PMC:509410 JSON TXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id	Subject	Object	Predicate	Lexical cue
T61	0-10	NN	denotes	Regulation
T62	0-62	sentence	denotes	Regulation of Muscle Fiber Type and Running Endurance by PPARδ
T63	11-13	IN	denotes	of
T64	14-20	NN	denotes	Muscle
T65	21-26	NN	denotes	Fiber
T66	27-31	NN	denotes	Type
T67	32-35	CC	denotes	and
T68	36-43	NN	denotes	Running
T69	44-53	NN	denotes	Endurance
T70	54-56	IN	denotes	by
T71	57-62	NN	denotes	PPARδ
T72	62-63	sentence	denotes
T74	116-125	NN	denotes	Endurance
T73	116-290	sentence	denotes	Endurance exercise training can promote an adaptive muscle fiber transformation and an increase of mitochondrial biogenesis by triggering scripted changes in gene expression.
T76	126-134	NN	denotes	exercise
T75	135-143	NN	denotes	training
T78	144-147	MD	denotes	can
T77	148-155	VB	denotes	promote
T79	156-158	DT	denotes	an
T81	159-167	JJ	denotes	adaptive
T82	168-174	NN	denotes	muscle
T83	175-180	NN	denotes	fiber
T80	181-195	NN	denotes	transformation
T84	196-199	CC	denotes	and
T85	200-202	DT	denotes	an
T86	203-211	NN	denotes	increase
T87	212-214	IN	denotes	of
T88	215-228	JJ	denotes	mitochondrial
T89	229-239	NN	denotes	biogenesis
T90	240-242	IN	denotes	by
T91	243-253	VBG	denotes	triggering
T92	254-262	VBN	denotes	scripted
T93	263-270	NNS	denotes	changes
T94	271-273	IN	denotes	in
T95	274-278	NN	denotes	gene
T96	279-289	NN	denotes	expression
T97	289-290	.	denotes	.
T98	290-377	sentence	denotes	However, no transcription factor has yet been identified that can direct this process.
T99	291-298	RB	denotes	However
T101	298-300	,	denotes	,
T102	300-302	DT	denotes	no
T104	303-316	NN	denotes	transcription
T103	317-323	NN	denotes	factor
T105	324-327	VBZ	denotes	has
T106	328-331	RB	denotes	yet
T107	332-336	VBN	denotes	been
T100	337-347	VBN	denotes	identified
T108	348-352	WDT	denotes	that
T110	353-356	MD	denotes	can
T109	357-363	VB	denotes	direct
T111	364-368	DT	denotes	this
T112	369-376	NN	denotes	process
T113	376-377	.	denotes	.
T114	377-501	sentence	denotes	We describe the engineering of a mouse capable of continuous running of up to twice the distance of a wild-type littermate.
T115	378-380	PRP	denotes	We
T116	381-389	VBP	denotes	describe
T117	390-393	DT	denotes	the
T118	394-405	NN	denotes	engineering
T119	406-408	IN	denotes	of
T120	409-410	DT	denotes	a
T121	411-416	NN	denotes	mouse
T122	417-424	JJ	denotes	capable
T123	425-427	IN	denotes	of
T124	428-438	JJ	denotes	continuous
T125	439-446	NN	denotes	running
T126	447-449	IN	denotes	of
T127	450-452	RB	denotes	up
T129	453-455	IN	denotes	to
T128	456-461	RB	denotes	twice
T131	462-465	DT	denotes	the
T130	466-474	NN	denotes	distance
T132	475-477	IN	denotes	of
T133	478-479	DT	denotes	a
T135	480-484	JJ	denotes	wild
T137	484-485	HYPH	denotes	-
T136	485-489	NN	denotes	type
T134	490-500	NN	denotes	littermate
T138	500-501	.	denotes	.
T139	501-713	sentence	denotes	This was achieved by targeted expression of an activated form of peroxisome proliferator-activated receptor δ (PPARδ) in skeletal muscle, which induces a switch to form increased numbers of type I muscle fibers.
T140	502-506	DT	denotes	This
T142	507-510	VBD	denotes	was
T141	511-519	VBN	denotes	achieved
T143	520-522	IN	denotes	by
T144	523-531	JJ	denotes	targeted
T145	532-542	NN	denotes	expression
T146	543-545	IN	denotes	of
T147	546-548	DT	denotes	an
T149	549-558	JJ	denotes	activated
T148	559-563	NN	denotes	form
T150	564-566	IN	denotes	of
T151	567-577	NN	denotes	peroxisome
T152	578-590	NN	denotes	proliferator
T154	590-591	HYPH	denotes	-
T153	591-600	VBN	denotes	activated
T155	601-609	NN	denotes	receptor
T156	610-611	SYM	denotes	δ
T157	612-613	-LRB-	denotes	(
T158	613-618	NN	denotes	PPARδ
T159	618-619	-RRB-	denotes	)
T160	620-622	IN	denotes	in
T161	623-631	JJ	denotes	skeletal
T162	632-638	NN	denotes	muscle
T163	638-640	,	denotes	,
T164	640-645	WDT	denotes	which
T165	646-653	VBZ	denotes	induces
T166	654-655	DT	denotes	a
T167	656-662	NN	denotes	switch
T168	663-665	TO	denotes	to
T169	666-670	VB	denotes	form
T170	671-680	VBN	denotes	increased
T171	681-688	NNS	denotes	numbers
T172	689-691	IN	denotes	of
T173	692-696	NN	denotes	type
T175	697-698	CD	denotes	I
T176	699-705	NN	denotes	muscle
T174	706-712	NNS	denotes	fibers
T177	712-713	.	denotes	.
T178	713-826	sentence	denotes	Treatment of wild-type mice with PPARδ agonist elicits a similar type I fiber gene expression profile in muscle.
T179	714-723	NN	denotes	Treatment
T181	724-726	IN	denotes	of
T182	727-731	JJ	denotes	wild
T184	731-732	HYPH	denotes	-
T183	732-736	NN	denotes	type
T185	737-741	NNS	denotes	mice
T186	742-746	IN	denotes	with
T187	747-752	NN	denotes	PPARδ
T188	753-760	NN	denotes	agonist
T180	761-768	VBZ	denotes	elicits
T189	769-770	DT	denotes	a
T191	771-778	JJ	denotes	similar
T192	779-783	NN	denotes	type
T194	784-785	CD	denotes	I
T193	786-791	NN	denotes	fiber
T195	792-796	NN	denotes	gene
T196	797-807	NN	denotes	expression
T190	808-815	NN	denotes	profile
T197	816-818	IN	denotes	in
T198	819-825	NN	denotes	muscle
T199	825-826	.	denotes	.
T200	826-967	sentence	denotes	Moreover, these genetically generated fibers confer resistance to obesity with improved metabolic profiles, even in the absence of exercise.
T201	827-835	RB	denotes	Moreover
T203	835-837	,	denotes	,
T204	837-842	DT	denotes	these
T206	843-854	RB	denotes	genetically
T207	855-864	VBN	denotes	generated
T205	865-871	NNS	denotes	fibers
T202	872-878	VBP	denotes	confer
T208	879-889	NN	denotes	resistance
T209	890-892	IN	denotes	to
T210	893-900	NN	denotes	obesity
T211	901-905	IN	denotes	with
T212	906-914	VBN	denotes	improved
T214	915-924	JJ	denotes	metabolic
T213	925-933	NNS	denotes	profiles
T215	933-935	,	denotes	,
T216	935-939	RB	denotes	even
T217	940-942	IN	denotes	in
T218	943-946	DT	denotes	the
T219	947-954	NN	denotes	absence
T220	955-957	IN	denotes	of
T221	958-966	NN	denotes	exercise
T222	966-967	.	denotes	.
T223	967-1123	sentence	denotes	These results demonstrate that complex physiologic properties such as fatigue, endurance, and running capacity can be molecularly analyzed and manipulated.
T224	968-973	DT	denotes	These
T225	974-981	NNS	denotes	results
T226	982-993	VBP	denotes	demonstrate
T227	994-998	IN	denotes	that
T229	999-1006	JJ	denotes	complex
T231	1007-1018	JJ	denotes	physiologic
T230	1019-1029	NNS	denotes	properties
T232	1030-1034	JJ	denotes	such
T233	1035-1037	IN	denotes	as
T234	1038-1045	NN	denotes	fatigue
T235	1045-1047	,	denotes	,
T236	1047-1056	NN	denotes	endurance
T237	1056-1058	,	denotes	,
T238	1058-1061	CC	denotes	and
T239	1062-1069	NN	denotes	running
T240	1070-1078	NN	denotes	capacity
T241	1079-1082	MD	denotes	can
T242	1083-1085	VB	denotes	be
T243	1086-1097	RB	denotes	molecularly
T228	1098-1106	VBN	denotes	analyzed
T244	1107-1110	CC	denotes	and
T245	1111-1122	VBN	denotes	manipulated
T246	1122-1123	.	denotes	.
T425	1341-1349	JJ	denotes	Skeletal
T427	1350-1356	NN	denotes	muscle
T426	1357-1363	NNS	denotes	fibers
T429	1364-1367	VBP	denotes	are
T430	1368-1377	RB	denotes	generally
T428	1378-1388	VBN	denotes	classified
T431	1389-1391	IN	denotes	as
T432	1392-1396	NN	denotes	type
T434	1397-1398	CD	denotes	I
T435	1399-1400	-LRB-	denotes	(
T437	1400-1409	JJ	denotes	oxidative
T438	1409-1410	HYPH	denotes	/
T436	1410-1414	JJ	denotes	slow
T439	1414-1415	-RRB-	denotes	)
T440	1416-1418	CC	denotes	or
T441	1419-1423	NN	denotes	type
T442	1424-1426	CD	denotes	II
T443	1427-1428	-LRB-	denotes	(
T445	1428-1438	JJ	denotes	glycolytic
T446	1438-1439	HYPH	denotes	/
T444	1439-1443	JJ	denotes	fast
T447	1443-1444	-RRB-	denotes	)
T433	1445-1451	NNS	denotes	fibers
T448	1451-1452	.	denotes	.
T449	1452-1554	sentence	denotes	They display marked differences in respect to contraction, metabolism, and susceptibility to fatigue.
T450	1453-1457	PRP	denotes	They
T451	1458-1465	VBP	denotes	display
T452	1466-1472	JJ	denotes	marked
T453	1473-1484	NNS	denotes	differences
T454	1485-1487	IN	denotes	in
T455	1488-1495	NN	denotes	respect
T456	1496-1498	IN	denotes	to
T457	1499-1510	NN	denotes	contraction
T458	1510-1512	,	denotes	,
T459	1512-1522	NN	denotes	metabolism
T460	1522-1524	,	denotes	,
T461	1524-1527	CC	denotes	and
T462	1528-1542	NN	denotes	susceptibility
T463	1543-1545	IN	denotes	to
T464	1546-1553	NN	denotes	fatigue
T465	1553-1554	.	denotes	.
T466	1554-1737	sentence	denotes	Type I fibers are mitochondria-rich and mainly use oxidative metabolism for energy production, which provides a stable and long-lasting supply of ATP, and thus are fatigue-resistant.
T467	1555-1559	NN	denotes	Type
T469	1560-1561	CD	denotes	I
T468	1562-1568	NNS	denotes	fibers
T470	1569-1572	VBP	denotes	are
T471	1573-1585	NNS	denotes	mitochondria
T473	1585-1586	HYPH	denotes	-
T472	1586-1590	JJ	denotes	rich
T474	1591-1594	CC	denotes	and
T475	1595-1601	RB	denotes	mainly
T476	1602-1605	VBP	denotes	use
T477	1606-1615	JJ	denotes	oxidative
T478	1616-1626	NN	denotes	metabolism
T479	1627-1630	IN	denotes	for
T480	1631-1637	NN	denotes	energy
T481	1638-1648	NN	denotes	production
T482	1648-1650	,	denotes	,
T483	1650-1655	WDT	denotes	which
T484	1656-1664	VBZ	denotes	provides
T485	1665-1666	DT	denotes	a
T487	1667-1673	JJ	denotes	stable
T488	1674-1677	CC	denotes	and
T489	1678-1682	JJ	denotes	long
T491	1682-1683	HYPH	denotes	-
T490	1683-1690	VBG	denotes	lasting
T486	1691-1697	NN	denotes	supply
T492	1698-1700	IN	denotes	of
T493	1701-1704	NN	denotes	ATP
T494	1704-1706	,	denotes	,
T495	1706-1709	CC	denotes	and
T496	1710-1714	RB	denotes	thus
T497	1715-1718	VBP	denotes	are
T498	1719-1726	NN	denotes	fatigue
T500	1726-1727	HYPH	denotes	-
T499	1727-1736	JJ	denotes	resistant
T501	1736-1737	.	denotes	.
T502	1737-1796	sentence	denotes	Type II fibers comprise three subtypes, IIa, IIx, and IIb.
T503	1738-1742	NN	denotes	Type
T505	1743-1745	CD	denotes	II
T504	1746-1752	NNS	denotes	fibers
T506	1753-1761	VBP	denotes	comprise
T507	1762-1767	CD	denotes	three
T508	1768-1776	NNS	denotes	subtypes
T509	1776-1778	,	denotes	,
T510	1778-1781	NN	denotes	IIa
T511	1781-1783	,	denotes	,
T512	1783-1786	NN	denotes	IIx
T513	1786-1788	,	denotes	,
T514	1788-1791	CC	denotes	and
T515	1792-1795	NN	denotes	IIb
T516	1795-1796	.	denotes	.
T517	1796-2139	sentence	denotes	Type IIb fibers have the lowest levels of mitochondrial content and oxidative enzymes, rely on glycolytic metabolism as a major energy source, and are susceptible to fatigue, while the oxidative and contraction functions of type IIa and IIx lie between type I and IIb (Booth and Thomason 1991; Berchtold et al. 2000; Olson and Williams 2000).
T518	1797-1801	NN	denotes	Type
T519	1802-1805	NN	denotes	IIb
T520	1806-1812	NNS	denotes	fibers
T521	1813-1817	VBP	denotes	have
T522	1818-1821	DT	denotes	the
T524	1822-1828	JJS	denotes	lowest
T523	1829-1835	NNS	denotes	levels
T525	1836-1838	IN	denotes	of
T526	1839-1852	JJ	denotes	mitochondrial
T527	1853-1860	NN	denotes	content
T528	1861-1864	CC	denotes	and
T529	1865-1874	JJ	denotes	oxidative
T530	1875-1882	NNS	denotes	enzymes
T531	1882-1884	,	denotes	,
T532	1884-1888	VBP	denotes	rely
T533	1889-1891	IN	denotes	on
T534	1892-1902	JJ	denotes	glycolytic
T535	1903-1913	NN	denotes	metabolism
T536	1914-1916	IN	denotes	as
T537	1917-1918	DT	denotes	a
T539	1919-1924	JJ	denotes	major
T540	1925-1931	NN	denotes	energy
T538	1932-1938	NN	denotes	source
T541	1938-1940	,	denotes	,
T542	1940-1943	CC	denotes	and
T543	1944-1947	VBP	denotes	are
T544	1948-1959	JJ	denotes	susceptible
T545	1960-1962	IN	denotes	to
T546	1963-1970	NN	denotes	fatigue
T547	1970-1972	,	denotes	,
T548	1972-1977	IN	denotes	while
T550	1978-1981	DT	denotes	the
T552	1982-1991	JJ	denotes	oxidative
T553	1992-1995	CC	denotes	and
T554	1996-2007	NN	denotes	contraction
T551	2008-2017	NNS	denotes	functions
T555	2018-2020	IN	denotes	of
T556	2021-2025	NN	denotes	type
T557	2026-2029	NN	denotes	IIa
T558	2030-2033	CC	denotes	and
T559	2034-2037	NN	denotes	IIx
T549	2038-2041	VBP	denotes	lie
T560	2042-2049	IN	denotes	between
T561	2050-2054	NN	denotes	type
T563	2055-2056	CD	denotes	I
T564	2057-2060	CC	denotes	and
T562	2061-2064	NN	denotes	IIb
T565	2065-2066	-LRB-	denotes	(
T566	2066-2071	NNP	denotes	Booth
T567	2072-2075	CC	denotes	and
T568	2076-2084	NNP	denotes	Thomason
T569	2085-2089	CD	denotes	1991
T570	2089-2090	:	denotes	;
T571	2091-2100	NNP	denotes	Berchtold
T572	2101-2103	FW	denotes	et
T573	2104-2107	FW	denotes	al.
T574	2108-2112	CD	denotes	2000
T575	2112-2113	:	denotes	;
T576	2114-2119	NNP	denotes	Olson
T577	2120-2123	CC	denotes	and
T578	2124-2132	NNP	denotes	Williams
T579	2133-2137	CD	denotes	2000
T580	2137-2138	-RRB-	denotes	)
T581	2138-2139	.	denotes	.
T582	2139-2400	sentence	denotes	Adult skeletal muscle shows plasticity and can undergo conversion between different fiber types in response to exercise training or modulation of motoneuron activity (Booth and Thomason 1991, Jarvis et al. 1996; Pette 1998; Olson and Williams 2000; Hood 2001).
T583	2140-2145	JJ	denotes	Adult
T585	2146-2154	JJ	denotes	skeletal
T584	2155-2161	NN	denotes	muscle
T586	2162-2167	VBZ	denotes	shows
T587	2168-2178	NN	denotes	plasticity
T588	2179-2182	CC	denotes	and
T589	2183-2186	MD	denotes	can
T590	2187-2194	VB	denotes	undergo
T591	2195-2205	NN	denotes	conversion
T592	2206-2213	IN	denotes	between
T593	2214-2223	JJ	denotes	different
T595	2224-2229	NN	denotes	fiber
T594	2230-2235	NNS	denotes	types
T596	2236-2238	IN	denotes	in
T597	2239-2247	NN	denotes	response
T598	2248-2250	IN	denotes	to
T599	2251-2259	NN	denotes	exercise
T600	2260-2268	NN	denotes	training
T601	2269-2271	CC	denotes	or
T602	2272-2282	NN	denotes	modulation
T603	2283-2285	IN	denotes	of
T604	2286-2296	NN	denotes	motoneuron
T605	2297-2305	NN	denotes	activity
T606	2306-2307	-LRB-	denotes	(
T607	2307-2312	NNP	denotes	Booth
T608	2313-2316	CC	denotes	and
T609	2317-2325	NNP	denotes	Thomason
T610	2326-2330	CD	denotes	1991
T611	2330-2332	,	denotes	,
T612	2332-2338	NNP	denotes	Jarvis
T613	2339-2341	FW	denotes	et
T614	2342-2345	FW	denotes	al.
T615	2346-2350	CD	denotes	1996
T616	2350-2351	:	denotes	;
T617	2352-2357	NNP	denotes	Pette
T618	2358-2362	CD	denotes	1998
T619	2362-2363	:	denotes	;
T620	2364-2369	NNP	denotes	Olson
T621	2370-2373	CC	denotes	and
T622	2374-2382	NNP	denotes	Williams
T623	2383-2387	CD	denotes	2000
T624	2387-2388	:	denotes	;
T625	2389-2393	NNP	denotes	Hood
T626	2394-2398	CD	denotes	2001
T627	2398-2399	-RRB-	denotes	)
T628	2399-2400	.	denotes	.
T629	2400-2765	sentence	denotes	This conversion of muscle fiber from type IIb to type IIa and type I is likely to be mediated by a calcium signaling pathway that involves calcineurin, calmodulin-dependent kinase, and the transcriptional cofactor Peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) (Naya et al. 2000; Olson and Williams 2000; Lin et al. 2002; Wu et al. 2002).
T630	2401-2405	DT	denotes	This
T631	2406-2416	NN	denotes	conversion
T633	2417-2419	IN	denotes	of
T634	2420-2426	NN	denotes	muscle
T635	2427-2432	NN	denotes	fiber
T636	2433-2437	IN	denotes	from
T637	2438-2442	NN	denotes	type
T638	2443-2446	NN	denotes	IIb
T639	2447-2449	IN	denotes	to
T640	2450-2454	NN	denotes	type
T641	2455-2458	NN	denotes	IIa
T642	2459-2462	CC	denotes	and
T643	2463-2467	NN	denotes	type
T644	2468-2469	CD	denotes	I
T632	2470-2472	VBZ	denotes	is
T645	2473-2479	JJ	denotes	likely
T646	2480-2482	TO	denotes	to
T648	2483-2485	VB	denotes	be
T647	2486-2494	VBN	denotes	mediated
T649	2495-2497	IN	denotes	by
T650	2498-2499	DT	denotes	a
T652	2500-2507	NN	denotes	calcium
T653	2508-2517	NN	denotes	signaling
T651	2518-2525	NN	denotes	pathway
T654	2526-2530	WDT	denotes	that
T655	2531-2539	VBZ	denotes	involves
T656	2540-2551	NN	denotes	calcineurin
T657	2551-2553	,	denotes	,
T658	2553-2563	NN	denotes	calmodulin
T660	2563-2564	HYPH	denotes	-
T659	2564-2573	JJ	denotes	dependent
T661	2574-2580	NN	denotes	kinase
T662	2580-2582	,	denotes	,
T663	2582-2585	CC	denotes	and
T664	2586-2589	DT	denotes	the
T666	2590-2605	JJ	denotes	transcriptional
T665	2606-2614	NN	denotes	cofactor
T667	2615-2625	NN	denotes	Peroxisome
T668	2626-2638	NN	denotes	proliferator
T670	2638-2639	HYPH	denotes	-
T669	2639-2648	VBN	denotes	activated
T671	2649-2657	NN	denotes	receptor
T673	2657-2658	HYPH	denotes	-
T674	2658-2663	NN	denotes	gamma
T672	2664-2675	NN	denotes	coactivator
T675	2676-2678	CD	denotes	1α
T676	2679-2680	-LRB-	denotes	(
T677	2680-2683	NN	denotes	PGC
T679	2683-2684	HYPH	denotes	-
T678	2684-2686	NN	denotes	1α
T680	2686-2687	-RRB-	denotes	)
T681	2688-2689	-LRB-	denotes	(
T682	2689-2693	NNP	denotes	Naya
T683	2694-2696	FW	denotes	et
T684	2697-2700	FW	denotes	al.
T685	2701-2705	CD	denotes	2000
T686	2705-2706	:	denotes	;
T687	2707-2712	NNP	denotes	Olson
T688	2713-2716	CC	denotes	and
T689	2717-2725	NNP	denotes	Williams
T690	2726-2730	CD	denotes	2000
T691	2730-2731	:	denotes	;
T692	2732-2735	NNP	denotes	Lin
T693	2736-2738	FW	denotes	et
T694	2739-2742	FW	denotes	al.
T695	2743-2747	CD	denotes	2002
T696	2747-2748	:	denotes	;
T697	2749-2751	NNP	denotes	Wu
T698	2752-2754	FW	denotes	et
T699	2755-2758	FW	denotes	al.
T700	2759-2763	CD	denotes	2002
T701	2763-2764	-RRB-	denotes	)
T702	2764-2765	.	denotes	.
T703	2765-2926	sentence	denotes	However, the targeted transcriptional factors directly responsible for reprogramming the fiber-specific contractile and metabolic genes remain to be identified.
T704	2766-2773	RB	denotes	However
T706	2773-2775	,	denotes	,
T707	2775-2778	DT	denotes	the
T709	2779-2787	VBN	denotes	targeted
T710	2788-2803	JJ	denotes	transcriptional
T708	2804-2811	NNS	denotes	factors
T711	2812-2820	RB	denotes	directly
T712	2821-2832	JJ	denotes	responsible
T713	2833-2836	IN	denotes	for
T714	2837-2850	VBG	denotes	reprogramming
T715	2851-2854	DT	denotes	the
T717	2855-2860	NN	denotes	fiber
T719	2860-2861	HYPH	denotes	-
T718	2861-2869	JJ	denotes	specific
T720	2870-2881	JJ	denotes	contractile
T721	2882-2885	CC	denotes	and
T722	2886-2895	JJ	denotes	metabolic
T716	2896-2901	NNS	denotes	genes
T705	2902-2908	VBP	denotes	remain
T723	2909-2911	TO	denotes	to
T725	2912-2914	VB	denotes	be
T724	2915-2925	VBN	denotes	identified
T726	2925-2926	.	denotes	.
T727	2926-3005	sentence	denotes	Muscle fiber specification appears to be associated with obesity and diabetes.
T728	2927-2933	NN	denotes	Muscle
T730	2934-2939	NN	denotes	fiber
T729	2940-2953	NN	denotes	specification
T731	2954-2961	VBZ	denotes	appears
T732	2962-2964	TO	denotes	to
T734	2965-2967	VB	denotes	be
T733	2968-2978	VBN	denotes	associated
T735	2979-2983	IN	denotes	with
T736	2984-2991	NN	denotes	obesity
T737	2992-2995	CC	denotes	and
T738	2996-3004	NN	denotes	diabetes
T739	3004-3005	.	denotes	.
T740	3005-3119	sentence	denotes	For instance, rodents that gain the most weight on high-fat diets possess fewer type I fibers (Abou et al. 1992).
T741	3006-3009	IN	denotes	For
T743	3010-3018	NN	denotes	instance
T744	3018-3020	,	denotes	,
T745	3020-3027	NNS	denotes	rodents
T746	3028-3032	WDT	denotes	that
T747	3033-3037	VBP	denotes	gain
T748	3038-3041	DT	denotes	the
T750	3042-3046	JJS	denotes	most
T749	3047-3053	NN	denotes	weight
T751	3054-3056	IN	denotes	on
T752	3057-3061	JJ	denotes	high
T754	3061-3062	HYPH	denotes	-
T753	3062-3065	NN	denotes	fat
T755	3066-3071	NNS	denotes	diets
T742	3072-3079	VBP	denotes	possess
T756	3080-3085	JJR	denotes	fewer
T758	3086-3090	NN	denotes	type
T759	3091-3092	CD	denotes	I
T757	3093-3099	NNS	denotes	fibers
T760	3100-3101	-LRB-	denotes	(
T761	3101-3105	NNP	denotes	Abou
T762	3106-3108	FW	denotes	et
T763	3109-3112	FW	denotes	al.
T764	3113-3117	CD	denotes	1992
T765	3117-3118	-RRB-	denotes	)
T766	3118-3119	.	denotes	.
T767	3119-3325	sentence	denotes	In obese patients, skeletal muscle has been observed to have reduced oxidative capacity, increased glycolytic capacity, and a decreased percentage of type I fibers (Hickey et al. 1995; Tanner et al. 2002).
T768	3120-3122	IN	denotes	In
T770	3123-3128	JJ	denotes	obese
T771	3129-3137	NNS	denotes	patients
T772	3137-3139	,	denotes	,
T773	3139-3147	JJ	denotes	skeletal
T774	3148-3154	NN	denotes	muscle
T775	3155-3158	VBZ	denotes	has
T776	3159-3163	VBN	denotes	been
T769	3164-3172	VBN	denotes	observed
T777	3173-3175	TO	denotes	to
T778	3176-3180	VB	denotes	have
T779	3181-3188	VBN	denotes	reduced
T781	3189-3198	JJ	denotes	oxidative
T780	3199-3207	NN	denotes	capacity
T782	3207-3209	,	denotes	,
T783	3209-3218	VBN	denotes	increased
T785	3219-3229	JJ	denotes	glycolytic
T784	3230-3238	NN	denotes	capacity
T786	3238-3240	,	denotes	,
T787	3240-3243	CC	denotes	and
T788	3244-3245	DT	denotes	a
T790	3246-3255	VBN	denotes	decreased
T789	3256-3266	NN	denotes	percentage
T791	3267-3269	IN	denotes	of
T792	3270-3274	NN	denotes	type
T794	3275-3276	CD	denotes	I
T793	3277-3283	NNS	denotes	fibers
T795	3284-3285	-LRB-	denotes	(
T796	3285-3291	NNP	denotes	Hickey
T797	3292-3294	FW	denotes	et
T798	3295-3298	FW	denotes	al.
T799	3299-3303	CD	denotes	1995
T800	3303-3304	:	denotes	;
T801	3305-3311	NNP	denotes	Tanner
T802	3312-3314	FW	denotes	et
T803	3315-3318	FW	denotes	al.
T804	3319-3323	CD	denotes	2002
T805	3323-3324	-RRB-	denotes	)
T806	3324-3325	.	denotes	.
T807	3325-3433	sentence	denotes	Similar observations have been made in type 2 diabetic patients (Lillioja et al. 1987; Hickey et al. 1995).
T808	3326-3333	JJ	denotes	Similar
T809	3334-3346	NNS	denotes	observations
T811	3347-3351	VBP	denotes	have
T812	3352-3356	VBN	denotes	been
T810	3357-3361	VBN	denotes	made
T813	3362-3364	IN	denotes	in
T814	3365-3369	NN	denotes	type
T816	3370-3371	CD	denotes	2
T815	3372-3380	JJ	denotes	diabetic
T817	3381-3389	NNS	denotes	patients
T818	3390-3391	-LRB-	denotes	(
T819	3391-3399	NNP	denotes	Lillioja
T820	3400-3402	FW	denotes	et
T821	3403-3406	FW	denotes	al.
T822	3407-3411	CD	denotes	1987
T823	3411-3412	:	denotes	;
T824	3413-3419	NNP	denotes	Hickey
T825	3420-3422	FW	denotes	et
T826	3423-3426	FW	denotes	al.
T827	3427-3431	CD	denotes	1995
T828	3431-3432	-RRB-	denotes	)
T829	3432-3433	.	denotes	.
T830	3433-3598	sentence	denotes	Recently, it has been shown that increasing oxidative fibers can lead to improved insulin action and reduced adipocyte size (Luquet et al. 2003; Ryder et al. 2003).
T831	3434-3442	RB	denotes	Recently
T833	3442-3444	,	denotes	,
T834	3444-3446	PRP	denotes	it
T835	3447-3450	VBZ	denotes	has
T836	3451-3455	VBN	denotes	been
T832	3456-3461	VBN	denotes	shown
T837	3462-3466	IN	denotes	that
T839	3467-3477	VBG	denotes	increasing
T841	3478-3487	JJ	denotes	oxidative
T840	3488-3494	NNS	denotes	fibers
T842	3495-3498	MD	denotes	can
T838	3499-3503	VB	denotes	lead
T843	3504-3506	IN	denotes	to
T844	3507-3515	VBN	denotes	improved
T846	3516-3523	NN	denotes	insulin
T845	3524-3530	NN	denotes	action
T847	3531-3534	CC	denotes	and
T848	3535-3542	VBN	denotes	reduced
T850	3543-3552	NN	denotes	adipocyte
T849	3553-3557	NN	denotes	size
T851	3558-3559	-LRB-	denotes	(
T852	3559-3565	NNP	denotes	Luquet
T853	3566-3568	FW	denotes	et
T854	3569-3572	FW	denotes	al.
T855	3573-3577	CD	denotes	2003
T856	3577-3578	:	denotes	;
T857	3579-3584	NNP	denotes	Ryder
T858	3585-3587	FW	denotes	et
T859	3588-3591	FW	denotes	al.
T860	3592-3596	CD	denotes	2003
T861	3596-3597	-RRB-	denotes	)
T862	3597-3598	.	denotes	.
T863	3598-3856	sentence	denotes	We have previously established that peroxisome proliferator-activated receptor (PPAR) δ is a major transcriptional regulator of fat burning in adipose tissue through activation of enzymes associated with long-chain fatty-acid β-oxidation (Wang et al. 2003).
T864	3599-3601	PRP	denotes	We
T866	3602-3606	VBP	denotes	have
T867	3607-3617	RB	denotes	previously
T865	3618-3629	VBN	denotes	established
T868	3630-3634	IN	denotes	that
T870	3635-3645	NN	denotes	peroxisome
T871	3646-3658	NN	denotes	proliferator
T873	3658-3659	HYPH	denotes	-
T872	3659-3668	VBN	denotes	activated
T874	3669-3677	NN	denotes	receptor
T875	3678-3679	-LRB-	denotes	(
T876	3679-3683	NN	denotes	PPAR
T877	3683-3684	-RRB-	denotes	)
T878	3685-3686	SYM	denotes	δ
T869	3687-3689	VBZ	denotes	is
T879	3690-3691	DT	denotes	a
T881	3692-3697	JJ	denotes	major
T882	3698-3713	JJ	denotes	transcriptional
T880	3714-3723	NN	denotes	regulator
T883	3724-3726	IN	denotes	of
T884	3727-3730	NN	denotes	fat
T885	3731-3738	NN	denotes	burning
T886	3739-3741	IN	denotes	in
T887	3742-3749	NN	denotes	adipose
T888	3750-3756	NN	denotes	tissue
T889	3757-3764	IN	denotes	through
T890	3765-3775	NN	denotes	activation
T891	3776-3778	IN	denotes	of
T892	3779-3786	NNS	denotes	enzymes
T893	3787-3797	VBN	denotes	associated
T894	3798-3802	IN	denotes	with
T895	3803-3807	JJ	denotes	long
T897	3807-3808	HYPH	denotes	-
T896	3808-3813	NN	denotes	chain
T899	3814-3819	JJ	denotes	fatty
T901	3819-3820	HYPH	denotes	-
T900	3820-3824	NN	denotes	acid
T902	3825-3826	NN	denotes	β
T903	3826-3827	HYPH	denotes	-
T898	3827-3836	NN	denotes	oxidation
T904	3837-3838	-LRB-	denotes	(
T905	3838-3842	NNP	denotes	Wang
T906	3843-3845	FW	denotes	et
T907	3846-3849	FW	denotes	al.
T908	3850-3854	CD	denotes	2003
T909	3854-3855	-RRB-	denotes	)
T910	3855-3856	.	denotes	.
T911	3856-3977	sentence	denotes	Although PPARδ is the predominant PPAR isoform present in skeletal muscle, its in vivo function has not been determined.
T912	3857-3865	IN	denotes	Although
T914	3866-3871	NN	denotes	PPARδ
T913	3872-3874	VBZ	denotes	is
T916	3875-3878	DT	denotes	the
T918	3879-3890	JJ	denotes	predominant
T919	3891-3895	NN	denotes	PPAR
T917	3896-3903	NN	denotes	isoform
T920	3904-3911	JJ	denotes	present
T921	3912-3914	IN	denotes	in
T922	3915-3923	JJ	denotes	skeletal
T923	3924-3930	NN	denotes	muscle
T924	3930-3932	,	denotes	,
T925	3932-3935	PRP$	denotes	its
T927	3936-3938	FW	denotes	in
T928	3939-3943	FW	denotes	vivo
T926	3944-3952	NN	denotes	function
T929	3953-3956	VBZ	denotes	has
T930	3957-3960	RB	denotes	not
T931	3961-3965	VBN	denotes	been
T915	3966-3976	VBN	denotes	determined
T932	3976-3977	.	denotes	.
T933	3977-4231	sentence	denotes	Our current study uncovers PPARδ as the first transcription factor able to drive the formation of functional type I muscle fibers, whose activation entrains complex pathways both enhancing physical performance and creating a state of obesity resistance.
T934	3978-3981	PRP$	denotes	Our
T936	3982-3989	JJ	denotes	current
T935	3990-3995	NN	denotes	study
T937	3996-4004	VBZ	denotes	uncovers
T938	4005-4010	NN	denotes	PPARδ
T939	4011-4013	IN	denotes	as
T940	4014-4017	DT	denotes	the
T942	4018-4023	JJ	denotes	first
T943	4024-4037	NN	denotes	transcription
T941	4038-4044	NN	denotes	factor
T944	4045-4049	JJ	denotes	able
T945	4050-4052	TO	denotes	to
T946	4053-4058	VB	denotes	drive
T947	4059-4062	DT	denotes	the
T948	4063-4072	NN	denotes	formation
T949	4073-4075	IN	denotes	of
T950	4076-4086	JJ	denotes	functional
T952	4087-4091	NN	denotes	type
T953	4092-4093	CD	denotes	I
T954	4094-4100	NN	denotes	muscle
T951	4101-4107	NNS	denotes	fibers
T955	4107-4109	,	denotes	,
T956	4109-4114	WP$	denotes	whose
T957	4115-4125	NN	denotes	activation
T958	4126-4134	VBZ	denotes	entrains
T959	4135-4142	JJ	denotes	complex
T960	4143-4151	NNS	denotes	pathways
T961	4152-4156	CC	denotes	both
T962	4157-4166	VBG	denotes	enhancing
T963	4167-4175	JJ	denotes	physical
T964	4176-4187	NN	denotes	performance
T965	4188-4191	CC	denotes	and
T966	4192-4200	VBG	denotes	creating
T967	4201-4202	DT	denotes	a
T968	4203-4208	NN	denotes	state
T969	4209-4211	IN	denotes	of
T970	4212-4219	NN	denotes	obesity
T971	4220-4230	NN	denotes	resistance
T972	4230-4231	.	denotes	.
T1279	4242-4252	NN	denotes	Activation
T1281	4253-4255	IN	denotes	of
T1282	4256-4261	NN	denotes	PPARδ
T1280	4262-4267	VBZ	denotes	Leads
T1283	4268-4270	IN	denotes	to
T1284	4271-4277	NN	denotes	Muscle
T1285	4278-4283	NN	denotes	Fiber
T1286	4284-4298	NN	denotes	Transformation
T1287	4298-4469	sentence	denotes	A role of PPARδ in muscle fiber was suggested by its enhanced expression—at levels 10-fold and 50-fold greater than PPARα and γ isoforms, respectively (unpublished data).
T1288	4299-4300	DT	denotes	A
T1289	4301-4305	NN	denotes	role
T1291	4306-4308	IN	denotes	of
T1292	4309-4314	NN	denotes	PPARδ
T1293	4315-4317	IN	denotes	in
T1294	4318-4324	NN	denotes	muscle
T1295	4325-4330	NN	denotes	fiber
T1296	4331-4334	VBD	denotes	was
T1290	4335-4344	VBN	denotes	suggested
T1297	4345-4347	IN	denotes	by
T1298	4348-4351	PRP$	denotes	its
T1300	4352-4360	VBN	denotes	enhanced
T1299	4361-4371	NN	denotes	expression
T1301	4371-4372	HYPH	denotes	—
T1302	4372-4374	IN	denotes	at
T1303	4375-4381	NNS	denotes	levels
T1304	4382-4384	CD	denotes	10
T1306	4384-4385	HYPH	denotes	-
T1307	4385-4389	RB	denotes	fold
T1308	4390-4393	CC	denotes	and
T1309	4394-4396	CD	denotes	50
T1310	4396-4397	HYPH	denotes	-
T1311	4397-4401	RB	denotes	fold
T1305	4402-4409	JJR	denotes	greater
T1312	4410-4414	IN	denotes	than
T1313	4415-4420	NN	denotes	PPARα
T1315	4421-4424	CC	denotes	and
T1316	4425-4426	SYM	denotes	γ
T1314	4427-4435	NNS	denotes	isoforms
T1317	4435-4437	,	denotes	,
T1318	4437-4449	RB	denotes	respectively
T1319	4450-4451	-LRB-	denotes	(
T1321	4451-4462	JJ	denotes	unpublished
T1320	4463-4467	NNS	denotes	data
T1322	4467-4468	-RRB-	denotes	)
T1323	4468-4469	.	denotes	.
T1324	4469-4783	sentence	denotes	An examination of PPARδ in different muscle fibers reveals a significantly higher level in type I muscle (soleus) relative to type II–rich muscle (extensor digitorum longus) or type I and type II mixed muscle (gastrocnemius) (Figure 1A); this expression pattern closely resembles that of PGC-1α (Lin et al. 2002).
T1325	4470-4472	DT	denotes	An
T1326	4473-4484	NN	denotes	examination
T1328	4485-4487	IN	denotes	of
T1329	4488-4493	NN	denotes	PPARδ
T1330	4494-4496	IN	denotes	in
T1331	4497-4506	JJ	denotes	different
T1333	4507-4513	NN	denotes	muscle
T1332	4514-4520	NNS	denotes	fibers
T1327	4521-4528	VBZ	denotes	reveals
T1335	4529-4530	DT	denotes	a
T1337	4531-4544	RB	denotes	significantly
T1338	4545-4551	JJR	denotes	higher
T1336	4552-4557	NN	denotes	level
T1339	4558-4560	IN	denotes	in
T1340	4561-4565	NN	denotes	type
T1342	4566-4567	CD	denotes	I
T1341	4568-4574	NN	denotes	muscle
T1343	4575-4576	-LRB-	denotes	(
T1344	4576-4582	NN	denotes	soleus
T1345	4582-4583	-RRB-	denotes	)
T1346	4584-4592	JJ	denotes	relative
T1347	4593-4595	IN	denotes	to
T1348	4596-4600	NN	denotes	type
T1350	4601-4603	CD	denotes	II
T1351	4603-4604	HYPH	denotes	–
T1349	4604-4608	JJ	denotes	rich
T1352	4609-4615	NN	denotes	muscle
T1353	4616-4617	-LRB-	denotes	(
T1355	4617-4625	NN	denotes	extensor
T1356	4626-4635	NN	denotes	digitorum
T1354	4636-4642	NN	denotes	longus
T1357	4642-4643	-RRB-	denotes	)
T1358	4644-4646	CC	denotes	or
T1359	4647-4651	NN	denotes	type
T1361	4652-4653	CD	denotes	I
T1362	4654-4657	CC	denotes	and
T1363	4658-4662	NN	denotes	type
T1364	4663-4665	CD	denotes	II
T1365	4666-4671	JJ	denotes	mixed
T1360	4672-4678	NN	denotes	muscle
T1366	4679-4680	-LRB-	denotes	(
T1367	4680-4693	NN	denotes	gastrocnemius
T1368	4693-4694	-RRB-	denotes	)
T1369	4695-4696	-LRB-	denotes	(
T1370	4696-4702	NN	denotes	Figure
T1371	4703-4705	CD	denotes	1A
T1372	4705-4706	-RRB-	denotes	)
T1373	4706-4707	,	denotes	;
T1374	4708-4712	DT	denotes	this
T1376	4713-4723	NN	denotes	expression
T1375	4724-4731	NN	denotes	pattern
T1377	4732-4739	RB	denotes	closely
T1334	4740-4749	VBZ	denotes	resembles
T1378	4750-4754	DT	denotes	that
T1379	4755-4757	IN	denotes	of
T1380	4758-4761	NN	denotes	PGC
T1381	4761-4762	HYPH	denotes	-
T1382	4762-4764	CD	denotes	1α
T1383	4765-4766	-LRB-	denotes	(
T1384	4766-4769	NNP	denotes	Lin
T1385	4770-4772	FW	denotes	et
T1386	4773-4776	FW	denotes	al.
T1387	4777-4781	CD	denotes	2002
T1388	4781-4782	-RRB-	denotes	)
T1389	4782-4783	.	denotes	.
T1390	4783-4882	sentence	denotes	A similar pattern but with more pronounced differences was found at the protein level (Figure 1B).
T1391	4784-4785	DT	denotes	A
T1393	4786-4793	JJ	denotes	similar
T1392	4794-4801	NN	denotes	pattern
T1395	4802-4805	CC	denotes	but
T1396	4806-4810	IN	denotes	with
T1397	4811-4815	RBR	denotes	more
T1398	4816-4826	VBN	denotes	pronounced
T1399	4827-4838	NNS	denotes	differences
T1400	4839-4842	VBD	denotes	was
T1394	4843-4848	VBN	denotes	found
T1401	4849-4851	IN	denotes	at
T1402	4852-4855	DT	denotes	the
T1404	4856-4863	NN	denotes	protein
T1403	4864-4869	NN	denotes	level
T1405	4870-4871	-LRB-	denotes	(
T1406	4871-4877	NN	denotes	Figure
T1407	4878-4880	CD	denotes	1B
T1408	4880-4881	-RRB-	denotes	)
T1409	4881-4882	.	denotes	.
T1410	4882-6086	sentence	denotes	Figure 1 Expression of Endogenous PPARδ and VP16-PPARδ Transgene in Muscle (A) Pooled RNA isolated from various muscles of five wild-type male C57B6 mice was hybridized with indicated probes. EDL, extensor digitorum longus; Gastro, gastrocnemius. (B) Pooled nuclear proteins (15 μg/lane) isolated from muscles of five wild-type male C57B6 were probed with anti-PPARδ antibody. RNA polymerase II (Pol II) is shown as a loading control. (C) Expression of the VP16-PPARδ transgene in various tissues. 10 μg of total RNA from each tissue was hybridized with a VP16 cDNA probe. Gastrocnemius muscle was used here. (D) Nuclear proteins (15 μg/lane) isolated from gastrocnemius muscle of the transgenic mice (TG) and the wild-type littermates (WT) were probed with indicated antibodies. The upper, nonspecific band that cross-reacted with the anti-PPARδ antibody serves a loading control. To directly assess the role of activation of PPARδ in control of muscle fiber plasticity and mitochondrial biogenesis, we generated mice expressing a transgene in which the 78-amino-acid VP16 activation domain was fused to the N-terminus of full-length PPARδ, under control of the 2.2-kb human α-skeletal actin promoter.
T4687	4893-4903	NN	denotes	Expression
T4688	4904-4906	IN	denotes	of
T4689	4907-4917	JJ	denotes	Endogenous
T4691	4918-4923	NN	denotes	PPARδ
T4692	4924-4927	CC	denotes	and
T4693	4928-4932	NN	denotes	VP16
T4695	4932-4933	HYPH	denotes	-
T4694	4933-4938	NN	denotes	PPARδ
T4690	4939-4948	NN	denotes	Transgene
T4696	4949-4951	IN	denotes	in
T4697	4952-4958	NN	denotes	Muscle
T4698	4958-5075	sentence	denotes	(A) Pooled RNA isolated from various muscles of five wild-type male C57B6 mice was hybridized with indicated probes.
T4699	4959-4960	-LRB-	denotes	(
T4700	4960-4961	LS	denotes	A
T4702	4961-4962	-RRB-	denotes	)
T4703	4963-4969	VBN	denotes	Pooled
T4704	4970-4973	NN	denotes	RNA
T4705	4974-4982	VBN	denotes	isolated
T4706	4983-4987	IN	denotes	from
T4707	4988-4995	JJ	denotes	various
T4708	4996-5003	NNS	denotes	muscles
T4709	5004-5006	IN	denotes	of
T4710	5007-5011	CD	denotes	five
T4712	5012-5016	JJ	denotes	wild
T4714	5016-5017	HYPH	denotes	-
T4713	5017-5021	NN	denotes	type
T4715	5022-5026	JJ	denotes	male
T4716	5027-5032	NN	denotes	C57B6
T4711	5033-5037	NNS	denotes	mice
T4717	5038-5041	VBD	denotes	was
T4701	5042-5052	VBN	denotes	hybridized
T4718	5053-5057	IN	denotes	with
T4719	5058-5067	VBN	denotes	indicated
T4720	5068-5074	NNS	denotes	probes
T4721	5074-5075	.	denotes	.
T4722	5075-5130	sentence	denotes	EDL, extensor digitorum longus; Gastro, gastrocnemius.
T4723	5076-5079	NN	denotes	EDL
T4724	5079-5081	,	denotes	,
T4725	5081-5089	NN	denotes	extensor
T4727	5090-5099	NN	denotes	digitorum
T4726	5100-5106	NN	denotes	longus
T4728	5106-5107	,	denotes	;
T4729	5108-5114	NN	denotes	Gastro
T4730	5114-5116	,	denotes	,
T4731	5116-5129	NN	denotes	gastrocnemius
T4732	5129-5130	.	denotes	.
T4733	5130-5260	sentence	denotes	(B) Pooled nuclear proteins (15 μg/lane) isolated from muscles of five wild-type male C57B6 were probed with anti-PPARδ antibody.
T4734	5131-5132	-LRB-	denotes	(
T4735	5132-5133	LS	denotes	B
T4737	5133-5134	-RRB-	denotes	)
T4738	5135-5141	VBN	denotes	Pooled
T4740	5142-5149	JJ	denotes	nuclear
T4739	5150-5158	NN	denotes	proteins
T4741	5159-5160	-LRB-	denotes	(
T4743	5160-5162	CD	denotes	15
T4742	5163-5165	NNS	denotes	μg
T4744	5165-5166	SYM	denotes	/
T4745	5166-5170	NN	denotes	lane
T4746	5170-5171	-RRB-	denotes	)
T4747	5172-5180	VBN	denotes	isolated
T4748	5181-5185	IN	denotes	from
T4749	5186-5193	NNS	denotes	muscles
T4750	5194-5196	IN	denotes	of
T4751	5197-5201	CD	denotes	five
T4753	5202-5206	JJ	denotes	wild
T4755	5206-5207	HYPH	denotes	-
T4754	5207-5211	NN	denotes	type
T4756	5212-5216	JJ	denotes	male
T4752	5217-5222	NN	denotes	C57B6
T4757	5223-5227	VBD	denotes	were
T4736	5228-5234	VBN	denotes	probed
T4758	5235-5239	IN	denotes	with
T4759	5240-5250	JJ	denotes	anti-PPARδ
T4760	5251-5259	NN	denotes	antibody
T4761	5259-5260	.	denotes	.
T4762	5260-5318	sentence	denotes	RNA polymerase II (Pol II) is shown as a loading control.
T4763	5261-5264	NN	denotes	RNA
T4764	5265-5275	NN	denotes	polymerase
T4766	5276-5278	CD	denotes	II
T4767	5279-5280	-LRB-	denotes	(
T4768	5280-5283	NN	denotes	Pol
T4769	5284-5286	CD	denotes	II
T4770	5286-5287	-RRB-	denotes	)
T4771	5288-5290	VBZ	denotes	is
T4765	5291-5296	VBN	denotes	shown
T4772	5297-5299	IN	denotes	as
T4773	5300-5301	DT	denotes	a
T4775	5302-5309	NN	denotes	loading
T4774	5310-5317	NN	denotes	control
T4776	5317-5318	.	denotes	.
T4777	5318-5381	sentence	denotes	(C) Expression of the VP16-PPARδ transgene in various tissues.
T4778	5319-5320	-LRB-	denotes	(
T4779	5320-5321	LS	denotes	C
T4781	5321-5322	-RRB-	denotes	)
T4780	5323-5333	NN	denotes	Expression
T4782	5334-5336	IN	denotes	of
T4783	5337-5340	DT	denotes	the
T4785	5341-5345	NN	denotes	VP16
T4787	5345-5346	HYPH	denotes	-
T4786	5346-5351	NN	denotes	PPARδ
T4784	5352-5361	NN	denotes	transgene
T4788	5362-5364	IN	denotes	in
T4789	5365-5372	JJ	denotes	various
T4790	5373-5380	NNS	denotes	tissues
T4791	5380-5381	.	denotes	.
T4792	5381-5456	sentence	denotes	10 μg of total RNA from each tissue was hybridized with a VP16 cDNA probe.
T4793	5382-5384	CD	denotes	10
T4794	5385-5387	NNS	denotes	μg
T4796	5388-5390	IN	denotes	of
T4797	5391-5396	JJ	denotes	total
T4798	5397-5400	NN	denotes	RNA
T4799	5401-5405	IN	denotes	from
T4800	5406-5410	DT	denotes	each
T4801	5411-5417	NN	denotes	tissue
T4802	5418-5421	VBD	denotes	was
T4795	5422-5432	VBN	denotes	hybridized
T4803	5433-5437	IN	denotes	with
T4804	5438-5439	DT	denotes	a
T4806	5440-5444	NN	denotes	VP16
T4807	5445-5449	NN	denotes	cDNA
T4805	5450-5455	NN	denotes	probe
T4808	5455-5456	.	denotes	.
T4809	5456-5492	sentence	denotes	Gastrocnemius muscle was used here.
T4810	5457-5470	NN	denotes	Gastrocnemius
T4811	5471-5477	NN	denotes	muscle
T4813	5478-5481	VBD	denotes	was
T4812	5482-5486	VBN	denotes	used
T4814	5487-5491	RB	denotes	here
T4815	5491-5492	.	denotes	.
T4816	5492-5663	sentence	denotes	(D) Nuclear proteins (15 μg/lane) isolated from gastrocnemius muscle of the transgenic mice (TG) and the wild-type littermates (WT) were probed with indicated antibodies.
T4817	5493-5494	-LRB-	denotes	(
T4818	5494-5495	LS	denotes	D
T4820	5495-5496	-RRB-	denotes	)
T4821	5497-5504	JJ	denotes	Nuclear
T4822	5505-5513	NN	denotes	proteins
T4823	5514-5515	-LRB-	denotes	(
T4825	5515-5517	CD	denotes	15
T4824	5518-5520	NNS	denotes	μg
T4826	5520-5521	SYM	denotes	/
T4827	5521-5525	NN	denotes	lane
T4828	5525-5526	-RRB-	denotes	)
T4829	5527-5535	VBN	denotes	isolated
T4830	5536-5540	IN	denotes	from
T4831	5541-5554	NN	denotes	gastrocnemius
T4832	5555-5561	NN	denotes	muscle
T4833	5562-5564	IN	denotes	of
T4834	5565-5568	DT	denotes	the
T4836	5569-5579	JJ	denotes	transgenic
T4835	5580-5584	NNS	denotes	mice
T4837	5585-5586	-LRB-	denotes	(
T4838	5586-5588	JJ	denotes	TG
T4839	5588-5589	-RRB-	denotes	)
T4840	5590-5593	CC	denotes	and
T4841	5594-5597	DT	denotes	the
T4843	5598-5602	JJ	denotes	wild
T4845	5602-5603	HYPH	denotes	-
T4844	5603-5607	NN	denotes	type
T4842	5608-5619	NNS	denotes	littermates
T4846	5620-5621	-LRB-	denotes	(
T4847	5621-5623	NN	denotes	WT
T4848	5623-5624	-RRB-	denotes	)
T4849	5625-5629	VBD	denotes	were
T4819	5630-5636	VBN	denotes	probed
T4850	5637-5641	IN	denotes	with
T4851	5642-5651	JJ	denotes	indicated
T4852	5652-5662	NNS	denotes	antibodies
T4853	5662-5663	.	denotes	.
T4854	5663-5765	sentence	denotes	The upper, nonspecific band that cross-reacted with the anti-PPARδ antibody serves a loading control.
T4855	5664-5667	DT	denotes	The
T4857	5668-5673	JJ	denotes	upper
T4858	5673-5675	,	denotes	,
T4859	5675-5686	JJ	denotes	nonspecific
T4856	5687-5691	NN	denotes	band
T4861	5692-5696	WDT	denotes	that
T4862	5697-5710	VBD	denotes	cross-reacted
T4863	5711-5715	IN	denotes	with
T4864	5716-5719	DT	denotes	the
T4866	5720-5730	JJ	denotes	anti-PPARδ
T4865	5731-5739	NN	denotes	antibody
T4860	5740-5746	VBZ	denotes	serves
T4867	5747-5748	DT	denotes	a
T4869	5749-5756	NN	denotes	loading
T4868	5757-5764	NN	denotes	control
T4870	5764-5765	.	denotes	.
T1411	5766-5768	TO	denotes	To
T1413	5769-5777	RB	denotes	directly
T1412	5778-5784	VB	denotes	assess
T1415	5785-5788	DT	denotes	the
T1416	5789-5793	NN	denotes	role
T1417	5794-5796	IN	denotes	of
T1418	5797-5807	NN	denotes	activation
T1419	5808-5810	IN	denotes	of
T1420	5811-5816	NN	denotes	PPARδ
T1421	5817-5819	IN	denotes	in
T1422	5820-5827	NN	denotes	control
T1423	5828-5830	IN	denotes	of
T1424	5831-5837	NN	denotes	muscle
T1425	5838-5843	NN	denotes	fiber
T1426	5844-5854	NN	denotes	plasticity
T1427	5855-5858	CC	denotes	and
T1428	5859-5872	JJ	denotes	mitochondrial
T1429	5873-5883	NN	denotes	biogenesis
T1430	5883-5885	,	denotes	,
T1431	5885-5887	PRP	denotes	we
T1414	5888-5897	VBD	denotes	generated
T1432	5898-5902	NNS	denotes	mice
T1433	5903-5913	VBG	denotes	expressing
T1434	5914-5915	DT	denotes	a
T1435	5916-5925	NN	denotes	transgene
T1436	5926-5928	IN	denotes	in
T1438	5929-5934	WDT	denotes	which
T1439	5935-5938	DT	denotes	the
T1441	5939-5941	CD	denotes	78
T1443	5941-5942	HYPH	denotes	-
T1444	5942-5947	NN	denotes	amino
T1445	5947-5948	HYPH	denotes	-
T1442	5948-5952	NN	denotes	acid
T1446	5953-5957	NN	denotes	VP16
T1447	5958-5968	NN	denotes	activation
T1440	5969-5975	NN	denotes	domain
T1448	5976-5979	VBD	denotes	was
T1437	5980-5985	VBN	denotes	fused
T1449	5986-5988	IN	denotes	to
T1450	5989-5992	DT	denotes	the
T1452	5993-5994	NN	denotes	N
T1453	5994-5995	HYPH	denotes	-
T1451	5995-6003	NN	denotes	terminus
T1454	6004-6006	IN	denotes	of
T1455	6007-6011	JJ	denotes	full
T1457	6011-6012	HYPH	denotes	-
T1456	6012-6018	NN	denotes	length
T1458	6019-6024	NN	denotes	PPARδ
T1459	6024-6026	,	denotes	,
T1460	6026-6031	IN	denotes	under
T1461	6032-6039	NN	denotes	control
T1462	6040-6042	IN	denotes	of
T1463	6043-6046	DT	denotes	the
T1465	6047-6050	CD	denotes	2.2
T1467	6050-6051	HYPH	denotes	-
T1466	6051-6053	NN	denotes	kb
T1468	6054-6059	JJ	denotes	human
T1469	6060-6061	NN	denotes	α
T1471	6061-6062	HYPH	denotes	-
T1470	6062-6070	JJ	denotes	skeletal
T1472	6071-6076	NN	denotes	actin
T1464	6077-6085	NN	denotes	promoter
T1473	6085-6086	.	denotes	.
T1474	6086-6316	sentence	denotes	In agreement with the previous characterization of this promoter (Brennan and Hardeman 1993; Clapham et al. 2000), the VP16-PPARδ transgene was selectively expressed in skeletal muscle, with 10-fold less in the heart (Figure 1C).
T1475	6087-6089	IN	denotes	In
T1477	6090-6099	NN	denotes	agreement
T1478	6100-6104	IN	denotes	with
T1479	6105-6108	DT	denotes	the
T1481	6109-6117	JJ	denotes	previous
T1480	6118-6134	NN	denotes	characterization
T1482	6135-6137	IN	denotes	of
T1483	6138-6142	DT	denotes	this
T1484	6143-6151	NN	denotes	promoter
T1485	6152-6153	-LRB-	denotes	(
T1486	6153-6160	NNP	denotes	Brennan
T1487	6161-6164	CC	denotes	and
T1488	6165-6173	NNP	denotes	Hardeman
T1489	6174-6178	CD	denotes	1993
T1490	6178-6179	:	denotes	;
T1491	6180-6187	NNP	denotes	Clapham
T1492	6188-6190	FW	denotes	et
T1493	6191-6194	FW	denotes	al.
T1494	6195-6199	CD	denotes	2000
T1495	6199-6200	-RRB-	denotes	)
T1496	6200-6202	,	denotes	,
T1497	6202-6205	DT	denotes	the
T1499	6206-6210	NN	denotes	VP16
T1501	6210-6211	HYPH	denotes	-
T1500	6211-6216	NN	denotes	PPARδ
T1498	6217-6226	NN	denotes	transgene
T1502	6227-6230	VBD	denotes	was
T1503	6231-6242	RB	denotes	selectively
T1476	6243-6252	VBN	denotes	expressed
T1504	6253-6255	IN	denotes	in
T1505	6256-6264	JJ	denotes	skeletal
T1506	6265-6271	NN	denotes	muscle
T1507	6271-6273	,	denotes	,
T1508	6273-6277	IN	denotes	with
T1510	6278-6280	CD	denotes	10
T1511	6280-6281	HYPH	denotes	-
T1512	6281-6285	RB	denotes	fold
T1509	6286-6290	JJR	denotes	less
T1513	6291-6293	IN	denotes	in
T1514	6294-6297	DT	denotes	the
T1515	6298-6303	NN	denotes	heart
T1516	6304-6305	-LRB-	denotes	(
T1517	6305-6311	NN	denotes	Figure
T1518	6312-6314	CD	denotes	1C
T1519	6314-6315	-RRB-	denotes	)
T1520	6315-6316	.	denotes	.
T1521	6316-6435	sentence	denotes	Among different types of muscle fibers, the levels of VP16-PPARδ expression appeared to be similar (unpublished data).
T1522	6317-6322	IN	denotes	Among
T1524	6323-6332	JJ	denotes	different
T1525	6333-6338	NNS	denotes	types
T1526	6339-6341	IN	denotes	of
T1527	6342-6348	NN	denotes	muscle
T1528	6349-6355	NNS	denotes	fibers
T1529	6355-6357	,	denotes	,
T1530	6357-6360	DT	denotes	the
T1531	6361-6367	NNS	denotes	levels
T1532	6368-6370	IN	denotes	of
T1533	6371-6375	NN	denotes	VP16
T1535	6375-6376	HYPH	denotes	-
T1534	6376-6381	NN	denotes	PPARδ
T1536	6382-6392	NN	denotes	expression
T1523	6393-6401	VBD	denotes	appeared
T1537	6402-6404	TO	denotes	to
T1538	6405-6407	VB	denotes	be
T1539	6408-6415	JJ	denotes	similar
T1540	6416-6417	-LRB-	denotes	(
T1542	6417-6428	JJ	denotes	unpublished
T1541	6429-6433	NNS	denotes	data
T1543	6433-6434	-RRB-	denotes	)
T1544	6434-6435	.	denotes	.
T1545	6435-6595	sentence	denotes	As shown in Figure 1D for gastrocnemius muscle, VP16-PPARδ fusion protein was produced at a level similar to that of endogenous PPARδ in wild-type littermates.
T1546	6436-6438	IN	denotes	As
T1547	6439-6444	VBN	denotes	shown
T1549	6445-6447	IN	denotes	in
T1550	6448-6454	NN	denotes	Figure
T1551	6455-6457	CD	denotes	1D
T1552	6458-6461	IN	denotes	for
T1553	6462-6475	NN	denotes	gastrocnemius
T1554	6476-6482	NN	denotes	muscle
T1555	6482-6484	,	denotes	,
T1556	6484-6488	NN	denotes	VP16
T1558	6488-6489	HYPH	denotes	-
T1557	6489-6494	NN	denotes	PPARδ
T1560	6495-6501	NN	denotes	fusion
T1559	6502-6509	NN	denotes	protein
T1561	6510-6513	VBD	denotes	was
T1548	6514-6522	VBN	denotes	produced
T1562	6523-6525	IN	denotes	at
T1563	6526-6527	DT	denotes	a
T1564	6528-6533	NN	denotes	level
T1565	6534-6541	JJ	denotes	similar
T1566	6542-6544	IN	denotes	to
T1567	6545-6549	DT	denotes	that
T1568	6550-6552	IN	denotes	of
T1569	6553-6563	JJ	denotes	endogenous
T1570	6564-6569	NN	denotes	PPARδ
T1571	6570-6572	IN	denotes	in
T1572	6573-6577	JJ	denotes	wild
T1574	6577-6578	HYPH	denotes	-
T1573	6578-6582	NN	denotes	type
T1575	6583-6594	NNS	denotes	littermates
T1576	6594-6595	.	denotes	.
T1577	6595-6727	sentence	denotes	Interestingly, the level of endogenous muscle PPARδ protein in the transgenic mice was much higher than in the control littermates.
T1578	6596-6609	RB	denotes	Interestingly
T1580	6609-6611	,	denotes	,
T1581	6611-6614	DT	denotes	the
T1582	6615-6620	NN	denotes	level
T1583	6621-6623	IN	denotes	of
T1584	6624-6634	JJ	denotes	endogenous
T1586	6635-6641	NN	denotes	muscle
T1587	6642-6647	NN	denotes	PPARδ
T1585	6648-6655	NN	denotes	protein
T1588	6656-6658	IN	denotes	in
T1589	6659-6662	DT	denotes	the
T1591	6663-6673	JJ	denotes	transgenic
T1590	6674-6678	NNS	denotes	mice
T1579	6679-6682	VBD	denotes	was
T1592	6683-6687	RB	denotes	much
T1593	6688-6694	JJR	denotes	higher
T1594	6695-6699	IN	denotes	than
T1595	6700-6702	IN	denotes	in
T1596	6703-6706	DT	denotes	the
T1598	6707-6714	NN	denotes	control
T1597	6715-6726	NNS	denotes	littermates
T1599	6726-6727	.	denotes	.
T1600	6727-6907	sentence	denotes	The substantial increase of endogenous PPARδ may have been caused by a switch to type I fiber (see below), which intrinsically expresses higher levels of PPARδ (Figure 1A and 1B).
T1601	6728-6731	DT	denotes	The
T1603	6732-6743	JJ	denotes	substantial
T1602	6744-6752	NN	denotes	increase
T1605	6753-6755	IN	denotes	of
T1606	6756-6766	JJ	denotes	endogenous
T1607	6767-6772	NN	denotes	PPARδ
T1608	6773-6776	MD	denotes	may
T1609	6777-6781	VB	denotes	have
T1610	6782-6786	VBN	denotes	been
T1604	6787-6793	VBN	denotes	caused
T1611	6794-6796	IN	denotes	by
T1612	6797-6798	DT	denotes	a
T1613	6799-6805	NN	denotes	switch
T1614	6806-6808	IN	denotes	to
T1615	6809-6813	NN	denotes	type
T1617	6814-6815	CD	denotes	I
T1616	6816-6821	NN	denotes	fiber
T1618	6822-6823	-LRB-	denotes	(
T1619	6823-6826	VB	denotes	see
T1620	6827-6832	RB	denotes	below
T1621	6832-6833	-RRB-	denotes	)
T1622	6833-6835	,	denotes	,
T1623	6835-6840	WDT	denotes	which
T1625	6841-6854	RB	denotes	intrinsically
T1624	6855-6864	VBZ	denotes	expresses
T1626	6865-6871	JJR	denotes	higher
T1627	6872-6878	NNS	denotes	levels
T1628	6879-6881	IN	denotes	of
T1629	6882-6887	NN	denotes	PPARδ
T1630	6888-6889	-LRB-	denotes	(
T1632	6889-6895	NN	denotes	Figure
T1631	6896-6898	CD	denotes	1A
T1633	6899-6902	CC	denotes	and
T1634	6903-6905	CD	denotes	1B
T1635	6905-6906	-RRB-	denotes	)
T1636	6906-6907	.	denotes	.
T1637	6907-7103	sentence	denotes	Type I muscle can be readily distinguished from type II or mixed muscle by its red color, because of its high concentration of myoglobin, a protein typically expressed in oxidative muscle fibers.
T1638	6908-6912	NN	denotes	Type
T1640	6913-6914	CD	denotes	I
T1639	6915-6921	NN	denotes	muscle
T1642	6922-6925	MD	denotes	can
T1643	6926-6928	VB	denotes	be
T1644	6929-6936	RB	denotes	readily
T1641	6937-6950	VBN	denotes	distinguished
T1645	6951-6955	IN	denotes	from
T1646	6956-6960	NN	denotes	type
T1648	6961-6963	CD	denotes	II
T1649	6964-6966	CC	denotes	or
T1650	6967-6972	VBN	denotes	mixed
T1647	6973-6979	NN	denotes	muscle
T1651	6980-6982	IN	denotes	by
T1652	6983-6986	PRP$	denotes	its
T1654	6987-6990	JJ	denotes	red
T1653	6991-6996	NN	denotes	color
T1655	6996-6998	,	denotes	,
T1656	6998-7005	IN	denotes	because
T1657	7006-7008	IN	denotes	of
T1658	7009-7012	PRP$	denotes	its
T1660	7013-7017	JJ	denotes	high
T1659	7018-7031	NN	denotes	concentration
T1661	7032-7034	IN	denotes	of
T1662	7035-7044	NN	denotes	myoglobin
T1663	7044-7046	,	denotes	,
T1664	7046-7047	DT	denotes	a
T1665	7048-7055	NN	denotes	protein
T1666	7056-7065	RB	denotes	typically
T1667	7066-7075	VBN	denotes	expressed
T1668	7076-7078	IN	denotes	in
T1669	7079-7088	JJ	denotes	oxidative
T1671	7089-7095	NN	denotes	muscle
T1670	7096-7102	NNS	denotes	fibers
T1672	7102-7103	.	denotes	.
T1673	7103-7266	sentence	denotes	We found that muscles in the transgenic mice appeared redder (Figure 2A), which is particularly evident in the mixed type I/II fibers of the hindlimb (Figure 2B).
T1674	7104-7106	PRP	denotes	We
T1675	7107-7112	VBD	denotes	found
T1676	7113-7117	IN	denotes	that
T1678	7118-7125	NNS	denotes	muscles
T1679	7126-7128	IN	denotes	in
T1680	7129-7132	DT	denotes	the
T1682	7133-7143	JJ	denotes	transgenic
T1681	7144-7148	NNS	denotes	mice
T1677	7149-7157	VBD	denotes	appeared
T1683	7158-7164	JJR	denotes	redder
T1684	7165-7166	-LRB-	denotes	(
T1685	7166-7172	NN	denotes	Figure
T1686	7173-7175	CD	denotes	2A
T1687	7175-7176	-RRB-	denotes	)
T1688	7176-7178	,	denotes	,
T1689	7178-7183	WDT	denotes	which
T1690	7184-7186	VBZ	denotes	is
T1691	7187-7199	RB	denotes	particularly
T1692	7200-7207	JJ	denotes	evident
T1693	7208-7210	IN	denotes	in
T1694	7211-7214	DT	denotes	the
T1696	7215-7220	JJ	denotes	mixed
T1698	7221-7225	NN	denotes	type
T1699	7226-7227	CD	denotes	I
T1700	7227-7228	HYPH	denotes	/
T1697	7228-7230	CD	denotes	II
T1695	7231-7237	NNS	denotes	fibers
T1701	7238-7240	IN	denotes	of
T1702	7241-7244	DT	denotes	the
T1703	7245-7253	NN	denotes	hindlimb
T1704	7254-7255	-LRB-	denotes	(
T1705	7255-7261	NN	denotes	Figure
T1706	7262-7264	CD	denotes	2B
T1707	7264-7265	-RRB-	denotes	)
T1708	7265-7266	.	denotes	.
T1709	7266-7361	sentence	denotes	Indeed, metachromatic staining revealed a substantial muscle fiber transformation (Figure 2C).
T1710	7267-7273	RB	denotes	Indeed
T1712	7273-7275	,	denotes	,
T1713	7275-7288	JJ	denotes	metachromatic
T1714	7289-7297	NN	denotes	staining
T1711	7298-7306	VBD	denotes	revealed
T1715	7307-7308	DT	denotes	a
T1717	7309-7320	JJ	denotes	substantial
T1718	7321-7327	NN	denotes	muscle
T1719	7328-7333	NN	denotes	fiber
T1716	7334-7348	NN	denotes	transformation
T1720	7349-7350	-LRB-	denotes	(
T1721	7350-7356	NN	denotes	Figure
T1722	7357-7359	CD	denotes	2C
T1723	7359-7360	-RRB-	denotes	)
T1724	7360-7361	.	denotes	.
T1725	7361-7450	sentence	denotes	In gastrocnemius muscle, we estimated that there was a 2-fold increase of type I fibers.
T1726	7362-7364	IN	denotes	In
T1728	7365-7378	NN	denotes	gastrocnemius
T1729	7379-7385	NN	denotes	muscle
T1730	7385-7387	,	denotes	,
T1731	7387-7389	PRP	denotes	we
T1727	7390-7399	VBD	denotes	estimated
T1732	7400-7404	IN	denotes	that
T1734	7405-7410	EX	denotes	there
T1733	7411-7414	VBD	denotes	was
T1735	7415-7416	DT	denotes	a
T1737	7417-7423	JJ	denotes	2-fold
T1736	7424-7432	NN	denotes	increase
T1738	7433-7435	IN	denotes	of
T1739	7436-7440	NN	denotes	type
T1741	7441-7442	CD	denotes	I
T1740	7443-7449	NNS	denotes	fibers
T1742	7449-7450	.	denotes	.
T1743	7450-7604	sentence	denotes	A diagnostic component of oxidative fibers is their high myoglobin and mitochondrial content, which is supported by the mRNA analysis shown in Figure 3A.
T1744	7451-7452	DT	denotes	A
T1746	7453-7463	JJ	denotes	diagnostic
T1745	7464-7473	NN	denotes	component
T1748	7474-7476	IN	denotes	of
T1749	7477-7486	JJ	denotes	oxidative
T1750	7487-7493	NNS	denotes	fibers
T1747	7494-7496	VBZ	denotes	is
T1751	7497-7502	PRP$	denotes	their
T1753	7503-7507	JJ	denotes	high
T1754	7508-7517	NN	denotes	myoglobin
T1755	7518-7521	CC	denotes	and
T1756	7522-7535	JJ	denotes	mitochondrial
T1752	7536-7543	NN	denotes	content
T1757	7543-7545	,	denotes	,
T1758	7545-7550	WDT	denotes	which
T1760	7551-7553	VBZ	denotes	is
T1759	7554-7563	VBN	denotes	supported
T1761	7564-7566	IN	denotes	by
T1762	7567-7570	DT	denotes	the
T1764	7571-7575	NN	denotes	mRNA
T1763	7576-7584	NN	denotes	analysis
T1765	7585-7590	VBN	denotes	shown
T1766	7591-7593	IN	denotes	in
T1767	7594-7600	NN	denotes	Figure
T1768	7601-7603	CD	denotes	3A
T1769	7603-7604	.	denotes	.
T1770	7604-7813	sentence	denotes	In addition to myoglobin, mitochondrial components for electron transfer (cytochrome c and cytochrome c oxidase [COX] II and IV) and fatty-acid β-oxidation enzymes were elevated (Figure 3A; unpublished data).
T1771	7605-7607	IN	denotes	In
T1773	7608-7616	NN	denotes	addition
T1774	7617-7619	IN	denotes	to
T1775	7620-7629	NN	denotes	myoglobin
T1776	7629-7631	,	denotes	,
T1777	7631-7644	JJ	denotes	mitochondrial
T1778	7645-7655	NNS	denotes	components
T1779	7656-7659	IN	denotes	for
T1780	7660-7668	NN	denotes	electron
T1781	7669-7677	NN	denotes	transfer
T1782	7678-7679	-LRB-	denotes	(
T1784	7679-7689	NN	denotes	cytochrome
T1783	7690-7691	NN	denotes	c
T1785	7692-7695	CC	denotes	and
T1786	7696-7706	NN	denotes	cytochrome
T1787	7707-7708	NN	denotes	c
T1788	7709-7716	NN	denotes	oxidase
T1789	7717-7718	-LRB-	denotes	[
T1790	7718-7721	NN	denotes	COX
T1791	7721-7722	-RRB-	denotes	]
T1792	7723-7725	CD	denotes	II
T1793	7726-7729	CC	denotes	and
T1794	7730-7732	CD	denotes	IV
T1795	7732-7733	-RRB-	denotes	)
T1796	7734-7737	CC	denotes	and
T1797	7738-7743	JJ	denotes	fatty
T1799	7743-7744	HYPH	denotes	-
T1798	7744-7748	NN	denotes	acid
T1801	7749-7750	NN	denotes	β
T1803	7750-7751	HYPH	denotes	-
T1802	7751-7760	NN	denotes	oxidation
T1800	7761-7768	NNS	denotes	enzymes
T1804	7769-7773	VBD	denotes	were
T1772	7774-7782	VBN	denotes	elevated
T1805	7783-7784	-LRB-	denotes	(
T1807	7784-7790	NN	denotes	Figure
T1808	7791-7793	CD	denotes	3A
T1809	7793-7794	:	denotes	;
T1810	7795-7806	JJ	denotes	unpublished
T1806	7807-7811	NNS	denotes	data
T1811	7811-7812	-RRB-	denotes	)
T1812	7812-7813	.	denotes	.
T1813	7813-8052	sentence	denotes	These effects appear to be direct consequences of PPARδ activation, as levels of PGC-1α, a coactivator involved in muscle fiber switch and mitochondrial biogenesis (Wu et al. 1999; Lehman et al. 2000; Lin et al. 2002), remained unchanged.
T1814	7814-7819	DT	denotes	These
T1815	7820-7827	NNS	denotes	effects
T1816	7828-7834	VBP	denotes	appear
T1817	7835-7837	TO	denotes	to
T1818	7838-7840	VB	denotes	be
T1819	7841-7847	JJ	denotes	direct
T1820	7848-7860	NNS	denotes	consequences
T1821	7861-7863	IN	denotes	of
T1822	7864-7869	NN	denotes	PPARδ
T1823	7870-7880	NN	denotes	activation
T1824	7880-7882	,	denotes	,
T1825	7882-7884	IN	denotes	as
T1827	7885-7891	NNS	denotes	levels
T1828	7892-7894	IN	denotes	of
T1829	7895-7898	NN	denotes	PGC
T1830	7898-7899	HYPH	denotes	-
T1831	7899-7901	CD	denotes	1α
T1832	7901-7903	,	denotes	,
T1833	7903-7904	DT	denotes	a
T1834	7905-7916	NN	denotes	coactivator
T1835	7917-7925	VBN	denotes	involved
T1836	7926-7928	IN	denotes	in
T1837	7929-7935	NN	denotes	muscle
T1838	7936-7941	NN	denotes	fiber
T1839	7942-7948	NN	denotes	switch
T1840	7949-7952	CC	denotes	and
T1841	7953-7966	JJ	denotes	mitochondrial
T1842	7967-7977	NN	denotes	biogenesis
T1843	7978-7979	-LRB-	denotes	(
T1844	7979-7981	NNP	denotes	Wu
T1845	7982-7984	FW	denotes	et
T1846	7985-7988	FW	denotes	al.
T1847	7989-7993	CD	denotes	1999
T1848	7993-7994	:	denotes	;
T1849	7995-8001	NNP	denotes	Lehman
T1850	8002-8004	FW	denotes	et
T1851	8005-8008	FW	denotes	al.
T1852	8009-8013	CD	denotes	2000
T1853	8013-8014	:	denotes	;
T1854	8015-8018	NNP	denotes	Lin
T1855	8019-8021	FW	denotes	et
T1856	8022-8025	FW	denotes	al.
T1857	8026-8030	CD	denotes	2002
T1858	8030-8031	-RRB-	denotes	)
T1859	8031-8033	,	denotes	,
T1826	8033-8041	VBD	denotes	remained
T1860	8042-8051	JJ	denotes	unchanged
T1861	8051-8052	.	denotes	.
T1862	8052-8201	sentence	denotes	Southern blot analysis detected a substantially higher copy number of the mitochondrial genome–encoded COXII DNA in the transgenic mice (Figure 3B).
T1863	8053-8061	NNP	denotes	Southern
T1864	8062-8066	NN	denotes	blot
T1865	8067-8075	NN	denotes	analysis
T1866	8076-8084	VBD	denotes	detected
T1867	8085-8086	DT	denotes	a
T1869	8087-8100	RB	denotes	substantially
T1870	8101-8107	JJR	denotes	higher
T1871	8108-8112	NN	denotes	copy
T1868	8113-8119	NN	denotes	number
T1872	8120-8122	IN	denotes	of
T1873	8123-8126	DT	denotes	the
T1875	8127-8140	JJ	denotes	mitochondrial
T1876	8141-8147	NN	denotes	genome
T1878	8147-8148	HYPH	denotes	–
T1877	8148-8155	VBN	denotes	encoded
T1879	8156-8161	NN	denotes	COXII
T1874	8162-8165	NN	denotes	DNA
T1880	8166-8168	IN	denotes	in
T1881	8169-8172	DT	denotes	the
T1883	8173-8183	JJ	denotes	transgenic
T1882	8184-8188	NNS	denotes	mice
T1884	8189-8190	-LRB-	denotes	(
T1885	8190-8196	NN	denotes	Figure
T1886	8197-8199	CD	denotes	3B
T1887	8199-8200	-RRB-	denotes	)
T1888	8200-8201	.	denotes	.
T1889	8201-8302	sentence	denotes	Mitochondrial DNA was increased 2.3-fold in gastrocnemius muscle of the transgenic mice (Figure 3C).
T1890	8202-8215	JJ	denotes	Mitochondrial
T1891	8216-8219	NN	denotes	DNA
T1893	8220-8223	VBD	denotes	was
T1892	8224-8233	VBN	denotes	increased
T1894	8234-8237	CD	denotes	2.3
T1895	8237-8238	HYPH	denotes	-
T1896	8238-8242	RB	denotes	fold
T1897	8243-8245	IN	denotes	in
T1898	8246-8259	NN	denotes	gastrocnemius
T1899	8260-8266	NN	denotes	muscle
T1900	8267-8269	IN	denotes	of
T1901	8270-8273	DT	denotes	the
T1903	8274-8284	JJ	denotes	transgenic
T1902	8285-8289	NNS	denotes	mice
T1904	8290-8291	-LRB-	denotes	(
T1905	8291-8297	NN	denotes	Figure
T1906	8298-8300	CD	denotes	3C
T1907	8300-8301	-RRB-	denotes	)
T1908	8301-8302	.	denotes	.
T1909	8302-8438	sentence	denotes	These results reveal a marked stimulation of mitochondrial biogenesis and further support the idea that there is a muscle fiber switch.
T1910	8303-8308	DT	denotes	These
T1911	8309-8316	NNS	denotes	results
T1912	8317-8323	VBP	denotes	reveal
T1913	8324-8325	DT	denotes	a
T1915	8326-8332	JJ	denotes	marked
T1914	8333-8344	NN	denotes	stimulation
T1916	8345-8347	IN	denotes	of
T1917	8348-8361	JJ	denotes	mitochondrial
T1918	8362-8372	NN	denotes	biogenesis
T1919	8373-8376	CC	denotes	and
T1920	8377-8384	RB	denotes	further
T1921	8385-8392	VBP	denotes	support
T1922	8393-8396	DT	denotes	the
T1923	8397-8401	NN	denotes	idea
T1924	8402-8406	IN	denotes	that
T1926	8407-8412	EX	denotes	there
T1925	8413-8415	VBZ	denotes	is
T1927	8416-8417	DT	denotes	a
T1929	8418-8424	NN	denotes	muscle
T1930	8425-8430	NN	denotes	fiber
T1928	8431-8437	NN	denotes	switch
T1931	8437-8438	.	denotes	.
T1932	8438-8499	sentence	denotes	This conclusion was also confirmed by Western blot analysis.
T1933	8439-8443	DT	denotes	This
T1934	8444-8454	NN	denotes	conclusion
T1936	8455-8458	VBD	denotes	was
T1937	8459-8463	RB	denotes	also
T1935	8464-8473	VBN	denotes	confirmed
T1938	8474-8476	IN	denotes	by
T1939	8477-8484	NNP	denotes	Western
T1940	8485-8489	NN	denotes	blot
T1941	8490-8498	NN	denotes	analysis
T1942	8498-8499	.	denotes	.
T1943	8499-8636	sentence	denotes	As shown in Figure 3D, the characteristic type I fiber proteins, such as myoglobin and cytochrome c and b, were significantly increased.
T1944	8500-8502	IN	denotes	As
T1945	8503-8508	VBN	denotes	shown
T1947	8509-8511	IN	denotes	in
T1948	8512-8518	NN	denotes	Figure
T1949	8519-8521	CD	denotes	3D
T1950	8521-8523	,	denotes	,
T1951	8523-8526	DT	denotes	the
T1953	8527-8541	JJ	denotes	characteristic
T1954	8542-8546	NN	denotes	type
T1956	8547-8548	CD	denotes	I
T1955	8549-8554	NN	denotes	fiber
T1952	8555-8563	NN	denotes	proteins
T1957	8563-8565	,	denotes	,
T1958	8565-8569	JJ	denotes	such
T1959	8570-8572	IN	denotes	as
T1960	8573-8582	NN	denotes	myoglobin
T1961	8583-8586	CC	denotes	and
T1962	8587-8597	NN	denotes	cytochrome
T1964	8598-8599	NN	denotes	c
T1965	8600-8603	CC	denotes	and
T1963	8604-8605	NN	denotes	b
T1966	8605-8607	,	denotes	,
T1967	8607-8611	VBD	denotes	were
T1968	8612-8625	RB	denotes	significantly
T1946	8626-8635	VBN	denotes	increased
T1969	8635-8636	.	denotes	.
T1970	8636-8914	sentence	denotes	More importantly, the specialized contraction protein troponin I (slow) of type I fiber was robustly induced; this was accompanied by a marked reduction of the specialized contraction protein troponin I (fast) of type II fiber, indicating a high degree of fiber transformation.
T1971	8637-8641	RBR	denotes	More
T1972	8642-8653	RB	denotes	importantly
T1974	8653-8655	,	denotes	,
T1975	8655-8658	DT	denotes	the
T1977	8659-8670	VBN	denotes	specialized
T1978	8671-8682	NN	denotes	contraction
T1976	8683-8690	NN	denotes	protein
T1979	8691-8699	NN	denotes	troponin
T1980	8700-8701	CD	denotes	I
T1981	8702-8703	-LRB-	denotes	(
T1982	8703-8707	JJ	denotes	slow
T1983	8707-8708	-RRB-	denotes	)
T1984	8709-8711	IN	denotes	of
T1985	8712-8716	NN	denotes	type
T1987	8717-8718	CD	denotes	I
T1986	8719-8724	NN	denotes	fiber
T1988	8725-8728	VBD	denotes	was
T1989	8729-8737	RB	denotes	robustly
T1973	8738-8745	VBN	denotes	induced
T1991	8745-8746	:	denotes	;
T1992	8747-8751	DT	denotes	this
T1993	8752-8755	VBD	denotes	was
T1990	8756-8767	VBN	denotes	accompanied
T1994	8768-8770	IN	denotes	by
T1995	8771-8772	DT	denotes	a
T1997	8773-8779	JJ	denotes	marked
T1996	8780-8789	NN	denotes	reduction
T1998	8790-8792	IN	denotes	of
T1999	8793-8796	DT	denotes	the
T2001	8797-8808	VBN	denotes	specialized
T2002	8809-8820	NN	denotes	contraction
T2000	8821-8828	NN	denotes	protein
T2003	8829-8837	NN	denotes	troponin
T2004	8838-8839	CD	denotes	I
T2005	8840-8841	-LRB-	denotes	(
T2006	8841-8845	JJ	denotes	fast
T2007	8845-8846	-RRB-	denotes	)
T2008	8847-8849	IN	denotes	of
T2009	8850-8854	NN	denotes	type
T2011	8855-8857	CD	denotes	II
T2010	8858-8863	NN	denotes	fiber
T2012	8863-8865	,	denotes	,
T2013	8865-8875	VBG	denotes	indicating
T2014	8876-8877	DT	denotes	a
T2016	8878-8882	JJ	denotes	high
T2015	8883-8889	NN	denotes	degree
T2017	8890-8892	IN	denotes	of
T2018	8893-8898	NN	denotes	fiber
T2019	8899-8913	NN	denotes	transformation
T2020	8913-8914	.	denotes	.
T2021	8914-9011	sentence	denotes	We next examined whether acute activation of endogenous PPARδ would induce similar target genes.
T2022	8915-8917	PRP	denotes	We
T2024	8918-8922	RB	denotes	next
T2023	8923-8931	VBD	denotes	examined
T2025	8932-8939	IN	denotes	whether
T2027	8940-8945	JJ	denotes	acute
T2028	8946-8956	NN	denotes	activation
T2029	8957-8959	IN	denotes	of
T2030	8960-8970	JJ	denotes	endogenous
T2031	8971-8976	NN	denotes	PPARδ
T2032	8977-8982	MD	denotes	would
T2026	8983-8989	VB	denotes	induce
T2033	8990-8997	JJ	denotes	similar
T2035	8998-9004	NN	denotes	target
T2034	9005-9010	NNS	denotes	genes
T2036	9010-9011	.	denotes	.
T2037	9011-9304	sentence	denotes	In agreement with the chronic effects in the transgenic mice, we found that, after treatment of wild-type C57B6J mice with the PPARδ-specific agonist GW501516 for only 10 d, genes for slow fiber contractile proteins, mitochondrial biogenesis, and β-oxidation were all upregulated (Figure 3E).
T2038	9012-9014	IN	denotes	In
T2040	9015-9024	NN	denotes	agreement
T2041	9025-9029	IN	denotes	with
T2042	9030-9033	DT	denotes	the
T2044	9034-9041	JJ	denotes	chronic
T2043	9042-9049	NNS	denotes	effects
T2045	9050-9052	IN	denotes	in
T2046	9053-9056	DT	denotes	the
T2048	9057-9067	JJ	denotes	transgenic
T2047	9068-9072	NNS	denotes	mice
T2049	9072-9074	,	denotes	,
T2050	9074-9076	PRP	denotes	we
T2039	9077-9082	VBD	denotes	found
T2051	9083-9087	IN	denotes	that
T2053	9087-9089	,	denotes	,
T2054	9089-9094	IN	denotes	after
T2055	9095-9104	NN	denotes	treatment
T2056	9105-9107	IN	denotes	of
T2057	9108-9112	JJ	denotes	wild
T2059	9112-9113	HYPH	denotes	-
T2058	9113-9117	NN	denotes	type
T2061	9118-9124	NN	denotes	C57B6J
T2060	9125-9129	NNS	denotes	mice
T2062	9130-9134	IN	denotes	with
T2063	9135-9138	DT	denotes	the
T2065	9139-9144	NN	denotes	PPARδ
T2067	9144-9145	HYPH	denotes	-
T2066	9145-9153	JJ	denotes	specific
T2068	9154-9161	NN	denotes	agonist
T2064	9162-9170	NN	denotes	GW501516
T2069	9171-9174	IN	denotes	for
T2070	9175-9179	RB	denotes	only
T2072	9180-9182	CD	denotes	10
T2071	9183-9184	NNS	denotes	d
T2073	9184-9186	,	denotes	,
T2074	9186-9191	NNS	denotes	genes
T2075	9192-9195	IN	denotes	for
T2076	9196-9200	JJ	denotes	slow
T2077	9201-9206	NN	denotes	fiber
T2079	9207-9218	JJ	denotes	contractile
T2078	9219-9227	NN	denotes	proteins
T2080	9227-9229	,	denotes	,
T2081	9229-9242	JJ	denotes	mitochondrial
T2082	9243-9253	NN	denotes	biogenesis
T2083	9253-9255	,	denotes	,
T2084	9255-9258	CC	denotes	and
T2085	9259-9260	NN	denotes	β
T2087	9260-9261	HYPH	denotes	-
T2086	9261-9270	NN	denotes	oxidation
T2088	9271-9275	VBD	denotes	were
T2089	9276-9279	RB	denotes	all
T2052	9280-9291	VBN	denotes	upregulated
T2090	9292-9293	-LRB-	denotes	(
T2091	9293-9299	NN	denotes	Figure
T2092	9300-9302	CD	denotes	3E
T2093	9302-9303	-RRB-	denotes	)
T2094	9303-9304	.	denotes	.
T2095	9304-9471	sentence	denotes	This indicates that rapid, systematic, and coordinated changes of muscle fiber properties toward type I can be achieved by activation of the endogenous PPARδ pathway.
T2096	9305-9309	DT	denotes	This
T2097	9310-9319	VBZ	denotes	indicates
T2098	9320-9324	IN	denotes	that
T2100	9325-9330	JJ	denotes	rapid
T2102	9330-9332	,	denotes	,
T2103	9332-9342	JJ	denotes	systematic
T2104	9342-9344	,	denotes	,
T2105	9344-9347	CC	denotes	and
T2106	9348-9359	VBN	denotes	coordinated
T2101	9360-9367	NNS	denotes	changes
T2107	9368-9370	IN	denotes	of
T2108	9371-9377	NN	denotes	muscle
T2110	9378-9383	NN	denotes	fiber
T2109	9384-9394	NNS	denotes	properties
T2111	9395-9401	IN	denotes	toward
T2112	9402-9406	NN	denotes	type
T2113	9407-9408	CD	denotes	I
T2114	9409-9412	MD	denotes	can
T2115	9413-9415	VB	denotes	be
T2099	9416-9424	VBN	denotes	achieved
T2116	9425-9427	IN	denotes	by
T2117	9428-9438	NN	denotes	activation
T2118	9439-9441	IN	denotes	of
T2119	9442-9445	DT	denotes	the
T2121	9446-9456	JJ	denotes	endogenous
T2122	9457-9462	NN	denotes	PPARδ
T2120	9463-9470	NN	denotes	pathway
T2123	9470-9471	.	denotes	.
T4894	9482-9491	VBN	denotes	Increased
T4896	9492-9501	JJ	denotes	Oxidative
T4897	9502-9506	NN	denotes	Type
T4898	9507-9508	CD	denotes	I
T4895	9509-9515	NNS	denotes	Fibers
T4899	9516-9518	IN	denotes	in
T4900	9519-9522	DT	denotes	the
T4902	9523-9533	JJ	denotes	Transgenic
T4901	9534-9538	NNS	denotes	Mice
T4903	9538-9626	sentence	denotes	(A and B) Muscles in transgenic mice (TG) are redder than those in wild-type mice (WT).
T4904	9539-9540	-LRB-	denotes	(
T4905	9540-9541	LS	denotes	A
T4907	9542-9545	CC	denotes	and
T4908	9546-9547	LS	denotes	B
T4909	9547-9548	-RRB-	denotes	)
T4910	9549-9556	NNS	denotes	Muscles
T4911	9557-9559	IN	denotes	in
T4912	9560-9570	JJ	denotes	transgenic
T4913	9571-9575	NNS	denotes	mice
T4914	9576-9577	-LRB-	denotes	(
T4915	9577-9579	JJ	denotes	TG
T4916	9579-9580	-RRB-	denotes	)
T4906	9581-9584	VBP	denotes	are
T4917	9585-9591	JJR	denotes	redder
T4918	9592-9596	IN	denotes	than
T4919	9597-9602	DT	denotes	those
T4920	9603-9605	IN	denotes	in
T4921	9606-9610	JJ	denotes	wild
T4923	9610-9611	HYPH	denotes	-
T4922	9611-9615	NN	denotes	type
T4924	9616-9620	NNS	denotes	mice
T4925	9621-9622	-LRB-	denotes	(
T4926	9622-9624	NN	denotes	WT
T4927	9624-9625	-RRB-	denotes	)
T4928	9625-9626	.	denotes	.
T4929	9626-9686	sentence	denotes	(C) Metachromatic staining of the type II plantaris muscle.
T4930	9627-9628	-LRB-	denotes	(
T4931	9628-9629	LS	denotes	C
T4933	9629-9630	-RRB-	denotes	)
T4934	9631-9644	JJ	denotes	Metachromatic
T4932	9645-9653	NN	denotes	staining
T4935	9654-9656	IN	denotes	of
T4936	9657-9660	DT	denotes	the
T4938	9661-9665	NN	denotes	type
T4939	9666-9668	CD	denotes	II
T4940	9669-9678	NN	denotes	plantaris
T4937	9679-9685	NN	denotes	muscle
T4941	9685-9686	.	denotes	.
T4942	9686-9723	sentence	denotes	Type I fibers are stained dark blue.
T4943	9687-9691	NN	denotes	Type
T4945	9692-9693	CD	denotes	I
T4944	9694-9700	NNS	denotes	fibers
T4947	9701-9704	VBP	denotes	are
T4946	9705-9712	VBN	denotes	stained
T4948	9713-9717	RB	denotes	dark
T4949	9718-9722	JJ	denotes	blue
T4950	9722-9723	.	denotes	.
T5034	9734-9744	NN	denotes	Activation
T5036	9745-9747	IN	denotes	of
T5037	9748-9753	NN	denotes	PPARδ
T5035	9754-9761	VBZ	denotes	Induces
T5038	9762-9767	NNS	denotes	Genes
T5039	9768-9775	JJ	denotes	Typical
T5040	9776-9779	IN	denotes	for
T5041	9780-9784	NN	denotes	Type
T5043	9785-9786	CD	denotes	I
T5042	9787-9793	NNS	denotes	Fibers
T5044	9794-9797	CC	denotes	and
T5045	9798-9806	VBZ	denotes	Promotes
T5046	9807-9820	JJ	denotes	Mitochondrial
T5047	9821-9831	NN	denotes	Biogenesis
T5048	9831-9977	sentence	denotes	(A) Total RNA (10 μg/lane) prepared from gastrocnemius muscle of transgenic (TG) and wild-type (WT) littermates was probed with indicated probes.
T5049	9832-9833	-LRB-	denotes	(
T5050	9833-9834	LS	denotes	A
T5052	9834-9835	-RRB-	denotes	)
T5053	9836-9841	JJ	denotes	Total
T5054	9842-9845	NN	denotes	RNA
T5055	9846-9847	-LRB-	denotes	(
T5057	9847-9849	CD	denotes	10
T5056	9850-9852	NNS	denotes	μg
T5058	9852-9853	SYM	denotes	/
T5059	9853-9857	NN	denotes	lane
T5060	9857-9858	-RRB-	denotes	)
T5061	9859-9867	VBN	denotes	prepared
T5062	9868-9872	IN	denotes	from
T5063	9873-9886	NN	denotes	gastrocnemius
T5064	9887-9893	NN	denotes	muscle
T5065	9894-9896	IN	denotes	of
T5066	9897-9907	JJ	denotes	transgenic
T5068	9908-9909	-LRB-	denotes	(
T5069	9909-9911	JJ	denotes	TG
T5070	9911-9912	-RRB-	denotes	)
T5071	9913-9916	CC	denotes	and
T5072	9917-9921	JJ	denotes	wild
T5074	9921-9922	HYPH	denotes	-
T5073	9922-9926	NN	denotes	type
T5075	9927-9928	-LRB-	denotes	(
T5076	9928-9930	NN	denotes	WT
T5077	9930-9931	-RRB-	denotes	)
T5067	9932-9943	NNS	denotes	littermates
T5078	9944-9947	VBD	denotes	was
T5051	9948-9954	VBN	denotes	probed
T5079	9955-9959	IN	denotes	with
T5080	9960-9969	VBN	denotes	indicated
T5081	9970-9976	NNS	denotes	probes
T5082	9976-9977	.	denotes	.
T5083	9977-10031	sentence	denotes	The fold increase of induction of each gene is shown.
T5084	9978-9981	DT	denotes	The
T5086	9982-9986	JJ	denotes	fold
T5085	9987-9995	NN	denotes	increase
T5088	9996-9998	IN	denotes	of
T5089	9999-10008	NN	denotes	induction
T5090	10009-10011	IN	denotes	of
T5091	10012-10016	DT	denotes	each
T5092	10017-10021	NN	denotes	gene
T5093	10022-10024	VBZ	denotes	is
T5087	10025-10030	VBN	denotes	shown
T5094	10030-10031	.	denotes	.
T5095	10031-10248	sentence	denotes	(B) Total genomic DNA (10 μg/lane) prepared from gastrocnemius muscle was digested with Nco1 and subjected to Southern analysis with COXII (mitochondrial genome–encoded) and MCIP1 (nuclear genome–encoded) DNA probes.
T5096	10032-10033	-LRB-	denotes	(
T5097	10033-10034	LS	denotes	B
T5099	10034-10035	-RRB-	denotes	)
T5100	10036-10041	JJ	denotes	Total
T5102	10042-10049	JJ	denotes	genomic
T5101	10050-10053	NN	denotes	DNA
T5103	10054-10055	-LRB-	denotes	(
T5105	10055-10057	CD	denotes	10
T5104	10058-10060	NNS	denotes	μg
T5106	10060-10061	SYM	denotes	/
T5107	10061-10065	NN	denotes	lane
T5108	10065-10066	-RRB-	denotes	)
T5109	10067-10075	VBN	denotes	prepared
T5110	10076-10080	IN	denotes	from
T5111	10081-10094	NN	denotes	gastrocnemius
T5112	10095-10101	NN	denotes	muscle
T5113	10102-10105	VBD	denotes	was
T5098	10106-10114	VBN	denotes	digested
T5114	10115-10119	IN	denotes	with
T5115	10120-10124	NN	denotes	Nco1
T5116	10125-10128	CC	denotes	and
T5117	10129-10138	VBN	denotes	subjected
T5118	10139-10141	IN	denotes	to
T5119	10142-10150	NNP	denotes	Southern
T5120	10151-10159	NN	denotes	analysis
T5121	10160-10164	IN	denotes	with
T5122	10165-10170	NN	denotes	COXII
T5124	10171-10172	-LRB-	denotes	(
T5126	10172-10185	JJ	denotes	mitochondrial
T5127	10186-10192	NN	denotes	genome
T5128	10192-10193	HYPH	denotes	–
T5125	10193-10200	VBN	denotes	encoded
T5129	10200-10201	-RRB-	denotes	)
T5130	10202-10205	CC	denotes	and
T5131	10206-10211	NN	denotes	MCIP1
T5132	10212-10213	-LRB-	denotes	(
T5134	10213-10220	JJ	denotes	nuclear
T5135	10221-10227	NN	denotes	genome
T5136	10227-10228	HYPH	denotes	–
T5133	10228-10235	VBN	denotes	encoded
T5137	10235-10236	-RRB-	denotes	)
T5138	10237-10240	NN	denotes	DNA
T5123	10241-10247	NNS	denotes	probes
T5139	10247-10248	.	denotes	.
T5140	10248-10356	sentence	denotes	(C) Equal amounts of gastrocnemius muscle were collected from both transgenic mice and control littermates.
T5141	10249-10250	-LRB-	denotes	(
T5142	10250-10251	LS	denotes	C
T5144	10251-10252	-RRB-	denotes	)
T5145	10253-10258	JJ	denotes	Equal
T5146	10259-10266	NNS	denotes	amounts
T5147	10267-10269	IN	denotes	of
T5148	10270-10283	NN	denotes	gastrocnemius
T5149	10284-10290	NN	denotes	muscle
T5150	10291-10295	VBD	denotes	were
T5143	10296-10305	VBN	denotes	collected
T5151	10306-10310	IN	denotes	from
T5152	10311-10315	CC	denotes	both
T5154	10316-10326	JJ	denotes	transgenic
T5153	10327-10331	NNS	denotes	mice
T5155	10332-10335	CC	denotes	and
T5156	10336-10343	NN	denotes	control
T5157	10344-10355	NNS	denotes	littermates
T5158	10355-10356	.	denotes	.
T5159	10356-10426	sentence	denotes	Total mitochondrial DNA was isolated and separated on 1% agarose gel.
T5160	10357-10362	JJ	denotes	Total
T5162	10363-10376	JJ	denotes	mitochondrial
T5161	10377-10380	NN	denotes	DNA
T5164	10381-10384	VBD	denotes	was
T5163	10385-10393	VBN	denotes	isolated
T5165	10394-10397	CC	denotes	and
T5166	10398-10407	VBN	denotes	separated
T5167	10408-10410	IN	denotes	on
T5168	10411-10412	CD	denotes	1
T5169	10412-10413	NN	denotes	%
T5171	10414-10421	NN	denotes	agarose
T5170	10422-10425	NN	denotes	gel
T5172	10425-10426	.	denotes	.
T5173	10426-10517	sentence	denotes	The relative abundance of mitochondrial DNA in transgenic and wild-type mice is presented.
T5174	10427-10430	DT	denotes	The
T5176	10431-10439	JJ	denotes	relative
T5175	10440-10449	NN	denotes	abundance
T5178	10450-10452	IN	denotes	of
T5179	10453-10466	JJ	denotes	mitochondrial
T5180	10467-10470	NN	denotes	DNA
T5181	10471-10473	IN	denotes	in
T5182	10474-10484	JJ	denotes	transgenic
T5184	10485-10488	CC	denotes	and
T5185	10489-10493	JJ	denotes	wild
T5187	10493-10494	HYPH	denotes	-
T5186	10494-10498	NN	denotes	type
T5183	10499-10503	NNS	denotes	mice
T5188	10504-10506	VBZ	denotes	is
T5177	10507-10516	VBN	denotes	presented
T5189	10516-10517	.	denotes	.
T5190	10517-10597	sentence	denotes	(D) Western blot analysis of muscle fiber markers and mitochondrial components.
T5191	10518-10519	-LRB-	denotes	(
T5192	10519-10520	LS	denotes	D
T5194	10520-10521	-RRB-	denotes	)
T5195	10522-10529	NNP	denotes	Western
T5196	10530-10534	NN	denotes	blot
T5193	10535-10543	NN	denotes	analysis
T5197	10544-10546	IN	denotes	of
T5198	10547-10553	NN	denotes	muscle
T5199	10554-10559	NN	denotes	fiber
T5200	10560-10567	NNS	denotes	markers
T5201	10568-10571	CC	denotes	and
T5202	10572-10585	JJ	denotes	mitochondrial
T5203	10586-10596	NNS	denotes	components
T5204	10596-10597	.	denotes	.
T5205	10597-10669	sentence	denotes	Each lane was loaded with 80 μg of total gastrocnemius muscle extracts.
T5206	10598-10602	DT	denotes	Each
T5207	10603-10607	NN	denotes	lane
T5209	10608-10611	VBD	denotes	was
T5208	10612-10618	VBN	denotes	loaded
T5210	10619-10623	IN	denotes	with
T5211	10624-10626	CD	denotes	80
T5212	10627-10629	NNS	denotes	μg
T5213	10630-10632	IN	denotes	of
T5214	10633-10638	JJ	denotes	total
T5216	10639-10652	NN	denotes	gastrocnemius
T5217	10653-10659	NN	denotes	muscle
T5215	10660-10668	NNS	denotes	extracts
T5218	10668-10669	.	denotes	.
T5219	10669-10756	sentence	denotes	(E) Wild-type C57B6 mice were treated with vehicle or PPARδ agonist GW501516 for 10 d.
T5220	10670-10671	-LRB-	denotes	(
T5221	10671-10672	LS	denotes	E
T5223	10672-10673	-RRB-	denotes	)
T5224	10674-10678	JJ	denotes	Wild
T5226	10678-10679	HYPH	denotes	-
T5225	10679-10683	NN	denotes	type
T5228	10684-10689	NN	denotes	C57B6
T5227	10690-10694	NNS	denotes	mice
T5229	10695-10699	VBD	denotes	were
T5222	10700-10707	VBN	denotes	treated
T5230	10708-10712	IN	denotes	with
T5231	10713-10720	NN	denotes	vehicle
T5232	10721-10723	CC	denotes	or
T5233	10724-10729	NN	denotes	PPARδ
T5234	10730-10737	NN	denotes	agonist
T5235	10738-10746	NN	denotes	GW501516
T5236	10747-10750	IN	denotes	for
T5237	10751-10753	CD	denotes	10
T5238	10754-10755	NN	denotes	d
T5239	10755-10756	.	denotes	.
T5240	10756-10852	sentence	denotes	Total RNA (10 μg/lane) prepared from the gastrocnemius muscle was probed with indicated probes.
T5241	10757-10762	JJ	denotes	Total
T5242	10763-10766	NN	denotes	RNA
T5244	10767-10768	-LRB-	denotes	(
T5246	10768-10770	CD	denotes	10
T5245	10771-10773	NNS	denotes	μg
T5247	10773-10774	SYM	denotes	/
T5248	10774-10778	NN	denotes	lane
T5249	10778-10779	-RRB-	denotes	)
T5250	10780-10788	VBN	denotes	prepared
T5251	10789-10793	IN	denotes	from
T5252	10794-10797	DT	denotes	the
T5254	10798-10811	NN	denotes	gastrocnemius
T5253	10812-10818	NN	denotes	muscle
T5255	10819-10822	VBD	denotes	was
T5243	10823-10829	VBN	denotes	probed
T5256	10830-10834	IN	denotes	with
T5257	10835-10844	VBN	denotes	indicated
T5258	10845-10851	NNS	denotes	probes
T5259	10851-10852	.	denotes	.
T2215	10854-10860	NN	denotes	Muscle
T2216	10861-10866	NN	denotes	Fiber
T2217	10867-10873	NN	denotes	Switch
T2219	10874-10876	IN	denotes	by
T2220	10877-10882	NN	denotes	PPARδ
T2218	10883-10891	VBZ	denotes	Protects
T2221	10892-10899	IN	denotes	Against
T2222	10900-10907	NN	denotes	Obesity
T2223	10907-11091	sentence	denotes	A number of previous studies have shown that obese individuals have fewer oxidative fibers, implying that the presence of oxidative fibers alone may play a part in obesity resistance.
T2224	10908-10909	DT	denotes	A
T2225	10910-10916	NN	denotes	number
T2227	10917-10919	IN	denotes	of
T2228	10920-10928	JJ	denotes	previous
T2229	10929-10936	NNS	denotes	studies
T2230	10937-10941	VBP	denotes	have
T2226	10942-10947	VBN	denotes	shown
T2231	10948-10952	IN	denotes	that
T2233	10953-10958	JJ	denotes	obese
T2234	10959-10970	NNS	denotes	individuals
T2232	10971-10975	VBP	denotes	have
T2235	10976-10981	JJR	denotes	fewer
T2237	10982-10991	JJ	denotes	oxidative
T2236	10992-10998	NNS	denotes	fibers
T2238	10998-11000	,	denotes	,
T2239	11000-11008	VBG	denotes	implying
T2240	11009-11013	IN	denotes	that
T2242	11014-11017	DT	denotes	the
T2243	11018-11026	NN	denotes	presence
T2244	11027-11029	IN	denotes	of
T2245	11030-11039	JJ	denotes	oxidative
T2246	11040-11046	NNS	denotes	fibers
T2247	11047-11052	RB	denotes	alone
T2248	11053-11056	MD	denotes	may
T2241	11057-11061	VB	denotes	play
T2249	11062-11063	DT	denotes	a
T2250	11064-11068	NN	denotes	part
T2251	11069-11071	IN	denotes	in
T2252	11072-11079	NN	denotes	obesity
T2253	11080-11090	NN	denotes	resistance
T2254	11090-11091	.	denotes	.
T2255	11091-11207	sentence	denotes	To test this possibility, we fed the transgenic mice and their wild-type littermates with a high-fat diet for 97 d.
T2256	11092-11094	TO	denotes	To
T2257	11095-11099	VB	denotes	test
T2259	11100-11104	DT	denotes	this
T2260	11105-11116	NN	denotes	possibility
T2261	11116-11118	,	denotes	,
T2262	11118-11120	PRP	denotes	we
T2258	11121-11124	VBD	denotes	fed
T2263	11125-11128	DT	denotes	the
T2265	11129-11139	JJ	denotes	transgenic
T2264	11140-11144	NNS	denotes	mice
T2266	11145-11148	CC	denotes	and
T2267	11149-11154	PRP$	denotes	their
T2269	11155-11159	JJ	denotes	wild
T2271	11159-11160	HYPH	denotes	-
T2270	11160-11164	NN	denotes	type
T2268	11165-11176	NNS	denotes	littermates
T2272	11177-11181	IN	denotes	with
T2273	11182-11183	DT	denotes	a
T2275	11184-11188	JJ	denotes	high
T2277	11188-11189	HYPH	denotes	-
T2276	11189-11192	NN	denotes	fat
T2274	11193-11197	NN	denotes	diet
T2278	11198-11201	IN	denotes	for
T2279	11202-11204	CD	denotes	97
T2280	11205-11206	NNS	denotes	d
T2281	11206-11207	.	denotes	.
T2282	11207-11423	sentence	denotes	Although the initial body weights of the two groups were very similar, the transgenic mice had gained less than 50% at day 47, and only one-third at day 97, of the weight gained by the wild-type animals (Figure 4A).
T2283	11208-11216	IN	denotes	Although
T2285	11217-11220	DT	denotes	the
T2287	11221-11228	JJ	denotes	initial
T2288	11229-11233	NN	denotes	body
T2286	11234-11241	NNS	denotes	weights
T2289	11242-11244	IN	denotes	of
T2290	11245-11248	DT	denotes	the
T2292	11249-11252	CD	denotes	two
T2291	11253-11259	NNS	denotes	groups
T2284	11260-11264	VBD	denotes	were
T2294	11265-11269	RB	denotes	very
T2295	11270-11277	JJ	denotes	similar
T2296	11277-11279	,	denotes	,
T2297	11279-11282	DT	denotes	the
T2299	11283-11293	JJ	denotes	transgenic
T2298	11294-11298	NNS	denotes	mice
T2300	11299-11302	VBD	denotes	had
T2293	11303-11309	VBN	denotes	gained
T2301	11310-11314	JJR	denotes	less
T2303	11315-11319	IN	denotes	than
T2302	11320-11322	CD	denotes	50
T2304	11322-11323	NN	denotes	%
T2305	11324-11326	IN	denotes	at
T2306	11327-11330	NN	denotes	day
T2307	11331-11333	CD	denotes	47
T2308	11333-11335	,	denotes	,
T2309	11335-11338	CC	denotes	and
T2310	11339-11343	RB	denotes	only
T2312	11344-11347	RB	denotes	one
T2313	11347-11348	HYPH	denotes	-
T2311	11348-11353	RB	denotes	third
T2314	11354-11356	IN	denotes	at
T2315	11357-11360	NN	denotes	day
T2316	11361-11363	CD	denotes	97
T2317	11363-11365	,	denotes	,
T2318	11365-11367	IN	denotes	of
T2319	11368-11371	DT	denotes	the
T2320	11372-11378	NN	denotes	weight
T2321	11379-11385	VBN	denotes	gained
T2322	11386-11388	IN	denotes	by
T2323	11389-11392	DT	denotes	the
T2325	11393-11397	JJ	denotes	wild
T2327	11397-11398	HYPH	denotes	-
T2326	11398-11402	NN	denotes	type
T2324	11403-11410	NNS	denotes	animals
T2328	11411-11412	-LRB-	denotes	(
T2329	11412-11418	NN	denotes	Figure
T2330	11419-11421	CD	denotes	4A
T2331	11421-11422	-RRB-	denotes	)
T2332	11422-11423	.	denotes	.
T2333	11423-11563	sentence	denotes	The transgenic mice displayed significantly higher oxygen consumption on the high-fat diet than the control littermates (unpublished data).
T2334	11424-11427	DT	denotes	The
T2336	11428-11438	JJ	denotes	transgenic
T2335	11439-11443	NNS	denotes	mice
T2337	11444-11453	VBD	denotes	displayed
T2338	11454-11467	RB	denotes	significantly
T2339	11468-11474	JJR	denotes	higher
T2341	11475-11481	NN	denotes	oxygen
T2340	11482-11493	NN	denotes	consumption
T2342	11494-11496	IN	denotes	on
T2343	11497-11500	DT	denotes	the
T2345	11501-11505	JJ	denotes	high
T2347	11505-11506	HYPH	denotes	-
T2346	11506-11509	NN	denotes	fat
T2344	11510-11514	NN	denotes	diet
T2348	11515-11519	IN	denotes	than
T2349	11520-11523	DT	denotes	the
T2351	11524-11531	NN	denotes	control
T2350	11532-11543	NNS	denotes	littermates
T2352	11544-11545	-LRB-	denotes	(
T2354	11545-11556	JJ	denotes	unpublished
T2353	11557-11561	NNS	denotes	data
T2355	11561-11562	-RRB-	denotes	)
T2356	11562-11563	.	denotes	.
T2357	11563-11736	sentence	denotes	By the end of this experiment, the control littermates became obese, whereas the transgenic mice still maintained a normal body weight and fat mass composition (Figure 4A).
T2358	11564-11566	IN	denotes	By
T2360	11567-11570	DT	denotes	the
T2361	11571-11574	NN	denotes	end
T2362	11575-11577	IN	denotes	of
T2363	11578-11582	DT	denotes	this
T2364	11583-11593	NN	denotes	experiment
T2365	11593-11595	,	denotes	,
T2366	11595-11598	DT	denotes	the
T2368	11599-11606	NN	denotes	control
T2367	11607-11618	NNS	denotes	littermates
T2359	11619-11625	VBD	denotes	became
T2369	11626-11631	JJ	denotes	obese
T2370	11631-11633	,	denotes	,
T2371	11633-11640	IN	denotes	whereas
T2373	11641-11644	DT	denotes	the
T2375	11645-11655	JJ	denotes	transgenic
T2374	11656-11660	NNS	denotes	mice
T2376	11661-11666	RB	denotes	still
T2372	11667-11677	VBD	denotes	maintained
T2377	11678-11679	DT	denotes	a
T2379	11680-11686	JJ	denotes	normal
T2380	11687-11691	NN	denotes	body
T2378	11692-11698	NN	denotes	weight
T2381	11699-11702	CC	denotes	and
T2382	11703-11706	NN	denotes	fat
T2383	11707-11711	NN	denotes	mass
T2384	11712-11723	NN	denotes	composition
T2385	11724-11725	-LRB-	denotes	(
T2386	11725-11731	NN	denotes	Figure
T2387	11732-11734	CD	denotes	4A
T2388	11734-11735	-RRB-	denotes	)
T2389	11735-11736	.	denotes	.
T2390	11736-11898	sentence	denotes	A histological analysis of inguinal fat pad revealed a much smaller cell size in the transgenic mice (Figure 4B), due to the increased muscle oxidative capacity.
T2391	11737-11738	DT	denotes	A
T2393	11739-11751	JJ	denotes	histological
T2392	11752-11760	NN	denotes	analysis
T2395	11761-11763	IN	denotes	of
T2396	11764-11772	JJ	denotes	inguinal
T2398	11773-11776	NN	denotes	fat
T2397	11777-11780	NN	denotes	pad
T2394	11781-11789	VBD	denotes	revealed
T2399	11790-11791	DT	denotes	a
T2401	11792-11796	RB	denotes	much
T2402	11797-11804	JJR	denotes	smaller
T2403	11805-11809	NN	denotes	cell
T2400	11810-11814	NN	denotes	size
T2404	11815-11817	IN	denotes	in
T2405	11818-11821	DT	denotes	the
T2407	11822-11832	JJ	denotes	transgenic
T2406	11833-11837	NNS	denotes	mice
T2408	11838-11839	-LRB-	denotes	(
T2409	11839-11845	NN	denotes	Figure
T2410	11846-11848	CD	denotes	4B
T2411	11848-11849	-RRB-	denotes	)
T2412	11849-11851	,	denotes	,
T2413	11851-11854	IN	denotes	due
T2414	11855-11857	IN	denotes	to
T2415	11858-11861	DT	denotes	the
T2417	11862-11871	VBN	denotes	increased
T2418	11872-11878	NN	denotes	muscle
T2419	11879-11888	JJ	denotes	oxidative
T2416	11889-11897	NN	denotes	capacity
T2420	11897-11898	.	denotes	.
T2421	11898-12121	sentence	denotes	While there was no significant difference in intramuscular glycogen content, the triglyceride content was much less in the transgenic mice (Figure 4C and 4D), which may explain their improved glucose tolerance (Figure 4E).
T2422	11899-11904	IN	denotes	While
T2424	11905-11910	EX	denotes	there
T2423	11911-11914	VBD	denotes	was
T2426	11915-11917	DT	denotes	no
T2428	11918-11929	JJ	denotes	significant
T2427	11930-11940	NN	denotes	difference
T2429	11941-11943	IN	denotes	in
T2430	11944-11957	JJ	denotes	intramuscular
T2432	11958-11966	NN	denotes	glycogen
T2431	11967-11974	NN	denotes	content
T2433	11974-11976	,	denotes	,
T2434	11976-11979	DT	denotes	the
T2436	11980-11992	NN	denotes	triglyceride
T2435	11993-12000	NN	denotes	content
T2425	12001-12004	VBD	denotes	was
T2437	12005-12009	RB	denotes	much
T2438	12010-12014	JJR	denotes	less
T2439	12015-12017	IN	denotes	in
T2440	12018-12021	DT	denotes	the
T2442	12022-12032	JJ	denotes	transgenic
T2441	12033-12037	NNS	denotes	mice
T2443	12038-12039	-LRB-	denotes	(
T2444	12039-12045	NN	denotes	Figure
T2445	12046-12048	CD	denotes	4C
T2446	12049-12052	CC	denotes	and
T2447	12053-12055	CD	denotes	4D
T2448	12055-12056	-RRB-	denotes	)
T2449	12056-12058	,	denotes	,
T2450	12058-12063	WDT	denotes	which
T2452	12064-12067	MD	denotes	may
T2451	12068-12075	VB	denotes	explain
T2453	12076-12081	PRP$	denotes	their
T2455	12082-12090	VBN	denotes	improved
T2456	12091-12098	NN	denotes	glucose
T2454	12099-12108	NN	denotes	tolerance
T2457	12109-12110	-LRB-	denotes	(
T2458	12110-12116	NN	denotes	Figure
T2459	12117-12119	CD	denotes	4E
T2460	12119-12120	-RRB-	denotes	)
T2461	12120-12121	.	denotes	.
T2462	12121-12256	sentence	denotes	We also placed wild-type C57BJ6 mice on the high-fat diet and treated them with either vehicle or the PPARδ agonist GW501516 for 2 mo.
T2463	12122-12124	PRP	denotes	We
T2465	12125-12129	RB	denotes	also
T2464	12130-12136	VBD	denotes	placed
T2466	12137-12141	JJ	denotes	wild
T2468	12141-12142	HYPH	denotes	-
T2467	12142-12146	NN	denotes	type
T2470	12147-12153	NN	denotes	C57BJ6
T2469	12154-12158	NNS	denotes	mice
T2471	12159-12161	IN	denotes	on
T2472	12162-12165	DT	denotes	the
T2474	12166-12170	JJ	denotes	high
T2476	12170-12171	HYPH	denotes	-
T2475	12171-12174	NN	denotes	fat
T2473	12175-12179	NN	denotes	diet
T2477	12180-12183	CC	denotes	and
T2478	12184-12191	VBN	denotes	treated
T2479	12192-12196	PRP	denotes	them
T2480	12197-12201	IN	denotes	with
T2481	12202-12208	CC	denotes	either
T2482	12209-12216	NN	denotes	vehicle
T2483	12217-12219	CC	denotes	or
T2484	12220-12223	DT	denotes	the
T2486	12224-12229	NN	denotes	PPARδ
T2487	12230-12237	NN	denotes	agonist
T2485	12238-12246	NN	denotes	GW501516
T2488	12247-12250	IN	denotes	for
T2489	12251-12252	CD	denotes	2
T2490	12253-12255	NN	denotes	mo
T2491	12255-12256	.	denotes	.
T2492	12256-12528	sentence	denotes	GW501516 produced a sustained induction of genes for type I muscle fibers; this, at least in part, resulted in an only 30% gain in body weight, a dramatically reduced fat mass accumulation, and improved glucose tolerance, compared to the vehicle-treated group (Figure 5).
T2493	12257-12265	NN	denotes	GW501516
T2494	12266-12274	VBD	denotes	produced
T2496	12275-12276	DT	denotes	a
T2498	12277-12286	VBN	denotes	sustained
T2497	12287-12296	NN	denotes	induction
T2499	12297-12299	IN	denotes	of
T2500	12300-12305	NNS	denotes	genes
T2501	12306-12309	IN	denotes	for
T2502	12310-12314	NN	denotes	type
T2504	12315-12316	CD	denotes	I
T2505	12317-12323	NN	denotes	muscle
T2503	12324-12330	NNS	denotes	fibers
T2506	12330-12331	:	denotes	;
T2507	12332-12336	DT	denotes	this
T2508	12336-12338	,	denotes	,
T2509	12338-12340	RB	denotes	at
T2510	12341-12346	RBS	denotes	least
T2511	12347-12349	IN	denotes	in
T2512	12350-12354	JJ	denotes	part
T2513	12354-12356	,	denotes	,
T2495	12356-12364	VBD	denotes	resulted
T2514	12365-12367	IN	denotes	in
T2515	12368-12370	DT	denotes	an
T2517	12371-12375	RB	denotes	only
T2518	12376-12378	CD	denotes	30
T2519	12378-12379	NN	denotes	%
T2516	12380-12384	NN	denotes	gain
T2520	12385-12387	IN	denotes	in
T2521	12388-12392	NN	denotes	body
T2522	12393-12399	NN	denotes	weight
T2523	12399-12401	,	denotes	,
T2524	12401-12402	DT	denotes	a
T2526	12403-12415	RB	denotes	dramatically
T2527	12416-12423	VBN	denotes	reduced
T2528	12424-12427	NN	denotes	fat
T2529	12428-12432	NN	denotes	mass
T2525	12433-12445	NN	denotes	accumulation
T2530	12445-12447	,	denotes	,
T2531	12447-12450	CC	denotes	and
T2532	12451-12459	VBN	denotes	improved
T2534	12460-12467	NN	denotes	glucose
T2533	12468-12477	NN	denotes	tolerance
T2535	12477-12479	,	denotes	,
T2536	12479-12487	VBN	denotes	compared
T2537	12488-12490	IN	denotes	to
T2538	12491-12494	DT	denotes	the
T2540	12495-12502	NN	denotes	vehicle
T2542	12502-12503	HYPH	denotes	-
T2541	12503-12510	VBN	denotes	treated
T2539	12511-12516	NN	denotes	group
T2543	12517-12518	-LRB-	denotes	(
T2544	12518-12524	NN	denotes	Figure
T2545	12525-12526	CD	denotes	5
T2546	12526-12527	-RRB-	denotes	)
T2547	12527-12528	.	denotes	.
T2548	12528-12662	sentence	denotes	Thus, muscle fiber conversion by stimulation with the PPARδ agonist or the activated transgene has a protective role against obesity.
T2549	12529-12533	RB	denotes	Thus
T2551	12533-12535	,	denotes	,
T2552	12535-12541	NN	denotes	muscle
T2553	12542-12547	NN	denotes	fiber
T2554	12548-12558	NN	denotes	conversion
T2555	12559-12561	IN	denotes	by
T2556	12562-12573	NN	denotes	stimulation
T2557	12574-12578	IN	denotes	with
T2558	12579-12582	DT	denotes	the
T2560	12583-12588	NN	denotes	PPARδ
T2559	12589-12596	NN	denotes	agonist
T2561	12597-12599	CC	denotes	or
T2562	12600-12603	DT	denotes	the
T2564	12604-12613	VBN	denotes	activated
T2563	12614-12623	NN	denotes	transgene
T2550	12624-12627	VBZ	denotes	has
T2565	12628-12629	DT	denotes	a
T2567	12630-12640	JJ	denotes	protective
T2566	12641-12645	NN	denotes	role
T2568	12646-12653	IN	denotes	against
T2569	12654-12661	NN	denotes	obesity
T2570	12661-12662	.	denotes	.
T5308	12673-12683	NN	denotes	Resistance
T5309	12684-12686	IN	denotes	to
T5310	12687-12691	JJ	denotes	High
T5312	12691-12692	HYPH	denotes	-
T5311	12692-12695	NN	denotes	Fat
T5314	12695-12696	HYPH	denotes	-
T5313	12696-12703	VBN	denotes	Induced
T5315	12704-12711	NN	denotes	Obesity
T5316	12712-12714	IN	denotes	in
T5317	12715-12718	DT	denotes	the
T5319	12719-12729	JJ	denotes	Transgenic
T5318	12730-12734	NNS	denotes	Mice
T5320	12734-12865	sentence	denotes	(A) Seven-week-old transgenic (TG) and wild-type (WT) littermates (n = 5–6 for each group) were fed with a high-fat diet for 97 d.
T5321	12735-12736	-LRB-	denotes	(
T5322	12736-12737	LS	denotes	A
T5324	12737-12738	-RRB-	denotes	)
T5325	12739-12744	CD	denotes	Seven
T5327	12744-12745	HYPH	denotes	-
T5326	12745-12749	NN	denotes	week
T5329	12749-12750	HYPH	denotes	-
T5328	12750-12753	JJ	denotes	old
T5331	12754-12764	JJ	denotes	transgenic
T5332	12765-12766	-LRB-	denotes	(
T5333	12766-12768	JJ	denotes	TG
T5334	12768-12769	-RRB-	denotes	)
T5335	12770-12773	CC	denotes	and
T5336	12774-12778	JJ	denotes	wild
T5338	12778-12779	HYPH	denotes	-
T5337	12779-12783	NN	denotes	type
T5339	12784-12785	-LRB-	denotes	(
T5340	12785-12787	NN	denotes	WT
T5341	12787-12788	-RRB-	denotes	)
T5330	12789-12800	NNS	denotes	littermates
T5342	12801-12802	-LRB-	denotes	(
T5344	12802-12803	NN	denotes	n
T5345	12804-12805	SYM	denotes	=
T5346	12806-12807	CD	denotes	5
T5347	12807-12808	SYM	denotes	–
T5343	12808-12809	CD	denotes	6
T5348	12810-12813	IN	denotes	for
T5349	12814-12818	DT	denotes	each
T5350	12819-12824	NN	denotes	group
T5351	12824-12825	-RRB-	denotes	)
T5352	12826-12830	VBD	denotes	were
T5323	12831-12834	VBN	denotes	fed
T5353	12835-12839	IN	denotes	with
T5354	12840-12841	DT	denotes	a
T5356	12842-12846	JJ	denotes	high
T5358	12846-12847	HYPH	denotes	-
T5357	12847-12850	NN	denotes	fat
T5355	12851-12855	NN	denotes	diet
T5359	12856-12859	IN	denotes	for
T5360	12860-12862	CD	denotes	97
T5361	12863-12864	NN	denotes	d
T5362	12864-12865	.	denotes	.
T5363	12865-12964	sentence	denotes	Left panel shows net body weight gain, which was calculated for individual mice and then averaged.
T5364	12866-12870	JJ	denotes	Left
T5365	12871-12876	NN	denotes	panel
T5366	12877-12882	VBZ	denotes	shows
T5367	12883-12886	JJ	denotes	net
T5369	12887-12891	NN	denotes	body
T5370	12892-12898	NN	denotes	weight
T5368	12899-12903	NN	denotes	gain
T5371	12903-12905	,	denotes	,
T5372	12905-12910	WDT	denotes	which
T5374	12911-12914	VBD	denotes	was
T5373	12915-12925	VBN	denotes	calculated
T5375	12926-12929	IN	denotes	for
T5376	12930-12940	JJ	denotes	individual
T5377	12941-12945	NNS	denotes	mice
T5378	12946-12949	CC	denotes	and
T5379	12950-12954	RB	denotes	then
T5380	12955-12963	VBN	denotes	averaged
T5381	12963-12964	.	denotes	.
T5382	12964-13051	sentence	denotes	Right panel shows the body weights before (Day 0) and after (Day 97) high-fat feeding.
T5383	12965-12970	JJ	denotes	Right
T5384	12971-12976	NN	denotes	panel
T5385	12977-12982	VBZ	denotes	shows
T5386	12983-12986	DT	denotes	the
T5388	12987-12991	NN	denotes	body
T5387	12992-12999	NNS	denotes	weights
T5389	13000-13006	IN	denotes	before
T5390	13007-13008	-LRB-	denotes	(
T5391	13008-13011	NN	denotes	Day
T5392	13012-13013	CD	denotes	0
T5393	13013-13014	-RRB-	denotes	)
T5394	13015-13018	CC	denotes	and
T5395	13019-13024	IN	denotes	after
T5396	13025-13026	-LRB-	denotes	(
T5397	13026-13029	NN	denotes	Day
T5398	13030-13032	CD	denotes	97
T5399	13032-13033	-RRB-	denotes	)
T5400	13034-13038	JJ	denotes	high
T5402	13038-13039	HYPH	denotes	-
T5401	13039-13042	NN	denotes	fat
T5403	13043-13050	NN	denotes	feeding
T5404	13050-13051	.	denotes	.
T5405	13051-13161	sentence	denotes	(B) Histology of inguinal fat pad in the transgenic and wild-type littermates under a high-fat diet for 2 mo.
T5406	13052-13053	-LRB-	denotes	(
T5407	13053-13054	LS	denotes	B
T5409	13054-13055	-RRB-	denotes	)
T5408	13056-13065	NN	denotes	Histology
T5410	13066-13068	IN	denotes	of
T5411	13069-13077	JJ	denotes	inguinal
T5413	13078-13081	NN	denotes	fat
T5412	13082-13085	NN	denotes	pad
T5414	13086-13088	IN	denotes	in
T5415	13089-13092	DT	denotes	the
T5417	13093-13103	JJ	denotes	transgenic
T5418	13104-13107	CC	denotes	and
T5419	13108-13112	JJ	denotes	wild
T5421	13112-13113	HYPH	denotes	-
T5420	13113-13117	NN	denotes	type
T5416	13118-13129	NNS	denotes	littermates
T5422	13130-13135	IN	denotes	under
T5423	13136-13137	DT	denotes	a
T5425	13138-13142	JJ	denotes	high
T5427	13142-13143	HYPH	denotes	-
T5426	13143-13146	NN	denotes	fat
T5424	13147-13151	NN	denotes	diet
T5428	13152-13155	IN	denotes	for
T5429	13156-13157	CD	denotes	2
T5430	13158-13160	NN	denotes	mo
T5431	13160-13161	.	denotes	.
T5432	13161-13282	sentence	denotes	(C and D) Intramuscular glycogen content (C) and triglyceride content (D) of mice in (A) after high-fat feeding (n = 6).
T5433	13162-13163	-LRB-	denotes	(
T5434	13163-13164	LS	denotes	C
T5436	13165-13168	CC	denotes	and
T5437	13169-13170	LS	denotes	D
T5438	13170-13171	-RRB-	denotes	)
T5439	13172-13185	JJ	denotes	Intramuscular
T5440	13186-13194	NN	denotes	glycogen
T5435	13195-13202	NN	denotes	content
T5441	13203-13204	-LRB-	denotes	(
T5442	13204-13205	NN	denotes	C
T5443	13205-13206	-RRB-	denotes	)
T5444	13207-13210	CC	denotes	and
T5445	13211-13223	NN	denotes	triglyceride
T5446	13224-13231	NN	denotes	content
T5447	13232-13233	-LRB-	denotes	(
T5448	13233-13234	NN	denotes	D
T5449	13234-13235	-RRB-	denotes	)
T5450	13236-13238	IN	denotes	of
T5451	13239-13243	NNS	denotes	mice
T5452	13244-13246	IN	denotes	in
T5453	13247-13248	-LRB-	denotes	(
T5454	13248-13249	NN	denotes	A
T5455	13249-13250	-RRB-	denotes	)
T5456	13251-13256	IN	denotes	after
T5457	13257-13261	JJ	denotes	high
T5459	13261-13262	HYPH	denotes	-
T5458	13262-13265	NN	denotes	fat
T5460	13266-13273	NN	denotes	feeding
T5461	13274-13275	-LRB-	denotes	(
T5463	13275-13276	NN	denotes	n
T5464	13277-13278	SYM	denotes	=
T5462	13279-13280	CD	denotes	6
T5465	13280-13281	-RRB-	denotes	)
T5466	13281-13282	.	denotes	.
T5467	13282-13310	sentence	denotes	(E) Glucose tolerance test.
T5468	13283-13284	-LRB-	denotes	(
T5469	13284-13285	LS	denotes	E
T5471	13285-13286	-RRB-	denotes	)
T5472	13287-13294	NN	denotes	Glucose
T5473	13295-13304	NN	denotes	tolerance
T5470	13305-13309	NN	denotes	test
T5474	13309-13310	.	denotes	.
T5475	13310-13437	sentence	denotes	Mice in (A) after high-fat feeding were fasted for 6 h and then injected with glucose at a concentration of 1g/kg body weight.
T5476	13311-13315	NNS	denotes	Mice
T5478	13316-13318	IN	denotes	in
T5479	13319-13320	-LRB-	denotes	(
T5480	13320-13321	NN	denotes	A
T5481	13321-13322	-RRB-	denotes	)
T5482	13323-13328	IN	denotes	after
T5483	13329-13333	JJ	denotes	high
T5485	13333-13334	HYPH	denotes	-
T5484	13334-13337	NN	denotes	fat
T5486	13338-13345	NN	denotes	feeding
T5487	13346-13350	VBD	denotes	were
T5477	13351-13357	VBN	denotes	fasted
T5488	13358-13361	IN	denotes	for
T5489	13362-13363	CD	denotes	6
T5490	13364-13365	NN	denotes	h
T5491	13366-13369	CC	denotes	and
T5492	13370-13374	RB	denotes	then
T5493	13375-13383	VBN	denotes	injected
T5494	13384-13388	IN	denotes	with
T5495	13389-13396	NN	denotes	glucose
T5496	13397-13399	IN	denotes	at
T5497	13400-13401	DT	denotes	a
T5498	13402-13415	NN	denotes	concentration
T5499	13416-13418	IN	denotes	of
T5500	13419-13421	NN	denotes	1g
T5501	13421-13422	SYM	denotes	/
T5503	13422-13424	NN	denotes	kg
T5504	13425-13429	NN	denotes	body
T5502	13430-13436	NN	denotes	weight
T5505	13436-13437	.	denotes	.
T5506	13437-13508	sentence	denotes	Then blood glucose levels were measured periodically over 2 h (n = 6).
T5507	13438-13442	RB	denotes	Then
T5509	13443-13448	NN	denotes	blood
T5510	13449-13456	NN	denotes	glucose
T5511	13457-13463	NNS	denotes	levels
T5512	13464-13468	VBD	denotes	were
T5508	13469-13477	VBN	denotes	measured
T5513	13478-13490	RB	denotes	periodically
T5514	13491-13495	IN	denotes	over
T5515	13496-13497	CD	denotes	2
T5516	13498-13499	NN	denotes	h
T5517	13500-13501	-LRB-	denotes	(
T5519	13501-13502	NN	denotes	n
T5520	13503-13504	SYM	denotes	=
T5518	13505-13506	CD	denotes	6
T5521	13506-13507	-RRB-	denotes	)
T5522	13507-13508	.	denotes	.
T5573	13519-13524	NN	denotes	PPARδ
T5574	13525-13533	NNS	denotes	Agonists
T5575	13534-13544	VBP	denotes	Counteract
T5576	13545-13552	NN	denotes	Obesity
T5577	13553-13560	VBN	denotes	Induced
T5578	13561-13563	IN	denotes	by
T5579	13564-13568	JJ	denotes	High
T5581	13568-13569	HYPH	denotes	-
T5580	13569-13572	NN	denotes	Fat
T5582	13573-13577	NN	denotes	Diet
T5583	13577-13693	sentence	denotes	(A) Eleven-week-old wild-type C57B6 mice were fed a high-fat diet in combination with vehicle or GW501516 for 57 d.
T5584	13578-13579	-LRB-	denotes	(
T5585	13579-13580	LS	denotes	A
T5587	13580-13581	-RRB-	denotes	)
T5588	13582-13588	CD	denotes	Eleven
T5590	13588-13589	HYPH	denotes	-
T5589	13589-13593	NN	denotes	week
T5592	13593-13594	HYPH	denotes	-
T5591	13594-13597	JJ	denotes	old
T5594	13598-13602	JJ	denotes	wild
T5596	13602-13603	HYPH	denotes	-
T5595	13603-13607	NN	denotes	type
T5597	13608-13613	NN	denotes	C57B6
T5593	13614-13618	NNS	denotes	mice
T5598	13619-13623	VBD	denotes	were
T5586	13624-13627	VBN	denotes	fed
T5599	13628-13629	DT	denotes	a
T5601	13630-13634	JJ	denotes	high
T5603	13634-13635	HYPH	denotes	-
T5602	13635-13638	NN	denotes	fat
T5600	13639-13643	NN	denotes	diet
T5604	13644-13646	IN	denotes	in
T5605	13647-13658	NN	denotes	combination
T5606	13659-13663	IN	denotes	with
T5607	13664-13671	NN	denotes	vehicle
T5608	13672-13674	CC	denotes	or
T5609	13675-13683	NN	denotes	GW501516
T5610	13684-13687	IN	denotes	for
T5611	13688-13690	CD	denotes	57
T5612	13691-13692	NN	denotes	d
T5613	13692-13693	.	denotes	.
T5614	13693-13789	sentence	denotes	Total RNA (10 μg/lane) prepared from the gastrocnemius muscle was probed with indicated probes.
T5615	13694-13699	JJ	denotes	Total
T5616	13700-13703	NN	denotes	RNA
T5618	13704-13705	-LRB-	denotes	(
T5620	13705-13707	CD	denotes	10
T5619	13708-13710	NNS	denotes	μg
T5621	13710-13711	SYM	denotes	/
T5622	13711-13715	NN	denotes	lane
T5623	13715-13716	-RRB-	denotes	)
T5624	13717-13725	VBN	denotes	prepared
T5625	13726-13730	IN	denotes	from
T5626	13731-13734	DT	denotes	the
T5628	13735-13748	NN	denotes	gastrocnemius
T5627	13749-13755	NN	denotes	muscle
T5629	13756-13759	VBD	denotes	was
T5617	13760-13766	VBN	denotes	probed
T5630	13767-13771	IN	denotes	with
T5631	13772-13781	VBN	denotes	indicated
T5632	13782-13788	NNS	denotes	probes
T5633	13788-13789	.	denotes	.
T5634	13789-13895	sentence	denotes	(B) Net body weight gain for mice in (A) after treatment was calculated for individual mice and averaged.
T5635	13790-13791	-LRB-	denotes	(
T5636	13791-13792	LS	denotes	B
T5638	13792-13793	-RRB-	denotes	)
T5639	13794-13797	JJ	denotes	Net
T5641	13798-13802	NN	denotes	body
T5642	13803-13809	NN	denotes	weight
T5640	13810-13814	NN	denotes	gain
T5643	13815-13818	IN	denotes	for
T5644	13819-13823	NNS	denotes	mice
T5645	13824-13826	IN	denotes	in
T5646	13827-13828	-LRB-	denotes	(
T5647	13828-13829	NN	denotes	A
T5648	13829-13830	-RRB-	denotes	)
T5649	13831-13836	IN	denotes	after
T5650	13837-13846	NN	denotes	treatment
T5651	13847-13850	VBD	denotes	was
T5637	13851-13861	VBN	denotes	calculated
T5652	13862-13865	IN	denotes	for
T5653	13866-13876	JJ	denotes	individual
T5654	13877-13881	NNS	denotes	mice
T5655	13882-13885	CC	denotes	and
T5656	13886-13894	VBN	denotes	averaged
T5657	13894-13895	.	denotes	.
T5658	13895-14009	sentence	denotes	Initial body weights were 28.54 ± 1.04 g for vehicle group (n = 5) and 28.86 ± 0.80 g for GW501516 group (n = 5).
T5659	13896-13903	JJ	denotes	Initial
T5661	13904-13908	NN	denotes	body
T5660	13909-13916	NNS	denotes	weights
T5662	13917-13921	VBD	denotes	were
T5663	13922-13927	CD	denotes	28.54
T5665	13928-13929	SYM	denotes	±
T5664	13930-13934	CD	denotes	1.04
T5666	13935-13936	NNS	denotes	g
T5667	13937-13940	IN	denotes	for
T5668	13941-13948	NN	denotes	vehicle
T5669	13949-13954	NN	denotes	group
T5670	13955-13956	-LRB-	denotes	(
T5672	13956-13957	NN	denotes	n
T5673	13958-13959	SYM	denotes	=
T5671	13960-13961	CD	denotes	5
T5674	13961-13962	-RRB-	denotes	)
T5675	13963-13966	CC	denotes	and
T5676	13967-13972	CD	denotes	28.86
T5678	13973-13974	SYM	denotes	±
T5677	13975-13979	CD	denotes	0.80
T5679	13980-13981	NNS	denotes	g
T5680	13982-13985	IN	denotes	for
T5681	13986-13994	NN	denotes	GW501516
T5682	13995-14000	NN	denotes	group
T5683	14001-14002	-LRB-	denotes	(
T5685	14002-14003	NN	denotes	n
T5686	14004-14005	SYM	denotes	=
T5684	14006-14007	CD	denotes	5
T5687	14007-14008	-RRB-	denotes	)
T5688	14008-14009	.	denotes	.
T5689	14009-14069	sentence	denotes	(C) Various tissue weights for mice in (A) after treatment.
T5690	14010-14011	-LRB-	denotes	(
T5691	14011-14012	LS	denotes	C
T5693	14012-14013	-RRB-	denotes	)
T5694	14014-14021	JJ	denotes	Various
T5695	14022-14028	NN	denotes	tissue
T5692	14029-14036	NNS	denotes	weights
T5696	14037-14040	IN	denotes	for
T5697	14041-14045	NNS	denotes	mice
T5698	14046-14048	IN	denotes	in
T5699	14049-14050	-LRB-	denotes	(
T5700	14050-14051	NN	denotes	A
T5701	14051-14052	-RRB-	denotes	)
T5702	14053-14058	IN	denotes	after
T5703	14059-14068	NN	denotes	treatment
T5704	14068-14069	.	denotes	.
T5705	14069-14145	sentence	denotes	ifat, inguinal fat; rdfat, reproductive fat; retrofat, retroperitoneal fat.
T5706	14070-14074	NN	denotes	ifat
T5707	14074-14076	,	denotes	,
T5708	14076-14084	JJ	denotes	inguinal
T5709	14085-14088	NN	denotes	fat
T5710	14088-14089	,	denotes	;
T5711	14090-14095	NN	denotes	rdfat
T5712	14095-14097	,	denotes	,
T5713	14097-14109	JJ	denotes	reproductive
T5714	14110-14113	NN	denotes	fat
T5715	14113-14114	,	denotes	;
T5716	14115-14123	NN	denotes	retrofat
T5717	14123-14125	,	denotes	,
T5718	14125-14140	JJ	denotes	retroperitoneal
T5719	14141-14144	NN	denotes	fat
T5720	14144-14145	.	denotes	.
T5721	14145-14173	sentence	denotes	(D) Glucose tolerance test.
T5722	14146-14147	-LRB-	denotes	(
T5723	14147-14148	LS	denotes	D
T5725	14148-14149	-RRB-	denotes	)
T5726	14150-14157	NN	denotes	Glucose
T5727	14158-14167	NN	denotes	tolerance
T5724	14168-14172	NN	denotes	test
T5728	14172-14173	.	denotes	.
T5729	14173-14293	sentence	denotes	Mice in (A) after treatment were fasted for 6 h and then injected with glucose at a concentration of 1g/kg body weight.
T5730	14174-14178	NNS	denotes	Mice
T5732	14179-14181	IN	denotes	in
T5733	14182-14183	-LRB-	denotes	(
T5734	14183-14184	NN	denotes	A
T5735	14184-14185	-RRB-	denotes	)
T5736	14186-14191	IN	denotes	after
T5737	14192-14201	NN	denotes	treatment
T5738	14202-14206	VBD	denotes	were
T5731	14207-14213	VBN	denotes	fasted
T5739	14214-14217	IN	denotes	for
T5740	14218-14219	CD	denotes	6
T5741	14220-14221	NN	denotes	h
T5742	14222-14225	CC	denotes	and
T5743	14226-14230	RB	denotes	then
T5744	14231-14239	VBN	denotes	injected
T5745	14240-14244	IN	denotes	with
T5746	14245-14252	NN	denotes	glucose
T5747	14253-14255	IN	denotes	at
T5748	14256-14257	DT	denotes	a
T5749	14258-14271	NN	denotes	concentration
T5750	14272-14274	IN	denotes	of
T5751	14275-14277	NN	denotes	1g
T5752	14277-14278	SYM	denotes	/
T5754	14278-14280	NN	denotes	kg
T5755	14281-14285	NN	denotes	body
T5753	14286-14292	NN	denotes	weight
T5756	14292-14293	.	denotes	.
T5757	14293-14356	sentence	denotes	Blood glucose levels were then measured periodically over 2 h.
T5758	14294-14299	NN	denotes	Blood
T5759	14300-14307	NN	denotes	glucose
T5760	14308-14314	NNS	denotes	levels
T5762	14315-14319	VBD	denotes	were
T5763	14320-14324	RB	denotes	then
T5761	14325-14333	VBN	denotes	measured
T5764	14334-14346	RB	denotes	periodically
T5765	14347-14351	IN	denotes	over
T5766	14352-14353	CD	denotes	2
T5767	14354-14355	NN	denotes	h
T5768	14355-14356	.	denotes	.
T2626	14358-14368	NN	denotes	Activation
T2628	14369-14371	IN	denotes	of
T2629	14372-14377	NN	denotes	PPARδ
T2627	14378-14386	VBZ	denotes	Enhances
T2630	14387-14395	JJ	denotes	Physical
T2631	14396-14407	NN	denotes	Performance
T2632	14407-14492	sentence	denotes	Muscle oxidative capacity is a crucial factor for determining endurance and fatigue.
T2633	14408-14414	NN	denotes	Muscle
T2635	14415-14424	JJ	denotes	oxidative
T2634	14425-14433	NN	denotes	capacity
T2636	14434-14436	VBZ	denotes	is
T2637	14437-14438	DT	denotes	a
T2639	14439-14446	JJ	denotes	crucial
T2638	14447-14453	NN	denotes	factor
T2640	14454-14457	IN	denotes	for
T2641	14458-14469	VBG	denotes	determining
T2642	14470-14479	NN	denotes	endurance
T2643	14480-14483	CC	denotes	and
T2644	14484-14491	NN	denotes	fatigue
T2645	14491-14492	.	denotes	.
T2646	14492-14601	sentence	denotes	Indeed, type I fibers adaptively generated through exercise training are considered to be fatigue resistant.
T2647	14493-14499	RB	denotes	Indeed
T2649	14499-14501	,	denotes	,
T2650	14501-14505	NN	denotes	type
T2652	14506-14507	CD	denotes	I
T2651	14508-14514	NNS	denotes	fibers
T2653	14515-14525	RB	denotes	adaptively
T2654	14526-14535	VBN	denotes	generated
T2655	14536-14543	IN	denotes	through
T2656	14544-14552	NN	denotes	exercise
T2657	14553-14561	NN	denotes	training
T2658	14562-14565	VBP	denotes	are
T2648	14566-14576	VBN	denotes	considered
T2659	14577-14579	TO	denotes	to
T2660	14580-14582	VB	denotes	be
T2661	14583-14590	NN	denotes	fatigue
T2662	14591-14600	JJ	denotes	resistant
T2663	14600-14601	.	denotes	.
T2664	14601-14766	sentence	denotes	However, whether the type I fibers generated molecularly via PPARδ expression can contribute to enhanced performance in the absence of previous training is unclear.
T2665	14602-14609	RB	denotes	However
T2667	14609-14611	,	denotes	,
T2668	14611-14618	IN	denotes	whether
T2670	14619-14622	DT	denotes	the
T2672	14623-14627	NN	denotes	type
T2673	14628-14629	CD	denotes	I
T2671	14630-14636	NNS	denotes	fibers
T2674	14637-14646	VBN	denotes	generated
T2675	14647-14658	RB	denotes	molecularly
T2676	14659-14662	IN	denotes	via
T2677	14663-14668	NN	denotes	PPARδ
T2678	14669-14679	NN	denotes	expression
T2679	14680-14683	MD	denotes	can
T2669	14684-14694	VB	denotes	contribute
T2680	14695-14697	IN	denotes	to
T2681	14698-14706	VBN	denotes	enhanced
T2682	14707-14718	NN	denotes	performance
T2683	14719-14721	IN	denotes	in
T2684	14722-14725	DT	denotes	the
T2685	14726-14733	NN	denotes	absence
T2686	14734-14736	IN	denotes	of
T2687	14737-14745	JJ	denotes	previous
T2688	14746-14754	NN	denotes	training
T2666	14755-14757	VBZ	denotes	is
T2689	14758-14765	JJ	denotes	unclear
T2690	14765-14766	.	denotes	.
T2691	14766-14890	sentence	denotes	In fact, the consequence of genetically induced fiber switch on running capacity has to our knowledge never been evaluated.
T2692	14767-14769	IN	denotes	In
T2694	14770-14774	NN	denotes	fact
T2695	14774-14776	,	denotes	,
T2696	14776-14779	DT	denotes	the
T2697	14780-14791	NN	denotes	consequence
T2698	14792-14794	IN	denotes	of
T2699	14795-14806	RB	denotes	genetically
T2700	14807-14814	VBN	denotes	induced
T2702	14815-14820	NN	denotes	fiber
T2701	14821-14827	NN	denotes	switch
T2703	14828-14830	IN	denotes	on
T2704	14831-14838	VBG	denotes	running
T2705	14839-14847	NN	denotes	capacity
T2706	14848-14851	VBZ	denotes	has
T2707	14852-14854	IN	denotes	to
T2708	14855-14858	PRP$	denotes	our
T2709	14859-14868	NN	denotes	knowledge
T2710	14869-14874	RB	denotes	never
T2711	14875-14879	VBN	denotes	been
T2693	14880-14889	VBN	denotes	evaluated
T2712	14889-14890	.	denotes	.
T2713	14890-15005	sentence	denotes	We thus compared exercise performance between untrained, body-weight-matched transgenic and wild-type littermates.
T2714	14891-14893	PRP	denotes	We
T2716	14894-14898	RB	denotes	thus
T2715	14899-14907	VBD	denotes	compared
T2717	14908-14916	NN	denotes	exercise
T2718	14917-14928	NN	denotes	performance
T2719	14929-14936	IN	denotes	between
T2720	14937-14946	JJ	denotes	untrained
T2722	14946-14948	,	denotes	,
T2723	14948-14952	NN	denotes	body
T2725	14952-14953	HYPH	denotes	-
T2724	14953-14959	NN	denotes	weight
T2727	14959-14960	HYPH	denotes	-
T2726	14960-14967	VBN	denotes	matched
T2728	14968-14978	JJ	denotes	transgenic
T2729	14979-14982	CC	denotes	and
T2730	14983-14987	JJ	denotes	wild
T2732	14987-14988	HYPH	denotes	-
T2731	14988-14992	NN	denotes	type
T2721	14993-15004	NNS	denotes	littermates
T2733	15004-15005	.	denotes	.
T2734	15005-15076	sentence	denotes	Mice were run on oxygen-infused, enclosed treadmills until exhaustion.
T2735	15006-15010	NNS	denotes	Mice
T2737	15011-15015	VBD	denotes	were
T2736	15016-15019	VBN	denotes	run
T2738	15020-15022	IN	denotes	on
T2739	15023-15029	NN	denotes	oxygen
T2741	15029-15030	HYPH	denotes	-
T2740	15030-15037	VBN	denotes	infused
T2743	15037-15039	,	denotes	,
T2744	15039-15047	VBN	denotes	enclosed
T2742	15048-15058	NNS	denotes	treadmills
T2745	15059-15064	IN	denotes	until
T2746	15065-15075	NN	denotes	exhaustion
T2747	15075-15076	.	denotes	.
T2748	15076-15243	sentence	denotes	Strikingly, the running time and distance the transgenic mice were able to sustain were increased by 67% and 92%, respectively (Figure 6A; also see Videos S1 and S2).
T2749	15077-15087	RB	denotes	Strikingly
T2751	15087-15089	,	denotes	,
T2752	15089-15092	DT	denotes	the
T2754	15093-15100	NN	denotes	running
T2753	15101-15105	NN	denotes	time
T2755	15106-15109	CC	denotes	and
T2756	15110-15118	NN	denotes	distance
T2757	15119-15122	DT	denotes	the
T2759	15123-15133	JJ	denotes	transgenic
T2758	15134-15138	NNS	denotes	mice
T2760	15139-15143	VBD	denotes	were
T2761	15144-15148	JJ	denotes	able
T2762	15149-15151	TO	denotes	to
T2763	15152-15159	VB	denotes	sustain
T2764	15160-15164	VBD	denotes	were
T2750	15165-15174	VBN	denotes	increased
T2765	15175-15177	IN	denotes	by
T2766	15178-15180	CD	denotes	67
T2767	15180-15181	NN	denotes	%
T2768	15182-15185	CC	denotes	and
T2769	15186-15188	CD	denotes	92
T2770	15188-15189	NN	denotes	%
T2771	15189-15191	,	denotes	,
T2772	15191-15203	RB	denotes	respectively
T2773	15204-15205	-LRB-	denotes	(
T2774	15205-15211	NN	denotes	Figure
T2775	15212-15214	CD	denotes	6A
T2776	15214-15215	:	denotes	;
T2777	15216-15220	RB	denotes	also
T2778	15221-15224	VB	denotes	see
T2779	15225-15231	NNS	denotes	Videos
T2780	15232-15234	NN	denotes	S1
T2781	15235-15238	CC	denotes	and
T2782	15239-15241	NN	denotes	S2
T2783	15241-15242	-RRB-	denotes	)
T2784	15242-15243	.	denotes	.
T2785	15243-15351	sentence	denotes	The transgenic mice ran about 1 h longer than the controls, which translates to nearly a kilometer further.
T2786	15244-15247	DT	denotes	The
T2788	15248-15258	JJ	denotes	transgenic
T2787	15259-15263	NNS	denotes	mice
T2789	15264-15267	VBD	denotes	ran
T2790	15268-15273	RB	denotes	about
T2791	15274-15275	CD	denotes	1
T2792	15276-15277	NN	denotes	h
T2793	15278-15284	RBR	denotes	longer
T2794	15285-15289	IN	denotes	than
T2795	15290-15293	DT	denotes	the
T2796	15294-15302	NNS	denotes	controls
T2797	15302-15304	,	denotes	,
T2798	15304-15309	WDT	denotes	which
T2799	15310-15320	VBZ	denotes	translates
T2800	15321-15323	IN	denotes	to
T2801	15324-15330	RB	denotes	nearly
T2802	15331-15332	DT	denotes	a
T2803	15333-15342	NN	denotes	kilometer
T2804	15343-15350	RBR	denotes	further
T2805	15350-15351	.	denotes	.
T2806	15351-15598	sentence	denotes	No significant differences in muscle mass (unpublished data) and daily activity (total counts of activity per hour: 1618 ± 209 for transgenic versus 1987 ± 301 for wild-type, p > 0.35, n = 4) were observed between the transgenic and control mice.
T2807	15352-15354	DT	denotes	No
T2809	15355-15366	JJ	denotes	significant
T2808	15367-15378	NNS	denotes	differences
T2811	15379-15381	IN	denotes	in
T2812	15382-15388	NN	denotes	muscle
T2813	15389-15393	NN	denotes	mass
T2814	15394-15395	-LRB-	denotes	(
T2816	15395-15406	JJ	denotes	unpublished
T2815	15407-15411	NNS	denotes	data
T2817	15411-15412	-RRB-	denotes	)
T2818	15413-15416	CC	denotes	and
T2819	15417-15422	JJ	denotes	daily
T2820	15423-15431	NN	denotes	activity
T2821	15432-15433	-LRB-	denotes	(
T2823	15433-15438	JJ	denotes	total
T2824	15439-15445	NNS	denotes	counts
T2825	15446-15448	IN	denotes	of
T2826	15449-15457	NN	denotes	activity
T2827	15458-15461	IN	denotes	per
T2828	15462-15466	NN	denotes	hour
T2829	15466-15468	:	denotes	:
T2830	15468-15472	CD	denotes	1618
T2831	15473-15474	SYM	denotes	±
T2822	15475-15478	CD	denotes	209
T2832	15479-15482	IN	denotes	for
T2833	15483-15493	JJ	denotes	transgenic
T2834	15494-15500	CC	denotes	versus
T2835	15501-15505	CD	denotes	1987
T2837	15506-15507	SYM	denotes	±
T2836	15508-15511	CD	denotes	301
T2838	15512-15515	IN	denotes	for
T2839	15516-15520	JJ	denotes	wild
T2841	15520-15521	HYPH	denotes	-
T2840	15521-15525	NN	denotes	type
T2842	15525-15527	,	denotes	,
T2843	15527-15528	NN	denotes	p
T2845	15529-15530	SYM	denotes	>
T2844	15531-15535	CD	denotes	0.35
T2846	15535-15537	,	denotes	,
T2847	15537-15538	NN	denotes	n
T2849	15539-15540	SYM	denotes	=
T2848	15541-15542	CD	denotes	4
T2850	15542-15543	-RRB-	denotes	)
T2851	15544-15548	VBD	denotes	were
T2810	15549-15557	VBN	denotes	observed
T2852	15558-15565	IN	denotes	between
T2853	15566-15569	DT	denotes	the
T2855	15570-15580	JJ	denotes	transgenic
T2856	15581-15584	CC	denotes	and
T2857	15585-15592	NN	denotes	control
T2854	15593-15597	NNS	denotes	mice
T2858	15597-15598	.	denotes	.
T2859	15598-15706	sentence	denotes	Thus, the remarkable increase in endurance is the physiologic manifestation of muscle fiber transformation.
T2860	15599-15603	RB	denotes	Thus
T2862	15603-15605	,	denotes	,
T2863	15605-15608	DT	denotes	the
T2865	15609-15619	JJ	denotes	remarkable
T2864	15620-15628	NN	denotes	increase
T2866	15629-15631	IN	denotes	in
T2867	15632-15641	NN	denotes	endurance
T2861	15642-15644	VBZ	denotes	is
T2868	15645-15648	DT	denotes	the
T2870	15649-15660	JJ	denotes	physiologic
T2869	15661-15674	NN	denotes	manifestation
T2871	15675-15677	IN	denotes	of
T2872	15678-15684	NN	denotes	muscle
T2873	15685-15690	NN	denotes	fiber
T2874	15691-15705	NN	denotes	transformation
T2875	15705-15706	.	denotes	.
T2876	15706-15812	sentence	denotes	This suggests that genetically directed muscle fiber switch is physiologically and functionally relevant.
T2877	15707-15711	DT	denotes	This
T2878	15712-15720	VBZ	denotes	suggests
T2879	15721-15725	IN	denotes	that
T2881	15726-15737	RB	denotes	genetically
T2882	15738-15746	VBN	denotes	directed
T2884	15747-15753	NN	denotes	muscle
T2885	15754-15759	NN	denotes	fiber
T2883	15760-15766	NN	denotes	switch
T2880	15767-15769	VBZ	denotes	is
T2886	15770-15785	RB	denotes	physiologically
T2888	15786-15789	CC	denotes	and
T2889	15790-15802	RB	denotes	functionally
T2887	15803-15811	JJ	denotes	relevant
T2890	15811-15812	.	denotes	.
T2891	15812-15907	sentence	denotes	In addition, we looked at what effect the absence of PPARδ function has on exercise endurance.
T2892	15813-15815	IN	denotes	In
T2894	15816-15824	NN	denotes	addition
T2895	15824-15826	,	denotes	,
T2896	15826-15828	PRP	denotes	we
T2893	15829-15835	VBD	denotes	looked
T2897	15836-15838	IN	denotes	at
T2898	15839-15843	WDT	denotes	what
T2899	15844-15850	NN	denotes	effect
T2901	15851-15854	DT	denotes	the
T2902	15855-15862	NN	denotes	absence
T2903	15863-15865	IN	denotes	of
T2904	15866-15871	NN	denotes	PPARδ
T2905	15872-15880	NN	denotes	function
T2900	15881-15884	VBZ	denotes	has
T2906	15885-15887	IN	denotes	on
T2907	15888-15896	NN	denotes	exercise
T2908	15897-15906	NN	denotes	endurance
T2909	15906-15907	.	denotes	.
T2910	15907-16086	sentence	denotes	In the treadmill test, the PPARδ-null mice could sustain only 38% of the running time and 34% of the distance of their age- and weight-matched wild-type counterparts (Figure 6B).
T2911	15908-15910	IN	denotes	In
T2913	15911-15914	DT	denotes	the
T2915	15915-15924	NN	denotes	treadmill
T2914	15925-15929	NN	denotes	test
T2916	15929-15931	,	denotes	,
T2917	15931-15934	DT	denotes	the
T2919	15935-15940	NN	denotes	PPARδ
T2921	15940-15941	HYPH	denotes	-
T2920	15941-15945	JJ	denotes	null
T2918	15946-15950	NNS	denotes	mice
T2922	15951-15956	MD	denotes	could
T2912	15957-15964	VB	denotes	sustain
T2923	15965-15969	RB	denotes	only
T2925	15970-15972	CD	denotes	38
T2924	15972-15973	NN	denotes	%
T2926	15974-15976	IN	denotes	of
T2927	15977-15980	DT	denotes	the
T2929	15981-15988	NN	denotes	running
T2928	15989-15993	NN	denotes	time
T2930	15994-15997	CC	denotes	and
T2931	15998-16000	CD	denotes	34
T2932	16000-16001	NN	denotes	%
T2933	16002-16004	IN	denotes	of
T2934	16005-16008	DT	denotes	the
T2935	16009-16017	NN	denotes	distance
T2936	16018-16020	IN	denotes	of
T2937	16021-16026	PRP$	denotes	their
T2939	16027-16030	NN	denotes	age
T2941	16030-16031	HYPH	denotes	-
T2942	16032-16035	CC	denotes	and
T2943	16036-16042	NN	denotes	weight
T2944	16042-16043	HYPH	denotes	-
T2940	16043-16050	VBN	denotes	matched
T2945	16051-16055	JJ	denotes	wild
T2947	16055-16056	HYPH	denotes	-
T2946	16056-16060	NN	denotes	type
T2938	16061-16073	NNS	denotes	counterparts
T2948	16074-16075	-LRB-	denotes	(
T2949	16075-16081	NN	denotes	Figure
T2950	16082-16084	CD	denotes	6B
T2951	16084-16085	-RRB-	denotes	)
T2952	16085-16086	.	denotes	.
T2953	16086-16173	sentence	denotes	These results further support a role for PPARδ in enhancement of physical performance.
T2954	16087-16092	DT	denotes	These
T2955	16093-16100	NNS	denotes	results
T2957	16101-16108	RB	denotes	further
T2956	16109-16116	VBP	denotes	support
T2958	16117-16118	DT	denotes	a
T2959	16119-16123	NN	denotes	role
T2960	16124-16127	IN	denotes	for
T2961	16128-16133	NN	denotes	PPARδ
T2962	16134-16136	IN	denotes	in
T2963	16137-16148	NN	denotes	enhancement
T2964	16149-16151	IN	denotes	of
T2965	16152-16160	JJ	denotes	physical
T2966	16161-16172	NN	denotes	performance
T2967	16172-16173	.	denotes	.
T5797	16184-16189	NN	denotes	PPARδ
T5798	16190-16199	VBZ	denotes	Regulates
T5799	16200-16208	NN	denotes	Exercise
T5800	16209-16218	NN	denotes	Endurance
T5801	16218-16276	sentence	denotes	(A) Enhanced exercise performance in the transgenic mice.
T5802	16219-16220	-LRB-	denotes	(
T5803	16220-16221	LS	denotes	A
T5805	16221-16222	-RRB-	denotes	)
T5806	16223-16231	VBN	denotes	Enhanced
T5807	16232-16240	NN	denotes	exercise
T5804	16241-16252	NN	denotes	performance
T5808	16253-16255	IN	denotes	in
T5809	16256-16259	DT	denotes	the
T5811	16260-16270	JJ	denotes	transgenic
T5810	16271-16275	NNS	denotes	mice
T5812	16275-16276	.	denotes	.
T5813	16276-16437	sentence	denotes	Fourteen-week-old male transgenic and wild-type littermates with similar body weights (n = 4 for each group) were subjected to a forced treadmill exercise test.
T5814	16277-16285	CD	denotes	Fourteen
T5816	16285-16286	HYPH	denotes	-
T5815	16286-16290	NN	denotes	week
T5818	16290-16291	HYPH	denotes	-
T5817	16291-16294	JJ	denotes	old
T5820	16295-16299	JJ	denotes	male
T5821	16300-16310	JJ	denotes	transgenic
T5822	16311-16314	CC	denotes	and
T5823	16315-16319	JJ	denotes	wild
T5825	16319-16320	HYPH	denotes	-
T5824	16320-16324	NN	denotes	type
T5819	16325-16336	NNS	denotes	littermates
T5827	16337-16341	IN	denotes	with
T5828	16342-16349	JJ	denotes	similar
T5830	16350-16354	NN	denotes	body
T5829	16355-16362	NNS	denotes	weights
T5831	16363-16364	-LRB-	denotes	(
T5833	16364-16365	NN	denotes	n
T5834	16366-16367	SYM	denotes	=
T5832	16368-16369	CD	denotes	4
T5835	16370-16373	IN	denotes	for
T5836	16374-16378	DT	denotes	each
T5837	16379-16384	NN	denotes	group
T5838	16384-16385	-RRB-	denotes	)
T5839	16386-16390	VBD	denotes	were
T5826	16391-16400	VBN	denotes	subjected
T5840	16401-16403	IN	denotes	to
T5841	16404-16405	DT	denotes	a
T5843	16406-16412	VBN	denotes	forced
T5845	16413-16422	NN	denotes	treadmill
T5844	16423-16431	NN	denotes	exercise
T5842	16432-16436	NN	denotes	test
T5846	16436-16437	.	denotes	.
T5847	16437-16494	sentence	denotes	(B) Compromised exercise performance in PPARδ-null mice.
T5848	16438-16439	-LRB-	denotes	(
T5849	16439-16440	LS	denotes	B
T5851	16440-16441	-RRB-	denotes	)
T5852	16442-16453	VBN	denotes	Compromised
T5853	16454-16462	NN	denotes	exercise
T5850	16463-16474	NN	denotes	performance
T5854	16475-16477	IN	denotes	in
T5855	16478-16483	NN	denotes	PPARδ
T5857	16483-16484	HYPH	denotes	-
T5856	16484-16488	JJ	denotes	null
T5858	16489-16493	NNS	denotes	mice
T5859	16493-16494	.	denotes	.
T5860	16494-16653	sentence	denotes	Two-month-old male PPARδ-null mice and wild-type controls with similar body weights (n = 6 for each group) were subjected to a forced treadmill exercise test.
T5861	16495-16498	CD	denotes	Two
T5863	16498-16499	HYPH	denotes	-
T5862	16499-16504	NN	denotes	month
T5865	16504-16505	HYPH	denotes	-
T5864	16505-16508	JJ	denotes	old
T5867	16509-16513	JJ	denotes	male
T5868	16514-16519	NN	denotes	PPARδ
T5870	16519-16520	HYPH	denotes	-
T5869	16520-16524	JJ	denotes	null
T5866	16525-16529	NNS	denotes	mice
T5872	16530-16533	CC	denotes	and
T5873	16534-16538	JJ	denotes	wild
T5875	16538-16539	HYPH	denotes	-
T5874	16539-16543	NN	denotes	type
T5876	16544-16552	NNS	denotes	controls
T5877	16553-16557	IN	denotes	with
T5878	16558-16565	JJ	denotes	similar
T5880	16566-16570	NN	denotes	body
T5879	16571-16578	NNS	denotes	weights
T5881	16579-16580	-LRB-	denotes	(
T5883	16580-16581	NN	denotes	n
T5884	16582-16583	SYM	denotes	=
T5882	16584-16585	CD	denotes	6
T5885	16586-16589	IN	denotes	for
T5886	16590-16594	DT	denotes	each
T5887	16595-16600	NN	denotes	group
T5888	16600-16601	-RRB-	denotes	)
T5889	16602-16606	VBD	denotes	were
T5871	16607-16616	VBN	denotes	subjected
T5890	16617-16619	IN	denotes	to
T5891	16620-16621	DT	denotes	a
T5893	16622-16628	VBN	denotes	forced
T5895	16629-16638	NN	denotes	treadmill
T5894	16639-16647	NN	denotes	exercise
T5892	16648-16652	NN	denotes	test
T5896	16652-16653	.	denotes	.
T5897	16653-16696	sentence	denotes	(C) Functions of PPARδ in skeletal muscle.
T5898	16654-16655	-LRB-	denotes	(
T5899	16655-16656	LS	denotes	C
T5901	16656-16657	-RRB-	denotes	)
T5900	16658-16667	NNS	denotes	Functions
T5902	16668-16670	IN	denotes	of
T5903	16671-16676	NN	denotes	PPARδ
T5904	16677-16679	IN	denotes	in
T5905	16680-16688	JJ	denotes	skeletal
T5906	16689-16695	NN	denotes	muscle
T5907	16695-16696	.	denotes	.
T3182	16709-16712	PRP$	denotes	Our
T3183	16713-16717	NNS	denotes	data
T3184	16718-16724	VBP	denotes	reveal
T3185	16725-16729	IN	denotes	that
T3187	16730-16731	DT	denotes	a
T3189	16732-16737	NN	denotes	PPARδ
T3191	16737-16738	HYPH	denotes	-
T3190	16738-16746	VBN	denotes	mediated
T3192	16747-16762	JJ	denotes	transcriptional
T3188	16763-16770	NN	denotes	pathway
T3193	16771-16774	MD	denotes	can
T3186	16775-16783	VB	denotes	regulate
T3194	16784-16790	NN	denotes	muscle
T3195	16791-16796	NN	denotes	fiber
T3196	16797-16810	NN	denotes	specification
T3197	16810-16812	,	denotes	,
T3198	16812-16820	VBG	denotes	enabling
T3199	16821-16824	DT	denotes	the
T3200	16825-16835	NN	denotes	generation
T3201	16836-16838	IN	denotes	of
T3202	16839-16840	DT	denotes	a
T3203	16841-16847	NN	denotes	strain
T3204	16848-16850	IN	denotes	of
T3205	16851-16855	NNS	denotes	mice
T3206	16856-16860	IN	denotes	with
T3207	16861-16862	DT	denotes	a
T3209	16863-16864	``	denotes	“
T3210	16864-16868	JJ	denotes	long
T3212	16868-16869	HYPH	denotes	-
T3211	16869-16877	NN	denotes	distance
T3213	16878-16885	NN	denotes	running
T3214	16885-16886	''	denotes	”
T3208	16887-16896	NN	denotes	phenotype
T3215	16896-16897	.	denotes	.
T3216	16897-17181	sentence	denotes	We show that targeted expression of an activated form of PPARδ produces profound and coordinated increases in oxidation enzymes, mitochondrial biogenesis, and production of specialized type I fiber contractile proteins—the three hallmarks for muscle fiber type switching (Figure 6C).
T3217	16898-16900	PRP	denotes	We
T3218	16901-16905	VBP	denotes	show
T3219	16906-16910	IN	denotes	that
T3221	16911-16919	VBN	denotes	targeted
T3222	16920-16930	NN	denotes	expression
T3223	16931-16933	IN	denotes	of
T3224	16934-16936	DT	denotes	an
T3226	16937-16946	JJ	denotes	activated
T3225	16947-16951	NN	denotes	form
T3227	16952-16954	IN	denotes	of
T3228	16955-16960	NN	denotes	PPARδ
T3220	16961-16969	VBZ	denotes	produces
T3229	16970-16978	JJ	denotes	profound
T3231	16979-16982	CC	denotes	and
T3232	16983-16994	VBN	denotes	coordinated
T3230	16995-17004	NNS	denotes	increases
T3233	17005-17007	IN	denotes	in
T3234	17008-17017	NN	denotes	oxidation
T3235	17018-17025	NNS	denotes	enzymes
T3236	17025-17027	,	denotes	,
T3237	17027-17040	JJ	denotes	mitochondrial
T3238	17041-17051	NN	denotes	biogenesis
T3239	17051-17053	,	denotes	,
T3240	17053-17056	CC	denotes	and
T3241	17057-17067	NN	denotes	production
T3242	17068-17070	IN	denotes	of
T3243	17071-17082	VBN	denotes	specialized
T3245	17083-17087	NN	denotes	type
T3247	17088-17089	CD	denotes	I
T3246	17090-17095	NN	denotes	fiber
T3248	17096-17107	JJ	denotes	contractile
T3244	17108-17116	NN	denotes	proteins
T3249	17116-17117	:	denotes	—
T3250	17117-17120	DT	denotes	the
T3252	17121-17126	CD	denotes	three
T3251	17127-17136	NNS	denotes	hallmarks
T3253	17137-17140	IN	denotes	for
T3254	17141-17147	NN	denotes	muscle
T3255	17148-17153	NN	denotes	fiber
T3257	17154-17158	NN	denotes	type
T3256	17159-17168	NN	denotes	switching
T3258	17169-17170	-LRB-	denotes	(
T3259	17170-17176	NN	denotes	Figure
T3260	17177-17179	CD	denotes	6C
T3261	17179-17180	-RRB-	denotes	)
T3262	17180-17181	.	denotes	.
T3263	17181-17439	sentence	denotes	While induction of muscle oxidation enzymes by PPARδ has been seen both in vivo and in vitro (Muoio et al. 2002; Dressel et al. 2003; Luquet et al. 2003; Tanaka et al. 2003; Wang et al. 2003), its effects shown here on muscle fiber switching are unexpected.
T3264	17182-17187	IN	denotes	While
T3266	17188-17197	NN	denotes	induction
T3267	17198-17200	IN	denotes	of
T3268	17201-17207	NN	denotes	muscle
T3270	17208-17217	NN	denotes	oxidation
T3269	17218-17225	NNS	denotes	enzymes
T3271	17226-17228	IN	denotes	by
T3272	17229-17234	NN	denotes	PPARδ
T3273	17235-17238	VBZ	denotes	has
T3274	17239-17243	VBN	denotes	been
T3265	17244-17248	VBN	denotes	seen
T3276	17249-17253	CC	denotes	both
T3278	17254-17256	FW	denotes	in
T3277	17257-17261	FW	denotes	vivo
T3279	17262-17265	CC	denotes	and
T3280	17266-17268	FW	denotes	in
T3281	17269-17274	FW	denotes	vitro
T3282	17275-17276	-LRB-	denotes	(
T3283	17276-17281	NNP	denotes	Muoio
T3284	17282-17284	FW	denotes	et
T3285	17285-17288	FW	denotes	al.
T3286	17289-17293	CD	denotes	2002
T3287	17293-17294	:	denotes	;
T3288	17295-17302	NNP	denotes	Dressel
T3289	17303-17305	FW	denotes	et
T3290	17306-17309	FW	denotes	al.
T3291	17310-17314	CD	denotes	2003
T3292	17314-17315	:	denotes	;
T3293	17316-17322	NNP	denotes	Luquet
T3294	17323-17325	FW	denotes	et
T3295	17326-17329	FW	denotes	al.
T3296	17330-17334	CD	denotes	2003
T3297	17334-17335	:	denotes	;
T3298	17336-17342	NNP	denotes	Tanaka
T3299	17343-17345	FW	denotes	et
T3300	17346-17349	FW	denotes	al.
T3301	17350-17354	CD	denotes	2003
T3302	17354-17355	:	denotes	;
T3303	17356-17360	NNP	denotes	Wang
T3304	17361-17363	FW	denotes	et
T3305	17364-17367	FW	denotes	al.
T3306	17368-17372	CD	denotes	2003
T3307	17372-17373	-RRB-	denotes	)
T3308	17373-17375	,	denotes	,
T3309	17375-17378	PRP$	denotes	its
T3310	17379-17386	NNS	denotes	effects
T3311	17387-17392	VBN	denotes	shown
T3312	17393-17397	RB	denotes	here
T3313	17398-17400	IN	denotes	on
T3314	17401-17407	NN	denotes	muscle
T3315	17408-17413	NN	denotes	fiber
T3316	17414-17423	NN	denotes	switching
T3275	17424-17427	VBP	denotes	are
T3317	17428-17438	JJ	denotes	unexpected
T3318	17438-17439	.	denotes	.
T3319	17439-17628	sentence	denotes	These progressive changes in oxidative capacity in conjunction with eventual changes in type I muscle fiber lead to a dramatically improved exercise profile and protection against obesity.
T3320	17440-17445	DT	denotes	These
T3322	17446-17457	JJ	denotes	progressive
T3321	17458-17465	NNS	denotes	changes
T3324	17466-17468	IN	denotes	in
T3325	17469-17478	JJ	denotes	oxidative
T3326	17479-17487	NN	denotes	capacity
T3327	17488-17490	IN	denotes	in
T3328	17491-17502	NN	denotes	conjunction
T3329	17503-17507	IN	denotes	with
T3330	17508-17516	JJ	denotes	eventual
T3331	17517-17524	NNS	denotes	changes
T3332	17525-17527	IN	denotes	in
T3333	17528-17532	NN	denotes	type
T3335	17533-17534	CD	denotes	I
T3336	17535-17541	NN	denotes	muscle
T3334	17542-17547	NN	denotes	fiber
T3323	17548-17552	VBP	denotes	lead
T3337	17553-17555	IN	denotes	to
T3338	17556-17557	DT	denotes	a
T3340	17558-17570	RB	denotes	dramatically
T3341	17571-17579	VBN	denotes	improved
T3342	17580-17588	NN	denotes	exercise
T3339	17589-17596	NN	denotes	profile
T3343	17597-17600	CC	denotes	and
T3344	17601-17611	NN	denotes	protection
T3345	17612-17619	IN	denotes	against
T3346	17620-17627	NN	denotes	obesity
T3347	17627-17628	.	denotes	.
T3348	17628-17883	sentence	denotes	This does not solely depend on achieving a directed muscle fiber type switch but also requires all the associated changes in neural innervation, motor neuron function, and peripheral metabolic adaptation to enable a new integrated physiological response.
T3349	17629-17633	DT	denotes	This
T3351	17634-17638	VBZ	denotes	does
T3352	17639-17642	RB	denotes	not
T3353	17643-17649	RB	denotes	solely
T3350	17650-17656	VB	denotes	depend
T3354	17657-17659	IN	denotes	on
T3355	17660-17669	VBG	denotes	achieving
T3356	17670-17671	DT	denotes	a
T3358	17672-17680	VBN	denotes	directed
T3359	17681-17687	NN	denotes	muscle
T3360	17688-17693	NN	denotes	fiber
T3361	17694-17698	NN	denotes	type
T3357	17699-17705	NN	denotes	switch
T3362	17706-17709	CC	denotes	but
T3363	17710-17714	RB	denotes	also
T3364	17715-17723	VBZ	denotes	requires
T3365	17724-17727	PDT	denotes	all
T3367	17728-17731	DT	denotes	the
T3368	17732-17742	VBN	denotes	associated
T3366	17743-17750	NNS	denotes	changes
T3369	17751-17753	IN	denotes	in
T3370	17754-17760	JJ	denotes	neural
T3371	17761-17772	NN	denotes	innervation
T3372	17772-17774	,	denotes	,
T3373	17774-17779	NN	denotes	motor
T3374	17780-17786	NN	denotes	neuron
T3375	17787-17795	NN	denotes	function
T3376	17795-17797	,	denotes	,
T3377	17797-17800	CC	denotes	and
T3378	17801-17811	JJ	denotes	peripheral
T3380	17812-17821	JJ	denotes	metabolic
T3379	17822-17832	NN	denotes	adaptation
T3381	17833-17835	TO	denotes	to
T3382	17836-17842	VB	denotes	enable
T3383	17843-17844	DT	denotes	a
T3385	17845-17848	JJ	denotes	new
T3386	17849-17859	VBN	denotes	integrated
T3387	17860-17873	JJ	denotes	physiological
T3384	17874-17882	NN	denotes	response
T3388	17882-17883	.	denotes	.
T3389	17883-18022	sentence	denotes	Accordingly, activation of muscle PPARδ essentially recapitulates the effects of exercise training even in the absence of training itself.
T3390	17884-17895	RB	denotes	Accordingly
T3392	17895-17897	,	denotes	,
T3393	17897-17907	NN	denotes	activation
T3394	17908-17910	IN	denotes	of
T3395	17911-17917	NN	denotes	muscle
T3396	17918-17923	NN	denotes	PPARδ
T3397	17924-17935	RB	denotes	essentially
T3391	17936-17949	VBZ	denotes	recapitulates
T3398	17950-17953	DT	denotes	the
T3399	17954-17961	NNS	denotes	effects
T3400	17962-17964	IN	denotes	of
T3401	17965-17973	NN	denotes	exercise
T3402	17974-17982	NN	denotes	training
T3403	17983-17987	RB	denotes	even
T3404	17988-17990	IN	denotes	in
T3405	17991-17994	DT	denotes	the
T3406	17995-18002	NN	denotes	absence
T3407	18003-18005	IN	denotes	of
T3408	18006-18014	VBG	denotes	training
T3409	18015-18021	PRP	denotes	itself
T3410	18021-18022	.	denotes	.
T3411	18022-18115	sentence	denotes	To our knowledge, this has not been directly described for any other transcriptional factor.
T3412	18023-18025	IN	denotes	To
T3414	18026-18029	PRP$	denotes	our
T3415	18030-18039	NN	denotes	knowledge
T3416	18039-18041	,	denotes	,
T3417	18041-18045	DT	denotes	this
T3418	18046-18049	VBZ	denotes	has
T3419	18050-18053	RB	denotes	not
T3420	18054-18058	VBN	denotes	been
T3421	18059-18067	RB	denotes	directly
T3413	18068-18077	VBN	denotes	described
T3422	18078-18081	IN	denotes	for
T3423	18082-18085	DT	denotes	any
T3425	18086-18091	JJ	denotes	other
T3426	18092-18107	JJ	denotes	transcriptional
T3424	18108-18114	NN	denotes	factor
T3427	18114-18115	.	denotes	.
T3428	18115-18433	sentence	denotes	The muscle phenotypes described here are remarkably similar to those of transgenic mice expressing either calcineurin, calmodulin-dependent kinase, or PGC-1α (Naya et al. 2000; Lin et al. 2002; Wu et al. 2002), indicating that PPARδ could be one of the hypothetical downstream transcription factors of these pathways.
T3429	18116-18119	DT	denotes	The
T3431	18120-18126	NN	denotes	muscle
T3430	18127-18137	NNS	denotes	phenotypes
T3433	18138-18147	VBN	denotes	described
T3434	18148-18152	RB	denotes	here
T3432	18153-18156	VBP	denotes	are
T3435	18157-18167	RB	denotes	remarkably
T3436	18168-18175	JJ	denotes	similar
T3437	18176-18178	IN	denotes	to
T3438	18179-18184	DT	denotes	those
T3439	18185-18187	IN	denotes	of
T3440	18188-18198	JJ	denotes	transgenic
T3441	18199-18203	NNS	denotes	mice
T3442	18204-18214	VBG	denotes	expressing
T3443	18215-18221	CC	denotes	either
T3444	18222-18233	NN	denotes	calcineurin
T3445	18233-18235	,	denotes	,
T3446	18235-18245	NN	denotes	calmodulin
T3448	18245-18246	HYPH	denotes	-
T3447	18246-18255	JJ	denotes	dependent
T3449	18256-18262	NN	denotes	kinase
T3450	18262-18264	,	denotes	,
T3451	18264-18266	CC	denotes	or
T3452	18267-18270	NN	denotes	PGC
T3453	18270-18271	HYPH	denotes	-
T3454	18271-18273	CD	denotes	1α
T3455	18274-18275	-LRB-	denotes	(
T3456	18275-18279	NNP	denotes	Naya
T3457	18280-18282	FW	denotes	et
T3458	18283-18286	FW	denotes	al.
T3459	18287-18291	CD	denotes	2000
T3460	18291-18292	:	denotes	;
T3461	18293-18296	NNP	denotes	Lin
T3462	18297-18299	FW	denotes	et
T3463	18300-18303	FW	denotes	al.
T3464	18304-18308	CD	denotes	2002
T3465	18308-18309	:	denotes	;
T3466	18310-18312	NNP	denotes	Wu
T3467	18313-18315	FW	denotes	et
T3468	18316-18319	FW	denotes	al.
T3469	18320-18324	CD	denotes	2002
T3470	18324-18325	-RRB-	denotes	)
T3471	18325-18327	,	denotes	,
T3472	18327-18337	VBG	denotes	indicating
T3473	18338-18342	IN	denotes	that
T3475	18343-18348	NN	denotes	PPARδ
T3476	18349-18354	MD	denotes	could
T3474	18355-18357	VB	denotes	be
T3477	18358-18361	CD	denotes	one
T3478	18362-18364	IN	denotes	of
T3479	18365-18368	DT	denotes	the
T3481	18369-18381	JJ	denotes	hypothetical
T3482	18382-18392	JJ	denotes	downstream
T3483	18393-18406	NN	denotes	transcription
T3480	18407-18414	NNS	denotes	factors
T3484	18415-18417	IN	denotes	of
T3485	18418-18423	DT	denotes	these
T3486	18424-18432	NNS	denotes	pathways
T3487	18432-18433	.	denotes	.
T3488	18433-18592	sentence	denotes	It is important to note that, from our ligand and gain-of-function transgenic studies, PPARδ needs to be activated in order to direct the muscle fiber switch.
T3489	18434-18436	PRP	denotes	It
T3490	18437-18439	VBZ	denotes	is
T3491	18440-18449	JJ	denotes	important
T3492	18450-18452	TO	denotes	to
T3493	18453-18457	VB	denotes	note
T3494	18458-18462	IN	denotes	that
T3496	18462-18464	,	denotes	,
T3497	18464-18468	IN	denotes	from
T3498	18469-18472	PRP$	denotes	our
T3500	18473-18479	NN	denotes	ligand
T3501	18480-18483	CC	denotes	and
T3502	18484-18488	NN	denotes	gain
T3503	18488-18489	HYPH	denotes	-
T3504	18489-18491	IN	denotes	of
T3505	18491-18492	HYPH	denotes	-
T3506	18492-18500	NN	denotes	function
T3507	18501-18511	JJ	denotes	transgenic
T3499	18512-18519	NNS	denotes	studies
T3508	18519-18521	,	denotes	,
T3509	18521-18526	NN	denotes	PPARδ
T3495	18527-18532	VBZ	denotes	needs
T3510	18533-18535	TO	denotes	to
T3512	18536-18538	VB	denotes	be
T3511	18539-18548	VBN	denotes	activated
T3513	18549-18551	IN	denotes	in
T3514	18552-18557	NN	denotes	order
T3515	18558-18560	TO	denotes	to
T3516	18561-18567	VB	denotes	direct
T3517	18568-18571	DT	denotes	the
T3519	18572-18578	NN	denotes	muscle
T3520	18579-18584	NN	denotes	fiber
T3518	18585-18591	NN	denotes	switch
T3521	18591-18592	.	denotes	.
T3522	18592-18826	sentence	denotes	Indeed, in a recent report by Luquet et al. (2003), simple overexpression of wild-type PPARδ in muscle was found not to be sufficient to promote a fiber switch or obesity resistance, although certain oxidation enzymes were increased.
T3523	18593-18599	RB	denotes	Indeed
T3525	18599-18601	,	denotes	,
T3526	18601-18603	IN	denotes	in
T3527	18604-18605	DT	denotes	a
T3529	18606-18612	JJ	denotes	recent
T3528	18613-18619	NN	denotes	report
T3530	18620-18622	IN	denotes	by
T3531	18623-18629	NNP	denotes	Luquet
T3532	18630-18632	FW	denotes	et
T3533	18633-18636	FW	denotes	al.
T3534	18637-18638	-LRB-	denotes	(
T3535	18638-18642	CD	denotes	2003
T3536	18642-18643	-RRB-	denotes	)
T3537	18643-18645	,	denotes	,
T3538	18645-18651	JJ	denotes	simple
T3539	18652-18666	NN	denotes	overexpression
T3540	18667-18669	IN	denotes	of
T3541	18670-18674	JJ	denotes	wild
T3543	18674-18675	HYPH	denotes	-
T3542	18675-18679	NN	denotes	type
T3544	18680-18685	NN	denotes	PPARδ
T3545	18686-18688	IN	denotes	in
T3546	18689-18695	NN	denotes	muscle
T3547	18696-18699	VBD	denotes	was
T3524	18700-18705	VBN	denotes	found
T3548	18706-18709	RB	denotes	not
T3550	18710-18712	TO	denotes	to
T3549	18713-18715	VB	denotes	be
T3551	18716-18726	JJ	denotes	sufficient
T3552	18727-18729	TO	denotes	to
T3553	18730-18737	VB	denotes	promote
T3554	18738-18739	DT	denotes	a
T3556	18740-18745	NN	denotes	fiber
T3555	18746-18752	NN	denotes	switch
T3557	18753-18755	CC	denotes	or
T3558	18756-18763	NN	denotes	obesity
T3559	18764-18774	NN	denotes	resistance
T3560	18774-18776	,	denotes	,
T3561	18776-18784	IN	denotes	although
T3563	18785-18792	JJ	denotes	certain
T3565	18793-18802	NN	denotes	oxidation
T3564	18803-18810	NNS	denotes	enzymes
T3566	18811-18815	VBD	denotes	were
T3562	18816-18825	VBN	denotes	increased
T3567	18825-18826	.	denotes	.
T3568	18826-18936	sentence	denotes	This supports the model in Figure 6C that the activating signal or ligand, but not the receptor, is limiting.
T3569	18827-18831	DT	denotes	This
T3570	18832-18840	VBZ	denotes	supports
T3571	18841-18844	DT	denotes	the
T3572	18845-18850	NN	denotes	model
T3573	18851-18853	IN	denotes	in
T3574	18854-18860	NN	denotes	Figure
T3575	18861-18863	CD	denotes	6C
T3576	18864-18868	IN	denotes	that
T3578	18869-18872	DT	denotes	the
T3580	18873-18883	VBG	denotes	activating
T3579	18884-18890	NN	denotes	signal
T3581	18891-18893	CC	denotes	or
T3582	18894-18900	NN	denotes	ligand
T3583	18900-18902	,	denotes	,
T3584	18902-18905	CC	denotes	but
T3585	18906-18909	RB	denotes	not
T3586	18910-18913	DT	denotes	the
T3587	18914-18922	NN	denotes	receptor
T3588	18922-18924	,	denotes	,
T3577	18924-18926	VBZ	denotes	is
T3589	18927-18935	VBG	denotes	limiting
T3590	18935-18936	.	denotes	.
T3591	18936-19098	sentence	denotes	Thus, PPARδ activation, rather than merely an increase of PPARδ levels, is an essential element for fiber switching and its associated functional manifestations.
T3592	18937-18941	RB	denotes	Thus
T3594	18941-18943	,	denotes	,
T3595	18943-18948	NN	denotes	PPARδ
T3596	18949-18959	NN	denotes	activation
T3597	18959-18961	,	denotes	,
T3598	18961-18967	RB	denotes	rather
T3599	18968-18972	IN	denotes	than
T3600	18973-18979	RB	denotes	merely
T3602	18980-18982	DT	denotes	an
T3601	18983-18991	NN	denotes	increase
T3603	18992-18994	IN	denotes	of
T3604	18995-19000	NN	denotes	PPARδ
T3605	19001-19007	NNS	denotes	levels
T3606	19007-19009	,	denotes	,
T3593	19009-19011	VBZ	denotes	is
T3607	19012-19014	DT	denotes	an
T3609	19015-19024	JJ	denotes	essential
T3608	19025-19032	NN	denotes	element
T3610	19033-19036	IN	denotes	for
T3611	19037-19042	NN	denotes	fiber
T3612	19043-19052	NN	denotes	switching
T3613	19053-19056	CC	denotes	and
T3614	19057-19060	PRP$	denotes	its
T3616	19061-19071	VBN	denotes	associated
T3617	19072-19082	JJ	denotes	functional
T3615	19083-19097	NNS	denotes	manifestations
T3618	19097-19098	.	denotes	.
T3619	19098-19174	sentence	denotes	How might endogenous PPARδ become activated naturally by exercise training?
T3620	19099-19102	WRB	denotes	How
T3622	19103-19108	MD	denotes	might
T3623	19109-19119	JJ	denotes	endogenous
T3624	19120-19125	NN	denotes	PPARδ
T3621	19126-19132	VB	denotes	become
T3625	19133-19142	VBN	denotes	activated
T3626	19143-19152	RB	denotes	naturally
T3627	19153-19155	IN	denotes	by
T3628	19156-19164	NN	denotes	exercise
T3629	19165-19173	NN	denotes	training
T3630	19173-19174	.	denotes	?
T3631	19174-19353	sentence	denotes	First, it is possible that exercise generates or increases endogenous ligands for PPARδ as tissues are undergoing substantial increases in fatty-acid internalization and burning.
T3632	19175-19180	RB	denotes	First
T3634	19180-19182	,	denotes	,
T3635	19182-19184	PRP	denotes	it
T3633	19185-19187	VBZ	denotes	is
T3636	19188-19196	JJ	denotes	possible
T3637	19197-19201	IN	denotes	that
T3639	19202-19210	NN	denotes	exercise
T3638	19211-19220	VBZ	denotes	generates
T3640	19221-19223	CC	denotes	or
T3641	19224-19233	VBZ	denotes	increases
T3642	19234-19244	JJ	denotes	endogenous
T3643	19245-19252	NNS	denotes	ligands
T3644	19253-19256	IN	denotes	for
T3645	19257-19262	NN	denotes	PPARδ
T3646	19263-19265	IN	denotes	as
T3648	19266-19273	NNS	denotes	tissues
T3649	19274-19277	VBP	denotes	are
T3647	19278-19288	VBG	denotes	undergoing
T3650	19289-19300	JJ	denotes	substantial
T3651	19301-19310	NNS	denotes	increases
T3652	19311-19313	IN	denotes	in
T3653	19314-19319	JJ	denotes	fatty
T3655	19319-19320	HYPH	denotes	-
T3654	19320-19324	NN	denotes	acid
T3656	19325-19340	NN	denotes	internalization
T3657	19341-19344	CC	denotes	and
T3658	19345-19352	NN	denotes	burning
T3659	19352-19353	.	denotes	.
T3660	19353-19407	sentence	denotes	Fatty acids and their metabolites can activate PPARδ.
T3661	19354-19359	JJ	denotes	Fatty
T3662	19360-19365	NNS	denotes	acids
T3664	19366-19369	CC	denotes	and
T3665	19370-19375	PRP$	denotes	their
T3666	19376-19387	NNS	denotes	metabolites
T3667	19388-19391	MD	denotes	can
T3663	19392-19400	VB	denotes	activate
T3668	19401-19406	NN	denotes	PPARδ
T3669	19406-19407	.	denotes	.
T3670	19407-19518	sentence	denotes	A second model is that exercise may induce expression of PGC-1α (Goto et al. 2000) and thereby activate PPARδ.
T3671	19408-19409	DT	denotes	A
T3673	19410-19416	JJ	denotes	second
T3672	19417-19422	NN	denotes	model
T3674	19423-19425	VBZ	denotes	is
T3675	19426-19430	IN	denotes	that
T3677	19431-19439	NN	denotes	exercise
T3678	19440-19443	MD	denotes	may
T3676	19444-19450	VB	denotes	induce
T3679	19451-19461	NN	denotes	expression
T3680	19462-19464	IN	denotes	of
T3681	19465-19468	NN	denotes	PGC
T3682	19468-19469	HYPH	denotes	-
T3683	19469-19471	CD	denotes	1α
T3684	19472-19473	-LRB-	denotes	(
T3685	19473-19477	NNP	denotes	Goto
T3686	19478-19480	FW	denotes	et
T3687	19481-19484	FW	denotes	al.
T3688	19485-19489	CD	denotes	2000
T3689	19489-19490	-RRB-	denotes	)
T3690	19491-19494	CC	denotes	and
T3691	19495-19502	RB	denotes	thereby
T3692	19503-19511	VBP	denotes	activate
T3693	19512-19517	NN	denotes	PPARδ
T3694	19517-19518	.	denotes	.
T3695	19518-19723	sentence	denotes	This is consistent with previous work in which we have shown that PGC-1α physically associates with PPARδ in muscle tissue and can powerfully activate it even in the absence of ligands (Wang et al. 2003).
T3696	19519-19523	DT	denotes	This
T3697	19524-19526	VBZ	denotes	is
T3698	19527-19537	JJ	denotes	consistent
T3699	19538-19542	IN	denotes	with
T3700	19543-19551	JJ	denotes	previous
T3701	19552-19556	NN	denotes	work
T3702	19557-19559	IN	denotes	in
T3704	19560-19565	WDT	denotes	which
T3705	19566-19568	PRP	denotes	we
T3706	19569-19573	VBP	denotes	have
T3703	19574-19579	VBN	denotes	shown
T3707	19580-19584	IN	denotes	that
T3709	19585-19588	NN	denotes	PGC
T3710	19588-19589	HYPH	denotes	-
T3711	19589-19591	CD	denotes	1α
T3712	19592-19602	RB	denotes	physically
T3708	19603-19613	VBZ	denotes	associates
T3713	19614-19618	IN	denotes	with
T3714	19619-19624	NN	denotes	PPARδ
T3715	19625-19627	IN	denotes	in
T3716	19628-19634	NN	denotes	muscle
T3717	19635-19641	NN	denotes	tissue
T3718	19642-19645	CC	denotes	and
T3719	19646-19649	MD	denotes	can
T3721	19650-19660	RB	denotes	powerfully
T3720	19661-19669	VB	denotes	activate
T3722	19670-19672	PRP	denotes	it
T3723	19673-19677	RB	denotes	even
T3724	19678-19680	IN	denotes	in
T3725	19681-19684	DT	denotes	the
T3726	19685-19692	NN	denotes	absence
T3727	19693-19695	IN	denotes	of
T3728	19696-19703	NNS	denotes	ligands
T3729	19704-19705	-LRB-	denotes	(
T3730	19705-19709	NNP	denotes	Wang
T3731	19710-19712	FW	denotes	et
T3732	19713-19716	FW	denotes	al.
T3733	19717-19721	CD	denotes	2003
T3734	19721-19722	-RRB-	denotes	)
T3735	19722-19723	.	denotes	.
T3736	19723-19828	sentence	denotes	Alternatively, PPARδ may be activated by a distal upstream signaling component such as a kinase cascade.
T3737	19724-19737	RB	denotes	Alternatively
T3739	19737-19739	,	denotes	,
T3740	19739-19744	NN	denotes	PPARδ
T3741	19745-19748	MD	denotes	may
T3742	19749-19751	VB	denotes	be
T3738	19752-19761	VBN	denotes	activated
T3743	19762-19764	IN	denotes	by
T3744	19765-19766	DT	denotes	a
T3746	19767-19773	JJ	denotes	distal
T3747	19774-19782	JJ	denotes	upstream
T3748	19783-19792	NN	denotes	signaling
T3745	19793-19802	NN	denotes	component
T3749	19803-19807	JJ	denotes	such
T3750	19808-19810	IN	denotes	as
T3751	19811-19812	DT	denotes	a
T3753	19813-19819	NN	denotes	kinase
T3752	19820-19827	NN	denotes	cascade
T3754	19827-19828	.	denotes	.
T3755	19828-20028	sentence	denotes	Further dissecting the interactions between PPARδ and its regulatory components will be necessary to fully understand the molecular basis of muscle fiber determination pertinent to exercise training.
T3756	19829-19836	RB	denotes	Further
T3757	19837-19847	VBG	denotes	dissecting
T3759	19848-19851	DT	denotes	the
T3760	19852-19864	NNS	denotes	interactions
T3761	19865-19872	IN	denotes	between
T3762	19873-19878	NN	denotes	PPARδ
T3763	19879-19882	CC	denotes	and
T3764	19883-19886	PRP$	denotes	its
T3766	19887-19897	JJ	denotes	regulatory
T3765	19898-19908	NNS	denotes	components
T3767	19909-19913	MD	denotes	will
T3758	19914-19916	VB	denotes	be
T3768	19917-19926	JJ	denotes	necessary
T3769	19927-19929	TO	denotes	to
T3771	19930-19935	RB	denotes	fully
T3770	19936-19946	VB	denotes	understand
T3772	19947-19950	DT	denotes	the
T3774	19951-19960	JJ	denotes	molecular
T3773	19961-19966	NN	denotes	basis
T3775	19967-19969	IN	denotes	of
T3776	19970-19976	NN	denotes	muscle
T3777	19977-19982	NN	denotes	fiber
T3778	19983-19996	NN	denotes	determination
T3779	19997-20006	JJ	denotes	pertinent
T3780	20007-20009	IN	denotes	to
T3781	20010-20018	NN	denotes	exercise
T3782	20019-20027	NN	denotes	training
T3783	20027-20028	.	denotes	.
T3784	20028-20118	sentence	denotes	Skeletal muscle is a major site to regulate whole-body fatty-acid and glucose metabolism.
T3785	20029-20037	JJ	denotes	Skeletal
T3786	20038-20044	NN	denotes	muscle
T3787	20045-20047	VBZ	denotes	is
T3788	20048-20049	DT	denotes	a
T3790	20050-20055	JJ	denotes	major
T3789	20056-20060	NN	denotes	site
T3791	20061-20063	TO	denotes	to
T3792	20064-20072	VB	denotes	regulate
T3793	20073-20078	JJ	denotes	whole
T3795	20078-20079	HYPH	denotes	-
T3794	20079-20083	NN	denotes	body
T3797	20084-20089	JJ	denotes	fatty
T3799	20089-20090	HYPH	denotes	-
T3798	20090-20094	NN	denotes	acid
T3800	20095-20098	CC	denotes	and
T3801	20099-20106	NN	denotes	glucose
T3796	20107-20117	NN	denotes	metabolism
T3802	20117-20118	.	denotes	.
T3803	20118-20235	sentence	denotes	We show that mice with increased oxidative fibers are resistant to high-fat-induced obesity and glucose intolerance.
T3804	20119-20121	PRP	denotes	We
T3805	20122-20126	VBP	denotes	show
T3806	20127-20131	IN	denotes	that
T3808	20132-20136	NNS	denotes	mice
T3809	20137-20141	IN	denotes	with
T3810	20142-20151	VBN	denotes	increased
T3812	20152-20161	JJ	denotes	oxidative
T3811	20162-20168	NNS	denotes	fibers
T3807	20169-20172	VBP	denotes	are
T3813	20173-20182	JJ	denotes	resistant
T3814	20183-20185	IN	denotes	to
T3815	20186-20190	JJ	denotes	high
T3817	20190-20191	HYPH	denotes	-
T3816	20191-20194	NN	denotes	fat
T3819	20194-20195	HYPH	denotes	-
T3818	20195-20202	VBN	denotes	induced
T3820	20203-20210	NN	denotes	obesity
T3821	20211-20214	CC	denotes	and
T3822	20215-20222	NN	denotes	glucose
T3823	20223-20234	NN	denotes	intolerance
T3824	20234-20235	.	denotes	.
T3825	20235-20353	sentence	denotes	Moreover, ligand studies provide compelling evidence that activation of endogenous PPARδ can produce similar effects.
T3826	20236-20244	RB	denotes	Moreover
T3828	20244-20246	,	denotes	,
T3829	20246-20252	NN	denotes	ligand
T3830	20253-20260	NNS	denotes	studies
T3827	20261-20268	VBP	denotes	provide
T3831	20269-20279	JJ	denotes	compelling
T3832	20280-20288	NN	denotes	evidence
T3833	20289-20293	IN	denotes	that
T3835	20294-20304	NN	denotes	activation
T3836	20305-20307	IN	denotes	of
T3837	20308-20318	JJ	denotes	endogenous
T3838	20319-20324	NN	denotes	PPARδ
T3839	20325-20328	MD	denotes	can
T3834	20329-20336	VB	denotes	produce
T3840	20337-20344	JJ	denotes	similar
T3841	20345-20352	NNS	denotes	effects
T3842	20352-20353	.	denotes	.
T3843	20353-20438	sentence	denotes	Might PPARδ have any beneficial effects on glucose metabolism in the lean condition?
T3844	20354-20359	MD	denotes	Might
T3846	20360-20365	NN	denotes	PPARδ
T3845	20366-20370	VB	denotes	have
T3847	20371-20374	DT	denotes	any
T3849	20375-20385	JJ	denotes	beneficial
T3848	20386-20393	NNS	denotes	effects
T3850	20394-20396	IN	denotes	on
T3851	20397-20404	NN	denotes	glucose
T3852	20405-20415	NN	denotes	metabolism
T3853	20416-20418	IN	denotes	in
T3854	20419-20422	DT	denotes	the
T3856	20423-20427	JJ	denotes	lean
T3855	20428-20437	NN	denotes	condition
T3857	20437-20438	.	denotes	?
T3858	20438-20639	sentence	denotes	This has not been explored; however, insulin resistance in the elderly is confined mostly to skeletal muscle and may be due to reduction of mitochondrial number and/or function (Petersen et al. 2003).
T3859	20439-20443	DT	denotes	This
T3861	20444-20447	VBZ	denotes	has
T3862	20448-20451	RB	denotes	not
T3863	20452-20456	VBN	denotes	been
T3860	20457-20465	VBN	denotes	explored
T3865	20465-20466	:	denotes	;
T3866	20467-20474	RB	denotes	however
T3867	20474-20476	,	denotes	,
T3868	20476-20483	NN	denotes	insulin
T3869	20484-20494	NN	denotes	resistance
T3870	20495-20497	IN	denotes	in
T3871	20498-20501	DT	denotes	the
T3872	20502-20509	JJ	denotes	elderly
T3873	20510-20512	VBZ	denotes	is
T3864	20513-20521	VBN	denotes	confined
T3874	20522-20528	RB	denotes	mostly
T3875	20529-20531	IN	denotes	to
T3876	20532-20540	JJ	denotes	skeletal
T3877	20541-20547	NN	denotes	muscle
T3878	20548-20551	CC	denotes	and
T3879	20552-20555	MD	denotes	may
T3880	20556-20558	VB	denotes	be
T3881	20559-20562	IN	denotes	due
T3882	20563-20565	IN	denotes	to
T3883	20566-20575	NN	denotes	reduction
T3884	20576-20578	IN	denotes	of
T3885	20579-20592	JJ	denotes	mitochondrial
T3886	20593-20599	NN	denotes	number
T3887	20600-20603	CC	denotes	and
T3888	20603-20604	HYPH	denotes	/
T3889	20604-20606	CC	denotes	or
T3890	20607-20615	NN	denotes	function
T3891	20616-20617	-LRB-	denotes	(
T3892	20617-20625	NNP	denotes	Petersen
T3893	20626-20628	FW	denotes	et
T3894	20629-20632	FW	denotes	al.
T3895	20633-20637	CD	denotes	2003
T3896	20637-20638	-RRB-	denotes	)
T3897	20638-20639	.	denotes	.
T3898	20639-20815	sentence	denotes	The ability of PPARδ to stimulate mitochondrial biogenesis and oxidative function suggests that PPARδ could be important for control of insulin resistance during normal aging.
T3899	20640-20643	DT	denotes	The
T3900	20644-20651	NN	denotes	ability
T3902	20652-20654	IN	denotes	of
T3903	20655-20660	NN	denotes	PPARδ
T3904	20661-20663	TO	denotes	to
T3905	20664-20673	VB	denotes	stimulate
T3906	20674-20687	JJ	denotes	mitochondrial
T3907	20688-20698	NN	denotes	biogenesis
T3908	20699-20702	CC	denotes	and
T3909	20703-20712	JJ	denotes	oxidative
T3910	20713-20721	NN	denotes	function
T3901	20722-20730	VBZ	denotes	suggests
T3911	20731-20735	IN	denotes	that
T3913	20736-20741	NN	denotes	PPARδ
T3914	20742-20747	MD	denotes	could
T3912	20748-20750	VB	denotes	be
T3915	20751-20760	JJ	denotes	important
T3916	20761-20764	IN	denotes	for
T3917	20765-20772	NN	denotes	control
T3918	20773-20775	IN	denotes	of
T3919	20776-20783	NN	denotes	insulin
T3920	20784-20794	NN	denotes	resistance
T3921	20795-20801	IN	denotes	during
T3922	20802-20808	JJ	denotes	normal
T3923	20809-20814	NN	denotes	aging
T3924	20814-20815	.	denotes	.
T3925	20815-21029	sentence	denotes	Together, these data indicate that PPARδ and its ligands comprise a key molecular switch to regulate muscle fiber specification, obesity resistance, insulin sensitivity, and, most surprisingly, physical endurance.
T3926	20816-20824	RB	denotes	Together
T3928	20824-20826	,	denotes	,
T3929	20826-20831	DT	denotes	these
T3930	20832-20836	NNS	denotes	data
T3927	20837-20845	VBP	denotes	indicate
T3931	20846-20850	IN	denotes	that
T3933	20851-20856	NN	denotes	PPARδ
T3934	20857-20860	CC	denotes	and
T3935	20861-20864	PRP$	denotes	its
T3936	20865-20872	NNS	denotes	ligands
T3932	20873-20881	VBP	denotes	comprise
T3937	20882-20883	DT	denotes	a
T3939	20884-20887	JJ	denotes	key
T3940	20888-20897	JJ	denotes	molecular
T3938	20898-20904	NN	denotes	switch
T3941	20905-20907	TO	denotes	to
T3942	20908-20916	VB	denotes	regulate
T3943	20917-20923	NN	denotes	muscle
T3944	20924-20929	NN	denotes	fiber
T3945	20930-20943	NN	denotes	specification
T3946	20943-20945	,	denotes	,
T3947	20945-20952	NN	denotes	obesity
T3948	20953-20963	NN	denotes	resistance
T3949	20963-20965	,	denotes	,
T3950	20965-20972	NN	denotes	insulin
T3951	20973-20984	NN	denotes	sensitivity
T3952	20984-20986	,	denotes	,
T3953	20986-20989	CC	denotes	and
T3954	20989-20991	,	denotes	,
T3955	20991-20995	RBS	denotes	most
T3956	20996-21008	RB	denotes	surprisingly
T3958	21008-21010	,	denotes	,
T3959	21010-21018	JJ	denotes	physical
T3957	21019-21028	NN	denotes	endurance
T3960	21028-21029	.	denotes	.
T3961	21029-21169	sentence	denotes	This work demonstrates that complex physiologic properties such as fatigue, endurance, and running capacity can be genetically manipulated.
T3962	21030-21034	DT	denotes	This
T3963	21035-21039	NN	denotes	work
T3964	21040-21052	VBZ	denotes	demonstrates
T3965	21053-21057	IN	denotes	that
T3967	21058-21065	JJ	denotes	complex
T3969	21066-21077	JJ	denotes	physiologic
T3968	21078-21088	NNS	denotes	properties
T3970	21089-21093	JJ	denotes	such
T3971	21094-21096	IN	denotes	as
T3972	21097-21104	NN	denotes	fatigue
T3973	21104-21106	,	denotes	,
T3974	21106-21115	NN	denotes	endurance
T3975	21115-21117	,	denotes	,
T3976	21117-21120	CC	denotes	and
T3977	21121-21128	NN	denotes	running
T3978	21129-21137	NN	denotes	capacity
T3979	21138-21141	MD	denotes	can
T3980	21142-21144	VB	denotes	be
T3981	21145-21156	RB	denotes	genetically
T3966	21157-21168	VBN	denotes	manipulated
T3982	21168-21169	.	denotes	.
T4058	21194-21201	NNS	denotes	Animals
T4059	21201-21202	.	denotes	.
T4060	21202-21352	sentence	denotes	The transactivation domain (78 amino acid residues, corresponding to residues 413–490) of VP16 was fused in frame with the N-terminus of mouse PPARδ.
T4061	21203-21206	DT	denotes	The
T4063	21207-21222	NN	denotes	transactivation
T4062	21223-21229	NN	denotes	domain
T4065	21230-21231	-LRB-	denotes	(
T4067	21231-21233	CD	denotes	78
T4068	21234-21239	NN	denotes	amino
T4069	21240-21244	NN	denotes	acid
T4066	21245-21253	NNS	denotes	residues
T4070	21253-21255	,	denotes	,
T4071	21255-21268	VBG	denotes	corresponding
T4072	21269-21271	IN	denotes	to
T4073	21272-21280	NNS	denotes	residues
T4074	21281-21284	CD	denotes	413
T4075	21284-21285	SYM	denotes	–
T4076	21285-21288	CD	denotes	490
T4077	21288-21289	-RRB-	denotes	)
T4078	21290-21292	IN	denotes	of
T4079	21293-21297	NN	denotes	VP16
T4080	21298-21301	VBD	denotes	was
T4064	21302-21307	VBN	denotes	fused
T4081	21308-21310	IN	denotes	in
T4082	21311-21316	NN	denotes	frame
T4083	21317-21321	IN	denotes	with
T4084	21322-21325	DT	denotes	the
T4086	21326-21327	NN	denotes	N
T4087	21327-21328	HYPH	denotes	-
T4085	21328-21336	NN	denotes	terminus
T4088	21337-21339	IN	denotes	of
T4089	21340-21345	NN	denotes	mouse
T4090	21346-21351	NN	denotes	PPARδ
T4091	21351-21352	.	denotes	.
T4092	21352-21519	sentence	denotes	The VP16-PPARδ fusion cDNA was placed downstream of the human α-skeletal actin promoter (Brennan and Hardeman 1993), and upstream of the SV40 intron/poly(A) sequence.
T4093	21353-21356	DT	denotes	The
T4095	21357-21361	NN	denotes	VP16
T4097	21361-21362	HYPH	denotes	-
T4096	21362-21367	NN	denotes	PPARδ
T4098	21368-21374	NN	denotes	fusion
T4094	21375-21379	NN	denotes	cDNA
T4100	21380-21383	VBD	denotes	was
T4099	21384-21390	VBN	denotes	placed
T4101	21391-21401	RB	denotes	downstream
T4102	21402-21404	IN	denotes	of
T4103	21405-21408	DT	denotes	the
T4105	21409-21414	JJ	denotes	human
T4106	21415-21416	NN	denotes	α
T4108	21416-21417	HYPH	denotes	-
T4107	21417-21425	JJ	denotes	skeletal
T4109	21426-21431	NN	denotes	actin
T4104	21432-21440	NN	denotes	promoter
T4110	21441-21442	-LRB-	denotes	(
T4111	21442-21449	NNP	denotes	Brennan
T4112	21450-21453	CC	denotes	and
T4113	21454-21462	NNP	denotes	Hardeman
T4114	21463-21467	CD	denotes	1993
T4115	21467-21468	-RRB-	denotes	)
T4116	21468-21470	,	denotes	,
T4117	21470-21473	CC	denotes	and
T4118	21474-21482	RB	denotes	upstream
T4119	21483-21485	IN	denotes	of
T4120	21486-21489	DT	denotes	the
T4122	21490-21494	NN	denotes	SV40
T4123	21495-21501	NN	denotes	intron
T4124	21501-21502	HYPH	denotes	/
T4125	21502-21506	NN	denotes	poly
T4127	21506-21507	-LRB-	denotes	(
T4126	21507-21508	NN	denotes	A
T4128	21508-21509	-RRB-	denotes	)
T4121	21510-21518	NN	denotes	sequence
T4129	21518-21519	.	denotes	.
T4130	21519-21591	sentence	denotes	The transgene was purified and injected into C57BL/6J × CBA F1 zygotes.
T4131	21520-21523	DT	denotes	The
T4132	21524-21533	NN	denotes	transgene
T4134	21534-21537	VBD	denotes	was
T4133	21538-21546	VBN	denotes	purified
T4135	21547-21550	CC	denotes	and
T4136	21551-21559	VBN	denotes	injected
T4137	21560-21564	IN	denotes	into
T4138	21565-21570	NN	denotes	C57BL
T4140	21570-21571	HYPH	denotes	/
T4139	21571-21573	NN	denotes	6J
T4142	21574-21575	SYM	denotes	×
T4143	21576-21579	NN	denotes	CBA
T4144	21580-21582	NN	denotes	F1
T4141	21583-21590	NNS	denotes	zygotes
T4145	21590-21591	.	denotes	.
T4146	21591-21659	sentence	denotes	Transgenic mice were backcrossed with C57BL/6J for two generations.
T4147	21592-21602	JJ	denotes	Transgenic
T4148	21603-21607	NNS	denotes	mice
T4150	21608-21612	VBD	denotes	were
T4149	21613-21624	VBN	denotes	backcrossed
T4151	21625-21629	IN	denotes	with
T4152	21630-21635	NN	denotes	C57BL
T4154	21635-21636	HYPH	denotes	/
T4153	21636-21638	NN	denotes	6J
T4155	21639-21642	IN	denotes	for
T4156	21643-21646	CD	denotes	two
T4157	21647-21658	NNS	denotes	generations
T4158	21658-21659	.	denotes	.
T4159	21659-21725	sentence	denotes	Wild-type littermates were used as controls throughout the study.
T4160	21660-21664	JJ	denotes	Wild
T4162	21664-21665	HYPH	denotes	-
T4161	21665-21669	NN	denotes	type
T4163	21670-21681	NNS	denotes	littermates
T4165	21682-21686	VBD	denotes	were
T4164	21687-21691	VBN	denotes	used
T4166	21692-21694	IN	denotes	as
T4167	21695-21703	NNS	denotes	controls
T4168	21704-21714	IN	denotes	throughout
T4169	21715-21718	DT	denotes	the
T4170	21719-21724	NN	denotes	study
T4171	21724-21725	.	denotes	.
T4172	21725-21826	sentence	denotes	On normal chow diet, the transgenic mice and control littermates used here had similar body weights.
T4173	21726-21728	IN	denotes	On
T4175	21729-21735	JJ	denotes	normal
T4177	21736-21740	NN	denotes	chow
T4176	21741-21745	NN	denotes	diet
T4178	21745-21747	,	denotes	,
T4179	21747-21750	DT	denotes	the
T4181	21751-21761	JJ	denotes	transgenic
T4180	21762-21766	NNS	denotes	mice
T4182	21767-21770	CC	denotes	and
T4183	21771-21778	NN	denotes	control
T4184	21779-21790	NNS	denotes	littermates
T4185	21791-21795	VBN	denotes	used
T4186	21796-21800	RB	denotes	here
T4174	21801-21804	VBD	denotes	had
T4187	21805-21812	JJ	denotes	similar
T4189	21813-21817	NN	denotes	body
T4188	21818-21825	NNS	denotes	weights
T4190	21825-21826	.	denotes	.
T4191	21826-21889	sentence	denotes	PPARδ-null mice were previously generated (Barak et al. 2002).
T4192	21827-21832	NN	denotes	PPARδ
T4194	21832-21833	HYPH	denotes	-
T4193	21833-21837	JJ	denotes	null
T4195	21838-21842	NNS	denotes	mice
T4197	21843-21847	VBD	denotes	were
T4198	21848-21858	RB	denotes	previously
T4196	21859-21868	VBN	denotes	generated
T4199	21869-21870	-LRB-	denotes	(
T4200	21870-21875	NNP	denotes	Barak
T4201	21876-21878	FW	denotes	et
T4202	21879-21882	FW	denotes	al.
T4203	21883-21887	CD	denotes	2002
T4204	21887-21888	-RRB-	denotes	)
T4205	21888-21889	.	denotes	.
T4206	21889-22144	sentence	denotes	Mice were fed either a standard chow with 4% (w/w) fat content (Harlan Teklad, Harlan, Indianapolis, Indiana, United States) or a high-fat diet containing 35% (w/w) fat content (product F3282, Bioserv, Frenchtown, New Jersey, United States) as indicated.
T4207	21890-21894	NNS	denotes	Mice
T4209	21895-21899	VBD	denotes	were
T4208	21900-21903	VBN	denotes	fed
T4210	21904-21910	CC	denotes	either
T4212	21911-21912	DT	denotes	a
T4213	21913-21921	JJ	denotes	standard
T4211	21922-21926	NN	denotes	chow
T4214	21927-21931	IN	denotes	with
T4215	21932-21933	CD	denotes	4
T4216	21933-21934	NN	denotes	%
T4218	21935-21936	-LRB-	denotes	(
T4219	21936-21937	NN	denotes	w
T4220	21937-21938	SYM	denotes	/
T4221	21938-21939	NN	denotes	w
T4222	21939-21940	-RRB-	denotes	)
T4223	21941-21944	NN	denotes	fat
T4217	21945-21952	NN	denotes	content
T4224	21953-21954	-LRB-	denotes	(
T4226	21954-21960	NNP	denotes	Harlan
T4225	21961-21967	NNP	denotes	Teklad
T4227	21967-21969	,	denotes	,
T4228	21969-21975	NNP	denotes	Harlan
T4229	21975-21977	,	denotes	,
T4230	21977-21989	NNP	denotes	Indianapolis
T4231	21989-21991	,	denotes	,
T4232	21991-21998	NNP	denotes	Indiana
T4233	21998-22000	,	denotes	,
T4234	22000-22006	NNP	denotes	United
T4235	22007-22013	NNP	denotes	States
T4236	22013-22014	-RRB-	denotes	)
T4237	22015-22017	CC	denotes	or
T4238	22018-22019	DT	denotes	a
T4240	22020-22024	JJ	denotes	high
T4242	22024-22025	HYPH	denotes	-
T4241	22025-22028	NN	denotes	fat
T4239	22029-22033	NN	denotes	diet
T4243	22034-22044	VBG	denotes	containing
T4244	22045-22047	CD	denotes	35
T4245	22047-22048	NN	denotes	%
T4247	22049-22050	-LRB-	denotes	(
T4248	22050-22051	NN	denotes	w
T4249	22051-22052	SYM	denotes	/
T4250	22052-22053	NN	denotes	w
T4251	22053-22054	-RRB-	denotes	)
T4252	22055-22058	NN	denotes	fat
T4246	22059-22066	NN	denotes	content
T4253	22067-22068	-LRB-	denotes	(
T4255	22068-22075	NN	denotes	product
T4254	22076-22081	NN	denotes	F3282
T4256	22081-22083	,	denotes	,
T4257	22083-22090	NNP	denotes	Bioserv
T4258	22090-22092	,	denotes	,
T4259	22092-22102	NNP	denotes	Frenchtown
T4260	22102-22104	,	denotes	,
T4261	22104-22107	NNP	denotes	New
T4262	22108-22114	NNP	denotes	Jersey
T4263	22114-22116	,	denotes	,
T4264	22116-22122	NNP	denotes	United
T4265	22123-22129	NNP	denotes	States
T4266	22129-22130	-RRB-	denotes	)
T4267	22131-22133	IN	denotes	as
T4268	22134-22143	VBN	denotes	indicated
T4269	22143-22144	.	denotes	.
T4270	22144-22269	sentence	denotes	For ligand experiments, we synthesized the GW501516 compound and mice were orally gavaged daily (10 mg/kg or vehicle alone).
T4271	22145-22148	IN	denotes	For
T4273	22149-22155	NN	denotes	ligand
T4274	22156-22167	NNS	denotes	experiments
T4275	22167-22169	,	denotes	,
T4276	22169-22171	PRP	denotes	we
T4272	22172-22183	VBD	denotes	synthesized
T4277	22184-22187	DT	denotes	the
T4279	22188-22196	NN	denotes	GW501516
T4278	22197-22205	NN	denotes	compound
T4280	22206-22209	CC	denotes	and
T4281	22210-22214	NNS	denotes	mice
T4283	22215-22219	VBD	denotes	were
T4284	22220-22226	RB	denotes	orally
T4282	22227-22234	VBN	denotes	gavaged
T4285	22235-22240	RB	denotes	daily
T4286	22241-22242	-LRB-	denotes	(
T4288	22242-22244	CD	denotes	10
T4287	22245-22247	NNS	denotes	mg
T4289	22247-22248	SYM	denotes	/
T4290	22248-22250	NN	denotes	kg
T4291	22251-22253	CC	denotes	or
T4292	22254-22261	NN	denotes	vehicle
T4293	22262-22267	RB	denotes	alone
T4294	22267-22268	-RRB-	denotes	)
T4295	22268-22269	.	denotes	.
T4318	22271-22275	NN	denotes	Gene
T4319	22276-22286	NN	denotes	expression
T4320	22287-22295	NN	denotes	analysis
T4321	22296-22299	CC	denotes	and
T4322	22300-22313	JJ	denotes	physiological
T4323	22314-22321	NNS	denotes	studies
T4324	22321-22452	sentence	denotes	Mouse EST clones were obtained from ATCC (Manassas, Virginia, United States), verified by sequencing, and used as Northern probes.
T4325	22322-22327	NN	denotes	Mouse
T4327	22328-22331	NN	denotes	EST
T4326	22332-22338	NNS	denotes	clones
T4329	22339-22343	VBD	denotes	were
T4328	22344-22352	VBN	denotes	obtained
T4330	22353-22357	IN	denotes	from
T4331	22358-22362	NN	denotes	ATCC
T4332	22363-22364	-LRB-	denotes	(
T4333	22364-22372	NNP	denotes	Manassas
T4334	22372-22374	,	denotes	,
T4335	22374-22382	NNP	denotes	Virginia
T4336	22382-22384	,	denotes	,
T4337	22384-22390	NNP	denotes	United
T4338	22391-22397	NNP	denotes	States
T4339	22397-22398	-RRB-	denotes	)
T4340	22398-22400	,	denotes	,
T4341	22400-22408	VBN	denotes	verified
T4342	22409-22411	IN	denotes	by
T4343	22412-22422	NN	denotes	sequencing
T4344	22422-22424	,	denotes	,
T4345	22424-22427	CC	denotes	and
T4346	22428-22432	VBN	denotes	used
T4347	22433-22435	IN	denotes	as
T4348	22436-22444	NNP	denotes	Northern
T4349	22445-22451	NNS	denotes	probes
T4350	22451-22452	.	denotes	.
T4351	22452-22548	sentence	denotes	Antibodies were obtained from Santa Cruz Biotechnology (Santa Cruz, California, United States).
T4352	22453-22463	NNS	denotes	Antibodies
T4354	22464-22468	VBD	denotes	were
T4353	22469-22477	VBN	denotes	obtained
T4355	22478-22482	IN	denotes	from
T4356	22483-22488	NNP	denotes	Santa
T4357	22489-22493	NNP	denotes	Cruz
T4358	22494-22507	NNP	denotes	Biotechnology
T4359	22508-22509	-LRB-	denotes	(
T4360	22509-22514	NNP	denotes	Santa
T4361	22515-22519	NNP	denotes	Cruz
T4362	22519-22521	,	denotes	,
T4363	22521-22531	NNP	denotes	California
T4364	22531-22533	,	denotes	,
T4365	22533-22539	NNP	denotes	United
T4366	22540-22546	NNP	denotes	States
T4367	22546-22547	-RRB-	denotes	)
T4368	22547-22548	.	denotes	.
T4369	22548-22664	sentence	denotes	Total muscle protein extracts (Lin et al. 2002) and nuclear proteins (Wang et al. 2003) were prepared as described.
T4370	22549-22554	JJ	denotes	Total
T4372	22555-22561	NN	denotes	muscle
T4373	22562-22569	NN	denotes	protein
T4371	22570-22578	NNS	denotes	extracts
T4375	22579-22580	-LRB-	denotes	(
T4376	22580-22583	NNP	denotes	Lin
T4377	22584-22586	FW	denotes	et
T4378	22587-22590	FW	denotes	al.
T4379	22591-22595	CD	denotes	2002
T4380	22595-22596	-RRB-	denotes	)
T4381	22597-22600	CC	denotes	and
T4382	22601-22608	JJ	denotes	nuclear
T4383	22609-22617	NN	denotes	proteins
T4384	22618-22619	-LRB-	denotes	(
T4385	22619-22623	NNP	denotes	Wang
T4386	22624-22626	FW	denotes	et
T4387	22627-22630	FW	denotes	al.
T4388	22631-22635	CD	denotes	2003
T4389	22635-22636	-RRB-	denotes	)
T4390	22637-22641	VBD	denotes	were
T4374	22642-22650	VBN	denotes	prepared
T4391	22651-22653	IN	denotes	as
T4392	22654-22663	VBN	denotes	described
T4393	22663-22664	.	denotes	.
T4394	22664-22850	sentence	denotes	Prior to the exercise performance test, the mice were accustomed to the treadmill (Columbus Instruments, Columbus, Ohio, United States) with a 5-min run at 7 m/min once per day for 2 d.
T4395	22665-22670	JJ	denotes	Prior
T4396	22671-22673	IN	denotes	to
T4398	22674-22677	DT	denotes	the
T4400	22678-22686	NN	denotes	exercise
T4401	22687-22698	NN	denotes	performance
T4399	22699-22703	NN	denotes	test
T4402	22703-22705	,	denotes	,
T4403	22705-22708	DT	denotes	the
T4404	22709-22713	NNS	denotes	mice
T4405	22714-22718	VBD	denotes	were
T4397	22719-22729	VBN	denotes	accustomed
T4406	22730-22732	IN	denotes	to
T4407	22733-22736	DT	denotes	the
T4408	22737-22746	NN	denotes	treadmill
T4409	22747-22748	-LRB-	denotes	(
T4411	22748-22756	NNP	denotes	Columbus
T4410	22757-22768	NNP	denotes	Instruments
T4412	22768-22770	,	denotes	,
T4413	22770-22778	NNP	denotes	Columbus
T4414	22778-22780	,	denotes	,
T4415	22780-22784	NNP	denotes	Ohio
T4416	22784-22786	,	denotes	,
T4417	22786-22792	NNP	denotes	United
T4418	22793-22799	NNP	denotes	States
T4419	22799-22800	-RRB-	denotes	)
T4420	22801-22805	IN	denotes	with
T4421	22806-22807	DT	denotes	a
T4423	22808-22809	CD	denotes	5
T4425	22809-22810	HYPH	denotes	-
T4424	22810-22813	NN	denotes	min
T4422	22814-22817	NN	denotes	run
T4426	22818-22820	IN	denotes	at
T4427	22821-22822	CD	denotes	7
T4428	22823-22824	NNS	denotes	m
T4429	22824-22825	SYM	denotes	/
T4430	22825-22828	NN	denotes	min
T4431	22829-22833	RB	denotes	once
T4432	22834-22837	IN	denotes	per
T4433	22838-22841	NN	denotes	day
T4434	22842-22845	IN	denotes	for
T4435	22846-22847	CD	denotes	2
T4436	22848-22849	NNS	denotes	d
T4437	22849-22850	.	denotes	.
T4438	22850-22972	sentence	denotes	The exercise test regimen was 10 m/min for the first 60 min, followed by 1 m/min increment increases at 15-min intervals.
T4439	22851-22854	DT	denotes	The
T4441	22855-22863	NN	denotes	exercise
T4442	22864-22868	NN	denotes	test
T4440	22869-22876	NN	denotes	regimen
T4443	22877-22880	VBD	denotes	was
T4444	22881-22883	CD	denotes	10
T4445	22884-22885	NNS	denotes	m
T4446	22885-22886	SYM	denotes	/
T4447	22886-22889	NN	denotes	min
T4448	22890-22893	IN	denotes	for
T4449	22894-22897	DT	denotes	the
T4451	22898-22903	JJ	denotes	first
T4452	22904-22906	CD	denotes	60
T4450	22907-22910	NN	denotes	min
T4453	22910-22912	,	denotes	,
T4454	22912-22920	VBN	denotes	followed
T4455	22921-22923	IN	denotes	by
T4456	22924-22925	CD	denotes	1
T4457	22926-22927	NN	denotes	m
T4459	22927-22928	SYM	denotes	/
T4460	22928-22931	NN	denotes	min
T4458	22932-22941	NN	denotes	increment
T4461	22942-22951	VBZ	denotes	increases
T4462	22952-22954	IN	denotes	at
T4463	22955-22957	CD	denotes	15
T4465	22957-22958	HYPH	denotes	-
T4464	22958-22961	NN	denotes	min
T4466	22962-22971	NNS	denotes	intervals
T4467	22971-22972	.	denotes	.
T4468	22972-23056	sentence	denotes	Exhaustion was defined when mice were unable to avoid repetitive electrical shocks.
T4469	22973-22983	NN	denotes	Exhaustion
T4471	22984-22987	VBD	denotes	was
T4470	22988-22995	VBN	denotes	defined
T4472	22996-23000	WRB	denotes	when
T4474	23001-23005	NNS	denotes	mice
T4473	23006-23010	VBD	denotes	were
T4475	23011-23017	JJ	denotes	unable
T4476	23018-23020	TO	denotes	to
T4477	23021-23026	VB	denotes	avoid
T4478	23027-23037	JJ	denotes	repetitive
T4480	23038-23048	JJ	denotes	electrical
T4479	23049-23055	NNS	denotes	shocks
T4481	23055-23056	.	denotes	.
T4506	23058-23064	NN	denotes	Muscle
T4507	23065-23070	NN	denotes	fiber
T4508	23071-23077	NN	denotes	typing
T4509	23078-23081	CC	denotes	and
T4510	23082-23095	JJ	denotes	mitochondrial
T4511	23096-23099	NN	denotes	DNA
T4512	23100-23109	NN	denotes	isolation
T4513	23109-23235	sentence	denotes	Muscle fiber typing was essentially performed using metachromatic dye–ATPase methods as described (Ogilvie and Feeback 1990).
T4514	23110-23116	NN	denotes	Muscle
T4515	23117-23122	NN	denotes	fiber
T4516	23123-23129	NN	denotes	typing
T4518	23130-23133	VBD	denotes	was
T4519	23134-23145	RB	denotes	essentially
T4517	23146-23155	VBN	denotes	performed
T4520	23156-23161	VBG	denotes	using
T4521	23162-23175	JJ	denotes	metachromatic
T4522	23176-23179	NN	denotes	dye
T4524	23179-23180	HYPH	denotes	–
T4525	23180-23186	NN	denotes	ATPase
T4523	23187-23194	NNS	denotes	methods
T4526	23195-23197	IN	denotes	as
T4527	23198-23207	VBN	denotes	described
T4528	23208-23209	-LRB-	denotes	(
T4529	23209-23216	NNP	denotes	Ogilvie
T4530	23217-23220	CC	denotes	and
T4531	23221-23228	NNP	denotes	Feeback
T4532	23229-23233	CD	denotes	1990
T4533	23233-23234	-RRB-	denotes	)
T4534	23234-23235	.	denotes	.
T4535	23235-23292	sentence	denotes	Muscle mitochondria were isolated (Scholte et al. 1997).
T4536	23236-23242	NN	denotes	Muscle
T4537	23243-23255	NNS	denotes	mitochondria
T4539	23256-23260	VBD	denotes	were
T4538	23261-23269	VBN	denotes	isolated
T4540	23270-23271	-LRB-	denotes	(
T4541	23271-23278	NNP	denotes	Scholte
T4542	23279-23281	FW	denotes	et
T4543	23282-23285	FW	denotes	al.
T4544	23286-23290	CD	denotes	1997
T4545	23290-23291	-RRB-	denotes	)
T4546	23291-23292	.	denotes	.
T4547	23292-23355	sentence	denotes	Mitochondrial DNA was prepared and analyzed on 1% agarose gel.
T4548	23293-23306	JJ	denotes	Mitochondrial
T4549	23307-23310	NN	denotes	DNA
T4551	23311-23314	VBD	denotes	was
T4550	23315-23323	VBN	denotes	prepared
T4552	23324-23327	CC	denotes	and
T4553	23328-23336	VBN	denotes	analyzed
T4554	23337-23339	IN	denotes	on
T4555	23340-23341	CD	denotes	1
T4556	23341-23342	NN	denotes	%
T4558	23343-23350	NN	denotes	agarose
T4557	23351-23354	NN	denotes	gel
T4559	23354-23355	.	denotes	.
T4562	23357-23368	JJ	denotes	Statistical
T4563	23369-23377	NN	denotes	analysis
T4564	23377-23459	sentence	denotes	Number of mice for each group used in experiments is indicated in figure legends.
T4565	23378-23384	NN	denotes	Number
T4567	23385-23387	IN	denotes	of
T4568	23388-23392	NNS	denotes	mice
T4569	23393-23396	IN	denotes	for
T4570	23397-23401	DT	denotes	each
T4571	23402-23407	NN	denotes	group
T4572	23408-23412	VBN	denotes	used
T4573	23413-23415	IN	denotes	in
T4574	23416-23427	NNS	denotes	experiments
T4575	23428-23430	VBZ	denotes	is
T4566	23431-23440	VBN	denotes	indicated
T4576	23441-23443	IN	denotes	in
T4577	23444-23450	NN	denotes	figure
T4578	23451-23458	NNS	denotes	legends
T4579	23458-23459	.	denotes	.
T4580	23459-23495	sentence	denotes	Values are presented as mean ± SEM.
T4581	23460-23466	NNS	denotes	Values
T4583	23467-23470	VBP	denotes	are
T4582	23471-23480	VBN	denotes	presented
T4584	23481-23483	IN	denotes	as
T4585	23484-23488	NN	denotes	mean
T4587	23489-23490	SYM	denotes	±
T4586	23491-23494	NN	denotes	SEM
T4588	23494-23495	.	denotes	.
T4589	23495-23557	sentence	denotes	A two-tailed Student's t test was used to calculate p-values.
T4590	23496-23497	DT	denotes	A
T4592	23498-23501	CD	denotes	two
T4594	23501-23502	HYPH	denotes	-
T4593	23502-23508	VBN	denotes	tailed
T4595	23509-23516	NNP	denotes	Student
T4596	23516-23518	POS	denotes	's
T4597	23519-23520	NN	denotes	t
T4591	23521-23525	NN	denotes	test
T4599	23526-23529	VBD	denotes	was
T4598	23530-23534	VBN	denotes	used
T4600	23535-23537	TO	denotes	to
T4601	23538-23547	VB	denotes	calculate
T4602	23548-23549	NN	denotes	p
T4604	23549-23550	HYPH	denotes	-
T4603	23550-23556	NNS	denotes	values
T4605	23556-23557	.	denotes	.
R1	T112	T109	dobj	process,direct
R10	T123	T122	prep	of,capable
R100	T70	T61	prep	by,Regulation
R1000	T1571	T1548	prep	in,produced
R1001	T1572	T1573	amod	wild,type
R1002	T1573	T1575	compound	type,littermates
R1003	T1574	T1573	punct	-,type
R1004	T1575	T1571	pobj	littermates,in
R1005	T1576	T1548	punct	.,produced
R1006	T1578	T1579	advmod	Interestingly,was
R1007	T1580	T1579	punct	", ",was
R1008	T1581	T1582	det	the,level
R1009	T1582	T1579	nsubj	level,was
R101	T71	T70	pobj	PPARδ,by
R1010	T1583	T1582	prep	of,level
R1011	T1584	T1585	amod	endogenous,protein
R1012	T1585	T1583	pobj	protein,of
R1013	T1586	T1585	compound	muscle,protein
R1014	T1587	T1585	compound	PPARδ,protein
R1015	T1588	T1582	prep	in,level
R1016	T1589	T1590	det	the,mice
R1017	T1590	T1588	pobj	mice,in
R1018	T1591	T1590	amod	transgenic,mice
R1019	T1592	T1593	advmod	much,higher
R102	T74	T75	compound	Endurance,training
R1020	T1593	T1579	acomp	higher,was
R1021	T1594	T1593	prep	than,higher
R1022	T1595	T1594	prep	in,than
R1023	T1596	T1597	det	the,littermates
R1024	T1597	T1595	pobj	littermates,in
R1025	T1598	T1597	compound	control,littermates
R1026	T1599	T1579	punct	.,was
R1027	T1601	T1602	det	The,increase
R1028	T1602	T1604	nsubjpass	increase,caused
R1029	T1603	T1602	amod	substantial,increase
R103	T75	T77	nsubj	training,promote
R1030	T1605	T1602	prep	of,increase
R1031	T1606	T1607	amod	endogenous,PPARδ
R1032	T1607	T1605	pobj	PPARδ,of
R1033	T1608	T1604	aux	may,caused
R1034	T1609	T1604	aux	have,caused
R1035	T1610	T1604	auxpass	been,caused
R1036	T1611	T1604	agent	by,caused
R1037	T1612	T1613	det	a,switch
R1038	T1613	T1611	pobj	switch,by
R1039	T1614	T1613	prep	to,switch
R104	T76	T75	compound	exercise,training
R1040	T1615	T1616	nmod	type,fiber
R1041	T1616	T1614	pobj	fiber,to
R1042	T1617	T1615	nummod	I,type
R1043	T1618	T1619	punct	(,see
R1044	T1619	T1616	parataxis	see,fiber
R1045	T1620	T1619	advmod	below,see
R1046	T1621	T1619	punct	),see
R1047	T1622	T1616	punct	", ",fiber
R1048	T1623	T1624	dep	which,expresses
R1049	T1624	T1616	relcl	expresses,fiber
R105	T78	T77	aux	can,promote
R1050	T1625	T1624	advmod	intrinsically,expresses
R1051	T1626	T1627	amod	higher,levels
R1052	T1627	T1624	dobj	levels,expresses
R1053	T1628	T1627	prep	of,levels
R1054	T1629	T1628	pobj	PPARδ,of
R1055	T1630	T1631	punct	(,1A
R1056	T1631	T1624	parataxis	1A,expresses
R1057	T1632	T1631	nmod	Figure,1A
R1058	T1633	T1631	cc	and,1A
R1059	T1634	T1631	conj	1B,1A
R106	T79	T80	det	an,transformation
R1060	T1635	T1631	punct	),1A
R1061	T1636	T1604	punct	.,caused
R1062	T1638	T1639	nmod	Type,muscle
R1063	T1639	T1641	nsubjpass	muscle,distinguished
R1064	T1640	T1638	nummod	I,Type
R1065	T1642	T1641	aux	can,distinguished
R1066	T1643	T1641	auxpass	be,distinguished
R1067	T1644	T1641	advmod	readily,distinguished
R1068	T1645	T1641	prep	from,distinguished
R1069	T1646	T1647	nmod	type,muscle
R107	T80	T77	dobj	transformation,promote
R1070	T1647	T1645	pobj	muscle,from
R1071	T1648	T1646	nummod	II,type
R1072	T1649	T1646	cc	or,type
R1073	T1650	T1646	conj	mixed,type
R1074	T1651	T1641	prep	by,distinguished
R1075	T1652	T1653	poss	its,color
R1076	T1653	T1651	pobj	color,by
R1077	T1654	T1653	amod	red,color
R1078	T1655	T1641	punct	", ",distinguished
R1079	T1656	T1641	prep	because,distinguished
R108	T81	T80	amod	adaptive,transformation
R1080	T1657	T1656	prep	of,because
R1081	T1658	T1659	poss	its,concentration
R1082	T1659	T1657	pobj	concentration,of
R1083	T1660	T1659	amod	high,concentration
R1084	T1661	T1659	prep	of,concentration
R1085	T1662	T1661	pobj	myoglobin,of
R1086	T1663	T1662	punct	", ",myoglobin
R1087	T1664	T1665	det	a,protein
R1088	T1665	T1662	appos	protein,myoglobin
R1089	T1666	T1667	advmod	typically,expressed
R109	T82	T83	compound	muscle,fiber
R1090	T1667	T1665	acl	expressed,protein
R1091	T1668	T1667	prep	in,expressed
R1092	T1669	T1670	amod	oxidative,fibers
R1093	T1670	T1668	pobj	fibers,in
R1094	T1671	T1670	compound	muscle,fibers
R1095	T1672	T1641	punct	.,distinguished
R1096	T1674	T1675	nsubj	We,found
R1097	T1676	T1677	mark	that,appeared
R1098	T1677	T1675	ccomp	appeared,found
R1099	T1678	T1677	nsubj	muscles,appeared
R11	T124	T125	amod	continuous,running
R110	T83	T80	compound	fiber,transformation
R1100	T1679	T1678	prep	in,muscles
R1101	T1680	T1681	det	the,mice
R1102	T1681	T1679	pobj	mice,in
R1103	T1682	T1681	amod	transgenic,mice
R1104	T1683	T1677	oprd	redder,appeared
R1105	T1684	T1685	punct	(,Figure
R1106	T1685	T1677	parataxis	Figure,appeared
R1107	T1686	T1685	nummod	2A,Figure
R1108	T1687	T1685	punct	),Figure
R1109	T1688	T1677	punct	", ",appeared
R111	T84	T80	cc	and,transformation
R1110	T1689	T1690	dep	which,is
R1111	T1690	T1677	advcl	is,appeared
R1112	T1691	T1692	advmod	particularly,evident
R1113	T1692	T1690	acomp	evident,is
R1114	T1693	T1690	prep	in,is
R1115	T1694	T1695	det	the,fibers
R1116	T1695	T1693	pobj	fibers,in
R1117	T1696	T1697	amod	mixed,II
R1118	T1697	T1695	nummod	II,fibers
R1119	T1698	T1697	nmod	type,II
R112	T85	T86	det	an,increase
R1120	T1699	T1697	nummod	I,II
R1121	T1700	T1697	punct	/,II
R1122	T1701	T1695	prep	of,fibers
R1123	T1702	T1703	det	the,hindlimb
R1124	T1703	T1701	pobj	hindlimb,of
R1125	T1704	T1705	punct	(,Figure
R1126	T1705	T1690	parataxis	Figure,is
R1127	T1706	T1705	nummod	2B,Figure
R1128	T1707	T1705	punct	),Figure
R1129	T1708	T1675	punct	.,found
R113	T86	T80	conj	increase,transformation
R1130	T1710	T1711	advmod	Indeed,revealed
R1131	T1712	T1711	punct	", ",revealed
R1132	T1713	T1714	amod	metachromatic,staining
R1133	T1714	T1711	nsubj	staining,revealed
R1134	T1715	T1716	det	a,transformation
R1135	T1716	T1711	dobj	transformation,revealed
R1136	T1717	T1716	amod	substantial,transformation
R1137	T1718	T1719	compound	muscle,fiber
R1138	T1719	T1716	compound	fiber,transformation
R1139	T1720	T1721	punct	(,Figure
R114	T87	T86	prep	of,increase
R1140	T1721	T1711	parataxis	Figure,revealed
R1141	T1722	T1721	nummod	2C,Figure
R1142	T1723	T1721	punct	),Figure
R1143	T1724	T1711	punct	.,revealed
R1144	T1726	T1727	prep	In,estimated
R1145	T1728	T1729	compound	gastrocnemius,muscle
R1146	T1729	T1726	pobj	muscle,In
R1147	T1730	T1727	punct	", ",estimated
R1148	T1731	T1727	nsubj	we,estimated
R1149	T1732	T1733	mark	that,was
R115	T88	T89	amod	mitochondrial,biogenesis
R1150	T1733	T1727	ccomp	was,estimated
R1151	T1734	T1733	expl	there,was
R1152	T1735	T1736	det	a,increase
R1153	T1736	T1733	attr	increase,was
R1154	T1737	T1736	amod	2-fold,increase
R1155	T1738	T1736	prep	of,increase
R1156	T1739	T1740	nmod	type,fibers
R1157	T1740	T1738	pobj	fibers,of
R1158	T1741	T1739	nummod	I,type
R1159	T1742	T1727	punct	.,estimated
R116	T89	T87	pobj	biogenesis,of
R1160	T1744	T1745	det	A,component
R1161	T1745	T1747	nsubj	component,is
R1162	T1746	T1745	amod	diagnostic,component
R1163	T1748	T1745	prep	of,component
R1164	T1749	T1750	amod	oxidative,fibers
R1165	T1750	T1748	pobj	fibers,of
R1166	T1751	T1752	poss	their,content
R1167	T1752	T1747	attr	content,is
R1168	T1753	T1752	amod	high,content
R1169	T1754	T1752	nmod	myoglobin,content
R117	T90	T77	prep	by,promote
R1170	T1755	T1754	cc	and,myoglobin
R1171	T1756	T1754	conj	mitochondrial,myoglobin
R1172	T1757	T1752	punct	", ",content
R1173	T1758	T1759	dep	which,supported
R1174	T1759	T1752	relcl	supported,content
R1175	T1760	T1759	auxpass	is,supported
R1176	T1761	T1759	agent	by,supported
R1177	T1762	T1763	det	the,analysis
R1178	T1763	T1761	pobj	analysis,by
R1179	T1764	T1763	compound	mRNA,analysis
R118	T91	T90	pcomp	triggering,by
R1180	T1765	T1763	acl	shown,analysis
R1181	T1766	T1765	prep	in,shown
R1182	T1767	T1766	pobj	Figure,in
R1183	T1768	T1767	nummod	3A,Figure
R1184	T1769	T1747	punct	.,is
R1185	T1771	T1772	prep	In,elevated
R1186	T1773	T1771	pobj	addition,In
R1187	T1774	T1773	prep	to,addition
R1188	T1775	T1774	pobj	myoglobin,to
R1189	T1776	T1772	punct	", ",elevated
R119	T92	T93	amod	scripted,changes
R1190	T1777	T1778	amod	mitochondrial,components
R1191	T1778	T1772	nsubjpass	components,elevated
R1192	T1779	T1778	prep	for,components
R1193	T1780	T1781	compound	electron,transfer
R1194	T1781	T1779	pobj	transfer,for
R1195	T1782	T1783	punct	(,c
R1196	T1783	T1778	parataxis	c,components
R1197	T1784	T1783	compound	cytochrome,c
R1198	T1785	T1783	cc	and,c
R1199	T1786	T1787	compound	cytochrome,c
R12	T125	T123	pobj	running,of
R120	T93	T91	dobj	changes,triggering
R1200	T1787	T1788	compound	c,oxidase
R1201	T1788	T1783	conj	oxidase,c
R1202	T1789	T1790	punct	[,COX
R1203	T1790	T1788	parataxis	COX,oxidase
R1204	T1791	T1790	punct	],COX
R1205	T1792	T1783	appos	II,c
R1206	T1793	T1792	cc	and,II
R1207	T1794	T1792	conj	IV,II
R1208	T1795	T1783	punct	),c
R1209	T1796	T1778	cc	and,components
R121	T94	T91	prep	in,triggering
R1210	T1797	T1798	amod	fatty,acid
R1211	T1798	T1800	compound	acid,enzymes
R1212	T1799	T1798	punct	-,acid
R1213	T1800	T1778	conj	enzymes,components
R1214	T1801	T1802	compound	β,oxidation
R1215	T1802	T1800	compound	oxidation,enzymes
R1216	T1803	T1802	punct	-,oxidation
R1217	T1804	T1772	auxpass	were,elevated
R1218	T1805	T1806	punct	(,data
R1219	T1806	T1772	parataxis	data,elevated
R122	T95	T96	compound	gene,expression
R1220	T1807	T1806	dep	Figure,data
R1221	T1808	T1807	nummod	3A,Figure
R1222	T1809	T1806	punct	;,data
R1223	T1810	T1806	amod	unpublished,data
R1224	T1811	T1806	punct	),data
R1225	T1812	T1772	punct	.,elevated
R1226	T1814	T1815	det	These,effects
R1227	T1815	T1816	nsubj	effects,appear
R1228	T1817	T1818	aux	to,be
R1229	T1818	T1816	xcomp	be,appear
R123	T96	T94	pobj	expression,in
R1230	T1819	T1820	amod	direct,consequences
R1231	T1820	T1818	attr	consequences,be
R1232	T1821	T1820	prep	of,consequences
R1233	T1822	T1823	compound	PPARδ,activation
R1234	T1823	T1821	pobj	activation,of
R1235	T1824	T1818	punct	", ",be
R1236	T1825	T1826	mark	as,remained
R1237	T1826	T1818	advcl	remained,be
R1238	T1827	T1826	nsubj	levels,remained
R1239	T1828	T1827	prep	of,levels
R124	T97	T77	punct	.,promote
R1240	T1829	T1828	pobj	PGC,of
R1241	T1830	T1829	punct	-,PGC
R1242	T1831	T1829	nummod	1α,PGC
R1243	T1832	T1829	punct	", ",PGC
R1244	T1833	T1834	det	a,coactivator
R1245	T1834	T1829	appos	coactivator,PGC
R1246	T1835	T1834	acl	involved,coactivator
R1247	T1836	T1835	prep	in,involved
R1248	T1837	T1838	compound	muscle,fiber
R1249	T1838	T1839	compound	fiber,switch
R125	T99	T100	advmod	However,identified
R1250	T1839	T1836	pobj	switch,in
R1251	T1840	T1839	cc	and,switch
R1252	T1841	T1842	amod	mitochondrial,biogenesis
R1253	T1842	T1839	conj	biogenesis,switch
R1254	T1843	T1844	punct	(,Wu
R1255	T1844	T1835	meta	Wu,involved
R1256	T1845	T1844	nmod	et,Wu
R1257	T1846	T1844	nmod	al.,Wu
R1258	T1847	T1844	nummod	1999,Wu
R1259	T1848	T1844	punct	;,Wu
R126	T101	T100	punct	", ",identified
R1260	T1849	T1844	nmod	Lehman,Wu
R1261	T1850	T1844	nmod	et,Wu
R1262	T1851	T1844	nmod	al.,Wu
R1263	T1852	T1844	nummod	2000,Wu
R1264	T1853	T1844	punct	;,Wu
R1265	T1854	T1844	nmod	Lin,Wu
R1266	T1855	T1844	nmod	et,Wu
R1267	T1856	T1844	nmod	al.,Wu
R1268	T1857	T1844	nummod	2002,Wu
R1269	T1858	T1844	punct	),Wu
R127	T102	T103	det	no,factor
R1270	T1859	T1826	punct	", ",remained
R1271	T1860	T1826	oprd	unchanged,remained
R1272	T1861	T1816	punct	.,appear
R1273	T1863	T1864	compound	Southern,blot
R1274	T1864	T1865	compound	blot,analysis
R1275	T1865	T1866	nsubj	analysis,detected
R1276	T1867	T1868	det	a,number
R1277	T1868	T1866	dobj	number,detected
R1278	T1869	T1870	advmod	substantially,higher
R1279	T1870	T1868	amod	higher,number
R128	T103	T100	nsubjpass	factor,identified
R1280	T1871	T1868	compound	copy,number
R1281	T1872	T1868	prep	of,number
R1282	T1873	T1874	det	the,DNA
R1283	T1874	T1872	pobj	DNA,of
R1284	T1875	T1874	amod	mitochondrial,DNA
R1285	T1876	T1877	npadvmod	genome,encoded
R1286	T1877	T1874	amod	encoded,DNA
R1287	T1878	T1877	punct	–,encoded
R1288	T1879	T1874	compound	COXII,DNA
R1289	T1880	T1866	prep	in,detected
R129	T104	T103	compound	transcription,factor
R1290	T1881	T1882	det	the,mice
R1291	T1882	T1880	pobj	mice,in
R1292	T1883	T1882	amod	transgenic,mice
R1293	T1884	T1885	punct	(,Figure
R1294	T1885	T1866	parataxis	Figure,detected
R1295	T1886	T1885	nummod	3B,Figure
R1296	T1887	T1885	punct	),Figure
R1297	T1888	T1866	punct	.,detected
R1298	T1890	T1891	amod	Mitochondrial,DNA
R1299	T1891	T1892	nsubjpass	DNA,increased
R13	T126	T125	prep	of,running
R130	T105	T100	aux	has,identified
R1300	T1893	T1892	auxpass	was,increased
R1301	T1894	T1892	advmod	2.3,increased
R1302	T1895	T1894	punct	-,2.3
R1303	T1896	T1894	advmod	fold,2.3
R1304	T1897	T1892	prep	in,increased
R1305	T1898	T1899	compound	gastrocnemius,muscle
R1306	T1899	T1897	pobj	muscle,in
R1307	T1900	T1899	prep	of,muscle
R1308	T1901	T1902	det	the,mice
R1309	T1902	T1900	pobj	mice,of
R131	T106	T100	advmod	yet,identified
R1310	T1903	T1902	amod	transgenic,mice
R1311	T1904	T1905	punct	(,Figure
R1312	T1905	T1892	parataxis	Figure,increased
R1313	T1906	T1905	nummod	3C,Figure
R1314	T1907	T1905	punct	),Figure
R1315	T1908	T1892	punct	.,increased
R1316	T1910	T1911	det	These,results
R1317	T1911	T1912	nsubj	results,reveal
R1318	T1913	T1914	det	a,stimulation
R1319	T1914	T1912	dobj	stimulation,reveal
R132	T107	T100	auxpass	been,identified
R1320	T1915	T1914	amod	marked,stimulation
R1321	T1916	T1914	prep	of,stimulation
R1322	T1917	T1918	amod	mitochondrial,biogenesis
R1323	T1918	T1916	pobj	biogenesis,of
R1324	T1919	T1912	cc	and,reveal
R1325	T1920	T1921	advmod	further,support
R1326	T1921	T1912	conj	support,reveal
R1327	T1922	T1923	det	the,idea
R1328	T1923	T1921	dobj	idea,support
R1329	T1924	T1925	mark	that,is
R133	T108	T109	dep	that,direct
R1330	T1925	T1923	acl	is,idea
R1331	T1926	T1925	expl	there,is
R1332	T1927	T1928	det	a,switch
R1333	T1928	T1925	attr	switch,is
R1334	T1929	T1930	compound	muscle,fiber
R1335	T1930	T1928	compound	fiber,switch
R1336	T1931	T1912	punct	.,reveal
R1337	T1933	T1934	det	This,conclusion
R1338	T1934	T1935	nsubjpass	conclusion,confirmed
R1339	T1936	T1935	auxpass	was,confirmed
R134	T109	T100	ccomp	direct,identified
R1340	T1937	T1935	advmod	also,confirmed
R1341	T1938	T1935	prep	by,confirmed
R1342	T1939	T1940	compound	Western,blot
R1343	T1940	T1941	compound	blot,analysis
R1344	T1941	T1938	pobj	analysis,by
R1345	T1942	T1935	punct	.,confirmed
R1346	T1944	T1945	mark	As,shown
R1347	T1945	T1946	advcl	shown,increased
R1348	T1947	T1945	prep	in,shown
R1349	T1948	T1947	pobj	Figure,in
R135	T110	T109	aux	can,direct
R1350	T1949	T1948	nummod	3D,Figure
R1351	T1950	T1946	punct	", ",increased
R1352	T1951	T1952	det	the,proteins
R1353	T1952	T1946	nsubjpass	proteins,increased
R1354	T1953	T1952	amod	characteristic,proteins
R1355	T1954	T1955	nmod	type,fiber
R1356	T1955	T1952	compound	fiber,proteins
R1357	T1956	T1954	nummod	I,type
R1358	T1957	T1952	punct	", ",proteins
R1359	T1958	T1959	amod	such,as
R136	T111	T112	det	this,process
R1360	T1959	T1952	prep	as,proteins
R1361	T1960	T1959	pobj	myoglobin,as
R1362	T1961	T1960	cc	and,myoglobin
R1363	T1962	T1963	nmod	cytochrome,b
R1364	T1963	T1960	conj	b,myoglobin
R1365	T1964	T1963	nmod	c,b
R1366	T1965	T1964	cc	and,c
R1367	T1966	T1946	punct	", ",increased
R1368	T1967	T1946	auxpass	were,increased
R1369	T1968	T1946	advmod	significantly,increased
R137	T165	T148	relcl	induces,form
R1370	T1969	T1946	punct	.,increased
R1371	T1971	T1972	advmod	More,importantly
R1372	T1972	T1973	advmod	importantly,induced
R1373	T1973	T1990	ccomp	induced,accompanied
R1374	T1974	T1973	punct	", ",induced
R1375	T1975	T1976	det	the,protein
R1376	T1976	T1973	nsubjpass	protein,induced
R1377	T1977	T1976	amod	specialized,protein
R1378	T1978	T1976	compound	contraction,protein
R1379	T1979	T1976	appos	troponin,protein
R138	T166	T167	det	a,switch
R1380	T1980	T1979	nummod	I,troponin
R1381	T1981	T1982	punct	(,slow
R1382	T1982	T1976	parataxis	slow,protein
R1383	T1983	T1982	punct	),slow
R1384	T1984	T1976	prep	of,protein
R1385	T1985	T1986	nmod	type,fiber
R1386	T1986	T1984	pobj	fiber,of
R1387	T1987	T1985	nummod	I,type
R1388	T1988	T1973	auxpass	was,induced
R1389	T1989	T1973	advmod	robustly,induced
R139	T167	T165	dobj	switch,induces
R1390	T1991	T1990	punct	;,accompanied
R1391	T1992	T1990	nsubjpass	this,accompanied
R1392	T1993	T1990	auxpass	was,accompanied
R1393	T1994	T1990	agent	by,accompanied
R1394	T1995	T1996	det	a,reduction
R1395	T1996	T1994	pobj	reduction,by
R1396	T1997	T1996	amod	marked,reduction
R1397	T1998	T1996	prep	of,reduction
R1398	T1999	T2000	det	the,protein
R1399	T2000	T1998	pobj	protein,of
R14	T127	T128	advmod	up,twice
R140	T168	T169	aux	to,form
R1400	T2001	T2000	amod	specialized,protein
R1401	T2002	T2000	compound	contraction,protein
R1402	T2003	T2000	appos	troponin,protein
R1403	T2004	T2003	nummod	I,troponin
R1404	T2005	T2006	punct	(,fast
R1405	T2006	T2003	parataxis	fast,troponin
R1406	T2007	T2006	punct	),fast
R1407	T2008	T2000	prep	of,protein
R1408	T2009	T2010	nmod	type,fiber
R1409	T2010	T2008	pobj	fiber,of
R141	T169	T167	advcl	form,switch
R1410	T2011	T2009	nummod	II,type
R1411	T2012	T1990	punct	", ",accompanied
R1412	T2013	T1990	advcl	indicating,accompanied
R1413	T2014	T2015	det	a,degree
R1414	T2015	T2013	dobj	degree,indicating
R1415	T2016	T2015	amod	high,degree
R1416	T2017	T2015	prep	of,degree
R1417	T2018	T2019	compound	fiber,transformation
R1418	T2019	T2017	pobj	transformation,of
R1419	T2020	T1990	punct	.,accompanied
R142	T170	T171	amod	increased,numbers
R1420	T2022	T2023	nsubj	We,examined
R1421	T2024	T2023	advmod	next,examined
R1422	T2025	T2026	mark	whether,induce
R1423	T2026	T2023	ccomp	induce,examined
R1424	T2027	T2028	amod	acute,activation
R1425	T2028	T2026	nsubj	activation,induce
R1426	T2029	T2028	prep	of,activation
R1427	T2030	T2031	amod	endogenous,PPARδ
R1428	T2031	T2029	pobj	PPARδ,of
R1429	T2032	T2026	aux	would,induce
R143	T171	T169	dobj	numbers,form
R1430	T2033	T2034	amod	similar,genes
R1431	T2034	T2026	dobj	genes,induce
R1432	T2035	T2034	compound	target,genes
R1433	T2036	T2023	punct	.,examined
R1434	T2038	T2039	prep	In,found
R1435	T2040	T2038	pobj	agreement,In
R1436	T2041	T2040	prep	with,agreement
R1437	T2042	T2043	det	the,effects
R1438	T2043	T2041	pobj	effects,with
R1439	T2044	T2043	amod	chronic,effects
R144	T172	T171	prep	of,numbers
R1440	T2045	T2043	prep	in,effects
R1441	T2046	T2047	det	the,mice
R1442	T2047	T2045	pobj	mice,in
R1443	T2048	T2047	amod	transgenic,mice
R1444	T2049	T2039	punct	", ",found
R1445	T2050	T2039	nsubj	we,found
R1446	T2051	T2052	mark	that,upregulated
R1447	T2052	T2039	ccomp	upregulated,found
R1448	T2053	T2052	punct	", ",upregulated
R1449	T2054	T2052	prep	after,upregulated
R145	T173	T174	nmod	type,fibers
R1450	T2055	T2054	pobj	treatment,after
R1451	T2056	T2055	prep	of,treatment
R1452	T2057	T2058	amod	wild,type
R1453	T2058	T2060	compound	type,mice
R1454	T2059	T2058	punct	-,type
R1455	T2060	T2056	pobj	mice,of
R1456	T2061	T2060	compound	C57B6J,mice
R1457	T2062	T2055	prep	with,treatment
R1458	T2063	T2064	det	the,GW501516
R1459	T2064	T2062	pobj	GW501516,with
R146	T174	T172	pobj	fibers,of
R1460	T2065	T2066	npadvmod	PPARδ,specific
R1461	T2066	T2064	amod	specific,GW501516
R1462	T2067	T2066	punct	-,specific
R1463	T2068	T2064	compound	agonist,GW501516
R1464	T2069	T2055	prep	for,treatment
R1465	T2070	T2071	advmod	only,d
R1466	T2071	T2069	pobj	d,for
R1467	T2072	T2071	nummod	10,d
R1468	T2073	T2052	punct	", ",upregulated
R1469	T2074	T2052	nsubjpass	genes,upregulated
R147	T175	T173	nummod	I,type
R1470	T2075	T2074	prep	for,genes
R1471	T2076	T2077	amod	slow,fiber
R1472	T2077	T2078	nmod	fiber,proteins
R1473	T2078	T2075	pobj	proteins,for
R1474	T2079	T2078	amod	contractile,proteins
R1475	T2080	T2078	punct	", ",proteins
R1476	T2081	T2082	amod	mitochondrial,biogenesis
R1477	T2082	T2078	conj	biogenesis,proteins
R1478	T2083	T2082	punct	", ",biogenesis
R1479	T2084	T2082	cc	and,biogenesis
R148	T176	T174	compound	muscle,fibers
R1480	T2085	T2086	compound	β,oxidation
R1481	T2086	T2082	conj	oxidation,biogenesis
R1482	T2087	T2086	punct	-,oxidation
R1483	T2088	T2052	auxpass	were,upregulated
R1484	T2089	T2052	advmod	all,upregulated
R1485	T2090	T2091	punct	(,Figure
R1486	T2092	T2091	nummod	3E,Figure
R1487	T2091	T2052	parataxis	Figure,upregulated
R1488	T2093	T2091	punct	),Figure
R1489	T2094	T2039	punct	.,found
R149	T177	T141	punct	.,achieved
R1490	T2096	T2097	nsubj	This,indicates
R1491	T2098	T2099	mark	that,achieved
R1492	T2099	T2097	ccomp	achieved,indicates
R1493	T2100	T2101	amod	rapid,changes
R1494	T2101	T2099	nsubjpass	changes,achieved
R1495	T2102	T2100	punct	", ",rapid
R1496	T2103	T2100	conj	systematic,rapid
R1497	T2104	T2103	punct	", ",systematic
R1498	T2105	T2103	cc	and,systematic
R1499	T2106	T2103	conj	coordinated,systematic
R15	T128	T130	nummod	twice,distance
R150	T179	T180	nsubj	Treatment,elicits
R1500	T2107	T2101	prep	of,changes
R1501	T2108	T2109	compound	muscle,properties
R1502	T2109	T2107	pobj	properties,of
R1503	T2110	T2109	compound	fiber,properties
R1504	T2111	T2101	prep	toward,changes
R1505	T2112	T2111	pobj	type,toward
R1506	T2113	T2112	nummod	I,type
R1507	T2114	T2099	aux	can,achieved
R1508	T2115	T2099	auxpass	be,achieved
R1509	T2116	T2099	prep	by,achieved
R151	T181	T179	prep	of,Treatment
R1510	T2117	T2116	pobj	activation,by
R1511	T2118	T2117	prep	of,activation
R1512	T2119	T2120	det	the,pathway
R1513	T2120	T2118	pobj	pathway,of
R1514	T2121	T2120	amod	endogenous,pathway
R1515	T2122	T2120	compound	PPARδ,pathway
R1516	T2123	T2097	punct	.,indicates
R1517	T2215	T2216	compound	Muscle,Fiber
R1518	T2216	T2217	compound	Fiber,Switch
R1519	T2217	T2218	nsubj	Switch,Protects
R152	T182	T183	amod	wild,type
R1520	T2219	T2217	prep	by,Switch
R1521	T2220	T2219	pobj	PPARδ,by
R1522	T2221	T2218	prep	Against,Protects
R1523	T2222	T2221	pobj	Obesity,Against
R1524	T2224	T2225	det	A,number
R1525	T2225	T2226	nsubj	number,shown
R1526	T2227	T2225	prep	of,number
R1527	T2228	T2229	amod	previous,studies
R1528	T2229	T2227	pobj	studies,of
R1529	T2230	T2226	aux	have,shown
R153	T183	T185	compound	type,mice
R1530	T2231	T2232	mark	that,have
R1531	T2232	T2226	ccomp	have,shown
R1532	T2233	T2234	amod	obese,individuals
R1533	T2234	T2232	nsubj	individuals,have
R1534	T2235	T2236	amod	fewer,fibers
R1535	T2236	T2232	dobj	fibers,have
R1536	T2237	T2236	amod	oxidative,fibers
R1537	T2238	T2232	punct	", ",have
R1538	T2239	T2232	advcl	implying,have
R1539	T2240	T2241	mark	that,play
R154	T184	T183	punct	-,type
R1540	T2241	T2239	ccomp	play,implying
R1541	T2242	T2243	det	the,presence
R1542	T2243	T2241	nsubj	presence,play
R1543	T2244	T2243	prep	of,presence
R1544	T2245	T2246	amod	oxidative,fibers
R1545	T2246	T2244	pobj	fibers,of
R1546	T2247	T2243	advmod	alone,presence
R1547	T2248	T2241	aux	may,play
R1548	T2249	T2250	det	a,part
R1549	T2250	T2241	dobj	part,play
R155	T185	T181	pobj	mice,of
R1550	T2251	T2241	prep	in,play
R1551	T2252	T2253	compound	obesity,resistance
R1552	T2253	T2251	pobj	resistance,in
R1553	T2254	T2226	punct	.,shown
R1554	T2256	T2257	aux	To,test
R1555	T2257	T2258	advcl	test,fed
R1556	T2259	T2260	det	this,possibility
R1557	T2260	T2257	dobj	possibility,test
R1558	T2261	T2258	punct	", ",fed
R1559	T2262	T2258	nsubj	we,fed
R156	T186	T179	prep	with,Treatment
R1560	T2263	T2264	det	the,mice
R1561	T2264	T2258	dobj	mice,fed
R1562	T2265	T2264	amod	transgenic,mice
R1563	T2266	T2264	cc	and,mice
R1564	T2267	T2268	poss	their,littermates
R1565	T2268	T2264	conj	littermates,mice
R1566	T2269	T2270	amod	wild,type
R1567	T2270	T2268	compound	type,littermates
R1568	T2271	T2270	punct	-,type
R1569	T2272	T2258	prep	with,fed
R157	T187	T188	compound	PPARδ,agonist
R1570	T2273	T2274	det	a,diet
R1571	T2274	T2272	pobj	diet,with
R1572	T2275	T2276	amod	high,fat
R1573	T2276	T2274	compound	fat,diet
R1574	T2277	T2276	punct	-,fat
R1575	T2278	T2258	prep	for,fed
R1576	T2279	T2280	nummod	97,d
R1577	T2280	T2278	pobj	d,for
R1578	T2281	T2258	punct	.,fed
R1579	T2283	T2284	mark	Although,were
R158	T188	T186	pobj	agonist,with
R1580	T2284	T2293	advcl	were,gained
R1581	T2285	T2286	det	the,weights
R1582	T2286	T2284	nsubj	weights,were
R1583	T2287	T2286	amod	initial,weights
R1584	T2288	T2286	compound	body,weights
R1585	T2289	T2286	prep	of,weights
R1586	T2290	T2291	det	the,groups
R1587	T2291	T2289	pobj	groups,of
R1588	T2292	T2291	nummod	two,groups
R1589	T2294	T2295	advmod	very,similar
R159	T189	T190	det	a,profile
R1590	T2295	T2284	acomp	similar,were
R1591	T2296	T2293	punct	", ",gained
R1592	T2297	T2298	det	the,mice
R1593	T2298	T2293	nsubj	mice,gained
R1594	T2299	T2298	amod	transgenic,mice
R1595	T2300	T2293	aux	had,gained
R1596	T2301	T2302	amod	less,50
R1597	T2302	T2304	nummod	50,%
R1598	T2303	T2302	quantmod	than,50
R1599	T2304	T2293	dobj	%,gained
R16	T129	T128	quantmod	to,twice
R160	T190	T180	dobj	profile,elicits
R1600	T2305	T2293	prep	at,gained
R1601	T2306	T2305	pobj	day,at
R1602	T2307	T2306	nummod	47,day
R1603	T2308	T2293	punct	", ",gained
R1604	T2309	T2293	cc	and,gained
R1605	T2310	T2311	advmod	only,third
R1606	T2311	T2293	conj	third,gained
R1607	T2312	T2311	advmod	one,third
R1608	T2313	T2311	punct	-,third
R1609	T2314	T2311	prep	at,third
R161	T191	T190	amod	similar,profile
R1610	T2315	T2314	pobj	day,at
R1611	T2316	T2315	nummod	97,day
R1612	T2317	T2311	punct	", ",third
R1613	T2318	T2311	conj	of,third
R1614	T2319	T2320	det	the,weight
R1615	T2320	T2318	pobj	weight,of
R1616	T2321	T2320	acl	gained,weight
R1617	T2322	T2321	agent	by,gained
R1618	T2323	T2324	det	the,animals
R1619	T2324	T2322	pobj	animals,by
R162	T239	T240	compound	running,capacity
R1620	T2325	T2326	amod	wild,type
R1621	T2326	T2324	compound	type,animals
R1622	T2327	T2326	punct	-,type
R1623	T2328	T2329	punct	(,Figure
R1624	T2329	T2318	parataxis	Figure,of
R1625	T2330	T2329	nummod	4A,Figure
R1626	T2331	T2329	punct	),Figure
R1627	T2332	T2293	punct	.,gained
R1628	T2334	T2335	det	The,mice
R1629	T2335	T2337	nsubj	mice,displayed
R163	T240	T236	conj	capacity,endurance
R1630	T2336	T2335	amod	transgenic,mice
R1631	T2338	T2339	advmod	significantly,higher
R1632	T2339	T2340	amod	higher,consumption
R1633	T2340	T2337	dobj	consumption,displayed
R1634	T2341	T2340	compound	oxygen,consumption
R1635	T2342	T2340	prep	on,consumption
R1636	T2343	T2344	det	the,diet
R1637	T2344	T2342	pobj	diet,on
R1638	T2345	T2346	amod	high,fat
R1639	T2346	T2344	compound	fat,diet
R164	T241	T228	aux	can,analyzed
R1640	T2347	T2346	punct	-,fat
R1641	T2348	T2340	prep	than,consumption
R1642	T2349	T2350	det	the,littermates
R1643	T2350	T2348	pobj	littermates,than
R1644	T2351	T2350	compound	control,littermates
R1645	T2352	T2353	punct	(,data
R1646	T2353	T2337	parataxis	data,displayed
R1647	T2354	T2353	amod	unpublished,data
R1648	T2355	T2353	punct	),data
R1649	T2356	T2337	punct	.,displayed
R165	T242	T228	auxpass	be,analyzed
R1650	T2358	T2359	prep	By,became
R1651	T2360	T2361	det	the,end
R1652	T2361	T2358	pobj	end,By
R1653	T2362	T2361	prep	of,end
R1654	T2363	T2364	det	this,experiment
R1655	T2364	T2362	pobj	experiment,of
R1656	T2365	T2359	punct	", ",became
R1657	T2366	T2367	det	the,littermates
R1658	T2367	T2359	nsubj	littermates,became
R1659	T2368	T2367	compound	control,littermates
R166	T243	T228	advmod	molecularly,analyzed
R1660	T2369	T2359	attr	obese,became
R1661	T2370	T2359	punct	", ",became
R1662	T2371	T2372	mark	whereas,maintained
R1663	T2372	T2359	advcl	maintained,became
R1664	T2373	T2374	det	the,mice
R1665	T2374	T2372	nsubj	mice,maintained
R1666	T2375	T2374	amod	transgenic,mice
R1667	T2376	T2372	advmod	still,maintained
R1668	T2377	T2378	det	a,weight
R1669	T2378	T2372	dobj	weight,maintained
R167	T244	T228	cc	and,analyzed
R1670	T2379	T2378	amod	normal,weight
R1671	T2380	T2378	compound	body,weight
R1672	T2381	T2378	cc	and,weight
R1673	T2382	T2383	compound	fat,mass
R1674	T2383	T2384	compound	mass,composition
R1675	T2384	T2378	conj	composition,weight
R1676	T2385	T2386	punct	(,Figure
R1677	T2386	T2372	parataxis	Figure,maintained
R1678	T2387	T2386	nummod	4A,Figure
R1679	T2388	T2386	punct	),Figure
R168	T245	T228	conj	manipulated,analyzed
R1680	T2389	T2359	punct	.,became
R1681	T2391	T2392	det	A,analysis
R1682	T2392	T2394	nsubj	analysis,revealed
R1683	T2393	T2392	amod	histological,analysis
R1684	T2395	T2392	prep	of,analysis
R1685	T2396	T2397	amod	inguinal,pad
R1686	T2397	T2395	pobj	pad,of
R1687	T2398	T2397	compound	fat,pad
R1688	T2399	T2400	det	a,size
R1689	T2400	T2394	dobj	size,revealed
R169	T246	T226	punct	.,demonstrate
R1690	T2401	T2402	advmod	much,smaller
R1691	T2402	T2400	amod	smaller,size
R1692	T2403	T2400	compound	cell,size
R1693	T2404	T2394	prep	in,revealed
R1694	T2405	T2406	det	the,mice
R1695	T2406	T2404	pobj	mice,in
R1696	T2407	T2406	amod	transgenic,mice
R1697	T2408	T2409	punct	(,Figure
R1698	T2409	T2394	parataxis	Figure,revealed
R1699	T2410	T2409	nummod	4B,Figure
R17	T130	T126	pobj	distance,of
R1700	T2411	T2409	punct	),Figure
R1701	T2412	T2394	punct	", ",revealed
R1702	T2413	T2394	prep	due,revealed
R1703	T2414	T2413	pcomp	to,due
R1704	T2415	T2416	det	the,capacity
R1705	T2416	T2413	pobj	capacity,due
R1706	T2417	T2416	amod	increased,capacity
R1707	T2418	T2416	nmod	muscle,capacity
R1708	T2419	T2416	amod	oxidative,capacity
R1709	T2420	T2394	punct	.,revealed
R1710	T2422	T2423	mark	While,was
R1711	T2423	T2425	advcl	was,was
R1712	T2424	T2423	expl	there,was
R1713	T2426	T2427	det	no,difference
R1714	T2427	T2423	attr	difference,was
R1715	T2428	T2427	amod	significant,difference
R1716	T2429	T2427	prep	in,difference
R1717	T2430	T2431	amod	intramuscular,content
R1718	T2431	T2429	pobj	content,in
R1719	T2432	T2431	compound	glycogen,content
R1720	T2433	T2425	punct	", ",was
R1721	T2434	T2435	det	the,content
R1722	T2435	T2425	nsubj	content,was
R1723	T2436	T2435	compound	triglyceride,content
R1724	T2437	T2438	advmod	much,less
R1725	T2438	T2425	acomp	less,was
R1726	T2439	T2425	prep	in,was
R1727	T2440	T2441	det	the,mice
R1728	T2441	T2439	pobj	mice,in
R1729	T2442	T2441	amod	transgenic,mice
R1730	T2443	T2444	punct	(,Figure
R1731	T2444	T2425	parataxis	Figure,was
R1732	T2445	T2444	nummod	4C,Figure
R1733	T2446	T2444	cc	and,Figure
R1734	T2447	T2444	conj	4D,Figure
R1735	T2448	T2444	punct	),Figure
R1736	T2449	T2425	punct	", ",was
R1737	T2450	T2451	dep	which,explain
R1738	T2451	T2425	advcl	explain,was
R1739	T2452	T2451	aux	may,explain
R1740	T2453	T2454	poss	their,tolerance
R1741	T2454	T2451	dobj	tolerance,explain
R1742	T2455	T2454	amod	improved,tolerance
R1743	T2456	T2454	compound	glucose,tolerance
R1744	T2457	T2458	punct	(,Figure
R1745	T2458	T2451	parataxis	Figure,explain
R1746	T2459	T2458	nummod	4E,Figure
R1747	T2460	T2458	punct	),Figure
R1748	T2461	T2425	punct	.,was
R1749	T2463	T2464	nsubj	We,placed
R1750	T2465	T2464	advmod	also,placed
R1751	T2466	T2467	amod	wild,type
R1752	T2467	T2469	compound	type,mice
R1753	T2468	T2467	punct	-,type
R1754	T2469	T2464	dobj	mice,placed
R1755	T2470	T2469	compound	C57BJ6,mice
R1756	T2471	T2464	prep	on,placed
R1757	T2472	T2473	det	the,diet
R1758	T2473	T2471	pobj	diet,on
R1759	T2474	T2475	amod	high,fat
R1760	T2475	T2473	compound	fat,diet
R1761	T2476	T2475	punct	-,fat
R1762	T2477	T2464	cc	and,placed
R1763	T2478	T2464	conj	treated,placed
R1764	T2479	T2478	dobj	them,treated
R1765	T2480	T2478	prep	with,treated
R1766	T2481	T2482	preconj	either,vehicle
R1767	T2482	T2480	pobj	vehicle,with
R1768	T2483	T2482	cc	or,vehicle
R1769	T2484	T2485	det	the,GW501516
R1770	T2485	T2482	conj	GW501516,vehicle
R1771	T2486	T2487	compound	PPARδ,agonist
R1772	T2487	T2485	compound	agonist,GW501516
R1773	T2488	T2478	prep	for,treated
R1774	T2489	T2490	nummod	2,mo
R1775	T2490	T2488	pobj	mo,for
R1776	T2491	T2464	punct	.,placed
R1777	T2493	T2494	nsubj	GW501516,produced
R1778	T2494	T2495	ccomp	produced,resulted
R1779	T2496	T2497	det	a,induction
R1780	T2497	T2494	dobj	induction,produced
R1781	T2498	T2497	amod	sustained,induction
R1782	T2499	T2497	prep	of,induction
R1783	T2500	T2499	pobj	genes,of
R1784	T2501	T2500	prep	for,genes
R1785	T2502	T2503	nmod	type,fibers
R1786	T2503	T2501	pobj	fibers,for
R1787	T2504	T2502	nummod	I,type
R1788	T2505	T2503	compound	muscle,fibers
R1789	T2506	T2495	punct	;,resulted
R1790	T2507	T2495	nsubj	this,resulted
R1791	T2508	T2495	punct	", ",resulted
R1792	T2509	T2510	advmod	at,least
R1793	T2510	T2511	advmod	least,in
R1794	T2511	T2495	prep	in,resulted
R1795	T2512	T2511	amod	part,in
R1796	T2513	T2495	punct	", ",resulted
R1797	T2514	T2495	prep	in,resulted
R1798	T2515	T2516	det	an,gain
R1799	T2516	T2514	pobj	gain,in
R18	T131	T130	det	the,distance
R1800	T2517	T2518	advmod	only,30
R1801	T2518	T2519	nummod	30,%
R1802	T2519	T2516	compound	%,gain
R1803	T2520	T2516	prep	in,gain
R1804	T2521	T2522	compound	body,weight
R1805	T2522	T2520	pobj	weight,in
R1806	T2523	T2516	punct	", ",gain
R1807	T2524	T2525	det	a,accumulation
R1808	T2525	T2516	conj	accumulation,gain
R1809	T2526	T2527	advmod	dramatically,reduced
R1810	T2527	T2525	amod	reduced,accumulation
R1811	T2528	T2529	compound	fat,mass
R1812	T2529	T2525	compound	mass,accumulation
R1813	T2530	T2525	punct	", ",accumulation
R1814	T2531	T2525	cc	and,accumulation
R1815	T2532	T2533	amod	improved,tolerance
R1816	T2533	T2525	conj	tolerance,accumulation
R1817	T2534	T2533	compound	glucose,tolerance
R1818	T2535	T2516	punct	", ",gain
R1819	T2536	T2516	prep	compared,gain
R1820	T2537	T2536	prep	to,compared
R1821	T2538	T2539	det	the,group
R1822	T2539	T2537	pobj	group,to
R1823	T2540	T2541	npadvmod	vehicle,treated
R1824	T2541	T2539	amod	treated,group
R1825	T2542	T2541	punct	-,treated
R1826	T2543	T2544	punct	(,Figure
R1827	T2544	T2495	parataxis	Figure,resulted
R1828	T2545	T2544	nummod	5,Figure
R1829	T2546	T2544	punct	),Figure
R1830	T2547	T2495	punct	.,resulted
R1831	T2549	T2550	advmod	Thus,has
R1832	T2551	T2550	punct	", ",has
R1833	T2552	T2553	compound	muscle,fiber
R1834	T2553	T2554	compound	fiber,conversion
R1835	T2554	T2550	nsubj	conversion,has
R1836	T2555	T2554	prep	by,conversion
R1837	T2556	T2555	pobj	stimulation,by
R1838	T2557	T2556	prep	with,stimulation
R1839	T2558	T2559	det	the,agonist
R1840	T2559	T2557	pobj	agonist,with
R1841	T2560	T2559	compound	PPARδ,agonist
R1842	T2561	T2559	cc	or,agonist
R1843	T2562	T2563	det	the,transgene
R1844	T2563	T2559	conj	transgene,agonist
R1845	T2564	T2563	amod	activated,transgene
R1846	T2565	T2566	det	a,role
R1847	T2566	T2550	dobj	role,has
R1848	T2567	T2566	amod	protective,role
R1849	T2568	T2566	prep	against,role
R1850	T2569	T2568	pobj	obesity,against
R1851	T2570	T2550	punct	.,has
R1852	T2626	T2627	nsubj	Activation,Enhances
R1853	T2628	T2626	prep	of,Activation
R1854	T2629	T2628	pobj	PPARδ,of
R1855	T2630	T2631	amod	Physical,Performance
R1856	T2631	T2627	dobj	Performance,Enhances
R1857	T2633	T2634	nmod	Muscle,capacity
R1858	T2634	T2636	nsubj	capacity,is
R1859	T2635	T2634	amod	oxidative,capacity
R1860	T2637	T2638	det	a,factor
R1861	T2638	T2636	attr	factor,is
R1862	T2639	T2638	amod	crucial,factor
R1863	T2640	T2638	prep	for,factor
R1864	T2641	T2640	pcomp	determining,for
R1865	T2642	T2641	dobj	endurance,determining
R1866	T2643	T2642	cc	and,endurance
R1867	T2644	T2642	conj	fatigue,endurance
R1868	T2645	T2636	punct	.,is
R1869	T2647	T2648	advmod	Indeed,considered
R1870	T2649	T2648	punct	", ",considered
R1871	T2650	T2651	nmod	type,fibers
R1872	T2651	T2648	nsubjpass	fibers,considered
R1873	T2652	T2650	nummod	I,type
R1874	T2653	T2654	advmod	adaptively,generated
R1875	T2654	T2651	acl	generated,fibers
R1876	T2655	T2654	prep	through,generated
R1877	T2656	T2657	compound	exercise,training
R1878	T2657	T2655	pobj	training,through
R1879	T2658	T2648	auxpass	are,considered
R1880	T2659	T2660	aux	to,be
R1881	T2660	T2648	xcomp	be,considered
R1882	T2661	T2662	npadvmod	fatigue,resistant
R1883	T2662	T2660	acomp	resistant,be
R1884	T2663	T2648	punct	.,considered
R1885	T2665	T2666	advmod	However,is
R1886	T2667	T2666	punct	", ",is
R1887	T2668	T2669	mark	whether,contribute
R1888	T2669	T2666	csubj	contribute,is
R1889	T2670	T2671	det	the,fibers
R1890	T2671	T2669	nsubj	fibers,contribute
R1891	T2672	T2671	nmod	type,fibers
R1892	T2673	T2672	nummod	I,type
R1893	T2674	T2671	acl	generated,fibers
R1894	T2675	T2674	advmod	molecularly,generated
R1895	T2676	T2674	prep	via,generated
R1896	T2677	T2678	compound	PPARδ,expression
R1897	T2678	T2676	pobj	expression,via
R1898	T2679	T2669	aux	can,contribute
R1899	T2680	T2669	prep	to,contribute
R19	T132	T130	prep	of,distance
R190	T425	T426	amod	Skeletal,fibers
R1900	T2681	T2682	amod	enhanced,performance
R1901	T2682	T2680	pobj	performance,to
R1902	T2683	T2669	prep	in,contribute
R1903	T2684	T2685	det	the,absence
R1904	T2685	T2683	pobj	absence,in
R1905	T2686	T2685	prep	of,absence
R1906	T2687	T2688	amod	previous,training
R1907	T2688	T2686	pobj	training,of
R1908	T2689	T2666	acomp	unclear,is
R1909	T2690	T2666	punct	.,is
R191	T426	T428	nsubjpass	fibers,classified
R1910	T2692	T2693	prep	In,evaluated
R1911	T2694	T2692	pobj	fact,In
R1912	T2695	T2693	punct	", ",evaluated
R1913	T2696	T2697	det	the,consequence
R1914	T2697	T2693	nsubjpass	consequence,evaluated
R1915	T2698	T2697	prep	of,consequence
R1916	T2699	T2700	advmod	genetically,induced
R1917	T2700	T2701	amod	induced,switch
R1918	T2701	T2698	pobj	switch,of
R1919	T2702	T2701	compound	fiber,switch
R192	T427	T426	compound	muscle,fibers
R1920	T2703	T2697	prep	on,consequence
R1921	T2704	T2705	amod	running,capacity
R1922	T2705	T2703	pobj	capacity,on
R1923	T2706	T2693	aux	has,evaluated
R1924	T2707	T2693	prep	to,evaluated
R1925	T2708	T2709	poss	our,knowledge
R1926	T2709	T2707	pobj	knowledge,to
R1927	T2710	T2693	neg	never,evaluated
R1928	T2711	T2693	auxpass	been,evaluated
R1929	T2712	T2693	punct	.,evaluated
R193	T429	T428	auxpass	are,classified
R1930	T2714	T2715	nsubj	We,compared
R1931	T2716	T2715	advmod	thus,compared
R1932	T2717	T2718	compound	exercise,performance
R1933	T2718	T2715	dobj	performance,compared
R1934	T2719	T2715	prep	between,compared
R1935	T2720	T2721	amod	untrained,littermates
R1936	T2721	T2719	pobj	littermates,between
R1937	T2722	T2721	punct	", ",littermates
R1938	T2723	T2724	compound	body,weight
R1939	T2724	T2726	npadvmod	weight,matched
R194	T430	T428	advmod	generally,classified
R1940	T2725	T2724	punct	-,weight
R1941	T2726	T2721	amod	matched,littermates
R1942	T2727	T2726	punct	-,matched
R1943	T2728	T2721	amod	transgenic,littermates
R1944	T2729	T2728	cc	and,transgenic
R1945	T2730	T2731	amod	wild,type
R1946	T2731	T2728	conj	type,transgenic
R1947	T2732	T2731	punct	-,type
R1948	T2733	T2715	punct	.,compared
R1949	T2735	T2736	nsubjpass	Mice,run
R195	T431	T428	prep	as,classified
R1950	T2737	T2736	auxpass	were,run
R1951	T2738	T2736	prep	on,run
R1952	T2739	T2740	npadvmod	oxygen,infused
R1953	T2740	T2742	amod	infused,treadmills
R1954	T2741	T2740	punct	-,infused
R1955	T2742	T2738	pobj	treadmills,on
R1956	T2743	T2742	punct	", ",treadmills
R1957	T2744	T2742	amod	enclosed,treadmills
R1958	T2745	T2736	prep	until,run
R1959	T2746	T2745	pobj	exhaustion,until
R196	T432	T433	nmod	type,fibers
R1960	T2747	T2736	punct	.,run
R1961	T2749	T2750	advmod	Strikingly,increased
R1962	T2751	T2750	punct	", ",increased
R1963	T2752	T2753	det	the,time
R1964	T2753	T2750	nsubjpass	time,increased
R1965	T2754	T2753	compound	running,time
R1966	T2755	T2753	cc	and,time
R1967	T2756	T2753	conj	distance,time
R1968	T2757	T2758	det	the,mice
R1969	T2758	T2760	nsubj	mice,were
R197	T433	T431	pobj	fibers,as
R1970	T2759	T2758	amod	transgenic,mice
R1971	T2760	T2753	advcl	were,time
R1972	T2761	T2760	acomp	able,were
R1973	T2762	T2763	aux	to,sustain
R1974	T2763	T2761	xcomp	sustain,able
R1975	T2764	T2750	auxpass	were,increased
R1976	T2765	T2750	prep	by,increased
R1977	T2766	T2767	nummod	67,%
R1978	T2767	T2765	pobj	%,by
R1979	T2768	T2767	cc	and,%
R198	T434	T432	nummod	I,type
R1980	T2769	T2770	nummod	92,%
R1981	T2770	T2767	conj	%,%
R1982	T2771	T2750	punct	", ",increased
R1983	T2772	T2750	advmod	respectively,increased
R1984	T2773	T2774	punct	(,Figure
R1985	T2774	T2750	parataxis	Figure,increased
R1986	T2775	T2774	nummod	6A,Figure
R1987	T2776	T2774	punct	;,Figure
R1988	T2777	T2778	advmod	also,see
R1989	T2778	T2774	advcl	see,Figure
R199	T435	T436	punct	(,slow
R1990	T2779	T2780	compound	Videos,S1
R1991	T2780	T2778	dobj	S1,see
R1992	T2781	T2780	cc	and,S1
R1993	T2782	T2780	conj	S2,S1
R1994	T2783	T2774	punct	),Figure
R1995	T2784	T2750	punct	.,increased
R1996	T2786	T2787	det	The,mice
R1997	T2787	T2789	nsubj	mice,ran
R1998	T2788	T2787	amod	transgenic,mice
R1999	T2790	T2791	advmod	about,1
R2	T113	T100	punct	.,identified
R20	T133	T134	det	a,littermate
R200	T436	T432	parataxis	slow,type
R2000	T2791	T2792	nummod	1,h
R2001	T2792	T2793	npadvmod	h,longer
R2002	T2793	T2789	advmod	longer,ran
R2003	T2794	T2793	prep	than,longer
R2004	T2795	T2796	det	the,controls
R2005	T2796	T2794	pobj	controls,than
R2006	T2797	T2789	punct	", ",ran
R2007	T2798	T2799	dep	which,translates
R2008	T2799	T2789	advcl	translates,ran
R2009	T2800	T2799	prep	to,translates
R201	T437	T436	amod	oxidative,slow
R2010	T2801	T2802	advmod	nearly,a
R2011	T2802	T2803	nummod	a,kilometer
R2012	T2803	T2804	npadvmod	kilometer,further
R2013	T2804	T2800	pcomp	further,to
R2014	T2805	T2789	punct	.,ran
R2015	T2807	T2808	det	No,differences
R2016	T2808	T2810	nsubjpass	differences,observed
R2017	T2809	T2808	amod	significant,differences
R2018	T2811	T2808	prep	in,differences
R2019	T2812	T2813	compound	muscle,mass
R202	T438	T436	punct	/,slow
R2020	T2813	T2811	pobj	mass,in
R2021	T2814	T2815	punct	(,data
R2022	T2815	T2813	parataxis	data,mass
R2023	T2816	T2815	amod	unpublished,data
R2024	T2817	T2815	punct	),data
R2025	T2818	T2813	cc	and,mass
R2026	T2819	T2820	amod	daily,activity
R2027	T2820	T2813	conj	activity,mass
R2028	T2821	T2822	punct	(,209
R2029	T2822	T2820	parataxis	209,activity
R203	T439	T436	punct	),slow
R2030	T2823	T2824	amod	total,counts
R2031	T2824	T2822	dep	counts,209
R2032	T2825	T2824	prep	of,counts
R2033	T2826	T2825	pobj	activity,of
R2034	T2827	T2826	prep	per,activity
R2035	T2828	T2827	pobj	hour,per
R2036	T2829	T2822	punct	: ,209
R2037	T2830	T2822	quantmod	1618,209
R2038	T2831	T2822	punct	±,209
R2039	T2832	T2822	prep	for,209
R204	T440	T432	cc	or,type
R2040	T2833	T2832	amod	transgenic,for
R2041	T2834	T2822	cc	versus,209
R2042	T2835	T2836	quantmod	1987,301
R2043	T2836	T2822	conj	301,209
R2044	T2837	T2836	punct	±,301
R2045	T2838	T2836	prep	for,301
R2046	T2839	T2840	amod	wild,type
R2047	T2840	T2838	pobj	type,for
R2048	T2841	T2840	punct	-,type
R2049	T2842	T2822	punct	", ",209
R205	T441	T432	conj	type,type
R2050	T2843	T2844	nsubj	p,0.35
R2051	T2844	T2822	ccomp	0.35,209
R2052	T2845	T2844	punct	>,0.35
R2053	T2846	T2822	punct	", ",209
R2054	T2847	T2848	nsubj	n,4
R2055	T2848	T2822	ccomp	4,209
R2056	T2849	T2848	punct	=,4
R2057	T2850	T2822	punct	),209
R2058	T2851	T2810	auxpass	were,observed
R2059	T2852	T2810	prep	between,observed
R206	T442	T441	nummod	II,type
R2060	T2853	T2854	det	the,mice
R2061	T2854	T2852	pobj	mice,between
R2062	T2855	T2854	amod	transgenic,mice
R2063	T2856	T2855	cc	and,transgenic
R2064	T2857	T2855	conj	control,transgenic
R2065	T2858	T2810	punct	.,observed
R2066	T2860	T2861	advmod	Thus,is
R2067	T2862	T2861	punct	", ",is
R2068	T2863	T2864	det	the,increase
R2069	T2864	T2861	nsubj	increase,is
R207	T443	T444	punct	(,fast
R2070	T2865	T2864	amod	remarkable,increase
R2071	T2866	T2864	prep	in,increase
R2072	T2867	T2866	pobj	endurance,in
R2073	T2868	T2869	det	the,manifestation
R2074	T2869	T2861	attr	manifestation,is
R2075	T2870	T2869	amod	physiologic,manifestation
R2076	T2871	T2869	prep	of,manifestation
R2077	T2872	T2873	compound	muscle,fiber
R2078	T2873	T2874	compound	fiber,transformation
R2079	T2874	T2871	pobj	transformation,of
R208	T444	T441	parataxis	fast,type
R2080	T2875	T2861	punct	.,is
R2081	T2877	T2878	nsubj	This,suggests
R2082	T2879	T2880	mark	that,is
R2083	T2880	T2878	ccomp	is,suggests
R2084	T2881	T2882	advmod	genetically,directed
R2085	T2882	T2883	amod	directed,switch
R2086	T2883	T2880	nsubj	switch,is
R2087	T2884	T2885	compound	muscle,fiber
R2088	T2885	T2883	compound	fiber,switch
R2089	T2886	T2887	advmod	physiologically,relevant
R209	T445	T444	amod	glycolytic,fast
R2090	T2887	T2880	acomp	relevant,is
R2091	T2888	T2886	cc	and,physiologically
R2092	T2889	T2886	conj	functionally,physiologically
R2093	T2890	T2878	punct	.,suggests
R2094	T2892	T2893	prep	In,looked
R2095	T2894	T2892	pobj	addition,In
R2096	T2895	T2893	punct	", ",looked
R2097	T2896	T2893	nsubj	we,looked
R2098	T2897	T2893	prep	at,looked
R2099	T2898	T2899	det	what,effect
R21	T134	T132	pobj	littermate,of
R210	T446	T444	punct	/,fast
R2100	T2899	T2900	dep	effect,has
R2101	T2900	T2897	pcomp	has,at
R2102	T2901	T2902	det	the,absence
R2103	T2902	T2900	nsubj	absence,has
R2104	T2903	T2902	prep	of,absence
R2105	T2904	T2905	compound	PPARδ,function
R2106	T2905	T2903	pobj	function,of
R2107	T2906	T2900	prep	on,has
R2108	T2907	T2908	compound	exercise,endurance
R2109	T2908	T2906	pobj	endurance,on
R211	T447	T444	punct	),fast
R2110	T2909	T2893	punct	.,looked
R2111	T2911	T2912	prep	In,sustain
R2112	T2913	T2914	det	the,test
R2113	T2914	T2911	pobj	test,In
R2114	T2915	T2914	compound	treadmill,test
R2115	T2916	T2912	punct	", ",sustain
R2116	T2917	T2918	det	the,mice
R2117	T2918	T2912	nsubj	mice,sustain
R2118	T2919	T2920	npadvmod	PPARδ,null
R2119	T2920	T2918	amod	null,mice
R212	T448	T428	punct	.,classified
R2120	T2921	T2920	punct	-,null
R2121	T2922	T2912	aux	could,sustain
R2122	T2923	T2924	advmod	only,%
R2123	T2924	T2912	dobj	%,sustain
R2124	T2925	T2924	nummod	38,%
R2125	T2926	T2924	prep	of,%
R2126	T2927	T2928	det	the,time
R2127	T2928	T2926	pobj	time,of
R2128	T2929	T2928	compound	running,time
R2129	T2930	T2924	cc	and,%
R213	T450	T451	nsubj	They,display
R2130	T2931	T2932	nummod	34,%
R2131	T2932	T2924	conj	%,%
R2132	T2933	T2932	prep	of,%
R2133	T2934	T2935	det	the,distance
R2134	T2935	T2933	pobj	distance,of
R2135	T2936	T2932	prep	of,%
R2136	T2937	T2938	poss	their,counterparts
R2137	T2938	T2936	pobj	counterparts,of
R2138	T2939	T2940	npadvmod	age,matched
R2139	T2940	T2938	amod	matched,counterparts
R214	T452	T453	amod	marked,differences
R2140	T2941	T2939	punct	-,age
R2141	T2942	T2939	cc	and,age
R2142	T2943	T2939	conj	weight,age
R2143	T2944	T2940	punct	-,matched
R2144	T2945	T2946	amod	wild,type
R2145	T2946	T2938	compound	type,counterparts
R2146	T2947	T2946	punct	-,type
R2147	T2948	T2949	punct	(,Figure
R2148	T2949	T2912	parataxis	Figure,sustain
R2149	T2950	T2949	nummod	6B,Figure
R215	T453	T451	dobj	differences,display
R2150	T2951	T2949	punct	),Figure
R2151	T2952	T2912	punct	.,sustain
R2152	T2954	T2955	det	These,results
R2153	T2955	T2956	nsubj	results,support
R2154	T2957	T2956	advmod	further,support
R2155	T2958	T2959	det	a,role
R2156	T2959	T2956	dobj	role,support
R2157	T2960	T2959	prep	for,role
R2158	T2961	T2960	pobj	PPARδ,for
R2159	T2962	T2959	prep	in,role
R216	T454	T451	prep	in,display
R2160	T2963	T2962	pobj	enhancement,in
R2161	T2964	T2963	prep	of,enhancement
R2162	T2965	T2966	amod	physical,performance
R2163	T2966	T2964	pobj	performance,of
R2164	T2967	T2956	punct	.,support
R2169	T3182	T3183	poss	Our,data
R217	T455	T454	pobj	respect,in
R2170	T3183	T3184	nsubj	data,reveal
R2171	T3185	T3186	mark	that,regulate
R2172	T3186	T3184	ccomp	regulate,reveal
R2173	T3187	T3188	det	a,pathway
R2174	T3188	T3186	nsubj	pathway,regulate
R2175	T3189	T3190	npadvmod	PPARδ,mediated
R2176	T3190	T3188	amod	mediated,pathway
R2177	T3191	T3190	punct	-,mediated
R2178	T3192	T3188	amod	transcriptional,pathway
R2179	T3193	T3186	aux	can,regulate
R218	T456	T455	prep	to,respect
R2180	T3194	T3195	compound	muscle,fiber
R2181	T3195	T3196	compound	fiber,specification
R2182	T3196	T3186	dobj	specification,regulate
R2183	T3197	T3186	punct	", ",regulate
R2184	T3198	T3186	advcl	enabling,regulate
R2185	T3199	T3200	det	the,generation
R2186	T3200	T3198	dobj	generation,enabling
R2187	T3201	T3200	prep	of,generation
R2188	T3202	T3203	det	a,strain
R2189	T3203	T3201	pobj	strain,of
R219	T457	T456	pobj	contraction,to
R2190	T3204	T3203	prep	of,strain
R2191	T3205	T3204	pobj	mice,of
R2192	T3206	T3203	prep	with,strain
R2193	T3207	T3208	det	a,phenotype
R2194	T3208	T3206	pobj	phenotype,with
R2195	T3209	T3208	punct	“,phenotype
R2196	T3210	T3211	amod	long,distance
R2197	T3211	T3213	nmod	distance,running
R2198	T3212	T3211	punct	-,distance
R2199	T3213	T3208	nmod	running,phenotype
R22	T135	T136	amod	wild,type
R220	T458	T457	punct	", ",contraction
R2200	T3214	T3208	punct	”,phenotype
R2201	T3215	T3184	punct	.,reveal
R2202	T3217	T3218	nsubj	We,show
R2203	T3219	T3220	mark	that,produces
R2204	T3220	T3218	ccomp	produces,show
R2205	T3221	T3222	amod	targeted,expression
R2206	T3222	T3220	nsubj	expression,produces
R2207	T3223	T3222	prep	of,expression
R2208	T3224	T3225	det	an,form
R2209	T3225	T3223	pobj	form,of
R221	T459	T457	conj	metabolism,contraction
R2210	T3226	T3225	amod	activated,form
R2211	T3227	T3225	prep	of,form
R2212	T3228	T3227	pobj	PPARδ,of
R2213	T3229	T3230	amod	profound,increases
R2214	T3230	T3220	dobj	increases,produces
R2215	T3231	T3229	cc	and,profound
R2216	T3232	T3229	conj	coordinated,profound
R2217	T3233	T3230	prep	in,increases
R2218	T3234	T3235	compound	oxidation,enzymes
R2219	T3235	T3233	pobj	enzymes,in
R222	T460	T459	punct	", ",metabolism
R2220	T3236	T3235	punct	", ",enzymes
R2221	T3237	T3238	amod	mitochondrial,biogenesis
R2222	T3238	T3235	conj	biogenesis,enzymes
R2223	T3239	T3238	punct	", ",biogenesis
R2224	T3240	T3238	cc	and,biogenesis
R2225	T3241	T3238	conj	production,biogenesis
R2226	T3242	T3241	prep	of,production
R2227	T3243	T3244	amod	specialized,proteins
R2228	T3244	T3242	pobj	proteins,of
R2229	T3245	T3246	nmod	type,fiber
R223	T461	T459	cc	and,metabolism
R2230	T3246	T3244	nmod	fiber,proteins
R2231	T3247	T3245	nummod	I,type
R2232	T3248	T3244	amod	contractile,proteins
R2233	T3249	T3235	punct	—,enzymes
R2234	T3250	T3251	det	the,hallmarks
R2235	T3251	T3235	appos	hallmarks,enzymes
R2236	T3252	T3251	nummod	three,hallmarks
R2237	T3253	T3251	prep	for,hallmarks
R2238	T3254	T3255	compound	muscle,fiber
R2239	T3255	T3256	compound	fiber,switching
R224	T462	T459	conj	susceptibility,metabolism
R2240	T3256	T3253	pobj	switching,for
R2241	T3257	T3256	compound	type,switching
R2242	T3258	T3259	punct	(,Figure
R2243	T3259	T3220	parataxis	Figure,produces
R2244	T3260	T3259	nummod	6C,Figure
R2245	T3261	T3259	punct	),Figure
R2246	T3262	T3218	punct	.,show
R2247	T3264	T3265	mark	While,seen
R2248	T3265	T3275	advcl	seen,are
R2249	T3266	T3265	nsubjpass	induction,seen
R225	T463	T462	prep	to,susceptibility
R2250	T3267	T3266	prep	of,induction
R2251	T3268	T3269	compound	muscle,enzymes
R2252	T3269	T3267	pobj	enzymes,of
R2253	T3270	T3269	compound	oxidation,enzymes
R2254	T3271	T3266	prep	by,induction
R2255	T3272	T3271	pobj	PPARδ,by
R2256	T3273	T3265	aux	has,seen
R2257	T3274	T3265	auxpass	been,seen
R2258	T3276	T3277	preconj	both,vivo
R2259	T3277	T3265	advmod	vivo,seen
R226	T464	T463	pobj	fatigue,to
R2260	T3278	T3277	advmod	in,vivo
R2261	T3279	T3277	cc	and,vivo
R2262	T3280	T3281	advmod	in,vitro
R2263	T3281	T3277	conj	vitro,vivo
R2264	T3282	T3283	punct	(,Muoio
R2265	T3283	T3265	meta	Muoio,seen
R2266	T3284	T3283	nmod	et,Muoio
R2267	T3285	T3283	nmod	al.,Muoio
R2268	T3286	T3283	nummod	2002,Muoio
R2269	T3287	T3283	punct	;,Muoio
R227	T465	T451	punct	.,display
R2270	T3288	T3283	nmod	Dressel,Muoio
R2271	T3289	T3283	nmod	et,Muoio
R2272	T3290	T3283	nmod	al.,Muoio
R2273	T3291	T3283	nummod	2003,Muoio
R2274	T3292	T3283	punct	;,Muoio
R2275	T3293	T3283	nmod	Luquet,Muoio
R2276	T3294	T3283	nmod	et,Muoio
R2277	T3295	T3283	nmod	al.,Muoio
R2278	T3296	T3283	nummod	2003,Muoio
R2279	T3297	T3283	punct	;,Muoio
R228	T467	T468	nmod	Type,fibers
R2280	T3298	T3283	nmod	Tanaka,Muoio
R2281	T3299	T3283	nmod	et,Muoio
R2282	T3300	T3283	nmod	al.,Muoio
R2283	T3301	T3283	nummod	2003,Muoio
R2284	T3302	T3283	punct	;,Muoio
R2285	T3303	T3283	nmod	Wang,Muoio
R2286	T3304	T3283	nmod	et,Muoio
R2287	T3305	T3283	nmod	al.,Muoio
R2288	T3306	T3283	nummod	2003,Muoio
R2289	T3307	T3283	punct	),Muoio
R229	T468	T470	nsubj	fibers,are
R2290	T3308	T3275	punct	", ",are
R2291	T3309	T3310	poss	its,effects
R2292	T3310	T3275	nsubj	effects,are
R2293	T3311	T3310	acl	shown,effects
R2294	T3312	T3311	advmod	here,shown
R2295	T3313	T3311	prep	on,shown
R2296	T3314	T3315	compound	muscle,fiber
R2297	T3315	T3316	compound	fiber,switching
R2298	T3316	T3313	pobj	switching,on
R2299	T3317	T3275	acomp	unexpected,are
R23	T136	T134	compound	type,littermate
R230	T469	T467	nummod	I,Type
R2300	T3318	T3275	punct	.,are
R2301	T3320	T3321	det	These,changes
R2302	T3321	T3323	nsubj	changes,lead
R2303	T3322	T3321	amod	progressive,changes
R2304	T3324	T3321	prep	in,changes
R2305	T3325	T3326	amod	oxidative,capacity
R2306	T3326	T3324	pobj	capacity,in
R2307	T3327	T3321	prep	in,changes
R2308	T3328	T3327	pobj	conjunction,in
R2309	T3329	T3328	prep	with,conjunction
R231	T471	T472	npadvmod	mitochondria,rich
R2310	T3330	T3331	amod	eventual,changes
R2311	T3331	T3329	pobj	changes,with
R2312	T3332	T3331	prep	in,changes
R2313	T3333	T3334	nmod	type,fiber
R2314	T3334	T3332	pobj	fiber,in
R2315	T3335	T3333	nummod	I,type
R2316	T3336	T3334	compound	muscle,fiber
R2317	T3337	T3323	prep	to,lead
R2318	T3338	T3339	det	a,profile
R2319	T3339	T3337	pobj	profile,to
R232	T472	T470	acomp	rich,are
R2320	T3340	T3341	advmod	dramatically,improved
R2321	T3341	T3339	amod	improved,profile
R2322	T3342	T3339	compound	exercise,profile
R2323	T3343	T3339	cc	and,profile
R2324	T3344	T3339	conj	protection,profile
R2325	T3345	T3344	prep	against,protection
R2326	T3346	T3345	pobj	obesity,against
R2327	T3347	T3323	punct	.,lead
R2328	T3349	T3350	nsubj	This,depend
R2329	T3351	T3350	aux	does,depend
R233	T473	T472	punct	-,rich
R2330	T3352	T3350	neg	not,depend
R2331	T3353	T3350	advmod	solely,depend
R2332	T3354	T3350	prep	on,depend
R2333	T3355	T3354	pcomp	achieving,on
R2334	T3356	T3357	det	a,switch
R2335	T3357	T3355	dobj	switch,achieving
R2336	T3358	T3357	amod	directed,switch
R2337	T3359	T3360	compound	muscle,fiber
R2338	T3360	T3357	compound	fiber,switch
R2339	T3361	T3357	compound	type,switch
R234	T474	T470	cc	and,are
R2340	T3362	T3350	cc	but,depend
R2341	T3363	T3364	advmod	also,requires
R2342	T3364	T3350	conj	requires,depend
R2343	T3365	T3366	predet	all,changes
R2344	T3366	T3364	dobj	changes,requires
R2345	T3367	T3366	det	the,changes
R2346	T3368	T3366	amod	associated,changes
R2347	T3369	T3366	prep	in,changes
R2348	T3370	T3371	amod	neural,innervation
R2349	T3371	T3369	pobj	innervation,in
R235	T475	T476	advmod	mainly,use
R2350	T3372	T3371	punct	", ",innervation
R2351	T3373	T3374	compound	motor,neuron
R2352	T3374	T3375	compound	neuron,function
R2353	T3375	T3371	conj	function,innervation
R2354	T3376	T3375	punct	", ",function
R2355	T3377	T3375	cc	and,function
R2356	T3378	T3379	amod	peripheral,adaptation
R2357	T3379	T3375	conj	adaptation,function
R2358	T3380	T3379	amod	metabolic,adaptation
R2359	T3381	T3382	aux	to,enable
R236	T476	T470	conj	use,are
R2360	T3382	T3364	advcl	enable,requires
R2361	T3383	T3384	det	a,response
R2362	T3384	T3382	dobj	response,enable
R2363	T3385	T3384	amod	new,response
R2364	T3386	T3384	amod	integrated,response
R2365	T3387	T3384	amod	physiological,response
R2366	T3388	T3350	punct	.,depend
R2367	T3390	T3391	advmod	Accordingly,recapitulates
R2368	T3392	T3391	punct	", ",recapitulates
R2369	T3393	T3391	nsubj	activation,recapitulates
R237	T477	T478	amod	oxidative,metabolism
R2370	T3394	T3393	prep	of,activation
R2371	T3395	T3396	compound	muscle,PPARδ
R2372	T3396	T3394	pobj	PPARδ,of
R2373	T3397	T3391	advmod	essentially,recapitulates
R2374	T3398	T3399	det	the,effects
R2375	T3399	T3391	dobj	effects,recapitulates
R2376	T3400	T3399	prep	of,effects
R2377	T3401	T3402	compound	exercise,training
R2378	T3402	T3400	pobj	training,of
R2379	T3403	T3404	advmod	even,in
R238	T478	T476	dobj	metabolism,use
R2380	T3404	T3391	prep	in,recapitulates
R2381	T3405	T3406	det	the,absence
R2382	T3406	T3404	pobj	absence,in
R2383	T3407	T3406	prep	of,absence
R2384	T3408	T3407	pobj	training,of
R2385	T3409	T3408	appos	itself,training
R2386	T3410	T3391	punct	.,recapitulates
R2387	T3412	T3413	prep	To,described
R2388	T3414	T3415	poss	our,knowledge
R2389	T3415	T3412	pobj	knowledge,To
R239	T479	T476	prep	for,use
R2390	T3416	T3413	punct	", ",described
R2391	T3417	T3413	nsubjpass	this,described
R2392	T3418	T3413	aux	has,described
R2393	T3419	T3413	neg	not,described
R2394	T3420	T3413	auxpass	been,described
R2395	T3421	T3413	advmod	directly,described
R2396	T3422	T3413	prep	for,described
R2397	T3423	T3424	det	any,factor
R2398	T3424	T3422	pobj	factor,for
R2399	T3425	T3424	amod	other,factor
R24	T137	T136	punct	-,type
R240	T480	T481	compound	energy,production
R2400	T3426	T3424	amod	transcriptional,factor
R2401	T3427	T3413	punct	.,described
R2402	T3429	T3430	det	The,phenotypes
R2403	T3430	T3432	nsubj	phenotypes,are
R2404	T3431	T3430	compound	muscle,phenotypes
R2405	T3433	T3430	acl	described,phenotypes
R2406	T3434	T3433	advmod	here,described
R2407	T3435	T3436	advmod	remarkably,similar
R2408	T3436	T3432	acomp	similar,are
R2409	T3437	T3436	prep	to,similar
R241	T481	T479	pobj	production,for
R2410	T3438	T3437	pobj	those,to
R2411	T3439	T3438	prep	of,those
R2412	T3440	T3441	amod	transgenic,mice
R2413	T3441	T3439	pobj	mice,of
R2414	T3442	T3441	acl	expressing,mice
R2415	T3443	T3444	preconj	either,calcineurin
R2416	T3444	T3442	dobj	calcineurin,expressing
R2417	T3445	T3444	punct	", ",calcineurin
R2418	T3446	T3447	npadvmod	calmodulin,dependent
R2419	T3447	T3449	amod	dependent,kinase
R242	T482	T476	punct	", ",use
R2420	T3448	T3447	punct	-,dependent
R2421	T3449	T3444	conj	kinase,calcineurin
R2422	T3450	T3449	punct	", ",kinase
R2423	T3451	T3449	cc	or,kinase
R2424	T3452	T3449	conj	PGC,kinase
R2425	T3453	T3452	punct	-,PGC
R2426	T3454	T3452	nummod	1α,PGC
R2427	T3455	T3456	punct	(,Naya
R2428	T3456	T3432	meta	Naya,are
R2429	T3457	T3456	nmod	et,Naya
R243	T483	T484	dep	which,provides
R2430	T3458	T3456	nmod	al.,Naya
R2431	T3459	T3456	nummod	2000,Naya
R2432	T3460	T3456	punct	;,Naya
R2433	T3461	T3456	nmod	Lin,Naya
R2434	T3462	T3456	nmod	et,Naya
R2435	T3463	T3456	nmod	al.,Naya
R2436	T3464	T3456	nummod	2002,Naya
R2437	T3465	T3456	punct	;,Naya
R2438	T3466	T3456	nmod	Wu,Naya
R2439	T3467	T3456	nmod	et,Naya
R244	T484	T476	ccomp	provides,use
R2440	T3468	T3456	nmod	al.,Naya
R2441	T3469	T3456	nummod	2002,Naya
R2442	T3470	T3456	punct	),Naya
R2443	T3471	T3432	punct	", ",are
R2444	T3472	T3432	advcl	indicating,are
R2445	T3473	T3474	mark	that,be
R2446	T3474	T3472	ccomp	be,indicating
R2447	T3475	T3474	nsubj	PPARδ,be
R2448	T3476	T3474	aux	could,be
R2449	T3477	T3474	attr	one,be
R245	T485	T486	det	a,supply
R2450	T3478	T3477	prep	of,one
R2451	T3479	T3480	det	the,factors
R2452	T3480	T3478	pobj	factors,of
R2453	T3481	T3480	amod	hypothetical,factors
R2454	T3482	T3480	amod	downstream,factors
R2455	T3483	T3480	compound	transcription,factors
R2456	T3484	T3480	prep	of,factors
R2457	T3485	T3486	det	these,pathways
R2458	T3486	T3484	pobj	pathways,of
R2459	T3487	T3432	punct	.,are
R246	T486	T484	dobj	supply,provides
R2460	T3489	T3490	nsubj	It,is
R2461	T3491	T3490	acomp	important,is
R2462	T3492	T3493	aux	to,note
R2463	T3493	T3490	xcomp	note,is
R2464	T3494	T3495	mark	that,needs
R2465	T3495	T3493	ccomp	needs,note
R2466	T3496	T3495	punct	", ",needs
R2467	T3497	T3495	prep	from,needs
R2468	T3498	T3499	poss	our,studies
R2469	T3499	T3497	pobj	studies,from
R247	T487	T486	amod	stable,supply
R2470	T3500	T3499	nmod	ligand,studies
R2471	T3501	T3500	cc	and,ligand
R2472	T3502	T3500	conj	gain,ligand
R2473	T3503	T3502	punct	-,gain
R2474	T3504	T3502	prep	of,gain
R2475	T3505	T3504	punct	-,of
R2476	T3506	T3504	pobj	function,of
R2477	T3507	T3499	amod	transgenic,studies
R2478	T3508	T3495	punct	", ",needs
R2479	T3509	T3495	nsubj	PPARδ,needs
R248	T488	T487	cc	and,stable
R2480	T3510	T3511	aux	to,activated
R2481	T3511	T3495	xcomp	activated,needs
R2482	T3512	T3511	auxpass	be,activated
R2483	T3513	T3511	prep	in,activated
R2484	T3514	T3513	pobj	order,in
R2485	T3515	T3516	aux	to,direct
R2486	T3516	T3514	acl	direct,order
R2487	T3517	T3518	det	the,switch
R2488	T3518	T3516	dobj	switch,direct
R2489	T3519	T3520	compound	muscle,fiber
R249	T489	T490	amod	long,lasting
R2490	T3520	T3518	compound	fiber,switch
R2491	T3521	T3490	punct	.,is
R2492	T3523	T3524	advmod	Indeed,found
R2493	T3525	T3524	punct	", ",found
R2494	T3526	T3524	prep	in,found
R2495	T3527	T3528	det	a,report
R2496	T3528	T3526	pobj	report,in
R2497	T3529	T3528	amod	recent,report
R2498	T3530	T3528	prep	by,report
R2499	T3531	T3530	pobj	Luquet,by
R25	T138	T116	punct	.,describe
R250	T490	T487	conj	lasting,stable
R2500	T3532	T3533	advmod	et,al.
R2501	T3533	T3531	advmod	al.,Luquet
R2502	T3534	T3531	punct	(,Luquet
R2503	T3535	T3531	npadvmod	2003,Luquet
R2504	T3536	T3531	punct	),Luquet
R2505	T3537	T3524	punct	", ",found
R2506	T3538	T3539	amod	simple,overexpression
R2507	T3539	T3524	nsubjpass	overexpression,found
R2508	T3540	T3539	prep	of,overexpression
R2509	T3541	T3542	amod	wild,type
R251	T491	T490	punct	-,lasting
R2510	T3542	T3544	compound	type,PPARδ
R2511	T3543	T3542	punct	-,type
R2512	T3544	T3540	pobj	PPARδ,of
R2513	T3545	T3539	prep	in,overexpression
R2514	T3546	T3545	pobj	muscle,in
R2515	T3547	T3524	auxpass	was,found
R2516	T3548	T3549	neg	not,be
R2517	T3549	T3524	xcomp	be,found
R2518	T3550	T3549	aux	to,be
R2519	T3551	T3549	acomp	sufficient,be
R252	T492	T486	prep	of,supply
R2520	T3552	T3553	aux	to,promote
R2521	T3553	T3551	xcomp	promote,sufficient
R2522	T3554	T3555	det	a,switch
R2523	T3555	T3553	dobj	switch,promote
R2524	T3556	T3555	compound	fiber,switch
R2525	T3557	T3555	cc	or,switch
R2526	T3558	T3559	compound	obesity,resistance
R2527	T3559	T3555	conj	resistance,switch
R2528	T3560	T3549	punct	", ",be
R2529	T3561	T3562	mark	although,increased
R253	T493	T492	pobj	ATP,of
R2530	T3562	T3549	advcl	increased,be
R2531	T3563	T3564	amod	certain,enzymes
R2532	T3564	T3562	nsubjpass	enzymes,increased
R2533	T3565	T3564	compound	oxidation,enzymes
R2534	T3566	T3562	auxpass	were,increased
R2535	T3567	T3524	punct	.,found
R2536	T3569	T3570	nsubj	This,supports
R2537	T3571	T3572	det	the,model
R2538	T3572	T3570	dobj	model,supports
R2539	T3573	T3572	prep	in,model
R254	T494	T476	punct	", ",use
R2540	T3574	T3573	pobj	Figure,in
R2541	T3575	T3574	nummod	6C,Figure
R2542	T3576	T3577	mark	that,is
R2543	T3577	T3572	acl	is,model
R2544	T3578	T3579	det	the,signal
R2545	T3579	T3577	nsubj	signal,is
R2546	T3580	T3579	amod	activating,signal
R2547	T3581	T3579	cc	or,signal
R2548	T3582	T3579	conj	ligand,signal
R2549	T3583	T3579	punct	", ",signal
R255	T495	T476	cc	and,use
R2550	T3584	T3579	cc	but,signal
R2551	T3585	T3584	neg	not,but
R2552	T3586	T3587	det	the,receptor
R2553	T3587	T3579	conj	receptor,signal
R2554	T3588	T3577	punct	", ",is
R2555	T3589	T3577	acomp	limiting,is
R2556	T3590	T3570	punct	.,supports
R2557	T3592	T3593	advmod	Thus,is
R2558	T3594	T3593	punct	", ",is
R2559	T3595	T3596	compound	PPARδ,activation
R256	T496	T497	advmod	thus,are
R2560	T3596	T3593	nsubj	activation,is
R2561	T3597	T3596	punct	", ",activation
R2562	T3598	T3599	advmod	rather,than
R2563	T3599	T3596	cc	than,activation
R2564	T3600	T3601	advmod	merely,increase
R2565	T3601	T3596	conj	increase,activation
R2566	T3602	T3601	det	an,increase
R2567	T3603	T3601	prep	of,increase
R2568	T3604	T3605	compound	PPARδ,levels
R2569	T3605	T3603	pobj	levels,of
R257	T497	T476	conj	are,use
R2570	T3606	T3593	punct	", ",is
R2571	T3607	T3608	det	an,element
R2572	T3608	T3593	attr	element,is
R2573	T3609	T3608	amod	essential,element
R2574	T3610	T3608	prep	for,element
R2575	T3611	T3612	compound	fiber,switching
R2576	T3612	T3610	pobj	switching,for
R2577	T3613	T3612	cc	and,switching
R2578	T3614	T3615	poss	its,manifestations
R2579	T3615	T3612	conj	manifestations,switching
R258	T498	T499	npadvmod	fatigue,resistant
R2580	T3616	T3615	amod	associated,manifestations
R2581	T3617	T3615	amod	functional,manifestations
R2582	T3618	T3593	punct	.,is
R2583	T3620	T3621	advmod	How,become
R2584	T3622	T3621	aux	might,become
R2585	T3623	T3624	amod	endogenous,PPARδ
R2586	T3624	T3621	nsubj	PPARδ,become
R2587	T3625	T3621	acomp	activated,become
R2588	T3626	T3621	advmod	naturally,become
R2589	T3627	T3621	prep	by,become
R259	T499	T497	acomp	resistant,are
R2590	T3628	T3629	compound	exercise,training
R2591	T3629	T3627	pobj	training,by
R2592	T3630	T3621	punct	?,become
R2593	T3632	T3633	advmod	First,is
R2594	T3634	T3633	punct	", ",is
R2595	T3635	T3633	nsubj	it,is
R2596	T3636	T3633	acomp	possible,is
R2597	T3637	T3638	mark	that,generates
R2598	T3638	T3633	ccomp	generates,is
R2599	T3639	T3638	nsubj	exercise,generates
R26	T140	T141	nsubjpass	This,achieved
R260	T500	T499	punct	-,resistant
R2600	T3640	T3638	cc	or,generates
R2601	T3641	T3638	conj	increases,generates
R2602	T3642	T3643	amod	endogenous,ligands
R2603	T3643	T3641	dobj	ligands,increases
R2604	T3644	T3641	prep	for,increases
R2605	T3645	T3644	pobj	PPARδ,for
R2606	T3646	T3647	mark	as,undergoing
R2607	T3647	T3641	advcl	undergoing,increases
R2608	T3648	T3647	nsubj	tissues,undergoing
R2609	T3649	T3647	aux	are,undergoing
R261	T501	T470	punct	.,are
R2610	T3650	T3651	amod	substantial,increases
R2611	T3651	T3647	dobj	increases,undergoing
R2612	T3652	T3651	prep	in,increases
R2613	T3653	T3654	amod	fatty,acid
R2614	T3654	T3652	pobj	acid,in
R2615	T3655	T3654	punct	-,acid
R2616	T3656	T3654	appos	internalization,acid
R2617	T3657	T3656	cc	and,internalization
R2618	T3658	T3656	conj	burning,internalization
R2619	T3659	T3633	punct	.,is
R262	T503	T504	nmod	Type,fibers
R2620	T3661	T3662	amod	Fatty,acids
R2621	T3662	T3663	nsubj	acids,activate
R2622	T3664	T3662	cc	and,acids
R2623	T3665	T3666	poss	their,metabolites
R2624	T3666	T3662	conj	metabolites,acids
R2625	T3667	T3663	aux	can,activate
R2626	T3668	T3663	dobj	PPARδ,activate
R2627	T3669	T3663	punct	.,activate
R2628	T3671	T3672	det	A,model
R2629	T3672	T3674	nsubj	model,is
R263	T504	T506	nsubj	fibers,comprise
R2630	T3673	T3672	amod	second,model
R2631	T3675	T3676	mark	that,induce
R2632	T3676	T3674	ccomp	induce,is
R2633	T3677	T3676	nsubj	exercise,induce
R2634	T3678	T3676	aux	may,induce
R2635	T3679	T3676	dobj	expression,induce
R2636	T3680	T3679	prep	of,expression
R2637	T3681	T3680	pobj	PGC,of
R2638	T3682	T3681	punct	-,PGC
R2639	T3683	T3681	nummod	1α,PGC
R264	T505	T503	nummod	II,Type
R2640	T3684	T3685	punct	(,Goto
R2641	T3685	T3676	meta	Goto,induce
R2642	T3686	T3685	nmod	et,Goto
R2643	T3687	T3685	nmod	al.,Goto
R2644	T3688	T3685	nummod	2000,Goto
R2645	T3689	T3685	punct	),Goto
R2646	T3690	T3676	cc	and,induce
R2647	T3691	T3692	advmod	thereby,activate
R2648	T3692	T3676	conj	activate,induce
R2649	T3693	T3692	dobj	PPARδ,activate
R265	T507	T508	nummod	three,subtypes
R2650	T3694	T3674	punct	.,is
R2651	T3696	T3697	nsubj	This,is
R2652	T3698	T3697	acomp	consistent,is
R2653	T3699	T3698	prep	with,consistent
R2654	T3700	T3701	amod	previous,work
R2655	T3701	T3699	pobj	work,with
R2656	T3702	T3703	prep	in,shown
R2657	T3703	T3701	relcl	shown,work
R2658	T3704	T3702	pobj	which,in
R2659	T3705	T3703	nsubj	we,shown
R266	T508	T506	dobj	subtypes,comprise
R2660	T3706	T3703	aux	have,shown
R2661	T3707	T3708	mark	that,associates
R2662	T3708	T3703	ccomp	associates,shown
R2663	T3709	T3708	nsubj	PGC,associates
R2664	T3710	T3709	punct	-,PGC
R2665	T3711	T3709	nummod	1α,PGC
R2666	T3712	T3708	advmod	physically,associates
R2667	T3713	T3708	prep	with,associates
R2668	T3714	T3713	pobj	PPARδ,with
R2669	T3715	T3708	prep	in,associates
R267	T509	T508	punct	", ",subtypes
R2670	T3716	T3717	compound	muscle,tissue
R2671	T3717	T3715	pobj	tissue,in
R2672	T3718	T3708	cc	and,associates
R2673	T3719	T3720	aux	can,activate
R2674	T3720	T3708	conj	activate,associates
R2675	T3721	T3720	advmod	powerfully,activate
R2676	T3722	T3720	dobj	it,activate
R2677	T3723	T3724	advmod	even,in
R2678	T3724	T3720	prep	in,activate
R2679	T3725	T3726	det	the,absence
R268	T510	T508	appos	IIa,subtypes
R2680	T3726	T3724	pobj	absence,in
R2681	T3727	T3726	prep	of,absence
R2682	T3728	T3727	pobj	ligands,of
R2683	T3729	T3730	punct	(,Wang
R2684	T3730	T3703	meta	Wang,shown
R2685	T3731	T3730	nmod	et,Wang
R2686	T3732	T3730	nmod	al.,Wang
R2687	T3733	T3730	nummod	2003,Wang
R2688	T3734	T3730	punct	),Wang
R2689	T3735	T3697	punct	.,is
R269	T511	T510	punct	", ",IIa
R2690	T3737	T3738	advmod	Alternatively,activated
R2691	T3739	T3738	punct	", ",activated
R2692	T3740	T3738	nsubjpass	PPARδ,activated
R2693	T3741	T3738	aux	may,activated
R2694	T3742	T3738	auxpass	be,activated
R2695	T3743	T3738	agent	by,activated
R2696	T3744	T3745	det	a,component
R2697	T3745	T3743	pobj	component,by
R2698	T3746	T3745	amod	distal,component
R2699	T3747	T3745	amod	upstream,component
R27	T142	T141	auxpass	was,achieved
R270	T512	T510	conj	IIx,IIa
R2700	T3748	T3745	compound	signaling,component
R2701	T3749	T3750	amod	such,as
R2702	T3750	T3745	prep	as,component
R2703	T3751	T3752	det	a,cascade
R2704	T3752	T3750	pobj	cascade,as
R2705	T3753	T3752	compound	kinase,cascade
R2706	T3754	T3738	punct	.,activated
R2707	T3756	T3757	advmod	Further,dissecting
R2708	T3757	T3758	csubj	dissecting,be
R2709	T3759	T3760	det	the,interactions
R271	T513	T512	punct	", ",IIx
R2710	T3760	T3757	dobj	interactions,dissecting
R2711	T3761	T3760	prep	between,interactions
R2712	T3762	T3761	pobj	PPARδ,between
R2713	T3763	T3762	cc	and,PPARδ
R2714	T3764	T3765	poss	its,components
R2715	T3765	T3762	conj	components,PPARδ
R2716	T3766	T3765	amod	regulatory,components
R2717	T3767	T3758	aux	will,be
R2718	T3768	T3758	acomp	necessary,be
R2719	T3769	T3770	aux	to,understand
R272	T514	T512	cc	and,IIx
R2720	T3770	T3758	advcl	understand,be
R2721	T3771	T3770	advmod	fully,understand
R2722	T3772	T3773	det	the,basis
R2723	T3773	T3770	dobj	basis,understand
R2724	T3774	T3773	amod	molecular,basis
R2725	T3775	T3773	prep	of,basis
R2726	T3776	T3777	compound	muscle,fiber
R2727	T3777	T3778	compound	fiber,determination
R2728	T3778	T3775	pobj	determination,of
R2729	T3779	T3773	amod	pertinent,basis
R273	T515	T512	conj	IIb,IIx
R2730	T3780	T3779	prep	to,pertinent
R2731	T3781	T3782	compound	exercise,training
R2732	T3782	T3780	pobj	training,to
R2733	T3783	T3758	punct	.,be
R2734	T3785	T3786	amod	Skeletal,muscle
R2735	T3786	T3787	nsubj	muscle,is
R2736	T3788	T3789	det	a,site
R2737	T3789	T3787	attr	site,is
R2738	T3790	T3789	amod	major,site
R2739	T3791	T3792	aux	to,regulate
R274	T516	T506	punct	.,comprise
R2740	T3792	T3789	advcl	regulate,site
R2741	T3793	T3794	amod	whole,body
R2742	T3794	T3796	nmod	body,metabolism
R2743	T3795	T3794	punct	-,body
R2744	T3796	T3792	dobj	metabolism,regulate
R2745	T3797	T3798	amod	fatty,acid
R2746	T3798	T3796	nmod	acid,metabolism
R2747	T3799	T3798	punct	-,acid
R2748	T3800	T3798	cc	and,acid
R2749	T3801	T3798	conj	glucose,acid
R275	T518	T519	compound	Type,IIb
R2750	T3802	T3787	punct	.,is
R2751	T3804	T3805	nsubj	We,show
R2752	T3806	T3807	mark	that,are
R2753	T3807	T3805	ccomp	are,show
R2754	T3808	T3807	nsubj	mice,are
R2755	T3809	T3808	prep	with,mice
R2756	T3810	T3811	amod	increased,fibers
R2757	T3811	T3809	pobj	fibers,with
R2758	T3812	T3811	amod	oxidative,fibers
R2759	T3813	T3807	acomp	resistant,are
R276	T519	T520	compound	IIb,fibers
R2760	T3814	T3813	prep	to,resistant
R2761	T3815	T3816	amod	high,fat
R2762	T3816	T3818	npadvmod	fat,induced
R2763	T3817	T3816	punct	-,fat
R2764	T3818	T3820	amod	induced,obesity
R2765	T3819	T3818	punct	-,induced
R2766	T3820	T3814	pobj	obesity,to
R2767	T3821	T3820	cc	and,obesity
R2768	T3822	T3823	compound	glucose,intolerance
R2769	T3823	T3820	conj	intolerance,obesity
R277	T520	T521	nsubj	fibers,have
R2770	T3824	T3805	punct	.,show
R2771	T3826	T3827	advmod	Moreover,provide
R2772	T3828	T3827	punct	", ",provide
R2773	T3829	T3830	compound	ligand,studies
R2774	T3830	T3827	nsubj	studies,provide
R2775	T3831	T3832	amod	compelling,evidence
R2776	T3832	T3827	dobj	evidence,provide
R2777	T3833	T3834	mark	that,produce
R2778	T3834	T3832	acl	produce,evidence
R2779	T3835	T3834	nsubj	activation,produce
R278	T522	T523	det	the,levels
R2780	T3836	T3835	prep	of,activation
R2781	T3837	T3838	amod	endogenous,PPARδ
R2782	T3838	T3836	pobj	PPARδ,of
R2783	T3839	T3834	aux	can,produce
R2784	T3840	T3841	amod	similar,effects
R2785	T3841	T3834	dobj	effects,produce
R2786	T3842	T3827	punct	.,provide
R2787	T3844	T3845	aux	Might,have
R2788	T3846	T3845	nsubj	PPARδ,have
R2789	T3847	T3848	det	any,effects
R279	T523	T521	dobj	levels,have
R2790	T3848	T3845	dobj	effects,have
R2791	T3849	T3848	amod	beneficial,effects
R2792	T3850	T3848	prep	on,effects
R2793	T3851	T3852	compound	glucose,metabolism
R2794	T3852	T3850	pobj	metabolism,on
R2795	T3853	T3845	prep	in,have
R2796	T3854	T3855	det	the,condition
R2797	T3855	T3853	pobj	condition,in
R2798	T3856	T3855	amod	lean,condition
R2799	T3857	T3845	punct	?,have
R28	T143	T141	agent	by,achieved
R280	T524	T523	amod	lowest,levels
R2800	T3859	T3860	nsubjpass	This,explored
R2801	T3860	T3864	ccomp	explored,confined
R2802	T3861	T3860	aux	has,explored
R2803	T3862	T3860	neg	not,explored
R2804	T3863	T3860	auxpass	been,explored
R2805	T3865	T3864	punct	;,confined
R2806	T3866	T3864	advmod	however,confined
R2807	T3867	T3864	punct	", ",confined
R2808	T3868	T3869	compound	insulin,resistance
R2809	T3869	T3864	nsubjpass	resistance,confined
R281	T525	T523	prep	of,levels
R2810	T3870	T3869	prep	in,resistance
R2811	T3871	T3872	det	the,elderly
R2812	T3872	T3870	pobj	elderly,in
R2813	T3873	T3864	auxpass	is,confined
R2814	T3874	T3875	advmod	mostly,to
R2815	T3875	T3864	prep	to,confined
R2816	T3876	T3877	amod	skeletal,muscle
R2817	T3877	T3875	pobj	muscle,to
R2818	T3878	T3864	cc	and,confined
R2819	T3879	T3880	aux	may,be
R282	T526	T527	amod	mitochondrial,content
R2820	T3880	T3864	conj	be,confined
R2821	T3881	T3880	prep	due,be
R2822	T3882	T3881	pcomp	to,due
R2823	T3883	T3881	pobj	reduction,due
R2824	T3884	T3883	prep	of,reduction
R2825	T3885	T3886	amod	mitochondrial,number
R2826	T3886	T3884	pobj	number,of
R2827	T3887	T3886	cc	and,number
R2828	T3888	T3887	punct	/,and
R2829	T3889	T3887	cc	or,and
R283	T527	T525	pobj	content,of
R2830	T3890	T3886	conj	function,number
R2831	T3891	T3892	punct	(,Petersen
R2832	T3892	T3880	meta	Petersen,be
R2833	T3893	T3892	nmod	et,Petersen
R2834	T3894	T3892	nmod	al.,Petersen
R2835	T3895	T3892	nummod	2003,Petersen
R2836	T3896	T3892	punct	),Petersen
R2837	T3897	T3864	punct	.,confined
R2838	T3899	T3900	det	The,ability
R2839	T3900	T3901	nsubj	ability,suggests
R284	T528	T527	cc	and,content
R2840	T3902	T3900	prep	of,ability
R2841	T3903	T3902	pobj	PPARδ,of
R2842	T3904	T3905	aux	to,stimulate
R2843	T3905	T3900	acl	stimulate,ability
R2844	T3906	T3907	amod	mitochondrial,biogenesis
R2845	T3907	T3905	dobj	biogenesis,stimulate
R2846	T3908	T3907	cc	and,biogenesis
R2847	T3909	T3910	amod	oxidative,function
R2848	T3910	T3907	conj	function,biogenesis
R2849	T3911	T3912	mark	that,be
R285	T529	T530	amod	oxidative,enzymes
R2850	T3912	T3901	ccomp	be,suggests
R2851	T3913	T3912	nsubj	PPARδ,be
R2852	T3914	T3912	aux	could,be
R2853	T3915	T3912	acomp	important,be
R2854	T3916	T3912	prep	for,be
R2855	T3917	T3916	pobj	control,for
R2856	T3918	T3917	prep	of,control
R2857	T3919	T3920	compound	insulin,resistance
R2858	T3920	T3918	pobj	resistance,of
R2859	T3921	T3912	prep	during,be
R286	T530	T527	conj	enzymes,content
R2860	T3922	T3923	amod	normal,aging
R2861	T3923	T3921	pobj	aging,during
R2862	T3924	T3901	punct	.,suggests
R2863	T3926	T3927	advmod	Together,indicate
R2864	T3928	T3927	punct	", ",indicate
R2865	T3929	T3930	det	these,data
R2866	T3930	T3927	nsubj	data,indicate
R2867	T3931	T3932	mark	that,comprise
R2868	T3932	T3927	ccomp	comprise,indicate
R2869	T3933	T3932	nsubj	PPARδ,comprise
R287	T531	T521	punct	", ",have
R2870	T3934	T3933	cc	and,PPARδ
R2871	T3935	T3936	poss	its,ligands
R2872	T3936	T3933	conj	ligands,PPARδ
R2873	T3937	T3938	det	a,switch
R2874	T3938	T3932	dobj	switch,comprise
R2875	T3939	T3938	amod	key,switch
R2876	T3940	T3938	amod	molecular,switch
R2877	T3941	T3942	aux	to,regulate
R2878	T3942	T3938	advcl	regulate,switch
R2879	T3943	T3944	compound	muscle,fiber
R288	T532	T521	conj	rely,have
R2880	T3944	T3945	compound	fiber,specification
R2881	T3945	T3942	dobj	specification,regulate
R2882	T3946	T3945	punct	", ",specification
R2883	T3947	T3948	compound	obesity,resistance
R2884	T3948	T3945	conj	resistance,specification
R2885	T3949	T3948	punct	", ",resistance
R2886	T3950	T3951	compound	insulin,sensitivity
R2887	T3951	T3948	conj	sensitivity,resistance
R2888	T3952	T3951	punct	", ",sensitivity
R2889	T3953	T3951	cc	and,sensitivity
R289	T533	T532	prep	on,rely
R2890	T3954	T3951	punct	", ",sensitivity
R2891	T3955	T3956	advmod	most,surprisingly
R2892	T3956	T3957	advmod	surprisingly,endurance
R2893	T3957	T3951	conj	endurance,sensitivity
R2894	T3958	T3957	punct	", ",endurance
R2895	T3959	T3957	amod	physical,endurance
R2896	T3960	T3927	punct	.,indicate
R2897	T3962	T3963	det	This,work
R2898	T3963	T3964	nsubj	work,demonstrates
R2899	T3965	T3966	mark	that,manipulated
R29	T144	T145	amod	targeted,expression
R290	T534	T535	amod	glycolytic,metabolism
R2900	T3966	T3964	ccomp	manipulated,demonstrates
R2901	T3967	T3968	amod	complex,properties
R2902	T3968	T3966	nsubjpass	properties,manipulated
R2903	T3969	T3968	amod	physiologic,properties
R2904	T3970	T3971	amod	such,as
R2905	T3971	T3968	prep	as,properties
R2906	T3972	T3971	pobj	fatigue,as
R2907	T3973	T3972	punct	", ",fatigue
R2908	T3974	T3972	conj	endurance,fatigue
R2909	T3975	T3974	punct	", ",endurance
R291	T535	T533	pobj	metabolism,on
R2910	T3976	T3974	cc	and,endurance
R2911	T3977	T3978	compound	running,capacity
R2912	T3978	T3974	conj	capacity,endurance
R2913	T3979	T3966	aux	can,manipulated
R2914	T3980	T3966	auxpass	be,manipulated
R2915	T3981	T3966	advmod	genetically,manipulated
R2916	T3982	T3964	punct	.,demonstrates
R2917	T4059	T4058	punct	.,Animals
R2918	T4061	T4062	det	The,domain
R2919	T4062	T4064	nsubjpass	domain,fused
R292	T536	T532	prep	as,rely
R2920	T4063	T4062	compound	transactivation,domain
R2921	T4065	T4066	punct	(,residues
R2922	T4066	T4062	parataxis	residues,domain
R2923	T4067	T4066	nummod	78,residues
R2924	T4068	T4069	compound	amino,acid
R2925	T4069	T4066	compound	acid,residues
R2926	T4070	T4066	punct	", ",residues
R2927	T4071	T4066	acl	corresponding,residues
R2928	T4072	T4071	prep	to,corresponding
R2929	T4073	T4074	nmod	residues,413
R293	T537	T538	det	a,source
R2930	T4074	T4072	pobj	413,to
R2931	T4075	T4076	punct	–,490
R2932	T4076	T4074	prep	490,413
R2933	T4077	T4066	punct	),residues
R2934	T4078	T4062	prep	of,domain
R2935	T4079	T4078	pobj	VP16,of
R2936	T4080	T4064	auxpass	was,fused
R2937	T4081	T4064	prep	in,fused
R2938	T4082	T4081	pobj	frame,in
R2939	T4083	T4064	prep	with,fused
R294	T538	T536	pobj	source,as
R2940	T4084	T4085	det	the,terminus
R2941	T4085	T4083	pobj	terminus,with
R2942	T4086	T4085	compound	N,terminus
R2943	T4087	T4085	punct	-,terminus
R2944	T4088	T4085	prep	of,terminus
R2945	T4089	T4090	compound	mouse,PPARδ
R2946	T4090	T4088	pobj	PPARδ,of
R2947	T4091	T4064	punct	.,fused
R2948	T4093	T4094	det	The,cDNA
R2949	T4094	T4099	nsubjpass	cDNA,placed
R295	T539	T538	amod	major,source
R2950	T4095	T4096	compound	VP16,PPARδ
R2951	T4096	T4094	compound	PPARδ,cDNA
R2952	T4097	T4096	punct	-,PPARδ
R2953	T4098	T4094	compound	fusion,cDNA
R2954	T4100	T4099	auxpass	was,placed
R2955	T4101	T4099	advmod	downstream,placed
R2956	T4102	T4101	prep	of,downstream
R2957	T4103	T4104	det	the,promoter
R2958	T4104	T4102	pobj	promoter,of
R2959	T4105	T4104	amod	human,promoter
R296	T540	T538	compound	energy,source
R2960	T4106	T4107	npadvmod	α,skeletal
R2961	T4107	T4104	amod	skeletal,promoter
R2962	T4108	T4107	punct	-,skeletal
R2963	T4109	T4104	compound	actin,promoter
R2964	T4110	T4111	punct	(,Brennan
R2965	T4111	T4104	meta	Brennan,promoter
R2966	T4112	T4111	cc	and,Brennan
R2967	T4135	T4133	cc	and,purified
R2968	T4136	T4133	conj	injected,purified
R2969	T4137	T4136	prep	into,injected
R297	T541	T532	punct	", ",rely
R2970	T4138	T4139	nmod	C57BL,6J
R2971	T4139	T4141	nmod	6J,zygotes
R2972	T4140	T4139	punct	/,6J
R2973	T4141	T4137	pobj	zygotes,into
R2974	T4142	T4139	punct	×,6J
R2975	T4143	T4139	appos	CBA,6J
R2976	T4144	T4141	compound	F1,zygotes
R2977	T4145	T4133	punct	.,purified
R2978	T4147	T4148	amod	Transgenic,mice
R2979	T4148	T4149	nsubjpass	mice,backcrossed
R298	T542	T532	cc	and,rely
R2980	T4150	T4149	auxpass	were,backcrossed
R2981	T4151	T4149	prep	with,backcrossed
R2982	T4152	T4153	compound	C57BL,6J
R2983	T4153	T4151	pobj	6J,with
R2984	T4154	T4153	punct	/,6J
R2985	T4155	T4149	prep	for,backcrossed
R2986	T4156	T4157	nummod	two,generations
R2987	T4157	T4155	pobj	generations,for
R2988	T4158	T4149	punct	.,backcrossed
R2989	T4160	T4161	amod	Wild,type
R299	T543	T532	conj	are,rely
R2990	T4161	T4163	compound	type,littermates
R2991	T4162	T4161	punct	-,type
R2992	T4163	T4164	nsubjpass	littermates,used
R2993	T4165	T4164	auxpass	were,used
R2994	T4166	T4164	prep	as,used
R2995	T4167	T4166	pobj	controls,as
R2996	T4168	T4164	prep	throughout,used
R2997	T4169	T4170	det	the,study
R2998	T4170	T4168	pobj	study,throughout
R2999	T4171	T4164	punct	.,used
R3	T115	T116	nsubj	We,describe
R30	T145	T143	pobj	expression,by
R300	T544	T543	acomp	susceptible,are
R3000	T4173	T4174	prep	On,had
R3001	T4175	T4176	amod	normal,diet
R3002	T4176	T4173	pobj	diet,On
R3003	T4177	T4176	compound	chow,diet
R3004	T4178	T4174	punct	", ",had
R3005	T4179	T4180	det	the,mice
R3006	T4180	T4174	nsubj	mice,had
R3007	T4181	T4180	amod	transgenic,mice
R3008	T4182	T4180	cc	and,mice
R3009	T4183	T4184	compound	control,littermates
R301	T545	T544	prep	to,susceptible
R3010	T4184	T4180	conj	littermates,mice
R3011	T4185	T4180	acl	used,mice
R3012	T4186	T4185	advmod	here,used
R3013	T4187	T4188	amod	similar,weights
R3014	T4188	T4174	dobj	weights,had
R3015	T4189	T4188	compound	body,weights
R3016	T4190	T4174	punct	.,had
R3017	T4192	T4193	npadvmod	PPARδ,null
R3018	T4193	T4195	amod	null,mice
R3019	T4194	T4193	punct	-,null
R302	T546	T545	pobj	fatigue,to
R3020	T4195	T4196	nsubjpass	mice,generated
R3021	T4197	T4196	auxpass	were,generated
R3022	T4198	T4196	advmod	previously,generated
R3023	T4199	T4200	punct	(,Barak
R3024	T4200	T4196	meta	Barak,generated
R3025	T4201	T4200	nmod	et,Barak
R3026	T4202	T4200	nmod	al.,Barak
R3027	T4203	T4200	nummod	2002,Barak
R3028	T4204	T4200	punct	),Barak
R3029	T4205	T4196	punct	.,generated
R303	T547	T521	punct	", ",have
R3030	T4207	T4208	nsubjpass	Mice,fed
R3031	T4209	T4208	auxpass	were,fed
R3032	T4210	T4211	preconj	either,chow
R3033	T4211	T4208	dobj	chow,fed
R3034	T4212	T4211	det	a,chow
R3035	T4213	T4211	amod	standard,chow
R3036	T4214	T4211	prep	with,chow
R3037	T4215	T4216	nummod	4,%
R3038	T4216	T4217	nmod	%,content
R3039	T4217	T4214	pobj	content,with
R304	T548	T549	mark	while,lie
R3040	T4218	T4219	punct	(,w
R3041	T4219	T4217	parataxis	w,content
R3042	T4220	T4221	punct	/,w
R3043	T4221	T4219	prep	w,w
R3044	T4222	T4219	punct	),w
R3045	T4223	T4217	compound	fat,content
R3046	T4224	T4225	punct	(,Teklad
R3047	T4225	T4211	parataxis	Teklad,chow
R3048	T4226	T4225	compound	Harlan,Teklad
R3049	T4227	T4225	punct	", ",Teklad
R305	T549	T521	advcl	lie,have
R3050	T4228	T4225	npadvmod	Harlan,Teklad
R3051	T4229	T4225	punct	", ",Teklad
R3052	T4230	T4225	npadvmod	Indianapolis,Teklad
R3053	T4231	T4225	punct	", ",Teklad
R3054	T4232	T4225	npadvmod	Indiana,Teklad
R3055	T4233	T4225	punct	", ",Teklad
R3056	T4234	T4235	compound	United,States
R3057	T4235	T4225	npadvmod	States,Teklad
R3058	T4236	T4225	punct	),Teklad
R3059	T4237	T4211	cc	or,chow
R306	T550	T551	det	the,functions
R3060	T4238	T4239	det	a,diet
R3061	T4239	T4211	conj	diet,chow
R3062	T4240	T4241	amod	high,fat
R3063	T4241	T4239	compound	fat,diet
R3064	T4242	T4241	punct	-,fat
R3065	T4243	T4239	acl	containing,diet
R3066	T4244	T4245	nummod	35,%
R3067	T4245	T4246	nmod	%,content
R3068	T4246	T4243	dobj	content,containing
R3069	T4247	T4248	punct	(,w
R307	T551	T549	nsubj	functions,lie
R3070	T4248	T4246	parataxis	w,content
R3071	T4249	T4250	punct	/,w
R3072	T4250	T4248	prep	w,w
R3073	T4251	T4248	punct	),w
R3074	T4252	T4246	compound	fat,content
R3075	T4253	T4254	punct	(,F3282
R3076	T4254	T4239	parataxis	F3282,diet
R3077	T4255	T4254	compound	product,F3282
R3078	T4256	T4254	punct	", ",F3282
R3079	T4257	T4254	npadvmod	Bioserv,F3282
R308	T552	T551	amod	oxidative,functions
R3080	T4258	T4254	punct	", ",F3282
R3081	T4259	T4254	npadvmod	Frenchtown,F3282
R3082	T4260	T4254	punct	", ",F3282
R3083	T4261	T4262	compound	New,Jersey
R3084	T4262	T4254	npadvmod	Jersey,F3282
R3085	T4263	T4254	punct	", ",F3282
R3086	T4264	T4265	compound	United,States
R3087	T4265	T4254	npadvmod	States,F3282
R3088	T4266	T4254	punct	),F3282
R3089	T4267	T4268	mark	as,indicated
R309	T553	T552	cc	and,oxidative
R3090	T4268	T4208	advcl	indicated,fed
R3091	T4269	T4208	punct	.,fed
R3092	T4271	T4272	prep	For,synthesized
R3093	T4273	T4274	compound	ligand,experiments
R3094	T4274	T4271	pobj	experiments,For
R3095	T4275	T4272	punct	", ",synthesized
R3096	T4276	T4272	nsubj	we,synthesized
R3097	T4277	T4278	det	the,compound
R3098	T4278	T4272	dobj	compound,synthesized
R3099	T4279	T4278	compound	GW501516,compound
R31	T146	T145	prep	of,expression
R310	T554	T552	conj	contraction,oxidative
R3100	T4280	T4272	cc	and,synthesized
R3101	T4281	T4282	nsubjpass	mice,gavaged
R3102	T4282	T4272	conj	gavaged,synthesized
R3103	T4283	T4282	auxpass	were,gavaged
R3104	T4284	T4282	advmod	orally,gavaged
R3105	T4285	T4282	advmod	daily,gavaged
R3106	T4286	T4287	punct	(,mg
R3107	T4287	T4282	parataxis	mg,gavaged
R3108	T4288	T4287	nummod	10,mg
R3109	T4289	T4290	punct	/,kg
R311	T555	T551	prep	of,functions
R3110	T4290	T4287	prep	kg,mg
R3111	T4291	T4287	cc	or,mg
R3112	T4292	T4287	conj	vehicle,mg
R3113	T4293	T4292	advmod	alone,vehicle
R3114	T4294	T4287	punct	),mg
R3115	T4295	T4282	punct	.,gavaged
R3116	T4113	T4111	conj	Hardeman,Brennan
R3117	T4114	T4113	nummod	1993,Hardeman
R3118	T4115	T4113	punct	),Hardeman
R3119	T4116	T4101	punct	", ",downstream
R312	T556	T557	compound	type,IIa
R3120	T4117	T4101	cc	and,downstream
R3121	T4118	T4101	conj	upstream,downstream
R3122	T4119	T4118	prep	of,upstream
R3123	T4120	T4121	det	the,sequence
R3124	T4121	T4119	pobj	sequence,of
R3125	T4122	T4123	nmod	SV40,intron
R3126	T4123	T4121	nmod	intron,sequence
R3127	T4124	T4123	punct	/,intron
R3128	T4125	T4126	nmod	poly,A
R3129	T4126	T4123	appos	A,intron
R313	T557	T555	pobj	IIa,of
R3130	T4127	T4126	punct	(,A
R3131	T4128	T4126	punct	),A
R3132	T4129	T4099	punct	.,placed
R3133	T4131	T4132	det	The,transgene
R3134	T4132	T4133	nsubjpass	transgene,purified
R3135	T4134	T4133	auxpass	was,purified
R3136	T4318	T4319	compound	Gene,expression
R3137	T4319	T4320	compound	expression,analysis
R3138	T4321	T4320	cc	and,analysis
R3139	T4322	T4323	amod	physiological,studies
R314	T558	T557	cc	and,IIa
R3140	T4323	T4320	conj	studies,analysis
R3141	T4325	T4326	compound	Mouse,clones
R3142	T4326	T4328	nsubjpass	clones,obtained
R3143	T4327	T4326	compound	EST,clones
R3144	T4329	T4328	auxpass	were,obtained
R3145	T4330	T4328	prep	from,obtained
R3146	T4331	T4330	pobj	ATCC,from
R3147	T4332	T4333	punct	(,Manassas
R3148	T4333	T4331	parataxis	Manassas,ATCC
R3149	T4334	T4333	punct	", ",Manassas
R315	T559	T557	conj	IIx,IIa
R3150	T4335	T4333	npadvmod	Virginia,Manassas
R3151	T4336	T4333	punct	", ",Manassas
R3152	T4337	T4338	compound	United,States
R3153	T4338	T4333	npadvmod	States,Manassas
R3154	T4339	T4333	punct	),Manassas
R3155	T4340	T4328	punct	", ",obtained
R3156	T4341	T4328	conj	verified,obtained
R3157	T4342	T4341	prep	by,verified
R3158	T4343	T4342	pobj	sequencing,by
R3159	T4344	T4341	punct	", ",verified
R316	T560	T549	prep	between,lie
R3160	T4345	T4341	cc	and,verified
R3161	T4346	T4341	conj	used,verified
R3162	T4347	T4346	prep	as,used
R3163	T4348	T4349	compound	Northern,probes
R3164	T4349	T4347	pobj	probes,as
R3165	T4350	T4328	punct	.,obtained
R3166	T4352	T4353	nsubjpass	Antibodies,obtained
R3167	T4354	T4353	auxpass	were,obtained
R3168	T4355	T4353	prep	from,obtained
R3169	T4356	T4357	compound	Santa,Cruz
R317	T561	T562	nmod	type,IIb
R3170	T4357	T4358	compound	Cruz,Biotechnology
R3171	T4358	T4355	pobj	Biotechnology,from
R3172	T4359	T4358	punct	(,Biotechnology
R3173	T4360	T4361	compound	Santa,Cruz
R3174	T4361	T4358	npadvmod	Cruz,Biotechnology
R3175	T4362	T4358	punct	", ",Biotechnology
R3176	T4363	T4358	npadvmod	California,Biotechnology
R3177	T4364	T4358	punct	", ",Biotechnology
R3178	T4365	T4366	compound	United,States
R3179	T4366	T4358	npadvmod	States,Biotechnology
R318	T562	T560	pobj	IIb,between
R3180	T4367	T4358	punct	),Biotechnology
R3181	T4368	T4353	punct	.,obtained
R3182	T4370	T4371	amod	Total,extracts
R3183	T4371	T4374	nsubjpass	extracts,prepared
R3184	T4372	T4373	compound	muscle,protein
R3185	T4373	T4371	compound	protein,extracts
R3186	T4375	T4376	punct	(,Lin
R3187	T4376	T4371	meta	Lin,extracts
R3188	T4377	T4376	nmod	et,Lin
R3189	T4378	T4376	nmod	al.,Lin
R319	T563	T562	nummod	I,IIb
R3190	T4379	T4376	nummod	2002,Lin
R3191	T4380	T4376	punct	),Lin
R3192	T4381	T4371	cc	and,extracts
R3193	T4382	T4383	amod	nuclear,proteins
R3194	T4383	T4371	conj	proteins,extracts
R3195	T4384	T4385	punct	(,Wang
R3196	T4385	T4383	meta	Wang,proteins
R3197	T4386	T4385	nmod	et,Wang
R3198	T4387	T4385	nmod	al.,Wang
R3199	T4388	T4385	nummod	2003,Wang
R32	T147	T148	det	an,form
R320	T564	T562	cc	and,IIb
R3200	T4389	T4385	punct	),Wang
R3201	T4390	T4374	auxpass	were,prepared
R3202	T4391	T4392	mark	as,described
R3203	T4392	T4374	advcl	described,prepared
R3204	T4393	T4374	punct	.,prepared
R3205	T4395	T4396	amod	Prior,to
R3206	T4396	T4397	prep	to,accustomed
R3207	T4398	T4399	det	the,test
R3208	T4399	T4396	pobj	test,to
R3209	T4400	T4399	compound	exercise,test
R321	T565	T566	punct	(,Booth
R3210	T4401	T4399	compound	performance,test
R3211	T4402	T4397	punct	", ",accustomed
R3212	T4403	T4404	det	the,mice
R3213	T4404	T4397	nsubjpass	mice,accustomed
R3214	T4405	T4397	auxpass	were,accustomed
R3215	T4406	T4397	prep	to,accustomed
R3216	T4407	T4408	det	the,treadmill
R3217	T4408	T4406	pobj	treadmill,to
R3218	T4409	T4410	punct	(,Instruments
R3219	T4410	T4408	parataxis	Instruments,treadmill
R322	T566	T549	meta	Booth,lie
R3220	T4411	T4410	compound	Columbus,Instruments
R3221	T4412	T4410	punct	", ",Instruments
R3222	T4413	T4410	npadvmod	Columbus,Instruments
R3223	T4414	T4410	punct	", ",Instruments
R3224	T4415	T4410	npadvmod	Ohio,Instruments
R3225	T4416	T4410	punct	", ",Instruments
R3226	T4417	T4418	compound	United,States
R3227	T4418	T4410	npadvmod	States,Instruments
R3228	T4419	T4410	punct	),Instruments
R3229	T4420	T4397	prep	with,accustomed
R323	T567	T566	cc	and,Booth
R3230	T4421	T4422	det	a,run
R3231	T4422	T4420	pobj	run,with
R3232	T4423	T4424	nummod	5,min
R3233	T4424	T4422	compound	min,run
R3234	T4425	T4424	punct	-,min
R3235	T4426	T4422	prep	at,run
R3236	T4427	T4428	nummod	7,m
R3237	T4428	T4426	pobj	m,at
R3238	T4429	T4430	punct	/,min
R3239	T4430	T4428	prep	min,m
R324	T568	T566	conj	Thomason,Booth
R3240	T4431	T4397	npadvmod	once,accustomed
R3241	T4432	T4431	prep	per,once
R3242	T4433	T4432	pobj	day,per
R3243	T4434	T4397	prep	for,accustomed
R3244	T4435	T4436	nummod	2,d
R3245	T4436	T4434	pobj	d,for
R3246	T4437	T4397	punct	.,accustomed
R3247	T4439	T4440	det	The,regimen
R3248	T4440	T4443	nsubj	regimen,was
R3249	T4441	T4440	compound	exercise,regimen
R325	T569	T568	nummod	1991,Thomason
R3250	T4442	T4440	compound	test,regimen
R3251	T4444	T4445	nummod	10,m
R3252	T4445	T4443	attr	m,was
R3253	T4446	T4447	punct	/,min
R3254	T4447	T4445	prep	min,m
R3255	T4448	T4443	prep	for,was
R3256	T4449	T4450	det	the,min
R3257	T4450	T4448	pobj	min,for
R3258	T4451	T4450	amod	first,min
R3259	T4452	T4450	nummod	60,min
R326	T570	T568	punct	;,Thomason
R3260	T4453	T4443	punct	", ",was
R3261	T4454	T4443	prep	followed,was
R3262	T4455	T4454	prep	by,followed
R3263	T4456	T4457	nummod	1,m
R3264	T4457	T4458	nmod	m,increment
R3265	T4458	T4455	pobj	increment,by
R3266	T4459	T4460	punct	/,min
R3267	T4460	T4457	prep	min,m
R3268	T4461	T4458	nmod	increases,increment
R3269	T4462	T4458	prep	at,increment
R327	T571	T568	conj	Berchtold,Thomason
R3270	T4463	T4464	nummod	15,min
R3271	T4464	T4466	compound	min,intervals
R3272	T4465	T4464	punct	-,min
R3273	T4466	T4462	pobj	intervals,at
R3274	T4467	T4443	punct	.,was
R3275	T4469	T4470	nsubjpass	Exhaustion,defined
R3276	T4471	T4470	auxpass	was,defined
R3277	T4472	T4473	advmod	when,were
R3278	T4473	T4470	advcl	were,defined
R3279	T4474	T4473	nsubj	mice,were
R328	T572	T571	nmod	et,Berchtold
R3280	T4475	T4473	acomp	unable,were
R3281	T4476	T4477	aux	to,avoid
R3282	T4477	T4475	xcomp	avoid,unable
R3283	T4478	T4479	amod	repetitive,shocks
R3284	T4479	T4477	dobj	shocks,avoid
R3285	T4480	T4479	amod	electrical,shocks
R3286	T4481	T4470	punct	.,defined
R3287	T4506	T4507	compound	Muscle,fiber
R3288	T4507	T4508	compound	fiber,typing
R3289	T4509	T4508	cc	and,typing
R329	T573	T571	nmod	al.,Berchtold
R3290	T4510	T4511	amod	mitochondrial,DNA
R3291	T4511	T4512	compound	DNA,isolation
R3292	T4512	T4508	conj	isolation,typing
R3293	T4514	T4515	compound	Muscle,fiber
R3294	T4515	T4516	compound	fiber,typing
R3295	T4516	T4517	nsubjpass	typing,performed
R3296	T4518	T4517	auxpass	was,performed
R3297	T4519	T4517	advmod	essentially,performed
R3298	T4520	T4517	advcl	using,performed
R3299	T4521	T4522	amod	metachromatic,dye
R33	T148	T146	pobj	form,of
R330	T574	T571	nummod	2000,Berchtold
R3300	T4522	T4523	nmod	dye,methods
R3301	T4523	T4520	dobj	methods,using
R3302	T4524	T4522	punct	–,dye
R3303	T4525	T4522	appos	ATPase,dye
R3304	T4526	T4527	mark	as,described
R3305	T4527	T4517	advcl	described,performed
R3306	T4528	T4529	punct	(,Ogilvie
R3307	T4529	T4527	meta	Ogilvie,described
R3308	T4530	T4529	cc	and,Ogilvie
R3309	T4531	T4529	conj	Feeback,Ogilvie
R331	T575	T571	punct	;,Berchtold
R3310	T4532	T4531	nummod	1990,Feeback
R3311	T4533	T4531	punct	),Feeback
R3312	T4534	T4517	punct	.,performed
R3313	T4536	T4537	compound	Muscle,mitochondria
R3314	T4537	T4538	nsubjpass	mitochondria,isolated
R3315	T4539	T4538	auxpass	were,isolated
R3316	T4540	T4541	punct	(,Scholte
R3317	T4541	T4538	meta	Scholte,isolated
R3318	T4542	T4541	nmod	et,Scholte
R3319	T4543	T4541	nmod	al.,Scholte
R332	T576	T571	conj	Olson,Berchtold
R3320	T4544	T4541	nummod	1997,Scholte
R3321	T4545	T4541	punct	),Scholte
R3322	T4546	T4538	punct	.,isolated
R3323	T4548	T4549	amod	Mitochondrial,DNA
R3324	T4549	T4550	nsubjpass	DNA,prepared
R3325	T4551	T4550	auxpass	was,prepared
R3326	T4552	T4550	cc	and,prepared
R3327	T4553	T4550	conj	analyzed,prepared
R3328	T4554	T4553	prep	on,analyzed
R3329	T4555	T4556	nummod	1,%
R333	T577	T576	cc	and,Olson
R3330	T4556	T4557	compound	%,gel
R3331	T4557	T4554	pobj	gel,on
R3332	T4558	T4557	compound	agarose,gel
R3333	T4559	T4550	punct	.,prepared
R3334	T4562	T4563	amod	Statistical,analysis
R3335	T4565	T4566	nsubjpass	Number,indicated
R3336	T4567	T4565	prep	of,Number
R3337	T4568	T4567	pobj	mice,of
R3338	T4569	T4565	prep	for,Number
R3339	T4570	T4571	det	each,group
R334	T578	T576	conj	Williams,Olson
R3340	T4571	T4569	pobj	group,for
R3341	T4572	T4571	acl	used,group
R3342	T4573	T4572	prep	in,used
R3343	T4574	T4573	pobj	experiments,in
R3344	T4575	T4566	auxpass	is,indicated
R3345	T4576	T4566	prep	in,indicated
R3346	T4577	T4578	compound	figure,legends
R3347	T4578	T4576	pobj	legends,in
R3348	T4579	T4566	punct	.,indicated
R3349	T4581	T4582	nsubjpass	Values,presented
R335	T579	T578	nummod	2000,Williams
R3350	T4583	T4582	auxpass	are,presented
R3351	T4584	T4582	prep	as,presented
R3352	T4585	T4586	nmod	mean,SEM
R3353	T4586	T4584	pobj	SEM,as
R3354	T4587	T4586	punct	±,SEM
R3355	T4588	T4582	punct	.,presented
R3356	T4590	T4591	det	A,test
R3357	T4591	T4598	nsubjpass	test,used
R3358	T4592	T4593	advmod	two,tailed
R3359	T4593	T4591	amod	tailed,test
R336	T580	T578	punct	),Williams
R3360	T4594	T4593	punct	-,tailed
R3361	T4595	T4591	poss	Student,test
R3362	T4596	T4595	case	's,Student
R3363	T4597	T4591	compound	t,test
R3364	T4599	T4598	auxpass	was,used
R3365	T4600	T4601	aux	to,calculate
R3366	T4601	T4598	advcl	calculate,used
R3367	T4602	T4603	compound	p,values
R3368	T4603	T4601	dobj	values,calculate
R3369	T4604	T4603	punct	-,values
R337	T581	T521	punct	.,have
R3370	T4605	T4598	punct	.,used
R3371	T4688	T4687	prep	of,Expression
R3372	T4689	T4690	amod	Endogenous,Transgene
R3373	T4690	T4688	pobj	Transgene,of
R3374	T4691	T4690	nmod	PPARδ,Transgene
R3375	T4692	T4691	cc	and,PPARδ
R3376	T4693	T4694	compound	VP16,PPARδ
R3377	T4694	T4691	conj	PPARδ,PPARδ
R3378	T4695	T4694	punct	-,PPARδ
R3379	T4696	T4687	prep	in,Expression
R338	T583	T584	amod	Adult,muscle
R3380	T4697	T4696	pobj	Muscle,in
R3381	T4699	T4700	punct	(,A
R3382	T4700	T4701	meta	A,hybridized
R3383	T4702	T4700	punct	),A
R3384	T4703	T4704	amod	Pooled,RNA
R3385	T4704	T4701	nsubjpass	RNA,hybridized
R3386	T4705	T4704	acl	isolated,RNA
R3387	T4706	T4705	prep	from,isolated
R3388	T4707	T4708	amod	various,muscles
R3389	T4708	T4706	pobj	muscles,from
R339	T584	T586	nsubj	muscle,shows
R3390	T4709	T4708	prep	of,muscles
R3391	T4710	T4711	nummod	five,mice
R3392	T4711	T4709	pobj	mice,of
R3393	T4712	T4713	amod	wild,type
R3394	T4713	T4711	nmod	type,mice
R3395	T4714	T4713	punct	-,type
R3396	T4715	T4711	amod	male,mice
R3397	T4716	T4711	compound	C57B6,mice
R3398	T4717	T4701	auxpass	was,hybridized
R3399	T4718	T4701	prep	with,hybridized
R34	T149	T148	amod	activated,form
R340	T585	T584	amod	skeletal,muscle
R3400	T4719	T4720	amod	indicated,probes
R3401	T4720	T4718	pobj	probes,with
R3402	T4721	T4701	punct	.,hybridized
R3403	T4724	T4723	punct	", ",EDL
R3404	T4725	T4726	compound	extensor,longus
R3405	T4726	T4723	appos	longus,EDL
R3406	T4727	T4726	compound	digitorum,longus
R3407	T4728	T4723	punct	;,EDL
R3408	T4729	T4723	appos	Gastro,EDL
R3409	T4730	T4729	punct	", ",Gastro
R341	T587	T586	dobj	plasticity,shows
R3410	T4731	T4729	appos	gastrocnemius,Gastro
R3411	T4732	T4723	punct	.,EDL
R3412	T4734	T4735	punct	(,B
R3413	T4735	T4736	meta	B,probed
R3414	T4737	T4735	punct	),B
R3415	T4738	T4739	amod	Pooled,proteins
R3416	T4739	T4736	nsubjpass	proteins,probed
R3417	T4740	T4739	amod	nuclear,proteins
R3418	T4741	T4742	punct	(,μg
R3419	T4742	T4739	parataxis	μg,proteins
R342	T588	T586	cc	and,shows
R3420	T4743	T4742	nummod	15,μg
R3421	T4744	T4745	punct	/,lane
R3422	T4745	T4742	prep	lane,μg
R3423	T4746	T4742	punct	),μg
R3424	T4747	T4739	acl	isolated,proteins
R3425	T4748	T4747	prep	from,isolated
R3426	T4749	T4748	pobj	muscles,from
R3427	T4750	T4749	prep	of,muscles
R3428	T4751	T4752	nummod	five,C57B6
R3429	T4752	T4750	pobj	C57B6,of
R343	T589	T590	aux	can,undergo
R3430	T4753	T4754	amod	wild,type
R3431	T4754	T4752	nmod	type,C57B6
R3432	T4755	T4754	punct	-,type
R3433	T4756	T4752	amod	male,C57B6
R3434	T4757	T4736	auxpass	were,probed
R3435	T4758	T4736	prep	with,probed
R3436	T4759	T4760	amod	anti-PPARδ,antibody
R3437	T4760	T4758	pobj	antibody,with
R3438	T4761	T4736	punct	.,probed
R3439	T4763	T4764	compound	RNA,polymerase
R344	T590	T586	conj	undergo,shows
R3440	T4764	T4765	nsubjpass	polymerase,shown
R3441	T4766	T4764	nummod	II,polymerase
R3442	T4767	T4764	punct	(,polymerase
R3443	T4768	T4764	appos	Pol,polymerase
R3444	T4769	T4768	nummod	II,Pol
R3445	T4770	T4764	punct	),polymerase
R3446	T4771	T4765	auxpass	is,shown
R3447	T4772	T4765	prep	as,shown
R3448	T4773	T4774	det	a,control
R3449	T4774	T4772	pobj	control,as
R345	T591	T590	dobj	conversion,undergo
R3450	T4775	T4774	compound	loading,control
R3451	T4776	T4765	punct	.,shown
R3452	T4778	T4779	punct	(,C
R3453	T4779	T4780	meta	C,Expression
R3454	T4781	T4779	punct	),C
R3455	T4782	T4780	prep	of,Expression
R3456	T4783	T4784	det	the,transgene
R3457	T4784	T4782	pobj	transgene,of
R3458	T4785	T4786	compound	VP16,PPARδ
R3459	T4786	T4784	compound	PPARδ,transgene
R346	T592	T591	prep	between,conversion
R3460	T4787	T4786	punct	-,PPARδ
R3461	T4788	T4780	prep	in,Expression
R3462	T4789	T4790	amod	various,tissues
R3463	T4790	T4788	pobj	tissues,in
R3464	T4791	T4780	punct	.,Expression
R3465	T4793	T4794	nummod	10,μg
R3466	T4794	T4795	nsubjpass	μg,hybridized
R3467	T4796	T4794	prep	of,μg
R3468	T4797	T4798	amod	total,RNA
R3469	T4798	T4796	pobj	RNA,of
R347	T593	T594	amod	different,types
R3470	T4799	T4798	prep	from,RNA
R3471	T4800	T4801	det	each,tissue
R3472	T4801	T4799	pobj	tissue,from
R3473	T4802	T4795	auxpass	was,hybridized
R3474	T4803	T4795	prep	with,hybridized
R3475	T4804	T4805	det	a,probe
R3476	T4805	T4803	pobj	probe,with
R3477	T4806	T4807	compound	VP16,cDNA
R3478	T4807	T4805	compound	cDNA,probe
R3479	T4808	T4795	punct	.,hybridized
R348	T594	T592	pobj	types,between
R3480	T4810	T4811	compound	Gastrocnemius,muscle
R3481	T4811	T4812	nsubjpass	muscle,used
R3482	T4813	T4812	auxpass	was,used
R3483	T4814	T4812	advmod	here,used
R3484	T4815	T4812	punct	.,used
R3485	T4817	T4818	punct	(,D
R3486	T4818	T4819	meta	D,probed
R3487	T4820	T4818	punct	),D
R3488	T4821	T4822	amod	Nuclear,proteins
R3489	T4822	T4819	nsubjpass	proteins,probed
R349	T595	T594	compound	fiber,types
R3490	T4823	T4824	punct	(,μg
R3491	T4824	T4822	parataxis	μg,proteins
R3492	T4825	T4824	nummod	15,μg
R3493	T4826	T4827	punct	/,lane
R3494	T4827	T4824	prep	lane,μg
R3495	T4828	T4824	punct	),μg
R3496	T4829	T4822	acl	isolated,proteins
R3497	T4830	T4829	prep	from,isolated
R3498	T4831	T4832	compound	gastrocnemius,muscle
R3499	T4832	T4830	pobj	muscle,from
R35	T150	T148	prep	of,form
R350	T596	T590	prep	in,undergo
R3500	T4833	T4832	prep	of,muscle
R3501	T4834	T4835	det	the,mice
R3502	T4835	T4833	pobj	mice,of
R3503	T4836	T4835	amod	transgenic,mice
R3504	T4837	T4838	punct	(,TG
R3505	T4838	T4835	parataxis	TG,mice
R3506	T4839	T4838	punct	),TG
R3507	T4840	T4835	cc	and,mice
R3508	T4841	T4842	det	the,littermates
R3509	T4842	T4835	conj	littermates,mice
R351	T597	T596	pobj	response,in
R3510	T4843	T4844	amod	wild,type
R3511	T4844	T4842	compound	type,littermates
R3512	T4845	T4844	punct	-,type
R3513	T4846	T4847	punct	(,WT
R3514	T4847	T4842	parataxis	WT,littermates
R3515	T4848	T4847	punct	),WT
R3516	T4849	T4819	auxpass	were,probed
R3517	T4850	T4819	prep	with,probed
R3518	T4851	T4852	amod	indicated,antibodies
R3519	T4852	T4850	pobj	antibodies,with
R352	T598	T597	prep	to,response
R3520	T4853	T4819	punct	.,probed
R3521	T4855	T4856	det	The,band
R3522	T4856	T4860	nsubj	band,serves
R3523	T4857	T4856	amod	upper,band
R3524	T4858	T4856	punct	", ",band
R3525	T4859	T4856	amod	nonspecific,band
R3526	T4861	T4862	dep	that,cross-reacted
R3527	T4862	T4856	relcl	cross-reacted,band
R3528	T4863	T4862	prep	with,cross-reacted
R3529	T4864	T4865	det	the,antibody
R353	T599	T600	compound	exercise,training
R3530	T4865	T4863	pobj	antibody,with
R3531	T4866	T4865	amod	anti-PPARδ,antibody
R3532	T4867	T4868	det	a,control
R3533	T4868	T4860	dobj	control,serves
R3534	T4869	T4868	compound	loading,control
R3535	T4870	T4860	punct	.,serves
R3536	T4894	T4895	amod	Increased,Fibers
R3537	T4896	T4895	amod	Oxidative,Fibers
R3538	T4897	T4895	nmod	Type,Fibers
R3539	T4898	T4897	nummod	I,Type
R354	T600	T598	pobj	training,to
R3540	T4899	T4895	prep	in,Fibers
R3541	T4900	T4901	det	the,Mice
R3542	T4901	T4899	pobj	Mice,in
R3543	T4902	T4901	amod	Transgenic,Mice
R3544	T4904	T4905	punct	(,A
R3545	T4905	T4906	meta	A,are
R3546	T4907	T4905	cc	and,A
R3547	T4908	T4905	conj	B,A
R3548	T4909	T4908	punct	),B
R3549	T4910	T4906	nsubj	Muscles,are
R355	T601	T600	cc	or,training
R3550	T4911	T4910	prep	in,Muscles
R3551	T4912	T4913	amod	transgenic,mice
R3552	T4913	T4911	pobj	mice,in
R3553	T4914	T4915	punct	(,TG
R3554	T4915	T4913	parataxis	TG,mice
R3555	T4916	T4915	punct	),TG
R3556	T4917	T4906	acomp	redder,are
R3557	T4918	T4917	prep	than,redder
R3558	T4919	T4918	pobj	those,than
R3559	T4920	T4919	prep	in,those
R356	T602	T600	conj	modulation,training
R3560	T4921	T4922	amod	wild,type
R3561	T4922	T4924	compound	type,mice
R3562	T4923	T4922	punct	-,type
R3563	T4924	T4920	pobj	mice,in
R3564	T4925	T4926	punct	(,WT
R3565	T4926	T4924	parataxis	WT,mice
R3566	T4927	T4926	punct	),WT
R3567	T4928	T4906	punct	.,are
R3568	T4930	T4931	punct	(,C
R3569	T4931	T4932	meta	C,staining
R357	T603	T602	prep	of,modulation
R3570	T4933	T4931	punct	),C
R3571	T4934	T4932	amod	Metachromatic,staining
R3572	T4935	T4932	prep	of,staining
R3573	T4936	T4937	det	the,muscle
R3574	T4937	T4935	pobj	muscle,of
R3575	T4938	T4937	nmod	type,muscle
R3576	T4939	T4938	nummod	II,type
R3577	T4940	T4937	compound	plantaris,muscle
R3578	T4941	T4932	punct	.,staining
R3579	T4943	T4944	nmod	Type,fibers
R358	T604	T605	compound	motoneuron,activity
R3580	T4944	T4946	nsubjpass	fibers,stained
R3581	T4945	T4943	nummod	I,Type
R3582	T4947	T4946	auxpass	are,stained
R3583	T4948	T4949	advmod	dark,blue
R3584	T4949	T4946	oprd	blue,stained
R3585	T4950	T4946	punct	.,stained
R3586	T5034	T5035	nsubj	Activation,Induces
R3587	T5036	T5034	prep	of,Activation
R3588	T5037	T5036	pobj	PPARδ,of
R3589	T5038	T5035	dobj	Genes,Induces
R359	T605	T603	pobj	activity,of
R3590	T5039	T5038	amod	Typical,Genes
R3591	T5040	T5039	prep	for,Typical
R3592	T5041	T5042	nmod	Type,Fibers
R3593	T5042	T5040	pobj	Fibers,for
R3594	T5043	T5041	nummod	I,Type
R3595	T5044	T5035	cc	and,Induces
R3596	T5045	T5035	conj	Promotes,Induces
R3597	T5046	T5047	amod	Mitochondrial,Biogenesis
R3598	T5047	T5045	dobj	Biogenesis,Promotes
R3599	T5049	T5050	punct	(,A
R36	T151	T152	compound	peroxisome,proliferator
R360	T606	T607	punct	(,Booth
R3600	T5050	T5051	meta	A,probed
R3601	T5052	T5050	punct	),A
R3602	T5053	T5054	amod	Total,RNA
R3603	T5054	T5051	nsubjpass	RNA,probed
R3604	T5055	T5056	punct	(,μg
R3605	T5056	T5054	parataxis	μg,RNA
R3606	T5057	T5056	nummod	10,μg
R3607	T5058	T5059	punct	/,lane
R3608	T5059	T5056	prep	lane,μg
R3609	T5060	T5056	punct	),μg
R361	T607	T590	meta	Booth,undergo
R3610	T5061	T5054	acl	prepared,RNA
R3611	T5062	T5061	prep	from,prepared
R3612	T5063	T5064	compound	gastrocnemius,muscle
R3613	T5064	T5062	pobj	muscle,from
R3614	T5065	T5064	prep	of,muscle
R3615	T5066	T5067	amod	transgenic,littermates
R3616	T5067	T5065	pobj	littermates,of
R3617	T5068	T5069	punct	(,TG
R3618	T5069	T5066	parataxis	TG,transgenic
R3619	T5070	T5069	punct	),TG
R362	T608	T607	cc	and,Booth
R3620	T5071	T5066	cc	and,transgenic
R3621	T5072	T5073	amod	wild,type
R3622	T5073	T5066	conj	type,transgenic
R3623	T5074	T5073	punct	-,type
R3624	T5075	T5076	punct	(,WT
R3625	T5076	T5073	parataxis	WT,type
R3626	T5077	T5076	punct	),WT
R3627	T5078	T5051	auxpass	was,probed
R3628	T5079	T5051	prep	with,probed
R3629	T5080	T5081	amod	indicated,probes
R363	T609	T607	conj	Thomason,Booth
R3630	T5081	T5079	pobj	probes,with
R3631	T5082	T5051	punct	.,probed
R3632	T5084	T5085	det	The,increase
R3633	T5085	T5087	nsubjpass	increase,shown
R3634	T5086	T5085	amod	fold,increase
R3635	T5088	T5085	prep	of,increase
R3636	T5089	T5088	pobj	induction,of
R3637	T5090	T5089	prep	of,induction
R3638	T5091	T5092	det	each,gene
R3639	T5092	T5090	pobj	gene,of
R364	T610	T609	nummod	1991,Thomason
R3640	T5093	T5087	auxpass	is,shown
R3641	T5094	T5087	punct	.,shown
R3642	T5096	T5097	punct	(,B
R3643	T5097	T5098	meta	B,digested
R3644	T5099	T5097	punct	),B
R3645	T5100	T5101	amod	Total,DNA
R3646	T5101	T5098	nsubjpass	DNA,digested
R3647	T5102	T5101	amod	genomic,DNA
R3648	T5103	T5104	punct	(,μg
R3649	T5104	T5101	parataxis	μg,DNA
R365	T611	T609	punct	", ",Thomason
R3650	T5105	T5104	nummod	10,μg
R3651	T5106	T5107	punct	/,lane
R3652	T5107	T5104	prep	lane,μg
R3653	T5108	T5104	punct	),μg
R3654	T5109	T5101	acl	prepared,DNA
R3655	T5110	T5109	prep	from,prepared
R3656	T5111	T5112	compound	gastrocnemius,muscle
R3657	T5112	T5110	pobj	muscle,from
R3658	T5113	T5098	auxpass	was,digested
R3659	T5114	T5098	prep	with,digested
R366	T612	T609	conj	Jarvis,Thomason
R3660	T5115	T5114	pobj	Nco1,with
R3661	T5116	T5098	cc	and,digested
R3662	T5117	T5098	conj	subjected,digested
R3663	T5118	T5117	prep	to,subjected
R3664	T5119	T5120	compound	Southern,analysis
R3665	T5120	T5118	pobj	analysis,to
R3666	T5121	T5117	prep	with,subjected
R3667	T5122	T5123	nmod	COXII,probes
R3668	T5123	T5121	pobj	probes,with
R3669	T5124	T5125	punct	(,encoded
R367	T613	T612	nmod	et,Jarvis
R3670	T5125	T5122	parataxis	encoded,COXII
R3671	T5126	T5127	amod	mitochondrial,genome
R3672	T5127	T5125	npadvmod	genome,encoded
R3673	T5128	T5125	punct	–,encoded
R3674	T5129	T5125	punct	),encoded
R3675	T5130	T5122	cc	and,COXII
R3676	T5131	T5122	conj	MCIP1,COXII
R3677	T5132	T5133	punct	(,encoded
R3678	T5133	T5131	parataxis	encoded,MCIP1
R3679	T5134	T5135	amod	nuclear,genome
R368	T614	T612	nmod	al.,Jarvis
R3680	T5135	T5133	npadvmod	genome,encoded
R3681	T5136	T5133	punct	–,encoded
R3682	T5137	T5133	punct	),encoded
R3683	T5138	T5123	compound	DNA,probes
R3684	T5139	T5098	punct	.,digested
R3685	T5141	T5142	punct	(,C
R3686	T5142	T5143	meta	C,collected
R3687	T5144	T5142	punct	),C
R3688	T5145	T5146	amod	Equal,amounts
R3689	T5146	T5143	nsubjpass	amounts,collected
R369	T615	T612	nummod	1996,Jarvis
R3690	T5147	T5146	prep	of,amounts
R3691	T5148	T5149	compound	gastrocnemius,muscle
R3692	T5149	T5147	pobj	muscle,of
R3693	T5150	T5143	auxpass	were,collected
R3694	T5151	T5143	prep	from,collected
R3695	T5152	T5153	preconj	both,mice
R3696	T5153	T5151	pobj	mice,from
R3697	T5154	T5153	amod	transgenic,mice
R3698	T5155	T5153	cc	and,mice
R3699	T5156	T5157	compound	control,littermates
R37	T152	T153	npadvmod	proliferator,activated
R370	T616	T612	punct	;,Jarvis
R3700	T5157	T5153	conj	littermates,mice
R3701	T5158	T5143	punct	.,collected
R3702	T5160	T5161	amod	Total,DNA
R3703	T5161	T5163	nsubjpass	DNA,isolated
R3704	T5162	T5161	amod	mitochondrial,DNA
R3705	T5164	T5163	auxpass	was,isolated
R3706	T5165	T5163	cc	and,isolated
R3707	T5166	T5163	conj	separated,isolated
R3708	T5167	T5166	prep	on,separated
R3709	T5168	T5169	nummod	1,%
R371	T617	T612	conj	Pette,Jarvis
R3710	T5169	T5170	compound	%,gel
R3711	T5170	T5167	pobj	gel,on
R3712	T5171	T5170	compound	agarose,gel
R3713	T5172	T5163	punct	.,isolated
R3714	T5174	T5175	det	The,abundance
R3715	T5175	T5177	nsubjpass	abundance,presented
R3716	T5176	T5175	amod	relative,abundance
R3717	T5178	T5175	prep	of,abundance
R3718	T5179	T5180	amod	mitochondrial,DNA
R3719	T5180	T5178	pobj	DNA,of
R372	T618	T617	nummod	1998,Pette
R3720	T5181	T5175	prep	in,abundance
R3721	T5182	T5183	amod	transgenic,mice
R3722	T5183	T5181	pobj	mice,in
R3723	T5184	T5182	cc	and,transgenic
R3724	T5185	T5186	amod	wild,type
R3725	T5186	T5182	conj	type,transgenic
R3726	T5187	T5186	punct	-,type
R3727	T5188	T5177	auxpass	is,presented
R3728	T5189	T5177	punct	.,presented
R3729	T5191	T5192	punct	(,D
R373	T619	T617	punct	;,Pette
R3730	T5192	T5193	meta	D,analysis
R3731	T5194	T5192	punct	),D
R3732	T5195	T5196	compound	Western,blot
R3733	T5196	T5193	compound	blot,analysis
R3734	T5197	T5193	prep	of,analysis
R3735	T5198	T5199	compound	muscle,fiber
R3736	T5199	T5200	compound	fiber,markers
R3737	T5200	T5197	pobj	markers,of
R3738	T5201	T5200	cc	and,markers
R3739	T5202	T5203	amod	mitochondrial,components
R374	T620	T617	conj	Olson,Pette
R3740	T5203	T5200	conj	components,markers
R3741	T5204	T5193	punct	.,analysis
R3742	T5206	T5207	det	Each,lane
R3743	T5207	T5208	nsubjpass	lane,loaded
R3744	T5209	T5208	auxpass	was,loaded
R3745	T5210	T5208	prep	with,loaded
R3746	T5211	T5212	nummod	80,μg
R3747	T5212	T5210	pobj	μg,with
R3748	T5213	T5212	prep	of,μg
R3749	T5214	T5215	amod	total,extracts
R375	T621	T620	cc	and,Olson
R3750	T5215	T5213	pobj	extracts,of
R3751	T5216	T5217	compound	gastrocnemius,muscle
R3752	T5217	T5215	compound	muscle,extracts
R3753	T5218	T5208	punct	.,loaded
R3754	T5220	T5221	punct	(,E
R3755	T5221	T5222	meta	E,treated
R3756	T5223	T5221	punct	),E
R3757	T5224	T5225	amod	Wild,type
R3758	T5225	T5227	compound	type,mice
R3759	T5226	T5225	punct	-,type
R376	T622	T620	conj	Williams,Olson
R3760	T5227	T5222	nsubjpass	mice,treated
R3761	T5228	T5227	compound	C57B6,mice
R3762	T5229	T5222	auxpass	were,treated
R3763	T5230	T5222	prep	with,treated
R3764	T5231	T5230	pobj	vehicle,with
R3765	T5232	T5231	cc	or,vehicle
R3766	T5233	T5234	compound	PPARδ,agonist
R3767	T5234	T5235	compound	agonist,GW501516
R3768	T5235	T5231	conj	GW501516,vehicle
R3769	T5236	T5222	prep	for,treated
R377	T623	T622	nummod	2000,Williams
R3770	T5237	T5238	nummod	10,d
R3771	T5238	T5236	pobj	d,for
R3772	T5239	T5222	punct	.,treated
R3773	T5241	T5242	amod	Total,RNA
R3774	T5242	T5243	nsubjpass	RNA,probed
R3775	T5244	T5245	punct	(,μg
R3776	T5245	T5242	parataxis	μg,RNA
R3777	T5246	T5245	nummod	10,μg
R3778	T5247	T5248	punct	/,lane
R3779	T5248	T5245	prep	lane,μg
R378	T624	T622	punct	;,Williams
R3780	T5249	T5245	punct	),μg
R3781	T5250	T5242	acl	prepared,RNA
R3782	T5251	T5250	prep	from,prepared
R3783	T5252	T5253	det	the,muscle
R3784	T5253	T5251	pobj	muscle,from
R3785	T5254	T5253	compound	gastrocnemius,muscle
R3786	T5255	T5243	auxpass	was,probed
R3787	T5256	T5243	prep	with,probed
R3788	T5257	T5258	amod	indicated,probes
R3789	T5258	T5256	pobj	probes,with
R379	T625	T622	conj	Hood,Williams
R3790	T5259	T5243	punct	.,probed
R3791	T5309	T5308	prep	to,Resistance
R3792	T5310	T5311	amod	High,Fat
R3793	T5311	T5313	npadvmod	Fat,Induced
R3794	T5312	T5311	punct	-,Fat
R3795	T5313	T5315	amod	Induced,Obesity
R3796	T5314	T5313	punct	-,Induced
R3797	T5315	T5309	pobj	Obesity,to
R3798	T5316	T5308	prep	in,Resistance
R3799	T5317	T5318	det	the,Mice
R38	T153	T155	amod	activated,receptor
R380	T626	T625	nummod	2001,Hood
R3800	T5318	T5316	pobj	Mice,in
R3801	T5319	T5318	amod	Transgenic,Mice
R3802	T5321	T5322	punct	(,A
R3803	T5322	T5323	meta	A,fed
R3804	T5324	T5322	punct	),A
R3805	T5325	T5326	nummod	Seven,week
R3806	T5326	T5328	npadvmod	week,old
R3807	T5327	T5326	punct	-,week
R3808	T5328	T5330	amod	old,littermates
R3809	T5329	T5328	punct	-,old
R381	T627	T625	punct	),Hood
R3810	T5330	T5323	nsubjpass	littermates,fed
R3811	T5331	T5330	amod	transgenic,littermates
R3812	T5332	T5333	punct	(,TG
R3813	T5333	T5331	parataxis	TG,transgenic
R3814	T5334	T5333	punct	),TG
R3815	T5335	T5331	cc	and,transgenic
R3816	T5336	T5337	amod	wild,type
R3817	T5337	T5331	conj	type,transgenic
R3818	T5338	T5337	punct	-,type
R3819	T5339	T5340	punct	(,WT
R382	T628	T586	punct	.,shows
R3820	T5340	T5337	parataxis	WT,type
R3821	T5341	T5340	punct	),WT
R3822	T5342	T5343	punct	(,6
R3823	T5343	T5330	parataxis	6,littermates
R3824	T5344	T5343	nsubj	n,6
R3825	T5345	T5343	punct	=,6
R3826	T5346	T5343	quantmod	5,6
R3827	T5347	T5343	punct	–,6
R3828	T5348	T5343	prep	for,6
R3829	T5349	T5350	det	each,group
R383	T630	T631	det	This,conversion
R3830	T5350	T5348	pobj	group,for
R3831	T5351	T5343	punct	),6
R3832	T5352	T5323	auxpass	were,fed
R3833	T5353	T5323	prep	with,fed
R3834	T5354	T5355	det	a,diet
R3835	T5355	T5353	pobj	diet,with
R3836	T5356	T5357	amod	high,fat
R3837	T5357	T5355	compound	fat,diet
R3838	T5358	T5357	punct	-,fat
R3839	T5359	T5323	prep	for,fed
R384	T631	T632	nsubj	conversion,is
R3840	T5360	T5361	nummod	97,d
R3841	T5361	T5359	pobj	d,for
R3842	T5362	T5323	punct	.,fed
R3843	T5364	T5365	amod	Left,panel
R3844	T5365	T5366	nsubj	panel,shows
R3845	T5367	T5368	amod	net,gain
R3846	T5368	T5366	dobj	gain,shows
R3847	T5369	T5370	compound	body,weight
R3848	T5370	T5368	compound	weight,gain
R3849	T5371	T5368	punct	", ",gain
R385	T633	T631	prep	of,conversion
R3850	T5372	T5373	dep	which,calculated
R3851	T5373	T5368	relcl	calculated,gain
R3852	T5374	T5373	auxpass	was,calculated
R3853	T5375	T5373	prep	for,calculated
R3854	T5376	T5377	amod	individual,mice
R3855	T5377	T5375	pobj	mice,for
R3856	T5378	T5373	cc	and,calculated
R3857	T5379	T5380	advmod	then,averaged
R3858	T5380	T5373	conj	averaged,calculated
R3859	T5381	T5366	punct	.,shows
R386	T634	T635	compound	muscle,fiber
R3860	T5383	T5384	amod	Right,panel
R3861	T5384	T5385	nsubj	panel,shows
R3862	T5386	T5387	det	the,weights
R3863	T5387	T5385	dobj	weights,shows
R3864	T5388	T5387	compound	body,weights
R3865	T5389	T5385	prep	before,shows
R3866	T5390	T5391	punct	(,Day
R3867	T5391	T5389	parataxis	Day,before
R3868	T5392	T5391	nummod	0,Day
R3869	T5393	T5391	punct	),Day
R387	T635	T633	pobj	fiber,of
R3870	T5394	T5389	cc	and,before
R3871	T5395	T5389	conj	after,before
R3872	T5396	T5397	punct	(,Day
R3873	T5397	T5395	parataxis	Day,after
R3874	T5398	T5397	nummod	97,Day
R3875	T5399	T5397	punct	),Day
R3876	T5400	T5401	amod	high,fat
R3877	T5401	T5403	compound	fat,feeding
R3878	T5402	T5401	punct	-,fat
R3879	T5403	T5395	pobj	feeding,after
R388	T636	T631	prep	from,conversion
R3880	T5404	T5385	punct	.,shows
R3881	T5406	T5407	punct	(,B
R3882	T5407	T5408	meta	B,Histology
R3883	T5409	T5407	punct	),B
R3884	T5410	T5408	prep	of,Histology
R3885	T5411	T5412	amod	inguinal,pad
R3886	T5412	T5410	pobj	pad,of
R3887	T5413	T5412	compound	fat,pad
R3888	T5414	T5408	prep	in,Histology
R3889	T5415	T5416	det	the,littermates
R389	T637	T638	compound	type,IIb
R3890	T5416	T5414	pobj	littermates,in
R3891	T5417	T5416	amod	transgenic,littermates
R3892	T5418	T5417	cc	and,transgenic
R3893	T5419	T5420	amod	wild,type
R3894	T5420	T5417	conj	type,transgenic
R3895	T5421	T5420	punct	-,type
R3896	T5422	T5408	prep	under,Histology
R3897	T5423	T5424	det	a,diet
R3898	T5424	T5422	pobj	diet,under
R3899	T5425	T5426	amod	high,fat
R39	T154	T153	punct	-,activated
R390	T638	T636	pobj	IIb,from
R3900	T5426	T5424	compound	fat,diet
R3901	T5427	T5426	punct	-,fat
R3902	T5428	T5408	prep	for,Histology
R3903	T5429	T5430	nummod	2,mo
R3904	T5430	T5428	pobj	mo,for
R3905	T5431	T5408	punct	.,Histology
R3906	T5433	T5434	punct	(,C
R3907	T5434	T5435	meta	C,content
R3908	T5436	T5434	cc	and,C
R3909	T5437	T5434	conj	D,C
R391	T639	T631	prep	to,conversion
R3910	T5438	T5437	punct	),D
R3911	T5439	T5435	amod	Intramuscular,content
R3912	T5440	T5435	compound	glycogen,content
R3913	T5441	T5442	punct	(,C
R3914	T5442	T5435	parataxis	C,content
R3915	T5443	T5442	punct	),C
R3916	T5444	T5435	cc	and,content
R3917	T5445	T5446	compound	triglyceride,content
R3918	T5446	T5435	conj	content,content
R3919	T5447	T5448	punct	(,D
R392	T640	T641	compound	type,IIa
R3920	T5448	T5446	parataxis	D,content
R3921	T5449	T5448	punct	),D
R3922	T5450	T5435	prep	of,content
R3923	T5451	T5450	pobj	mice,of
R3924	T5452	T5451	prep	in,mice
R3925	T5453	T5452	punct	(,in
R3926	T5454	T5452	pobj	A,in
R3927	T5455	T5452	punct	),in
R3928	T5456	T5435	prep	after,content
R3929	T5457	T5458	amod	high,fat
R393	T641	T639	pobj	IIa,to
R3930	T5458	T5460	compound	fat,feeding
R3931	T5459	T5458	punct	-,fat
R3932	T5460	T5456	pobj	feeding,after
R3933	T5461	T5462	punct	(,6
R3934	T5462	T5435	parataxis	6,content
R3935	T5463	T5462	nsubj	n,6
R3936	T5464	T5462	punct	=,6
R3937	T5465	T5462	punct	),6
R3938	T5466	T5435	punct	.,content
R3939	T5468	T5469	punct	(,E
R394	T642	T641	cc	and,IIa
R3940	T5469	T5470	meta	E,test
R3941	T5471	T5469	punct	),E
R3942	T5472	T5473	compound	Glucose,tolerance
R3943	T5473	T5470	compound	tolerance,test
R3944	T5474	T5470	punct	.,test
R3945	T5476	T5477	nsubjpass	Mice,fasted
R3946	T5478	T5476	prep	in,Mice
R3947	T5479	T5478	punct	(,in
R3948	T5480	T5478	pobj	A,in
R3949	T5481	T5478	punct	),in
R395	T643	T641	conj	type,IIa
R3950	T5482	T5476	prep	after,Mice
R3951	T5483	T5484	amod	high,fat
R3952	T5484	T5486	compound	fat,feeding
R3953	T5485	T5484	punct	-,fat
R3954	T5486	T5482	pobj	feeding,after
R3955	T5487	T5477	auxpass	were,fasted
R3956	T5488	T5477	prep	for,fasted
R3957	T5489	T5490	nummod	6,h
R3958	T5490	T5488	pobj	h,for
R3959	T5491	T5477	cc	and,fasted
R396	T644	T643	nummod	I,type
R3960	T5492	T5493	advmod	then,injected
R3961	T5493	T5477	conj	injected,fasted
R3962	T5494	T5493	prep	with,injected
R3963	T5495	T5494	pobj	glucose,with
R3964	T5496	T5493	prep	at,injected
R3965	T5497	T5498	det	a,concentration
R3966	T5498	T5496	pobj	concentration,at
R3967	T5499	T5498	prep	of,concentration
R3968	T5500	T5499	pobj	1g,of
R3969	T5501	T5502	punct	/,weight
R397	T645	T632	acomp	likely,is
R3970	T5502	T5500	prep	weight,1g
R3971	T5503	T5502	compound	kg,weight
R3972	T5504	T5502	compound	body,weight
R3973	T5505	T5477	punct	.,fasted
R3974	T5507	T5508	advmod	Then,measured
R3975	T5509	T5510	compound	blood,glucose
R3976	T5510	T5511	compound	glucose,levels
R3977	T5511	T5508	nsubjpass	levels,measured
R3978	T5512	T5508	auxpass	were,measured
R3979	T5513	T5508	advmod	periodically,measured
R398	T646	T647	aux	to,mediated
R3980	T5514	T5508	prep	over,measured
R3981	T5515	T5516	nummod	2,h
R3982	T5516	T5514	pobj	h,over
R3983	T5517	T5518	punct	(,6
R3984	T5518	T5508	parataxis	6,measured
R3985	T5519	T5518	nsubj	n,6
R3986	T5520	T5518	punct	=,6
R3987	T5521	T5518	punct	),6
R3988	T5522	T5508	punct	.,measured
R3989	T5573	T5574	compound	PPARδ,Agonists
R399	T647	T645	xcomp	mediated,likely
R3990	T5574	T5575	nsubj	Agonists,Counteract
R3991	T5576	T5575	dobj	Obesity,Counteract
R3992	T5577	T5576	acl	Induced,Obesity
R3993	T5578	T5577	agent	by,Induced
R3994	T5579	T5580	amod	High,Fat
R3995	T5580	T5582	compound	Fat,Diet
R3996	T5581	T5580	punct	-,Fat
R3997	T5582	T5578	pobj	Diet,by
R3998	T5584	T5585	punct	(,A
R3999	T5585	T5586	meta	A,fed
R4	T117	T118	det	the,engineering
R40	T155	T150	pobj	receptor,of
R400	T648	T647	auxpass	be,mediated
R4000	T5587	T5585	punct	),A
R4001	T5588	T5589	nummod	Eleven,week
R4002	T5589	T5591	npadvmod	week,old
R4003	T5590	T5589	punct	-,week
R4004	T5591	T5593	amod	old,mice
R4005	T5592	T5591	punct	-,old
R4006	T5593	T5586	nsubjpass	mice,fed
R4007	T5594	T5595	amod	wild,type
R4008	T5595	T5593	compound	type,mice
R4009	T5596	T5595	punct	-,type
R401	T649	T647	agent	by,mediated
R4010	T5597	T5593	compound	C57B6,mice
R4011	T5598	T5586	auxpass	were,fed
R4012	T5599	T5600	det	a,diet
R4013	T5600	T5586	dobj	diet,fed
R4014	T5601	T5602	amod	high,fat
R4015	T5602	T5600	compound	fat,diet
R4016	T5603	T5602	punct	-,fat
R4017	T5604	T5586	prep	in,fed
R4018	T5605	T5604	pobj	combination,in
R4019	T5606	T5605	prep	with,combination
R402	T650	T651	det	a,pathway
R4020	T5607	T5606	pobj	vehicle,with
R4021	T5608	T5607	cc	or,vehicle
R4022	T5609	T5607	conj	GW501516,vehicle
R4023	T5610	T5586	prep	for,fed
R4024	T5611	T5612	nummod	57,d
R4025	T5612	T5610	pobj	d,for
R4026	T5613	T5586	punct	.,fed
R4027	T5615	T5616	amod	Total,RNA
R4028	T5616	T5617	nsubjpass	RNA,probed
R4029	T5618	T5619	punct	(,μg
R403	T651	T649	pobj	pathway,by
R4030	T5619	T5616	parataxis	μg,RNA
R4031	T5620	T5619	nummod	10,μg
R4032	T5621	T5622	punct	/,lane
R4033	T5622	T5619	prep	lane,μg
R4034	T5623	T5619	punct	),μg
R4035	T5624	T5616	acl	prepared,RNA
R4036	T5625	T5624	prep	from,prepared
R4037	T5626	T5627	det	the,muscle
R4038	T5627	T5625	pobj	muscle,from
R4039	T5628	T5627	compound	gastrocnemius,muscle
R404	T652	T651	compound	calcium,pathway
R4040	T5629	T5617	auxpass	was,probed
R4041	T5630	T5617	prep	with,probed
R4042	T5631	T5632	amod	indicated,probes
R4043	T5632	T5630	pobj	probes,with
R4044	T5633	T5617	punct	.,probed
R4045	T5635	T5636	punct	(,B
R4046	T5636	T5637	meta	B,calculated
R4047	T5638	T5636	punct	),B
R4048	T5639	T5640	amod	Net,gain
R4049	T5640	T5637	nsubjpass	gain,calculated
R405	T653	T651	compound	signaling,pathway
R4050	T5641	T5642	compound	body,weight
R4051	T5642	T5640	compound	weight,gain
R4052	T5643	T5640	prep	for,gain
R4053	T5644	T5643	pobj	mice,for
R4054	T5645	T5644	prep	in,mice
R4055	T5646	T5645	punct	(,in
R4056	T5647	T5645	pobj	A,in
R4057	T5648	T5644	punct	),mice
R4058	T5649	T5640	prep	after,gain
R4059	T5650	T5649	pobj	treatment,after
R406	T654	T655	dep	that,involves
R4060	T5651	T5637	auxpass	was,calculated
R4061	T5652	T5637	prep	for,calculated
R4062	T5653	T5654	amod	individual,mice
R4063	T5654	T5652	pobj	mice,for
R4064	T5655	T5637	cc	and,calculated
R4065	T5656	T5637	conj	averaged,calculated
R4066	T5657	T5637	punct	.,calculated
R4067	T5659	T5660	amod	Initial,weights
R4068	T5660	T5662	nsubj	weights,were
R4069	T5661	T5660	compound	body,weights
R407	T655	T651	relcl	involves,pathway
R4070	T5663	T5664	quantmod	28.54,1.04
R4071	T5664	T5666	nummod	1.04,g
R4072	T5665	T5664	punct	±,1.04
R4073	T5666	T5662	attr	g,were
R4074	T5667	T5666	prep	for,g
R4075	T5668	T5669	compound	vehicle,group
R4076	T5669	T5667	pobj	group,for
R4077	T5670	T5671	punct	(,5
R4078	T5671	T5666	parataxis	5,g
R4079	T5672	T5671	nsubj	n,5
R408	T656	T655	dobj	calcineurin,involves
R4080	T5673	T5671	punct	=,5
R4081	T5674	T5671	punct	),5
R4082	T5675	T5666	cc	and,g
R4083	T5676	T5677	quantmod	28.86,0.80
R4084	T5677	T5679	nummod	0.80,g
R4085	T5678	T5677	punct	±,0.80
R4086	T5679	T5666	conj	g,g
R4087	T5680	T5679	prep	for,g
R4088	T5681	T5682	compound	GW501516,group
R4089	T5682	T5680	pobj	group,for
R409	T657	T656	punct	", ",calcineurin
R4090	T5683	T5684	punct	(,5
R4091	T5684	T5679	parataxis	5,g
R4092	T5685	T5684	nsubj	n,5
R4093	T5686	T5684	punct	=,5
R4094	T5687	T5684	punct	),5
R4095	T5688	T5662	punct	.,were
R4096	T5690	T5691	punct	(,C
R4097	T5691	T5692	meta	C,weights
R4098	T5693	T5691	punct	),C
R4099	T5694	T5692	amod	Various,weights
R41	T156	T155	punct	δ,receptor
R410	T658	T659	npadvmod	calmodulin,dependent
R4100	T5695	T5692	compound	tissue,weights
R4101	T5696	T5692	prep	for,weights
R4102	T5697	T5696	pobj	mice,for
R4103	T5698	T5697	prep	in,mice
R4104	T5699	T5698	punct	(,in
R4105	T5700	T5698	pobj	A,in
R4106	T5701	T5698	punct	),in
R4107	T5702	T5692	prep	after,weights
R4108	T5703	T5702	pobj	treatment,after
R4109	T5704	T5692	punct	.,weights
R411	T659	T661	amod	dependent,kinase
R4110	T5707	T5706	punct	", ",ifat
R4111	T5708	T5709	amod	inguinal,fat
R4112	T5709	T5706	appos	fat,ifat
R4113	T5710	T5706	punct	;,ifat
R4114	T5711	T5706	appos	rdfat,ifat
R4115	T5712	T5711	punct	", ",rdfat
R4116	T5713	T5714	amod	reproductive,fat
R4117	T5714	T5711	appos	fat,rdfat
R4118	T5715	T5706	punct	;,ifat
R4119	T5716	T5706	appos	retrofat,ifat
R412	T660	T659	punct	-,dependent
R4120	T5717	T5716	punct	", ",retrofat
R4121	T5718	T5719	amod	retroperitoneal,fat
R4122	T5719	T5716	appos	fat,retrofat
R4123	T5720	T5706	punct	.,ifat
R4124	T5722	T5723	punct	(,D
R4125	T5723	T5724	meta	D,test
R4126	T5725	T5723	punct	),D
R4127	T5726	T5727	compound	Glucose,tolerance
R4128	T5727	T5724	compound	tolerance,test
R4129	T5728	T5724	punct	.,test
R413	T661	T656	conj	kinase,calcineurin
R4130	T5730	T5731	nsubjpass	Mice,fasted
R4131	T5732	T5730	prep	in,Mice
R4132	T5733	T5732	punct	(,in
R4133	T5734	T5732	pobj	A,in
R4134	T5735	T5730	punct	),Mice
R4135	T5736	T5730	prep	after,Mice
R4136	T5737	T5736	pobj	treatment,after
R4137	T5738	T5731	auxpass	were,fasted
R4138	T5739	T5731	prep	for,fasted
R4139	T5740	T5741	nummod	6,h
R414	T662	T661	punct	", ",kinase
R4140	T5741	T5739	pobj	h,for
R4141	T5742	T5731	cc	and,fasted
R4142	T5743	T5744	advmod	then,injected
R4143	T5744	T5731	conj	injected,fasted
R4144	T5745	T5744	prep	with,injected
R4145	T5746	T5745	pobj	glucose,with
R4146	T5747	T5746	prep	at,glucose
R4147	T5748	T5749	det	a,concentration
R4148	T5749	T5747	pobj	concentration,at
R4149	T5750	T5749	prep	of,concentration
R415	T663	T661	cc	and,kinase
R4150	T5751	T5750	pobj	1g,of
R4151	T5752	T5753	punct	/,weight
R4152	T5753	T5751	prep	weight,1g
R4153	T5754	T5753	compound	kg,weight
R4154	T5755	T5753	compound	body,weight
R4155	T5756	T5731	punct	.,fasted
R4156	T5758	T5759	compound	Blood,glucose
R4157	T5759	T5760	compound	glucose,levels
R4158	T5760	T5761	nsubjpass	levels,measured
R4159	T5762	T5761	auxpass	were,measured
R416	T664	T665	det	the,cofactor
R4160	T5763	T5761	advmod	then,measured
R4161	T5764	T5761	advmod	periodically,measured
R4162	T5765	T5761	prep	over,measured
R4163	T5766	T5767	nummod	2,h
R4164	T5767	T5765	pobj	h,over
R4165	T5768	T5761	punct	.,measured
R4166	T5797	T5798	nsubj	PPARδ,Regulates
R4167	T5799	T5800	compound	Exercise,Endurance
R4168	T5800	T5798	dobj	Endurance,Regulates
R4169	T5802	T5803	punct	(,A
R417	T665	T661	conj	cofactor,kinase
R4170	T5803	T5804	meta	A,performance
R4171	T5805	T5803	punct	),A
R4172	T5806	T5804	amod	Enhanced,performance
R4173	T5807	T5804	compound	exercise,performance
R4174	T5808	T5804	prep	in,performance
R4175	T5809	T5810	det	the,mice
R4176	T5810	T5808	pobj	mice,in
R4177	T5811	T5810	amod	transgenic,mice
R4178	T5812	T5804	punct	.,performance
R4179	T5814	T5815	nummod	Fourteen,week
R418	T666	T665	amod	transcriptional,cofactor
R4180	T5815	T5817	npadvmod	week,old
R4181	T5816	T5815	punct	-,week
R4182	T5817	T5819	amod	old,littermates
R4183	T5818	T5817	punct	-,old
R4184	T5819	T5826	nsubjpass	littermates,subjected
R4185	T5820	T5819	amod	male,littermates
R4186	T5821	T5819	amod	transgenic,littermates
R4187	T5822	T5821	cc	and,transgenic
R4188	T5823	T5824	amod	wild,type
R4189	T5824	T5821	conj	type,transgenic
R419	T667	T668	compound	Peroxisome,proliferator
R4190	T5825	T5824	punct	-,type
R4191	T5827	T5819	prep	with,littermates
R4192	T5828	T5829	amod	similar,weights
R4193	T5829	T5827	pobj	weights,with
R4194	T5830	T5829	compound	body,weights
R4195	T5831	T5832	punct	(,4
R4196	T5832	T5819	parataxis	4,littermates
R4197	T5833	T5832	nsubj	n,4
R4198	T5834	T5832	punct	=,4
R4199	T5835	T5832	prep	for,4
R42	T157	T155	punct	(,receptor
R420	T668	T669	npadvmod	proliferator,activated
R4200	T5836	T5837	det	each,group
R4201	T5837	T5835	pobj	group,for
R4202	T5838	T5832	punct	),4
R4203	T5839	T5826	auxpass	were,subjected
R4204	T5840	T5826	prep	to,subjected
R4205	T5841	T5842	det	a,test
R4206	T5842	T5840	pobj	test,to
R4207	T5843	T5844	amod	forced,exercise
R4208	T5844	T5842	compound	exercise,test
R4209	T5845	T5844	compound	treadmill,exercise
R421	T669	T671	amod	activated,receptor
R4210	T5846	T5826	punct	.,subjected
R4211	T5848	T5849	punct	(,B
R4212	T5849	T5850	meta	B,performance
R4213	T5851	T5849	punct	),B
R4214	T5852	T5850	amod	Compromised,performance
R4215	T5853	T5850	compound	exercise,performance
R4216	T5854	T5850	prep	in,performance
R4217	T5855	T5856	npadvmod	PPARδ,null
R4218	T5856	T5858	amod	null,mice
R4219	T5857	T5856	punct	-,null
R422	T670	T669	punct	-,activated
R4220	T5858	T5854	pobj	mice,in
R4221	T5859	T5850	punct	.,performance
R4222	T5861	T5862	nummod	Two,month
R4223	T5862	T5864	npadvmod	month,old
R4224	T5863	T5862	punct	-,month
R4225	T5864	T5866	amod	old,mice
R4226	T5865	T5864	punct	-,old
R4227	T5866	T5871	nsubjpass	mice,subjected
R4228	T5867	T5866	amod	male,mice
R4229	T5868	T5869	npadvmod	PPARδ,null
R423	T671	T672	compound	receptor,coactivator
R4230	T5869	T5866	amod	null,mice
R4231	T5870	T5869	punct	-,null
R4232	T5872	T5866	cc	and,mice
R4233	T5873	T5874	amod	wild,type
R4234	T5874	T5876	compound	type,controls
R4235	T5875	T5874	punct	-,type
R4236	T5876	T5866	conj	controls,mice
R4237	T5877	T5866	prep	with,mice
R4238	T5878	T5879	amod	similar,weights
R4239	T5879	T5877	pobj	weights,with
R424	T672	T665	appos	coactivator,cofactor
R4240	T5880	T5879	compound	body,weights
R4241	T5881	T5882	punct	(,6
R4242	T5882	T5866	parataxis	6,mice
R4243	T5883	T5882	nsubj	n,6
R4244	T5884	T5882	punct	=,6
R4245	T5885	T5882	prep	for,6
R4246	T5886	T5887	det	each,group
R4247	T5887	T5885	pobj	group,for
R4248	T5888	T5882	punct	),6
R4249	T5889	T5871	auxpass	were,subjected
R425	T673	T672	punct	-,coactivator
R4250	T5890	T5871	prep	to,subjected
R4251	T5891	T5892	det	a,test
R4252	T5892	T5890	pobj	test,to
R4253	T5893	T5894	amod	forced,exercise
R4254	T5894	T5892	compound	exercise,test
R4255	T5895	T5894	compound	treadmill,exercise
R4256	T5896	T5871	punct	.,subjected
R4257	T5898	T5899	punct	(,C
R4258	T5899	T5900	meta	C,Functions
R4259	T5901	T5899	punct	),C
R426	T674	T672	compound	gamma,coactivator
R4260	T5902	T5900	prep	of,Functions
R4261	T5903	T5902	pobj	PPARδ,of
R4262	T5904	T5900	prep	in,Functions
R4263	T5905	T5906	amod	skeletal,muscle
R4264	T5906	T5904	pobj	muscle,in
R4265	T5907	T5900	punct	.,Functions
R427	T675	T672	nummod	1α,coactivator
R428	T676	T672	punct	(,coactivator
R429	T677	T678	compound	PGC,1α
R43	T158	T155	appos	PPARδ,receptor
R430	T678	T672	appos	1α,coactivator
R431	T679	T678	punct	-,1α
R432	T680	T672	punct	),coactivator
R433	T681	T682	punct	(,Naya
R434	T682	T655	meta	Naya,involves
R435	T683	T682	nmod	et,Naya
R436	T684	T682	nmod	al.,Naya
R437	T685	T682	nummod	2000,Naya
R438	T686	T682	punct	;,Naya
R439	T687	T682	conj	Olson,Naya
R44	T159	T155	punct	),receptor
R440	T688	T687	cc	and,Olson
R441	T689	T687	conj	Williams,Olson
R442	T690	T689	nummod	2000,Williams
R443	T691	T689	punct	;,Williams
R444	T692	T689	conj	Lin,Williams
R445	T693	T692	nmod	et,Lin
R446	T694	T692	nmod	al.,Lin
R447	T695	T692	nummod	2002,Lin
R448	T696	T692	punct	;,Lin
R449	T697	T692	conj	Wu,Lin
R45	T160	T148	prep	in,form
R450	T698	T697	nmod	et,Wu
R451	T699	T697	nmod	al.,Wu
R452	T700	T697	nummod	2002,Wu
R453	T701	T697	punct	),Wu
R454	T702	T632	punct	.,is
R455	T704	T705	advmod	However,remain
R456	T706	T705	punct	", ",remain
R457	T707	T708	det	the,factors
R458	T708	T705	nsubj	factors,remain
R459	T709	T708	amod	targeted,factors
R46	T161	T162	amod	skeletal,muscle
R460	T710	T708	amod	transcriptional,factors
R461	T711	T712	advmod	directly,responsible
R462	T712	T708	amod	responsible,factors
R463	T713	T712	prep	for,responsible
R464	T714	T713	pcomp	reprogramming,for
R465	T715	T716	det	the,genes
R466	T716	T714	dobj	genes,reprogramming
R467	T717	T718	npadvmod	fiber,specific
R468	T718	T716	amod	specific,genes
R469	T719	T718	punct	-,specific
R47	T162	T160	pobj	muscle,in
R470	T720	T716	amod	contractile,genes
R471	T721	T720	cc	and,contractile
R472	T722	T720	conj	metabolic,contractile
R473	T723	T724	aux	to,identified
R474	T724	T705	xcomp	identified,remain
R475	T725	T724	auxpass	be,identified
R476	T726	T705	punct	.,remain
R477	T728	T729	compound	Muscle,specification
R478	T729	T731	nsubj	specification,appears
R479	T730	T729	compound	fiber,specification
R48	T163	T148	punct	", ",form
R480	T732	T733	aux	to,associated
R481	T733	T731	xcomp	associated,appears
R482	T734	T733	auxpass	be,associated
R483	T735	T733	prep	with,associated
R484	T736	T735	pobj	obesity,with
R485	T737	T736	cc	and,obesity
R486	T738	T736	conj	diabetes,obesity
R487	T739	T731	punct	.,appears
R488	T741	T742	prep	For,possess
R489	T743	T741	pobj	instance,For
R49	T164	T165	dep	which,induces
R490	T744	T742	punct	", ",possess
R491	T745	T742	nsubj	rodents,possess
R492	T746	T747	dep	that,gain
R493	T747	T745	relcl	gain,rodents
R494	T748	T749	det	the,weight
R495	T749	T747	dobj	weight,gain
R496	T750	T749	amod	most,weight
R497	T751	T747	prep	on,gain
R498	T752	T753	amod	high,fat
R499	T753	T755	compound	fat,diets
R5	T118	T116	dobj	engineering,describe
R50	T192	T193	nmod	type,fiber
R500	T754	T753	punct	-,fat
R501	T755	T751	pobj	diets,on
R502	T756	T757	amod	fewer,fibers
R503	T757	T742	dobj	fibers,possess
R504	T758	T757	nmod	type,fibers
R505	T759	T758	nummod	I,type
R506	T760	T761	punct	(,Abou
R507	T761	T742	meta	Abou,possess
R508	T762	T761	nmod	et,Abou
R509	T763	T761	nmod	al.,Abou
R51	T193	T190	compound	fiber,profile
R510	T764	T761	nummod	1992,Abou
R511	T765	T761	punct	),Abou
R512	T766	T742	punct	.,possess
R513	T768	T769	prep	In,observed
R514	T770	T771	amod	obese,patients
R515	T771	T768	pobj	patients,In
R516	T772	T769	punct	", ",observed
R517	T773	T774	amod	skeletal,muscle
R518	T774	T769	nsubjpass	muscle,observed
R519	T775	T769	aux	has,observed
R52	T194	T192	nummod	I,type
R520	T776	T769	auxpass	been,observed
R521	T777	T778	aux	to,have
R522	T778	T769	xcomp	have,observed
R523	T779	T780	amod	reduced,capacity
R524	T780	T778	dobj	capacity,have
R525	T781	T780	amod	oxidative,capacity
R526	T782	T780	punct	", ",capacity
R527	T783	T784	amod	increased,capacity
R528	T784	T780	conj	capacity,capacity
R529	T785	T784	amod	glycolytic,capacity
R53	T195	T196	compound	gene,expression
R530	T786	T784	punct	", ",capacity
R531	T787	T784	cc	and,capacity
R532	T788	T789	det	a,percentage
R533	T789	T784	conj	percentage,capacity
R534	T790	T789	amod	decreased,percentage
R535	T791	T789	prep	of,percentage
R536	T792	T793	nmod	type,fibers
R537	T793	T791	pobj	fibers,of
R538	T794	T792	nummod	I,type
R539	T795	T796	punct	(,Hickey
R54	T196	T190	compound	expression,profile
R540	T796	T769	meta	Hickey,observed
R541	T797	T796	nmod	et,Hickey
R542	T798	T796	nmod	al.,Hickey
R543	T799	T796	nummod	1995,Hickey
R544	T800	T796	punct	;,Hickey
R545	T801	T796	nmod	Tanner,Hickey
R546	T802	T796	nmod	et,Hickey
R547	T803	T796	nmod	al.,Hickey
R548	T804	T796	nummod	2002,Hickey
R549	T805	T796	punct	),Hickey
R55	T197	T180	prep	in,elicits
R550	T806	T769	punct	.,observed
R551	T808	T809	amod	Similar,observations
R552	T809	T810	nsubjpass	observations,made
R553	T811	T810	aux	have,made
R554	T812	T810	auxpass	been,made
R555	T813	T810	prep	in,made
R556	T814	T815	npadvmod	type,diabetic
R557	T815	T817	amod	diabetic,patients
R558	T816	T814	nummod	2,type
R559	T817	T813	pobj	patients,in
R56	T198	T197	pobj	muscle,in
R560	T818	T819	punct	(,Lillioja
R561	T819	T810	meta	Lillioja,made
R562	T820	T819	nmod	et,Lillioja
R563	T821	T819	nmod	al.,Lillioja
R564	T822	T819	nummod	1987,Lillioja
R565	T823	T819	punct	;,Lillioja
R566	T824	T819	nmod	Hickey,Lillioja
R567	T825	T819	nmod	et,Lillioja
R568	T826	T819	nmod	al.,Lillioja
R569	T827	T819	nummod	1995,Lillioja
R57	T199	T180	punct	.,elicits
R570	T828	T819	punct	),Lillioja
R571	T829	T810	punct	.,made
R572	T831	T832	advmod	Recently,shown
R573	T833	T832	punct	", ",shown
R574	T834	T832	nsubjpass	it,shown
R575	T835	T832	aux	has,shown
R576	T836	T832	auxpass	been,shown
R577	T837	T838	mark	that,lead
R578	T838	T832	ccomp	lead,shown
R579	T839	T840	amod	increasing,fibers
R58	T201	T202	advmod	Moreover,confer
R580	T840	T838	nsubj	fibers,lead
R581	T841	T840	amod	oxidative,fibers
R582	T842	T838	aux	can,lead
R583	T843	T838	prep	to,lead
R584	T844	T845	amod	improved,action
R585	T845	T843	pobj	action,to
R586	T846	T845	compound	insulin,action
R587	T847	T845	cc	and,action
R588	T848	T849	amod	reduced,size
R589	T849	T845	conj	size,action
R59	T203	T202	punct	", ",confer
R590	T850	T849	compound	adipocyte,size
R591	T851	T852	punct	(,Luquet
R592	T852	T832	meta	Luquet,shown
R593	T853	T852	nmod	et,Luquet
R594	T854	T852	nmod	al.,Luquet
R595	T855	T852	nummod	2003,Luquet
R596	T856	T852	punct	;,Luquet
R597	T857	T852	nmod	Ryder,Luquet
R598	T858	T852	nmod	et,Luquet
R599	T859	T852	nmod	al.,Luquet
R6	T119	T118	prep	of,engineering
R60	T204	T205	det	these,fibers
R600	T860	T852	nummod	2003,Luquet
R601	T861	T852	punct	),Luquet
R602	T862	T832	punct	.,shown
R603	T864	T865	nsubj	We,established
R604	T866	T865	aux	have,established
R605	T867	T865	advmod	previously,established
R606	T868	T869	mark	that,is
R607	T869	T865	ccomp	is,established
R608	T870	T871	compound	peroxisome,proliferator
R609	T871	T872	npadvmod	proliferator,activated
R61	T205	T202	nsubj	fibers,confer
R610	T872	T874	amod	activated,receptor
R611	T873	T872	punct	-,activated
R612	T874	T869	nsubj	receptor,is
R613	T875	T874	punct	(,receptor
R614	T876	T874	appos	PPAR,receptor
R615	T877	T874	punct	),receptor
R616	T878	T874	punct	δ,receptor
R617	T879	T880	det	a,regulator
R618	T880	T869	attr	regulator,is
R619	T881	T880	amod	major,regulator
R62	T206	T207	advmod	genetically,generated
R620	T882	T880	amod	transcriptional,regulator
R621	T883	T880	prep	of,regulator
R622	T884	T885	compound	fat,burning
R623	T885	T883	pobj	burning,of
R624	T886	T869	prep	in,is
R625	T887	T888	compound	adipose,tissue
R626	T888	T886	pobj	tissue,in
R627	T889	T869	prep	through,is
R628	T890	T889	pobj	activation,through
R629	T891	T890	prep	of,activation
R63	T207	T205	amod	generated,fibers
R630	T892	T891	pobj	enzymes,of
R631	T893	T892	acl	associated,enzymes
R632	T894	T893	prep	with,associated
R633	T895	T896	amod	long,chain
R634	T896	T898	nmod	chain,oxidation
R635	T897	T896	punct	-,chain
R636	T898	T894	pobj	oxidation,with
R637	T899	T900	amod	fatty,acid
R638	T900	T898	compound	acid,oxidation
R639	T901	T900	punct	-,acid
R64	T208	T202	dobj	resistance,confer
R640	T902	T898	compound	β,oxidation
R641	T903	T898	punct	-,oxidation
R642	T904	T905	punct	(,Wang
R643	T905	T865	meta	Wang,established
R644	T906	T905	nmod	et,Wang
R645	T907	T905	nmod	al.,Wang
R646	T908	T905	nummod	2003,Wang
R647	T909	T905	punct	),Wang
R648	T910	T865	punct	.,established
R649	T912	T913	mark	Although,is
R65	T209	T208	prep	to,resistance
R650	T913	T915	advcl	is,determined
R651	T914	T913	nsubj	PPARδ,is
R652	T916	T917	det	the,isoform
R653	T917	T913	attr	isoform,is
R654	T918	T917	amod	predominant,isoform
R655	T919	T917	compound	PPAR,isoform
R656	T920	T917	amod	present,isoform
R657	T921	T920	prep	in,present
R658	T922	T923	amod	skeletal,muscle
R659	T923	T921	pobj	muscle,in
R66	T210	T209	pobj	obesity,to
R660	T924	T915	punct	", ",determined
R661	T925	T926	poss	its,function
R662	T926	T915	nsubjpass	function,determined
R663	T927	T928	nmod	in,vivo
R664	T928	T926	nmod	vivo,function
R665	T929	T915	aux	has,determined
R666	T930	T915	neg	not,determined
R667	T931	T915	auxpass	been,determined
R668	T932	T915	punct	.,determined
R669	T934	T935	poss	Our,study
R67	T211	T202	prep	with,confer
R670	T935	T937	nsubj	study,uncovers
R671	T936	T935	amod	current,study
R672	T938	T937	dobj	PPARδ,uncovers
R673	T939	T937	prep	as,uncovers
R674	T940	T941	det	the,factor
R675	T941	T939	pobj	factor,as
R676	T942	T941	amod	first,factor
R677	T943	T941	compound	transcription,factor
R678	T944	T941	amod	able,factor
R679	T945	T946	aux	to,drive
R68	T212	T213	amod	improved,profiles
R680	T946	T944	xcomp	drive,able
R681	T947	T948	det	the,formation
R682	T948	T946	dobj	formation,drive
R683	T949	T948	prep	of,formation
R684	T950	T951	amod	functional,fibers
R685	T951	T949	pobj	fibers,of
R686	T952	T951	nmod	type,fibers
R687	T953	T952	nummod	I,type
R688	T954	T951	compound	muscle,fibers
R689	T955	T941	punct	", ",factor
R69	T213	T211	pobj	profiles,with
R690	T956	T957	poss	whose,activation
R691	T957	T958	dep	activation,entrains
R692	T958	T941	relcl	entrains,factor
R693	T959	T960	amod	complex,pathways
R694	T960	T958	dobj	pathways,entrains
R695	T961	T962	preconj	both,enhancing
R696	T962	T960	acl	enhancing,pathways
R697	T963	T964	amod	physical,performance
R698	T964	T962	dobj	performance,enhancing
R699	T965	T962	cc	and,enhancing
R7	T120	T121	det	a,mouse
R70	T214	T213	amod	metabolic,profiles
R700	T966	T962	conj	creating,enhancing
R701	T967	T968	det	a,state
R702	T968	T966	dobj	state,creating
R703	T969	T968	prep	of,state
R704	T970	T971	compound	obesity,resistance
R705	T971	T969	pobj	resistance,of
R706	T972	T937	punct	.,uncovers
R71	T215	T202	punct	", ",confer
R72	T216	T217	advmod	even,in
R723	T1279	T1280	nsubj	Activation,Leads
R724	T1281	T1279	prep	of,Activation
R725	T1282	T1281	pobj	PPARδ,of
R726	T1283	T1280	prep	to,Leads
R727	T1284	T1285	compound	Muscle,Fiber
R728	T1285	T1286	compound	Fiber,Transformation
R729	T1286	T1283	pobj	Transformation,to
R73	T217	T202	prep	in,confer
R730	T1288	T1289	det	A,role
R731	T1289	T1290	nsubjpass	role,suggested
R732	T1291	T1289	prep	of,role
R733	T1292	T1291	pobj	PPARδ,of
R734	T1293	T1289	prep	in,role
R735	T1294	T1295	compound	muscle,fiber
R736	T1295	T1293	pobj	fiber,in
R737	T1296	T1290	auxpass	was,suggested
R738	T1297	T1290	agent	by,suggested
R739	T1298	T1299	poss	its,expression
R74	T218	T219	det	the,absence
R740	T1299	T1297	pobj	expression,by
R741	T1300	T1299	amod	enhanced,expression
R742	T1301	T1299	punct	—,expression
R743	T1302	T1299	prep	at,expression
R744	T1303	T1302	pobj	levels,at
R745	T1304	T1305	npadvmod	10,greater
R746	T1305	T1303	amod	greater,levels
R747	T1306	T1304	punct	-,10
R748	T1307	T1304	advmod	fold,10
R749	T1308	T1304	cc	and,10
R75	T219	T217	pobj	absence,in
R750	T1309	T1304	conj	50,10
R751	T1310	T1309	punct	-,50
R752	T1311	T1309	advmod	fold,50
R753	T1312	T1305	prep	than,greater
R754	T1313	T1314	nmod	PPARα,isoforms
R755	T1314	T1312	pobj	isoforms,than
R756	T1315	T1313	cc	and,PPARα
R757	T1316	T1313	punct	γ,PPARα
R758	T1317	T1290	punct	", ",suggested
R759	T1318	T1290	advmod	respectively,suggested
R76	T220	T219	prep	of,absence
R760	T1319	T1320	punct	(,data
R761	T1320	T1290	parataxis	data,suggested
R762	T1321	T1320	amod	unpublished,data
R763	T1322	T1320	punct	),data
R764	T1323	T1290	punct	.,suggested
R765	T1325	T1326	det	An,examination
R766	T1326	T1327	nsubj	examination,reveals
R767	T1327	T1334	ccomp	reveals,resembles
R768	T1328	T1326	prep	of,examination
R769	T1329	T1328	pobj	PPARδ,of
R77	T221	T220	pobj	exercise,of
R770	T1330	T1326	prep	in,examination
R771	T1331	T1332	amod	different,fibers
R772	T1332	T1330	pobj	fibers,in
R773	T1333	T1332	compound	muscle,fibers
R774	T1335	T1336	det	a,level
R775	T1336	T1327	dobj	level,reveals
R776	T1337	T1338	advmod	significantly,higher
R777	T1338	T1336	amod	higher,level
R778	T1339	T1327	prep	in,reveals
R779	T1340	T1341	nmod	type,muscle
R78	T222	T202	punct	.,confer
R780	T1341	T1339	pobj	muscle,in
R781	T1342	T1340	nummod	I,type
R782	T1343	T1344	punct	(,soleus
R783	T1344	T1341	parataxis	soleus,muscle
R784	T1345	T1344	punct	),soleus
R785	T1346	T1327	advcl	relative,reveals
R786	T1347	T1346	prep	to,relative
R787	T1348	T1349	npadvmod	type,rich
R788	T1349	T1352	amod	rich,muscle
R789	T1350	T1348	nummod	II,type
R79	T224	T225	det	These,results
R790	T1351	T1349	punct	–,rich
R791	T1352	T1347	pobj	muscle,to
R792	T1353	T1354	punct	(,longus
R793	T1354	T1352	parataxis	longus,muscle
R794	T1355	T1354	compound	extensor,longus
R795	T1356	T1354	compound	digitorum,longus
R796	T1357	T1354	punct	),longus
R797	T1358	T1352	cc	or,muscle
R798	T1359	T1360	nmod	type,muscle
R799	T1360	T1352	conj	muscle,muscle
R8	T121	T119	pobj	mouse,of
R80	T225	T226	nsubj	results,demonstrate
R800	T1361	T1359	nummod	I,type
R801	T1362	T1359	cc	and,type
R802	T1363	T1359	conj	type,type
R803	T1364	T1363	nummod	II,type
R804	T1365	T1360	amod	mixed,muscle
R805	T1366	T1367	punct	(,gastrocnemius
R806	T1367	T1360	parataxis	gastrocnemius,muscle
R807	T1368	T1367	punct	),gastrocnemius
R808	T1369	T1370	punct	(,Figure
R809	T1370	T1327	parataxis	Figure,reveals
R81	T227	T228	mark	that,analyzed
R810	T1371	T1370	nummod	1A,Figure
R811	T1372	T1370	punct	),Figure
R812	T1373	T1334	punct	;,resembles
R813	T1374	T1375	det	this,pattern
R814	T1375	T1334	nsubj	pattern,resembles
R815	T1376	T1375	compound	expression,pattern
R816	T1377	T1334	advmod	closely,resembles
R817	T1378	T1334	dobj	that,resembles
R818	T1379	T1378	prep	of,that
R819	T1380	T1379	pobj	PGC,of
R82	T228	T226	ccomp	analyzed,demonstrate
R820	T1381	T1380	punct	-,PGC
R821	T1382	T1380	nummod	1α,PGC
R822	T1383	T1384	punct	(,Lin
R823	T1384	T1334	meta	Lin,resembles
R824	T1385	T1384	nmod	et,Lin
R825	T1386	T1384	nmod	al.,Lin
R826	T1387	T1384	nummod	2002,Lin
R827	T1388	T1384	punct	),Lin
R828	T1389	T1334	punct	.,resembles
R829	T1391	T1392	det	A,pattern
R83	T229	T230	amod	complex,properties
R830	T1392	T1394	nsubjpass	pattern,found
R831	T1393	T1392	amod	similar,pattern
R832	T1395	T1396	cc	but,with
R833	T1396	T1392	nmod	with,pattern
R834	T1397	T1398	advmod	more,pronounced
R835	T1398	T1399	amod	pronounced,differences
R836	T1399	T1396	pobj	differences,with
R837	T1400	T1394	auxpass	was,found
R838	T1401	T1394	prep	at,found
R839	T1402	T1403	det	the,level
R84	T230	T228	nsubjpass	properties,analyzed
R840	T1403	T1401	pobj	level,at
R841	T1404	T1403	compound	protein,level
R842	T1405	T1406	punct	(,Figure
R843	T1406	T1394	parataxis	Figure,found
R844	T1407	T1406	nummod	1B,Figure
R845	T1408	T1406	punct	),Figure
R846	T1409	T1394	punct	.,found
R847	T1411	T1412	aux	To,assess
R848	T1412	T1414	advcl	assess,generated
R849	T1413	T1412	advmod	directly,assess
R85	T231	T230	amod	physiologic,properties
R850	T1415	T1416	det	the,role
R851	T1416	T1412	dobj	role,assess
R852	T1417	T1416	prep	of,role
R853	T1418	T1417	pobj	activation,of
R854	T1419	T1418	prep	of,activation
R855	T1420	T1419	pobj	PPARδ,of
R856	T1421	T1416	prep	in,role
R857	T1422	T1421	pobj	control,in
R858	T1423	T1422	prep	of,control
R859	T1424	T1425	compound	muscle,fiber
R86	T232	T233	amod	such,as
R860	T1425	T1426	compound	fiber,plasticity
R861	T1426	T1423	pobj	plasticity,of
R862	T1427	T1426	cc	and,plasticity
R863	T1428	T1429	amod	mitochondrial,biogenesis
R864	T1429	T1426	conj	biogenesis,plasticity
R865	T1430	T1414	punct	", ",generated
R866	T1431	T1414	nsubj	we,generated
R867	T1432	T1414	dobj	mice,generated
R868	T1433	T1432	acl	expressing,mice
R869	T1434	T1435	det	a,transgene
R87	T233	T230	prep	as,properties
R870	T1435	T1433	dobj	transgene,expressing
R871	T1436	T1437	prep	in,fused
R872	T1437	T1435	relcl	fused,transgene
R873	T1438	T1436	pobj	which,in
R874	T1439	T1440	det	the,domain
R875	T1440	T1437	nsubjpass	domain,fused
R876	T1441	T1442	nummod	78,acid
R877	T1442	T1440	compound	acid,domain
R878	T1443	T1442	punct	-,acid
R879	T1444	T1442	compound	amino,acid
R88	T234	T233	pobj	fatigue,as
R880	T1445	T1442	punct	-,acid
R881	T1446	T1447	compound	VP16,activation
R882	T1447	T1440	compound	activation,domain
R883	T1448	T1437	auxpass	was,fused
R884	T1449	T1437	prep	to,fused
R885	T1450	T1451	det	the,terminus
R886	T1451	T1449	pobj	terminus,to
R887	T1452	T1451	compound	N,terminus
R888	T1453	T1451	punct	-,terminus
R889	T1454	T1451	prep	of,terminus
R89	T235	T234	punct	", ",fatigue
R890	T1455	T1456	amod	full,length
R891	T1456	T1458	compound	length,PPARδ
R892	T1457	T1456	punct	-,length
R893	T1458	T1454	pobj	PPARδ,of
R894	T1459	T1437	punct	", ",fused
R895	T1460	T1437	prep	under,fused
R896	T1461	T1460	pobj	control,under
R897	T1462	T1461	prep	of,control
R898	T1463	T1464	det	the,promoter
R899	T1464	T1462	pobj	promoter,of
R9	T122	T121	amod	capable,mouse
R90	T236	T234	conj	endurance,fatigue
R900	T1465	T1466	nummod	2.2,kb
R901	T1466	T1464	nmod	kb,promoter
R902	T1467	T1466	punct	-,kb
R903	T1468	T1464	amod	human,promoter
R904	T1469	T1470	npadvmod	α,skeletal
R905	T1470	T1464	amod	skeletal,promoter
R906	T1471	T1470	punct	-,skeletal
R907	T1472	T1464	compound	actin,promoter
R908	T1473	T1414	punct	.,generated
R909	T1475	T1476	prep	In,expressed
R91	T237	T236	punct	", ",endurance
R910	T1477	T1475	pobj	agreement,In
R911	T1478	T1477	prep	with,agreement
R912	T1479	T1480	det	the,characterization
R913	T1480	T1478	pobj	characterization,with
R914	T1481	T1480	amod	previous,characterization
R915	T1482	T1480	prep	of,characterization
R916	T1483	T1484	det	this,promoter
R917	T1484	T1482	pobj	promoter,of
R918	T1485	T1486	punct	(,Brennan
R919	T1486	T1480	meta	Brennan,characterization
R92	T238	T236	cc	and,endurance
R920	T1487	T1486	cc	and,Brennan
R921	T1488	T1486	conj	Hardeman,Brennan
R922	T1489	T1488	nummod	1993,Hardeman
R923	T1490	T1488	punct	;,Hardeman
R924	T1491	T1488	conj	Clapham,Hardeman
R925	T1492	T1491	nmod	et,Clapham
R926	T1493	T1491	nmod	al.,Clapham
R927	T1494	T1491	nummod	2000,Clapham
R928	T1495	T1491	punct	),Clapham
R929	T1496	T1476	punct	", ",expressed
R93	T63	T61	prep	of,Regulation
R930	T1497	T1498	det	the,transgene
R931	T1498	T1476	nsubjpass	transgene,expressed
R932	T1499	T1500	compound	VP16,PPARδ
R933	T1500	T1498	compound	PPARδ,transgene
R934	T1501	T1500	punct	-,PPARδ
R935	T1502	T1476	auxpass	was,expressed
R936	T1503	T1476	advmod	selectively,expressed
R937	T1504	T1476	prep	in,expressed
R938	T1505	T1506	amod	skeletal,muscle
R939	T1506	T1504	pobj	muscle,in
R94	T64	T65	compound	Muscle,Fiber
R940	T1507	T1476	punct	", ",expressed
R941	T1508	T1509	mark	with,less
R942	T1509	T1476	advcl	less,expressed
R943	T1510	T1509	nummod	10,less
R944	T1511	T1510	punct	-,10
R945	T1512	T1510	advmod	fold,10
R946	T1513	T1509	prep	in,less
R947	T1514	T1515	det	the,heart
R948	T1515	T1513	pobj	heart,in
R949	T1516	T1517	punct	(,Figure
R95	T65	T66	compound	Fiber,Type
R950	T1517	T1476	parataxis	Figure,expressed
R951	T1518	T1517	nummod	1C,Figure
R952	T1519	T1517	punct	),Figure
R953	T1520	T1476	punct	.,expressed
R954	T1522	T1523	prep	Among,appeared
R955	T1524	T1525	amod	different,types
R956	T1525	T1522	pobj	types,Among
R957	T1526	T1525	prep	of,types
R958	T1527	T1528	compound	muscle,fibers
R959	T1528	T1526	pobj	fibers,of
R96	T66	T63	pobj	Type,of
R960	T1529	T1523	punct	", ",appeared
R961	T1530	T1531	det	the,levels
R962	T1531	T1523	nsubj	levels,appeared
R963	T1532	T1531	prep	of,levels
R964	T1533	T1534	compound	VP16,PPARδ
R965	T1534	T1536	compound	PPARδ,expression
R966	T1535	T1534	punct	-,PPARδ
R967	T1536	T1532	pobj	expression,of
R968	T1537	T1538	aux	to,be
R969	T1538	T1523	xcomp	be,appeared
R97	T67	T66	cc	and,Type
R970	T1539	T1538	acomp	similar,be
R971	T1540	T1541	punct	(,data
R972	T1541	T1538	parataxis	data,be
R973	T1542	T1541	amod	unpublished,data
R974	T1543	T1541	punct	),data
R975	T1544	T1523	punct	.,appeared
R976	T1546	T1547	mark	As,shown
R977	T1547	T1548	advcl	shown,produced
R978	T1549	T1547	prep	in,shown
R979	T1550	T1549	pobj	Figure,in
R98	T68	T69	compound	Running,Endurance
R980	T1551	T1550	nummod	1D,Figure
R981	T1552	T1547	prep	for,shown
R982	T1553	T1554	compound	gastrocnemius,muscle
R983	T1554	T1552	pobj	muscle,for
R984	T1555	T1548	punct	", ",produced
R985	T1556	T1557	compound	VP16,PPARδ
R986	T1557	T1559	compound	PPARδ,protein
R987	T1558	T1557	punct	-,PPARδ
R988	T1559	T1548	nsubjpass	protein,produced
R989	T1560	T1559	compound	fusion,protein
R99	T69	T66	conj	Endurance,Type
R990	T1561	T1548	auxpass	was,produced
R991	T1562	T1548	prep	at,produced
R992	T1563	T1564	det	a,level
R993	T1564	T1562	pobj	level,at
R994	T1565	T1564	amod	similar,level
R995	T1566	T1565	prep	to,similar
R996	T1567	T1566	pobj	that,to
R997	T1568	T1567	prep	of,that
R998	T1569	T1570	amod	endogenous,PPARδ
R999	T1570	T1568	pobj	PPARδ,of

PMC:509410 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

PMC:509410 JSON TXT 6 Projects