T14531	prep	of,cord
R3616	T14302	T14301	prep	of,vicinity
R3617	T14534	T14535	compound	Er81,KO
R3618	T14535	T14536	compound	KO,mice
R3619	T14303	T14304	poss	their,target
R362	T1387	T1385	pobj	buds,into
R3620	T14536	T14533	pobj	mice,of
R3621	T14537	T14528	punct	", ",were
R3622	T14538	T14539	amod	ventral,projections
R3623	T14539	T14528	nsubj	projections,were
R3624	T14540	T14539	prep	of,projections
R3625	T14541	T14542	amod	proprioceptive,axons
R3626	T14542	T14540	pobj	axons,of
R3627	T14304	T14302	pobj	target,of
R3628	T14543	T14544	advmod	mostly,absent
R3629	T14544	T14528	acomp	absent,were
R363	T1388	T1372	prep	to,lead
R3630	T14545	T14528	punct	", ",were
R3631	T14305	T14304	amod	peripheral,target
R3632	T14546	T14528	cc	and,were
R3633	T14306	T14266	punct	.,think
R3634	T14547	T14548	advmod	very,axons
R3635	T14548	T14550	nsubj	axons,made
R3636	T14549	T14548	amod	few,axons
R3637	T14550	T14528	conj	made,were
R3638	T14551	T14550	dobj	it,made
R3639	T14552	T14550	prep	to,made
R364	T1389	T1388	pobj	elimination,to
R3640	T14308	T14309	advmod	Altogether,suggest
R3641	T14553	T14554	det	the,cord
R3642	T14554	T14552	pobj	cord,to
R3643	T14555	T14554	amod	ventral,cord
R3644	T14556	T14526	punct	.,found
R3645	T14558	T14559	nsubj	Patel,note
R3646	T14310	T14309	punct	", ",suggest
R3647	T14560	T14561	advmod	et,al.
R3648	T14561	T14558	advmod	al.,Patel
R3649	T14562	T14558	punct	(,Patel
R365	T1390	T1389	prep	of,elimination
R3650	T14563	T14558	npadvmod	2003,Patel
R3651	T14311	T14312	poss	our,findings
R3652	T14564	T14558	punct	),Patel
R3653	T14565	T14566	mark	that,is
R3654	T14566	T14559	ccomp	is,note
R3655	T14567	T14568	det	the,phenotype
R3656	T14568	T14566	nsubj	phenotype,is
R3657	T14630	T14628	nmod	KO,mice
R3658	T14569	T14570	nsubj	they,observed
R3659	T14570	T14568	advcl	observed,phenotype
R366	T1391	T1392	npadvmod	TrkC,positive
R3660	T14571	T14570	prep	in,observed
R3661	T14572	T14573	poss	their,mice
R3662	T14573	T14571	pobj	mice,in
R3663	T14574	T14575	nmod	Bax,KO
R3664	T14575	T14573	compound	KO,mice
R3665	T14576	T14574	punct	/,Bax
R3666	T14577	T14574	appos	NT,Bax
R3667	T14631	T14629	punct	-,NT
R3668	T14578	T14577	punct	-,NT
R3669	T14579	T14577	nummod	3,NT
R367	T1392	T1394	amod	positive,neurons
R3670	T14580	T14575	amod	double,KO
R3671	T14632	T14629	nummod	3,NT
R3672	T14581	T14582	advmod	quite,similar
R3673	T14582	T14566	acomp	similar,is
R3674	T14583	T14582	prep	to,similar
R3675	T14584	T14583	pobj	that,to
R3676	T14585	T14584	prep	of,that
R3677	T14586	T14587	compound	Er81,KO
R3678	T14587	T14588	compound	KO,mice
R3679	T14588	T14585	pobj	mice,of
R368	T1393	T1392	punct	-,positive
R3680	T14589	T14559	punct	.,note
R3681	T14633	T14630	cc	and,KO
R3682	T14591	T14592	nsubj	They,provide
R3683	T14593	T14592	dobj	evidence,provide
R3684	T14634	T14635	nmod	Bax,KO
R3685	T14594	T14595	mark	that,induces
R3686	T14595	T14593	acl	induces,evidence
R3687	T14635	T14630	conj	KO,KO
R3688	T14596	T14595	nsubj	NT,induces
R3689	T14597	T14596	punct	-,NT
R369	T1394	T1390	pobj	neurons,of
R3690	T14598	T14596	nummod	3,NT
R3691	T14636	T14634	punct	/,Bax
R3692	T14599	T14600	compound	Er81,expression
R3693	T14600	T14595	dobj	expression,induces
R3694	T14601	T14595	prep	in,induces
R3695	T14637	T14634	appos	NT,Bax
R3696	T14602	T14603	compound	DRG,explants
R3697	T14603	T14601	pobj	explants,in
R3698	T14604	T14605	advmod	in,vitro
R3699	T14638	T14637	punct	-,NT
R37	T466	T467	nmod	NT,signaling
R370	T1395	T1389	cc	and,elimination
R3700	T14605	T14595	advmod	vitro,induces
R3701	T14606	T14592	punct	.,provide
R3702	T14639	T14637	nummod	3,NT
R3703	T14608	T14609	nsubj	Patel,report
R3704	T14610	T14611	advmod	et,al.
R3705	T14611	T14608	advmod	al.,Patel
R3706	T14640	T14635	amod	double,KO
R3707	T14612	T14608	punct	(,Patel
R3708	T14613	T14608	npadvmod	2003,Patel
R3709	T14614	T14608	punct	),Patel
R371	T1396	T1397	amod	decreased,innervation
R3710	T14641	T14609	punct	", ",report
R3711	T14615	T14616	mark	that,diminished
R3712	T14616	T14609	ccomp	diminished,report
R3713	T14617	T14618	compound	Er81,expression
R3714	T14642	T14643	mark	while,shows
R3715	T14618	T14616	nsubj	expression,diminished
R3716	T14619	T14618	compound	mRNA,expression
R3717	T14620	T14616	aux	is,diminished
R3718	T14643	T14609	advcl	shows,report
R3719	T14621	T14616	punct	(,diminished
R372	T1397	T1389	conj	innervation,elimination
R3720	T14622	T14616	cc	but,diminished
R3721	T14623	T14624	neg	not,abolished
R3722	T14644	T14645	poss	their,immunohistochemistry
R3723	T14624	T14616	conj	abolished,diminished
R3724	T14645	T14643	nsubj	immunohistochemistry,shows
R3725	T14625	T14616	punct	),diminished
R3726	T14626	T14616	prep	in,diminished
R3727	T14627	T14628	preconj	both,mice
R3728	T14628	T14626	pobj	mice,in
R3729	T14629	T14630	nmod	NT,KO
R373	T1398	T1397	prep	of,innervation
R3730	T14646	T14647	advmod	much,less
R3731	T14647	T14648	amod	less,expression
R3732	T14648	T14643	dobj	expression,shows
R3733	T14649	T14648	compound	protein,expression
R3734	T14736	T14734	pobj	cord,to
R3735	T14737	T14736	amod	ventral,cord
R3736	T14650	T14643	prep	in,shows
R3737	T14738	T14736	amod	spinal,cord
R3738	T14739	T14727	cc	and,find
R3739	T14740	T14727	conj	target,find
R374	T1399	T1400	compound	motor,neurons
R3740	T14651	T14652	det	the,mice
R3741	T14741	T14740	advmod	properly,target
R3742	T14742	T14740	prep	to,target
R3743	T14743	T14744	det	the,neurons
R3744	T14652	T14650	pobj	mice,in
R3745	T14744	T14742	pobj	neurons,to
R3746	T14745	T14744	compound	motor,neurons
R3747	T14653	T14654	amod	double,KO
R3748	T14746	T14747	punct	(,Arber
R3749	T14747	T14725	meta	Arber,note
R375	T1400	T1398	pobj	neurons,of
R3750	T14748	T14747	nmod	et,Arber
R3751	T14654	T14652	compound	KO,mice
R3752	T14749	T14747	nmod	al.,Arber
R3753	T14750	T14747	nummod	2000,Arber
R3754	T14751	T14747	punct	),Arber
R3755	T14655	T14609	punct	.,report
R3756	T14752	T14707	punct	.,is
R3757	T14754	T14755	nsubj	Patel,present
R3758	T14657	T14658	nsubj	It,is
R3759	T14756	T14757	advmod	et,al.
R376	T1401	T1402	punct	(,Oakley
R3760	T14757	T14754	advmod	al.,Patel
R3761	T14758	T14754	punct	(,Patel
R3762	T14759	T14754	npadvmod	2003,Patel
R3763	T14659	T14660	advmod	highly,possible
R3764	T14760	T14754	punct	),Patel
R3765	T14761	T14755	advmod	also,present
R3766	T14762	T14755	dobj	observations,present
R3767	T14660	T14658	acomp	possible,is
R3768	T14763	T14762	prep	from,observations
R3769	T14764	T14765	compound	islet2DTA,mice
R377	T1402	T1372	meta	Oakley,lead
R3770	T14765	T14763	pobj	mice,from
R3771	T14661	T14662	mark	that,express
R3772	T14766	T14765	punct	", ",mice
R3773	T14767	T14768	dep	which,lack
R3774	T14768	T14765	relcl	lack,mice
R3775	T14662	T14658	advcl	express,is
R3776	T14769	T14770	det	a,portion
R3777	T14770	T14768	dobj	portion,lack
R3778	T14771	T14770	amod	significant,portion
R3779	T14772	T14770	prep	of,portion
R378	T1403	T1402	nmod	et,Oakley
R3780	T14773	T14774	det	the,neurons
R3781	T14774	T14772	pobj	neurons,of
R3782	T14663	T14664	det	a,number
R3783	T14775	T14774	compound	motor,neurons
R3784	T14776	T14774	prep	in,neurons
R3785	T14777	T14778	det	the,cord
R3786	T14664	T14662	nsubj	number,express
R3787	T14778	T14776	pobj	cord,in
R3788	T14779	T14778	amod	ventral,cord
R3789	T14780	T14755	punct	.,present
R379	T1404	T1402	nmod	al.,Oakley
R3790	T14665	T14664	amod	small,number
R3791	T14782	T14783	prep	In,shows
R3792	T14666	T14665	cc	but,small
R3793	T14784	T14785	det	these,mice
R3794	T14785	T14782	pobj	mice,In
R3795	T14667	T14665	conj	considerable,small
R3796	T14786	T14787	compound	PV,immunostaining
R3797	T14787	T14783	nsubj	immunostaining,shows
R3798	T14788	T14783	dobj	axons,shows
R3799	T14668	T14664	prep	of,number
R38	T467	T465	pobj	signaling,of
R380	T1405	T1402	nummod	1995,Oakley
R3800	T14789	T14788	prep	in,axons
R3801	T14790	T14791	det	the,horns
R3802	T14791	T14789	pobj	horns,in
R3803	T14669	T14670	compound	DRG,cells
R3804	T14792	T14791	amod	ventral,horns
R3805	T14793	T14783	punct	.,shows
R3806	T14670	T14668	pobj	cells,of
R3807	T14795	T14796	nsubj	Patel,argue
R3808	T14671	T14672	det	the,factor
R3809	T14672	T14662	dobj	factor,express
R381	T1406	T1402	punct	", ",Oakley
R3810	T14797	T14798	advmod	et,al.
R3811	T14798	T14795	advmod	al.,Patel
R3812	T14673	T14672	compound	transcription,factor
R3813	T14799	T14800	mark	that,be
R3814	T14800	T14796	ccomp	be,argue
R3815	T14674	T14672	appos	Er81,factor
R3816	T14801	T14802	mark	since,are
R3817	T14802	T14800	advcl	are,be
R3818	T14803	T14804	compound	motor,neurons
R3819	T14675	T14662	cc	and,express
R382	T1407	T1402	nummod	1997,Oakley
R3820	T14804	T14802	nsubj	neurons,are
R3821	T14805	T14802	acomp	absent,are
R3822	T14806	T14802	prep	in,are
R3823	T14676	T14677	mark	that,grow
R3824	T14807	T14808	det	these,mice
R3825	T14808	T14806	pobj	mice,in
R3826	T14677	T14662	conj	grow,express
R3827	T14809	T14800	punct	", ",be
R3828	T14810	T14800	nsubj	NT,be
R3829	T14811	T14810	punct	-,NT
R383	T1408	T1402	punct	),Oakley
R3830	T14812	T14810	nummod	3,NT
R3831	T14813	T14810	acl	secreted,NT
R3832	T14814	T14813	prep	by,secreted
R3833	T14678	T14679	poss	their,axons
R3834	T14815	T14814	pobj	them,by
R3835	T14816	T14800	aux	could,be
R3836	T14817	T14800	neg	not,be
R3837	T14679	T14677	nsubj	axons,grow
R3838	T14818	T14819	det	a,signal
R3839	T14819	T14800	attr	signal,be
R384	T1409	T1372	punct	.,lead
R3840	T14820	T14821	mark	for,enter
R3841	T14680	T14677	prep	beyond,grow
R3842	T14821	T14819	advcl	enter,signal
R3843	T14822	T14823	amod	proprioceptive,axons
R3844	T14823	T14821	nsubj	axons,enter
R3845	T14681	T14682	det	the,levels
R3846	T14824	T14821	aux	to,enter
R3847	T14825	T14826	det	the,columns
R3848	T14682	T14680	pobj	levels,beyond
R3849	T14826	T14821	dobj	columns,enter
R385	T1412	T1411	nsubj	NT,Is
R3850	T14827	T14826	amod	lateral,columns
R3851	T14828	T14826	compound	motor,columns
R3852	T14683	T14682	amod	intermediate,levels
R3853	T14829	T14796	punct	.,argue
R3854	T14684	T14682	prep	of,levels
R3855	T14831	T14832	advmod	However,is
R3856	T14833	T14832	punct	", ",is
R3857	T14685	T14686	det	the,cord
R3858	T14834	T14832	expl	there,is
R3859	T14835	T14836	det	no,evidence
R386	T1413	T1412	punct	-,NT
R3860	T14836	T14832	attr	evidence,is
R3861	T14686	T14684	pobj	cord,of
R3862	T14837	T14836	acl	showing,evidence
R3863	T14838	T14839	mark	that,is
R3864	T14687	T14686	amod	spinal,cord
R3865	T14839	T14837	ccomp	is,showing
R3866	T14840	T14841	nmod	NT,mRNA
R3867	T14841	T14839	nsubj	mRNA,is
R3868	T14688	T14677	prep	in,grow
R3869	T14689	T14690	nmod	Bax,KO
R387	T1414	T1412	nummod	3,NT
R3870	T14690	T14696	compound	KO,mice
R3871	T14842	T14840	punct	-,NT
R3872	T14843	T14840	nummod	3,NT
R3873	T14844	T14841	cc	or,mRNA
R3874	T14691	T14689	punct	/,Bax
R3875	T14845	T14841	conj	protein,mRNA
R3876	T14846	T14845	acl	expressed,protein
R3877	T14692	T14689	appos	NT,Bax
R3878	T14847	T14846	prep	in,expressed
R3879	T14848	T14849	det	the,cord
R388	T1415	T1416	advmod	only,factor
R3880	T14849	T14847	pobj	cord,in
R3881	T14693	T14692	punct	-,NT
R3882	T14850	T14849	amod	ventral,cord
R3883	T14851	T14849	amod	spinal,cord
R3884	T14852	T14839	advmod	exclusively,is
R3885	T14853	T14839	prep	from,is
R3886	T14854	T14855	compound	motor,neurons
R3887	T14694	T14692	nummod	3,NT
R3888	T14855	T14853	pobj	neurons,from
R3889	T14856	T14832	punct	", ",is
R389	T1416	T1411	attr	factor,Is
R3890	T14857	T14832	cc	and,is
R3891	T14695	T14690	amod	double,KO
R3892	T14858	T14859	expl	there,are
R3893	T14859	T14832	conj	are,is
R3894	T14696	T14688	pobj	mice,in
R3895	T14860	T14861	det	no,data
R3896	T14861	T14859	attr	data,are
R3897	T14862	T14861	amod	available,data
R3898	T14697	T14658	punct	.,is
R3899	T14863	T14861	acl	indicating,data
R39	T468	T466	punct	-,NT
R390	T1417	T1416	det	a,factor
R3900	T14864	T14865	mark	that,abolished
R3901	T14699	T14700	mark	While,is
R3902	T14865	T14863	ccomp	abolished,indicating
R3903	T14700	T14707	advcl	is,is
R3904	T14866	T14865	prep	in,abolished
R3905	T14867	T14868	compound	islet2DTA,mice
R3906	T14868	T14866	pobj	mice,in
R3907	T14701	T14702	det	the,phenotype
R3908	T14869	T14865	punct	", ",abolished
R3909	T14870	T14871	nmod	NT,expression
R391	T1418	T1416	amod	chemotrophic,factor
R3910	T14871	T14865	nsubjpass	expression,abolished
R3911	T14702	T14700	nsubj	phenotype,is
R3912	T14872	T14870	punct	-,NT
R3913	T14873	T14870	nummod	3,NT
R3914	T14703	T14702	prep	of,phenotype
R3915	T14874	T14871	prep	in,expression
R3916	T14875	T14876	det	the,cord
R3917	T14876	T14874	pobj	cord,in
R3918	T14704	T14705	compound	Er81,KO
R3919	T14877	T14876	amod	ventral,cord
R392	T1419	T1416	compound	survival,factor
R3920	T14878	T14876	amod	spinal,cord
R3921	T14879	T14865	auxpass	is,abolished
R3922	T14705	T14706	compound	KO,mice
R3923	T14880	T14881	punct	(,Yang
R3924	T14881	T14832	meta	Yang,is
R3925	T14706	T14703	pobj	mice,of
R3926	T14708	T14709	advmod	quite,dramatic
R3927	T14882	T14881	nmod	et,Yang
R3928	T14883	T14881	nmod	al.,Yang
R3929	T14884	T14881	nummod	2001,Yang
R393	T1420	T1416	prep	for,factor
R3930	T14709	T14700	attr	dramatic,is
R3931	T14885	T14881	punct	;,Yang
R3932	T14886	T14881	nmod	Pun,Yang
R3933	T14887	T14881	nmod	et,Yang
R3934	T14888	T14881	nmod	al.,Yang
R3935	T14889	T14881	nummod	2002,Yang
R3936	T14710	T14700	punct	", ",is
R3937	T14890	T14881	punct	),Yang
R3938	T14891	T14832	punct	.,is
R3939	T14711	T14700	cc	and,is
R394	T1421	T1422	nmod	muscle,afferents
R3940	T14893	T14894	nsubj	Studies,reported
R3941	T14895	T14893	prep	in,Studies
R3942	T14712	T14713	amod	most,axons
R3943	T14896	T14897	amod	embryonic,mice
R3944	T14897	T14895	pobj	mice,in
R3945	T14713	T14715	nsubj	axons,stop
R3946	T14898	T14899	nmod	NT,mRNA
R3947	T14899	T14894	dobj	mRNA,reported
R3948	T14900	T14898	punct	-,NT
R3949	T14714	T14713	amod	proprioceptive,axons
R395	T1422	T1420	pobj	afferents,for
R3950	T14901	T14898	nummod	3,NT
R3951	T14902	T14894	prep	in,reported
R3952	T14715	T14700	conj	stop,is
R3953	T14903	T14904	det	the,horns
R3954	T14904	T14902	pobj	horns,in
R3955	T14905	T14904	amod	ventral,horns
R3956	T14716	T14715	prep	within,stop
R3957	T14906	T14904	prep	of,horns
R3958	T14907	T14908	det	the,cord
R3959	T14908	T14906	pobj	cord,of
R396	T1423	T1422	amod	sensory,afferents
R3960	T14717	T14718	det	the,cord
R3961	T14909	T14908	amod	spinal,cord
R3962	T14910	T14894	punct	", ",reported
R3963	T14911	T14894	cc	but,reported
R3964	T14718	T14716	pobj	cord,within
R3965	T14912	T14913	nsubj	it,is
R3966	T14913	T14894	conj	is,reported
R3967	T14719	T14718	amod	intermediate,cord
R3968	T14914	T14913	neg	not,is
R3969	T14915	T14913	acomp	definitive,is
R397	T1424	T1411	punct	", ",Is
R3970	T14916	T14917	mark	that,expressed
R3971	T14720	T14718	amod	spinal,cord
R3972	T14917	T14913	ccomp	expressed,is
R3973	T14918	T14919	preconj	both,mRNA
R3974	T14919	T14917	nsubjpass	mRNA,expressed
R3975	T14721	T14707	punct	", ",is
R3976	T14920	T14919	cc	and,mRNA
R3977	T14921	T14919	conj	protein,mRNA
R3978	T14722	T14707	nsubj	it,is
R3979	T14922	T14917	auxpass	are,expressed
R398	T1425	T1411	cc	or,Is
R3980	T14923	T14917	advmod	solely,expressed
R3981	T14924	T14917	agent	by,expressed
R3982	T14723	T14707	acomp	important,is
R3983	T14925	T14926	compound	motor,neurons
R3984	T14926	T14924	pobj	neurons,by
R3985	T14927	T14913	punct	.,is
R3986	T14929	T14930	prep	In,express
R3987	T14931	T14932	det	the,cord
R3988	T14724	T14725	aux	to,note
R3989	T14932	T14929	pobj	cord,In
R399	T1426	T1427	aux	does,have
R3990	T14933	T14932	amod	adult,cord
R3991	T14934	T14932	amod	spinal,cord
R3992	T14725	T14707	xcomp	note,is
R3993	T14935	T14930	punct	", ",express
R3994	T14936	T14937	mark	while,express
R3995	T14937	T14930	advcl	express,express
R3996	T14726	T14727	mark	that,find
R3997	T14938	T14939	compound	motor,neurons
R3998	T14939	T14937	nsubj	neurons,express
R3999	T14940	T14941	amod	high,levels
R4	T431	T424	punct	),required
R40	T469	T466	nummod	3,NT
R400	T1427	T1411	conj	have,Is
R4000	T14727	T14725	ccomp	find,note
R4001	T14941	T14937	dobj	levels,express
R4002	T14942	T14941	prep	of,levels
R4003	T14728	T14729	det	a,axons
R4004	T14943	T14942	pobj	NT,of
R4005	T14944	T14943	punct	-,NT
R4006	T14945	T14943	nummod	3,NT
R4007	T14729	T14727	nsubj	axons,find
R4008	T14946	T14930	punct	", ",express
R4009	T14947	T14948	amod	other,cells
R401	T1428	T1427	nsubj	it,have
R4010	T14730	T14729	amod	few,axons
R4011	T14731	T14727	advmod	still,find
R4012	T14732	T14733	poss	their,way
R4013	T14948	T14930	nsubj	cells,express
R4014	T14949	T14948	punct	", ",cells
R4015	T14950	T14948	prep	including,cells
R4016	T14733	T14727	dobj	way,find
R4017	T14951	T14950	pobj	glia,including
R4018	T14952	T14930	punct	", ",express
R4019	T14734	T14727	prep	to,find
R402	T1429	T1430	amod	additional,roles
R4020	T14953	T14930	advmod	also,express
R4021	T14954	T14930	dobj	it,express
R4022	T14955	T14956	punct	(,Zhou
R4023	T14735	T14736	det	the,cord
R4024	T14956	T14930	meta	Zhou,express
R4025	T14957	T14956	cc	and,Zhou
R4026	T15054	T15050	pobj	null,in
R4027	T14958	T14956	conj	Rush,Zhou
R4028	T14959	T14958	nummod	1994,Rush
R4029	T14960	T14958	punct	;,Rush
R403	T1430	T1427	dobj	roles,have
R4030	T14961	T14958	conj	Dreyfus,Rush
R4031	T14962	T14961	nmod	et,Dreyfus
R4032	T15055	T15050	cc	and,in
R4033	T14963	T14961	nmod	al.,Dreyfus
R4034	T15056	T15050	conj	in,in
R4035	T15057	T15058	npadvmod	p75,null
R4036	T14964	T14961	nummod	1999,Dreyfus
R4037	T14965	T14961	punct	;,Dreyfus
R4038	T14966	T14961	conj	Buck,Dreyfus
R4039	T14967	T14966	nmod	et,Buck
R404	T1431	T1430	prep	in,roles
R4040	T14968	T14966	nmod	al.,Buck
R4041	T14969	T14966	nummod	2000,Buck
R4042	T14970	T14966	punct	),Buck
R4043	T15058	T15056	pobj	null,in
R4044	T14971	T14930	punct	.,express
R4045	T14973	T14974	poss	Our,results
R4046	T15059	T15060	compound	DRG,explants
R4047	T14974	T14976	nsubj	results,argue
R4048	T14975	T14974	amod	present,results
R4049	T15060	T15056	pobj	explants,in
R405	T1432	T1433	det	the,development
R4050	T14977	T14974	punct	", ",results
R4051	T14978	T14974	cc	along,results
R4052	T15061	T15050	punct	", ",in
R4053	T14979	T14978	dep	with,along
R4054	T14980	T14974	conj	those,results
R4055	T15062	T15050	cc	and,in
R4056	T14981	T14980	prep	from,those
R4057	T14982	T14983	amod	transgenic,mice
R4058	T14983	T14981	pobj	mice,from
R4059	T15063	T15050	conj	in,in
R406	T1433	T1431	pobj	development,in
R4060	T14984	T14983	prep	with,mice
R4061	T14985	T14986	nmod	NT,over-expression
R4062	T14986	T14984	pobj	over-expression,with
R4063	T15064	T15065	det	the,absence
R4064	T14987	T14985	punct	-,NT
R4065	T14988	T14985	nummod	3,NT
R4066	T14989	T14986	prep	in,over-expression
R4067	T15065	T15063	pobj	absence,in
R4068	T14990	T14991	amod	ectopic,regions
R4069	T14991	T14989	pobj	regions,in
R407	T1434	T1433	prep	of,development
R4070	T15066	T15065	prep	of,absence
R4071	T14992	T14991	prep	of,regions
R4072	T14993	T14994	det	the,cord
R4073	T14994	T14992	pobj	cord,of
R4074	T15067	T15068	det	any,neurotrophins
R4075	T14995	T14994	amod	spinal,cord
R4076	T14996	T14997	punct	(,Ringstedt
R4077	T14997	T14980	meta	Ringstedt,those
R4078	T15068	T15066	pobj	neurotrophins,of
R4079	T14998	T14997	nmod	et,Ringstedt
R408	T1435	T1436	det	the,proprioceptors
R4080	T14999	T14997	nmod	al.,Ringstedt
R4081	T15069	T15068	amod	other,neurotrophins
R4082	T15000	T14997	nummod	1997,Ringstedt
R4083	T15001	T14997	punct	),Ringstedt
R4084	T15002	T14976	punct	", ",argue
R4085	T15070	T15068	cc	or,neurotrophins
R4086	T15003	T14976	prep	for,argue
R4087	T15004	T15005	det	a,role
R4088	T15005	T15003	pobj	role,for
R4089	T15071	T15072	npadvmod	target,derived
R409	T1436	T1434	pobj	proprioceptors,of
R4090	T15006	T15005	prep	of,role
R4091	T15007	T15006	pobj	NT,of
R4092	T15008	T15007	punct	-,NT
R4093	T15009	T15007	nummod	3,NT
R4094	T15010	T15005	prep	in,role
R4095	T15011	T15012	compound	chemoattractant,guidance
R4096	T15072	T15074	amod	derived,molecules
R4097	T15012	T15010	pobj	guidance,in
R4098	T15013	T15012	compound	axon,guidance
R4099	T15014	T15012	prep	of,guidance
R41	T470	T440	punct	.,rescues
R410	T1437	T1433	cc	and,development
R4100	T15073	T15072	punct	-,derived
R4101	T15015	T15016	amod	proprioceptive,axons
R4102	T15016	T15014	pobj	axons,of
R4103	T15017	T15012	prep	in,guidance
R4104	T15074	T15068	conj	molecules,neurotrophins
R4105	T15018	T15019	det	the,cord
R4106	T15019	T15017	pobj	cord,in
R4107	T15075	T15076	compound	axon,guidance
R4108	T15020	T15019	amod	spinal,cord
R4109	T15021	T14976	punct	.,argue
R411	T1438	T1439	det	the,establishment
R4110	T15076	T15074	compound	guidance,molecules
R4111	T15023	T15024	advmod	Finally,see
R4112	T15025	T15024	punct	", ",see
R4113	T15077	T15048	punct	.,seen
R4114	T15026	T15024	prep	in,see
R4115	T15027	T15028	compound	culture,assays
R4116	T15028	T15026	pobj	assays,in
R4117	T15079	T15080	advmod	Furthermore,appear
R4118	T15029	T15024	punct	", ",see
R4119	T15030	T15024	nsubj	we,see
R412	T1439	T1433	conj	establishment,development
R4120	T15031	T15032	det	a,chemoattraction
R4121	T15032	T15024	dobj	chemoattraction,see
R4122	T15081	T15080	punct	", ",appear
R4123	T15033	T15032	amod	strong,chemoattraction
R4124	T15034	T15032	prep	of,chemoattraction
R4125	T15035	T15036	compound	DRG,neurons
R4126	T15036	T15034	pobj	neurons,of
R4127	T15082	T15083	advmod	in,vitro
R4128	T15037	T15032	prep	to,chemoattraction
R4129	T15038	T15039	amod	localized,sources
R413	T1440	T1439	prep	of,establishment
R4130	T15039	T15037	pobj	sources,to
R4131	T15083	T15080	advmod	vitro,appear
R4132	T15040	T15039	prep	of,sources
R4133	T15041	T15040	pobj	NT,of
R4134	T15084	T15080	punct	", ",appear
R4135	T15042	T15041	punct	-,NT
R4136	T15043	T15041	nummod	3,NT
R4137	T15044	T15024	punct	.,see
R4138	T15085	T15086	amod	sensory,axon
R4139	T15046	T15047	det	This,response
R414	T1441	T1442	det	the,arc
R4140	T15047	T15048	nsubjpass	response,seen
R4141	T15086	T15087	compound	axon,response
R4142	T15049	T15048	auxpass	is,seen
R4143	T15050	T15048	prep	in,seen
R4144	T15087	T15080	nsubj	response,appear
R4145	T15051	T15052	nmod	WT,Bax
R4146	T15052	T15054	npadvmod	Bax,null
R4147	T15053	T15052	punct	", ",Bax
R4148	T15088	T15087	prep	to,response
R4149	T15089	T15088	pobj	NT,to
R415	T1442	T1440	pobj	arc,of
R4150	T15090	T15089	punct	-,NT
R4151	T15160	T15159	amod	primary,axons
R4152	T15091	T15089	nummod	3,NT
R4153	T15161	T15159	amod	sensory,axons
R4154	T15162	T15147	aux	have,indicated
R4155	T15092	T15080	aux	does,appear
R4156	T15163	T15164	mark	that,attract
R4157	T15164	T15147	ccomp	attract,indicated
R4158	T15093	T15080	neg	not,appear
R4159	T15165	T15166	det	this,neurotrophin
R416	T1443	T1442	amod	monosynaptic,arc
R4160	T15166	T15164	nsubj	neurotrophin,attract
R4161	T15167	T15164	aux	can,attract
R4162	T15168	T15164	cc	and,attract
R4163	T15094	T15095	aux	to,be
R4164	T15169	T15164	conj	induce,attract
R4165	T15170	T15171	amod	axonal,branching
R4166	T15095	T15080	xcomp	be,appear
R4167	T15171	T15169	dobj	branching,induce
R4168	T15172	T15173	punct	(,Ulupınar
R4169	T15173	T15147	meta	Ulupınar,indicated
R417	T1444	T1442	compound	reflex,arc
R4170	T15096	T15097	npadvmod	dose,dependent
R4171	T15174	T15173	nmod	et,Ulupınar
R4172	T15175	T15173	nmod	al.,Ulupınar
R4173	T15176	T15173	nummod	2000,Ulupınar
R4174	T15097	T15095	acomp	dependent,be
R4175	T15177	T15173	punct	;,Ulupınar
R4176	T15178	T15173	conj	Özdinler,Ulupınar
R4177	T15179	T15178	cc	and,Özdinler
R4178	T15098	T15097	punct	-,dependent
R4179	T15180	T15178	conj	Erzurumlu,Özdinler
R418	T1445	T1427	punct	?,have
R4180	T15181	T15180	nummod	2001,Erzurumlu
R4181	T15182	T15180	punct	", ",Erzurumlu
R4182	T15099	T15100	punct	(,Ringstedt
R4183	T15183	T15180	conj	Özdinler,Erzurumlu
R4184	T15184	T15183	nmod	et,Özdinler
R4185	T15185	T15183	nmod	al.,Özdinler
R4186	T15100	T15080	meta	Ringstedt,appear
R4187	T15186	T15183	nummod	2004,Özdinler
R4188	T15187	T15183	punct	),Özdinler
R4189	T15188	T15147	punct	.,indicated
R419	T1447	T1448	advmod	Here,provide
R4190	T15101	T15100	nmod	et,Ringstedt
R4191	T15190	T15191	prep	Along,implicated
R4192	T15102	T15100	nmod	al.,Ringstedt
R4193	T15192	T15193	det	the,pathway
R4194	T15193	T15190	pobj	pathway,Along
R4195	T15194	T15193	amod	monosynaptic,pathway
R4196	T15195	T15196	compound	stretch,reflex
R4197	T15196	T15193	compound	reflex,pathway
R4198	T15197	T15191	punct	", ",implicated
R4199	T15103	T15100	nummod	1997,Ringstedt
R42	T472	T473	npadvmod	TrkC,positive
R420	T1449	T1448	nsubj	we,provide
R4200	T15198	T15199	advmod	only,Wnt
R4201	T15199	T15191	nsubjpass	Wnt,implicated
R4202	T15200	T15199	punct	-,Wnt
R4203	T15104	T15100	punct	;,Ringstedt
R4204	T15201	T15199	nummod	3,Wnt
R4205	T15202	T15191	aux	has,implicated
R4206	T15203	T15191	auxpass	been,implicated
R4207	T15105	T15100	nmod	Tucker,Ringstedt
R4208	T15204	T15191	prep	as,implicated
R4209	T15205	T15206	det	an,factor
R421	T1450	T1448	dobj	evidence,provide
R4210	T15206	T15204	pobj	factor,as
R4211	T15106	T15100	nmod	et,Ringstedt
R4212	T15207	T15208	compound	axon,arborization
R4213	T15208	T15206	compound	arborization,factor
R4214	T15209	T15206	prep	in,factor
R4215	T15107	T15100	nmod	al.,Ringstedt
R4216	T15210	T15211	det	the,cord
R4217	T15211	T15209	pobj	cord,in
R4218	T15108	T15100	nummod	2001,Ringstedt
R4219	T15212	T15211	amod	spinal,cord
R422	T1451	T1452	mark	that,acts
R4220	T15213	T15214	punct	(,Krylova
R4221	T15214	T15191	meta	Krylova,implicated
R4222	T15109	T15100	punct	),Ringstedt
R4223	T15215	T15214	nmod	et,Krylova
R4224	T15216	T15214	nmod	al.,Krylova
R4225	T15217	T15214	nummod	2002,Krylova
R4226	T15110	T15080	punct	.,appear
R4227	T15218	T15214	punct	),Krylova
R4228	T15219	T15191	punct	.,implicated
R4229	T15112	T15113	nsubj	NT,is
R423	T1452	T1450	acl	acts,evidence
R4230	T15221	T15222	det	Another,molecule
R4231	T15114	T15112	punct	-,NT
R4232	T15222	T15223	nsubj	molecule,is
R4233	T15115	T15112	nummod	3,NT
R4234	T15224	T15222	punct	", ",molecule
R4235	T15225	T15222	appos	Slit2,molecule
R4236	T15226	T15222	punct	", ",molecule
R4237	T15116	T15113	acomp	capable,is
R4238	T15227	T15222	acl	expressed,molecule
R4239	T15228	T15227	prep	in,expressed
R424	T1453	T1452	nsubj	NT,acts
R4240	T15229	T15230	det	the,midline
R4241	T15117	T15116	prep	of,capable
R4242	T15230	T15228	pobj	midline,in
R4243	T15231	T15228	cc	and,in
R4244	T15118	T15117	pcomp	attracting,of
R4245	T15232	T15228	conj	by,in
R4246	T15233	T15234	compound	motor,neurons
R4247	T15234	T15232	pobj	neurons,by
R4248	T15235	T15236	punct	(,Wang
R4249	T15236	T15227	meta	Wang,expressed
R425	T1454	T1453	punct	-,NT
R4250	T15237	T15236	nmod	et,Wang
R4251	T15238	T15236	nmod	al.,Wang
R4252	T15119	T15118	dobj	axons,attracting
R4253	T15239	T15236	nummod	1999,Wang
R4254	T15240	T15236	punct	),Wang
R4255	T15241	T15223	acomp	capable,is
R4256	T15120	T15118	prep	along,attracting
R4257	T15242	T15241	prep	of,capable
R4258	T15243	T15242	pcomp	inducing,of
R4259	T15244	T15245	amod	axonal,branching
R426	T1455	T1453	nummod	3,NT
R4260	T15245	T15243	dobj	branching,inducing
R4261	T15121	T15120	pobj	distances,along
R4262	T15246	T15247	punct	(,Nguyen
R4263	T15247	T15223	meta	Nguyen,is
R4264	T15248	T15247	nmod	Ba,Nguyen
R4265	T15122	T15121	prep	of,distances
R4266	T15249	T15247	punct	-,Nguyen
R4267	T15250	T15247	nmod	Charvet,Nguyen
R4268	T15123	T15124	quantmod	up,1
R4269	T15251	T15247	nmod	et,Nguyen
R427	T1456	T1452	prep	as,acts
R4270	T15252	T15247	nmod	al.,Nguyen
R4271	T15253	T15247	nummod	2001,Nguyen
R4272	T15124	T15126	nummod	1,mm
R4273	T15254	T15247	punct	;,Nguyen
R4274	T15255	T15247	conj	Özdinler,Nguyen
R4275	T15256	T15255	cc	and,Özdinler
R4276	T15125	T15124	quantmod	to,1
R4277	T15257	T15255	conj	Erzurumlu,Özdinler
R4278	T15258	T15257	nummod	2002,Erzurumlu
R4279	T15259	T15257	punct	),Erzurumlu
R428	T1457	T1458	det	a,chemoattractant
R4280	T15126	T15122	pobj	mm,of
R4281	T15260	T15223	punct	.,is
R4282	T15127	T15118	prep	in,attracting
R4283	T15262	T15263	compound	DRG,neurons
R4284	T15263	T15264	nsubj	neurons,express
R4285	T15265	T15266	compound	Robo,receptors
R4286	T15128	T15129	compound	collagen,matrix
R4287	T15129	T15127	pobj	matrix,in
R4288	T15130	T15129	compound	gel,matrix
R4289	T15131	T15113	punct	", ",is
R429	T1458	T1456	pobj	chemoattractant,as
R4290	T15266	T15264	dobj	receptors,express
R4291	T15267	T15266	punct	", ",receptors
R4292	T15268	T15269	dep	which,bind
R4293	T15269	T15266	relcl	bind,receptors
R4294	T15132	T15113	advcl	covering,is
R4295	T15133	T15134	det	the,range
R4296	T15134	T15132	dobj	range,covering
R4297	T15135	T15134	amod	physiological,range
R4298	T15270	T15269	prep	to,bind
R4299	T15271	T15270	pobj	Slits,to
R43	T473	T475	amod	positive,axons
R430	T1459	T1458	prep	for,chemoattractant
R4300	T15272	T15264	punct	", ",express
R4301	T15273	T15264	cc	and,express
R4302	T15274	T15275	amod	proprioceptive,axons
R4303	T15136	T15137	nsubj	it,needs
R4304	T15275	T15276	nsubj	axons,are
R4305	T15276	T15264	conj	are,express
R4306	T15277	T15276	advmod	therefore,are
R4307	T15137	T15134	advcl	needs,range
R4308	T15278	T15276	acomp	capable,are
R4309	T15279	T15278	prep	of,capable
R431	T1460	T1461	amod	sensory,axons
R4310	T15280	T15279	pcomp	responding,of
R4311	T15138	T15139	aux	to,attract
R4312	T15281	T15280	prep	to,responding
R4313	T15282	T15283	compound	Slit,signals
R4314	T15283	T15281	pobj	signals,to
R4315	T15284	T15285	punct	(,Wang
R4316	T15139	T15137	advcl	attract,needs
R4317	T15285	T15276	meta	Wang,are
R4318	T15286	T15285	nmod	et,Wang
R4319	T15140	T15139	dobj	axons,attract
R432	T1461	T1459	pobj	axons,for
R4320	T15287	T15285	nmod	al.,Wang
R4321	T15288	T15285	nummod	1999,Wang
R4322	T15289	T15285	punct	),Wang
R4323	T15290	T15276	punct	.,are
R4324	T15141	T15139	prep	during,attract
R4325	T15292	T15293	nsubj	Slit2,cause
R4326	T15142	T15141	pobj	development,during
R4327	T15294	T15293	aux	does,cause
R4328	T15295	T15293	neg	not,cause
R4329	T15296	T15293	dobj	repulsion,cause
R433	T1462	T1452	prep	during,acts
R4330	T15143	T15113	punct	.,is
R4331	T15297	T15296	prep	of,repulsion
R4332	T15298	T15299	npadvmod	NT,responsive
R4333	T15299	T15303	amod	responsive,axons
R4334	T15145	T15146	amod	Previous,studies
R4335	T15300	T15298	punct	-,NT
R4336	T15301	T15298	nummod	3,NT
R4337	T15302	T15299	punct	-,responsive
R4338	T15303	T15297	pobj	axons,of
R4339	T15146	T15147	nsubj	studies,indicated
R434	T1463	T1464	det	the,phase
R4340	T15304	T15303	compound	DRG,axons
R4341	T15305	T15306	advmod	in,vitro
R4342	T15148	T15146	prep	with,studies
R4343	T15306	T15293	advmod	vitro,cause
R4344	T15307	T15308	punct	(,Nguyen
R4345	T15149	T15150	amod	exogenous,applications
R4346	T15308	T15293	meta	Nguyen,cause
R4347	T15150	T15148	pobj	applications,with
R4348	T15309	T15308	nmod	Ba,Nguyen
R4349	T15310	T15308	punct	-,Nguyen
R435	T1464	T1462	pobj	phase,during
R4350	T15311	T15308	nmod	Charvet,Nguyen
R4351	T15312	T15308	nmod	et,Nguyen
R4352	T15313	T15308	nmod	al.,Nguyen
R4353	T15314	T15308	nummod	2001,Nguyen
R4354	T15151	T15149	cc	or,exogenous
R4355	T15315	T15308	punct	),Nguyen
R4356	T15316	T15293	punct	", ",cause
R4357	T15152	T15149	conj	local,exogenous
R4358	T15317	T15293	cc	but,cause
R4359	T15318	T15293	conj	causes,cause
R436	T1465	T1464	amod	final,phase
R4360	T15153	T15150	prep	of,applications
R4361	T15319	T15320	amod	ectopic,branching
R4362	T15320	T15318	dobj	branching,causes
R4363	T15321	T15320	cc	and,branching
R4364	T15154	T15153	pobj	NT,of
R4365	T15322	T15320	conj	arborization,branching
R4366	T15323	T15320	prep	of,branching
R4367	T15324	T15325	amod	trigeminal,axons
R4368	T15155	T15154	punct	-,NT
R4369	T15325	T15323	pobj	axons,of
R437	T1466	T1464	prep	of,phase
R4370	T15326	T15318	prep	in,causes
R4371	T15327	T15328	det	the,brainstem
R4372	T15156	T15154	nummod	3,NT
R4373	T15328	T15326	pobj	brainstem,in
R4374	T15329	T15330	punct	(,Özdinler
R4375	T15157	T15150	prep	to,applications
R4376	T15330	T15318	meta	Özdinler,causes
R4377	T15331	T15330	cc	and,Özdinler
R4378	T15332	T15330	conj	Erzurumlu,Özdinler
R4379	T15158	T15159	amod	developing,axons
R438	T1467	T1468	poss	their,pathfinding
R4380	T15333	T15332	nummod	2002,Erzurumlu
R4381	T15334	T15332	punct	),Erzurumlu
R4382	T15159	T15157	pobj	axons,to
R4383	T15335	T15293	punct	.,cause
R4384	T15337	T15338	advmod	Thus,involved
R4385	T15372	T15373	nmod	Bax,KO
R4386	T15339	T15338	punct	", ",involved
R4387	T15340	T15338	nsubjpass	Slit2,involved
R4388	T15341	T15338	aux	might,involved
R4389	T15373	T15378	compound	KO,mice
R439	T1468	T1466	pobj	pathfinding,of
R4390	T15342	T15338	advmod	also,involved
R4391	T15343	T15338	auxpass	be,involved
R4392	T15344	T15338	prep	in,involved
R4393	T15374	T15372	punct	/,Bax
R4394	T15345	T15346	amod	terminal,branching
R4395	T15346	T15344	pobj	branching,in
R4396	T15347	T15346	prep	of,branching
R4397	T15375	T15372	appos	NT,Bax
R4398	T15348	T15349	amod	propioceptive,axons
R4399	T15349	T15347	pobj	axons,of
R44	T474	T473	punct	-,positive
R440	T1469	T1470	npadvmod	target,directed
R4400	T15350	T15346	prep	in,branching
R4401	T15376	T15375	punct	-,NT
R4402	T15351	T15352	det	the,cord
R4403	T15352	T15350	pobj	cord,in
R4404	T15353	T15352	amod	ventral,cord
R4405	T15354	T15344	cc	and,in
R4406	T15355	T15344	conj	in,in
R4407	T15356	T15357	det	the,branching
R4408	T15377	T15375	nummod	3,NT
R4409	T15357	T15355	pobj	branching,in
R441	T1470	T1468	amod	directed,pathfinding
R4410	T15358	T15357	compound	midline,branching
R4411	T15359	T15357	acl	observed,branching
R4412	T15378	T15371	pobj	mice,in
R4413	T15360	T15359	prep	in,observed
R4414	T15361	T15362	poss	our,KOs
R4415	T15362	T15360	pobj	KOs,in
R4416	T15379	T15380	mark	that,be
R4417	T15363	T15362	amod	double,KOs
R4418	T15364	T15338	punct	.,involved
R4419	T15380	T15367	ccomp	be,suggests
R442	T1471	T1470	punct	-,directed
R4420	T15366	T15367	nsubj	Lack,suggests
R4421	T15381	T15382	compound	PV,expression
R4422	T15368	T15366	prep	of,Lack
R4423	T15369	T15370	compound	PV,expression
R4424	T15370	T15368	pobj	expression,of
R4425	T15382	T15380	nsubj	expression,be
R4426	T15371	T15366	prep	in,Lack
R4427	T15383	T15380	aux	might,be
R4428	T15384	T15380	acomp	responsible,be
R4429	T15478	T15476	pobj	expression,of
R443	T1472	T1448	punct	.,provide
R4430	T15385	T15384	prep	for,responsible
R4431	T15479	T15475	prep	in,lack
R4432	T15386	T15387	amod	proper,targeting
R4433	T15480	T15481	amod	proprioceptive,cells
R4434	T15387	T15385	pobj	targeting,for
R4435	T15481	T15479	pobj	cells,in
R4436	T15482	T15455	punct	.,suggest
R4437	T15388	T15387	compound	axon,targeting
R4438	T15389	T15387	cc	and,targeting
R4439	T15484	T15485	poss	Our,results
R444	T2324	T2325	npadvmod	TrkC,Positive
R4440	T15485	T15487	nsubj	results,suggest
R4441	T15486	T15485	amod	present,results
R4442	T15390	T15391	compound	muscle,spindle
R4443	T15488	T15489	mark	that,acts
R4444	T15391	T15392	compound	spindle,differentiation
R4445	T15489	T15487	ccomp	acts,suggest
R4446	T15490	T15489	nsubj	NT,acts
R4447	T15491	T15490	punct	-,NT
R4448	T15392	T15387	conj	differentiation,targeting
R4449	T15492	T15490	nummod	3,NT
R445	T2325	T2327	amod	Positive,Neurons
R4450	T15493	T15489	prep	as,acts
R4451	T15393	T15367	punct	.,suggests
R4452	T15494	T15495	det	a,cue
R4453	T15495	T15493	pobj	cue,as
R4454	T15496	T15497	amod	short,range
R4455	T15497	T15495	compound	range,cue
R4456	T15498	T15497	punct	-,range
R4457	T15499	T15500	compound	axon,guidance
R4458	T15500	T15495	compound	guidance,cue
R4459	T15501	T15489	prep	for,acts
R446	T2326	T2325	punct	-,Positive
R4460	T15395	T15396	advmod	Presently,rule
R4461	T15502	T15503	amod	proprioceptive,axons
R4462	T15503	T15501	pobj	axons,for
R4463	T15504	T15489	advmod	centrally,acts
R4464	T15505	T15504	cc	and,centrally
R4465	T15397	T15396	nsubj	we,rule
R4466	T15506	T15504	conj	peripherally,centrally
R4467	T15507	T15489	punct	", ",acts
R4468	T15508	T15509	mark	as,navigate
R4469	T15509	T15489	advcl	navigate,acts
R447	T2327	T2329	nsubjpass	Neurons,Rescued
R4470	T15398	T15396	aux	can,rule
R4471	T15510	T15509	nsubj	they,navigate
R4472	T15511	T15509	prep	to,navigate
R4473	T15512	T15513	poss	their,targets
R4474	T15399	T15396	neg	not,rule
R4475	T15513	T15511	pobj	targets,to
R4476	T15514	T15509	advcl	using,navigate
R4477	T15400	T15396	advmod	completely,rule
R4478	T15515	T15516	amod	other,cues
R4479	T15516	T15514	dobj	cues,using
R448	T2328	T2327	compound	DRG,Neurons
R4480	T15517	T15518	compound	axon,guidance
R4481	T15518	T15516	compound	guidance,cues
R4482	T15401	T15396	prt	out,rule
R4483	T15519	T15487	punct	.,suggest
R4484	T15402	T15403	det	this,possibility
R4485	T15521	T15522	prep	In,terminate
R4486	T15523	T15524	poss	its,absence
R4487	T15403	T15396	dobj	possibility,rule
R4488	T15524	T15521	pobj	absence,In
R4489	T15525	T15522	punct	", ",terminate
R449	T2330	T2329	auxpass	Are,Rescued
R4490	T15526	T15527	det	these,axons
R4491	T15404	T15396	punct	.,rule
R4492	T15527	T15522	nsubj	axons,terminate
R4493	T15528	T15522	prep	in,terminate
R4494	T15406	T15407	advmod	However,noted
R4495	T15529	T15530	amod	inappropriate,loci
R4496	T15530	T15528	pobj	loci,in
R4497	T15531	T15522	punct	.,terminate
R4498	T15408	T15407	punct	", ",noted
R4499	T15533	T15534	advmod	However,be
R45	T475	T479	nsubj	axons,follow
R450	T2331	T2329	prep	in,Rescued
R4500	T15535	T15534	punct	", ",be
R4501	T15536	T15534	nsubj	NT,be
R4502	T15409	T15410	det	no,defects
R4503	T15537	T15536	punct	-,NT
R4504	T15538	T15536	nummod	3,NT
R4505	T15410	T15407	nsubjpass	defects,noted
R4506	T15539	T15534	aux	may,be
R4507	T15540	T15534	neg	not,be
R4508	T15541	T15542	det	the,molecule
R4509	T15542	T15534	attr	molecule,be
R451	T2332	T2333	nmod	Bax,Knockout
R4510	T15543	T15542	amod	only,molecule
R4511	T15544	T15545	dep	that,plays
R4512	T15411	T15410	prep	in,defects
R4513	T15545	T15542	relcl	plays,molecule
R4514	T15546	T15547	det	a,role
R4515	T15547	T15545	dobj	role,plays
R4516	T15412	T15413	compound	axon,pathfinding
R4517	T15548	T15545	prep	in,plays
R4518	T15549	T15548	pobj	targeting,in
R4519	T15550	T15549	cc	and,targeting
R452	T2333	T2339	compound	Knockout,Mice
R4520	T15413	T15411	pobj	pathfinding,in
R4521	T15551	T15552	amod	terminal,branching
R4522	T15552	T15549	conj	branching,targeting
R4523	T15414	T15410	prep	along,defects
R4524	T15553	T15549	prep	of,targeting
R4525	T15554	T15555	amod	sensory,axons
R4526	T15555	T15553	pobj	axons,of
R4527	T15415	T15416	det	the,arc
R4528	T15556	T15549	prep	in,targeting
R4529	T15557	T15558	det	the,cord
R453	T2334	T2332	punct	/,Bax
R4530	T15558	T15556	pobj	cord,in
R4531	T15416	T15414	pobj	arc,along
R4532	T15559	T15558	amod	ventral,cord
R4533	T15560	T15558	amod	spinal,cord
R4534	T15561	T15534	punct	.,be
R4535	T15417	T15416	amod	monosynaptic,arc
R4536	T15563	T15564	nsubj	NT,acts
R4537	T15418	T15416	compound	reflex,arc
R4538	T15565	T15563	punct	-,NT
R4539	T15566	T15563	nummod	3,NT
R454	T2335	T2332	appos	NT,Bax
R4540	T15419	T15414	cc	or,along
R4541	T15567	T15568	advmod	most,likely
R4542	T15568	T15564	advmod	likely,acts
R4543	T15420	T15414	conj	in,along
R4544	T15569	T15564	advmod	cooperatively,acts
R4545	T15421	T15422	compound	muscle,spindle
R4546	T15570	T15564	prep	with,acts
R4547	T15571	T15572	amod	other,molecules
R4548	T15572	T15570	pobj	molecules,with
R4549	T15422	T15423	compound	spindle,differentiation
R455	T2336	T2335	punct	-,NT
R4550	T15573	T15574	compound	axon,guidance
R4551	T15574	T15572	compound	guidance,molecules
R4552	T15575	T15570	cc	or,with
R4553	T15423	T15420	pobj	differentiation,in
R4554	T15576	T15570	conj	by,with
R4555	T15577	T15576	pcomp	regulating,by
R4556	T15424	T15407	aux	have,noted
R4557	T15578	T15577	dobj	expression,regulating
R4558	T15579	T15578	prep	of,expression
R4559	T15580	T15581	advmod	yet,identified
R456	T2337	T2335	nummod	3,NT
R4560	T15581	T15579	pobj	identified,of
R4561	T15582	T15581	aux	to,identified
R4562	T15583	T15581	auxpass	be,identified
R4563	T15425	T15407	auxpass	been,noted
R4564	T15426	T15407	prep	in,noted
R4565	T15584	T15585	amod	proprioceptive,neuron
R4566	T15585	T15586	npadvmod	neuron,specific
R4567	T15586	T15581	amod	specific,identified
R4568	T15427	T15428	compound	PV,KO
R4569	T15587	T15586	punct	-,specific
R457	T2338	T2333	amod	Double,Knockout
R4570	T15588	T15589	compound	receptors,ligands
R4571	T15428	T15429	compound	KO,mice
R4572	T15589	T15581	appos	ligands,identified
R4573	T15590	T15589	punct	/,ligands
R4574	T15591	T15577	prep	for,regulating
R4575	T15429	T15426	pobj	mice,in
R4576	T15592	T15593	amod	numerous,cues
R4577	T15593	T15591	pobj	cues,for
R4578	T15594	T15595	compound	axon,guidance
R4579	T15430	T15429	punct	", ",mice
R458	T2339	T2331	pobj	Mice,in
R4580	T15595	T15593	compound	guidance,cues
R4581	T15596	T15564	punct	.,acts
R4582	T15431	T15432	dep	which,develop
R4583	T15432	T15429	relcl	develop,mice
R4584	T15433	T15432	advmod	normally,develop
R4585	T15434	T15432	cc	and,develop
R4586	T15435	T15432	conj	show,develop
R4587	T15436	T15437	det	no,changes
R4588	T15437	T15435	dobj	changes,show
R4589	T15438	T15437	amod	apparent,changes
R459	T2341	T2342	nsubj	Mice,allow
R4590	T15439	T15437	prep	in,changes
R4591	T15440	T15441	poss	their,behavior
R4592	T15441	T15439	pobj	behavior,in
R4593	T15442	T15441	cc	or,behavior
R4594	T15443	T15444	amod	physical,activity
R4595	T15444	T15441	conj	activity,behavior
R4596	T15445	T15446	punct	(,Schwaller
R4597	T15446	T15407	meta	Schwaller,noted
R4598	T15447	T15446	nmod	et,Schwaller
R4599	T15448	T15446	nmod	al.,Schwaller
R46	T476	T475	amod	peripheral,axons
R460	T2343	T2341	acl	lacking,Mice
R4600	T15449	T15446	nummod	1999,Schwaller
R4601	T15450	T15446	punct	),Schwaller
R4602	T15451	T15407	punct	.,noted
R4603	T15453	T15454	det	These,observations
R4604	T15454	T15455	nsubj	observations,suggest
R4605	T15456	T15457	mark	that,be
R4606	T15457	T15455	ccomp	be,suggest
R4607	T15458	T15459	amod	axonal,defects
R4608	T15459	T15457	nsubj	defects,be
R4609	T15460	T15459	amod	targeting,defects
R461	T2344	T2345	amod	proapoptotic,Bax
R4610	T15461	T15459	prep	in,defects
R4611	T15462	T15463	nmod	Bax,KO
R4612	T15463	T15469	compound	KO,mice
R4613	T15464	T15462	punct	/,Bax
R4614	T15465	T15462	appos	NT,Bax
R4615	T15466	T15465	punct	-,NT
R4616	T15467	T15465	nummod	3,NT
R4617	T15468	T15463	amod	double,KO
R4618	T15469	T15461	pobj	mice,in
R4619	T15470	T15457	aux	can,be
R462	T2345	T2343	dobj	Bax,lacking
R4620	T15471	T15457	neg	not,be
R4621	T15472	T15457	advmod	simply,be
R4622	T15473	T15457	prep	due,be
R4623	T15474	T15473	pcomp	to,due
R4624	T15475	T15473	pobj	lack,due
R4625	T15476	T15475	prep	of,lack
R4626	T15477	T15478	compound	PV,expression
R4627	T16204	T16203	prep	of,Generation
R4628	T16205	T16206	amod	double,KOs
R4629	T16206	T16204	pobj	KOs,of
R463	T2346	T2345	compound	protein,Bax
R4630	T16207	T16203	punct	.,Generation
R4631	T16209	T16210	nsubj	We,crossed
R4632	T16211	T16212	compound	Bax,KO
R4633	T16212	T16213	compound	KO,females
R4634	T16213	T16210	dobj	females,crossed
R4635	T16214	T16213	prep	on,females
R4636	T16215	T16216	det	a,background
R4637	T16216	T16214	pobj	background,on
R4638	T16217	T16216	nmod	C57BL,background
R4639	T16218	T16217	punct	/,C57BL
R464	T2347	T2342	prep	for,allow
R4640	T16219	T16217	nummod	6,C57BL
R4641	T16220	T16221	punct	(,Laboratory
R4642	T16221	T16213	parataxis	Laboratory,females
R4643	T16222	T16221	compound	Jackson,Laboratory
R4644	T16223	T16221	punct	", ",Laboratory
R4645	T16224	T16225	compound	Bar,Harbor
R4646	T16225	T16221	npadvmod	Harbor,Laboratory
R4647	T16226	T16221	punct	", ",Laboratory
R4648	T16227	T16221	npadvmod	Maine,Laboratory
R4649	T16228	T16221	punct	", ",Laboratory
R465	T2348	T2347	pcomp	distinguishing,for
R4650	T16229	T16230	compound	United,States
R4651	T16230	T16221	npadvmod	States,Laboratory
R4652	T16231	T16221	punct	),Laboratory
R4653	T16232	T16210	prep	to,crossed
R4654	T16233	T16234	nmod	NT,heterozygote
R4655	T16234	T16237	compound	heterozygote,males
R4656	T16235	T16233	punct	-,NT
R4657	T16236	T16233	nummod	3,NT
R4658	T16237	T16232	pobj	males,to
R4659	T16238	T16210	prep	on,crossed
R466	T2349	T2350	compound	survival,effects
R4660	T16239	T16240	det	a,background
R4661	T16240	T16238	pobj	background,on
R4662	T16241	T16242	nummod	129,Sv
R4663	T16242	T16240	compound	Sv,background
R4664	T16243	T16244	aux	to,generate
R4665	T16244	T16210	advcl	generate,crossed
R4666	T16245	T16246	amod	double,heterozygote
R4667	T16246	T16247	compound	heterozygote,animals
R4668	T16247	T16244	dobj	animals,generate
R4669	T16248	T16210	punct	.,crossed
R467	T2350	T2348	dobj	effects,distinguishing
R4670	T16250	T16251	nsubjpass	Progeny,genotyped
R4671	T16252	T16251	auxpass	was,genotyped
R4672	T16253	T16251	prep	with,genotyped
R4673	T16254	T16253	pobj	PCR,with
R4674	T16255	T16251	punct	", ",genotyped
R4675	T16256	T16251	cc	and,genotyped
R4676	T16257	T16258	nsubjpass	animals,bred
R4677	T16258	T16251	conj	bred,genotyped
R4678	T16259	T16257	amod	heterozygous,animals
R4679	T16260	T16259	prep	for,heterozygous
R468	T2351	T2350	prep	of,effects
R4680	T16261	T16262	det	both,genes
R4681	T16262	T16260	pobj	genes,for
R4682	T16263	T16258	auxpass	were,bred
R4683	T16264	T16265	aux	to,obtain
R4684	T16265	T16258	advcl	obtain,bred
R4685	T16266	T16267	det	the,KOs
R4686	T16267	T16265	dobj	KOs,obtain
R4687	T16268	T16267	amod	double,KOs
R4688	T16269	T16258	punct	.,bred
R4689	T16271	T16272	nsubj	Primers,were
R469	T2352	T2351	pobj	neurotrophins,of
R4690	T16273	T16271	acl	used,Primers
R4691	T16274	T16273	prep	for,used
R4692	T16275	T16276	det	the,locus
R4693	T16276	T16274	pobj	locus,for
R4694	T16277	T16276	compound	Bax,locus
R4695	T16278	T16272	attr	R661,were
R4696	T16279	T16278	punct	", ",R661
R4697	T16280	T16281	compound	GTT,GG
R4698	T16281	T16278	appos	GG,R661
R4699	T16282	T16281	compound	GAC,GG
R47	T477	T476	cc	and,peripheral
R470	T2353	T2348	prep	from,distinguishing
R4700	T16283	T16281	compound	CAG,GG
R4701	T16284	T16281	compound	AGT,GG
R4702	T16285	T16281	compound	GGC,GG
R4703	T16286	T16281	compound	GTA,GG
R4704	T16287	T16278	punct	;,R661
R4705	T16288	T16278	conj	R662,R661
R4706	T16289	T16288	punct	", ",R662
R4707	T16290	T16291	compound	CCG,GG
R4708	T16291	T16288	appos	GG,R662
R4709	T16292	T16291	compound	CTT,GG
R471	T2354	T2355	amod	other,effects
R4710	T16293	T16291	compound	CCA,GG
R4711	T16294	T16291	compound	TTG,GG
R4712	T16295	T16291	compound	CTC,GG
R4713	T16296	T16291	compound	AGC,GG
R4714	T16297	T16288	punct	;,R662
R4715	T16298	T16288	cc	and,R662
R4716	T16299	T16288	conj	R663,R662
R4717	T16300	T16299	punct	", ",R663
R4718	T16301	T16302	compound	GAG,ATG
R4719	T16302	T16299	appos	ATG,R663
R472	T2355	T2353	pobj	effects,from
R4720	T16303	T16302	compound	CTG,ATG
R4721	T16304	T16302	compound	ATC,ATG
R4722	T16305	T16302	compound	AGA,ATG
R4723	T16306	T16302	compound	ACC,ATG
R4724	T16307	T16302	compound	ATC,ATG
R4725	T16308	T16272	punct	.,were
R4726	T16310	T16311	nsubj	Primers,were
R4727	T16312	T16310	acl	used,Primers
R4728	T16313	T16312	prep	for,used
R4729	T16314	T16315	det	the,locus
R473	T2356	T2342	punct	.,allow
R4730	T16315	T16313	pobj	locus,for
R4731	T16316	T16315	nmod	NT,locus
R4732	T16317	T16316	punct	-,NT
R4733	T16318	T16316	nummod	3,NT
R4734	T16319	T16311	attr	NT3A,were
R4735	T16320	T16319	punct	", ",NT3A
R4736	T16321	T16322	compound	CGT,AC
R4737	T16322	T16319	appos	AC,NT3A
R4738	T16323	T16322	compound	GGT,AC
R4739	T16324	T16322	compound	GAG,AC
R474	T2358	T2359	npadvmod	Bax,deficient
R4740	T16325	T16322	compound	GTT,AC
R4741	T16326	T16322	compound	CTA,AC
R4742	T16327	T16322	compound	TTG,AC
R4743	T16328	T16322	compound	GCT,AC
R4744	T16329	T16319	punct	;,NT3A
R4745	T16330	T16319	conj	NT3B,NT3A
R4746	T16331	T16330	punct	", ",NT3B
R4747	T16332	T16333	compound	CAG,GAG
R4748	T16333	T16330	appos	GAG,NT3B
R4749	T16334	T16333	compound	AGC,GAG
R475	T2359	T2361	amod	deficient,neurons
R4750	T16335	T16333	compound	ACC,GAG
R4751	T16336	T16333	compound	CTG,GAG
R4752	T16337	T16333	compound	CCC,GAG
R4753	T16338	T16333	compound	AAA,GAG
R4754	T16339	T16333	compound	GCA,GAG
R4755	T16340	T16330	punct	;,NT3B
R4756	T16341	T16330	conj	NT3R,NT3B
R4757	T16342	T16341	punct	", ",NT3R
R4758	T16343	T16344	compound	CCT,CC
R4759	T16344	T16341	appos	CC,NT3R
R476	T2360	T2359	punct	-,deficient
R4760	T16345	T16344	compound	TGA,CC
R4761	T16346	T16344	compound	CAA,CC
R4762	T16347	T16344	compound	TAC,CC
R4763	T16348	T16344	compound	TGA,CC
R4764	T16349	T16344	compound	ATG,CC
R4765	T16350	T16341	punct	;,NT3R
R4766	T16351	T16341	cc	and,NT3R
R4767	T16352	T16341	conj	NEOF,NT3R
R4768	T16353	T16352	punct	", ",NEOF
R4769	T16354	T16355	compound	GGG,AGG
R477	T2361	T2363	nsubj	neurons,require
R4770	T16355	T16352	appos	AGG,NEOF
R4771	T16356	T16355	compound	AAC,AGG
R4772	T16357	T16355	compound	TTC,AGG
R4773	T16358	T16355	compound	CTG,AGG
R4774	T16359	T16355	compound	ACT,AGG
R4775	T16360	T16311	punct	.,were
R4776	T16362	T16363	nmod	WT,littermates
R4777	T16363	T16373	nsubjpass	littermates,used
R4778	T16364	T16362	punct	", ",WT
R4779	T16365	T16366	compound	Bax,KO
R478	T2362	T2361	amod	sensory,neurons
R4780	T16366	T16362	conj	KO,WT
R4781	T16367	T16366	punct	", ",KO
R4782	T16368	T16366	cc	and,KO
R4783	T16369	T16370	nmod	NT,KO
R4784	T16370	T16366	conj	KO,KO
R4785	T16371	T16369	punct	-,NT
R4786	T16372	T16369	nummod	3,NT
R4787	T16374	T16373	auxpass	were,used
R4788	T16375	T16373	prep	as,used
R4789	T16376	T16375	pobj	controls,as
R479	T2363	T2366	ccomp	require,used
R4790	T16377	T16373	punct	.,used
R4791	T16379	T16380	det	A,total
R4792	T16380	T16381	nsubjpass	total,analyzed
R4793	T16381	T16393	ccomp	analyzed,were
R4794	T16382	T16380	prep	of,total
R4795	T16383	T16384	nummod	11,mice
R4796	T16384	T16382	pobj	mice,of
R4797	T16385	T16386	nmod	Bax,KO
R4798	T16386	T16384	compound	KO,mice
R4799	T16387	T16385	punct	/,Bax
R48	T478	T476	conj	central,peripheral
R480	T2364	T2365	neg	no,longer
R4800	T16388	T16385	appos	NT,Bax
R4801	T16389	T16388	punct	-,NT
R4802	T16390	T16388	nummod	3,NT
R4803	T16391	T16386	amod	double,KO
R4804	T16392	T16381	auxpass	were,analyzed
R4805	T16394	T16393	punct	", ",were
R4806	T16395	T16393	prep	of,were
R4807	T16396	T16395	pobj	these,of
R4808	T16397	T16393	nsubj	nine,were
R4809	T16398	T16399	compound	P0,pups
R481	T2365	T2363	advmod	longer,require
R4810	T16399	T16393	attr	pups,were
R4811	T16400	T16393	punct	.,were
R4812	T16402	T16403	det	The,colony
R4813	T16403	T16405	nsubjpass	colony,received
R4814	T16404	T16403	compound	p75,colony
R4815	T16406	T16403	prep	on,colony
R4816	T16407	T16408	det	a,background
R4817	T16408	T16406	pobj	background,on
R4818	T16409	T16410	nummod	129,S1
R4819	T16410	T16408	compound	S1,background
R482	T2367	T2363	dobj	neurotrophins,require
R4820	T16411	T16405	auxpass	was,received
R4821	T16412	T16405	prep	from,received
R4822	T16413	T16414	compound	Jackson,Laboratory
R4823	T16414	T16412	pobj	Laboratory,from
R4824	T16415	T16405	punct	.,received
R4825	T16417	T16418	nsubj	We,used
R4826	T16419	T16420	compound	tail,DNA
R4827	T16420	T16418	dobj	DNA,used
R4828	T16421	T16422	aux	to,genotype
R4829	T16422	T16418	advcl	genotype,used
R483	T2368	T2363	prep	for,require
R4830	T16423	T16422	dobj	animals,genotype
R4831	T16424	T16422	advcl	using,genotype
R4832	T16425	T16426	det	the,primers
R4833	T16426	T16424	dobj	primers,using
R4834	T16427	T16426	appos	IMR0013,primers
R4835	T16428	T16427	punct	", ",IMR0013
R4836	T16429	T16430	compound	CTT,TC
R4837	T16430	T16427	appos	TC,IMR0013
R4838	T16431	T16430	compound	GGG,TC
R4839	T16432	T16430	compound	TGG,TC
R484	T2369	T2368	pobj	survival,for
R4840	T16433	T16430	compound	AGA,TC
R4841	T16434	T16430	compound	GGC,TC
R4842	T16435	T16430	compound	TAT,TC
R4843	T16436	T16427	punct	;,IMR0013
R4844	T16437	T16427	conj	IMR0014,IMR0013
R4845	T16438	T16437	punct	", ",IMR0014
R4846	T16439	T16440	compound	AGG,TC
R4847	T16440	T16437	appos	TC,IMR0014
R4848	T16441	T16440	compound	TGA,TC
R4849	T16442	T16440	compound	GAT,TC
R485	T2370	T2371	punct	(,White
R4850	T16443	T16440	compound	GAC,TC
R4851	T16444	T16440	compound	AGG,TC
R4852	T16445	T16440	compound	AGA,TC
R4853	T16446	T16437	punct	(,IMR0014
R4854	T16447	T16448	amod	generic,primers
R4855	T16448	T16437	appos	primers,IMR0014
R4856	T16449	T16448	compound	neo,primers
R4857	T16450	T16437	punct	),IMR0014
R4858	T16451	T16437	punct	;,IMR0014
R4859	T16452	T16437	conj	IMR0710,IMR0014
R486	T2371	T2363	meta	White,require
R4860	T16453	T16452	punct	", ",IMR0710
R4861	T16454	T16455	compound	TGT,GAG
R4862	T16455	T16452	appos	GAG,IMR0710
R4863	T16456	T16455	compound	TAC,GAG
R4864	T16457	T16455	compound	GTT,GAG
R4865	T16458	T16455	compound	CTC,GAG
R4866	T16459	T16455	compound	TGA,GAG
R4867	T16460	T16455	compound	CGT,GAG
R4868	T16461	T16455	compound	GGT,GAG
R4869	T16462	T16452	punct	;,IMR0710
R487	T2372	T2371	nmod	et,White
R4870	T16463	T16452	cc	and,IMR0710
R4871	T16464	T16452	conj	IMR0711,IMR0710
R4872	T16465	T16464	punct	", ",IMR0711
R4873	T16466	T16467	compound	TCA,TC
R4874	T16467	T16464	appos	TC,IMR0711
R4875	T16468	T16467	compound	GCC,TC
R4876	T16469	T16467	compound	CAG,TC
R4877	T16470	T16467	compound	GGT,TC
R4878	T16471	T16467	compound	GTG,TC
R4879	T16472	T16467	compound	CAC,TC
R488	T2373	T2371	nmod	al.,White
R4880	T16473	T16474	punct	(,locus
R4881	T16474	T16464	appos	locus,IMR0711
R4882	T16475	T16474	compound	p75,locus
R4883	T16476	T16464	punct	),IMR0711
R4884	T16477	T16418	punct	.,used
R4885	T16479	T16480	prep	For,considered
R4886	T16481	T16482	amod	embryonic,experiments
R4887	T16482	T16479	pobj	experiments,For
R4888	T16483	T16480	punct	", ",considered
R4889	T16484	T16480	nsubjpass	day,considered
R489	T2374	T2371	nummod	1998,White
R4890	T16485	T16484	prep	of,day
R4891	T16486	T16487	compound	plug,positivity
R4892	T16487	T16485	pobj	positivity,of
R4893	T16488	T16480	auxpass	was,considered
R4894	T16489	T16480	oprd	E0,considered
R4895	T16490	T16480	punct	.,considered
R4896	T16492	T16493	nsubjpass	All,approved
R4897	T16494	T16492	prep	of,All
R4898	T16495	T16496	det	the,protocols
R4899	T16496	T16494	pobj	protocols,of
R49	T480	T475	prep	from,axons
R490	T2375	T2371	punct	;,White
R4900	T16497	T16496	acl	used,protocols
R4901	T16498	T16497	prep	in,used
R4902	T16499	T16500	det	this,study
R4903	T16500	T16498	pobj	study,in
R4904	T16501	T16493	auxpass	were,approved
R4905	T16502	T16493	agent	by,approved
R4906	T16503	T16504	det	the,Committee
R4907	T16504	T16502	pobj	Committee,by
R4908	T16505	T16506	nmod	Louisiana,University
R4909	T16506	T16508	nmod	University,Center
R491	T2376	T2371	nmod	Patel,White
R4910	T16507	T16506	nmod	State,University
R4911	T16508	T16504	nmod	Center,Committee
R4912	T16509	T16510	nmod	Health,Sciences
R4913	T16510	T16508	nmod	Sciences,Center
R4914	T16511	T16512	nmod	Institutional,Animal
R4915	T16512	T16513	nmod	Animal,Care
R4916	T16513	T16504	nmod	Care,Committee
R4917	T16514	T16513	cc	and,Care
R4918	T16515	T16513	conj	Use,Care
R4919	T16516	T16493	cc	and,approved
R492	T2377	T2371	nmod	et,White
R4920	T16517	T16493	conj	conformed,approved
R4921	T16518	T16517	prep	to,conformed
R4922	T16519	T16520	det	the,guidelines
R4923	T16520	T16518	pobj	guidelines,to
R4924	T16521	T16522	nmod	National,Institutes
R4925	T16522	T16520	nmod	Institutes,guidelines
R4926	T16523	T16522	prep	of,Institutes
R4927	T16524	T16523	pobj	Health,of
R4928	T16525	T16520	prep	for,guidelines
R4929	T16526	T16525	pobj	use,for
R493	T2378	T2371	nmod	al.,White
R4930	T16527	T16526	prep	of,use
R4931	T16528	T16529	amod	experimental,animals
R4932	T16529	T16527	pobj	animals,of
R4933	T16530	T16493	punct	.,approved
R4934	T16880	T16881	compound	TrkA,TrkC
R4935	T16881	T16883	compound	TrkC,immunohistochemistry
R4936	T16882	T16881	punct	/,TrkC
R4937	T16884	T16883	punct	.,immunohistochemistry
R4938	T16886	T16887	amod	Frozen,sections
R4939	T16887	T16890	nsubjpass	sections,blocked
R494	T2379	T2371	nummod	2000,White
R4940	T16888	T16889	amod	spinal,cord
R4941	T16889	T16887	compound	cord,sections
R4942	T16891	T16887	punct	(,sections
R4943	T16892	T16893	nummod	10,μm
R4944	T16893	T16894	npadvmod	μm,thick
R4945	T16894	T16887	amod	thick,sections
R4946	T16895	T16887	punct	),sections
R4947	T16896	T16890	auxpass	were,blocked
R4948	T16897	T16890	cc	and,blocked
R4949	T16898	T16890	conj	incubated,blocked
R495	T2380	T2371	punct	),White
R4950	T16899	T16898	prep	in,incubated
R4951	T16900	T16901	det	a,cocktail
R4952	T16901	T16899	pobj	cocktail,in
R4953	T16902	T16901	prep	of,cocktail
R4954	T16903	T16902	pobj	rabbit,of
R4955	T16904	T16903	amod	anti-TrkA,rabbit
R4956	T16905	T16903	cc	and,rabbit
R4957	T16906	T16907	nmod	goat,antibodies
R4958	T16907	T16903	conj	antibodies,rabbit
R4959	T16908	T16906	amod	anti-TrkC,goat
R496	T2381	T2366	punct	", ",used
R4960	T16909	T16910	punct	(,gift
R4961	T16910	T16907	parataxis	gift,antibodies
R4962	T16911	T16910	prep	of,gift
R4963	T16912	T16913	compound	Dr.,Reichardt
R4964	T16913	T16911	pobj	Reichardt,of
R4965	T16914	T16910	punct	;,gift
R4966	T16915	T16910	meta	Huang,gift
R4967	T16916	T16915	nmod	et,Huang
R4968	T16917	T16915	nmod	al.,Huang
R4969	T16918	T16915	nummod	1999,Huang
R497	T2382	T2366	advmod	thus,used
R4970	T16919	T16910	punct	),gift
R4971	T16920	T16898	punct	", ",incubated
R4972	T16921	T16898	conj	followed,incubated
R4973	T16922	T16921	agent	by,followed
R4974	T16923	T16924	det	a,cocktail
R4975	T16924	T16922	pobj	cocktail,by
R4976	T16925	T16924	prep	of,cocktail
R4977	T16926	T16927	npadvmod	CY3,conjugated
R4978	T16927	T16928	amod	conjugated,donkey
R4979	T16928	T16925	pobj	donkey,of
R498	T2383	T2366	nsubjpass	they,used
R4980	T16929	T16928	amod	anti-rabbit,donkey
R4981	T16930	T16928	cc	and,donkey
R4982	T16931	T16932	npadvmod	FITC,conjugated
R4983	T16932	T16933	amod	conjugated,donkey
R4984	T16933	T16934	nmod	donkey,antibodies
R4985	T16934	T16928	conj	antibodies,donkey
R4986	T16935	T16933	amod	anti-goat,donkey
R4987	T16936	T16937	punct	(,Chemicon
R4988	T16937	T16924	parataxis	Chemicon,cocktail
R4989	T16938	T16937	punct	", ",Chemicon
R499	T2384	T2366	aux	can,used
R4990	T16939	T16937	npadvmod	Temecula,Chemicon
R4991	T16940	T16937	punct	", ",Chemicon
R4992	T16941	T16937	npadvmod	California,Chemicon
R4993	T16942	T16937	punct	", ",Chemicon
R4994	T16943	T16944	compound	United,States
R4995	T16944	T16937	npadvmod	States,Chemicon
R4996	T16945	T16937	punct	),Chemicon
R4997	T16946	T16924	prep	in,cocktail
R4998	T16947	T16948	det	the,presence
R4999	T16948	T16946	pobj	presence,in
R5	T432	T424	auxpass	is,required
R50	T481	T482	amod	dorsal,root
R500	T2385	T2366	auxpass	be,used
R5000	T16949	T16948	prep	of,presence
R5001	T16950	T16951	nummod	0.3,%
R5002	T16951	T16952	compound	%,TritonX
R5003	T16952	T16949	pobj	TritonX,of
R5004	T16953	T16952	punct	-,TritonX
R5005	T16954	T16952	nummod	100,TritonX
R5006	T16955	T16952	cc	and,TritonX
R5007	T16956	T16957	nummod	10,%
R5008	T16957	T16958	nmod	%,serum
R5009	T16958	T16952	conj	serum,TritonX
R501	T2386	T2387	aux	to,examine
R5010	T16959	T16958	amod	normal,serum
R5011	T16960	T16958	compound	donkey,serum
R5012	T16961	T16890	punct	.,blocked
R5013	T16963	T16964	prep	For,reacted
R5014	T16965	T16966	compound	PV,immunohistochemistry
R5015	T16966	T16963	pobj	immunohistochemistry,For
R5016	T16967	T16964	punct	", ",reacted
R5017	T16968	T16964	nsubjpass	sections,reacted
R5018	T16969	T16964	auxpass	were,reacted
R5019	T16970	T16964	prep	with,reacted
R502	T2387	T2366	advcl	examine,used
R5020	T16971	T16972	amod	monoclonal,antibody
R5021	T16972	T16970	pobj	antibody,with
R5022	T16973	T16972	nmod	mouse,antibody
R5023	T16974	T16972	amod	anti-PV,antibody
R5024	T16975	T16976	punct	(,Sigma
R5025	T16976	T16972	parataxis	Sigma,antibody
R5026	T16977	T16976	punct	", ",Sigma
R5027	T16978	T16979	compound	St.,Louis
R5028	T16979	T16976	npadvmod	Louis,Sigma
R5029	T16980	T16976	punct	", ",Sigma
R503	T2388	T2389	amod	axonal,effects
R5030	T16981	T16976	npadvmod	Missouri,Sigma
R5031	T16982	T16976	punct	", ",Sigma
R5032	T16983	T16984	compound	United,States
R5033	T16984	T16976	npadvmod	States,Sigma
R5034	T16985	T16976	punct	),Sigma
R5035	T16986	T16964	punct	", ",reacted
R5036	T16987	T16964	cc	and,reacted
R5037	T16988	T16964	conj	developed,reacted
R5038	T16989	T16988	agent	by,developed
R5039	T16990	T16991	nmod	Vector,fluorescein
R504	T2389	T2387	dobj	effects,examine
R5040	T16991	T16992	nmod	fluorescein,kit
R5041	T16992	T16989	pobj	kit,by
R5042	T16993	T16992	nmod	mouse,kit
R5043	T16994	T16993	prep	on,mouse
R5044	T16995	T16994	pobj	mouse,on
R5045	T16996	T16997	punct	(,Laboratories
R5046	T16997	T16992	parataxis	Laboratories,kit
R5047	T16998	T16997	compound	Vector,Laboratories
R5048	T16999	T16997	punct	", ",Laboratories
R5049	T17000	T16997	npadvmod	Burlingame,Laboratories
R505	T2390	T2366	punct	.,used
R5050	T17001	T16997	punct	", ",Laboratories
R5051	T17002	T16997	npadvmod	California,Laboratories
R5052	T17003	T16997	punct	", ",Laboratories
R5053	T17004	T17005	compound	United,States
R5054	T17005	T16997	npadvmod	States,Laboratories
R5055	T17006	T16997	punct	),Laboratories
R5056	T17007	T16964	punct	.,reacted
R5057	T17009	T17010	prep	For,counted
R5058	T17011	T17012	compound	quantification,purposes
R5059	T17012	T17009	pobj	purposes,For
R506	T2392	T2393	nsubj	We,bred
R5060	T17013	T17010	punct	", ",counted
R5061	T17014	T17015	npadvmod	TrkA,labeled
R5062	T17015	T17020	amod	labeled,cells
R5063	T17016	T17014	punct	-,TrkA
R5064	T17017	T17014	cc	and,TrkA
R5065	T17018	T17014	conj	TrkC,TrkA
R5066	T17019	T17015	punct	-,labeled
R5067	T17020	T17010	nsubjpass	cells,counted
R5068	T17021	T17020	prep	from,cells
R5069	T17022	T17023	nummod	four,DRGs
R507	T2394	T2395	nmod	NT,heterozygote
R5070	T17023	T17021	pobj	DRGs,from
R5071	T17024	T17023	amod	different,DRGs
R5072	T17025	T17023	prep	of,DRGs
R5073	T17026	T17027	det	each,genotype
R5074	T17027	T17025	pobj	genotype,of
R5075	T17028	T17027	cc	and,genotype
R5076	T17029	T17027	conj	age,genotype
R5077	T17030	T17027	acl	studied,genotype
R5078	T17031	T17010	auxpass	were,counted
R5079	T17032	T17010	punct	", ",counted
R508	T2395	T2393	dobj	heterozygote,bred
R5080	T17033	T17010	cc	and,counted
R5081	T17034	T17035	nsubj	ratios,plotted
R5082	T17035	T17010	conj	plotted,counted
R5083	T17036	T17010	punct	.,counted
R5084	T17352	T17353	compound	Muscle,spindle
R5085	T17353	T17354	compound	spindle,detection
R5086	T17355	T17354	punct	.,detection
R5087	T17357	T17358	compound	Gastrocnemius,muscle
R5088	T17358	T17359	nsubjpass	muscle,dissected
R5089	T17360	T17359	auxpass	was,dissected
R509	T2396	T2394	punct	-,NT
R5090	T17361	T17359	prt	out,dissected
R5091	T17362	T17359	prep	in,dissected
R5092	T17363	T17364	compound	P0,pups
R5093	T17364	T17362	pobj	pups,in
R5094	T17365	T17359	cc	and,dissected
R5095	T17366	T17359	conj	sectioned,dissected
R5096	T17367	T17366	advmod	longitudinally,sectioned
R5097	T17368	T17359	punct	", ",dissected
R5098	T17369	T17359	cc	or,dissected
R5099	T17370	T17359	punct	", ",dissected
R51	T482	T483	compound	root,ganglia
R510	T2397	T2394	nummod	3,NT
R5100	T17371	T17372	prep	in,sectioned
R5101	T17372	T17359	conj	sectioned,dissected
R5102	T17373	T17374	det	some,cases
R5103	T17374	T17371	pobj	cases,in
R5104	T17375	T17372	punct	", ",sectioned
R5105	T17376	T17377	det	the,leg
R5106	T17377	T17372	nsubjpass	leg,sectioned
R5107	T17378	T17377	amod	whole,leg
R5108	T17379	T17377	prep	at,leg
R5109	T17380	T17381	det	the,level
R511	T2398	T2395	cc	and,heterozygote
R5110	T17381	T17379	pobj	level,at
R5111	T17382	T17381	prep	of,level
R5112	T17383	T17384	compound	gastrocnemius,muscle
R5113	T17384	T17382	pobj	muscle,of
R5114	T17385	T17384	prep	with,muscle
R5115	T17386	T17387	amod	tibial,nerve
R5116	T17387	T17385	pobj	nerve,with
R5117	T17388	T17372	auxpass	was,sectioned
R5118	T17389	T17372	prep	in,sectioned
R5119	T17390	T17391	compound	cross,section
R512	T2399	T2400	nmod	Bax,knockout
R5120	T17391	T17389	pobj	section,in
R5121	T17392	T17372	punct	.,sectioned
R5122	T17394	T17395	nsubj	Sections,incubated
R5123	T17396	T17395	aux	were,incubated
R5124	T17397	T17395	prep	with,incubated
R5125	T17398	T17399	amod	monoclonal,antibody
R5126	T17399	T17397	pobj	antibody,with
R5127	T17400	T17399	compound	S46,antibody
R5128	T17401	T17402	punct	(,gift
R5129	T17402	T17399	parataxis	gift,antibody
R513	T2400	T2401	nmod	knockout,mice
R5130	T17403	T17402	prep	of,gift
R5131	T17404	T17405	compound	Dr.,Stockdale
R5132	T17405	T17403	pobj	Stockdale,of
R5133	T17406	T17402	punct	),gift
R5134	T17407	T17399	amod	reactive,antibody
R5135	T17408	T17407	prep	to,reactive
R5136	T17409	T17410	det	the,isoform
R5137	T17410	T17408	pobj	isoform,to
R5138	T17411	T17412	npadvmod	spindle,specific
R5139	T17412	T17410	amod	specific,isoform
R514	T2401	T2395	conj	mice,heterozygote
R5140	T17413	T17412	punct	-,specific
R5141	T17414	T17415	amod	slow,tonic
R5142	T17415	T17410	nmod	tonic,isoform
R5143	T17416	T17415	punct	-,tonic
R5144	T17417	T17410	nmod	myosin,isoform
R5145	T17418	T17419	amod	heavy,chain
R5146	T17419	T17410	compound	chain,isoform
R5147	T17420	T17395	cc	and,incubated
R5148	T17421	T17395	conj	developed,incubated
R5149	T17422	T17421	prep	by,developed
R515	T2402	T2400	punct	(,knockout
R5150	T17423	T17424	nmod	Vector,kit
R5151	T17424	T17422	pobj	kit,by
R5152	T17425	T17424	nmod	mouse,kit
R5153	T17426	T17425	prep	on,mouse
R5154	T17427	T17426	pobj	mouse,on
R5155	T17428	T17429	mark	as,described
R5156	T17429	T17421	advcl	described,developed
R5157	T17430	T17429	advmod	above,described
R5158	T17431	T17395	punct	", ",incubated
R5159	T17432	T17395	advcl	followed,incubated
R516	T2403	T2400	appos	KO,knockout
R5160	T17433	T17432	agent	by,followed
R5161	T17434	T17435	nmod	rabbit,antibody
R5162	T17435	T17433	pobj	antibody,by
R5163	T17436	T17437	amod	anti-NF,M
R5164	T17437	T17435	compound	M,antibody
R5165	T17438	T17437	punct	-,M
R5166	T17439	T17440	punct	(,Chemicon
R5167	T17440	T17435	parataxis	Chemicon,antibody
R5168	T17441	T17440	punct	),Chemicon
R5169	T17442	T17435	cc	and,antibody
R517	T2404	T2401	punct	),mice
R5170	T17443	T17444	nmod	CY3,antibody
R5171	T17444	T17435	conj	antibody,antibody
R5172	T17445	T17444	amod	conjugated,antibody
R5173	T17446	T17444	nmod	goat,antibody
R5174	T17447	T17444	amod	anti-rabbit,antibody
R5175	T17448	T17449	punct	(,Chemicon
R5176	T17449	T17444	parataxis	Chemicon,antibody
R5177	T17450	T17449	punct	),Chemicon
R5178	T17451	T17432	prep	in,followed
R5179	T17452	T17453	det	a,protocol
R518	T2405	T2406	aux	to,obtain
R5180	T17453	T17451	pobj	protocol,in
R5181	T17454	T17453	amod	sequential,protocol
R5182	T17455	T17456	amod	double,labeling
R5183	T17456	T17453	compound	labeling,protocol
R5184	T17457	T17456	punct	-,labeling
R5185	T17458	T17395	punct	.,incubated
R5186	T17460	T17461	prep	In,placed
R5187	T17462	T17463	det	another,method
R5188	T17463	T17460	pobj	method,In
R5189	T17464	T17461	punct	", ",placed
R519	T2406	T2393	advcl	obtain,bred
R5190	T17465	T17466	compound	DiI,crystals
R5191	T17466	T17461	nsubjpass	crystals,placed
R5192	T17467	T17461	auxpass	were,placed
R5193	T17468	T17461	prep	in,placed
R5194	T17469	T17468	pobj	DRGs,in
R5195	T17470	T17469	prep	of,DRGs
R5196	T17471	T17472	compound	E17,embryos
R5197	T17472	T17470	pobj	embryos,of
R5198	T17473	T17472	prep	from,embryos
R5199	T17474	T17475	amod	different,genotypes
R52	T483	T480	pobj	ganglia,from
R520	T2407	T2406	dobj	mice,obtain
R5200	T17475	T17473	pobj	genotypes,from
R5201	T17476	T17477	punct	(,2
R5202	T17477	T17472	parataxis	2,embryos
R5203	T17478	T17477	nsubj	n,2
R5204	T17479	T17477	punct	=,2
R5205	T17480	T17477	punct	),2
R5206	T17481	T17461	punct	", ",placed
R5207	T17482	T17461	cc	and,placed
R5208	T17483	T17484	det	the,muscle
R5209	T17484	T17486	nsubjpass	muscle,isolated
R521	T2408	T2407	prep	with,mice
R5210	T17485	T17484	compound	gastrocnemius,muscle
R5211	T17486	T17461	conj	isolated,placed
R5212	T17487	T17486	auxpass	was,isolated
R5213	T17488	T17486	cc	and,isolated
R5214	T17489	T17486	conj	sectioned,isolated
R5215	T17490	T17489	prep	into,sectioned
R5216	T17491	T17492	nummod	40,μm
R5217	T17492	T17494	npadvmod	μm,thick
R5218	T17493	T17492	punct	-,μm
R5219	T17494	T17496	amod	thick,slices
R522	T2409	T2410	amod	double,KO
R5220	T17495	T17494	punct	-,thick
R5221	T17496	T17490	pobj	slices,into
R5222	T17497	T17489	prep	on,sectioned
R5223	T17498	T17499	det	a,vibratome
R5224	T17499	T17497	pobj	vibratome,on
R5225	T17500	T17486	punct	.,isolated
R5226	T17771	T17772	compound	DiI,labeling
R5227	T17773	T17772	punct	.,labeling
R5228	T17775	T17776	amod	Spinal,cords
R5229	T17776	T17777	nsubjpass	cords,dissected
R523	T2410	T2408	pobj	KO,with
R5230	T17778	T17777	auxpass	were,dissected
R5231	T17779	T17777	prt	out,dissected
R5232	T17780	T17781	mark	with,attached
R5233	T17781	T17777	advcl	attached,dissected
R5234	T17782	T17783	det	the,DRGs
R5235	T17783	T17781	nsubj	DRGs,attached
R5236	T17784	T17777	punct	", ",dissected
R5237	T17785	T17786	compound	motor,root
R5238	T17786	T17787	nsubjpass	root,cut
R5239	T17787	T17777	conj	cut,dissected
R524	T2411	T2410	prep	of,KO
R5240	T17788	T17787	auxpass	was,cut
R5241	T17789	T17790	aux	to,prevent
R5242	T17790	T17787	advcl	prevent,cut
R5243	T17791	T17790	dobj	backfilling,prevent
R5244	T17792	T17791	prep	of,backfilling
R5245	T17793	T17794	compound	motor,neurons
R5246	T17794	T17792	pobj	neurons,of
R5247	T17795	T17787	punct	", ",cut
R5248	T17796	T17787	cc	and,cut
R5249	T17797	T17798	nsubjpass	crystals,inserted
R525	T2412	T2413	preconj	both,NT
R5250	T17798	T17787	conj	inserted,cut
R5251	T17799	T17797	prep	of,crystals
R5252	T17800	T17801	nummod	1,perchlorate
R5253	T17801	T17799	pobj	perchlorate,of
R5254	T17802	T17800	punct	",",1
R5255	T17803	T17800	appos	1,1
R5256	T17804	T17803	punct	′,1
R5257	T17805	T17801	punct	-,perchlorate
R5258	T17806	T17801	nmod	dioctadecyl,perchlorate
R5259	T17807	T17801	punct	-,perchlorate
R526	T2413	T2414	nmod	NT,genes
R5260	T17808	T17801	nummod	3,perchlorate
R5261	T17809	T17808	punct	",",3
R5262	T17810	T17808	appos	3,3
R5263	T17811	T17808	punct	",",3
R5264	T17812	T17808	appos	3,3
R5265	T17813	T17812	punct	′,3
R5266	T17814	T17808	punct	",",3
R5267	T17815	T17808	appos	3,3
R5268	T17816	T17815	punct	′,3
R5269	T17817	T17801	punct	-,perchlorate
R527	T2414	T2411	pobj	genes,of
R5270	T17818	T17801	compound	tetramethylindocarbocyanine,perchlorate
R5271	T17819	T17820	punct	(,Probes
R5272	T17820	T17797	parataxis	Probes,crystals
R5273	T17821	T17820	dep	DiI,Probes
R5274	T17822	T17820	punct	;,Probes
R5275	T17823	T17820	compound	Molecular,Probes
R5276	T17824	T17820	punct	", ",Probes
R5277	T17825	T17820	npadvmod	Eugene,Probes
R5278	T17826	T17820	punct	", ",Probes
R5279	T17827	T17820	npadvmod	Oregon,Probes
R528	T2415	T2413	punct	-,NT
R5280	T17828	T17820	punct	", ",Probes
R5281	T17829	T17830	compound	United,States
R5282	T17830	T17820	npadvmod	States,Probes
R5283	T17831	T17820	punct	),Probes
R5284	T17832	T17798	auxpass	were,inserted
R5285	T17833	T17798	prep	in,inserted
R5286	T17834	T17833	pobj	DRGs,in
R5287	T17835	T17798	punct	.,inserted
R5288	T17837	T17838	amod	Labeled,cords
R5289	T17838	T17840	nsubjpass	cords,incubated
R529	T2416	T2413	nummod	3,NT
R5290	T17839	T17838	amod	spinal,cords
R5291	T17841	T17840	auxpass	were,incubated
R5292	T17842	T17840	prep	at,incubated
R5293	T17843	T17844	nummod	37,°C
R5294	T17844	T17842	pobj	°C,at
R5295	T17845	T17840	prep	for,incubated
R5296	T17846	T17847	nummod	8,d
R5297	T17847	T17845	pobj	d,for
R5298	T17848	T17840	cc	and,incubated
R5299	T17849	T17840	conj	sectioned,incubated
R53	T484	T485	amod	proper,trajectories
R530	T2417	T2413	cc	and,NT
R5300	T17850	T17849	prep	on,sectioned
R5301	T17851	T17852	det	a,vibrotome
R5302	T17852	T17850	pobj	vibrotome,on
R5303	T17853	T17849	prep	at,sectioned
R5304	T17854	T17855	nummod	100,μm
R5305	T17855	T17853	pobj	μm,at
R5306	T17856	T17840	punct	.,incubated
R5307	T17858	T17859	nsubjpass	Sections,observed
R5308	T17860	T17859	auxpass	were,observed
R5309	T17861	T17859	prep	under,observed
R531	T2418	T2413	conj	Bax,NT
R5310	T17862	T17863	det	the,microscope
R5311	T17863	T17861	pobj	microscope,under
R5312	T17864	T17863	amod	fluorescent,microscope
R5313	T17865	T17859	cc	and,observed
R5314	T17866	T17859	conj	photographed,observed
R5315	T17867	T17859	punct	", ",observed
R5316	T17868	T17859	cc	and,observed
R5317	T17869	T17870	nsubjpass	images,transferred
R5318	T17870	T17859	conj	transferred,observed
R5319	T17871	T17870	auxpass	were,transferred
R532	T2419	T2393	punct	", ",bred
R5320	T17872	T17870	prep	to,transferred
R5321	T17873	T17874	compound	Adobe,Photoshop
R5322	T17874	T17872	pobj	Photoshop,to
R5323	T17875	T17870	punct	", ",transferred
R5324	T17876	T17870	conj	inverted,transferred
R5325	T17877	T17876	punct	", ",inverted
R5326	T17878	T17876	cc	and,inverted
R5327	T17879	T17876	conj	adjusted,inverted
R5328	T17880	T17879	prep	for,adjusted
R5329	T17881	T17880	pobj	brightness,for
R533	T2420	T2393	cc	and,bred
R5330	T17882	T17881	cc	and,brightness
R5331	T17883	T17881	conj	contrast,brightness
R5332	T17884	T17870	punct	.,transferred
R5333	T17887	T17886	prep	in,Photoconverted
R5334	T17888	T17889	nummod	0.15,%
R5335	T17889	T17890	compound	%,DAB
R5336	T17890	T17887	pobj	DAB,in
R5337	T17891	T17892	punct	(,Sigma
R5338	T17892	T17890	parataxis	Sigma,DAB
R5339	T17893	T17894	nummod	3,diaminobenzidine
R534	T2421	T2393	conj	examined,bred
R5340	T17894	T17892	dep	diaminobenzidine,Sigma
R5341	T17895	T17893	punct	",",3
R5342	T17896	T17893	appos	3,3
R5343	T17897	T17896	punct	′,3
R5344	T17898	T17894	punct	-,diaminobenzidine
R5345	T17899	T17892	punct	;,Sigma
R5346	T17900	T17892	punct	),Sigma
R5347	T17901	T17886	prep	in,Photoconverted
R5348	T17902	T17903	nummod	0.1,M
R5349	T17903	T17904	compound	M,buffer
R535	T2422	T2423	amod	proprioceptive,projections
R5350	T17904	T17901	pobj	buffer,in
R5351	T17905	T17904	compound	Tris,buffer
R5352	T17906	T17904	punct	(,buffer
R5353	T17907	T17904	npadvmod	pH,buffer
R5354	T17908	T17907	nummod	8.2,pH
R5355	T17909	T17904	punct	),buffer
R5356	T17910	T17886	punct	.,Photoconverted
R5357	T18468	T18469	advmod	In,vitro
R5358	T18469	T18470	amod	vitro,assay
R5359	T18471	T18470	compound	co-culture,assay
R536	T2423	T2421	dobj	projections,examined
R5360	T18472	T18470	punct	.,assay
R5361	T18474	T18475	compound	DRG,explants
R5362	T18475	T18476	nsubjpass	explants,derived
R5363	T18477	T18476	auxpass	were,derived
R5364	T18478	T18476	prep	from,derived
R5365	T18479	T18480	nmod	Swiss,Webster
R5366	T18480	T18481	nmod	Webster,embryos
R5367	T18481	T18478	pobj	embryos,from
R5368	T18482	T18480	punct	", ",Webster
R5369	T18483	T18484	npadvmod	Bax,null
R537	T2424	T2423	amod	axonal,projections
R5370	T18484	T18480	conj	null,Webster
R5371	T18485	T18484	punct	", ",null
R5372	T18486	T18484	cc	and,null
R5373	T18487	T18488	npadvmod	p75,null
R5374	T18488	T18484	conj	null,null
R5375	T18489	T18481	compound	mouse,embryos
R5376	T18490	T18491	punct	(,E13
R5377	T18491	T18481	parataxis	E13,embryos
R5378	T18492	T18491	punct	),E13
R5379	T18493	T18476	punct	.,derived
R538	T2425	T2393	punct	.,bred
R5380	T18495	T18496	prep	For,dissected
R5381	T18497	T18498	compound	collagen,matrix
R5382	T18498	T18499	compound	matrix,assays
R5383	T18499	T18495	pobj	assays,For
R5384	T18500	T18496	punct	", ",dissected
R5385	T18501	T18496	nsubjpass	DRGs,dissected
R5386	T18502	T18496	auxpass	were,dissected
R5387	T18503	T18496	prt	out,dissected
R5388	T18504	T18496	prep	under,dissected
R5389	T18505	T18506	det	a,stereomicroscope
R539	T2427	T2428	det	All,KOs
R5390	T18506	T18504	pobj	stereomicroscope,under
R5391	T18507	T18496	advcl	using,dissected
R5392	T18508	T18509	compound	tungsten,needles
R5393	T18509	T18507	dobj	needles,using
R5394	T18510	T18496	punct	.,dissected
R5395	T18512	T18513	compound	Collagen,matrix
R5396	T18513	T18514	nsubjpass	matrix,prepared
R5397	T18515	T18514	auxpass	was,prepared
R5398	T18516	T18514	prep	with,prepared
R5399	T18517	T18518	nummod	430,μl
R54	T485	T479	dobj	trajectories,follow
R540	T2428	T2434	nsubj	KOs,died
R5400	T18518	T18516	pobj	μl,with
R5401	T18519	T18518	prep	of,μl
R5402	T18520	T18519	pobj	collagen,of
R5403	T18521	T18522	punct	(,Sigma
R5404	T18522	T18518	parataxis	Sigma,μl
R5405	T18523	T18524	nummod	3,mg
R5406	T18524	T18522	dep	mg,Sigma
R5407	T18525	T18526	punct	/,ml
R5408	T18526	T18524	prep	ml,mg
R5409	T18527	T18524	acl	dissolved,mg
R541	T2429	T2428	nmod	NT,KOs
R5410	T18528	T18527	prep	in,dissolved
R5411	T18529	T18530	nummod	0.1,M
R5412	T18530	T18531	nmod	M,acid
R5413	T18531	T18528	pobj	acid,in
R5414	T18532	T18531	amod	acetic,acid
R5415	T18533	T18522	punct	", ",Sigma
R5416	T18534	T18522	punct	),Sigma
R5417	T18535	T18518	punct	", ",μl
R5418	T18536	T18537	nummod	50,μl
R5419	T18537	T18518	conj	μl,μl
R542	T2430	T2429	punct	-,NT
R5420	T18538	T18537	prep	of,μl
R5421	T18539	T18540	nummod	10,DMEM
R5422	T18540	T18542	compound	DMEM,medium
R5423	T18541	T18540	compound	X,DMEM
R5424	T18542	T18538	pobj	medium,of
R5425	T18543	T18537	punct	", ",μl
R5426	T18544	T18537	cc	and,μl
R5427	T18545	T18546	nummod	2.5,μl
R5428	T18546	T18537	conj	μl,μl
R5429	T18547	T18546	prep	of,μl
R543	T2431	T2429	nummod	3,NT
R5430	T18548	T18549	nummod	0.8,M
R5431	T18549	T18550	compound	M,NaCa2
R5432	T18550	T18547	pobj	NaCa2,of
R5433	T18551	T18514	punct	", ",prepared
R5434	T18552	T18514	cc	and,prepared
R5435	T18553	T18554	det	the,pH
R5436	T18554	T18555	nsubjpass	pH,adjusted
R5437	T18555	T18514	conj	adjusted,prepared
R5438	T18556	T18555	auxpass	was,adjusted
R5439	T18557	T18555	prep	to,adjusted
R544	T2432	T2429	cc	and,NT
R5440	T18558	T18557	pobj	7.5,to
R5441	T18559	T18555	punct	.,adjusted
R5442	T18561	T18562	amod	Individual,explants
R5443	T18562	T18564	nsubjpass	explants,placed
R5444	T18563	T18562	compound	ganglion,explants
R5445	T18565	T18564	auxpass	were,placed
R5446	T18566	T18564	prep	in,placed
R5447	T18567	T18568	nummod	24,well
R5448	T18568	T18570	compound	well,plates
R5449	T18569	T18568	punct	-,well
R545	T2433	T2429	conj	double,NT
R5450	T18570	T18566	pobj	plates,in
R5451	T18571	T18564	cc	and,placed
R5452	T18572	T18564	conj	covered,placed
R5453	T18573	T18572	prep	with,covered
R5454	T18574	T18575	advmod	freshly,prepared
R5455	T18575	T18576	amod	prepared,collagen
R5456	T18576	T18573	pobj	collagen,with
R5457	T18577	T18564	punct	.,placed
R5458	T18579	T18580	compound	Sepharose,beads
R5459	T18580	T18581	nsubjpass	beads,used
R546	T2435	T2434	prep	within,died
R5460	T18582	T18580	prep	with,beads
R5461	T18583	T18584	det	an,diameter
R5462	T18584	T18582	pobj	diameter,with
R5463	T18585	T18584	amod	average,diameter
R5464	T18586	T18584	prep	of,diameter
R5465	T18587	T18588	nummod	150,μm
R5466	T18588	T18586	pobj	μm,of
R5467	T18589	T18581	auxpass	were,used
R5468	T18590	T18581	punct	.,used
R5469	T18592	T18593	nsubjpass	Beads,washed
R547	T2436	T2437	nummod	48,h
R5470	T18594	T18593	auxpass	were,washed
R5471	T18595	T18593	advmod	twice,washed
R5472	T18596	T18593	prep	with,washed
R5473	T18597	T18596	pobj	PBS,with
R5474	T18598	T18593	punct	", ",washed
R5475	T18599	T18600	dep	air,dried
R5476	T18600	T18593	conj	dried,washed
R5477	T18601	T18600	punct	", ",dried
R5478	T18602	T18600	cc	and,dried
R5479	T18603	T18600	conj	loaded,dried
R548	T2437	T2435	pobj	h,within
R5480	T18604	T18603	prep	with,loaded
R5481	T18605	T18606	nummod	10,ng
R5482	T18606	T18614	nmod	ng,NT
R5483	T18607	T18605	punct	", ",10
R5484	T18608	T18605	conj	20,10
R5485	T18609	T18608	punct	", ",20
R5486	T18610	T18608	conj	50,20
R5487	T18611	T18610	punct	", ",50
R5488	T18612	T18610	cc	or,50
R5489	T18613	T18610	conj	100,50
R549	T2438	T2437	prep	after,h
R5490	T18614	T18604	pobj	NT,with
R5491	T18615	T18616	punct	/,μl
R5492	T18616	T18606	prep	μl,ng
R5493	T18617	T18614	punct	-,NT
R5494	T18618	T18614	nummod	3,NT
R5495	T18619	T18620	punct	(,Research
R5496	T18620	T18614	parataxis	Research,NT
R5497	T18621	T18620	amod	Collaborative,Research
R5498	T18622	T18620	punct	", ",Research
R5499	T18623	T18620	npadvmod	Chemicon,Research
R55	T486	T479	cc	and,follow
R550	T2439	T2438	pobj	birth,after
R5500	T18624	T18620	punct	),Research
R5501	T18625	T18603	prep	at,loaded
R5502	T18626	T18627	nummod	4,°C
R5503	T18627	T18625	pobj	°C,at
R5504	T18628	T18603	advmod	overnight,loaded
R5505	T18629	T18603	prep	with,loaded
R5506	T18630	T18631	amod	constant,shaking
R5507	T18631	T18629	pobj	shaking,with
R5508	T18632	T18593	punct	.,washed
R5509	T18634	T18635	prep	For,loaded
R551	T2440	T2441	punct	(,Tessarollo
R5510	T18636	T18637	amod	negative,control
R5511	T18637	T18634	pobj	control,For
R5512	T18638	T18635	punct	", ",loaded
R5513	T18639	T18635	nsubjpass	beads,loaded
R5514	T18640	T18635	auxpass	were,loaded
R5515	T18641	T18635	prep	with,loaded
R5516	T18642	T18641	pobj	BSA,with
R5517	T18643	T18644	punct	(,ng
R5518	T18644	T18642	parataxis	ng,BSA
R5519	T18645	T18646	compound	10,100
R552	T2441	T2434	meta	Tessarollo,died
R5520	T18646	T18644	nummod	100,ng
R5521	T18647	T18646	punct	–,100
R5522	T18648	T18649	punct	/,μl
R5523	T18649	T18644	prep	μl,ng
R5524	T18650	T18644	punct	),ng
R5525	T18651	T18642	cc	or,BSA
R5526	T18652	T18642	conj	PBS,BSA
R5527	T18653	T18635	punct	.,loaded
R5528	T18655	T18656	preconj	Either,bead
R5529	T18656	T18662	nsubjpass	bead,implanted
R553	T2442	T2441	nmod	et,Tessarollo
R5530	T18657	T18656	det	a,bead
R5531	T18658	T18656	amod	single,bead
R5532	T18659	T18660	npadvmod	neurotrophin,loaded
R5533	T18660	T18656	amod	loaded,bead
R5534	T18661	T18660	punct	-,loaded
R5535	T18663	T18656	cc	or,bead
R5536	T18664	T18665	det	a,bead
R5537	T18665	T18656	conj	bead,bead
R5538	T18666	T18665	amod	single,bead
R5539	T18667	T18668	npadvmod	BSA,loaded
R554	T2443	T2441	nmod	al.,Tessarollo
R5540	T18668	T18665	amod	loaded,bead
R5541	T18669	T18667	punct	(,BSA
R5542	T18670	T18667	cc	or,BSA
R5543	T18671	T18667	conj	PBS,BSA
R5544	T18672	T18671	punct	),PBS
R5545	T18673	T18668	punct	–,loaded
R5546	T18674	T18662	auxpass	was,implanted
R5547	T18675	T18676	quantmod	about,"1,200"
R5548	T18676	T18679	nummod	"1,200",μm
R5549	T18677	T18676	compound	200,"1,200"
R555	T2444	T2441	nummod	1994,Tessarollo
R5550	T18678	T18676	punct	–,"1,200"
R5551	T18679	T18680	npadvmod	μm,away
R5552	T18680	T18662	advmod	away,implanted
R5553	T18681	T18680	prep	from,away
R5554	T18682	T18683	det	the,explant
R5555	T18683	T18681	pobj	explant,from
R5556	T18684	T18683	compound	ganglion,explant
R5557	T18685	T18662	punct	.,implanted
R5558	T18687	T18688	npadvmod	Collagen,embedded
R5559	T18688	T18690	amod	embedded,cultures
R556	T2445	T2441	punct	),Tessarollo
R5560	T18689	T18688	punct	-,embedded
R5561	T18690	T18691	nsubjpass	cultures,placed
R5562	T18692	T18691	auxpass	were,placed
R5563	T18693	T18691	advmod	then,placed
R5564	T18694	T18691	prep	at,placed
R5565	T18695	T18696	nummod	33,°C
R5566	T18696	T18694	pobj	°C,at
R5567	T18697	T18691	prep	for,placed
R5568	T18698	T18699	nummod	15,min
R5569	T18699	T18697	pobj	min,for
R557	T2446	T2434	punct	.,died
R5570	T18700	T18701	mark	for,harden
R5571	T18701	T18691	advcl	harden,placed
R5572	T18702	T18703	det	the,matrix
R5573	T18703	T18701	nsubj	matrix,harden
R5574	T18704	T18701	aux	to,harden
R5575	T18705	T18691	punct	.,placed
R5576	T18707	T18708	npadvmod	Serum,free
R5577	T18708	T18710	amod	free,medium
R5578	T18709	T18708	punct	-,free
R5579	T18710	T18712	nsubjpass	medium,added
R558	T2448	T2449	nsubj	We,performed
R5580	T18711	T18710	compound	culture,medium
R5581	T18713	T18712	auxpass	was,added
R5582	T18714	T18712	advmod	then,added
R5583	T18715	T18712	prep	to,added
R5584	T18716	T18717	det	each,well
R5585	T18717	T18715	pobj	well,to
R5586	T18718	T18712	punct	.,added
R5587	T18720	T18721	prep	In,added
R5588	T18722	T18720	pobj	cultures,In
R5589	T18723	T18722	prep	with,cultures
R559	T2450	T2451	nmod	TrkA,TrkC
R5590	T18724	T18725	compound	WT,DRG
R5591	T18725	T18723	pobj	DRG,with
R5592	T18726	T18725	cc	and,DRG
R5593	T18727	T18728	compound	control,beads
R5594	T18728	T18725	conj	beads,DRG
R5595	T18729	T18721	punct	", ",added
R5596	T18730	T18731	nummod	10,%
R5597	T18731	T18732	compound	%,serum
R5598	T18732	T18721	nsubjpass	serum,added
R5599	T18733	T18721	auxpass	was,added
R56	T487	T479	conj	arrive,follow
R560	T2451	T2453	nmod	TrkC,immunohistochemistry
R5600	T18734	T18735	aux	to,ensure
R5601	T18735	T18721	advcl	ensure,added
R5602	T18736	T18735	dobj	viability,ensure
R5603	T18737	T18736	prep	of,viability
R5604	T18738	T18739	det	the,explants
R5605	T18739	T18737	pobj	explants,of
R5606	T18740	T18721	punct	.,added
R5607	T18742	T18743	compound	TrkC,Fc
R5608	T18743	T18745	nsubjpass	Fc,added
R5609	T18744	T18743	punct	-,Fc
R561	T2452	T2451	punct	/,TrkC
R5610	T18746	T18747	punct	(,Pharmaceuticals
R5611	T18747	T18743	parataxis	Pharmaceuticals,Fc
R5612	T18748	T18747	compound	Regeneron,Pharmaceuticals
R5613	T18749	T18747	punct	", ",Pharmaceuticals
R5614	T18750	T18747	npadvmod	Tarrytown,Pharmaceuticals
R5615	T18751	T18747	punct	", ",Pharmaceuticals
R5616	T18752	T18753	compound	New,York
R5617	T18753	T18747	npadvmod	York,Pharmaceuticals
R5618	T18754	T18747	punct	", ",Pharmaceuticals
R5619	T18755	T18756	compound	United,States
R562	T2453	T2449	dobj	immunohistochemistry,performed
R5620	T18756	T18747	npadvmod	States,Pharmaceuticals
R5621	T18757	T18747	punct	),Pharmaceuticals
R5622	T18758	T18745	auxpass	was,added
R5623	T18759	T18760	punct	(,μg
R5624	T18760	T18745	parataxis	μg,added
R5625	T18761	T18760	nummod	20,μg
R5626	T18762	T18763	punct	/,ml
R5627	T18763	T18760	prep	ml,μg
R5628	T18764	T18760	punct	),μg
R5629	T18765	T18745	prep	into,added
R563	T2454	T2453	amod	double,immunohistochemistry
R5630	T18766	T18767	det	the,medium
R5631	T18767	T18765	pobj	medium,into
R5632	T18768	T18767	compound	culture,medium
R5633	T18769	T18745	punct	.,added
R5634	T19117	T19118	compound	Explant,co-cultures
R5635	T19120	T19121	amod	Spinal,cords
R5636	T19121	T19122	nsubjpass	cords,dissected
R5637	T19123	T19121	prep	with,cords
R5638	T19124	T19125	amod	attached,DRGs
R5639	T19125	T19123	pobj	DRGs,with
R564	T2455	T2456	punct	(,Huang
R5640	T19126	T19122	auxpass	were,dissected
R5641	T19127	T19122	prt	out,dissected
R5642	T19128	T19122	prep	from,dissected
R5643	T19129	T19130	compound	Swiss,Webster
R5644	T19130	T19131	compound	Webster,embryos
R5645	T19131	T19128	pobj	embryos,from
R5646	T19132	T19131	compound	mouse,embryos
R5647	T19133	T19131	prep	at,embryos
R5648	T19134	T19133	pobj	E13,at
R5649	T19135	T19122	punct	", ",dissected
R565	T2456	T2453	meta	Huang,immunohistochemistry
R5650	T19136	T19122	cc	and,dissected
R5651	T19137	T19122	conj	sectioned,dissected
R5652	T19138	T19137	prep	into,sectioned
R5653	T19139	T19140	nummod	300,μm
R5654	T19140	T19142	npadvmod	μm,thick
R5655	T19141	T19140	punct	-,μm
R5656	T19142	T19144	amod	thick,slices
R5657	T19143	T19142	punct	-,thick
R5658	T19144	T19138	pobj	slices,into
R5659	T19145	T19122	punct	.,dissected
R566	T2457	T2456	nmod	et,Huang
R5660	T19147	T19148	compound	Tissue,slices
R5661	T19148	T19149	nsubjpass	slices,placed
R5662	T19150	T19149	auxpass	were,placed
R5663	T19151	T19149	prep	on,placed
R5664	T19152	T19153	compound	Millicell,Inserts
R5665	T19153	T19151	pobj	Inserts,on
R5666	T19154	T19155	compound	Tissue,Culture
R5667	T19155	T19153	compound	Culture,Inserts
R5668	T19156	T19157	punct	(,Millipore
R5669	T19157	T19153	parataxis	Millipore,Inserts
R567	T2458	T2456	nmod	al.,Huang
R5670	T19158	T19157	punct	", ",Millipore
R5671	T19159	T19157	npadvmod	Billrica,Millipore
R5672	T19160	T19157	punct	", ",Millipore
R5673	T19161	T19157	npadvmod	Massachusetts,Millipore
R5674	T19162	T19157	punct	", ",Millipore
R5675	T19163	T19164	compound	United,States
R5676	T19164	T19157	npadvmod	States,Millipore
R5677	T19165	T19157	punct	),Millipore
R5678	T19166	T19149	punct	.,placed
R5679	T19168	T19169	npadvmod	NT,loaded
R568	T2459	T2456	nummod	1999,Huang
R5680	T19169	T19173	amod	loaded,beads
R5681	T19170	T19168	punct	-,NT
R5682	T19171	T19168	nummod	3,NT
R5683	T19172	T19169	punct	-,loaded
R5684	T19173	T19189	nsubjpass	beads,prepared
R5685	T19174	T19175	punct	(,15
R5686	T19175	T19169	parataxis	15,loaded
R5687	T19176	T19175	nsubj	n,15
R5688	T19177	T19175	punct	=,15
R5689	T19178	T19175	punct	),15
R569	T2460	T2456	punct	),Huang
R5690	T19179	T19169	cc	or,loaded
R5691	T19180	T19181	npadvmod	PBS,loaded
R5692	T19181	T19169	conj	loaded,loaded
R5693	T19182	T19181	punct	-,loaded
R5694	T19183	T19184	punct	(,6
R5695	T19184	T19181	parataxis	6,loaded
R5696	T19185	T19184	nsubj	n,6
R5697	T19186	T19184	punct	=,6
R5698	T19187	T19184	punct	),6
R5699	T19188	T19173	compound	sepharose,beads
R57	T488	T487	prep	in,arrive
R570	T2461	T2449	punct	", ",performed
R5700	T19190	T19189	auxpass	were,prepared
R5701	T19191	T19192	mark	as,described
R5702	T19192	T19189	advcl	described,prepared
R5703	T19193	T19192	advmod	above,described
R5704	T19194	T19189	punct	", ",prepared
R5705	T19195	T19189	cc	and,prepared
R5706	T19196	T19189	conj	placed,prepared
R5707	T19197	T19196	prep	in,placed
R5708	T19198	T19199	det	the,midline
R5709	T19199	T19197	pobj	midline,in
R571	T2462	T2449	advcl	enabling,performed
R5710	T19200	T19196	prep	at,placed
R5711	T19201	T19202	amod	mid-spinal,cord
R5712	T19202	T19203	compound	cord,level
R5713	T19203	T19200	pobj	level,at
R5714	T19204	T19189	punct	.,prepared
R5715	T19206	T19207	nsubjpass	Inserts,placed
R5716	T19208	T19207	auxpass	were,placed
R5717	T19209	T19207	prep	in,placed
R5718	T19210	T19211	nummod	six,well
R5719	T19211	T19213	compound	well,plates
R572	T2463	T2462	dobj	detection,enabling
R5720	T19212	T19211	punct	-,well
R5721	T19213	T19209	pobj	plates,in
R5722	T19214	T19207	prep	with,placed
R5723	T19215	T19216	npadvmod	serum,free
R5724	T19216	T19218	amod	free,medium
R5725	T19217	T19216	punct	-,free
R5726	T19218	T19214	pobj	medium,with
R5727	T19219	T19218	prep	at,medium
R5728	T19220	T19221	det	the,bottom
R5729	T19221	T19219	pobj	bottom,at
R573	T2464	T2463	prep	of,detection
R5730	T19222	T19221	prep	of,bottom
R5731	T19223	T19224	det	the,wells
R5732	T19224	T19222	pobj	wells,of
R5733	T19225	T19207	punct	", ",placed
R5734	T19226	T19207	cc	and,placed
R5735	T19227	T19207	conj	kept,placed
R5736	T19228	T19227	prep	at,kept
R5737	T19229	T19230	nummod	33,°C
R5738	T19230	T19228	pobj	°C,at
R5739	T19231	T19227	prep	for,kept
R574	T2465	T2466	det	both,proteins
R5740	T19232	T19233	nummod	3,d
R5741	T19233	T19231	pobj	d,for
R5742	T19234	T19227	prep	in,kept
R5743	T19235	T19236	det	the,presence
R5744	T19236	T19234	pobj	presence,in
R5745	T19237	T19236	prep	of,presence
R5746	T19238	T19239	nummod	5,%
R5747	T19239	T19240	compound	%,CO2
R5748	T19240	T19237	pobj	CO2,of
R5749	T19241	T19207	punct	.,placed
R575	T2466	T2464	pobj	proteins,of
R5750	T19243	T19244	nsubjpass	Cultures,fixed
R5751	T19245	T19244	auxpass	were,fixed
R5752	T19246	T19244	advmod	then,fixed
R5753	T19247	T19244	prep	with,fixed
R5754	T19248	T19249	nummod	4,%
R5755	T19249	T19250	compound	%,paraformaldehyde
R5756	T19250	T19247	pobj	paraformaldehyde,with
R5757	T19251	T19244	prep	in,fixed
R5758	T19252	T19251	pobj	PBS,in
R5759	T19253	T19244	punct	", ",fixed
R576	T2467	T2462	prep	in,enabling
R5760	T19254	T19244	cc	and,fixed
R5761	T19255	T19256	amod	small,crystals
R5762	T19256	T19257	nsubjpass	crystals,placed
R5763	T19257	T19244	conj	placed,fixed
R5764	T19258	T19256	prep	of,crystals
R5765	T19259	T19258	pobj	DiI,of
R5766	T19260	T19257	auxpass	were,placed
R5767	T19261	T19257	prep	into,placed
R5768	T19262	T19263	det	the,DRGs
R5769	T19263	T19261	pobj	DRGs,into
R577	T2468	T2469	det	the,sample
R5770	T19264	T19257	punct	.,placed
R5771	T19266	T19267	nsubjpass	Samples,incubated
R5772	T19268	T19267	auxpass	were,incubated
R5773	T19269	T19267	prep	in,incubated
R5774	T19270	T19271	det	a,incubator
R5775	T19271	T19269	pobj	incubator,in
R5776	T19272	T19273	nummod	37,°C
R5777	T19273	T19271	compound	°C,incubator
R5778	T19274	T19273	punct	-,°C
R5779	T19275	T19267	punct	", ",incubated
R578	T2469	T2467	pobj	sample,in
R5780	T19276	T19267	advcl	allowing,incubated
R5781	T19277	T19278	det	the,dye
R5782	T19278	T19279	nsubj	dye,diffuse
R5783	T19279	T19276	ccomp	diffuse,allowing
R5784	T19280	T19279	aux	to,diffuse
R5785	T19281	T19267	punct	", ",incubated
R5786	T19282	T19267	cc	and,incubated
R5787	T19283	T19267	conj	photographed,incubated
R5788	T19284	T19283	prep	under,photographed
R5789	T19285	T19286	det	a,microscope
R579	T2470	T2469	amod	same,sample
R5790	T19286	T19284	pobj	microscope,under
R5791	T19287	T19286	nmod	Nikon,microscope
R5792	T19288	T19289	punct	(,Tokyo
R5793	T19289	T19287	parataxis	Tokyo,Nikon
R5794	T19290	T19289	punct	", ",Tokyo
R5795	T19291	T19289	npadvmod	Japan,Tokyo
R5796	T19292	T19289	punct	),Tokyo
R5797	T19293	T19294	amod	inverted,epifluoresence
R5798	T19294	T19286	compound	epifluoresence,microscope
R5799	T19295	T19267	punct	.,incubated
R58	T489	T490	amod	close,proximity
R580	T2471	T2449	punct	.,performed
R581	T2473	T2474	npadvmod	TrkC,positive
R582	T2474	T2476	amod	positive,cells
R583	T2475	T2474	punct	-,positive
R584	T2476	T2477	nsubj	cells,were
R585	T2478	T2479	punct	(,1A
R586	T2479	T2476	parataxis	1A,cells
R587	T2480	T2479	compound	Figure,1A
R588	T2481	T2479	punct	),1A
R589	T2482	T2476	cc	and,cells
R59	T490	T488	pobj	proximity,in
R590	T2483	T2476	conj	fibers,cells
R591	T2484	T2485	punct	(,1E
R592	T2485	T2483	parataxis	1E,fibers
R593	T2486	T2485	compound	Figure,1E
R594	T2487	T2485	punct	),1E
R595	T2488	T2477	acomp	absent,were
R596	T2489	T2477	prep	in,were
R597	T2490	T2491	nmod	NT,KOs
R598	T2491	T2489	pobj	KOs,in
R599	T2492	T2490	punct	-,NT
R6	T433	T424	prep	for,required
R60	T491	T490	prep	to,proximity
R600	T2493	T2490	nummod	3,NT
R601	T2494	T2477	prep	at,were
R602	T2495	T2496	amod	embryonic,day
R603	T2496	T2494	pobj	day,at
R604	T2497	T2496	punct	(,day
R605	T2498	T2496	appos	E,day
R606	T2499	T2496	punct	),day
R607	T2500	T2496	nummod	15,day
R608	T2501	T2477	punct	.,were
R609	T2503	T2504	nummod	Two,subsets
R61	T492	T493	poss	their,targets
R610	T2504	T2505	nsubjpass	subsets,detected
R611	T2506	T2504	prep	of,subsets
R612	T2507	T2508	compound	DRG,cells
R613	T2508	T2506	pobj	cells,of
R614	T2509	T2504	acl	expressing,subsets
R615	T2510	T2511	preconj	either,TrkA
R616	T2511	T2509	dobj	TrkA,expressing
R617	T2512	T2511	cc	or,TrkA
R618	T2513	T2511	conj	TrkC,TrkA
R619	T2514	T2505	auxpass	were,detected
R62	T493	T491	pobj	targets,to
R620	T2515	T2505	prep	in,detected
R621	T2516	T2517	amod	double,KOs
R622	T2517	T2515	pobj	KOs,in
R623	T2518	T2505	punct	", ",detected
R624	T2519	T2505	advcl	similar,detected
R625	T2520	T2519	prep	to,similar
R626	T2521	T2522	amod	wild,type
R627	T2522	T2524	nmod	type,animals
R628	T2523	T2522	punct	-,type
R629	T2524	T2520	pobj	animals,to
R630	T2525	T2522	punct	(,type
R631	T2526	T2522	appos	WT,type
R632	T2527	T2522	punct	),type
R633	T2528	T2522	cc	or,type
R634	T2529	T2530	compound	Bax,KO
R635	T2530	T2522	conj	KO,type
R636	T2531	T2505	punct	.,detected
R637	T2533	T2534	advmod	Surprisingly,expressed
R638	T2535	T2534	punct	", ",expressed
R639	T2536	T2534	prep	at,expressed
R640	T2537	T2538	amod	postnatal,day
R641	T2538	T2536	pobj	day,at
R642	T2539	T2538	punct	(,day
R643	T2540	T2538	appos	P,day
R644	T2541	T2538	punct	),day
R645	T2542	T2538	nummod	0,day
R646	T2543	T2534	punct	", ",expressed
R647	T2544	T2545	det	a,cells
R648	T2545	T2534	nsubj	cells,expressed
R649	T2546	T2545	amod	few,cells
R65	T408	T409	det	A,Role
R650	T2547	T2534	dobj	TrkC,expressed
R651	T2548	T2549	advmod	even,in
R652	T2549	T2534	prep	in,expressed
R653	T2550	T2551	nmod	NT,KO
R654	T2551	T2554	compound	KO,animals
R655	T2552	T2550	punct	-,NT
R656	T2553	T2550	nummod	3,NT
R657	T2554	T2549	pobj	animals,in
R658	T2555	T2554	prep	in,animals
R659	T2556	T2557	det	the,background
R66	T411	T409	compound	Chemoattractant,Role
R660	T2557	T2555	pobj	background,in
R661	T2558	T2557	nmod	Bax,background
R662	T2559	T2558	punct	+,Bax
R663	T2560	T2558	punct	/,Bax
R664	T2561	T2558	punct	+,Bax
R665	T2562	T2557	amod	genetic,background
R666	T2563	T2534	punct	", ",expressed
R667	T2564	T2534	cc	and,expressed
R668	T2565	T2566	det	some,cells
R669	T2566	T2567	nsubj	cells,co-expressed
R67	T412	T409	prep	for,Role
R670	T2567	T2534	conj	co-expressed,expressed
R671	T2568	T2567	dobj	TrkA,co-expressed
R672	T2569	T2568	cc	and,TrkA
R673	T2570	T2568	conj	TrkC,TrkA
R674	T2571	T2567	punct	", ",co-expressed
R675	T2572	T2567	advmod	regardless,co-expressed
R676	T2573	T2572	prep	of,regardless
R677	T2574	T2575	det	the,genotype
R678	T2575	T2573	pobj	genotype,of
R679	T2576	T2577	punct	(,1B
R68	T413	T412	pobj	NT,for
R680	T2577	T2567	parataxis	1B,co-expressed
R681	T2578	T2577	compound	Figure,1B
R682	T2579	T2577	punct	),1B
R683	T2580	T2534	punct	.,expressed
R684	T2582	T2583	prep	In,analyzed
R685	T2584	T2582	pobj	order,In
R686	T2585	T2586	aux	to,quantify
R687	T2586	T2584	acl	quantify,order
R688	T2587	T2588	poss	our,results
R689	T2588	T2586	dobj	results,quantify
R69	T414	T413	punct	-,NT
R690	T2589	T2583	punct	", ",analyzed
R691	T2590	T2583	nsubj	we,analyzed
R692	T2591	T2592	det	the,ratio
R693	T2592	T2583	dobj	ratio,analyzed
R694	T2593	T2592	prep	of,ratio
R695	T2594	T2595	npadvmod	TrkA,immunopositive
R696	T2595	T2598	amod	immunopositive,cells
R697	T2596	T2594	cc	and,TrkA
R698	T2597	T2594	conj	TrkC,TrkA
R699	T2598	T2593	pobj	cells,of
R7	T434	T435	amod	proprioceptive,neuron
R70	T415	T413	nummod	3,NT
R700	T2599	T2598	prep	from,cells
R701	T2600	T2601	nummod	four,DRGs
R702	T2601	T2599	pobj	DRGs,from
R703	T2602	T2601	amod	different,DRGs
R704	T2603	T2601	prep	of,DRGs
R705	T2604	T2603	pobj	animals,of
R706	T2605	T2604	prep	of,animals
R707	T2606	T2607	amod	different,genotypes
R708	T2607	T2605	pobj	genotypes,of
R709	T2608	T2583	punct	.,analyzed
R71	T416	T409	prep	in,Role
R710	T2610	T2611	prep	At,had
R711	T2612	T2613	det	all,ages
R712	T2613	T2610	pobj	ages,At
R713	T2614	T2613	acl	studied,ages
R714	T2615	T2611	punct	", ",had
R715	T2616	T2617	npadvmod	Bax,null
R716	T2617	T2623	amod	null,DRGs
R717	T2618	T2616	punct	/,Bax
R718	T2619	T2616	appos	NT,Bax
R719	T2620	T2619	punct	-,NT
R72	T417	T418	compound	Proprioceptive,Axon
R720	T2621	T2619	nummod	3,NT
R721	T2622	T2617	amod	double,null
R722	T2623	T2611	nsubj	DRGs,had
R723	T2624	T2625	compound	TrkA,TrkC
R724	T2625	T2627	compound	TrkC,ratios
R725	T2626	T2625	punct	/,TrkC
R726	T2627	T2611	dobj	ratios,had
R727	T2628	T2627	amod	similar,ratios
R728	T2629	T2628	prep	to,similar
R729	T2630	T2629	pobj	those,to
R73	T418	T419	compound	Axon,Guidance
R730	T2631	T2630	prep	of,those
R731	T2632	T2633	npadvmod	Bax,null
R732	T2633	T2634	amod	null,DRGs
R733	T2634	T2631	pobj	DRGs,of
R734	T2635	T2628	punct	", ",similar
R735	T2636	T2628	cc	and,similar
R736	T2637	T2628	conj	higher,similar
R737	T2638	T2637	prep	than,higher
R738	T2639	T2638	pobj	those,than
R739	T2640	T2639	prep	of,those
R74	T419	T416	pobj	Guidance,in
R740	T2641	T2642	npadvmod	NT,null
R741	T2642	T2645	amod	null,DRGs
R742	T2643	T2641	punct	-,NT
R743	T2644	T2641	nummod	3,NT
R744	T2645	T2640	pobj	DRGs,of
R745	T2646	T2647	punct	(,1D
R746	T2647	T2611	parataxis	1D,had
R747	T2648	T2647	compound	Figure,1D
R748	T2649	T2647	punct	),1D
R749	T2650	T2611	punct	.,had
R75	T423	T424	nsubjpass	"NT-3 and Proprioceptive Axon Guidance Abstract Neurotrophin",required
R750	T2652	T2653	npadvmod	TrkC,positive
R751	T2653	T2655	amod	positive,neurons
R752	T2654	T2653	punct	-,positive
R753	T2655	T2656	nsubj	neurons,failed
R754	T2657	T2655	acl	rescued,neurons
R755	T2658	T2657	prep	by,rescued
R756	T2659	T2660	compound	Bax,deletion
R757	T2660	T2658	pobj	deletion,by
R758	T2661	T2656	punct	", ",failed
R759	T2662	T2656	advmod	however,failed
R76	T425	T423	punct	-,"NT-3 and Proprioceptive Axon Guidance Abstract Neurotrophin"
R760	T2663	T2656	punct	", ",failed
R761	T2664	T2665	aux	to,differentiate
R762	T2665	T2656	xcomp	differentiate,failed
R763	T2666	T2665	advmod	properly,differentiate
R764	T2667	T2665	punct	", ",differentiate
R765	T2668	T2669	mark	as,evidenced
R766	T2669	T2665	advcl	evidenced,differentiate
R767	T2670	T2669	prep	by,evidenced
R768	T2671	T2672	det	the,lack
R769	T2672	T2670	pobj	lack,by
R77	T426	T423	nummod	3,"NT-3 and Proprioceptive Axon Guidance Abstract Neurotrophin"
R770	T2673	T2672	prep	of,lack
R771	T2674	T2673	pobj	expression,of
R772	T2675	T2674	prep	of,expression
R773	T2676	T2677	det	the,marker
R774	T2677	T2675	pobj	marker,of
R775	T2678	T2677	amod	proprioceptive,marker
R776	T2679	T2677	amod	molecular,marker
R777	T2680	T2677	appos	Parvalbumin,marker
R778	T2681	T2677	punct	(,marker
R779	T2682	T2677	appos	PV,marker
R78	T427	T423	punct	(,"NT-3 and Proprioceptive Axon Guidance Abstract Neurotrophin"
R780	T2683	T2656	punct	),failed
R781	T2684	T2685	punct	(,1C
R782	T2685	T2656	parataxis	1C,failed
R783	T2686	T2685	compound	Figure,1C
R784	T2687	T2685	punct	),1C
R785	T2688	T2656	punct	.,failed
R79	T494	T479	cc	but,follow
R790	T3969	T3970	nsubj	NT,Is
R791	T3971	T3969	punct	-,NT
R792	T3972	T3969	nummod	3,NT
R793	T3973	T3970	acomp	Necessary,Is
R794	T3974	T3973	prep	for,Necessary
R795	T3975	T3976	amod	Proper,Innervation
R796	T3976	T3974	pobj	Innervation,for
R797	T3977	T3976	prep	of,Innervation
R798	T3978	T3979	amod	Motor,Neurons
R799	T3979	T3977	pobj	Neurons,of
R8	T435	T436	compound	neuron,survival
R80	T495	T479	conj	fail,follow
R800	T3981	T3982	compound	TrkA,TrkC
R801	T3982	T3984	npadvmod	TrkC,positive
R802	T3983	T3982	punct	/,TrkC
R803	T3984	T3986	amod	positive,fibers
R804	T3985	T3984	punct	-,positive
R805	T3986	T3987	nsubjpass	fibers,detected
R806	T3988	T3986	prep	in,fibers
R807	T3989	T3990	det	the,cord
R808	T3990	T3988	pobj	cord,in
R809	T3991	T3990	amod	spinal,cord
R81	T496	T497	aux	to,innervate
R810	T3992	T3987	aux	could,detected
R811	T3993	T3987	auxpass	be,detected
R812	T3994	T3987	prep	at,detected
R813	T3995	T3994	pobj	E15,at
R814	T3996	T3997	punct	(,1E
R815	T3997	T3987	parataxis	1E,detected
R816	T3998	T3997	compound	Figure,1E
R817	T3999	T3997	punct	),1E
R818	T4000	T3987	punct	.,detected
R819	T4002	T4003	npadvmod	TrkA,positive
R82	T497	T495	xcomp	innervate,fail
R820	T4003	T4005	amod	positive,fibers
R821	T4004	T4003	punct	-,positive
R822	T4005	T4006	nsubj	fibers,restricted
R823	T4007	T4006	aux	were,restricted
R824	T4008	T4006	prep	to,restricted
R825	T4009	T4006	cc	and,restricted
R826	T4010	T4006	conj	terminated,restricted
R827	T4011	T4010	prep	in,terminated
R828	T4012	T4013	det	the,cord
R829	T4013	T4010	dobj	cord,terminated
R83	T498	T497	dobj	them,innervate
R830	T4014	T4013	amod	dorsolateral,cord
R831	T4015	T4013	amod	spinal,cord
R832	T4016	T4006	punct	", ",restricted
R833	T4017	T4018	mark	whereas,entered
R834	T4018	T4006	advcl	entered,restricted
R835	T4019	T4020	npadvmod	TrkC,positive
R836	T4020	T4022	amod	positive,fibers
R837	T4021	T4020	punct	-,positive
R838	T4022	T4018	nsubj	fibers,entered
R839	T4023	T4024	det	the,cord
R84	T499	T479	punct	.,follow
R840	T4024	T4018	dobj	cord,entered
R841	T4025	T4018	advmod	dorsomedially,entered
R842	T4026	T4018	punct	", ",entered
R843	T4027	T4018	cc	and,entered
R844	T4028	T4018	conj	descended,entered
R845	T4029	T4028	prep	into,descended
R846	T4030	T4031	det	the,horns
R847	T4031	T4029	pobj	horns,into
R848	T4032	T4031	amod	ventral,horns
R849	T4033	T4031	prep	in,horns
R85	T501	T502	advmod	Peripherally,are
R850	T4034	T4035	nmod	WT,embryos
R851	T4035	T4033	pobj	embryos,in
R852	T4036	T4037	punct	(,Ozaki
R853	T4037	T4034	meta	Ozaki,WT
R854	T4038	T4037	cc	and,Ozaki
R855	T4039	T4037	conj	Snider,Ozaki
R856	T4040	T4039	nummod	1997,Snider
R857	T4041	T4039	punct	),Snider
R858	T4042	T4034	cc	and,WT
R859	T4043	T4044	compound	Bax,KO
R86	T503	T502	punct	", ",are
R860	T4044	T4034	conj	KO,WT
R861	T4045	T4006	punct	.,restricted
R862	T4047	T4048	expl	There,was
R863	T4049	T4050	det	no,expression
R864	T4050	T4048	attr	expression,was
R865	T4051	T4050	amod	detectable,expression
R866	T4052	T4050	compound	TrkC,expression
R867	T4053	T4048	prep	in,was
R868	T4054	T4055	nmod	NT,KO
R869	T4055	T4058	nmod	KO,cord
R87	T504	T505	compound	muscle,spindles
R870	T4056	T4054	punct	-,NT
R871	T4057	T4054	nummod	3,NT
R872	T4058	T4053	pobj	cord,in
R873	T4059	T4058	amod	spinal,cord
R874	T4060	T4048	punct	", ",was
R875	T4061	T4048	advcl	indicating,was
R876	T4062	T4063	amod	complete,absence
R877	T4063	T4061	dobj	absence,indicating
R878	T4064	T4063	prep	of,absence
R879	T4065	T4066	amod	proprioceptive,fibers
R88	T505	T502	nsubj	spindles,are
R880	T4066	T4064	pobj	fibers,of
R881	T4067	T4048	punct	.,was
R882	T4069	T4070	prep	In,entered
R883	T4071	T4072	amod	double,KO
R884	T4072	T4073	nmod	KO,cord
R885	T4073	T4069	pobj	cord,In
R886	T4074	T4073	amod	spinal,cord
R887	T4075	T4070	punct	", ",entered
R888	T4076	T4077	npadvmod	TrkC,positive
R889	T4077	T4079	amod	positive,fibers
R89	T506	T502	acomp	absent,are
R890	T4078	T4077	punct	-,positive
R891	T4079	T4070	nsubj	fibers,entered
R892	T4080	T4081	det	the,cord
R893	T4081	T4070	dobj	cord,entered
R894	T4082	T4081	amod	dorsal,cord
R895	T4083	T4081	amod	spinal,cord
R896	T4084	T4070	cc	and,entered
R897	T4085	T4070	conj	descended,entered
R898	T4086	T4085	advmod	medially,descended
R899	T4087	T4085	prep	in,descended
R9	T436	T433	pobj	survival,for
R90	T507	T502	cc	and,are
R900	T4088	T4089	det	a,manner
R901	T4089	T4087	pobj	manner,in
R902	T4090	T4089	amod	similar,manner
R903	T4091	T4090	prep	to,similar
R904	T4092	T4091	pobj	that,to
R905	T4093	T4092	acl	seen,that
R906	T4094	T4093	prep	in,seen
R907	T4095	T4096	nmod	WT,cases
R908	T4096	T4094	pobj	cases,in
R909	T4097	T4095	cc	or,WT
R91	T508	T509	npadvmod	TrkC,positive
R910	T4098	T4099	compound	Bax,KO
R911	T4099	T4095	conj	KO,WT
R912	T4100	T4070	punct	.,entered
R913	T4102	T4103	advmod	However,was
R914	T4104	T4103	punct	", ",was
R915	T4105	T4103	nsubj	it,was
R916	T4106	T4103	neg	not,was
R917	T4107	T4103	acomp	possible,was
R918	T4108	T4109	aux	to,follow
R919	T4109	T4103	xcomp	follow,was
R92	T509	T511	amod	positive,axons
R920	T4110	T4111	nmod	TrkC,fibers
R921	T4111	T4109	dobj	fibers,follow
R922	T4112	T4111	amod	immunolabeled,fibers
R923	T4113	T4114	predet	all,way
R924	T4114	T4116	npadvmod	way,to
R925	T4115	T4114	det	the,way
R926	T4116	T4109	prep	to,follow
R927	T4117	T4118	poss	their,zones
R928	T4118	T4116	pobj	zones,to
R929	T4119	T4118	amod	terminal,zones
R93	T510	T509	punct	-,positive
R930	T4120	T4109	prep	in,follow
R931	T4121	T4120	pobj	any,in
R932	T4122	T4121	prep	of,any
R933	T4123	T4124	det	the,cases
R934	T4124	T4122	pobj	cases,of
R935	T4125	T4103	punct	.,was
R936	T4127	T4128	advmod	Next,examined
R937	T4129	T4128	nsubj	we,examined
R938	T4130	T4131	det	the,projections
R939	T4131	T4128	dobj	projections,examined
R94	T511	T512	nsubj	axons,enter
R940	T4132	T4131	amod	central,projections
R941	T4133	T4131	prep	of,projections
R942	T4134	T4135	compound	DRG,axons
R943	T4135	T4133	pobj	axons,of
R944	T4136	T4128	prep	with,examined
R945	T4137	T4138	det	the,tracer
R946	T4138	T4136	pobj	tracer,with
R947	T4139	T4138	amod	lipophilic,tracer
R948	T4140	T4138	appos	DiI,tracer
R949	T4141	T4128	prep	at,examined
R95	T512	T502	conj	enter,are
R950	T4142	T4141	pobj	P0,at
R951	T4143	T4128	punct	.,examined
R952	T4145	T4146	prep	In,entered
R953	T4147	T4148	nmod	WT,pups
R954	T4148	T4145	pobj	pups,In
R955	T4149	T4147	cc	and,WT
R956	T4150	T4151	compound	Bax,KO
R957	T4151	T4147	conj	KO,WT
R958	T4152	T4146	punct	", ",entered
R959	T4153	T4154	amod	proprioceptive,afferents
R96	T513	T512	aux	do,enter
R960	T4154	T4146	nsubj	afferents,entered
R961	T4155	T4156	det	the,cord
R962	T4156	T4146	dobj	cord,entered
R963	T4157	T4156	amod	dorsal,cord
R964	T4158	T4156	amod	spinal,cord
R965	T4159	T4146	cc	and,entered
R966	T4160	T4146	conj	followed,entered
R967	T4161	T4162	det	a,course
R968	T4162	T4160	dobj	course,followed
R969	T4163	T4162	amod	medial,course
R97	T514	T512	neg	not,enter
R970	T4164	T4162	prep	towards,course
R971	T4165	T4166	det	the,horn
R972	T4166	T4164	pobj	horn,towards
R973	T4167	T4166	amod	ventral,horn
R974	T4168	T4146	punct	.,entered
R975	T4170	T4171	nsubj	They,turned
R976	T4172	T4171	advmod	then,turned
R977	T4173	T4171	advmod	laterally,turned
R978	T4174	T4171	prep	towards,turned
R979	T4175	T4176	compound	motor,neurons
R98	T515	T516	poss	their,muscles
R980	T4176	T4174	pobj	neurons,towards
R981	T4177	T4176	prep	in,neurons
R982	T4178	T4179	det	the,column
R983	T4179	T4177	pobj	column,in
R984	T4180	T4179	amod	lateral,column
R985	T4181	T4179	compound	motor,column
R986	T4182	T4179	punct	", ",column
R987	T4183	T4184	advmod	where,branched
R988	T4184	T4179	relcl	branched,column
R989	T4185	T4184	nsubj	they,branched
R99	T516	T512	dobj	muscles,enter
R990	T4186	T4184	cc	and,branched
R991	T4187	T4184	conj	terminated,branched
R992	T4188	T4189	punct	(,2A
R993	T4189	T4171	parataxis	2A,turned
R994	T4190	T4189	compound	Figure,2A
R995	T4191	T4189	punct	),2A
R996	T4192	T4171	punct	.,turned
R997	T4194	T4195	compound	DiI,labeling
R998	T4195	T4196	nsubjpass	labeling,confined
R999	T4197	T4196	auxpass	was,confined

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PMC:529315 JSON TXT 8 Projects