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PMC:523229 / 3719-4953 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T1324 0-7 NNS denotes Studies
T1326 8-12 IN denotes over
T1327 13-16 DT denotes the
T1329 17-21 JJ denotes last
T1330 22-24 CD denotes 10
T1328 25-26 NN denotes y
T1331 27-31 VBP denotes have
T1325 32-37 VBN denotes begun
T1332 38-40 TO denotes to
T1333 41-50 VB denotes elucidate
T1334 51-55 DT denotes some
T1335 56-58 IN denotes of
T1336 59-62 DT denotes the
T1338 63-72 NN denotes signaling
T1337 73-81 NNS denotes pathways
T1339 82-86 WDT denotes that
T1340 87-97 VBP denotes contribute
T1341 98-100 IN denotes to
T1342 101-104 DT denotes the
T1344 105-110 JJ denotes early
T1343 111-117 NNS denotes stages
T1345 118-120 IN denotes of
T1346 121-126 NN denotes joint
T1347 127-136 NN denotes formation
T1348 136-137 . denotes .
T1349 137-342 sentence denotes Wnt14 is expressed in stripes at the sites where joints will form, and it is capable of inducing expression of other joint markers when misexpressed at new locations in the limb (Hartmann and Tabin 2001).
T1350 138-143 NN denotes Wnt14
T1352 144-146 VBZ denotes is
T1351 147-156 VBN denotes expressed
T1353 157-159 IN denotes in
T1354 160-167 NNS denotes stripes
T1355 168-170 IN denotes at
T1356 171-174 DT denotes the
T1357 175-180 NNS denotes sites
T1358 181-186 WRB denotes where
T1360 187-193 NNS denotes joints
T1361 194-198 MD denotes will
T1359 199-203 VB denotes form
T1362 203-205 , denotes ,
T1363 205-208 CC denotes and
T1364 209-211 PRP denotes it
T1365 212-214 VBZ denotes is
T1366 215-222 JJ denotes capable
T1367 223-225 IN denotes of
T1368 226-234 VBG denotes inducing
T1369 235-245 NN denotes expression
T1370 246-248 IN denotes of
T1371 249-254 JJ denotes other
T1373 255-260 NN denotes joint
T1372 261-268 NNS denotes markers
T1374 269-273 WRB denotes when
T1375 274-286 VBN denotes misexpressed
T1376 287-289 IN denotes at
T1377 290-293 JJ denotes new
T1378 294-303 NNS denotes locations
T1379 304-306 IN denotes in
T1380 307-310 DT denotes the
T1381 311-315 NN denotes limb
T1382 316-317 -LRB- denotes (
T1383 317-325 NNP denotes Hartmann
T1384 326-329 CC denotes and
T1385 330-335 NNP denotes Tabin
T1386 336-340 CD denotes 2001
T1387 340-341 -RRB- denotes )
T1388 341-342 . denotes .
T1389 342-664 sentence denotes Several members of the bone morphogenetic protein (BMP) family of secreted signaling molecules are also expressed in stripes at sites where joints will form, including those encoded by the genes Gdf5, Gdf6, Gdf7, Bmp2, and Bmp4 (Storm and Kingsley 1996; Wolfman et al. 1997; Francis-West et al. 1999; Settle et al. 2003).
T1390 343-350 JJ denotes Several
T1391 351-358 NNS denotes members
T1393 359-361 IN denotes of
T1394 362-365 DT denotes the
T1396 366-370 NN denotes bone
T1398 371-384 JJ denotes morphogenetic
T1397 385-392 NN denotes protein
T1399 393-394 -LRB- denotes (
T1400 394-397 NNP denotes BMP
T1401 397-398 -RRB- denotes )
T1395 399-405 NN denotes family
T1402 406-408 IN denotes of
T1403 409-417 VBN denotes secreted
T1405 418-427 NN denotes signaling
T1404 428-437 NNS denotes molecules
T1406 438-441 VBP denotes are
T1407 442-446 RB denotes also
T1392 447-456 VBN denotes expressed
T1408 457-459 IN denotes in
T1409 460-467 NNS denotes stripes
T1410 468-470 IN denotes at
T1411 471-476 NNS denotes sites
T1412 477-482 WRB denotes where
T1414 483-489 NNS denotes joints
T1415 490-494 MD denotes will
T1413 495-499 VB denotes form
T1416 499-501 , denotes ,
T1417 501-510 VBG denotes including
T1418 511-516 DT denotes those
T1419 517-524 VBN denotes encoded
T1420 525-527 IN denotes by
T1421 528-531 DT denotes the
T1422 532-537 NNS denotes genes
T1423 538-542 NN denotes Gdf5
T1424 542-544 , denotes ,
T1425 544-548 NN denotes Gdf6
T1426 548-550 , denotes ,
T1427 550-554 NN denotes Gdf7
T1428 554-556 , denotes ,
T1429 556-560 NN denotes Bmp2
T1430 560-562 , denotes ,
T1431 562-565 CC denotes and
T1432 566-570 NN denotes Bmp4
T1433 571-572 -LRB- denotes (
T1434 572-577 NNP denotes Storm
T1435 578-581 CC denotes and
T1436 582-590 NNP denotes Kingsley
T1437 591-595 CD denotes 1996
T1438 595-596 : denotes ;
T1439 597-604 NNP denotes Wolfman
T1440 605-607 FW denotes et
T1441 608-611 FW denotes al.
T1442 612-616 CD denotes 1997
T1443 616-617 : denotes ;
T1444 618-625 NNP denotes Francis
T1445 625-626 HYPH denotes -
T1446 626-630 NNP denotes West
T1447 631-633 FW denotes et
T1448 634-637 FW denotes al.
T1449 638-642 CD denotes 1999
T1450 642-643 : denotes ;
T1451 644-650 NNP denotes Settle
T1452 651-653 FW denotes et
T1453 654-657 FW denotes al.
T1454 658-662 CD denotes 2003
T1455 662-663 -RRB- denotes )
T1456 663-664 . denotes .
T1457 664-815 sentence denotes Of these, Gdf5 expression is most strikingly limited to regions where joints will develop and is one of the earliest known markers of joint formation.
T1458 665-667 IN denotes Of
T1460 668-673 DT denotes these
T1461 673-675 , denotes ,
T1462 675-679 NN denotes Gdf5
T1463 680-690 NN denotes expression
T1459 691-693 VBZ denotes is
T1464 694-698 RBS denotes most
T1465 699-709 RB denotes strikingly
T1466 710-717 VBN denotes limited
T1467 718-720 IN denotes to
T1468 721-728 NNS denotes regions
T1469 729-734 WRB denotes where
T1471 735-741 NNS denotes joints
T1472 742-746 MD denotes will
T1470 747-754 VB denotes develop
T1473 755-758 CC denotes and
T1474 759-761 VBZ denotes is
T1475 762-765 CD denotes one
T1476 766-768 IN denotes of
T1477 769-772 DT denotes the
T1479 773-781 JJS denotes earliest
T1480 782-787 VBN denotes known
T1478 788-795 NNS denotes markers
T1481 796-798 IN denotes of
T1482 799-804 NN denotes joint
T1483 805-814 NN denotes formation
T1484 814-815 . denotes .
T1485 815-1061 sentence denotes Mutations in either Gdf5 or the closely related Gdf6 gene also block formation of joints at specific locations, providing strong evidence that these molecules are essential for the joint formation process (Storm et al. 1994; Settle et al. 2003).
T1486 816-825 NNS denotes Mutations
T1488 826-828 IN denotes in
T1489 829-835 CC denotes either
T1490 836-840 NN denotes Gdf5
T1491 841-843 CC denotes or
T1492 844-847 DT denotes the
T1494 848-855 RB denotes closely
T1495 856-863 JJ denotes related
T1496 864-868 NN denotes Gdf6
T1493 869-873 NN denotes gene
T1497 874-878 RB denotes also
T1487 879-884 VBP denotes block
T1498 885-894 NN denotes formation
T1499 895-897 IN denotes of
T1500 898-904 NNS denotes joints
T1501 905-907 IN denotes at
T1502 908-916 JJ denotes specific
T1503 917-926 NNS denotes locations
T1504 926-928 , denotes ,
T1505 928-937 VBG denotes providing
T1506 938-944 JJ denotes strong
T1507 945-953 NN denotes evidence
T1508 954-958 IN denotes that
T1510 959-964 DT denotes these
T1511 965-974 NNS denotes molecules
T1509 975-978 VBP denotes are
T1512 979-988 JJ denotes essential
T1513 989-992 IN denotes for
T1514 993-996 DT denotes the
T1516 997-1002 NN denotes joint
T1517 1003-1012 NN denotes formation
T1515 1013-1020 NN denotes process
T1518 1021-1022 -LRB- denotes (
T1519 1022-1027 NNP denotes Storm
T1520 1028-1030 FW denotes et
T1521 1031-1034 FW denotes al.
T1522 1035-1039 CD denotes 1994
T1523 1039-1040 : denotes ;
T1524 1041-1047 NNP denotes Settle
T1525 1048-1050 FW denotes et
T1526 1051-1054 FW denotes al.
T1527 1055-1059 CD denotes 2003
T1528 1059-1060 -RRB- denotes )
T1529 1060-1061 . denotes .
T1530 1061-1234 sentence denotes However, mutations in Bmp2 or Bmp4 cause early embryonic lethality, making it difficult to test their role in joint formation (Winnier et al. 1995; Zhang and Bradley 1996).
T1531 1062-1069 RB denotes However
T1533 1069-1071 , denotes ,
T1534 1071-1080 NNS denotes mutations
T1535 1081-1083 IN denotes in
T1536 1084-1088 NN denotes Bmp2
T1537 1089-1091 CC denotes or
T1538 1092-1096 NN denotes Bmp4
T1532 1097-1102 VBP denotes cause
T1539 1103-1108 JJ denotes early
T1541 1109-1118 JJ denotes embryonic
T1540 1119-1128 NN denotes lethality
T1542 1128-1130 , denotes ,
T1543 1130-1136 VBG denotes making
T1544 1137-1139 PRP denotes it
T1545 1140-1149 JJ denotes difficult
T1546 1150-1152 TO denotes to
T1547 1153-1157 VB denotes test
T1548 1158-1163 PRP$ denotes their
T1549 1164-1168 NN denotes role
T1550 1169-1171 IN denotes in
T1551 1172-1177 NN denotes joint
T1552 1178-1187 NN denotes formation
T1553 1188-1189 -LRB- denotes (
T1554 1189-1196 NNP denotes Winnier
T1555 1197-1199 FW denotes et
T1556 1200-1203 FW denotes al.
T1557 1204-1208 CD denotes 1995
T1558 1208-1209 : denotes ;
T1559 1210-1215 NNP denotes Zhang
T1560 1216-1219 CC denotes and
T1561 1220-1227 NNP denotes Bradley
T1562 1228-1232 CD denotes 1996
T1563 1232-1233 -RRB- denotes )
T1564 1233-1234 . denotes .
R585 T1324 T1325 nsubj Studies,begun
R586 T1326 T1324 prep over,Studies
R587 T1327 T1328 det the,y
R588 T1328 T1326 pobj y,over
R589 T1329 T1328 amod last,y
R590 T1330 T1328 nummod 10,y
R591 T1331 T1325 aux have,begun
R592 T1332 T1333 aux to,elucidate
R593 T1333 T1325 xcomp elucidate,begun
R594 T1334 T1333 dobj some,elucidate
R595 T1335 T1334 prep of,some
R596 T1336 T1337 det the,pathways
R597 T1337 T1335 pobj pathways,of
R598 T1338 T1337 compound signaling,pathways
R599 T1339 T1340 dep that,contribute
R600 T1340 T1337 relcl contribute,pathways
R601 T1341 T1340 prep to,contribute
R602 T1342 T1343 det the,stages
R603 T1343 T1341 pobj stages,to
R604 T1344 T1343 amod early,stages
R605 T1345 T1343 prep of,stages
R606 T1346 T1347 compound joint,formation
R607 T1347 T1345 pobj formation,of
R608 T1348 T1325 punct .,begun
R609 T1350 T1351 nsubjpass Wnt14,expressed
R610 T1352 T1351 auxpass is,expressed
R611 T1353 T1351 prep in,expressed
R612 T1354 T1353 pobj stripes,in
R613 T1355 T1351 prep at,expressed
R614 T1356 T1357 det the,sites
R615 T1357 T1355 pobj sites,at
R616 T1358 T1359 advmod where,form
R617 T1359 T1357 relcl form,sites
R618 T1360 T1359 nsubj joints,form
R619 T1361 T1359 aux will,form
R620 T1362 T1351 punct ", ",expressed
R621 T1363 T1351 cc and,expressed
R622 T1364 T1365 nsubj it,is
R623 T1365 T1351 conj is,expressed
R624 T1366 T1365 acomp capable,is
R625 T1367 T1366 prep of,capable
R626 T1368 T1367 pcomp inducing,of
R627 T1369 T1368 dobj expression,inducing
R628 T1370 T1369 prep of,expression
R629 T1371 T1372 amod other,markers
R630 T1372 T1370 pobj markers,of
R631 T1373 T1372 compound joint,markers
R632 T1374 T1375 advmod when,misexpressed
R633 T1375 T1365 advcl misexpressed,is
R634 T1376 T1375 prep at,misexpressed
R635 T1377 T1378 amod new,locations
R636 T1378 T1376 pobj locations,at
R637 T1379 T1378 prep in,locations
R638 T1380 T1381 det the,limb
R639 T1381 T1379 pobj limb,in
R640 T1382 T1383 punct (,Hartmann
R641 T1383 T1365 meta Hartmann,is
R642 T1384 T1383 cc and,Hartmann
R643 T1385 T1383 conj Tabin,Hartmann
R644 T1386 T1385 nummod 2001,Tabin
R645 T1387 T1385 punct ),Tabin
R646 T1388 T1365 punct .,is
R647 T1390 T1391 amod Several,members
R648 T1391 T1392 nsubjpass members,expressed
R649 T1393 T1391 prep of,members
R650 T1394 T1395 det the,family
R651 T1395 T1393 pobj family,of
R652 T1396 T1397 nmod bone,protein
R653 T1397 T1395 nmod protein,family
R654 T1398 T1397 amod morphogenetic,protein
R655 T1399 T1400 punct (,BMP
R656 T1400 T1397 appos BMP,protein
R657 T1401 T1400 punct ),BMP
R658 T1402 T1395 prep of,family
R659 T1403 T1404 amod secreted,molecules
R660 T1404 T1402 pobj molecules,of
R661 T1405 T1404 compound signaling,molecules
R662 T1406 T1392 auxpass are,expressed
R663 T1407 T1392 advmod also,expressed
R664 T1408 T1392 prep in,expressed
R665 T1409 T1408 pobj stripes,in
R666 T1410 T1392 prep at,expressed
R667 T1411 T1410 pobj sites,at
R668 T1412 T1413 advmod where,form
R669 T1413 T1411 relcl form,sites
R670 T1414 T1413 nsubj joints,form
R671 T1415 T1413 aux will,form
R672 T1416 T1411 punct ", ",sites
R673 T1417 T1411 prep including,sites
R674 T1418 T1417 pobj those,including
R675 T1419 T1418 acl encoded,those
R676 T1420 T1419 agent by,encoded
R677 T1421 T1422 det the,genes
R678 T1422 T1420 pobj genes,by
R679 T1423 T1422 appos Gdf5,genes
R680 T1424 T1423 punct ", ",Gdf5
R681 T1425 T1423 conj Gdf6,Gdf5
R682 T1426 T1425 punct ", ",Gdf6
R683 T1427 T1425 conj Gdf7,Gdf6
R684 T1428 T1427 punct ", ",Gdf7
R685 T1429 T1427 conj Bmp2,Gdf7
R686 T1430 T1429 punct ", ",Bmp2
R687 T1431 T1429 cc and,Bmp2
R688 T1432 T1429 conj Bmp4,Bmp2
R689 T1433 T1434 punct (,Storm
R690 T1434 T1392 meta Storm,expressed
R691 T1435 T1434 cc and,Storm
R692 T1436 T1434 conj Kingsley,Storm
R693 T1437 T1436 nummod 1996,Kingsley
R694 T1438 T1436 punct ;,Kingsley
R695 T1439 T1436 conj Wolfman,Kingsley
R696 T1440 T1439 nmod et,Wolfman
R697 T1441 T1439 nmod al.,Wolfman
R698 T1442 T1439 nummod 1997,Wolfman
R699 T1443 T1439 punct ;,Wolfman
R700 T1444 T1439 conj Francis,Wolfman
R701 T1445 T1444 punct -,Francis
R702 T1446 T1444 nmod West,Francis
R703 T1447 T1444 nmod et,Francis
R704 T1448 T1444 nmod al.,Francis
R705 T1449 T1444 nummod 1999,Francis
R706 T1450 T1444 punct ;,Francis
R707 T1451 T1444 conj Settle,Francis
R708 T1452 T1451 nmod et,Settle
R709 T1453 T1451 nmod al.,Settle
R710 T1454 T1451 nummod 2003,Settle
R711 T1455 T1451 punct ),Settle
R712 T1456 T1392 punct .,expressed
R713 T1458 T1459 prep Of,is
R714 T1460 T1458 pobj these,Of
R715 T1461 T1459 punct ", ",is
R716 T1462 T1463 compound Gdf5,expression
R717 T1463 T1459 nsubj expression,is
R718 T1464 T1465 advmod most,strikingly
R719 T1465 T1466 advmod strikingly,limited
R720 T1466 T1459 acomp limited,is
R721 T1467 T1466 prep to,limited
R722 T1468 T1467 pobj regions,to
R723 T1469 T1470 advmod where,develop
R724 T1470 T1468 relcl develop,regions
R725 T1471 T1470 nsubj joints,develop
R726 T1472 T1470 aux will,develop
R727 T1473 T1459 cc and,is
R728 T1474 T1459 conj is,is
R729 T1475 T1474 attr one,is
R730 T1476 T1475 prep of,one
R731 T1477 T1478 det the,markers
R732 T1478 T1476 pobj markers,of
R733 T1479 T1480 amod earliest,known
R734 T1480 T1478 amod known,markers
R735 T1481 T1478 prep of,markers
R736 T1482 T1483 compound joint,formation
R737 T1483 T1481 pobj formation,of
R738 T1484 T1459 punct .,is
R739 T1486 T1487 nsubj Mutations,block
R740 T1488 T1486 prep in,Mutations
R741 T1489 T1490 preconj either,Gdf5
R742 T1490 T1488 pobj Gdf5,in
R743 T1491 T1490 cc or,Gdf5
R744 T1492 T1493 det the,gene
R745 T1493 T1490 conj gene,Gdf5
R746 T1494 T1495 advmod closely,related
R747 T1495 T1493 amod related,gene
R748 T1496 T1493 compound Gdf6,gene
R749 T1497 T1487 advmod also,block
R750 T1498 T1487 dobj formation,block
R751 T1499 T1498 prep of,formation
R752 T1500 T1499 pobj joints,of
R753 T1501 T1498 prep at,formation
R754 T1502 T1503 amod specific,locations
R755 T1503 T1501 pobj locations,at
R756 T1504 T1487 punct ", ",block
R757 T1505 T1487 advcl providing,block
R758 T1506 T1507 amod strong,evidence
R759 T1507 T1505 dobj evidence,providing
R760 T1508 T1509 mark that,are
R761 T1509 T1507 acl are,evidence
R762 T1510 T1511 det these,molecules
R763 T1511 T1509 nsubj molecules,are
R764 T1512 T1509 acomp essential,are
R765 T1513 T1512 prep for,essential
R766 T1514 T1515 det the,process
R767 T1515 T1513 pobj process,for
R768 T1516 T1517 compound joint,formation
R769 T1517 T1515 compound formation,process
R770 T1518 T1519 punct (,Storm
R771 T1519 T1487 meta Storm,block
R772 T1520 T1519 nmod et,Storm
R773 T1521 T1519 nmod al.,Storm
R774 T1522 T1519 nummod 1994,Storm
R775 T1523 T1519 punct ;,Storm
R776 T1524 T1519 nmod Settle,Storm
R777 T1525 T1519 nmod et,Storm
R778 T1526 T1519 nmod al.,Storm
R779 T1527 T1519 nummod 2003,Storm
R780 T1528 T1519 punct ),Storm
R781 T1529 T1487 punct .,block
R782 T1531 T1532 advmod However,cause
R783 T1533 T1532 punct ", ",cause
R784 T1534 T1532 nsubj mutations,cause
R785 T1535 T1534 prep in,mutations
R786 T1536 T1535 pobj Bmp2,in
R787 T1537 T1536 cc or,Bmp2
R788 T1538 T1536 conj Bmp4,Bmp2
R789 T1539 T1540 amod early,lethality
R790 T1540 T1532 dobj lethality,cause
R791 T1541 T1540 amod embryonic,lethality
R792 T1542 T1532 punct ", ",cause
R793 T1543 T1532 advcl making,cause
R794 T1544 T1545 nsubj it,difficult
R795 T1545 T1543 ccomp difficult,making
R796 T1546 T1547 aux to,test
R797 T1547 T1545 advcl test,difficult
R798 T1548 T1549 poss their,role
R799 T1549 T1547 dobj role,test
R800 T1550 T1549 prep in,role
R801 T1551 T1552 compound joint,formation
R802 T1552 T1550 pobj formation,in
R803 T1553 T1554 punct (,Winnier
R804 T1554 T1532 meta Winnier,cause
R805 T1555 T1554 nmod et,Winnier
R806 T1556 T1554 nmod al.,Winnier
R807 T1557 T1554 nummod 1995,Winnier
R808 T1558 T1554 punct ;,Winnier
R809 T1559 T1554 conj Zhang,Winnier
R810 T1560 T1559 cc and,Zhang
R811 T1561 T1559 conj Bradley,Zhang
R812 T1562 T1561 nummod 1996,Bradley
R813 T1563 T1561 punct ),Bradley
R814 T1564 T1532 punct .,cause