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PMC:509410 / 20029-21169 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T3785 0-8 JJ denotes Skeletal
T3786 9-15 NN denotes muscle
T3787 16-18 VBZ denotes is
T3788 19-20 DT denotes a
T3790 21-26 JJ denotes major
T3789 27-31 NN denotes site
T3791 32-34 TO denotes to
T3792 35-43 VB denotes regulate
T3793 44-49 JJ denotes whole
T3795 49-50 HYPH denotes -
T3794 50-54 NN denotes body
T3797 55-60 JJ denotes fatty
T3799 60-61 HYPH denotes -
T3798 61-65 NN denotes acid
T3800 66-69 CC denotes and
T3801 70-77 NN denotes glucose
T3796 78-88 NN denotes metabolism
T3802 88-89 . denotes .
T3803 89-206 sentence denotes We show that mice with increased oxidative fibers are resistant to high-fat-induced obesity and glucose intolerance.
T3804 90-92 PRP denotes We
T3805 93-97 VBP denotes show
T3806 98-102 IN denotes that
T3808 103-107 NNS denotes mice
T3809 108-112 IN denotes with
T3810 113-122 VBN denotes increased
T3812 123-132 JJ denotes oxidative
T3811 133-139 NNS denotes fibers
T3807 140-143 VBP denotes are
T3813 144-153 JJ denotes resistant
T3814 154-156 IN denotes to
T3815 157-161 JJ denotes high
T3817 161-162 HYPH denotes -
T3816 162-165 NN denotes fat
T3819 165-166 HYPH denotes -
T3818 166-173 VBN denotes induced
T3820 174-181 NN denotes obesity
T3821 182-185 CC denotes and
T3822 186-193 NN denotes glucose
T3823 194-205 NN denotes intolerance
T3824 205-206 . denotes .
T3825 206-324 sentence denotes Moreover, ligand studies provide compelling evidence that activation of endogenous PPARδ can produce similar effects.
T3826 207-215 RB denotes Moreover
T3828 215-217 , denotes ,
T3829 217-223 NN denotes ligand
T3830 224-231 NNS denotes studies
T3827 232-239 VBP denotes provide
T3831 240-250 JJ denotes compelling
T3832 251-259 NN denotes evidence
T3833 260-264 IN denotes that
T3835 265-275 NN denotes activation
T3836 276-278 IN denotes of
T3837 279-289 JJ denotes endogenous
T3838 290-295 NN denotes PPARδ
T3839 296-299 MD denotes can
T3834 300-307 VB denotes produce
T3840 308-315 JJ denotes similar
T3841 316-323 NNS denotes effects
T3842 323-324 . denotes .
T3843 324-409 sentence denotes Might PPARδ have any beneficial effects on glucose metabolism in the lean condition?
T3844 325-330 MD denotes Might
T3846 331-336 NN denotes PPARδ
T3845 337-341 VB denotes have
T3847 342-345 DT denotes any
T3849 346-356 JJ denotes beneficial
T3848 357-364 NNS denotes effects
T3850 365-367 IN denotes on
T3851 368-375 NN denotes glucose
T3852 376-386 NN denotes metabolism
T3853 387-389 IN denotes in
T3854 390-393 DT denotes the
T3856 394-398 JJ denotes lean
T3855 399-408 NN denotes condition
T3857 408-409 . denotes ?
T3858 409-610 sentence denotes This has not been explored; however, insulin resistance in the elderly is confined mostly to skeletal muscle and may be due to reduction of mitochondrial number and/or function (Petersen et al. 2003).
T3859 410-414 DT denotes This
T3861 415-418 VBZ denotes has
T3862 419-422 RB denotes not
T3863 423-427 VBN denotes been
T3860 428-436 VBN denotes explored
T3865 436-437 : denotes ;
T3866 438-445 RB denotes however
T3867 445-447 , denotes ,
T3868 447-454 NN denotes insulin
T3869 455-465 NN denotes resistance
T3870 466-468 IN denotes in
T3871 469-472 DT denotes the
T3872 473-480 JJ denotes elderly
T3873 481-483 VBZ denotes is
T3864 484-492 VBN denotes confined
T3874 493-499 RB denotes mostly
T3875 500-502 IN denotes to
T3876 503-511 JJ denotes skeletal
T3877 512-518 NN denotes muscle
T3878 519-522 CC denotes and
T3879 523-526 MD denotes may
T3880 527-529 VB denotes be
T3881 530-533 IN denotes due
T3882 534-536 IN denotes to
T3883 537-546 NN denotes reduction
T3884 547-549 IN denotes of
T3885 550-563 JJ denotes mitochondrial
T3886 564-570 NN denotes number
T3887 571-574 CC denotes and
T3888 574-575 HYPH denotes /
T3889 575-577 CC denotes or
T3890 578-586 NN denotes function
T3891 587-588 -LRB- denotes (
T3892 588-596 NNP denotes Petersen
T3893 597-599 FW denotes et
T3894 600-603 FW denotes al.
T3895 604-608 CD denotes 2003
T3896 608-609 -RRB- denotes )
T3897 609-610 . denotes .
T3898 610-786 sentence denotes The ability of PPARδ to stimulate mitochondrial biogenesis and oxidative function suggests that PPARδ could be important for control of insulin resistance during normal aging.
T3899 611-614 DT denotes The
T3900 615-622 NN denotes ability
T3902 623-625 IN denotes of
T3903 626-631 NN denotes PPARδ
T3904 632-634 TO denotes to
T3905 635-644 VB denotes stimulate
T3906 645-658 JJ denotes mitochondrial
T3907 659-669 NN denotes biogenesis
T3908 670-673 CC denotes and
T3909 674-683 JJ denotes oxidative
T3910 684-692 NN denotes function
T3901 693-701 VBZ denotes suggests
T3911 702-706 IN denotes that
T3913 707-712 NN denotes PPARδ
T3914 713-718 MD denotes could
T3912 719-721 VB denotes be
T3915 722-731 JJ denotes important
T3916 732-735 IN denotes for
T3917 736-743 NN denotes control
T3918 744-746 IN denotes of
T3919 747-754 NN denotes insulin
T3920 755-765 NN denotes resistance
T3921 766-772 IN denotes during
T3922 773-779 JJ denotes normal
T3923 780-785 NN denotes aging
T3924 785-786 . denotes .
T3925 786-1000 sentence denotes Together, these data indicate that PPARδ and its ligands comprise a key molecular switch to regulate muscle fiber specification, obesity resistance, insulin sensitivity, and, most surprisingly, physical endurance.
T3926 787-795 RB denotes Together
T3928 795-797 , denotes ,
T3929 797-802 DT denotes these
T3930 803-807 NNS denotes data
T3927 808-816 VBP denotes indicate
T3931 817-821 IN denotes that
T3933 822-827 NN denotes PPARδ
T3934 828-831 CC denotes and
T3935 832-835 PRP$ denotes its
T3936 836-843 NNS denotes ligands
T3932 844-852 VBP denotes comprise
T3937 853-854 DT denotes a
T3939 855-858 JJ denotes key
T3940 859-868 JJ denotes molecular
T3938 869-875 NN denotes switch
T3941 876-878 TO denotes to
T3942 879-887 VB denotes regulate
T3943 888-894 NN denotes muscle
T3944 895-900 NN denotes fiber
T3945 901-914 NN denotes specification
T3946 914-916 , denotes ,
T3947 916-923 NN denotes obesity
T3948 924-934 NN denotes resistance
T3949 934-936 , denotes ,
T3950 936-943 NN denotes insulin
T3951 944-955 NN denotes sensitivity
T3952 955-957 , denotes ,
T3953 957-960 CC denotes and
T3954 960-962 , denotes ,
T3955 962-966 RBS denotes most
T3956 967-979 RB denotes surprisingly
T3958 979-981 , denotes ,
T3959 981-989 JJ denotes physical
T3957 990-999 NN denotes endurance
T3960 999-1000 . denotes .
T3961 1000-1140 sentence denotes This work demonstrates that complex physiologic properties such as fatigue, endurance, and running capacity can be genetically manipulated.
T3962 1001-1005 DT denotes This
T3963 1006-1010 NN denotes work
T3964 1011-1023 VBZ denotes demonstrates
T3965 1024-1028 IN denotes that
T3967 1029-1036 JJ denotes complex
T3969 1037-1048 JJ denotes physiologic
T3968 1049-1059 NNS denotes properties
T3970 1060-1064 JJ denotes such
T3971 1065-1067 IN denotes as
T3972 1068-1075 NN denotes fatigue
T3973 1075-1077 , denotes ,
T3974 1077-1086 NN denotes endurance
T3975 1086-1088 , denotes ,
T3976 1088-1091 CC denotes and
T3977 1092-1099 NN denotes running
T3978 1100-1108 NN denotes capacity
T3979 1109-1112 MD denotes can
T3980 1113-1115 VB denotes be
T3981 1116-1127 RB denotes genetically
T3966 1128-1139 VBN denotes manipulated
T3982 1139-1140 . denotes .
R2734 T3785 T3786 amod Skeletal,muscle
R2735 T3786 T3787 nsubj muscle,is
R2736 T3788 T3789 det a,site
R2737 T3789 T3787 attr site,is
R2738 T3790 T3789 amod major,site
R2739 T3791 T3792 aux to,regulate
R2740 T3792 T3789 advcl regulate,site
R2741 T3793 T3794 amod whole,body
R2742 T3794 T3796 nmod body,metabolism
R2743 T3795 T3794 punct -,body
R2744 T3796 T3792 dobj metabolism,regulate
R2745 T3797 T3798 amod fatty,acid
R2746 T3798 T3796 nmod acid,metabolism
R2747 T3799 T3798 punct -,acid
R2748 T3800 T3798 cc and,acid
R2749 T3801 T3798 conj glucose,acid
R2750 T3802 T3787 punct .,is
R2751 T3804 T3805 nsubj We,show
R2752 T3806 T3807 mark that,are
R2753 T3807 T3805 ccomp are,show
R2754 T3808 T3807 nsubj mice,are
R2755 T3809 T3808 prep with,mice
R2756 T3810 T3811 amod increased,fibers
R2757 T3811 T3809 pobj fibers,with
R2758 T3812 T3811 amod oxidative,fibers
R2759 T3813 T3807 acomp resistant,are
R2760 T3814 T3813 prep to,resistant
R2761 T3815 T3816 amod high,fat
R2762 T3816 T3818 npadvmod fat,induced
R2763 T3817 T3816 punct -,fat
R2764 T3818 T3820 amod induced,obesity
R2765 T3819 T3818 punct -,induced
R2766 T3820 T3814 pobj obesity,to
R2767 T3821 T3820 cc and,obesity
R2768 T3822 T3823 compound glucose,intolerance
R2769 T3823 T3820 conj intolerance,obesity
R2770 T3824 T3805 punct .,show
R2771 T3826 T3827 advmod Moreover,provide
R2772 T3828 T3827 punct ", ",provide
R2773 T3829 T3830 compound ligand,studies
R2774 T3830 T3827 nsubj studies,provide
R2775 T3831 T3832 amod compelling,evidence
R2776 T3832 T3827 dobj evidence,provide
R2777 T3833 T3834 mark that,produce
R2778 T3834 T3832 acl produce,evidence
R2779 T3835 T3834 nsubj activation,produce
R2780 T3836 T3835 prep of,activation
R2781 T3837 T3838 amod endogenous,PPARδ
R2782 T3838 T3836 pobj PPARδ,of
R2783 T3839 T3834 aux can,produce
R2784 T3840 T3841 amod similar,effects
R2785 T3841 T3834 dobj effects,produce
R2786 T3842 T3827 punct .,provide
R2787 T3844 T3845 aux Might,have
R2788 T3846 T3845 nsubj PPARδ,have
R2789 T3847 T3848 det any,effects
R2790 T3848 T3845 dobj effects,have
R2791 T3849 T3848 amod beneficial,effects
R2792 T3850 T3848 prep on,effects
R2793 T3851 T3852 compound glucose,metabolism
R2794 T3852 T3850 pobj metabolism,on
R2795 T3853 T3845 prep in,have
R2796 T3854 T3855 det the,condition
R2797 T3855 T3853 pobj condition,in
R2798 T3856 T3855 amod lean,condition
R2799 T3857 T3845 punct ?,have
R2800 T3859 T3860 nsubjpass This,explored
R2801 T3860 T3864 ccomp explored,confined
R2802 T3861 T3860 aux has,explored
R2803 T3862 T3860 neg not,explored
R2804 T3863 T3860 auxpass been,explored
R2805 T3865 T3864 punct ;,confined
R2806 T3866 T3864 advmod however,confined
R2807 T3867 T3864 punct ", ",confined
R2808 T3868 T3869 compound insulin,resistance
R2809 T3869 T3864 nsubjpass resistance,confined
R2810 T3870 T3869 prep in,resistance
R2811 T3871 T3872 det the,elderly
R2812 T3872 T3870 pobj elderly,in
R2813 T3873 T3864 auxpass is,confined
R2814 T3874 T3875 advmod mostly,to
R2815 T3875 T3864 prep to,confined
R2816 T3876 T3877 amod skeletal,muscle
R2817 T3877 T3875 pobj muscle,to
R2818 T3878 T3864 cc and,confined
R2819 T3879 T3880 aux may,be
R2820 T3880 T3864 conj be,confined
R2821 T3881 T3880 prep due,be
R2822 T3882 T3881 pcomp to,due
R2823 T3883 T3881 pobj reduction,due
R2824 T3884 T3883 prep of,reduction
R2825 T3885 T3886 amod mitochondrial,number
R2826 T3886 T3884 pobj number,of
R2827 T3887 T3886 cc and,number
R2828 T3888 T3887 punct /,and
R2829 T3889 T3887 cc or,and
R2830 T3890 T3886 conj function,number
R2831 T3891 T3892 punct (,Petersen
R2832 T3892 T3880 meta Petersen,be
R2833 T3893 T3892 nmod et,Petersen
R2834 T3894 T3892 nmod al.,Petersen
R2835 T3895 T3892 nummod 2003,Petersen
R2836 T3896 T3892 punct ),Petersen
R2837 T3897 T3864 punct .,confined
R2838 T3899 T3900 det The,ability
R2839 T3900 T3901 nsubj ability,suggests
R2840 T3902 T3900 prep of,ability
R2841 T3903 T3902 pobj PPARδ,of
R2842 T3904 T3905 aux to,stimulate
R2843 T3905 T3900 acl stimulate,ability
R2844 T3906 T3907 amod mitochondrial,biogenesis
R2845 T3907 T3905 dobj biogenesis,stimulate
R2846 T3908 T3907 cc and,biogenesis
R2847 T3909 T3910 amod oxidative,function
R2848 T3910 T3907 conj function,biogenesis
R2849 T3911 T3912 mark that,be
R2850 T3912 T3901 ccomp be,suggests
R2851 T3913 T3912 nsubj PPARδ,be
R2852 T3914 T3912 aux could,be
R2853 T3915 T3912 acomp important,be
R2854 T3916 T3912 prep for,be
R2855 T3917 T3916 pobj control,for
R2856 T3918 T3917 prep of,control
R2857 T3919 T3920 compound insulin,resistance
R2858 T3920 T3918 pobj resistance,of
R2859 T3921 T3912 prep during,be
R2860 T3922 T3923 amod normal,aging
R2861 T3923 T3921 pobj aging,during
R2862 T3924 T3901 punct .,suggests
R2863 T3926 T3927 advmod Together,indicate
R2864 T3928 T3927 punct ", ",indicate
R2865 T3929 T3930 det these,data
R2866 T3930 T3927 nsubj data,indicate
R2867 T3931 T3932 mark that,comprise
R2868 T3932 T3927 ccomp comprise,indicate
R2869 T3933 T3932 nsubj PPARδ,comprise
R2870 T3934 T3933 cc and,PPARδ
R2871 T3935 T3936 poss its,ligands
R2872 T3936 T3933 conj ligands,PPARδ
R2873 T3937 T3938 det a,switch
R2874 T3938 T3932 dobj switch,comprise
R2875 T3939 T3938 amod key,switch
R2876 T3940 T3938 amod molecular,switch
R2877 T3941 T3942 aux to,regulate
R2878 T3942 T3938 advcl regulate,switch
R2879 T3943 T3944 compound muscle,fiber
R2880 T3944 T3945 compound fiber,specification
R2881 T3945 T3942 dobj specification,regulate
R2882 T3946 T3945 punct ", ",specification
R2883 T3947 T3948 compound obesity,resistance
R2884 T3948 T3945 conj resistance,specification
R2885 T3949 T3948 punct ", ",resistance
R2886 T3950 T3951 compound insulin,sensitivity
R2887 T3951 T3948 conj sensitivity,resistance
R2888 T3952 T3951 punct ", ",sensitivity
R2889 T3953 T3951 cc and,sensitivity
R2890 T3954 T3951 punct ", ",sensitivity
R2891 T3955 T3956 advmod most,surprisingly
R2892 T3956 T3957 advmod surprisingly,endurance
R2893 T3957 T3951 conj endurance,sensitivity
R2894 T3958 T3957 punct ", ",endurance
R2895 T3959 T3957 amod physical,endurance
R2896 T3960 T3927 punct .,indicate
R2897 T3962 T3963 det This,work
R2898 T3963 T3964 nsubj work,demonstrates
R2899 T3965 T3966 mark that,manipulated
R2900 T3966 T3964 ccomp manipulated,demonstrates
R2901 T3967 T3968 amod complex,properties
R2902 T3968 T3966 nsubjpass properties,manipulated
R2903 T3969 T3968 amod physiologic,properties
R2904 T3970 T3971 amod such,as
R2905 T3971 T3968 prep as,properties
R2906 T3972 T3971 pobj fatigue,as
R2907 T3973 T3972 punct ", ",fatigue
R2908 T3974 T3972 conj endurance,fatigue
R2909 T3975 T3974 punct ", ",endurance
R2910 T3976 T3974 cc and,endurance
R2911 T3977 T3978 compound running,capacity
R2912 T3978 T3974 conj capacity,endurance
R2913 T3979 T3966 aux can,manipulated
R2914 T3980 T3966 auxpass be,manipulated
R2915 T3981 T3966 advmod genetically,manipulated
R2916 T3982 T3964 punct .,demonstrates