craft-sa-dev Home  

PMC:509410 / 21194-22269 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T4058 0-7 NNS denotes Animals
T4059 7-8 . denotes .
T4060 8-158 sentence denotes The transactivation domain (78 amino acid residues, corresponding to residues 413–490) of VP16 was fused in frame with the N-terminus of mouse PPARδ.
T4061 9-12 DT denotes The
T4063 13-28 NN denotes transactivation
T4062 29-35 NN denotes domain
T4065 36-37 -LRB- denotes (
T4067 37-39 CD denotes 78
T4068 40-45 NN denotes amino
T4069 46-50 NN denotes acid
T4066 51-59 NNS denotes residues
T4070 59-61 , denotes ,
T4071 61-74 VBG denotes corresponding
T4072 75-77 IN denotes to
T4073 78-86 NNS denotes residues
T4074 87-90 CD denotes 413
T4075 90-91 SYM denotes –
T4076 91-94 CD denotes 490
T4077 94-95 -RRB- denotes )
T4078 96-98 IN denotes of
T4079 99-103 NN denotes VP16
T4080 104-107 VBD denotes was
T4064 108-113 VBN denotes fused
T4081 114-116 IN denotes in
T4082 117-122 NN denotes frame
T4083 123-127 IN denotes with
T4084 128-131 DT denotes the
T4086 132-133 NN denotes N
T4087 133-134 HYPH denotes -
T4085 134-142 NN denotes terminus
T4088 143-145 IN denotes of
T4089 146-151 NN denotes mouse
T4090 152-157 NN denotes PPARδ
T4091 157-158 . denotes .
T4092 158-325 sentence denotes The VP16-PPARδ fusion cDNA was placed downstream of the human α-skeletal actin promoter (Brennan and Hardeman 1993), and upstream of the SV40 intron/poly(A) sequence.
T4093 159-162 DT denotes The
T4095 163-167 NN denotes VP16
T4097 167-168 HYPH denotes -
T4096 168-173 NN denotes PPARδ
T4098 174-180 NN denotes fusion
T4094 181-185 NN denotes cDNA
T4100 186-189 VBD denotes was
T4099 190-196 VBN denotes placed
T4101 197-207 RB denotes downstream
T4102 208-210 IN denotes of
T4103 211-214 DT denotes the
T4105 215-220 JJ denotes human
T4106 221-222 NN denotes α
T4108 222-223 HYPH denotes -
T4107 223-231 JJ denotes skeletal
T4109 232-237 NN denotes actin
T4104 238-246 NN denotes promoter
T4110 247-248 -LRB- denotes (
T4111 248-255 NNP denotes Brennan
T4112 256-259 CC denotes and
T4113 260-268 NNP denotes Hardeman
T4114 269-273 CD denotes 1993
T4115 273-274 -RRB- denotes )
T4116 274-276 , denotes ,
T4117 276-279 CC denotes and
T4118 280-288 RB denotes upstream
T4119 289-291 IN denotes of
T4120 292-295 DT denotes the
T4122 296-300 NN denotes SV40
T4123 301-307 NN denotes intron
T4124 307-308 HYPH denotes /
T4125 308-312 NN denotes poly
T4127 312-313 -LRB- denotes (
T4126 313-314 NN denotes A
T4128 314-315 -RRB- denotes )
T4121 316-324 NN denotes sequence
T4129 324-325 . denotes .
T4130 325-397 sentence denotes The transgene was purified and injected into C57BL/6J × CBA F1 zygotes.
T4131 326-329 DT denotes The
T4132 330-339 NN denotes transgene
T4134 340-343 VBD denotes was
T4133 344-352 VBN denotes purified
T4135 353-356 CC denotes and
T4136 357-365 VBN denotes injected
T4137 366-370 IN denotes into
T4138 371-376 NN denotes C57BL
T4140 376-377 HYPH denotes /
T4139 377-379 NN denotes 6J
T4142 380-381 SYM denotes ×
T4143 382-385 NN denotes CBA
T4144 386-388 NN denotes F1
T4141 389-396 NNS denotes zygotes
T4145 396-397 . denotes .
T4146 397-465 sentence denotes Transgenic mice were backcrossed with C57BL/6J for two generations.
T4147 398-408 JJ denotes Transgenic
T4148 409-413 NNS denotes mice
T4150 414-418 VBD denotes were
T4149 419-430 VBN denotes backcrossed
T4151 431-435 IN denotes with
T4152 436-441 NN denotes C57BL
T4154 441-442 HYPH denotes /
T4153 442-444 NN denotes 6J
T4155 445-448 IN denotes for
T4156 449-452 CD denotes two
T4157 453-464 NNS denotes generations
T4158 464-465 . denotes .
T4159 465-531 sentence denotes Wild-type littermates were used as controls throughout the study.
T4160 466-470 JJ denotes Wild
T4162 470-471 HYPH denotes -
T4161 471-475 NN denotes type
T4163 476-487 NNS denotes littermates
T4165 488-492 VBD denotes were
T4164 493-497 VBN denotes used
T4166 498-500 IN denotes as
T4167 501-509 NNS denotes controls
T4168 510-520 IN denotes throughout
T4169 521-524 DT denotes the
T4170 525-530 NN denotes study
T4171 530-531 . denotes .
T4172 531-632 sentence denotes On normal chow diet, the transgenic mice and control littermates used here had similar body weights.
T4173 532-534 IN denotes On
T4175 535-541 JJ denotes normal
T4177 542-546 NN denotes chow
T4176 547-551 NN denotes diet
T4178 551-553 , denotes ,
T4179 553-556 DT denotes the
T4181 557-567 JJ denotes transgenic
T4180 568-572 NNS denotes mice
T4182 573-576 CC denotes and
T4183 577-584 NN denotes control
T4184 585-596 NNS denotes littermates
T4185 597-601 VBN denotes used
T4186 602-606 RB denotes here
T4174 607-610 VBD denotes had
T4187 611-618 JJ denotes similar
T4189 619-623 NN denotes body
T4188 624-631 NNS denotes weights
T4190 631-632 . denotes .
T4191 632-695 sentence denotes PPARδ-null mice were previously generated (Barak et al. 2002).
T4192 633-638 NN denotes PPARδ
T4194 638-639 HYPH denotes -
T4193 639-643 JJ denotes null
T4195 644-648 NNS denotes mice
T4197 649-653 VBD denotes were
T4198 654-664 RB denotes previously
T4196 665-674 VBN denotes generated
T4199 675-676 -LRB- denotes (
T4200 676-681 NNP denotes Barak
T4201 682-684 FW denotes et
T4202 685-688 FW denotes al.
T4203 689-693 CD denotes 2002
T4204 693-694 -RRB- denotes )
T4205 694-695 . denotes .
T4206 695-950 sentence denotes Mice were fed either a standard chow with 4% (w/w) fat content (Harlan Teklad, Harlan, Indianapolis, Indiana, United States) or a high-fat diet containing 35% (w/w) fat content (product F3282, Bioserv, Frenchtown, New Jersey, United States) as indicated.
T4207 696-700 NNS denotes Mice
T4209 701-705 VBD denotes were
T4208 706-709 VBN denotes fed
T4210 710-716 CC denotes either
T4212 717-718 DT denotes a
T4213 719-727 JJ denotes standard
T4211 728-732 NN denotes chow
T4214 733-737 IN denotes with
T4215 738-739 CD denotes 4
T4216 739-740 NN denotes %
T4218 741-742 -LRB- denotes (
T4219 742-743 NN denotes w
T4220 743-744 SYM denotes /
T4221 744-745 NN denotes w
T4222 745-746 -RRB- denotes )
T4223 747-750 NN denotes fat
T4217 751-758 NN denotes content
T4224 759-760 -LRB- denotes (
T4226 760-766 NNP denotes Harlan
T4225 767-773 NNP denotes Teklad
T4227 773-775 , denotes ,
T4228 775-781 NNP denotes Harlan
T4229 781-783 , denotes ,
T4230 783-795 NNP denotes Indianapolis
T4231 795-797 , denotes ,
T4232 797-804 NNP denotes Indiana
T4233 804-806 , denotes ,
T4234 806-812 NNP denotes United
T4235 813-819 NNP denotes States
T4236 819-820 -RRB- denotes )
T4237 821-823 CC denotes or
T4238 824-825 DT denotes a
T4240 826-830 JJ denotes high
T4242 830-831 HYPH denotes -
T4241 831-834 NN denotes fat
T4239 835-839 NN denotes diet
T4243 840-850 VBG denotes containing
T4244 851-853 CD denotes 35
T4245 853-854 NN denotes %
T4247 855-856 -LRB- denotes (
T4248 856-857 NN denotes w
T4249 857-858 SYM denotes /
T4250 858-859 NN denotes w
T4251 859-860 -RRB- denotes )
T4252 861-864 NN denotes fat
T4246 865-872 NN denotes content
T4253 873-874 -LRB- denotes (
T4255 874-881 NN denotes product
T4254 882-887 NN denotes F3282
T4256 887-889 , denotes ,
T4257 889-896 NNP denotes Bioserv
T4258 896-898 , denotes ,
T4259 898-908 NNP denotes Frenchtown
T4260 908-910 , denotes ,
T4261 910-913 NNP denotes New
T4262 914-920 NNP denotes Jersey
T4263 920-922 , denotes ,
T4264 922-928 NNP denotes United
T4265 929-935 NNP denotes States
T4266 935-936 -RRB- denotes )
T4267 937-939 IN denotes as
T4268 940-949 VBN denotes indicated
T4269 949-950 . denotes .
T4270 950-1075 sentence denotes For ligand experiments, we synthesized the GW501516 compound and mice were orally gavaged daily (10 mg/kg or vehicle alone).
T4271 951-954 IN denotes For
T4273 955-961 NN denotes ligand
T4274 962-973 NNS denotes experiments
T4275 973-975 , denotes ,
T4276 975-977 PRP denotes we
T4272 978-989 VBD denotes synthesized
T4277 990-993 DT denotes the
T4279 994-1002 NN denotes GW501516
T4278 1003-1011 NN denotes compound
T4280 1012-1015 CC denotes and
T4281 1016-1020 NNS denotes mice
T4283 1021-1025 VBD denotes were
T4284 1026-1032 RB denotes orally
T4282 1033-1040 VBN denotes gavaged
T4285 1041-1046 RB denotes daily
T4286 1047-1048 -LRB- denotes (
T4288 1048-1050 CD denotes 10
T4287 1051-1053 NNS denotes mg
T4289 1053-1054 SYM denotes /
T4290 1054-1056 NN denotes kg
T4291 1057-1059 CC denotes or
T4292 1060-1067 NN denotes vehicle
T4293 1068-1073 RB denotes alone
T4294 1073-1074 -RRB- denotes )
T4295 1074-1075 . denotes .
R2917 T4059 T4058 punct .,Animals
R2918 T4061 T4062 det The,domain
R2919 T4062 T4064 nsubjpass domain,fused
R2920 T4063 T4062 compound transactivation,domain
R2921 T4065 T4066 punct (,residues
R2922 T4066 T4062 parataxis residues,domain
R2923 T4067 T4066 nummod 78,residues
R2924 T4068 T4069 compound amino,acid
R2925 T4069 T4066 compound acid,residues
R2926 T4070 T4066 punct ", ",residues
R2927 T4071 T4066 acl corresponding,residues
R2928 T4072 T4071 prep to,corresponding
R2929 T4073 T4074 nmod residues,413
R2930 T4074 T4072 pobj 413,to
R2931 T4075 T4076 punct –,490
R2932 T4076 T4074 prep 490,413
R2933 T4077 T4066 punct ),residues
R2934 T4078 T4062 prep of,domain
R2935 T4079 T4078 pobj VP16,of
R2936 T4080 T4064 auxpass was,fused
R2937 T4081 T4064 prep in,fused
R2938 T4082 T4081 pobj frame,in
R2939 T4083 T4064 prep with,fused
R2940 T4084 T4085 det the,terminus
R2941 T4085 T4083 pobj terminus,with
R2942 T4086 T4085 compound N,terminus
R2943 T4087 T4085 punct -,terminus
R2944 T4088 T4085 prep of,terminus
R2945 T4089 T4090 compound mouse,PPARδ
R2946 T4090 T4088 pobj PPARδ,of
R2947 T4091 T4064 punct .,fused
R2948 T4093 T4094 det The,cDNA
R2949 T4094 T4099 nsubjpass cDNA,placed
R2950 T4095 T4096 compound VP16,PPARδ
R2951 T4096 T4094 compound PPARδ,cDNA
R2952 T4097 T4096 punct -,PPARδ
R2953 T4098 T4094 compound fusion,cDNA
R2954 T4100 T4099 auxpass was,placed
R2955 T4101 T4099 advmod downstream,placed
R2956 T4102 T4101 prep of,downstream
R2957 T4103 T4104 det the,promoter
R2958 T4104 T4102 pobj promoter,of
R2959 T4105 T4104 amod human,promoter
R2960 T4106 T4107 npadvmod α,skeletal
R2961 T4107 T4104 amod skeletal,promoter
R2962 T4108 T4107 punct -,skeletal
R2963 T4109 T4104 compound actin,promoter
R2964 T4110 T4111 punct (,Brennan
R2965 T4111 T4104 meta Brennan,promoter
R2966 T4112 T4111 cc and,Brennan
R2967 T4135 T4133 cc and,purified
R2968 T4136 T4133 conj injected,purified
R2969 T4137 T4136 prep into,injected
R2970 T4138 T4139 nmod C57BL,6J
R2971 T4139 T4141 nmod 6J,zygotes
R2972 T4140 T4139 punct /,6J
R2973 T4141 T4137 pobj zygotes,into
R2974 T4142 T4139 punct ×,6J
R2975 T4143 T4139 appos CBA,6J
R2976 T4144 T4141 compound F1,zygotes
R2977 T4145 T4133 punct .,purified
R2978 T4147 T4148 amod Transgenic,mice
R2979 T4148 T4149 nsubjpass mice,backcrossed
R2980 T4150 T4149 auxpass were,backcrossed
R2981 T4151 T4149 prep with,backcrossed
R2982 T4152 T4153 compound C57BL,6J
R2983 T4153 T4151 pobj 6J,with
R2984 T4154 T4153 punct /,6J
R2985 T4155 T4149 prep for,backcrossed
R2986 T4156 T4157 nummod two,generations
R2987 T4157 T4155 pobj generations,for
R2988 T4158 T4149 punct .,backcrossed
R2989 T4160 T4161 amod Wild,type
R2990 T4161 T4163 compound type,littermates
R2991 T4162 T4161 punct -,type
R2992 T4163 T4164 nsubjpass littermates,used
R2993 T4165 T4164 auxpass were,used
R2994 T4166 T4164 prep as,used
R2995 T4167 T4166 pobj controls,as
R2996 T4168 T4164 prep throughout,used
R2997 T4169 T4170 det the,study
R2998 T4170 T4168 pobj study,throughout
R2999 T4171 T4164 punct .,used
R3000 T4173 T4174 prep On,had
R3001 T4175 T4176 amod normal,diet
R3002 T4176 T4173 pobj diet,On
R3003 T4177 T4176 compound chow,diet
R3004 T4178 T4174 punct ", ",had
R3005 T4179 T4180 det the,mice
R3006 T4180 T4174 nsubj mice,had
R3007 T4181 T4180 amod transgenic,mice
R3008 T4182 T4180 cc and,mice
R3009 T4183 T4184 compound control,littermates
R3010 T4184 T4180 conj littermates,mice
R3011 T4185 T4180 acl used,mice
R3012 T4186 T4185 advmod here,used
R3013 T4187 T4188 amod similar,weights
R3014 T4188 T4174 dobj weights,had
R3015 T4189 T4188 compound body,weights
R3016 T4190 T4174 punct .,had
R3017 T4192 T4193 npadvmod PPARδ,null
R3018 T4193 T4195 amod null,mice
R3019 T4194 T4193 punct -,null
R3020 T4195 T4196 nsubjpass mice,generated
R3021 T4197 T4196 auxpass were,generated
R3022 T4198 T4196 advmod previously,generated
R3023 T4199 T4200 punct (,Barak
R3024 T4200 T4196 meta Barak,generated
R3025 T4201 T4200 nmod et,Barak
R3026 T4202 T4200 nmod al.,Barak
R3027 T4203 T4200 nummod 2002,Barak
R3028 T4204 T4200 punct ),Barak
R3029 T4205 T4196 punct .,generated
R3030 T4207 T4208 nsubjpass Mice,fed
R3031 T4209 T4208 auxpass were,fed
R3032 T4210 T4211 preconj either,chow
R3033 T4211 T4208 dobj chow,fed
R3034 T4212 T4211 det a,chow
R3035 T4213 T4211 amod standard,chow
R3036 T4214 T4211 prep with,chow
R3037 T4215 T4216 nummod 4,%
R3038 T4216 T4217 nmod %,content
R3039 T4217 T4214 pobj content,with
R3040 T4218 T4219 punct (,w
R3041 T4219 T4217 parataxis w,content
R3042 T4220 T4221 punct /,w
R3043 T4221 T4219 prep w,w
R3044 T4222 T4219 punct ),w
R3045 T4223 T4217 compound fat,content
R3046 T4224 T4225 punct (,Teklad
R3047 T4225 T4211 parataxis Teklad,chow
R3048 T4226 T4225 compound Harlan,Teklad
R3049 T4227 T4225 punct ", ",Teklad
R3050 T4228 T4225 npadvmod Harlan,Teklad
R3051 T4229 T4225 punct ", ",Teklad
R3052 T4230 T4225 npadvmod Indianapolis,Teklad
R3053 T4231 T4225 punct ", ",Teklad
R3054 T4232 T4225 npadvmod Indiana,Teklad
R3055 T4233 T4225 punct ", ",Teklad
R3056 T4234 T4235 compound United,States
R3057 T4235 T4225 npadvmod States,Teklad
R3058 T4236 T4225 punct ),Teklad
R3059 T4237 T4211 cc or,chow
R3060 T4238 T4239 det a,diet
R3061 T4239 T4211 conj diet,chow
R3062 T4240 T4241 amod high,fat
R3063 T4241 T4239 compound fat,diet
R3064 T4242 T4241 punct -,fat
R3065 T4243 T4239 acl containing,diet
R3066 T4244 T4245 nummod 35,%
R3067 T4245 T4246 nmod %,content
R3068 T4246 T4243 dobj content,containing
R3069 T4247 T4248 punct (,w
R3070 T4248 T4246 parataxis w,content
R3071 T4249 T4250 punct /,w
R3072 T4250 T4248 prep w,w
R3073 T4251 T4248 punct ),w
R3074 T4252 T4246 compound fat,content
R3075 T4253 T4254 punct (,F3282
R3076 T4254 T4239 parataxis F3282,diet
R3077 T4255 T4254 compound product,F3282
R3078 T4256 T4254 punct ", ",F3282
R3079 T4257 T4254 npadvmod Bioserv,F3282
R3080 T4258 T4254 punct ", ",F3282
R3081 T4259 T4254 npadvmod Frenchtown,F3282
R3082 T4260 T4254 punct ", ",F3282
R3083 T4261 T4262 compound New,Jersey
R3084 T4262 T4254 npadvmod Jersey,F3282
R3085 T4263 T4254 punct ", ",F3282
R3086 T4264 T4265 compound United,States
R3087 T4265 T4254 npadvmod States,F3282
R3088 T4266 T4254 punct ),F3282
R3089 T4267 T4268 mark as,indicated
R3090 T4268 T4208 advcl indicated,fed
R3091 T4269 T4208 punct .,fed
R3092 T4271 T4272 prep For,synthesized
R3093 T4273 T4274 compound ligand,experiments
R3094 T4274 T4271 pobj experiments,For
R3095 T4275 T4272 punct ", ",synthesized
R3096 T4276 T4272 nsubj we,synthesized
R3097 T4277 T4278 det the,compound
R3098 T4278 T4272 dobj compound,synthesized
R3099 T4279 T4278 compound GW501516,compound
R3100 T4280 T4272 cc and,synthesized
R3101 T4281 T4282 nsubjpass mice,gavaged
R3102 T4282 T4272 conj gavaged,synthesized
R3103 T4283 T4282 auxpass were,gavaged
R3104 T4284 T4282 advmod orally,gavaged
R3105 T4285 T4282 advmod daily,gavaged
R3106 T4286 T4287 punct (,mg
R3107 T4287 T4282 parataxis mg,gavaged
R3108 T4288 T4287 nummod 10,mg
R3109 T4289 T4290 punct /,kg
R3110 T4290 T4287 prep kg,mg
R3111 T4291 T4287 cc or,mg
R3112 T4292 T4287 conj vehicle,mg
R3113 T4293 T4292 advmod alone,vehicle
R3114 T4294 T4287 punct ),mg
R3115 T4295 T4282 punct .,gavaged
R3116 T4113 T4111 conj Hardeman,Brennan
R3117 T4114 T4113 nummod 1993,Hardeman
R3118 T4115 T4113 punct ),Hardeman
R3119 T4116 T4101 punct ", ",downstream
R3120 T4117 T4101 cc and,downstream
R3121 T4118 T4101 conj upstream,downstream
R3122 T4119 T4118 prep of,upstream
R3123 T4120 T4121 det the,sequence
R3124 T4121 T4119 pobj sequence,of
R3125 T4122 T4123 nmod SV40,intron
R3126 T4123 T4121 nmod intron,sequence
R3127 T4124 T4123 punct /,intron
R3128 T4125 T4126 nmod poly,A
R3129 T4126 T4123 appos A,intron
R3130 T4127 T4126 punct (,A
R3131 T4128 T4126 punct ),A
R3132 T4129 T4099 punct .,placed
R3133 T4131 T4132 det The,transgene
R3134 T4132 T4133 nsubjpass transgene,purified
R3135 T4134 T4133 auxpass was,purified