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PMC:523229 / 8551-10186 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T2694 0-2 TO denotes To
T2695 3-11 VB denotes generate
T2697 12-13 DT denotes a
T2699 14-21 JJ denotes general
T2698 22-28 NN denotes system
T2700 29-36 JJ denotes capable
T2701 37-39 IN denotes of
T2702 40-52 RB denotes specifically
T2703 53-60 VBG denotes testing
T2704 61-66 NNS denotes genes
T2705 67-70 IN denotes for
T2706 71-80 NNS denotes functions
T2707 81-83 IN denotes in
T2708 84-92 JJ denotes skeletal
T2710 93-98 NN denotes joint
T2709 99-110 NN denotes development
T2711 110-112 , denotes ,
T2712 112-114 PRP denotes we
T2696 115-125 VBD denotes engineered
T2713 126-136 JJ denotes transgenic
T2714 137-141 NNS denotes mice
T2715 142-144 TO denotes to
T2716 145-152 VB denotes express
T2717 153-156 NN denotes Cre
T2718 157-168 NN denotes recombinase
T2719 169-171 IN denotes in
T2720 172-182 VBG denotes developing
T2721 183-189 NNS denotes joints
T2722 190-191 -LRB- denotes (
T2723 191-197 NN denotes Figure
T2724 198-199 CD denotes 1
T2725 199-200 -RRB- denotes )
T2726 200-201 . denotes .
T2727 201-316 sentence denotes Gdf5 is a gene strongly expressed in stripes across developing skeletal elements during embryonic joint formation.
T2728 202-206 NN denotes Gdf5
T2729 207-209 VBZ denotes is
T2730 210-211 DT denotes a
T2731 212-216 NN denotes gene
T2732 217-225 RB denotes strongly
T2733 226-235 VBN denotes expressed
T2734 236-238 IN denotes in
T2735 239-246 NNS denotes stripes
T2736 247-253 IN denotes across
T2737 254-264 VBG denotes developing
T2739 265-273 JJ denotes skeletal
T2738 274-282 NNS denotes elements
T2740 283-289 IN denotes during
T2741 290-299 JJ denotes embryonic
T2743 300-305 NN denotes joint
T2742 306-315 NN denotes formation
T2744 315-316 . denotes .
T2745 316-603 sentence denotes A bacterial artificial chromosome (BAC) containing the Gdf5 locus was modified by homologous recombination in bacteria to insert a cassette encoding Cre-internal ribosome entry site (IRES)-human placental alkaline phosphatase (hPLAP) into the translation start site of Gdf5 (Figure 1A).
T2746 317-318 DT denotes A
T2748 319-328 JJ denotes bacterial
T2749 329-339 JJ denotes artificial
T2747 340-350 NN denotes chromosome
T2751 351-352 -LRB- denotes (
T2752 352-355 NN denotes BAC
T2753 355-356 -RRB- denotes )
T2754 357-367 VBG denotes containing
T2755 368-371 DT denotes the
T2757 372-376 NN denotes Gdf5
T2756 377-382 NN denotes locus
T2758 383-386 VBD denotes was
T2750 387-395 VBN denotes modified
T2759 396-398 IN denotes by
T2760 399-409 JJ denotes homologous
T2761 410-423 NN denotes recombination
T2762 424-426 IN denotes in
T2763 427-435 NNS denotes bacteria
T2764 436-438 TO denotes to
T2765 439-445 VB denotes insert
T2766 446-447 DT denotes a
T2767 448-456 NN denotes cassette
T2768 457-465 VBG denotes encoding
T2769 466-469 NN denotes Cre
T2771 469-470 HYPH denotes -
T2772 470-478 JJ denotes internal
T2774 479-487 NN denotes ribosome
T2773 488-493 NN denotes entry
T2775 494-498 NN denotes site
T2776 499-500 -LRB- denotes (
T2777 500-504 NN denotes IRES
T2778 504-505 -RRB- denotes )
T2779 505-506 HYPH denotes -
T2780 506-511 JJ denotes human
T2781 512-521 JJ denotes placental
T2782 522-530 NN denotes alkaline
T2770 531-542 NN denotes phosphatase
T2783 543-544 -LRB- denotes (
T2784 544-549 NN denotes hPLAP
T2785 549-550 -RRB- denotes )
T2786 551-555 IN denotes into
T2787 556-559 DT denotes the
T2789 560-571 NN denotes translation
T2790 572-577 NN denotes start
T2788 578-582 NN denotes site
T2791 583-585 IN denotes of
T2792 586-590 NN denotes Gdf5
T2793 591-592 -LRB- denotes (
T2794 592-598 NN denotes Figure
T2795 599-601 CD denotes 1A
T2796 601-602 -RRB- denotes )
T2797 602-603 . denotes .
T2798 603-669 sentence denotes This modified BAC was then used to make lines of transgenic mice.
T2799 604-608 DT denotes This
T2801 609-617 VBN denotes modified
T2800 618-621 NN denotes BAC
T2803 622-625 VBD denotes was
T2804 626-630 RB denotes then
T2802 631-635 VBN denotes used
T2805 636-638 TO denotes to
T2806 639-643 VB denotes make
T2807 644-649 NNS denotes lines
T2808 650-652 IN denotes of
T2809 653-663 JJ denotes transgenic
T2810 664-668 NNS denotes mice
T2811 668-669 . denotes .
T2812 669-927 sentence denotes The resulting Gdf5-Cre transgenic mice were tested for transgene expression and Cre recombinase activity by crossing them to R26R reporter mice that activate the expression of lacZ after Cre-mediated removal of transcriptional stop sequences (Soriano 1999).
T2813 670-673 DT denotes The
T2815 674-683 VBG denotes resulting
T2816 684-688 NN denotes Gdf5
T2818 688-689 HYPH denotes -
T2817 689-692 NN denotes Cre
T2819 693-703 JJ denotes transgenic
T2814 704-708 NNS denotes mice
T2821 709-713 VBD denotes were
T2820 714-720 VBN denotes tested
T2822 721-724 IN denotes for
T2823 725-734 NN denotes transgene
T2824 735-745 NN denotes expression
T2825 746-749 CC denotes and
T2826 750-753 NN denotes Cre
T2827 754-765 NN denotes recombinase
T2828 766-774 NN denotes activity
T2829 775-777 IN denotes by
T2830 778-786 VBG denotes crossing
T2831 787-791 PRP denotes them
T2832 792-794 IN denotes to
T2833 795-799 NN denotes R26R
T2834 800-808 NN denotes reporter
T2835 809-813 NNS denotes mice
T2836 814-818 WDT denotes that
T2837 819-827 VBP denotes activate
T2838 828-831 DT denotes the
T2839 832-842 NN denotes expression
T2840 843-845 IN denotes of
T2841 846-850 NN denotes lacZ
T2842 851-856 IN denotes after
T2843 857-860 NN denotes Cre
T2845 860-861 HYPH denotes -
T2844 861-869 VBN denotes mediated
T2846 870-877 NN denotes removal
T2847 878-880 IN denotes of
T2848 881-896 JJ denotes transcriptional
T2850 897-901 NN denotes stop
T2849 902-911 NNS denotes sequences
T2851 912-913 -LRB- denotes (
T2852 913-920 NNP denotes Soriano
T2853 921-925 CD denotes 1999
T2854 925-926 -RRB- denotes )
T2855 926-927 . denotes .
T2856 927-1083 sentence denotes The resulting progeny were analyzed both for expression of the transgene by assaying HPLAP activity and for recombination of DNA by assaying LACZ activity.
T2857 928-931 DT denotes The
T2859 932-941 VBG denotes resulting
T2858 942-949 NN denotes progeny
T2861 950-954 VBD denotes were
T2860 955-963 VBN denotes analyzed
T2862 964-968 CC denotes both
T2863 969-972 IN denotes for
T2864 973-983 NN denotes expression
T2865 984-986 IN denotes of
T2866 987-990 DT denotes the
T2867 991-1000 NN denotes transgene
T2868 1001-1003 IN denotes by
T2869 1004-1012 VBG denotes assaying
T2870 1013-1018 NN denotes HPLAP
T2871 1019-1027 NN denotes activity
T2872 1028-1031 CC denotes and
T2873 1032-1035 IN denotes for
T2874 1036-1049 NN denotes recombination
T2875 1050-1052 IN denotes of
T2876 1053-1056 NN denotes DNA
T2877 1057-1059 IN denotes by
T2878 1060-1068 VBG denotes assaying
T2879 1069-1073 NN denotes LACZ
T2880 1074-1082 NN denotes activity
T2881 1082-1083 . denotes .
T2882 1083-1247 sentence denotes The progeny from all three lines showed strong LACZ expression primarily in joints, and in two of three lines HPLAP expression could also be seen in joint regions.
T2883 1084-1087 DT denotes The
T2884 1088-1095 NN denotes progeny
T2886 1096-1100 IN denotes from
T2887 1101-1104 DT denotes all
T2889 1105-1110 CD denotes three
T2888 1111-1116 NNS denotes lines
T2885 1117-1123 VBD denotes showed
T2890 1124-1130 JJ denotes strong
T2892 1131-1135 NN denotes LACZ
T2891 1136-1146 NN denotes expression
T2893 1147-1156 RB denotes primarily
T2894 1157-1159 IN denotes in
T2895 1160-1166 NNS denotes joints
T2896 1166-1168 , denotes ,
T2897 1168-1171 CC denotes and
T2898 1172-1174 IN denotes in
T2900 1175-1178 CD denotes two
T2902 1179-1181 IN denotes of
T2901 1182-1187 CD denotes three
T2903 1188-1193 NNS denotes lines
T2904 1194-1199 NN denotes HPLAP
T2905 1200-1210 NN denotes expression
T2906 1211-1216 MD denotes could
T2907 1217-1221 RB denotes also
T2908 1222-1224 VB denotes be
T2899 1225-1229 VBN denotes seen
T2909 1230-1232 IN denotes in
T2910 1233-1238 NN denotes joint
T2911 1239-1246 NNS denotes regions
T2912 1246-1247 . denotes .
T2913 1247-1485 sentence denotes Interestingly, HPLAP expression in the Gdf5-Cre transgenic GAC(A) line used for all subsequent breeding experiments was seen to precede LACZ expression during successive development of joints in the digits (Figure 1C) (unpublished data).
T2914 1248-1261 RB denotes Interestingly
T2916 1261-1263 , denotes ,
T2917 1263-1268 NN denotes HPLAP
T2918 1269-1279 NN denotes expression
T2919 1280-1282 IN denotes in
T2920 1283-1286 DT denotes the
T2922 1287-1291 NN denotes Gdf5
T2924 1291-1292 HYPH denotes -
T2923 1292-1295 NN denotes Cre
T2925 1296-1306 JJ denotes transgenic
T2926 1307-1310 NN denotes GAC
T2928 1310-1311 -LRB- denotes (
T2927 1311-1312 NN denotes A
T2929 1312-1313 -RRB- denotes )
T2921 1314-1318 NN denotes line
T2930 1319-1323 VBN denotes used
T2931 1324-1327 IN denotes for
T2932 1328-1331 DT denotes all
T2934 1332-1342 JJ denotes subsequent
T2935 1343-1351 NN denotes breeding
T2933 1352-1363 NNS denotes experiments
T2936 1364-1367 VBD denotes was
T2915 1368-1372 VBN denotes seen
T2937 1373-1375 TO denotes to
T2938 1376-1383 VB denotes precede
T2939 1384-1388 NN denotes LACZ
T2940 1389-1399 NN denotes expression
T2941 1400-1406 IN denotes during
T2942 1407-1417 JJ denotes successive
T2943 1418-1429 NN denotes development
T2944 1430-1432 IN denotes of
T2945 1433-1439 NNS denotes joints
T2946 1440-1442 IN denotes in
T2947 1443-1446 DT denotes the
T2948 1447-1453 NNS denotes digits
T2949 1454-1455 -LRB- denotes (
T2950 1455-1461 NN denotes Figure
T2951 1462-1464 CD denotes 1C
T2952 1464-1465 -RRB- denotes )
T2953 1466-1467 -LRB- denotes (
T2955 1467-1478 JJ denotes unpublished
T2954 1479-1483 NNS denotes data
T2956 1483-1484 -RRB- denotes )
T2957 1484-1485 . denotes .
T2958 1485-1635 sentence denotes These experiments clearly demonstrate that the Gdf5-Cre transgene expresses Cre recombinase and causes DNA recombination in developing joint regions.
T2959 1486-1491 DT denotes These
T2960 1492-1503 NNS denotes experiments
T2962 1504-1511 RB denotes clearly
T2961 1512-1523 VBP denotes demonstrate
T2963 1524-1528 IN denotes that
T2965 1529-1532 DT denotes the
T2967 1533-1537 NN denotes Gdf5
T2969 1537-1538 HYPH denotes -
T2968 1538-1541 NN denotes Cre
T2966 1542-1551 NN denotes transgene
T2964 1552-1561 VBZ denotes expresses
T2970 1562-1565 NN denotes Cre
T2971 1566-1577 NN denotes recombinase
T2972 1578-1581 CC denotes and
T2973 1582-1588 VBZ denotes causes
T2974 1589-1592 NN denotes DNA
T2975 1593-1606 NN denotes recombination
T2976 1607-1609 IN denotes in
T2977 1610-1620 VBG denotes developing
T2979 1621-1626 NN denotes joint
T2978 1627-1634 NNS denotes regions
T2980 1634-1635 . denotes .
R1437 T2694 T2695 aux To,generate
R1438 T2695 T2696 advcl generate,engineered
R1439 T2697 T2698 det a,system
R1440 T2698 T2695 dobj system,generate
R1441 T2699 T2698 amod general,system
R1442 T2700 T2698 amod capable,system
R1443 T2701 T2700 prep of,capable
R1444 T2702 T2703 advmod specifically,testing
R1445 T2703 T2701 pcomp testing,of
R1446 T2704 T2703 dobj genes,testing
R1447 T2705 T2703 prep for,testing
R1448 T2706 T2705 pobj functions,for
R1449 T2707 T2706 prep in,functions
R1450 T2708 T2709 amod skeletal,development
R1451 T2709 T2707 pobj development,in
R1452 T2710 T2709 compound joint,development
R1453 T2711 T2696 punct ", ",engineered
R1454 T2712 T2696 nsubj we,engineered
R1455 T2713 T2714 amod transgenic,mice
R1456 T2714 T2696 dobj mice,engineered
R1457 T2715 T2716 aux to,express
R1458 T2716 T2696 xcomp express,engineered
R1459 T2717 T2718 compound Cre,recombinase
R1460 T2718 T2716 dobj recombinase,express
R1461 T2719 T2716 prep in,express
R1462 T2720 T2721 amod developing,joints
R1463 T2721 T2719 pobj joints,in
R1464 T2722 T2723 punct (,Figure
R1465 T2723 T2696 parataxis Figure,engineered
R1466 T2724 T2723 nummod 1,Figure
R1467 T2725 T2723 punct ),Figure
R1468 T2726 T2696 punct .,engineered
R1469 T2728 T2729 nsubj Gdf5,is
R1470 T2730 T2731 det a,gene
R1471 T2731 T2729 attr gene,is
R1472 T2732 T2733 advmod strongly,expressed
R1473 T2733 T2731 acl expressed,gene
R1474 T2734 T2733 prep in,expressed
R1475 T2735 T2734 pobj stripes,in
R1476 T2736 T2733 prep across,expressed
R1477 T2737 T2738 amod developing,elements
R1478 T2738 T2736 pobj elements,across
R1479 T2739 T2738 amod skeletal,elements
R1480 T2740 T2733 prep during,expressed
R1481 T2741 T2742 amod embryonic,formation
R1482 T2742 T2740 pobj formation,during
R1483 T2743 T2742 compound joint,formation
R1484 T2744 T2729 punct .,is
R1485 T2746 T2747 det A,chromosome
R1486 T2747 T2750 nsubjpass chromosome,modified
R1487 T2748 T2749 amod bacterial,artificial
R1488 T2749 T2747 amod artificial,chromosome
R1489 T2751 T2747 punct (,chromosome
R1490 T2752 T2747 appos BAC,chromosome
R1491 T2753 T2747 punct ),chromosome
R1492 T2754 T2747 acl containing,chromosome
R1493 T2755 T2756 det the,locus
R1494 T2756 T2754 dobj locus,containing
R1495 T2757 T2756 compound Gdf5,locus
R1496 T2758 T2750 auxpass was,modified
R1497 T2759 T2750 prep by,modified
R1498 T2760 T2761 amod homologous,recombination
R1499 T2761 T2759 pobj recombination,by
R1500 T2762 T2750 prep in,modified
R1501 T2763 T2762 pobj bacteria,in
R1502 T2764 T2765 aux to,insert
R1503 T2765 T2750 advcl insert,modified
R1504 T2766 T2767 det a,cassette
R1505 T2767 T2765 dobj cassette,insert
R1506 T2768 T2767 acl encoding,cassette
R1507 T2769 T2770 nmod Cre,phosphatase
R1508 T2770 T2768 dobj phosphatase,encoding
R1509 T2771 T2770 punct -,phosphatase
R1510 T2772 T2773 amod internal,entry
R1511 T2773 T2775 nmod entry,site
R1512 T2774 T2773 nmod ribosome,entry
R1513 T2775 T2770 nmod site,phosphatase
R1514 T2776 T2775 punct (,site
R1515 T2777 T2775 appos IRES,site
R1516 T2778 T2775 punct ),site
R1517 T2779 T2770 punct -,phosphatase
R1518 T2780 T2781 amod human,placental
R1519 T2781 T2770 amod placental,phosphatase
R1520 T2782 T2770 compound alkaline,phosphatase
R1521 T2783 T2770 punct (,phosphatase
R1522 T2784 T2770 appos hPLAP,phosphatase
R1523 T2785 T2770 punct ),phosphatase
R1524 T2786 T2765 prep into,insert
R1525 T2787 T2788 det the,site
R1526 T2788 T2786 pobj site,into
R1527 T2789 T2788 compound translation,site
R1528 T2790 T2788 compound start,site
R1529 T2791 T2788 prep of,site
R1530 T2792 T2791 pobj Gdf5,of
R1531 T2793 T2794 punct (,Figure
R1532 T2794 T2765 parataxis Figure,insert
R1533 T2795 T2794 nummod 1A,Figure
R1534 T2796 T2794 punct ),Figure
R1535 T2797 T2750 punct .,modified
R1536 T2799 T2800 det This,BAC
R1537 T2800 T2802 nsubjpass BAC,used
R1538 T2801 T2800 amod modified,BAC
R1539 T2803 T2802 auxpass was,used
R1540 T2804 T2802 advmod then,used
R1541 T2805 T2806 aux to,make
R1542 T2806 T2802 advcl make,used
R1543 T2807 T2806 dobj lines,make
R1544 T2808 T2807 prep of,lines
R1545 T2809 T2810 amod transgenic,mice
R1546 T2810 T2808 pobj mice,of
R1547 T2811 T2802 punct .,used
R1548 T2813 T2814 det The,mice
R1549 T2814 T2820 nsubjpass mice,tested
R1550 T2815 T2814 amod resulting,mice
R1551 T2816 T2817 nmod Gdf5,Cre
R1552 T2817 T2814 nmod Cre,mice
R1553 T2818 T2817 punct -,Cre
R1554 T2819 T2814 amod transgenic,mice
R1555 T2821 T2820 auxpass were,tested
R1556 T2822 T2820 prep for,tested
R1557 T2823 T2824 compound transgene,expression
R1558 T2824 T2822 pobj expression,for
R1559 T2825 T2824 cc and,expression
R1560 T2826 T2827 compound Cre,recombinase
R1561 T2827 T2828 compound recombinase,activity
R1562 T2828 T2824 conj activity,expression
R1563 T2829 T2820 prep by,tested
R1564 T2830 T2829 pcomp crossing,by
R1565 T2831 T2830 dobj them,crossing
R1566 T2832 T2830 prep to,crossing
R1567 T2833 T2834 compound R26R,reporter
R1568 T2834 T2835 compound reporter,mice
R1569 T2835 T2832 pobj mice,to
R1570 T2836 T2837 dep that,activate
R1571 T2837 T2835 relcl activate,mice
R1572 T2838 T2839 det the,expression
R1573 T2839 T2837 dobj expression,activate
R1574 T2840 T2839 prep of,expression
R1575 T2841 T2840 pobj lacZ,of
R1576 T2842 T2837 prep after,activate
R1577 T2843 T2844 npadvmod Cre,mediated
R1578 T2844 T2846 amod mediated,removal
R1579 T2845 T2844 punct -,mediated
R1580 T2846 T2842 pobj removal,after
R1581 T2847 T2846 prep of,removal
R1582 T2848 T2849 amod transcriptional,sequences
R1583 T2849 T2847 pobj sequences,of
R1584 T2850 T2849 compound stop,sequences
R1585 T2851 T2852 punct (,Soriano
R1586 T2852 T2820 meta Soriano,tested
R1587 T2853 T2852 nummod 1999,Soriano
R1588 T2854 T2852 punct ),Soriano
R1589 T2855 T2820 punct .,tested
R1590 T2857 T2858 det The,progeny
R1591 T2858 T2860 nsubjpass progeny,analyzed
R1592 T2859 T2858 amod resulting,progeny
R1593 T2861 T2860 auxpass were,analyzed
R1594 T2862 T2860 preconj both,analyzed
R1595 T2863 T2860 conj for,analyzed
R1596 T2864 T2863 pobj expression,for
R1597 T2865 T2864 prep of,expression
R1598 T2866 T2867 det the,transgene
R1599 T2867 T2865 pobj transgene,of
R1600 T2868 T2863 prep by,for
R1601 T2869 T2868 pcomp assaying,by
R1602 T2870 T2871 compound HPLAP,activity
R1603 T2871 T2869 dobj activity,assaying
R1604 T2872 T2860 cc and,analyzed
R1605 T2873 T2860 conj for,analyzed
R1606 T2874 T2873 pobj recombination,for
R1607 T2875 T2874 prep of,recombination
R1608 T2876 T2875 pobj DNA,of
R1609 T2877 T2873 prep by,for
R1610 T2878 T2877 pcomp assaying,by
R1611 T2879 T2880 compound LACZ,activity
R1612 T2880 T2878 dobj activity,assaying
R1613 T2881 T2860 punct .,analyzed
R1614 T2883 T2884 det The,progeny
R1615 T2884 T2885 nsubj progeny,showed
R1616 T2886 T2884 prep from,progeny
R1617 T2887 T2888 det all,lines
R1618 T2888 T2886 pobj lines,from
R1619 T2889 T2888 nummod three,lines
R1620 T2890 T2891 amod strong,expression
R1621 T2891 T2885 dobj expression,showed
R1622 T2892 T2891 compound LACZ,expression
R1623 T2893 T2894 advmod primarily,in
R1624 T2894 T2885 prep in,showed
R1625 T2895 T2894 pobj joints,in
R1626 T2896 T2885 punct ", ",showed
R1627 T2897 T2885 cc and,showed
R1628 T2898 T2899 prep in,seen
R1629 T2899 T2885 conj seen,showed
R1630 T2900 T2901 quantmod two,three
R1631 T2901 T2903 nummod three,lines
R1632 T2902 T2901 quantmod of,three
R1633 T2903 T2898 pobj lines,in
R1634 T2904 T2905 compound HPLAP,expression
R1635 T2905 T2899 nsubjpass expression,seen
R1636 T2906 T2899 aux could,seen
R1637 T2907 T2899 advmod also,seen
R1638 T2908 T2899 auxpass be,seen
R1639 T2909 T2899 prep in,seen
R1640 T2910 T2911 compound joint,regions
R1641 T2911 T2909 pobj regions,in
R1642 T2912 T2899 punct .,seen
R1643 T2914 T2915 advmod Interestingly,seen
R1644 T2916 T2915 punct ", ",seen
R1645 T2917 T2918 compound HPLAP,expression
R1646 T2918 T2915 nsubjpass expression,seen
R1647 T2919 T2918 prep in,expression
R1648 T2920 T2921 det the,line
R1649 T2921 T2919 pobj line,in
R1650 T2922 T2923 nmod Gdf5,Cre
R1651 T2923 T2921 nmod Cre,line
R1652 T2924 T2923 punct -,Cre
R1653 T2925 T2923 amod transgenic,Cre
R1654 T2926 T2927 nmod GAC,A
R1655 T2927 T2923 appos A,Cre
R1656 T2928 T2927 punct (,A
R1657 T2929 T2927 punct ),A
R1658 T2930 T2921 acl used,line
R1659 T2931 T2930 prep for,used
R1660 T2932 T2933 det all,experiments
R1661 T2933 T2931 pobj experiments,for
R1662 T2934 T2933 amod subsequent,experiments
R1663 T2935 T2933 compound breeding,experiments
R1664 T2936 T2915 auxpass was,seen
R1665 T2937 T2938 aux to,precede
R1666 T2938 T2915 xcomp precede,seen
R1667 T2939 T2940 compound LACZ,expression
R1668 T2940 T2938 dobj expression,precede
R1669 T2941 T2938 prep during,precede
R1670 T2942 T2943 amod successive,development
R1671 T2943 T2941 pobj development,during
R1672 T2944 T2943 prep of,development
R1673 T2945 T2944 pobj joints,of
R1674 T2946 T2943 prep in,development
R1675 T2947 T2948 det the,digits
R1676 T2948 T2946 pobj digits,in
R1677 T2949 T2950 punct (,Figure
R1678 T2950 T2915 parataxis Figure,seen
R1679 T2951 T2950 nummod 1C,Figure
R1680 T2952 T2950 punct ),Figure
R1681 T2953 T2954 punct (,data
R1682 T2954 T2915 meta data,seen
R1683 T2955 T2954 amod unpublished,data
R1684 T2956 T2954 punct ),data
R1685 T2957 T2915 punct .,seen
R1686 T2959 T2960 det These,experiments
R1687 T2960 T2961 nsubj experiments,demonstrate
R1688 T2962 T2961 advmod clearly,demonstrate
R1689 T2963 T2964 mark that,expresses
R1690 T2964 T2961 ccomp expresses,demonstrate
R1691 T2965 T2966 det the,transgene
R1692 T2966 T2964 nsubj transgene,expresses
R1693 T2967 T2968 compound Gdf5,Cre
R1694 T2968 T2966 compound Cre,transgene
R1695 T2969 T2968 punct -,Cre
R1696 T2970 T2971 compound Cre,recombinase
R1697 T2971 T2964 dobj recombinase,expresses
R1698 T2972 T2964 cc and,expresses
R1699 T2973 T2964 conj causes,expresses
R1700 T2974 T2975 compound DNA,recombination
R1701 T2975 T2973 dobj recombination,causes
R1702 T2976 T2964 prep in,expresses
R1703 T2977 T2978 amod developing,regions
R1704 T2978 T2976 pobj regions,in
R1705 T2979 T2978 compound joint,regions
R1706 T2980 T2961 punct .,demonstrate