Id |
Subject |
Object |
Predicate |
Lexical cue |
T1665 |
0-7 |
NN |
denotes |
binding |
T1666 |
7-9 |
, |
denotes |
, |
T1667 |
9-14 |
DT |
denotes |
these |
T1668 |
15-24 |
NNS |
denotes |
complexes |
T1663 |
25-34 |
VBP |
denotes |
transduce |
T1669 |
35-36 |
DT |
denotes |
a |
T1670 |
37-43 |
NN |
denotes |
signal |
T1671 |
44-46 |
IN |
denotes |
by |
T1672 |
47-62 |
VBG |
denotes |
phosphorylating |
T1673 |
63-70 |
NNS |
denotes |
members |
T1674 |
71-73 |
IN |
denotes |
of |
T1675 |
74-77 |
DT |
denotes |
the |
T1677 |
78-82 |
NN |
denotes |
Smad |
T1676 |
83-89 |
NN |
denotes |
family |
T1678 |
90-92 |
IN |
denotes |
of |
T1679 |
93-106 |
NN |
denotes |
transcription |
T1680 |
107-114 |
NNS |
denotes |
factors |
T1681 |
115-116 |
-LRB- |
denotes |
( |
T1682 |
116-124 |
NNP |
denotes |
Massague |
T1683 |
125-129 |
CD |
denotes |
1996 |
T1684 |
129-130 |
-RRB- |
denotes |
) |
T1685 |
130-131 |
. |
denotes |
. |
T1686 |
131-244 |
sentence |
denotes |
Recent experiments have implicated two different BMP type I receptors in skeletal patterning, BMPR1A and BMPR1B. |
T1687 |
132-138 |
JJ |
denotes |
Recent |
T1688 |
139-150 |
NNS |
denotes |
experiments |
T1690 |
151-155 |
VBP |
denotes |
have |
T1689 |
156-166 |
VBN |
denotes |
implicated |
T1691 |
167-170 |
CD |
denotes |
two |
T1693 |
171-180 |
JJ |
denotes |
different |
T1694 |
181-184 |
NN |
denotes |
BMP |
T1695 |
185-189 |
NN |
denotes |
type |
T1696 |
190-191 |
CD |
denotes |
I |
T1692 |
192-201 |
NNS |
denotes |
receptors |
T1697 |
202-204 |
IN |
denotes |
in |
T1698 |
205-213 |
JJ |
denotes |
skeletal |
T1699 |
214-224 |
NN |
denotes |
patterning |
T1700 |
224-226 |
, |
denotes |
, |
T1701 |
226-232 |
NN |
denotes |
BMPR1A |
T1702 |
233-236 |
CC |
denotes |
and |
T1703 |
237-243 |
NN |
denotes |
BMPR1B |
T1704 |
243-244 |
. |
denotes |
. |
T1705 |
244-445 |
sentence |
denotes |
Both receptors can bind BMP2, BMP4, and GDF5, although GDF5 shows higher affinity for BMPR1B (Koenig et al. 1994; ten Dijke et al. 1994; Yamaji et al. 1994; Nishitoh et al. 1996; Chalaux et al. 1998). |
T1706 |
245-249 |
DT |
denotes |
Both |
T1707 |
250-259 |
NNS |
denotes |
receptors |
T1709 |
260-263 |
MD |
denotes |
can |
T1708 |
264-268 |
VB |
denotes |
bind |
T1710 |
269-273 |
NN |
denotes |
BMP2 |
T1711 |
273-275 |
, |
denotes |
, |
T1712 |
275-279 |
NN |
denotes |
BMP4 |
T1713 |
279-281 |
, |
denotes |
, |
T1714 |
281-284 |
CC |
denotes |
and |
T1715 |
285-289 |
NN |
denotes |
GDF5 |
T1716 |
289-291 |
, |
denotes |
, |
T1717 |
291-299 |
IN |
denotes |
although |
T1719 |
300-304 |
NN |
denotes |
GDF5 |
T1718 |
305-310 |
VBZ |
denotes |
shows |
T1720 |
311-317 |
JJR |
denotes |
higher |
T1721 |
318-326 |
NN |
denotes |
affinity |
T1722 |
327-330 |
IN |
denotes |
for |
T1723 |
331-337 |
NN |
denotes |
BMPR1B |
T1724 |
338-339 |
-LRB- |
denotes |
( |
T1725 |
339-345 |
NNP |
denotes |
Koenig |
T1726 |
346-348 |
FW |
denotes |
et |
T1727 |
349-352 |
FW |
denotes |
al. |
T1728 |
353-357 |
CD |
denotes |
1994 |
T1729 |
357-358 |
: |
denotes |
; |
T1730 |
359-362 |
NNP |
denotes |
ten |
T1731 |
363-368 |
NNP |
denotes |
Dijke |
T1732 |
369-371 |
FW |
denotes |
et |
T1733 |
372-375 |
FW |
denotes |
al. |
T1734 |
376-380 |
CD |
denotes |
1994 |
T1735 |
380-381 |
: |
denotes |
; |
T1736 |
382-388 |
NNP |
denotes |
Yamaji |
T1737 |
389-391 |
FW |
denotes |
et |
T1738 |
392-395 |
FW |
denotes |
al. |
T1739 |
396-400 |
CD |
denotes |
1994 |
T1740 |
400-401 |
: |
denotes |
; |
T1741 |
402-410 |
NNP |
denotes |
Nishitoh |
T1742 |
411-413 |
FW |
denotes |
et |
T1743 |
414-417 |
FW |
denotes |
al. |
T1744 |
418-422 |
CD |
denotes |
1996 |
T1745 |
422-423 |
: |
denotes |
; |
T1746 |
424-431 |
NNP |
denotes |
Chalaux |
T1747 |
432-434 |
FW |
denotes |
et |
T1748 |
435-438 |
FW |
denotes |
al. |
T1749 |
439-443 |
CD |
denotes |
1998 |
T1750 |
443-444 |
-RRB- |
denotes |
) |
T1751 |
444-445 |
. |
denotes |
. |
T1752 |
445-526 |
sentence |
denotes |
Both receptors are also expressed in dynamic patterns during normal development. |
T1753 |
446-450 |
DT |
denotes |
Both |
T1754 |
451-460 |
NNS |
denotes |
receptors |
T1756 |
461-464 |
VBP |
denotes |
are |
T1757 |
465-469 |
RB |
denotes |
also |
T1755 |
470-479 |
VBN |
denotes |
expressed |
T1758 |
480-482 |
IN |
denotes |
in |
T1759 |
483-490 |
JJ |
denotes |
dynamic |
T1760 |
491-499 |
NNS |
denotes |
patterns |
T1761 |
500-506 |
IN |
denotes |
during |
T1762 |
507-513 |
JJ |
denotes |
normal |
T1763 |
514-525 |
NN |
denotes |
development |
T1764 |
525-526 |
. |
denotes |
. |
T1765 |
526-695 |
sentence |
denotes |
In limbs, Bmpr1a expression becomes restricted to joint interzones, perichondrium, periarticular cartilage, hypertrophic chondrocytes, and interdigital limb mesenchyme. |
T1766 |
527-529 |
IN |
denotes |
In |
T1768 |
530-535 |
NNS |
denotes |
limbs |
T1769 |
535-537 |
, |
denotes |
, |
T1770 |
537-543 |
NN |
denotes |
Bmpr1a |
T1771 |
544-554 |
NN |
denotes |
expression |
T1767 |
555-562 |
VBZ |
denotes |
becomes |
T1772 |
563-573 |
JJ |
denotes |
restricted |
T1773 |
574-576 |
IN |
denotes |
to |
T1774 |
577-582 |
NN |
denotes |
joint |
T1775 |
583-593 |
NNS |
denotes |
interzones |
T1776 |
593-595 |
, |
denotes |
, |
T1777 |
595-608 |
NN |
denotes |
perichondrium |
T1778 |
608-610 |
, |
denotes |
, |
T1779 |
610-623 |
JJ |
denotes |
periarticular |
T1780 |
624-633 |
NN |
denotes |
cartilage |
T1781 |
633-635 |
, |
denotes |
, |
T1782 |
635-647 |
JJ |
denotes |
hypertrophic |
T1783 |
648-660 |
NNS |
denotes |
chondrocytes |
T1784 |
660-662 |
, |
denotes |
, |
T1785 |
662-665 |
CC |
denotes |
and |
T1786 |
666-678 |
JJ |
denotes |
interdigital |
T1788 |
679-683 |
NN |
denotes |
limb |
T1787 |
684-694 |
NN |
denotes |
mesenchyme |
T1789 |
694-695 |
. |
denotes |
. |
T1790 |
695-952 |
sentence |
denotes |
In comparison, Bmpr1b expression is seen primarily in condensing precartilaginous mesenchymal cells, regions flanking joint interzones, perichondrium, and periarticular cartilage (Dewulf et al. 1995; Mishina et al. 1995; Zou et al. 1997; Baur et al. 2000). |
T1791 |
696-698 |
IN |
denotes |
In |
T1793 |
699-709 |
NN |
denotes |
comparison |
T1794 |
709-711 |
, |
denotes |
, |
T1795 |
711-717 |
NN |
denotes |
Bmpr1b |
T1796 |
718-728 |
NN |
denotes |
expression |
T1797 |
729-731 |
VBZ |
denotes |
is |
T1792 |
732-736 |
VBN |
denotes |
seen |
T1798 |
737-746 |
RB |
denotes |
primarily |
T1799 |
747-749 |
IN |
denotes |
in |
T1800 |
750-760 |
VBG |
denotes |
condensing |
T1802 |
761-777 |
JJ |
denotes |
precartilaginous |
T1803 |
778-789 |
JJ |
denotes |
mesenchymal |
T1801 |
790-795 |
NNS |
denotes |
cells |
T1804 |
795-797 |
, |
denotes |
, |
T1805 |
797-804 |
NNS |
denotes |
regions |
T1806 |
805-813 |
VBG |
denotes |
flanking |
T1807 |
814-819 |
NN |
denotes |
joint |
T1808 |
820-830 |
NNS |
denotes |
interzones |
T1809 |
830-832 |
, |
denotes |
, |
T1810 |
832-845 |
NN |
denotes |
perichondrium |
T1811 |
845-847 |
, |
denotes |
, |
T1812 |
847-850 |
CC |
denotes |
and |
T1813 |
851-864 |
JJ |
denotes |
periarticular |
T1814 |
865-874 |
NN |
denotes |
cartilage |
T1815 |
875-876 |
-LRB- |
denotes |
( |
T1816 |
876-882 |
NNP |
denotes |
Dewulf |
T1817 |
883-885 |
FW |
denotes |
et |
T1818 |
886-889 |
FW |
denotes |
al. |
T1819 |
890-894 |
CD |
denotes |
1995 |
T1820 |
894-895 |
: |
denotes |
; |
T1821 |
896-903 |
NNP |
denotes |
Mishina |
T1822 |
904-906 |
FW |
denotes |
et |
T1823 |
907-910 |
FW |
denotes |
al. |
T1824 |
911-915 |
CD |
denotes |
1995 |
T1825 |
915-916 |
: |
denotes |
; |
T1826 |
917-920 |
NNP |
denotes |
Zou |
T1827 |
921-923 |
FW |
denotes |
et |
T1828 |
924-927 |
FW |
denotes |
al. |
T1829 |
928-932 |
CD |
denotes |
1997 |
T1830 |
932-933 |
: |
denotes |
; |
T1831 |
934-938 |
NNP |
denotes |
Baur |
T1832 |
939-941 |
FW |
denotes |
et |
T1833 |
942-945 |
FW |
denotes |
al. |
T1834 |
946-950 |
CD |
denotes |
2000 |
T1835 |
950-951 |
-RRB- |
denotes |
) |
T1836 |
951-952 |
. |
denotes |
. |
T1837 |
952-1162 |
sentence |
denotes |
Null mutations in the Bmpr1b gene produce viable mice with defects in bone and joint formation that closely resemble those seen in mice missing Gdf5 (Storm and Kingsley 1996; Baur et al. 2000; Yi et al. 2000). |
T1838 |
953-957 |
JJ |
denotes |
Null |
T1839 |
958-967 |
NNS |
denotes |
mutations |
T1841 |
968-970 |
IN |
denotes |
in |
T1842 |
971-974 |
DT |
denotes |
the |
T1844 |
975-981 |
NN |
denotes |
Bmpr1b |
T1843 |
982-986 |
NN |
denotes |
gene |
T1840 |
987-994 |
VBP |
denotes |
produce |
T1845 |
995-1001 |
JJ |
denotes |
viable |
T1846 |
1002-1006 |
NNS |
denotes |
mice |
T1847 |
1007-1011 |
IN |
denotes |
with |
T1848 |
1012-1019 |
NNS |
denotes |
defects |
T1849 |
1020-1022 |
IN |
denotes |
in |
T1850 |
1023-1027 |
NN |
denotes |
bone |
T1852 |
1028-1031 |
CC |
denotes |
and |
T1853 |
1032-1037 |
NN |
denotes |
joint |
T1851 |
1038-1047 |
NN |
denotes |
formation |
T1854 |
1048-1052 |
WDT |
denotes |
that |
T1856 |
1053-1060 |
RB |
denotes |
closely |
T1855 |
1061-1069 |
VBP |
denotes |
resemble |
T1857 |
1070-1075 |
DT |
denotes |
those |
T1858 |
1076-1080 |
VBN |
denotes |
seen |
T1859 |
1081-1083 |
IN |
denotes |
in |
T1860 |
1084-1088 |
NNS |
denotes |
mice |
T1861 |
1089-1096 |
VBG |
denotes |
missing |
T1862 |
1097-1101 |
NN |
denotes |
Gdf5 |
T1863 |
1102-1103 |
-LRB- |
denotes |
( |
T1864 |
1103-1108 |
NNP |
denotes |
Storm |
T1865 |
1109-1112 |
CC |
denotes |
and |
T1866 |
1113-1121 |
NNP |
denotes |
Kingsley |
T1867 |
1122-1126 |
CD |
denotes |
1996 |
T1868 |
1126-1127 |
: |
denotes |
; |
T1869 |
1128-1132 |
NNP |
denotes |
Baur |
T1870 |
1133-1135 |
FW |
denotes |
et |
T1871 |
1136-1139 |
FW |
denotes |
al. |
T1872 |
1140-1144 |
CD |
denotes |
2000 |
T1873 |
1144-1145 |
: |
denotes |
; |
T1874 |
1146-1148 |
NNP |
denotes |
Yi |
T1875 |
1149-1151 |
FW |
denotes |
et |
T1876 |
1152-1155 |
FW |
denotes |
al. |
T1877 |
1156-1160 |
CD |
denotes |
2000 |
T1878 |
1160-1161 |
-RRB- |
denotes |
) |
T1879 |
1161-1162 |
. |
denotes |
. |
T1880 |
1162-1346 |
sentence |
denotes |
Null mutations in Bmpr1a cause early embryonic lethality, with defects in gastrulation similar to those seen in mice with mutations in Bmp4 (Mishina et al. 1995; Winnier et al. 1995). |
T1881 |
1163-1167 |
JJ |
denotes |
Null |
T1882 |
1168-1177 |
NNS |
denotes |
mutations |
T1884 |
1178-1180 |
IN |
denotes |
in |
T1885 |
1181-1187 |
NN |
denotes |
Bmpr1a |
T1883 |
1188-1193 |
VBP |
denotes |
cause |
T1886 |
1194-1199 |
JJ |
denotes |
early |
T1888 |
1200-1209 |
JJ |
denotes |
embryonic |
T1887 |
1210-1219 |
NN |
denotes |
lethality |
T1889 |
1219-1221 |
, |
denotes |
, |
T1890 |
1221-1225 |
IN |
denotes |
with |
T1892 |
1226-1233 |
NNS |
denotes |
defects |
T1893 |
1234-1236 |
IN |
denotes |
in |
T1894 |
1237-1249 |
NN |
denotes |
gastrulation |
T1891 |
1250-1257 |
JJ |
denotes |
similar |
T1895 |
1258-1260 |
IN |
denotes |
to |
T1896 |
1261-1266 |
DT |
denotes |
those |
T1897 |
1267-1271 |
VBN |
denotes |
seen |
T1898 |
1272-1274 |
IN |
denotes |
in |
T1899 |
1275-1279 |
NNS |
denotes |
mice |
T1900 |
1280-1284 |
IN |
denotes |
with |
T1901 |
1285-1294 |
NNS |
denotes |
mutations |
T1902 |
1295-1297 |
IN |
denotes |
in |
T1903 |
1298-1302 |
NN |
denotes |
Bmp4 |
T1904 |
1303-1304 |
-LRB- |
denotes |
( |
T1905 |
1304-1311 |
NNP |
denotes |
Mishina |
T1906 |
1312-1314 |
FW |
denotes |
et |
T1907 |
1315-1318 |
FW |
denotes |
al. |
T1908 |
1319-1323 |
CD |
denotes |
1995 |
T1909 |
1323-1324 |
: |
denotes |
; |
T1910 |
1325-1332 |
NNP |
denotes |
Winnier |
T1911 |
1333-1335 |
FW |
denotes |
et |
T1912 |
1336-1339 |
FW |
denotes |
al. |
T1913 |
1340-1344 |
CD |
denotes |
1995 |
T1914 |
1344-1345 |
-RRB- |
denotes |
) |
T1915 |
1345-1346 |
. |
denotes |
. |
T1917 |
1347-1353 |
JJ |
denotes |
Recent |
T1918 |
1354-1361 |
NNS |
denotes |
studies |
T1920 |
1362-1366 |
IN |
denotes |
with |
T1921 |
1367-1373 |
VBN |
denotes |
floxed |
T1922 |
1374-1381 |
NNS |
denotes |
alleles |
T1919 |
1382-1389 |
VBP |
denotes |
suggest |
T1923 |
1390-1394 |
IN |
denotes |
that |
T1925 |
1395-1401 |
NN |
denotes |
Bmpr1a |
T1926 |
1402-1404 |
VBZ |
denotes |
is |
T1927 |
1405-1409 |
RB |
denotes |
also |
T1924 |
1410-1418 |
VBN |
denotes |
required |
T1928 |
1419-1422 |
IN |
denotes |
for |
T1929 |
1423-1427 |
JJ |
denotes |
many |
T1931 |
1428-1433 |
JJ |
denotes |
later |
T1932 |
1434-1447 |
JJ |
denotes |
developmental |
T1930 |
1448-1454 |
NNS |
denotes |
events |
T1933 |
1454-1456 |
, |
denotes |
, |
T1934 |
1456-1459 |
CC |
denotes |
but |
T1935 |
1460-1463 |
PRP$ |
denotes |
its |
T1936 |
1464-1469 |
NNS |
denotes |
roles |
T1938 |
1470-1472 |
IN |
denotes |
in |
R1000 |
T1762 |
T1763 |
amod |
normal,development |
R1001 |
T1804 |
T1801 |
punct |
", ",cells |
R1002 |
T1805 |
T1801 |
appos |
regions,cells |
R1003 |
T1763 |
T1761 |
pobj |
development,during |
R1004 |
T1806 |
T1805 |
acl |
flanking,regions |
R1005 |
T1807 |
T1808 |
compound |
joint,interzones |
R1006 |
T1764 |
T1755 |
punct |
.,expressed |
R1007 |
T1808 |
T1806 |
dobj |
interzones,flanking |
R1008 |
T1809 |
T1808 |
punct |
", ",interzones |
R1009 |
T1810 |
T1808 |
conj |
perichondrium,interzones |
R1010 |
T1766 |
T1767 |
prep |
In,becomes |
R1011 |
T1811 |
T1810 |
punct |
", ",perichondrium |
R1012 |
T1812 |
T1810 |
cc |
and,perichondrium |
R1013 |
T1813 |
T1814 |
amod |
periarticular,cartilage |
R1014 |
T1814 |
T1810 |
conj |
cartilage,perichondrium |
R1015 |
T1768 |
T1766 |
pobj |
limbs,In |
R1016 |
T1815 |
T1816 |
punct |
(,Dewulf |
R1017 |
T1816 |
T1792 |
meta |
Dewulf,seen |
R1018 |
T1817 |
T1816 |
nmod |
et,Dewulf |
R1019 |
T1818 |
T1816 |
nmod |
al.,Dewulf |
R1020 |
T1769 |
T1767 |
punct |
", ",becomes |
R1021 |
T1819 |
T1816 |
nummod |
1995,Dewulf |
R1022 |
T1820 |
T1816 |
punct |
;,Dewulf |
R1023 |
T1770 |
T1771 |
compound |
Bmpr1a,expression |
R1024 |
T1821 |
T1816 |
nmod |
Mishina,Dewulf |
R1025 |
T1822 |
T1816 |
nmod |
et,Dewulf |
R1026 |
T1823 |
T1816 |
nmod |
al.,Dewulf |
R1027 |
T1771 |
T1767 |
nsubj |
expression,becomes |
R1028 |
T1824 |
T1816 |
nummod |
1995,Dewulf |
R1029 |
T1825 |
T1816 |
punct |
;,Dewulf |
R1030 |
T1826 |
T1816 |
nmod |
Zou,Dewulf |
R1031 |
T1772 |
T1767 |
oprd |
restricted,becomes |
R1032 |
T1827 |
T1816 |
nmod |
et,Dewulf |
R1033 |
T1828 |
T1816 |
nmod |
al.,Dewulf |
R1034 |
T1829 |
T1816 |
nummod |
1997,Dewulf |
R1035 |
T1830 |
T1816 |
punct |
;,Dewulf |
R1036 |
T1831 |
T1816 |
nmod |
Baur,Dewulf |
R1037 |
T1773 |
T1772 |
prep |
to,restricted |
R1038 |
T1832 |
T1816 |
nmod |
et,Dewulf |
R1039 |
T1833 |
T1816 |
nmod |
al.,Dewulf |
R1040 |
T1834 |
T1816 |
nummod |
2000,Dewulf |
R1041 |
T1774 |
T1775 |
compound |
joint,interzones |
R1042 |
T1835 |
T1816 |
punct |
),Dewulf |
R1043 |
T1836 |
T1792 |
punct |
.,seen |
R1044 |
T1775 |
T1773 |
pobj |
interzones,to |
R1045 |
T1838 |
T1839 |
amod |
Null,mutations |
R1046 |
T1839 |
T1840 |
nsubj |
mutations,produce |
R1047 |
T1776 |
T1775 |
punct |
", ",interzones |
R1048 |
T1841 |
T1839 |
prep |
in,mutations |
R1049 |
T1842 |
T1843 |
det |
the,gene |
R1050 |
T1777 |
T1775 |
conj |
perichondrium,interzones |
R1051 |
T1843 |
T1841 |
pobj |
gene,in |
R1052 |
T1844 |
T1843 |
compound |
Bmpr1b,gene |
R1053 |
T1845 |
T1846 |
amod |
viable,mice |
R1054 |
T1778 |
T1777 |
punct |
", ",perichondrium |
R1055 |
T1846 |
T1840 |
dobj |
mice,produce |
R1056 |
T1847 |
T1846 |
prep |
with,mice |
R1057 |
T1779 |
T1780 |
amod |
periarticular,cartilage |
R1058 |
T1848 |
T1847 |
pobj |
defects,with |
R1059 |
T1849 |
T1848 |
prep |
in,defects |
R1060 |
T1850 |
T1851 |
nmod |
bone,formation |
R1061 |
T1780 |
T1777 |
conj |
cartilage,perichondrium |
R1062 |
T1851 |
T1849 |
pobj |
formation,in |
R1063 |
T1852 |
T1850 |
cc |
and,bone |
R1064 |
T1853 |
T1850 |
conj |
joint,bone |
R1065 |
T1781 |
T1780 |
punct |
", ",cartilage |
R1066 |
T1854 |
T1855 |
dep |
that,resemble |
R1067 |
T1855 |
T1848 |
relcl |
resemble,defects |
R1068 |
T1856 |
T1855 |
advmod |
closely,resemble |
R1069 |
T1782 |
T1783 |
amod |
hypertrophic,chondrocytes |
R1070 |
T1857 |
T1855 |
dobj |
those,resemble |
R1071 |
T1858 |
T1857 |
acl |
seen,those |
R1072 |
T1783 |
T1780 |
conj |
chondrocytes,cartilage |
R1073 |
T1859 |
T1858 |
prep |
in,seen |
R1074 |
T1860 |
T1859 |
pobj |
mice,in |
R1075 |
T1861 |
T1860 |
acl |
missing,mice |
R1076 |
T1784 |
T1783 |
punct |
", ",chondrocytes |
R1077 |
T1862 |
T1861 |
dobj |
Gdf5,missing |
R1078 |
T1863 |
T1864 |
punct |
(,Storm |
R1079 |
T1785 |
T1783 |
cc |
and,chondrocytes |
R1080 |
T1864 |
T1840 |
meta |
Storm,produce |
R1081 |
T1865 |
T1864 |
cc |
and,Storm |
R1082 |
T1866 |
T1864 |
conj |
Kingsley,Storm |
R1083 |
T1786 |
T1787 |
amod |
interdigital,mesenchyme |
R1084 |
T1867 |
T1866 |
nummod |
1996,Kingsley |
R1085 |
T1868 |
T1866 |
punct |
;,Kingsley |
R1086 |
T1869 |
T1866 |
conj |
Baur,Kingsley |
R1087 |
T1870 |
T1869 |
nmod |
et,Baur |
R1088 |
T1871 |
T1869 |
nmod |
al.,Baur |
R1089 |
T1787 |
T1783 |
conj |
mesenchyme,chondrocytes |
R1090 |
T1872 |
T1869 |
nummod |
2000,Baur |
R1091 |
T1873 |
T1869 |
punct |
;,Baur |
R1092 |
T1874 |
T1869 |
conj |
Yi,Baur |
R1093 |
T1788 |
T1787 |
compound |
limb,mesenchyme |
R1094 |
T1875 |
T1874 |
nmod |
et,Yi |
R1095 |
T1789 |
T1767 |
punct |
.,becomes |
R1096 |
T1876 |
T1874 |
nmod |
al.,Yi |
R1097 |
T1877 |
T1874 |
nummod |
2000,Yi |
R1098 |
T1791 |
T1792 |
prep |
In,seen |
R1099 |
T1878 |
T1874 |
punct |
),Yi |
R1100 |
T1879 |
T1840 |
punct |
.,produce |
R1101 |
T1793 |
T1791 |
pobj |
comparison,In |
R1102 |
T1881 |
T1882 |
amod |
Null,mutations |
R1103 |
T1882 |
T1883 |
nsubj |
mutations,cause |
R1104 |
T1884 |
T1882 |
prep |
in,mutations |
R1105 |
T1794 |
T1792 |
punct |
", ",seen |
R1106 |
T1885 |
T1884 |
pobj |
Bmpr1a,in |
R1107 |
T1886 |
T1887 |
amod |
early,lethality |
R1108 |
T1795 |
T1796 |
compound |
Bmpr1b,expression |
R1109 |
T1887 |
T1883 |
dobj |
lethality,cause |
R1110 |
T1888 |
T1887 |
amod |
embryonic,lethality |
R1111 |
T1889 |
T1883 |
punct |
", ",cause |
R1112 |
T1796 |
T1792 |
nsubjpass |
expression,seen |
R1113 |
T1890 |
T1891 |
mark |
with,similar |
R1114 |
T1891 |
T1883 |
advcl |
similar,cause |
R1115 |
T1892 |
T1891 |
nsubj |
defects,similar |
R1116 |
T1797 |
T1792 |
auxpass |
is,seen |
R1117 |
T1893 |
T1892 |
prep |
in,defects |
R1118 |
T1894 |
T1893 |
pobj |
gastrulation,in |
R1119 |
T1895 |
T1891 |
prep |
to,similar |
R1120 |
T1798 |
T1792 |
advmod |
primarily,seen |
R1121 |
T1896 |
T1895 |
pobj |
those,to |
R1122 |
T1897 |
T1896 |
acl |
seen,those |
R1123 |
T1799 |
T1792 |
prep |
in,seen |
R1124 |
T1898 |
T1897 |
prep |
in,seen |
R1125 |
T1899 |
T1898 |
pobj |
mice,in |
R1126 |
T1900 |
T1899 |
prep |
with,mice |
R1127 |
T1800 |
T1801 |
amod |
condensing,cells |
R1128 |
T1901 |
T1900 |
pobj |
mutations,with |
R1129 |
T1902 |
T1901 |
prep |
in,mutations |
R1130 |
T1903 |
T1902 |
pobj |
Bmp4,in |
R1131 |
T1801 |
T1799 |
pobj |
cells,in |
R1132 |
T1904 |
T1905 |
punct |
(,Mishina |
R1133 |
T1905 |
T1883 |
meta |
Mishina,cause |
R1134 |
T1906 |
T1905 |
nmod |
et,Mishina |
R1135 |
T1908 |
T1905 |
nummod |
1995,Mishina |
R1136 |
T1907 |
T1905 |
nmod |
al.,Mishina |
R1137 |
T1909 |
T1905 |
punct |
;,Mishina |
R1138 |
T1910 |
T1905 |
nmod |
Winnier,Mishina |
R1139 |
T1911 |
T1905 |
nmod |
et,Mishina |
R1142 |
T1912 |
T1905 |
nmod |
al.,Mishina |
R1146 |
T1913 |
T1905 |
nummod |
1995,Mishina |
R1149 |
T1914 |
T1905 |
punct |
),Mishina |
R1152 |
T1915 |
T1883 |
punct |
.,cause |
R1154 |
T1917 |
T1918 |
amod |
Recent,studies |
R1158 |
T1918 |
T1919 |
nsubj |
studies,suggest |
R1162 |
T1920 |
T1918 |
prep |
with,studies |
R1168 |
T1921 |
T1922 |
amod |
floxed,alleles |
R1171 |
T1922 |
T1920 |
pobj |
alleles,with |
R1175 |
T1923 |
T1924 |
mark |
that,required |
R1179 |
T1924 |
T1919 |
ccomp |
required,suggest |
R1182 |
T1925 |
T1924 |
nsubjpass |
Bmpr1a,required |
R1184 |
T1926 |
T1924 |
auxpass |
is,required |
R1186 |
T1927 |
T1924 |
advmod |
also,required |
R1191 |
T1928 |
T1924 |
prep |
for,required |
R1192 |
T1929 |
T1930 |
amod |
many,events |
R1195 |
T1930 |
T1928 |
pobj |
events,for |
R1198 |
T1931 |
T1930 |
amod |
later,events |
R1201 |
T1932 |
T1930 |
amod |
developmental,events |
R1205 |
T1933 |
T1919 |
punct |
", ",suggest |
R1208 |
T1934 |
T1919 |
cc |
but,suggest |
R1211 |
T1935 |
T1936 |
poss |
its,roles |
R1221 |
T1938 |
T1936 |
prep |
in,roles |
R908 |
T1666 |
T1663 |
punct |
", ",transduce |
R909 |
T1667 |
T1668 |
det |
these,complexes |
R910 |
T1668 |
T1663 |
nsubj |
complexes,transduce |
R911 |
T1669 |
T1670 |
det |
a,signal |
R912 |
T1670 |
T1663 |
dobj |
signal,transduce |
R913 |
T1671 |
T1663 |
prep |
by,transduce |
R914 |
T1672 |
T1671 |
pcomp |
phosphorylating,by |
R915 |
T1673 |
T1672 |
dobj |
members,phosphorylating |
R916 |
T1674 |
T1673 |
prep |
of,members |
R917 |
T1675 |
T1676 |
det |
the,family |
R918 |
T1676 |
T1674 |
pobj |
family,of |
R919 |
T1677 |
T1676 |
compound |
Smad,family |
R920 |
T1678 |
T1676 |
prep |
of,family |
R921 |
T1679 |
T1680 |
compound |
transcription,factors |
R922 |
T1680 |
T1678 |
pobj |
factors,of |
R923 |
T1681 |
T1682 |
punct |
(,Massague |
R924 |
T1682 |
T1663 |
meta |
Massague,transduce |
R925 |
T1683 |
T1682 |
nummod |
1996,Massague |
R926 |
T1684 |
T1682 |
punct |
),Massague |
R927 |
T1685 |
T1663 |
punct |
.,transduce |
R928 |
T1687 |
T1688 |
amod |
Recent,experiments |
R929 |
T1688 |
T1689 |
nsubj |
experiments,implicated |
R930 |
T1690 |
T1689 |
aux |
have,implicated |
R931 |
T1691 |
T1692 |
nummod |
two,receptors |
R932 |
T1692 |
T1689 |
dative |
receptors,implicated |
R933 |
T1693 |
T1692 |
amod |
different,receptors |
R934 |
T1694 |
T1692 |
nmod |
BMP,receptors |
R935 |
T1695 |
T1692 |
nmod |
type,receptors |
R936 |
T1696 |
T1695 |
nummod |
I,type |
R937 |
T1697 |
T1689 |
prep |
in,implicated |
R938 |
T1698 |
T1699 |
amod |
skeletal,patterning |
R939 |
T1699 |
T1697 |
pobj |
patterning,in |
R940 |
T1700 |
T1689 |
punct |
", ",implicated |
R941 |
T1701 |
T1689 |
dobj |
BMPR1A,implicated |
R942 |
T1702 |
T1701 |
cc |
and,BMPR1A |
R943 |
T1703 |
T1701 |
conj |
BMPR1B,BMPR1A |
R944 |
T1704 |
T1689 |
punct |
.,implicated |
R945 |
T1706 |
T1707 |
det |
Both,receptors |
R946 |
T1707 |
T1708 |
nsubj |
receptors,bind |
R947 |
T1709 |
T1708 |
aux |
can,bind |
R948 |
T1710 |
T1708 |
dobj |
BMP2,bind |
R949 |
T1711 |
T1710 |
punct |
", ",BMP2 |
R950 |
T1712 |
T1710 |
conj |
BMP4,BMP2 |
R951 |
T1713 |
T1712 |
punct |
", ",BMP4 |
R952 |
T1714 |
T1712 |
cc |
and,BMP4 |
R953 |
T1715 |
T1712 |
conj |
GDF5,BMP4 |
R954 |
T1716 |
T1708 |
punct |
", ",bind |
R955 |
T1717 |
T1718 |
mark |
although,shows |
R956 |
T1718 |
T1708 |
advcl |
shows,bind |
R957 |
T1719 |
T1718 |
nsubj |
GDF5,shows |
R958 |
T1720 |
T1721 |
amod |
higher,affinity |
R959 |
T1721 |
T1718 |
dobj |
affinity,shows |
R960 |
T1722 |
T1721 |
prep |
for,affinity |
R961 |
T1723 |
T1722 |
pobj |
BMPR1B,for |
R962 |
T1724 |
T1725 |
punct |
(,Koenig |
R963 |
T1725 |
T1708 |
meta |
Koenig,bind |
R964 |
T1726 |
T1725 |
nmod |
et,Koenig |
R965 |
T1727 |
T1725 |
nmod |
al.,Koenig |
R966 |
T1728 |
T1725 |
nummod |
1994,Koenig |
R967 |
T1729 |
T1725 |
punct |
;,Koenig |
R968 |
T1730 |
T1725 |
nmod |
ten,Koenig |
R969 |
T1731 |
T1725 |
nmod |
Dijke,Koenig |
R970 |
T1732 |
T1725 |
nmod |
et,Koenig |
R971 |
T1733 |
T1725 |
nmod |
al.,Koenig |
R972 |
T1734 |
T1725 |
nummod |
1994,Koenig |
R973 |
T1735 |
T1725 |
punct |
;,Koenig |
R974 |
T1736 |
T1725 |
nmod |
Yamaji,Koenig |
R975 |
T1737 |
T1725 |
nmod |
et,Koenig |
R976 |
T1738 |
T1725 |
nmod |
al.,Koenig |
R977 |
T1739 |
T1725 |
nummod |
1994,Koenig |
R978 |
T1740 |
T1725 |
punct |
;,Koenig |
R979 |
T1741 |
T1725 |
nmod |
Nishitoh,Koenig |
R980 |
T1742 |
T1725 |
nmod |
et,Koenig |
R981 |
T1743 |
T1725 |
nmod |
al.,Koenig |
R982 |
T1744 |
T1725 |
nummod |
1996,Koenig |
R983 |
T1745 |
T1725 |
punct |
;,Koenig |
R984 |
T1746 |
T1725 |
nmod |
Chalaux,Koenig |
R985 |
T1747 |
T1725 |
nmod |
et,Koenig |
R986 |
T1748 |
T1725 |
nmod |
al.,Koenig |
R987 |
T1749 |
T1725 |
nummod |
1998,Koenig |
R988 |
T1750 |
T1725 |
punct |
),Koenig |
R989 |
T1751 |
T1708 |
punct |
.,bind |
R990 |
T1753 |
T1754 |
det |
Both,receptors |
R991 |
T1754 |
T1755 |
nsubjpass |
receptors,expressed |
R992 |
T1756 |
T1755 |
auxpass |
are,expressed |
R993 |
T1757 |
T1755 |
advmod |
also,expressed |
R994 |
T1758 |
T1755 |
prep |
in,expressed |
R995 |
T1759 |
T1760 |
amod |
dynamic,patterns |
R996 |
T1760 |
T1758 |
pobj |
patterns,in |
R997 |
T1802 |
T1801 |
amod |
precartilaginous,cells |
R998 |
T1761 |
T1755 |
prep |
during,expressed |
R999 |
T1803 |
T1801 |
amod |
mesenchymal,cells |