craft-sa-dev Home  

PMC:509305 / 9445-18236 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T6732 0-7 NN denotes Mapping
T6733 8-10 IN denotes of
T6734 11-15 NNS denotes Loci
T6735 16-28 VBG denotes Predisposing
T6736 29-31 IN denotes to
T6737 32-37 NN denotes Lupus
T6738 38-40 IN denotes in
T6739 41-44 DT denotes the
T6741 45-51 NN denotes Hybrid
T6740 52-58 NN denotes Strain
T6742 59-60 -LRB- denotes (
T6743 60-63 CD denotes 129
T6744 64-65 SYM denotes ×
T6745 66-71 NN denotes C57BL
T6746 71-72 HYPH denotes /
T6747 72-73 CD denotes 6
T6748 73-74 -RRB- denotes )
T6749 74-234 sentence denotes Mice were genotyped with 143 microsatellite markers distributed throughout the autosomes such that 98% of the genes were within 20 cM of an informative marker.
T6750 75-79 NNS denotes Mice
T6752 80-84 VBD denotes were
T6751 85-94 VBN denotes genotyped
T6753 95-99 IN denotes with
T6754 100-103 CD denotes 143
T6756 104-118 NN denotes microsatellite
T6755 119-126 NNS denotes markers
T6757 127-138 VBN denotes distributed
T6758 139-149 IN denotes throughout
T6759 150-153 DT denotes the
T6760 154-163 NNS denotes autosomes
T6761 164-168 JJ denotes such
T6763 169-173 IN denotes that
T6764 174-176 CD denotes 98
T6765 176-177 NN denotes %
T6766 178-180 IN denotes of
T6767 181-184 DT denotes the
T6768 185-190 NNS denotes genes
T6762 191-195 VBD denotes were
T6769 196-202 IN denotes within
T6770 203-205 CD denotes 20
T6771 206-208 NNS denotes cM
T6772 209-211 IN denotes of
T6773 212-214 DT denotes an
T6775 215-226 JJ denotes informative
T6774 227-233 NN denotes marker
T6776 233-234 . denotes .
T6777 234-341 sentence denotes A summary of the genome-wide linkage analysis for each of the disease traits measured is shown in Table 3.
T6778 235-236 DT denotes A
T6779 237-244 NN denotes summary
T6781 245-247 IN denotes of
T6782 248-251 DT denotes the
T6784 252-258 NN denotes genome
T6786 258-259 HYPH denotes -
T6785 259-263 JJ denotes wide
T6787 264-271 NN denotes linkage
T6783 272-280 NN denotes analysis
T6788 281-284 IN denotes for
T6789 285-289 DT denotes each
T6790 290-292 IN denotes of
T6791 293-296 DT denotes the
T6793 297-304 NN denotes disease
T6792 305-311 NNS denotes traits
T6794 312-320 VBN denotes measured
T6795 321-323 VBZ denotes is
T6780 324-329 VBN denotes shown
T6796 330-332 IN denotes in
T6797 333-338 NN denotes Table
T6798 339-340 CD denotes 3
T6799 340-341 . denotes .
T6800 341-425 sentence denotes The areas of linkage were defined according to the parental origin, 129 or C57BL/6.
T6801 342-345 DT denotes The
T6802 346-351 NNS denotes areas
T6804 352-354 IN denotes of
T6805 355-362 NN denotes linkage
T6806 363-367 VBD denotes were
T6803 368-375 VBN denotes defined
T6807 376-385 VBG denotes according
T6808 386-388 IN denotes to
T6809 389-392 DT denotes the
T6811 393-401 JJ denotes parental
T6810 402-408 NN denotes origin
T6812 408-410 , denotes ,
T6813 410-413 CD denotes 129
T6814 414-416 CC denotes or
T6815 417-422 NN denotes C57BL
T6816 422-423 HYPH denotes /
T6817 423-424 CD denotes 6
T6818 424-425 . denotes .
T6819 425-685 sentence denotes Only linkages identified in both experimental groups are reported in Table 3, with the exception of the Chromosome 1 distal segment, where the linkage analysis could not be applied to the (129 × C57BL/6)F2.Apcs −/− mice as this region was of fixed 129 origin.
T6820 426-430 RB denotes Only
T6821 431-439 NNS denotes linkages
T6823 440-450 VBN denotes identified
T6824 451-453 IN denotes in
T6825 454-458 DT denotes both
T6827 459-471 JJ denotes experimental
T6826 472-478 NNS denotes groups
T6828 479-482 VBP denotes are
T6822 483-491 VBN denotes reported
T6829 492-494 IN denotes in
T6830 495-500 NN denotes Table
T6831 501-502 CD denotes 3
T6832 502-504 , denotes ,
T6833 504-508 IN denotes with
T6834 509-512 DT denotes the
T6835 513-522 NN denotes exception
T6836 523-525 IN denotes of
T6837 526-529 DT denotes the
T6839 530-540 NN denotes Chromosome
T6840 541-542 CD denotes 1
T6841 543-549 JJ denotes distal
T6838 550-557 NN denotes segment
T6842 557-559 , denotes ,
T6843 559-564 WRB denotes where
T6845 565-568 DT denotes the
T6847 569-576 NN denotes linkage
T6846 577-585 NN denotes analysis
T6848 586-591 MD denotes could
T6849 592-595 RB denotes not
T6850 596-598 VB denotes be
T6844 599-606 VBN denotes applied
T6851 607-609 IN denotes to
T6852 610-613 DT denotes the
T6854 614-615 -LRB- denotes (
T6856 615-618 CD denotes 129
T6857 619-620 SYM denotes ×
T6858 621-626 NN denotes C57BL
T6859 626-627 HYPH denotes /
T6860 627-628 CD denotes 6
T6861 628-629 -RRB- denotes )
T6855 629-631 NN denotes F2
T6862 631-632 HYPH denotes .
T6863 632-636 NN denotes Apcs
T6864 637-638 SYM denotes −
T6865 638-639 HYPH denotes /
T6866 639-640 SYM denotes −
T6853 641-645 NNS denotes mice
T6867 646-648 IN denotes as
T6869 649-653 DT denotes this
T6870 654-660 NN denotes region
T6868 661-664 VBD denotes was
T6871 665-667 IN denotes of
T6872 668-673 VBN denotes fixed
T6874 674-677 CD denotes 129
T6873 678-684 NN denotes origin
T6875 684-685 . denotes .
T6876 685-782 sentence denotes Chromosomes where linkages were present only in one of the two cohorts are shown in Figures 1–3.
T6877 686-697 NNS denotes Chromosomes
T6879 698-703 WRB denotes where
T6881 704-712 NNS denotes linkages
T6880 713-717 VBD denotes were
T6882 718-725 JJ denotes present
T6883 726-730 RB denotes only
T6884 731-733 IN denotes in
T6885 734-737 CD denotes one
T6886 738-740 IN denotes of
T6887 741-744 DT denotes the
T6889 745-748 CD denotes two
T6888 749-756 NNS denotes cohorts
T6890 757-760 VBP denotes are
T6878 761-766 VBN denotes shown
T6891 767-769 IN denotes in
T6892 770-777 NNS denotes Figures
T6893 778-779 CD denotes 1
T6894 779-780 SYM denotes –
T6895 780-781 CD denotes 3
T6896 781-782 . denotes .
T6897 782-2674 sentence denotes Figure 1 Linkage of Chromosome 2 with ANA and Anti-Chromatin Abs in (129 × C57BL/6)F2.Apcs−/− Mice These associations were not detected in (129 × C57BL/6)F2 animals. Centimorgan positions were deduced by interval mapping, anchoring marker locations to data from http://www.informatics.jax.org. Dotted lines and the dashed line indicate the threshold over which linkages were considered suggestive or significant, respectively, as defined in Materials and Methods. Figure 3 Linkage of Chromosome 4 with Anti-dsDNA Abs The estimated peak in (129 × C57BL/6)F2 mice was at position 51.3 cM, whilst in the (129 × C57BL/6)F2.Apcs−/−animals it was was at position 71 cM, indicating that most likely these were two independent loci. Centimorgan positions were deduced by interval mapping, anchoring marker locations to data from http://www.informatics.jax.org. Dotted lines the indicate threshold over which linkage was considered suggestive, as defined in Materials and Methods. Table 3 Summary of Genome-Wide Linkage Analysis in Apcs −/− and Wild-Type (129 × C57BL/6)F2 Female Mice a Suggestive linkage b Significant linkage c Highly significant linkage as defined in the material and method section Chr, Chromosome; Est. Peak, Estimated Peak; LOD, logarithm of odds; N/A, not applicable Chromosomes where linkages were not present in both experimental groups are not illustrated. See Materials and Methods for details. The oligonucleotide sequences and approximate positions of the microsatellite markers used were taken from the Mouse Genome Database, Mouse Genome Informatics, Jackson Laboratory, Bar Harbor, Maine, United States (http://www.informatics.jax.org) The quantitative trait linkage (QTL) analysis identified several intervals on Chromosome 1 with linkage to disease serological markers, and these regions were all derived from the 129 mouse strain (see Table 3; Figures 4 and 5).
T6898 2446-2449 DT denotes The
T6900 2450-2462 JJ denotes quantitative
T6902 2463-2468 NN denotes trait
T6901 2469-2476 NN denotes linkage
T6903 2477-2478 -LRB- denotes (
T6904 2478-2481 NN denotes QTL
T6905 2481-2482 -RRB- denotes )
T6899 2483-2491 NN denotes analysis
T6906 2492-2502 VBD denotes identified
T6907 2503-2510 JJ denotes several
T6908 2511-2520 NNS denotes intervals
T6909 2521-2523 IN denotes on
T6910 2524-2534 NN denotes Chromosome
T6911 2535-2536 CD denotes 1
T6912 2537-2541 IN denotes with
T6913 2542-2549 NN denotes linkage
T6914 2550-2552 IN denotes to
T6915 2553-2560 NN denotes disease
T6917 2561-2572 JJ denotes serological
T6916 2573-2580 NNS denotes markers
T6918 2580-2582 , denotes ,
T6919 2582-2585 CC denotes and
T6920 2586-2591 DT denotes these
T6921 2592-2599 NNS denotes regions
T6923 2600-2604 VBD denotes were
T6924 2605-2608 RB denotes all
T6922 2609-2616 VBN denotes derived
T6925 2617-2621 IN denotes from
T6926 2622-2625 DT denotes the
T6928 2626-2629 CD denotes 129
T6929 2630-2635 NN denotes mouse
T6927 2636-2642 NN denotes strain
T6930 2643-2644 -LRB- denotes (
T6932 2644-2647 VB denotes see
T6933 2648-2653 NN denotes Table
T6934 2654-2655 CD denotes 3
T6935 2655-2656 : denotes ;
T6936 2657-2664 NNS denotes Figures
T6931 2665-2666 CD denotes 4
T6937 2667-2670 CC denotes and
T6938 2671-2672 CD denotes 5
T6939 2672-2673 -RRB- denotes )
T6940 2673-2674 . denotes .
T6941 2674-3068 sentence denotes Interestingly, whilst ANA and anti-chromatin Ab levels showed suggestive or significant linkages only to the telomeric region of Chromosome 1, with an estimated peak occurring at a position approximately 90 cM near the Apcs gene, anti-dsDNA or anti-ssDNA Ab production was also linked to other segments on Chromosome 1, indicating a more complex genetic contribution from the 129 mouse strain.
T6942 2675-2688 RB denotes Interestingly
T6944 2688-2690 , denotes ,
T6945 2690-2696 IN denotes whilst
T6947 2697-2700 NN denotes ANA
T6949 2701-2704 CC denotes and
T6950 2705-2719 JJ denotes anti-chromatin
T6951 2720-2722 NN denotes Ab
T6948 2723-2729 NNS denotes levels
T6946 2730-2736 VBD denotes showed
T6952 2737-2747 JJ denotes suggestive
T6954 2748-2750 CC denotes or
T6955 2751-2762 JJ denotes significant
T6953 2763-2771 NNS denotes linkages
T6956 2772-2776 RB denotes only
T6957 2777-2779 IN denotes to
T6958 2780-2783 DT denotes the
T6960 2784-2793 JJ denotes telomeric
T6959 2794-2800 NN denotes region
T6961 2801-2803 IN denotes of
T6962 2804-2814 NN denotes Chromosome
T6963 2815-2816 CD denotes 1
T6964 2816-2818 , denotes ,
T6965 2818-2822 IN denotes with
T6966 2823-2825 DT denotes an
T6968 2826-2835 VBN denotes estimated
T6967 2836-2840 NN denotes peak
T6969 2841-2850 VBG denotes occurring
T6970 2851-2853 IN denotes at
T6971 2854-2855 DT denotes a
T6972 2856-2864 NN denotes position
T6973 2865-2878 RB denotes approximately
T6974 2879-2881 CD denotes 90
T6975 2882-2884 NN denotes cM
T6976 2885-2889 IN denotes near
T6977 2890-2893 DT denotes the
T6979 2894-2898 NN denotes Apcs
T6978 2899-2903 NN denotes gene
T6980 2903-2905 , denotes ,
T6981 2905-2915 JJ denotes anti-dsDNA
T6983 2916-2918 CC denotes or
T6984 2919-2929 JJ denotes anti-ssDNA
T6985 2930-2932 NN denotes Ab
T6982 2933-2943 NN denotes production
T6986 2944-2947 VBD denotes was
T6987 2948-2952 RB denotes also
T6943 2953-2959 VBN denotes linked
T6988 2960-2962 IN denotes to
T6989 2963-2968 JJ denotes other
T6990 2969-2977 NNS denotes segments
T6991 2978-2980 IN denotes on
T6992 2981-2991 NN denotes Chromosome
T6993 2992-2993 CD denotes 1
T6994 2993-2995 , denotes ,
T6995 2995-3005 VBG denotes indicating
T6996 3006-3007 DT denotes a
T6998 3008-3012 RBR denotes more
T6999 3013-3020 JJ denotes complex
T7000 3021-3028 JJ denotes genetic
T6997 3029-3041 NN denotes contribution
T7001 3042-3046 IN denotes from
T7002 3047-3050 DT denotes the
T7004 3051-3054 CD denotes 129
T7005 3055-3060 NN denotes mouse
T7003 3061-3067 NN denotes strain
T7006 3067-3068 . denotes .
T7007 3068-4328 sentence denotes Figure 4 Interval Mapping Scans Showing QTL on Chromosome 1 with Anti-dsDNA and Anti-ssDNA Abs Centimorgan positions were deduced by interval mapping, anchoring marker locations to data from http://www.informatics.jax.org. Dotted lines indicate the threshold over which linkage was considered suggestive, dashed lines indicate the threshold over which linkage was considered significant, and dotted/dashed lines indicate highly significant linkage, as defined in Materials and Methods. See Table 3 for additional details. Figure 5 Interval Mapping Scans Showing QTL on Chromosome 1 with ANA and Anti-Chromatin Abs Centimorgan positions were deduced by interval mapping, anchoring marker locations to data from http://www.informatics.jax.org. Dotted lines indicate the threshold over which linkage was considered suggestive, and dashed lines indicate the threshold over which linkage was considered significant, as defined in Materials and Methods. See Table 3 for additional details. Guided by these observations, we investigated whether the increased levels of ANA and anti-chromatin Ab observed in the Apcs −/− mice were caused by a gene(s) within the fixed 129 region surrounding the mutated Apcs gene, rather than caused by the mutated Apcs gene itself.
T7008 4055-4061 VBN denotes Guided
T7010 4062-4064 IN denotes by
T7011 4065-4070 DT denotes these
T7012 4071-4083 NNS denotes observations
T7013 4083-4085 , denotes ,
T7014 4085-4087 PRP denotes we
T7009 4088-4100 VBD denotes investigated
T7015 4101-4108 IN denotes whether
T7017 4109-4112 DT denotes the
T7019 4113-4122 VBN denotes increased
T7018 4123-4129 NNS denotes levels
T7020 4130-4132 IN denotes of
T7021 4133-4136 NN denotes ANA
T7022 4137-4140 CC denotes and
T7023 4141-4155 JJ denotes anti-chromatin
T7024 4156-4158 NN denotes Ab
T7025 4159-4167 VBN denotes observed
T7026 4168-4170 IN denotes in
T7027 4171-4174 DT denotes the
T7029 4175-4179 NN denotes Apcs
T7030 4180-4181 SYM denotes −
T7031 4181-4182 HYPH denotes /
T7032 4182-4183 SYM denotes −
T7028 4184-4188 NNS denotes mice
T7033 4189-4193 VBD denotes were
T7016 4194-4200 VBN denotes caused
T7034 4201-4203 IN denotes by
T7035 4204-4205 DT denotes a
T7036 4206-4210 NN denotes gene
T7037 4210-4211 -LRB- denotes (
T7038 4211-4212 AFX denotes s
T7039 4212-4213 -RRB- denotes )
T7040 4214-4220 IN denotes within
T7041 4221-4224 DT denotes the
T7043 4225-4230 VBN denotes fixed
T7044 4231-4234 CD denotes 129
T7042 4235-4241 NN denotes region
T7045 4242-4253 VBG denotes surrounding
T7046 4254-4257 DT denotes the
T7048 4258-4265 VBN denotes mutated
T7049 4266-4270 NN denotes Apcs
T7047 4271-4275 NN denotes gene
T7050 4275-4277 , denotes ,
T7051 4277-4283 RB denotes rather
T7052 4284-4288 IN denotes than
T7053 4289-4295 VBN denotes caused
T7054 4296-4298 IN denotes by
T7055 4299-4302 DT denotes the
T7057 4303-4310 VBN denotes mutated
T7058 4311-4315 NN denotes Apcs
T7056 4316-4320 NN denotes gene
T7059 4321-4327 PRP denotes itself
T7060 4327-4328 . denotes .
T7061 4328-4595 sentence denotes We compared the levels of these auto-Abs between all (129 × C57BL/6)F2.Apcs −/− mice and a group of 33 wild-type mice that were selected for being homozygous 129 in the region of Chromosome 1 between microsatellites D1Mit105 and D1Mit 223 (80–106 cM) (Figure 6A–6D).
T7062 4329-4331 PRP denotes We
T7063 4332-4340 VBD denotes compared
T7064 4341-4344 DT denotes the
T7065 4345-4351 NNS denotes levels
T7066 4352-4354 IN denotes of
T7067 4355-4360 DT denotes these
T7068 4361-4369 NNS denotes auto-Abs
T7069 4370-4377 IN denotes between
T7070 4378-4381 DT denotes all
T7072 4382-4383 -LRB- denotes (
T7073 4383-4386 CD denotes 129
T7075 4387-4388 SYM denotes ×
T7076 4389-4394 NN denotes C57BL
T7077 4394-4395 HYPH denotes /
T7078 4395-4396 CD denotes 6
T7079 4396-4397 -RRB- denotes )
T7074 4397-4399 NN denotes F2
T7080 4399-4400 HYPH denotes .
T7081 4400-4404 NN denotes Apcs
T7082 4405-4406 SYM denotes −
T7083 4406-4407 HYPH denotes /
T7084 4407-4408 SYM denotes −
T7071 4409-4413 NNS denotes mice
T7085 4414-4417 CC denotes and
T7086 4418-4419 DT denotes a
T7087 4420-4425 NN denotes group
T7088 4426-4428 IN denotes of
T7089 4429-4431 CD denotes 33
T7091 4432-4436 JJ denotes wild
T7093 4436-4437 HYPH denotes -
T7092 4437-4441 NN denotes type
T7090 4442-4446 NNS denotes mice
T7094 4447-4451 WDT denotes that
T7096 4452-4456 VBD denotes were
T7095 4457-4465 VBN denotes selected
T7097 4466-4469 IN denotes for
T7098 4470-4475 VBG denotes being
T7099 4476-4486 JJ denotes homozygous
T7100 4487-4490 CD denotes 129
T7101 4491-4493 IN denotes in
T7102 4494-4497 DT denotes the
T7103 4498-4504 NN denotes region
T7104 4505-4507 IN denotes of
T7105 4508-4518 NN denotes Chromosome
T7106 4519-4520 CD denotes 1
T7107 4521-4528 IN denotes between
T7108 4529-4544 NNS denotes microsatellites
T7109 4545-4553 NN denotes D1Mit105
T7110 4554-4557 CC denotes and
T7111 4558-4563 NN denotes D1Mit
T7112 4564-4567 CD denotes 223
T7113 4568-4569 -LRB- denotes (
T7115 4569-4571 CD denotes 80
T7117 4571-4572 SYM denotes –
T7116 4572-4575 CD denotes 106
T7114 4576-4578 NN denotes cM
T7118 4578-4579 -RRB- denotes )
T7119 4580-4581 -LRB- denotes (
T7121 4581-4587 NN denotes Figure
T7120 4588-4590 NN denotes 6A
T7122 4590-4591 SYM denotes –
T7123 4591-4593 NN denotes 6D
T7124 4593-4594 -RRB- denotes )
T7125 4594-4595 . denotes .
T7126 4595-4730 sentence denotes In contrast to the results reported in Table 1, this comparison showed no significant differences between the two experimental groups.
T7127 4596-4598 IN denotes In
T7129 4599-4607 NN denotes contrast
T7130 4608-4610 IN denotes to
T7131 4611-4614 DT denotes the
T7132 4615-4622 NNS denotes results
T7133 4623-4631 VBN denotes reported
T7134 4632-4634 IN denotes in
T7135 4635-4640 NN denotes Table
T7136 4641-4642 CD denotes 1
T7137 4642-4644 , denotes ,
T7138 4644-4648 DT denotes this
T7139 4649-4659 NN denotes comparison
T7128 4660-4666 VBD denotes showed
T7140 4667-4669 DT denotes no
T7142 4670-4681 JJ denotes significant
T7141 4682-4693 NNS denotes differences
T7143 4694-4701 IN denotes between
T7144 4702-4705 DT denotes the
T7146 4706-4709 CD denotes two
T7147 4710-4722 JJ denotes experimental
T7145 4723-4729 NNS denotes groups
T7148 4729-4730 . denotes .
T7149 4730-4881 sentence denotes This result demonstrates that, most likely, the 129-derived region and not the lack of Apcs was mediating the production of ANA and anti-chromatin Ab.
T7150 4731-4735 DT denotes This
T7151 4736-4742 NN denotes result
T7152 4743-4755 VBZ denotes demonstrates
T7153 4756-4760 IN denotes that
T7155 4760-4762 , denotes ,
T7156 4762-4766 RBS denotes most
T7157 4767-4773 RB denotes likely
T7158 4773-4775 , denotes ,
T7159 4775-4778 DT denotes the
T7161 4779-4782 CD denotes 129
T7163 4782-4783 HYPH denotes -
T7162 4783-4790 VBN denotes derived
T7160 4791-4797 NN denotes region
T7164 4798-4801 CC denotes and
T7165 4802-4805 RB denotes not
T7166 4806-4809 DT denotes the
T7167 4810-4814 NN denotes lack
T7168 4815-4817 IN denotes of
T7169 4818-4822 NN denotes Apcs
T7170 4823-4826 VBD denotes was
T7154 4827-4836 VBG denotes mediating
T7171 4837-4840 DT denotes the
T7172 4841-4851 NN denotes production
T7173 4852-4854 IN denotes of
T7174 4855-4858 NN denotes ANA
T7175 4859-4862 CC denotes and
T7176 4863-4877 JJ denotes anti-chromatin
T7177 4878-4880 NN denotes Ab
T7178 4880-4881 . denotes .
T7179 4881-5139 sentence denotes Consistent with this explanation, we found that the 129 mice have significantly higher levels of Apcs in circulation compared with the C57BL/6 mice (median, 83 mg/l; range, 25–208; n = 16 versus median, 5 mg/l; range, 4–9; n = 10, respectively; p < 0.0001).
T7180 4882-4892 JJ denotes Consistent
T7182 4893-4897 IN denotes with
T7183 4898-4902 DT denotes this
T7184 4903-4914 NN denotes explanation
T7185 4914-4916 , denotes ,
T7186 4916-4918 PRP denotes we
T7181 4919-4924 VBD denotes found
T7187 4925-4929 IN denotes that
T7189 4930-4933 DT denotes the
T7191 4934-4937 CD denotes 129
T7190 4938-4942 NNS denotes mice
T7188 4943-4947 VBP denotes have
T7192 4948-4961 RB denotes significantly
T7193 4962-4968 JJR denotes higher
T7194 4969-4975 NNS denotes levels
T7195 4976-4978 IN denotes of
T7196 4979-4983 NN denotes Apcs
T7197 4984-4986 IN denotes in
T7198 4987-4998 NN denotes circulation
T7199 4999-5007 VBN denotes compared
T7200 5008-5012 IN denotes with
T7201 5013-5016 DT denotes the
T7203 5017-5022 NN denotes C57BL
T7204 5022-5023 HYPH denotes /
T7205 5023-5024 CD denotes 6
T7202 5025-5029 NNS denotes mice
T7206 5030-5031 -LRB- denotes (
T7208 5031-5037 NN denotes median
T7210 5037-5039 , denotes ,
T7211 5039-5041 CD denotes 83
T7209 5042-5044 NNS denotes mg
T7213 5044-5045 SYM denotes /
T7214 5045-5046 NN denotes l
T7215 5046-5047 : denotes ;
T7216 5048-5053 NN denotes range
T7218 5053-5055 , denotes ,
T7217 5055-5057 CD denotes 25
T7219 5057-5058 SYM denotes –
T7220 5058-5061 CD denotes 208
T7221 5061-5062 : denotes ;
T7222 5063-5064 NN denotes n
T7223 5065-5066 SYM denotes =
T7212 5067-5069 CD denotes 16
T7224 5070-5076 CC denotes versus
T7225 5077-5083 NN denotes median
T7227 5083-5085 , denotes ,
T7228 5085-5086 CD denotes 5
T7226 5087-5089 NN denotes mg
T7230 5089-5090 SYM denotes /
T7231 5090-5091 NN denotes l
T7232 5091-5092 : denotes ;
T7233 5093-5098 NN denotes range
T7235 5098-5100 , denotes ,
T7234 5100-5101 CD denotes 4
T7236 5101-5102 SYM denotes –
T7237 5102-5103 CD denotes 9
T7238 5103-5104 : denotes ;
T7239 5105-5106 NN denotes n
T7240 5107-5108 SYM denotes =
T7229 5109-5111 CD denotes 10
T7242 5111-5113 , denotes ,
T7241 5113-5125 RB denotes respectively
T7243 5125-5126 : denotes ;
T7244 5127-5128 NN denotes p
T7245 5129-5130 SYM denotes <
T7207 5131-5137 CD denotes 0.0001
T7246 5137-5138 -RRB- denotes )
T7247 5138-5139 . denotes .
T7248 5139-5289 sentence denotes The C57BL/6 strain has previously been reported to be one of the murine strains defined as low Apcs producers (Pepys et al. 1979; Baltz et al. 1980).
T7249 5140-5143 DT denotes The
T7251 5144-5149 NN denotes C57BL
T7252 5149-5150 HYPH denotes /
T7253 5150-5151 CD denotes 6
T7250 5152-5158 NN denotes strain
T7255 5159-5162 VBZ denotes has
T7256 5163-5173 RB denotes previously
T7257 5174-5178 VBN denotes been
T7254 5179-5187 VBN denotes reported
T7258 5188-5190 TO denotes to
T7259 5191-5193 VB denotes be
T7260 5194-5197 CD denotes one
T7261 5198-5200 IN denotes of
T7262 5201-5204 DT denotes the
T7264 5205-5211 JJ denotes murine
T7263 5212-5219 NNS denotes strains
T7265 5220-5227 VBN denotes defined
T7266 5228-5230 IN denotes as
T7267 5231-5234 JJ denotes low
T7269 5235-5239 NN denotes Apcs
T7268 5240-5249 NNS denotes producers
T7270 5250-5251 -LRB- denotes (
T7271 5251-5256 NNP denotes Pepys
T7272 5257-5259 FW denotes et
T7273 5260-5263 FW denotes al.
T7274 5264-5268 CD denotes 1979
T7275 5268-5269 : denotes ;
T7276 5270-5275 NNP denotes Baltz
T7277 5276-5278 FW denotes et
T7278 5279-5282 FW denotes al.
T7279 5283-5287 CD denotes 1980
T7280 5287-5288 -RRB- denotes )
T7281 5288-5289 . denotes .
T7282 5289-5561 sentence denotes In addition, sequence analysis of the entire Apcs coding region in both strains failed to identify any coding sequence polymorphisms in the Apcs gene (data not shown), indicating that a structural variant of the protein is unlikely to be the explanation for our findings.
T7283 5290-5292 IN denotes In
T7285 5293-5301 NN denotes addition
T7286 5301-5303 , denotes ,
T7287 5303-5311 NN denotes sequence
T7288 5312-5320 NN denotes analysis
T7289 5321-5323 IN denotes of
T7290 5324-5327 DT denotes the
T7292 5328-5334 JJ denotes entire
T7293 5335-5339 NN denotes Apcs
T7294 5340-5346 VBG denotes coding
T7291 5347-5353 NN denotes region
T7295 5354-5356 IN denotes in
T7296 5357-5361 DT denotes both
T7297 5362-5369 NNS denotes strains
T7284 5370-5376 VBD denotes failed
T7298 5377-5379 TO denotes to
T7299 5380-5388 VB denotes identify
T7300 5389-5392 DT denotes any
T7302 5393-5399 VBG denotes coding
T7303 5400-5408 NN denotes sequence
T7301 5409-5422 NNS denotes polymorphisms
T7304 5423-5425 IN denotes in
T7305 5426-5429 DT denotes the
T7307 5430-5434 NN denotes Apcs
T7306 5435-5439 NN denotes gene
T7308 5440-5441 -LRB- denotes (
T7310 5441-5445 NNS denotes data
T7311 5446-5449 RB denotes not
T7309 5450-5455 VBN denotes shown
T7312 5455-5456 -RRB- denotes )
T7313 5456-5458 , denotes ,
T7314 5458-5468 VBG denotes indicating
T7315 5469-5473 IN denotes that
T7317 5474-5475 DT denotes a
T7319 5476-5486 JJ denotes structural
T7318 5487-5494 NN denotes variant
T7320 5495-5497 IN denotes of
T7321 5498-5501 DT denotes the
T7322 5502-5509 NN denotes protein
T7316 5510-5512 VBZ denotes is
T7323 5513-5521 JJ denotes unlikely
T7324 5522-5524 TO denotes to
T7325 5525-5527 VB denotes be
T7326 5528-5531 DT denotes the
T7327 5532-5543 NN denotes explanation
T7328 5544-5547 IN denotes for
T7329 5548-5551 PRP$ denotes our
T7330 5552-5560 NNS denotes findings
T7331 5560-5561 . denotes .
T7332 5561-5735 sentence denotes This is consistent with a previous report by Drake et al. (1996) that showed no Apcs coding sequence differences amongst several autoimmune and nonautoimmune murine strains.
T7333 5562-5566 DT denotes This
T7334 5567-5569 VBZ denotes is
T7335 5570-5580 JJ denotes consistent
T7336 5581-5585 IN denotes with
T7337 5586-5587 DT denotes a
T7339 5588-5596 JJ denotes previous
T7338 5597-5603 NN denotes report
T7340 5604-5606 IN denotes by
T7341 5607-5612 NNP denotes Drake
T7342 5613-5615 FW denotes et
T7343 5616-5619 FW denotes al.
T7344 5620-5621 -LRB- denotes (
T7345 5621-5625 CD denotes 1996
T7346 5625-5626 -RRB- denotes )
T7347 5627-5631 WDT denotes that
T7348 5632-5638 VBD denotes showed
T7349 5639-5641 DT denotes no
T7351 5642-5646 NN denotes Apcs
T7353 5647-5653 VBG denotes coding
T7352 5654-5662 NN denotes sequence
T7350 5663-5674 NNS denotes differences
T7354 5675-5682 IN denotes amongst
T7355 5683-5690 JJ denotes several
T7357 5691-5701 JJ denotes autoimmune
T7358 5702-5705 CC denotes and
T7359 5706-5719 JJ denotes nonautoimmune
T7360 5720-5726 JJ denotes murine
T7356 5727-5734 NNS denotes strains
T7361 5734-5735 . denotes .
T7362 5735-6645 sentence denotes Figure 6 Auto-Ab Profiles (A) ANA titres in the (129 × C57BL/6)F2.Apcs −/− mice and (129 × C57BL/6)F2 at 1 y of age. A small circle represents one mouse; a large circle, a variable number of animals, as indicated in parentheses. Serum samples were titrated to endpoint. (B) ANA titres in the (129 × C57BL/6)F2.Apcs −/− mice and a selected number of wild-type (129 × C57BL/6)F2 animals carrying the Chromosome 1 region between D1Mit105 and D1Mit223 (80–106 cM) of 129 origin. The symbols are as in (A). (C and D) Anti-chromatin Ab levels expressed in AEUs related to a standard positive sample, which was assigned a value of 100 AEU. The comparison is between the same groups of mice as in (A) and (B), respectively. The symbols are as in (A). In addition to the 129-derived segments, in both cohorts the C57BL/6 strain contributed to the autoimmune traits with one major susceptibility locus on Chromosome 3.
T7363 6480-6482 IN denotes In
T7365 6483-6491 NN denotes addition
T7366 6492-6494 IN denotes to
T7367 6495-6498 DT denotes the
T7369 6499-6502 CD denotes 129
T7371 6502-6503 HYPH denotes -
T7370 6503-6510 VBN denotes derived
T7368 6511-6519 NNS denotes segments
T7372 6519-6521 , denotes ,
T7373 6521-6523 IN denotes in
T7374 6524-6528 DT denotes both
T7375 6529-6536 NNS denotes cohorts
T7376 6537-6540 DT denotes the
T7378 6541-6546 NN denotes C57BL
T7379 6546-6547 HYPH denotes /
T7380 6547-6548 CD denotes 6
T7377 6549-6555 NN denotes strain
T7364 6556-6567 VBD denotes contributed
T7381 6568-6570 IN denotes to
T7382 6571-6574 DT denotes the
T7384 6575-6585 JJ denotes autoimmune
T7383 6586-6592 NNS denotes traits
T7385 6593-6597 IN denotes with
T7386 6598-6601 CD denotes one
T7388 6602-6607 JJ denotes major
T7389 6608-6622 NN denotes susceptibility
T7387 6623-6628 NN denotes locus
T7390 6629-6631 IN denotes on
T7391 6632-6642 NN denotes Chromosome
T7392 6643-6644 CD denotes 3
T7393 6644-6645 . denotes .
T7394 6645-6883 sentence denotes A genomic region between D3Mit40 and D3Mit13, with an estimated peak at position approximately 51 cM, showed a significant linkage to ANA production and weaker linkages to anti-ssDNA and anti-chromatin production (see Table 3; Figure 7).
T7395 6646-6647 DT denotes A
T7397 6648-6655 JJ denotes genomic
T7396 6656-6662 NN denotes region
T7399 6663-6670 IN denotes between
T7400 6671-6678 NN denotes D3Mit40
T7401 6679-6682 CC denotes and
T7402 6683-6690 NN denotes D3Mit13
T7403 6690-6692 , denotes ,
T7404 6692-6696 IN denotes with
T7405 6697-6699 DT denotes an
T7407 6700-6709 VBN denotes estimated
T7406 6710-6714 NN denotes peak
T7408 6715-6717 IN denotes at
T7409 6718-6726 NN denotes position
T7411 6727-6740 RB denotes approximately
T7412 6741-6743 CD denotes 51
T7410 6744-6746 NNS denotes cM
T7413 6746-6748 , denotes ,
T7398 6748-6754 VBD denotes showed
T7414 6755-6756 DT denotes a
T7416 6757-6768 JJ denotes significant
T7415 6769-6776 NN denotes linkage
T7417 6777-6779 IN denotes to
T7418 6780-6783 NN denotes ANA
T7419 6784-6794 NN denotes production
T7420 6795-6798 CC denotes and
T7421 6799-6805 JJR denotes weaker
T7422 6806-6814 NNS denotes linkages
T7423 6815-6817 IN denotes to
T7424 6818-6828 JJ denotes anti-ssDNA
T7426 6829-6832 CC denotes and
T7427 6833-6847 JJ denotes anti-chromatin
T7425 6848-6858 NN denotes production
T7428 6859-6860 -LRB- denotes (
T7429 6860-6863 VB denotes see
T7430 6864-6869 NN denotes Table
T7431 6870-6871 CD denotes 3
T7432 6871-6872 : denotes ;
T7433 6873-6879 NN denotes Figure
T7434 6880-6881 CD denotes 7
T7435 6881-6882 -RRB- denotes )
T7436 6882-6883 . denotes .
T7437 6883-7153 sentence denotes The high frequency of autoimmune phenotype in the (129 × C57BL/6) hybrid genetic background and its absence in either of the inbred parental strains imply that there are essential interactions between 129- and C57BL/6-derived alleles for the expression of autoimmunity.
T7438 6884-6887 DT denotes The
T7440 6888-6892 JJ denotes high
T7439 6893-6902 NN denotes frequency
T7442 6903-6905 IN denotes of
T7443 6906-6916 JJ denotes autoimmune
T7444 6917-6926 NN denotes phenotype
T7445 6927-6929 IN denotes in
T7446 6930-6933 DT denotes the
T7448 6934-6935 -LRB- denotes (
T7449 6935-6938 CD denotes 129
T7450 6939-6940 SYM denotes ×
T7451 6941-6946 NN denotes C57BL
T7452 6946-6947 HYPH denotes /
T7453 6947-6948 CD denotes 6
T7454 6948-6949 -RRB- denotes )
T7455 6950-6956 JJ denotes hybrid
T7456 6957-6964 JJ denotes genetic
T7447 6965-6975 NN denotes background
T7457 6976-6979 CC denotes and
T7458 6980-6983 PRP$ denotes its
T7459 6984-6991 NN denotes absence
T7460 6992-6994 IN denotes in
T7461 6995-7001 DT denotes either
T7462 7002-7004 IN denotes of
T7463 7005-7008 DT denotes the
T7465 7009-7015 JJ denotes inbred
T7466 7016-7024 JJ denotes parental
T7464 7025-7032 NNS denotes strains
T7441 7033-7038 VBP denotes imply
T7467 7039-7043 IN denotes that
T7469 7044-7049 EX denotes there
T7468 7050-7053 VBP denotes are
T7470 7054-7063 JJ denotes essential
T7471 7064-7076 NNS denotes interactions
T7472 7077-7084 IN denotes between
T7473 7085-7088 CD denotes 129
T7475 7088-7089 HYPH denotes -
T7476 7090-7093 CC denotes and
T7477 7094-7099 NN denotes C57BL
T7478 7099-7100 HYPH denotes /
T7479 7100-7101 CD denotes 6
T7480 7101-7102 HYPH denotes -
T7474 7102-7109 VBN denotes derived
T7481 7110-7117 NNS denotes alleles
T7482 7118-7121 IN denotes for
T7483 7122-7125 DT denotes the
T7484 7126-7136 NN denotes expression
T7485 7137-7139 IN denotes of
T7486 7140-7152 NN denotes autoimmunity
T7487 7152-7153 . denotes .
T7488 7153-7398 sentence denotes We investigated further the effects of genes from the C57BL/6 background by repeating the linkage analysis in (129 × C57BL/6)F2 mice, whilst controlling for the very strong 129 effect on distal Chromosome 1, as previously described (Zeng 1994).
T7489 7154-7156 PRP denotes We
T7490 7157-7169 VBD denotes investigated
T7491 7170-7177 RB denotes further
T7492 7178-7181 DT denotes the
T7493 7182-7189 NNS denotes effects
T7494 7190-7192 IN denotes of
T7495 7193-7198 NNS denotes genes
T7496 7199-7203 IN denotes from
T7497 7204-7207 DT denotes the
T7499 7208-7213 NN denotes C57BL
T7500 7213-7214 HYPH denotes /
T7501 7214-7215 CD denotes 6
T7498 7216-7226 NN denotes background
T7502 7227-7229 IN denotes by
T7503 7230-7239 VBG denotes repeating
T7504 7240-7243 DT denotes the
T7506 7244-7251 NN denotes linkage
T7505 7252-7260 NN denotes analysis
T7507 7261-7263 IN denotes in
T7508 7264-7265 -LRB- denotes (
T7510 7265-7268 CD denotes 129
T7511 7269-7270 SYM denotes ×
T7512 7271-7276 NN denotes C57BL
T7513 7276-7277 HYPH denotes /
T7514 7277-7278 CD denotes 6
T7515 7278-7279 -RRB- denotes )
T7516 7279-7281 NN denotes F2
T7509 7282-7286 NNS denotes mice
T7517 7286-7288 , denotes ,
T7518 7288-7294 IN denotes whilst
T7519 7295-7306 VBG denotes controlling
T7520 7307-7310 IN denotes for
T7521 7311-7314 DT denotes the
T7523 7315-7319 RB denotes very
T7524 7320-7326 JJ denotes strong
T7525 7327-7330 CD denotes 129
T7522 7331-7337 NN denotes effect
T7526 7338-7340 IN denotes on
T7527 7341-7347 JJ denotes distal
T7528 7348-7358 NN denotes Chromosome
T7529 7359-7360 CD denotes 1
T7530 7360-7362 , denotes ,
T7531 7362-7364 IN denotes as
T7533 7365-7375 RB denotes previously
T7532 7376-7385 VBN denotes described
T7534 7386-7387 -LRB- denotes (
T7535 7387-7391 NNP denotes Zeng
T7536 7392-7396 CD denotes 1994
T7537 7396-7397 -RRB- denotes )
T7538 7397-7398 . denotes .
T7539 7398-7579 sentence denotes The results of this analysis showed that the statistical support for the linkage of the C57BL/6 locus on Chromosome 3 for ANA increased from logarithm of odds (LOD) 5.4 to LOD 6.4.
T7540 7399-7402 DT denotes The
T7541 7403-7410 NNS denotes results
T7543 7411-7413 IN denotes of
T7544 7414-7418 DT denotes this
T7545 7419-7427 NN denotes analysis
T7542 7428-7434 VBD denotes showed
T7546 7435-7439 IN denotes that
T7548 7440-7443 DT denotes the
T7550 7444-7455 JJ denotes statistical
T7549 7456-7463 NN denotes support
T7551 7464-7467 IN denotes for
T7552 7468-7471 DT denotes the
T7553 7472-7479 NN denotes linkage
T7554 7480-7482 IN denotes of
T7555 7483-7486 DT denotes the
T7557 7487-7492 NN denotes C57BL
T7558 7492-7493 HYPH denotes /
T7559 7493-7494 CD denotes 6
T7556 7495-7500 NN denotes locus
T7560 7501-7503 IN denotes on
T7561 7504-7514 NN denotes Chromosome
T7562 7515-7516 CD denotes 3
T7563 7517-7520 IN denotes for
T7564 7521-7524 NN denotes ANA
T7547 7525-7534 VBD denotes increased
T7565 7535-7539 IN denotes from
T7566 7540-7549 NN denotes logarithm
T7567 7550-7552 IN denotes of
T7568 7553-7557 NNS denotes odds
T7569 7558-7559 -LRB- denotes (
T7570 7559-7562 NN denotes LOD
T7571 7562-7563 -RRB- denotes )
T7572 7564-7567 CD denotes 5.4
T7573 7568-7570 IN denotes to
T7574 7571-7574 NN denotes LOD
T7575 7575-7578 CD denotes 6.4
T7576 7578-7579 . denotes .
T7577 7579-8615 sentence denotes Figure 7 Interval Mapping Scans Showing QTL on Chromosome 3 with ANA, Anti-Chromatin, and Anti-ssDNA Abs See Table 3 for additional details. Centimorgan positions were deduced by interval mapping, anchoring marker locations to data from http://www.informatics.jax.org. Dotted lines indicate the threshold over which linkage was considered suggestive, the dashed line indicate the threshold over which linkage was considered significant, and dotted/dashed lines indicate highly significant linkage, as defined in Materials and Methods. In contrast to these strong associations with disease serological markers, the QTL analysis identified only two potential linkages to glomerulonephritis: one in the wild-type mice on Chromosome 7 across a 10 cM region between D7Mit246 (15 cM) and D7Mit145 (26.5 cM) of 129 origin (LOD 2.86, p = 0.0013), and one on Chromosome 17 between D17Mit100 (11.7 cM) and D17Mit216 (29.4 cM) from the C57BL/6 strain (LOD 1.3, p = 0.049 and LOD 1.67, p = 0.021 in the wild-type and Apcs −/− mice, respectively).
T7578 8116-8118 IN denotes In
T7580 8119-8127 NN denotes contrast
T7581 8128-8130 IN denotes to
T7582 8131-8136 DT denotes these
T7584 8137-8143 JJ denotes strong
T7583 8144-8156 NNS denotes associations
T7585 8157-8161 IN denotes with
T7586 8162-8169 NN denotes disease
T7588 8170-8181 JJ denotes serological
T7587 8182-8189 NNS denotes markers
T7589 8189-8191 , denotes ,
T7590 8191-8194 DT denotes the
T7592 8195-8198 NN denotes QTL
T7591 8199-8207 NN denotes analysis
T7579 8208-8218 VBD denotes identified
T7593 8219-8223 RB denotes only
T7595 8224-8227 CD denotes two
T7596 8228-8237 JJ denotes potential
T7594 8238-8246 NNS denotes linkages
T7597 8247-8249 IN denotes to
T7598 8250-8268 NN denotes glomerulonephritis
T7599 8268-8270 : denotes :
T7600 8270-8273 CD denotes one
T7601 8274-8276 IN denotes in
T7602 8277-8280 DT denotes the
T7604 8281-8285 JJ denotes wild
T7606 8285-8286 HYPH denotes -
T7605 8286-8290 NN denotes type
T7603 8291-8295 NNS denotes mice
T7607 8296-8298 IN denotes on
T7608 8299-8309 NN denotes Chromosome
T7609 8310-8311 CD denotes 7
T7610 8312-8318 IN denotes across
T7611 8319-8320 DT denotes a
T7613 8321-8323 CD denotes 10
T7614 8324-8326 NN denotes cM
T7612 8327-8333 NN denotes region
T7615 8334-8341 IN denotes between
T7616 8342-8350 NN denotes D7Mit246
T7617 8351-8352 -LRB- denotes (
T7619 8352-8354 CD denotes 15
T7618 8355-8357 NN denotes cM
T7620 8357-8358 -RRB- denotes )
T7621 8359-8362 CC denotes and
T7622 8363-8371 NN denotes D7Mit145
T7623 8372-8373 -LRB- denotes (
T7625 8373-8377 CD denotes 26.5
T7624 8378-8380 NN denotes cM
T7626 8380-8381 -RRB- denotes )
T7627 8382-8384 IN denotes of
T7628 8385-8388 CD denotes 129
T7629 8389-8395 NN denotes origin
T7630 8396-8397 -LRB- denotes (
T7631 8397-8400 NN denotes LOD
T7632 8401-8405 CD denotes 2.86
T7633 8405-8407 , denotes ,
T7634 8407-8408 NN denotes p
T7636 8409-8410 SYM denotes =
T7635 8411-8417 CD denotes 0.0013
T7637 8417-8418 -RRB- denotes )
T7638 8418-8420 , denotes ,
T7639 8420-8423 CC denotes and
T7640 8424-8427 CD denotes one
T7641 8428-8430 IN denotes on
T7642 8431-8441 NN denotes Chromosome
T7643 8442-8444 CD denotes 17
T7644 8445-8452 IN denotes between
T7645 8453-8462 NN denotes D17Mit100
T7646 8463-8464 -LRB- denotes (
T7648 8464-8468 CD denotes 11.7
T7647 8469-8471 NN denotes cM
T7649 8471-8472 -RRB- denotes )
T7650 8473-8476 CC denotes and
T7651 8477-8486 NN denotes D17Mit216
T7652 8487-8488 -LRB- denotes (
T7654 8488-8492 CD denotes 29.4
T7653 8493-8495 NN denotes cM
T7655 8495-8496 -RRB- denotes )
T7656 8497-8501 IN denotes from
T7657 8502-8505 DT denotes the
T7659 8506-8511 NN denotes C57BL
T7660 8511-8512 HYPH denotes /
T7661 8512-8513 CD denotes 6
T7658 8514-8520 NN denotes strain
T7662 8521-8522 -LRB- denotes (
T7664 8522-8525 NN denotes LOD
T7665 8526-8529 CD denotes 1.3
T7666 8529-8531 , denotes ,
T7667 8531-8532 NN denotes p
T7668 8533-8534 SYM denotes =
T7663 8535-8540 CD denotes 0.049
T7669 8541-8544 CC denotes and
T7670 8545-8548 NN denotes LOD
T7672 8549-8553 CD denotes 1.67
T7673 8553-8555 , denotes ,
T7674 8555-8556 NN denotes p
T7675 8557-8558 SYM denotes =
T7671 8559-8564 CD denotes 0.021
T7676 8565-8567 IN denotes in
T7677 8568-8571 DT denotes the
T7679 8572-8576 JJ denotes wild
T7681 8576-8577 HYPH denotes -
T7680 8577-8581 NN denotes type
T7682 8582-8585 CC denotes and
T7683 8586-8590 NN denotes Apcs
T7684 8591-8592 SYM denotes −
T7685 8592-8593 HYPH denotes /
T7686 8593-8594 SYM denotes −
T7678 8595-8599 NNS denotes mice
T7687 8599-8601 , denotes ,
T7688 8601-8613 RB denotes respectively
T7689 8613-8614 -RRB- denotes )
T7690 8614-8615 . denotes .
T7691 8615-8791 sentence denotes Histological evidence of glomerulonephritis was only found in approximately 20% of the mice in each cohort, which reduces the power of the QTL analysis for this disease trait.
T7692 8616-8628 JJ denotes Histological
T7693 8629-8637 NN denotes evidence
T7695 8638-8640 IN denotes of
T7696 8641-8659 NN denotes glomerulonephritis
T7697 8660-8663 VBD denotes was
T7698 8664-8668 RB denotes only
T7694 8669-8674 VBN denotes found
T7699 8675-8677 IN denotes in
T7700 8678-8691 RB denotes approximately
T7701 8692-8694 CD denotes 20
T7702 8694-8695 NN denotes %
T7703 8696-8698 IN denotes of
T7704 8699-8702 DT denotes the
T7705 8703-8707 NNS denotes mice
T7706 8708-8710 IN denotes in
T7707 8711-8715 DT denotes each
T7708 8716-8722 NN denotes cohort
T7709 8722-8724 , denotes ,
T7710 8724-8729 WDT denotes which
T7711 8730-8737 VBZ denotes reduces
T7712 8738-8741 DT denotes the
T7713 8742-8747 NN denotes power
T7714 8748-8750 IN denotes of
T7715 8751-8754 DT denotes the
T7717 8755-8758 NN denotes QTL
T7716 8759-8767 NN denotes analysis
T7718 8768-8771 IN denotes for
T7719 8772-8776 DT denotes this
T7721 8777-8784 NN denotes disease
T7720 8785-8790 NN denotes trait
T7722 8790-8791 . denotes .
R1568 T6733 T6732 prep of,Mapping
R1569 T6734 T6733 pobj Loci,of
R1570 T6735 T6734 acl Predisposing,Loci
R1571 T6736 T6735 prep to,Predisposing
R1572 T6737 T6736 pobj Lupus,to
R1573 T6738 T6732 prep in,Mapping
R1574 T6739 T6740 det the,Strain
R1575 T6740 T6738 pobj Strain,in
R1576 T6741 T6740 compound Hybrid,Strain
R1577 T6742 T6740 punct (,Strain
R1578 T6743 T6740 appos 129,Strain
R1579 T6744 T6743 punct ×,129
R1580 T6745 T6743 appos C57BL,129
R1581 T6746 T6745 punct /,C57BL
R1582 T6747 T6745 nummod 6,C57BL
R1583 T6748 T6740 punct ),Strain
R1584 T6750 T6751 nsubjpass Mice,genotyped
R1585 T6752 T6751 auxpass were,genotyped
R1586 T6753 T6751 prep with,genotyped
R1587 T6754 T6755 nummod 143,markers
R1588 T6755 T6753 pobj markers,with
R1589 T6756 T6755 compound microsatellite,markers
R1590 T6757 T6755 acl distributed,markers
R1591 T6758 T6757 prep throughout,distributed
R1592 T6759 T6760 det the,autosomes
R1593 T6760 T6758 pobj autosomes,throughout
R1594 T6761 T6762 amod such,were
R1595 T6762 T6751 advcl were,genotyped
R1596 T6763 T6762 mark that,were
R1597 T6764 T6765 nummod 98,%
R1598 T6765 T6762 nsubj %,were
R1599 T6766 T6765 prep of,%
R1600 T6767 T6768 det the,genes
R1601 T6768 T6766 pobj genes,of
R1602 T6769 T6762 prep within,were
R1603 T6770 T6771 nummod 20,cM
R1604 T6771 T6769 pobj cM,within
R1605 T6772 T6771 prep of,cM
R1606 T6773 T6774 det an,marker
R1607 T6774 T6772 pobj marker,of
R1608 T6775 T6774 amod informative,marker
R1609 T6776 T6751 punct .,genotyped
R1610 T6778 T6779 det A,summary
R1611 T6779 T6780 nsubjpass summary,shown
R1612 T6781 T6779 prep of,summary
R1613 T6782 T6783 det the,analysis
R1614 T6783 T6781 pobj analysis,of
R1615 T6784 T6785 npadvmod genome,wide
R1616 T6785 T6783 amod wide,analysis
R1617 T6786 T6785 punct -,wide
R1618 T6787 T6783 compound linkage,analysis
R1619 T6788 T6779 prep for,summary
R1620 T6789 T6788 pobj each,for
R1621 T6790 T6789 prep of,each
R1622 T6791 T6792 det the,traits
R1623 T6792 T6790 pobj traits,of
R1624 T6793 T6792 compound disease,traits
R1625 T6794 T6792 acl measured,traits
R1626 T6795 T6780 auxpass is,shown
R1627 T6796 T6780 prep in,shown
R1628 T6797 T6796 pobj Table,in
R1629 T6798 T6797 nummod 3,Table
R1630 T6799 T6780 punct .,shown
R1631 T6801 T6802 det The,areas
R1632 T6802 T6803 nsubjpass areas,defined
R1633 T6804 T6802 prep of,areas
R1634 T6805 T6804 pobj linkage,of
R1635 T6806 T6803 auxpass were,defined
R1636 T6807 T6803 prep according,defined
R1637 T6808 T6807 prep to,according
R1638 T6809 T6810 det the,origin
R1639 T6810 T6808 pobj origin,to
R1640 T6811 T6810 amod parental,origin
R1641 T6812 T6810 punct ", ",origin
R1642 T6813 T6810 appos 129,origin
R1643 T6814 T6813 cc or,129
R1644 T6815 T6813 conj C57BL,129
R1645 T6816 T6815 punct /,C57BL
R1646 T6817 T6815 nummod 6,C57BL
R1647 T6818 T6803 punct .,defined
R1648 T6820 T6821 advmod Only,linkages
R1649 T6821 T6822 nsubjpass linkages,reported
R1650 T6823 T6821 acl identified,linkages
R1651 T6824 T6823 prep in,identified
R1652 T6825 T6826 det both,groups
R1653 T6826 T6824 pobj groups,in
R1654 T6827 T6826 amod experimental,groups
R1655 T6828 T6822 auxpass are,reported
R1656 T6829 T6822 prep in,reported
R1657 T6830 T6829 pobj Table,in
R1658 T6831 T6830 nummod 3,Table
R1659 T6832 T6822 punct ", ",reported
R1660 T6833 T6822 prep with,reported
R1661 T6834 T6835 det the,exception
R1662 T6835 T6833 pobj exception,with
R1663 T6836 T6835 prep of,exception
R1664 T6837 T6838 det the,segment
R1665 T6838 T6836 pobj segment,of
R1666 T6839 T6838 nmod Chromosome,segment
R1667 T6840 T6839 nummod 1,Chromosome
R1668 T6841 T6838 amod distal,segment
R1669 T6842 T6838 punct ", ",segment
R1670 T6843 T6844 advmod where,applied
R1671 T6844 T6838 relcl applied,segment
R1672 T6845 T6846 det the,analysis
R1673 T6846 T6844 nsubjpass analysis,applied
R1674 T6847 T6846 compound linkage,analysis
R1675 T6848 T6844 aux could,applied
R1676 T6849 T6844 neg not,applied
R1677 T6850 T6844 auxpass be,applied
R1678 T6851 T6844 prep to,applied
R1679 T6852 T6853 det the,mice
R1680 T6853 T6851 pobj mice,to
R1681 T6854 T6855 punct (,F2
R1682 T6855 T6853 nmod F2,mice
R1683 T6856 T6855 nummod 129,F2
R1684 T6857 T6856 punct ×,129
R1685 T6858 T6856 appos C57BL,129
R1686 T6859 T6858 punct /,C57BL
R1687 T6860 T6858 nummod 6,C57BL
R1688 T6861 T6855 punct ),F2
R1689 T6862 T6855 punct .,F2
R1690 T6863 T6855 appos Apcs,F2
R1691 T6864 T6863 punct −,Apcs
R1692 T6865 T6863 punct /,Apcs
R1693 T6866 T6863 punct −,Apcs
R1694 T6867 T6868 mark as,was
R1695 T6868 T6844 advcl was,applied
R1696 T6869 T6870 det this,region
R1697 T6870 T6868 nsubj region,was
R1698 T6871 T6868 prep of,was
R1699 T6872 T6873 amod fixed,origin
R1700 T6873 T6871 pobj origin,of
R1701 T6874 T6873 nummod 129,origin
R1702 T6875 T6822 punct .,reported
R1703 T6877 T6878 nsubjpass Chromosomes,shown
R1704 T6879 T6880 advmod where,were
R1705 T6880 T6877 relcl were,Chromosomes
R1706 T6881 T6880 nsubj linkages,were
R1707 T6882 T6880 acomp present,were
R1708 T6883 T6884 advmod only,in
R1709 T6884 T6880 prep in,were
R1710 T6885 T6884 pobj one,in
R1711 T6886 T6885 prep of,one
R1712 T6887 T6888 det the,cohorts
R1713 T6888 T6886 pobj cohorts,of
R1714 T6889 T6888 nummod two,cohorts
R1715 T6890 T6878 auxpass are,shown
R1716 T6891 T6878 prep in,shown
R1717 T6892 T6893 nmod Figures,1
R1718 T6893 T6891 pobj 1,in
R1719 T6894 T6895 punct –,3
R1720 T6895 T6893 prep 3,1
R1721 T6896 T6878 punct .,shown
R1722 T6898 T6899 det The,analysis
R1723 T6899 T6906 nsubj analysis,identified
R1724 T6900 T6901 amod quantitative,linkage
R1725 T6901 T6899 nmod linkage,analysis
R1726 T6902 T6901 nmod trait,linkage
R1727 T6903 T6901 punct (,linkage
R1728 T6904 T6901 appos QTL,linkage
R1729 T6905 T6901 punct ),linkage
R1730 T6907 T6908 amod several,intervals
R1731 T6908 T6906 dobj intervals,identified
R1732 T6909 T6908 prep on,intervals
R1733 T6910 T6909 pobj Chromosome,on
R1734 T6911 T6910 nummod 1,Chromosome
R1735 T6912 T6908 prep with,intervals
R1736 T6913 T6912 pobj linkage,with
R1737 T6914 T6913 prep to,linkage
R1738 T6915 T6916 nmod disease,markers
R1739 T6916 T6914 pobj markers,to
R1740 T6917 T6916 amod serological,markers
R1741 T6918 T6906 punct ", ",identified
R1742 T6919 T6906 cc and,identified
R1743 T6920 T6921 det these,regions
R1744 T6921 T6922 nsubjpass regions,derived
R1745 T6922 T6906 conj derived,identified
R1746 T6923 T6922 auxpass were,derived
R1747 T6924 T6922 advmod all,derived
R1748 T6925 T6922 prep from,derived
R1749 T6926 T6927 det the,strain
R1750 T6927 T6925 pobj strain,from
R1751 T6928 T6927 nummod 129,strain
R1752 T6929 T6927 compound mouse,strain
R1753 T6930 T6931 punct (,4
R1754 T6931 T6922 parataxis 4,derived
R1755 T6932 T6931 advcl see,4
R1756 T6933 T6932 dobj Table,see
R1757 T6934 T6933 nummod 3,Table
R1758 T6935 T6931 punct ;,4
R1759 T6936 T6931 nmod Figures,4
R1760 T6937 T6931 cc and,4
R1761 T6938 T6931 conj 5,4
R1762 T6939 T6931 punct ),4
R1763 T6940 T6922 punct .,derived
R1764 T6942 T6943 advmod Interestingly,linked
R1765 T6944 T6943 punct ", ",linked
R1766 T6945 T6946 mark whilst,showed
R1767 T6946 T6943 advcl showed,linked
R1768 T6947 T6948 nmod ANA,levels
R1769 T6948 T6946 nsubj levels,showed
R1770 T6949 T6947 cc and,ANA
R1771 T6950 T6951 amod anti-chromatin,Ab
R1772 T6951 T6947 conj Ab,ANA
R1773 T6952 T6953 amod suggestive,linkages
R1774 T6953 T6946 dobj linkages,showed
R1775 T6954 T6952 cc or,suggestive
R1776 T6955 T6952 conj significant,suggestive
R1777 T6956 T6957 advmod only,to
R1778 T6957 T6953 prep to,linkages
R1779 T6958 T6959 det the,region
R1780 T6959 T6957 pobj region,to
R1781 T6960 T6959 amod telomeric,region
R1782 T6961 T6959 prep of,region
R1783 T6962 T6961 pobj Chromosome,of
R1784 T6963 T6962 nummod 1,Chromosome
R1785 T6964 T6953 punct ", ",linkages
R1786 T6965 T6953 prep with,linkages
R1787 T6966 T6967 det an,peak
R1788 T6967 T6969 nsubj peak,occurring
R1789 T6968 T6967 amod estimated,peak
R1790 T6969 T6965 pcomp occurring,with
R1791 T6970 T6969 prep at,occurring
R1792 T6971 T6972 det a,position
R1793 T6972 T6970 pobj position,at
R1794 T6973 T6974 advmod approximately,90
R1795 T6974 T6975 nummod 90,cM
R1796 T6975 T6976 npadvmod cM,near
R1797 T6976 T6972 prep near,position
R1798 T6977 T6978 det the,gene
R1799 T6978 T6976 pobj gene,near
R1800 T6979 T6978 compound Apcs,gene
R1801 T6980 T6943 punct ", ",linked
R1802 T6981 T6982 amod anti-dsDNA,production
R1803 T6982 T6943 nsubjpass production,linked
R1804 T6983 T6981 cc or,anti-dsDNA
R1805 T6984 T6981 conj anti-ssDNA,anti-dsDNA
R1806 T6985 T6982 compound Ab,production
R1807 T6986 T6943 auxpass was,linked
R1808 T6987 T6943 advmod also,linked
R1809 T6988 T6943 prep to,linked
R1810 T6989 T6990 amod other,segments
R1811 T6990 T6988 pobj segments,to
R1812 T6991 T6990 prep on,segments
R1813 T6992 T6991 pobj Chromosome,on
R1814 T6993 T6992 nummod 1,Chromosome
R1815 T6994 T6943 punct ", ",linked
R1816 T6995 T6943 advcl indicating,linked
R1817 T6996 T6997 det a,contribution
R1818 T6997 T6995 dobj contribution,indicating
R1819 T6998 T6999 advmod more,complex
R1820 T6999 T6997 amod complex,contribution
R1821 T7000 T6997 amod genetic,contribution
R1822 T7001 T6995 prep from,indicating
R1823 T7002 T7003 det the,strain
R1824 T7003 T7001 pobj strain,from
R1825 T7004 T7003 nummod 129,strain
R1826 T7005 T7003 compound mouse,strain
R1827 T7006 T6943 punct .,linked
R1828 T7008 T7009 advcl Guided,investigated
R1829 T7010 T7008 agent by,Guided
R1830 T7011 T7012 det these,observations
R1831 T7012 T7010 pobj observations,by
R1832 T7013 T7009 punct ", ",investigated
R1833 T7014 T7009 nsubj we,investigated
R1834 T7015 T7016 mark whether,caused
R1835 T7016 T7009 ccomp caused,investigated
R1836 T7017 T7018 det the,levels
R1837 T7018 T7016 nsubjpass levels,caused
R1838 T7019 T7018 amod increased,levels
R1839 T7020 T7018 prep of,levels
R1840 T7021 T7020 pobj ANA,of
R1841 T7022 T7021 cc and,ANA
R1842 T7023 T7024 amod anti-chromatin,Ab
R1843 T7024 T7021 conj Ab,ANA
R1844 T7025 T7018 acl observed,levels
R1845 T7026 T7025 prep in,observed
R1846 T7027 T7028 det the,mice
R1847 T7028 T7026 pobj mice,in
R1848 T7029 T7028 nmod Apcs,mice
R1849 T7030 T7029 punct −,Apcs
R1850 T7031 T7029 punct /,Apcs
R1851 T7032 T7029 punct −,Apcs
R1852 T7033 T7016 auxpass were,caused
R1853 T7034 T7016 agent by,caused
R1854 T7035 T7036 det a,gene
R1855 T7036 T7034 pobj gene,by
R1856 T7037 T7036 punct (,gene
R1857 T7038 T7036 nmod s,gene
R1858 T7039 T7036 punct ),gene
R1859 T7040 T7036 prep within,gene
R1860 T7041 T7042 det the,region
R1861 T7042 T7040 pobj region,within
R1862 T7043 T7042 amod fixed,region
R1863 T7044 T7042 nummod 129,region
R1864 T7045 T7042 acl surrounding,region
R1865 T7046 T7047 det the,gene
R1866 T7047 T7045 dobj gene,surrounding
R1867 T7048 T7047 amod mutated,gene
R1868 T7049 T7047 compound Apcs,gene
R1869 T7050 T7016 punct ", ",caused
R1870 T7051 T7052 advmod rather,than
R1871 T7052 T7016 cc than,caused
R1872 T7053 T7016 conj caused,caused
R1873 T7054 T7053 agent by,caused
R1874 T7055 T7056 det the,gene
R1875 T7056 T7054 pobj gene,by
R1876 T7057 T7056 amod mutated,gene
R1877 T7058 T7056 compound Apcs,gene
R1878 T7059 T7056 appos itself,gene
R1879 T7060 T7009 punct .,investigated
R1880 T7062 T7063 nsubj We,compared
R1881 T7064 T7065 det the,levels
R1882 T7065 T7063 dobj levels,compared
R1883 T7066 T7065 prep of,levels
R1884 T7067 T7068 det these,auto-Abs
R1885 T7068 T7066 pobj auto-Abs,of
R1886 T7069 T7065 prep between,levels
R1887 T7070 T7071 det all,mice
R1888 T7071 T7069 pobj mice,between
R1889 T7072 T7071 punct (,mice
R1890 T7073 T7074 nummod 129,F2
R1891 T7074 T7071 nmod F2,mice
R1892 T7075 T7073 punct ×,129
R1893 T7076 T7073 appos C57BL,129
R1894 T7077 T7076 punct /,C57BL
R1895 T7078 T7076 nummod 6,C57BL
R1896 T7079 T7074 punct ),F2
R1897 T7080 T7074 punct .,F2
R1898 T7081 T7074 appos Apcs,F2
R1899 T7082 T7081 punct −,Apcs
R1900 T7083 T7081 punct /,Apcs
R1901 T7084 T7081 punct −,Apcs
R1902 T7085 T7071 cc and,mice
R1903 T7086 T7087 det a,group
R1904 T7087 T7071 conj group,mice
R1905 T7088 T7087 prep of,group
R1906 T7089 T7090 nummod 33,mice
R1907 T7090 T7088 pobj mice,of
R1908 T7091 T7092 amod wild,type
R1909 T7092 T7090 compound type,mice
R1910 T7093 T7092 punct -,type
R1911 T7094 T7095 dep that,selected
R1912 T7095 T7090 relcl selected,mice
R1913 T7096 T7095 auxpass were,selected
R1914 T7097 T7095 prep for,selected
R1915 T7098 T7097 pcomp being,for
R1916 T7099 T7100 amod homozygous,129
R1917 T7100 T7098 attr 129,being
R1918 T7101 T7098 prep in,being
R1919 T7102 T7103 det the,region
R1920 T7209 T7212 dep mg,16
R1921 T7210 T7209 punct ", ",mg
R1922 T7211 T7209 nummod 83,mg
R1923 T7212 T7207 dep 16,0.0001
R1924 T7213 T7214 punct /,l
R1925 T7214 T7209 prep l,mg
R1926 T7215 T7212 punct ;,16
R1927 T7216 T7217 dep range,25
R1928 T7217 T7212 dep 25,16
R1929 T7218 T7217 punct ", ",25
R1930 T7219 T7220 punct –,208
R1931 T7220 T7217 prep 208,25
R1932 T7221 T7212 punct ;,16
R1933 T7222 T7212 nsubj n,16
R1934 T7223 T7212 punct =,16
R1935 T7224 T7212 cc versus,16
R1936 T7225 T7226 dep median,mg
R1937 T7226 T7229 dep mg,10
R1938 T7227 T7226 punct ", ",mg
R1939 T7228 T7226 nummod 5,mg
R1940 T7103 T7101 pobj region,in
R1941 T7229 T7241 dep 10,respectively
R1942 T7104 T7103 prep of,region
R1943 T7230 T7231 punct /,l
R1944 T7105 T7104 pobj Chromosome,of
R1945 T7106 T7105 nummod 1,Chromosome
R1946 T7231 T7226 prep l,mg
R1947 T7107 T7103 prep between,region
R1948 T7108 T7109 compound microsatellites,D1Mit105
R1949 T7109 T7107 pobj D1Mit105,between
R1950 T7232 T7229 punct ;,10
R1951 T7110 T7109 cc and,D1Mit105
R1952 T7111 T7109 conj D1Mit,D1Mit105
R1953 T7233 T7234 dep range,4
R1954 T7112 T7111 nummod 223,D1Mit
R1955 T7113 T7114 punct (,cM
R1956 T7234 T7229 dep 4,10
R1957 T7114 T7103 parataxis cM,region
R1958 T7115 T7116 quantmod 80,106
R1959 T7116 T7114 nummod 106,cM
R1960 T7235 T7234 punct ", ",4
R1961 T7117 T7116 punct –,106
R1962 T7118 T7114 punct ),cM
R1963 T7119 T7120 punct (,6A
R1964 T7236 T7237 punct –,9
R1965 T7120 T7063 parataxis 6A,compared
R1966 T7121 T7120 compound Figure,6A
R1967 T7237 T7234 prep 9,4
R1968 T7122 T7123 punct –,6D
R1969 T7123 T7120 prep 6D,6A
R1970 T7124 T7120 punct ),6A
R1971 T7238 T7229 punct ;,10
R1972 T7125 T7063 punct .,compared
R1973 T7239 T7229 nsubj n,10
R1974 T7127 T7128 prep In,showed
R1975 T7240 T7229 punct =,10
R1976 T7129 T7127 pobj contrast,In
R1977 T7130 T7129 prep to,contrast
R1978 T7131 T7132 det the,results
R1979 T7241 T7212 conj respectively,16
R1980 T7132 T7130 pobj results,to
R1981 T7133 T7132 acl reported,results
R1982 T7134 T7133 prep in,reported
R1983 T7242 T7229 punct ", ",10
R1984 T7135 T7134 pobj Table,in
R1985 T7136 T7135 nummod 1,Table
R1986 T7137 T7128 punct ", ",showed
R1987 T7138 T7139 det this,comparison
R1988 T7243 T7207 punct ;,0.0001
R1989 T7244 T7207 nsubj p,0.0001
R1990 T7139 T7128 nsubj comparison,showed
R1991 T7140 T7141 det no,differences
R1992 T7245 T7207 punct <,0.0001
R1993 T7141 T7128 dobj differences,showed
R1994 T7142 T7141 amod significant,differences
R1995 T7246 T7207 punct ),0.0001
R1996 T7143 T7141 prep between,differences
R1997 T7144 T7145 det the,groups
R1998 T7247 T7181 punct .,found
R1999 T7145 T7143 pobj groups,between
R2000 T7146 T7145 nummod two,groups
R2001 T7147 T7145 amod experimental,groups
R2002 T7249 T7250 det The,strain
R2003 T7148 T7128 punct .,showed
R2004 T7150 T7151 det This,result
R2005 T7250 T7254 nsubjpass strain,reported
R2006 T7151 T7152 nsubj result,demonstrates
R2007 T7251 T7250 nmod C57BL,strain
R2008 T7153 T7154 mark that,mediating
R2009 T7154 T7152 ccomp mediating,demonstrates
R2010 T7252 T7251 punct /,C57BL
R2011 T7155 T7154 punct ", ",mediating
R2012 T7156 T7157 advmod most,likely
R2013 T7157 T7154 advmod likely,mediating
R2014 T7253 T7251 nummod 6,C57BL
R2015 T7158 T7154 punct ", ",mediating
R2016 T7159 T7160 det the,region
R2017 T7255 T7254 aux has,reported
R2018 T7160 T7154 nsubj region,mediating
R2019 T7161 T7162 advmod 129,derived
R2020 T7162 T7160 amod derived,region
R2021 T7163 T7162 punct -,derived
R2022 T7256 T7254 advmod previously,reported
R2023 T7164 T7160 cc and,region
R2024 T7165 T7164 neg not,and
R2025 T7166 T7167 det the,lack
R2026 T7257 T7254 auxpass been,reported
R2027 T7167 T7160 conj lack,region
R2028 T7168 T7167 prep of,lack
R2029 T7258 T7259 aux to,be
R2030 T7169 T7168 pobj Apcs,of
R2031 T7170 T7154 aux was,mediating
R2032 T7171 T7172 det the,production
R2033 T7172 T7154 dobj production,mediating
R2034 T7173 T7172 prep of,production
R2035 T7174 T7173 pobj ANA,of
R2036 T7259 T7254 xcomp be,reported
R2037 T7175 T7174 cc and,ANA
R2038 T7260 T7259 attr one,be
R2039 T7176 T7177 amod anti-chromatin,Ab
R2040 T7177 T7174 conj Ab,ANA
R2041 T7178 T7152 punct .,demonstrates
R2042 T7261 T7260 prep of,one
R2043 T7180 T7181 advcl Consistent,found
R2044 T7262 T7263 det the,strains
R2045 T7182 T7180 prep with,Consistent
R2046 T7183 T7184 det this,explanation
R2047 T7263 T7261 pobj strains,of
R2048 T7184 T7182 pobj explanation,with
R2049 T7185 T7181 punct ", ",found
R2050 T7264 T7263 amod murine,strains
R2051 T7186 T7181 nsubj we,found
R2052 T7187 T7188 mark that,have
R2053 T7188 T7181 ccomp have,found
R2054 T7265 T7263 acl defined,strains
R2055 T7189 T7190 det the,mice
R2056 T7190 T7188 nsubj mice,have
R2057 T7191 T7190 nummod 129,mice
R2058 T7266 T7265 prep as,defined
R2059 T7192 T7193 advmod significantly,higher
R2060 T7193 T7194 amod higher,levels
R2061 T7267 T7268 amod low,producers
R2062 T7194 T7188 dobj levels,have
R2063 T7195 T7194 prep of,levels
R2064 T7196 T7195 pobj Apcs,of
R2065 T7268 T7266 pobj producers,as
R2066 T7197 T7194 prep in,levels
R2067 T7198 T7197 pobj circulation,in
R2068 T7269 T7268 compound Apcs,producers
R2069 T7199 T7188 prep compared,have
R2070 T7200 T7199 prep with,compared
R2071 T7201 T7202 det the,mice
R2072 T7270 T7271 punct (,Pepys
R2073 T7202 T7200 pobj mice,with
R2074 T7203 T7202 nmod C57BL,mice
R2075 T7204 T7203 punct /,C57BL
R2076 T7271 T7254 meta Pepys,reported
R2077 T7205 T7203 nummod 6,C57BL
R2078 T7206 T7207 punct (,0.0001
R2079 T7272 T7271 nmod et,Pepys
R2080 T7207 T7181 parataxis 0.0001,found
R2081 T7273 T7271 nmod al.,Pepys
R2082 T7208 T7209 dep median,mg
R2083 T7274 T7271 nummod 1979,Pepys
R2084 T7275 T7271 punct ;,Pepys
R2085 T7276 T7271 nmod Baltz,Pepys
R2086 T7277 T7271 nmod et,Pepys
R2087 T7278 T7271 nmod al.,Pepys
R2088 T7315 T7316 mark that,is
R2089 T7279 T7271 nummod 1980,Pepys
R2090 T7316 T7314 ccomp is,indicating
R2091 T7317 T7318 det a,variant
R2092 T7280 T7271 punct ),Pepys
R2093 T7318 T7316 nsubj variant,is
R2094 T7319 T7318 amod structural,variant
R2095 T7281 T7254 punct .,reported
R2096 T7320 T7318 prep of,variant
R2097 T7321 T7322 det the,protein
R2098 T7322 T7320 pobj protein,of
R2099 T7283 T7284 prep In,failed
R2100 T7323 T7316 acomp unlikely,is
R2101 T7324 T7325 aux to,be
R2102 T7325 T7323 xcomp be,unlikely
R2103 T7285 T7283 pobj addition,In
R2104 T7326 T7327 det the,explanation
R2105 T7327 T7325 attr explanation,be
R2106 T7328 T7327 prep for,explanation
R2107 T7329 T7330 poss our,findings
R2108 T7330 T7328 pobj findings,for
R2109 T7286 T7284 punct ", ",failed
R2110 T7331 T7284 punct .,failed
R2111 T7333 T7334 nsubj This,is
R2112 T7287 T7288 compound sequence,analysis
R2113 T7335 T7334 acomp consistent,is
R2114 T7336 T7335 prep with,consistent
R2115 T7288 T7284 nsubj analysis,failed
R2116 T7337 T7338 det a,report
R2117 T7338 T7336 pobj report,with
R2118 T7339 T7338 amod previous,report
R2119 T7289 T7288 prep of,analysis
R2120 T7340 T7338 prep by,report
R2121 T7341 T7340 pobj Drake,by
R2122 T7342 T7343 advmod et,al.
R2123 T7290 T7291 det the,region
R2124 T7343 T7341 advmod al.,Drake
R2125 T7344 T7341 punct (,Drake
R2126 T7345 T7341 npadvmod 1996,Drake
R2127 T7291 T7289 pobj region,of
R2128 T7346 T7341 punct ),Drake
R2129 T7347 T7348 dep that,showed
R2130 T7348 T7338 relcl showed,report
R2131 T7292 T7291 amod entire,region
R2132 T7349 T7350 det no,differences
R2133 T7350 T7348 dobj differences,showed
R2134 T7351 T7352 nmod Apcs,sequence
R2135 T7293 T7291 nmod Apcs,region
R2136 T7352 T7350 compound sequence,differences
R2137 T7353 T7352 amod coding,sequence
R2138 T7354 T7348 prep amongst,showed
R2139 T7355 T7356 amod several,strains
R2140 T7356 T7354 pobj strains,amongst
R2141 T7357 T7356 amod autoimmune,strains
R2142 T7294 T7291 amod coding,region
R2143 T7358 T7357 cc and,autoimmune
R2144 T7359 T7357 conj nonautoimmune,autoimmune
R2145 T7360 T7356 amod murine,strains
R2146 T7361 T7334 punct .,is
R2147 T7295 T7288 prep in,analysis
R2148 T7363 T7364 prep In,contributed
R2149 T7296 T7297 det both,strains
R2150 T7365 T7363 pobj addition,In
R2151 T7366 T7365 prep to,addition
R2152 T7297 T7295 pobj strains,in
R2153 T7367 T7368 det the,segments
R2154 T7368 T7366 pobj segments,to
R2155 T7369 T7370 advmod 129,derived
R2156 T7298 T7299 aux to,identify
R2157 T7370 T7368 amod derived,segments
R2158 T7371 T7370 punct -,derived
R2159 T7372 T7364 punct ", ",contributed
R2160 T7299 T7284 xcomp identify,failed
R2161 T7373 T7364 prep in,contributed
R2162 T7374 T7375 det both,cohorts
R2163 T7300 T7301 det any,polymorphisms
R2164 T7375 T7373 pobj cohorts,in
R2165 T7376 T7377 det the,strain
R2166 T7377 T7364 nsubj strain,contributed
R2167 T7301 T7299 dobj polymorphisms,identify
R2168 T7378 T7377 nmod C57BL,strain
R2169 T7379 T7378 punct /,C57BL
R2170 T7380 T7378 nummod 6,C57BL
R2171 T7302 T7303 amod coding,sequence
R2172 T7381 T7364 prep to,contributed
R2173 T7382 T7383 det the,traits
R2174 T7383 T7381 pobj traits,to
R2175 T7303 T7301 compound sequence,polymorphisms
R2176 T7384 T7383 amod autoimmune,traits
R2177 T7385 T7364 prep with,contributed
R2178 T7386 T7387 nummod one,locus
R2179 T7304 T7299 prep in,identify
R2180 T7387 T7385 pobj locus,with
R2181 T7388 T7387 amod major,locus
R2182 T7389 T7387 compound susceptibility,locus
R2183 T7305 T7306 det the,gene
R2184 T7390 T7387 prep on,locus
R2185 T7391 T7390 pobj Chromosome,on
R2186 T7392 T7391 nummod 3,Chromosome
R2187 T7306 T7304 pobj gene,in
R2188 T7393 T7364 punct .,contributed
R2189 T7395 T7396 det A,region
R2190 T7396 T7398 nsubj region,showed
R2191 T7307 T7306 compound Apcs,gene
R2192 T7397 T7396 amod genomic,region
R2193 T7399 T7396 prep between,region
R2194 T7308 T7309 punct (,shown
R2195 T7400 T7399 pobj D3Mit40,between
R2196 T7401 T7400 cc and,D3Mit40
R2197 T7402 T7400 conj D3Mit13,D3Mit40
R2198 T7309 T7299 parataxis shown,identify
R2199 T7403 T7396 punct ", ",region
R2200 T7404 T7396 prep with,region
R2201 T7310 T7309 nsubj data,shown
R2202 T7405 T7406 det an,peak
R2203 T7406 T7404 pobj peak,with
R2204 T7311 T7309 neg not,shown
R2205 T7407 T7406 amod estimated,peak
R2206 T7408 T7406 prep at,peak
R2207 T7312 T7309 punct ),shown
R2208 T7409 T7410 nmod position,cM
R2209 T7410 T7408 pobj cM,at
R2210 T7411 T7412 advmod approximately,51
R2211 T7313 T7299 punct ", ",identify
R2212 T7412 T7410 nummod 51,cM
R2213 T7413 T7398 punct ", ",showed
R2214 T7414 T7415 det a,linkage
R2215 T7314 T7299 advcl indicating,identify
R2216 T7415 T7398 dobj linkage,showed
R2217 T7416 T7415 amod significant,linkage
R2218 T7417 T7415 prep to,linkage
R2219 T7421 T7422 amod weaker,linkages
R2220 T7418 T7419 compound ANA,production
R2221 T7419 T7417 pobj production,to
R2222 T7420 T7415 cc and,linkage
R2223 T7422 T7415 conj linkages,linkage
R2224 T7423 T7422 prep to,linkages
R2225 T7424 T7425 amod anti-ssDNA,production
R2226 T7425 T7423 pobj production,to
R2227 T7526 T7522 prep on,effect
R2228 T7527 T7528 amod distal,Chromosome
R2229 T7426 T7424 cc and,anti-ssDNA
R2230 T7528 T7526 pobj Chromosome,on
R2231 T7529 T7528 nummod 1,Chromosome
R2232 T7427 T7424 conj anti-chromatin,anti-ssDNA
R2233 T7530 T7519 punct ", ",controlling
R2234 T7531 T7532 mark as,described
R2235 T7532 T7519 advcl described,controlling
R2236 T7428 T7429 punct (,see
R2237 T7533 T7532 advmod previously,described
R2238 T7534 T7535 punct (,Zeng
R2239 T7429 T7422 parataxis see,linkages
R2240 T7535 T7532 meta Zeng,described
R2241 T7536 T7535 nummod 1994,Zeng
R2242 T7537 T7535 punct ),Zeng
R2243 T7538 T7490 punct .,investigated
R2244 T7540 T7541 det The,results
R2245 T7541 T7542 nsubj results,showed
R2246 T7430 T7429 dobj Table,see
R2247 T7543 T7541 prep of,results
R2248 T7544 T7545 det this,analysis
R2249 T7431 T7430 nummod 3,Table
R2250 T7545 T7543 pobj analysis,of
R2251 T7546 T7547 mark that,increased
R2252 T7432 T7430 punct ;,Table
R2253 T7547 T7542 ccomp increased,showed
R2254 T7433 T7430 npadvmod Figure,Table
R2255 T7548 T7549 det the,support
R2256 T7549 T7547 nsubj support,increased
R2257 T7434 T7433 nummod 7,Figure
R2258 T7550 T7549 amod statistical,support
R2259 T7551 T7549 prep for,support
R2260 T7552 T7553 det the,linkage
R2261 T7435 T7429 punct ),see
R2262 T7553 T7551 pobj linkage,for
R2263 T7554 T7553 prep of,linkage
R2264 T7436 T7398 punct .,showed
R2265 T7555 T7556 det the,locus
R2266 T7556 T7554 pobj locus,of
R2267 T7557 T7556 nmod C57BL,locus
R2268 T7438 T7439 det The,frequency
R2269 T7558 T7557 punct /,C57BL
R2270 T7559 T7557 nummod 6,C57BL
R2271 T7560 T7553 prep on,linkage
R2272 T7561 T7560 pobj Chromosome,on
R2273 T7439 T7441 nsubj frequency,imply
R2274 T7562 T7561 nummod 3,Chromosome
R2275 T7563 T7553 prep for,linkage
R2276 T7564 T7563 pobj ANA,for
R2277 T7440 T7439 amod high,frequency
R2278 T7565 T7547 prep from,increased
R2279 T7566 T7565 pobj logarithm,from
R2280 T7567 T7566 prep of,logarithm
R2281 T7442 T7439 prep of,frequency
R2282 T7568 T7567 pobj odds,of
R2283 T7569 T7566 punct (,logarithm
R2284 T7570 T7566 appos LOD,logarithm
R2285 T7443 T7444 amod autoimmune,phenotype
R2286 T7571 T7566 punct ),logarithm
R2287 T7572 T7566 nummod 5.4,logarithm
R2288 T7444 T7442 pobj phenotype,of
R2289 T7573 T7565 prep to,from
R2290 T7574 T7573 pobj LOD,to
R2291 T7575 T7574 nummod 6.4,LOD
R2292 T7445 T7439 prep in,frequency
R2293 T7576 T7542 punct .,showed
R2294 T7578 T7579 prep In,identified
R2295 T7580 T7578 pobj contrast,In
R2296 T7581 T7580 prep to,contrast
R2297 T7446 T7447 det the,background
R2298 T7582 T7583 det these,associations
R2299 T7583 T7581 pobj associations,to
R2300 T7584 T7583 amod strong,associations
R2301 T7447 T7445 pobj background,in
R2302 T7585 T7583 prep with,associations
R2303 T7586 T7587 nmod disease,markers
R2304 T7587 T7585 pobj markers,with
R2305 T7448 T7447 punct (,background
R2306 T7588 T7587 amod serological,markers
R2307 T7589 T7579 punct ", ",identified
R2308 T7590 T7591 det the,analysis
R2309 T7449 T7447 nummod 129,background
R2310 T7591 T7579 nsubj analysis,identified
R2311 T7592 T7591 compound QTL,analysis
R2312 T7593 T7594 advmod only,linkages
R2313 T7450 T7449 punct ×,129
R2314 T7594 T7579 dobj linkages,identified
R2315 T7595 T7594 nummod two,linkages
R2316 T7451 T7449 appos C57BL,129
R2317 T7596 T7594 amod potential,linkages
R2318 T7597 T7594 prep to,linkages
R2319 T7452 T7451 punct /,C57BL
R2320 T7598 T7597 pobj glomerulonephritis,to
R2321 T7599 T7594 punct : ,linkages
R2322 T7600 T7594 appos one,linkages
R2323 T7453 T7451 nummod 6,C57BL
R2324 T7601 T7600 prep in,one
R2325 T7602 T7603 det the,mice
R2326 T7454 T7449 punct ),129
R2327 T7603 T7601 pobj mice,in
R2328 T7604 T7605 amod wild,type
R2329 T7455 T7449 amod hybrid,129
R2330 T7456 T7447 amod genetic,background
R2331 T7457 T7439 cc and,frequency
R2332 T7605 T7603 compound type,mice
R2333 T7458 T7459 poss its,absence
R2334 T7606 T7605 punct -,type
R2335 T7607 T7600 prep on,one
R2336 T7459 T7439 conj absence,frequency
R2337 T7608 T7607 pobj Chromosome,on
R2338 T7609 T7608 nummod 7,Chromosome
R2339 T7460 T7459 prep in,absence
R2340 T7610 T7600 prep across,one
R2341 T7611 T7612 det a,region
R2342 T7612 T7610 pobj region,across
R2343 T7461 T7460 pobj either,in
R2344 T7613 T7614 nummod 10,cM
R2345 T7614 T7612 compound cM,region
R2346 T7615 T7612 prep between,region
R2347 T7616 T7615 pobj D7Mit246,between
R2348 T7617 T7618 punct (,cM
R2349 T7618 T7616 parataxis cM,D7Mit246
R2350 T7462 T7461 prep of,either
R2351 T7619 T7618 nummod 15,cM
R2352 T7620 T7618 punct ),cM
R2353 T7621 T7616 cc and,D7Mit246
R2354 T7463 T7464 det the,strains
R2355 T7622 T7616 conj D7Mit145,D7Mit246
R2356 T7623 T7624 punct (,cM
R2357 T7624 T7622 parataxis cM,D7Mit145
R2358 T7464 T7462 pobj strains,of
R2359 T7625 T7624 nummod 26.5,cM
R2360 T7626 T7624 punct ),cM
R2361 T7627 T7600 prep of,one
R2362 T7465 T7464 amod inbred,strains
R2363 T7628 T7629 nummod 129,origin
R2364 T7629 T7627 pobj origin,of
R2365 T7466 T7464 amod parental,strains
R2366 T7630 T7631 punct (,LOD
R2367 T7631 T7629 parataxis LOD,origin
R2368 T7467 T7468 mark that,are
R2369 T7468 T7441 ccomp are,imply
R2370 T7469 T7468 expl there,are
R2371 T7632 T7631 nummod 2.86,LOD
R2372 T7633 T7631 punct ", ",LOD
R2373 T7470 T7471 amod essential,interactions
R2374 T7634 T7635 nsubj p,0.0013
R2375 T7471 T7468 attr interactions,are
R2376 T7635 T7631 ccomp 0.0013,LOD
R2377 T7636 T7635 punct =,0.0013
R2378 T7637 T7631 punct ),LOD
R2379 T7472 T7471 prep between,interactions
R2380 T7638 T7600 punct ", ",one
R2381 T7639 T7600 cc and,one
R2382 T7640 T7600 conj one,one
R2383 T7473 T7474 npadvmod 129,derived
R2384 T7641 T7640 prep on,one
R2385 T7642 T7641 pobj Chromosome,on
R2386 T7474 T7481 amod derived,alleles
R2387 T7643 T7642 nummod 17,Chromosome
R2388 T7644 T7640 prep between,one
R2389 T7645 T7644 pobj D17Mit100,between
R2390 T7475 T7473 punct -,129
R2391 T7646 T7647 punct (,cM
R2392 T7476 T7473 cc and,129
R2393 T7647 T7645 parataxis cM,D17Mit100
R2394 T7477 T7473 conj C57BL,129
R2395 T7648 T7647 nummod 11.7,cM
R2396 T7649 T7647 punct ),cM
R2397 T7650 T7645 cc and,D17Mit100
R2398 T7651 T7645 conj D17Mit216,D17Mit100
R2399 T7652 T7653 punct (,cM
R2400 T7478 T7477 punct /,C57BL
R2401 T7653 T7651 parataxis cM,D17Mit216
R2402 T7654 T7653 nummod 29.4,cM
R2403 T7655 T7653 punct ),cM
R2404 T7479 T7477 nummod 6,C57BL
R2405 T7656 T7640 prep from,one
R2406 T7480 T7477 punct -,C57BL
R2407 T7657 T7658 det the,strain
R2408 T7658 T7656 pobj strain,from
R2409 T7659 T7658 nmod C57BL,strain
R2410 T7481 T7472 pobj alleles,between
R2411 T7660 T7659 punct /,C57BL
R2412 T7661 T7659 nummod 6,C57BL
R2413 T7482 T7468 prep for,are
R2414 T7662 T7663 punct (,0.049
R2415 T7663 T7640 parataxis 0.049,one
R2416 T7664 T7663 dep LOD,0.049
R2417 T7483 T7484 det the,expression
R2418 T7665 T7664 nummod 1.3,LOD
R2419 T7666 T7663 punct ", ",0.049
R2420 T7484 T7482 pobj expression,for
R2421 T7667 T7663 nsubj p,0.049
R2422 T7668 T7663 punct =,0.049
R2423 T7669 T7663 cc and,0.049
R2424 T7485 T7484 prep of,expression
R2425 T7670 T7671 dep LOD,0.021
R2426 T7671 T7663 conj 0.021,0.049
R2427 T7672 T7670 nummod 1.67,LOD
R2428 T7486 T7485 pobj autoimmunity,of
R2429 T7673 T7671 punct ", ",0.021
R2430 T7487 T7441 punct .,imply
R2431 T7674 T7671 nsubj p,0.021
R2432 T7675 T7671 punct =,0.021
R2433 T7676 T7671 prep in,0.021
R2434 T7677 T7678 det the,mice
R2435 T7489 T7490 nsubj We,investigated
R2436 T7678 T7676 pobj mice,in
R2437 T7679 T7680 amod wild,type
R2438 T7680 T7678 nmod type,mice
R2439 T7681 T7680 punct -,type
R2440 T7491 T7490 advmod further,investigated
R2441 T7682 T7680 cc and,type
R2442 T7683 T7680 conj Apcs,type
R2443 T7684 T7683 punct −,Apcs
R2444 T7685 T7683 punct /,Apcs
R2445 T7492 T7493 det the,effects
R2446 T7686 T7683 punct −,Apcs
R2447 T7687 T7671 punct ", ",0.021
R2448 T7688 T7671 conj respectively,0.021
R2449 T7689 T7688 punct ),respectively
R2450 T7690 T7579 punct .,identified
R2451 T7493 T7490 dobj effects,investigated
R2452 T7692 T7693 amod Histological,evidence
R2453 T7693 T7694 nsubjpass evidence,found
R2454 T7494 T7493 prep of,effects
R2455 T7695 T7693 prep of,evidence
R2456 T7696 T7695 pobj glomerulonephritis,of
R2457 T7495 T7494 pobj genes,of
R2458 T7697 T7694 auxpass was,found
R2459 T7698 T7694 advmod only,found
R2460 T7699 T7694 prep in,found
R2461 T7496 T7495 prep from,genes
R2462 T7700 T7701 advmod approximately,20
R2463 T7701 T7702 nummod 20,%
R2464 T7702 T7699 pobj %,in
R2465 T7497 T7498 det the,background
R2466 T7703 T7702 prep of,%
R2467 T7704 T7705 det the,mice
R2468 T7498 T7496 pobj background,from
R2469 T7705 T7703 pobj mice,of
R2470 T7706 T7705 prep in,mice
R2471 T7707 T7708 det each,cohort
R2472 T7499 T7498 nmod C57BL,background
R2473 T7708 T7706 pobj cohort,in
R2474 T7709 T7694 punct ", ",found
R2475 T7710 T7711 dep which,reduces
R2476 T7500 T7499 punct /,C57BL
R2477 T7711 T7694 advcl reduces,found
R2478 T7712 T7713 det the,power
R2479 T7713 T7711 dobj power,reduces
R2480 T7501 T7499 nummod 6,C57BL
R2481 T7714 T7713 prep of,power
R2482 T7715 T7716 det the,analysis
R2483 T7502 T7490 prep by,investigated
R2484 T7716 T7714 pobj analysis,of
R2485 T7717 T7716 compound QTL,analysis
R2486 T7718 T7711 prep for,reduces
R2487 T7503 T7502 pcomp repeating,by
R2488 T7719 T7720 det this,trait
R2489 T7720 T7718 pobj trait,for
R2490 T7721 T7720 compound disease,trait
R2491 T7504 T7505 det the,analysis
R2492 T7722 T7694 punct .,found
R2493 T7505 T7503 dobj analysis,repeating
R2494 T7506 T7505 compound linkage,analysis
R2495 T7507 T7503 prep in,repeating
R2496 T7508 T7509 punct (,mice
R2497 T7509 T7507 pobj mice,in
R2498 T7510 T7509 nummod 129,mice
R2499 T7511 T7510 punct ×,129
R2500 T7512 T7510 appos C57BL,129
R2501 T7513 T7512 punct /,C57BL
R2502 T7514 T7512 nummod 6,C57BL
R2503 T7515 T7509 punct ),mice
R2504 T7516 T7509 compound F2,mice
R2505 T7517 T7503 punct ", ",repeating
R2506 T7518 T7519 mark whilst,controlling
R2507 T7519 T7503 advcl controlling,repeating
R2508 T7520 T7519 prep for,controlling
R2509 T7521 T7522 det the,effect
R2510 T7522 T7520 pobj effect,for
R2511 T7523 T7524 advmod very,strong
R2512 T7524 T7522 amod strong,effect
R2513 T7525 T7522 nummod 129,effect