Id |
Subject |
Object |
Predicate |
Lexical cue |
T13555 |
0-5 |
EX |
denotes |
There |
T13556 |
6-8 |
VBZ |
denotes |
is |
T13557 |
9-21 |
VBG |
denotes |
accumulating |
T13558 |
22-30 |
NN |
denotes |
evidence |
T13559 |
31-35 |
IN |
denotes |
that |
T13561 |
36-46 |
NN |
denotes |
background |
T13562 |
47-52 |
NNS |
denotes |
genes |
T13563 |
53-56 |
MD |
denotes |
may |
T13560 |
57-66 |
VB |
denotes |
influence |
T13564 |
67-70 |
DT |
denotes |
the |
T13565 |
71-81 |
NN |
denotes |
expression |
T13566 |
82-84 |
IN |
denotes |
of |
T13567 |
85-97 |
NN |
denotes |
autoimmunity |
T13568 |
98-100 |
IN |
denotes |
in |
T13569 |
101-105 |
NN |
denotes |
gene |
T13571 |
105-106 |
HYPH |
denotes |
- |
T13570 |
106-114 |
VBN |
denotes |
targeted |
T13572 |
115-119 |
NNS |
denotes |
mice |
T13573 |
119-120 |
. |
denotes |
. |
T13574 |
120-280 |
sentence |
denotes |
Here we report what is to our knowledge the first systematic study that has examined this in the 129 and C57BL/6 mouse strains, widely used for gene targeting. |
T13575 |
121-125 |
RB |
denotes |
Here |
T13577 |
126-128 |
PRP |
denotes |
we |
T13576 |
129-135 |
VBP |
denotes |
report |
T13578 |
136-140 |
WP |
denotes |
what |
T13579 |
141-143 |
VBZ |
denotes |
is |
T13580 |
144-146 |
IN |
denotes |
to |
T13581 |
147-150 |
PRP$ |
denotes |
our |
T13582 |
151-160 |
NN |
denotes |
knowledge |
T13583 |
161-164 |
DT |
denotes |
the |
T13585 |
165-170 |
JJ |
denotes |
first |
T13586 |
171-181 |
JJ |
denotes |
systematic |
T13584 |
182-187 |
NN |
denotes |
study |
T13587 |
188-192 |
WDT |
denotes |
that |
T13589 |
193-196 |
VBZ |
denotes |
has |
T13588 |
197-205 |
VBN |
denotes |
examined |
T13590 |
206-210 |
DT |
denotes |
this |
T13591 |
211-213 |
IN |
denotes |
in |
T13592 |
214-217 |
DT |
denotes |
the |
T13594 |
218-221 |
CD |
denotes |
129 |
T13595 |
222-225 |
CC |
denotes |
and |
T13596 |
226-231 |
NN |
denotes |
C57BL |
T13597 |
231-232 |
HYPH |
denotes |
/ |
T13598 |
232-233 |
CD |
denotes |
6 |
T13599 |
234-239 |
NN |
denotes |
mouse |
T13593 |
240-247 |
NNS |
denotes |
strains |
T13600 |
247-249 |
, |
denotes |
, |
T13601 |
249-255 |
RB |
denotes |
widely |
T13602 |
256-260 |
VBN |
denotes |
used |
T13603 |
261-264 |
IN |
denotes |
for |
T13604 |
265-269 |
NN |
denotes |
gene |
T13605 |
270-279 |
NN |
denotes |
targeting |
T13606 |
279-280 |
. |
denotes |
. |
T13607 |
280-480 |
sentence |
denotes |
Our results demonstrate interacting loci between 129 and C57BL/6 mice that can cause the expression of a powerful autoimmune phenotype in these animals, in the absence of any gene-targeted mutations. |
T13608 |
281-284 |
PRP$ |
denotes |
Our |
T13609 |
285-292 |
NNS |
denotes |
results |
T13610 |
293-304 |
VBP |
denotes |
demonstrate |
T13611 |
305-316 |
VBG |
denotes |
interacting |
T13612 |
317-321 |
NNS |
denotes |
loci |
T13613 |
322-329 |
IN |
denotes |
between |
T13614 |
330-333 |
CD |
denotes |
129 |
T13616 |
334-337 |
CC |
denotes |
and |
T13617 |
338-343 |
NN |
denotes |
C57BL |
T13618 |
343-344 |
HYPH |
denotes |
/ |
T13619 |
344-345 |
CD |
denotes |
6 |
T13615 |
346-350 |
NNS |
denotes |
mice |
T13620 |
351-355 |
WDT |
denotes |
that |
T13622 |
356-359 |
MD |
denotes |
can |
T13621 |
360-365 |
VB |
denotes |
cause |
T13623 |
366-369 |
DT |
denotes |
the |
T13624 |
370-380 |
NN |
denotes |
expression |
T13625 |
381-383 |
IN |
denotes |
of |
T13626 |
384-385 |
DT |
denotes |
a |
T13628 |
386-394 |
JJ |
denotes |
powerful |
T13629 |
395-405 |
JJ |
denotes |
autoimmune |
T13627 |
406-415 |
NN |
denotes |
phenotype |
T13630 |
416-418 |
IN |
denotes |
in |
T13631 |
419-424 |
DT |
denotes |
these |
T13632 |
425-432 |
NNS |
denotes |
animals |
T13633 |
432-434 |
, |
denotes |
, |
T13634 |
434-436 |
IN |
denotes |
in |
T13635 |
437-440 |
DT |
denotes |
the |
T13636 |
441-448 |
NN |
denotes |
absence |
T13637 |
449-451 |
IN |
denotes |
of |
T13638 |
452-455 |
DT |
denotes |
any |
T13640 |
456-460 |
NN |
denotes |
gene |
T13642 |
460-461 |
HYPH |
denotes |
- |
T13641 |
461-469 |
VBN |
denotes |
targeted |
T13639 |
470-479 |
NNS |
denotes |
mutations |
T13643 |
479-480 |
. |
denotes |
. |
T13644 |
480-675 |
sentence |
denotes |
We also developed a congenic mouse strain bearing a portion of 129 Chromosome 1 on a C57BL/6 background and showed that this wild-type congenic line expressed striking anti-nuclear autoimmunity. |
T13645 |
481-483 |
PRP |
denotes |
We |
T13647 |
484-488 |
RB |
denotes |
also |
T13646 |
489-498 |
VBD |
denotes |
developed |
T13648 |
499-500 |
DT |
denotes |
a |
T13650 |
501-509 |
JJ |
denotes |
congenic |
T13651 |
510-515 |
NN |
denotes |
mouse |
T13649 |
516-522 |
NN |
denotes |
strain |
T13652 |
523-530 |
VBG |
denotes |
bearing |
T13653 |
531-532 |
DT |
denotes |
a |
T13654 |
533-540 |
NN |
denotes |
portion |
T13655 |
541-543 |
IN |
denotes |
of |
T13656 |
544-547 |
CD |
denotes |
129 |
T13657 |
548-558 |
NN |
denotes |
Chromosome |
T13658 |
559-560 |
CD |
denotes |
1 |
T13659 |
561-563 |
IN |
denotes |
on |
T13660 |
564-565 |
DT |
denotes |
a |
T13662 |
566-571 |
NN |
denotes |
C57BL |
T13663 |
571-572 |
HYPH |
denotes |
/ |
T13664 |
572-573 |
CD |
denotes |
6 |
T13661 |
574-584 |
NN |
denotes |
background |
T13665 |
585-588 |
CC |
denotes |
and |
T13666 |
589-595 |
VBD |
denotes |
showed |
T13667 |
596-600 |
IN |
denotes |
that |
T13669 |
601-605 |
DT |
denotes |
this |
T13671 |
606-610 |
JJ |
denotes |
wild |
T13673 |
610-611 |
HYPH |
denotes |
- |
T13672 |
611-615 |
NN |
denotes |
type |
T13674 |
616-624 |
JJ |
denotes |
congenic |
T13670 |
625-629 |
NN |
denotes |
line |
T13668 |
630-639 |
VBD |
denotes |
expressed |
T13675 |
640-648 |
JJ |
denotes |
striking |
T13677 |
649-661 |
JJ |
denotes |
anti-nuclear |
T13676 |
662-674 |
NN |
denotes |
autoimmunity |
T13678 |
674-675 |
. |
denotes |
. |
T13679 |
675-1034 |
sentence |
denotes |
By comparing this Chromosome 1 congenic strain with matched congenic mice lacking the Apcs gene, we demonstrated that serum amyloid P component deficiency influences the severity of glomerulonephritis, but is not the prime mover in the induction of anti-nuclear autoimmunity, contrary to our own original interpretation of our data (Bickerstaff et al. 1999). |
T13680 |
676-678 |
IN |
denotes |
By |
T13682 |
679-688 |
VBG |
denotes |
comparing |
T13683 |
689-693 |
DT |
denotes |
this |
T13685 |
694-704 |
NN |
denotes |
Chromosome |
T13686 |
705-706 |
CD |
denotes |
1 |
T13687 |
707-715 |
JJ |
denotes |
congenic |
T13684 |
716-722 |
NN |
denotes |
strain |
T13688 |
723-727 |
IN |
denotes |
with |
T13689 |
728-735 |
VBN |
denotes |
matched |
T13691 |
736-744 |
JJ |
denotes |
congenic |
T13690 |
745-749 |
NNS |
denotes |
mice |
T13692 |
750-757 |
VBG |
denotes |
lacking |
T13693 |
758-761 |
DT |
denotes |
the |
T13695 |
762-766 |
NN |
denotes |
Apcs |
T13694 |
767-771 |
NN |
denotes |
gene |
T13696 |
771-773 |
, |
denotes |
, |
T13697 |
773-775 |
PRP |
denotes |
we |
T13681 |
776-788 |
VBD |
denotes |
demonstrated |
T13698 |
789-793 |
IN |
denotes |
that |
T13700 |
794-799 |
NN |
denotes |
serum |
T13702 |
800-807 |
NN |
denotes |
amyloid |
T13703 |
808-809 |
NN |
denotes |
P |
T13701 |
810-819 |
NN |
denotes |
component |
T13704 |
820-830 |
NN |
denotes |
deficiency |
T13699 |
831-841 |
VBZ |
denotes |
influences |
T13705 |
842-845 |
DT |
denotes |
the |
T13706 |
846-854 |
NN |
denotes |
severity |
T13707 |
855-857 |
IN |
denotes |
of |
T13708 |
858-876 |
NN |
denotes |
glomerulonephritis |
T13709 |
876-878 |
, |
denotes |
, |
T13710 |
878-881 |
CC |
denotes |
but |
T13711 |
882-884 |
VBZ |
denotes |
is |
T13712 |
885-888 |
RB |
denotes |
not |
T13713 |
889-892 |
DT |
denotes |
the |
T13715 |
893-898 |
JJ |
denotes |
prime |
T13714 |
899-904 |
NN |
denotes |
mover |
T13716 |
905-907 |
IN |
denotes |
in |
T13717 |
908-911 |
DT |
denotes |
the |
T13718 |
912-921 |
NN |
denotes |
induction |
T13719 |
922-924 |
IN |
denotes |
of |
T13720 |
925-937 |
JJ |
denotes |
anti-nuclear |
T13721 |
938-950 |
NN |
denotes |
autoimmunity |
T13722 |
950-952 |
, |
denotes |
, |
T13723 |
952-960 |
JJ |
denotes |
contrary |
T13724 |
961-963 |
IN |
denotes |
to |
T13725 |
964-967 |
PRP$ |
denotes |
our |
T13727 |
968-971 |
JJ |
denotes |
own |
T13728 |
972-980 |
JJ |
denotes |
original |
T13726 |
981-995 |
NN |
denotes |
interpretation |
T13729 |
996-998 |
IN |
denotes |
of |
T13730 |
999-1002 |
PRP$ |
denotes |
our |
T13731 |
1003-1007 |
NNS |
denotes |
data |
T13732 |
1008-1009 |
-LRB- |
denotes |
( |
T13733 |
1009-1020 |
NNP |
denotes |
Bickerstaff |
T13734 |
1021-1023 |
FW |
denotes |
et |
T13735 |
1024-1027 |
FW |
denotes |
al. |
T13736 |
1028-1032 |
CD |
denotes |
1999 |
T13737 |
1032-1033 |
-RRB- |
denotes |
) |
T13738 |
1033-1034 |
. |
denotes |
. |
T13739 |
1034-1349 |
sentence |
denotes |
The same consideration applies to other genes located in the same Chromosome 1 region that have been implicated in the development of SLE when inactivated by gene-targeting in 129 embryonic stem cells and then backcrossed onto a pure genetic background (Bolland and Ravetch 2000; Miwa et al. 2002; Wu et al. 2002). |
T13740 |
1035-1038 |
DT |
denotes |
The |
T13742 |
1039-1043 |
JJ |
denotes |
same |
T13741 |
1044-1057 |
NN |
denotes |
consideration |
T13743 |
1058-1065 |
VBZ |
denotes |
applies |
T13744 |
1066-1068 |
IN |
denotes |
to |
T13745 |
1069-1074 |
JJ |
denotes |
other |
T13746 |
1075-1080 |
NNS |
denotes |
genes |
T13747 |
1081-1088 |
VBN |
denotes |
located |
T13748 |
1089-1091 |
IN |
denotes |
in |
T13749 |
1092-1095 |
DT |
denotes |
the |
T13751 |
1096-1100 |
JJ |
denotes |
same |
T13752 |
1101-1111 |
NN |
denotes |
Chromosome |
T13753 |
1112-1113 |
CD |
denotes |
1 |
T13750 |
1114-1120 |
NN |
denotes |
region |
T13754 |
1121-1125 |
WDT |
denotes |
that |
T13756 |
1126-1130 |
VBP |
denotes |
have |
T13757 |
1131-1135 |
VBN |
denotes |
been |
T13755 |
1136-1146 |
VBN |
denotes |
implicated |
T13758 |
1147-1149 |
IN |
denotes |
in |
T13759 |
1150-1153 |
DT |
denotes |
the |
T13760 |
1154-1165 |
NN |
denotes |
development |
T13761 |
1166-1168 |
IN |
denotes |
of |
T13762 |
1169-1172 |
NN |
denotes |
SLE |
T13763 |
1173-1177 |
WRB |
denotes |
when |
T13764 |
1178-1189 |
VBN |
denotes |
inactivated |
T13765 |
1190-1192 |
IN |
denotes |
by |
T13766 |
1193-1197 |
NN |
denotes |
gene |
T13767 |
1197-1198 |
HYPH |
denotes |
- |
T13768 |
1198-1207 |
VBG |
denotes |
targeting |
T13769 |
1208-1210 |
IN |
denotes |
in |
T13770 |
1211-1214 |
CD |
denotes |
129 |
T13772 |
1215-1224 |
JJ |
denotes |
embryonic |
T13773 |
1225-1229 |
NN |
denotes |
stem |
T13771 |
1230-1235 |
NNS |
denotes |
cells |
T13774 |
1236-1239 |
CC |
denotes |
and |
T13775 |
1240-1244 |
RB |
denotes |
then |
T13776 |
1245-1256 |
VBD |
denotes |
backcrossed |
T13777 |
1257-1261 |
IN |
denotes |
onto |
T13778 |
1262-1263 |
DT |
denotes |
a |
T13780 |
1264-1268 |
JJ |
denotes |
pure |
T13781 |
1269-1276 |
JJ |
denotes |
genetic |
T13779 |
1277-1287 |
NN |
denotes |
background |
T13782 |
1288-1289 |
-LRB- |
denotes |
( |
T13783 |
1289-1296 |
NNP |
denotes |
Bolland |
T13784 |
1297-1300 |
CC |
denotes |
and |
T13785 |
1301-1308 |
NNP |
denotes |
Ravetch |
T13786 |
1309-1313 |
CD |
denotes |
2000 |
T13787 |
1313-1314 |
: |
denotes |
; |
T13788 |
1315-1319 |
NNP |
denotes |
Miwa |
T13789 |
1320-1322 |
FW |
denotes |
et |
T13790 |
1323-1326 |
FW |
denotes |
al. |
T13791 |
1327-1331 |
CD |
denotes |
2002 |
T13792 |
1331-1332 |
: |
denotes |
; |
T13793 |
1333-1335 |
NNP |
denotes |
Wu |
T13794 |
1336-1338 |
FW |
denotes |
et |
T13795 |
1339-1342 |
FW |
denotes |
al. |
T13796 |
1343-1347 |
CD |
denotes |
2002 |
T13797 |
1347-1348 |
-RRB- |
denotes |
) |
T13798 |
1348-1349 |
. |
denotes |
. |
T13799 |
1349-1548 |
sentence |
denotes |
For each, there has to be a question as to whether the anti-nuclear autoimmunity is due to the gene-targeted mutant gene or to the normal 129 genes expressed in the same region as the targeted gene. |
T13800 |
1350-1353 |
IN |
denotes |
For |
T13802 |
1354-1358 |
DT |
denotes |
each |
T13803 |
1358-1360 |
, |
denotes |
, |
T13804 |
1360-1365 |
EX |
denotes |
there |
T13801 |
1366-1369 |
VBZ |
denotes |
has |
T13805 |
1370-1372 |
TO |
denotes |
to |
T13806 |
1373-1375 |
VB |
denotes |
be |
T13807 |
1376-1377 |
DT |
denotes |
a |
T13808 |
1378-1386 |
NN |
denotes |
question |
T13809 |
1387-1389 |
IN |
denotes |
as |
T13810 |
1390-1392 |
IN |
denotes |
to |
T13811 |
1393-1400 |
IN |
denotes |
whether |
T13813 |
1401-1404 |
DT |
denotes |
the |
T13815 |
1405-1417 |
JJ |
denotes |
anti-nuclear |
T13814 |
1418-1430 |
NN |
denotes |
autoimmunity |
T13812 |
1431-1433 |
VBZ |
denotes |
is |
T13816 |
1434-1437 |
IN |
denotes |
due |
T13817 |
1438-1440 |
IN |
denotes |
to |
T13818 |
1441-1444 |
DT |
denotes |
the |
T13820 |
1445-1449 |
NN |
denotes |
gene |
T13822 |
1449-1450 |
HYPH |
denotes |
- |
T13821 |
1450-1458 |
VBN |
denotes |
targeted |
T13823 |
1459-1465 |
NN |
denotes |
mutant |
T13819 |
1466-1470 |
NN |
denotes |
gene |
T13824 |
1471-1473 |
CC |
denotes |
or |
T13825 |
1474-1476 |
IN |
denotes |
to |
T13826 |
1477-1480 |
DT |
denotes |
the |
T13828 |
1481-1487 |
JJ |
denotes |
normal |
T13829 |
1488-1491 |
CD |
denotes |
129 |
T13827 |
1492-1497 |
NNS |
denotes |
genes |
T13830 |
1498-1507 |
VBN |
denotes |
expressed |
T13831 |
1508-1510 |
IN |
denotes |
in |
T13832 |
1511-1514 |
DT |
denotes |
the |
T13834 |
1515-1519 |
JJ |
denotes |
same |
T13833 |
1520-1526 |
NN |
denotes |
region |
T13835 |
1527-1529 |
IN |
denotes |
as |
T13836 |
1530-1533 |
DT |
denotes |
the |
T13838 |
1534-1542 |
VBN |
denotes |
targeted |
T13837 |
1543-1547 |
NN |
denotes |
gene |
T13839 |
1547-1548 |
. |
denotes |
. |
R3040 |
T13555 |
T13556 |
expl |
There,is |
R3042 |
T13557 |
T13558 |
amod |
accumulating,evidence |
R3044 |
T13558 |
T13556 |
attr |
evidence,is |
R3045 |
T13559 |
T13560 |
mark |
that,influence |
R3046 |
T13560 |
T13558 |
acl |
influence,evidence |
R3048 |
T13561 |
T13562 |
compound |
background,genes |
R3049 |
T13562 |
T13560 |
nsubj |
genes,influence |
R3050 |
T13563 |
T13560 |
aux |
may,influence |
R3051 |
T13564 |
T13565 |
det |
the,expression |
R3052 |
T13565 |
T13560 |
dobj |
expression,influence |
R3053 |
T13566 |
T13565 |
prep |
of,expression |
R3054 |
T13567 |
T13566 |
pobj |
autoimmunity,of |
R3055 |
T13568 |
T13560 |
prep |
in,influence |
R3056 |
T13569 |
T13570 |
npadvmod |
gene,targeted |
R3057 |
T13570 |
T13572 |
amod |
targeted,mice |
R3058 |
T13571 |
T13570 |
punct |
-,targeted |
R3059 |
T13572 |
T13568 |
pobj |
mice,in |
R3060 |
T13573 |
T13556 |
punct |
.,is |
R3061 |
T13575 |
T13576 |
advmod |
Here,report |
R3062 |
T13577 |
T13576 |
nsubj |
we,report |
R3063 |
T13578 |
T13579 |
dep |
what,is |
R3064 |
T13579 |
T13576 |
ccomp |
is,report |
R3066 |
T13580 |
T13579 |
prep |
to,is |
R3067 |
T13581 |
T13582 |
poss |
our,knowledge |
R3068 |
T13582 |
T13580 |
pobj |
knowledge,to |
R3069 |
T13583 |
T13584 |
det |
the,study |
R3070 |
T13584 |
T13579 |
attr |
study,is |
R3071 |
T13585 |
T13584 |
amod |
first,study |
R3072 |
T13586 |
T13584 |
amod |
systematic,study |
R3073 |
T13587 |
T13588 |
dep |
that,examined |
R3074 |
T13588 |
T13584 |
relcl |
examined,study |
R3075 |
T13589 |
T13588 |
aux |
has,examined |
R3076 |
T13590 |
T13588 |
dobj |
this,examined |
R3077 |
T13591 |
T13588 |
prep |
in,examined |
R3078 |
T13592 |
T13593 |
det |
the,strains |
R3079 |
T13593 |
T13591 |
pobj |
strains,in |
R3080 |
T13594 |
T13593 |
nummod |
129,strains |
R3081 |
T13595 |
T13594 |
cc |
and,129 |
R3082 |
T13596 |
T13594 |
conj |
C57BL,129 |
R3083 |
T13600 |
T13593 |
punct |
", ",strains |
R3084 |
T13597 |
T13596 |
punct |
/,C57BL |
R3085 |
T13601 |
T13602 |
advmod |
widely,used |
R3086 |
T13602 |
T13593 |
acl |
used,strains |
R3087 |
T13598 |
T13596 |
nummod |
6,C57BL |
R3088 |
T13603 |
T13602 |
prep |
for,used |
R3089 |
T13604 |
T13605 |
compound |
gene,targeting |
R3090 |
T13605 |
T13603 |
pobj |
targeting,for |
R3091 |
T13599 |
T13593 |
compound |
mouse,strains |
R3092 |
T13606 |
T13576 |
punct |
.,report |
R3093 |
T13608 |
T13609 |
poss |
Our,results |
R3094 |
T13706 |
T13699 |
dobj |
severity,influences |
R3095 |
T13609 |
T13610 |
nsubj |
results,demonstrate |
R3096 |
T13611 |
T13612 |
amod |
interacting,loci |
R3097 |
T13707 |
T13706 |
prep |
of,severity |
R3098 |
T13612 |
T13610 |
dobj |
loci,demonstrate |
R3099 |
T13613 |
T13612 |
prep |
between,loci |
R3100 |
T13614 |
T13615 |
nummod |
129,mice |
R3101 |
T13708 |
T13707 |
pobj |
glomerulonephritis,of |
R3102 |
T13615 |
T13613 |
pobj |
mice,between |
R3103 |
T13616 |
T13614 |
cc |
and,129 |
R3104 |
T13709 |
T13699 |
punct |
", ",influences |
R3105 |
T13617 |
T13614 |
conj |
C57BL,129 |
R3106 |
T13618 |
T13617 |
punct |
/,C57BL |
R3107 |
T13619 |
T13617 |
nummod |
6,C57BL |
R3108 |
T13710 |
T13699 |
cc |
but,influences |
R3109 |
T13620 |
T13621 |
dep |
that,cause |
R3110 |
T13621 |
T13612 |
relcl |
cause,loci |
R3111 |
T13622 |
T13621 |
aux |
can,cause |
R3112 |
T13711 |
T13699 |
conj |
is,influences |
R3113 |
T13623 |
T13624 |
det |
the,expression |
R3114 |
T13624 |
T13621 |
dobj |
expression,cause |
R3115 |
T13625 |
T13624 |
prep |
of,expression |
R3116 |
T13712 |
T13711 |
neg |
not,is |
R3117 |
T13626 |
T13627 |
det |
a,phenotype |
R3118 |
T13627 |
T13625 |
pobj |
phenotype,of |
R3119 |
T13713 |
T13714 |
det |
the,mover |
R3120 |
T13628 |
T13627 |
amod |
powerful,phenotype |
R3121 |
T13629 |
T13627 |
amod |
autoimmune,phenotype |
R3122 |
T13630 |
T13621 |
prep |
in,cause |
R3123 |
T13714 |
T13711 |
attr |
mover,is |
R3124 |
T13631 |
T13632 |
det |
these,animals |
R3125 |
T13632 |
T13630 |
pobj |
animals,in |
R3126 |
T13633 |
T13621 |
punct |
", ",cause |
R3127 |
T13715 |
T13714 |
amod |
prime,mover |
R3128 |
T13634 |
T13621 |
prep |
in,cause |
R3129 |
T13716 |
T13711 |
prep |
in,is |
R3130 |
T13717 |
T13718 |
det |
the,induction |
R3131 |
T13635 |
T13636 |
det |
the,absence |
R3132 |
T13636 |
T13634 |
pobj |
absence,in |
R3133 |
T13718 |
T13716 |
pobj |
induction,in |
R3134 |
T13637 |
T13636 |
prep |
of,absence |
R3135 |
T13638 |
T13639 |
det |
any,mutations |
R3136 |
T13639 |
T13637 |
pobj |
mutations,of |
R3137 |
T13640 |
T13641 |
npadvmod |
gene,targeted |
R3138 |
T13641 |
T13639 |
amod |
targeted,mutations |
R3139 |
T13642 |
T13641 |
punct |
-,targeted |
R3140 |
T13719 |
T13718 |
prep |
of,induction |
R3141 |
T13643 |
T13610 |
punct |
.,demonstrate |
R3142 |
T13720 |
T13721 |
amod |
anti-nuclear,autoimmunity |
R3143 |
T13645 |
T13646 |
nsubj |
We,developed |
R3144 |
T13647 |
T13646 |
advmod |
also,developed |
R3145 |
T13721 |
T13719 |
pobj |
autoimmunity,of |
R3146 |
T13648 |
T13649 |
det |
a,strain |
R3147 |
T13649 |
T13646 |
dobj |
strain,developed |
R3148 |
T13722 |
T13711 |
punct |
", ",is |
R3149 |
T13650 |
T13649 |
amod |
congenic,strain |
R3150 |
T13651 |
T13649 |
compound |
mouse,strain |
R3151 |
T13652 |
T13649 |
acl |
bearing,strain |
R3152 |
T13723 |
T13711 |
advcl |
contrary,is |
R3153 |
T13653 |
T13654 |
det |
a,portion |
R3154 |
T13654 |
T13652 |
dobj |
portion,bearing |
R3155 |
T13655 |
T13654 |
prep |
of,portion |
R3156 |
T13724 |
T13723 |
prep |
to,contrary |
R3157 |
T13656 |
T13657 |
nummod |
129,Chromosome |
R3158 |
T13657 |
T13655 |
pobj |
Chromosome,of |
R3159 |
T13725 |
T13726 |
poss |
our,interpretation |
R3160 |
T13658 |
T13657 |
nummod |
1,Chromosome |
R3161 |
T13659 |
T13652 |
prep |
on,bearing |
R3162 |
T13660 |
T13661 |
det |
a,background |
R3163 |
T13726 |
T13724 |
pobj |
interpretation,to |
R3164 |
T13661 |
T13659 |
pobj |
background,on |
R3165 |
T13662 |
T13661 |
nmod |
C57BL,background |
R3166 |
T13663 |
T13662 |
punct |
/,C57BL |
R3167 |
T13727 |
T13726 |
amod |
own,interpretation |
R3168 |
T13664 |
T13662 |
nummod |
6,C57BL |
R3169 |
T13728 |
T13726 |
amod |
original,interpretation |
R3170 |
T13665 |
T13646 |
cc |
and,developed |
R3171 |
T13666 |
T13646 |
conj |
showed,developed |
R3172 |
T13667 |
T13668 |
mark |
that,expressed |
R3173 |
T13668 |
T13666 |
ccomp |
expressed,showed |
R3174 |
T13729 |
T13726 |
prep |
of,interpretation |
R3175 |
T13669 |
T13670 |
det |
this,line |
R3176 |
T13670 |
T13668 |
nsubj |
line,expressed |
R3177 |
T13671 |
T13672 |
amod |
wild,type |
R3178 |
T13672 |
T13670 |
nmod |
type,line |
R3179 |
T13730 |
T13731 |
poss |
our,data |
R3180 |
T13673 |
T13672 |
punct |
-,type |
R3181 |
T13674 |
T13670 |
amod |
congenic,line |
R3182 |
T13675 |
T13676 |
amod |
striking,autoimmunity |
R3183 |
T13731 |
T13729 |
pobj |
data,of |
R3184 |
T13676 |
T13668 |
dobj |
autoimmunity,expressed |
R3185 |
T13677 |
T13676 |
amod |
anti-nuclear,autoimmunity |
R3186 |
T13678 |
T13646 |
punct |
.,developed |
R3187 |
T13680 |
T13681 |
prep |
By,demonstrated |
R3188 |
T13732 |
T13733 |
punct |
(,Bickerstaff |
R3189 |
T13682 |
T13680 |
pcomp |
comparing,By |
R3190 |
T13683 |
T13684 |
det |
this,strain |
R3191 |
T13684 |
T13682 |
dobj |
strain,comparing |
R3192 |
T13733 |
T13711 |
meta |
Bickerstaff,is |
R3193 |
T13685 |
T13684 |
nmod |
Chromosome,strain |
R3194 |
T13686 |
T13685 |
nummod |
1,Chromosome |
R3195 |
T13687 |
T13684 |
amod |
congenic,strain |
R3196 |
T13734 |
T13733 |
nmod |
et,Bickerstaff |
R3197 |
T13688 |
T13682 |
prep |
with,comparing |
R3198 |
T13689 |
T13690 |
amod |
matched,mice |
R3199 |
T13690 |
T13688 |
pobj |
mice,with |
R3200 |
T13735 |
T13733 |
nmod |
al.,Bickerstaff |
R3201 |
T13691 |
T13690 |
amod |
congenic,mice |
R3202 |
T13692 |
T13690 |
acl |
lacking,mice |
R3203 |
T13693 |
T13694 |
det |
the,gene |
R3204 |
T13736 |
T13733 |
nummod |
1999,Bickerstaff |
R3205 |
T13694 |
T13692 |
dobj |
gene,lacking |
R3206 |
T13695 |
T13694 |
compound |
Apcs,gene |
R3207 |
T13696 |
T13681 |
punct |
", ",demonstrated |
R3208 |
T13737 |
T13733 |
punct |
),Bickerstaff |
R3209 |
T13697 |
T13681 |
nsubj |
we,demonstrated |
R3210 |
T13698 |
T13699 |
mark |
that,influences |
R3211 |
T13738 |
T13681 |
punct |
.,demonstrated |
R3212 |
T13699 |
T13681 |
ccomp |
influences,demonstrated |
R3213 |
T13700 |
T13701 |
compound |
serum,component |
R3214 |
T13701 |
T13704 |
compound |
component,deficiency |
R3215 |
T13740 |
T13741 |
det |
The,consideration |
R3216 |
T13702 |
T13701 |
compound |
amyloid,component |
R3217 |
T13703 |
T13701 |
compound |
P,component |
R3218 |
T13704 |
T13699 |
nsubj |
deficiency,influences |
R3219 |
T13705 |
T13706 |
det |
the,severity |
R3220 |
T13741 |
T13743 |
nsubj |
consideration,applies |
R3221 |
T13742 |
T13741 |
amod |
same,consideration |
R3222 |
T13744 |
T13743 |
prep |
to,applies |
R3223 |
T13745 |
T13746 |
amod |
other,genes |
R3224 |
T13812 |
T13810 |
pcomp |
is,to |
R3225 |
T13813 |
T13814 |
det |
the,autoimmunity |
R3226 |
T13746 |
T13744 |
pobj |
genes,to |
R3227 |
T13814 |
T13812 |
nsubj |
autoimmunity,is |
R3228 |
T13815 |
T13814 |
amod |
anti-nuclear,autoimmunity |
R3229 |
T13816 |
T13812 |
prep |
due,is |
R3230 |
T13747 |
T13746 |
acl |
located,genes |
R3231 |
T13817 |
T13816 |
prep |
to,due |
R3232 |
T13818 |
T13819 |
det |
the,gene |
R3233 |
T13748 |
T13747 |
prep |
in,located |
R3234 |
T13819 |
T13817 |
pobj |
gene,to |
R3235 |
T13820 |
T13821 |
npadvmod |
gene,targeted |
R3236 |
T13821 |
T13819 |
amod |
targeted,gene |
R3237 |
T13749 |
T13750 |
det |
the,region |
R3238 |
T13822 |
T13821 |
punct |
-,targeted |
R3239 |
T13823 |
T13819 |
compound |
mutant,gene |
R3240 |
T13824 |
T13817 |
cc |
or,to |
R3241 |
T13825 |
T13817 |
conj |
to,to |
R3242 |
T13826 |
T13827 |
det |
the,genes |
R3243 |
T13827 |
T13825 |
pobj |
genes,to |
R3244 |
T13750 |
T13748 |
pobj |
region,in |
R3245 |
T13828 |
T13827 |
amod |
normal,genes |
R3246 |
T13829 |
T13827 |
nummod |
129,genes |
R3247 |
T13830 |
T13827 |
acl |
expressed,genes |
R3248 |
T13751 |
T13750 |
amod |
same,region |
R3249 |
T13831 |
T13830 |
prep |
in,expressed |
R3250 |
T13832 |
T13833 |
det |
the,region |
R3251 |
T13833 |
T13831 |
pobj |
region,in |
R3252 |
T13752 |
T13750 |
nmod |
Chromosome,region |
R3253 |
T13834 |
T13833 |
amod |
same,region |
R3254 |
T13835 |
T13833 |
prep |
as,region |
R3255 |
T13753 |
T13752 |
nummod |
1,Chromosome |
R3256 |
T13836 |
T13837 |
det |
the,gene |
R3257 |
T13837 |
T13835 |
pobj |
gene,as |
R3258 |
T13838 |
T13837 |
amod |
targeted,gene |
R3259 |
T13754 |
T13755 |
dep |
that,implicated |
R3260 |
T13839 |
T13801 |
punct |
.,has |
R3261 |
T13755 |
T13746 |
relcl |
implicated,genes |
R3264 |
T13756 |
T13755 |
aux |
have,implicated |
R3267 |
T13757 |
T13755 |
auxpass |
been,implicated |
R3271 |
T13758 |
T13755 |
prep |
in,implicated |
R3275 |
T13759 |
T13760 |
det |
the,development |
R3278 |
T13760 |
T13758 |
pobj |
development,in |
R3282 |
T13761 |
T13760 |
prep |
of,development |
R3285 |
T13762 |
T13761 |
pobj |
SLE,of |
R3289 |
T13763 |
T13764 |
advmod |
when,inactivated |
R3295 |
T13764 |
T13755 |
advcl |
inactivated,implicated |
R3299 |
T13765 |
T13764 |
agent |
by,inactivated |
R3301 |
T13766 |
T13765 |
pobj |
gene,by |
R3304 |
T13767 |
T13766 |
punct |
-,gene |
R3308 |
T13768 |
T13766 |
amod |
targeting,gene |
R3312 |
T13769 |
T13764 |
prep |
in,inactivated |
R3316 |
T13770 |
T13771 |
nummod |
129,cells |
R3320 |
T13771 |
T13769 |
pobj |
cells,in |
R3323 |
T13772 |
T13771 |
amod |
embryonic,cells |
R3324 |
T13773 |
T13771 |
compound |
stem,cells |
R3328 |
T13774 |
T13764 |
cc |
and,inactivated |
R3331 |
T13775 |
T13776 |
advmod |
then,backcrossed |
R3334 |
T13776 |
T13764 |
conj |
backcrossed,inactivated |
R3338 |
T13777 |
T13776 |
prep |
onto,backcrossed |
R3341 |
T13778 |
T13779 |
det |
a,background |
R3347 |
T13779 |
T13777 |
pobj |
background,onto |
R3349 |
T13780 |
T13779 |
amod |
pure,background |
R3353 |
T13781 |
T13779 |
amod |
genetic,background |
R3356 |
T13782 |
T13783 |
punct |
(,Bolland |
R3360 |
T13783 |
T13764 |
meta |
Bolland,inactivated |
R3362 |
T13784 |
T13783 |
cc |
and,Bolland |
R3363 |
T13785 |
T13783 |
conj |
Ravetch,Bolland |
R3364 |
T13786 |
T13785 |
nummod |
2000,Ravetch |
R3367 |
T13787 |
T13785 |
punct |
;,Ravetch |
R3371 |
T13788 |
T13785 |
conj |
Miwa,Ravetch |
R3374 |
T13789 |
T13788 |
nmod |
et,Miwa |
R3378 |
T13790 |
T13788 |
nmod |
al.,Miwa |
R3382 |
T13791 |
T13788 |
nummod |
2002,Miwa |
R3385 |
T13792 |
T13788 |
punct |
;,Miwa |
R3389 |
T13793 |
T13788 |
conj |
Wu,Miwa |
R3391 |
T13794 |
T13793 |
nmod |
et,Wu |
R3392 |
T13795 |
T13793 |
nmod |
al.,Wu |
R3398 |
T13796 |
T13793 |
nummod |
2002,Wu |
R3401 |
T13797 |
T13793 |
punct |
),Wu |
R3403 |
T13798 |
T13743 |
punct |
.,applies |
R3407 |
T13800 |
T13801 |
prep |
For,has |
R3412 |
T13802 |
T13800 |
pobj |
each,For |
R3417 |
T13803 |
T13801 |
punct |
", ",has |
R3421 |
T13804 |
T13801 |
expl |
there,has |
R3425 |
T13805 |
T13806 |
aux |
to,be |
R3429 |
T13806 |
T13801 |
xcomp |
be,has |
R3433 |
T13807 |
T13808 |
det |
a,question |
R3437 |
T13808 |
T13806 |
attr |
question,be |
R3439 |
T13809 |
T13808 |
prep |
as,question |
R3440 |
T13810 |
T13809 |
prep |
to,as |
R3443 |
T13811 |
T13812 |
mark |
whether,is |