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PMC:523229 / 20553-22491 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T4677 0-13 JJ denotes Developmental
T4678 14-20 NN denotes Origin
T4679 21-23 IN denotes of
T4680 24-31 NN denotes Webbing
T4681 32-41 NN denotes Phenotype
T4682 41-358 sentence denotes Interdigital mesenchyme is normally eliminated by apoptosis during embryonic development, a process that can be stimulated by BMP beads, inhibited by Noggin, or blocked by overexpression of dominant-negative BMP receptors (Garcia-Martinez et al. 1993; Yokouchi et al. 1996; Zou and Niswander 1996; Guha et al. 2002).
T4683 42-54 JJ denotes Interdigital
T4684 55-65 NN denotes mesenchyme
T4686 66-68 VBZ denotes is
T4687 69-77 RB denotes normally
T4685 78-88 VBN denotes eliminated
T4688 89-91 IN denotes by
T4689 92-101 NN denotes apoptosis
T4690 102-108 IN denotes during
T4691 109-118 JJ denotes embryonic
T4692 119-130 NN denotes development
T4693 130-132 , denotes ,
T4694 132-133 DT denotes a
T4695 134-141 NN denotes process
T4696 142-146 WDT denotes that
T4698 147-150 MD denotes can
T4699 151-153 VB denotes be
T4697 154-164 VBN denotes stimulated
T4700 165-167 IN denotes by
T4701 168-171 NN denotes BMP
T4702 172-177 NNS denotes beads
T4703 177-179 , denotes ,
T4704 179-188 VBN denotes inhibited
T4705 189-191 IN denotes by
T4706 192-198 NN denotes Noggin
T4707 198-200 , denotes ,
T4708 200-202 CC denotes or
T4709 203-210 VBN denotes blocked
T4710 211-213 IN denotes by
T4711 214-228 NN denotes overexpression
T4712 229-231 IN denotes of
T4713 232-240 JJ denotes dominant
T4715 240-241 HYPH denotes -
T4714 241-249 JJ denotes negative
T4717 250-253 NN denotes BMP
T4716 254-263 NNS denotes receptors
T4718 264-265 -LRB- denotes (
T4719 265-271 NNP denotes Garcia
T4720 271-272 HYPH denotes -
T4721 272-280 NNP denotes Martinez
T4722 281-283 FW denotes et
T4723 284-287 FW denotes al.
T4724 288-292 CD denotes 1993
T4725 292-293 : denotes ;
T4726 294-302 NNP denotes Yokouchi
T4727 303-305 FW denotes et
T4728 306-309 FW denotes al.
T4729 310-314 CD denotes 1996
T4730 314-315 : denotes ;
T4731 316-319 NNP denotes Zou
T4732 320-323 CC denotes and
T4733 324-333 NNP denotes Niswander
T4734 334-338 CD denotes 1996
T4735 338-339 : denotes ;
T4736 340-344 NNP denotes Guha
T4737 345-347 FW denotes et
T4738 348-351 FW denotes al.
T4739 352-356 CD denotes 2002
T4740 356-357 -RRB- denotes )
T4741 357-358 . denotes .
T4742 358-632 sentence denotes Limbs of Gdf5-Cre/Bmpr1afloxP mutant embryos showed obvious retention of interdigital webbing between the first and second, but not other, digits of E14.5 forelimbs (Figure 2A and 2B), a pattern that corresponds to the presence or absence of webbing seen in the adult limb.
T4743 359-364 NNS denotes Limbs
T4745 365-367 IN denotes of
T4746 368-372 NN denotes Gdf5
T4748 372-373 HYPH denotes -
T4747 373-376 NN denotes Cre
T4750 376-377 HYPH denotes /
T4749 377-388 NN denotes Bmpr1afloxP
T4751 389-395 JJ denotes mutant
T4752 396-403 NNS denotes embryos
T4744 404-410 VBD denotes showed
T4753 411-418 JJ denotes obvious
T4754 419-428 NN denotes retention
T4755 429-431 IN denotes of
T4756 432-444 JJ denotes interdigital
T4757 445-452 NN denotes webbing
T4758 453-460 IN denotes between
T4759 461-464 DT denotes the
T4761 465-470 JJ denotes first
T4762 471-474 CC denotes and
T4763 475-481 JJ denotes second
T4764 481-483 , denotes ,
T4765 483-486 CC denotes but
T4766 487-490 RB denotes not
T4767 491-496 JJ denotes other
T4768 496-498 , denotes ,
T4760 498-504 NNS denotes digits
T4769 505-507 IN denotes of
T4770 508-513 NN denotes E14.5
T4771 514-523 NNS denotes forelimbs
T4772 524-525 -LRB- denotes (
T4773 525-531 NN denotes Figure
T4774 532-534 CD denotes 2A
T4775 535-538 CC denotes and
T4776 539-541 CD denotes 2B
T4777 541-542 -RRB- denotes )
T4778 542-544 , denotes ,
T4779 544-545 DT denotes a
T4780 546-553 NN denotes pattern
T4781 554-558 WDT denotes that
T4782 559-570 VBZ denotes corresponds
T4783 571-573 IN denotes to
T4784 574-577 DT denotes the
T4785 578-586 NN denotes presence
T4786 587-589 CC denotes or
T4787 590-597 NN denotes absence
T4788 598-600 IN denotes of
T4789 601-608 NN denotes webbing
T4790 609-613 VBN denotes seen
T4791 614-616 IN denotes in
T4792 617-620 DT denotes the
T4794 621-626 NN denotes adult
T4793 627-631 NN denotes limb
T4795 631-632 . denotes .
T4796 632-726 sentence denotes They also showed excess tissue on the posterior margin of the fifth digit (Figure 2B, arrow).
T4797 633-637 PRP denotes They
T4799 638-642 RB denotes also
T4798 643-649 VBD denotes showed
T4800 650-656 JJ denotes excess
T4801 657-663 NN denotes tissue
T4802 664-666 IN denotes on
T4803 667-670 DT denotes the
T4805 671-680 JJ denotes posterior
T4804 681-687 NN denotes margin
T4806 688-690 IN denotes of
T4807 691-694 DT denotes the
T4809 695-700 JJ denotes fifth
T4808 701-706 NN denotes digit
T4810 707-708 -LRB- denotes (
T4812 708-714 NN denotes Figure
T4813 715-717 CD denotes 2B
T4814 717-719 , denotes ,
T4811 719-724 NN denotes arrow
T4815 724-725 -RRB- denotes )
T4816 725-726 . denotes .
T4817 726-970 sentence denotes Analysis of LACZ expression in Gdf5-Cre/R26R reporter embryos showed that Cre-mediated recombination has occurred by E13.5 in the metacarpal-phalangeal joints, and in the interdigital region between the first and second, but not other, digits.
T4818 727-735 NN denotes Analysis
T4820 736-738 IN denotes of
T4821 739-743 NN denotes LACZ
T4822 744-754 NN denotes expression
T4823 755-757 IN denotes in
T4824 758-762 NN denotes Gdf5
T4826 762-763 HYPH denotes -
T4825 763-766 NN denotes Cre
T4828 766-767 HYPH denotes /
T4827 767-771 NN denotes R26R
T4830 772-780 NN denotes reporter
T4829 781-788 NNS denotes embryos
T4819 789-795 VBD denotes showed
T4831 796-800 IN denotes that
T4833 801-804 NN denotes Cre
T4835 804-805 HYPH denotes -
T4834 805-813 VBN denotes mediated
T4836 814-827 NN denotes recombination
T4837 828-831 VBZ denotes has
T4832 832-840 VBN denotes occurred
T4838 841-843 IN denotes by
T4839 844-849 NN denotes E13.5
T4840 850-852 IN denotes in
T4841 853-856 DT denotes the
T4843 857-867 JJ denotes metacarpal
T4845 867-868 HYPH denotes -
T4844 868-878 JJ denotes phalangeal
T4842 879-885 NNS denotes joints
T4846 885-887 , denotes ,
T4847 887-890 CC denotes and
T4848 891-893 IN denotes in
T4849 894-897 DT denotes the
T4851 898-910 JJ denotes interdigital
T4850 911-917 NN denotes region
T4852 918-925 IN denotes between
T4853 926-929 DT denotes the
T4855 930-935 JJ denotes first
T4856 936-939 CC denotes and
T4857 940-946 JJ denotes second
T4858 946-948 , denotes ,
T4859 948-951 CC denotes but
T4860 952-955 RB denotes not
T4861 956-961 JJ denotes other
T4862 961-963 , denotes ,
T4854 963-969 NNS denotes digits
T4863 969-970 . denotes .
T4864 970-1112 sentence denotes In addition, a domain of recombination and expression of LACZ is also reproducibly seen in the posterior half of the fifth digit (Figure 2C).
T4865 971-973 IN denotes In
T4867 974-982 NN denotes addition
T4868 982-984 , denotes ,
T4869 984-985 DT denotes a
T4870 986-992 NN denotes domain
T4871 993-995 IN denotes of
T4872 996-1009 NN denotes recombination
T4873 1010-1013 CC denotes and
T4874 1014-1024 NN denotes expression
T4875 1025-1027 IN denotes of
T4876 1028-1032 NN denotes LACZ
T4877 1033-1035 VBZ denotes is
T4878 1036-1040 RB denotes also
T4879 1041-1053 RB denotes reproducibly
T4866 1054-1058 VBN denotes seen
T4880 1059-1061 IN denotes in
T4881 1062-1065 DT denotes the
T4883 1066-1075 JJ denotes posterior
T4882 1076-1080 NN denotes half
T4884 1081-1083 IN denotes of
T4885 1084-1087 DT denotes the
T4887 1088-1093 JJ denotes fifth
T4886 1094-1099 NN denotes digit
T4888 1100-1101 -LRB- denotes (
T4889 1101-1107 NN denotes Figure
T4890 1108-1110 CD denotes 2C
T4891 1110-1111 -RRB- denotes )
T4892 1111-1112 . denotes .
T4893 1112-1451 sentence denotes Terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick end labeling (TUNEL) staining of interdigital mesenchyme between the first and second digits (Figure 2D and 2E) and the fifth digit flanking mesenchyme showed a decreased number of dying cells in the regions where excess tissue is retained in the mutant limbs.
T4894 1113-1121 JJ denotes Terminal
T4896 1122-1138 NN denotes deoxynucleotidyl
T4897 1139-1150 NN denotes transferase
T4899 1150-1151 HYPH denotes –
T4898 1151-1159 VBN denotes mediated
T4900 1160-1172 NN denotes deoxyuridine
T4901 1173-1185 NN denotes triphosphate
T4902 1186-1190 NN denotes nick
T4903 1191-1194 NN denotes end
T4895 1195-1203 NN denotes labeling
T4905 1204-1205 -LRB- denotes (
T4906 1205-1210 NN denotes TUNEL
T4907 1210-1211 -RRB- denotes )
T4904 1212-1220 NN denotes staining
T4909 1221-1223 IN denotes of
T4910 1224-1236 JJ denotes interdigital
T4911 1237-1247 NN denotes mesenchyme
T4912 1248-1255 IN denotes between
T4913 1256-1259 DT denotes the
T4915 1260-1265 JJ denotes first
T4916 1266-1269 CC denotes and
T4917 1270-1276 JJ denotes second
T4914 1277-1283 NNS denotes digits
T4918 1284-1285 -LRB- denotes (
T4919 1285-1291 NN denotes Figure
T4920 1292-1294 CD denotes 2D
T4921 1295-1298 CC denotes and
T4922 1299-1301 CD denotes 2E
T4923 1301-1302 -RRB- denotes )
T4924 1303-1306 CC denotes and
T4925 1307-1310 DT denotes the
T4927 1311-1316 JJ denotes fifth
T4926 1317-1322 NN denotes digit
T4928 1323-1331 VBG denotes flanking
T4929 1332-1342 NN denotes mesenchyme
T4908 1343-1349 VBD denotes showed
T4930 1350-1351 DT denotes a
T4932 1352-1361 VBN denotes decreased
T4931 1362-1368 NN denotes number
T4933 1369-1371 IN denotes of
T4934 1372-1377 VBG denotes dying
T4935 1378-1383 NNS denotes cells
T4936 1384-1386 IN denotes in
T4937 1387-1390 DT denotes the
T4938 1391-1398 NNS denotes regions
T4939 1399-1404 WRB denotes where
T4941 1405-1411 JJ denotes excess
T4942 1412-1418 NN denotes tissue
T4943 1419-1421 VBZ denotes is
T4940 1422-1430 VBN denotes retained
T4944 1431-1433 IN denotes in
T4945 1434-1437 DT denotes the
T4947 1438-1444 NN denotes mutant
T4946 1445-1450 NNS denotes limbs
T4948 1450-1451 . denotes .
T4949 1451-1565 sentence denotes Numbers of phosphorylated histone H3-labeled proliferating cells were also elevated in these regions (Figure 2F).
T4950 1452-1459 NNS denotes Numbers
T4952 1460-1462 IN denotes of
T4953 1463-1477 VBN denotes phosphorylated
T4955 1478-1485 NN denotes histone
T4954 1486-1488 NN denotes H3
T4957 1488-1489 HYPH denotes -
T4956 1489-1496 VBN denotes labeled
T4959 1497-1510 VBG denotes proliferating
T4958 1511-1516 NNS denotes cells
T4960 1517-1521 VBD denotes were
T4961 1522-1526 RB denotes also
T4951 1527-1535 VBN denotes elevated
T4962 1536-1538 IN denotes in
T4963 1539-1544 DT denotes these
T4964 1545-1552 NNS denotes regions
T4965 1553-1554 -LRB- denotes (
T4966 1554-1560 NN denotes Figure
T4967 1561-1563 CD denotes 2F
T4968 1563-1564 -RRB- denotes )
T4969 1564-1565 . denotes .
T4970 1565-1724 sentence denotes Most cells found in the webbed region between the first and second digits at E15.5 strongly expressed LACZ in Gdf5-Cre/Bmpr1afloxP mutant embryos (Figure 2H).
T4971 1566-1570 JJS denotes Most
T4972 1571-1576 NNS denotes cells
T4974 1577-1582 VBN denotes found
T4975 1583-1585 IN denotes in
T4976 1586-1589 DT denotes the
T4978 1590-1596 VBN denotes webbed
T4977 1597-1603 NN denotes region
T4979 1604-1611 IN denotes between
T4980 1612-1615 DT denotes the
T4982 1616-1621 JJ denotes first
T4983 1622-1625 CC denotes and
T4984 1626-1632 JJ denotes second
T4981 1633-1639 NNS denotes digits
T4985 1640-1642 IN denotes at
T4986 1643-1648 NN denotes E15.5
T4987 1649-1657 RB denotes strongly
T4973 1658-1667 VBD denotes expressed
T4988 1668-1672 NN denotes LACZ
T4989 1673-1675 IN denotes in
T4990 1676-1680 NN denotes Gdf5
T4992 1680-1681 HYPH denotes -
T4991 1681-1684 NN denotes Cre
T4994 1684-1685 HYPH denotes /
T4993 1685-1696 NN denotes Bmpr1afloxP
T4996 1697-1703 NN denotes mutant
T4995 1704-1711 NNS denotes embryos
T4997 1712-1713 -LRB- denotes (
T4998 1713-1719 NN denotes Figure
T4999 1720-1722 CD denotes 2H
T5000 1722-1723 -RRB- denotes )
T5001 1723-1724 . denotes .
T5002 1724-1938 sentence denotes These data suggest that regional loss of BMPR1A receptor signaling blocks programmed cell death in interdigital mesenchyme, and that the recombined cells survive and proliferate in the absence of BMPR1A signaling.
T5003 1725-1730 DT denotes These
T5004 1731-1735 NNS denotes data
T5005 1736-1743 VBP denotes suggest
T5006 1744-1748 IN denotes that
T5008 1749-1757 JJ denotes regional
T5009 1758-1762 NN denotes loss
T5010 1763-1765 IN denotes of
T5011 1766-1772 NN denotes BMPR1A
T5013 1773-1781 NN denotes receptor
T5012 1782-1791 NN denotes signaling
T5007 1792-1798 VBZ denotes blocks
T5014 1799-1809 VBN denotes programmed
T5016 1810-1814 NN denotes cell
T5015 1815-1820 NN denotes death
T5017 1821-1823 IN denotes in
T5018 1824-1836 JJ denotes interdigital
T5019 1837-1847 NN denotes mesenchyme
T5020 1847-1849 , denotes ,
T5021 1849-1852 CC denotes and
T5022 1853-1857 IN denotes that
T5024 1858-1861 DT denotes the
T5026 1862-1872 VBN denotes recombined
T5025 1873-1878 NNS denotes cells
T5023 1879-1886 VBP denotes survive
T5027 1887-1890 CC denotes and
T5028 1891-1902 VBP denotes proliferate
T5029 1903-1905 IN denotes in
T5030 1906-1909 DT denotes the
T5031 1910-1917 NN denotes absence
T5032 1918-1920 IN denotes of
T5033 1921-1927 NN denotes BMPR1A
T5034 1928-1937 NN denotes signaling
T5035 1937-1938 . denotes .
R2946 T4677 T4678 amod Developmental,Origin
R2947 T4679 T4678 prep of,Origin
R2948 T4680 T4681 compound Webbing,Phenotype
R2949 T4681 T4679 pobj Phenotype,of
R2950 T4683 T4684 amod Interdigital,mesenchyme
R2951 T4684 T4685 nsubjpass mesenchyme,eliminated
R2952 T4686 T4685 auxpass is,eliminated
R2953 T4687 T4685 advmod normally,eliminated
R2954 T4688 T4685 agent by,eliminated
R2955 T4689 T4688 pobj apoptosis,by
R2956 T4690 T4685 prep during,eliminated
R2957 T4691 T4692 amod embryonic,development
R2958 T4692 T4690 pobj development,during
R2959 T4693 T4685 punct ", ",eliminated
R2960 T4694 T4695 det a,process
R2961 T4695 T4685 npadvmod process,eliminated
R2962 T4696 T4697 dep that,stimulated
R2963 T4697 T4695 relcl stimulated,process
R2964 T4698 T4697 aux can,stimulated
R2965 T4699 T4697 auxpass be,stimulated
R2966 T4700 T4697 agent by,stimulated
R2967 T4701 T4702 compound BMP,beads
R2968 T4702 T4700 pobj beads,by
R2969 T4703 T4697 punct ", ",stimulated
R2970 T4704 T4697 conj inhibited,stimulated
R2971 T4705 T4704 agent by,inhibited
R2972 T4706 T4705 pobj Noggin,by
R2973 T4707 T4704 punct ", ",inhibited
R2974 T4708 T4704 cc or,inhibited
R2975 T4709 T4704 conj blocked,inhibited
R2976 T4710 T4709 agent by,blocked
R2977 T4711 T4710 pobj overexpression,by
R2978 T4712 T4711 prep of,overexpression
R2979 T4713 T4714 amod dominant,negative
R2980 T4714 T4716 nmod negative,receptors
R2981 T4715 T4714 punct -,negative
R2982 T4716 T4712 pobj receptors,of
R2983 T4717 T4716 compound BMP,receptors
R2984 T4718 T4719 punct (,Garcia
R2985 T4719 T4685 meta Garcia,eliminated
R2986 T4720 T4719 punct -,Garcia
R2987 T4721 T4719 nmod Martinez,Garcia
R2988 T4722 T4719 nmod et,Garcia
R2989 T4723 T4719 nmod al.,Garcia
R2990 T4724 T4719 nummod 1993,Garcia
R2991 T4725 T4719 punct ;,Garcia
R2992 T4726 T4719 conj Yokouchi,Garcia
R2993 T4727 T4726 nmod et,Yokouchi
R2994 T4728 T4726 nmod al.,Yokouchi
R2995 T4729 T4726 nummod 1996,Yokouchi
R2996 T4730 T4726 punct ;,Yokouchi
R2997 T4731 T4726 conj Zou,Yokouchi
R2998 T4732 T4731 cc and,Zou
R2999 T4733 T4731 conj Niswander,Zou
R3000 T4734 T4733 nummod 1996,Niswander
R3001 T4735 T4733 punct ;,Niswander
R3002 T4736 T4733 conj Guha,Niswander
R3003 T4737 T4736 nmod et,Guha
R3004 T4738 T4736 nmod al.,Guha
R3005 T4739 T4736 nummod 2002,Guha
R3006 T4740 T4736 punct ),Guha
R3007 T4741 T4685 punct .,eliminated
R3008 T4743 T4744 nsubj Limbs,showed
R3009 T4745 T4743 prep of,Limbs
R3010 T4746 T4747 compound Gdf5,Cre
R3011 T4747 T4749 compound Cre,Bmpr1afloxP
R3012 T4748 T4747 punct -,Cre
R3013 T4749 T4751 npadvmod Bmpr1afloxP,mutant
R3014 T4750 T4749 punct /,Bmpr1afloxP
R3015 T4751 T4752 amod mutant,embryos
R3016 T4752 T4745 pobj embryos,of
R3017 T4753 T4754 amod obvious,retention
R3018 T4754 T4744 dobj retention,showed
R3019 T4755 T4754 prep of,retention
R3020 T4756 T4757 amod interdigital,webbing
R3021 T4757 T4755 pobj webbing,of
R3022 T4758 T4757 prep between,webbing
R3023 T4759 T4760 det the,digits
R3024 T4760 T4758 pobj digits,between
R3025 T4761 T4760 amod first,digits
R3026 T4762 T4761 cc and,first
R3027 T4763 T4761 conj second,first
R3028 T4764 T4761 punct ", ",first
R3029 T4765 T4761 cc but,first
R3030 T4766 T4765 neg not,but
R3031 T4767 T4761 conj other,first
R3032 T4768 T4760 punct ", ",digits
R3033 T4769 T4760 prep of,digits
R3034 T4770 T4771 compound E14.5,forelimbs
R3035 T4771 T4769 pobj forelimbs,of
R3036 T4772 T4773 punct (,Figure
R3037 T4773 T4760 parataxis Figure,digits
R3038 T4774 T4773 nummod 2A,Figure
R3039 T4775 T4773 cc and,Figure
R3040 T4776 T4773 conj 2B,Figure
R3041 T4777 T4773 punct ),Figure
R3042 T4778 T4744 punct ", ",showed
R3043 T4779 T4780 det a,pattern
R3044 T4780 T4744 npadvmod pattern,showed
R3045 T4781 T4782 dep that,corresponds
R3046 T4782 T4780 relcl corresponds,pattern
R3047 T4783 T4782 prep to,corresponds
R3048 T4784 T4785 det the,presence
R3049 T4785 T4783 pobj presence,to
R3050 T4786 T4785 cc or,presence
R3051 T4787 T4785 conj absence,presence
R3052 T4788 T4785 prep of,presence
R3053 T4789 T4788 pobj webbing,of
R3054 T4790 T4789 acl seen,webbing
R3055 T4791 T4790 prep in,seen
R3056 T4792 T4793 det the,limb
R3057 T4793 T4791 pobj limb,in
R3058 T4794 T4793 compound adult,limb
R3059 T4795 T4744 punct .,showed
R3060 T4797 T4798 nsubj They,showed
R3061 T4799 T4798 advmod also,showed
R3062 T4800 T4801 amod excess,tissue
R3063 T4801 T4798 dobj tissue,showed
R3064 T4802 T4798 prep on,showed
R3065 T4803 T4804 det the,margin
R3066 T4804 T4802 pobj margin,on
R3067 T4805 T4804 amod posterior,margin
R3068 T4806 T4804 prep of,margin
R3069 T4807 T4808 det the,digit
R3070 T4808 T4806 pobj digit,of
R3071 T4809 T4808 amod fifth,digit
R3072 T4810 T4811 punct (,arrow
R3073 T4811 T4798 parataxis arrow,showed
R3074 T4812 T4811 dep Figure,arrow
R3075 T4813 T4812 nummod 2B,Figure
R3076 T4814 T4811 punct ", ",arrow
R3077 T4815 T4811 punct ),arrow
R3078 T4816 T4798 punct .,showed
R3079 T4818 T4819 nsubj Analysis,showed
R3080 T4820 T4818 prep of,Analysis
R3081 T4821 T4822 compound LACZ,expression
R3082 T4822 T4820 pobj expression,of
R3083 T4823 T4818 prep in,Analysis
R3084 T4824 T4825 compound Gdf5,Cre
R3085 T4825 T4827 compound Cre,R26R
R3086 T4826 T4825 punct -,Cre
R3087 T4827 T4829 compound R26R,embryos
R3088 T4828 T4827 punct /,R26R
R3089 T4829 T4823 pobj embryos,in
R3090 T4830 T4829 compound reporter,embryos
R3091 T4831 T4832 mark that,occurred
R3092 T4832 T4819 ccomp occurred,showed
R3093 T4833 T4834 npadvmod Cre,mediated
R3094 T4834 T4836 amod mediated,recombination
R3095 T4835 T4834 punct -,mediated
R3096 T4836 T4832 nsubj recombination,occurred
R3097 T4837 T4832 aux has,occurred
R3098 T4838 T4832 prep by,occurred
R3099 T4839 T4838 pobj E13.5,by
R3100 T4840 T4832 prep in,occurred
R3101 T4841 T4842 det the,joints
R3102 T4842 T4840 pobj joints,in
R3103 T4843 T4844 amod metacarpal,phalangeal
R3104 T4844 T4842 amod phalangeal,joints
R3105 T4845 T4844 punct -,phalangeal
R3106 T4846 T4840 punct ", ",in
R3107 T4847 T4840 cc and,in
R3108 T4848 T4840 conj in,in
R3109 T4849 T4850 det the,region
R3110 T4850 T4848 pobj region,in
R3111 T4851 T4850 amod interdigital,region
R3112 T4852 T4850 prep between,region
R3113 T4853 T4854 det the,digits
R3114 T4854 T4852 pobj digits,between
R3115 T4855 T4854 amod first,digits
R3116 T4856 T4855 cc and,first
R3117 T4857 T4855 conj second,first
R3118 T4858 T4855 punct ", ",first
R3119 T4859 T4855 cc but,first
R3120 T4860 T4859 neg not,but
R3121 T4861 T4855 conj other,first
R3122 T4862 T4854 punct ", ",digits
R3123 T4863 T4819 punct .,showed
R3124 T4865 T4866 prep In,seen
R3125 T4867 T4865 pobj addition,In
R3126 T4868 T4866 punct ", ",seen
R3127 T4869 T4870 det a,domain
R3128 T4870 T4866 nsubjpass domain,seen
R3129 T4871 T4870 prep of,domain
R3130 T4872 T4871 pobj recombination,of
R3131 T4873 T4872 cc and,recombination
R3132 T4874 T4872 conj expression,recombination
R3133 T4875 T4872 prep of,recombination
R3134 T4876 T4875 pobj LACZ,of
R3135 T4877 T4866 auxpass is,seen
R3136 T4878 T4866 advmod also,seen
R3137 T4879 T4866 advmod reproducibly,seen
R3138 T4880 T4866 prep in,seen
R3139 T4881 T4882 det the,half
R3140 T4882 T4880 pobj half,in
R3141 T4883 T4882 amod posterior,half
R3142 T4884 T4882 prep of,half
R3143 T4885 T4886 det the,digit
R3144 T4886 T4884 pobj digit,of
R3145 T4887 T4886 amod fifth,digit
R3146 T4888 T4889 punct (,Figure
R3147 T4889 T4866 parataxis Figure,seen
R3148 T4890 T4889 nummod 2C,Figure
R3149 T4891 T4889 punct ),Figure
R3150 T4892 T4866 punct .,seen
R3151 T4894 T4895 amod Terminal,labeling
R3152 T4895 T4904 nmod labeling,staining
R3153 T4896 T4897 compound deoxynucleotidyl,transferase
R3154 T4897 T4898 npadvmod transferase,mediated
R3155 T4898 T4895 amod mediated,labeling
R3156 T4899 T4898 punct –,mediated
R3157 T4900 T4901 nmod deoxyuridine,triphosphate
R3158 T4901 T4895 nmod triphosphate,labeling
R3159 T4902 T4903 nmod nick,end
R3160 T4903 T4895 nmod end,labeling
R3161 T4904 T4908 nsubj staining,showed
R3162 T4905 T4906 punct (,TUNEL
R3163 T4906 T4895 appos TUNEL,labeling
R3164 T4907 T4906 punct ),TUNEL
R3165 T4909 T4904 prep of,staining
R3166 T4910 T4911 amod interdigital,mesenchyme
R3167 T4911 T4909 pobj mesenchyme,of
R3168 T4912 T4911 prep between,mesenchyme
R3169 T4913 T4914 det the,digits
R3170 T4914 T4912 pobj digits,between
R3171 T4915 T4914 amod first,digits
R3172 T4916 T4915 cc and,first
R3173 T4917 T4915 conj second,first
R3174 T4918 T4919 punct (,Figure
R3175 T4919 T4914 parataxis Figure,digits
R3176 T4920 T4919 nummod 2D,Figure
R3177 T4921 T4919 cc and,Figure
R3178 T4922 T4919 conj 2E,Figure
R3179 T4923 T4919 punct ),Figure
R3180 T4924 T4914 cc and,digits
R3181 T4925 T4926 det the,digit
R3182 T4926 T4914 conj digit,digits
R3183 T4927 T4926 amod fifth,digit
R3184 T4928 T4914 acl flanking,digits
R3185 T4929 T4928 dobj mesenchyme,flanking
R3186 T4930 T4931 det a,number
R3187 T4931 T4908 dobj number,showed
R3188 T4932 T4931 amod decreased,number
R3189 T4933 T4931 prep of,number
R3190 T4934 T4935 amod dying,cells
R3191 T4935 T4933 pobj cells,of
R3192 T4936 T4908 prep in,showed
R3193 T4937 T4938 det the,regions
R3194 T4938 T4936 pobj regions,in
R3195 T4939 T4940 advmod where,retained
R3196 T4940 T4938 relcl retained,regions
R3197 T4941 T4942 amod excess,tissue
R3198 T4942 T4940 nsubjpass tissue,retained
R3199 T4943 T4940 auxpass is,retained
R3200 T4944 T4940 prep in,retained
R3201 T4945 T4946 det the,limbs
R3202 T4946 T4944 pobj limbs,in
R3203 T4947 T4946 compound mutant,limbs
R3204 T4948 T4908 punct .,showed
R3205 T4950 T4951 nsubjpass Numbers,elevated
R3206 T4952 T4950 prep of,Numbers
R3207 T4953 T4954 amod phosphorylated,H3
R3208 T4954 T4956 npadvmod H3,labeled
R3209 T4955 T4954 compound histone,H3
R3210 T4956 T4958 amod labeled,cells
R3211 T4957 T4956 punct -,labeled
R3212 T4958 T4952 pobj cells,of
R3213 T4959 T4958 amod proliferating,cells
R3214 T4960 T4951 auxpass were,elevated
R3215 T4961 T4951 advmod also,elevated
R3216 T4962 T4951 prep in,elevated
R3217 T4963 T4964 det these,regions
R3218 T4964 T4962 pobj regions,in
R3219 T4965 T4966 punct (,Figure
R3220 T4966 T4951 parataxis Figure,elevated
R3221 T4967 T4966 nummod 2F,Figure
R3222 T4968 T4966 punct ),Figure
R3223 T4969 T4951 punct .,elevated
R3224 T4971 T4972 amod Most,cells
R3225 T4972 T4973 nsubj cells,expressed
R3226 T4974 T4972 acl found,cells
R3227 T4975 T4974 prep in,found
R3228 T4976 T4977 det the,region
R3229 T4977 T4975 pobj region,in
R3230 T4978 T4977 amod webbed,region
R3231 T4979 T4977 prep between,region
R3232 T4980 T4981 det the,digits
R3233 T4981 T4979 pobj digits,between
R3234 T4982 T4981 amod first,digits
R3235 T4983 T4982 cc and,first
R3236 T4984 T4982 conj second,first
R3237 T4985 T4974 prep at,found
R3238 T4986 T4985 pobj E15.5,at
R3239 T4987 T4973 advmod strongly,expressed
R3240 T4988 T4973 dobj LACZ,expressed
R3241 T4989 T4973 prep in,expressed
R3242 T4990 T4991 compound Gdf5,Cre
R3243 T4991 T4993 compound Cre,Bmpr1afloxP
R3244 T4992 T4991 punct -,Cre
R3245 T4993 T4995 compound Bmpr1afloxP,embryos
R3246 T4994 T4993 punct /,Bmpr1afloxP
R3247 T4995 T4989 pobj embryos,in
R3248 T4996 T4995 compound mutant,embryos
R3249 T4997 T4998 punct (,Figure
R3250 T4998 T4973 parataxis Figure,expressed
R3251 T4999 T4998 nummod 2H,Figure
R3252 T5000 T4998 punct ),Figure
R3253 T5001 T4973 punct .,expressed
R3254 T5003 T5004 det These,data
R3255 T5004 T5005 nsubj data,suggest
R3256 T5006 T5007 mark that,blocks
R3257 T5007 T5005 advcl blocks,suggest
R3258 T5008 T5009 amod regional,loss
R3259 T5009 T5007 nsubj loss,blocks
R3260 T5010 T5009 prep of,loss
R3261 T5011 T5012 compound BMPR1A,signaling
R3262 T5012 T5010 pobj signaling,of
R3263 T5013 T5012 compound receptor,signaling
R3264 T5014 T5015 amod programmed,death
R3265 T5015 T5007 dobj death,blocks
R3266 T5016 T5015 compound cell,death
R3267 T5017 T5007 prep in,blocks
R3268 T5018 T5019 amod interdigital,mesenchyme
R3269 T5019 T5017 pobj mesenchyme,in
R3270 T5020 T5007 punct ", ",blocks
R3271 T5021 T5007 cc and,blocks
R3272 T5022 T5023 mark that,survive
R3273 T5023 T5007 conj survive,blocks
R3274 T5024 T5025 det the,cells
R3275 T5025 T5023 nsubj cells,survive
R3276 T5026 T5025 amod recombined,cells
R3277 T5027 T5023 cc and,survive
R3278 T5028 T5023 conj proliferate,survive
R3279 T5029 T5028 prep in,proliferate
R3280 T5030 T5031 det the,absence
R3281 T5031 T5029 pobj absence,in
R3282 T5032 T5031 prep of,absence
R3283 T5033 T5034 compound BMPR1A,signaling
R3284 T5034 T5032 pobj signaling,of
R3285 T5035 T5005 punct .,suggest