craft-sa-dev Home  

PMC:509410 / 16698-21169 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T3182 11-14 PRP$ denotes Our
T3183 15-19 NNS denotes data
T3184 20-26 VBP denotes reveal
T3185 27-31 IN denotes that
T3187 32-33 DT denotes a
T3189 34-39 NN denotes PPARδ
T3191 39-40 HYPH denotes -
T3190 40-48 VBN denotes mediated
T3192 49-64 JJ denotes transcriptional
T3188 65-72 NN denotes pathway
T3193 73-76 MD denotes can
T3186 77-85 VB denotes regulate
T3194 86-92 NN denotes muscle
T3195 93-98 NN denotes fiber
T3196 99-112 NN denotes specification
T3197 112-114 , denotes ,
T3198 114-122 VBG denotes enabling
T3199 123-126 DT denotes the
T3200 127-137 NN denotes generation
T3201 138-140 IN denotes of
T3202 141-142 DT denotes a
T3203 143-149 NN denotes strain
T3204 150-152 IN denotes of
T3205 153-157 NNS denotes mice
T3206 158-162 IN denotes with
T3207 163-164 DT denotes a
T3209 165-166 `` denotes “
T3210 166-170 JJ denotes long
T3212 170-171 HYPH denotes -
T3211 171-179 NN denotes distance
T3213 180-187 NN denotes running
T3214 187-188 '' denotes ”
T3208 189-198 NN denotes phenotype
T3215 198-199 . denotes .
T3216 199-483 sentence denotes We show that targeted expression of an activated form of PPARδ produces profound and coordinated increases in oxidation enzymes, mitochondrial biogenesis, and production of specialized type I fiber contractile proteins—the three hallmarks for muscle fiber type switching (Figure 6C).
T3217 200-202 PRP denotes We
T3218 203-207 VBP denotes show
T3219 208-212 IN denotes that
T3221 213-221 VBN denotes targeted
T3222 222-232 NN denotes expression
T3223 233-235 IN denotes of
T3224 236-238 DT denotes an
T3226 239-248 JJ denotes activated
T3225 249-253 NN denotes form
T3227 254-256 IN denotes of
T3228 257-262 NN denotes PPARδ
T3220 263-271 VBZ denotes produces
T3229 272-280 JJ denotes profound
T3231 281-284 CC denotes and
T3232 285-296 VBN denotes coordinated
T3230 297-306 NNS denotes increases
T3233 307-309 IN denotes in
T3234 310-319 NN denotes oxidation
T3235 320-327 NNS denotes enzymes
T3236 327-329 , denotes ,
T3237 329-342 JJ denotes mitochondrial
T3238 343-353 NN denotes biogenesis
T3239 353-355 , denotes ,
T3240 355-358 CC denotes and
T3241 359-369 NN denotes production
T3242 370-372 IN denotes of
T3243 373-384 VBN denotes specialized
T3245 385-389 NN denotes type
T3247 390-391 CD denotes I
T3246 392-397 NN denotes fiber
T3248 398-409 JJ denotes contractile
T3244 410-418 NN denotes proteins
T3249 418-419 : denotes —
T3250 419-422 DT denotes the
T3252 423-428 CD denotes three
T3251 429-438 NNS denotes hallmarks
T3253 439-442 IN denotes for
T3254 443-449 NN denotes muscle
T3255 450-455 NN denotes fiber
T3257 456-460 NN denotes type
T3256 461-470 NN denotes switching
T3258 471-472 -LRB- denotes (
T3259 472-478 NN denotes Figure
T3260 479-481 CD denotes 6C
T3261 481-482 -RRB- denotes )
T3262 482-483 . denotes .
T3263 483-741 sentence denotes While induction of muscle oxidation enzymes by PPARδ has been seen both in vivo and in vitro (Muoio et al. 2002; Dressel et al. 2003; Luquet et al. 2003; Tanaka et al. 2003; Wang et al. 2003), its effects shown here on muscle fiber switching are unexpected.
T3264 484-489 IN denotes While
T3266 490-499 NN denotes induction
T3267 500-502 IN denotes of
T3268 503-509 NN denotes muscle
T3270 510-519 NN denotes oxidation
T3269 520-527 NNS denotes enzymes
T3271 528-530 IN denotes by
T3272 531-536 NN denotes PPARδ
T3273 537-540 VBZ denotes has
T3274 541-545 VBN denotes been
T3265 546-550 VBN denotes seen
T3276 551-555 CC denotes both
T3278 556-558 FW denotes in
T3277 559-563 FW denotes vivo
T3279 564-567 CC denotes and
T3280 568-570 FW denotes in
T3281 571-576 FW denotes vitro
T3282 577-578 -LRB- denotes (
T3283 578-583 NNP denotes Muoio
T3284 584-586 FW denotes et
T3285 587-590 FW denotes al.
T3286 591-595 CD denotes 2002
T3287 595-596 : denotes ;
T3288 597-604 NNP denotes Dressel
T3289 605-607 FW denotes et
T3290 608-611 FW denotes al.
T3291 612-616 CD denotes 2003
T3292 616-617 : denotes ;
T3293 618-624 NNP denotes Luquet
T3294 625-627 FW denotes et
T3295 628-631 FW denotes al.
T3296 632-636 CD denotes 2003
T3297 636-637 : denotes ;
T3298 638-644 NNP denotes Tanaka
T3299 645-647 FW denotes et
T3300 648-651 FW denotes al.
T3301 652-656 CD denotes 2003
T3302 656-657 : denotes ;
T3303 658-662 NNP denotes Wang
T3304 663-665 FW denotes et
T3305 666-669 FW denotes al.
T3306 670-674 CD denotes 2003
T3307 674-675 -RRB- denotes )
T3308 675-677 , denotes ,
T3309 677-680 PRP$ denotes its
T3310 681-688 NNS denotes effects
T3311 689-694 VBN denotes shown
T3312 695-699 RB denotes here
T3313 700-702 IN denotes on
T3314 703-709 NN denotes muscle
T3315 710-715 NN denotes fiber
T3316 716-725 NN denotes switching
T3275 726-729 VBP denotes are
T3317 730-740 JJ denotes unexpected
T3318 740-741 . denotes .
T3319 741-930 sentence denotes These progressive changes in oxidative capacity in conjunction with eventual changes in type I muscle fiber lead to a dramatically improved exercise profile and protection against obesity.
T3320 742-747 DT denotes These
T3322 748-759 JJ denotes progressive
T3321 760-767 NNS denotes changes
T3324 768-770 IN denotes in
T3325 771-780 JJ denotes oxidative
T3326 781-789 NN denotes capacity
T3327 790-792 IN denotes in
T3328 793-804 NN denotes conjunction
T3329 805-809 IN denotes with
T3330 810-818 JJ denotes eventual
T3331 819-826 NNS denotes changes
T3332 827-829 IN denotes in
T3333 830-834 NN denotes type
T3335 835-836 CD denotes I
T3336 837-843 NN denotes muscle
T3334 844-849 NN denotes fiber
T3323 850-854 VBP denotes lead
T3337 855-857 IN denotes to
T3338 858-859 DT denotes a
T3340 860-872 RB denotes dramatically
T3341 873-881 VBN denotes improved
T3342 882-890 NN denotes exercise
T3339 891-898 NN denotes profile
T3343 899-902 CC denotes and
T3344 903-913 NN denotes protection
T3345 914-921 IN denotes against
T3346 922-929 NN denotes obesity
T3347 929-930 . denotes .
T3348 930-1185 sentence denotes This does not solely depend on achieving a directed muscle fiber type switch but also requires all the associated changes in neural innervation, motor neuron function, and peripheral metabolic adaptation to enable a new integrated physiological response.
T3349 931-935 DT denotes This
T3351 936-940 VBZ denotes does
T3352 941-944 RB denotes not
T3353 945-951 RB denotes solely
T3350 952-958 VB denotes depend
T3354 959-961 IN denotes on
T3355 962-971 VBG denotes achieving
T3356 972-973 DT denotes a
T3358 974-982 VBN denotes directed
T3359 983-989 NN denotes muscle
T3360 990-995 NN denotes fiber
T3361 996-1000 NN denotes type
T3357 1001-1007 NN denotes switch
T3362 1008-1011 CC denotes but
T3363 1012-1016 RB denotes also
T3364 1017-1025 VBZ denotes requires
T3365 1026-1029 PDT denotes all
T3367 1030-1033 DT denotes the
T3368 1034-1044 VBN denotes associated
T3366 1045-1052 NNS denotes changes
T3369 1053-1055 IN denotes in
T3370 1056-1062 JJ denotes neural
T3371 1063-1074 NN denotes innervation
T3372 1074-1076 , denotes ,
T3373 1076-1081 NN denotes motor
T3374 1082-1088 NN denotes neuron
T3375 1089-1097 NN denotes function
T3376 1097-1099 , denotes ,
T3377 1099-1102 CC denotes and
T3378 1103-1113 JJ denotes peripheral
T3380 1114-1123 JJ denotes metabolic
T3379 1124-1134 NN denotes adaptation
T3381 1135-1137 TO denotes to
T3382 1138-1144 VB denotes enable
T3383 1145-1146 DT denotes a
T3385 1147-1150 JJ denotes new
T3386 1151-1161 VBN denotes integrated
T3387 1162-1175 JJ denotes physiological
T3384 1176-1184 NN denotes response
T3388 1184-1185 . denotes .
T3389 1185-1324 sentence denotes Accordingly, activation of muscle PPARδ essentially recapitulates the effects of exercise training even in the absence of training itself.
T3390 1186-1197 RB denotes Accordingly
T3392 1197-1199 , denotes ,
T3393 1199-1209 NN denotes activation
T3394 1210-1212 IN denotes of
T3395 1213-1219 NN denotes muscle
T3396 1220-1225 NN denotes PPARδ
T3397 1226-1237 RB denotes essentially
T3391 1238-1251 VBZ denotes recapitulates
T3398 1252-1255 DT denotes the
T3399 1256-1263 NNS denotes effects
T3400 1264-1266 IN denotes of
T3401 1267-1275 NN denotes exercise
T3402 1276-1284 NN denotes training
T3403 1285-1289 RB denotes even
T3404 1290-1292 IN denotes in
T3405 1293-1296 DT denotes the
T3406 1297-1304 NN denotes absence
T3407 1305-1307 IN denotes of
T3408 1308-1316 VBG denotes training
T3409 1317-1323 PRP denotes itself
T3410 1323-1324 . denotes .
T3411 1324-1417 sentence denotes To our knowledge, this has not been directly described for any other transcriptional factor.
T3412 1325-1327 IN denotes To
T3414 1328-1331 PRP$ denotes our
T3415 1332-1341 NN denotes knowledge
T3416 1341-1343 , denotes ,
T3417 1343-1347 DT denotes this
T3418 1348-1351 VBZ denotes has
T3419 1352-1355 RB denotes not
T3420 1356-1360 VBN denotes been
T3421 1361-1369 RB denotes directly
T3413 1370-1379 VBN denotes described
T3422 1380-1383 IN denotes for
T3423 1384-1387 DT denotes any
T3425 1388-1393 JJ denotes other
T3426 1394-1409 JJ denotes transcriptional
T3424 1410-1416 NN denotes factor
T3427 1416-1417 . denotes .
T3428 1417-1735 sentence denotes The muscle phenotypes described here are remarkably similar to those of transgenic mice expressing either calcineurin, calmodulin-dependent kinase, or PGC-1α (Naya et al. 2000; Lin et al. 2002; Wu et al. 2002), indicating that PPARδ could be one of the hypothetical downstream transcription factors of these pathways.
T3429 1418-1421 DT denotes The
T3431 1422-1428 NN denotes muscle
T3430 1429-1439 NNS denotes phenotypes
T3433 1440-1449 VBN denotes described
T3434 1450-1454 RB denotes here
T3432 1455-1458 VBP denotes are
T3435 1459-1469 RB denotes remarkably
T3436 1470-1477 JJ denotes similar
T3437 1478-1480 IN denotes to
T3438 1481-1486 DT denotes those
T3439 1487-1489 IN denotes of
T3440 1490-1500 JJ denotes transgenic
T3441 1501-1505 NNS denotes mice
T3442 1506-1516 VBG denotes expressing
T3443 1517-1523 CC denotes either
T3444 1524-1535 NN denotes calcineurin
T3445 1535-1537 , denotes ,
T3446 1537-1547 NN denotes calmodulin
T3448 1547-1548 HYPH denotes -
T3447 1548-1557 JJ denotes dependent
T3449 1558-1564 NN denotes kinase
T3450 1564-1566 , denotes ,
T3451 1566-1568 CC denotes or
T3452 1569-1572 NN denotes PGC
T3453 1572-1573 HYPH denotes -
T3454 1573-1575 CD denotes 1α
T3455 1576-1577 -LRB- denotes (
T3456 1577-1581 NNP denotes Naya
T3457 1582-1584 FW denotes et
T3458 1585-1588 FW denotes al.
T3459 1589-1593 CD denotes 2000
T3460 1593-1594 : denotes ;
T3461 1595-1598 NNP denotes Lin
T3462 1599-1601 FW denotes et
T3463 1602-1605 FW denotes al.
T3464 1606-1610 CD denotes 2002
T3465 1610-1611 : denotes ;
T3466 1612-1614 NNP denotes Wu
T3467 1615-1617 FW denotes et
T3468 1618-1621 FW denotes al.
T3469 1622-1626 CD denotes 2002
T3470 1626-1627 -RRB- denotes )
T3471 1627-1629 , denotes ,
T3472 1629-1639 VBG denotes indicating
T3473 1640-1644 IN denotes that
T3475 1645-1650 NN denotes PPARδ
T3476 1651-1656 MD denotes could
T3474 1657-1659 VB denotes be
T3477 1660-1663 CD denotes one
T3478 1664-1666 IN denotes of
T3479 1667-1670 DT denotes the
T3481 1671-1683 JJ denotes hypothetical
T3482 1684-1694 JJ denotes downstream
T3483 1695-1708 NN denotes transcription
T3480 1709-1716 NNS denotes factors
T3484 1717-1719 IN denotes of
T3485 1720-1725 DT denotes these
T3486 1726-1734 NNS denotes pathways
T3487 1734-1735 . denotes .
T3488 1735-1894 sentence denotes It is important to note that, from our ligand and gain-of-function transgenic studies, PPARδ needs to be activated in order to direct the muscle fiber switch.
T3489 1736-1738 PRP denotes It
T3490 1739-1741 VBZ denotes is
T3491 1742-1751 JJ denotes important
T3492 1752-1754 TO denotes to
T3493 1755-1759 VB denotes note
T3494 1760-1764 IN denotes that
T3496 1764-1766 , denotes ,
T3497 1766-1770 IN denotes from
T3498 1771-1774 PRP$ denotes our
T3500 1775-1781 NN denotes ligand
T3501 1782-1785 CC denotes and
T3502 1786-1790 NN denotes gain
T3503 1790-1791 HYPH denotes -
T3504 1791-1793 IN denotes of
T3505 1793-1794 HYPH denotes -
T3506 1794-1802 NN denotes function
T3507 1803-1813 JJ denotes transgenic
T3499 1814-1821 NNS denotes studies
T3508 1821-1823 , denotes ,
T3509 1823-1828 NN denotes PPARδ
T3495 1829-1834 VBZ denotes needs
T3510 1835-1837 TO denotes to
T3512 1838-1840 VB denotes be
T3511 1841-1850 VBN denotes activated
T3513 1851-1853 IN denotes in
T3514 1854-1859 NN denotes order
T3515 1860-1862 TO denotes to
T3516 1863-1869 VB denotes direct
T3517 1870-1873 DT denotes the
T3519 1874-1880 NN denotes muscle
T3520 1881-1886 NN denotes fiber
T3518 1887-1893 NN denotes switch
T3521 1893-1894 . denotes .
T3522 1894-2128 sentence denotes Indeed, in a recent report by Luquet et al. (2003), simple overexpression of wild-type PPARδ in muscle was found not to be sufficient to promote a fiber switch or obesity resistance, although certain oxidation enzymes were increased.
T3523 1895-1901 RB denotes Indeed
T3525 1901-1903 , denotes ,
T3526 1903-1905 IN denotes in
T3527 1906-1907 DT denotes a
T3529 1908-1914 JJ denotes recent
T3528 1915-1921 NN denotes report
T3530 1922-1924 IN denotes by
T3531 1925-1931 NNP denotes Luquet
T3532 1932-1934 FW denotes et
T3533 1935-1938 FW denotes al.
T3534 1939-1940 -LRB- denotes (
T3535 1940-1944 CD denotes 2003
T3536 1944-1945 -RRB- denotes )
T3537 1945-1947 , denotes ,
T3538 1947-1953 JJ denotes simple
T3539 1954-1968 NN denotes overexpression
T3540 1969-1971 IN denotes of
T3541 1972-1976 JJ denotes wild
T3543 1976-1977 HYPH denotes -
T3542 1977-1981 NN denotes type
T3544 1982-1987 NN denotes PPARδ
T3545 1988-1990 IN denotes in
T3546 1991-1997 NN denotes muscle
T3547 1998-2001 VBD denotes was
T3524 2002-2007 VBN denotes found
T3548 2008-2011 RB denotes not
T3550 2012-2014 TO denotes to
T3549 2015-2017 VB denotes be
T3551 2018-2028 JJ denotes sufficient
T3552 2029-2031 TO denotes to
T3553 2032-2039 VB denotes promote
T3554 2040-2041 DT denotes a
T3556 2042-2047 NN denotes fiber
T3555 2048-2054 NN denotes switch
T3557 2055-2057 CC denotes or
T3558 2058-2065 NN denotes obesity
T3559 2066-2076 NN denotes resistance
T3560 2076-2078 , denotes ,
T3561 2078-2086 IN denotes although
T3563 2087-2094 JJ denotes certain
T3565 2095-2104 NN denotes oxidation
T3564 2105-2112 NNS denotes enzymes
T3566 2113-2117 VBD denotes were
T3562 2118-2127 VBN denotes increased
T3567 2127-2128 . denotes .
T3568 2128-2238 sentence denotes This supports the model in Figure 6C that the activating signal or ligand, but not the receptor, is limiting.
T3569 2129-2133 DT denotes This
T3570 2134-2142 VBZ denotes supports
T3571 2143-2146 DT denotes the
T3572 2147-2152 NN denotes model
T3573 2153-2155 IN denotes in
T3574 2156-2162 NN denotes Figure
T3575 2163-2165 CD denotes 6C
T3576 2166-2170 IN denotes that
T3578 2171-2174 DT denotes the
T3580 2175-2185 VBG denotes activating
T3579 2186-2192 NN denotes signal
T3581 2193-2195 CC denotes or
T3582 2196-2202 NN denotes ligand
T3583 2202-2204 , denotes ,
T3584 2204-2207 CC denotes but
T3585 2208-2211 RB denotes not
T3586 2212-2215 DT denotes the
T3587 2216-2224 NN denotes receptor
T3588 2224-2226 , denotes ,
T3577 2226-2228 VBZ denotes is
T3589 2229-2237 VBG denotes limiting
T3590 2237-2238 . denotes .
T3591 2238-2400 sentence denotes Thus, PPARδ activation, rather than merely an increase of PPARδ levels, is an essential element for fiber switching and its associated functional manifestations.
T3592 2239-2243 RB denotes Thus
T3594 2243-2245 , denotes ,
T3595 2245-2250 NN denotes PPARδ
T3596 2251-2261 NN denotes activation
T3597 2261-2263 , denotes ,
T3598 2263-2269 RB denotes rather
T3599 2270-2274 IN denotes than
T3600 2275-2281 RB denotes merely
T3602 2282-2284 DT denotes an
T3601 2285-2293 NN denotes increase
T3603 2294-2296 IN denotes of
T3604 2297-2302 NN denotes PPARδ
T3605 2303-2309 NNS denotes levels
T3606 2309-2311 , denotes ,
T3593 2311-2313 VBZ denotes is
T3607 2314-2316 DT denotes an
T3609 2317-2326 JJ denotes essential
T3608 2327-2334 NN denotes element
T3610 2335-2338 IN denotes for
T3611 2339-2344 NN denotes fiber
T3612 2345-2354 NN denotes switching
T3613 2355-2358 CC denotes and
T3614 2359-2362 PRP$ denotes its
T3616 2363-2373 VBN denotes associated
T3617 2374-2384 JJ denotes functional
T3615 2385-2399 NNS denotes manifestations
T3618 2399-2400 . denotes .
T3619 2400-2476 sentence denotes How might endogenous PPARδ become activated naturally by exercise training?
T3620 2401-2404 WRB denotes How
T3622 2405-2410 MD denotes might
T3623 2411-2421 JJ denotes endogenous
T3624 2422-2427 NN denotes PPARδ
T3621 2428-2434 VB denotes become
T3625 2435-2444 VBN denotes activated
T3626 2445-2454 RB denotes naturally
T3627 2455-2457 IN denotes by
T3628 2458-2466 NN denotes exercise
T3629 2467-2475 NN denotes training
T3630 2475-2476 . denotes ?
T3631 2476-2655 sentence denotes First, it is possible that exercise generates or increases endogenous ligands for PPARδ as tissues are undergoing substantial increases in fatty-acid internalization and burning.
T3632 2477-2482 RB denotes First
T3634 2482-2484 , denotes ,
T3635 2484-2486 PRP denotes it
T3633 2487-2489 VBZ denotes is
T3636 2490-2498 JJ denotes possible
T3637 2499-2503 IN denotes that
T3639 2504-2512 NN denotes exercise
T3638 2513-2522 VBZ denotes generates
T3640 2523-2525 CC denotes or
T3641 2526-2535 VBZ denotes increases
T3642 2536-2546 JJ denotes endogenous
T3643 2547-2554 NNS denotes ligands
T3644 2555-2558 IN denotes for
T3645 2559-2564 NN denotes PPARδ
T3646 2565-2567 IN denotes as
T3648 2568-2575 NNS denotes tissues
T3649 2576-2579 VBP denotes are
T3647 2580-2590 VBG denotes undergoing
T3650 2591-2602 JJ denotes substantial
T3651 2603-2612 NNS denotes increases
T3652 2613-2615 IN denotes in
T3653 2616-2621 JJ denotes fatty
T3655 2621-2622 HYPH denotes -
T3654 2622-2626 NN denotes acid
T3656 2627-2642 NN denotes internalization
T3657 2643-2646 CC denotes and
T3658 2647-2654 NN denotes burning
T3659 2654-2655 . denotes .
T3660 2655-2709 sentence denotes Fatty acids and their metabolites can activate PPARδ.
T3661 2656-2661 JJ denotes Fatty
T3662 2662-2667 NNS denotes acids
T3664 2668-2671 CC denotes and
T3665 2672-2677 PRP$ denotes their
T3666 2678-2689 NNS denotes metabolites
T3667 2690-2693 MD denotes can
T3663 2694-2702 VB denotes activate
T3668 2703-2708 NN denotes PPARδ
T3669 2708-2709 . denotes .
T3670 2709-2820 sentence denotes A second model is that exercise may induce expression of PGC-1α (Goto et al. 2000) and thereby activate PPARδ.
T3671 2710-2711 DT denotes A
T3673 2712-2718 JJ denotes second
T3672 2719-2724 NN denotes model
T3674 2725-2727 VBZ denotes is
T3675 2728-2732 IN denotes that
T3677 2733-2741 NN denotes exercise
T3678 2742-2745 MD denotes may
T3676 2746-2752 VB denotes induce
T3679 2753-2763 NN denotes expression
T3680 2764-2766 IN denotes of
T3681 2767-2770 NN denotes PGC
T3682 2770-2771 HYPH denotes -
T3683 2771-2773 CD denotes 1α
T3684 2774-2775 -LRB- denotes (
T3685 2775-2779 NNP denotes Goto
T3686 2780-2782 FW denotes et
T3687 2783-2786 FW denotes al.
T3688 2787-2791 CD denotes 2000
T3689 2791-2792 -RRB- denotes )
T3690 2793-2796 CC denotes and
T3691 2797-2804 RB denotes thereby
T3692 2805-2813 VBP denotes activate
T3693 2814-2819 NN denotes PPARδ
T3694 2819-2820 . denotes .
T3695 2820-3025 sentence denotes This is consistent with previous work in which we have shown that PGC-1α physically associates with PPARδ in muscle tissue and can powerfully activate it even in the absence of ligands (Wang et al. 2003).
T3696 2821-2825 DT denotes This
T3697 2826-2828 VBZ denotes is
T3698 2829-2839 JJ denotes consistent
T3699 2840-2844 IN denotes with
T3700 2845-2853 JJ denotes previous
T3701 2854-2858 NN denotes work
T3702 2859-2861 IN denotes in
T3704 2862-2867 WDT denotes which
T3705 2868-2870 PRP denotes we
T3706 2871-2875 VBP denotes have
T3703 2876-2881 VBN denotes shown
T3707 2882-2886 IN denotes that
T3709 2887-2890 NN denotes PGC
T3710 2890-2891 HYPH denotes -
T3711 2891-2893 CD denotes 1α
T3712 2894-2904 RB denotes physically
T3708 2905-2915 VBZ denotes associates
T3713 2916-2920 IN denotes with
T3714 2921-2926 NN denotes PPARδ
T3715 2927-2929 IN denotes in
T3716 2930-2936 NN denotes muscle
T3717 2937-2943 NN denotes tissue
T3718 2944-2947 CC denotes and
T3719 2948-2951 MD denotes can
T3721 2952-2962 RB denotes powerfully
T3720 2963-2971 VB denotes activate
T3722 2972-2974 PRP denotes it
T3723 2975-2979 RB denotes even
T3724 2980-2982 IN denotes in
T3725 2983-2986 DT denotes the
T3726 2987-2994 NN denotes absence
T3727 2995-2997 IN denotes of
T3728 2998-3005 NNS denotes ligands
T3729 3006-3007 -LRB- denotes (
T3730 3007-3011 NNP denotes Wang
T3731 3012-3014 FW denotes et
T3732 3015-3018 FW denotes al.
T3733 3019-3023 CD denotes 2003
T3734 3023-3024 -RRB- denotes )
T3735 3024-3025 . denotes .
T3736 3025-3130 sentence denotes Alternatively, PPARδ may be activated by a distal upstream signaling component such as a kinase cascade.
T3737 3026-3039 RB denotes Alternatively
T3739 3039-3041 , denotes ,
T3740 3041-3046 NN denotes PPARδ
T3741 3047-3050 MD denotes may
T3742 3051-3053 VB denotes be
T3738 3054-3063 VBN denotes activated
T3743 3064-3066 IN denotes by
T3744 3067-3068 DT denotes a
T3746 3069-3075 JJ denotes distal
T3747 3076-3084 JJ denotes upstream
T3748 3085-3094 NN denotes signaling
T3745 3095-3104 NN denotes component
T3749 3105-3109 JJ denotes such
T3750 3110-3112 IN denotes as
T3751 3113-3114 DT denotes a
T3753 3115-3121 NN denotes kinase
T3752 3122-3129 NN denotes cascade
T3754 3129-3130 . denotes .
T3755 3130-3330 sentence denotes Further dissecting the interactions between PPARδ and its regulatory components will be necessary to fully understand the molecular basis of muscle fiber determination pertinent to exercise training.
T3756 3131-3138 RB denotes Further
T3757 3139-3149 VBG denotes dissecting
T3759 3150-3153 DT denotes the
T3760 3154-3166 NNS denotes interactions
T3761 3167-3174 IN denotes between
T3762 3175-3180 NN denotes PPARδ
T3763 3181-3184 CC denotes and
T3764 3185-3188 PRP$ denotes its
T3766 3189-3199 JJ denotes regulatory
T3765 3200-3210 NNS denotes components
T3767 3211-3215 MD denotes will
T3758 3216-3218 VB denotes be
T3768 3219-3228 JJ denotes necessary
T3769 3229-3231 TO denotes to
T3771 3232-3237 RB denotes fully
T3770 3238-3248 VB denotes understand
T3772 3249-3252 DT denotes the
T3774 3253-3262 JJ denotes molecular
T3773 3263-3268 NN denotes basis
T3775 3269-3271 IN denotes of
T3776 3272-3278 NN denotes muscle
T3777 3279-3284 NN denotes fiber
T3778 3285-3298 NN denotes determination
T3779 3299-3308 JJ denotes pertinent
T3780 3309-3311 IN denotes to
T3781 3312-3320 NN denotes exercise
T3782 3321-3329 NN denotes training
T3783 3329-3330 . denotes .
T3784 3330-3420 sentence denotes Skeletal muscle is a major site to regulate whole-body fatty-acid and glucose metabolism.
T3785 3331-3339 JJ denotes Skeletal
T3786 3340-3346 NN denotes muscle
T3787 3347-3349 VBZ denotes is
T3788 3350-3351 DT denotes a
T3790 3352-3357 JJ denotes major
T3789 3358-3362 NN denotes site
T3791 3363-3365 TO denotes to
T3792 3366-3374 VB denotes regulate
T3793 3375-3380 JJ denotes whole
T3795 3380-3381 HYPH denotes -
T3794 3381-3385 NN denotes body
T3797 3386-3391 JJ denotes fatty
T3799 3391-3392 HYPH denotes -
T3798 3392-3396 NN denotes acid
T3800 3397-3400 CC denotes and
T3801 3401-3408 NN denotes glucose
T3796 3409-3419 NN denotes metabolism
T3802 3419-3420 . denotes .
T3803 3420-3537 sentence denotes We show that mice with increased oxidative fibers are resistant to high-fat-induced obesity and glucose intolerance.
T3804 3421-3423 PRP denotes We
T3805 3424-3428 VBP denotes show
T3806 3429-3433 IN denotes that
T3808 3434-3438 NNS denotes mice
T3809 3439-3443 IN denotes with
T3810 3444-3453 VBN denotes increased
T3812 3454-3463 JJ denotes oxidative
T3811 3464-3470 NNS denotes fibers
T3807 3471-3474 VBP denotes are
T3813 3475-3484 JJ denotes resistant
T3814 3485-3487 IN denotes to
T3815 3488-3492 JJ denotes high
T3817 3492-3493 HYPH denotes -
T3816 3493-3496 NN denotes fat
T3819 3496-3497 HYPH denotes -
T3818 3497-3504 VBN denotes induced
T3820 3505-3512 NN denotes obesity
T3821 3513-3516 CC denotes and
T3822 3517-3524 NN denotes glucose
T3823 3525-3536 NN denotes intolerance
T3824 3536-3537 . denotes .
T3825 3537-3655 sentence denotes Moreover, ligand studies provide compelling evidence that activation of endogenous PPARδ can produce similar effects.
T3826 3538-3546 RB denotes Moreover
T3828 3546-3548 , denotes ,
T3829 3548-3554 NN denotes ligand
T3830 3555-3562 NNS denotes studies
T3827 3563-3570 VBP denotes provide
T3831 3571-3581 JJ denotes compelling
T3832 3582-3590 NN denotes evidence
T3833 3591-3595 IN denotes that
T3835 3596-3606 NN denotes activation
T3836 3607-3609 IN denotes of
T3837 3610-3620 JJ denotes endogenous
T3838 3621-3626 NN denotes PPARδ
T3839 3627-3630 MD denotes can
T3834 3631-3638 VB denotes produce
T3840 3639-3646 JJ denotes similar
T3841 3647-3654 NNS denotes effects
T3842 3654-3655 . denotes .
T3843 3655-3740 sentence denotes Might PPARδ have any beneficial effects on glucose metabolism in the lean condition?
T3844 3656-3661 MD denotes Might
T3846 3662-3667 NN denotes PPARδ
T3845 3668-3672 VB denotes have
T3847 3673-3676 DT denotes any
T3849 3677-3687 JJ denotes beneficial
T3848 3688-3695 NNS denotes effects
T3850 3696-3698 IN denotes on
T3851 3699-3706 NN denotes glucose
T3852 3707-3717 NN denotes metabolism
T3853 3718-3720 IN denotes in
T3854 3721-3724 DT denotes the
T3856 3725-3729 JJ denotes lean
T3855 3730-3739 NN denotes condition
T3857 3739-3740 . denotes ?
T3858 3740-3941 sentence denotes This has not been explored; however, insulin resistance in the elderly is confined mostly to skeletal muscle and may be due to reduction of mitochondrial number and/or function (Petersen et al. 2003).
T3859 3741-3745 DT denotes This
T3861 3746-3749 VBZ denotes has
T3862 3750-3753 RB denotes not
T3863 3754-3758 VBN denotes been
T3860 3759-3767 VBN denotes explored
T3865 3767-3768 : denotes ;
T3866 3769-3776 RB denotes however
T3867 3776-3778 , denotes ,
T3868 3778-3785 NN denotes insulin
T3869 3786-3796 NN denotes resistance
T3870 3797-3799 IN denotes in
T3871 3800-3803 DT denotes the
T3872 3804-3811 JJ denotes elderly
T3873 3812-3814 VBZ denotes is
T3864 3815-3823 VBN denotes confined
T3874 3824-3830 RB denotes mostly
T3875 3831-3833 IN denotes to
T3876 3834-3842 JJ denotes skeletal
T3877 3843-3849 NN denotes muscle
T3878 3850-3853 CC denotes and
T3879 3854-3857 MD denotes may
T3880 3858-3860 VB denotes be
T3881 3861-3864 IN denotes due
T3882 3865-3867 IN denotes to
T3883 3868-3877 NN denotes reduction
T3884 3878-3880 IN denotes of
T3885 3881-3894 JJ denotes mitochondrial
T3886 3895-3901 NN denotes number
T3887 3902-3905 CC denotes and
T3888 3905-3906 HYPH denotes /
T3889 3906-3908 CC denotes or
T3890 3909-3917 NN denotes function
T3891 3918-3919 -LRB- denotes (
T3892 3919-3927 NNP denotes Petersen
T3893 3928-3930 FW denotes et
T3894 3931-3934 FW denotes al.
T3895 3935-3939 CD denotes 2003
T3896 3939-3940 -RRB- denotes )
T3897 3940-3941 . denotes .
T3898 3941-4117 sentence denotes The ability of PPARδ to stimulate mitochondrial biogenesis and oxidative function suggests that PPARδ could be important for control of insulin resistance during normal aging.
T3899 3942-3945 DT denotes The
T3900 3946-3953 NN denotes ability
T3902 3954-3956 IN denotes of
T3903 3957-3962 NN denotes PPARδ
T3904 3963-3965 TO denotes to
T3905 3966-3975 VB denotes stimulate
T3906 3976-3989 JJ denotes mitochondrial
T3907 3990-4000 NN denotes biogenesis
T3908 4001-4004 CC denotes and
T3909 4005-4014 JJ denotes oxidative
T3910 4015-4023 NN denotes function
T3901 4024-4032 VBZ denotes suggests
T3911 4033-4037 IN denotes that
T3913 4038-4043 NN denotes PPARδ
T3914 4044-4049 MD denotes could
T3912 4050-4052 VB denotes be
T3915 4053-4062 JJ denotes important
T3916 4063-4066 IN denotes for
T3917 4067-4074 NN denotes control
T3918 4075-4077 IN denotes of
T3919 4078-4085 NN denotes insulin
T3920 4086-4096 NN denotes resistance
T3921 4097-4103 IN denotes during
T3922 4104-4110 JJ denotes normal
T3923 4111-4116 NN denotes aging
T3924 4116-4117 . denotes .
T3925 4117-4331 sentence denotes Together, these data indicate that PPARδ and its ligands comprise a key molecular switch to regulate muscle fiber specification, obesity resistance, insulin sensitivity, and, most surprisingly, physical endurance.
T3926 4118-4126 RB denotes Together
T3928 4126-4128 , denotes ,
T3929 4128-4133 DT denotes these
T3930 4134-4138 NNS denotes data
T3927 4139-4147 VBP denotes indicate
T3931 4148-4152 IN denotes that
T3933 4153-4158 NN denotes PPARδ
T3934 4159-4162 CC denotes and
T3935 4163-4166 PRP$ denotes its
T3936 4167-4174 NNS denotes ligands
T3932 4175-4183 VBP denotes comprise
T3937 4184-4185 DT denotes a
T3939 4186-4189 JJ denotes key
T3940 4190-4199 JJ denotes molecular
T3938 4200-4206 NN denotes switch
T3941 4207-4209 TO denotes to
T3942 4210-4218 VB denotes regulate
T3943 4219-4225 NN denotes muscle
T3944 4226-4231 NN denotes fiber
T3945 4232-4245 NN denotes specification
T3946 4245-4247 , denotes ,
T3947 4247-4254 NN denotes obesity
T3948 4255-4265 NN denotes resistance
T3949 4265-4267 , denotes ,
T3950 4267-4274 NN denotes insulin
T3951 4275-4286 NN denotes sensitivity
T3952 4286-4288 , denotes ,
T3953 4288-4291 CC denotes and
T3954 4291-4293 , denotes ,
T3955 4293-4297 RBS denotes most
T3956 4298-4310 RB denotes surprisingly
T3958 4310-4312 , denotes ,
T3959 4312-4320 JJ denotes physical
T3957 4321-4330 NN denotes endurance
T3960 4330-4331 . denotes .
T3961 4331-4471 sentence denotes This work demonstrates that complex physiologic properties such as fatigue, endurance, and running capacity can be genetically manipulated.
T3962 4332-4336 DT denotes This
T3963 4337-4341 NN denotes work
T3964 4342-4354 VBZ denotes demonstrates
T3965 4355-4359 IN denotes that
T3967 4360-4367 JJ denotes complex
T3969 4368-4379 JJ denotes physiologic
T3968 4380-4390 NNS denotes properties
T3970 4391-4395 JJ denotes such
T3971 4396-4398 IN denotes as
T3972 4399-4406 NN denotes fatigue
T3973 4406-4408 , denotes ,
T3974 4408-4417 NN denotes endurance
T3975 4417-4419 , denotes ,
T3976 4419-4422 CC denotes and
T3977 4423-4430 NN denotes running
T3978 4431-4439 NN denotes capacity
T3979 4440-4443 MD denotes can
T3980 4444-4446 VB denotes be
T3981 4447-4458 RB denotes genetically
T3966 4459-4470 VBN denotes manipulated
T3982 4470-4471 . denotes .
R2169 T3182 T3183 poss Our,data
R2170 T3183 T3184 nsubj data,reveal
R2171 T3185 T3186 mark that,regulate
R2172 T3186 T3184 ccomp regulate,reveal
R2173 T3187 T3188 det a,pathway
R2174 T3188 T3186 nsubj pathway,regulate
R2175 T3189 T3190 npadvmod PPARδ,mediated
R2176 T3190 T3188 amod mediated,pathway
R2177 T3191 T3190 punct -,mediated
R2178 T3192 T3188 amod transcriptional,pathway
R2179 T3193 T3186 aux can,regulate
R2180 T3194 T3195 compound muscle,fiber
R2181 T3195 T3196 compound fiber,specification
R2182 T3196 T3186 dobj specification,regulate
R2183 T3197 T3186 punct ", ",regulate
R2184 T3198 T3186 advcl enabling,regulate
R2185 T3199 T3200 det the,generation
R2186 T3200 T3198 dobj generation,enabling
R2187 T3201 T3200 prep of,generation
R2188 T3202 T3203 det a,strain
R2189 T3203 T3201 pobj strain,of
R2190 T3204 T3203 prep of,strain
R2191 T3205 T3204 pobj mice,of
R2192 T3206 T3203 prep with,strain
R2193 T3207 T3208 det a,phenotype
R2194 T3208 T3206 pobj phenotype,with
R2195 T3209 T3208 punct “,phenotype
R2196 T3210 T3211 amod long,distance
R2197 T3211 T3213 nmod distance,running
R2198 T3212 T3211 punct -,distance
R2199 T3213 T3208 nmod running,phenotype
R2200 T3214 T3208 punct ”,phenotype
R2201 T3215 T3184 punct .,reveal
R2202 T3217 T3218 nsubj We,show
R2203 T3219 T3220 mark that,produces
R2204 T3220 T3218 ccomp produces,show
R2205 T3221 T3222 amod targeted,expression
R2206 T3222 T3220 nsubj expression,produces
R2207 T3223 T3222 prep of,expression
R2208 T3224 T3225 det an,form
R2209 T3225 T3223 pobj form,of
R2210 T3226 T3225 amod activated,form
R2211 T3227 T3225 prep of,form
R2212 T3228 T3227 pobj PPARδ,of
R2213 T3229 T3230 amod profound,increases
R2214 T3230 T3220 dobj increases,produces
R2215 T3231 T3229 cc and,profound
R2216 T3232 T3229 conj coordinated,profound
R2217 T3233 T3230 prep in,increases
R2218 T3234 T3235 compound oxidation,enzymes
R2219 T3235 T3233 pobj enzymes,in
R2220 T3236 T3235 punct ", ",enzymes
R2221 T3237 T3238 amod mitochondrial,biogenesis
R2222 T3238 T3235 conj biogenesis,enzymes
R2223 T3239 T3238 punct ", ",biogenesis
R2224 T3240 T3238 cc and,biogenesis
R2225 T3241 T3238 conj production,biogenesis
R2226 T3242 T3241 prep of,production
R2227 T3243 T3244 amod specialized,proteins
R2228 T3244 T3242 pobj proteins,of
R2229 T3245 T3246 nmod type,fiber
R2230 T3246 T3244 nmod fiber,proteins
R2231 T3247 T3245 nummod I,type
R2232 T3248 T3244 amod contractile,proteins
R2233 T3249 T3235 punct —,enzymes
R2234 T3250 T3251 det the,hallmarks
R2235 T3251 T3235 appos hallmarks,enzymes
R2236 T3252 T3251 nummod three,hallmarks
R2237 T3253 T3251 prep for,hallmarks
R2238 T3254 T3255 compound muscle,fiber
R2239 T3255 T3256 compound fiber,switching
R2240 T3256 T3253 pobj switching,for
R2241 T3257 T3256 compound type,switching
R2242 T3258 T3259 punct (,Figure
R2243 T3259 T3220 parataxis Figure,produces
R2244 T3260 T3259 nummod 6C,Figure
R2245 T3261 T3259 punct ),Figure
R2246 T3262 T3218 punct .,show
R2247 T3264 T3265 mark While,seen
R2248 T3265 T3275 advcl seen,are
R2249 T3266 T3265 nsubjpass induction,seen
R2250 T3267 T3266 prep of,induction
R2251 T3268 T3269 compound muscle,enzymes
R2252 T3269 T3267 pobj enzymes,of
R2253 T3270 T3269 compound oxidation,enzymes
R2254 T3271 T3266 prep by,induction
R2255 T3272 T3271 pobj PPARδ,by
R2256 T3273 T3265 aux has,seen
R2257 T3274 T3265 auxpass been,seen
R2258 T3276 T3277 preconj both,vivo
R2259 T3277 T3265 advmod vivo,seen
R2260 T3278 T3277 advmod in,vivo
R2261 T3279 T3277 cc and,vivo
R2262 T3280 T3281 advmod in,vitro
R2263 T3281 T3277 conj vitro,vivo
R2264 T3282 T3283 punct (,Muoio
R2265 T3283 T3265 meta Muoio,seen
R2266 T3284 T3283 nmod et,Muoio
R2267 T3285 T3283 nmod al.,Muoio
R2268 T3286 T3283 nummod 2002,Muoio
R2269 T3287 T3283 punct ;,Muoio
R2270 T3288 T3283 nmod Dressel,Muoio
R2271 T3289 T3283 nmod et,Muoio
R2272 T3290 T3283 nmod al.,Muoio
R2273 T3291 T3283 nummod 2003,Muoio
R2274 T3292 T3283 punct ;,Muoio
R2275 T3293 T3283 nmod Luquet,Muoio
R2276 T3294 T3283 nmod et,Muoio
R2277 T3295 T3283 nmod al.,Muoio
R2278 T3296 T3283 nummod 2003,Muoio
R2279 T3297 T3283 punct ;,Muoio
R2280 T3298 T3283 nmod Tanaka,Muoio
R2281 T3299 T3283 nmod et,Muoio
R2282 T3300 T3283 nmod al.,Muoio
R2283 T3301 T3283 nummod 2003,Muoio
R2284 T3302 T3283 punct ;,Muoio
R2285 T3303 T3283 nmod Wang,Muoio
R2286 T3304 T3283 nmod et,Muoio
R2287 T3305 T3283 nmod al.,Muoio
R2288 T3306 T3283 nummod 2003,Muoio
R2289 T3307 T3283 punct ),Muoio
R2290 T3308 T3275 punct ", ",are
R2291 T3309 T3310 poss its,effects
R2292 T3310 T3275 nsubj effects,are
R2293 T3311 T3310 acl shown,effects
R2294 T3312 T3311 advmod here,shown
R2295 T3313 T3311 prep on,shown
R2296 T3314 T3315 compound muscle,fiber
R2297 T3315 T3316 compound fiber,switching
R2298 T3316 T3313 pobj switching,on
R2299 T3317 T3275 acomp unexpected,are
R2300 T3318 T3275 punct .,are
R2301 T3320 T3321 det These,changes
R2302 T3321 T3323 nsubj changes,lead
R2303 T3322 T3321 amod progressive,changes
R2304 T3324 T3321 prep in,changes
R2305 T3325 T3326 amod oxidative,capacity
R2306 T3326 T3324 pobj capacity,in
R2307 T3327 T3321 prep in,changes
R2308 T3328 T3327 pobj conjunction,in
R2309 T3329 T3328 prep with,conjunction
R2310 T3330 T3331 amod eventual,changes
R2311 T3331 T3329 pobj changes,with
R2312 T3332 T3331 prep in,changes
R2313 T3333 T3334 nmod type,fiber
R2314 T3334 T3332 pobj fiber,in
R2315 T3335 T3333 nummod I,type
R2316 T3336 T3334 compound muscle,fiber
R2317 T3337 T3323 prep to,lead
R2318 T3338 T3339 det a,profile
R2319 T3339 T3337 pobj profile,to
R2320 T3340 T3341 advmod dramatically,improved
R2321 T3341 T3339 amod improved,profile
R2322 T3342 T3339 compound exercise,profile
R2323 T3343 T3339 cc and,profile
R2324 T3344 T3339 conj protection,profile
R2325 T3345 T3344 prep against,protection
R2326 T3346 T3345 pobj obesity,against
R2327 T3347 T3323 punct .,lead
R2328 T3349 T3350 nsubj This,depend
R2329 T3351 T3350 aux does,depend
R2330 T3352 T3350 neg not,depend
R2331 T3353 T3350 advmod solely,depend
R2332 T3354 T3350 prep on,depend
R2333 T3355 T3354 pcomp achieving,on
R2334 T3356 T3357 det a,switch
R2335 T3357 T3355 dobj switch,achieving
R2336 T3358 T3357 amod directed,switch
R2337 T3359 T3360 compound muscle,fiber
R2338 T3360 T3357 compound fiber,switch
R2339 T3361 T3357 compound type,switch
R2340 T3362 T3350 cc but,depend
R2341 T3363 T3364 advmod also,requires
R2342 T3364 T3350 conj requires,depend
R2343 T3365 T3366 predet all,changes
R2344 T3366 T3364 dobj changes,requires
R2345 T3367 T3366 det the,changes
R2346 T3368 T3366 amod associated,changes
R2347 T3369 T3366 prep in,changes
R2348 T3370 T3371 amod neural,innervation
R2349 T3371 T3369 pobj innervation,in
R2350 T3372 T3371 punct ", ",innervation
R2351 T3373 T3374 compound motor,neuron
R2352 T3374 T3375 compound neuron,function
R2353 T3375 T3371 conj function,innervation
R2354 T3376 T3375 punct ", ",function
R2355 T3377 T3375 cc and,function
R2356 T3378 T3379 amod peripheral,adaptation
R2357 T3379 T3375 conj adaptation,function
R2358 T3380 T3379 amod metabolic,adaptation
R2359 T3381 T3382 aux to,enable
R2360 T3382 T3364 advcl enable,requires
R2361 T3383 T3384 det a,response
R2362 T3384 T3382 dobj response,enable
R2363 T3385 T3384 amod new,response
R2364 T3386 T3384 amod integrated,response
R2365 T3387 T3384 amod physiological,response
R2366 T3388 T3350 punct .,depend
R2367 T3390 T3391 advmod Accordingly,recapitulates
R2368 T3392 T3391 punct ", ",recapitulates
R2369 T3393 T3391 nsubj activation,recapitulates
R2370 T3394 T3393 prep of,activation
R2371 T3395 T3396 compound muscle,PPARδ
R2372 T3396 T3394 pobj PPARδ,of
R2373 T3397 T3391 advmod essentially,recapitulates
R2374 T3398 T3399 det the,effects
R2375 T3399 T3391 dobj effects,recapitulates
R2376 T3400 T3399 prep of,effects
R2377 T3401 T3402 compound exercise,training
R2378 T3402 T3400 pobj training,of
R2379 T3403 T3404 advmod even,in
R2380 T3404 T3391 prep in,recapitulates
R2381 T3405 T3406 det the,absence
R2382 T3406 T3404 pobj absence,in
R2383 T3407 T3406 prep of,absence
R2384 T3408 T3407 pobj training,of
R2385 T3409 T3408 appos itself,training
R2386 T3410 T3391 punct .,recapitulates
R2387 T3412 T3413 prep To,described
R2388 T3414 T3415 poss our,knowledge
R2389 T3415 T3412 pobj knowledge,To
R2390 T3416 T3413 punct ", ",described
R2391 T3417 T3413 nsubjpass this,described
R2392 T3418 T3413 aux has,described
R2393 T3419 T3413 neg not,described
R2394 T3420 T3413 auxpass been,described
R2395 T3421 T3413 advmod directly,described
R2396 T3422 T3413 prep for,described
R2397 T3423 T3424 det any,factor
R2398 T3424 T3422 pobj factor,for
R2399 T3425 T3424 amod other,factor
R2400 T3426 T3424 amod transcriptional,factor
R2401 T3427 T3413 punct .,described
R2402 T3429 T3430 det The,phenotypes
R2403 T3430 T3432 nsubj phenotypes,are
R2404 T3431 T3430 compound muscle,phenotypes
R2405 T3433 T3430 acl described,phenotypes
R2406 T3434 T3433 advmod here,described
R2407 T3435 T3436 advmod remarkably,similar
R2408 T3436 T3432 acomp similar,are
R2409 T3437 T3436 prep to,similar
R2410 T3438 T3437 pobj those,to
R2411 T3439 T3438 prep of,those
R2412 T3440 T3441 amod transgenic,mice
R2413 T3441 T3439 pobj mice,of
R2414 T3442 T3441 acl expressing,mice
R2415 T3443 T3444 preconj either,calcineurin
R2416 T3444 T3442 dobj calcineurin,expressing
R2417 T3445 T3444 punct ", ",calcineurin
R2418 T3446 T3447 npadvmod calmodulin,dependent
R2419 T3447 T3449 amod dependent,kinase
R2420 T3448 T3447 punct -,dependent
R2421 T3449 T3444 conj kinase,calcineurin
R2422 T3450 T3449 punct ", ",kinase
R2423 T3451 T3449 cc or,kinase
R2424 T3452 T3449 conj PGC,kinase
R2425 T3453 T3452 punct -,PGC
R2426 T3454 T3452 nummod 1α,PGC
R2427 T3455 T3456 punct (,Naya
R2428 T3456 T3432 meta Naya,are
R2429 T3457 T3456 nmod et,Naya
R2430 T3458 T3456 nmod al.,Naya
R2431 T3459 T3456 nummod 2000,Naya
R2432 T3460 T3456 punct ;,Naya
R2433 T3461 T3456 nmod Lin,Naya
R2434 T3462 T3456 nmod et,Naya
R2435 T3463 T3456 nmod al.,Naya
R2436 T3464 T3456 nummod 2002,Naya
R2437 T3465 T3456 punct ;,Naya
R2438 T3466 T3456 nmod Wu,Naya
R2439 T3467 T3456 nmod et,Naya
R2440 T3468 T3456 nmod al.,Naya
R2441 T3469 T3456 nummod 2002,Naya
R2442 T3470 T3456 punct ),Naya
R2443 T3471 T3432 punct ", ",are
R2444 T3472 T3432 advcl indicating,are
R2445 T3473 T3474 mark that,be
R2446 T3474 T3472 ccomp be,indicating
R2447 T3475 T3474 nsubj PPARδ,be
R2448 T3476 T3474 aux could,be
R2449 T3477 T3474 attr one,be
R2450 T3478 T3477 prep of,one
R2451 T3479 T3480 det the,factors
R2452 T3480 T3478 pobj factors,of
R2453 T3481 T3480 amod hypothetical,factors
R2454 T3482 T3480 amod downstream,factors
R2455 T3483 T3480 compound transcription,factors
R2456 T3484 T3480 prep of,factors
R2457 T3485 T3486 det these,pathways
R2458 T3486 T3484 pobj pathways,of
R2459 T3487 T3432 punct .,are
R2460 T3489 T3490 nsubj It,is
R2461 T3491 T3490 acomp important,is
R2462 T3492 T3493 aux to,note
R2463 T3493 T3490 xcomp note,is
R2464 T3494 T3495 mark that,needs
R2465 T3495 T3493 ccomp needs,note
R2466 T3496 T3495 punct ", ",needs
R2467 T3497 T3495 prep from,needs
R2468 T3498 T3499 poss our,studies
R2469 T3499 T3497 pobj studies,from
R2470 T3500 T3499 nmod ligand,studies
R2471 T3501 T3500 cc and,ligand
R2472 T3502 T3500 conj gain,ligand
R2473 T3503 T3502 punct -,gain
R2474 T3504 T3502 prep of,gain
R2475 T3505 T3504 punct -,of
R2476 T3506 T3504 pobj function,of
R2477 T3507 T3499 amod transgenic,studies
R2478 T3508 T3495 punct ", ",needs
R2479 T3509 T3495 nsubj PPARδ,needs
R2480 T3510 T3511 aux to,activated
R2481 T3511 T3495 xcomp activated,needs
R2482 T3512 T3511 auxpass be,activated
R2483 T3513 T3511 prep in,activated
R2484 T3514 T3513 pobj order,in
R2485 T3515 T3516 aux to,direct
R2486 T3516 T3514 acl direct,order
R2487 T3517 T3518 det the,switch
R2488 T3518 T3516 dobj switch,direct
R2489 T3519 T3520 compound muscle,fiber
R2490 T3520 T3518 compound fiber,switch
R2491 T3521 T3490 punct .,is
R2492 T3523 T3524 advmod Indeed,found
R2493 T3525 T3524 punct ", ",found
R2494 T3526 T3524 prep in,found
R2495 T3527 T3528 det a,report
R2496 T3528 T3526 pobj report,in
R2497 T3529 T3528 amod recent,report
R2498 T3530 T3528 prep by,report
R2499 T3531 T3530 pobj Luquet,by
R2500 T3532 T3533 advmod et,al.
R2501 T3533 T3531 advmod al.,Luquet
R2502 T3534 T3531 punct (,Luquet
R2503 T3535 T3531 npadvmod 2003,Luquet
R2504 T3536 T3531 punct ),Luquet
R2505 T3537 T3524 punct ", ",found
R2506 T3538 T3539 amod simple,overexpression
R2507 T3539 T3524 nsubjpass overexpression,found
R2508 T3540 T3539 prep of,overexpression
R2509 T3541 T3542 amod wild,type
R2510 T3542 T3544 compound type,PPARδ
R2511 T3543 T3542 punct -,type
R2512 T3544 T3540 pobj PPARδ,of
R2513 T3545 T3539 prep in,overexpression
R2514 T3546 T3545 pobj muscle,in
R2515 T3547 T3524 auxpass was,found
R2516 T3548 T3549 neg not,be
R2517 T3549 T3524 xcomp be,found
R2518 T3550 T3549 aux to,be
R2519 T3551 T3549 acomp sufficient,be
R2520 T3552 T3553 aux to,promote
R2521 T3553 T3551 xcomp promote,sufficient
R2522 T3554 T3555 det a,switch
R2523 T3555 T3553 dobj switch,promote
R2524 T3556 T3555 compound fiber,switch
R2525 T3557 T3555 cc or,switch
R2526 T3558 T3559 compound obesity,resistance
R2527 T3559 T3555 conj resistance,switch
R2528 T3560 T3549 punct ", ",be
R2529 T3561 T3562 mark although,increased
R2530 T3562 T3549 advcl increased,be
R2531 T3563 T3564 amod certain,enzymes
R2532 T3564 T3562 nsubjpass enzymes,increased
R2533 T3565 T3564 compound oxidation,enzymes
R2534 T3566 T3562 auxpass were,increased
R2535 T3567 T3524 punct .,found
R2536 T3569 T3570 nsubj This,supports
R2537 T3571 T3572 det the,model
R2538 T3572 T3570 dobj model,supports
R2539 T3573 T3572 prep in,model
R2540 T3574 T3573 pobj Figure,in
R2541 T3575 T3574 nummod 6C,Figure
R2542 T3576 T3577 mark that,is
R2543 T3577 T3572 acl is,model
R2544 T3578 T3579 det the,signal
R2545 T3579 T3577 nsubj signal,is
R2546 T3580 T3579 amod activating,signal
R2547 T3581 T3579 cc or,signal
R2548 T3582 T3579 conj ligand,signal
R2549 T3583 T3579 punct ", ",signal
R2550 T3584 T3579 cc but,signal
R2551 T3585 T3584 neg not,but
R2552 T3586 T3587 det the,receptor
R2553 T3587 T3579 conj receptor,signal
R2554 T3588 T3577 punct ", ",is
R2555 T3589 T3577 acomp limiting,is
R2556 T3590 T3570 punct .,supports
R2557 T3592 T3593 advmod Thus,is
R2558 T3594 T3593 punct ", ",is
R2559 T3595 T3596 compound PPARδ,activation
R2560 T3596 T3593 nsubj activation,is
R2561 T3597 T3596 punct ", ",activation
R2562 T3598 T3599 advmod rather,than
R2563 T3599 T3596 cc than,activation
R2564 T3600 T3601 advmod merely,increase
R2565 T3601 T3596 conj increase,activation
R2566 T3602 T3601 det an,increase
R2567 T3603 T3601 prep of,increase
R2568 T3604 T3605 compound PPARδ,levels
R2569 T3605 T3603 pobj levels,of
R2570 T3606 T3593 punct ", ",is
R2571 T3607 T3608 det an,element
R2572 T3608 T3593 attr element,is
R2573 T3609 T3608 amod essential,element
R2574 T3610 T3608 prep for,element
R2575 T3611 T3612 compound fiber,switching
R2576 T3612 T3610 pobj switching,for
R2577 T3613 T3612 cc and,switching
R2578 T3614 T3615 poss its,manifestations
R2579 T3615 T3612 conj manifestations,switching
R2580 T3616 T3615 amod associated,manifestations
R2581 T3617 T3615 amod functional,manifestations
R2582 T3618 T3593 punct .,is
R2583 T3620 T3621 advmod How,become
R2584 T3622 T3621 aux might,become
R2585 T3623 T3624 amod endogenous,PPARδ
R2586 T3624 T3621 nsubj PPARδ,become
R2587 T3625 T3621 acomp activated,become
R2588 T3626 T3621 advmod naturally,become
R2589 T3627 T3621 prep by,become
R2590 T3628 T3629 compound exercise,training
R2591 T3629 T3627 pobj training,by
R2592 T3630 T3621 punct ?,become
R2593 T3632 T3633 advmod First,is
R2594 T3634 T3633 punct ", ",is
R2595 T3635 T3633 nsubj it,is
R2596 T3636 T3633 acomp possible,is
R2597 T3637 T3638 mark that,generates
R2598 T3638 T3633 ccomp generates,is
R2599 T3639 T3638 nsubj exercise,generates
R2600 T3640 T3638 cc or,generates
R2601 T3641 T3638 conj increases,generates
R2602 T3642 T3643 amod endogenous,ligands
R2603 T3643 T3641 dobj ligands,increases
R2604 T3644 T3641 prep for,increases
R2605 T3645 T3644 pobj PPARδ,for
R2606 T3646 T3647 mark as,undergoing
R2607 T3647 T3641 advcl undergoing,increases
R2608 T3648 T3647 nsubj tissues,undergoing
R2609 T3649 T3647 aux are,undergoing
R2610 T3650 T3651 amod substantial,increases
R2611 T3651 T3647 dobj increases,undergoing
R2612 T3652 T3651 prep in,increases
R2613 T3653 T3654 amod fatty,acid
R2614 T3654 T3652 pobj acid,in
R2615 T3655 T3654 punct -,acid
R2616 T3656 T3654 appos internalization,acid
R2617 T3657 T3656 cc and,internalization
R2618 T3658 T3656 conj burning,internalization
R2619 T3659 T3633 punct .,is
R2620 T3661 T3662 amod Fatty,acids
R2621 T3662 T3663 nsubj acids,activate
R2622 T3664 T3662 cc and,acids
R2623 T3665 T3666 poss their,metabolites
R2624 T3666 T3662 conj metabolites,acids
R2625 T3667 T3663 aux can,activate
R2626 T3668 T3663 dobj PPARδ,activate
R2627 T3669 T3663 punct .,activate
R2628 T3671 T3672 det A,model
R2629 T3672 T3674 nsubj model,is
R2630 T3673 T3672 amod second,model
R2631 T3675 T3676 mark that,induce
R2632 T3676 T3674 ccomp induce,is
R2633 T3677 T3676 nsubj exercise,induce
R2634 T3678 T3676 aux may,induce
R2635 T3679 T3676 dobj expression,induce
R2636 T3680 T3679 prep of,expression
R2637 T3681 T3680 pobj PGC,of
R2638 T3682 T3681 punct -,PGC
R2639 T3683 T3681 nummod 1α,PGC
R2640 T3684 T3685 punct (,Goto
R2641 T3685 T3676 meta Goto,induce
R2642 T3686 T3685 nmod et,Goto
R2643 T3687 T3685 nmod al.,Goto
R2644 T3688 T3685 nummod 2000,Goto
R2645 T3689 T3685 punct ),Goto
R2646 T3690 T3676 cc and,induce
R2647 T3691 T3692 advmod thereby,activate
R2648 T3692 T3676 conj activate,induce
R2649 T3693 T3692 dobj PPARδ,activate
R2650 T3694 T3674 punct .,is
R2651 T3696 T3697 nsubj This,is
R2652 T3698 T3697 acomp consistent,is
R2653 T3699 T3698 prep with,consistent
R2654 T3700 T3701 amod previous,work
R2655 T3701 T3699 pobj work,with
R2656 T3702 T3703 prep in,shown
R2657 T3703 T3701 relcl shown,work
R2658 T3704 T3702 pobj which,in
R2659 T3705 T3703 nsubj we,shown
R2660 T3706 T3703 aux have,shown
R2661 T3707 T3708 mark that,associates
R2662 T3708 T3703 ccomp associates,shown
R2663 T3709 T3708 nsubj PGC,associates
R2664 T3710 T3709 punct -,PGC
R2665 T3711 T3709 nummod 1α,PGC
R2666 T3712 T3708 advmod physically,associates
R2667 T3713 T3708 prep with,associates
R2668 T3714 T3713 pobj PPARδ,with
R2669 T3715 T3708 prep in,associates
R2670 T3716 T3717 compound muscle,tissue
R2671 T3717 T3715 pobj tissue,in
R2672 T3718 T3708 cc and,associates
R2673 T3719 T3720 aux can,activate
R2674 T3720 T3708 conj activate,associates
R2675 T3721 T3720 advmod powerfully,activate
R2676 T3722 T3720 dobj it,activate
R2677 T3723 T3724 advmod even,in
R2678 T3724 T3720 prep in,activate
R2679 T3725 T3726 det the,absence
R2680 T3726 T3724 pobj absence,in
R2681 T3727 T3726 prep of,absence
R2682 T3728 T3727 pobj ligands,of
R2683 T3729 T3730 punct (,Wang
R2684 T3730 T3703 meta Wang,shown
R2685 T3731 T3730 nmod et,Wang
R2686 T3732 T3730 nmod al.,Wang
R2687 T3733 T3730 nummod 2003,Wang
R2688 T3734 T3730 punct ),Wang
R2689 T3735 T3697 punct .,is
R2690 T3737 T3738 advmod Alternatively,activated
R2691 T3739 T3738 punct ", ",activated
R2692 T3740 T3738 nsubjpass PPARδ,activated
R2693 T3741 T3738 aux may,activated
R2694 T3742 T3738 auxpass be,activated
R2695 T3743 T3738 agent by,activated
R2696 T3744 T3745 det a,component
R2697 T3745 T3743 pobj component,by
R2698 T3746 T3745 amod distal,component
R2699 T3747 T3745 amod upstream,component
R2700 T3748 T3745 compound signaling,component
R2701 T3749 T3750 amod such,as
R2702 T3750 T3745 prep as,component
R2703 T3751 T3752 det a,cascade
R2704 T3752 T3750 pobj cascade,as
R2705 T3753 T3752 compound kinase,cascade
R2706 T3754 T3738 punct .,activated
R2707 T3756 T3757 advmod Further,dissecting
R2708 T3757 T3758 csubj dissecting,be
R2709 T3759 T3760 det the,interactions
R2710 T3760 T3757 dobj interactions,dissecting
R2711 T3761 T3760 prep between,interactions
R2712 T3762 T3761 pobj PPARδ,between
R2713 T3763 T3762 cc and,PPARδ
R2714 T3764 T3765 poss its,components
R2715 T3765 T3762 conj components,PPARδ
R2716 T3766 T3765 amod regulatory,components
R2717 T3767 T3758 aux will,be
R2718 T3768 T3758 acomp necessary,be
R2719 T3769 T3770 aux to,understand
R2720 T3770 T3758 advcl understand,be
R2721 T3771 T3770 advmod fully,understand
R2722 T3772 T3773 det the,basis
R2723 T3773 T3770 dobj basis,understand
R2724 T3774 T3773 amod molecular,basis
R2725 T3775 T3773 prep of,basis
R2726 T3776 T3777 compound muscle,fiber
R2727 T3777 T3778 compound fiber,determination
R2728 T3778 T3775 pobj determination,of
R2729 T3779 T3773 amod pertinent,basis
R2730 T3780 T3779 prep to,pertinent
R2731 T3781 T3782 compound exercise,training
R2732 T3782 T3780 pobj training,to
R2733 T3783 T3758 punct .,be
R2734 T3785 T3786 amod Skeletal,muscle
R2735 T3786 T3787 nsubj muscle,is
R2736 T3788 T3789 det a,site
R2737 T3789 T3787 attr site,is
R2738 T3790 T3789 amod major,site
R2739 T3791 T3792 aux to,regulate
R2740 T3792 T3789 advcl regulate,site
R2741 T3793 T3794 amod whole,body
R2742 T3794 T3796 nmod body,metabolism
R2743 T3795 T3794 punct -,body
R2744 T3796 T3792 dobj metabolism,regulate
R2745 T3797 T3798 amod fatty,acid
R2746 T3798 T3796 nmod acid,metabolism
R2747 T3799 T3798 punct -,acid
R2748 T3800 T3798 cc and,acid
R2749 T3801 T3798 conj glucose,acid
R2750 T3802 T3787 punct .,is
R2751 T3804 T3805 nsubj We,show
R2752 T3806 T3807 mark that,are
R2753 T3807 T3805 ccomp are,show
R2754 T3808 T3807 nsubj mice,are
R2755 T3809 T3808 prep with,mice
R2756 T3810 T3811 amod increased,fibers
R2757 T3811 T3809 pobj fibers,with
R2758 T3812 T3811 amod oxidative,fibers
R2759 T3813 T3807 acomp resistant,are
R2760 T3814 T3813 prep to,resistant
R2761 T3815 T3816 amod high,fat
R2762 T3816 T3818 npadvmod fat,induced
R2763 T3817 T3816 punct -,fat
R2764 T3818 T3820 amod induced,obesity
R2765 T3819 T3818 punct -,induced
R2766 T3820 T3814 pobj obesity,to
R2767 T3821 T3820 cc and,obesity
R2768 T3822 T3823 compound glucose,intolerance
R2769 T3823 T3820 conj intolerance,obesity
R2770 T3824 T3805 punct .,show
R2771 T3826 T3827 advmod Moreover,provide
R2772 T3828 T3827 punct ", ",provide
R2773 T3829 T3830 compound ligand,studies
R2774 T3830 T3827 nsubj studies,provide
R2775 T3831 T3832 amod compelling,evidence
R2776 T3832 T3827 dobj evidence,provide
R2777 T3833 T3834 mark that,produce
R2778 T3834 T3832 acl produce,evidence
R2779 T3835 T3834 nsubj activation,produce
R2780 T3836 T3835 prep of,activation
R2781 T3837 T3838 amod endogenous,PPARδ
R2782 T3838 T3836 pobj PPARδ,of
R2783 T3839 T3834 aux can,produce
R2784 T3840 T3841 amod similar,effects
R2785 T3841 T3834 dobj effects,produce
R2786 T3842 T3827 punct .,provide
R2787 T3844 T3845 aux Might,have
R2788 T3846 T3845 nsubj PPARδ,have
R2789 T3847 T3848 det any,effects
R2790 T3848 T3845 dobj effects,have
R2791 T3849 T3848 amod beneficial,effects
R2792 T3850 T3848 prep on,effects
R2793 T3851 T3852 compound glucose,metabolism
R2794 T3852 T3850 pobj metabolism,on
R2795 T3853 T3845 prep in,have
R2796 T3854 T3855 det the,condition
R2797 T3855 T3853 pobj condition,in
R2798 T3856 T3855 amod lean,condition
R2799 T3857 T3845 punct ?,have
R2800 T3859 T3860 nsubjpass This,explored
R2801 T3860 T3864 ccomp explored,confined
R2802 T3861 T3860 aux has,explored
R2803 T3862 T3860 neg not,explored
R2804 T3863 T3860 auxpass been,explored
R2805 T3865 T3864 punct ;,confined
R2806 T3866 T3864 advmod however,confined
R2807 T3867 T3864 punct ", ",confined
R2808 T3868 T3869 compound insulin,resistance
R2809 T3869 T3864 nsubjpass resistance,confined
R2810 T3870 T3869 prep in,resistance
R2811 T3871 T3872 det the,elderly
R2812 T3872 T3870 pobj elderly,in
R2813 T3873 T3864 auxpass is,confined
R2814 T3874 T3875 advmod mostly,to
R2815 T3875 T3864 prep to,confined
R2816 T3876 T3877 amod skeletal,muscle
R2817 T3877 T3875 pobj muscle,to
R2818 T3878 T3864 cc and,confined
R2819 T3879 T3880 aux may,be
R2820 T3880 T3864 conj be,confined
R2821 T3881 T3880 prep due,be
R2822 T3882 T3881 pcomp to,due
R2823 T3883 T3881 pobj reduction,due
R2824 T3884 T3883 prep of,reduction
R2825 T3885 T3886 amod mitochondrial,number
R2826 T3886 T3884 pobj number,of
R2827 T3887 T3886 cc and,number
R2828 T3888 T3887 punct /,and
R2829 T3889 T3887 cc or,and
R2830 T3890 T3886 conj function,number
R2831 T3891 T3892 punct (,Petersen
R2832 T3892 T3880 meta Petersen,be
R2833 T3893 T3892 nmod et,Petersen
R2834 T3894 T3892 nmod al.,Petersen
R2835 T3895 T3892 nummod 2003,Petersen
R2836 T3896 T3892 punct ),Petersen
R2837 T3897 T3864 punct .,confined
R2838 T3899 T3900 det The,ability
R2839 T3900 T3901 nsubj ability,suggests
R2840 T3902 T3900 prep of,ability
R2841 T3903 T3902 pobj PPARδ,of
R2842 T3904 T3905 aux to,stimulate
R2843 T3905 T3900 acl stimulate,ability
R2844 T3906 T3907 amod mitochondrial,biogenesis
R2845 T3907 T3905 dobj biogenesis,stimulate
R2846 T3908 T3907 cc and,biogenesis
R2847 T3909 T3910 amod oxidative,function
R2848 T3910 T3907 conj function,biogenesis
R2849 T3911 T3912 mark that,be
R2850 T3912 T3901 ccomp be,suggests
R2851 T3913 T3912 nsubj PPARδ,be
R2852 T3914 T3912 aux could,be
R2853 T3915 T3912 acomp important,be
R2854 T3916 T3912 prep for,be
R2855 T3917 T3916 pobj control,for
R2856 T3918 T3917 prep of,control
R2857 T3919 T3920 compound insulin,resistance
R2858 T3920 T3918 pobj resistance,of
R2859 T3921 T3912 prep during,be
R2860 T3922 T3923 amod normal,aging
R2861 T3923 T3921 pobj aging,during
R2862 T3924 T3901 punct .,suggests
R2863 T3926 T3927 advmod Together,indicate
R2864 T3928 T3927 punct ", ",indicate
R2865 T3929 T3930 det these,data
R2866 T3930 T3927 nsubj data,indicate
R2867 T3931 T3932 mark that,comprise
R2868 T3932 T3927 ccomp comprise,indicate
R2869 T3933 T3932 nsubj PPARδ,comprise
R2870 T3934 T3933 cc and,PPARδ
R2871 T3935 T3936 poss its,ligands
R2872 T3936 T3933 conj ligands,PPARδ
R2873 T3937 T3938 det a,switch
R2874 T3938 T3932 dobj switch,comprise
R2875 T3939 T3938 amod key,switch
R2876 T3940 T3938 amod molecular,switch
R2877 T3941 T3942 aux to,regulate
R2878 T3942 T3938 advcl regulate,switch
R2879 T3943 T3944 compound muscle,fiber
R2880 T3944 T3945 compound fiber,specification
R2881 T3945 T3942 dobj specification,regulate
R2882 T3946 T3945 punct ", ",specification
R2883 T3947 T3948 compound obesity,resistance
R2884 T3948 T3945 conj resistance,specification
R2885 T3949 T3948 punct ", ",resistance
R2886 T3950 T3951 compound insulin,sensitivity
R2887 T3951 T3948 conj sensitivity,resistance
R2888 T3952 T3951 punct ", ",sensitivity
R2889 T3953 T3951 cc and,sensitivity
R2890 T3954 T3951 punct ", ",sensitivity
R2891 T3955 T3956 advmod most,surprisingly
R2892 T3956 T3957 advmod surprisingly,endurance
R2893 T3957 T3951 conj endurance,sensitivity
R2894 T3958 T3957 punct ", ",endurance
R2895 T3959 T3957 amod physical,endurance
R2896 T3960 T3927 punct .,indicate
R2897 T3962 T3963 det This,work
R2898 T3963 T3964 nsubj work,demonstrates
R2899 T3965 T3966 mark that,manipulated
R2900 T3966 T3964 ccomp manipulated,demonstrates
R2901 T3967 T3968 amod complex,properties
R2902 T3968 T3966 nsubjpass properties,manipulated
R2903 T3969 T3968 amod physiologic,properties
R2904 T3970 T3971 amod such,as
R2905 T3971 T3968 prep as,properties
R2906 T3972 T3971 pobj fatigue,as
R2907 T3973 T3972 punct ", ",fatigue
R2908 T3974 T3972 conj endurance,fatigue
R2909 T3975 T3974 punct ", ",endurance
R2910 T3976 T3974 cc and,endurance
R2911 T3977 T3978 compound running,capacity
R2912 T3978 T3974 conj capacity,endurance
R2913 T3979 T3966 aux can,manipulated
R2914 T3980 T3966 auxpass be,manipulated
R2915 T3981 T3966 advmod genetically,manipulated
R2916 T3982 T3964 punct .,demonstrates