Id |
Subject |
Object |
Predicate |
Lexical cue |
T2224 |
0-1 |
DT |
denotes |
A |
T2225 |
2-8 |
NN |
denotes |
number |
T2227 |
9-11 |
IN |
denotes |
of |
T2228 |
12-20 |
JJ |
denotes |
previous |
T2229 |
21-28 |
NNS |
denotes |
studies |
T2230 |
29-33 |
VBP |
denotes |
have |
T2226 |
34-39 |
VBN |
denotes |
shown |
T2231 |
40-44 |
IN |
denotes |
that |
T2233 |
45-50 |
JJ |
denotes |
obese |
T2234 |
51-62 |
NNS |
denotes |
individuals |
T2232 |
63-67 |
VBP |
denotes |
have |
T2235 |
68-73 |
JJR |
denotes |
fewer |
T2237 |
74-83 |
JJ |
denotes |
oxidative |
T2236 |
84-90 |
NNS |
denotes |
fibers |
T2238 |
90-92 |
, |
denotes |
, |
T2239 |
92-100 |
VBG |
denotes |
implying |
T2240 |
101-105 |
IN |
denotes |
that |
T2242 |
106-109 |
DT |
denotes |
the |
T2243 |
110-118 |
NN |
denotes |
presence |
T2244 |
119-121 |
IN |
denotes |
of |
T2245 |
122-131 |
JJ |
denotes |
oxidative |
T2246 |
132-138 |
NNS |
denotes |
fibers |
T2247 |
139-144 |
RB |
denotes |
alone |
T2248 |
145-148 |
MD |
denotes |
may |
T2241 |
149-153 |
VB |
denotes |
play |
T2249 |
154-155 |
DT |
denotes |
a |
T2250 |
156-160 |
NN |
denotes |
part |
T2251 |
161-163 |
IN |
denotes |
in |
T2252 |
164-171 |
NN |
denotes |
obesity |
T2253 |
172-182 |
NN |
denotes |
resistance |
T2254 |
182-183 |
. |
denotes |
. |
T2255 |
183-299 |
sentence |
denotes |
To test this possibility, we fed the transgenic mice and their wild-type littermates with a high-fat diet for 97 d. |
T2256 |
184-186 |
TO |
denotes |
To |
T2257 |
187-191 |
VB |
denotes |
test |
T2259 |
192-196 |
DT |
denotes |
this |
T2260 |
197-208 |
NN |
denotes |
possibility |
T2261 |
208-210 |
, |
denotes |
, |
T2262 |
210-212 |
PRP |
denotes |
we |
T2258 |
213-216 |
VBD |
denotes |
fed |
T2263 |
217-220 |
DT |
denotes |
the |
T2265 |
221-231 |
JJ |
denotes |
transgenic |
T2264 |
232-236 |
NNS |
denotes |
mice |
T2266 |
237-240 |
CC |
denotes |
and |
T2267 |
241-246 |
PRP$ |
denotes |
their |
T2269 |
247-251 |
JJ |
denotes |
wild |
T2271 |
251-252 |
HYPH |
denotes |
- |
T2270 |
252-256 |
NN |
denotes |
type |
T2268 |
257-268 |
NNS |
denotes |
littermates |
T2272 |
269-273 |
IN |
denotes |
with |
T2273 |
274-275 |
DT |
denotes |
a |
T2275 |
276-280 |
JJ |
denotes |
high |
T2277 |
280-281 |
HYPH |
denotes |
- |
T2276 |
281-284 |
NN |
denotes |
fat |
T2274 |
285-289 |
NN |
denotes |
diet |
T2278 |
290-293 |
IN |
denotes |
for |
T2279 |
294-296 |
CD |
denotes |
97 |
T2280 |
297-298 |
NNS |
denotes |
d |
T2281 |
298-299 |
. |
denotes |
. |
T2282 |
299-515 |
sentence |
denotes |
Although the initial body weights of the two groups were very similar, the transgenic mice had gained less than 50% at day 47, and only one-third at day 97, of the weight gained by the wild-type animals (Figure 4A). |
T2283 |
300-308 |
IN |
denotes |
Although |
T2285 |
309-312 |
DT |
denotes |
the |
T2287 |
313-320 |
JJ |
denotes |
initial |
T2288 |
321-325 |
NN |
denotes |
body |
T2286 |
326-333 |
NNS |
denotes |
weights |
T2289 |
334-336 |
IN |
denotes |
of |
T2290 |
337-340 |
DT |
denotes |
the |
T2292 |
341-344 |
CD |
denotes |
two |
T2291 |
345-351 |
NNS |
denotes |
groups |
T2284 |
352-356 |
VBD |
denotes |
were |
T2294 |
357-361 |
RB |
denotes |
very |
T2295 |
362-369 |
JJ |
denotes |
similar |
T2296 |
369-371 |
, |
denotes |
, |
T2297 |
371-374 |
DT |
denotes |
the |
T2299 |
375-385 |
JJ |
denotes |
transgenic |
T2298 |
386-390 |
NNS |
denotes |
mice |
T2300 |
391-394 |
VBD |
denotes |
had |
T2293 |
395-401 |
VBN |
denotes |
gained |
T2301 |
402-406 |
JJR |
denotes |
less |
T2303 |
407-411 |
IN |
denotes |
than |
T2302 |
412-414 |
CD |
denotes |
50 |
T2304 |
414-415 |
NN |
denotes |
% |
T2305 |
416-418 |
IN |
denotes |
at |
T2306 |
419-422 |
NN |
denotes |
day |
T2307 |
423-425 |
CD |
denotes |
47 |
T2308 |
425-427 |
, |
denotes |
, |
T2309 |
427-430 |
CC |
denotes |
and |
T2310 |
431-435 |
RB |
denotes |
only |
T2312 |
436-439 |
RB |
denotes |
one |
T2313 |
439-440 |
HYPH |
denotes |
- |
T2311 |
440-445 |
RB |
denotes |
third |
T2314 |
446-448 |
IN |
denotes |
at |
T2315 |
449-452 |
NN |
denotes |
day |
T2316 |
453-455 |
CD |
denotes |
97 |
T2317 |
455-457 |
, |
denotes |
, |
T2318 |
457-459 |
IN |
denotes |
of |
T2319 |
460-463 |
DT |
denotes |
the |
T2320 |
464-470 |
NN |
denotes |
weight |
T2321 |
471-477 |
VBN |
denotes |
gained |
T2322 |
478-480 |
IN |
denotes |
by |
T2323 |
481-484 |
DT |
denotes |
the |
T2325 |
485-489 |
JJ |
denotes |
wild |
T2327 |
489-490 |
HYPH |
denotes |
- |
T2326 |
490-494 |
NN |
denotes |
type |
T2324 |
495-502 |
NNS |
denotes |
animals |
T2328 |
503-504 |
-LRB- |
denotes |
( |
T2329 |
504-510 |
NN |
denotes |
Figure |
T2330 |
511-513 |
CD |
denotes |
4A |
T2331 |
513-514 |
-RRB- |
denotes |
) |
T2332 |
514-515 |
. |
denotes |
. |
T2333 |
515-655 |
sentence |
denotes |
The transgenic mice displayed significantly higher oxygen consumption on the high-fat diet than the control littermates (unpublished data). |
T2334 |
516-519 |
DT |
denotes |
The |
T2336 |
520-530 |
JJ |
denotes |
transgenic |
T2335 |
531-535 |
NNS |
denotes |
mice |
T2337 |
536-545 |
VBD |
denotes |
displayed |
T2338 |
546-559 |
RB |
denotes |
significantly |
T2339 |
560-566 |
JJR |
denotes |
higher |
T2341 |
567-573 |
NN |
denotes |
oxygen |
T2340 |
574-585 |
NN |
denotes |
consumption |
T2342 |
586-588 |
IN |
denotes |
on |
T2343 |
589-592 |
DT |
denotes |
the |
T2345 |
593-597 |
JJ |
denotes |
high |
T2347 |
597-598 |
HYPH |
denotes |
- |
T2346 |
598-601 |
NN |
denotes |
fat |
T2344 |
602-606 |
NN |
denotes |
diet |
T2348 |
607-611 |
IN |
denotes |
than |
T2349 |
612-615 |
DT |
denotes |
the |
T2351 |
616-623 |
NN |
denotes |
control |
T2350 |
624-635 |
NNS |
denotes |
littermates |
T2352 |
636-637 |
-LRB- |
denotes |
( |
T2354 |
637-648 |
JJ |
denotes |
unpublished |
T2353 |
649-653 |
NNS |
denotes |
data |
T2355 |
653-654 |
-RRB- |
denotes |
) |
T2356 |
654-655 |
. |
denotes |
. |
T2357 |
655-828 |
sentence |
denotes |
By the end of this experiment, the control littermates became obese, whereas the transgenic mice still maintained a normal body weight and fat mass composition (Figure 4A). |
T2358 |
656-658 |
IN |
denotes |
By |
T2360 |
659-662 |
DT |
denotes |
the |
T2361 |
663-666 |
NN |
denotes |
end |
T2362 |
667-669 |
IN |
denotes |
of |
T2363 |
670-674 |
DT |
denotes |
this |
T2364 |
675-685 |
NN |
denotes |
experiment |
T2365 |
685-687 |
, |
denotes |
, |
T2366 |
687-690 |
DT |
denotes |
the |
T2368 |
691-698 |
NN |
denotes |
control |
T2367 |
699-710 |
NNS |
denotes |
littermates |
T2359 |
711-717 |
VBD |
denotes |
became |
T2369 |
718-723 |
JJ |
denotes |
obese |
T2370 |
723-725 |
, |
denotes |
, |
T2371 |
725-732 |
IN |
denotes |
whereas |
T2373 |
733-736 |
DT |
denotes |
the |
T2375 |
737-747 |
JJ |
denotes |
transgenic |
T2374 |
748-752 |
NNS |
denotes |
mice |
T2376 |
753-758 |
RB |
denotes |
still |
T2372 |
759-769 |
VBD |
denotes |
maintained |
T2377 |
770-771 |
DT |
denotes |
a |
T2379 |
772-778 |
JJ |
denotes |
normal |
T2380 |
779-783 |
NN |
denotes |
body |
T2378 |
784-790 |
NN |
denotes |
weight |
T2381 |
791-794 |
CC |
denotes |
and |
T2382 |
795-798 |
NN |
denotes |
fat |
T2383 |
799-803 |
NN |
denotes |
mass |
T2384 |
804-815 |
NN |
denotes |
composition |
T2385 |
816-817 |
-LRB- |
denotes |
( |
T2386 |
817-823 |
NN |
denotes |
Figure |
T2387 |
824-826 |
CD |
denotes |
4A |
T2388 |
826-827 |
-RRB- |
denotes |
) |
T2389 |
827-828 |
. |
denotes |
. |
T2390 |
828-990 |
sentence |
denotes |
A histological analysis of inguinal fat pad revealed a much smaller cell size in the transgenic mice (Figure 4B), due to the increased muscle oxidative capacity. |
T2391 |
829-830 |
DT |
denotes |
A |
T2393 |
831-843 |
JJ |
denotes |
histological |
T2392 |
844-852 |
NN |
denotes |
analysis |
T2395 |
853-855 |
IN |
denotes |
of |
T2396 |
856-864 |
JJ |
denotes |
inguinal |
T2398 |
865-868 |
NN |
denotes |
fat |
T2397 |
869-872 |
NN |
denotes |
pad |
T2394 |
873-881 |
VBD |
denotes |
revealed |
T2399 |
882-883 |
DT |
denotes |
a |
T2401 |
884-888 |
RB |
denotes |
much |
T2402 |
889-896 |
JJR |
denotes |
smaller |
T2403 |
897-901 |
NN |
denotes |
cell |
T2400 |
902-906 |
NN |
denotes |
size |
T2404 |
907-909 |
IN |
denotes |
in |
T2405 |
910-913 |
DT |
denotes |
the |
T2407 |
914-924 |
JJ |
denotes |
transgenic |
T2406 |
925-929 |
NNS |
denotes |
mice |
T2408 |
930-931 |
-LRB- |
denotes |
( |
T2409 |
931-937 |
NN |
denotes |
Figure |
T2410 |
938-940 |
CD |
denotes |
4B |
T2411 |
940-941 |
-RRB- |
denotes |
) |
T2412 |
941-943 |
, |
denotes |
, |
T2413 |
943-946 |
IN |
denotes |
due |
T2414 |
947-949 |
IN |
denotes |
to |
T2415 |
950-953 |
DT |
denotes |
the |
T2417 |
954-963 |
VBN |
denotes |
increased |
T2418 |
964-970 |
NN |
denotes |
muscle |
T2419 |
971-980 |
JJ |
denotes |
oxidative |
T2416 |
981-989 |
NN |
denotes |
capacity |
T2420 |
989-990 |
. |
denotes |
. |
T2421 |
990-1213 |
sentence |
denotes |
While there was no significant difference in intramuscular glycogen content, the triglyceride content was much less in the transgenic mice (Figure 4C and 4D), which may explain their improved glucose tolerance (Figure 4E). |
T2422 |
991-996 |
IN |
denotes |
While |
T2424 |
997-1002 |
EX |
denotes |
there |
T2423 |
1003-1006 |
VBD |
denotes |
was |
T2426 |
1007-1009 |
DT |
denotes |
no |
T2428 |
1010-1021 |
JJ |
denotes |
significant |
T2427 |
1022-1032 |
NN |
denotes |
difference |
T2429 |
1033-1035 |
IN |
denotes |
in |
T2430 |
1036-1049 |
JJ |
denotes |
intramuscular |
T2432 |
1050-1058 |
NN |
denotes |
glycogen |
T2431 |
1059-1066 |
NN |
denotes |
content |
T2433 |
1066-1068 |
, |
denotes |
, |
T2434 |
1068-1071 |
DT |
denotes |
the |
T2436 |
1072-1084 |
NN |
denotes |
triglyceride |
T2435 |
1085-1092 |
NN |
denotes |
content |
T2425 |
1093-1096 |
VBD |
denotes |
was |
T2437 |
1097-1101 |
RB |
denotes |
much |
T2438 |
1102-1106 |
JJR |
denotes |
less |
T2439 |
1107-1109 |
IN |
denotes |
in |
T2440 |
1110-1113 |
DT |
denotes |
the |
T2442 |
1114-1124 |
JJ |
denotes |
transgenic |
T2441 |
1125-1129 |
NNS |
denotes |
mice |
T2443 |
1130-1131 |
-LRB- |
denotes |
( |
T2444 |
1131-1137 |
NN |
denotes |
Figure |
T2445 |
1138-1140 |
CD |
denotes |
4C |
T2446 |
1141-1144 |
CC |
denotes |
and |
T2447 |
1145-1147 |
CD |
denotes |
4D |
T2448 |
1147-1148 |
-RRB- |
denotes |
) |
T2449 |
1148-1150 |
, |
denotes |
, |
T2450 |
1150-1155 |
WDT |
denotes |
which |
T2452 |
1156-1159 |
MD |
denotes |
may |
T2451 |
1160-1167 |
VB |
denotes |
explain |
T2453 |
1168-1173 |
PRP$ |
denotes |
their |
T2455 |
1174-1182 |
VBN |
denotes |
improved |
T2456 |
1183-1190 |
NN |
denotes |
glucose |
T2454 |
1191-1200 |
NN |
denotes |
tolerance |
T2457 |
1201-1202 |
-LRB- |
denotes |
( |
T2458 |
1202-1208 |
NN |
denotes |
Figure |
T2459 |
1209-1211 |
CD |
denotes |
4E |
T2460 |
1211-1212 |
-RRB- |
denotes |
) |
T2461 |
1212-1213 |
. |
denotes |
. |
T2462 |
1213-1348 |
sentence |
denotes |
We also placed wild-type C57BJ6 mice on the high-fat diet and treated them with either vehicle or the PPARδ agonist GW501516 for 2 mo. |
T2463 |
1214-1216 |
PRP |
denotes |
We |
T2465 |
1217-1221 |
RB |
denotes |
also |
T2464 |
1222-1228 |
VBD |
denotes |
placed |
T2466 |
1229-1233 |
JJ |
denotes |
wild |
T2468 |
1233-1234 |
HYPH |
denotes |
- |
T2467 |
1234-1238 |
NN |
denotes |
type |
T2470 |
1239-1245 |
NN |
denotes |
C57BJ6 |
T2469 |
1246-1250 |
NNS |
denotes |
mice |
T2471 |
1251-1253 |
IN |
denotes |
on |
T2472 |
1254-1257 |
DT |
denotes |
the |
T2474 |
1258-1262 |
JJ |
denotes |
high |
T2476 |
1262-1263 |
HYPH |
denotes |
- |
T2475 |
1263-1266 |
NN |
denotes |
fat |
T2473 |
1267-1271 |
NN |
denotes |
diet |
T2477 |
1272-1275 |
CC |
denotes |
and |
T2478 |
1276-1283 |
VBN |
denotes |
treated |
T2479 |
1284-1288 |
PRP |
denotes |
them |
T2480 |
1289-1293 |
IN |
denotes |
with |
T2481 |
1294-1300 |
CC |
denotes |
either |
T2482 |
1301-1308 |
NN |
denotes |
vehicle |
T2483 |
1309-1311 |
CC |
denotes |
or |
T2484 |
1312-1315 |
DT |
denotes |
the |
T2486 |
1316-1321 |
NN |
denotes |
PPARδ |
T2487 |
1322-1329 |
NN |
denotes |
agonist |
T2485 |
1330-1338 |
NN |
denotes |
GW501516 |
T2488 |
1339-1342 |
IN |
denotes |
for |
T2489 |
1343-1344 |
CD |
denotes |
2 |
T2490 |
1345-1347 |
NN |
denotes |
mo |
T2491 |
1347-1348 |
. |
denotes |
. |
T2492 |
1348-1620 |
sentence |
denotes |
GW501516 produced a sustained induction of genes for type I muscle fibers; this, at least in part, resulted in an only 30% gain in body weight, a dramatically reduced fat mass accumulation, and improved glucose tolerance, compared to the vehicle-treated group (Figure 5). |
T2493 |
1349-1357 |
NN |
denotes |
GW501516 |
T2494 |
1358-1366 |
VBD |
denotes |
produced |
T2496 |
1367-1368 |
DT |
denotes |
a |
T2498 |
1369-1378 |
VBN |
denotes |
sustained |
T2497 |
1379-1388 |
NN |
denotes |
induction |
T2499 |
1389-1391 |
IN |
denotes |
of |
T2500 |
1392-1397 |
NNS |
denotes |
genes |
T2501 |
1398-1401 |
IN |
denotes |
for |
T2502 |
1402-1406 |
NN |
denotes |
type |
T2504 |
1407-1408 |
CD |
denotes |
I |
T2505 |
1409-1415 |
NN |
denotes |
muscle |
T2503 |
1416-1422 |
NNS |
denotes |
fibers |
T2506 |
1422-1423 |
: |
denotes |
; |
T2507 |
1424-1428 |
DT |
denotes |
this |
T2508 |
1428-1430 |
, |
denotes |
, |
T2509 |
1430-1432 |
RB |
denotes |
at |
T2510 |
1433-1438 |
RBS |
denotes |
least |
T2511 |
1439-1441 |
IN |
denotes |
in |
T2512 |
1442-1446 |
JJ |
denotes |
part |
T2513 |
1446-1448 |
, |
denotes |
, |
T2495 |
1448-1456 |
VBD |
denotes |
resulted |
T2514 |
1457-1459 |
IN |
denotes |
in |
T2515 |
1460-1462 |
DT |
denotes |
an |
T2517 |
1463-1467 |
RB |
denotes |
only |
T2518 |
1468-1470 |
CD |
denotes |
30 |
T2519 |
1470-1471 |
NN |
denotes |
% |
T2516 |
1472-1476 |
NN |
denotes |
gain |
T2520 |
1477-1479 |
IN |
denotes |
in |
T2521 |
1480-1484 |
NN |
denotes |
body |
T2522 |
1485-1491 |
NN |
denotes |
weight |
T2523 |
1491-1493 |
, |
denotes |
, |
T2524 |
1493-1494 |
DT |
denotes |
a |
T2526 |
1495-1507 |
RB |
denotes |
dramatically |
T2527 |
1508-1515 |
VBN |
denotes |
reduced |
T2528 |
1516-1519 |
NN |
denotes |
fat |
T2529 |
1520-1524 |
NN |
denotes |
mass |
T2525 |
1525-1537 |
NN |
denotes |
accumulation |
T2530 |
1537-1539 |
, |
denotes |
, |
T2531 |
1539-1542 |
CC |
denotes |
and |
T2532 |
1543-1551 |
VBN |
denotes |
improved |
T2534 |
1552-1559 |
NN |
denotes |
glucose |
T2533 |
1560-1569 |
NN |
denotes |
tolerance |
T2535 |
1569-1571 |
, |
denotes |
, |
T2536 |
1571-1579 |
VBN |
denotes |
compared |
T2537 |
1580-1582 |
IN |
denotes |
to |
T2538 |
1583-1586 |
DT |
denotes |
the |
T2540 |
1587-1594 |
NN |
denotes |
vehicle |
T2542 |
1594-1595 |
HYPH |
denotes |
- |
T2541 |
1595-1602 |
VBN |
denotes |
treated |
T2539 |
1603-1608 |
NN |
denotes |
group |
T2543 |
1609-1610 |
-LRB- |
denotes |
( |
T2544 |
1610-1616 |
NN |
denotes |
Figure |
T2545 |
1617-1618 |
CD |
denotes |
5 |
T2546 |
1618-1619 |
-RRB- |
denotes |
) |
T2547 |
1619-1620 |
. |
denotes |
. |
T2548 |
1620-1754 |
sentence |
denotes |
Thus, muscle fiber conversion by stimulation with the PPARδ agonist or the activated transgene has a protective role against obesity. |
T2549 |
1621-1625 |
RB |
denotes |
Thus |
T2551 |
1625-1627 |
, |
denotes |
, |
T2552 |
1627-1633 |
NN |
denotes |
muscle |
T2553 |
1634-1639 |
NN |
denotes |
fiber |
T2554 |
1640-1650 |
NN |
denotes |
conversion |
T2555 |
1651-1653 |
IN |
denotes |
by |
T2556 |
1654-1665 |
NN |
denotes |
stimulation |
T2557 |
1666-1670 |
IN |
denotes |
with |
T2558 |
1671-1674 |
DT |
denotes |
the |
T2560 |
1675-1680 |
NN |
denotes |
PPARδ |
T2559 |
1681-1688 |
NN |
denotes |
agonist |
T2561 |
1689-1691 |
CC |
denotes |
or |
T2562 |
1692-1695 |
DT |
denotes |
the |
T2564 |
1696-1705 |
VBN |
denotes |
activated |
T2563 |
1706-1715 |
NN |
denotes |
transgene |
T2550 |
1716-1719 |
VBZ |
denotes |
has |
T2565 |
1720-1721 |
DT |
denotes |
a |
T2567 |
1722-1732 |
JJ |
denotes |
protective |
T2566 |
1733-1737 |
NN |
denotes |
role |
T2568 |
1738-1745 |
IN |
denotes |
against |
T2569 |
1746-1753 |
NN |
denotes |
obesity |
T2570 |
1753-1754 |
. |
denotes |
. |
R1524 |
T2224 |
T2225 |
det |
A,number |
R1525 |
T2225 |
T2226 |
nsubj |
number,shown |
R1526 |
T2227 |
T2225 |
prep |
of,number |
R1527 |
T2228 |
T2229 |
amod |
previous,studies |
R1528 |
T2229 |
T2227 |
pobj |
studies,of |
R1529 |
T2230 |
T2226 |
aux |
have,shown |
R1530 |
T2231 |
T2232 |
mark |
that,have |
R1531 |
T2232 |
T2226 |
ccomp |
have,shown |
R1532 |
T2233 |
T2234 |
amod |
obese,individuals |
R1533 |
T2234 |
T2232 |
nsubj |
individuals,have |
R1534 |
T2235 |
T2236 |
amod |
fewer,fibers |
R1535 |
T2236 |
T2232 |
dobj |
fibers,have |
R1536 |
T2237 |
T2236 |
amod |
oxidative,fibers |
R1537 |
T2238 |
T2232 |
punct |
", ",have |
R1538 |
T2239 |
T2232 |
advcl |
implying,have |
R1539 |
T2240 |
T2241 |
mark |
that,play |
R1540 |
T2241 |
T2239 |
ccomp |
play,implying |
R1541 |
T2242 |
T2243 |
det |
the,presence |
R1542 |
T2243 |
T2241 |
nsubj |
presence,play |
R1543 |
T2244 |
T2243 |
prep |
of,presence |
R1544 |
T2245 |
T2246 |
amod |
oxidative,fibers |
R1545 |
T2246 |
T2244 |
pobj |
fibers,of |
R1546 |
T2247 |
T2243 |
advmod |
alone,presence |
R1547 |
T2248 |
T2241 |
aux |
may,play |
R1548 |
T2249 |
T2250 |
det |
a,part |
R1549 |
T2250 |
T2241 |
dobj |
part,play |
R1550 |
T2251 |
T2241 |
prep |
in,play |
R1551 |
T2252 |
T2253 |
compound |
obesity,resistance |
R1552 |
T2253 |
T2251 |
pobj |
resistance,in |
R1553 |
T2254 |
T2226 |
punct |
.,shown |
R1554 |
T2256 |
T2257 |
aux |
To,test |
R1555 |
T2257 |
T2258 |
advcl |
test,fed |
R1556 |
T2259 |
T2260 |
det |
this,possibility |
R1557 |
T2260 |
T2257 |
dobj |
possibility,test |
R1558 |
T2261 |
T2258 |
punct |
", ",fed |
R1559 |
T2262 |
T2258 |
nsubj |
we,fed |
R1560 |
T2263 |
T2264 |
det |
the,mice |
R1561 |
T2264 |
T2258 |
dobj |
mice,fed |
R1562 |
T2265 |
T2264 |
amod |
transgenic,mice |
R1563 |
T2266 |
T2264 |
cc |
and,mice |
R1564 |
T2267 |
T2268 |
poss |
their,littermates |
R1565 |
T2268 |
T2264 |
conj |
littermates,mice |
R1566 |
T2269 |
T2270 |
amod |
wild,type |
R1567 |
T2270 |
T2268 |
compound |
type,littermates |
R1568 |
T2271 |
T2270 |
punct |
-,type |
R1569 |
T2272 |
T2258 |
prep |
with,fed |
R1570 |
T2273 |
T2274 |
det |
a,diet |
R1571 |
T2274 |
T2272 |
pobj |
diet,with |
R1572 |
T2275 |
T2276 |
amod |
high,fat |
R1573 |
T2276 |
T2274 |
compound |
fat,diet |
R1574 |
T2277 |
T2276 |
punct |
-,fat |
R1575 |
T2278 |
T2258 |
prep |
for,fed |
R1576 |
T2279 |
T2280 |
nummod |
97,d |
R1577 |
T2280 |
T2278 |
pobj |
d,for |
R1578 |
T2281 |
T2258 |
punct |
.,fed |
R1579 |
T2283 |
T2284 |
mark |
Although,were |
R1580 |
T2284 |
T2293 |
advcl |
were,gained |
R1581 |
T2285 |
T2286 |
det |
the,weights |
R1582 |
T2286 |
T2284 |
nsubj |
weights,were |
R1583 |
T2287 |
T2286 |
amod |
initial,weights |
R1584 |
T2288 |
T2286 |
compound |
body,weights |
R1585 |
T2289 |
T2286 |
prep |
of,weights |
R1586 |
T2290 |
T2291 |
det |
the,groups |
R1587 |
T2291 |
T2289 |
pobj |
groups,of |
R1588 |
T2292 |
T2291 |
nummod |
two,groups |
R1589 |
T2294 |
T2295 |
advmod |
very,similar |
R1590 |
T2295 |
T2284 |
acomp |
similar,were |
R1591 |
T2296 |
T2293 |
punct |
", ",gained |
R1592 |
T2297 |
T2298 |
det |
the,mice |
R1593 |
T2298 |
T2293 |
nsubj |
mice,gained |
R1594 |
T2299 |
T2298 |
amod |
transgenic,mice |
R1595 |
T2300 |
T2293 |
aux |
had,gained |
R1596 |
T2301 |
T2302 |
amod |
less,50 |
R1597 |
T2302 |
T2304 |
nummod |
50,% |
R1598 |
T2303 |
T2302 |
quantmod |
than,50 |
R1599 |
T2304 |
T2293 |
dobj |
%,gained |
R1600 |
T2305 |
T2293 |
prep |
at,gained |
R1601 |
T2306 |
T2305 |
pobj |
day,at |
R1602 |
T2307 |
T2306 |
nummod |
47,day |
R1603 |
T2308 |
T2293 |
punct |
", ",gained |
R1604 |
T2309 |
T2293 |
cc |
and,gained |
R1605 |
T2310 |
T2311 |
advmod |
only,third |
R1606 |
T2311 |
T2293 |
conj |
third,gained |
R1607 |
T2312 |
T2311 |
advmod |
one,third |
R1608 |
T2313 |
T2311 |
punct |
-,third |
R1609 |
T2314 |
T2311 |
prep |
at,third |
R1610 |
T2315 |
T2314 |
pobj |
day,at |
R1611 |
T2316 |
T2315 |
nummod |
97,day |
R1612 |
T2317 |
T2311 |
punct |
", ",third |
R1613 |
T2318 |
T2311 |
conj |
of,third |
R1614 |
T2319 |
T2320 |
det |
the,weight |
R1615 |
T2320 |
T2318 |
pobj |
weight,of |
R1616 |
T2321 |
T2320 |
acl |
gained,weight |
R1617 |
T2322 |
T2321 |
agent |
by,gained |
R1618 |
T2323 |
T2324 |
det |
the,animals |
R1619 |
T2324 |
T2322 |
pobj |
animals,by |
R1620 |
T2325 |
T2326 |
amod |
wild,type |
R1621 |
T2326 |
T2324 |
compound |
type,animals |
R1622 |
T2327 |
T2326 |
punct |
-,type |
R1623 |
T2328 |
T2329 |
punct |
(,Figure |
R1624 |
T2329 |
T2318 |
parataxis |
Figure,of |
R1625 |
T2330 |
T2329 |
nummod |
4A,Figure |
R1626 |
T2331 |
T2329 |
punct |
),Figure |
R1627 |
T2332 |
T2293 |
punct |
.,gained |
R1628 |
T2334 |
T2335 |
det |
The,mice |
R1629 |
T2335 |
T2337 |
nsubj |
mice,displayed |
R1630 |
T2336 |
T2335 |
amod |
transgenic,mice |
R1631 |
T2338 |
T2339 |
advmod |
significantly,higher |
R1632 |
T2339 |
T2340 |
amod |
higher,consumption |
R1633 |
T2340 |
T2337 |
dobj |
consumption,displayed |
R1634 |
T2341 |
T2340 |
compound |
oxygen,consumption |
R1635 |
T2342 |
T2340 |
prep |
on,consumption |
R1636 |
T2343 |
T2344 |
det |
the,diet |
R1637 |
T2344 |
T2342 |
pobj |
diet,on |
R1638 |
T2345 |
T2346 |
amod |
high,fat |
R1639 |
T2346 |
T2344 |
compound |
fat,diet |
R1640 |
T2347 |
T2346 |
punct |
-,fat |
R1641 |
T2348 |
T2340 |
prep |
than,consumption |
R1642 |
T2349 |
T2350 |
det |
the,littermates |
R1643 |
T2350 |
T2348 |
pobj |
littermates,than |
R1644 |
T2351 |
T2350 |
compound |
control,littermates |
R1645 |
T2352 |
T2353 |
punct |
(,data |
R1646 |
T2353 |
T2337 |
parataxis |
data,displayed |
R1647 |
T2354 |
T2353 |
amod |
unpublished,data |
R1648 |
T2355 |
T2353 |
punct |
),data |
R1649 |
T2356 |
T2337 |
punct |
.,displayed |
R1650 |
T2358 |
T2359 |
prep |
By,became |
R1651 |
T2360 |
T2361 |
det |
the,end |
R1652 |
T2361 |
T2358 |
pobj |
end,By |
R1653 |
T2362 |
T2361 |
prep |
of,end |
R1654 |
T2363 |
T2364 |
det |
this,experiment |
R1655 |
T2364 |
T2362 |
pobj |
experiment,of |
R1656 |
T2365 |
T2359 |
punct |
", ",became |
R1657 |
T2366 |
T2367 |
det |
the,littermates |
R1658 |
T2367 |
T2359 |
nsubj |
littermates,became |
R1659 |
T2368 |
T2367 |
compound |
control,littermates |
R1660 |
T2369 |
T2359 |
attr |
obese,became |
R1661 |
T2370 |
T2359 |
punct |
", ",became |
R1662 |
T2371 |
T2372 |
mark |
whereas,maintained |
R1663 |
T2372 |
T2359 |
advcl |
maintained,became |
R1664 |
T2373 |
T2374 |
det |
the,mice |
R1665 |
T2374 |
T2372 |
nsubj |
mice,maintained |
R1666 |
T2375 |
T2374 |
amod |
transgenic,mice |
R1667 |
T2376 |
T2372 |
advmod |
still,maintained |
R1668 |
T2377 |
T2378 |
det |
a,weight |
R1669 |
T2378 |
T2372 |
dobj |
weight,maintained |
R1670 |
T2379 |
T2378 |
amod |
normal,weight |
R1671 |
T2380 |
T2378 |
compound |
body,weight |
R1672 |
T2381 |
T2378 |
cc |
and,weight |
R1673 |
T2382 |
T2383 |
compound |
fat,mass |
R1674 |
T2383 |
T2384 |
compound |
mass,composition |
R1675 |
T2384 |
T2378 |
conj |
composition,weight |
R1676 |
T2385 |
T2386 |
punct |
(,Figure |
R1677 |
T2386 |
T2372 |
parataxis |
Figure,maintained |
R1678 |
T2387 |
T2386 |
nummod |
4A,Figure |
R1679 |
T2388 |
T2386 |
punct |
),Figure |
R1680 |
T2389 |
T2359 |
punct |
.,became |
R1681 |
T2391 |
T2392 |
det |
A,analysis |
R1682 |
T2392 |
T2394 |
nsubj |
analysis,revealed |
R1683 |
T2393 |
T2392 |
amod |
histological,analysis |
R1684 |
T2395 |
T2392 |
prep |
of,analysis |
R1685 |
T2396 |
T2397 |
amod |
inguinal,pad |
R1686 |
T2397 |
T2395 |
pobj |
pad,of |
R1687 |
T2398 |
T2397 |
compound |
fat,pad |
R1688 |
T2399 |
T2400 |
det |
a,size |
R1689 |
T2400 |
T2394 |
dobj |
size,revealed |
R1690 |
T2401 |
T2402 |
advmod |
much,smaller |
R1691 |
T2402 |
T2400 |
amod |
smaller,size |
R1692 |
T2403 |
T2400 |
compound |
cell,size |
R1693 |
T2404 |
T2394 |
prep |
in,revealed |
R1694 |
T2405 |
T2406 |
det |
the,mice |
R1695 |
T2406 |
T2404 |
pobj |
mice,in |
R1696 |
T2407 |
T2406 |
amod |
transgenic,mice |
R1697 |
T2408 |
T2409 |
punct |
(,Figure |
R1698 |
T2409 |
T2394 |
parataxis |
Figure,revealed |
R1699 |
T2410 |
T2409 |
nummod |
4B,Figure |
R1700 |
T2411 |
T2409 |
punct |
),Figure |
R1701 |
T2412 |
T2394 |
punct |
", ",revealed |
R1702 |
T2413 |
T2394 |
prep |
due,revealed |
R1703 |
T2414 |
T2413 |
pcomp |
to,due |
R1704 |
T2415 |
T2416 |
det |
the,capacity |
R1705 |
T2416 |
T2413 |
pobj |
capacity,due |
R1706 |
T2417 |
T2416 |
amod |
increased,capacity |
R1707 |
T2418 |
T2416 |
nmod |
muscle,capacity |
R1708 |
T2419 |
T2416 |
amod |
oxidative,capacity |
R1709 |
T2420 |
T2394 |
punct |
.,revealed |
R1710 |
T2422 |
T2423 |
mark |
While,was |
R1711 |
T2423 |
T2425 |
advcl |
was,was |
R1712 |
T2424 |
T2423 |
expl |
there,was |
R1713 |
T2426 |
T2427 |
det |
no,difference |
R1714 |
T2427 |
T2423 |
attr |
difference,was |
R1715 |
T2428 |
T2427 |
amod |
significant,difference |
R1716 |
T2429 |
T2427 |
prep |
in,difference |
R1717 |
T2430 |
T2431 |
amod |
intramuscular,content |
R1718 |
T2431 |
T2429 |
pobj |
content,in |
R1719 |
T2432 |
T2431 |
compound |
glycogen,content |
R1720 |
T2433 |
T2425 |
punct |
", ",was |
R1721 |
T2434 |
T2435 |
det |
the,content |
R1722 |
T2435 |
T2425 |
nsubj |
content,was |
R1723 |
T2436 |
T2435 |
compound |
triglyceride,content |
R1724 |
T2437 |
T2438 |
advmod |
much,less |
R1725 |
T2438 |
T2425 |
acomp |
less,was |
R1726 |
T2439 |
T2425 |
prep |
in,was |
R1727 |
T2440 |
T2441 |
det |
the,mice |
R1728 |
T2441 |
T2439 |
pobj |
mice,in |
R1729 |
T2442 |
T2441 |
amod |
transgenic,mice |
R1730 |
T2443 |
T2444 |
punct |
(,Figure |
R1731 |
T2444 |
T2425 |
parataxis |
Figure,was |
R1732 |
T2445 |
T2444 |
nummod |
4C,Figure |
R1733 |
T2446 |
T2444 |
cc |
and,Figure |
R1734 |
T2447 |
T2444 |
conj |
4D,Figure |
R1735 |
T2448 |
T2444 |
punct |
),Figure |
R1736 |
T2449 |
T2425 |
punct |
", ",was |
R1737 |
T2450 |
T2451 |
dep |
which,explain |
R1738 |
T2451 |
T2425 |
advcl |
explain,was |
R1739 |
T2452 |
T2451 |
aux |
may,explain |
R1740 |
T2453 |
T2454 |
poss |
their,tolerance |
R1741 |
T2454 |
T2451 |
dobj |
tolerance,explain |
R1742 |
T2455 |
T2454 |
amod |
improved,tolerance |
R1743 |
T2456 |
T2454 |
compound |
glucose,tolerance |
R1744 |
T2457 |
T2458 |
punct |
(,Figure |
R1745 |
T2458 |
T2451 |
parataxis |
Figure,explain |
R1746 |
T2459 |
T2458 |
nummod |
4E,Figure |
R1747 |
T2460 |
T2458 |
punct |
),Figure |
R1748 |
T2461 |
T2425 |
punct |
.,was |
R1749 |
T2463 |
T2464 |
nsubj |
We,placed |
R1750 |
T2465 |
T2464 |
advmod |
also,placed |
R1751 |
T2466 |
T2467 |
amod |
wild,type |
R1752 |
T2467 |
T2469 |
compound |
type,mice |
R1753 |
T2468 |
T2467 |
punct |
-,type |
R1754 |
T2469 |
T2464 |
dobj |
mice,placed |
R1755 |
T2470 |
T2469 |
compound |
C57BJ6,mice |
R1756 |
T2471 |
T2464 |
prep |
on,placed |
R1757 |
T2472 |
T2473 |
det |
the,diet |
R1758 |
T2473 |
T2471 |
pobj |
diet,on |
R1759 |
T2474 |
T2475 |
amod |
high,fat |
R1760 |
T2475 |
T2473 |
compound |
fat,diet |
R1761 |
T2476 |
T2475 |
punct |
-,fat |
R1762 |
T2477 |
T2464 |
cc |
and,placed |
R1763 |
T2478 |
T2464 |
conj |
treated,placed |
R1764 |
T2479 |
T2478 |
dobj |
them,treated |
R1765 |
T2480 |
T2478 |
prep |
with,treated |
R1766 |
T2481 |
T2482 |
preconj |
either,vehicle |
R1767 |
T2482 |
T2480 |
pobj |
vehicle,with |
R1768 |
T2483 |
T2482 |
cc |
or,vehicle |
R1769 |
T2484 |
T2485 |
det |
the,GW501516 |
R1770 |
T2485 |
T2482 |
conj |
GW501516,vehicle |
R1771 |
T2486 |
T2487 |
compound |
PPARδ,agonist |
R1772 |
T2487 |
T2485 |
compound |
agonist,GW501516 |
R1773 |
T2488 |
T2478 |
prep |
for,treated |
R1774 |
T2489 |
T2490 |
nummod |
2,mo |
R1775 |
T2490 |
T2488 |
pobj |
mo,for |
R1776 |
T2491 |
T2464 |
punct |
.,placed |
R1777 |
T2493 |
T2494 |
nsubj |
GW501516,produced |
R1778 |
T2494 |
T2495 |
ccomp |
produced,resulted |
R1779 |
T2496 |
T2497 |
det |
a,induction |
R1780 |
T2497 |
T2494 |
dobj |
induction,produced |
R1781 |
T2498 |
T2497 |
amod |
sustained,induction |
R1782 |
T2499 |
T2497 |
prep |
of,induction |
R1783 |
T2500 |
T2499 |
pobj |
genes,of |
R1784 |
T2501 |
T2500 |
prep |
for,genes |
R1785 |
T2502 |
T2503 |
nmod |
type,fibers |
R1786 |
T2503 |
T2501 |
pobj |
fibers,for |
R1787 |
T2504 |
T2502 |
nummod |
I,type |
R1788 |
T2505 |
T2503 |
compound |
muscle,fibers |
R1789 |
T2506 |
T2495 |
punct |
;,resulted |
R1790 |
T2507 |
T2495 |
nsubj |
this,resulted |
R1791 |
T2508 |
T2495 |
punct |
", ",resulted |
R1792 |
T2509 |
T2510 |
advmod |
at,least |
R1793 |
T2510 |
T2511 |
advmod |
least,in |
R1794 |
T2511 |
T2495 |
prep |
in,resulted |
R1795 |
T2512 |
T2511 |
amod |
part,in |
R1796 |
T2513 |
T2495 |
punct |
", ",resulted |
R1797 |
T2514 |
T2495 |
prep |
in,resulted |
R1798 |
T2515 |
T2516 |
det |
an,gain |
R1799 |
T2516 |
T2514 |
pobj |
gain,in |
R1800 |
T2517 |
T2518 |
advmod |
only,30 |
R1801 |
T2518 |
T2519 |
nummod |
30,% |
R1802 |
T2519 |
T2516 |
compound |
%,gain |
R1803 |
T2520 |
T2516 |
prep |
in,gain |
R1804 |
T2521 |
T2522 |
compound |
body,weight |
R1805 |
T2522 |
T2520 |
pobj |
weight,in |
R1806 |
T2523 |
T2516 |
punct |
", ",gain |
R1807 |
T2524 |
T2525 |
det |
a,accumulation |
R1808 |
T2525 |
T2516 |
conj |
accumulation,gain |
R1809 |
T2526 |
T2527 |
advmod |
dramatically,reduced |
R1810 |
T2527 |
T2525 |
amod |
reduced,accumulation |
R1811 |
T2528 |
T2529 |
compound |
fat,mass |
R1812 |
T2529 |
T2525 |
compound |
mass,accumulation |
R1813 |
T2530 |
T2525 |
punct |
", ",accumulation |
R1814 |
T2531 |
T2525 |
cc |
and,accumulation |
R1815 |
T2532 |
T2533 |
amod |
improved,tolerance |
R1816 |
T2533 |
T2525 |
conj |
tolerance,accumulation |
R1817 |
T2534 |
T2533 |
compound |
glucose,tolerance |
R1818 |
T2535 |
T2516 |
punct |
", ",gain |
R1819 |
T2536 |
T2516 |
prep |
compared,gain |
R1820 |
T2537 |
T2536 |
prep |
to,compared |
R1821 |
T2538 |
T2539 |
det |
the,group |
R1822 |
T2539 |
T2537 |
pobj |
group,to |
R1823 |
T2540 |
T2541 |
npadvmod |
vehicle,treated |
R1824 |
T2541 |
T2539 |
amod |
treated,group |
R1825 |
T2542 |
T2541 |
punct |
-,treated |
R1826 |
T2543 |
T2544 |
punct |
(,Figure |
R1827 |
T2544 |
T2495 |
parataxis |
Figure,resulted |
R1828 |
T2545 |
T2544 |
nummod |
5,Figure |
R1829 |
T2546 |
T2544 |
punct |
),Figure |
R1830 |
T2547 |
T2495 |
punct |
.,resulted |
R1831 |
T2549 |
T2550 |
advmod |
Thus,has |
R1832 |
T2551 |
T2550 |
punct |
", ",has |
R1833 |
T2552 |
T2553 |
compound |
muscle,fiber |
R1834 |
T2553 |
T2554 |
compound |
fiber,conversion |
R1835 |
T2554 |
T2550 |
nsubj |
conversion,has |
R1836 |
T2555 |
T2554 |
prep |
by,conversion |
R1837 |
T2556 |
T2555 |
pobj |
stimulation,by |
R1838 |
T2557 |
T2556 |
prep |
with,stimulation |
R1839 |
T2558 |
T2559 |
det |
the,agonist |
R1840 |
T2559 |
T2557 |
pobj |
agonist,with |
R1841 |
T2560 |
T2559 |
compound |
PPARδ,agonist |
R1842 |
T2561 |
T2559 |
cc |
or,agonist |
R1843 |
T2562 |
T2563 |
det |
the,transgene |
R1844 |
T2563 |
T2559 |
conj |
transgene,agonist |
R1845 |
T2564 |
T2563 |
amod |
activated,transgene |
R1846 |
T2565 |
T2566 |
det |
a,role |
R1847 |
T2566 |
T2550 |
dobj |
role,has |
R1848 |
T2567 |
T2566 |
amod |
protective,role |
R1849 |
T2568 |
T2566 |
prep |
against,role |
R1850 |
T2569 |
T2568 |
pobj |
obesity,against |
R1851 |
T2570 |
T2550 |
punct |
.,has |