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PMC:509410 / 4242-10852 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1279 0-10 NN denotes Activation
T1281 11-13 IN denotes of
T1282 14-19 NN denotes PPARδ
T1280 20-25 VBZ denotes Leads
T1283 26-28 IN denotes to
T1284 29-35 NN denotes Muscle
T1285 36-41 NN denotes Fiber
T1286 42-56 NN denotes Transformation
T1287 56-227 sentence denotes A role of PPARδ in muscle fiber was suggested by its enhanced expression—at levels 10-fold and 50-fold greater than PPARα and γ isoforms, respectively (unpublished data).
T1288 57-58 DT denotes A
T1289 59-63 NN denotes role
T1291 64-66 IN denotes of
T1292 67-72 NN denotes PPARδ
T1293 73-75 IN denotes in
T1294 76-82 NN denotes muscle
T1295 83-88 NN denotes fiber
T1296 89-92 VBD denotes was
T1290 93-102 VBN denotes suggested
T1297 103-105 IN denotes by
T1298 106-109 PRP$ denotes its
T1300 110-118 VBN denotes enhanced
T1299 119-129 NN denotes expression
T1301 129-130 HYPH denotes —
T1302 130-132 IN denotes at
T1303 133-139 NNS denotes levels
T1304 140-142 CD denotes 10
T1306 142-143 HYPH denotes -
T1307 143-147 RB denotes fold
T1308 148-151 CC denotes and
T1309 152-154 CD denotes 50
T1310 154-155 HYPH denotes -
T1311 155-159 RB denotes fold
T1305 160-167 JJR denotes greater
T1312 168-172 IN denotes than
T1313 173-178 NN denotes PPARα
T1315 179-182 CC denotes and
T1316 183-184 SYM denotes γ
T1314 185-193 NNS denotes isoforms
T1317 193-195 , denotes ,
T1318 195-207 RB denotes respectively
T1319 208-209 -LRB- denotes (
T1321 209-220 JJ denotes unpublished
T1320 221-225 NNS denotes data
T1322 225-226 -RRB- denotes )
T1323 226-227 . denotes .
T1324 227-541 sentence denotes An examination of PPARδ in different muscle fibers reveals a significantly higher level in type I muscle (soleus) relative to type II–rich muscle (extensor digitorum longus) or type I and type II mixed muscle (gastrocnemius) (Figure 1A); this expression pattern closely resembles that of PGC-1α (Lin et al. 2002).
T1325 228-230 DT denotes An
T1326 231-242 NN denotes examination
T1328 243-245 IN denotes of
T1329 246-251 NN denotes PPARδ
T1330 252-254 IN denotes in
T1331 255-264 JJ denotes different
T1333 265-271 NN denotes muscle
T1332 272-278 NNS denotes fibers
T1327 279-286 VBZ denotes reveals
T1335 287-288 DT denotes a
T1337 289-302 RB denotes significantly
T1338 303-309 JJR denotes higher
T1336 310-315 NN denotes level
T1339 316-318 IN denotes in
T1340 319-323 NN denotes type
T1342 324-325 CD denotes I
T1341 326-332 NN denotes muscle
T1343 333-334 -LRB- denotes (
T1344 334-340 NN denotes soleus
T1345 340-341 -RRB- denotes )
T1346 342-350 JJ denotes relative
T1347 351-353 IN denotes to
T1348 354-358 NN denotes type
T1350 359-361 CD denotes II
T1351 361-362 HYPH denotes –
T1349 362-366 JJ denotes rich
T1352 367-373 NN denotes muscle
T1353 374-375 -LRB- denotes (
T1355 375-383 NN denotes extensor
T1356 384-393 NN denotes digitorum
T1354 394-400 NN denotes longus
T1357 400-401 -RRB- denotes )
T1358 402-404 CC denotes or
T1359 405-409 NN denotes type
T1361 410-411 CD denotes I
T1362 412-415 CC denotes and
T1363 416-420 NN denotes type
T1364 421-423 CD denotes II
T1365 424-429 JJ denotes mixed
T1360 430-436 NN denotes muscle
T1366 437-438 -LRB- denotes (
T1367 438-451 NN denotes gastrocnemius
T1368 451-452 -RRB- denotes )
T1369 453-454 -LRB- denotes (
T1370 454-460 NN denotes Figure
T1371 461-463 CD denotes 1A
T1372 463-464 -RRB- denotes )
T1373 464-465 , denotes ;
T1374 466-470 DT denotes this
T1376 471-481 NN denotes expression
T1375 482-489 NN denotes pattern
T1377 490-497 RB denotes closely
T1334 498-507 VBZ denotes resembles
T1378 508-512 DT denotes that
T1379 513-515 IN denotes of
T1380 516-519 NN denotes PGC
T1381 519-520 HYPH denotes -
T1382 520-522 CD denotes 1α
T1383 523-524 -LRB- denotes (
T1384 524-527 NNP denotes Lin
T1385 528-530 FW denotes et
T1386 531-534 FW denotes al.
T1387 535-539 CD denotes 2002
T1388 539-540 -RRB- denotes )
T1389 540-541 . denotes .
T1390 541-640 sentence denotes A similar pattern but with more pronounced differences was found at the protein level (Figure 1B).
T1391 542-543 DT denotes A
T1393 544-551 JJ denotes similar
T1392 552-559 NN denotes pattern
T1395 560-563 CC denotes but
T1396 564-568 IN denotes with
T1397 569-573 RBR denotes more
T1398 574-584 VBN denotes pronounced
T1399 585-596 NNS denotes differences
T1400 597-600 VBD denotes was
T1394 601-606 VBN denotes found
T1401 607-609 IN denotes at
T1402 610-613 DT denotes the
T1404 614-621 NN denotes protein
T1403 622-627 NN denotes level
T1405 628-629 -LRB- denotes (
T1406 629-635 NN denotes Figure
T1407 636-638 CD denotes 1B
T1408 638-639 -RRB- denotes )
T1409 639-640 . denotes .
T1410 640-1844 sentence denotes Figure 1 Expression of Endogenous PPARδ and VP16-PPARδ Transgene in Muscle (A) Pooled RNA isolated from various muscles of five wild-type male C57B6 mice was hybridized with indicated probes. EDL, extensor digitorum longus; Gastro, gastrocnemius. (B) Pooled nuclear proteins (15 μg/lane) isolated from muscles of five wild-type male C57B6 were probed with anti-PPARδ antibody. RNA polymerase II (Pol II) is shown as a loading control. (C) Expression of the VP16-PPARδ transgene in various tissues. 10 μg of total RNA from each tissue was hybridized with a VP16 cDNA probe. Gastrocnemius muscle was used here. (D) Nuclear proteins (15 μg/lane) isolated from gastrocnemius muscle of the transgenic mice (TG) and the wild-type littermates (WT) were probed with indicated antibodies. The upper, nonspecific band that cross-reacted with the anti-PPARδ antibody serves a loading control. To directly assess the role of activation of PPARδ in control of muscle fiber plasticity and mitochondrial biogenesis, we generated mice expressing a transgene in which the 78-amino-acid VP16 activation domain was fused to the N-terminus of full-length PPARδ, under control of the 2.2-kb human α-skeletal actin promoter.
T4687 651-661 NN denotes Expression
T4688 662-664 IN denotes of
T4689 665-675 JJ denotes Endogenous
T4691 676-681 NN denotes PPARδ
T4692 682-685 CC denotes and
T4693 686-690 NN denotes VP16
T4695 690-691 HYPH denotes -
T4694 691-696 NN denotes PPARδ
T4690 697-706 NN denotes Transgene
T4696 707-709 IN denotes in
T4697 710-716 NN denotes Muscle
T4698 716-833 sentence denotes (A) Pooled RNA isolated from various muscles of five wild-type male C57B6 mice was hybridized with indicated probes.
T4699 717-718 -LRB- denotes (
T4700 718-719 LS denotes A
T4702 719-720 -RRB- denotes )
T4703 721-727 VBN denotes Pooled
T4704 728-731 NN denotes RNA
T4705 732-740 VBN denotes isolated
T4706 741-745 IN denotes from
T4707 746-753 JJ denotes various
T4708 754-761 NNS denotes muscles
T4709 762-764 IN denotes of
T4710 765-769 CD denotes five
T4712 770-774 JJ denotes wild
T4714 774-775 HYPH denotes -
T4713 775-779 NN denotes type
T4715 780-784 JJ denotes male
T4716 785-790 NN denotes C57B6
T4711 791-795 NNS denotes mice
T4717 796-799 VBD denotes was
T4701 800-810 VBN denotes hybridized
T4718 811-815 IN denotes with
T4719 816-825 VBN denotes indicated
T4720 826-832 NNS denotes probes
T4721 832-833 . denotes .
T4722 833-888 sentence denotes EDL, extensor digitorum longus; Gastro, gastrocnemius.
T4723 834-837 NN denotes EDL
T4724 837-839 , denotes ,
T4725 839-847 NN denotes extensor
T4727 848-857 NN denotes digitorum
T4726 858-864 NN denotes longus
T4728 864-865 , denotes ;
T4729 866-872 NN denotes Gastro
T4730 872-874 , denotes ,
T4731 874-887 NN denotes gastrocnemius
T4732 887-888 . denotes .
T4733 888-1018 sentence denotes (B) Pooled nuclear proteins (15 μg/lane) isolated from muscles of five wild-type male C57B6 were probed with anti-PPARδ antibody.
T4734 889-890 -LRB- denotes (
T4735 890-891 LS denotes B
T4737 891-892 -RRB- denotes )
T4738 893-899 VBN denotes Pooled
T4740 900-907 JJ denotes nuclear
T4739 908-916 NN denotes proteins
T4741 917-918 -LRB- denotes (
T4743 918-920 CD denotes 15
T4742 921-923 NNS denotes μg
T4744 923-924 SYM denotes /
T4745 924-928 NN denotes lane
T4746 928-929 -RRB- denotes )
T4747 930-938 VBN denotes isolated
T4748 939-943 IN denotes from
T4749 944-951 NNS denotes muscles
T4750 952-954 IN denotes of
T4751 955-959 CD denotes five
T4753 960-964 JJ denotes wild
T4755 964-965 HYPH denotes -
T4754 965-969 NN denotes type
T4756 970-974 JJ denotes male
T4752 975-980 NN denotes C57B6
T4757 981-985 VBD denotes were
T4736 986-992 VBN denotes probed
T4758 993-997 IN denotes with
T4759 998-1008 JJ denotes anti-PPARδ
T4760 1009-1017 NN denotes antibody
T4761 1017-1018 . denotes .
T4762 1018-1076 sentence denotes RNA polymerase II (Pol II) is shown as a loading control.
T4763 1019-1022 NN denotes RNA
T4764 1023-1033 NN denotes polymerase
T4766 1034-1036 CD denotes II
T4767 1037-1038 -LRB- denotes (
T4768 1038-1041 NN denotes Pol
T4769 1042-1044 CD denotes II
T4770 1044-1045 -RRB- denotes )
T4771 1046-1048 VBZ denotes is
T4765 1049-1054 VBN denotes shown
T4772 1055-1057 IN denotes as
T4773 1058-1059 DT denotes a
T4775 1060-1067 NN denotes loading
T4774 1068-1075 NN denotes control
T4776 1075-1076 . denotes .
T4777 1076-1139 sentence denotes (C) Expression of the VP16-PPARδ transgene in various tissues.
T4778 1077-1078 -LRB- denotes (
T4779 1078-1079 LS denotes C
T4781 1079-1080 -RRB- denotes )
T4780 1081-1091 NN denotes Expression
T4782 1092-1094 IN denotes of
T4783 1095-1098 DT denotes the
T4785 1099-1103 NN denotes VP16
T4787 1103-1104 HYPH denotes -
T4786 1104-1109 NN denotes PPARδ
T4784 1110-1119 NN denotes transgene
T4788 1120-1122 IN denotes in
T4789 1123-1130 JJ denotes various
T4790 1131-1138 NNS denotes tissues
T4791 1138-1139 . denotes .
T4792 1139-1214 sentence denotes 10 μg of total RNA from each tissue was hybridized with a VP16 cDNA probe.
T4793 1140-1142 CD denotes 10
T4794 1143-1145 NNS denotes μg
T4796 1146-1148 IN denotes of
T4797 1149-1154 JJ denotes total
T4798 1155-1158 NN denotes RNA
T4799 1159-1163 IN denotes from
T4800 1164-1168 DT denotes each
T4801 1169-1175 NN denotes tissue
T4802 1176-1179 VBD denotes was
T4795 1180-1190 VBN denotes hybridized
T4803 1191-1195 IN denotes with
T4804 1196-1197 DT denotes a
T4806 1198-1202 NN denotes VP16
T4807 1203-1207 NN denotes cDNA
T4805 1208-1213 NN denotes probe
T4808 1213-1214 . denotes .
T4809 1214-1250 sentence denotes Gastrocnemius muscle was used here.
T4810 1215-1228 NN denotes Gastrocnemius
T4811 1229-1235 NN denotes muscle
T4813 1236-1239 VBD denotes was
T4812 1240-1244 VBN denotes used
T4814 1245-1249 RB denotes here
T4815 1249-1250 . denotes .
T4816 1250-1421 sentence denotes (D) Nuclear proteins (15 μg/lane) isolated from gastrocnemius muscle of the transgenic mice (TG) and the wild-type littermates (WT) were probed with indicated antibodies.
T4817 1251-1252 -LRB- denotes (
T4818 1252-1253 LS denotes D
T4820 1253-1254 -RRB- denotes )
T4821 1255-1262 JJ denotes Nuclear
T4822 1263-1271 NN denotes proteins
T4823 1272-1273 -LRB- denotes (
T4825 1273-1275 CD denotes 15
T4824 1276-1278 NNS denotes μg
T4826 1278-1279 SYM denotes /
T4827 1279-1283 NN denotes lane
T4828 1283-1284 -RRB- denotes )
T4829 1285-1293 VBN denotes isolated
T4830 1294-1298 IN denotes from
T4831 1299-1312 NN denotes gastrocnemius
T4832 1313-1319 NN denotes muscle
T4833 1320-1322 IN denotes of
T4834 1323-1326 DT denotes the
T4836 1327-1337 JJ denotes transgenic
T4835 1338-1342 NNS denotes mice
T4837 1343-1344 -LRB- denotes (
T4838 1344-1346 JJ denotes TG
T4839 1346-1347 -RRB- denotes )
T4840 1348-1351 CC denotes and
T4841 1352-1355 DT denotes the
T4843 1356-1360 JJ denotes wild
T4845 1360-1361 HYPH denotes -
T4844 1361-1365 NN denotes type
T4842 1366-1377 NNS denotes littermates
T4846 1378-1379 -LRB- denotes (
T4847 1379-1381 NN denotes WT
T4848 1381-1382 -RRB- denotes )
T4849 1383-1387 VBD denotes were
T4819 1388-1394 VBN denotes probed
T4850 1395-1399 IN denotes with
T4851 1400-1409 JJ denotes indicated
T4852 1410-1420 NNS denotes antibodies
T4853 1420-1421 . denotes .
T4854 1421-1523 sentence denotes The upper, nonspecific band that cross-reacted with the anti-PPARδ antibody serves a loading control.
T4855 1422-1425 DT denotes The
T4857 1426-1431 JJ denotes upper
T4858 1431-1433 , denotes ,
T4859 1433-1444 JJ denotes nonspecific
T4856 1445-1449 NN denotes band
T4861 1450-1454 WDT denotes that
T4862 1455-1468 VBD denotes cross-reacted
T4863 1469-1473 IN denotes with
T4864 1474-1477 DT denotes the
T4866 1478-1488 JJ denotes anti-PPARδ
T4865 1489-1497 NN denotes antibody
T4860 1498-1504 VBZ denotes serves
T4867 1505-1506 DT denotes a
T4869 1507-1514 NN denotes loading
T4868 1515-1522 NN denotes control
T4870 1522-1523 . denotes .
T1411 1524-1526 TO denotes To
T1413 1527-1535 RB denotes directly
T1412 1536-1542 VB denotes assess
T1415 1543-1546 DT denotes the
T1416 1547-1551 NN denotes role
T1417 1552-1554 IN denotes of
T1418 1555-1565 NN denotes activation
T1419 1566-1568 IN denotes of
T1420 1569-1574 NN denotes PPARδ
T1421 1575-1577 IN denotes in
T1422 1578-1585 NN denotes control
T1423 1586-1588 IN denotes of
T1424 1589-1595 NN denotes muscle
T1425 1596-1601 NN denotes fiber
T1426 1602-1612 NN denotes plasticity
T1427 1613-1616 CC denotes and
T1428 1617-1630 JJ denotes mitochondrial
T1429 1631-1641 NN denotes biogenesis
T1430 1641-1643 , denotes ,
T1431 1643-1645 PRP denotes we
T1414 1646-1655 VBD denotes generated
T1432 1656-1660 NNS denotes mice
T1433 1661-1671 VBG denotes expressing
T1434 1672-1673 DT denotes a
T1435 1674-1683 NN denotes transgene
T1436 1684-1686 IN denotes in
T1438 1687-1692 WDT denotes which
T1439 1693-1696 DT denotes the
T1441 1697-1699 CD denotes 78
T1443 1699-1700 HYPH denotes -
T1444 1700-1705 NN denotes amino
T1445 1705-1706 HYPH denotes -
T1442 1706-1710 NN denotes acid
T1446 1711-1715 NN denotes VP16
T1447 1716-1726 NN denotes activation
T1440 1727-1733 NN denotes domain
T1448 1734-1737 VBD denotes was
T1437 1738-1743 VBN denotes fused
T1449 1744-1746 IN denotes to
T1450 1747-1750 DT denotes the
T1452 1751-1752 NN denotes N
T1453 1752-1753 HYPH denotes -
T1451 1753-1761 NN denotes terminus
T1454 1762-1764 IN denotes of
T1455 1765-1769 JJ denotes full
T1457 1769-1770 HYPH denotes -
T1456 1770-1776 NN denotes length
T1458 1777-1782 NN denotes PPARδ
T1459 1782-1784 , denotes ,
T1460 1784-1789 IN denotes under
T1461 1790-1797 NN denotes control
T1462 1798-1800 IN denotes of
T1463 1801-1804 DT denotes the
T1465 1805-1808 CD denotes 2.2
T1467 1808-1809 HYPH denotes -
T1466 1809-1811 NN denotes kb
T1468 1812-1817 JJ denotes human
T1469 1818-1819 NN denotes α
T1471 1819-1820 HYPH denotes -
T1470 1820-1828 JJ denotes skeletal
T1472 1829-1834 NN denotes actin
T1464 1835-1843 NN denotes promoter
T1473 1843-1844 . denotes .
T1474 1844-2074 sentence denotes In agreement with the previous characterization of this promoter (Brennan and Hardeman 1993; Clapham et al. 2000), the VP16-PPARδ transgene was selectively expressed in skeletal muscle, with 10-fold less in the heart (Figure 1C).
T1475 1845-1847 IN denotes In
T1477 1848-1857 NN denotes agreement
T1478 1858-1862 IN denotes with
T1479 1863-1866 DT denotes the
T1481 1867-1875 JJ denotes previous
T1480 1876-1892 NN denotes characterization
T1482 1893-1895 IN denotes of
T1483 1896-1900 DT denotes this
T1484 1901-1909 NN denotes promoter
T1485 1910-1911 -LRB- denotes (
T1486 1911-1918 NNP denotes Brennan
T1487 1919-1922 CC denotes and
T1488 1923-1931 NNP denotes Hardeman
T1489 1932-1936 CD denotes 1993
T1490 1936-1937 : denotes ;
T1491 1938-1945 NNP denotes Clapham
T1492 1946-1948 FW denotes et
T1493 1949-1952 FW denotes al.
T1494 1953-1957 CD denotes 2000
T1495 1957-1958 -RRB- denotes )
T1496 1958-1960 , denotes ,
T1497 1960-1963 DT denotes the
T1499 1964-1968 NN denotes VP16
T1501 1968-1969 HYPH denotes -
T1500 1969-1974 NN denotes PPARδ
T1498 1975-1984 NN denotes transgene
T1502 1985-1988 VBD denotes was
T1503 1989-2000 RB denotes selectively
T1476 2001-2010 VBN denotes expressed
T1504 2011-2013 IN denotes in
T1505 2014-2022 JJ denotes skeletal
T1506 2023-2029 NN denotes muscle
T1507 2029-2031 , denotes ,
T1508 2031-2035 IN denotes with
T1510 2036-2038 CD denotes 10
T1511 2038-2039 HYPH denotes -
T1512 2039-2043 RB denotes fold
T1509 2044-2048 JJR denotes less
T1513 2049-2051 IN denotes in
T1514 2052-2055 DT denotes the
T1515 2056-2061 NN denotes heart
T1516 2062-2063 -LRB- denotes (
T1517 2063-2069 NN denotes Figure
T1518 2070-2072 CD denotes 1C
T1519 2072-2073 -RRB- denotes )
T1520 2073-2074 . denotes .
T1521 2074-2193 sentence denotes Among different types of muscle fibers, the levels of VP16-PPARδ expression appeared to be similar (unpublished data).
T1522 2075-2080 IN denotes Among
T1524 2081-2090 JJ denotes different
T1525 2091-2096 NNS denotes types
T1526 2097-2099 IN denotes of
T1527 2100-2106 NN denotes muscle
T1528 2107-2113 NNS denotes fibers
T1529 2113-2115 , denotes ,
T1530 2115-2118 DT denotes the
T1531 2119-2125 NNS denotes levels
T1532 2126-2128 IN denotes of
T1533 2129-2133 NN denotes VP16
T1535 2133-2134 HYPH denotes -
T1534 2134-2139 NN denotes PPARδ
T1536 2140-2150 NN denotes expression
T1523 2151-2159 VBD denotes appeared
T1537 2160-2162 TO denotes to
T1538 2163-2165 VB denotes be
T1539 2166-2173 JJ denotes similar
T1540 2174-2175 -LRB- denotes (
T1542 2175-2186 JJ denotes unpublished
T1541 2187-2191 NNS denotes data
T1543 2191-2192 -RRB- denotes )
T1544 2192-2193 . denotes .
T1545 2193-2353 sentence denotes As shown in Figure 1D for gastrocnemius muscle, VP16-PPARδ fusion protein was produced at a level similar to that of endogenous PPARδ in wild-type littermates.
T1546 2194-2196 IN denotes As
T1547 2197-2202 VBN denotes shown
T1549 2203-2205 IN denotes in
T1550 2206-2212 NN denotes Figure
T1551 2213-2215 CD denotes 1D
T1552 2216-2219 IN denotes for
T1553 2220-2233 NN denotes gastrocnemius
T1554 2234-2240 NN denotes muscle
T1555 2240-2242 , denotes ,
T1556 2242-2246 NN denotes VP16
T1558 2246-2247 HYPH denotes -
T1557 2247-2252 NN denotes PPARδ
T1560 2253-2259 NN denotes fusion
T1559 2260-2267 NN denotes protein
T1561 2268-2271 VBD denotes was
T1548 2272-2280 VBN denotes produced
T1562 2281-2283 IN denotes at
T1563 2284-2285 DT denotes a
T1564 2286-2291 NN denotes level
T1565 2292-2299 JJ denotes similar
T1566 2300-2302 IN denotes to
T1567 2303-2307 DT denotes that
T1568 2308-2310 IN denotes of
T1569 2311-2321 JJ denotes endogenous
T1570 2322-2327 NN denotes PPARδ
T1571 2328-2330 IN denotes in
T1572 2331-2335 JJ denotes wild
T1574 2335-2336 HYPH denotes -
T1573 2336-2340 NN denotes type
T1575 2341-2352 NNS denotes littermates
T1576 2352-2353 . denotes .
T1577 2353-2485 sentence denotes Interestingly, the level of endogenous muscle PPARδ protein in the transgenic mice was much higher than in the control littermates.
T1578 2354-2367 RB denotes Interestingly
T1580 2367-2369 , denotes ,
T1581 2369-2372 DT denotes the
T1582 2373-2378 NN denotes level
T1583 2379-2381 IN denotes of
T1584 2382-2392 JJ denotes endogenous
T1586 2393-2399 NN denotes muscle
T1587 2400-2405 NN denotes PPARδ
T1585 2406-2413 NN denotes protein
T1588 2414-2416 IN denotes in
T1589 2417-2420 DT denotes the
T1591 2421-2431 JJ denotes transgenic
T1590 2432-2436 NNS denotes mice
T1579 2437-2440 VBD denotes was
T1592 2441-2445 RB denotes much
T1593 2446-2452 JJR denotes higher
T1594 2453-2457 IN denotes than
T1595 2458-2460 IN denotes in
T1596 2461-2464 DT denotes the
T1598 2465-2472 NN denotes control
T1597 2473-2484 NNS denotes littermates
T1599 2484-2485 . denotes .
T1600 2485-2665 sentence denotes The substantial increase of endogenous PPARδ may have been caused by a switch to type I fiber (see below), which intrinsically expresses higher levels of PPARδ (Figure 1A and 1B).
T1601 2486-2489 DT denotes The
T1603 2490-2501 JJ denotes substantial
T1602 2502-2510 NN denotes increase
T1605 2511-2513 IN denotes of
T1606 2514-2524 JJ denotes endogenous
T1607 2525-2530 NN denotes PPARδ
T1608 2531-2534 MD denotes may
T1609 2535-2539 VB denotes have
T1610 2540-2544 VBN denotes been
T1604 2545-2551 VBN denotes caused
T1611 2552-2554 IN denotes by
T1612 2555-2556 DT denotes a
T1613 2557-2563 NN denotes switch
T1614 2564-2566 IN denotes to
T1615 2567-2571 NN denotes type
T1617 2572-2573 CD denotes I
T1616 2574-2579 NN denotes fiber
T1618 2580-2581 -LRB- denotes (
T1619 2581-2584 VB denotes see
T1620 2585-2590 RB denotes below
T1621 2590-2591 -RRB- denotes )
T1622 2591-2593 , denotes ,
T1623 2593-2598 WDT denotes which
T1625 2599-2612 RB denotes intrinsically
T1624 2613-2622 VBZ denotes expresses
T1626 2623-2629 JJR denotes higher
T1627 2630-2636 NNS denotes levels
T1628 2637-2639 IN denotes of
T1629 2640-2645 NN denotes PPARδ
T1630 2646-2647 -LRB- denotes (
T1632 2647-2653 NN denotes Figure
T1631 2654-2656 CD denotes 1A
T1633 2657-2660 CC denotes and
T1634 2661-2663 CD denotes 1B
T1635 2663-2664 -RRB- denotes )
T1636 2664-2665 . denotes .
T1637 2665-2861 sentence denotes Type I muscle can be readily distinguished from type II or mixed muscle by its red color, because of its high concentration of myoglobin, a protein typically expressed in oxidative muscle fibers.
T1638 2666-2670 NN denotes Type
T1640 2671-2672 CD denotes I
T1639 2673-2679 NN denotes muscle
T1642 2680-2683 MD denotes can
T1643 2684-2686 VB denotes be
T1644 2687-2694 RB denotes readily
T1641 2695-2708 VBN denotes distinguished
T1645 2709-2713 IN denotes from
T1646 2714-2718 NN denotes type
T1648 2719-2721 CD denotes II
T1649 2722-2724 CC denotes or
T1650 2725-2730 VBN denotes mixed
T1647 2731-2737 NN denotes muscle
T1651 2738-2740 IN denotes by
T1652 2741-2744 PRP$ denotes its
T1654 2745-2748 JJ denotes red
T1653 2749-2754 NN denotes color
T1655 2754-2756 , denotes ,
T1656 2756-2763 IN denotes because
T1657 2764-2766 IN denotes of
T1658 2767-2770 PRP$ denotes its
T1660 2771-2775 JJ denotes high
T1659 2776-2789 NN denotes concentration
T1661 2790-2792 IN denotes of
T1662 2793-2802 NN denotes myoglobin
T1663 2802-2804 , denotes ,
T1664 2804-2805 DT denotes a
T1665 2806-2813 NN denotes protein
T1666 2814-2823 RB denotes typically
T1667 2824-2833 VBN denotes expressed
T1668 2834-2836 IN denotes in
T1669 2837-2846 JJ denotes oxidative
T1671 2847-2853 NN denotes muscle
T1670 2854-2860 NNS denotes fibers
T1672 2860-2861 . denotes .
T1673 2861-3024 sentence denotes We found that muscles in the transgenic mice appeared redder (Figure 2A), which is particularly evident in the mixed type I/II fibers of the hindlimb (Figure 2B).
T1674 2862-2864 PRP denotes We
T1675 2865-2870 VBD denotes found
T1676 2871-2875 IN denotes that
T1678 2876-2883 NNS denotes muscles
T1679 2884-2886 IN denotes in
T1680 2887-2890 DT denotes the
T1682 2891-2901 JJ denotes transgenic
T1681 2902-2906 NNS denotes mice
T1677 2907-2915 VBD denotes appeared
T1683 2916-2922 JJR denotes redder
T1684 2923-2924 -LRB- denotes (
T1685 2924-2930 NN denotes Figure
T1686 2931-2933 CD denotes 2A
T1687 2933-2934 -RRB- denotes )
T1688 2934-2936 , denotes ,
T1689 2936-2941 WDT denotes which
T1690 2942-2944 VBZ denotes is
T1691 2945-2957 RB denotes particularly
T1692 2958-2965 JJ denotes evident
T1693 2966-2968 IN denotes in
T1694 2969-2972 DT denotes the
T1696 2973-2978 JJ denotes mixed
T1698 2979-2983 NN denotes type
T1699 2984-2985 CD denotes I
T1700 2985-2986 HYPH denotes /
T1697 2986-2988 CD denotes II
T1695 2989-2995 NNS denotes fibers
T1701 2996-2998 IN denotes of
T1702 2999-3002 DT denotes the
T1703 3003-3011 NN denotes hindlimb
T1704 3012-3013 -LRB- denotes (
T1705 3013-3019 NN denotes Figure
T1706 3020-3022 CD denotes 2B
T1707 3022-3023 -RRB- denotes )
T1708 3023-3024 . denotes .
T1709 3024-3119 sentence denotes Indeed, metachromatic staining revealed a substantial muscle fiber transformation (Figure 2C).
T1710 3025-3031 RB denotes Indeed
T1712 3031-3033 , denotes ,
T1713 3033-3046 JJ denotes metachromatic
T1714 3047-3055 NN denotes staining
T1711 3056-3064 VBD denotes revealed
T1715 3065-3066 DT denotes a
T1717 3067-3078 JJ denotes substantial
T1718 3079-3085 NN denotes muscle
T1719 3086-3091 NN denotes fiber
T1716 3092-3106 NN denotes transformation
T1720 3107-3108 -LRB- denotes (
T1721 3108-3114 NN denotes Figure
T1722 3115-3117 CD denotes 2C
T1723 3117-3118 -RRB- denotes )
T1724 3118-3119 . denotes .
T1725 3119-3208 sentence denotes In gastrocnemius muscle, we estimated that there was a 2-fold increase of type I fibers.
T1726 3120-3122 IN denotes In
T1728 3123-3136 NN denotes gastrocnemius
T1729 3137-3143 NN denotes muscle
T1730 3143-3145 , denotes ,
T1731 3145-3147 PRP denotes we
T1727 3148-3157 VBD denotes estimated
T1732 3158-3162 IN denotes that
T1734 3163-3168 EX denotes there
T1733 3169-3172 VBD denotes was
T1735 3173-3174 DT denotes a
T1737 3175-3181 JJ denotes 2-fold
T1736 3182-3190 NN denotes increase
T1738 3191-3193 IN denotes of
T1739 3194-3198 NN denotes type
T1741 3199-3200 CD denotes I
T1740 3201-3207 NNS denotes fibers
T1742 3207-3208 . denotes .
T1743 3208-3362 sentence denotes A diagnostic component of oxidative fibers is their high myoglobin and mitochondrial content, which is supported by the mRNA analysis shown in Figure 3A.
T1744 3209-3210 DT denotes A
T1746 3211-3221 JJ denotes diagnostic
T1745 3222-3231 NN denotes component
T1748 3232-3234 IN denotes of
T1749 3235-3244 JJ denotes oxidative
T1750 3245-3251 NNS denotes fibers
T1747 3252-3254 VBZ denotes is
T1751 3255-3260 PRP$ denotes their
T1753 3261-3265 JJ denotes high
T1754 3266-3275 NN denotes myoglobin
T1755 3276-3279 CC denotes and
T1756 3280-3293 JJ denotes mitochondrial
T1752 3294-3301 NN denotes content
T1757 3301-3303 , denotes ,
T1758 3303-3308 WDT denotes which
T1760 3309-3311 VBZ denotes is
T1759 3312-3321 VBN denotes supported
T1761 3322-3324 IN denotes by
T1762 3325-3328 DT denotes the
T1764 3329-3333 NN denotes mRNA
T1763 3334-3342 NN denotes analysis
T1765 3343-3348 VBN denotes shown
T1766 3349-3351 IN denotes in
T1767 3352-3358 NN denotes Figure
T1768 3359-3361 CD denotes 3A
T1769 3361-3362 . denotes .
T1770 3362-3571 sentence denotes In addition to myoglobin, mitochondrial components for electron transfer (cytochrome c and cytochrome c oxidase [COX] II and IV) and fatty-acid β-oxidation enzymes were elevated (Figure 3A; unpublished data).
T1771 3363-3365 IN denotes In
T1773 3366-3374 NN denotes addition
T1774 3375-3377 IN denotes to
T1775 3378-3387 NN denotes myoglobin
T1776 3387-3389 , denotes ,
T1777 3389-3402 JJ denotes mitochondrial
T1778 3403-3413 NNS denotes components
T1779 3414-3417 IN denotes for
T1780 3418-3426 NN denotes electron
T1781 3427-3435 NN denotes transfer
T1782 3436-3437 -LRB- denotes (
T1784 3437-3447 NN denotes cytochrome
T1783 3448-3449 NN denotes c
T1785 3450-3453 CC denotes and
T1786 3454-3464 NN denotes cytochrome
T1787 3465-3466 NN denotes c
T1788 3467-3474 NN denotes oxidase
T1789 3475-3476 -LRB- denotes [
T1790 3476-3479 NN denotes COX
T1791 3479-3480 -RRB- denotes ]
T1792 3481-3483 CD denotes II
T1793 3484-3487 CC denotes and
T1794 3488-3490 CD denotes IV
T1795 3490-3491 -RRB- denotes )
T1796 3492-3495 CC denotes and
T1797 3496-3501 JJ denotes fatty
T1799 3501-3502 HYPH denotes -
T1798 3502-3506 NN denotes acid
T1801 3507-3508 NN denotes β
T1803 3508-3509 HYPH denotes -
T1802 3509-3518 NN denotes oxidation
T1800 3519-3526 NNS denotes enzymes
T1804 3527-3531 VBD denotes were
T1772 3532-3540 VBN denotes elevated
T1805 3541-3542 -LRB- denotes (
T1807 3542-3548 NN denotes Figure
T1808 3549-3551 CD denotes 3A
T1809 3551-3552 : denotes ;
T1810 3553-3564 JJ denotes unpublished
T1806 3565-3569 NNS denotes data
T1811 3569-3570 -RRB- denotes )
T1812 3570-3571 . denotes .
T1813 3571-3810 sentence denotes These effects appear to be direct consequences of PPARδ activation, as levels of PGC-1α, a coactivator involved in muscle fiber switch and mitochondrial biogenesis (Wu et al. 1999; Lehman et al. 2000; Lin et al. 2002), remained unchanged.
T1814 3572-3577 DT denotes These
T1815 3578-3585 NNS denotes effects
T1816 3586-3592 VBP denotes appear
T1817 3593-3595 TO denotes to
T1818 3596-3598 VB denotes be
T1819 3599-3605 JJ denotes direct
T1820 3606-3618 NNS denotes consequences
T1821 3619-3621 IN denotes of
T1822 3622-3627 NN denotes PPARδ
T1823 3628-3638 NN denotes activation
T1824 3638-3640 , denotes ,
T1825 3640-3642 IN denotes as
T1827 3643-3649 NNS denotes levels
T1828 3650-3652 IN denotes of
T1829 3653-3656 NN denotes PGC
T1830 3656-3657 HYPH denotes -
T1831 3657-3659 CD denotes 1α
T1832 3659-3661 , denotes ,
T1833 3661-3662 DT denotes a
T1834 3663-3674 NN denotes coactivator
T1835 3675-3683 VBN denotes involved
T1836 3684-3686 IN denotes in
T1837 3687-3693 NN denotes muscle
T1838 3694-3699 NN denotes fiber
T1839 3700-3706 NN denotes switch
T1840 3707-3710 CC denotes and
T1841 3711-3724 JJ denotes mitochondrial
T1842 3725-3735 NN denotes biogenesis
T1843 3736-3737 -LRB- denotes (
T1844 3737-3739 NNP denotes Wu
T1845 3740-3742 FW denotes et
T1846 3743-3746 FW denotes al.
T1847 3747-3751 CD denotes 1999
T1848 3751-3752 : denotes ;
T1849 3753-3759 NNP denotes Lehman
T1850 3760-3762 FW denotes et
T1851 3763-3766 FW denotes al.
T1852 3767-3771 CD denotes 2000
T1853 3771-3772 : denotes ;
T1854 3773-3776 NNP denotes Lin
T1855 3777-3779 FW denotes et
T1856 3780-3783 FW denotes al.
T1857 3784-3788 CD denotes 2002
T1858 3788-3789 -RRB- denotes )
T1859 3789-3791 , denotes ,
T1826 3791-3799 VBD denotes remained
T1860 3800-3809 JJ denotes unchanged
T1861 3809-3810 . denotes .
T1862 3810-3959 sentence denotes Southern blot analysis detected a substantially higher copy number of the mitochondrial genome–encoded COXII DNA in the transgenic mice (Figure 3B).
T1863 3811-3819 NNP denotes Southern
T1864 3820-3824 NN denotes blot
T1865 3825-3833 NN denotes analysis
T1866 3834-3842 VBD denotes detected
T1867 3843-3844 DT denotes a
T1869 3845-3858 RB denotes substantially
T1870 3859-3865 JJR denotes higher
T1871 3866-3870 NN denotes copy
T1868 3871-3877 NN denotes number
T1872 3878-3880 IN denotes of
T1873 3881-3884 DT denotes the
T1875 3885-3898 JJ denotes mitochondrial
T1876 3899-3905 NN denotes genome
T1878 3905-3906 HYPH denotes –
T1877 3906-3913 VBN denotes encoded
T1879 3914-3919 NN denotes COXII
T1874 3920-3923 NN denotes DNA
T1880 3924-3926 IN denotes in
T1881 3927-3930 DT denotes the
T1883 3931-3941 JJ denotes transgenic
T1882 3942-3946 NNS denotes mice
T1884 3947-3948 -LRB- denotes (
T1885 3948-3954 NN denotes Figure
T1886 3955-3957 CD denotes 3B
T1887 3957-3958 -RRB- denotes )
T1888 3958-3959 . denotes .
T1889 3959-4060 sentence denotes Mitochondrial DNA was increased 2.3-fold in gastrocnemius muscle of the transgenic mice (Figure 3C).
T1890 3960-3973 JJ denotes Mitochondrial
T1891 3974-3977 NN denotes DNA
T1893 3978-3981 VBD denotes was
T1892 3982-3991 VBN denotes increased
T1894 3992-3995 CD denotes 2.3
T1895 3995-3996 HYPH denotes -
T1896 3996-4000 RB denotes fold
T1897 4001-4003 IN denotes in
T1898 4004-4017 NN denotes gastrocnemius
T1899 4018-4024 NN denotes muscle
T1900 4025-4027 IN denotes of
T1901 4028-4031 DT denotes the
T1903 4032-4042 JJ denotes transgenic
T1902 4043-4047 NNS denotes mice
T1904 4048-4049 -LRB- denotes (
T1905 4049-4055 NN denotes Figure
T1906 4056-4058 CD denotes 3C
T1907 4058-4059 -RRB- denotes )
T1908 4059-4060 . denotes .
T1909 4060-4196 sentence denotes These results reveal a marked stimulation of mitochondrial biogenesis and further support the idea that there is a muscle fiber switch.
T1910 4061-4066 DT denotes These
T1911 4067-4074 NNS denotes results
T1912 4075-4081 VBP denotes reveal
T1913 4082-4083 DT denotes a
T1915 4084-4090 JJ denotes marked
T1914 4091-4102 NN denotes stimulation
T1916 4103-4105 IN denotes of
T1917 4106-4119 JJ denotes mitochondrial
T1918 4120-4130 NN denotes biogenesis
T1919 4131-4134 CC denotes and
T1920 4135-4142 RB denotes further
T1921 4143-4150 VBP denotes support
T1922 4151-4154 DT denotes the
T1923 4155-4159 NN denotes idea
T1924 4160-4164 IN denotes that
T1926 4165-4170 EX denotes there
T1925 4171-4173 VBZ denotes is
T1927 4174-4175 DT denotes a
T1929 4176-4182 NN denotes muscle
T1930 4183-4188 NN denotes fiber
T1928 4189-4195 NN denotes switch
T1931 4195-4196 . denotes .
T1932 4196-4257 sentence denotes This conclusion was also confirmed by Western blot analysis.
T1933 4197-4201 DT denotes This
T1934 4202-4212 NN denotes conclusion
T1936 4213-4216 VBD denotes was
T1937 4217-4221 RB denotes also
T1935 4222-4231 VBN denotes confirmed
T1938 4232-4234 IN denotes by
T1939 4235-4242 NNP denotes Western
T1940 4243-4247 NN denotes blot
T1941 4248-4256 NN denotes analysis
T1942 4256-4257 . denotes .
T1943 4257-4394 sentence denotes As shown in Figure 3D, the characteristic type I fiber proteins, such as myoglobin and cytochrome c and b, were significantly increased.
T1944 4258-4260 IN denotes As
T1945 4261-4266 VBN denotes shown
T1947 4267-4269 IN denotes in
T1948 4270-4276 NN denotes Figure
T1949 4277-4279 CD denotes 3D
T1950 4279-4281 , denotes ,
T1951 4281-4284 DT denotes the
T1953 4285-4299 JJ denotes characteristic
T1954 4300-4304 NN denotes type
T1956 4305-4306 CD denotes I
T1955 4307-4312 NN denotes fiber
T1952 4313-4321 NN denotes proteins
T1957 4321-4323 , denotes ,
T1958 4323-4327 JJ denotes such
T1959 4328-4330 IN denotes as
T1960 4331-4340 NN denotes myoglobin
T1961 4341-4344 CC denotes and
T1962 4345-4355 NN denotes cytochrome
T1964 4356-4357 NN denotes c
T1965 4358-4361 CC denotes and
T1963 4362-4363 NN denotes b
T1966 4363-4365 , denotes ,
T1967 4365-4369 VBD denotes were
T1968 4370-4383 RB denotes significantly
T1946 4384-4393 VBN denotes increased
T1969 4393-4394 . denotes .
T1970 4394-4672 sentence denotes More importantly, the specialized contraction protein troponin I (slow) of type I fiber was robustly induced; this was accompanied by a marked reduction of the specialized contraction protein troponin I (fast) of type II fiber, indicating a high degree of fiber transformation.
T1971 4395-4399 RBR denotes More
T1972 4400-4411 RB denotes importantly
T1974 4411-4413 , denotes ,
T1975 4413-4416 DT denotes the
T1977 4417-4428 VBN denotes specialized
T1978 4429-4440 NN denotes contraction
T1976 4441-4448 NN denotes protein
T1979 4449-4457 NN denotes troponin
T1980 4458-4459 CD denotes I
T1981 4460-4461 -LRB- denotes (
T1982 4461-4465 JJ denotes slow
T1983 4465-4466 -RRB- denotes )
T1984 4467-4469 IN denotes of
T1985 4470-4474 NN denotes type
T1987 4475-4476 CD denotes I
T1986 4477-4482 NN denotes fiber
T1988 4483-4486 VBD denotes was
T1989 4487-4495 RB denotes robustly
T1973 4496-4503 VBN denotes induced
T1991 4503-4504 : denotes ;
T1992 4505-4509 DT denotes this
T1993 4510-4513 VBD denotes was
T1990 4514-4525 VBN denotes accompanied
T1994 4526-4528 IN denotes by
T1995 4529-4530 DT denotes a
T1997 4531-4537 JJ denotes marked
T1996 4538-4547 NN denotes reduction
T1998 4548-4550 IN denotes of
T1999 4551-4554 DT denotes the
T2001 4555-4566 VBN denotes specialized
T2002 4567-4578 NN denotes contraction
T2000 4579-4586 NN denotes protein
T2003 4587-4595 NN denotes troponin
T2004 4596-4597 CD denotes I
T2005 4598-4599 -LRB- denotes (
T2006 4599-4603 JJ denotes fast
T2007 4603-4604 -RRB- denotes )
T2008 4605-4607 IN denotes of
T2009 4608-4612 NN denotes type
T2011 4613-4615 CD denotes II
T2010 4616-4621 NN denotes fiber
T2012 4621-4623 , denotes ,
T2013 4623-4633 VBG denotes indicating
T2014 4634-4635 DT denotes a
T2016 4636-4640 JJ denotes high
T2015 4641-4647 NN denotes degree
T2017 4648-4650 IN denotes of
T2018 4651-4656 NN denotes fiber
T2019 4657-4671 NN denotes transformation
T2020 4671-4672 . denotes .
T2021 4672-4769 sentence denotes We next examined whether acute activation of endogenous PPARδ would induce similar target genes.
T2022 4673-4675 PRP denotes We
T2024 4676-4680 RB denotes next
T2023 4681-4689 VBD denotes examined
T2025 4690-4697 IN denotes whether
T2027 4698-4703 JJ denotes acute
T2028 4704-4714 NN denotes activation
T2029 4715-4717 IN denotes of
T2030 4718-4728 JJ denotes endogenous
T2031 4729-4734 NN denotes PPARδ
T2032 4735-4740 MD denotes would
T2026 4741-4747 VB denotes induce
T2033 4748-4755 JJ denotes similar
T2035 4756-4762 NN denotes target
T2034 4763-4768 NNS denotes genes
T2036 4768-4769 . denotes .
T2037 4769-5062 sentence denotes In agreement with the chronic effects in the transgenic mice, we found that, after treatment of wild-type C57B6J mice with the PPARδ-specific agonist GW501516 for only 10 d, genes for slow fiber contractile proteins, mitochondrial biogenesis, and β-oxidation were all upregulated (Figure 3E).
T2038 4770-4772 IN denotes In
T2040 4773-4782 NN denotes agreement
T2041 4783-4787 IN denotes with
T2042 4788-4791 DT denotes the
T2044 4792-4799 JJ denotes chronic
T2043 4800-4807 NNS denotes effects
T2045 4808-4810 IN denotes in
T2046 4811-4814 DT denotes the
T2048 4815-4825 JJ denotes transgenic
T2047 4826-4830 NNS denotes mice
T2049 4830-4832 , denotes ,
T2050 4832-4834 PRP denotes we
T2039 4835-4840 VBD denotes found
T2051 4841-4845 IN denotes that
T2053 4845-4847 , denotes ,
T2054 4847-4852 IN denotes after
T2055 4853-4862 NN denotes treatment
T2056 4863-4865 IN denotes of
T2057 4866-4870 JJ denotes wild
T2059 4870-4871 HYPH denotes -
T2058 4871-4875 NN denotes type
T2061 4876-4882 NN denotes C57B6J
T2060 4883-4887 NNS denotes mice
T2062 4888-4892 IN denotes with
T2063 4893-4896 DT denotes the
T2065 4897-4902 NN denotes PPARδ
T2067 4902-4903 HYPH denotes -
T2066 4903-4911 JJ denotes specific
T2068 4912-4919 NN denotes agonist
T2064 4920-4928 NN denotes GW501516
T2069 4929-4932 IN denotes for
T2070 4933-4937 RB denotes only
T2072 4938-4940 CD denotes 10
T2071 4941-4942 NNS denotes d
T2073 4942-4944 , denotes ,
T2074 4944-4949 NNS denotes genes
T2075 4950-4953 IN denotes for
T2076 4954-4958 JJ denotes slow
T2077 4959-4964 NN denotes fiber
T2079 4965-4976 JJ denotes contractile
T2078 4977-4985 NN denotes proteins
T2080 4985-4987 , denotes ,
T2081 4987-5000 JJ denotes mitochondrial
T2082 5001-5011 NN denotes biogenesis
T2083 5011-5013 , denotes ,
T2084 5013-5016 CC denotes and
T2085 5017-5018 NN denotes β
T2087 5018-5019 HYPH denotes -
T2086 5019-5028 NN denotes oxidation
T2088 5029-5033 VBD denotes were
T2089 5034-5037 RB denotes all
T2052 5038-5049 VBN denotes upregulated
T2090 5050-5051 -LRB- denotes (
T2091 5051-5057 NN denotes Figure
T2092 5058-5060 CD denotes 3E
T2093 5060-5061 -RRB- denotes )
T2094 5061-5062 . denotes .
T2095 5062-5229 sentence denotes This indicates that rapid, systematic, and coordinated changes of muscle fiber properties toward type I can be achieved by activation of the endogenous PPARδ pathway.
T2096 5063-5067 DT denotes This
T2097 5068-5077 VBZ denotes indicates
T2098 5078-5082 IN denotes that
T2100 5083-5088 JJ denotes rapid
T2102 5088-5090 , denotes ,
T2103 5090-5100 JJ denotes systematic
T2104 5100-5102 , denotes ,
T2105 5102-5105 CC denotes and
T2106 5106-5117 VBN denotes coordinated
T2101 5118-5125 NNS denotes changes
T2107 5126-5128 IN denotes of
T2108 5129-5135 NN denotes muscle
T2110 5136-5141 NN denotes fiber
T2109 5142-5152 NNS denotes properties
T2111 5153-5159 IN denotes toward
T2112 5160-5164 NN denotes type
T2113 5165-5166 CD denotes I
T2114 5167-5170 MD denotes can
T2115 5171-5173 VB denotes be
T2099 5174-5182 VBN denotes achieved
T2116 5183-5185 IN denotes by
T2117 5186-5196 NN denotes activation
T2118 5197-5199 IN denotes of
T2119 5200-5203 DT denotes the
T2121 5204-5214 JJ denotes endogenous
T2122 5215-5220 NN denotes PPARδ
T2120 5221-5228 NN denotes pathway
T2123 5228-5229 . denotes .
T4894 5240-5249 VBN denotes Increased
T4896 5250-5259 JJ denotes Oxidative
T4897 5260-5264 NN denotes Type
T4898 5265-5266 CD denotes I
T4895 5267-5273 NNS denotes Fibers
T4899 5274-5276 IN denotes in
T4900 5277-5280 DT denotes the
T4902 5281-5291 JJ denotes Transgenic
T4901 5292-5296 NNS denotes Mice
T4903 5296-5384 sentence denotes (A and B) Muscles in transgenic mice (TG) are redder than those in wild-type mice (WT).
T4904 5297-5298 -LRB- denotes (
T4905 5298-5299 LS denotes A
T4907 5300-5303 CC denotes and
T4908 5304-5305 LS denotes B
T4909 5305-5306 -RRB- denotes )
T4910 5307-5314 NNS denotes Muscles
T4911 5315-5317 IN denotes in
T4912 5318-5328 JJ denotes transgenic
T4913 5329-5333 NNS denotes mice
T4914 5334-5335 -LRB- denotes (
T4915 5335-5337 JJ denotes TG
T4916 5337-5338 -RRB- denotes )
T4906 5339-5342 VBP denotes are
T4917 5343-5349 JJR denotes redder
T4918 5350-5354 IN denotes than
T4919 5355-5360 DT denotes those
T4920 5361-5363 IN denotes in
T4921 5364-5368 JJ denotes wild
T4923 5368-5369 HYPH denotes -
T4922 5369-5373 NN denotes type
T4924 5374-5378 NNS denotes mice
T4925 5379-5380 -LRB- denotes (
T4926 5380-5382 NN denotes WT
T4927 5382-5383 -RRB- denotes )
T4928 5383-5384 . denotes .
T4929 5384-5444 sentence denotes (C) Metachromatic staining of the type II plantaris muscle.
T4930 5385-5386 -LRB- denotes (
T4931 5386-5387 LS denotes C
T4933 5387-5388 -RRB- denotes )
T4934 5389-5402 JJ denotes Metachromatic
T4932 5403-5411 NN denotes staining
T4935 5412-5414 IN denotes of
T4936 5415-5418 DT denotes the
T4938 5419-5423 NN denotes type
T4939 5424-5426 CD denotes II
T4940 5427-5436 NN denotes plantaris
T4937 5437-5443 NN denotes muscle
T4941 5443-5444 . denotes .
T4942 5444-5481 sentence denotes Type I fibers are stained dark blue.
T4943 5445-5449 NN denotes Type
T4945 5450-5451 CD denotes I
T4944 5452-5458 NNS denotes fibers
T4947 5459-5462 VBP denotes are
T4946 5463-5470 VBN denotes stained
T4948 5471-5475 RB denotes dark
T4949 5476-5480 JJ denotes blue
T4950 5480-5481 . denotes .
T5034 5492-5502 NN denotes Activation
T5036 5503-5505 IN denotes of
T5037 5506-5511 NN denotes PPARδ
T5035 5512-5519 VBZ denotes Induces
T5038 5520-5525 NNS denotes Genes
T5039 5526-5533 JJ denotes Typical
T5040 5534-5537 IN denotes for
T5041 5538-5542 NN denotes Type
T5043 5543-5544 CD denotes I
T5042 5545-5551 NNS denotes Fibers
T5044 5552-5555 CC denotes and
T5045 5556-5564 VBZ denotes Promotes
T5046 5565-5578 JJ denotes Mitochondrial
T5047 5579-5589 NN denotes Biogenesis
T5048 5589-5735 sentence denotes (A) Total RNA (10 μg/lane) prepared from gastrocnemius muscle of transgenic (TG) and wild-type (WT) littermates was probed with indicated probes.
T5049 5590-5591 -LRB- denotes (
T5050 5591-5592 LS denotes A
T5052 5592-5593 -RRB- denotes )
T5053 5594-5599 JJ denotes Total
T5054 5600-5603 NN denotes RNA
T5055 5604-5605 -LRB- denotes (
T5057 5605-5607 CD denotes 10
T5056 5608-5610 NNS denotes μg
T5058 5610-5611 SYM denotes /
T5059 5611-5615 NN denotes lane
T5060 5615-5616 -RRB- denotes )
T5061 5617-5625 VBN denotes prepared
T5062 5626-5630 IN denotes from
T5063 5631-5644 NN denotes gastrocnemius
T5064 5645-5651 NN denotes muscle
T5065 5652-5654 IN denotes of
T5066 5655-5665 JJ denotes transgenic
T5068 5666-5667 -LRB- denotes (
T5069 5667-5669 JJ denotes TG
T5070 5669-5670 -RRB- denotes )
T5071 5671-5674 CC denotes and
T5072 5675-5679 JJ denotes wild
T5074 5679-5680 HYPH denotes -
T5073 5680-5684 NN denotes type
T5075 5685-5686 -LRB- denotes (
T5076 5686-5688 NN denotes WT
T5077 5688-5689 -RRB- denotes )
T5067 5690-5701 NNS denotes littermates
T5078 5702-5705 VBD denotes was
T5051 5706-5712 VBN denotes probed
T5079 5713-5717 IN denotes with
T5080 5718-5727 VBN denotes indicated
T5081 5728-5734 NNS denotes probes
T5082 5734-5735 . denotes .
T5083 5735-5789 sentence denotes The fold increase of induction of each gene is shown.
T5084 5736-5739 DT denotes The
T5086 5740-5744 JJ denotes fold
T5085 5745-5753 NN denotes increase
T5088 5754-5756 IN denotes of
T5089 5757-5766 NN denotes induction
T5090 5767-5769 IN denotes of
T5091 5770-5774 DT denotes each
T5092 5775-5779 NN denotes gene
T5093 5780-5782 VBZ denotes is
T5087 5783-5788 VBN denotes shown
T5094 5788-5789 . denotes .
T5095 5789-6006 sentence denotes (B) Total genomic DNA (10 μg/lane) prepared from gastrocnemius muscle was digested with Nco1 and subjected to Southern analysis with COXII (mitochondrial genome–encoded) and MCIP1 (nuclear genome–encoded) DNA probes.
T5096 5790-5791 -LRB- denotes (
T5097 5791-5792 LS denotes B
T5099 5792-5793 -RRB- denotes )
T5100 5794-5799 JJ denotes Total
T5102 5800-5807 JJ denotes genomic
T5101 5808-5811 NN denotes DNA
T5103 5812-5813 -LRB- denotes (
T5105 5813-5815 CD denotes 10
T5104 5816-5818 NNS denotes μg
T5106 5818-5819 SYM denotes /
T5107 5819-5823 NN denotes lane
T5108 5823-5824 -RRB- denotes )
T5109 5825-5833 VBN denotes prepared
T5110 5834-5838 IN denotes from
T5111 5839-5852 NN denotes gastrocnemius
T5112 5853-5859 NN denotes muscle
T5113 5860-5863 VBD denotes was
T5098 5864-5872 VBN denotes digested
T5114 5873-5877 IN denotes with
T5115 5878-5882 NN denotes Nco1
T5116 5883-5886 CC denotes and
T5117 5887-5896 VBN denotes subjected
T5118 5897-5899 IN denotes to
T5119 5900-5908 NNP denotes Southern
T5120 5909-5917 NN denotes analysis
T5121 5918-5922 IN denotes with
T5122 5923-5928 NN denotes COXII
T5124 5929-5930 -LRB- denotes (
T5126 5930-5943 JJ denotes mitochondrial
T5127 5944-5950 NN denotes genome
T5128 5950-5951 HYPH denotes –
T5125 5951-5958 VBN denotes encoded
T5129 5958-5959 -RRB- denotes )
T5130 5960-5963 CC denotes and
T5131 5964-5969 NN denotes MCIP1
T5132 5970-5971 -LRB- denotes (
T5134 5971-5978 JJ denotes nuclear
T5135 5979-5985 NN denotes genome
T5136 5985-5986 HYPH denotes –
T5133 5986-5993 VBN denotes encoded
T5137 5993-5994 -RRB- denotes )
T5138 5995-5998 NN denotes DNA
T5123 5999-6005 NNS denotes probes
T5139 6005-6006 . denotes .
T5140 6006-6114 sentence denotes (C) Equal amounts of gastrocnemius muscle were collected from both transgenic mice and control littermates.
T5141 6007-6008 -LRB- denotes (
T5142 6008-6009 LS denotes C
T5144 6009-6010 -RRB- denotes )
T5145 6011-6016 JJ denotes Equal
T5146 6017-6024 NNS denotes amounts
T5147 6025-6027 IN denotes of
T5148 6028-6041 NN denotes gastrocnemius
T5149 6042-6048 NN denotes muscle
T5150 6049-6053 VBD denotes were
T5143 6054-6063 VBN denotes collected
T5151 6064-6068 IN denotes from
T5152 6069-6073 CC denotes both
T5154 6074-6084 JJ denotes transgenic
T5153 6085-6089 NNS denotes mice
T5155 6090-6093 CC denotes and
T5156 6094-6101 NN denotes control
T5157 6102-6113 NNS denotes littermates
T5158 6113-6114 . denotes .
T5159 6114-6184 sentence denotes Total mitochondrial DNA was isolated and separated on 1% agarose gel.
T5160 6115-6120 JJ denotes Total
T5162 6121-6134 JJ denotes mitochondrial
T5161 6135-6138 NN denotes DNA
T5164 6139-6142 VBD denotes was
T5163 6143-6151 VBN denotes isolated
T5165 6152-6155 CC denotes and
T5166 6156-6165 VBN denotes separated
T5167 6166-6168 IN denotes on
T5168 6169-6170 CD denotes 1
T5169 6170-6171 NN denotes %
T5171 6172-6179 NN denotes agarose
T5170 6180-6183 NN denotes gel
T5172 6183-6184 . denotes .
T5173 6184-6275 sentence denotes The relative abundance of mitochondrial DNA in transgenic and wild-type mice is presented.
T5174 6185-6188 DT denotes The
T5176 6189-6197 JJ denotes relative
T5175 6198-6207 NN denotes abundance
T5178 6208-6210 IN denotes of
T5179 6211-6224 JJ denotes mitochondrial
T5180 6225-6228 NN denotes DNA
T5181 6229-6231 IN denotes in
T5182 6232-6242 JJ denotes transgenic
T5184 6243-6246 CC denotes and
T5185 6247-6251 JJ denotes wild
T5187 6251-6252 HYPH denotes -
T5186 6252-6256 NN denotes type
T5183 6257-6261 NNS denotes mice
T5188 6262-6264 VBZ denotes is
T5177 6265-6274 VBN denotes presented
T5189 6274-6275 . denotes .
T5190 6275-6355 sentence denotes (D) Western blot analysis of muscle fiber markers and mitochondrial components.
T5191 6276-6277 -LRB- denotes (
T5192 6277-6278 LS denotes D
T5194 6278-6279 -RRB- denotes )
T5195 6280-6287 NNP denotes Western
T5196 6288-6292 NN denotes blot
T5193 6293-6301 NN denotes analysis
T5197 6302-6304 IN denotes of
T5198 6305-6311 NN denotes muscle
T5199 6312-6317 NN denotes fiber
T5200 6318-6325 NNS denotes markers
T5201 6326-6329 CC denotes and
T5202 6330-6343 JJ denotes mitochondrial
T5203 6344-6354 NNS denotes components
T5204 6354-6355 . denotes .
T5205 6355-6427 sentence denotes Each lane was loaded with 80 μg of total gastrocnemius muscle extracts.
T5206 6356-6360 DT denotes Each
T5207 6361-6365 NN denotes lane
T5209 6366-6369 VBD denotes was
T5208 6370-6376 VBN denotes loaded
T5210 6377-6381 IN denotes with
T5211 6382-6384 CD denotes 80
T5212 6385-6387 NNS denotes μg
T5213 6388-6390 IN denotes of
T5214 6391-6396 JJ denotes total
T5216 6397-6410 NN denotes gastrocnemius
T5217 6411-6417 NN denotes muscle
T5215 6418-6426 NNS denotes extracts
T5218 6426-6427 . denotes .
T5219 6427-6514 sentence denotes (E) Wild-type C57B6 mice were treated with vehicle or PPARδ agonist GW501516 for 10 d.
T5220 6428-6429 -LRB- denotes (
T5221 6429-6430 LS denotes E
T5223 6430-6431 -RRB- denotes )
T5224 6432-6436 JJ denotes Wild
T5226 6436-6437 HYPH denotes -
T5225 6437-6441 NN denotes type
T5228 6442-6447 NN denotes C57B6
T5227 6448-6452 NNS denotes mice
T5229 6453-6457 VBD denotes were
T5222 6458-6465 VBN denotes treated
T5230 6466-6470 IN denotes with
T5231 6471-6478 NN denotes vehicle
T5232 6479-6481 CC denotes or
T5233 6482-6487 NN denotes PPARδ
T5234 6488-6495 NN denotes agonist
T5235 6496-6504 NN denotes GW501516
T5236 6505-6508 IN denotes for
T5237 6509-6511 CD denotes 10
T5238 6512-6513 NN denotes d
T5239 6513-6514 . denotes .
T5240 6514-6610 sentence denotes Total RNA (10 μg/lane) prepared from the gastrocnemius muscle was probed with indicated probes.
T5241 6515-6520 JJ denotes Total
T5242 6521-6524 NN denotes RNA
T5244 6525-6526 -LRB- denotes (
T5246 6526-6528 CD denotes 10
T5245 6529-6531 NNS denotes μg
T5247 6531-6532 SYM denotes /
T5248 6532-6536 NN denotes lane
T5249 6536-6537 -RRB- denotes )
T5250 6538-6546 VBN denotes prepared
T5251 6547-6551 IN denotes from
T5252 6552-6555 DT denotes the
T5254 6556-6569 NN denotes gastrocnemius
T5253 6570-6576 NN denotes muscle
T5255 6577-6580 VBD denotes was
T5243 6581-6587 VBN denotes probed
T5256 6588-6592 IN denotes with
T5257 6593-6602 VBN denotes indicated
T5258 6603-6609 NNS denotes probes
T5259 6609-6610 . denotes .
R1000 T1571 T1548 prep in,produced
R1001 T1572 T1573 amod wild,type
R1002 T1573 T1575 compound type,littermates
R1003 T1574 T1573 punct -,type
R1004 T1575 T1571 pobj littermates,in
R1005 T1576 T1548 punct .,produced
R1006 T1578 T1579 advmod Interestingly,was
R1007 T1580 T1579 punct ", ",was
R1008 T1581 T1582 det the,level
R1009 T1582 T1579 nsubj level,was
R1010 T1583 T1582 prep of,level
R1011 T1584 T1585 amod endogenous,protein
R1012 T1585 T1583 pobj protein,of
R1013 T1586 T1585 compound muscle,protein
R1014 T1587 T1585 compound PPARδ,protein
R1015 T1588 T1582 prep in,level
R1016 T1589 T1590 det the,mice
R1017 T1590 T1588 pobj mice,in
R1018 T1591 T1590 amod transgenic,mice
R1019 T1592 T1593 advmod much,higher
R1020 T1593 T1579 acomp higher,was
R1021 T1594 T1593 prep than,higher
R1022 T1595 T1594 prep in,than
R1023 T1596 T1597 det the,littermates
R1024 T1597 T1595 pobj littermates,in
R1025 T1598 T1597 compound control,littermates
R1026 T1599 T1579 punct .,was
R1027 T1601 T1602 det The,increase
R1028 T1602 T1604 nsubjpass increase,caused
R1029 T1603 T1602 amod substantial,increase
R1030 T1605 T1602 prep of,increase
R1031 T1606 T1607 amod endogenous,PPARδ
R1032 T1607 T1605 pobj PPARδ,of
R1033 T1608 T1604 aux may,caused
R1034 T1609 T1604 aux have,caused
R1035 T1610 T1604 auxpass been,caused
R1036 T1611 T1604 agent by,caused
R1037 T1612 T1613 det a,switch
R1038 T1613 T1611 pobj switch,by
R1039 T1614 T1613 prep to,switch
R1040 T1615 T1616 nmod type,fiber
R1041 T1616 T1614 pobj fiber,to
R1042 T1617 T1615 nummod I,type
R1043 T1618 T1619 punct (,see
R1044 T1619 T1616 parataxis see,fiber
R1045 T1620 T1619 advmod below,see
R1046 T1621 T1619 punct ),see
R1047 T1622 T1616 punct ", ",fiber
R1048 T1623 T1624 dep which,expresses
R1049 T1624 T1616 relcl expresses,fiber
R1050 T1625 T1624 advmod intrinsically,expresses
R1051 T1626 T1627 amod higher,levels
R1052 T1627 T1624 dobj levels,expresses
R1053 T1628 T1627 prep of,levels
R1054 T1629 T1628 pobj PPARδ,of
R1055 T1630 T1631 punct (,1A
R1056 T1631 T1624 parataxis 1A,expresses
R1057 T1632 T1631 nmod Figure,1A
R1058 T1633 T1631 cc and,1A
R1059 T1634 T1631 conj 1B,1A
R1060 T1635 T1631 punct ),1A
R1061 T1636 T1604 punct .,caused
R1062 T1638 T1639 nmod Type,muscle
R1063 T1639 T1641 nsubjpass muscle,distinguished
R1064 T1640 T1638 nummod I,Type
R1065 T1642 T1641 aux can,distinguished
R1066 T1643 T1641 auxpass be,distinguished
R1067 T1644 T1641 advmod readily,distinguished
R1068 T1645 T1641 prep from,distinguished
R1069 T1646 T1647 nmod type,muscle
R1070 T1647 T1645 pobj muscle,from
R1071 T1648 T1646 nummod II,type
R1072 T1649 T1646 cc or,type
R1073 T1650 T1646 conj mixed,type
R1074 T1651 T1641 prep by,distinguished
R1075 T1652 T1653 poss its,color
R1076 T1653 T1651 pobj color,by
R1077 T1654 T1653 amod red,color
R1078 T1655 T1641 punct ", ",distinguished
R1079 T1656 T1641 prep because,distinguished
R1080 T1657 T1656 prep of,because
R1081 T1658 T1659 poss its,concentration
R1082 T1659 T1657 pobj concentration,of
R1083 T1660 T1659 amod high,concentration
R1084 T1661 T1659 prep of,concentration
R1085 T1662 T1661 pobj myoglobin,of
R1086 T1663 T1662 punct ", ",myoglobin
R1087 T1664 T1665 det a,protein
R1088 T1665 T1662 appos protein,myoglobin
R1089 T1666 T1667 advmod typically,expressed
R1090 T1667 T1665 acl expressed,protein
R1091 T1668 T1667 prep in,expressed
R1092 T1669 T1670 amod oxidative,fibers
R1093 T1670 T1668 pobj fibers,in
R1094 T1671 T1670 compound muscle,fibers
R1095 T1672 T1641 punct .,distinguished
R1096 T1674 T1675 nsubj We,found
R1097 T1676 T1677 mark that,appeared
R1098 T1677 T1675 ccomp appeared,found
R1099 T1678 T1677 nsubj muscles,appeared
R1100 T1679 T1678 prep in,muscles
R1101 T1680 T1681 det the,mice
R1102 T1681 T1679 pobj mice,in
R1103 T1682 T1681 amod transgenic,mice
R1104 T1683 T1677 oprd redder,appeared
R1105 T1684 T1685 punct (,Figure
R1106 T1685 T1677 parataxis Figure,appeared
R1107 T1686 T1685 nummod 2A,Figure
R1108 T1687 T1685 punct ),Figure
R1109 T1688 T1677 punct ", ",appeared
R1110 T1689 T1690 dep which,is
R1111 T1690 T1677 advcl is,appeared
R1112 T1691 T1692 advmod particularly,evident
R1113 T1692 T1690 acomp evident,is
R1114 T1693 T1690 prep in,is
R1115 T1694 T1695 det the,fibers
R1116 T1695 T1693 pobj fibers,in
R1117 T1696 T1697 amod mixed,II
R1118 T1697 T1695 nummod II,fibers
R1119 T1698 T1697 nmod type,II
R1120 T1699 T1697 nummod I,II
R1121 T1700 T1697 punct /,II
R1122 T1701 T1695 prep of,fibers
R1123 T1702 T1703 det the,hindlimb
R1124 T1703 T1701 pobj hindlimb,of
R1125 T1704 T1705 punct (,Figure
R1126 T1705 T1690 parataxis Figure,is
R1127 T1706 T1705 nummod 2B,Figure
R1128 T1707 T1705 punct ),Figure
R1129 T1708 T1675 punct .,found
R1130 T1710 T1711 advmod Indeed,revealed
R1131 T1712 T1711 punct ", ",revealed
R1132 T1713 T1714 amod metachromatic,staining
R1133 T1714 T1711 nsubj staining,revealed
R1134 T1715 T1716 det a,transformation
R1135 T1716 T1711 dobj transformation,revealed
R1136 T1717 T1716 amod substantial,transformation
R1137 T1718 T1719 compound muscle,fiber
R1138 T1719 T1716 compound fiber,transformation
R1139 T1720 T1721 punct (,Figure
R1140 T1721 T1711 parataxis Figure,revealed
R1141 T1722 T1721 nummod 2C,Figure
R1142 T1723 T1721 punct ),Figure
R1143 T1724 T1711 punct .,revealed
R1144 T1726 T1727 prep In,estimated
R1145 T1728 T1729 compound gastrocnemius,muscle
R1146 T1729 T1726 pobj muscle,In
R1147 T1730 T1727 punct ", ",estimated
R1148 T1731 T1727 nsubj we,estimated
R1149 T1732 T1733 mark that,was
R1150 T1733 T1727 ccomp was,estimated
R1151 T1734 T1733 expl there,was
R1152 T1735 T1736 det a,increase
R1153 T1736 T1733 attr increase,was
R1154 T1737 T1736 amod 2-fold,increase
R1155 T1738 T1736 prep of,increase
R1156 T1739 T1740 nmod type,fibers
R1157 T1740 T1738 pobj fibers,of
R1158 T1741 T1739 nummod I,type
R1159 T1742 T1727 punct .,estimated
R1160 T1744 T1745 det A,component
R1161 T1745 T1747 nsubj component,is
R1162 T1746 T1745 amod diagnostic,component
R1163 T1748 T1745 prep of,component
R1164 T1749 T1750 amod oxidative,fibers
R1165 T1750 T1748 pobj fibers,of
R1166 T1751 T1752 poss their,content
R1167 T1752 T1747 attr content,is
R1168 T1753 T1752 amod high,content
R1169 T1754 T1752 nmod myoglobin,content
R1170 T1755 T1754 cc and,myoglobin
R1171 T1756 T1754 conj mitochondrial,myoglobin
R1172 T1757 T1752 punct ", ",content
R1173 T1758 T1759 dep which,supported
R1174 T1759 T1752 relcl supported,content
R1175 T1760 T1759 auxpass is,supported
R1176 T1761 T1759 agent by,supported
R1177 T1762 T1763 det the,analysis
R1178 T1763 T1761 pobj analysis,by
R1179 T1764 T1763 compound mRNA,analysis
R1180 T1765 T1763 acl shown,analysis
R1181 T1766 T1765 prep in,shown
R1182 T1767 T1766 pobj Figure,in
R1183 T1768 T1767 nummod 3A,Figure
R1184 T1769 T1747 punct .,is
R1185 T1771 T1772 prep In,elevated
R1186 T1773 T1771 pobj addition,In
R1187 T1774 T1773 prep to,addition
R1188 T1775 T1774 pobj myoglobin,to
R1189 T1776 T1772 punct ", ",elevated
R1190 T1777 T1778 amod mitochondrial,components
R1191 T1778 T1772 nsubjpass components,elevated
R1192 T1779 T1778 prep for,components
R1193 T1780 T1781 compound electron,transfer
R1194 T1781 T1779 pobj transfer,for
R1195 T1782 T1783 punct (,c
R1196 T1783 T1778 parataxis c,components
R1197 T1784 T1783 compound cytochrome,c
R1198 T1785 T1783 cc and,c
R1199 T1786 T1787 compound cytochrome,c
R1200 T1787 T1788 compound c,oxidase
R1201 T1788 T1783 conj oxidase,c
R1202 T1789 T1790 punct [,COX
R1203 T1790 T1788 parataxis COX,oxidase
R1204 T1791 T1790 punct ],COX
R1205 T1792 T1783 appos II,c
R1206 T1793 T1792 cc and,II
R1207 T1794 T1792 conj IV,II
R1208 T1795 T1783 punct ),c
R1209 T1796 T1778 cc and,components
R1210 T1797 T1798 amod fatty,acid
R1211 T1798 T1800 compound acid,enzymes
R1212 T1799 T1798 punct -,acid
R1213 T1800 T1778 conj enzymes,components
R1214 T1801 T1802 compound β,oxidation
R1215 T1802 T1800 compound oxidation,enzymes
R1216 T1803 T1802 punct -,oxidation
R1217 T1804 T1772 auxpass were,elevated
R1218 T1805 T1806 punct (,data
R1219 T1806 T1772 parataxis data,elevated
R1220 T1807 T1806 dep Figure,data
R1221 T1808 T1807 nummod 3A,Figure
R1222 T1809 T1806 punct ;,data
R1223 T1810 T1806 amod unpublished,data
R1224 T1811 T1806 punct ),data
R1225 T1812 T1772 punct .,elevated
R1226 T1814 T1815 det These,effects
R1227 T1815 T1816 nsubj effects,appear
R1228 T1817 T1818 aux to,be
R1229 T1818 T1816 xcomp be,appear
R1230 T1819 T1820 amod direct,consequences
R1231 T1820 T1818 attr consequences,be
R1232 T1821 T1820 prep of,consequences
R1233 T1822 T1823 compound PPARδ,activation
R1234 T1823 T1821 pobj activation,of
R1235 T1824 T1818 punct ", ",be
R1236 T1825 T1826 mark as,remained
R1237 T1826 T1818 advcl remained,be
R1238 T1827 T1826 nsubj levels,remained
R1239 T1828 T1827 prep of,levels
R1240 T1829 T1828 pobj PGC,of
R1241 T1830 T1829 punct -,PGC
R1242 T1831 T1829 nummod 1α,PGC
R1243 T1832 T1829 punct ", ",PGC
R1244 T1833 T1834 det a,coactivator
R1245 T1834 T1829 appos coactivator,PGC
R1246 T1835 T1834 acl involved,coactivator
R1247 T1836 T1835 prep in,involved
R1248 T1837 T1838 compound muscle,fiber
R1249 T1838 T1839 compound fiber,switch
R1250 T1839 T1836 pobj switch,in
R1251 T1840 T1839 cc and,switch
R1252 T1841 T1842 amod mitochondrial,biogenesis
R1253 T1842 T1839 conj biogenesis,switch
R1254 T1843 T1844 punct (,Wu
R1255 T1844 T1835 meta Wu,involved
R1256 T1845 T1844 nmod et,Wu
R1257 T1846 T1844 nmod al.,Wu
R1258 T1847 T1844 nummod 1999,Wu
R1259 T1848 T1844 punct ;,Wu
R1260 T1849 T1844 nmod Lehman,Wu
R1261 T1850 T1844 nmod et,Wu
R1262 T1851 T1844 nmod al.,Wu
R1263 T1852 T1844 nummod 2000,Wu
R1264 T1853 T1844 punct ;,Wu
R1265 T1854 T1844 nmod Lin,Wu
R1266 T1855 T1844 nmod et,Wu
R1267 T1856 T1844 nmod al.,Wu
R1268 T1857 T1844 nummod 2002,Wu
R1269 T1858 T1844 punct ),Wu
R1270 T1859 T1826 punct ", ",remained
R1271 T1860 T1826 oprd unchanged,remained
R1272 T1861 T1816 punct .,appear
R1273 T1863 T1864 compound Southern,blot
R1274 T1864 T1865 compound blot,analysis
R1275 T1865 T1866 nsubj analysis,detected
R1276 T1867 T1868 det a,number
R1277 T1868 T1866 dobj number,detected
R1278 T1869 T1870 advmod substantially,higher
R1279 T1870 T1868 amod higher,number
R1280 T1871 T1868 compound copy,number
R1281 T1872 T1868 prep of,number
R1282 T1873 T1874 det the,DNA
R1283 T1874 T1872 pobj DNA,of
R1284 T1875 T1874 amod mitochondrial,DNA
R1285 T1876 T1877 npadvmod genome,encoded
R1286 T1877 T1874 amod encoded,DNA
R1287 T1878 T1877 punct –,encoded
R1288 T1879 T1874 compound COXII,DNA
R1289 T1880 T1866 prep in,detected
R1290 T1881 T1882 det the,mice
R1291 T1882 T1880 pobj mice,in
R1292 T1883 T1882 amod transgenic,mice
R1293 T1884 T1885 punct (,Figure
R1294 T1885 T1866 parataxis Figure,detected
R1295 T1886 T1885 nummod 3B,Figure
R1296 T1887 T1885 punct ),Figure
R1297 T1888 T1866 punct .,detected
R1298 T1890 T1891 amod Mitochondrial,DNA
R1299 T1891 T1892 nsubjpass DNA,increased
R1300 T1893 T1892 auxpass was,increased
R1301 T1894 T1892 advmod 2.3,increased
R1302 T1895 T1894 punct -,2.3
R1303 T1896 T1894 advmod fold,2.3
R1304 T1897 T1892 prep in,increased
R1305 T1898 T1899 compound gastrocnemius,muscle
R1306 T1899 T1897 pobj muscle,in
R1307 T1900 T1899 prep of,muscle
R1308 T1901 T1902 det the,mice
R1309 T1902 T1900 pobj mice,of
R1310 T1903 T1902 amod transgenic,mice
R1311 T1904 T1905 punct (,Figure
R1312 T1905 T1892 parataxis Figure,increased
R1313 T1906 T1905 nummod 3C,Figure
R1314 T1907 T1905 punct ),Figure
R1315 T1908 T1892 punct .,increased
R1316 T1910 T1911 det These,results
R1317 T1911 T1912 nsubj results,reveal
R1318 T1913 T1914 det a,stimulation
R1319 T1914 T1912 dobj stimulation,reveal
R1320 T1915 T1914 amod marked,stimulation
R1321 T1916 T1914 prep of,stimulation
R1322 T1917 T1918 amod mitochondrial,biogenesis
R1323 T1918 T1916 pobj biogenesis,of
R1324 T1919 T1912 cc and,reveal
R1325 T1920 T1921 advmod further,support
R1326 T1921 T1912 conj support,reveal
R1327 T1922 T1923 det the,idea
R1328 T1923 T1921 dobj idea,support
R1329 T1924 T1925 mark that,is
R1330 T1925 T1923 acl is,idea
R1331 T1926 T1925 expl there,is
R1332 T1927 T1928 det a,switch
R1333 T1928 T1925 attr switch,is
R1334 T1929 T1930 compound muscle,fiber
R1335 T1930 T1928 compound fiber,switch
R1336 T1931 T1912 punct .,reveal
R1337 T1933 T1934 det This,conclusion
R1338 T1934 T1935 nsubjpass conclusion,confirmed
R1339 T1936 T1935 auxpass was,confirmed
R1340 T1937 T1935 advmod also,confirmed
R1341 T1938 T1935 prep by,confirmed
R1342 T1939 T1940 compound Western,blot
R1343 T1940 T1941 compound blot,analysis
R1344 T1941 T1938 pobj analysis,by
R1345 T1942 T1935 punct .,confirmed
R1346 T1944 T1945 mark As,shown
R1347 T1945 T1946 advcl shown,increased
R1348 T1947 T1945 prep in,shown
R1349 T1948 T1947 pobj Figure,in
R1350 T1949 T1948 nummod 3D,Figure
R1351 T1950 T1946 punct ", ",increased
R1352 T1951 T1952 det the,proteins
R1353 T1952 T1946 nsubjpass proteins,increased
R1354 T1953 T1952 amod characteristic,proteins
R1355 T1954 T1955 nmod type,fiber
R1356 T1955 T1952 compound fiber,proteins
R1357 T1956 T1954 nummod I,type
R1358 T1957 T1952 punct ", ",proteins
R1359 T1958 T1959 amod such,as
R1360 T1959 T1952 prep as,proteins
R1361 T1960 T1959 pobj myoglobin,as
R1362 T1961 T1960 cc and,myoglobin
R1363 T1962 T1963 nmod cytochrome,b
R1364 T1963 T1960 conj b,myoglobin
R1365 T1964 T1963 nmod c,b
R1366 T1965 T1964 cc and,c
R1367 T1966 T1946 punct ", ",increased
R1368 T1967 T1946 auxpass were,increased
R1369 T1968 T1946 advmod significantly,increased
R1370 T1969 T1946 punct .,increased
R1371 T1971 T1972 advmod More,importantly
R1372 T1972 T1973 advmod importantly,induced
R1373 T1973 T1990 ccomp induced,accompanied
R1374 T1974 T1973 punct ", ",induced
R1375 T1975 T1976 det the,protein
R1376 T1976 T1973 nsubjpass protein,induced
R1377 T1977 T1976 amod specialized,protein
R1378 T1978 T1976 compound contraction,protein
R1379 T1979 T1976 appos troponin,protein
R1380 T1980 T1979 nummod I,troponin
R1381 T1981 T1982 punct (,slow
R1382 T1982 T1976 parataxis slow,protein
R1383 T1983 T1982 punct ),slow
R1384 T1984 T1976 prep of,protein
R1385 T1985 T1986 nmod type,fiber
R1386 T1986 T1984 pobj fiber,of
R1387 T1987 T1985 nummod I,type
R1388 T1988 T1973 auxpass was,induced
R1389 T1989 T1973 advmod robustly,induced
R1390 T1991 T1990 punct ;,accompanied
R1391 T1992 T1990 nsubjpass this,accompanied
R1392 T1993 T1990 auxpass was,accompanied
R1393 T1994 T1990 agent by,accompanied
R1394 T1995 T1996 det a,reduction
R1395 T1996 T1994 pobj reduction,by
R1396 T1997 T1996 amod marked,reduction
R1397 T1998 T1996 prep of,reduction
R1398 T1999 T2000 det the,protein
R1399 T2000 T1998 pobj protein,of
R1400 T2001 T2000 amod specialized,protein
R1401 T2002 T2000 compound contraction,protein
R1402 T2003 T2000 appos troponin,protein
R1403 T2004 T2003 nummod I,troponin
R1404 T2005 T2006 punct (,fast
R1405 T2006 T2003 parataxis fast,troponin
R1406 T2007 T2006 punct ),fast
R1407 T2008 T2000 prep of,protein
R1408 T2009 T2010 nmod type,fiber
R1409 T2010 T2008 pobj fiber,of
R1410 T2011 T2009 nummod II,type
R1411 T2012 T1990 punct ", ",accompanied
R1412 T2013 T1990 advcl indicating,accompanied
R1413 T2014 T2015 det a,degree
R1414 T2015 T2013 dobj degree,indicating
R1415 T2016 T2015 amod high,degree
R1416 T2017 T2015 prep of,degree
R1417 T2018 T2019 compound fiber,transformation
R1418 T2019 T2017 pobj transformation,of
R1419 T2020 T1990 punct .,accompanied
R1420 T2022 T2023 nsubj We,examined
R1421 T2024 T2023 advmod next,examined
R1422 T2025 T2026 mark whether,induce
R1423 T2026 T2023 ccomp induce,examined
R1424 T2027 T2028 amod acute,activation
R1425 T2028 T2026 nsubj activation,induce
R1426 T2029 T2028 prep of,activation
R1427 T2030 T2031 amod endogenous,PPARδ
R1428 T2031 T2029 pobj PPARδ,of
R1429 T2032 T2026 aux would,induce
R1430 T2033 T2034 amod similar,genes
R1431 T2034 T2026 dobj genes,induce
R1432 T2035 T2034 compound target,genes
R1433 T2036 T2023 punct .,examined
R1434 T2038 T2039 prep In,found
R1435 T2040 T2038 pobj agreement,In
R1436 T2041 T2040 prep with,agreement
R1437 T2042 T2043 det the,effects
R1438 T2043 T2041 pobj effects,with
R1439 T2044 T2043 amod chronic,effects
R1440 T2045 T2043 prep in,effects
R1441 T2046 T2047 det the,mice
R1442 T2047 T2045 pobj mice,in
R1443 T2048 T2047 amod transgenic,mice
R1444 T2049 T2039 punct ", ",found
R1445 T2050 T2039 nsubj we,found
R1446 T2051 T2052 mark that,upregulated
R1447 T2052 T2039 ccomp upregulated,found
R1448 T2053 T2052 punct ", ",upregulated
R1449 T2054 T2052 prep after,upregulated
R1450 T2055 T2054 pobj treatment,after
R1451 T2056 T2055 prep of,treatment
R1452 T2057 T2058 amod wild,type
R1453 T2058 T2060 compound type,mice
R1454 T2059 T2058 punct -,type
R1455 T2060 T2056 pobj mice,of
R1456 T2061 T2060 compound C57B6J,mice
R1457 T2062 T2055 prep with,treatment
R1458 T2063 T2064 det the,GW501516
R1459 T2064 T2062 pobj GW501516,with
R1460 T2065 T2066 npadvmod PPARδ,specific
R1461 T2066 T2064 amod specific,GW501516
R1462 T2067 T2066 punct -,specific
R1463 T2068 T2064 compound agonist,GW501516
R1464 T2069 T2055 prep for,treatment
R1465 T2070 T2071 advmod only,d
R1466 T2071 T2069 pobj d,for
R1467 T2072 T2071 nummod 10,d
R1468 T2073 T2052 punct ", ",upregulated
R1469 T2074 T2052 nsubjpass genes,upregulated
R1470 T2075 T2074 prep for,genes
R1471 T2076 T2077 amod slow,fiber
R1472 T2077 T2078 nmod fiber,proteins
R1473 T2078 T2075 pobj proteins,for
R1474 T2079 T2078 amod contractile,proteins
R1475 T2080 T2078 punct ", ",proteins
R1476 T2081 T2082 amod mitochondrial,biogenesis
R1477 T2082 T2078 conj biogenesis,proteins
R1478 T2083 T2082 punct ", ",biogenesis
R1479 T2084 T2082 cc and,biogenesis
R1480 T2085 T2086 compound β,oxidation
R1481 T2086 T2082 conj oxidation,biogenesis
R1482 T2087 T2086 punct -,oxidation
R1483 T2088 T2052 auxpass were,upregulated
R1484 T2089 T2052 advmod all,upregulated
R1485 T2090 T2091 punct (,Figure
R1486 T2092 T2091 nummod 3E,Figure
R1487 T2091 T2052 parataxis Figure,upregulated
R1488 T2093 T2091 punct ),Figure
R1489 T2094 T2039 punct .,found
R1490 T2096 T2097 nsubj This,indicates
R1491 T2098 T2099 mark that,achieved
R1492 T2099 T2097 ccomp achieved,indicates
R1493 T2100 T2101 amod rapid,changes
R1494 T2101 T2099 nsubjpass changes,achieved
R1495 T2102 T2100 punct ", ",rapid
R1496 T2103 T2100 conj systematic,rapid
R1497 T2104 T2103 punct ", ",systematic
R1498 T2105 T2103 cc and,systematic
R1499 T2106 T2103 conj coordinated,systematic
R1500 T2107 T2101 prep of,changes
R1501 T2108 T2109 compound muscle,properties
R1502 T2109 T2107 pobj properties,of
R1503 T2110 T2109 compound fiber,properties
R1504 T2111 T2101 prep toward,changes
R1505 T2112 T2111 pobj type,toward
R1506 T2113 T2112 nummod I,type
R1507 T2114 T2099 aux can,achieved
R1508 T2115 T2099 auxpass be,achieved
R1509 T2116 T2099 prep by,achieved
R1510 T2117 T2116 pobj activation,by
R1511 T2118 T2117 prep of,activation
R1512 T2119 T2120 det the,pathway
R1513 T2120 T2118 pobj pathway,of
R1514 T2121 T2120 amod endogenous,pathway
R1515 T2122 T2120 compound PPARδ,pathway
R1516 T2123 T2097 punct .,indicates
R3371 T4688 T4687 prep of,Expression
R3372 T4689 T4690 amod Endogenous,Transgene
R3373 T4690 T4688 pobj Transgene,of
R3374 T4691 T4690 nmod PPARδ,Transgene
R3375 T4692 T4691 cc and,PPARδ
R3376 T4693 T4694 compound VP16,PPARδ
R3377 T4694 T4691 conj PPARδ,PPARδ
R3378 T4695 T4694 punct -,PPARδ
R3379 T4696 T4687 prep in,Expression
R3380 T4697 T4696 pobj Muscle,in
R3381 T4699 T4700 punct (,A
R3382 T4700 T4701 meta A,hybridized
R3383 T4702 T4700 punct ),A
R3384 T4703 T4704 amod Pooled,RNA
R3385 T4704 T4701 nsubjpass RNA,hybridized
R3386 T4705 T4704 acl isolated,RNA
R3387 T4706 T4705 prep from,isolated
R3388 T4707 T4708 amod various,muscles
R3389 T4708 T4706 pobj muscles,from
R3390 T4709 T4708 prep of,muscles
R3391 T4710 T4711 nummod five,mice
R3392 T4711 T4709 pobj mice,of
R3393 T4712 T4713 amod wild,type
R3394 T4713 T4711 nmod type,mice
R3395 T4714 T4713 punct -,type
R3396 T4715 T4711 amod male,mice
R3397 T4716 T4711 compound C57B6,mice
R3398 T4717 T4701 auxpass was,hybridized
R3399 T4718 T4701 prep with,hybridized
R3400 T4719 T4720 amod indicated,probes
R3401 T4720 T4718 pobj probes,with
R3402 T4721 T4701 punct .,hybridized
R3403 T4724 T4723 punct ", ",EDL
R3404 T4725 T4726 compound extensor,longus
R3405 T4726 T4723 appos longus,EDL
R3406 T4727 T4726 compound digitorum,longus
R3407 T4728 T4723 punct ;,EDL
R3408 T4729 T4723 appos Gastro,EDL
R3409 T4730 T4729 punct ", ",Gastro
R3410 T4731 T4729 appos gastrocnemius,Gastro
R3411 T4732 T4723 punct .,EDL
R3412 T4734 T4735 punct (,B
R3413 T4735 T4736 meta B,probed
R3414 T4737 T4735 punct ),B
R3415 T4738 T4739 amod Pooled,proteins
R3416 T4739 T4736 nsubjpass proteins,probed
R3417 T4740 T4739 amod nuclear,proteins
R3418 T4741 T4742 punct (,μg
R3419 T4742 T4739 parataxis μg,proteins
R3420 T4743 T4742 nummod 15,μg
R3421 T4744 T4745 punct /,lane
R3422 T4745 T4742 prep lane,μg
R3423 T4746 T4742 punct ),μg
R3424 T4747 T4739 acl isolated,proteins
R3425 T4748 T4747 prep from,isolated
R3426 T4749 T4748 pobj muscles,from
R3427 T4750 T4749 prep of,muscles
R3428 T4751 T4752 nummod five,C57B6
R3429 T4752 T4750 pobj C57B6,of
R3430 T4753 T4754 amod wild,type
R3431 T4754 T4752 nmod type,C57B6
R3432 T4755 T4754 punct -,type
R3433 T4756 T4752 amod male,C57B6
R3434 T4757 T4736 auxpass were,probed
R3435 T4758 T4736 prep with,probed
R3436 T4759 T4760 amod anti-PPARδ,antibody
R3437 T4760 T4758 pobj antibody,with
R3438 T4761 T4736 punct .,probed
R3439 T4763 T4764 compound RNA,polymerase
R3440 T4764 T4765 nsubjpass polymerase,shown
R3441 T4766 T4764 nummod II,polymerase
R3442 T4767 T4764 punct (,polymerase
R3443 T4768 T4764 appos Pol,polymerase
R3444 T4769 T4768 nummod II,Pol
R3445 T4770 T4764 punct ),polymerase
R3446 T4771 T4765 auxpass is,shown
R3447 T4772 T4765 prep as,shown
R3448 T4773 T4774 det a,control
R3449 T4774 T4772 pobj control,as
R3450 T4775 T4774 compound loading,control
R3451 T4776 T4765 punct .,shown
R3452 T4778 T4779 punct (,C
R3453 T4779 T4780 meta C,Expression
R3454 T4781 T4779 punct ),C
R3455 T4782 T4780 prep of,Expression
R3456 T4783 T4784 det the,transgene
R3457 T4784 T4782 pobj transgene,of
R3458 T4785 T4786 compound VP16,PPARδ
R3459 T4786 T4784 compound PPARδ,transgene
R3460 T4787 T4786 punct -,PPARδ
R3461 T4788 T4780 prep in,Expression
R3462 T4789 T4790 amod various,tissues
R3463 T4790 T4788 pobj tissues,in
R3464 T4791 T4780 punct .,Expression
R3465 T4793 T4794 nummod 10,μg
R3466 T4794 T4795 nsubjpass μg,hybridized
R3467 T4796 T4794 prep of,μg
R3468 T4797 T4798 amod total,RNA
R3469 T4798 T4796 pobj RNA,of
R3470 T4799 T4798 prep from,RNA
R3471 T4800 T4801 det each,tissue
R3472 T4801 T4799 pobj tissue,from
R3473 T4802 T4795 auxpass was,hybridized
R3474 T4803 T4795 prep with,hybridized
R3475 T4804 T4805 det a,probe
R3476 T4805 T4803 pobj probe,with
R3477 T4806 T4807 compound VP16,cDNA
R3478 T4807 T4805 compound cDNA,probe
R3479 T4808 T4795 punct .,hybridized
R3480 T4810 T4811 compound Gastrocnemius,muscle
R3481 T4811 T4812 nsubjpass muscle,used
R3482 T4813 T4812 auxpass was,used
R3483 T4814 T4812 advmod here,used
R3484 T4815 T4812 punct .,used
R3485 T4817 T4818 punct (,D
R3486 T4818 T4819 meta D,probed
R3487 T4820 T4818 punct ),D
R3488 T4821 T4822 amod Nuclear,proteins
R3489 T4822 T4819 nsubjpass proteins,probed
R3490 T4823 T4824 punct (,μg
R3491 T4824 T4822 parataxis μg,proteins
R3492 T4825 T4824 nummod 15,μg
R3493 T4826 T4827 punct /,lane
R3494 T4827 T4824 prep lane,μg
R3495 T4828 T4824 punct ),μg
R3496 T4829 T4822 acl isolated,proteins
R3497 T4830 T4829 prep from,isolated
R3498 T4831 T4832 compound gastrocnemius,muscle
R3499 T4832 T4830 pobj muscle,from
R3500 T4833 T4832 prep of,muscle
R3501 T4834 T4835 det the,mice
R3502 T4835 T4833 pobj mice,of
R3503 T4836 T4835 amod transgenic,mice
R3504 T4837 T4838 punct (,TG
R3505 T4838 T4835 parataxis TG,mice
R3506 T4839 T4838 punct ),TG
R3507 T4840 T4835 cc and,mice
R3508 T4841 T4842 det the,littermates
R3509 T4842 T4835 conj littermates,mice
R3510 T4843 T4844 amod wild,type
R3511 T4844 T4842 compound type,littermates
R3512 T4845 T4844 punct -,type
R3513 T4846 T4847 punct (,WT
R3514 T4847 T4842 parataxis WT,littermates
R3515 T4848 T4847 punct ),WT
R3516 T4849 T4819 auxpass were,probed
R3517 T4850 T4819 prep with,probed
R3518 T4851 T4852 amod indicated,antibodies
R3519 T4852 T4850 pobj antibodies,with
R3520 T4853 T4819 punct .,probed
R3521 T4855 T4856 det The,band
R3522 T4856 T4860 nsubj band,serves
R3523 T4857 T4856 amod upper,band
R3524 T4858 T4856 punct ", ",band
R3525 T4859 T4856 amod nonspecific,band
R3526 T4861 T4862 dep that,cross-reacted
R3527 T4862 T4856 relcl cross-reacted,band
R3528 T4863 T4862 prep with,cross-reacted
R3529 T4864 T4865 det the,antibody
R3530 T4865 T4863 pobj antibody,with
R3531 T4866 T4865 amod anti-PPARδ,antibody
R3532 T4867 T4868 det a,control
R3533 T4868 T4860 dobj control,serves
R3534 T4869 T4868 compound loading,control
R3535 T4870 T4860 punct .,serves
R3536 T4894 T4895 amod Increased,Fibers
R3537 T4896 T4895 amod Oxidative,Fibers
R3538 T4897 T4895 nmod Type,Fibers
R3539 T4898 T4897 nummod I,Type
R3540 T4899 T4895 prep in,Fibers
R3541 T4900 T4901 det the,Mice
R3542 T4901 T4899 pobj Mice,in
R3543 T4902 T4901 amod Transgenic,Mice
R3544 T4904 T4905 punct (,A
R3545 T4905 T4906 meta A,are
R3546 T4907 T4905 cc and,A
R3547 T4908 T4905 conj B,A
R3548 T4909 T4908 punct ),B
R3549 T4910 T4906 nsubj Muscles,are
R3550 T4911 T4910 prep in,Muscles
R3551 T4912 T4913 amod transgenic,mice
R3552 T4913 T4911 pobj mice,in
R3553 T4914 T4915 punct (,TG
R3554 T4915 T4913 parataxis TG,mice
R3555 T4916 T4915 punct ),TG
R3556 T4917 T4906 acomp redder,are
R3557 T4918 T4917 prep than,redder
R3558 T4919 T4918 pobj those,than
R3559 T4920 T4919 prep in,those
R3560 T4921 T4922 amod wild,type
R3561 T4922 T4924 compound type,mice
R3562 T4923 T4922 punct -,type
R3563 T4924 T4920 pobj mice,in
R3564 T4925 T4926 punct (,WT
R3565 T4926 T4924 parataxis WT,mice
R3566 T4927 T4926 punct ),WT
R3567 T4928 T4906 punct .,are
R3568 T4930 T4931 punct (,C
R3569 T4931 T4932 meta C,staining
R3570 T4933 T4931 punct ),C
R3571 T4934 T4932 amod Metachromatic,staining
R3572 T4935 T4932 prep of,staining
R3573 T4936 T4937 det the,muscle
R3574 T4937 T4935 pobj muscle,of
R3575 T4938 T4937 nmod type,muscle
R3576 T4939 T4938 nummod II,type
R3577 T4940 T4937 compound plantaris,muscle
R3578 T4941 T4932 punct .,staining
R3579 T4943 T4944 nmod Type,fibers
R3580 T4944 T4946 nsubjpass fibers,stained
R3581 T4945 T4943 nummod I,Type
R3582 T4947 T4946 auxpass are,stained
R3583 T4948 T4949 advmod dark,blue
R3584 T4949 T4946 oprd blue,stained
R3585 T4950 T4946 punct .,stained
R3586 T5034 T5035 nsubj Activation,Induces
R3587 T5036 T5034 prep of,Activation
R3588 T5037 T5036 pobj PPARδ,of
R3589 T5038 T5035 dobj Genes,Induces
R3590 T5039 T5038 amod Typical,Genes
R3591 T5040 T5039 prep for,Typical
R3592 T5041 T5042 nmod Type,Fibers
R3593 T5042 T5040 pobj Fibers,for
R3594 T5043 T5041 nummod I,Type
R3595 T5044 T5035 cc and,Induces
R3596 T5045 T5035 conj Promotes,Induces
R3597 T5046 T5047 amod Mitochondrial,Biogenesis
R3598 T5047 T5045 dobj Biogenesis,Promotes
R3599 T5049 T5050 punct (,A
R3600 T5050 T5051 meta A,probed
R3601 T5052 T5050 punct ),A
R3602 T5053 T5054 amod Total,RNA
R3603 T5054 T5051 nsubjpass RNA,probed
R3604 T5055 T5056 punct (,μg
R3605 T5056 T5054 parataxis μg,RNA
R3606 T5057 T5056 nummod 10,μg
R3607 T5058 T5059 punct /,lane
R3608 T5059 T5056 prep lane,μg
R3609 T5060 T5056 punct ),μg
R3610 T5061 T5054 acl prepared,RNA
R3611 T5062 T5061 prep from,prepared
R3612 T5063 T5064 compound gastrocnemius,muscle
R3613 T5064 T5062 pobj muscle,from
R3614 T5065 T5064 prep of,muscle
R3615 T5066 T5067 amod transgenic,littermates
R3616 T5067 T5065 pobj littermates,of
R3617 T5068 T5069 punct (,TG
R3618 T5069 T5066 parataxis TG,transgenic
R3619 T5070 T5069 punct ),TG
R3620 T5071 T5066 cc and,transgenic
R3621 T5072 T5073 amod wild,type
R3622 T5073 T5066 conj type,transgenic
R3623 T5074 T5073 punct -,type
R3624 T5075 T5076 punct (,WT
R3625 T5076 T5073 parataxis WT,type
R3626 T5077 T5076 punct ),WT
R3627 T5078 T5051 auxpass was,probed
R3628 T5079 T5051 prep with,probed
R3629 T5080 T5081 amod indicated,probes
R3630 T5081 T5079 pobj probes,with
R3631 T5082 T5051 punct .,probed
R3632 T5084 T5085 det The,increase
R3633 T5085 T5087 nsubjpass increase,shown
R3634 T5086 T5085 amod fold,increase
R3635 T5088 T5085 prep of,increase
R3636 T5089 T5088 pobj induction,of
R3637 T5090 T5089 prep of,induction
R3638 T5091 T5092 det each,gene
R3639 T5092 T5090 pobj gene,of
R3640 T5093 T5087 auxpass is,shown
R3641 T5094 T5087 punct .,shown
R3642 T5096 T5097 punct (,B
R3643 T5097 T5098 meta B,digested
R3644 T5099 T5097 punct ),B
R3645 T5100 T5101 amod Total,DNA
R3646 T5101 T5098 nsubjpass DNA,digested
R3647 T5102 T5101 amod genomic,DNA
R3648 T5103 T5104 punct (,μg
R3649 T5104 T5101 parataxis μg,DNA
R3650 T5105 T5104 nummod 10,μg
R3651 T5106 T5107 punct /,lane
R3652 T5107 T5104 prep lane,μg
R3653 T5108 T5104 punct ),μg
R3654 T5109 T5101 acl prepared,DNA
R3655 T5110 T5109 prep from,prepared
R3656 T5111 T5112 compound gastrocnemius,muscle
R3657 T5112 T5110 pobj muscle,from
R3658 T5113 T5098 auxpass was,digested
R3659 T5114 T5098 prep with,digested
R3660 T5115 T5114 pobj Nco1,with
R3661 T5116 T5098 cc and,digested
R3662 T5117 T5098 conj subjected,digested
R3663 T5118 T5117 prep to,subjected
R3664 T5119 T5120 compound Southern,analysis
R3665 T5120 T5118 pobj analysis,to
R3666 T5121 T5117 prep with,subjected
R3667 T5122 T5123 nmod COXII,probes
R3668 T5123 T5121 pobj probes,with
R3669 T5124 T5125 punct (,encoded
R3670 T5125 T5122 parataxis encoded,COXII
R3671 T5126 T5127 amod mitochondrial,genome
R3672 T5127 T5125 npadvmod genome,encoded
R3673 T5128 T5125 punct –,encoded
R3674 T5129 T5125 punct ),encoded
R3675 T5130 T5122 cc and,COXII
R3676 T5131 T5122 conj MCIP1,COXII
R3677 T5132 T5133 punct (,encoded
R3678 T5133 T5131 parataxis encoded,MCIP1
R3679 T5134 T5135 amod nuclear,genome
R3680 T5135 T5133 npadvmod genome,encoded
R3681 T5136 T5133 punct –,encoded
R3682 T5137 T5133 punct ),encoded
R3683 T5138 T5123 compound DNA,probes
R3684 T5139 T5098 punct .,digested
R3685 T5141 T5142 punct (,C
R3686 T5142 T5143 meta C,collected
R3687 T5144 T5142 punct ),C
R3688 T5145 T5146 amod Equal,amounts
R3689 T5146 T5143 nsubjpass amounts,collected
R3690 T5147 T5146 prep of,amounts
R3691 T5148 T5149 compound gastrocnemius,muscle
R3692 T5149 T5147 pobj muscle,of
R3693 T5150 T5143 auxpass were,collected
R3694 T5151 T5143 prep from,collected
R3695 T5152 T5153 preconj both,mice
R3696 T5153 T5151 pobj mice,from
R3697 T5154 T5153 amod transgenic,mice
R3698 T5155 T5153 cc and,mice
R3699 T5156 T5157 compound control,littermates
R3700 T5157 T5153 conj littermates,mice
R3701 T5158 T5143 punct .,collected
R3702 T5160 T5161 amod Total,DNA
R3703 T5161 T5163 nsubjpass DNA,isolated
R3704 T5162 T5161 amod mitochondrial,DNA
R3705 T5164 T5163 auxpass was,isolated
R3706 T5165 T5163 cc and,isolated
R3707 T5166 T5163 conj separated,isolated
R3708 T5167 T5166 prep on,separated
R3709 T5168 T5169 nummod 1,%
R3710 T5169 T5170 compound %,gel
R3711 T5170 T5167 pobj gel,on
R3712 T5171 T5170 compound agarose,gel
R3713 T5172 T5163 punct .,isolated
R3714 T5174 T5175 det The,abundance
R3715 T5175 T5177 nsubjpass abundance,presented
R3716 T5176 T5175 amod relative,abundance
R3717 T5178 T5175 prep of,abundance
R3718 T5179 T5180 amod mitochondrial,DNA
R3719 T5180 T5178 pobj DNA,of
R3720 T5181 T5175 prep in,abundance
R3721 T5182 T5183 amod transgenic,mice
R3722 T5183 T5181 pobj mice,in
R3723 T5184 T5182 cc and,transgenic
R3724 T5185 T5186 amod wild,type
R3725 T5186 T5182 conj type,transgenic
R3726 T5187 T5186 punct -,type
R3727 T5188 T5177 auxpass is,presented
R3728 T5189 T5177 punct .,presented
R3729 T5191 T5192 punct (,D
R3730 T5192 T5193 meta D,analysis
R3731 T5194 T5192 punct ),D
R3732 T5195 T5196 compound Western,blot
R3733 T5196 T5193 compound blot,analysis
R3734 T5197 T5193 prep of,analysis
R3735 T5198 T5199 compound muscle,fiber
R3736 T5199 T5200 compound fiber,markers
R3737 T5200 T5197 pobj markers,of
R3738 T5201 T5200 cc and,markers
R3739 T5202 T5203 amod mitochondrial,components
R3740 T5203 T5200 conj components,markers
R3741 T5204 T5193 punct .,analysis
R3742 T5206 T5207 det Each,lane
R3743 T5207 T5208 nsubjpass lane,loaded
R3744 T5209 T5208 auxpass was,loaded
R3745 T5210 T5208 prep with,loaded
R3746 T5211 T5212 nummod 80,μg
R3747 T5212 T5210 pobj μg,with
R3748 T5213 T5212 prep of,μg
R3749 T5214 T5215 amod total,extracts
R3750 T5215 T5213 pobj extracts,of
R3751 T5216 T5217 compound gastrocnemius,muscle
R3752 T5217 T5215 compound muscle,extracts
R3753 T5218 T5208 punct .,loaded
R3754 T5220 T5221 punct (,E
R3755 T5221 T5222 meta E,treated
R3756 T5223 T5221 punct ),E
R3757 T5224 T5225 amod Wild,type
R3758 T5225 T5227 compound type,mice
R3759 T5226 T5225 punct -,type
R3760 T5227 T5222 nsubjpass mice,treated
R3761 T5228 T5227 compound C57B6,mice
R3762 T5229 T5222 auxpass were,treated
R3763 T5230 T5222 prep with,treated
R3764 T5231 T5230 pobj vehicle,with
R3765 T5232 T5231 cc or,vehicle
R3766 T5233 T5234 compound PPARδ,agonist
R3767 T5234 T5235 compound agonist,GW501516
R3768 T5235 T5231 conj GW501516,vehicle
R3769 T5236 T5222 prep for,treated
R3770 T5237 T5238 nummod 10,d
R3771 T5238 T5236 pobj d,for
R3772 T5239 T5222 punct .,treated
R3773 T5241 T5242 amod Total,RNA
R3774 T5242 T5243 nsubjpass RNA,probed
R3775 T5244 T5245 punct (,μg
R3776 T5245 T5242 parataxis μg,RNA
R3777 T5246 T5245 nummod 10,μg
R3778 T5247 T5248 punct /,lane
R3779 T5248 T5245 prep lane,μg
R3780 T5249 T5245 punct ),μg
R3781 T5250 T5242 acl prepared,RNA
R3782 T5251 T5250 prep from,prepared
R3783 T5252 T5253 det the,muscle
R3784 T5253 T5251 pobj muscle,from
R3785 T5254 T5253 compound gastrocnemius,muscle
R3786 T5255 T5243 auxpass was,probed
R3787 T5256 T5243 prep with,probed
R3788 T5257 T5258 amod indicated,probes
R3789 T5258 T5256 pobj probes,with
R3790 T5259 T5243 punct .,probed
R723 T1279 T1280 nsubj Activation,Leads
R724 T1281 T1279 prep of,Activation
R725 T1282 T1281 pobj PPARδ,of
R726 T1283 T1280 prep to,Leads
R727 T1284 T1285 compound Muscle,Fiber
R728 T1285 T1286 compound Fiber,Transformation
R729 T1286 T1283 pobj Transformation,to
R730 T1288 T1289 det A,role
R731 T1289 T1290 nsubjpass role,suggested
R732 T1291 T1289 prep of,role
R733 T1292 T1291 pobj PPARδ,of
R734 T1293 T1289 prep in,role
R735 T1294 T1295 compound muscle,fiber
R736 T1295 T1293 pobj fiber,in
R737 T1296 T1290 auxpass was,suggested
R738 T1297 T1290 agent by,suggested
R739 T1298 T1299 poss its,expression
R740 T1299 T1297 pobj expression,by
R741 T1300 T1299 amod enhanced,expression
R742 T1301 T1299 punct —,expression
R743 T1302 T1299 prep at,expression
R744 T1303 T1302 pobj levels,at
R745 T1304 T1305 npadvmod 10,greater
R746 T1305 T1303 amod greater,levels
R747 T1306 T1304 punct -,10
R748 T1307 T1304 advmod fold,10
R749 T1308 T1304 cc and,10
R750 T1309 T1304 conj 50,10
R751 T1310 T1309 punct -,50
R752 T1311 T1309 advmod fold,50
R753 T1312 T1305 prep than,greater
R754 T1313 T1314 nmod PPARα,isoforms
R755 T1314 T1312 pobj isoforms,than
R756 T1315 T1313 cc and,PPARα
R757 T1316 T1313 punct γ,PPARα
R758 T1317 T1290 punct ", ",suggested
R759 T1318 T1290 advmod respectively,suggested
R760 T1319 T1320 punct (,data
R761 T1320 T1290 parataxis data,suggested
R762 T1321 T1320 amod unpublished,data
R763 T1322 T1320 punct ),data
R764 T1323 T1290 punct .,suggested
R765 T1325 T1326 det An,examination
R766 T1326 T1327 nsubj examination,reveals
R767 T1327 T1334 ccomp reveals,resembles
R768 T1328 T1326 prep of,examination
R769 T1329 T1328 pobj PPARδ,of
R770 T1330 T1326 prep in,examination
R771 T1331 T1332 amod different,fibers
R772 T1332 T1330 pobj fibers,in
R773 T1333 T1332 compound muscle,fibers
R774 T1335 T1336 det a,level
R775 T1336 T1327 dobj level,reveals
R776 T1337 T1338 advmod significantly,higher
R777 T1338 T1336 amod higher,level
R778 T1339 T1327 prep in,reveals
R779 T1340 T1341 nmod type,muscle
R780 T1341 T1339 pobj muscle,in
R781 T1342 T1340 nummod I,type
R782 T1343 T1344 punct (,soleus
R783 T1344 T1341 parataxis soleus,muscle
R784 T1345 T1344 punct ),soleus
R785 T1346 T1327 advcl relative,reveals
R786 T1347 T1346 prep to,relative
R787 T1348 T1349 npadvmod type,rich
R788 T1349 T1352 amod rich,muscle
R789 T1350 T1348 nummod II,type
R790 T1351 T1349 punct –,rich
R791 T1352 T1347 pobj muscle,to
R792 T1353 T1354 punct (,longus
R793 T1354 T1352 parataxis longus,muscle
R794 T1355 T1354 compound extensor,longus
R795 T1356 T1354 compound digitorum,longus
R796 T1357 T1354 punct ),longus
R797 T1358 T1352 cc or,muscle
R798 T1359 T1360 nmod type,muscle
R799 T1360 T1352 conj muscle,muscle
R800 T1361 T1359 nummod I,type
R801 T1362 T1359 cc and,type
R802 T1363 T1359 conj type,type
R803 T1364 T1363 nummod II,type
R804 T1365 T1360 amod mixed,muscle
R805 T1366 T1367 punct (,gastrocnemius
R806 T1367 T1360 parataxis gastrocnemius,muscle
R807 T1368 T1367 punct ),gastrocnemius
R808 T1369 T1370 punct (,Figure
R809 T1370 T1327 parataxis Figure,reveals
R810 T1371 T1370 nummod 1A,Figure
R811 T1372 T1370 punct ),Figure
R812 T1373 T1334 punct ;,resembles
R813 T1374 T1375 det this,pattern
R814 T1375 T1334 nsubj pattern,resembles
R815 T1376 T1375 compound expression,pattern
R816 T1377 T1334 advmod closely,resembles
R817 T1378 T1334 dobj that,resembles
R818 T1379 T1378 prep of,that
R819 T1380 T1379 pobj PGC,of
R820 T1381 T1380 punct -,PGC
R821 T1382 T1380 nummod 1α,PGC
R822 T1383 T1384 punct (,Lin
R823 T1384 T1334 meta Lin,resembles
R824 T1385 T1384 nmod et,Lin
R825 T1386 T1384 nmod al.,Lin
R826 T1387 T1384 nummod 2002,Lin
R827 T1388 T1384 punct ),Lin
R828 T1389 T1334 punct .,resembles
R829 T1391 T1392 det A,pattern
R830 T1392 T1394 nsubjpass pattern,found
R831 T1393 T1392 amod similar,pattern
R832 T1395 T1396 cc but,with
R833 T1396 T1392 nmod with,pattern
R834 T1397 T1398 advmod more,pronounced
R835 T1398 T1399 amod pronounced,differences
R836 T1399 T1396 pobj differences,with
R837 T1400 T1394 auxpass was,found
R838 T1401 T1394 prep at,found
R839 T1402 T1403 det the,level
R840 T1403 T1401 pobj level,at
R841 T1404 T1403 compound protein,level
R842 T1405 T1406 punct (,Figure
R843 T1406 T1394 parataxis Figure,found
R844 T1407 T1406 nummod 1B,Figure
R845 T1408 T1406 punct ),Figure
R846 T1409 T1394 punct .,found
R847 T1411 T1412 aux To,assess
R848 T1412 T1414 advcl assess,generated
R849 T1413 T1412 advmod directly,assess
R850 T1415 T1416 det the,role
R851 T1416 T1412 dobj role,assess
R852 T1417 T1416 prep of,role
R853 T1418 T1417 pobj activation,of
R854 T1419 T1418 prep of,activation
R855 T1420 T1419 pobj PPARδ,of
R856 T1421 T1416 prep in,role
R857 T1422 T1421 pobj control,in
R858 T1423 T1422 prep of,control
R859 T1424 T1425 compound muscle,fiber
R860 T1425 T1426 compound fiber,plasticity
R861 T1426 T1423 pobj plasticity,of
R862 T1427 T1426 cc and,plasticity
R863 T1428 T1429 amod mitochondrial,biogenesis
R864 T1429 T1426 conj biogenesis,plasticity
R865 T1430 T1414 punct ", ",generated
R866 T1431 T1414 nsubj we,generated
R867 T1432 T1414 dobj mice,generated
R868 T1433 T1432 acl expressing,mice
R869 T1434 T1435 det a,transgene
R870 T1435 T1433 dobj transgene,expressing
R871 T1436 T1437 prep in,fused
R872 T1437 T1435 relcl fused,transgene
R873 T1438 T1436 pobj which,in
R874 T1439 T1440 det the,domain
R875 T1440 T1437 nsubjpass domain,fused
R876 T1441 T1442 nummod 78,acid
R877 T1442 T1440 compound acid,domain
R878 T1443 T1442 punct -,acid
R879 T1444 T1442 compound amino,acid
R880 T1445 T1442 punct -,acid
R881 T1446 T1447 compound VP16,activation
R882 T1447 T1440 compound activation,domain
R883 T1448 T1437 auxpass was,fused
R884 T1449 T1437 prep to,fused
R885 T1450 T1451 det the,terminus
R886 T1451 T1449 pobj terminus,to
R887 T1452 T1451 compound N,terminus
R888 T1453 T1451 punct -,terminus
R889 T1454 T1451 prep of,terminus
R890 T1455 T1456 amod full,length
R891 T1456 T1458 compound length,PPARδ
R892 T1457 T1456 punct -,length
R893 T1458 T1454 pobj PPARδ,of
R894 T1459 T1437 punct ", ",fused
R895 T1460 T1437 prep under,fused
R896 T1461 T1460 pobj control,under
R897 T1462 T1461 prep of,control
R898 T1463 T1464 det the,promoter
R899 T1464 T1462 pobj promoter,of
R900 T1465 T1466 nummod 2.2,kb
R901 T1466 T1464 nmod kb,promoter
R902 T1467 T1466 punct -,kb
R903 T1468 T1464 amod human,promoter
R904 T1469 T1470 npadvmod α,skeletal
R905 T1470 T1464 amod skeletal,promoter
R906 T1471 T1470 punct -,skeletal
R907 T1472 T1464 compound actin,promoter
R908 T1473 T1414 punct .,generated
R909 T1475 T1476 prep In,expressed
R910 T1477 T1475 pobj agreement,In
R911 T1478 T1477 prep with,agreement
R912 T1479 T1480 det the,characterization
R913 T1480 T1478 pobj characterization,with
R914 T1481 T1480 amod previous,characterization
R915 T1482 T1480 prep of,characterization
R916 T1483 T1484 det this,promoter
R917 T1484 T1482 pobj promoter,of
R918 T1485 T1486 punct (,Brennan
R919 T1486 T1480 meta Brennan,characterization
R920 T1487 T1486 cc and,Brennan
R921 T1488 T1486 conj Hardeman,Brennan
R922 T1489 T1488 nummod 1993,Hardeman
R923 T1490 T1488 punct ;,Hardeman
R924 T1491 T1488 conj Clapham,Hardeman
R925 T1492 T1491 nmod et,Clapham
R926 T1493 T1491 nmod al.,Clapham
R927 T1494 T1491 nummod 2000,Clapham
R928 T1495 T1491 punct ),Clapham
R929 T1496 T1476 punct ", ",expressed
R930 T1497 T1498 det the,transgene
R931 T1498 T1476 nsubjpass transgene,expressed
R932 T1499 T1500 compound VP16,PPARδ
R933 T1500 T1498 compound PPARδ,transgene
R934 T1501 T1500 punct -,PPARδ
R935 T1502 T1476 auxpass was,expressed
R936 T1503 T1476 advmod selectively,expressed
R937 T1504 T1476 prep in,expressed
R938 T1505 T1506 amod skeletal,muscle
R939 T1506 T1504 pobj muscle,in
R940 T1507 T1476 punct ", ",expressed
R941 T1508 T1509 mark with,less
R942 T1509 T1476 advcl less,expressed
R943 T1510 T1509 nummod 10,less
R944 T1511 T1510 punct -,10
R945 T1512 T1510 advmod fold,10
R946 T1513 T1509 prep in,less
R947 T1514 T1515 det the,heart
R948 T1515 T1513 pobj heart,in
R949 T1516 T1517 punct (,Figure
R950 T1517 T1476 parataxis Figure,expressed
R951 T1518 T1517 nummod 1C,Figure
R952 T1519 T1517 punct ),Figure
R953 T1520 T1476 punct .,expressed
R954 T1522 T1523 prep Among,appeared
R955 T1524 T1525 amod different,types
R956 T1525 T1522 pobj types,Among
R957 T1526 T1525 prep of,types
R958 T1527 T1528 compound muscle,fibers
R959 T1528 T1526 pobj fibers,of
R960 T1529 T1523 punct ", ",appeared
R961 T1530 T1531 det the,levels
R962 T1531 T1523 nsubj levels,appeared
R963 T1532 T1531 prep of,levels
R964 T1533 T1534 compound VP16,PPARδ
R965 T1534 T1536 compound PPARδ,expression
R966 T1535 T1534 punct -,PPARδ
R967 T1536 T1532 pobj expression,of
R968 T1537 T1538 aux to,be
R969 T1538 T1523 xcomp be,appeared
R970 T1539 T1538 acomp similar,be
R971 T1540 T1541 punct (,data
R972 T1541 T1538 parataxis data,be
R973 T1542 T1541 amod unpublished,data
R974 T1543 T1541 punct ),data
R975 T1544 T1523 punct .,appeared
R976 T1546 T1547 mark As,shown
R977 T1547 T1548 advcl shown,produced
R978 T1549 T1547 prep in,shown
R979 T1550 T1549 pobj Figure,in
R980 T1551 T1550 nummod 1D,Figure
R981 T1552 T1547 prep for,shown
R982 T1553 T1554 compound gastrocnemius,muscle
R983 T1554 T1552 pobj muscle,for
R984 T1555 T1548 punct ", ",produced
R985 T1556 T1557 compound VP16,PPARδ
R986 T1557 T1559 compound PPARδ,protein
R987 T1558 T1557 punct -,PPARδ
R988 T1559 T1548 nsubjpass protein,produced
R989 T1560 T1559 compound fusion,protein
R990 T1561 T1548 auxpass was,produced
R991 T1562 T1548 prep at,produced
R992 T1563 T1564 det a,level
R993 T1564 T1562 pobj level,at
R994 T1565 T1564 amod similar,level
R995 T1566 T1565 prep to,similar
R996 T1567 T1566 pobj that,to
R997 T1568 T1567 prep of,that
R998 T1569 T1570 amod endogenous,PPARδ
R999 T1570 T1568 pobj PPARδ,of