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PMC:523229 / 28770-30624 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T6265 0-2 IN denotes By
T6267 3-4 CD denotes 1
T6268 5-7 NN denotes wk
T6269 8-13 IN denotes after
T6270 14-19 NN denotes birth
T6271 19-21 , denotes ,
T6272 21-28 JJ denotes obvious
T6273 29-40 NNS denotes differences
T6266 41-46 VBD denotes began
T6274 47-49 TO denotes to
T6276 50-52 VB denotes be
T6275 53-61 VBN denotes detected
T6277 62-64 IN denotes in
T6278 65-68 DT denotes the
T6280 69-78 JJ denotes articular
T6279 79-86 NNS denotes regions
T6281 87-89 IN denotes of
T6282 90-96 NN denotes mutant
T6283 97-104 NNS denotes animals
T6284 104-105 . denotes .
T6285 105-255 sentence denotes The expression of Col2a1 was reduced throughout the articular surfaces of the carpals, metacarpals, and phalanges of the forefeet (unpublished data).
T6286 106-109 DT denotes The
T6287 110-120 NN denotes expression
T6289 121-123 IN denotes of
T6290 124-130 NN denotes Col2a1
T6291 131-134 VBD denotes was
T6288 135-142 VBN denotes reduced
T6292 143-153 IN denotes throughout
T6293 154-157 DT denotes the
T6295 158-167 JJ denotes articular
T6294 168-176 NNS denotes surfaces
T6296 177-179 IN denotes of
T6297 180-183 DT denotes the
T6298 184-191 NNS denotes carpals
T6299 191-193 , denotes ,
T6300 193-204 NNS denotes metacarpals
T6301 204-206 , denotes ,
T6302 206-209 CC denotes and
T6303 210-219 NNS denotes phalanges
T6304 220-222 IN denotes of
T6305 223-226 DT denotes the
T6306 227-235 NNS denotes forefeet
T6307 236-237 -LRB- denotes (
T6309 237-248 JJ denotes unpublished
T6308 249-253 NNS denotes data
T6310 253-254 -RRB- denotes )
T6311 254-255 . denotes .
T6312 255-375 sentence denotes Less severe reductions were also seen in articular cells of tarsals and metatarsals in the hindfeet (unpublished data).
T6313 256-260 RBR denotes Less
T6314 261-267 JJ denotes severe
T6315 268-278 NNS denotes reductions
T6317 279-283 VBD denotes were
T6318 284-288 RB denotes also
T6316 289-293 VBN denotes seen
T6319 294-296 IN denotes in
T6320 297-306 JJ denotes articular
T6321 307-312 NNS denotes cells
T6322 313-315 IN denotes of
T6323 316-323 NNS denotes tarsals
T6324 324-327 CC denotes and
T6325 328-339 NNS denotes metatarsals
T6326 340-342 IN denotes in
T6327 343-346 DT denotes the
T6328 347-355 NN denotes hindfeet
T6329 356-357 -LRB- denotes (
T6331 357-368 JJ denotes unpublished
T6330 369-373 NNS denotes data
T6332 373-374 -RRB- denotes )
T6333 374-375 . denotes .
T6334 375-755 sentence denotes By 2 wk of age, Col2a1 expression was reduced in most cells of the articular region (Figure 5L and 5Q), accompanied by markedly reduced Safranin O staining (Figure 5K and 5P), and decreased expression of Agg and two genes normally expressed in more mature articular cartilage cells, Collagen 3 (Col3a1) and Collagen 10 (Col10a1) (Figure 5M and 5R) (unpublished data) (Eyre 2002).
T6335 376-378 IN denotes By
T6337 379-380 CD denotes 2
T6338 381-383 NNS denotes wk
T6339 384-386 IN denotes of
T6340 387-390 NN denotes age
T6341 390-392 , denotes ,
T6342 392-398 NN denotes Col2a1
T6343 399-409 NN denotes expression
T6344 410-413 VBD denotes was
T6336 414-421 VBN denotes reduced
T6345 422-424 IN denotes in
T6346 425-429 JJS denotes most
T6347 430-435 NNS denotes cells
T6348 436-438 IN denotes of
T6349 439-442 DT denotes the
T6351 443-452 JJ denotes articular
T6350 453-459 NN denotes region
T6352 460-461 -LRB- denotes (
T6353 461-467 NN denotes Figure
T6354 468-470 CD denotes 5L
T6355 471-474 CC denotes and
T6356 475-477 CD denotes 5Q
T6357 477-478 -RRB- denotes )
T6358 478-480 , denotes ,
T6359 480-491 VBN denotes accompanied
T6360 492-494 IN denotes by
T6361 495-503 RB denotes markedly
T6362 504-511 VBN denotes reduced
T6364 512-520 NN denotes Safranin
T6365 521-522 NN denotes O
T6363 523-531 NN denotes staining
T6366 532-533 -LRB- denotes (
T6367 533-539 NN denotes Figure
T6368 540-542 CD denotes 5K
T6369 543-546 CC denotes and
T6370 547-549 CD denotes 5P
T6371 549-550 -RRB- denotes )
T6372 550-552 , denotes ,
T6373 552-555 CC denotes and
T6374 556-565 VBN denotes decreased
T6375 566-576 NN denotes expression
T6376 577-579 IN denotes of
T6377 580-583 NN denotes Agg
T6378 584-587 CC denotes and
T6379 588-591 CD denotes two
T6380 592-597 NNS denotes genes
T6381 598-606 RB denotes normally
T6382 607-616 VBN denotes expressed
T6383 617-619 IN denotes in
T6384 620-624 RBR denotes more
T6385 625-631 JJ denotes mature
T6387 632-641 JJ denotes articular
T6388 642-651 NN denotes cartilage
T6386 652-657 NNS denotes cells
T6389 657-659 , denotes ,
T6390 659-667 NN denotes Collagen
T6391 668-669 CD denotes 3
T6392 670-671 -LRB- denotes (
T6393 671-677 NN denotes Col3a1
T6394 677-678 -RRB- denotes )
T6395 679-682 CC denotes and
T6396 683-691 NN denotes Collagen
T6397 692-694 CD denotes 10
T6398 695-696 -LRB- denotes (
T6399 696-703 NN denotes Col10a1
T6400 703-704 -RRB- denotes )
T6401 705-706 -LRB- denotes (
T6402 706-712 NN denotes Figure
T6403 713-715 CD denotes 5M
T6404 716-719 CC denotes and
T6405 720-722 CD denotes 5R
T6406 722-723 -RRB- denotes )
T6407 724-725 -LRB- denotes (
T6409 725-736 JJ denotes unpublished
T6408 737-741 NNS denotes data
T6410 741-742 -RRB- denotes )
T6411 743-744 -LRB- denotes (
T6412 744-748 NN denotes Eyre
T6413 749-753 CD denotes 2002
T6414 753-754 -RRB- denotes )
T6415 754-755 . denotes .
T6416 755-997 sentence denotes Inhibition of BMP signaling in cultured chondrocytes has previously been reported to induce Collagen 1 (Col1a1) expression, increase proliferation, and result in cells with flattened, fibroblast-like morphology (Enomoto-Iwamoto et al. 1998).
T6417 756-766 NN denotes Inhibition
T6419 767-769 IN denotes of
T6420 770-773 NN denotes BMP
T6421 774-783 NN denotes signaling
T6422 784-786 IN denotes in
T6423 787-795 VBN denotes cultured
T6424 796-808 NNS denotes chondrocytes
T6425 809-812 VBZ denotes has
T6426 813-823 RB denotes previously
T6427 824-828 VBN denotes been
T6418 829-837 VBN denotes reported
T6428 838-840 TO denotes to
T6429 841-847 VB denotes induce
T6430 848-856 NN denotes Collagen
T6432 857-858 CD denotes 1
T6433 859-860 -LRB- denotes (
T6434 860-866 NN denotes Col1a1
T6435 866-867 -RRB- denotes )
T6431 868-878 NN denotes expression
T6436 878-880 , denotes ,
T6437 880-888 VB denotes increase
T6438 889-902 NN denotes proliferation
T6439 902-904 , denotes ,
T6440 904-907 CC denotes and
T6441 908-914 VB denotes result
T6442 915-917 IN denotes in
T6443 918-923 NNS denotes cells
T6444 924-928 IN denotes with
T6445 929-938 VBN denotes flattened
T6447 938-940 , denotes ,
T6448 940-950 NN denotes fibroblast
T6450 950-951 HYPH denotes -
T6449 951-955 JJ denotes like
T6446 956-966 NN denotes morphology
T6451 967-968 -LRB- denotes (
T6452 968-975 NNP denotes Enomoto
T6453 975-976 HYPH denotes -
T6454 976-983 NNP denotes Iwamoto
T6455 984-986 FW denotes et
T6456 987-990 FW denotes al.
T6457 991-995 CD denotes 1998
T6458 995-996 -RRB- denotes )
T6459 996-997 . denotes .
T6460 997-1193 sentence denotes However, we saw no increase in the expression of Col1a1 in mutant articular cartilage, and no proliferation was detected in articular cells of either mutant or control animals (unpublished data).
T6461 998-1005 RB denotes However
T6463 1005-1007 , denotes ,
T6464 1007-1009 PRP denotes we
T6462 1010-1013 VBD denotes saw
T6465 1014-1016 DT denotes no
T6466 1017-1025 NN denotes increase
T6467 1026-1028 IN denotes in
T6468 1029-1032 DT denotes the
T6469 1033-1043 NN denotes expression
T6470 1044-1046 IN denotes of
T6471 1047-1053 NN denotes Col1a1
T6472 1054-1056 IN denotes in
T6473 1057-1063 NN denotes mutant
T6475 1064-1073 JJ denotes articular
T6474 1074-1083 NN denotes cartilage
T6476 1083-1085 , denotes ,
T6477 1085-1088 CC denotes and
T6478 1089-1091 DT denotes no
T6479 1092-1105 NN denotes proliferation
T6481 1106-1109 VBD denotes was
T6480 1110-1118 VBN denotes detected
T6482 1119-1121 IN denotes in
T6483 1122-1131 JJ denotes articular
T6484 1132-1137 NNS denotes cells
T6485 1138-1140 IN denotes of
T6486 1141-1147 CC denotes either
T6487 1148-1154 JJ denotes mutant
T6489 1155-1157 CC denotes or
T6490 1158-1165 NN denotes control
T6488 1166-1173 NNS denotes animals
T6491 1174-1175 -LRB- denotes (
T6493 1175-1186 JJ denotes unpublished
T6492 1187-1191 NNS denotes data
T6494 1191-1192 -RRB- denotes )
T6495 1192-1193 . denotes .
T6496 1193-1424 sentence denotes While recombined LACZ marker expression was detected in most articular cartilage cells, it was also observed in scattered subarticular chondrocytes, growth plate chondrocytes, and osteoblasts (Figure 5O and 5T) (unpublished data).
T6497 1194-1199 IN denotes While
T6499 1200-1210 VBN denotes recombined
T6501 1211-1215 NN denotes LACZ
T6502 1216-1222 NN denotes marker
T6500 1223-1233 NN denotes expression
T6503 1234-1237 VBD denotes was
T6498 1238-1246 VBN denotes detected
T6505 1247-1249 IN denotes in
T6506 1250-1254 JJS denotes most
T6508 1255-1264 JJ denotes articular
T6509 1265-1274 NN denotes cartilage
T6507 1275-1280 NNS denotes cells
T6510 1280-1282 , denotes ,
T6511 1282-1284 PRP denotes it
T6512 1285-1288 VBD denotes was
T6513 1289-1293 RB denotes also
T6504 1294-1302 VBN denotes observed
T6514 1303-1305 IN denotes in
T6515 1306-1315 VBN denotes scattered
T6517 1316-1328 JJ denotes subarticular
T6516 1329-1341 NNS denotes chondrocytes
T6518 1341-1343 , denotes ,
T6519 1343-1349 NN denotes growth
T6520 1350-1355 NN denotes plate
T6521 1356-1368 NNS denotes chondrocytes
T6522 1368-1370 , denotes ,
T6523 1370-1373 CC denotes and
T6524 1374-1385 NNS denotes osteoblasts
T6525 1386-1387 -LRB- denotes (
T6526 1387-1393 NN denotes Figure
T6527 1394-1396 CD denotes 5O
T6528 1397-1400 CC denotes and
T6529 1401-1403 CD denotes 5T
T6530 1403-1404 -RRB- denotes )
T6531 1405-1406 -LRB- denotes (
T6533 1406-1417 JJ denotes unpublished
T6532 1418-1422 NNS denotes data
T6534 1422-1423 -RRB- denotes )
T6535 1423-1424 . denotes .
T6536 1424-1566 sentence denotes Although this implies that BMP signaling was defective in multiple cell types, the observed defects were confined to the articular cartilage.
T6537 1425-1433 IN denotes Although
T6539 1434-1438 DT denotes this
T6538 1439-1446 VBZ denotes implies
T6541 1447-1451 IN denotes that
T6543 1452-1455 NN denotes BMP
T6544 1456-1465 NN denotes signaling
T6542 1466-1469 VBD denotes was
T6545 1470-1479 JJ denotes defective
T6546 1480-1482 IN denotes in
T6547 1483-1491 JJ denotes multiple
T6549 1492-1496 NN denotes cell
T6548 1497-1502 NNS denotes types
T6550 1502-1504 , denotes ,
T6551 1504-1507 DT denotes the
T6553 1508-1516 VBN denotes observed
T6552 1517-1524 NNS denotes defects
T6554 1525-1529 VBD denotes were
T6540 1530-1538 VBN denotes confined
T6555 1539-1541 IN denotes to
T6556 1542-1545 DT denotes the
T6558 1546-1555 JJ denotes articular
T6557 1556-1565 NN denotes cartilage
T6559 1565-1566 . denotes .
T6560 1566-1664 sentence denotes For example, Osteocalcin and Col1a1 expression appeared normal in osteoblasts (unpublished data).
T6561 1567-1570 IN denotes For
T6563 1571-1578 NN denotes example
T6564 1578-1580 , denotes ,
T6565 1580-1591 NN denotes Osteocalcin
T6567 1592-1595 CC denotes and
T6568 1596-1602 NN denotes Col1a1
T6566 1603-1613 NN denotes expression
T6562 1614-1622 VBD denotes appeared
T6569 1623-1629 JJ denotes normal
T6570 1630-1632 IN denotes in
T6571 1633-1644 NNS denotes osteoblasts
T6572 1645-1646 -LRB- denotes (
T6574 1646-1657 JJ denotes unpublished
T6573 1658-1662 NNS denotes data
T6575 1662-1663 -RRB- denotes )
T6576 1663-1664 . denotes .
T6577 1664-1854 sentence denotes Together, these data suggest that BMPR1A activity is required in postnatal joint articular cartilage to maintain expression of many genes encoding structural components of cartilage matrix.
T6578 1665-1673 RB denotes Together
T6580 1673-1675 , denotes ,
T6581 1675-1680 DT denotes these
T6582 1681-1685 NNS denotes data
T6579 1686-1693 VBP denotes suggest
T6583 1694-1698 IN denotes that
T6585 1699-1705 NN denotes BMPR1A
T6586 1706-1714 NN denotes activity
T6587 1715-1717 VBZ denotes is
T6584 1718-1726 VBN denotes required
T6588 1727-1729 IN denotes in
T6589 1730-1739 JJ denotes postnatal
T6591 1740-1745 NN denotes joint
T6592 1746-1755 JJ denotes articular
T6590 1756-1765 NN denotes cartilage
T6593 1766-1768 TO denotes to
T6594 1769-1777 VB denotes maintain
T6595 1778-1788 NN denotes expression
T6596 1789-1791 IN denotes of
T6597 1792-1796 JJ denotes many
T6598 1797-1802 NNS denotes genes
T6599 1803-1811 VBG denotes encoding
T6600 1812-1822 JJ denotes structural
T6601 1823-1833 NNS denotes components
T6602 1834-1836 IN denotes of
T6603 1837-1846 NN denotes cartilage
T6604 1847-1853 NN denotes matrix
T6605 1853-1854 . denotes .
R3908 T6265 T6266 prep By,began
R3909 T6267 T6268 nummod 1,wk
R3910 T6268 T6265 pobj wk,By
R3911 T6269 T6268 prep after,wk
R3912 T6270 T6269 pobj birth,after
R3913 T6271 T6266 punct ", ",began
R3914 T6272 T6273 amod obvious,differences
R3915 T6273 T6266 nsubj differences,began
R3916 T6274 T6275 aux to,detected
R3917 T6275 T6266 xcomp detected,began
R3918 T6276 T6275 auxpass be,detected
R3919 T6277 T6275 prep in,detected
R3920 T6278 T6279 det the,regions
R3921 T6279 T6277 pobj regions,in
R3922 T6280 T6279 amod articular,regions
R3923 T6281 T6279 prep of,regions
R3924 T6282 T6283 compound mutant,animals
R3925 T6283 T6281 pobj animals,of
R3926 T6284 T6266 punct .,began
R3927 T6286 T6287 det The,expression
R3928 T6287 T6288 nsubjpass expression,reduced
R3929 T6289 T6287 prep of,expression
R3930 T6290 T6289 pobj Col2a1,of
R3931 T6291 T6288 auxpass was,reduced
R3932 T6292 T6288 prep throughout,reduced
R3933 T6293 T6294 det the,surfaces
R3934 T6294 T6292 pobj surfaces,throughout
R3935 T6295 T6294 amod articular,surfaces
R3936 T6296 T6294 prep of,surfaces
R3937 T6297 T6298 det the,carpals
R3938 T6298 T6296 pobj carpals,of
R3939 T6299 T6298 punct ", ",carpals
R3940 T6300 T6298 conj metacarpals,carpals
R3941 T6301 T6300 punct ", ",metacarpals
R3942 T6302 T6300 cc and,metacarpals
R3943 T6303 T6300 conj phalanges,metacarpals
R3944 T6304 T6298 prep of,carpals
R3945 T6305 T6306 det the,forefeet
R3946 T6306 T6304 pobj forefeet,of
R3947 T6307 T6308 punct (,data
R3948 T6308 T6288 meta data,reduced
R3949 T6309 T6308 amod unpublished,data
R3950 T6310 T6308 punct ),data
R3951 T6311 T6288 punct .,reduced
R3952 T6313 T6314 advmod Less,severe
R3953 T6314 T6315 amod severe,reductions
R3954 T6315 T6316 nsubjpass reductions,seen
R3955 T6317 T6316 auxpass were,seen
R3956 T6318 T6316 advmod also,seen
R3957 T6319 T6316 prep in,seen
R3958 T6320 T6321 amod articular,cells
R3959 T6321 T6319 pobj cells,in
R3960 T6322 T6321 prep of,cells
R3961 T6323 T6322 pobj tarsals,of
R3962 T6324 T6323 cc and,tarsals
R3963 T6325 T6323 conj metatarsals,tarsals
R3964 T6326 T6323 prep in,tarsals
R3965 T6327 T6328 det the,hindfeet
R3966 T6328 T6326 pobj hindfeet,in
R3967 T6329 T6330 punct (,data
R3968 T6330 T6316 meta data,seen
R3969 T6331 T6330 amod unpublished,data
R3970 T6332 T6330 punct ),data
R3971 T6333 T6316 punct .,seen
R3972 T6335 T6336 prep By,reduced
R3973 T6337 T6338 nummod 2,wk
R3974 T6338 T6335 pobj wk,By
R3975 T6339 T6338 prep of,wk
R3976 T6340 T6339 pobj age,of
R3977 T6341 T6336 punct ", ",reduced
R3978 T6342 T6343 compound Col2a1,expression
R3979 T6343 T6336 nsubjpass expression,reduced
R3980 T6344 T6336 auxpass was,reduced
R3981 T6345 T6336 prep in,reduced
R3982 T6346 T6347 amod most,cells
R3983 T6347 T6345 pobj cells,in
R3984 T6348 T6347 prep of,cells
R3985 T6349 T6350 det the,region
R3986 T6350 T6348 pobj region,of
R3987 T6351 T6350 amod articular,region
R3988 T6352 T6353 punct (,Figure
R3989 T6353 T6336 parataxis Figure,reduced
R3990 T6354 T6353 nummod 5L,Figure
R3991 T6355 T6353 cc and,Figure
R3992 T6356 T6353 conj 5Q,Figure
R3993 T6357 T6353 punct ),Figure
R3994 T6358 T6336 punct ", ",reduced
R3995 T6359 T6336 advcl accompanied,reduced
R3996 T6360 T6359 agent by,accompanied
R3997 T6361 T6362 advmod markedly,reduced
R3998 T6362 T6363 amod reduced,staining
R3999 T6363 T6360 pobj staining,by
R4000 T6364 T6365 compound Safranin,O
R4001 T6365 T6363 compound O,staining
R4002 T6366 T6367 punct (,Figure
R4003 T6367 T6363 parataxis Figure,staining
R4004 T6368 T6367 nummod 5K,Figure
R4005 T6369 T6367 cc and,Figure
R4006 T6370 T6367 conj 5P,Figure
R4007 T6371 T6367 punct ),Figure
R4008 T6372 T6363 punct ", ",staining
R4009 T6373 T6363 cc and,staining
R4010 T6374 T6375 amod decreased,expression
R4011 T6375 T6363 conj expression,staining
R4012 T6376 T6375 prep of,expression
R4013 T6377 T6376 pobj Agg,of
R4014 T6378 T6377 cc and,Agg
R4015 T6379 T6380 nummod two,genes
R4016 T6380 T6377 conj genes,Agg
R4017 T6381 T6382 advmod normally,expressed
R4018 T6382 T6380 acl expressed,genes
R4019 T6383 T6382 prep in,expressed
R4020 T6384 T6385 advmod more,mature
R4021 T6385 T6386 amod mature,cells
R4022 T6386 T6383 pobj cells,in
R4023 T6387 T6388 amod articular,cartilage
R4024 T6388 T6386 compound cartilage,cells
R4025 T6389 T6380 punct ", ",genes
R4026 T6390 T6380 appos Collagen,genes
R4027 T6391 T6390 nummod 3,Collagen
R4028 T6392 T6390 punct (,Collagen
R4029 T6393 T6390 appos Col3a1,Collagen
R4030 T6394 T6390 punct ),Collagen
R4031 T6395 T6390 cc and,Collagen
R4032 T6396 T6390 conj Collagen,Collagen
R4033 T6397 T6396 nummod 10,Collagen
R4034 T6398 T6396 punct (,Collagen
R4035 T6399 T6396 appos Col10a1,Collagen
R4036 T6400 T6396 punct ),Collagen
R4037 T6401 T6402 punct (,Figure
R4038 T6402 T6336 parataxis Figure,reduced
R4039 T6403 T6402 nummod 5M,Figure
R4040 T6404 T6402 cc and,Figure
R4041 T6405 T6402 conj 5R,Figure
R4042 T6406 T6402 punct ),Figure
R4043 T6407 T6408 punct (,data
R4044 T6408 T6336 meta data,reduced
R4045 T6409 T6408 amod unpublished,data
R4046 T6410 T6408 punct ),data
R4047 T6411 T6412 punct (,Eyre
R4048 T6412 T6336 meta Eyre,reduced
R4049 T6413 T6412 nummod 2002,Eyre
R4050 T6414 T6412 punct ),Eyre
R4051 T6415 T6336 punct .,reduced
R4052 T6417 T6418 nsubjpass Inhibition,reported
R4053 T6419 T6417 prep of,Inhibition
R4054 T6420 T6421 compound BMP,signaling
R4055 T6421 T6419 pobj signaling,of
R4056 T6422 T6417 prep in,Inhibition
R4057 T6423 T6424 amod cultured,chondrocytes
R4058 T6424 T6422 pobj chondrocytes,in
R4059 T6425 T6418 aux has,reported
R4060 T6426 T6418 advmod previously,reported
R4061 T6427 T6418 auxpass been,reported
R4062 T6428 T6429 aux to,induce
R4063 T6429 T6418 xcomp induce,reported
R4064 T6430 T6431 nmod Collagen,expression
R4065 T6431 T6429 dobj expression,induce
R4066 T6432 T6430 nummod 1,Collagen
R4067 T6433 T6430 punct (,Collagen
R4068 T6434 T6430 appos Col1a1,Collagen
R4069 T6435 T6430 punct ),Collagen
R4070 T6436 T6429 punct ", ",induce
R4071 T6437 T6429 conj increase,induce
R4072 T6438 T6437 dobj proliferation,increase
R4073 T6439 T6437 punct ", ",increase
R4074 T6440 T6437 cc and,increase
R4075 T6441 T6437 conj result,increase
R4076 T6442 T6441 prep in,result
R4077 T6443 T6442 pobj cells,in
R4078 T6444 T6443 prep with,cells
R4079 T6445 T6446 amod flattened,morphology
R4080 T6446 T6444 pobj morphology,with
R4081 T6447 T6446 punct ", ",morphology
R4082 T6448 T6449 npadvmod fibroblast,like
R4083 T6449 T6446 amod like,morphology
R4084 T6450 T6449 punct -,like
R4085 T6451 T6452 punct (,Enomoto
R4086 T6452 T6418 meta Enomoto,reported
R4087 T6453 T6452 punct -,Enomoto
R4088 T6454 T6452 nmod Iwamoto,Enomoto
R4089 T6455 T6452 nmod et,Enomoto
R4090 T6456 T6452 nmod al.,Enomoto
R4091 T6457 T6452 nummod 1998,Enomoto
R4092 T6458 T6452 punct ),Enomoto
R4093 T6459 T6418 punct .,reported
R4094 T6461 T6462 advmod However,saw
R4095 T6463 T6462 punct ", ",saw
R4096 T6464 T6462 nsubj we,saw
R4097 T6465 T6466 det no,increase
R4098 T6466 T6462 dobj increase,saw
R4099 T6467 T6466 prep in,increase
R4100 T6468 T6469 det the,expression
R4101 T6469 T6467 pobj expression,in
R4102 T6470 T6469 prep of,expression
R4103 T6471 T6470 pobj Col1a1,of
R4104 T6472 T6466 prep in,increase
R4105 T6473 T6474 nmod mutant,cartilage
R4106 T6474 T6472 pobj cartilage,in
R4107 T6475 T6474 amod articular,cartilage
R4108 T6476 T6462 punct ", ",saw
R4109 T6477 T6462 cc and,saw
R4110 T6478 T6479 det no,proliferation
R4111 T6479 T6480 nsubjpass proliferation,detected
R4112 T6480 T6462 conj detected,saw
R4113 T6481 T6480 auxpass was,detected
R4114 T6482 T6480 prep in,detected
R4115 T6483 T6484 amod articular,cells
R4116 T6484 T6482 pobj cells,in
R4117 T6485 T6484 prep of,cells
R4118 T6486 T6487 preconj either,mutant
R4119 T6487 T6488 amod mutant,animals
R4120 T6488 T6485 pobj animals,of
R4121 T6489 T6487 cc or,mutant
R4122 T6490 T6487 conj control,mutant
R4123 T6491 T6492 punct (,data
R4124 T6492 T6480 meta data,detected
R4125 T6493 T6492 amod unpublished,data
R4126 T6494 T6492 punct ),data
R4127 T6495 T6480 punct .,detected
R4128 T6497 T6498 mark While,detected
R4129 T6498 T6504 advcl detected,observed
R4130 T6499 T6500 amod recombined,expression
R4131 T6500 T6498 nsubjpass expression,detected
R4132 T6501 T6502 compound LACZ,marker
R4133 T6502 T6500 compound marker,expression
R4134 T6503 T6498 auxpass was,detected
R4135 T6505 T6498 prep in,detected
R4136 T6506 T6507 amod most,cells
R4137 T6507 T6505 pobj cells,in
R4138 T6508 T6509 amod articular,cartilage
R4139 T6509 T6507 compound cartilage,cells
R4140 T6510 T6504 punct ", ",observed
R4141 T6511 T6504 nsubjpass it,observed
R4142 T6512 T6504 auxpass was,observed
R4143 T6513 T6504 advmod also,observed
R4144 T6514 T6504 prep in,observed
R4145 T6515 T6516 amod scattered,chondrocytes
R4146 T6516 T6514 pobj chondrocytes,in
R4147 T6517 T6516 amod subarticular,chondrocytes
R4148 T6518 T6516 punct ", ",chondrocytes
R4149 T6519 T6520 compound growth,plate
R4150 T6520 T6521 compound plate,chondrocytes
R4151 T6521 T6516 conj chondrocytes,chondrocytes
R4152 T6522 T6521 punct ", ",chondrocytes
R4153 T6523 T6521 cc and,chondrocytes
R4154 T6524 T6521 conj osteoblasts,chondrocytes
R4155 T6525 T6526 punct (,Figure
R4156 T6526 T6504 parataxis Figure,observed
R4157 T6527 T6526 nummod 5O,Figure
R4158 T6528 T6526 cc and,Figure
R4159 T6529 T6526 conj 5T,Figure
R4160 T6530 T6526 punct ),Figure
R4161 T6531 T6532 punct (,data
R4162 T6532 T6504 meta data,observed
R4163 T6533 T6532 amod unpublished,data
R4164 T6534 T6532 punct ),data
R4165 T6535 T6504 punct .,observed
R4166 T6537 T6538 mark Although,implies
R4167 T6538 T6540 advcl implies,confined
R4168 T6539 T6538 nsubj this,implies
R4169 T6541 T6542 mark that,was
R4170 T6542 T6538 ccomp was,implies
R4171 T6543 T6544 compound BMP,signaling
R4172 T6544 T6542 nsubj signaling,was
R4173 T6545 T6542 acomp defective,was
R4174 T6546 T6542 prep in,was
R4175 T6547 T6548 amod multiple,types
R4176 T6548 T6546 pobj types,in
R4177 T6549 T6548 compound cell,types
R4178 T6550 T6540 punct ", ",confined
R4179 T6551 T6552 det the,defects
R4180 T6552 T6540 nsubjpass defects,confined
R4181 T6553 T6552 amod observed,defects
R4182 T6554 T6540 auxpass were,confined
R4183 T6555 T6540 prep to,confined
R4184 T6556 T6557 det the,cartilage
R4185 T6557 T6555 pobj cartilage,to
R4186 T6558 T6557 amod articular,cartilage
R4187 T6559 T6540 punct .,confined
R4188 T6561 T6562 prep For,appeared
R4189 T6563 T6561 pobj example,For
R4190 T6564 T6562 punct ", ",appeared
R4191 T6565 T6566 nmod Osteocalcin,expression
R4192 T6566 T6562 nsubj expression,appeared
R4193 T6567 T6565 cc and,Osteocalcin
R4194 T6568 T6565 conj Col1a1,Osteocalcin
R4195 T6569 T6562 oprd normal,appeared
R4196 T6570 T6562 prep in,appeared
R4197 T6571 T6570 pobj osteoblasts,in
R4198 T6572 T6573 punct (,data
R4199 T6573 T6562 meta data,appeared
R4200 T6574 T6573 amod unpublished,data
R4201 T6575 T6573 punct ),data
R4202 T6576 T6562 punct .,appeared
R4203 T6578 T6579 advmod Together,suggest
R4204 T6580 T6579 punct ", ",suggest
R4205 T6581 T6582 det these,data
R4206 T6582 T6579 nsubj data,suggest
R4207 T6583 T6584 mark that,required
R4208 T6584 T6579 ccomp required,suggest
R4209 T6585 T6586 compound BMPR1A,activity
R4210 T6586 T6584 nsubjpass activity,required
R4211 T6587 T6584 auxpass is,required
R4212 T6588 T6584 prep in,required
R4213 T6589 T6590 amod postnatal,cartilage
R4214 T6590 T6588 pobj cartilage,in
R4215 T6591 T6592 npadvmod joint,articular
R4216 T6592 T6590 amod articular,cartilage
R4217 T6593 T6594 aux to,maintain
R4218 T6594 T6584 advcl maintain,required
R4219 T6595 T6594 dobj expression,maintain
R4220 T6596 T6595 prep of,expression
R4221 T6597 T6598 amod many,genes
R4222 T6598 T6596 pobj genes,of
R4223 T6599 T6598 acl encoding,genes
R4224 T6600 T6601 amod structural,components
R4225 T6601 T6599 dobj components,encoding
R4226 T6602 T6601 prep of,components
R4227 T6603 T6604 compound cartilage,matrix
R4228 T6604 T6602 pobj matrix,of
R4229 T6605 T6579 punct .,suggest