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PMC:509410 / 6908-9471 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T1638 0-4 NN denotes Type
T1640 5-6 CD denotes I
T1639 7-13 NN denotes muscle
T1642 14-17 MD denotes can
T1643 18-20 VB denotes be
T1644 21-28 RB denotes readily
T1641 29-42 VBN denotes distinguished
T1645 43-47 IN denotes from
T1646 48-52 NN denotes type
T1648 53-55 CD denotes II
T1649 56-58 CC denotes or
T1650 59-64 VBN denotes mixed
T1647 65-71 NN denotes muscle
T1651 72-74 IN denotes by
T1652 75-78 PRP$ denotes its
T1654 79-82 JJ denotes red
T1653 83-88 NN denotes color
T1655 88-90 , denotes ,
T1656 90-97 IN denotes because
T1657 98-100 IN denotes of
T1658 101-104 PRP$ denotes its
T1660 105-109 JJ denotes high
T1659 110-123 NN denotes concentration
T1661 124-126 IN denotes of
T1662 127-136 NN denotes myoglobin
T1663 136-138 , denotes ,
T1664 138-139 DT denotes a
T1665 140-147 NN denotes protein
T1666 148-157 RB denotes typically
T1667 158-167 VBN denotes expressed
T1668 168-170 IN denotes in
T1669 171-180 JJ denotes oxidative
T1671 181-187 NN denotes muscle
T1670 188-194 NNS denotes fibers
T1672 194-195 . denotes .
T1673 195-358 sentence denotes We found that muscles in the transgenic mice appeared redder (Figure 2A), which is particularly evident in the mixed type I/II fibers of the hindlimb (Figure 2B).
T1674 196-198 PRP denotes We
T1675 199-204 VBD denotes found
T1676 205-209 IN denotes that
T1678 210-217 NNS denotes muscles
T1679 218-220 IN denotes in
T1680 221-224 DT denotes the
T1682 225-235 JJ denotes transgenic
T1681 236-240 NNS denotes mice
T1677 241-249 VBD denotes appeared
T1683 250-256 JJR denotes redder
T1684 257-258 -LRB- denotes (
T1685 258-264 NN denotes Figure
T1686 265-267 CD denotes 2A
T1687 267-268 -RRB- denotes )
T1688 268-270 , denotes ,
T1689 270-275 WDT denotes which
T1690 276-278 VBZ denotes is
T1691 279-291 RB denotes particularly
T1692 292-299 JJ denotes evident
T1693 300-302 IN denotes in
T1694 303-306 DT denotes the
T1696 307-312 JJ denotes mixed
T1698 313-317 NN denotes type
T1699 318-319 CD denotes I
T1700 319-320 HYPH denotes /
T1697 320-322 CD denotes II
T1695 323-329 NNS denotes fibers
T1701 330-332 IN denotes of
T1702 333-336 DT denotes the
T1703 337-345 NN denotes hindlimb
T1704 346-347 -LRB- denotes (
T1705 347-353 NN denotes Figure
T1706 354-356 CD denotes 2B
T1707 356-357 -RRB- denotes )
T1708 357-358 . denotes .
T1709 358-453 sentence denotes Indeed, metachromatic staining revealed a substantial muscle fiber transformation (Figure 2C).
T1710 359-365 RB denotes Indeed
T1712 365-367 , denotes ,
T1713 367-380 JJ denotes metachromatic
T1714 381-389 NN denotes staining
T1711 390-398 VBD denotes revealed
T1715 399-400 DT denotes a
T1717 401-412 JJ denotes substantial
T1718 413-419 NN denotes muscle
T1719 420-425 NN denotes fiber
T1716 426-440 NN denotes transformation
T1720 441-442 -LRB- denotes (
T1721 442-448 NN denotes Figure
T1722 449-451 CD denotes 2C
T1723 451-452 -RRB- denotes )
T1724 452-453 . denotes .
T1725 453-542 sentence denotes In gastrocnemius muscle, we estimated that there was a 2-fold increase of type I fibers.
T1726 454-456 IN denotes In
T1728 457-470 NN denotes gastrocnemius
T1729 471-477 NN denotes muscle
T1730 477-479 , denotes ,
T1731 479-481 PRP denotes we
T1727 482-491 VBD denotes estimated
T1732 492-496 IN denotes that
T1734 497-502 EX denotes there
T1733 503-506 VBD denotes was
T1735 507-508 DT denotes a
T1737 509-515 JJ denotes 2-fold
T1736 516-524 NN denotes increase
T1738 525-527 IN denotes of
T1739 528-532 NN denotes type
T1741 533-534 CD denotes I
T1740 535-541 NNS denotes fibers
T1742 541-542 . denotes .
T1743 542-696 sentence denotes A diagnostic component of oxidative fibers is their high myoglobin and mitochondrial content, which is supported by the mRNA analysis shown in Figure 3A.
T1744 543-544 DT denotes A
T1746 545-555 JJ denotes diagnostic
T1745 556-565 NN denotes component
T1748 566-568 IN denotes of
T1749 569-578 JJ denotes oxidative
T1750 579-585 NNS denotes fibers
T1747 586-588 VBZ denotes is
T1751 589-594 PRP$ denotes their
T1753 595-599 JJ denotes high
T1754 600-609 NN denotes myoglobin
T1755 610-613 CC denotes and
T1756 614-627 JJ denotes mitochondrial
T1752 628-635 NN denotes content
T1757 635-637 , denotes ,
T1758 637-642 WDT denotes which
T1760 643-645 VBZ denotes is
T1759 646-655 VBN denotes supported
T1761 656-658 IN denotes by
T1762 659-662 DT denotes the
T1764 663-667 NN denotes mRNA
T1763 668-676 NN denotes analysis
T1765 677-682 VBN denotes shown
T1766 683-685 IN denotes in
T1767 686-692 NN denotes Figure
T1768 693-695 CD denotes 3A
T1769 695-696 . denotes .
T1770 696-905 sentence denotes In addition to myoglobin, mitochondrial components for electron transfer (cytochrome c and cytochrome c oxidase [COX] II and IV) and fatty-acid β-oxidation enzymes were elevated (Figure 3A; unpublished data).
T1771 697-699 IN denotes In
T1773 700-708 NN denotes addition
T1774 709-711 IN denotes to
T1775 712-721 NN denotes myoglobin
T1776 721-723 , denotes ,
T1777 723-736 JJ denotes mitochondrial
T1778 737-747 NNS denotes components
T1779 748-751 IN denotes for
T1780 752-760 NN denotes electron
T1781 761-769 NN denotes transfer
T1782 770-771 -LRB- denotes (
T1784 771-781 NN denotes cytochrome
T1783 782-783 NN denotes c
T1785 784-787 CC denotes and
T1786 788-798 NN denotes cytochrome
T1787 799-800 NN denotes c
T1788 801-808 NN denotes oxidase
T1789 809-810 -LRB- denotes [
T1790 810-813 NN denotes COX
T1791 813-814 -RRB- denotes ]
T1792 815-817 CD denotes II
T1793 818-821 CC denotes and
T1794 822-824 CD denotes IV
T1795 824-825 -RRB- denotes )
T1796 826-829 CC denotes and
T1797 830-835 JJ denotes fatty
T1799 835-836 HYPH denotes -
T1798 836-840 NN denotes acid
T1801 841-842 NN denotes β
T1803 842-843 HYPH denotes -
T1802 843-852 NN denotes oxidation
T1800 853-860 NNS denotes enzymes
T1804 861-865 VBD denotes were
T1772 866-874 VBN denotes elevated
T1805 875-876 -LRB- denotes (
T1807 876-882 NN denotes Figure
T1808 883-885 CD denotes 3A
T1809 885-886 : denotes ;
T1810 887-898 JJ denotes unpublished
T1806 899-903 NNS denotes data
T1811 903-904 -RRB- denotes )
T1812 904-905 . denotes .
T1813 905-1144 sentence denotes These effects appear to be direct consequences of PPARδ activation, as levels of PGC-1α, a coactivator involved in muscle fiber switch and mitochondrial biogenesis (Wu et al. 1999; Lehman et al. 2000; Lin et al. 2002), remained unchanged.
T1814 906-911 DT denotes These
T1815 912-919 NNS denotes effects
T1816 920-926 VBP denotes appear
T1817 927-929 TO denotes to
T1818 930-932 VB denotes be
T1819 933-939 JJ denotes direct
T1820 940-952 NNS denotes consequences
T1821 953-955 IN denotes of
T1822 956-961 NN denotes PPARδ
T1823 962-972 NN denotes activation
T1824 972-974 , denotes ,
T1825 974-976 IN denotes as
T1827 977-983 NNS denotes levels
T1828 984-986 IN denotes of
T1829 987-990 NN denotes PGC
T1830 990-991 HYPH denotes -
T1831 991-993 CD denotes 1α
T1832 993-995 , denotes ,
T1833 995-996 DT denotes a
T1834 997-1008 NN denotes coactivator
T1835 1009-1017 VBN denotes involved
T1836 1018-1020 IN denotes in
T1837 1021-1027 NN denotes muscle
T1838 1028-1033 NN denotes fiber
T1839 1034-1040 NN denotes switch
T1840 1041-1044 CC denotes and
T1841 1045-1058 JJ denotes mitochondrial
T1842 1059-1069 NN denotes biogenesis
T1843 1070-1071 -LRB- denotes (
T1844 1071-1073 NNP denotes Wu
T1845 1074-1076 FW denotes et
T1846 1077-1080 FW denotes al.
T1847 1081-1085 CD denotes 1999
T1848 1085-1086 : denotes ;
T1849 1087-1093 NNP denotes Lehman
T1850 1094-1096 FW denotes et
T1851 1097-1100 FW denotes al.
T1852 1101-1105 CD denotes 2000
T1853 1105-1106 : denotes ;
T1854 1107-1110 NNP denotes Lin
T1855 1111-1113 FW denotes et
T1856 1114-1117 FW denotes al.
T1857 1118-1122 CD denotes 2002
T1858 1122-1123 -RRB- denotes )
T1859 1123-1125 , denotes ,
T1826 1125-1133 VBD denotes remained
T1860 1134-1143 JJ denotes unchanged
T1861 1143-1144 . denotes .
T1862 1144-1293 sentence denotes Southern blot analysis detected a substantially higher copy number of the mitochondrial genome–encoded COXII DNA in the transgenic mice (Figure 3B).
T1863 1145-1153 NNP denotes Southern
T1864 1154-1158 NN denotes blot
T1865 1159-1167 NN denotes analysis
T1866 1168-1176 VBD denotes detected
T1867 1177-1178 DT denotes a
T1869 1179-1192 RB denotes substantially
T1870 1193-1199 JJR denotes higher
T1871 1200-1204 NN denotes copy
T1868 1205-1211 NN denotes number
T1872 1212-1214 IN denotes of
T1873 1215-1218 DT denotes the
T1875 1219-1232 JJ denotes mitochondrial
T1876 1233-1239 NN denotes genome
T1878 1239-1240 HYPH denotes –
T1877 1240-1247 VBN denotes encoded
T1879 1248-1253 NN denotes COXII
T1874 1254-1257 NN denotes DNA
T1880 1258-1260 IN denotes in
T1881 1261-1264 DT denotes the
T1883 1265-1275 JJ denotes transgenic
T1882 1276-1280 NNS denotes mice
T1884 1281-1282 -LRB- denotes (
T1885 1282-1288 NN denotes Figure
T1886 1289-1291 CD denotes 3B
T1887 1291-1292 -RRB- denotes )
T1888 1292-1293 . denotes .
T1889 1293-1394 sentence denotes Mitochondrial DNA was increased 2.3-fold in gastrocnemius muscle of the transgenic mice (Figure 3C).
T1890 1294-1307 JJ denotes Mitochondrial
T1891 1308-1311 NN denotes DNA
T1893 1312-1315 VBD denotes was
T1892 1316-1325 VBN denotes increased
T1894 1326-1329 CD denotes 2.3
T1895 1329-1330 HYPH denotes -
T1896 1330-1334 RB denotes fold
T1897 1335-1337 IN denotes in
T1898 1338-1351 NN denotes gastrocnemius
T1899 1352-1358 NN denotes muscle
T1900 1359-1361 IN denotes of
T1901 1362-1365 DT denotes the
T1903 1366-1376 JJ denotes transgenic
T1902 1377-1381 NNS denotes mice
T1904 1382-1383 -LRB- denotes (
T1905 1383-1389 NN denotes Figure
T1906 1390-1392 CD denotes 3C
T1907 1392-1393 -RRB- denotes )
T1908 1393-1394 . denotes .
T1909 1394-1530 sentence denotes These results reveal a marked stimulation of mitochondrial biogenesis and further support the idea that there is a muscle fiber switch.
T1910 1395-1400 DT denotes These
T1911 1401-1408 NNS denotes results
T1912 1409-1415 VBP denotes reveal
T1913 1416-1417 DT denotes a
T1915 1418-1424 JJ denotes marked
T1914 1425-1436 NN denotes stimulation
T1916 1437-1439 IN denotes of
T1917 1440-1453 JJ denotes mitochondrial
T1918 1454-1464 NN denotes biogenesis
T1919 1465-1468 CC denotes and
T1920 1469-1476 RB denotes further
T1921 1477-1484 VBP denotes support
T1922 1485-1488 DT denotes the
T1923 1489-1493 NN denotes idea
T1924 1494-1498 IN denotes that
T1926 1499-1504 EX denotes there
T1925 1505-1507 VBZ denotes is
T1927 1508-1509 DT denotes a
T1929 1510-1516 NN denotes muscle
T1930 1517-1522 NN denotes fiber
T1928 1523-1529 NN denotes switch
T1931 1529-1530 . denotes .
T1932 1530-1591 sentence denotes This conclusion was also confirmed by Western blot analysis.
T1933 1531-1535 DT denotes This
T1934 1536-1546 NN denotes conclusion
T1936 1547-1550 VBD denotes was
T1937 1551-1555 RB denotes also
T1935 1556-1565 VBN denotes confirmed
T1938 1566-1568 IN denotes by
T1939 1569-1576 NNP denotes Western
T1940 1577-1581 NN denotes blot
T1941 1582-1590 NN denotes analysis
T1942 1590-1591 . denotes .
T1943 1591-1728 sentence denotes As shown in Figure 3D, the characteristic type I fiber proteins, such as myoglobin and cytochrome c and b, were significantly increased.
T1944 1592-1594 IN denotes As
T1945 1595-1600 VBN denotes shown
T1947 1601-1603 IN denotes in
T1948 1604-1610 NN denotes Figure
T1949 1611-1613 CD denotes 3D
T1950 1613-1615 , denotes ,
T1951 1615-1618 DT denotes the
T1953 1619-1633 JJ denotes characteristic
T1954 1634-1638 NN denotes type
T1956 1639-1640 CD denotes I
T1955 1641-1646 NN denotes fiber
T1952 1647-1655 NN denotes proteins
T1957 1655-1657 , denotes ,
T1958 1657-1661 JJ denotes such
T1959 1662-1664 IN denotes as
T1960 1665-1674 NN denotes myoglobin
T1961 1675-1678 CC denotes and
T1962 1679-1689 NN denotes cytochrome
T1964 1690-1691 NN denotes c
T1965 1692-1695 CC denotes and
T1963 1696-1697 NN denotes b
T1966 1697-1699 , denotes ,
T1967 1699-1703 VBD denotes were
T1968 1704-1717 RB denotes significantly
T1946 1718-1727 VBN denotes increased
T1969 1727-1728 . denotes .
T1970 1728-2006 sentence denotes More importantly, the specialized contraction protein troponin I (slow) of type I fiber was robustly induced; this was accompanied by a marked reduction of the specialized contraction protein troponin I (fast) of type II fiber, indicating a high degree of fiber transformation.
T1971 1729-1733 RBR denotes More
T1972 1734-1745 RB denotes importantly
T1974 1745-1747 , denotes ,
T1975 1747-1750 DT denotes the
T1977 1751-1762 VBN denotes specialized
T1978 1763-1774 NN denotes contraction
T1976 1775-1782 NN denotes protein
T1979 1783-1791 NN denotes troponin
T1980 1792-1793 CD denotes I
T1981 1794-1795 -LRB- denotes (
T1982 1795-1799 JJ denotes slow
T1983 1799-1800 -RRB- denotes )
T1984 1801-1803 IN denotes of
T1985 1804-1808 NN denotes type
T1987 1809-1810 CD denotes I
T1986 1811-1816 NN denotes fiber
T1988 1817-1820 VBD denotes was
T1989 1821-1829 RB denotes robustly
T1973 1830-1837 VBN denotes induced
T1991 1837-1838 : denotes ;
T1992 1839-1843 DT denotes this
T1993 1844-1847 VBD denotes was
T1990 1848-1859 VBN denotes accompanied
T1994 1860-1862 IN denotes by
T1995 1863-1864 DT denotes a
T1997 1865-1871 JJ denotes marked
T1996 1872-1881 NN denotes reduction
T1998 1882-1884 IN denotes of
T1999 1885-1888 DT denotes the
T2001 1889-1900 VBN denotes specialized
T2002 1901-1912 NN denotes contraction
T2000 1913-1920 NN denotes protein
T2003 1921-1929 NN denotes troponin
T2004 1930-1931 CD denotes I
T2005 1932-1933 -LRB- denotes (
T2006 1933-1937 JJ denotes fast
T2007 1937-1938 -RRB- denotes )
T2008 1939-1941 IN denotes of
T2009 1942-1946 NN denotes type
T2011 1947-1949 CD denotes II
T2010 1950-1955 NN denotes fiber
T2012 1955-1957 , denotes ,
T2013 1957-1967 VBG denotes indicating
T2014 1968-1969 DT denotes a
T2016 1970-1974 JJ denotes high
T2015 1975-1981 NN denotes degree
T2017 1982-1984 IN denotes of
T2018 1985-1990 NN denotes fiber
T2019 1991-2005 NN denotes transformation
T2020 2005-2006 . denotes .
T2021 2006-2103 sentence denotes We next examined whether acute activation of endogenous PPARδ would induce similar target genes.
T2022 2007-2009 PRP denotes We
T2024 2010-2014 RB denotes next
T2023 2015-2023 VBD denotes examined
T2025 2024-2031 IN denotes whether
T2027 2032-2037 JJ denotes acute
T2028 2038-2048 NN denotes activation
T2029 2049-2051 IN denotes of
T2030 2052-2062 JJ denotes endogenous
T2031 2063-2068 NN denotes PPARδ
T2032 2069-2074 MD denotes would
T2026 2075-2081 VB denotes induce
T2033 2082-2089 JJ denotes similar
T2035 2090-2096 NN denotes target
T2034 2097-2102 NNS denotes genes
T2036 2102-2103 . denotes .
T2037 2103-2396 sentence denotes In agreement with the chronic effects in the transgenic mice, we found that, after treatment of wild-type C57B6J mice with the PPARδ-specific agonist GW501516 for only 10 d, genes for slow fiber contractile proteins, mitochondrial biogenesis, and β-oxidation were all upregulated (Figure 3E).
T2038 2104-2106 IN denotes In
T2040 2107-2116 NN denotes agreement
T2041 2117-2121 IN denotes with
T2042 2122-2125 DT denotes the
T2044 2126-2133 JJ denotes chronic
T2043 2134-2141 NNS denotes effects
T2045 2142-2144 IN denotes in
T2046 2145-2148 DT denotes the
T2048 2149-2159 JJ denotes transgenic
T2047 2160-2164 NNS denotes mice
T2049 2164-2166 , denotes ,
T2050 2166-2168 PRP denotes we
T2039 2169-2174 VBD denotes found
T2051 2175-2179 IN denotes that
T2053 2179-2181 , denotes ,
T2054 2181-2186 IN denotes after
T2055 2187-2196 NN denotes treatment
T2056 2197-2199 IN denotes of
T2057 2200-2204 JJ denotes wild
T2059 2204-2205 HYPH denotes -
T2058 2205-2209 NN denotes type
T2061 2210-2216 NN denotes C57B6J
T2060 2217-2221 NNS denotes mice
T2062 2222-2226 IN denotes with
T2063 2227-2230 DT denotes the
T2065 2231-2236 NN denotes PPARδ
T2067 2236-2237 HYPH denotes -
T2066 2237-2245 JJ denotes specific
T2068 2246-2253 NN denotes agonist
T2064 2254-2262 NN denotes GW501516
T2069 2263-2266 IN denotes for
T2070 2267-2271 RB denotes only
T2072 2272-2274 CD denotes 10
T2071 2275-2276 NNS denotes d
T2073 2276-2278 , denotes ,
T2074 2278-2283 NNS denotes genes
T2075 2284-2287 IN denotes for
T2076 2288-2292 JJ denotes slow
T2077 2293-2298 NN denotes fiber
T2079 2299-2310 JJ denotes contractile
T2078 2311-2319 NN denotes proteins
T2080 2319-2321 , denotes ,
T2081 2321-2334 JJ denotes mitochondrial
T2082 2335-2345 NN denotes biogenesis
T2083 2345-2347 , denotes ,
T2084 2347-2350 CC denotes and
T2085 2351-2352 NN denotes β
T2087 2352-2353 HYPH denotes -
T2086 2353-2362 NN denotes oxidation
T2088 2363-2367 VBD denotes were
T2089 2368-2371 RB denotes all
T2052 2372-2383 VBN denotes upregulated
T2090 2384-2385 -LRB- denotes (
T2091 2385-2391 NN denotes Figure
T2092 2392-2394 CD denotes 3E
T2093 2394-2395 -RRB- denotes )
T2094 2395-2396 . denotes .
T2095 2396-2563 sentence denotes This indicates that rapid, systematic, and coordinated changes of muscle fiber properties toward type I can be achieved by activation of the endogenous PPARδ pathway.
T2096 2397-2401 DT denotes This
T2097 2402-2411 VBZ denotes indicates
T2098 2412-2416 IN denotes that
T2100 2417-2422 JJ denotes rapid
T2102 2422-2424 , denotes ,
T2103 2424-2434 JJ denotes systematic
T2104 2434-2436 , denotes ,
T2105 2436-2439 CC denotes and
T2106 2440-2451 VBN denotes coordinated
T2101 2452-2459 NNS denotes changes
T2107 2460-2462 IN denotes of
T2108 2463-2469 NN denotes muscle
T2110 2470-2475 NN denotes fiber
T2109 2476-2486 NNS denotes properties
T2111 2487-2493 IN denotes toward
T2112 2494-2498 NN denotes type
T2113 2499-2500 CD denotes I
T2114 2501-2504 MD denotes can
T2115 2505-2507 VB denotes be
T2099 2508-2516 VBN denotes achieved
T2116 2517-2519 IN denotes by
T2117 2520-2530 NN denotes activation
T2118 2531-2533 IN denotes of
T2119 2534-2537 DT denotes the
T2121 2538-2548 JJ denotes endogenous
T2122 2549-2554 NN denotes PPARδ
T2120 2555-2562 NN denotes pathway
T2123 2562-2563 . denotes .
R1062 T1638 T1639 nmod Type,muscle
R1063 T1639 T1641 nsubjpass muscle,distinguished
R1064 T1640 T1638 nummod I,Type
R1065 T1642 T1641 aux can,distinguished
R1066 T1643 T1641 auxpass be,distinguished
R1067 T1644 T1641 advmod readily,distinguished
R1068 T1645 T1641 prep from,distinguished
R1069 T1646 T1647 nmod type,muscle
R1070 T1647 T1645 pobj muscle,from
R1071 T1648 T1646 nummod II,type
R1072 T1649 T1646 cc or,type
R1073 T1650 T1646 conj mixed,type
R1074 T1651 T1641 prep by,distinguished
R1075 T1652 T1653 poss its,color
R1076 T1653 T1651 pobj color,by
R1077 T1654 T1653 amod red,color
R1078 T1655 T1641 punct ", ",distinguished
R1079 T1656 T1641 prep because,distinguished
R1080 T1657 T1656 prep of,because
R1081 T1658 T1659 poss its,concentration
R1082 T1659 T1657 pobj concentration,of
R1083 T1660 T1659 amod high,concentration
R1084 T1661 T1659 prep of,concentration
R1085 T1662 T1661 pobj myoglobin,of
R1086 T1663 T1662 punct ", ",myoglobin
R1087 T1664 T1665 det a,protein
R1088 T1665 T1662 appos protein,myoglobin
R1089 T1666 T1667 advmod typically,expressed
R1090 T1667 T1665 acl expressed,protein
R1091 T1668 T1667 prep in,expressed
R1092 T1669 T1670 amod oxidative,fibers
R1093 T1670 T1668 pobj fibers,in
R1094 T1671 T1670 compound muscle,fibers
R1095 T1672 T1641 punct .,distinguished
R1096 T1674 T1675 nsubj We,found
R1097 T1676 T1677 mark that,appeared
R1098 T1677 T1675 ccomp appeared,found
R1099 T1678 T1677 nsubj muscles,appeared
R1100 T1679 T1678 prep in,muscles
R1101 T1680 T1681 det the,mice
R1102 T1681 T1679 pobj mice,in
R1103 T1682 T1681 amod transgenic,mice
R1104 T1683 T1677 oprd redder,appeared
R1105 T1684 T1685 punct (,Figure
R1106 T1685 T1677 parataxis Figure,appeared
R1107 T1686 T1685 nummod 2A,Figure
R1108 T1687 T1685 punct ),Figure
R1109 T1688 T1677 punct ", ",appeared
R1110 T1689 T1690 dep which,is
R1111 T1690 T1677 advcl is,appeared
R1112 T1691 T1692 advmod particularly,evident
R1113 T1692 T1690 acomp evident,is
R1114 T1693 T1690 prep in,is
R1115 T1694 T1695 det the,fibers
R1116 T1695 T1693 pobj fibers,in
R1117 T1696 T1697 amod mixed,II
R1118 T1697 T1695 nummod II,fibers
R1119 T1698 T1697 nmod type,II
R1120 T1699 T1697 nummod I,II
R1121 T1700 T1697 punct /,II
R1122 T1701 T1695 prep of,fibers
R1123 T1702 T1703 det the,hindlimb
R1124 T1703 T1701 pobj hindlimb,of
R1125 T1704 T1705 punct (,Figure
R1126 T1705 T1690 parataxis Figure,is
R1127 T1706 T1705 nummod 2B,Figure
R1128 T1707 T1705 punct ),Figure
R1129 T1708 T1675 punct .,found
R1130 T1710 T1711 advmod Indeed,revealed
R1131 T1712 T1711 punct ", ",revealed
R1132 T1713 T1714 amod metachromatic,staining
R1133 T1714 T1711 nsubj staining,revealed
R1134 T1715 T1716 det a,transformation
R1135 T1716 T1711 dobj transformation,revealed
R1136 T1717 T1716 amod substantial,transformation
R1137 T1718 T1719 compound muscle,fiber
R1138 T1719 T1716 compound fiber,transformation
R1139 T1720 T1721 punct (,Figure
R1140 T1721 T1711 parataxis Figure,revealed
R1141 T1722 T1721 nummod 2C,Figure
R1142 T1723 T1721 punct ),Figure
R1143 T1724 T1711 punct .,revealed
R1144 T1726 T1727 prep In,estimated
R1145 T1728 T1729 compound gastrocnemius,muscle
R1146 T1729 T1726 pobj muscle,In
R1147 T1730 T1727 punct ", ",estimated
R1148 T1731 T1727 nsubj we,estimated
R1149 T1732 T1733 mark that,was
R1150 T1733 T1727 ccomp was,estimated
R1151 T1734 T1733 expl there,was
R1152 T1735 T1736 det a,increase
R1153 T1736 T1733 attr increase,was
R1154 T1737 T1736 amod 2-fold,increase
R1155 T1738 T1736 prep of,increase
R1156 T1739 T1740 nmod type,fibers
R1157 T1740 T1738 pobj fibers,of
R1158 T1741 T1739 nummod I,type
R1159 T1742 T1727 punct .,estimated
R1160 T1744 T1745 det A,component
R1161 T1745 T1747 nsubj component,is
R1162 T1746 T1745 amod diagnostic,component
R1163 T1748 T1745 prep of,component
R1164 T1749 T1750 amod oxidative,fibers
R1165 T1750 T1748 pobj fibers,of
R1166 T1751 T1752 poss their,content
R1167 T1752 T1747 attr content,is
R1168 T1753 T1752 amod high,content
R1169 T1754 T1752 nmod myoglobin,content
R1170 T1755 T1754 cc and,myoglobin
R1171 T1756 T1754 conj mitochondrial,myoglobin
R1172 T1757 T1752 punct ", ",content
R1173 T1758 T1759 dep which,supported
R1174 T1759 T1752 relcl supported,content
R1175 T1760 T1759 auxpass is,supported
R1176 T1761 T1759 agent by,supported
R1177 T1762 T1763 det the,analysis
R1178 T1763 T1761 pobj analysis,by
R1179 T1764 T1763 compound mRNA,analysis
R1180 T1765 T1763 acl shown,analysis
R1181 T1766 T1765 prep in,shown
R1182 T1767 T1766 pobj Figure,in
R1183 T1768 T1767 nummod 3A,Figure
R1184 T1769 T1747 punct .,is
R1185 T1771 T1772 prep In,elevated
R1186 T1773 T1771 pobj addition,In
R1187 T1774 T1773 prep to,addition
R1188 T1775 T1774 pobj myoglobin,to
R1189 T1776 T1772 punct ", ",elevated
R1190 T1777 T1778 amod mitochondrial,components
R1191 T1778 T1772 nsubjpass components,elevated
R1192 T1779 T1778 prep for,components
R1193 T1780 T1781 compound electron,transfer
R1194 T1781 T1779 pobj transfer,for
R1195 T1782 T1783 punct (,c
R1196 T1783 T1778 parataxis c,components
R1197 T1784 T1783 compound cytochrome,c
R1198 T1785 T1783 cc and,c
R1199 T1786 T1787 compound cytochrome,c
R1200 T1787 T1788 compound c,oxidase
R1201 T1788 T1783 conj oxidase,c
R1202 T1789 T1790 punct [,COX
R1203 T1790 T1788 parataxis COX,oxidase
R1204 T1791 T1790 punct ],COX
R1205 T1792 T1783 appos II,c
R1206 T1793 T1792 cc and,II
R1207 T1794 T1792 conj IV,II
R1208 T1795 T1783 punct ),c
R1209 T1796 T1778 cc and,components
R1210 T1797 T1798 amod fatty,acid
R1211 T1798 T1800 compound acid,enzymes
R1212 T1799 T1798 punct -,acid
R1213 T1800 T1778 conj enzymes,components
R1214 T1801 T1802 compound β,oxidation
R1215 T1802 T1800 compound oxidation,enzymes
R1216 T1803 T1802 punct -,oxidation
R1217 T1804 T1772 auxpass were,elevated
R1218 T1805 T1806 punct (,data
R1219 T1806 T1772 parataxis data,elevated
R1220 T1807 T1806 dep Figure,data
R1221 T1808 T1807 nummod 3A,Figure
R1222 T1809 T1806 punct ;,data
R1223 T1810 T1806 amod unpublished,data
R1224 T1811 T1806 punct ),data
R1225 T1812 T1772 punct .,elevated
R1226 T1814 T1815 det These,effects
R1227 T1815 T1816 nsubj effects,appear
R1228 T1817 T1818 aux to,be
R1229 T1818 T1816 xcomp be,appear
R1230 T1819 T1820 amod direct,consequences
R1231 T1820 T1818 attr consequences,be
R1232 T1821 T1820 prep of,consequences
R1233 T1822 T1823 compound PPARδ,activation
R1234 T1823 T1821 pobj activation,of
R1235 T1824 T1818 punct ", ",be
R1236 T1825 T1826 mark as,remained
R1237 T1826 T1818 advcl remained,be
R1238 T1827 T1826 nsubj levels,remained
R1239 T1828 T1827 prep of,levels
R1240 T1829 T1828 pobj PGC,of
R1241 T1830 T1829 punct -,PGC
R1242 T1831 T1829 nummod 1α,PGC
R1243 T1832 T1829 punct ", ",PGC
R1244 T1833 T1834 det a,coactivator
R1245 T1834 T1829 appos coactivator,PGC
R1246 T1835 T1834 acl involved,coactivator
R1247 T1836 T1835 prep in,involved
R1248 T1837 T1838 compound muscle,fiber
R1249 T1838 T1839 compound fiber,switch
R1250 T1839 T1836 pobj switch,in
R1251 T1840 T1839 cc and,switch
R1252 T1841 T1842 amod mitochondrial,biogenesis
R1253 T1842 T1839 conj biogenesis,switch
R1254 T1843 T1844 punct (,Wu
R1255 T1844 T1835 meta Wu,involved
R1256 T1845 T1844 nmod et,Wu
R1257 T1846 T1844 nmod al.,Wu
R1258 T1847 T1844 nummod 1999,Wu
R1259 T1848 T1844 punct ;,Wu
R1260 T1849 T1844 nmod Lehman,Wu
R1261 T1850 T1844 nmod et,Wu
R1262 T1851 T1844 nmod al.,Wu
R1263 T1852 T1844 nummod 2000,Wu
R1264 T1853 T1844 punct ;,Wu
R1265 T1854 T1844 nmod Lin,Wu
R1266 T1855 T1844 nmod et,Wu
R1267 T1856 T1844 nmod al.,Wu
R1268 T1857 T1844 nummod 2002,Wu
R1269 T1858 T1844 punct ),Wu
R1270 T1859 T1826 punct ", ",remained
R1271 T1860 T1826 oprd unchanged,remained
R1272 T1861 T1816 punct .,appear
R1273 T1863 T1864 compound Southern,blot
R1274 T1864 T1865 compound blot,analysis
R1275 T1865 T1866 nsubj analysis,detected
R1276 T1867 T1868 det a,number
R1277 T1868 T1866 dobj number,detected
R1278 T1869 T1870 advmod substantially,higher
R1279 T1870 T1868 amod higher,number
R1280 T1871 T1868 compound copy,number
R1281 T1872 T1868 prep of,number
R1282 T1873 T1874 det the,DNA
R1283 T1874 T1872 pobj DNA,of
R1284 T1875 T1874 amod mitochondrial,DNA
R1285 T1876 T1877 npadvmod genome,encoded
R1286 T1877 T1874 amod encoded,DNA
R1287 T1878 T1877 punct –,encoded
R1288 T1879 T1874 compound COXII,DNA
R1289 T1880 T1866 prep in,detected
R1290 T1881 T1882 det the,mice
R1291 T1882 T1880 pobj mice,in
R1292 T1883 T1882 amod transgenic,mice
R1293 T1884 T1885 punct (,Figure
R1294 T1885 T1866 parataxis Figure,detected
R1295 T1886 T1885 nummod 3B,Figure
R1296 T1887 T1885 punct ),Figure
R1297 T1888 T1866 punct .,detected
R1298 T1890 T1891 amod Mitochondrial,DNA
R1299 T1891 T1892 nsubjpass DNA,increased
R1300 T1893 T1892 auxpass was,increased
R1301 T1894 T1892 advmod 2.3,increased
R1302 T1895 T1894 punct -,2.3
R1303 T1896 T1894 advmod fold,2.3
R1304 T1897 T1892 prep in,increased
R1305 T1898 T1899 compound gastrocnemius,muscle
R1306 T1899 T1897 pobj muscle,in
R1307 T1900 T1899 prep of,muscle
R1308 T1901 T1902 det the,mice
R1309 T1902 T1900 pobj mice,of
R1310 T1903 T1902 amod transgenic,mice
R1311 T1904 T1905 punct (,Figure
R1312 T1905 T1892 parataxis Figure,increased
R1313 T1906 T1905 nummod 3C,Figure
R1314 T1907 T1905 punct ),Figure
R1315 T1908 T1892 punct .,increased
R1316 T1910 T1911 det These,results
R1317 T1911 T1912 nsubj results,reveal
R1318 T1913 T1914 det a,stimulation
R1319 T1914 T1912 dobj stimulation,reveal
R1320 T1915 T1914 amod marked,stimulation
R1321 T1916 T1914 prep of,stimulation
R1322 T1917 T1918 amod mitochondrial,biogenesis
R1323 T1918 T1916 pobj biogenesis,of
R1324 T1919 T1912 cc and,reveal
R1325 T1920 T1921 advmod further,support
R1326 T1921 T1912 conj support,reveal
R1327 T1922 T1923 det the,idea
R1328 T1923 T1921 dobj idea,support
R1329 T1924 T1925 mark that,is
R1330 T1925 T1923 acl is,idea
R1331 T1926 T1925 expl there,is
R1332 T1927 T1928 det a,switch
R1333 T1928 T1925 attr switch,is
R1334 T1929 T1930 compound muscle,fiber
R1335 T1930 T1928 compound fiber,switch
R1336 T1931 T1912 punct .,reveal
R1337 T1933 T1934 det This,conclusion
R1338 T1934 T1935 nsubjpass conclusion,confirmed
R1339 T1936 T1935 auxpass was,confirmed
R1340 T1937 T1935 advmod also,confirmed
R1341 T1938 T1935 prep by,confirmed
R1342 T1939 T1940 compound Western,blot
R1343 T1940 T1941 compound blot,analysis
R1344 T1941 T1938 pobj analysis,by
R1345 T1942 T1935 punct .,confirmed
R1346 T1944 T1945 mark As,shown
R1347 T1945 T1946 advcl shown,increased
R1348 T1947 T1945 prep in,shown
R1349 T1948 T1947 pobj Figure,in
R1350 T1949 T1948 nummod 3D,Figure
R1351 T1950 T1946 punct ", ",increased
R1352 T1951 T1952 det the,proteins
R1353 T1952 T1946 nsubjpass proteins,increased
R1354 T1953 T1952 amod characteristic,proteins
R1355 T1954 T1955 nmod type,fiber
R1356 T1955 T1952 compound fiber,proteins
R1357 T1956 T1954 nummod I,type
R1358 T1957 T1952 punct ", ",proteins
R1359 T1958 T1959 amod such,as
R1360 T1959 T1952 prep as,proteins
R1361 T1960 T1959 pobj myoglobin,as
R1362 T1961 T1960 cc and,myoglobin
R1363 T1962 T1963 nmod cytochrome,b
R1364 T1963 T1960 conj b,myoglobin
R1365 T1964 T1963 nmod c,b
R1366 T1965 T1964 cc and,c
R1367 T1966 T1946 punct ", ",increased
R1368 T1967 T1946 auxpass were,increased
R1369 T1968 T1946 advmod significantly,increased
R1370 T1969 T1946 punct .,increased
R1371 T1971 T1972 advmod More,importantly
R1372 T1972 T1973 advmod importantly,induced
R1373 T1973 T1990 ccomp induced,accompanied
R1374 T1974 T1973 punct ", ",induced
R1375 T1975 T1976 det the,protein
R1376 T1976 T1973 nsubjpass protein,induced
R1377 T1977 T1976 amod specialized,protein
R1378 T1978 T1976 compound contraction,protein
R1379 T1979 T1976 appos troponin,protein
R1380 T1980 T1979 nummod I,troponin
R1381 T1981 T1982 punct (,slow
R1382 T1982 T1976 parataxis slow,protein
R1383 T1983 T1982 punct ),slow
R1384 T1984 T1976 prep of,protein
R1385 T1985 T1986 nmod type,fiber
R1386 T1986 T1984 pobj fiber,of
R1387 T1987 T1985 nummod I,type
R1388 T1988 T1973 auxpass was,induced
R1389 T1989 T1973 advmod robustly,induced
R1390 T1991 T1990 punct ;,accompanied
R1391 T1992 T1990 nsubjpass this,accompanied
R1392 T1993 T1990 auxpass was,accompanied
R1393 T1994 T1990 agent by,accompanied
R1394 T1995 T1996 det a,reduction
R1395 T1996 T1994 pobj reduction,by
R1396 T1997 T1996 amod marked,reduction
R1397 T1998 T1996 prep of,reduction
R1398 T1999 T2000 det the,protein
R1399 T2000 T1998 pobj protein,of
R1400 T2001 T2000 amod specialized,protein
R1401 T2002 T2000 compound contraction,protein
R1402 T2003 T2000 appos troponin,protein
R1403 T2004 T2003 nummod I,troponin
R1404 T2005 T2006 punct (,fast
R1405 T2006 T2003 parataxis fast,troponin
R1406 T2007 T2006 punct ),fast
R1407 T2008 T2000 prep of,protein
R1408 T2009 T2010 nmod type,fiber
R1409 T2010 T2008 pobj fiber,of
R1410 T2011 T2009 nummod II,type
R1411 T2012 T1990 punct ", ",accompanied
R1412 T2013 T1990 advcl indicating,accompanied
R1413 T2014 T2015 det a,degree
R1414 T2015 T2013 dobj degree,indicating
R1415 T2016 T2015 amod high,degree
R1416 T2017 T2015 prep of,degree
R1417 T2018 T2019 compound fiber,transformation
R1418 T2019 T2017 pobj transformation,of
R1419 T2020 T1990 punct .,accompanied
R1420 T2022 T2023 nsubj We,examined
R1421 T2024 T2023 advmod next,examined
R1422 T2025 T2026 mark whether,induce
R1423 T2026 T2023 ccomp induce,examined
R1424 T2027 T2028 amod acute,activation
R1425 T2028 T2026 nsubj activation,induce
R1426 T2029 T2028 prep of,activation
R1427 T2030 T2031 amod endogenous,PPARδ
R1428 T2031 T2029 pobj PPARδ,of
R1429 T2032 T2026 aux would,induce
R1430 T2033 T2034 amod similar,genes
R1431 T2034 T2026 dobj genes,induce
R1432 T2035 T2034 compound target,genes
R1433 T2036 T2023 punct .,examined
R1434 T2038 T2039 prep In,found
R1435 T2040 T2038 pobj agreement,In
R1436 T2041 T2040 prep with,agreement
R1437 T2042 T2043 det the,effects
R1438 T2043 T2041 pobj effects,with
R1439 T2044 T2043 amod chronic,effects
R1440 T2045 T2043 prep in,effects
R1441 T2046 T2047 det the,mice
R1442 T2047 T2045 pobj mice,in
R1443 T2048 T2047 amod transgenic,mice
R1444 T2049 T2039 punct ", ",found
R1445 T2050 T2039 nsubj we,found
R1446 T2051 T2052 mark that,upregulated
R1447 T2052 T2039 ccomp upregulated,found
R1448 T2053 T2052 punct ", ",upregulated
R1449 T2054 T2052 prep after,upregulated
R1450 T2055 T2054 pobj treatment,after
R1451 T2056 T2055 prep of,treatment
R1452 T2057 T2058 amod wild,type
R1453 T2058 T2060 compound type,mice
R1454 T2059 T2058 punct -,type
R1455 T2060 T2056 pobj mice,of
R1456 T2061 T2060 compound C57B6J,mice
R1457 T2062 T2055 prep with,treatment
R1458 T2063 T2064 det the,GW501516
R1459 T2064 T2062 pobj GW501516,with
R1460 T2065 T2066 npadvmod PPARδ,specific
R1461 T2066 T2064 amod specific,GW501516
R1462 T2067 T2066 punct -,specific
R1463 T2068 T2064 compound agonist,GW501516
R1464 T2069 T2055 prep for,treatment
R1465 T2070 T2071 advmod only,d
R1466 T2071 T2069 pobj d,for
R1467 T2072 T2071 nummod 10,d
R1468 T2073 T2052 punct ", ",upregulated
R1469 T2074 T2052 nsubjpass genes,upregulated
R1470 T2075 T2074 prep for,genes
R1471 T2076 T2077 amod slow,fiber
R1472 T2077 T2078 nmod fiber,proteins
R1473 T2078 T2075 pobj proteins,for
R1474 T2079 T2078 amod contractile,proteins
R1475 T2080 T2078 punct ", ",proteins
R1476 T2081 T2082 amod mitochondrial,biogenesis
R1477 T2082 T2078 conj biogenesis,proteins
R1478 T2083 T2082 punct ", ",biogenesis
R1479 T2084 T2082 cc and,biogenesis
R1480 T2085 T2086 compound β,oxidation
R1481 T2086 T2082 conj oxidation,biogenesis
R1482 T2087 T2086 punct -,oxidation
R1483 T2088 T2052 auxpass were,upregulated
R1484 T2089 T2052 advmod all,upregulated
R1485 T2090 T2091 punct (,Figure
R1486 T2092 T2091 nummod 3E,Figure
R1487 T2091 T2052 parataxis Figure,upregulated
R1488 T2093 T2091 punct ),Figure
R1489 T2094 T2039 punct .,found
R1490 T2096 T2097 nsubj This,indicates
R1491 T2098 T2099 mark that,achieved
R1492 T2099 T2097 ccomp achieved,indicates
R1493 T2100 T2101 amod rapid,changes
R1494 T2101 T2099 nsubjpass changes,achieved
R1495 T2102 T2100 punct ", ",rapid
R1496 T2103 T2100 conj systematic,rapid
R1497 T2104 T2103 punct ", ",systematic
R1498 T2105 T2103 cc and,systematic
R1499 T2106 T2103 conj coordinated,systematic
R1500 T2107 T2101 prep of,changes
R1501 T2108 T2109 compound muscle,properties
R1502 T2109 T2107 pobj properties,of
R1503 T2110 T2109 compound fiber,properties
R1504 T2111 T2101 prep toward,changes
R1505 T2112 T2111 pobj type,toward
R1506 T2113 T2112 nummod I,type
R1507 T2114 T2099 aux can,achieved
R1508 T2115 T2099 auxpass be,achieved
R1509 T2116 T2099 prep by,achieved
R1510 T2117 T2116 pobj activation,by
R1511 T2118 T2117 prep of,activation
R1512 T2119 T2120 det the,pathway
R1513 T2120 T2118 pobj pathway,of
R1514 T2121 T2120 amod endogenous,pathway
R1515 T2122 T2120 compound PPARδ,pathway
R1516 T2123 T2097 punct .,indicates