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PMC:523229 / 11850-13980 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2982 0-3 NN denotes GAC
T2984 3-4 -LRB- denotes (
T2983 4-5 NN denotes A
T2986 5-6 -RRB- denotes )
T2985 7-11 NNS denotes mice
T2988 12-16 VBD denotes were
T2987 17-24 VBN denotes crossed
T2989 25-29 IN denotes with
T2990 30-34 NN denotes lacZ
T2992 35-41 NN denotes ROSA26
T2991 42-45 NN denotes Cre
T2993 46-54 NN denotes reporter
T2994 55-61 NN denotes strain
T2996 62-63 -LRB- denotes (
T2997 63-67 NN denotes R26R
T2998 67-68 -RRB- denotes )
T2995 69-73 NNS denotes mice
T2999 74-76 TO denotes to
T3000 77-84 VB denotes analyze
T3001 85-88 DT denotes the
T3002 89-96 NN denotes pattern
T3003 97-99 IN denotes of
T3004 100-103 NN denotes Cre
T3006 103-104 HYPH denotes -
T3005 104-112 VBN denotes mediated
T3008 113-117 NN denotes lacZ
T3007 118-131 NN denotes recombination
T3009 132-142 IN denotes throughout
T3010 143-154 NN denotes development
T3011 154-155 . denotes .
T3012 155-286 sentence denotes Joints in developing limbs begin forming in a proximal-distal pattern such that the shoulder joint forms prior to the elbow joint.
T3013 156-162 NNS denotes Joints
T3015 163-165 IN denotes in
T3016 166-176 VBG denotes developing
T3017 177-182 NNS denotes limbs
T3014 183-188 VBP denotes begin
T3018 189-196 VBG denotes forming
T3019 197-199 IN denotes in
T3020 200-201 DT denotes a
T3022 202-210 JJ denotes proximal
T3024 210-211 HYPH denotes -
T3023 211-217 JJ denotes distal
T3021 218-225 NN denotes pattern
T3025 226-230 JJ denotes such
T3027 231-235 IN denotes that
T3028 236-239 DT denotes the
T3030 240-248 NN denotes shoulder
T3029 249-254 NN denotes joint
T3026 255-260 VBZ denotes forms
T3031 261-266 RB denotes prior
T3032 267-269 IN denotes to
T3033 270-273 DT denotes the
T3035 274-279 NN denotes elbow
T3034 280-285 NN denotes joint
T3036 285-286 . denotes .
T3037 286-477 sentence denotes In addition, three major stages of early joint development have been defined by histology as (1) interzone formation, (2) three-layer interzone formation, and (3) cavitation (Mitrovic 1978).
T3038 287-289 IN denotes In
T3040 290-298 NN denotes addition
T3041 298-300 , denotes ,
T3042 300-305 CD denotes three
T3044 306-311 JJ denotes major
T3043 312-318 NNS denotes stages
T3045 319-321 IN denotes of
T3046 322-327 JJ denotes early
T3048 328-333 NN denotes joint
T3047 334-345 NN denotes development
T3049 346-350 VBP denotes have
T3050 351-355 VBN denotes been
T3039 356-363 VBN denotes defined
T3051 364-366 IN denotes by
T3052 367-376 NN denotes histology
T3053 377-379 IN denotes as
T3054 380-381 -LRB- denotes (
T3055 381-382 LS denotes 1
T3057 382-383 -RRB- denotes )
T3058 384-393 NN denotes interzone
T3056 394-403 NN denotes formation
T3059 403-405 , denotes ,
T3060 405-406 -LRB- denotes (
T3061 406-407 LS denotes 2
T3063 407-408 -RRB- denotes )
T3064 409-414 CD denotes three
T3066 414-415 HYPH denotes -
T3065 415-420 NN denotes layer
T3067 421-430 NN denotes interzone
T3062 431-440 NN denotes formation
T3068 440-442 , denotes ,
T3069 442-445 CC denotes and
T3070 446-447 -LRB- denotes (
T3071 447-448 LS denotes 3
T3073 448-449 -RRB- denotes )
T3072 450-460 NN denotes cavitation
T3074 461-462 -LRB- denotes (
T3075 462-470 NNP denotes Mitrovic
T3076 471-475 CD denotes 1978
T3077 475-476 -RRB- denotes )
T3078 476-477 . denotes .
T3079 477-689 sentence denotes Consistent with the proximal-distal pattern of joint development in the limbs, LACZ activity is seen at embryonic day 12.5 (E12.5) in the more proximal joints, including the shoulder and knee (unpublished data).
T3080 478-488 JJ denotes Consistent
T3082 489-493 IN denotes with
T3083 494-497 DT denotes the
T3085 498-506 JJ denotes proximal
T3087 506-507 HYPH denotes -
T3086 507-513 JJ denotes distal
T3084 514-521 NN denotes pattern
T3088 522-524 IN denotes of
T3089 525-530 NN denotes joint
T3090 531-542 NN denotes development
T3091 543-545 IN denotes in
T3092 546-549 DT denotes the
T3093 550-555 NNS denotes limbs
T3094 555-557 , denotes ,
T3095 557-561 NN denotes LACZ
T3096 562-570 NN denotes activity
T3097 571-573 VBZ denotes is
T3081 574-578 VBN denotes seen
T3098 579-581 IN denotes at
T3099 582-591 JJ denotes embryonic
T3100 592-595 NN denotes day
T3101 596-600 CD denotes 12.5
T3102 601-602 -LRB- denotes (
T3103 602-607 NN denotes E12.5
T3104 607-608 -RRB- denotes )
T3105 609-611 IN denotes in
T3106 612-615 DT denotes the
T3108 616-620 RBR denotes more
T3109 621-629 JJ denotes proximal
T3107 630-636 NNS denotes joints
T3110 636-638 , denotes ,
T3111 638-647 VBG denotes including
T3112 648-651 DT denotes the
T3113 652-660 NN denotes shoulder
T3114 661-664 CC denotes and
T3115 665-669 NN denotes knee
T3116 670-671 -LRB- denotes (
T3118 671-682 JJ denotes unpublished
T3117 683-687 NNS denotes data
T3119 687-688 -RRB- denotes )
T3120 688-689 . denotes .
T3121 689-891 sentence denotes By E14.5, LACZ expression is typically seen in all but the most distal joints of the limbs (Figure 1B and 1C), but with some variability in both strength and extent of expression from embryo to embryo.
T3122 690-692 IN denotes By
T3124 693-698 NN denotes E14.5
T3125 698-700 , denotes ,
T3126 700-704 NN denotes LACZ
T3127 705-715 NN denotes expression
T3128 716-718 VBZ denotes is
T3129 719-728 RB denotes typically
T3123 729-733 VBN denotes seen
T3130 734-736 IN denotes in
T3131 737-740 DT denotes all
T3132 741-744 IN denotes but
T3133 745-748 DT denotes the
T3135 749-753 RBS denotes most
T3136 754-760 JJ denotes distal
T3134 761-767 NNS denotes joints
T3137 768-770 IN denotes of
T3138 771-774 DT denotes the
T3139 775-780 NNS denotes limbs
T3140 781-782 -LRB- denotes (
T3142 782-788 NN denotes Figure
T3141 789-791 CD denotes 1B
T3143 792-795 CC denotes and
T3144 796-798 CD denotes 1C
T3145 798-799 -RRB- denotes )
T3146 799-801 , denotes ,
T3147 801-804 CC denotes but
T3148 805-809 IN denotes with
T3149 810-814 DT denotes some
T3150 815-826 NN denotes variability
T3151 827-829 IN denotes in
T3152 830-834 CC denotes both
T3153 835-843 NN denotes strength
T3154 844-847 CC denotes and
T3155 848-854 NN denotes extent
T3156 855-857 IN denotes of
T3157 858-868 NN denotes expression
T3158 869-873 IN denotes from
T3159 874-880 NN denotes embryo
T3160 881-883 IN denotes to
T3161 884-890 NN denotes embryo
T3162 890-891 . denotes .
T3163 891-1074 sentence denotes The strongest-staining embryos often have additional staining in fingertips (not seen in the E14.5 embryo in Figure 1C, but clearly detectable in the E13.5 embryo shown in Figure 2).
T3164 892-895 DT denotes The
T3166 896-905 RBS denotes strongest
T3168 905-906 HYPH denotes -
T3167 906-914 VBG denotes staining
T3165 915-922 NNS denotes embryos
T3170 923-928 RB denotes often
T3169 929-933 VBP denotes have
T3171 934-944 JJ denotes additional
T3172 945-953 NN denotes staining
T3173 954-956 IN denotes in
T3174 957-967 NNS denotes fingertips
T3175 968-969 -LRB- denotes (
T3177 969-972 RB denotes not
T3176 973-977 VBN denotes seen
T3178 978-980 IN denotes in
T3179 981-984 DT denotes the
T3181 985-990 NN denotes E14.5
T3180 991-997 NN denotes embryo
T3182 998-1000 IN denotes in
T3183 1001-1007 NN denotes Figure
T3184 1008-1010 CD denotes 1C
T3185 1010-1012 , denotes ,
T3186 1012-1015 CC denotes but
T3187 1016-1023 RB denotes clearly
T3188 1024-1034 JJ denotes detectable
T3189 1035-1037 IN denotes in
T3190 1038-1041 DT denotes the
T3192 1042-1047 NN denotes E13.5
T3191 1048-1054 NN denotes embryo
T3193 1055-1060 VBN denotes shown
T3194 1061-1063 IN denotes in
T3195 1064-1070 NN denotes Figure
T3196 1071-1072 CD denotes 2
T3197 1072-1073 -RRB- denotes )
T3198 1073-1074 . denotes .
T3199 1074-1192 sentence denotes Sections through developing joints show that LACZ is present in many cells at the interzone stage (unpublished data).
T3200 1075-1083 NNS denotes Sections
T3202 1084-1091 IN denotes through
T3203 1092-1102 VBG denotes developing
T3204 1103-1109 NNS denotes joints
T3201 1110-1114 VBP denotes show
T3205 1115-1119 IN denotes that
T3207 1120-1124 NN denotes LACZ
T3206 1125-1127 VBZ denotes is
T3208 1128-1135 JJ denotes present
T3209 1136-1138 IN denotes in
T3210 1139-1143 JJ denotes many
T3211 1144-1149 NNS denotes cells
T3212 1150-1152 IN denotes at
T3213 1153-1156 DT denotes the
T3215 1157-1166 NN denotes interzone
T3214 1167-1172 NN denotes stage
T3216 1173-1174 -LRB- denotes (
T3218 1174-1185 JJ denotes unpublished
T3217 1186-1190 NNS denotes data
T3219 1190-1191 -RRB- denotes )
T3220 1191-1192 . denotes .
T3221 1192-1409 sentence denotes However, expression of LACZ in nearly 100% of joint cells is not achieved until the three-layer interzone stage (for example, in the knee joint at E14.5 or in any of the phalangeal joints at E16.5 (unpublished data).
T3222 1193-1200 RB denotes However
T3224 1200-1202 , denotes ,
T3225 1202-1212 NN denotes expression
T3226 1213-1215 IN denotes of
T3227 1216-1220 NN denotes LACZ
T3228 1221-1223 IN denotes in
T3229 1224-1230 RB denotes nearly
T3230 1231-1234 CD denotes 100
T3231 1234-1235 NN denotes %
T3232 1236-1238 IN denotes of
T3233 1239-1244 NN denotes joint
T3234 1245-1250 NNS denotes cells
T3235 1251-1253 VBZ denotes is
T3236 1254-1257 RB denotes not
T3223 1258-1266 VBN denotes achieved
T3237 1267-1272 IN denotes until
T3238 1273-1276 DT denotes the
T3240 1277-1282 CD denotes three
T3242 1282-1283 HYPH denotes -
T3241 1283-1288 NN denotes layer
T3243 1289-1298 NN denotes interzone
T3239 1299-1304 NN denotes stage
T3244 1305-1306 -LRB- denotes (
T3245 1306-1309 IN denotes for
T3246 1310-1317 NN denotes example
T3247 1317-1319 , denotes ,
T3248 1319-1321 IN denotes in
T3249 1322-1325 DT denotes the
T3251 1326-1330 NN denotes knee
T3250 1331-1336 NN denotes joint
T3252 1337-1339 IN denotes at
T3253 1340-1345 NN denotes E14.5
T3254 1346-1348 CC denotes or
T3255 1349-1351 IN denotes in
T3256 1352-1355 DT denotes any
T3257 1356-1358 IN denotes of
T3258 1359-1362 DT denotes the
T3260 1363-1373 JJ denotes phalangeal
T3259 1374-1380 NNS denotes joints
T3261 1381-1383 IN denotes at
T3262 1384-1389 NN denotes E16.5
T3263 1390-1391 -LRB- denotes (
T3265 1391-1402 JJ denotes unpublished
T3264 1403-1407 NNS denotes data
T3266 1407-1408 -RRB- denotes )
T3267 1408-1409 . denotes .
T3268 1409-1535 sentence denotes Within the developing skeleton, Cre-mediated expression of LACZ remains strikingly specific to joints throughout development.
T3269 1410-1416 IN denotes Within
T3271 1417-1420 DT denotes the
T3273 1421-1431 VBG denotes developing
T3272 1432-1440 NN denotes skeleton
T3274 1440-1442 , denotes ,
T3275 1442-1445 NN denotes Cre
T3277 1445-1446 HYPH denotes -
T3276 1446-1454 VBN denotes mediated
T3278 1455-1465 NN denotes expression
T3279 1466-1468 IN denotes of
T3280 1469-1473 NN denotes LACZ
T3270 1474-1481 VBZ denotes remains
T3281 1482-1492 RB denotes strikingly
T3282 1493-1501 JJ denotes specific
T3283 1502-1504 IN denotes to
T3284 1505-1511 NNS denotes joints
T3285 1512-1522 IN denotes throughout
T3286 1523-1534 NN denotes development
T3287 1534-1535 . denotes .
T3288 1535-1721 sentence denotes Furthermore, it is seen in all the structures of postnatal synovial joints including the articular cartilage, joint capsule, and synovial membrane (Figure 1D and 1E) (unpublished data).
T3289 1536-1547 RB denotes Furthermore
T3291 1547-1549 , denotes ,
T3292 1549-1551 PRP denotes it
T3293 1552-1554 VBZ denotes is
T3290 1555-1559 VBN denotes seen
T3294 1560-1562 IN denotes in
T3295 1563-1566 PDT denotes all
T3297 1567-1570 DT denotes the
T3296 1571-1581 NNS denotes structures
T3298 1582-1584 IN denotes of
T3299 1585-1594 JJ denotes postnatal
T3301 1595-1603 JJ denotes synovial
T3300 1604-1610 NNS denotes joints
T3302 1611-1620 VBG denotes including
T3303 1621-1624 DT denotes the
T3305 1625-1634 JJ denotes articular
T3304 1635-1644 NN denotes cartilage
T3306 1644-1646 , denotes ,
T3307 1646-1651 NN denotes joint
T3308 1652-1659 NN denotes capsule
T3309 1659-1661 , denotes ,
T3310 1661-1664 CC denotes and
T3311 1665-1673 JJ denotes synovial
T3312 1674-1682 NN denotes membrane
T3313 1683-1684 -LRB- denotes (
T3314 1684-1690 NN denotes Figure
T3315 1691-1693 CD denotes 1D
T3316 1694-1697 CC denotes and
T3317 1698-1700 CD denotes 1E
T3318 1700-1701 -RRB- denotes )
T3319 1702-1703 -LRB- denotes (
T3321 1703-1714 JJ denotes unpublished
T3320 1715-1719 NNS denotes data
T3322 1719-1720 -RRB- denotes )
T3323 1720-1721 . denotes .
T3324 1721-1873 sentence denotes These patterns are consistent with the well-established expression of Gdf5 in interzone regions during embryonic development (Storm and Kingsley 1996).
T3325 1722-1727 DT denotes These
T3326 1728-1736 NNS denotes patterns
T3327 1737-1740 VBP denotes are
T3328 1741-1751 JJ denotes consistent
T3329 1752-1756 IN denotes with
T3330 1757-1760 DT denotes the
T3332 1761-1765 RB denotes well
T3334 1765-1766 HYPH denotes -
T3333 1766-1777 VBN denotes established
T3331 1778-1788 NN denotes expression
T3335 1789-1791 IN denotes of
T3336 1792-1796 NN denotes Gdf5
T3337 1797-1799 IN denotes in
T3338 1800-1809 NN denotes interzone
T3339 1810-1817 NNS denotes regions
T3340 1818-1824 IN denotes during
T3341 1825-1834 JJ denotes embryonic
T3342 1835-1846 NN denotes development
T3343 1847-1848 -LRB- denotes (
T3344 1848-1853 NNP denotes Storm
T3345 1854-1857 CC denotes and
T3346 1858-1866 NNP denotes Kingsley
T3347 1867-1871 CD denotes 1996
T3348 1871-1872 -RRB- denotes )
T3349 1872-1873 . denotes .
T3350 1873-2130 sentence denotes Adult expression patterns of the Gdf5 gene are not as well characterized, but Gdf5 expression has previously been detected in adult articular cartilage using both RT-PCR and immunocytochemistry (Chang et al. 1994; Erlacher et al. 1998; Bobacz et al. 2002).
T3351 1874-1879 NN denotes Adult
T3353 1880-1890 NN denotes expression
T3352 1891-1899 NNS denotes patterns
T3355 1900-1902 IN denotes of
T3356 1903-1906 DT denotes the
T3358 1907-1911 NN denotes Gdf5
T3357 1912-1916 NN denotes gene
T3354 1917-1920 VBP denotes are
T3359 1921-1924 RB denotes not
T3360 1925-1927 RB denotes as
T3362 1928-1932 RB denotes well
T3361 1933-1946 VBN denotes characterized
T3363 1946-1948 , denotes ,
T3364 1948-1951 CC denotes but
T3365 1952-1956 NN denotes Gdf5
T3366 1957-1967 NN denotes expression
T3368 1968-1971 VBZ denotes has
T3369 1972-1982 RB denotes previously
T3370 1983-1987 VBN denotes been
T3367 1988-1996 VBN denotes detected
T3371 1997-1999 IN denotes in
T3372 2000-2005 NN denotes adult
T3374 2006-2015 JJ denotes articular
T3373 2016-2025 NN denotes cartilage
T3375 2026-2031 VBG denotes using
T3376 2032-2036 CC denotes both
T3378 2037-2039 NN denotes RT
T3379 2039-2040 HYPH denotes -
T3377 2040-2043 NN denotes PCR
T3380 2044-2047 CC denotes and
T3381 2048-2067 NN denotes immunocytochemistry
T3382 2068-2069 -LRB- denotes (
T3383 2069-2074 NNP denotes Chang
T3384 2075-2077 FW denotes et
T3385 2078-2081 FW denotes al.
T3386 2082-2086 CD denotes 1994
T3387 2086-2087 : denotes ;
T3388 2088-2096 NNP denotes Erlacher
T3389 2097-2099 FW denotes et
T3390 2100-2103 FW denotes al.
T3391 2104-2108 CD denotes 1998
T3392 2108-2109 : denotes ;
T3393 2110-2116 NNP denotes Bobacz
T3394 2117-2119 FW denotes et
T3395 2120-2123 FW denotes al.
T3396 2124-2128 CD denotes 2002
T3397 2128-2129 -RRB- denotes )
T3398 2129-2130 . denotes .
R1707 T2982 T2983 nmod GAC,A
R1708 T2983 T2985 nmod A,mice
R1709 T2984 T2983 punct (,A
R1710 T2985 T2987 nsubjpass mice,crossed
R1711 T2986 T2983 punct ),A
R1712 T2988 T2987 auxpass were,crossed
R1713 T2989 T2987 prep with,crossed
R1714 T2990 T2991 nmod lacZ,Cre
R1715 T2991 T2993 nmod Cre,reporter
R1716 T2992 T2991 nmod ROSA26,Cre
R1717 T2993 T2994 nmod reporter,strain
R1718 T2994 T2995 nmod strain,mice
R1719 T2995 T2989 pobj mice,with
R1720 T2996 T2997 punct (,R26R
R1721 T2997 T2994 appos R26R,strain
R1722 T2998 T2997 punct ),R26R
R1723 T2999 T3000 aux to,analyze
R1724 T3000 T2987 advcl analyze,crossed
R1725 T3001 T3002 det the,pattern
R1726 T3002 T3000 dobj pattern,analyze
R1727 T3003 T3002 prep of,pattern
R1728 T3004 T3005 npadvmod Cre,mediated
R1729 T3005 T3007 amod mediated,recombination
R1730 T3006 T3005 punct -,mediated
R1731 T3007 T3003 pobj recombination,of
R1732 T3008 T3007 compound lacZ,recombination
R1733 T3009 T3000 prep throughout,analyze
R1734 T3010 T3009 pobj development,throughout
R1735 T3011 T2987 punct .,crossed
R1736 T3013 T3014 nsubj Joints,begin
R1737 T3015 T3013 prep in,Joints
R1738 T3016 T3017 amod developing,limbs
R1739 T3017 T3015 pobj limbs,in
R1740 T3018 T3014 xcomp forming,begin
R1741 T3019 T3018 prep in,forming
R1742 T3020 T3021 det a,pattern
R1743 T3021 T3019 pobj pattern,in
R1744 T3022 T3023 amod proximal,distal
R1745 T3023 T3021 amod distal,pattern
R1746 T3024 T3023 punct -,distal
R1747 T3025 T3026 amod such,forms
R1748 T3026 T3018 advcl forms,forming
R1749 T3027 T3026 mark that,forms
R1750 T3028 T3029 det the,joint
R1751 T3029 T3026 nsubj joint,forms
R1752 T3030 T3029 compound shoulder,joint
R1753 T3031 T3026 advmod prior,forms
R1754 T3032 T3031 prep to,prior
R1755 T3033 T3034 det the,joint
R1756 T3034 T3032 pobj joint,to
R1757 T3035 T3034 compound elbow,joint
R1758 T3036 T3014 punct .,begin
R1759 T3038 T3039 prep In,defined
R1760 T3040 T3038 pobj addition,In
R1761 T3041 T3039 punct ", ",defined
R1762 T3042 T3043 nummod three,stages
R1763 T3043 T3039 nsubjpass stages,defined
R1764 T3044 T3043 amod major,stages
R1765 T3045 T3043 prep of,stages
R1766 T3046 T3047 amod early,development
R1767 T3047 T3045 pobj development,of
R1768 T3048 T3047 compound joint,development
R1769 T3049 T3039 aux have,defined
R1770 T3050 T3039 auxpass been,defined
R1771 T3051 T3039 agent by,defined
R1772 T3052 T3051 pobj histology,by
R1773 T3053 T3039 prep as,defined
R1774 T3054 T3055 punct (,1
R1775 T3055 T3056 meta 1,formation
R1776 T3056 T3053 pobj formation,as
R1777 T3057 T3055 punct ),1
R1778 T3058 T3056 compound interzone,formation
R1779 T3059 T3056 punct ", ",formation
R1780 T3060 T3061 punct (,2
R1781 T3061 T3062 meta 2,formation
R1782 T3062 T3056 conj formation,formation
R1783 T3063 T3061 punct ),2
R1784 T3064 T3065 nummod three,layer
R1785 T3065 T3062 compound layer,formation
R1786 T3066 T3065 punct -,layer
R1787 T3067 T3062 compound interzone,formation
R1788 T3068 T3062 punct ", ",formation
R1789 T3069 T3062 cc and,formation
R1790 T3070 T3071 punct (,3
R1791 T3071 T3072 meta 3,cavitation
R1792 T3072 T3062 conj cavitation,formation
R1793 T3073 T3071 punct ),3
R1794 T3074 T3075 punct (,Mitrovic
R1795 T3075 T3039 meta Mitrovic,defined
R1796 T3076 T3075 nummod 1978,Mitrovic
R1797 T3077 T3075 punct ),Mitrovic
R1798 T3078 T3039 punct .,defined
R1799 T3080 T3081 advcl Consistent,seen
R1800 T3082 T3080 prep with,Consistent
R1801 T3083 T3084 det the,pattern
R1802 T3084 T3082 pobj pattern,with
R1803 T3085 T3086 amod proximal,distal
R1804 T3086 T3084 amod distal,pattern
R1805 T3087 T3086 punct -,distal
R1806 T3088 T3084 prep of,pattern
R1807 T3089 T3090 compound joint,development
R1808 T3090 T3088 pobj development,of
R1809 T3091 T3084 prep in,pattern
R1810 T3092 T3093 det the,limbs
R1811 T3093 T3091 pobj limbs,in
R1812 T3094 T3081 punct ", ",seen
R1813 T3095 T3096 compound LACZ,activity
R1814 T3096 T3081 nsubjpass activity,seen
R1815 T3097 T3081 auxpass is,seen
R1816 T3098 T3081 prep at,seen
R1817 T3099 T3100 amod embryonic,day
R1818 T3100 T3098 pobj day,at
R1819 T3101 T3100 nummod 12.5,day
R1820 T3102 T3100 punct (,day
R1821 T3103 T3100 appos E12.5,day
R1822 T3104 T3100 punct ),day
R1823 T3105 T3081 prep in,seen
R1824 T3106 T3107 det the,joints
R1825 T3107 T3105 pobj joints,in
R1826 T3108 T3109 advmod more,proximal
R1827 T3109 T3107 amod proximal,joints
R1828 T3110 T3107 punct ", ",joints
R1829 T3111 T3107 prep including,joints
R1830 T3112 T3113 det the,shoulder
R1831 T3113 T3111 pobj shoulder,including
R1832 T3114 T3113 cc and,shoulder
R1833 T3115 T3113 conj knee,shoulder
R1834 T3116 T3117 punct (,data
R1835 T3117 T3081 meta data,seen
R1836 T3118 T3117 amod unpublished,data
R1837 T3119 T3117 punct ),data
R1838 T3120 T3081 punct .,seen
R1839 T3122 T3123 prep By,seen
R1840 T3124 T3122 pobj E14.5,By
R1841 T3125 T3123 punct ", ",seen
R1842 T3126 T3127 compound LACZ,expression
R1843 T3127 T3123 nsubjpass expression,seen
R1844 T3128 T3123 auxpass is,seen
R1845 T3129 T3123 advmod typically,seen
R1846 T3130 T3123 prep in,seen
R1847 T3131 T3130 pobj all,in
R1848 T3132 T3131 prep but,all
R1849 T3133 T3134 det the,joints
R1850 T3134 T3132 pobj joints,but
R1851 T3135 T3136 advmod most,distal
R1852 T3136 T3134 amod distal,joints
R1853 T3137 T3134 prep of,joints
R1854 T3138 T3139 det the,limbs
R1855 T3139 T3137 pobj limbs,of
R1856 T3140 T3141 punct (,1B
R1857 T3141 T3123 parataxis 1B,seen
R1858 T3142 T3141 nmod Figure,1B
R1859 T3143 T3141 cc and,1B
R1860 T3144 T3141 conj 1C,1B
R1861 T3145 T3141 punct ),1B
R1862 T3146 T3123 punct ", ",seen
R1863 T3147 T3123 cc but,seen
R1864 T3148 T3147 prep with,but
R1865 T3149 T3150 det some,variability
R1866 T3150 T3148 pobj variability,with
R1867 T3151 T3150 prep in,variability
R1868 T3152 T3153 preconj both,strength
R1869 T3153 T3151 pobj strength,in
R1870 T3154 T3153 cc and,strength
R1871 T3155 T3153 conj extent,strength
R1872 T3156 T3153 prep of,strength
R1873 T3157 T3156 pobj expression,of
R1874 T3158 T3150 prep from,variability
R1875 T3159 T3158 pobj embryo,from
R1876 T3160 T3158 prep to,from
R1877 T3161 T3160 pobj embryo,to
R1878 T3162 T3123 punct .,seen
R1879 T3164 T3165 det The,embryos
R1880 T3165 T3169 nsubj embryos,have
R1881 T3166 T3167 advmod strongest,staining
R1882 T3167 T3165 amod staining,embryos
R1883 T3168 T3167 punct -,staining
R1884 T3170 T3169 advmod often,have
R1885 T3171 T3172 amod additional,staining
R1886 T3172 T3169 dobj staining,have
R1887 T3173 T3172 prep in,staining
R1888 T3174 T3173 pobj fingertips,in
R1889 T3175 T3176 punct (,seen
R1890 T3176 T3169 parataxis seen,have
R1891 T3177 T3176 neg not,seen
R1892 T3178 T3176 prep in,seen
R1893 T3179 T3180 det the,embryo
R1894 T3180 T3178 pobj embryo,in
R1895 T3181 T3180 compound E14.5,embryo
R1896 T3182 T3180 prep in,embryo
R1897 T3183 T3182 pobj Figure,in
R1898 T3184 T3183 nummod 1C,Figure
R1899 T3185 T3176 punct ", ",seen
R1900 T3186 T3176 cc but,seen
R1901 T3187 T3188 advmod clearly,detectable
R1902 T3188 T3176 conj detectable,seen
R1903 T3189 T3188 prep in,detectable
R1904 T3190 T3191 det the,embryo
R1905 T3191 T3189 pobj embryo,in
R1906 T3192 T3191 compound E13.5,embryo
R1907 T3193 T3191 acl shown,embryo
R1908 T3194 T3193 prep in,shown
R1909 T3195 T3194 pobj Figure,in
R1910 T3196 T3195 nummod 2,Figure
R1911 T3197 T3176 punct ),seen
R1912 T3198 T3169 punct .,have
R1913 T3200 T3201 nsubj Sections,show
R1914 T3202 T3200 prep through,Sections
R1915 T3203 T3204 amod developing,joints
R1916 T3204 T3202 pobj joints,through
R1917 T3205 T3206 mark that,is
R1918 T3206 T3201 ccomp is,show
R1919 T3207 T3206 nsubj LACZ,is
R1920 T3208 T3206 acomp present,is
R1921 T3209 T3206 prep in,is
R1922 T3210 T3211 amod many,cells
R1923 T3211 T3209 pobj cells,in
R1924 T3212 T3206 prep at,is
R1925 T3213 T3214 det the,stage
R1926 T3214 T3212 pobj stage,at
R1927 T3215 T3214 compound interzone,stage
R1928 T3216 T3217 punct (,data
R1929 T3217 T3201 meta data,show
R1930 T3218 T3217 amod unpublished,data
R1931 T3219 T3217 punct ),data
R1932 T3220 T3201 punct .,show
R1933 T3222 T3223 advmod However,achieved
R1934 T3224 T3223 punct ", ",achieved
R1935 T3225 T3223 nsubjpass expression,achieved
R1936 T3226 T3225 prep of,expression
R1937 T3227 T3226 pobj LACZ,of
R1938 T3228 T3225 prep in,expression
R1939 T3229 T3230 advmod nearly,100
R1940 T3230 T3231 nummod 100,%
R1941 T3231 T3228 pobj %,in
R1942 T3232 T3231 prep of,%
R1943 T3233 T3234 compound joint,cells
R1944 T3234 T3232 pobj cells,of
R1945 T3235 T3223 auxpass is,achieved
R1946 T3236 T3223 neg not,achieved
R1947 T3237 T3223 prep until,achieved
R1948 T3238 T3239 det the,stage
R1949 T3239 T3237 pobj stage,until
R1950 T3240 T3241 nummod three,layer
R1951 T3241 T3239 compound layer,stage
R1952 T3242 T3241 punct -,layer
R1953 T3243 T3239 compound interzone,stage
R1954 T3244 T3245 punct (,for
R1955 T3245 T3223 parataxis for,achieved
R1956 T3246 T3245 pobj example,for
R1957 T3247 T3245 punct ", ",for
R1958 T3248 T3245 conj in,for
R1959 T3249 T3250 det the,joint
R1960 T3250 T3248 pobj joint,in
R1961 T3251 T3250 compound knee,joint
R1962 T3252 T3250 prep at,joint
R1963 T3253 T3252 pobj E14.5,at
R1964 T3254 T3248 cc or,in
R1965 T3255 T3248 conj in,in
R1966 T3256 T3255 pobj any,in
R1967 T3257 T3256 prep of,any
R1968 T3258 T3259 det the,joints
R1969 T3259 T3257 pobj joints,of
R1970 T3260 T3259 amod phalangeal,joints
R1971 T3261 T3256 prep at,any
R1972 T3262 T3261 pobj E16.5,at
R1973 T3263 T3264 punct (,data
R1974 T3264 T3223 meta data,achieved
R1975 T3265 T3264 amod unpublished,data
R1976 T3266 T3264 punct ),data
R1977 T3267 T3223 punct .,achieved
R1978 T3269 T3270 prep Within,remains
R1979 T3271 T3272 det the,skeleton
R1980 T3272 T3269 pobj skeleton,Within
R1981 T3273 T3272 amod developing,skeleton
R1982 T3274 T3270 punct ", ",remains
R1983 T3275 T3276 npadvmod Cre,mediated
R1984 T3276 T3278 amod mediated,expression
R1985 T3277 T3276 punct -,mediated
R1986 T3278 T3270 nsubj expression,remains
R1987 T3279 T3278 prep of,expression
R1988 T3280 T3279 pobj LACZ,of
R1989 T3281 T3282 advmod strikingly,specific
R1990 T3282 T3270 oprd specific,remains
R1991 T3283 T3282 prep to,specific
R1992 T3284 T3283 pobj joints,to
R1993 T3285 T3270 prep throughout,remains
R1994 T3286 T3285 pobj development,throughout
R1995 T3287 T3270 punct .,remains
R1996 T3289 T3290 advmod Furthermore,seen
R1997 T3291 T3290 punct ", ",seen
R1998 T3292 T3290 nsubjpass it,seen
R1999 T3293 T3290 auxpass is,seen
R2000 T3294 T3290 prep in,seen
R2001 T3295 T3296 predet all,structures
R2002 T3296 T3294 pobj structures,in
R2003 T3297 T3296 det the,structures
R2004 T3298 T3296 prep of,structures
R2005 T3299 T3300 amod postnatal,joints
R2006 T3300 T3298 pobj joints,of
R2007 T3301 T3300 amod synovial,joints
R2008 T3302 T3296 prep including,structures
R2009 T3303 T3304 det the,cartilage
R2010 T3304 T3302 pobj cartilage,including
R2011 T3305 T3304 amod articular,cartilage
R2012 T3306 T3304 punct ", ",cartilage
R2013 T3307 T3308 compound joint,capsule
R2014 T3308 T3304 conj capsule,cartilage
R2015 T3309 T3308 punct ", ",capsule
R2016 T3310 T3308 cc and,capsule
R2017 T3311 T3312 amod synovial,membrane
R2018 T3312 T3308 conj membrane,capsule
R2019 T3313 T3314 punct (,Figure
R2020 T3314 T3290 parataxis Figure,seen
R2021 T3315 T3314 nummod 1D,Figure
R2022 T3316 T3314 cc and,Figure
R2023 T3317 T3314 conj 1E,Figure
R2024 T3318 T3314 punct ),Figure
R2025 T3319 T3320 punct (,data
R2026 T3320 T3290 meta data,seen
R2027 T3321 T3320 amod unpublished,data
R2028 T3322 T3320 punct ),data
R2029 T3323 T3290 punct .,seen
R2030 T3325 T3326 det These,patterns
R2031 T3326 T3327 nsubj patterns,are
R2032 T3328 T3327 acomp consistent,are
R2033 T3329 T3328 prep with,consistent
R2034 T3330 T3331 det the,expression
R2035 T3331 T3329 pobj expression,with
R2036 T3332 T3333 advmod well,established
R2037 T3333 T3331 amod established,expression
R2038 T3334 T3333 punct -,established
R2039 T3335 T3331 prep of,expression
R2040 T3336 T3335 pobj Gdf5,of
R2041 T3337 T3331 prep in,expression
R2042 T3338 T3339 compound interzone,regions
R2043 T3339 T3337 pobj regions,in
R2044 T3340 T3331 prep during,expression
R2045 T3341 T3342 amod embryonic,development
R2046 T3342 T3340 pobj development,during
R2047 T3343 T3344 punct (,Storm
R2048 T3344 T3327 meta Storm,are
R2049 T3345 T3344 cc and,Storm
R2050 T3346 T3344 conj Kingsley,Storm
R2051 T3347 T3346 nummod 1996,Kingsley
R2052 T3348 T3346 punct ),Kingsley
R2053 T3349 T3327 punct .,are
R2054 T3351 T3352 compound Adult,patterns
R2055 T3352 T3354 nsubj patterns,are
R2056 T3353 T3352 compound expression,patterns
R2057 T3355 T3352 prep of,patterns
R2058 T3356 T3357 det the,gene
R2059 T3357 T3355 pobj gene,of
R2060 T3358 T3357 compound Gdf5,gene
R2061 T3359 T3354 neg not,are
R2062 T3360 T3361 advmod as,characterized
R2063 T3361 T3354 acomp characterized,are
R2064 T3362 T3361 advmod well,characterized
R2065 T3363 T3354 punct ", ",are
R2066 T3364 T3354 cc but,are
R2067 T3365 T3366 compound Gdf5,expression
R2068 T3366 T3367 nsubjpass expression,detected
R2069 T3367 T3354 conj detected,are
R2070 T3368 T3367 aux has,detected
R2071 T3369 T3367 advmod previously,detected
R2072 T3370 T3367 auxpass been,detected
R2073 T3371 T3367 prep in,detected
R2074 T3372 T3373 nmod adult,cartilage
R2080 T3373 T3371 pobj cartilage,in
R2082 T3374 T3373 amod articular,cartilage
R2084 T3375 T3367 advcl using,detected
R2085 T3376 T3377 preconj both,PCR
R2086 T3377 T3375 dobj PCR,using
R2087 T3378 T3377 compound RT,PCR
R2088 T3379 T3377 punct -,PCR
R2090 T3380 T3377 cc and,PCR
R2091 T3381 T3377 conj immunocytochemistry,PCR
R2092 T3382 T3383 punct (,Chang
R2093 T3383 T3367 meta Chang,detected
R2094 T3384 T3383 nmod et,Chang
R2096 T3385 T3383 nmod al.,Chang
R2097 T3386 T3383 nummod 1994,Chang
R2098 T3387 T3383 punct ;,Chang
R2100 T3388 T3383 nmod Erlacher,Chang
R2103 T3389 T3383 nmod et,Chang
R2104 T3390 T3383 nmod al.,Chang
R2105 T3391 T3383 nummod 1998,Chang
R2107 T3392 T3383 punct ;,Chang
R2108 T3393 T3383 nmod Bobacz,Chang
R2110 T3394 T3383 nmod et,Chang
R2111 T3395 T3383 nmod al.,Chang
R2112 T3396 T3383 nummod 2002,Chang
R2114 T3397 T3383 punct ),Chang
R2115 T3398 T3367 punct .,detected