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PMC:509305 / 21790-33049 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T13555 11-16 EX denotes There
T13556 17-19 VBZ denotes is
T13557 20-32 VBG denotes accumulating
T13558 33-41 NN denotes evidence
T13559 42-46 IN denotes that
T13561 47-57 NN denotes background
T13562 58-63 NNS denotes genes
T13563 64-67 MD denotes may
T13560 68-77 VB denotes influence
T13564 78-81 DT denotes the
T13565 82-92 NN denotes expression
T13566 93-95 IN denotes of
T13567 96-108 NN denotes autoimmunity
T13568 109-111 IN denotes in
T13569 112-116 NN denotes gene
T13571 116-117 HYPH denotes -
T13570 117-125 VBN denotes targeted
T13572 126-130 NNS denotes mice
T13573 130-131 . denotes .
T13574 131-291 sentence denotes Here we report what is to our knowledge the first systematic study that has examined this in the 129 and C57BL/6 mouse strains, widely used for gene targeting.
T13575 132-136 RB denotes Here
T13577 137-139 PRP denotes we
T13576 140-146 VBP denotes report
T13578 147-151 WP denotes what
T13579 152-154 VBZ denotes is
T13580 155-157 IN denotes to
T13581 158-161 PRP$ denotes our
T13582 162-171 NN denotes knowledge
T13583 172-175 DT denotes the
T13585 176-181 JJ denotes first
T13586 182-192 JJ denotes systematic
T13584 193-198 NN denotes study
T13587 199-203 WDT denotes that
T13589 204-207 VBZ denotes has
T13588 208-216 VBN denotes examined
T13590 217-221 DT denotes this
T13591 222-224 IN denotes in
T13592 225-228 DT denotes the
T13594 229-232 CD denotes 129
T13595 233-236 CC denotes and
T13596 237-242 NN denotes C57BL
T13597 242-243 HYPH denotes /
T13598 243-244 CD denotes 6
T13599 245-250 NN denotes mouse
T13593 251-258 NNS denotes strains
T13600 258-260 , denotes ,
T13601 260-266 RB denotes widely
T13602 267-271 VBN denotes used
T13603 272-275 IN denotes for
T13604 276-280 NN denotes gene
T13605 281-290 NN denotes targeting
T13606 290-291 . denotes .
T13607 291-491 sentence denotes Our results demonstrate interacting loci between 129 and C57BL/6 mice that can cause the expression of a powerful autoimmune phenotype in these animals, in the absence of any gene-targeted mutations.
T13608 292-295 PRP$ denotes Our
T13609 296-303 NNS denotes results
T13610 304-315 VBP denotes demonstrate
T13611 316-327 VBG denotes interacting
T13612 328-332 NNS denotes loci
T13613 333-340 IN denotes between
T13614 341-344 CD denotes 129
T13616 345-348 CC denotes and
T13617 349-354 NN denotes C57BL
T13618 354-355 HYPH denotes /
T13619 355-356 CD denotes 6
T13615 357-361 NNS denotes mice
T13620 362-366 WDT denotes that
T13622 367-370 MD denotes can
T13621 371-376 VB denotes cause
T13623 377-380 DT denotes the
T13624 381-391 NN denotes expression
T13625 392-394 IN denotes of
T13626 395-396 DT denotes a
T13628 397-405 JJ denotes powerful
T13629 406-416 JJ denotes autoimmune
T13627 417-426 NN denotes phenotype
T13630 427-429 IN denotes in
T13631 430-435 DT denotes these
T13632 436-443 NNS denotes animals
T13633 443-445 , denotes ,
T13634 445-447 IN denotes in
T13635 448-451 DT denotes the
T13636 452-459 NN denotes absence
T13637 460-462 IN denotes of
T13638 463-466 DT denotes any
T13640 467-471 NN denotes gene
T13642 471-472 HYPH denotes -
T13641 472-480 VBN denotes targeted
T13639 481-490 NNS denotes mutations
T13643 490-491 . denotes .
T13644 491-686 sentence denotes We also developed a congenic mouse strain bearing a portion of 129 Chromosome 1 on a C57BL/6 background and showed that this wild-type congenic line expressed striking anti-nuclear autoimmunity.
T13645 492-494 PRP denotes We
T13647 495-499 RB denotes also
T13646 500-509 VBD denotes developed
T13648 510-511 DT denotes a
T13650 512-520 JJ denotes congenic
T13651 521-526 NN denotes mouse
T13649 527-533 NN denotes strain
T13652 534-541 VBG denotes bearing
T13653 542-543 DT denotes a
T13654 544-551 NN denotes portion
T13655 552-554 IN denotes of
T13656 555-558 CD denotes 129
T13657 559-569 NN denotes Chromosome
T13658 570-571 CD denotes 1
T13659 572-574 IN denotes on
T13660 575-576 DT denotes a
T13662 577-582 NN denotes C57BL
T13663 582-583 HYPH denotes /
T13664 583-584 CD denotes 6
T13661 585-595 NN denotes background
T13665 596-599 CC denotes and
T13666 600-606 VBD denotes showed
T13667 607-611 IN denotes that
T13669 612-616 DT denotes this
T13671 617-621 JJ denotes wild
T13673 621-622 HYPH denotes -
T13672 622-626 NN denotes type
T13674 627-635 JJ denotes congenic
T13670 636-640 NN denotes line
T13668 641-650 VBD denotes expressed
T13675 651-659 JJ denotes striking
T13677 660-672 JJ denotes anti-nuclear
T13676 673-685 NN denotes autoimmunity
T13678 685-686 . denotes .
T13679 686-1045 sentence denotes By comparing this Chromosome 1 congenic strain with matched congenic mice lacking the Apcs gene, we demonstrated that serum amyloid P component deficiency influences the severity of glomerulonephritis, but is not the prime mover in the induction of anti-nuclear autoimmunity, contrary to our own original interpretation of our data (Bickerstaff et al. 1999).
T13680 687-689 IN denotes By
T13682 690-699 VBG denotes comparing
T13683 700-704 DT denotes this
T13685 705-715 NN denotes Chromosome
T13686 716-717 CD denotes 1
T13687 718-726 JJ denotes congenic
T13684 727-733 NN denotes strain
T13688 734-738 IN denotes with
T13689 739-746 VBN denotes matched
T13691 747-755 JJ denotes congenic
T13690 756-760 NNS denotes mice
T13692 761-768 VBG denotes lacking
T13693 769-772 DT denotes the
T13695 773-777 NN denotes Apcs
T13694 778-782 NN denotes gene
T13696 782-784 , denotes ,
T13697 784-786 PRP denotes we
T13681 787-799 VBD denotes demonstrated
T13698 800-804 IN denotes that
T13700 805-810 NN denotes serum
T13702 811-818 NN denotes amyloid
T13703 819-820 NN denotes P
T13701 821-830 NN denotes component
T13704 831-841 NN denotes deficiency
T13699 842-852 VBZ denotes influences
T13705 853-856 DT denotes the
T13706 857-865 NN denotes severity
T13707 866-868 IN denotes of
T13708 869-887 NN denotes glomerulonephritis
T13709 887-889 , denotes ,
T13710 889-892 CC denotes but
T13711 893-895 VBZ denotes is
T13712 896-899 RB denotes not
T13713 900-903 DT denotes the
T13715 904-909 JJ denotes prime
T13714 910-915 NN denotes mover
T13716 916-918 IN denotes in
T13717 919-922 DT denotes the
T13718 923-932 NN denotes induction
T13719 933-935 IN denotes of
T13720 936-948 JJ denotes anti-nuclear
T13721 949-961 NN denotes autoimmunity
T13722 961-963 , denotes ,
T13723 963-971 JJ denotes contrary
T13724 972-974 IN denotes to
T13725 975-978 PRP$ denotes our
T13727 979-982 JJ denotes own
T13728 983-991 JJ denotes original
T13726 992-1006 NN denotes interpretation
T13729 1007-1009 IN denotes of
T13730 1010-1013 PRP$ denotes our
T13731 1014-1018 NNS denotes data
T13732 1019-1020 -LRB- denotes (
T13733 1020-1031 NNP denotes Bickerstaff
T13734 1032-1034 FW denotes et
T13735 1035-1038 FW denotes al.
T13736 1039-1043 CD denotes 1999
T13737 1043-1044 -RRB- denotes )
T13738 1044-1045 . denotes .
T13739 1045-1360 sentence denotes The same consideration applies to other genes located in the same Chromosome 1 region that have been implicated in the development of SLE when inactivated by gene-targeting in 129 embryonic stem cells and then backcrossed onto a pure genetic background (Bolland and Ravetch 2000; Miwa et al. 2002; Wu et al. 2002).
T13740 1046-1049 DT denotes The
T13742 1050-1054 JJ denotes same
T13741 1055-1068 NN denotes consideration
T13743 1069-1076 VBZ denotes applies
T13744 1077-1079 IN denotes to
T13745 1080-1085 JJ denotes other
T13746 1086-1091 NNS denotes genes
T13747 1092-1099 VBN denotes located
T13748 1100-1102 IN denotes in
T13749 1103-1106 DT denotes the
T13751 1107-1111 JJ denotes same
T13752 1112-1122 NN denotes Chromosome
T13753 1123-1124 CD denotes 1
T13750 1125-1131 NN denotes region
T13754 1132-1136 WDT denotes that
T13756 1137-1141 VBP denotes have
T13757 1142-1146 VBN denotes been
T13755 1147-1157 VBN denotes implicated
T13758 1158-1160 IN denotes in
T13759 1161-1164 DT denotes the
T13760 1165-1176 NN denotes development
T13761 1177-1179 IN denotes of
T13762 1180-1183 NN denotes SLE
T13763 1184-1188 WRB denotes when
T13764 1189-1200 VBN denotes inactivated
T13765 1201-1203 IN denotes by
T13766 1204-1208 NN denotes gene
T13767 1208-1209 HYPH denotes -
T13768 1209-1218 VBG denotes targeting
T13769 1219-1221 IN denotes in
T13770 1222-1225 CD denotes 129
T13772 1226-1235 JJ denotes embryonic
T13773 1236-1240 NN denotes stem
T13771 1241-1246 NNS denotes cells
T13774 1247-1250 CC denotes and
T13775 1251-1255 RB denotes then
T13776 1256-1267 VBD denotes backcrossed
T13777 1268-1272 IN denotes onto
T13778 1273-1274 DT denotes a
T13780 1275-1279 JJ denotes pure
T13781 1280-1287 JJ denotes genetic
T13779 1288-1298 NN denotes background
T13782 1299-1300 -LRB- denotes (
T13783 1300-1307 NNP denotes Bolland
T13784 1308-1311 CC denotes and
T13785 1312-1319 NNP denotes Ravetch
T13786 1320-1324 CD denotes 2000
T13787 1324-1325 : denotes ;
T13788 1326-1330 NNP denotes Miwa
T13789 1331-1333 FW denotes et
T13790 1334-1337 FW denotes al.
T13791 1338-1342 CD denotes 2002
T13792 1342-1343 : denotes ;
T13793 1344-1346 NNP denotes Wu
T13794 1347-1349 FW denotes et
T13795 1350-1353 FW denotes al.
T13796 1354-1358 CD denotes 2002
T13797 1358-1359 -RRB- denotes )
T13798 1359-1360 . denotes .
T13799 1360-1559 sentence denotes For each, there has to be a question as to whether the anti-nuclear autoimmunity is due to the gene-targeted mutant gene or to the normal 129 genes expressed in the same region as the targeted gene.
T13800 1361-1364 IN denotes For
T13802 1365-1369 DT denotes each
T13803 1369-1371 , denotes ,
T13804 1371-1376 EX denotes there
T13801 1377-1380 VBZ denotes has
T13805 1381-1383 TO denotes to
T13806 1384-1386 VB denotes be
T13807 1387-1388 DT denotes a
T13808 1389-1397 NN denotes question
T13809 1398-1400 IN denotes as
T13810 1401-1403 IN denotes to
T13811 1404-1411 IN denotes whether
T13813 1412-1415 DT denotes the
T13815 1416-1428 JJ denotes anti-nuclear
T13814 1429-1441 NN denotes autoimmunity
T13812 1442-1444 VBZ denotes is
T13816 1445-1448 IN denotes due
T13817 1449-1451 IN denotes to
T13818 1452-1455 DT denotes the
T13820 1456-1460 NN denotes gene
T13822 1460-1461 HYPH denotes -
T13821 1461-1469 VBN denotes targeted
T13823 1470-1476 NN denotes mutant
T13819 1477-1481 NN denotes gene
T13824 1482-1484 CC denotes or
T13825 1485-1487 IN denotes to
T13826 1488-1491 DT denotes the
T13828 1492-1498 JJ denotes normal
T13829 1499-1502 CD denotes 129
T13827 1503-1508 NNS denotes genes
T13830 1509-1518 VBN denotes expressed
T13831 1519-1521 IN denotes in
T13832 1522-1525 DT denotes the
T13834 1526-1530 JJ denotes same
T13833 1531-1537 NN denotes region
T13835 1538-1540 IN denotes as
T13836 1541-1544 DT denotes the
T13838 1545-1553 VBN denotes targeted
T13837 1554-1558 NN denotes gene
T13839 1558-1559 . denotes .
T13840 1559-1734 sentence denotes The influence of background genes on the development of spontaneous autoimmune disease is well known, especially with respect to the lpr and Yaa disease-susceptibility genes.
T13841 1560-1563 DT denotes The
T13842 1564-1573 NN denotes influence
T13844 1574-1576 IN denotes of
T13845 1577-1587 NN denotes background
T13846 1588-1593 NNS denotes genes
T13847 1594-1596 IN denotes on
T13848 1597-1600 DT denotes the
T13849 1601-1612 NN denotes development
T13850 1613-1615 IN denotes of
T13851 1616-1627 JJ denotes spontaneous
T13853 1628-1638 JJ denotes autoimmune
T13852 1639-1646 NN denotes disease
T13843 1647-1649 VBZ denotes is
T13854 1650-1654 RB denotes well
T13855 1655-1660 VBN denotes known
T13856 1660-1662 , denotes ,
T13857 1662-1672 RB denotes especially
T13858 1673-1677 IN denotes with
T13859 1678-1685 NN denotes respect
T13860 1686-1688 IN denotes to
T13861 1689-1692 DT denotes the
T13863 1693-1696 NN denotes lpr
T13864 1697-1700 CC denotes and
T13865 1701-1704 NN denotes Yaa
T13866 1705-1712 NN denotes disease
T13868 1712-1713 HYPH denotes -
T13867 1713-1727 NN denotes susceptibility
T13862 1728-1733 NNS denotes genes
T13869 1733-1734 . denotes .
T13870 1734-1941 sentence denotes In MRL/Mp mice, the presence of the lpr gene accelerates the development of high level and broad-spectrum auto-Ab production and lethal glomerulonephritis, in addition to marked lymphoproliferative disease.
T13871 1735-1737 IN denotes In
T13873 1738-1741 NN denotes MRL
T13875 1741-1742 HYPH denotes /
T13874 1742-1744 NN denotes Mp
T13876 1745-1749 NNS denotes mice
T13877 1749-1751 , denotes ,
T13878 1751-1754 DT denotes the
T13879 1755-1763 NN denotes presence
T13880 1764-1766 IN denotes of
T13881 1767-1770 DT denotes the
T13883 1771-1774 NN denotes lpr
T13882 1775-1779 NN denotes gene
T13872 1780-1791 VBZ denotes accelerates
T13884 1792-1795 DT denotes the
T13885 1796-1807 NN denotes development
T13886 1808-1810 IN denotes of
T13887 1811-1815 JJ denotes high
T13888 1816-1821 NN denotes level
T13890 1822-1825 CC denotes and
T13891 1826-1831 NN denotes broad
T13893 1831-1832 HYPH denotes -
T13892 1832-1840 NN denotes spectrum
T13894 1841-1848 NN denotes auto-Ab
T13889 1849-1859 NN denotes production
T13895 1860-1863 CC denotes and
T13896 1864-1870 JJ denotes lethal
T13897 1871-1889 NN denotes glomerulonephritis
T13898 1889-1891 , denotes ,
T13899 1891-1893 IN denotes in
T13900 1894-1902 NN denotes addition
T13901 1903-1905 IN denotes to
T13902 1906-1912 JJ denotes marked
T13904 1913-1932 JJ denotes lymphoproliferative
T13903 1933-1940 NN denotes disease
T13905 1940-1941 . denotes .
T13906 1941-2089 sentence denotes In contrast, homozygosity of the lpr gene in other strains such as C57BL/6, AKR, LG/J, and C3H leads only to auto-Ab production (Izui et al. 1984).
T13907 1942-1944 IN denotes In
T13909 1945-1953 NN denotes contrast
T13910 1953-1955 , denotes ,
T13911 1955-1967 NN denotes homozygosity
T13912 1968-1970 IN denotes of
T13913 1971-1974 DT denotes the
T13915 1975-1978 NN denotes lpr
T13914 1979-1983 NN denotes gene
T13916 1984-1986 IN denotes in
T13917 1987-1992 JJ denotes other
T13918 1993-2000 NNS denotes strains
T13919 2001-2005 JJ denotes such
T13920 2006-2008 IN denotes as
T13921 2009-2014 NN denotes C57BL
T13922 2014-2015 HYPH denotes /
T13923 2015-2016 CD denotes 6
T13924 2016-2018 , denotes ,
T13925 2018-2021 NN denotes AKR
T13926 2021-2023 , denotes ,
T13927 2023-2025 NN denotes LG
T13929 2025-2026 HYPH denotes /
T13928 2026-2027 NN denotes J
T13930 2027-2029 , denotes ,
T13931 2029-2032 CC denotes and
T13932 2033-2036 NN denotes C3H
T13908 2037-2042 VBZ denotes leads
T13933 2043-2047 RB denotes only
T13934 2048-2050 IN denotes to
T13935 2051-2058 NN denotes auto-Ab
T13936 2059-2069 NN denotes production
T13937 2070-2071 -LRB- denotes (
T13938 2071-2075 NNP denotes Izui
T13939 2076-2078 FW denotes et
T13940 2079-2082 FW denotes al.
T13941 2083-2087 CD denotes 1984
T13942 2087-2088 -RRB- denotes )
T13943 2088-2089 . denotes .
T13944 2089-2264 sentence denotes Similarly, the Y-chromosome-linked Yaa gene in BXSB and MRL/Mp males enhances the rapid development of auto-Abs and glomerulonephritis (Izui et al. 1988; Merino et al. 1989).
T13945 2090-2099 RB denotes Similarly
T13947 2099-2101 , denotes ,
T13948 2101-2104 DT denotes the
T13950 2105-2106 NN denotes Y
T13952 2106-2107 HYPH denotes -
T13951 2107-2117 NN denotes chromosome
T13954 2117-2118 HYPH denotes -
T13953 2118-2124 VBN denotes linked
T13955 2125-2128 NN denotes Yaa
T13949 2129-2133 NN denotes gene
T13956 2134-2136 IN denotes in
T13957 2137-2141 NN denotes BXSB
T13959 2142-2145 CC denotes and
T13960 2146-2149 NN denotes MRL
T13962 2149-2150 HYPH denotes /
T13961 2150-2152 NN denotes Mp
T13958 2153-2158 NNS denotes males
T13946 2159-2167 VBZ denotes enhances
T13963 2168-2171 DT denotes the
T13965 2172-2177 JJ denotes rapid
T13964 2178-2189 NN denotes development
T13966 2190-2192 IN denotes of
T13967 2193-2201 NNS denotes auto-Abs
T13968 2202-2205 CC denotes and
T13969 2206-2224 NN denotes glomerulonephritis
T13970 2225-2226 -LRB- denotes (
T13971 2226-2230 NNP denotes Izui
T13972 2231-2233 FW denotes et
T13973 2234-2237 FW denotes al.
T13974 2238-2242 CD denotes 1988
T13975 2242-2243 : denotes ;
T13976 2244-2250 NNP denotes Merino
T13977 2251-2253 FW denotes et
T13978 2254-2257 FW denotes al.
T13979 2258-2262 CD denotes 1989
T13980 2262-2263 -RRB- denotes )
T13981 2263-2264 . denotes .
T13982 2264-2374 sentence denotes However, in the C57BL/6 background, the Yaa gene does not lead to an autoimmune phenotype (Izui et al. 1988).
T13983 2265-2272 RB denotes However
T13985 2272-2274 , denotes ,
T13986 2274-2276 IN denotes in
T13987 2277-2280 DT denotes the
T13989 2281-2286 NN denotes C57BL
T13990 2286-2287 HYPH denotes /
T13991 2287-2288 CD denotes 6
T13988 2289-2299 NN denotes background
T13992 2299-2301 , denotes ,
T13993 2301-2304 DT denotes the
T13995 2305-2308 NN denotes Yaa
T13994 2309-2313 NN denotes gene
T13996 2314-2318 VBZ denotes does
T13997 2319-2322 RB denotes not
T13984 2323-2327 VB denotes lead
T13998 2328-2330 IN denotes to
T13999 2331-2333 DT denotes an
T14001 2334-2344 JJ denotes autoimmune
T14000 2345-2354 NN denotes phenotype
T14002 2355-2356 -LRB- denotes (
T14003 2356-2360 NNP denotes Izui
T14004 2361-2363 FW denotes et
T14005 2364-2367 FW denotes al.
T14006 2368-2372 CD denotes 1988
T14007 2372-2373 -RRB- denotes )
T14008 2373-2374 . denotes .
T14009 2374-2594 sentence denotes Not surprisingly, important effects of the genetic background on the expression of autoimmunity have also been reported in gene-targeted mice (Bolland and Ravetch 2000; Santiago-Raber et al. 2001; Mitchell et al. 2002).
T14010 2375-2378 RB denotes Not
T14011 2379-2391 RB denotes surprisingly
T14013 2391-2393 , denotes ,
T14014 2393-2402 JJ denotes important
T14015 2403-2410 NNS denotes effects
T14016 2411-2413 IN denotes of
T14017 2414-2417 DT denotes the
T14019 2418-2425 JJ denotes genetic
T14018 2426-2436 NN denotes background
T14020 2437-2439 IN denotes on
T14021 2440-2443 DT denotes the
T14022 2444-2454 NN denotes expression
T14023 2455-2457 IN denotes of
T14024 2458-2470 NN denotes autoimmunity
T14025 2471-2475 VBP denotes have
T14026 2476-2480 RB denotes also
T14027 2481-2485 VBN denotes been
T14012 2486-2494 VBN denotes reported
T14028 2495-2497 IN denotes in
T14029 2498-2502 NN denotes gene
T14031 2502-2503 HYPH denotes -
T14030 2503-2511 VBN denotes targeted
T14032 2512-2516 NNS denotes mice
T14033 2517-2518 -LRB- denotes (
T14034 2518-2525 NNP denotes Bolland
T14035 2526-2529 CC denotes and
T14036 2530-2537 NNP denotes Ravetch
T14037 2538-2542 CD denotes 2000
T14038 2542-2543 : denotes ;
T14039 2544-2552 NNP denotes Santiago
T14040 2552-2553 HYPH denotes -
T14041 2553-2558 NNP denotes Raber
T14042 2559-2561 FW denotes et
T14043 2562-2565 FW denotes al.
T14044 2566-2570 CD denotes 2001
T14045 2570-2571 : denotes ;
T14046 2572-2580 NNP denotes Mitchell
T14047 2581-2583 FW denotes et
T14048 2584-2587 FW denotes al.
T14049 2588-2592 CD denotes 2002
T14050 2592-2593 -RRB- denotes )
T14051 2593-2594 . denotes .
T14052 2594-2751 sentence denotes Thus, SLE exists as a complex-trait disorder in which specific combinations of susceptibility alleles are required for the expression of the full phenotype.
T14053 2595-2599 RB denotes Thus
T14055 2599-2601 , denotes ,
T14056 2601-2604 NN denotes SLE
T14054 2605-2611 VBZ denotes exists
T14057 2612-2614 IN denotes as
T14058 2615-2616 DT denotes a
T14060 2617-2624 JJ denotes complex
T14062 2624-2625 HYPH denotes -
T14061 2625-2630 NN denotes trait
T14059 2631-2639 NN denotes disorder
T14063 2640-2642 IN denotes in
T14065 2643-2648 WDT denotes which
T14066 2649-2657 JJ denotes specific
T14067 2658-2670 NNS denotes combinations
T14068 2671-2673 IN denotes of
T14069 2674-2688 NN denotes susceptibility
T14070 2689-2696 NNS denotes alleles
T14071 2697-2700 VBP denotes are
T14064 2701-2709 VBN denotes required
T14072 2710-2713 IN denotes for
T14073 2714-2717 DT denotes the
T14074 2718-2728 NN denotes expression
T14075 2729-2731 IN denotes of
T14076 2732-2735 DT denotes the
T14078 2736-2740 JJ denotes full
T14077 2741-2750 NN denotes phenotype
T14079 2750-2751 . denotes .
T14080 2751-2904 sentence denotes Through the use of microsatellite marker maps, the identification of murine SLE susceptibility intervals in experimental crosses has been made possible.
T14081 2752-2759 IN denotes Through
T14083 2760-2763 DT denotes the
T14084 2764-2767 NN denotes use
T14085 2768-2770 IN denotes of
T14086 2771-2785 NN denotes microsatellite
T14088 2786-2792 NN denotes marker
T14087 2793-2797 NNS denotes maps
T14089 2797-2799 , denotes ,
T14090 2799-2802 DT denotes the
T14091 2803-2817 NN denotes identification
T14092 2818-2820 IN denotes of
T14093 2821-2827 JJ denotes murine
T14095 2828-2831 NN denotes SLE
T14096 2832-2846 NN denotes susceptibility
T14094 2847-2856 NNS denotes intervals
T14097 2857-2859 IN denotes in
T14098 2860-2872 JJ denotes experimental
T14099 2873-2880 NNS denotes crosses
T14100 2881-2884 VBZ denotes has
T14101 2885-2889 VBN denotes been
T14082 2890-2894 VBN denotes made
T14102 2895-2903 JJ denotes possible
T14103 2903-2904 . denotes .
T14104 2904-3208 sentence denotes These mapping studies have shown that the disease expression in relation to the inheritance of the different alleles followed a threshold liability pattern in which a positive phenotype depended upon the presence of multiple discrete susceptibility loci with no single locus being a prerequisite factor.
T14105 2905-2910 DT denotes These
T14107 2911-2918 NN denotes mapping
T14106 2919-2926 NNS denotes studies
T14109 2927-2931 VBP denotes have
T14108 2932-2937 VBN denotes shown
T14110 2938-2942 IN denotes that
T14112 2943-2946 DT denotes the
T14114 2947-2954 NN denotes disease
T14113 2955-2965 NN denotes expression
T14115 2966-2968 IN denotes in
T14116 2969-2977 NN denotes relation
T14117 2978-2980 IN denotes to
T14118 2981-2984 DT denotes the
T14119 2985-2996 NN denotes inheritance
T14120 2997-2999 IN denotes of
T14121 3000-3003 DT denotes the
T14123 3004-3013 JJ denotes different
T14122 3014-3021 NNS denotes alleles
T14111 3022-3030 VBD denotes followed
T14124 3031-3032 DT denotes a
T14126 3033-3042 NN denotes threshold
T14127 3043-3052 NN denotes liability
T14125 3053-3060 NN denotes pattern
T14128 3061-3063 IN denotes in
T14130 3064-3069 WDT denotes which
T14131 3070-3071 DT denotes a
T14133 3072-3080 JJ denotes positive
T14132 3081-3090 NN denotes phenotype
T14129 3091-3099 VBD denotes depended
T14134 3100-3104 IN denotes upon
T14135 3105-3108 DT denotes the
T14136 3109-3117 NN denotes presence
T14137 3118-3120 IN denotes of
T14138 3121-3129 JJ denotes multiple
T14140 3130-3138 JJ denotes discrete
T14141 3139-3153 NN denotes susceptibility
T14139 3154-3158 NNS denotes loci
T14142 3159-3163 IN denotes with
T14143 3164-3166 DT denotes no
T14145 3167-3173 JJ denotes single
T14144 3174-3179 NN denotes locus
T14146 3180-3185 VBG denotes being
T14147 3186-3187 DT denotes a
T14149 3188-3200 JJ denotes prerequisite
T14148 3201-3207 NN denotes factor
T14150 3207-3208 . denotes .
T14151 3208-3391 sentence denotes We have employed the same approach to analyse the genetic basis of disease inheritance in the (129 × C57BL/6) hybrid strain, the most common genetic background in gene-targeted mice.
T14152 3209-3211 PRP denotes We
T14154 3212-3216 VBP denotes have
T14153 3217-3225 VBN denotes employed
T14155 3226-3229 DT denotes the
T14157 3230-3234 JJ denotes same
T14156 3235-3243 NN denotes approach
T14158 3244-3246 TO denotes to
T14159 3247-3254 VB denotes analyse
T14160 3255-3258 DT denotes the
T14162 3259-3266 JJ denotes genetic
T14161 3267-3272 NN denotes basis
T14163 3273-3275 IN denotes of
T14164 3276-3283 NN denotes disease
T14165 3284-3295 NN denotes inheritance
T14166 3296-3298 IN denotes in
T14167 3299-3302 DT denotes the
T14169 3303-3304 -LRB- denotes (
T14170 3304-3307 CD denotes 129
T14171 3308-3309 SYM denotes ×
T14172 3310-3315 NN denotes C57BL
T14173 3315-3316 HYPH denotes /
T14174 3316-3317 CD denotes 6
T14175 3317-3318 -RRB- denotes )
T14176 3319-3325 NN denotes hybrid
T14168 3326-3332 NN denotes strain
T14177 3332-3334 , denotes ,
T14178 3334-3337 DT denotes the
T14180 3338-3342 RBS denotes most
T14181 3343-3349 JJ denotes common
T14182 3350-3357 JJ denotes genetic
T14179 3358-3368 NN denotes background
T14183 3369-3371 IN denotes in
T14184 3372-3376 NN denotes gene
T14186 3376-3377 HYPH denotes -
T14185 3377-3385 VBN denotes targeted
T14187 3386-3390 NNS denotes mice
T14188 3390-3391 . denotes .
T14189 3391-3872 sentence denotes Although spontaneous autoimmunity has not been documented in either of the pure 129 or C57BL/6 strains, a spontaneous lupus-like phenotype has been described in (129 × C57BL/6) hybrid strains (Obata et al. 1979; Botto et al. 1998; Bickerstaff et al. 1999; Santiago-Raber et al. 2001), suggesting that the predisposition in these hybrid mice may arise as a result of the interaction between specific combinations of alleles inherited from both the 129 and C57BL/6 parental strains.
T14190 3392-3400 IN denotes Although
T14192 3401-3412 JJ denotes spontaneous
T14193 3413-3425 NN denotes autoimmunity
T14194 3426-3429 VBZ denotes has
T14195 3430-3433 RB denotes not
T14196 3434-3438 VBN denotes been
T14191 3439-3449 VBN denotes documented
T14198 3450-3452 IN denotes in
T14199 3453-3459 DT denotes either
T14200 3460-3462 IN denotes of
T14201 3463-3466 DT denotes the
T14203 3467-3471 JJ denotes pure
T14204 3472-3475 CD denotes 129
T14205 3476-3478 CC denotes or
T14206 3479-3484 NN denotes C57BL
T14207 3484-3485 HYPH denotes /
T14208 3485-3486 CD denotes 6
T14202 3487-3494 NNS denotes strains
T14209 3494-3496 , denotes ,
T14210 3496-3497 DT denotes a
T14212 3498-3509 JJ denotes spontaneous
T14213 3510-3515 NN denotes lupus
T14215 3515-3516 HYPH denotes -
T14214 3516-3520 JJ denotes like
T14211 3521-3530 NN denotes phenotype
T14216 3531-3534 VBZ denotes has
T14217 3535-3539 VBN denotes been
T14197 3540-3549 VBN denotes described
T14218 3550-3552 IN denotes in
T14219 3553-3554 -LRB- denotes (
T14221 3554-3557 CD denotes 129
T14222 3558-3559 SYM denotes ×
T14223 3560-3565 NN denotes C57BL
T14224 3565-3566 HYPH denotes /
T14225 3566-3567 CD denotes 6
T14226 3567-3568 -RRB- denotes )
T14227 3569-3575 NN denotes hybrid
T14220 3576-3583 NNS denotes strains
T14228 3584-3585 -LRB- denotes (
T14229 3585-3590 NNP denotes Obata
T14230 3591-3593 FW denotes et
T14231 3594-3597 FW denotes al.
T14232 3598-3602 CD denotes 1979
T14233 3602-3603 : denotes ;
T14234 3604-3609 NNP denotes Botto
T14235 3610-3612 FW denotes et
T14236 3613-3616 FW denotes al.
T14237 3617-3621 CD denotes 1998
T14238 3621-3622 : denotes ;
T14239 3623-3634 NNP denotes Bickerstaff
T14240 3635-3637 FW denotes et
T14241 3638-3641 FW denotes al.
T14242 3642-3646 CD denotes 1999
T14243 3646-3647 : denotes ;
T14244 3648-3656 NNP denotes Santiago
T14245 3656-3657 HYPH denotes -
T14246 3657-3662 NNP denotes Raber
T14247 3663-3665 FW denotes et
T14248 3666-3669 FW denotes al.
T14249 3670-3674 CD denotes 2001
T14250 3674-3675 -RRB- denotes )
T14251 3675-3677 , denotes ,
T14252 3677-3687 VBG denotes suggesting
T14253 3688-3692 IN denotes that
T14255 3693-3696 DT denotes the
T14256 3697-3711 NN denotes predisposition
T14257 3712-3714 IN denotes in
T14258 3715-3720 DT denotes these
T14260 3721-3727 JJ denotes hybrid
T14259 3728-3732 NNS denotes mice
T14261 3733-3736 MD denotes may
T14254 3737-3742 VB denotes arise
T14262 3743-3745 IN denotes as
T14263 3746-3747 DT denotes a
T14264 3748-3754 NN denotes result
T14265 3755-3757 IN denotes of
T14266 3758-3761 DT denotes the
T14267 3762-3773 NN denotes interaction
T14268 3774-3781 IN denotes between
T14269 3782-3790 JJ denotes specific
T14270 3791-3803 NNS denotes combinations
T14271 3804-3806 IN denotes of
T14272 3807-3814 NNS denotes alleles
T14273 3815-3824 VBN denotes inherited
T14274 3825-3829 IN denotes from
T14275 3830-3834 CC denotes both
T14277 3835-3838 DT denotes the
T14278 3839-3842 CD denotes 129
T14279 3843-3846 CC denotes and
T14280 3847-3852 NN denotes C57BL
T14281 3852-3853 HYPH denotes /
T14282 3853-3854 CD denotes 6
T14283 3855-3863 JJ denotes parental
T14276 3864-3871 NNS denotes strains
T14284 3871-3872 . denotes .
T14285 3872-3927 sentence denotes This was confirmed by the mapping study reported here.
T14286 3873-3877 DT denotes This
T14288 3878-3881 VBD denotes was
T14287 3882-3891 VBN denotes confirmed
T14289 3892-3894 IN denotes by
T14290 3895-3898 DT denotes the
T14292 3899-3906 NN denotes mapping
T14291 3907-3912 NN denotes study
T14293 3913-3921 VBN denotes reported
T14294 3922-3926 RB denotes here
T14295 3926-3927 . denotes .
T14296 3927-4056 sentence denotes We showed that there are multiple genetic loci contributing to the disease and these are derived from both 129 and C57BL/6 mice.
T14297 3928-3930 PRP denotes We
T14298 3931-3937 VBD denotes showed
T14299 3938-3942 IN denotes that
T14301 3943-3948 EX denotes there
T14300 3949-3952 VBP denotes are
T14302 3953-3961 JJ denotes multiple
T14304 3962-3969 JJ denotes genetic
T14303 3970-3974 NNS denotes loci
T14305 3975-3987 VBG denotes contributing
T14306 3988-3990 IN denotes to
T14307 3991-3994 DT denotes the
T14308 3995-4002 NN denotes disease
T14309 4003-4006 CC denotes and
T14310 4007-4012 DT denotes these
T14312 4013-4016 VBP denotes are
T14311 4017-4024 VBN denotes derived
T14313 4025-4029 IN denotes from
T14314 4030-4034 CC denotes both
T14315 4035-4038 CD denotes 129
T14317 4039-4042 CC denotes and
T14318 4043-4048 NN denotes C57BL
T14319 4048-4049 HYPH denotes /
T14320 4049-4050 CD denotes 6
T14316 4051-4055 NNS denotes mice
T14321 4055-4056 . denotes .
T14322 4056-4166 sentence denotes We demonstrated that a 129-derived segment of Chromosome 1 was strongly linked to the expression of auto-Abs.
T14323 4057-4059 PRP denotes We
T14324 4060-4072 VBD denotes demonstrated
T14325 4073-4077 IN denotes that
T14327 4078-4079 DT denotes a
T14329 4080-4083 CD denotes 129
T14331 4083-4084 HYPH denotes -
T14330 4084-4091 VBN denotes derived
T14328 4092-4099 NN denotes segment
T14332 4100-4102 IN denotes of
T14333 4103-4113 NN denotes Chromosome
T14334 4114-4115 CD denotes 1
T14326 4116-4119 VBD denotes was
T14335 4120-4128 RB denotes strongly
T14336 4129-4135 VBN denotes linked
T14337 4136-4138 IN denotes to
T14338 4139-4142 DT denotes the
T14339 4143-4153 NN denotes expression
T14340 4154-4156 IN denotes of
T14341 4157-4165 NNS denotes auto-Abs
T14342 4165-4166 . denotes .
T14343 4166-4349 sentence denotes This region is probably capable of causing the initiation of a humoral autoimmune response to nuclear antigens; however, this response does not occur in the absence of C57BL/6 genes.
T14344 4167-4171 DT denotes This
T14345 4172-4178 NN denotes region
T14346 4179-4181 VBZ denotes is
T14348 4182-4190 RB denotes probably
T14349 4191-4198 JJ denotes capable
T14350 4199-4201 IN denotes of
T14351 4202-4209 VBG denotes causing
T14352 4210-4213 DT denotes the
T14353 4214-4224 NN denotes initiation
T14354 4225-4227 IN denotes of
T14355 4228-4229 DT denotes a
T14357 4230-4237 JJ denotes humoral
T14358 4238-4248 JJ denotes autoimmune
T14356 4249-4257 NN denotes response
T14359 4258-4260 IN denotes to
T14360 4261-4268 JJ denotes nuclear
T14361 4269-4277 NNS denotes antigens
T14362 4277-4278 : denotes ;
T14363 4279-4286 RB denotes however
T14364 4286-4288 , denotes ,
T14365 4288-4292 DT denotes this
T14366 4293-4301 NN denotes response
T14367 4302-4306 VBZ denotes does
T14368 4307-4310 RB denotes not
T14347 4311-4316 VB denotes occur
T14369 4317-4319 IN denotes in
T14370 4320-4323 DT denotes the
T14371 4324-4331 NN denotes absence
T14372 4332-4334 IN denotes of
T14373 4335-4340 NN denotes C57BL
T14375 4340-4341 HYPH denotes /
T14376 4341-4342 CD denotes 6
T14374 4343-4348 NNS denotes genes
T14377 4348-4349 . denotes .
T14378 4349-4506 sentence denotes In support of this, we identified a C57BL/6 segment on Chromosome 3, which may interact with the 129 genes on Chromosome 1 to mediate the loss of tolerance.
T14379 4350-4352 IN denotes In
T14381 4353-4360 NN denotes support
T14382 4361-4363 IN denotes of
T14383 4364-4368 DT denotes this
T14384 4368-4370 , denotes ,
T14385 4370-4372 PRP denotes we
T14380 4373-4383 VBD denotes identified
T14386 4384-4385 DT denotes a
T14388 4386-4391 NN denotes C57BL
T14389 4391-4392 HYPH denotes /
T14390 4392-4393 CD denotes 6
T14387 4394-4401 NN denotes segment
T14391 4402-4404 IN denotes on
T14392 4405-4415 NN denotes Chromosome
T14393 4416-4417 CD denotes 3
T14394 4417-4419 , denotes ,
T14395 4419-4424 WDT denotes which
T14397 4425-4428 MD denotes may
T14396 4429-4437 VB denotes interact
T14398 4438-4442 IN denotes with
T14399 4443-4446 DT denotes the
T14401 4447-4450 CD denotes 129
T14400 4451-4456 NNS denotes genes
T14402 4457-4459 IN denotes on
T14403 4460-4470 NN denotes Chromosome
T14404 4471-4472 CD denotes 1
T14405 4473-4475 TO denotes to
T14406 4476-4483 VB denotes mediate
T14407 4484-4487 DT denotes the
T14408 4488-4492 NN denotes loss
T14409 4493-4495 IN denotes of
T14410 4496-4505 NN denotes tolerance
T14411 4505-4506 . denotes .
T14412 4506-4795 sentence denotes Interestingly, although the C57BL/6 SLE-susceptibility region on Chromosome 3 is novel, disease-modifying alleles derived from C57BL/10 and C57BL/6 strains have been mapped to a portion of Chromosome 3 close to the region identified in this study (Morel et al. 1999; Haywood et al. 2000).
T14413 4507-4520 RB denotes Interestingly
T14415 4520-4522 , denotes ,
T14416 4522-4530 IN denotes although
T14418 4531-4534 DT denotes the
T14420 4535-4540 NN denotes C57BL
T14421 4540-4541 HYPH denotes /
T14422 4541-4542 CD denotes 6
T14423 4543-4546 NN denotes SLE
T14425 4546-4547 HYPH denotes -
T14424 4547-4561 NN denotes susceptibility
T14419 4562-4568 NN denotes region
T14426 4569-4571 IN denotes on
T14427 4572-4582 NN denotes Chromosome
T14428 4583-4584 CD denotes 3
T14417 4585-4587 VBZ denotes is
T14429 4588-4593 JJ denotes novel
T14430 4593-4595 , denotes ,
T14431 4595-4602 NN denotes disease
T14433 4602-4603 HYPH denotes -
T14432 4603-4612 VBG denotes modifying
T14434 4613-4620 NNS denotes alleles
T14435 4621-4628 VBN denotes derived
T14436 4629-4633 IN denotes from
T14437 4634-4639 NN denotes C57BL
T14439 4639-4640 HYPH denotes /
T14440 4640-4642 CD denotes 10
T14441 4643-4646 CC denotes and
T14442 4647-4652 NN denotes C57BL
T14443 4652-4653 HYPH denotes /
T14444 4653-4654 CD denotes 6
T14438 4655-4662 NNS denotes strains
T14445 4663-4667 VBP denotes have
T14446 4668-4672 VBN denotes been
T14414 4673-4679 VBN denotes mapped
T14447 4680-4682 IN denotes to
T14448 4683-4684 DT denotes a
T14449 4685-4692 NN denotes portion
T14450 4693-4695 IN denotes of
T14451 4696-4706 NN denotes Chromosome
T14452 4707-4708 CD denotes 3
T14453 4709-4714 JJ denotes close
T14454 4715-4717 IN denotes to
T14455 4718-4721 DT denotes the
T14456 4722-4728 NN denotes region
T14457 4729-4739 VBN denotes identified
T14458 4740-4742 IN denotes in
T14459 4743-4747 DT denotes this
T14460 4748-4753 NN denotes study
T14461 4754-4755 -LRB- denotes (
T14462 4755-4760 NNP denotes Morel
T14463 4761-4763 FW denotes et
T14464 4764-4767 FW denotes al.
T14465 4768-4772 CD denotes 1999
T14466 4772-4773 : denotes ;
T14467 4774-4781 NNP denotes Haywood
T14468 4782-4784 FW denotes et
T14469 4785-4788 FW denotes al.
T14470 4789-4793 CD denotes 2000
T14471 4793-4794 -RRB- denotes )
T14472 4794-4795 . denotes .
T14473 4795-5068 sentence denotes Furthermore, the region on Chromosome 7 associated with the development of lupus nephritis has been linked to the same trait in other murine models of SLE (Santiago et al. 1998; Morel et al. 1999; Xie et al. 2002), suggesting the possibility of shared susceptibility loci.
T14474 4796-4807 RB denotes Furthermore
T14476 4807-4809 , denotes ,
T14477 4809-4812 DT denotes the
T14478 4813-4819 NN denotes region
T14479 4820-4822 IN denotes on
T14480 4823-4833 NN denotes Chromosome
T14481 4834-4835 CD denotes 7
T14482 4836-4846 VBN denotes associated
T14483 4847-4851 IN denotes with
T14484 4852-4855 DT denotes the
T14485 4856-4867 NN denotes development
T14486 4868-4870 IN denotes of
T14487 4871-4876 NN denotes lupus
T14488 4877-4886 NN denotes nephritis
T14489 4887-4890 VBZ denotes has
T14490 4891-4895 VBN denotes been
T14475 4896-4902 VBN denotes linked
T14491 4903-4905 IN denotes to
T14492 4906-4909 DT denotes the
T14494 4910-4914 JJ denotes same
T14493 4915-4920 NN denotes trait
T14495 4921-4923 IN denotes in
T14496 4924-4929 JJ denotes other
T14498 4930-4936 JJ denotes murine
T14497 4937-4943 NNS denotes models
T14499 4944-4946 IN denotes of
T14500 4947-4950 NN denotes SLE
T14501 4951-4952 -LRB- denotes (
T14502 4952-4960 NNP denotes Santiago
T14503 4961-4963 FW denotes et
T14504 4964-4967 FW denotes al.
T14505 4968-4972 CD denotes 1998
T14506 4972-4973 : denotes ;
T14507 4974-4979 NNP denotes Morel
T14508 4980-4982 FW denotes et
T14509 4983-4986 FW denotes al.
T14510 4987-4991 CD denotes 1999
T14511 4991-4992 : denotes ;
T14512 4993-4996 NNP denotes Xie
T14513 4997-4999 FW denotes et
T14514 5000-5003 FW denotes al.
T14515 5004-5008 CD denotes 2002
T14516 5008-5009 -RRB- denotes )
T14517 5009-5011 , denotes ,
T14518 5011-5021 VBG denotes suggesting
T14519 5022-5025 DT denotes the
T14520 5026-5037 NN denotes possibility
T14521 5038-5040 IN denotes of
T14522 5041-5047 VBN denotes shared
T14524 5048-5062 NN denotes susceptibility
T14523 5063-5067 NNS denotes loci
T14525 5067-5068 . denotes .
T14526 5068-5319 sentence denotes Taken together our results suggest a complex genetic contribution from the (129 × C57BL/6) hybrid background genome, with both enhancing as well as inhibitory loci from the 129 mouse, in addition to genes promoting autoimmunity from the C57BL/6 mice.
T14527 5069-5074 VBN denotes Taken
T14529 5075-5083 RB denotes together
T14530 5084-5087 PRP$ denotes our
T14531 5088-5095 NNS denotes results
T14528 5096-5103 VBP denotes suggest
T14532 5104-5105 DT denotes a
T14534 5106-5113 JJ denotes complex
T14535 5114-5121 JJ denotes genetic
T14533 5122-5134 NN denotes contribution
T14536 5135-5139 IN denotes from
T14537 5140-5143 DT denotes the
T14539 5144-5145 -LRB- denotes (
T14540 5145-5148 CD denotes 129
T14541 5149-5150 SYM denotes ×
T14542 5151-5156 NN denotes C57BL
T14543 5156-5157 HYPH denotes /
T14544 5157-5158 CD denotes 6
T14545 5158-5159 -RRB- denotes )
T14546 5160-5166 JJ denotes hybrid
T14547 5167-5177 NN denotes background
T14538 5178-5184 NN denotes genome
T14548 5184-5186 , denotes ,
T14549 5186-5190 IN denotes with
T14550 5191-5195 DT denotes both
T14552 5196-5205 VBG denotes enhancing
T14553 5206-5208 RB denotes as
T14555 5209-5213 RB denotes well
T14554 5214-5216 IN denotes as
T14556 5217-5227 JJ denotes inhibitory
T14551 5228-5232 NNS denotes loci
T14557 5233-5237 IN denotes from
T14558 5238-5241 DT denotes the
T14560 5242-5245 CD denotes 129
T14559 5246-5251 NN denotes mouse
T14561 5251-5253 , denotes ,
T14562 5253-5255 IN denotes in
T14563 5256-5264 NN denotes addition
T14564 5265-5267 IN denotes to
T14565 5268-5273 NNS denotes genes
T14566 5274-5283 VBG denotes promoting
T14567 5284-5296 NN denotes autoimmunity
T14568 5297-5301 IN denotes from
T14569 5302-5305 DT denotes the
T14571 5306-5311 NN denotes C57BL
T14572 5311-5312 HYPH denotes /
T14573 5312-5313 CD denotes 6
T14570 5314-5318 NNS denotes mice
T14574 5318-5319 . denotes .
T14575 5319-5530 sentence denotes The impact that these interacting loci may have on the lupus-like disease present in several gene-targeted animals was further assessed by comparing Apcs −/− mice with Chromosome 1 genetically matched controls.
T14576 5320-5323 DT denotes The
T14577 5324-5330 NN denotes impact
T14579 5331-5335 WDT denotes that
T14581 5336-5341 DT denotes these
T14583 5342-5353 VBG denotes interacting
T14582 5354-5358 NNS denotes loci
T14584 5359-5362 MD denotes may
T14580 5363-5367 VB denotes have
T14585 5368-5370 IN denotes on
T14586 5371-5374 DT denotes the
T14588 5375-5380 NN denotes lupus
T14590 5380-5381 HYPH denotes -
T14589 5381-5385 JJ denotes like
T14587 5386-5393 NN denotes disease
T14591 5394-5401 JJ denotes present
T14592 5402-5404 IN denotes in
T14593 5405-5412 JJ denotes several
T14595 5413-5417 NN denotes gene
T14597 5417-5418 HYPH denotes -
T14596 5418-5426 VBN denotes targeted
T14594 5427-5434 NNS denotes animals
T14598 5435-5438 VBD denotes was
T14599 5439-5446 RB denotes further
T14578 5447-5455 VBN denotes assessed
T14600 5456-5458 IN denotes by
T14601 5459-5468 VBG denotes comparing
T14602 5469-5473 NN denotes Apcs
T14604 5474-5475 SYM denotes −
T14605 5475-5476 HYPH denotes /
T14606 5476-5477 SYM denotes −
T14603 5478-5482 NNS denotes mice
T14607 5483-5487 IN denotes with
T14608 5488-5498 NN denotes Chromosome
T14610 5499-5500 CD denotes 1
T14611 5501-5512 RB denotes genetically
T14609 5513-5520 VBN denotes matched
T14612 5521-5529 NNS denotes controls
T14613 5529-5530 . denotes .
T14614 5530-5880 sentence denotes In the context of SLE susceptibility, one of the most consistently mapped non-MHC regions of the mouse genome is the telomeric Chromosome 1 segment, where several disease loci, designated Sle1 (Morel et al. 2001), Nba2 (Drake et al. 1995; Rozzo et al. 1996; Vyse et al. 1997), and Bxs3 (Hogarth et al. 1998), have been mapped in lupus-prone strains.
T14615 5531-5533 IN denotes In
T14617 5534-5537 DT denotes the
T14618 5538-5545 NN denotes context
T14619 5546-5548 IN denotes of
T14620 5549-5552 NN denotes SLE
T14621 5553-5567 NN denotes susceptibility
T14622 5567-5569 , denotes ,
T14623 5569-5572 CD denotes one
T14624 5573-5575 IN denotes of
T14625 5576-5579 DT denotes the
T14627 5580-5584 RBS denotes most
T14628 5585-5597 RB denotes consistently
T14629 5598-5604 VBN denotes mapped
T14630 5605-5612 JJ denotes non-MHC
T14626 5613-5620 NNS denotes regions
T14631 5621-5623 IN denotes of
T14632 5624-5627 DT denotes the
T14634 5628-5633 NN denotes mouse
T14633 5634-5640 NN denotes genome
T14616 5641-5643 VBZ denotes is
T14635 5644-5647 DT denotes the
T14637 5648-5657 JJ denotes telomeric
T14638 5658-5668 NN denotes Chromosome
T14639 5669-5670 CD denotes 1
T14636 5671-5678 NN denotes segment
T14640 5678-5680 , denotes ,
T14641 5680-5685 WRB denotes where
T14643 5686-5693 JJ denotes several
T14645 5694-5701 NN denotes disease
T14644 5702-5706 NNS denotes loci
T14646 5706-5708 , denotes ,
T14647 5708-5718 VBN denotes designated
T14648 5719-5723 NN denotes Sle1
T14649 5724-5725 -LRB- denotes (
T14650 5725-5730 NNP denotes Morel
T14651 5731-5733 FW denotes et
T14652 5734-5737 FW denotes al.
T14653 5738-5742 CD denotes 2001
T14654 5742-5743 -RRB- denotes )
T14655 5743-5745 , denotes ,
T14656 5745-5749 NN denotes Nba2
T14657 5750-5751 -LRB- denotes (
T14658 5751-5756 NNP denotes Drake
T14659 5757-5759 FW denotes et
T14660 5760-5763 FW denotes al.
T14661 5764-5768 CD denotes 1995
T14662 5768-5769 : denotes ;
T14663 5770-5775 NNP denotes Rozzo
T14664 5776-5778 FW denotes et
T14665 5779-5782 FW denotes al.
T14666 5783-5787 CD denotes 1996
T14667 5787-5788 : denotes ;
T14668 5789-5793 NNP denotes Vyse
T14669 5794-5796 FW denotes et
T14670 5797-5800 FW denotes al.
T14671 5801-5805 CD denotes 1997
T14672 5805-5806 -RRB- denotes )
T14673 5806-5808 , denotes ,
T14674 5808-5811 CC denotes and
T14675 5812-5816 NN denotes Bxs3
T14676 5817-5818 -LRB- denotes (
T14677 5818-5825 NNP denotes Hogarth
T14678 5826-5828 FW denotes et
T14679 5829-5832 FW denotes al.
T14680 5833-5837 CD denotes 1998
T14681 5837-5838 -RRB- denotes )
T14682 5838-5840 , denotes ,
T14683 5840-5844 VBP denotes have
T14684 5845-5849 VBN denotes been
T14642 5850-5856 VBN denotes mapped
T14685 5857-5859 IN denotes in
T14686 5860-5865 NN denotes lupus
T14688 5865-5866 HYPH denotes -
T14687 5866-5871 JJ denotes prone
T14689 5872-5879 NNS denotes strains
T14690 5879-5880 . denotes .
T14691 5880-6045 sentence denotes Moreover, this region of mouse Chromosome 1 is orthologous to a region on human Chromosome 1q22–1q25, which has also been linked with human SLE (Moser et al. 1998).
T14692 5881-5889 RB denotes Moreover
T14694 5889-5891 , denotes ,
T14695 5891-5895 DT denotes this
T14696 5896-5902 NN denotes region
T14697 5903-5905 IN denotes of
T14698 5906-5911 NN denotes mouse
T14699 5912-5922 NN denotes Chromosome
T14700 5923-5924 CD denotes 1
T14693 5925-5927 VBZ denotes is
T14701 5928-5939 JJ denotes orthologous
T14702 5940-5942 IN denotes to
T14703 5943-5944 DT denotes a
T14704 5945-5951 NN denotes region
T14705 5952-5954 IN denotes on
T14706 5955-5960 JJ denotes human
T14708 5961-5971 NN denotes Chromosome
T14707 5972-5976 NN denotes 1q22
T14709 5976-5977 SYM denotes –
T14710 5977-5981 NN denotes 1q25
T14711 5981-5983 , denotes ,
T14712 5983-5988 WDT denotes which
T14714 5989-5992 VBZ denotes has
T14715 5993-5997 RB denotes also
T14716 5998-6002 VBN denotes been
T14713 6003-6009 VBN denotes linked
T14717 6010-6014 IN denotes with
T14718 6015-6020 JJ denotes human
T14719 6021-6024 NN denotes SLE
T14720 6025-6026 -LRB- denotes (
T14721 6026-6031 NNP denotes Moser
T14722 6032-6034 FW denotes et
T14723 6035-6038 FW denotes al.
T14724 6039-6043 CD denotes 1998
T14725 6043-6044 -RRB- denotes )
T14726 6044-6045 . denotes .
T14727 6045-6122 sentence denotes The Apcs gene is one of the candidate genes known to lie within this region.
T14728 6046-6049 DT denotes The
T14730 6050-6054 NN denotes Apcs
T14729 6055-6059 NN denotes gene
T14731 6060-6062 VBZ denotes is
T14732 6063-6066 CD denotes one
T14733 6067-6069 IN denotes of
T14734 6070-6073 DT denotes the
T14736 6074-6083 NN denotes candidate
T14735 6084-6089 NNS denotes genes
T14737 6090-6095 VBN denotes known
T14738 6096-6098 TO denotes to
T14739 6099-6102 VB denotes lie
T14740 6103-6109 IN denotes within
T14741 6110-6114 DT denotes this
T14742 6115-6121 NN denotes region
T14743 6121-6122 . denotes .
T14744 6122-6430 sentence denotes The human serum amyloid P component binds avidly to DNA, chromatin, and apoptotic cells in physiological conditions in vitro (Pepys 1974; Pepys and Butler 1987; Butler et al. 1990) and also to exposed chromatin and apoptotic cells in vivo (Hintner et al. 1988; Breathnach et al. 1989; Familian et al. 2001).
T14745 6123-6126 DT denotes The
T14747 6127-6132 JJ denotes human
T14748 6133-6138 NN denotes serum
T14750 6139-6146 NN denotes amyloid
T14749 6147-6148 NN denotes P
T14746 6149-6158 NN denotes component
T14751 6159-6164 VBZ denotes binds
T14752 6165-6171 RB denotes avidly
T14753 6172-6174 IN denotes to
T14754 6175-6178 NN denotes DNA
T14755 6178-6180 , denotes ,
T14756 6180-6189 NN denotes chromatin
T14757 6189-6191 , denotes ,
T14758 6191-6194 CC denotes and
T14759 6195-6204 JJ denotes apoptotic
T14760 6205-6210 NNS denotes cells
T14761 6211-6213 IN denotes in
T14762 6214-6227 JJ denotes physiological
T14763 6228-6238 NNS denotes conditions
T14764 6239-6241 FW denotes in
T14765 6242-6247 FW denotes vitro
T14766 6248-6249 -LRB- denotes (
T14767 6249-6254 NNP denotes Pepys
T14768 6255-6259 CD denotes 1974
T14769 6259-6260 : denotes ;
T14770 6261-6266 NNP denotes Pepys
T14771 6267-6270 CC denotes and
T14772 6271-6277 NNP denotes Butler
T14773 6278-6282 CD denotes 1987
T14774 6282-6283 : denotes ;
T14775 6284-6290 NNP denotes Butler
T14776 6291-6293 FW denotes et
T14777 6294-6297 FW denotes al.
T14778 6298-6302 CD denotes 1990
T14779 6302-6303 -RRB- denotes )
T14780 6304-6307 CC denotes and
T14781 6308-6312 RB denotes also
T14782 6313-6315 IN denotes to
T14783 6316-6323 VBN denotes exposed
T14784 6324-6333 NN denotes chromatin
T14785 6334-6337 CC denotes and
T14786 6338-6347 JJ denotes apoptotic
T14787 6348-6353 NNS denotes cells
T14788 6354-6356 FW denotes in
T14789 6357-6361 FW denotes vivo
T14790 6362-6363 -LRB- denotes (
T14791 6363-6370 NNP denotes Hintner
T14792 6371-6373 FW denotes et
T14793 6374-6377 FW denotes al.
T14794 6378-6382 CD denotes 1988
T14795 6382-6383 : denotes ;
T14796 6384-6394 NNP denotes Breathnach
T14797 6395-6397 FW denotes et
T14798 6398-6401 FW denotes al.
T14799 6402-6406 CD denotes 1989
T14800 6406-6407 : denotes ;
T14801 6408-6416 NNP denotes Familian
T14802 6417-6419 FW denotes et
T14803 6420-6423 FW denotes al.
T14804 6424-6428 CD denotes 2001
T14805 6428-6429 -RRB- denotes )
T14806 6429-6430 . denotes .
T14807 6430-6621 sentence denotes We have previously reported that (129 × C57BL/6).Apcs −/− mice spontaneously produce a wide range of ANAs and develop significant immune complex glomerulonephritis (Bickerstaff et al. 1999).
T14808 6431-6433 PRP denotes We
T14810 6434-6438 VBP denotes have
T14811 6439-6449 RB denotes previously
T14809 6450-6458 VBN denotes reported
T14812 6459-6463 IN denotes that
T14814 6464-6465 -LRB- denotes (
T14815 6465-6468 CD denotes 129
T14817 6469-6470 SYM denotes ×
T14818 6471-6476 NN denotes C57BL
T14819 6476-6477 HYPH denotes /
T14820 6477-6478 CD denotes 6
T14821 6478-6479 -RRB- denotes )
T14822 6479-6480 HYPH denotes .
T14823 6480-6484 NN denotes Apcs
T14824 6485-6486 SYM denotes −
T14825 6486-6487 HYPH denotes /
T14826 6487-6488 SYM denotes −
T14816 6489-6493 NNS denotes mice
T14827 6494-6507 RB denotes spontaneously
T14813 6508-6515 VBP denotes produce
T14828 6516-6517 DT denotes a
T14830 6518-6522 JJ denotes wide
T14829 6523-6528 NN denotes range
T14831 6529-6531 IN denotes of
T14832 6532-6536 NNS denotes ANAs
T14833 6537-6540 CC denotes and
T14834 6541-6548 VB denotes develop
T14835 6549-6560 JJ denotes significant
T14837 6561-6567 JJ denotes immune
T14838 6568-6575 NN denotes complex
T14836 6576-6594 NN denotes glomerulonephritis
T14839 6595-6596 -LRB- denotes (
T14840 6596-6607 NNP denotes Bickerstaff
T14841 6608-6610 FW denotes et
T14842 6611-6614 FW denotes al.
T14843 6615-6619 CD denotes 1999
T14844 6619-6620 -RRB- denotes )
T14845 6620-6621 . denotes .
T14846 6621-6766 sentence denotes On the basis of these observations, it was postulated that Apcs, by altering the clearance of chromatin, contributes to the pathogenesis of SLE.
T14847 6622-6624 IN denotes On
T14849 6625-6628 DT denotes the
T14850 6629-6634 NN denotes basis
T14851 6635-6637 IN denotes of
T14852 6638-6643 DT denotes these
T14853 6644-6656 NNS denotes observations
T14854 6656-6658 , denotes ,
T14855 6658-6660 PRP denotes it
T14856 6661-6664 VBD denotes was
T14848 6665-6675 VBN denotes postulated
T14857 6676-6680 IN denotes that
T14859 6681-6685 NN denotes Apcs
T14860 6685-6687 , denotes ,
T14861 6687-6689 IN denotes by
T14862 6690-6698 VBG denotes altering
T14863 6699-6702 DT denotes the
T14864 6703-6712 NN denotes clearance
T14865 6713-6715 IN denotes of
T14866 6716-6725 NN denotes chromatin
T14867 6725-6727 , denotes ,
T14858 6727-6738 VBZ denotes contributes
T14868 6739-6741 IN denotes to
T14869 6742-6745 DT denotes the
T14870 6746-6758 NN denotes pathogenesis
T14871 6759-6761 IN denotes of
T14872 6762-6765 NN denotes SLE
T14873 6765-6766 . denotes .
T14874 6766-6910 sentence denotes However, in this study we found that only ANA and anti-chromatin Ab levels were significantly increased in the (129 × C57BL/6)F2.Apcs −/− mice.
T14875 6767-6774 RB denotes However
T14877 6774-6776 , denotes ,
T14878 6776-6778 IN denotes in
T14879 6779-6783 DT denotes this
T14880 6784-6789 NN denotes study
T14881 6790-6792 PRP denotes we
T14876 6793-6798 VBD denotes found
T14882 6799-6803 IN denotes that
T14884 6804-6808 RB denotes only
T14886 6809-6812 NN denotes ANA
T14887 6813-6816 CC denotes and
T14888 6817-6831 JJ denotes anti-chromatin
T14889 6832-6834 NN denotes Ab
T14885 6835-6841 NNS denotes levels
T14890 6842-6846 VBD denotes were
T14891 6847-6860 RB denotes significantly
T14883 6861-6870 VBN denotes increased
T14892 6871-6873 IN denotes in
T14893 6874-6877 DT denotes the
T14895 6878-6879 -LRB- denotes (
T14896 6879-6882 CD denotes 129
T14898 6883-6884 SYM denotes ×
T14899 6885-6890 NN denotes C57BL
T14900 6890-6891 HYPH denotes /
T14901 6891-6892 CD denotes 6
T14902 6892-6893 -RRB- denotes )
T14897 6893-6895 NN denotes F2
T14903 6895-6896 HYPH denotes .
T14904 6896-6900 NN denotes Apcs
T14905 6901-6902 SYM denotes −
T14906 6902-6903 HYPH denotes /
T14907 6903-6904 SYM denotes −
T14894 6905-6909 NNS denotes mice
T14908 6909-6910 . denotes .
T14909 6910-7170 sentence denotes A possible explanation for this discrepancy may lie in the fact that the Apcs −/− mice analysed in the original study were generated from a limited number of founders and that this may have caused a nonrandom inheritance of the loci from the parental strains.
T14910 6911-6912 DT denotes A
T14912 6913-6921 JJ denotes possible
T14911 6922-6933 NN denotes explanation
T14914 6934-6937 IN denotes for
T14915 6938-6942 DT denotes this
T14916 6943-6954 NN denotes discrepancy
T14917 6955-6958 MD denotes may
T14913 6959-6962 VB denotes lie
T14918 6963-6965 IN denotes in
T14919 6966-6969 DT denotes the
T14920 6970-6974 NN denotes fact
T14921 6975-6979 IN denotes that
T14923 6980-6983 DT denotes the
T14925 6984-6988 NN denotes Apcs
T14926 6989-6990 SYM denotes −
T14927 6990-6991 HYPH denotes /
T14928 6991-6992 SYM denotes −
T14924 6993-6997 NNS denotes mice
T14929 6998-7006 VBN denotes analysed
T14930 7007-7009 IN denotes in
T14931 7010-7013 DT denotes the
T14933 7014-7022 JJ denotes original
T14932 7023-7028 NN denotes study
T14934 7029-7033 VBD denotes were
T14922 7034-7043 VBN denotes generated
T14935 7044-7048 IN denotes from
T14936 7049-7050 DT denotes a
T14938 7051-7058 JJ denotes limited
T14937 7059-7065 NN denotes number
T14939 7066-7068 IN denotes of
T14940 7069-7077 NNS denotes founders
T14941 7078-7081 CC denotes and
T14942 7082-7086 IN denotes that
T14944 7087-7091 DT denotes this
T14945 7092-7095 MD denotes may
T14946 7096-7100 VB denotes have
T14943 7101-7107 VBN denotes caused
T14947 7108-7109 DT denotes a
T14949 7110-7119 JJ denotes nonrandom
T14948 7120-7131 NN denotes inheritance
T14950 7132-7134 IN denotes of
T14951 7135-7138 DT denotes the
T14952 7139-7143 NNS denotes loci
T14953 7144-7148 IN denotes from
T14954 7149-7152 DT denotes the
T14956 7153-7161 JJ denotes parental
T14955 7162-7169 NNS denotes strains
T14957 7169-7170 . denotes .
T14958 7170-7341 sentence denotes Furthermore, the whole-genome analysis identified the 129 region surrounding the Apcs gene as the main locus contributing to the development of ANA and anti-chromatin Ab.
T14959 7171-7182 RB denotes Furthermore
T14961 7182-7184 , denotes ,
T14962 7184-7187 DT denotes the
T14964 7188-7193 JJ denotes whole
T14966 7193-7194 HYPH denotes -
T14965 7194-7200 NN denotes genome
T14963 7201-7209 NN denotes analysis
T14960 7210-7220 VBD denotes identified
T14967 7221-7224 DT denotes the
T14969 7225-7228 CD denotes 129
T14968 7229-7235 NN denotes region
T14970 7236-7247 VBG denotes surrounding
T14971 7248-7251 DT denotes the
T14973 7252-7256 NN denotes Apcs
T14972 7257-7261 NN denotes gene
T14974 7262-7264 IN denotes as
T14975 7265-7268 DT denotes the
T14977 7269-7273 JJ denotes main
T14976 7274-7279 NN denotes locus
T14978 7280-7292 VBG denotes contributing
T14979 7293-7295 IN denotes to
T14980 7296-7299 DT denotes the
T14981 7300-7311 NN denotes development
T14982 7312-7314 IN denotes of
T14983 7315-7318 NN denotes ANA
T14984 7319-7322 CC denotes and
T14985 7323-7337 JJ denotes anti-chromatin
T14986 7338-7340 NN denotes Ab
T14987 7340-7341 . denotes .
T14988 7341-7583 sentence denotes In agreement with this, when we carried out a selective comparison between the (129 × C57BL/6)F2.Apcs −/− mice and Chromosome 1 genetically matched controls, we failed to detect any significant difference in the levels of these two auto-Abs.
T14989 7342-7344 IN denotes In
T14991 7345-7354 NN denotes agreement
T14992 7355-7359 IN denotes with
T14993 7360-7364 DT denotes this
T14994 7364-7366 , denotes ,
T14995 7366-7370 WRB denotes when
T14997 7371-7373 PRP denotes we
T14996 7374-7381 VBD denotes carried
T14998 7382-7385 RP denotes out
T14999 7386-7387 DT denotes a
T15001 7388-7397 JJ denotes selective
T15000 7398-7408 NN denotes comparison
T15002 7409-7416 IN denotes between
T15003 7417-7420 DT denotes the
T15005 7421-7422 -LRB- denotes (
T15006 7422-7425 CD denotes 129
T15008 7426-7427 SYM denotes ×
T15009 7428-7433 NN denotes C57BL
T15010 7433-7434 HYPH denotes /
T15011 7434-7435 CD denotes 6
T15012 7435-7436 -RRB- denotes )
T15007 7436-7438 NN denotes F2
T15013 7438-7439 HYPH denotes .
T15014 7439-7443 NN denotes Apcs
T15015 7444-7445 SYM denotes −
T15016 7445-7446 HYPH denotes /
T15017 7446-7447 SYM denotes −
T15004 7448-7452 NNS denotes mice
T15018 7453-7456 CC denotes and
T15019 7457-7467 NN denotes Chromosome
T15021 7468-7469 CD denotes 1
T15022 7470-7481 RB denotes genetically
T15023 7482-7489 VBN denotes matched
T15020 7490-7498 NNS denotes controls
T15024 7498-7500 , denotes ,
T15025 7500-7502 PRP denotes we
T14990 7503-7509 VBD denotes failed
T15026 7510-7512 TO denotes to
T15027 7513-7519 VB denotes detect
T15028 7520-7523 DT denotes any
T15030 7524-7535 JJ denotes significant
T15029 7536-7546 NN denotes difference
T15031 7547-7549 IN denotes in
T15032 7550-7553 DT denotes the
T15033 7554-7560 NNS denotes levels
T15034 7561-7563 IN denotes of
T15035 7564-7569 DT denotes these
T15037 7570-7573 CD denotes two
T15036 7574-7582 NNS denotes auto-Abs
T15038 7582-7583 . denotes .
T15039 7583-7813 sentence denotes These findings, taken together, indicated that the phenotype associated with Apcs deficiency was caused by the presence of unaltered 129 genes from the telomeric region of Chromosome 1 operating in the C57BL/6 genomic background.
T15040 7584-7589 DT denotes These
T15041 7590-7598 NNS denotes findings
T15043 7598-7600 , denotes ,
T15044 7600-7605 VBN denotes taken
T15045 7606-7614 RB denotes together
T15046 7614-7616 , denotes ,
T15042 7616-7625 VBD denotes indicated
T15047 7626-7630 IN denotes that
T15049 7631-7634 DT denotes the
T15050 7635-7644 NN denotes phenotype
T15051 7645-7655 VBN denotes associated
T15052 7656-7660 IN denotes with
T15053 7661-7665 NN denotes Apcs
T15054 7666-7676 NN denotes deficiency
T15055 7677-7680 VBD denotes was
T15048 7681-7687 VBN denotes caused
T15056 7688-7690 IN denotes by
T15057 7691-7694 DT denotes the
T15058 7695-7703 NN denotes presence
T15059 7704-7706 IN denotes of
T15060 7707-7716 JJ denotes unaltered
T15062 7717-7720 CD denotes 129
T15061 7721-7726 NNS denotes genes
T15063 7727-7731 IN denotes from
T15064 7732-7735 DT denotes the
T15066 7736-7745 JJ denotes telomeric
T15065 7746-7752 NN denotes region
T15067 7753-7755 IN denotes of
T15068 7756-7766 NN denotes Chromosome
T15069 7767-7768 CD denotes 1
T15070 7769-7778 VBG denotes operating
T15071 7779-7781 IN denotes in
T15072 7782-7785 DT denotes the
T15074 7786-7791 NN denotes C57BL
T15075 7791-7792 HYPH denotes /
T15076 7792-7793 CD denotes 6
T15077 7794-7801 JJ denotes genomic
T15073 7802-7812 NN denotes background
T15078 7812-7813 . denotes .
T15079 7813-7928 sentence denotes Strong supportive evidence for this was provided by the analysis of the C57BL/6 mice congenic for this 129 region.
T15080 7814-7820 JJ denotes Strong
T15082 7821-7831 JJ denotes supportive
T15081 7832-7840 NN denotes evidence
T15084 7841-7844 IN denotes for
T15085 7845-7849 DT denotes this
T15086 7850-7853 VBD denotes was
T15083 7854-7862 VBN denotes provided
T15087 7863-7865 IN denotes by
T15088 7866-7869 DT denotes the
T15089 7870-7878 NN denotes analysis
T15090 7879-7881 IN denotes of
T15091 7882-7885 DT denotes the
T15093 7886-7891 NN denotes C57BL
T15094 7891-7892 HYPH denotes /
T15095 7892-7893 CD denotes 6
T15092 7894-7898 NNS denotes mice
T15096 7899-7907 JJ denotes congenic
T15097 7908-7911 IN denotes for
T15098 7912-7916 DT denotes this
T15100 7917-7920 CD denotes 129
T15099 7921-7927 NN denotes region
T15101 7927-7928 . denotes .
T15102 7928-8104 sentence denotes The generation and analysis of congenic strains have successfully been used to dissect the contribution of individual susceptibility alleles to a multigenic trait such as SLE.
T15103 7929-7932 DT denotes The
T15104 7933-7943 NN denotes generation
T15106 7944-7947 CC denotes and
T15107 7948-7956 NN denotes analysis
T15108 7957-7959 IN denotes of
T15109 7960-7968 JJ denotes congenic
T15110 7969-7976 NNS denotes strains
T15111 7977-7981 VBP denotes have
T15112 7982-7994 RB denotes successfully
T15113 7995-7999 VBN denotes been
T15105 8000-8004 VBN denotes used
T15114 8005-8007 TO denotes to
T15115 8008-8015 VB denotes dissect
T15116 8016-8019 DT denotes the
T15117 8020-8032 NN denotes contribution
T15118 8033-8035 IN denotes of
T15119 8036-8046 JJ denotes individual
T15121 8047-8061 NN denotes susceptibility
T15120 8062-8069 NNS denotes alleles
T15122 8070-8072 IN denotes to
T15123 8073-8074 DT denotes a
T15125 8075-8085 JJ denotes multigenic
T15124 8086-8091 NN denotes trait
T15126 8092-8096 JJ denotes such
T15127 8097-8099 IN denotes as
T15128 8100-8103 NN denotes SLE
T15129 8103-8104 . denotes .
T15130 8104-8247 sentence denotes We adopted the same strategy to investigate the relative contribution of the 129 Chromosome 1 segment and the Apcs gene to each disease trait.
T15131 8105-8107 PRP denotes We
T15132 8108-8115 VBD denotes adopted
T15133 8116-8119 DT denotes the
T15135 8120-8124 JJ denotes same
T15134 8125-8133 NN denotes strategy
T15136 8134-8136 TO denotes to
T15137 8137-8148 VB denotes investigate
T15138 8149-8152 DT denotes the
T15140 8153-8161 JJ denotes relative
T15139 8162-8174 NN denotes contribution
T15141 8175-8177 IN denotes of
T15142 8178-8181 DT denotes the
T15144 8182-8185 CD denotes 129
T15145 8186-8196 NN denotes Chromosome
T15146 8197-8198 CD denotes 1
T15143 8199-8206 NN denotes segment
T15147 8207-8210 CC denotes and
T15148 8211-8214 DT denotes the
T15150 8215-8219 NN denotes Apcs
T15149 8220-8224 NN denotes gene
T15151 8225-8227 IN denotes to
T15152 8228-8232 DT denotes each
T15154 8233-8240 NN denotes disease
T15153 8241-8246 NN denotes trait
T15155 8246-8247 . denotes .
T15156 8247-8537 sentence denotes Using this approach, we demonstrated that the 129 interval on distal Chromosome 1, when transferred onto the C57BL/6 genome, a combination commonly created by backcrossing onto C57BL/6 a mutated gene located in that chromosomal region, was sufficient to mediate the production of auto-Abs.
T15157 8248-8253 VBG denotes Using
T15159 8254-8258 DT denotes this
T15160 8259-8267 NN denotes approach
T15161 8267-8269 , denotes ,
T15162 8269-8271 PRP denotes we
T15158 8272-8284 VBD denotes demonstrated
T15163 8285-8289 IN denotes that
T15165 8290-8293 DT denotes the
T15167 8294-8297 CD denotes 129
T15166 8298-8306 NN denotes interval
T15168 8307-8309 IN denotes on
T15169 8310-8316 JJ denotes distal
T15170 8317-8327 NN denotes Chromosome
T15171 8328-8329 CD denotes 1
T15172 8329-8331 , denotes ,
T15173 8331-8335 WRB denotes when
T15174 8336-8347 VBN denotes transferred
T15175 8348-8352 IN denotes onto
T15176 8353-8356 DT denotes the
T15178 8357-8362 NN denotes C57BL
T15179 8362-8363 HYPH denotes /
T15180 8363-8364 CD denotes 6
T15177 8365-8371 NN denotes genome
T15181 8371-8373 , denotes ,
T15182 8373-8374 DT denotes a
T15183 8375-8386 NN denotes combination
T15184 8387-8395 RB denotes commonly
T15185 8396-8403 VBN denotes created
T15186 8404-8406 IN denotes by
T15187 8407-8419 VBG denotes backcrossing
T15188 8420-8424 IN denotes onto
T15189 8425-8430 NN denotes C57BL
T15190 8430-8431 HYPH denotes /
T15191 8431-8432 CD denotes 6
T15192 8433-8434 DT denotes a
T15194 8435-8442 VBN denotes mutated
T15193 8443-8447 NN denotes gene
T15195 8448-8455 VBN denotes located
T15196 8456-8458 IN denotes in
T15197 8459-8463 DT denotes that
T15199 8464-8475 JJ denotes chromosomal
T15198 8476-8482 NN denotes region
T15200 8482-8484 , denotes ,
T15164 8484-8487 VBD denotes was
T15201 8488-8498 JJ denotes sufficient
T15202 8499-8501 TO denotes to
T15203 8502-8509 VB denotes mediate
T15204 8510-8513 DT denotes the
T15205 8514-8524 NN denotes production
T15206 8525-8527 IN denotes of
T15207 8528-8536 NNS denotes auto-Abs
T15208 8536-8537 . denotes .
T15209 8537-8889 sentence denotes In this context, it is of note that several strains of mice with targeted mutations of genes encoded in this region have been reported to express a lupus-like illness, including mice lacking FcγRIIB (Bolland and Ravetch 2000), complement receptors (CR1/2) (Prodeus et al. 1998; Wu et al. 2002), and decay-accelerating factor (CD55) (Miwa et al. 2002).
T15210 8538-8540 IN denotes In
T15212 8541-8545 DT denotes this
T15213 8546-8553 NN denotes context
T15214 8553-8555 , denotes ,
T15215 8555-8557 PRP denotes it
T15211 8558-8560 VBZ denotes is
T15216 8561-8563 IN denotes of
T15217 8564-8568 NN denotes note
T15218 8569-8573 IN denotes that
T15220 8574-8581 JJ denotes several
T15221 8582-8589 NNS denotes strains
T15222 8590-8592 IN denotes of
T15223 8593-8597 NNS denotes mice
T15224 8598-8602 IN denotes with
T15225 8603-8611 VBN denotes targeted
T15226 8612-8621 NNS denotes mutations
T15227 8622-8624 IN denotes of
T15228 8625-8630 NNS denotes genes
T15229 8631-8638 VBN denotes encoded
T15230 8639-8641 IN denotes in
T15231 8642-8646 DT denotes this
T15232 8647-8653 NN denotes region
T15233 8654-8658 VBP denotes have
T15234 8659-8663 VBN denotes been
T15219 8664-8672 VBN denotes reported
T15235 8673-8675 TO denotes to
T15236 8676-8683 VB denotes express
T15237 8684-8685 DT denotes a
T15239 8686-8691 NN denotes lupus
T15241 8691-8692 HYPH denotes -
T15240 8692-8696 JJ denotes like
T15238 8697-8704 NN denotes illness
T15242 8704-8706 , denotes ,
T15243 8706-8715 VBG denotes including
T15244 8716-8720 NNS denotes mice
T15245 8721-8728 VBG denotes lacking
T15246 8729-8736 NN denotes FcγRIIB
T15247 8737-8738 -LRB- denotes (
T15248 8738-8745 NNP denotes Bolland
T15249 8746-8749 CC denotes and
T15250 8750-8757 NNP denotes Ravetch
T15251 8758-8762 CD denotes 2000
T15252 8762-8763 -RRB- denotes )
T15253 8763-8765 , denotes ,
T15254 8765-8775 NN denotes complement
T15255 8776-8785 NNS denotes receptors
T15256 8786-8787 -LRB- denotes (
T15257 8787-8790 NN denotes CR1
T15258 8790-8791 HYPH denotes /
T15259 8791-8792 CD denotes 2
T15260 8792-8793 -RRB- denotes )
T15261 8794-8795 -LRB- denotes (
T15262 8795-8802 NNP denotes Prodeus
T15263 8803-8805 FW denotes et
T15264 8806-8809 FW denotes al.
T15265 8810-8814 CD denotes 1998
T15266 8814-8815 : denotes ;
T15267 8816-8818 NNP denotes Wu
T15268 8819-8821 FW denotes et
T15269 8822-8825 FW denotes al.
T15270 8826-8830 CD denotes 2002
T15271 8830-8831 -RRB- denotes )
T15272 8831-8833 , denotes ,
T15273 8833-8836 CC denotes and
T15274 8837-8842 NN denotes decay
T15276 8842-8843 HYPH denotes -
T15275 8843-8855 VBG denotes accelerating
T15277 8856-8862 NN denotes factor
T15278 8863-8864 -LRB- denotes (
T15279 8864-8868 NN denotes CD55
T15280 8868-8869 -RRB- denotes )
T15281 8870-8871 -LRB- denotes (
T15282 8871-8875 NNP denotes Miwa
T15283 8876-8878 FW denotes et
T15284 8879-8882 FW denotes al.
T15285 8883-8887 CD denotes 2002
T15286 8887-8888 -RRB- denotes )
T15287 8888-8889 . denotes .
T15288 8889-9086 sentence denotes In each case, the autoimmune phenotype was described in mice in which the null mutation was generated in 129 embryonic stem cells and then backcrossed to the C57BL/6 or another genetic background.
T15289 8890-8892 IN denotes In
T15291 8893-8897 DT denotes each
T15292 8898-8902 NN denotes case
T15293 8902-8904 , denotes ,
T15294 8904-8907 DT denotes the
T15296 8908-8918 JJ denotes autoimmune
T15295 8919-8928 NN denotes phenotype
T15297 8929-8932 VBD denotes was
T15290 8933-8942 VBN denotes described
T15298 8943-8945 IN denotes in
T15299 8946-8950 NNS denotes mice
T15300 8951-8953 IN denotes in
T15302 8954-8959 WDT denotes which
T15303 8960-8963 DT denotes the
T15305 8964-8968 JJ denotes null
T15304 8969-8977 NN denotes mutation
T15306 8978-8981 VBD denotes was
T15301 8982-8991 VBN denotes generated
T15307 8992-8994 IN denotes in
T15308 8995-8998 CD denotes 129
T15310 8999-9008 JJ denotes embryonic
T15311 9009-9013 NN denotes stem
T15309 9014-9019 NNS denotes cells
T15312 9020-9023 CC denotes and
T15313 9024-9028 RB denotes then
T15314 9029-9040 VBD denotes backcrossed
T15315 9041-9043 IN denotes to
T15316 9044-9047 DT denotes the
T15317 9048-9053 NN denotes C57BL
T15318 9053-9054 HYPH denotes /
T15319 9054-9055 CD denotes 6
T15320 9056-9058 CC denotes or
T15321 9059-9066 DT denotes another
T15323 9067-9074 JJ denotes genetic
T15322 9075-9085 NN denotes background
T15324 9085-9086 . denotes .
T15325 9086-9234 sentence denotes Thus, in view of our findings, one may postulate that in each of these murine models of SLE, the effects of the targeted null gene were irrelevant.
T15326 9087-9091 RB denotes Thus
T15328 9091-9093 , denotes ,
T15329 9093-9095 IN denotes in
T15330 9096-9100 NN denotes view
T15331 9101-9103 IN denotes of
T15332 9104-9107 PRP$ denotes our
T15333 9108-9116 NNS denotes findings
T15334 9116-9118 , denotes ,
T15335 9118-9121 PRP denotes one
T15336 9122-9125 MD denotes may
T15327 9126-9135 VB denotes postulate
T15337 9136-9140 IN denotes that
T15339 9141-9143 IN denotes in
T15340 9144-9148 DT denotes each
T15341 9149-9151 IN denotes of
T15342 9152-9157 DT denotes these
T15344 9158-9164 JJ denotes murine
T15343 9165-9171 NNS denotes models
T15345 9172-9174 IN denotes of
T15346 9175-9178 NN denotes SLE
T15347 9178-9180 , denotes ,
T15348 9180-9183 DT denotes the
T15349 9184-9191 NNS denotes effects
T15350 9192-9194 IN denotes of
T15351 9195-9198 DT denotes the
T15353 9199-9207 VBN denotes targeted
T15354 9208-9212 JJ denotes null
T15352 9213-9217 NN denotes gene
T15338 9218-9222 VBD denotes were
T15355 9223-9233 JJ denotes irrelevant
T15356 9233-9234 . denotes .
T15357 9234-9416 sentence denotes Similar conclusions may apply to other gene-targeted animals carrying mutations of genes mapped in the 129-derived susceptibility allele on Chromosome 7 (O'Keefe et al. 1996, 1999).
T15358 9235-9242 JJ denotes Similar
T15359 9243-9254 NNS denotes conclusions
T15361 9255-9258 MD denotes may
T15360 9259-9264 VB denotes apply
T15362 9265-9267 IN denotes to
T15363 9268-9273 JJ denotes other
T15365 9274-9278 NN denotes gene
T15367 9278-9279 HYPH denotes -
T15366 9279-9287 VBN denotes targeted
T15364 9288-9295 NNS denotes animals
T15368 9296-9304 VBG denotes carrying
T15369 9305-9314 NNS denotes mutations
T15370 9315-9317 IN denotes of
T15371 9318-9323 NNS denotes genes
T15372 9324-9330 VBN denotes mapped
T15373 9331-9333 IN denotes in
T15374 9334-9337 DT denotes the
T15376 9338-9341 CD denotes 129
T15378 9341-9342 HYPH denotes -
T15377 9342-9349 VBN denotes derived
T15379 9350-9364 NN denotes susceptibility
T15375 9365-9371 NN denotes allele
T15380 9372-9374 IN denotes on
T15381 9375-9385 NN denotes Chromosome
T15382 9386-9387 CD denotes 7
T15383 9388-9389 -LRB- denotes (
T15384 9389-9396 NNP denotes O'Keefe
T15385 9397-9399 FW denotes et
T15386 9400-9403 FW denotes al.
T15387 9404-9408 CD denotes 1996
T15388 9408-9410 , denotes ,
T15389 9410-9414 CD denotes 1999
T15390 9414-9415 -RRB- denotes )
T15391 9415-9416 . denotes .
T15392 9416-9520 sentence denotes The expression of anti-nuclear autoimmunity was identical comparing the congenic with the Apcs−/− mice.
T15393 9417-9420 DT denotes The
T15394 9421-9431 NN denotes expression
T15396 9432-9434 IN denotes of
T15397 9435-9447 JJ denotes anti-nuclear
T15398 9448-9460 NN denotes autoimmunity
T15395 9461-9464 VBD denotes was
T15399 9465-9474 JJ denotes identical
T15400 9475-9484 VBG denotes comparing
T15401 9485-9488 DT denotes the
T15402 9489-9497 JJ denotes congenic
T15403 9498-9502 IN denotes with
T15404 9503-9506 DT denotes the
T15405 9507-9511 NN denotes Apcs
T15406 9511-9512 SYM denotes −
T15407 9512-9513 HYPH denotes /
T15408 9513-9514 SYM denotes −
T15409 9515-9519 NNS denotes mice
T15410 9519-9520 . denotes .
T15411 9520-9696 sentence denotes The only difference in phenotype between these mice was in the expression of glomerulonephritis, which was more pronounced in the Apcs−/− mice compared with the congenic mice.
T15412 9521-9524 DT denotes The
T15414 9525-9529 JJ denotes only
T15413 9530-9540 NN denotes difference
T15416 9541-9543 IN denotes in
T15417 9544-9553 NN denotes phenotype
T15418 9554-9561 IN denotes between
T15419 9562-9567 DT denotes these
T15420 9568-9572 NNS denotes mice
T15415 9573-9576 VBD denotes was
T15421 9577-9579 IN denotes in
T15422 9580-9583 DT denotes the
T15423 9584-9594 NN denotes expression
T15424 9595-9597 IN denotes of
T15425 9598-9616 NN denotes glomerulonephritis
T15426 9616-9618 , denotes ,
T15427 9618-9623 WDT denotes which
T15428 9624-9627 VBD denotes was
T15429 9628-9632 RBR denotes more
T15430 9633-9643 JJ denotes pronounced
T15431 9644-9646 IN denotes in
T15432 9647-9650 DT denotes the
T15434 9651-9655 NN denotes Apcs
T15435 9655-9656 SYM denotes −
T15436 9656-9657 HYPH denotes /
T15437 9657-9658 SYM denotes −
T15433 9659-9663 NNS denotes mice
T15438 9664-9672 VBN denotes compared
T15439 9673-9677 IN denotes with
T15440 9678-9681 DT denotes the
T15442 9682-9690 JJ denotes congenic
T15441 9691-9695 NNS denotes mice
T15443 9695-9696 . denotes .
T15444 9696-9922 sentence denotes Although these findings demonstrate that Apcs is not implicated in the processing of autoantigens, as it had previously been suggested, they indicate that Apcs might still play an important protective role in lupus nephritis.
T15445 9697-9705 IN denotes Although
T15447 9706-9711 DT denotes these
T15448 9712-9720 NNS denotes findings
T15446 9721-9732 VBP denotes demonstrate
T15450 9733-9737 IN denotes that
T15452 9738-9742 NN denotes Apcs
T15453 9743-9745 VBZ denotes is
T15454 9746-9749 RB denotes not
T15451 9750-9760 VBN denotes implicated
T15455 9761-9763 IN denotes in
T15456 9764-9767 DT denotes the
T15457 9768-9778 NN denotes processing
T15458 9779-9781 IN denotes of
T15459 9782-9794 NNS denotes autoantigens
T15460 9794-9796 , denotes ,
T15461 9796-9798 IN denotes as
T15463 9799-9801 PRP denotes it
T15464 9802-9805 VBD denotes had
T15465 9806-9816 RB denotes previously
T15466 9817-9821 VBN denotes been
T15462 9822-9831 VBN denotes suggested
T15467 9831-9833 , denotes ,
T15468 9833-9837 PRP denotes they
T15449 9838-9846 VBP denotes indicate
T15469 9847-9851 IN denotes that
T15471 9852-9856 NN denotes Apcs
T15472 9857-9862 MD denotes might
T15473 9863-9868 RB denotes still
T15470 9869-9873 VB denotes play
T15474 9874-9876 DT denotes an
T15476 9877-9886 JJ denotes important
T15477 9887-9897 JJ denotes protective
T15475 9898-9902 NN denotes role
T15478 9903-9905 IN denotes in
T15479 9906-9911 NN denotes lupus
T15480 9912-9921 NN denotes nephritis
T15481 9921-9922 . denotes .
T15482 9922-10215 sentence denotes In support of this, the expression of the human C-reactive protein, an acute-phase protein closely related to Apcs, has been shown to delay the onset and severity of lupus nephritis in the NZB/W strain by preventing the deposition of immune complexes in the renal cortex (Szalai et al. 2003).
T15483 9923-9925 IN denotes In
T15485 9926-9933 NN denotes support
T15486 9934-9936 IN denotes of
T15487 9937-9941 DT denotes this
T15488 9941-9943 , denotes ,
T15489 9943-9946 DT denotes the
T15490 9947-9957 NN denotes expression
T15491 9958-9960 IN denotes of
T15492 9961-9964 DT denotes the
T15494 9965-9970 JJ denotes human
T15495 9971-9972 NN denotes C
T15497 9972-9973 HYPH denotes -
T15496 9973-9981 JJ denotes reactive
T15493 9982-9989 NN denotes protein
T15498 9989-9991 , denotes ,
T15499 9991-9993 DT denotes an
T15501 9994-9999 JJ denotes acute
T15503 9999-10000 HYPH denotes -
T15502 10000-10005 NN denotes phase
T15500 10006-10013 NN denotes protein
T15504 10014-10021 RB denotes closely
T15505 10022-10029 JJ denotes related
T15506 10030-10032 IN denotes to
T15507 10033-10037 NN denotes Apcs
T15508 10037-10039 , denotes ,
T15509 10039-10042 VBZ denotes has
T15510 10043-10047 VBN denotes been
T15484 10048-10053 VBN denotes shown
T15511 10054-10056 TO denotes to
T15512 10057-10062 VB denotes delay
T15513 10063-10066 DT denotes the
T15514 10067-10072 NN denotes onset
T15515 10073-10076 CC denotes and
T15516 10077-10085 NN denotes severity
T15517 10086-10088 IN denotes of
T15518 10089-10094 NN denotes lupus
T15519 10095-10104 NN denotes nephritis
T15520 10105-10107 IN denotes in
T15521 10108-10111 DT denotes the
T15523 10112-10115 NN denotes NZB
T15525 10115-10116 HYPH denotes /
T15524 10116-10117 NN denotes W
T15522 10118-10124 NN denotes strain
T15526 10125-10127 IN denotes by
T15527 10128-10138 VBG denotes preventing
T15528 10139-10142 DT denotes the
T15529 10143-10153 NN denotes deposition
T15530 10154-10156 IN denotes of
T15531 10157-10163 JJ denotes immune
T15532 10164-10173 NNS denotes complexes
T15533 10174-10176 IN denotes in
T15534 10177-10180 DT denotes the
T15536 10181-10186 JJ denotes renal
T15535 10187-10193 NN denotes cortex
T15537 10194-10195 -LRB- denotes (
T15538 10195-10201 NNP denotes Szalai
T15539 10202-10204 FW denotes et
T15540 10205-10208 FW denotes al.
T15541 10209-10213 CD denotes 2003
T15542 10213-10214 -RRB- denotes )
T15543 10214-10215 . denotes .
T15544 10215-10381 sentence denotes Consistent with this, a polymorphism associated with reduced basal level of C-reactive protein has been reported to be linked to SLE in humans (Russell et al. 2004).
T15545 10216-10226 JJ denotes Consistent
T15547 10227-10231 IN denotes with
T15548 10232-10236 DT denotes this
T15549 10236-10238 , denotes ,
T15550 10238-10239 DT denotes a
T15551 10240-10252 NN denotes polymorphism
T15552 10253-10263 VBN denotes associated
T15553 10264-10268 IN denotes with
T15554 10269-10276 VBN denotes reduced
T15556 10277-10282 JJ denotes basal
T15555 10283-10288 NN denotes level
T15557 10289-10291 IN denotes of
T15558 10292-10293 NN denotes C
T15560 10293-10294 HYPH denotes -
T15559 10294-10302 JJ denotes reactive
T15561 10303-10310 NN denotes protein
T15562 10311-10314 VBZ denotes has
T15563 10315-10319 VBN denotes been
T15546 10320-10328 VBN denotes reported
T15564 10329-10331 TO denotes to
T15566 10332-10334 VB denotes be
T15565 10335-10341 VBN denotes linked
T15567 10342-10344 IN denotes to
T15568 10345-10348 NN denotes SLE
T15569 10349-10351 IN denotes in
T15570 10352-10358 NNS denotes humans
T15571 10359-10360 -LRB- denotes (
T15572 10360-10367 NNP denotes Russell
T15573 10368-10370 FW denotes et
T15574 10371-10374 FW denotes al.
T15575 10375-10379 CD denotes 2004
T15576 10379-10380 -RRB- denotes )
T15577 10380-10381 . denotes .
T15578 10381-10703 sentence denotes However, as the congenic mice and the Apcs−/− mice carried similar but not identical 129 regions on Chromosome 1, an alternative explanation for our findings may still lay in the numerous and complex synergistic and counteractive interactions between 129 and C57BL/6 genes involved in self-tolerance and end organ damage.
T15579 10382-10389 RB denotes However
T15581 10389-10391 , denotes ,
T15582 10391-10393 IN denotes as
T15584 10394-10397 DT denotes the
T15586 10398-10406 JJ denotes congenic
T15585 10407-10411 NNS denotes mice
T15587 10412-10415 CC denotes and
T15588 10416-10419 DT denotes the
T15590 10420-10424 NN denotes Apcs
T15591 10424-10425 SYM denotes −
T15592 10425-10426 HYPH denotes /
T15593 10426-10427 SYM denotes −
T15589 10428-10432 NNS denotes mice
T15583 10433-10440 VBN denotes carried
T15594 10441-10448 JJ denotes similar
T15596 10449-10452 CC denotes but
T15597 10453-10456 RB denotes not
T15598 10457-10466 JJ denotes identical
T15599 10467-10470 CD denotes 129
T15595 10471-10478 NNS denotes regions
T15600 10479-10481 IN denotes on
T15601 10482-10492 NN denotes Chromosome
T15602 10493-10494 CD denotes 1
T15603 10494-10496 , denotes ,
T15604 10496-10498 DT denotes an
T15606 10499-10510 JJ denotes alternative
T15605 10511-10522 NN denotes explanation
T15607 10523-10526 IN denotes for
T15608 10527-10530 PRP$ denotes our
T15609 10531-10539 NNS denotes findings
T15610 10540-10543 MD denotes may
T15611 10544-10549 RB denotes still
T15580 10550-10553 VB denotes lay
T15612 10554-10556 IN denotes in
T15613 10557-10560 DT denotes the
T15615 10561-10569 JJ denotes numerous
T15616 10570-10573 CC denotes and
T15617 10574-10581 JJ denotes complex
T15618 10582-10593 JJ denotes synergistic
T15619 10594-10597 CC denotes and
T15620 10598-10611 JJ denotes counteractive
T15614 10612-10624 NNS denotes interactions
T15621 10625-10632 IN denotes between
T15622 10633-10636 CD denotes 129
T15624 10637-10640 CC denotes and
T15625 10641-10646 NN denotes C57BL
T15626 10646-10647 HYPH denotes /
T15627 10647-10648 CD denotes 6
T15623 10649-10654 NNS denotes genes
T15628 10655-10663 VBN denotes involved
T15629 10664-10666 IN denotes in
T15630 10667-10671 NN denotes self
T15632 10671-10672 HYPH denotes -
T15631 10672-10681 NN denotes tolerance
T15633 10682-10685 CC denotes and
T15634 10686-10689 NN denotes end
T15636 10690-10695 NN denotes organ
T15635 10696-10702 NN denotes damage
T15637 10702-10703 . denotes .
T15638 10703-10967 sentence denotes Thus, whilst the lack of lupus nephritis in the congenic mice is consistent with the need for multiple susceptibility genes for the full expression of lupus, further studies will be required to fully elucidate the role of Apcs in the pathogenesis of renal damage.
T15639 10704-10708 RB denotes Thus
T15641 10708-10710 , denotes ,
T15642 10710-10716 IN denotes whilst
T15644 10717-10720 DT denotes the
T15645 10721-10725 NN denotes lack
T15646 10726-10728 IN denotes of
T15647 10729-10734 NN denotes lupus
T15648 10735-10744 NN denotes nephritis
T15649 10745-10747 IN denotes in
T15650 10748-10751 DT denotes the
T15652 10752-10760 JJ denotes congenic
T15651 10761-10765 NNS denotes mice
T15643 10766-10768 VBZ denotes is
T15653 10769-10779 JJ denotes consistent
T15654 10780-10784 IN denotes with
T15655 10785-10788 DT denotes the
T15656 10789-10793 NN denotes need
T15657 10794-10797 IN denotes for
T15658 10798-10806 JJ denotes multiple
T15660 10807-10821 NN denotes susceptibility
T15659 10822-10827 NNS denotes genes
T15661 10828-10831 IN denotes for
T15662 10832-10835 DT denotes the
T15664 10836-10840 JJ denotes full
T15663 10841-10851 NN denotes expression
T15665 10852-10854 IN denotes of
T15666 10855-10860 NN denotes lupus
T15667 10860-10862 , denotes ,
T15668 10862-10869 JJ denotes further
T15669 10870-10877 NNS denotes studies
T15670 10878-10882 MD denotes will
T15671 10883-10885 VB denotes be
T15640 10886-10894 VBN denotes required
T15672 10895-10897 TO denotes to
T15674 10898-10903 RB denotes fully
T15673 10904-10913 VB denotes elucidate
T15675 10914-10917 DT denotes the
T15676 10918-10922 NN denotes role
T15677 10923-10925 IN denotes of
T15678 10926-10930 NN denotes Apcs
T15679 10931-10933 IN denotes in
T15680 10934-10937 DT denotes the
T15681 10938-10950 NN denotes pathogenesis
T15682 10951-10953 IN denotes of
T15683 10954-10959 JJ denotes renal
T15684 10960-10966 NN denotes damage
T15685 10966-10967 . denotes .
T15686 10967-11259 sentence denotes In summary, our findings demonstrate the impact of epistatic interactions between 129 and C57BL/6 genomes on the development of SLE and illustrate how these background gene effects may lead to incorrect interpretations when analysing the autoimmune phenotype of specific genetic disruptions.
T15687 10968-10970 IN denotes In
T15689 10971-10978 NN denotes summary
T15690 10978-10980 , denotes ,
T15691 10980-10983 PRP$ denotes our
T15692 10984-10992 NNS denotes findings
T15688 10993-11004 VBP denotes demonstrate
T15693 11005-11008 DT denotes the
T15694 11009-11015 NN denotes impact
T15695 11016-11018 IN denotes of
T15696 11019-11028 JJ denotes epistatic
T15697 11029-11041 NNS denotes interactions
T15698 11042-11049 IN denotes between
T15699 11050-11053 CD denotes 129
T15701 11054-11057 CC denotes and
T15700 11058-11063 NN denotes C57BL
T15703 11063-11064 HYPH denotes /
T15704 11064-11065 CD denotes 6
T15702 11066-11073 NNS denotes genomes
T15705 11074-11076 IN denotes on
T15706 11077-11080 DT denotes the
T15707 11081-11092 NN denotes development
T15708 11093-11095 IN denotes of
T15709 11096-11099 NN denotes SLE
T15710 11100-11103 CC denotes and
T15711 11104-11114 VBP denotes illustrate
T15712 11115-11118 WRB denotes how
T15714 11119-11124 DT denotes these
T15716 11125-11135 NN denotes background
T15717 11136-11140 NN denotes gene
T15715 11141-11148 NNS denotes effects
T15718 11149-11152 MD denotes may
T15713 11153-11157 VB denotes lead
T15719 11158-11160 IN denotes to
T15720 11161-11170 JJ denotes incorrect
T15721 11171-11186 NNS denotes interpretations
T15722 11187-11191 WRB denotes when
T15723 11192-11201 VBG denotes analysing
T15724 11202-11205 DT denotes the
T15726 11206-11216 JJ denotes autoimmune
T15725 11217-11226 NN denotes phenotype
T15727 11227-11229 IN denotes of
T15728 11230-11238 JJ denotes specific
T15730 11239-11246 JJ denotes genetic
T15729 11247-11258 NNS denotes disruptions
T15731 11258-11259 . denotes .
R3040 T13555 T13556 expl There,is
R3042 T13557 T13558 amod accumulating,evidence
R3044 T13558 T13556 attr evidence,is
R3045 T13559 T13560 mark that,influence
R3046 T13560 T13558 acl influence,evidence
R3048 T13561 T13562 compound background,genes
R3049 T13562 T13560 nsubj genes,influence
R3050 T13563 T13560 aux may,influence
R3051 T13564 T13565 det the,expression
R3052 T13565 T13560 dobj expression,influence
R3053 T13566 T13565 prep of,expression
R3054 T13567 T13566 pobj autoimmunity,of
R3055 T13568 T13560 prep in,influence
R3056 T13569 T13570 npadvmod gene,targeted
R3057 T13570 T13572 amod targeted,mice
R3058 T13571 T13570 punct -,targeted
R3059 T13572 T13568 pobj mice,in
R3060 T13573 T13556 punct .,is
R3061 T13575 T13576 advmod Here,report
R3062 T13577 T13576 nsubj we,report
R3063 T13578 T13579 dep what,is
R3064 T13579 T13576 ccomp is,report
R3066 T13580 T13579 prep to,is
R3067 T13581 T13582 poss our,knowledge
R3068 T13582 T13580 pobj knowledge,to
R3069 T13583 T13584 det the,study
R3070 T13584 T13579 attr study,is
R3071 T13585 T13584 amod first,study
R3072 T13586 T13584 amod systematic,study
R3073 T13587 T13588 dep that,examined
R3074 T13588 T13584 relcl examined,study
R3075 T13589 T13588 aux has,examined
R3076 T13590 T13588 dobj this,examined
R3077 T13591 T13588 prep in,examined
R3078 T13592 T13593 det the,strains
R3079 T13593 T13591 pobj strains,in
R3080 T13594 T13593 nummod 129,strains
R3081 T13595 T13594 cc and,129
R3082 T13596 T13594 conj C57BL,129
R3083 T13600 T13593 punct ", ",strains
R3084 T13597 T13596 punct /,C57BL
R3085 T13601 T13602 advmod widely,used
R3086 T13602 T13593 acl used,strains
R3087 T13598 T13596 nummod 6,C57BL
R3088 T13603 T13602 prep for,used
R3089 T13604 T13605 compound gene,targeting
R3090 T13605 T13603 pobj targeting,for
R3091 T13599 T13593 compound mouse,strains
R3092 T13606 T13576 punct .,report
R3093 T13608 T13609 poss Our,results
R3094 T13706 T13699 dobj severity,influences
R3095 T13609 T13610 nsubj results,demonstrate
R3096 T13611 T13612 amod interacting,loci
R3097 T13707 T13706 prep of,severity
R3098 T13612 T13610 dobj loci,demonstrate
R3099 T13613 T13612 prep between,loci
R3100 T13614 T13615 nummod 129,mice
R3101 T13708 T13707 pobj glomerulonephritis,of
R3102 T13615 T13613 pobj mice,between
R3103 T13616 T13614 cc and,129
R3104 T13709 T13699 punct ", ",influences
R3105 T13617 T13614 conj C57BL,129
R3106 T13618 T13617 punct /,C57BL
R3107 T13619 T13617 nummod 6,C57BL
R3108 T13710 T13699 cc but,influences
R3109 T13620 T13621 dep that,cause
R3110 T13621 T13612 relcl cause,loci
R3111 T13622 T13621 aux can,cause
R3112 T13711 T13699 conj is,influences
R3113 T13623 T13624 det the,expression
R3114 T13624 T13621 dobj expression,cause
R3115 T13625 T13624 prep of,expression
R3116 T13712 T13711 neg not,is
R3117 T13626 T13627 det a,phenotype
R3118 T13627 T13625 pobj phenotype,of
R3119 T13713 T13714 det the,mover
R3120 T13628 T13627 amod powerful,phenotype
R3121 T13629 T13627 amod autoimmune,phenotype
R3122 T13630 T13621 prep in,cause
R3123 T13714 T13711 attr mover,is
R3124 T13631 T13632 det these,animals
R3125 T13632 T13630 pobj animals,in
R3126 T13633 T13621 punct ", ",cause
R3127 T13715 T13714 amod prime,mover
R3128 T13634 T13621 prep in,cause
R3129 T13716 T13711 prep in,is
R3130 T13717 T13718 det the,induction
R3131 T13635 T13636 det the,absence
R3132 T13636 T13634 pobj absence,in
R3133 T13718 T13716 pobj induction,in
R3134 T13637 T13636 prep of,absence
R3135 T13638 T13639 det any,mutations
R3136 T13639 T13637 pobj mutations,of
R3137 T13640 T13641 npadvmod gene,targeted
R3138 T13641 T13639 amod targeted,mutations
R3139 T13642 T13641 punct -,targeted
R3140 T13719 T13718 prep of,induction
R3141 T13643 T13610 punct .,demonstrate
R3142 T13720 T13721 amod anti-nuclear,autoimmunity
R3143 T13645 T13646 nsubj We,developed
R3144 T13647 T13646 advmod also,developed
R3145 T13721 T13719 pobj autoimmunity,of
R3146 T13648 T13649 det a,strain
R3147 T13649 T13646 dobj strain,developed
R3148 T13722 T13711 punct ", ",is
R3149 T13650 T13649 amod congenic,strain
R3150 T13651 T13649 compound mouse,strain
R3151 T13652 T13649 acl bearing,strain
R3152 T13723 T13711 advcl contrary,is
R3153 T13653 T13654 det a,portion
R3154 T13654 T13652 dobj portion,bearing
R3155 T13655 T13654 prep of,portion
R3156 T13724 T13723 prep to,contrary
R3157 T13656 T13657 nummod 129,Chromosome
R3158 T13657 T13655 pobj Chromosome,of
R3159 T13725 T13726 poss our,interpretation
R3160 T13658 T13657 nummod 1,Chromosome
R3161 T13659 T13652 prep on,bearing
R3162 T13660 T13661 det a,background
R3163 T13726 T13724 pobj interpretation,to
R3164 T13661 T13659 pobj background,on
R3165 T13662 T13661 nmod C57BL,background
R3166 T13663 T13662 punct /,C57BL
R3167 T13727 T13726 amod own,interpretation
R3168 T13664 T13662 nummod 6,C57BL
R3169 T13728 T13726 amod original,interpretation
R3170 T13665 T13646 cc and,developed
R3171 T13666 T13646 conj showed,developed
R3172 T13667 T13668 mark that,expressed
R3173 T13668 T13666 ccomp expressed,showed
R3174 T13729 T13726 prep of,interpretation
R3175 T13669 T13670 det this,line
R3176 T13670 T13668 nsubj line,expressed
R3177 T13671 T13672 amod wild,type
R3178 T13672 T13670 nmod type,line
R3179 T13730 T13731 poss our,data
R3180 T13673 T13672 punct -,type
R3181 T13674 T13670 amod congenic,line
R3182 T13675 T13676 amod striking,autoimmunity
R3183 T13731 T13729 pobj data,of
R3184 T13676 T13668 dobj autoimmunity,expressed
R3185 T13677 T13676 amod anti-nuclear,autoimmunity
R3186 T13678 T13646 punct .,developed
R3187 T13680 T13681 prep By,demonstrated
R3188 T13732 T13733 punct (,Bickerstaff
R3189 T13682 T13680 pcomp comparing,By
R3190 T13683 T13684 det this,strain
R3191 T13684 T13682 dobj strain,comparing
R3192 T13733 T13711 meta Bickerstaff,is
R3193 T13685 T13684 nmod Chromosome,strain
R3194 T13686 T13685 nummod 1,Chromosome
R3195 T13687 T13684 amod congenic,strain
R3196 T13734 T13733 nmod et,Bickerstaff
R3197 T13688 T13682 prep with,comparing
R3198 T13689 T13690 amod matched,mice
R3199 T13690 T13688 pobj mice,with
R3200 T13735 T13733 nmod al.,Bickerstaff
R3201 T13691 T13690 amod congenic,mice
R3202 T13692 T13690 acl lacking,mice
R3203 T13693 T13694 det the,gene
R3204 T13736 T13733 nummod 1999,Bickerstaff
R3205 T13694 T13692 dobj gene,lacking
R3206 T13695 T13694 compound Apcs,gene
R3207 T13696 T13681 punct ", ",demonstrated
R3208 T13737 T13733 punct ),Bickerstaff
R3209 T13697 T13681 nsubj we,demonstrated
R3210 T13698 T13699 mark that,influences
R3211 T13738 T13681 punct .,demonstrated
R3212 T13699 T13681 ccomp influences,demonstrated
R3213 T13700 T13701 compound serum,component
R3214 T13701 T13704 compound component,deficiency
R3215 T13740 T13741 det The,consideration
R3216 T13702 T13701 compound amyloid,component
R3217 T13703 T13701 compound P,component
R3218 T13704 T13699 nsubj deficiency,influences
R3219 T13705 T13706 det the,severity
R3220 T13741 T13743 nsubj consideration,applies
R3221 T13742 T13741 amod same,consideration
R3222 T13744 T13743 prep to,applies
R3223 T13745 T13746 amod other,genes
R3224 T13812 T13810 pcomp is,to
R3225 T13813 T13814 det the,autoimmunity
R3226 T13746 T13744 pobj genes,to
R3227 T13814 T13812 nsubj autoimmunity,is
R3228 T13815 T13814 amod anti-nuclear,autoimmunity
R3229 T13816 T13812 prep due,is
R3230 T13747 T13746 acl located,genes
R3231 T13817 T13816 prep to,due
R3232 T13818 T13819 det the,gene
R3233 T13748 T13747 prep in,located
R3234 T13819 T13817 pobj gene,to
R3235 T13820 T13821 npadvmod gene,targeted
R3236 T13821 T13819 amod targeted,gene
R3237 T13749 T13750 det the,region
R3238 T13822 T13821 punct -,targeted
R3239 T13823 T13819 compound mutant,gene
R3240 T13824 T13817 cc or,to
R3241 T13825 T13817 conj to,to
R3242 T13826 T13827 det the,genes
R3243 T13827 T13825 pobj genes,to
R3244 T13750 T13748 pobj region,in
R3245 T13828 T13827 amod normal,genes
R3246 T13829 T13827 nummod 129,genes
R3247 T13830 T13827 acl expressed,genes
R3248 T13751 T13750 amod same,region
R3249 T13831 T13830 prep in,expressed
R3250 T13832 T13833 det the,region
R3251 T13833 T13831 pobj region,in
R3252 T13752 T13750 nmod Chromosome,region
R3253 T13834 T13833 amod same,region
R3254 T13835 T13833 prep as,region
R3255 T13753 T13752 nummod 1,Chromosome
R3256 T13836 T13837 det the,gene
R3257 T13837 T13835 pobj gene,as
R3258 T13838 T13837 amod targeted,gene
R3259 T13754 T13755 dep that,implicated
R3260 T13839 T13801 punct .,has
R3261 T13755 T13746 relcl implicated,genes
R3262 T13841 T13842 det The,influence
R3263 T13842 T13843 nsubj influence,is
R3264 T13756 T13755 aux have,implicated
R3265 T13844 T13842 prep of,influence
R3266 T13845 T13846 compound background,genes
R3267 T13757 T13755 auxpass been,implicated
R3268 T13846 T13844 pobj genes,of
R3269 T13847 T13842 prep on,influence
R3270 T13848 T13849 det the,development
R3271 T13758 T13755 prep in,implicated
R3272 T13849 T13847 pobj development,on
R3273 T13850 T13849 prep of,development
R3274 T13851 T13852 amod spontaneous,disease
R3275 T13759 T13760 det the,development
R3276 T13852 T13850 pobj disease,of
R3277 T13853 T13852 amod autoimmune,disease
R3278 T13760 T13758 pobj development,in
R3279 T13854 T13855 advmod well,known
R3280 T13855 T13843 acomp known,is
R3281 T13856 T13843 punct ", ",is
R3282 T13761 T13760 prep of,development
R3283 T13857 T13858 advmod especially,with
R3284 T13858 T13843 prep with,is
R3285 T13762 T13761 pobj SLE,of
R3286 T13859 T13858 pobj respect,with
R3287 T13860 T13859 prep to,respect
R3288 T13861 T13862 det the,genes
R3289 T13763 T13764 advmod when,inactivated
R3290 T13862 T13860 pobj genes,to
R3291 T13863 T13862 nmod lpr,genes
R3292 T13864 T13863 cc and,lpr
R3293 T13865 T13863 conj Yaa,lpr
R3294 T13866 T13867 compound disease,susceptibility
R3295 T13764 T13755 advcl inactivated,implicated
R3296 T13867 T13862 compound susceptibility,genes
R3297 T13868 T13867 punct -,susceptibility
R3298 T13869 T13843 punct .,is
R3299 T13765 T13764 agent by,inactivated
R3300 T13871 T13872 prep In,accelerates
R3301 T13766 T13765 pobj gene,by
R3302 T13873 T13874 compound MRL,Mp
R3303 T13874 T13876 compound Mp,mice
R3304 T13767 T13766 punct -,gene
R3305 T13875 T13874 punct /,Mp
R3306 T13876 T13871 pobj mice,In
R3307 T13877 T13872 punct ", ",accelerates
R3308 T13768 T13766 amod targeting,gene
R3309 T13878 T13879 det the,presence
R3310 T13879 T13872 nsubj presence,accelerates
R3311 T13880 T13879 prep of,presence
R3312 T13769 T13764 prep in,inactivated
R3313 T13881 T13882 det the,gene
R3314 T13882 T13880 pobj gene,of
R3315 T13883 T13882 compound lpr,gene
R3316 T13770 T13771 nummod 129,cells
R3317 T13884 T13885 det the,development
R3318 T13885 T13872 dobj development,accelerates
R3319 T13886 T13885 prep of,development
R3320 T13771 T13769 pobj cells,in
R3321 T13887 T13888 amod high,level
R3322 T13888 T13889 nmod level,production
R3323 T13772 T13771 amod embryonic,cells
R3324 T13773 T13771 compound stem,cells
R3325 T13889 T13886 pobj production,of
R3326 T13890 T13888 cc and,level
R3327 T13891 T13892 compound broad,spectrum
R3328 T13774 T13764 cc and,inactivated
R3329 T13892 T13888 conj spectrum,level
R3330 T13893 T13892 punct -,spectrum
R3331 T13775 T13776 advmod then,backcrossed
R3332 T13894 T13889 compound auto-Ab,production
R3333 T13895 T13889 cc and,production
R3334 T13776 T13764 conj backcrossed,inactivated
R3335 T13896 T13897 amod lethal,glomerulonephritis
R3336 T13897 T13889 conj glomerulonephritis,production
R3337 T13898 T13889 punct ", ",production
R3338 T13777 T13776 prep onto,backcrossed
R3339 T13899 T13889 prep in,production
R3340 T13900 T13899 pobj addition,in
R3341 T13778 T13779 det a,background
R3342 T13901 T13900 prep to,addition
R3343 T13902 T13903 amod marked,disease
R3344 T13903 T13901 pobj disease,to
R3345 T13904 T13903 amod lymphoproliferative,disease
R3346 T13905 T13872 punct .,accelerates
R3347 T13779 T13777 pobj background,onto
R3348 T13907 T13908 prep In,leads
R3349 T13780 T13779 amod pure,background
R3350 T13909 T13907 pobj contrast,In
R3351 T13910 T13908 punct ", ",leads
R3352 T13911 T13908 nsubj homozygosity,leads
R3353 T13781 T13779 amod genetic,background
R3354 T13912 T13911 prep of,homozygosity
R3355 T13913 T13914 det the,gene
R3356 T13782 T13783 punct (,Bolland
R3357 T13914 T13912 pobj gene,of
R3358 T13915 T13914 compound lpr,gene
R3359 T13916 T13911 prep in,homozygosity
R3360 T13783 T13764 meta Bolland,inactivated
R3361 T13917 T13918 amod other,strains
R3362 T13784 T13783 cc and,Bolland
R3363 T13785 T13783 conj Ravetch,Bolland
R3364 T13786 T13785 nummod 2000,Ravetch
R3365 T13918 T13916 pobj strains,in
R3366 T13919 T13920 amod such,as
R3367 T13787 T13785 punct ;,Ravetch
R3368 T13920 T13918 prep as,strains
R3369 T13921 T13920 pobj C57BL,as
R3370 T13922 T13921 punct /,C57BL
R3371 T13788 T13785 conj Miwa,Ravetch
R3372 T13923 T13921 nummod 6,C57BL
R3373 T13924 T13921 punct ", ",C57BL
R3374 T13789 T13788 nmod et,Miwa
R3375 T13925 T13921 conj AKR,C57BL
R3376 T13926 T13925 punct ", ",AKR
R3377 T13927 T13928 compound LG,J
R3378 T13790 T13788 nmod al.,Miwa
R3379 T13928 T13925 conj J,AKR
R3380 T13929 T13928 punct /,J
R3381 T13930 T13928 punct ", ",J
R3382 T13791 T13788 nummod 2002,Miwa
R3383 T13931 T13928 cc and,J
R3384 T13932 T13928 conj C3H,J
R3385 T13792 T13788 punct ;,Miwa
R3386 T13933 T13908 advmod only,leads
R3387 T13934 T13908 prep to,leads
R3388 T13935 T13936 compound auto-Ab,production
R3389 T13793 T13788 conj Wu,Miwa
R3390 T13936 T13934 pobj production,to
R3391 T13794 T13793 nmod et,Wu
R3392 T13795 T13793 nmod al.,Wu
R3393 T13937 T13938 punct (,Izui
R3394 T13938 T13908 meta Izui,leads
R3395 T13939 T13938 nmod et,Izui
R3396 T13940 T13938 nmod al.,Izui
R3397 T13941 T13938 nummod 1984,Izui
R3398 T13796 T13793 nummod 2002,Wu
R3399 T13942 T13938 punct ),Izui
R3400 T13943 T13908 punct .,leads
R3401 T13797 T13793 punct ),Wu
R3402 T13945 T13946 advmod Similarly,enhances
R3403 T13798 T13743 punct .,applies
R3404 T13947 T13946 punct ", ",enhances
R3405 T13948 T13949 det the,gene
R3406 T13949 T13946 nsubj gene,enhances
R3407 T13800 T13801 prep For,has
R3408 T13950 T13951 compound Y,chromosome
R3409 T13951 T13953 npadvmod chromosome,linked
R3410 T13952 T13951 punct -,chromosome
R3411 T13953 T13949 amod linked,gene
R3412 T13802 T13800 pobj each,For
R3413 T13954 T13953 punct -,linked
R3414 T13955 T13949 compound Yaa,gene
R3415 T13956 T13949 prep in,gene
R3416 T13957 T13958 nmod BXSB,males
R3417 T13803 T13801 punct ", ",has
R3418 T13958 T13956 pobj males,in
R3419 T13959 T13957 cc and,BXSB
R3420 T13960 T13961 compound MRL,Mp
R3421 T13804 T13801 expl there,has
R3422 T13961 T13957 conj Mp,BXSB
R3423 T13962 T13961 punct /,Mp
R3424 T13963 T13964 det the,development
R3425 T13805 T13806 aux to,be
R3426 T13964 T13946 dobj development,enhances
R3427 T13965 T13964 amod rapid,development
R3428 T13966 T13964 prep of,development
R3429 T13806 T13801 xcomp be,has
R3430 T13967 T13966 pobj auto-Abs,of
R3431 T13968 T13967 cc and,auto-Abs
R3432 T13969 T13967 conj glomerulonephritis,auto-Abs
R3433 T13807 T13808 det a,question
R3434 T13970 T13971 punct (,Izui
R3435 T13971 T13946 meta Izui,enhances
R3436 T13972 T13971 nmod et,Izui
R3437 T13808 T13806 attr question,be
R3438 T13973 T13971 nmod al.,Izui
R3439 T13809 T13808 prep as,question
R3440 T13810 T13809 prep to,as
R3441 T13974 T13971 nummod 1988,Izui
R3442 T13975 T13971 punct ;,Izui
R3443 T13811 T13812 mark whether,is
R3444 T13976 T13971 nmod Merino,Izui
R3445 T13977 T13971 nmod et,Izui
R3446 T13978 T13971 nmod al.,Izui
R3447 T13979 T13971 nummod 1989,Izui
R3448 T13980 T13971 punct ),Izui
R3449 T14023 T14022 prep of,expression
R3450 T13981 T13946 punct .,enhances
R3451 T13983 T13984 advmod However,lead
R3452 T13985 T13984 punct ", ",lead
R3453 T14024 T14023 pobj autoimmunity,of
R3454 T13986 T13984 prep in,lead
R3455 T13987 T13988 det the,background
R3456 T13988 T13986 pobj background,in
R3457 T14025 T14012 aux have,reported
R3458 T13989 T13988 nmod C57BL,background
R3459 T13990 T13989 punct /,C57BL
R3460 T14026 T14012 advmod also,reported
R3461 T13991 T13989 nummod 6,C57BL
R3462 T13992 T13984 punct ", ",lead
R3463 T13993 T13994 det the,gene
R3464 T14027 T14012 auxpass been,reported
R3465 T13994 T13984 nsubj gene,lead
R3466 T13995 T13994 compound Yaa,gene
R3467 T13996 T13984 aux does,lead
R3468 T14028 T14012 prep in,reported
R3469 T13997 T13984 neg not,lead
R3470 T13998 T13984 prep to,lead
R3471 T13999 T14000 det an,phenotype
R3472 T14029 T14030 npadvmod gene,targeted
R3473 T14000 T13998 pobj phenotype,to
R3474 T14001 T14000 amod autoimmune,phenotype
R3475 T14002 T14003 punct (,Izui
R3476 T14030 T14032 amod targeted,mice
R3477 T14003 T13984 meta Izui,lead
R3478 T14004 T14003 nmod et,Izui
R3479 T14005 T14003 nmod al.,Izui
R3480 T14031 T14030 punct -,targeted
R3481 T14006 T14003 nummod 1988,Izui
R3482 T14007 T14003 punct ),Izui
R3483 T14008 T13984 punct .,lead
R3484 T14032 T14028 pobj mice,in
R3485 T14010 T14011 neg Not,surprisingly
R3486 T14033 T14034 punct (,Bolland
R3487 T14011 T14012 advmod surprisingly,reported
R3488 T14034 T14012 meta Bolland,reported
R3489 T14013 T14012 punct ", ",reported
R3490 T14014 T14015 amod important,effects
R3491 T14015 T14012 nsubjpass effects,reported
R3492 T14035 T14034 cc and,Bolland
R3493 T14016 T14015 prep of,effects
R3494 T14017 T14018 det the,background
R3495 T14036 T14034 conj Ravetch,Bolland
R3496 T14018 T14016 pobj background,of
R3497 T14019 T14018 amod genetic,background
R3498 T14020 T14015 prep on,effects
R3499 T14021 T14022 det the,expression
R3500 T14022 T14020 pobj expression,on
R3501 T14037 T14036 nummod 2000,Ravetch
R3502 T14038 T14036 punct ;,Ravetch
R3503 T14039 T14036 conj Santiago,Ravetch
R3504 T14129 T14125 relcl depended,pattern
R3505 T14040 T14039 punct -,Santiago
R3506 T14130 T14128 pobj which,in
R3507 T14131 T14132 det a,phenotype
R3508 T14132 T14129 nsubj phenotype,depended
R3509 T14041 T14039 nmod Raber,Santiago
R3510 T14133 T14132 amod positive,phenotype
R3511 T14042 T14039 nmod et,Santiago
R3512 T14134 T14129 prep upon,depended
R3513 T14043 T14039 nmod al.,Santiago
R3514 T14135 T14136 det the,presence
R3515 T14136 T14134 pobj presence,upon
R3516 T14137 T14136 prep of,presence
R3517 T14044 T14039 nummod 2001,Santiago
R3518 T14138 T14139 amod multiple,loci
R3519 T14139 T14137 pobj loci,of
R3520 T14045 T14039 punct ;,Santiago
R3521 T14140 T14139 amod discrete,loci
R3522 T14141 T14139 compound susceptibility,loci
R3523 T14142 T14129 prep with,depended
R3524 T14046 T14039 conj Mitchell,Santiago
R3525 T14143 T14144 det no,locus
R3526 T14144 T14146 nsubj locus,being
R3527 T14145 T14144 amod single,locus
R3528 T14047 T14046 nmod et,Mitchell
R3529 T14146 T14142 pcomp being,with
R3530 T14147 T14148 det a,factor
R3531 T14148 T14146 attr factor,being
R3532 T14048 T14046 nmod al.,Mitchell
R3533 T14149 T14148 amod prerequisite,factor
R3534 T14150 T14108 punct .,shown
R3535 T14049 T14046 nummod 2002,Mitchell
R3536 T14152 T14153 nsubj We,employed
R3537 T14050 T14046 punct ),Mitchell
R3538 T14154 T14153 aux have,employed
R3539 T14155 T14156 det the,approach
R3540 T14156 T14153 dobj approach,employed
R3541 T14051 T14012 punct .,reported
R3542 T14157 T14156 amod same,approach
R3543 T14158 T14159 aux to,analyse
R3544 T14159 T14153 advcl analyse,employed
R3545 T14053 T14054 advmod Thus,exists
R3546 T14160 T14161 det the,basis
R3547 T14161 T14159 dobj basis,analyse
R3548 T14162 T14161 amod genetic,basis
R3549 T14163 T14161 prep of,basis
R3550 T14164 T14165 compound disease,inheritance
R3551 T14165 T14163 pobj inheritance,of
R3552 T14166 T14161 prep in,basis
R3553 T14055 T14054 punct ", ",exists
R3554 T14167 T14168 det the,strain
R3555 T14168 T14166 pobj strain,in
R3556 T14169 T14168 punct (,strain
R3557 T14170 T14168 nummod 129,strain
R3558 T14056 T14054 nsubj SLE,exists
R3559 T14171 T14170 punct ×,129
R3560 T14172 T14170 appos C57BL,129
R3561 T14173 T14172 punct /,C57BL
R3562 T14057 T14054 prep as,exists
R3563 T14174 T14172 nummod 6,C57BL
R3564 T14175 T14168 punct ),strain
R3565 T14058 T14059 det a,disorder
R3566 T14176 T14168 compound hybrid,strain
R3567 T14177 T14168 punct ", ",strain
R3568 T14178 T14179 det the,background
R3569 T14059 T14057 pobj disorder,as
R3570 T14179 T14168 appos background,strain
R3571 T14180 T14181 advmod most,common
R3572 T14181 T14179 amod common,background
R3573 T14060 T14061 amod complex,trait
R3574 T14182 T14179 amod genetic,background
R3575 T14183 T14179 prep in,background
R3576 T14184 T14185 npadvmod gene,targeted
R3577 T14061 T14059 compound trait,disorder
R3578 T14185 T14187 amod targeted,mice
R3579 T14186 T14185 punct -,targeted
R3580 T14187 T14183 pobj mice,in
R3581 T14062 T14061 punct -,trait
R3582 T14188 T14153 punct .,employed
R3583 T14063 T14064 prep in,required
R3584 T14190 T14191 mark Although,documented
R3585 T14191 T14197 advcl documented,described
R3586 T14192 T14193 amod spontaneous,autoimmunity
R3587 T14064 T14059 relcl required,disorder
R3588 T14193 T14191 nsubjpass autoimmunity,documented
R3589 T14194 T14191 aux has,documented
R3590 T14195 T14191 neg not,documented
R3591 T14065 T14063 pobj which,in
R3592 T14196 T14191 auxpass been,documented
R3593 T14066 T14067 amod specific,combinations
R3594 T14198 T14191 prep in,documented
R3595 T14199 T14198 pobj either,in
R3596 T14200 T14199 prep of,either
R3597 T14067 T14064 nsubjpass combinations,required
R3598 T14201 T14202 det the,strains
R3599 T14202 T14200 pobj strains,of
R3600 T14068 T14067 prep of,combinations
R3601 T14203 T14202 amod pure,strains
R3602 T14204 T14202 nummod 129,strains
R3603 T14205 T14204 cc or,129
R3604 T14206 T14204 conj C57BL,129
R3605 T14207 T14206 punct /,C57BL
R3606 T14069 T14070 compound susceptibility,alleles
R3607 T14208 T14206 nummod 6,C57BL
R3608 T14209 T14197 punct ", ",described
R3609 T14070 T14068 pobj alleles,of
R3610 T14210 T14211 det a,phenotype
R3611 T14211 T14197 nsubjpass phenotype,described
R3612 T14212 T14211 amod spontaneous,phenotype
R3613 T14071 T14064 auxpass are,required
R3614 T14213 T14214 npadvmod lupus,like
R3615 T14214 T14211 amod like,phenotype
R3616 T14215 T14214 punct -,like
R3617 T14072 T14064 prep for,required
R3618 T14216 T14197 aux has,described
R3619 T14217 T14197 auxpass been,described
R3620 T14218 T14197 prep in,described
R3621 T14073 T14074 det the,expression
R3622 T14074 T14072 pobj expression,for
R3623 T14219 T14220 punct (,strains
R3624 T14220 T14218 pobj strains,in
R3625 T14075 T14074 prep of,expression
R3626 T14221 T14220 nummod 129,strains
R3627 T14222 T14221 punct ×,129
R3628 T14223 T14221 appos C57BL,129
R3629 T14076 T14077 det the,phenotype
R3630 T14224 T14223 punct /,C57BL
R3631 T14225 T14223 nummod 6,C57BL
R3632 T14077 T14075 pobj phenotype,of
R3633 T14226 T14220 punct ),strains
R3634 T14227 T14220 compound hybrid,strains
R3635 T14228 T14229 punct (,Obata
R3636 T14078 T14077 amod full,phenotype
R3637 T14229 T14197 meta Obata,described
R3638 T14230 T14229 nmod et,Obata
R3639 T14231 T14229 nmod al.,Obata
R3640 T14079 T14054 punct .,exists
R3641 T14232 T14229 nummod 1979,Obata
R3642 T14233 T14229 punct ;,Obata
R3643 T14234 T14229 nmod Botto,Obata
R3644 T14081 T14082 prep Through,made
R3645 T14083 T14084 det the,use
R3646 T14235 T14229 nmod et,Obata
R3647 T14236 T14229 nmod al.,Obata
R3648 T14084 T14081 pobj use,Through
R3649 T14237 T14229 nummod 1998,Obata
R3650 T14238 T14229 punct ;,Obata
R3651 T14239 T14229 nmod Bickerstaff,Obata
R3652 T14085 T14084 prep of,use
R3653 T14240 T14229 nmod et,Obata
R3654 T14241 T14229 nmod al.,Obata
R3655 T14242 T14229 nummod 1999,Obata
R3656 T14243 T14229 punct ;,Obata
R3657 T14244 T14229 nmod Santiago,Obata
R3658 T14245 T14229 punct -,Obata
R3659 T14086 T14087 compound microsatellite,maps
R3660 T14246 T14229 nmod Raber,Obata
R3661 T14247 T14229 nmod et,Obata
R3662 T14248 T14229 nmod al.,Obata
R3663 T14087 T14085 pobj maps,of
R3664 T14249 T14229 nummod 2001,Obata
R3665 T14250 T14229 punct ),Obata
R3666 T14088 T14087 compound marker,maps
R3667 T14251 T14197 punct ", ",described
R3668 T14252 T14197 advcl suggesting,described
R3669 T14089 T14082 punct ", ",made
R3670 T14253 T14254 mark that,arise
R3671 T14254 T14252 ccomp arise,suggesting
R3672 T14255 T14256 det the,predisposition
R3673 T14090 T14091 det the,identification
R3674 T14256 T14254 nsubj predisposition,arise
R3675 T14257 T14256 prep in,predisposition
R3676 T14258 T14259 det these,mice
R3677 T14091 T14082 nsubjpass identification,made
R3678 T14259 T14257 pobj mice,in
R3679 T14260 T14259 amod hybrid,mice
R3680 T14261 T14254 aux may,arise
R3681 T14092 T14091 prep of,identification
R3682 T14262 T14254 prep as,arise
R3683 T14263 T14264 det a,result
R3684 T14093 T14094 amod murine,intervals
R3685 T14264 T14262 pobj result,as
R3686 T14265 T14264 prep of,result
R3687 T14266 T14267 det the,interaction
R3688 T14094 T14092 pobj intervals,of
R3689 T14267 T14265 pobj interaction,of
R3690 T14268 T14267 prep between,interaction
R3691 T14269 T14270 amod specific,combinations
R3692 T14095 T14096 compound SLE,susceptibility
R3693 T14270 T14268 pobj combinations,between
R3694 T14271 T14270 prep of,combinations
R3695 T14272 T14271 pobj alleles,of
R3696 T14096 T14094 compound susceptibility,intervals
R3697 T14273 T14272 acl inherited,alleles
R3698 T14274 T14273 prep from,inherited
R3699 T14097 T14091 prep in,identification
R3700 T14275 T14276 preconj both,strains
R3701 T14276 T14274 pobj strains,from
R3702 T14277 T14276 det the,strains
R3703 T14098 T14099 amod experimental,crosses
R3704 T14278 T14276 nummod 129,strains
R3705 T14279 T14278 cc and,129
R3706 T14280 T14278 conj C57BL,129
R3707 T14281 T14280 punct /,C57BL
R3708 T14282 T14280 nummod 6,C57BL
R3709 T14099 T14097 pobj crosses,in
R3710 T14283 T14276 amod parental,strains
R3711 T14284 T14197 punct .,described
R3712 T14100 T14082 aux has,made
R3713 T14286 T14287 nsubjpass This,confirmed
R3714 T14288 T14287 auxpass was,confirmed
R3715 T14101 T14082 auxpass been,made
R3716 T14289 T14287 agent by,confirmed
R3717 T14102 T14082 oprd possible,made
R3718 T14290 T14291 det the,study
R3719 T14291 T14289 pobj study,by
R3720 T14292 T14291 compound mapping,study
R3721 T14293 T14291 acl reported,study
R3722 T14103 T14082 punct .,made
R3723 T14294 T14293 advmod here,reported
R3724 T14295 T14287 punct .,confirmed
R3725 T14105 T14106 det These,studies
R3726 T14297 T14298 nsubj We,showed
R3727 T14299 T14300 mark that,are
R3728 T14300 T14298 ccomp are,showed
R3729 T14106 T14108 nsubj studies,shown
R3730 T14301 T14300 expl there,are
R3731 T14302 T14303 amod multiple,loci
R3732 T14107 T14106 compound mapping,studies
R3733 T14109 T14108 aux have,shown
R3734 T14303 T14300 attr loci,are
R3735 T14304 T14303 amod genetic,loci
R3736 T14305 T14303 acl contributing,loci
R3737 T14306 T14305 prep to,contributing
R3738 T14110 T14111 mark that,followed
R3739 T14307 T14308 det the,disease
R3740 T14308 T14306 pobj disease,to
R3741 T14111 T14108 ccomp followed,shown
R3742 T14309 T14298 cc and,showed
R3743 T14310 T14311 nsubjpass these,derived
R3744 T14311 T14298 conj derived,showed
R3745 T14112 T14113 det the,expression
R3746 T14312 T14311 auxpass are,derived
R3747 T14313 T14311 prep from,derived
R3748 T14113 T14111 nsubj expression,followed
R3749 T14314 T14315 preconj both,129
R3750 T14315 T14316 nummod 129,mice
R3751 T14114 T14113 compound disease,expression
R3752 T14316 T14313 pobj mice,from
R3753 T14317 T14315 cc and,129
R3754 T14318 T14315 conj C57BL,129
R3755 T14115 T14113 prep in,expression
R3756 T14319 T14318 punct /,C57BL
R3757 T14320 T14318 nummod 6,C57BL
R3758 T14321 T14311 punct .,derived
R3759 T14323 T14324 nsubj We,demonstrated
R3760 T14116 T14115 pobj relation,in
R3761 T14117 T14116 prep to,relation
R3762 T14325 T14326 mark that,was
R3763 T14118 T14119 det the,inheritance
R3764 T14326 T14324 ccomp was,demonstrated
R3765 T14327 T14328 det a,segment
R3766 T14119 T14117 pobj inheritance,to
R3767 T14328 T14326 nsubj segment,was
R3768 T14329 T14330 advmod 129,derived
R3769 T14330 T14328 amod derived,segment
R3770 T14120 T14119 prep of,inheritance
R3771 T14331 T14330 punct -,derived
R3772 T14332 T14328 prep of,segment
R3773 T14333 T14332 pobj Chromosome,of
R3774 T14121 T14122 det the,alleles
R3775 T14334 T14333 nummod 1,Chromosome
R3776 T14335 T14336 advmod strongly,linked
R3777 T14122 T14120 pobj alleles,of
R3778 T14336 T14326 acomp linked,was
R3779 T14337 T14336 prep to,linked
R3780 T14338 T14339 det the,expression
R3781 T14123 T14122 amod different,alleles
R3782 T14339 T14337 pobj expression,to
R3783 T14340 T14339 prep of,expression
R3784 T14124 T14125 det a,pattern
R3785 T14125 T14111 dobj pattern,followed
R3786 T14126 T14125 compound threshold,pattern
R3787 T14341 T14340 pobj auto-Abs,of
R3788 T14127 T14125 compound liability,pattern
R3789 T14342 T14324 punct .,demonstrated
R3790 T14128 T14129 prep in,depended
R3791 T14344 T14345 det This,region
R3792 T14345 T14346 nsubj region,is
R3793 T14447 T14414 prep to,mapped
R3794 T14346 T14347 ccomp is,occur
R3795 T14348 T14346 advmod probably,is
R3796 T14349 T14346 acomp capable,is
R3797 T14448 T14449 det a,portion
R3798 T14350 T14349 prep of,capable
R3799 T14351 T14350 pcomp causing,of
R3800 T14352 T14353 det the,initiation
R3801 T14449 T14447 pobj portion,to
R3802 T14353 T14351 dobj initiation,causing
R3803 T14354 T14353 prep of,initiation
R3804 T14450 T14449 prep of,portion
R3805 T14355 T14356 det a,response
R3806 T14356 T14354 pobj response,of
R3807 T14357 T14356 amod humoral,response
R3808 T14451 T14450 pobj Chromosome,of
R3809 T14358 T14356 amod autoimmune,response
R3810 T14359 T14356 prep to,response
R3811 T14360 T14361 amod nuclear,antigens
R3812 T14361 T14359 pobj antigens,to
R3813 T14362 T14347 punct ;,occur
R3814 T14363 T14347 advmod however,occur
R3815 T14452 T14451 nummod 3,Chromosome
R3816 T14364 T14347 punct ", ",occur
R3817 T14365 T14366 det this,response
R3818 T14366 T14347 nsubj response,occur
R3819 T14453 T14449 amod close,portion
R3820 T14367 T14347 aux does,occur
R3821 T14368 T14347 neg not,occur
R3822 T14369 T14347 prep in,occur
R3823 T14454 T14453 prep to,close
R3824 T14370 T14371 det the,absence
R3825 T14371 T14369 pobj absence,in
R3826 T14372 T14371 prep of,absence
R3827 T14455 T14456 det the,region
R3828 T14373 T14374 nmod C57BL,genes
R3829 T14374 T14372 pobj genes,of
R3830 T14456 T14454 pobj region,to
R3831 T14375 T14373 punct /,C57BL
R3832 T14376 T14373 nummod 6,C57BL
R3833 T14377 T14347 punct .,occur
R3834 T14457 T14456 acl identified,region
R3835 T14379 T14380 prep In,identified
R3836 T14458 T14457 prep in,identified
R3837 T14381 T14379 pobj support,In
R3838 T14382 T14381 prep of,support
R3839 T14459 T14460 det this,study
R3840 T14383 T14382 pobj this,of
R3841 T14384 T14380 punct ", ",identified
R3842 T14385 T14380 nsubj we,identified
R3843 T14460 T14458 pobj study,in
R3844 T14386 T14387 det a,segment
R3845 T14387 T14380 dobj segment,identified
R3846 T14388 T14387 nmod C57BL,segment
R3847 T14461 T14462 punct (,Morel
R3848 T14389 T14388 punct /,C57BL
R3849 T14390 T14388 nummod 6,C57BL
R3850 T14462 T14414 meta Morel,mapped
R3851 T14391 T14387 prep on,segment
R3852 T14463 T14462 nmod et,Morel
R3853 T14392 T14391 pobj Chromosome,on
R3854 T14393 T14392 nummod 3,Chromosome
R3855 T14464 T14462 nmod al.,Morel
R3856 T14394 T14387 punct ", ",segment
R3857 T14395 T14396 dep which,interact
R3858 T14396 T14387 relcl interact,segment
R3859 T14465 T14462 nummod 1999,Morel
R3860 T14397 T14396 aux may,interact
R3861 T14398 T14396 prep with,interact
R3862 T14399 T14400 det the,genes
R3863 T14400 T14398 pobj genes,with
R3864 T14401 T14400 nummod 129,genes
R3865 T14402 T14400 prep on,genes
R3866 T14466 T14462 punct ;,Morel
R3867 T14403 T14402 pobj Chromosome,on
R3868 T14404 T14403 nummod 1,Chromosome
R3869 T14467 T14462 nmod Haywood,Morel
R3870 T14405 T14406 aux to,mediate
R3871 T14406 T14396 advcl mediate,interact
R3872 T14407 T14408 det the,loss
R3873 T14468 T14462 nmod et,Morel
R3874 T14408 T14406 dobj loss,mediate
R3875 T14409 T14408 prep of,loss
R3876 T14410 T14409 pobj tolerance,of
R3877 T14469 T14462 nmod al.,Morel
R3878 T14411 T14380 punct .,identified
R3879 T14470 T14462 nummod 2000,Morel
R3880 T14413 T14414 advmod Interestingly,mapped
R3881 T14415 T14414 punct ", ",mapped
R3882 T14471 T14462 punct ),Morel
R3883 T14416 T14417 mark although,is
R3884 T14417 T14414 advcl is,mapped
R3885 T14472 T14414 punct .,mapped
R3886 T14418 T14419 det the,region
R3887 T14419 T14417 nsubj region,is
R3888 T14420 T14419 nmod C57BL,region
R3889 T14474 T14475 advmod Furthermore,linked
R3890 T14421 T14420 punct /,C57BL
R3891 T14422 T14420 nummod 6,C57BL
R3892 T14423 T14424 compound SLE,susceptibility
R3893 T14424 T14419 compound susceptibility,region
R3894 T14476 T14475 punct ", ",linked
R3895 T14425 T14424 punct -,susceptibility
R3896 T14426 T14419 prep on,region
R3897 T14427 T14426 pobj Chromosome,on
R3898 T14428 T14427 nummod 3,Chromosome
R3899 T14429 T14417 acomp novel,is
R3900 T14477 T14478 det the,region
R3901 T14430 T14414 punct ", ",mapped
R3902 T14431 T14432 npadvmod disease,modifying
R3903 T14478 T14475 nsubjpass region,linked
R3904 T14432 T14434 amod modifying,alleles
R3905 T14433 T14432 punct -,modifying
R3906 T14434 T14414 nsubjpass alleles,mapped
R3907 T14435 T14434 acl derived,alleles
R3908 T14479 T14478 prep on,region
R3909 T14436 T14435 prep from,derived
R3910 T14437 T14438 nmod C57BL,strains
R3911 T14438 T14436 pobj strains,from
R3912 T14480 T14479 pobj Chromosome,on
R3913 T14439 T14437 punct /,C57BL
R3914 T14440 T14437 nummod 10,C57BL
R3915 T14441 T14437 cc and,C57BL
R3916 T14442 T14437 conj C57BL,C57BL
R3917 T14443 T14442 punct /,C57BL
R3918 T14444 T14442 nummod 6,C57BL
R3919 T14481 T14480 nummod 7,Chromosome
R3920 T14445 T14414 aux have,mapped
R3921 T14446 T14414 auxpass been,mapped
R3922 T14482 T14478 acl associated,region
R3923 T14483 T14482 prep with,associated
R3924 T14484 T14485 det the,development
R3925 T14485 T14483 pobj development,with
R3926 T14553 T14554 advmod as,as
R3927 T14554 T14552 cc as,enhancing
R3928 T14486 T14485 prep of,development
R3929 T14555 T14554 advmod well,as
R3930 T14556 T14552 conj inhibitory,enhancing
R3931 T14557 T14551 prep from,loci
R3932 T14487 T14488 compound lupus,nephritis
R3933 T14558 T14559 det the,mouse
R3934 T14488 T14486 pobj nephritis,of
R3935 T14559 T14557 pobj mouse,from
R3936 T14489 T14475 aux has,linked
R3937 T14560 T14559 nummod 129,mouse
R3938 T14561 T14538 punct ", ",genome
R3939 T14562 T14538 prep in,genome
R3940 T14490 T14475 auxpass been,linked
R3941 T14563 T14562 pobj addition,in
R3942 T14564 T14563 prep to,addition
R3943 T14491 T14475 prep to,linked
R3944 T14565 T14564 pobj genes,to
R3945 T14566 T14565 acl promoting,genes
R3946 T14567 T14566 dobj autoimmunity,promoting
R3947 T14492 T14493 det the,trait
R3948 T14568 T14566 prep from,promoting
R3949 T14569 T14570 det the,mice
R3950 T14493 T14491 pobj trait,to
R3951 T14570 T14568 pobj mice,from
R3952 T14571 T14570 nmod C57BL,mice
R3953 T14572 T14571 punct /,C57BL
R3954 T14494 T14493 amod same,trait
R3955 T14573 T14571 nummod 6,C57BL
R3956 T14574 T14528 punct .,suggest
R3957 T14495 T14475 prep in,linked
R3958 T14576 T14577 det The,impact
R3959 T14577 T14578 nsubjpass impact,assessed
R3960 T14496 T14497 amod other,models
R3961 T14579 T14580 dep that,have
R3962 T14580 T14577 relcl have,impact
R3963 T14497 T14495 pobj models,in
R3964 T14581 T14582 det these,loci
R3965 T14582 T14580 nsubj loci,have
R3966 T14583 T14582 amod interacting,loci
R3967 T14584 T14580 aux may,have
R3968 T14585 T14577 prep on,impact
R3969 T14586 T14587 det the,disease
R3970 T14498 T14497 amod murine,models
R3971 T14587 T14585 pobj disease,on
R3972 T14588 T14589 npadvmod lupus,like
R3973 T14589 T14587 amod like,disease
R3974 T14499 T14497 prep of,models
R3975 T14590 T14589 punct -,like
R3976 T14591 T14587 amod present,disease
R3977 T14592 T14591 prep in,present
R3978 T14500 T14499 pobj SLE,of
R3979 T14593 T14594 amod several,animals
R3980 T14594 T14592 pobj animals,in
R3981 T14501 T14502 punct (,Santiago
R3982 T14595 T14596 npadvmod gene,targeted
R3983 T14596 T14594 amod targeted,animals
R3984 T14597 T14596 punct -,targeted
R3985 T14502 T14475 meta Santiago,linked
R3986 T14598 T14578 auxpass was,assessed
R3987 T14599 T14578 advmod further,assessed
R3988 T14600 T14578 prep by,assessed
R3989 T14503 T14502 nmod et,Santiago
R3990 T14601 T14600 pcomp comparing,by
R3991 T14602 T14603 nmod Apcs,mice
R3992 T14603 T14601 dobj mice,comparing
R3993 T14504 T14502 nmod al.,Santiago
R3994 T14604 T14602 punct −,Apcs
R3995 T14605 T14602 punct /,Apcs
R3996 T14505 T14502 nummod 1998,Santiago
R3997 T14606 T14602 punct −,Apcs
R3998 T14607 T14601 prep with,comparing
R3999 T14608 T14609 npadvmod Chromosome,matched
R4000 T14506 T14502 punct ;,Santiago
R4001 T14609 T14612 amod matched,controls
R4002 T14610 T14608 nummod 1,Chromosome
R4003 T14611 T14609 advmod genetically,matched
R4004 T14507 T14502 nmod Morel,Santiago
R4005 T14612 T14607 pobj controls,with
R4006 T14613 T14578 punct .,assessed
R4007 T14508 T14502 nmod et,Santiago
R4008 T14615 T14616 prep In,is
R4009 T14509 T14502 nmod al.,Santiago
R4010 T14617 T14618 det the,context
R4011 T14618 T14615 pobj context,In
R4012 T14619 T14618 prep of,context
R4013 T14510 T14502 nummod 1999,Santiago
R4014 T14620 T14621 compound SLE,susceptibility
R4015 T14621 T14619 pobj susceptibility,of
R4016 T14511 T14502 punct ;,Santiago
R4017 T14622 T14616 punct ", ",is
R4018 T14623 T14616 nsubj one,is
R4019 T14624 T14623 prep of,one
R4020 T14625 T14626 det the,regions
R4021 T14626 T14624 pobj regions,of
R4022 T14627 T14628 advmod most,consistently
R4023 T14512 T14502 nmod Xie,Santiago
R4024 T14628 T14629 advmod consistently,mapped
R4025 T14629 T14626 amod mapped,regions
R4026 T14630 T14626 amod non-MHC,regions
R4027 T14513 T14502 nmod et,Santiago
R4028 T14631 T14626 prep of,regions
R4029 T14632 T14633 det the,genome
R4030 T14514 T14502 nmod al.,Santiago
R4031 T14633 T14631 pobj genome,of
R4032 T14634 T14633 compound mouse,genome
R4033 T14635 T14636 det the,segment
R4034 T14515 T14502 nummod 2002,Santiago
R4035 T14636 T14616 attr segment,is
R4036 T14637 T14636 amod telomeric,segment
R4037 T14516 T14502 punct ),Santiago
R4038 T14638 T14636 nmod Chromosome,segment
R4039 T14639 T14638 nummod 1,Chromosome
R4040 T14640 T14636 punct ", ",segment
R4041 T14517 T14475 punct ", ",linked
R4042 T14641 T14642 advmod where,mapped
R4043 T14518 T14475 advcl suggesting,linked
R4044 T14642 T14636 relcl mapped,segment
R4045 T14519 T14520 det the,possibility
R4046 T14643 T14644 amod several,loci
R4047 T14644 T14642 nsubjpass loci,mapped
R4048 T14520 T14518 dobj possibility,suggesting
R4049 T14645 T14644 compound disease,loci
R4050 T14646 T14644 punct ", ",loci
R4051 T14647 T14644 acl designated,loci
R4052 T14521 T14520 prep of,possibility
R4053 T14648 T14647 oprd Sle1,designated
R4054 T14649 T14650 punct (,Morel
R4055 T14650 T14648 meta Morel,Sle1
R4056 T14522 T14523 amod shared,loci
R4057 T14651 T14650 nmod et,Morel
R4058 T14652 T14650 nmod al.,Morel
R4059 T14523 T14521 pobj loci,of
R4060 T14653 T14650 nummod 2001,Morel
R4061 T14654 T14650 punct ),Morel
R4062 T14655 T14648 punct ", ",Sle1
R4063 T14524 T14523 compound susceptibility,loci
R4064 T14656 T14648 conj Nba2,Sle1
R4065 T14657 T14658 punct (,Drake
R4066 T14658 T14656 meta Drake,Nba2
R4067 T14525 T14475 punct .,linked
R4068 T14527 T14528 advcl Taken,suggest
R4069 T14529 T14527 advmod together,Taken
R4070 T14659 T14658 nmod et,Drake
R4071 T14660 T14658 nmod al.,Drake
R4072 T14661 T14658 nummod 1995,Drake
R4073 T14662 T14658 punct ;,Drake
R4074 T14663 T14658 nmod Rozzo,Drake
R4075 T14530 T14531 poss our,results
R4076 T14664 T14658 nmod et,Drake
R4077 T14665 T14658 nmod al.,Drake
R4078 T14531 T14528 nsubj results,suggest
R4079 T14666 T14658 nummod 1996,Drake
R4080 T14667 T14658 punct ;,Drake
R4081 T14668 T14658 nmod Vyse,Drake
R4082 T14532 T14533 det a,contribution
R4083 T14669 T14658 nmod et,Drake
R4084 T14670 T14658 nmod al.,Drake
R4085 T14671 T14658 nummod 1997,Drake
R4086 T14533 T14528 dobj contribution,suggest
R4087 T14672 T14658 punct ),Drake
R4088 T14673 T14656 punct ", ",Nba2
R4089 T14534 T14533 amod complex,contribution
R4090 T14674 T14656 cc and,Nba2
R4091 T14675 T14656 conj Bxs3,Nba2
R4092 T14676 T14677 punct (,Hogarth
R4093 T14535 T14533 amod genetic,contribution
R4094 T14677 T14675 meta Hogarth,Bxs3
R4095 T14678 T14677 nmod et,Hogarth
R4096 T14536 T14533 prep from,contribution
R4097 T14679 T14677 nmod al.,Hogarth
R4098 T14680 T14677 nummod 1998,Hogarth
R4099 T14537 T14538 det the,genome
R4100 T14681 T14677 punct ),Hogarth
R4101 T14682 T14642 punct ", ",mapped
R4102 T14683 T14642 aux have,mapped
R4103 T14538 T14536 pobj genome,from
R4104 T14684 T14642 auxpass been,mapped
R4105 T14685 T14642 prep in,mapped
R4106 T14539 T14538 punct (,genome
R4107 T14686 T14687 npadvmod lupus,prone
R4108 T14687 T14689 amod prone,strains
R4109 T14688 T14687 punct -,prone
R4110 T14540 T14538 nummod 129,genome
R4111 T14689 T14685 pobj strains,in
R4112 T14690 T14616 punct .,is
R4113 T14541 T14540 punct ×,129
R4114 T14692 T14693 advmod Moreover,is
R4115 T14542 T14540 appos C57BL,129
R4116 T14694 T14693 punct ", ",is
R4117 T14695 T14696 det this,region
R4118 T14696 T14693 nsubj region,is
R4119 T14543 T14542 punct /,C57BL
R4120 T14697 T14696 prep of,region
R4121 T14698 T14699 compound mouse,Chromosome
R4122 T14699 T14697 pobj Chromosome,of
R4123 T14700 T14699 nummod 1,Chromosome
R4124 T14701 T14693 acomp orthologous,is
R4125 T14702 T14701 prep to,orthologous
R4126 T14544 T14542 nummod 6,C57BL
R4127 T14703 T14704 det a,region
R4128 T14704 T14702 pobj region,to
R4129 T14705 T14704 prep on,region
R4130 T14545 T14538 punct ),genome
R4131 T14706 T14707 amod human,1q22
R4132 T14546 T14538 amod hybrid,genome
R4133 T14707 T14705 pobj 1q22,on
R4134 T14547 T14538 compound background,genome
R4135 T14708 T14707 compound Chromosome,1q22
R4136 T14709 T14710 punct –,1q25
R4137 T14710 T14707 prep 1q25,1q22
R4138 T14548 T14538 punct ", ",genome
R4139 T14711 T14704 punct ", ",region
R4140 T14712 T14713 dep which,linked
R4141 T14549 T14538 prep with,genome
R4142 T14713 T14704 relcl linked,region
R4143 T14714 T14713 aux has,linked
R4144 T14715 T14713 advmod also,linked
R4145 T14550 T14551 det both,loci
R4146 T14716 T14713 auxpass been,linked
R4147 T14717 T14713 prep with,linked
R4148 T14718 T14719 amod human,SLE
R4149 T14551 T14549 pobj loci,with
R4150 T14719 T14717 pobj SLE,with
R4151 T14720 T14721 punct (,Moser
R4152 T14552 T14551 amod enhancing,loci
R4153 T14721 T14713 meta Moser,linked
R4154 T14722 T14721 nmod et,Moser
R4155 T14723 T14721 nmod al.,Moser
R4156 T14765 T14754 advmod vitro,DNA
R4157 T14724 T14721 nummod 1998,Moser
R4158 T14725 T14721 punct ),Moser
R4159 T14726 T14693 punct .,is
R4160 T14766 T14767 punct (,Pepys
R4161 T14767 T14754 meta Pepys,DNA
R4162 T14728 T14729 det The,gene
R4163 T14729 T14731 nsubj gene,is
R4164 T14768 T14767 nummod 1974,Pepys
R4165 T14730 T14729 compound Apcs,gene
R4166 T14769 T14767 punct ;,Pepys
R4167 T14732 T14731 attr one,is
R4168 T14733 T14732 prep of,one
R4169 T14734 T14735 det the,genes
R4170 T14770 T14767 conj Pepys,Pepys
R4171 T14735 T14733 pobj genes,of
R4172 T14736 T14735 compound candidate,genes
R4173 T14771 T14770 cc and,Pepys
R4174 T14737 T14735 acl known,genes
R4175 T14738 T14739 aux to,lie
R4176 T14739 T14737 xcomp lie,known
R4177 T14740 T14739 prep within,lie
R4178 T14741 T14742 det this,region
R4179 T14772 T14770 conj Butler,Pepys
R4180 T14742 T14740 pobj region,within
R4181 T14743 T14731 punct .,is
R4182 T14773 T14772 nummod 1987,Butler
R4183 T14745 T14746 det The,component
R4184 T14746 T14751 nsubj component,binds
R4185 T14774 T14772 punct ;,Butler
R4186 T14747 T14746 amod human,component
R4187 T14748 T14749 compound serum,P
R4188 T14775 T14772 conj Butler,Butler
R4189 T14749 T14746 compound P,component
R4190 T14750 T14749 compound amyloid,P
R4191 T14776 T14775 nmod et,Butler
R4192 T14752 T14751 advmod avidly,binds
R4193 T14753 T14751 prep to,binds
R4194 T14777 T14775 nmod al.,Butler
R4195 T14754 T14753 pobj DNA,to
R4196 T14755 T14754 punct ", ",DNA
R4197 T14756 T14754 conj chromatin,DNA
R4198 T14778 T14775 nummod 1990,Butler
R4199 T14757 T14756 punct ", ",chromatin
R4200 T14758 T14756 cc and,chromatin
R4201 T14779 T14775 punct ),Butler
R4202 T14759 T14760 amod apoptotic,cells
R4203 T14760 T14756 conj cells,chromatin
R4204 T14761 T14754 prep in,DNA
R4205 T14780 T14753 cc and,to
R4206 T14762 T14763 amod physiological,conditions
R4207 T14763 T14761 pobj conditions,in
R4208 T14764 T14765 advmod in,vitro
R4209 T14781 T14780 advmod also,and
R4210 T14782 T14753 conj to,to
R4211 T14783 T14784 amod exposed,chromatin
R4212 T14784 T14782 pobj chromatin,to
R4213 T14871 T14870 prep of,pathogenesis
R4214 T14785 T14784 cc and,chromatin
R4215 T14872 T14871 pobj SLE,of
R4216 T14873 T14848 punct .,postulated
R4217 T14786 T14787 amod apoptotic,cells
R4218 T14875 T14876 advmod However,found
R4219 T14787 T14784 conj cells,chromatin
R4220 T14877 T14876 punct ", ",found
R4221 T14878 T14876 prep in,found
R4222 T14879 T14880 det this,study
R4223 T14788 T14789 advmod in,vivo
R4224 T14880 T14878 pobj study,in
R4225 T14881 T14876 nsubj we,found
R4226 T14882 T14883 mark that,increased
R4227 T14883 T14876 ccomp increased,found
R4228 T14884 T14885 advmod only,levels
R4229 T14789 T14784 advmod vivo,chromatin
R4230 T14885 T14883 nsubjpass levels,increased
R4231 T14886 T14885 nmod ANA,levels
R4232 T14887 T14886 cc and,ANA
R4233 T14790 T14791 punct (,Hintner
R4234 T14888 T14889 amod anti-chromatin,Ab
R4235 T14889 T14886 conj Ab,ANA
R4236 T14890 T14883 auxpass were,increased
R4237 T14791 T14784 meta Hintner,chromatin
R4238 T14891 T14883 advmod significantly,increased
R4239 T14892 T14883 prep in,increased
R4240 T14893 T14894 det the,mice
R4241 T14792 T14791 nmod et,Hintner
R4242 T14793 T14791 nmod al.,Hintner
R4243 T14894 T14892 pobj mice,in
R4244 T14895 T14894 punct (,mice
R4245 T14794 T14791 nummod 1988,Hintner
R4246 T14896 T14897 nummod 129,F2
R4247 T14897 T14894 nmod F2,mice
R4248 T14898 T14896 punct ×,129
R4249 T14795 T14791 punct ;,Hintner
R4250 T14899 T14896 appos C57BL,129
R4251 T14900 T14899 punct /,C57BL
R4252 T14901 T14899 nummod 6,C57BL
R4253 T14796 T14791 nmod Breathnach,Hintner
R4254 T14902 T14897 punct ),F2
R4255 T14903 T14897 punct .,F2
R4256 T14904 T14897 appos Apcs,F2
R4257 T14797 T14791 nmod et,Hintner
R4258 T14905 T14904 punct −,Apcs
R4259 T14906 T14904 punct /,Apcs
R4260 T14798 T14791 nmod al.,Hintner
R4261 T14907 T14904 punct −,Apcs
R4262 T14908 T14876 punct .,found
R4263 T14799 T14791 nummod 1989,Hintner
R4264 T14910 T14911 det A,explanation
R4265 T14800 T14791 punct ;,Hintner
R4266 T14911 T14913 nsubj explanation,lie
R4267 T14912 T14911 amod possible,explanation
R4268 T14801 T14791 nmod Familian,Hintner
R4269 T14914 T14911 prep for,explanation
R4270 T14915 T14916 det this,discrepancy
R4271 T14802 T14791 nmod et,Hintner
R4272 T14916 T14914 pobj discrepancy,for
R4273 T14917 T14913 aux may,lie
R4274 T14803 T14791 nmod al.,Hintner
R4275 T14918 T14913 prep in,lie
R4276 T14919 T14920 det the,fact
R4277 T14920 T14918 pobj fact,in
R4278 T14921 T14922 mark that,generated
R4279 T14922 T14920 advcl generated,fact
R4280 T14923 T14924 det the,mice
R4281 T14804 T14791 nummod 2001,Hintner
R4282 T14924 T14922 nsubjpass mice,generated
R4283 T14925 T14924 nmod Apcs,mice
R4284 T14926 T14925 punct −,Apcs
R4285 T14805 T14791 punct ),Hintner
R4286 T14927 T14925 punct /,Apcs
R4287 T14928 T14925 punct −,Apcs
R4288 T14929 T14924 acl analysed,mice
R4289 T14806 T14751 punct .,binds
R4290 T14930 T14929 prep in,analysed
R4291 T14931 T14932 det the,study
R4292 T14808 T14809 nsubj We,reported
R4293 T14932 T14930 pobj study,in
R4294 T14933 T14932 amod original,study
R4295 T14934 T14922 auxpass were,generated
R4296 T14935 T14922 prep from,generated
R4297 T14810 T14809 aux have,reported
R4298 T14936 T14937 det a,number
R4299 T14937 T14935 pobj number,from
R4300 T14938 T14937 amod limited,number
R4301 T14939 T14937 prep of,number
R4302 T14811 T14809 advmod previously,reported
R4303 T14940 T14939 pobj founders,of
R4304 T14941 T14922 cc and,generated
R4305 T14942 T14943 mark that,caused
R4306 T14812 T14813 mark that,produce
R4307 T14943 T14922 conj caused,generated
R4308 T14944 T14943 nsubj this,caused
R4309 T14813 T14809 ccomp produce,reported
R4310 T14945 T14943 aux may,caused
R4311 T14946 T14943 aux have,caused
R4312 T14947 T14948 det a,inheritance
R4313 T14814 T14813 punct (,produce
R4314 T14948 T14943 dobj inheritance,caused
R4315 T14949 T14948 amod nonrandom,inheritance
R4316 T14815 T14816 nummod 129,mice
R4317 T14950 T14948 prep of,inheritance
R4318 T14951 T14952 det the,loci
R4319 T14952 T14950 pobj loci,of
R4320 T14816 T14813 nsubj mice,produce
R4321 T14953 T14948 prep from,inheritance
R4322 T14954 T14955 det the,strains
R4323 T14955 T14953 pobj strains,from
R4324 T14817 T14815 punct ×,129
R4325 T14956 T14955 amod parental,strains
R4326 T14957 T14913 punct .,lie
R4327 T14818 T14815 appos C57BL,129
R4328 T14959 T14960 advmod Furthermore,identified
R4329 T14819 T14818 punct /,C57BL
R4330 T14961 T14960 punct ", ",identified
R4331 T14962 T14963 det the,analysis
R4332 T14963 T14960 nsubj analysis,identified
R4333 T14964 T14965 amod whole,genome
R4334 T14965 T14963 compound genome,analysis
R4335 T14820 T14818 nummod 6,C57BL
R4336 T14966 T14965 punct -,genome
R4337 T14967 T14968 det the,region
R4338 T14968 T14960 dobj region,identified
R4339 T14821 T14815 punct ),129
R4340 T14969 T14968 nummod 129,region
R4341 T14970 T14968 acl surrounding,region
R4342 T14971 T14972 det the,gene
R4343 T14972 T14970 dobj gene,surrounding
R4344 T14822 T14815 punct .,129
R4345 T14973 T14972 compound Apcs,gene
R4346 T14974 T14960 prep as,identified
R4347 T14975 T14976 det the,locus
R4348 T14823 T14815 appos Apcs,129
R4349 T14976 T14974 pobj locus,as
R4350 T14824 T14823 punct −,Apcs
R4351 T14825 T14823 punct /,Apcs
R4352 T14977 T14976 amod main,locus
R4353 T14826 T14823 punct −,Apcs
R4354 T14978 T14976 acl contributing,locus
R4355 T14979 T14978 prep to,contributing
R4356 T14827 T14813 advmod spontaneously,produce
R4357 T14980 T14981 det the,development
R4358 T14981 T14979 pobj development,to
R4359 T14828 T14829 det a,range
R4360 T14982 T14981 prep of,development
R4361 T14983 T14982 pobj ANA,of
R4362 T14829 T14813 dobj range,produce
R4363 T14984 T14983 cc and,ANA
R4364 T14830 T14829 amod wide,range
R4365 T14985 T14986 amod anti-chromatin,Ab
R4366 T14986 T14983 conj Ab,ANA
R4367 T14831 T14829 prep of,range
R4368 T14987 T14960 punct .,identified
R4369 T14989 T14990 prep In,failed
R4370 T14832 T14831 pobj ANAs,of
R4371 T14991 T14989 pobj agreement,In
R4372 T14833 T14813 cc and,produce
R4373 T14992 T14991 prep with,agreement
R4374 T14993 T14992 pobj this,with
R4375 T14994 T14990 punct ", ",failed
R4376 T14834 T14813 conj develop,produce
R4377 T14995 T14996 advmod when,carried
R4378 T14996 T14990 advcl carried,failed
R4379 T14835 T14836 amod significant,glomerulonephritis
R4380 T14997 T14996 nsubj we,carried
R4381 T14998 T14996 prt out,carried
R4382 T14999 T15000 det a,comparison
R4383 T15000 T14996 dobj comparison,carried
R4384 T15001 T15000 amod selective,comparison
R4385 T15002 T15000 prep between,comparison
R4386 T14836 T14834 dobj glomerulonephritis,develop
R4387 T15003 T15004 det the,mice
R4388 T15004 T15002 pobj mice,between
R4389 T15005 T15004 punct (,mice
R4390 T14837 T14838 amod immune,complex
R4391 T15006 T15007 nummod 129,F2
R4392 T15007 T15004 nmod F2,mice
R4393 T15008 T15006 punct ×,129
R4394 T14838 T14836 compound complex,glomerulonephritis
R4395 T15009 T15006 appos C57BL,129
R4396 T15010 T15009 punct /,C57BL
R4397 T15011 T15009 nummod 6,C57BL
R4398 T14839 T14840 punct (,Bickerstaff
R4399 T15012 T15007 punct ),F2
R4400 T15013 T15007 punct .,F2
R4401 T15014 T15007 appos Apcs,F2
R4402 T14840 T14834 meta Bickerstaff,develop
R4403 T15015 T15014 punct −,Apcs
R4404 T15016 T15014 punct /,Apcs
R4405 T14841 T14840 nmod et,Bickerstaff
R4406 T15017 T15014 punct −,Apcs
R4407 T15018 T15004 cc and,mice
R4408 T15019 T15020 nmod Chromosome,controls
R4409 T14842 T14840 nmod al.,Bickerstaff
R4410 T15020 T15004 conj controls,mice
R4411 T15021 T15019 nummod 1,Chromosome
R4412 T14843 T14840 nummod 1999,Bickerstaff
R4413 T15022 T15023 advmod genetically,matched
R4414 T15023 T15020 amod matched,controls
R4415 T15024 T14990 punct ", ",failed
R4416 T14844 T14840 punct ),Bickerstaff
R4417 T15025 T14990 nsubj we,failed
R4418 T15026 T15027 aux to,detect
R4419 T15027 T14990 xcomp detect,failed
R4420 T14845 T14809 punct .,reported
R4421 T15028 T15029 det any,difference
R4422 T15029 T15027 dobj difference,detect
R4423 T15030 T15029 amod significant,difference
R4424 T14847 T14848 prep On,postulated
R4425 T15031 T15029 prep in,difference
R4426 T15032 T15033 det the,levels
R4427 T15033 T15031 pobj levels,in
R4428 T15034 T15033 prep of,levels
R4429 T14849 T14850 det the,basis
R4430 T15035 T15036 det these,auto-Abs
R4431 T15036 T15034 pobj auto-Abs,of
R4432 T15037 T15036 nummod two,auto-Abs
R4433 T15038 T14990 punct .,failed
R4434 T15040 T15041 det These,findings
R4435 T15041 T15042 nsubj findings,indicated
R4436 T14850 T14847 pobj basis,On
R4437 T15043 T15042 punct ", ",indicated
R4438 T15044 T15042 advcl taken,indicated
R4439 T15045 T15044 advmod together,taken
R4440 T14851 T14850 prep of,basis
R4441 T15046 T15042 punct ", ",indicated
R4442 T15047 T15048 mark that,caused
R4443 T15048 T15042 ccomp caused,indicated
R4444 T14852 T14853 det these,observations
R4445 T15049 T15050 det the,phenotype
R4446 T15050 T15048 nsubjpass phenotype,caused
R4447 T15051 T15050 acl associated,phenotype
R4448 T14853 T14851 pobj observations,of
R4449 T15052 T15051 prep with,associated
R4450 T15053 T15054 compound Apcs,deficiency
R4451 T15054 T15052 pobj deficiency,with
R4452 T14854 T14848 punct ", ",postulated
R4453 T15055 T15048 auxpass was,caused
R4454 T15056 T15048 agent by,caused
R4455 T15057 T15058 det the,presence
R4456 T14855 T14848 nsubjpass it,postulated
R4457 T15058 T15056 pobj presence,by
R4458 T15059 T15058 prep of,presence
R4459 T14856 T14848 auxpass was,postulated
R4460 T15060 T15061 amod unaltered,genes
R4461 T15061 T15059 pobj genes,of
R4462 T15062 T15061 nummod 129,genes
R4463 T14857 T14858 mark that,contributes
R4464 T15063 T15061 prep from,genes
R4465 T15064 T15065 det the,region
R4466 T15065 T15063 pobj region,from
R4467 T14858 T14848 ccomp contributes,postulated
R4468 T15066 T15065 amod telomeric,region
R4469 T15067 T15065 prep of,region
R4470 T15068 T15067 pobj Chromosome,of
R4471 T14859 T14858 nsubj Apcs,contributes
R4472 T15069 T15068 nummod 1,Chromosome
R4473 T14860 T14858 punct ", ",contributes
R4474 T15070 T15061 acl operating,genes
R4475 T15071 T15070 prep in,operating
R4476 T14861 T14858 prep by,contributes
R4477 T15072 T15073 det the,background
R4478 T15073 T15071 pobj background,in
R4479 T15074 T15073 nmod C57BL,background
R4480 T14862 T14861 pcomp altering,by
R4481 T15075 T15074 punct /,C57BL
R4482 T15076 T15074 nummod 6,C57BL
R4483 T15077 T15073 amod genomic,background
R4484 T14863 T14864 det the,clearance
R4485 T15078 T15042 punct .,indicated
R4486 T15080 T15081 amod Strong,evidence
R4487 T15081 T15083 nsubjpass evidence,provided
R4488 T15082 T15081 amod supportive,evidence
R4489 T14864 T14862 dobj clearance,altering
R4490 T14865 T14864 prep of,clearance
R4491 T14866 T14865 pobj chromatin,of
R4492 T14867 T14858 punct ", ",contributes
R4493 T14868 T14858 prep to,contributes
R4494 T15084 T15081 prep for,evidence
R4495 T15085 T15084 pobj this,for
R4496 T15086 T15083 auxpass was,provided
R4497 T14869 T14870 det the,pathogenesis
R4498 T15087 T15083 agent by,provided
R4499 T15088 T15089 det the,analysis
R4500 T15089 T15087 pobj analysis,by
R4501 T14870 T14868 pobj pathogenesis,to
R4502 T15090 T15089 prep of,analysis
R4503 T15091 T15092 det the,mice
R4504 T15189 T15188 pobj C57BL,onto
R4505 T15092 T15090 pobj mice,of
R4506 T15190 T15189 punct /,C57BL
R4507 T15093 T15092 nmod C57BL,mice
R4508 T15191 T15189 nummod 6,C57BL
R4509 T15094 T15093 punct /,C57BL
R4510 T15095 T15093 nummod 6,C57BL
R4511 T15096 T15089 amod congenic,analysis
R4512 T15192 T15193 det a,gene
R4513 T15097 T15096 prep for,congenic
R4514 T15098 T15099 det this,region
R4515 T15099 T15097 pobj region,for
R4516 T15193 T15187 dobj gene,backcrossing
R4517 T15100 T15099 nummod 129,region
R4518 T15101 T15083 punct .,provided
R4519 T15194 T15193 amod mutated,gene
R4520 T15103 T15104 det The,generation
R4521 T15104 T15105 nsubjpass generation,used
R4522 T15195 T15193 acl located,gene
R4523 T15106 T15104 cc and,generation
R4524 T15107 T15104 conj analysis,generation
R4525 T15196 T15195 prep in,located
R4526 T15108 T15104 prep of,generation
R4527 T15109 T15110 amod congenic,strains
R4528 T15197 T15198 det that,region
R4529 T15110 T15108 pobj strains,of
R4530 T15111 T15105 aux have,used
R4531 T15112 T15105 advmod successfully,used
R4532 T15113 T15105 auxpass been,used
R4533 T15198 T15196 pobj region,in
R4534 T15114 T15115 aux to,dissect
R4535 T15115 T15105 advcl dissect,used
R4536 T15199 T15198 amod chromosomal,region
R4537 T15116 T15117 det the,contribution
R4538 T15117 T15115 dobj contribution,dissect
R4539 T15118 T15117 prep of,contribution
R4540 T15119 T15120 amod individual,alleles
R4541 T15120 T15118 pobj alleles,of
R4542 T15200 T15164 punct ", ",was
R4543 T15121 T15120 compound susceptibility,alleles
R4544 T15122 T15117 prep to,contribution
R4545 T15123 T15124 det a,trait
R4546 T15201 T15164 acomp sufficient,was
R4547 T15124 T15122 pobj trait,to
R4548 T15125 T15124 amod multigenic,trait
R4549 T15126 T15127 amod such,as
R4550 T15202 T15203 aux to,mediate
R4551 T15127 T15124 prep as,trait
R4552 T15128 T15127 pobj SLE,as
R4553 T15129 T15105 punct .,used
R4554 T15203 T15201 xcomp mediate,sufficient
R4555 T15131 T15132 nsubj We,adopted
R4556 T15204 T15205 det the,production
R4557 T15133 T15134 det the,strategy
R4558 T15134 T15132 dobj strategy,adopted
R4559 T15205 T15203 dobj production,mediate
R4560 T15135 T15134 amod same,strategy
R4561 T15136 T15137 aux to,investigate
R4562 T15137 T15132 advcl investigate,adopted
R4563 T15206 T15205 prep of,production
R4564 T15138 T15139 det the,contribution
R4565 T15139 T15137 dobj contribution,investigate
R4566 T15140 T15139 amod relative,contribution
R4567 T15207 T15206 pobj auto-Abs,of
R4568 T15141 T15139 prep of,contribution
R4569 T15142 T15143 det the,segment
R4570 T15143 T15141 pobj segment,of
R4571 T15208 T15158 punct .,demonstrated
R4572 T15144 T15143 nummod 129,segment
R4573 T15145 T15143 nmod Chromosome,segment
R4574 T15210 T15211 prep In,is
R4575 T15146 T15145 nummod 1,Chromosome
R4576 T15147 T15143 cc and,segment
R4577 T15148 T15149 det the,gene
R4578 T15149 T15143 conj gene,segment
R4579 T15212 T15213 det this,context
R4580 T15150 T15149 compound Apcs,gene
R4581 T15151 T15139 prep to,contribution
R4582 T15152 T15153 det each,trait
R4583 T15153 T15151 pobj trait,to
R4584 T15213 T15210 pobj context,In
R4585 T15154 T15153 compound disease,trait
R4586 T15155 T15132 punct .,adopted
R4587 T15214 T15211 punct ", ",is
R4588 T15157 T15158 advcl Using,demonstrated
R4589 T15215 T15211 nsubj it,is
R4590 T15159 T15160 det this,approach
R4591 T15160 T15157 dobj approach,Using
R4592 T15161 T15158 punct ", ",demonstrated
R4593 T15162 T15158 nsubj we,demonstrated
R4594 T15216 T15211 prep of,is
R4595 T15163 T15164 mark that,was
R4596 T15164 T15158 ccomp was,demonstrated
R4597 T15217 T15216 pobj note,of
R4598 T15165 T15166 det the,interval
R4599 T15166 T15164 nsubj interval,was
R4600 T15167 T15166 nummod 129,interval
R4601 T15218 T15219 mark that,reported
R4602 T15168 T15166 prep on,interval
R4603 T15169 T15170 amod distal,Chromosome
R4604 T15219 T15211 ccomp reported,is
R4605 T15170 T15168 pobj Chromosome,on
R4606 T15171 T15170 nummod 1,Chromosome
R4607 T15172 T15164 punct ", ",was
R4608 T15220 T15221 amod several,strains
R4609 T15173 T15174 advmod when,transferred
R4610 T15174 T15164 advcl transferred,was
R4611 T15175 T15174 prep onto,transferred
R4612 T15221 T15219 nsubjpass strains,reported
R4613 T15176 T15177 det the,genome
R4614 T15177 T15175 pobj genome,onto
R4615 T15178 T15177 nmod C57BL,genome
R4616 T15222 T15221 prep of,strains
R4617 T15179 T15178 punct /,C57BL
R4618 T15180 T15178 nummod 6,C57BL
R4619 T15181 T15177 punct ", ",genome
R4620 T15223 T15222 pobj mice,of
R4621 T15182 T15183 det a,combination
R4622 T15183 T15177 appos combination,genome
R4623 T15224 T15223 prep with,mice
R4624 T15184 T15185 advmod commonly,created
R4625 T15185 T15183 acl created,combination
R4626 T15186 T15185 prep by,created
R4627 T15225 T15226 amod targeted,mutations
R4628 T15187 T15186 pcomp backcrossing,by
R4629 T15188 T15187 prep onto,backcrossing
R4630 T15226 T15224 pobj mutations,with
R4631 T15227 T15226 prep of,mutations
R4632 T15228 T15227 pobj genes,of
R4633 T15229 T15228 acl encoded,genes
R4634 T15294 T15295 det the,phenotype
R4635 T15295 T15290 nsubjpass phenotype,described
R4636 T15230 T15229 prep in,encoded
R4637 T15296 T15295 amod autoimmune,phenotype
R4638 T15297 T15290 auxpass was,described
R4639 T15231 T15232 det this,region
R4640 T15298 T15290 prep in,described
R4641 T15299 T15298 pobj mice,in
R4642 T15300 T15301 prep in,generated
R4643 T15301 T15299 relcl generated,mice
R4644 T15302 T15300 pobj which,in
R4645 T15232 T15230 pobj region,in
R4646 T15303 T15304 det the,mutation
R4647 T15304 T15301 nsubj mutation,generated
R4648 T15305 T15304 amod null,mutation
R4649 T15233 T15219 aux have,reported
R4650 T15306 T15301 aux was,generated
R4651 T15307 T15301 prep in,generated
R4652 T15308 T15309 nummod 129,cells
R4653 T15234 T15219 auxpass been,reported
R4654 T15309 T15307 pobj cells,in
R4655 T15310 T15309 amod embryonic,cells
R4656 T15235 T15236 aux to,express
R4657 T15311 T15309 compound stem,cells
R4658 T15312 T15301 cc and,generated
R4659 T15313 T15314 advmod then,backcrossed
R4660 T15236 T15219 xcomp express,reported
R4661 T15314 T15301 conj backcrossed,generated
R4662 T15315 T15314 prep to,backcrossed
R4663 T15237 T15238 det a,illness
R4664 T15316 T15317 det the,C57BL
R4665 T15317 T15315 pobj C57BL,to
R4666 T15318 T15317 punct /,C57BL
R4667 T15238 T15236 dobj illness,express
R4668 T15319 T15317 nummod 6,C57BL
R4669 T15320 T15317 cc or,C57BL
R4670 T15321 T15322 det another,background
R4671 T15239 T15240 npadvmod lupus,like
R4672 T15322 T15317 conj background,C57BL
R4673 T15323 T15322 amod genetic,background
R4674 T15240 T15238 amod like,illness
R4675 T15324 T15290 punct .,described
R4676 T15241 T15240 punct -,like
R4677 T15326 T15327 advmod Thus,postulate
R4678 T15242 T15219 punct ", ",reported
R4679 T15328 T15327 punct ", ",postulate
R4680 T15329 T15327 prep in,postulate
R4681 T15243 T15219 prep including,reported
R4682 T15330 T15329 pobj view,in
R4683 T15331 T15330 prep of,view
R4684 T15244 T15243 pobj mice,including
R4685 T15332 T15333 poss our,findings
R4686 T15333 T15331 pobj findings,of
R4687 T15334 T15327 punct ", ",postulate
R4688 T15245 T15244 acl lacking,mice
R4689 T15335 T15327 nsubj one,postulate
R4690 T15336 T15327 aux may,postulate
R4691 T15246 T15245 dobj FcγRIIB,lacking
R4692 T15337 T15338 mark that,were
R4693 T15338 T15327 ccomp were,postulate
R4694 T15339 T15338 prep in,were
R4695 T15340 T15339 pobj each,in
R4696 T15341 T15340 prep of,each
R4697 T15342 T15343 det these,models
R4698 T15247 T15248 punct (,Bolland
R4699 T15343 T15341 pobj models,of
R4700 T15344 T15343 amod murine,models
R4701 T15345 T15343 prep of,models
R4702 T15248 T15246 meta Bolland,FcγRIIB
R4703 T15346 T15345 pobj SLE,of
R4704 T15347 T15338 punct ", ",were
R4705 T15348 T15349 det the,effects
R4706 T15249 T15248 cc and,Bolland
R4707 T15349 T15338 nsubj effects,were
R4708 T15350 T15349 prep of,effects
R4709 T15250 T15248 conj Ravetch,Bolland
R4710 T15351 T15352 det the,gene
R4711 T15352 T15350 pobj gene,of
R4712 T15353 T15352 amod targeted,gene
R4713 T15251 T15250 nummod 2000,Ravetch
R4714 T15354 T15352 amod null,gene
R4715 T15355 T15338 acomp irrelevant,were
R4716 T15356 T15327 punct .,postulate
R4717 T15252 T15250 punct ),Ravetch
R4718 T15358 T15359 amod Similar,conclusions
R4719 T15253 T15246 punct ", ",FcγRIIB
R4720 T15359 T15360 nsubj conclusions,apply
R4721 T15361 T15360 aux may,apply
R4722 T15254 T15255 compound complement,receptors
R4723 T15362 T15360 prep to,apply
R4724 T15363 T15364 amod other,animals
R4725 T15255 T15246 conj receptors,FcγRIIB
R4726 T15364 T15362 pobj animals,to
R4727 T15365 T15366 npadvmod gene,targeted
R4728 T15366 T15364 amod targeted,animals
R4729 T15256 T15255 punct (,receptors
R4730 T15367 T15366 punct -,targeted
R4731 T15368 T15364 acl carrying,animals
R4732 T15369 T15368 dobj mutations,carrying
R4733 T15257 T15255 appos CR1,receptors
R4734 T15370 T15369 prep of,mutations
R4735 T15371 T15370 pobj genes,of
R4736 T15258 T15257 punct /,CR1
R4737 T15372 T15371 acl mapped,genes
R4738 T15373 T15372 prep in,mapped
R4739 T15374 T15375 det the,allele
R4740 T15259 T15257 nummod 2,CR1
R4741 T15375 T15373 pobj allele,in
R4742 T15376 T15377 advmod 129,derived
R4743 T15377 T15375 amod derived,allele
R4744 T15260 T15255 punct ),receptors
R4745 T15378 T15377 punct -,derived
R4746 T15379 T15375 compound susceptibility,allele
R4747 T15380 T15372 prep on,mapped
R4748 T15381 T15380 pobj Chromosome,on
R4749 T15382 T15381 nummod 7,Chromosome
R4750 T15261 T15262 punct (,Prodeus
R4751 T15383 T15384 punct (,O'Keefe
R4752 T15384 T15360 meta O'Keefe,apply
R4753 T15385 T15384 nmod et,O'Keefe
R4754 T15262 T15255 meta Prodeus,receptors
R4755 T15386 T15384 nmod al.,O'Keefe
R4756 T15387 T15384 nummod 1996,O'Keefe
R4757 T15388 T15384 punct ", ",O'Keefe
R4758 T15263 T15262 nmod et,Prodeus
R4759 T15389 T15384 nummod 1999,O'Keefe
R4760 T15390 T15384 punct ),O'Keefe
R4761 T15391 T15360 punct .,apply
R4762 T15264 T15262 nmod al.,Prodeus
R4763 T15393 T15394 det The,expression
R4764 T15394 T15395 nsubj expression,was
R4765 T15265 T15262 nummod 1998,Prodeus
R4766 T15396 T15394 prep of,expression
R4767 T15266 T15262 punct ;,Prodeus
R4768 T15397 T15398 amod anti-nuclear,autoimmunity
R4769 T15398 T15396 pobj autoimmunity,of
R4770 T15399 T15395 acomp identical,was
R4771 T15267 T15262 nmod Wu,Prodeus
R4772 T15268 T15262 nmod et,Prodeus
R4773 T15269 T15262 nmod al.,Prodeus
R4774 T15400 T15395 advcl comparing,was
R4775 T15401 T15402 det the,congenic
R4776 T15402 T15400 dative congenic,comparing
R4777 T15270 T15262 nummod 2002,Prodeus
R4778 T15403 T15400 prep with,comparing
R4779 T15404 T15405 det the,Apcs
R4780 T15405 T15403 pobj Apcs,with
R4781 T15271 T15262 punct ),Prodeus
R4782 T15406 T15405 punct −,Apcs
R4783 T15407 T15405 punct /,Apcs
R4784 T15408 T15405 punct −,Apcs
R4785 T15272 T15255 punct ", ",receptors
R4786 T15409 T15400 dobj mice,comparing
R4787 T15410 T15395 punct .,was
R4788 T15273 T15255 cc and,receptors
R4789 T15412 T15413 det The,difference
R4790 T15274 T15275 npadvmod decay,accelerating
R4791 T15413 T15415 nsubj difference,was
R4792 T15414 T15413 amod only,difference
R4793 T15275 T15277 amod accelerating,factor
R4794 T15416 T15413 prep in,difference
R4795 T15417 T15416 pobj phenotype,in
R4796 T15276 T15275 punct -,accelerating
R4797 T15418 T15413 prep between,difference
R4798 T15419 T15420 det these,mice
R4799 T15420 T15418 pobj mice,between
R4800 T15421 T15415 prep in,was
R4801 T15277 T15255 conj factor,receptors
R4802 T15422 T15423 det the,expression
R4803 T15423 T15421 pobj expression,in
R4804 T15424 T15423 prep of,expression
R4805 T15278 T15277 punct (,factor
R4806 T15425 T15424 pobj glomerulonephritis,of
R4807 T15426 T15423 punct ", ",expression
R4808 T15427 T15428 dep which,was
R4809 T15279 T15277 appos CD55,factor
R4810 T15428 T15423 relcl was,expression
R4811 T15429 T15430 advmod more,pronounced
R4812 T15430 T15428 acomp pronounced,was
R4813 T15280 T15277 punct ),factor
R4814 T15431 T15428 prep in,was
R4815 T15432 T15433 det the,mice
R4816 T15433 T15431 pobj mice,in
R4817 T15281 T15282 punct (,Miwa
R4818 T15434 T15433 nmod Apcs,mice
R4819 T15435 T15434 punct −,Apcs
R4820 T15436 T15434 punct /,Apcs
R4821 T15282 T15277 meta Miwa,factor
R4822 T15437 T15434 punct −,Apcs
R4823 T15438 T15428 prep compared,was
R4824 T15283 T15282 nmod et,Miwa
R4825 T15439 T15438 prep with,compared
R4826 T15440 T15441 det the,mice
R4827 T15441 T15439 pobj mice,with
R4828 T15284 T15282 nmod al.,Miwa
R4829 T15442 T15441 amod congenic,mice
R4830 T15443 T15415 punct .,was
R4831 T15285 T15282 nummod 2002,Miwa
R4832 T15445 T15446 mark Although,demonstrate
R4833 T15446 T15449 advcl demonstrate,indicate
R4834 T15447 T15448 det these,findings
R4835 T15286 T15282 punct ),Miwa
R4836 T15448 T15446 nsubj findings,demonstrate
R4837 T15450 T15451 mark that,implicated
R4838 T15287 T15211 punct .,is
R4839 T15451 T15446 ccomp implicated,demonstrate
R4840 T15452 T15451 nsubjpass Apcs,implicated
R4841 T15289 T15290 prep In,described
R4842 T15453 T15451 auxpass is,implicated
R4843 T15454 T15451 neg not,implicated
R4844 T15455 T15451 prep in,implicated
R4845 T15456 T15457 det the,processing
R4846 T15457 T15455 pobj processing,in
R4847 T15291 T15292 det each,case
R4848 T15458 T15457 prep of,processing
R4849 T15459 T15458 pobj autoantigens,of
R4850 T15460 T15451 punct ", ",implicated
R4851 T15461 T15462 mark as,suggested
R4852 T15462 T15451 advcl suggested,implicated
R4853 T15463 T15462 nsubjpass it,suggested
R4854 T15464 T15462 aux had,suggested
R4855 T15292 T15289 pobj case,In
R4856 T15465 T15462 advmod previously,suggested
R4857 T15466 T15462 auxpass been,suggested
R4858 T15467 T15449 punct ", ",indicate
R4859 T15293 T15290 punct ", ",described
R4860 T15468 T15449 nsubj they,indicate
R4861 T15469 T15470 mark that,play
R4862 T15470 T15449 ccomp play,indicate
R4863 T15506 T15505 prep to,related
R4864 T15471 T15470 nsubj Apcs,play
R4865 T15472 T15470 aux might,play
R4866 T15473 T15470 advmod still,play
R4867 T15474 T15475 det an,role
R4868 T15507 T15506 pobj Apcs,to
R4869 T15475 T15470 dobj role,play
R4870 T15476 T15475 amod important,role
R4871 T15508 T15484 punct ", ",shown
R4872 T15477 T15475 amod protective,role
R4873 T15478 T15470 prep in,play
R4874 T15509 T15484 aux has,shown
R4875 T15510 T15484 auxpass been,shown
R4876 T15479 T15480 compound lupus,nephritis
R4877 T15480 T15478 pobj nephritis,in
R4878 T15511 T15512 aux to,delay
R4879 T15481 T15449 punct .,indicate
R4880 T15512 T15484 xcomp delay,shown
R4881 T15483 T15484 prep In,shown
R4882 T15485 T15483 pobj support,In
R4883 T15513 T15514 det the,onset
R4884 T15486 T15485 prep of,support
R4885 T15487 T15486 pobj this,of
R4886 T15514 T15512 dobj onset,delay
R4887 T15488 T15484 punct ", ",shown
R4888 T15489 T15490 det the,expression
R4889 T15490 T15484 nsubjpass expression,shown
R4890 T15515 T15514 cc and,onset
R4891 T15491 T15490 prep of,expression
R4892 T15492 T15493 det the,protein
R4893 T15493 T15491 pobj protein,of
R4894 T15516 T15514 conj severity,onset
R4895 T15494 T15493 amod human,protein
R4896 T15495 T15496 npadvmod C,reactive
R4897 T15496 T15493 amod reactive,protein
R4898 T15517 T15514 prep of,onset
R4899 T15497 T15496 punct -,reactive
R4900 T15518 T15519 compound lupus,nephritis
R4901 T15498 T15493 punct ", ",protein
R4902 T15499 T15500 det an,protein
R4903 T15500 T15493 appos protein,protein
R4904 T15501 T15502 amod acute,phase
R4905 T15502 T15500 compound phase,protein
R4906 T15519 T15517 pobj nephritis,of
R4907 T15503 T15502 punct -,phase
R4908 T15504 T15505 advmod closely,related
R4909 T15520 T15512 prep in,delay
R4910 T15505 T15500 amod related,protein
R4911 T15521 T15522 det the,strain
R4912 T15522 T15520 pobj strain,in
R4913 T15523 T15524 compound NZB,W
R4914 T15612 T15580 prep in,lay
R4915 T15613 T15614 det the,interactions
R4916 T15614 T15612 pobj interactions,in
R4917 T15524 T15522 compound W,strain
R4918 T15615 T15614 amod numerous,interactions
R4919 T15616 T15615 cc and,numerous
R4920 T15525 T15524 punct /,W
R4921 T15617 T15615 conj complex,numerous
R4922 T15618 T15614 amod synergistic,interactions
R4923 T15526 T15512 prep by,delay
R4924 T15619 T15618 cc and,synergistic
R4925 T15620 T15618 conj counteractive,synergistic
R4926 T15621 T15614 prep between,interactions
R4927 T15527 T15526 pcomp preventing,by
R4928 T15622 T15623 nummod 129,genes
R4929 T15623 T15621 pobj genes,between
R4930 T15624 T15622 cc and,129
R4931 T15528 T15529 det the,deposition
R4932 T15625 T15622 conj C57BL,129
R4933 T15626 T15625 punct /,C57BL
R4934 T15627 T15625 nummod 6,C57BL
R4935 T15529 T15527 dobj deposition,preventing
R4936 T15628 T15623 acl involved,genes
R4937 T15629 T15628 prep in,involved
R4938 T15530 T15529 prep of,deposition
R4939 T15630 T15631 compound self,tolerance
R4940 T15631 T15629 pobj tolerance,in
R4941 T15632 T15631 punct -,tolerance
R4942 T15531 T15532 amod immune,complexes
R4943 T15633 T15631 cc and,tolerance
R4944 T15634 T15635 compound end,damage
R4945 T15532 T15530 pobj complexes,of
R4946 T15635 T15631 conj damage,tolerance
R4947 T15636 T15635 compound organ,damage
R4948 T15637 T15580 punct .,lay
R4949 T15533 T15527 prep in,preventing
R4950 T15639 T15640 advmod Thus,required
R4951 T15534 T15535 det the,cortex
R4952 T15641 T15640 punct ", ",required
R4953 T15642 T15643 mark whilst,is
R4954 T15643 T15640 advcl is,required
R4955 T15644 T15645 det the,lack
R4956 T15645 T15643 nsubj lack,is
R4957 T15646 T15645 prep of,lack
R4958 T15535 T15533 pobj cortex,in
R4959 T15647 T15648 compound lupus,nephritis
R4960 T15648 T15646 pobj nephritis,of
R4961 T15649 T15645 prep in,lack
R4962 T15536 T15535 amod renal,cortex
R4963 T15650 T15651 det the,mice
R4964 T15651 T15649 pobj mice,in
R4965 T15537 T15538 punct (,Szalai
R4966 T15652 T15651 amod congenic,mice
R4967 T15653 T15643 acomp consistent,is
R4968 T15654 T15653 prep with,consistent
R4969 T15538 T15512 meta Szalai,delay
R4970 T15655 T15656 det the,need
R4971 T15656 T15654 pobj need,with
R4972 T15657 T15656 prep for,need
R4973 T15539 T15538 nmod et,Szalai
R4974 T15658 T15659 amod multiple,genes
R4975 T15659 T15657 pobj genes,for
R4976 T15540 T15538 nmod al.,Szalai
R4977 T15660 T15659 compound susceptibility,genes
R4978 T15661 T15656 prep for,need
R4979 T15662 T15663 det the,expression
R4980 T15541 T15538 nummod 2003,Szalai
R4981 T15663 T15661 pobj expression,for
R4982 T15664 T15663 amod full,expression
R4983 T15665 T15663 prep of,expression
R4984 T15542 T15538 punct ),Szalai
R4985 T15543 T15484 punct .,shown
R4986 T15666 T15665 pobj lupus,of
R4987 T15545 T15546 advcl Consistent,reported
R4988 T15667 T15640 punct ", ",required
R4989 T15668 T15669 amod further,studies
R4990 T15669 T15640 nsubjpass studies,required
R4991 T15670 T15640 aux will,required
R4992 T15547 T15545 prep with,Consistent
R4993 T15671 T15640 auxpass be,required
R4994 T15672 T15673 aux to,elucidate
R4995 T15673 T15640 advcl elucidate,required
R4996 T15674 T15673 advmod fully,elucidate
R4997 T15548 T15547 pobj this,with
R4998 T15675 T15676 det the,role
R4999 T15676 T15673 dobj role,elucidate
R5000 T15549 T15546 punct ", ",reported
R5001 T15677 T15676 prep of,role
R5002 T15678 T15677 pobj Apcs,of
R5003 T15679 T15676 prep in,role
R5004 T15550 T15551 det a,polymorphism
R5005 T15680 T15681 det the,pathogenesis
R5006 T15681 T15679 pobj pathogenesis,in
R5007 T15682 T15681 prep of,pathogenesis
R5008 T15683 T15684 amod renal,damage
R5009 T15684 T15682 pobj damage,of
R5010 T15551 T15546 nsubjpass polymorphism,reported
R5011 T15685 T15640 punct .,required
R5012 T15687 T15688 prep In,demonstrate
R5013 T15552 T15551 acl associated,polymorphism
R5014 T15689 T15687 pobj summary,In
R5015 T15553 T15552 prep with,associated
R5016 T15690 T15688 punct ", ",demonstrate
R5017 T15691 T15692 poss our,findings
R5018 T15692 T15688 nsubj findings,demonstrate
R5019 T15554 T15555 amod reduced,level
R5020 T15693 T15694 det the,impact
R5021 T15694 T15688 dobj impact,demonstrate
R5022 T15555 T15553 pobj level,with
R5023 T15695 T15694 prep of,impact
R5024 T15696 T15697 amod epistatic,interactions
R5025 T15697 T15695 pobj interactions,of
R5026 T15556 T15555 amod basal,level
R5027 T15698 T15697 prep between,interactions
R5028 T15699 T15700 nummod 129,C57BL
R5029 T15557 T15555 prep of,level
R5030 T15700 T15702 nmod C57BL,genomes
R5031 T15701 T15700 cc and,C57BL
R5032 T15702 T15698 pobj genomes,between
R5033 T15558 T15559 npadvmod C,reactive
R5034 T15703 T15700 punct /,C57BL
R5035 T15704 T15700 nummod 6,C57BL
R5036 T15705 T15694 prep on,impact
R5037 T15559 T15561 amod reactive,protein
R5038 T15706 T15707 det the,development
R5039 T15707 T15705 pobj development,on
R5040 T15708 T15707 prep of,development
R5041 T15560 T15559 punct -,reactive
R5042 T15709 T15708 pobj SLE,of
R5043 T15710 T15688 cc and,demonstrate
R5044 T15561 T15557 pobj protein,of
R5045 T15711 T15688 conj illustrate,demonstrate
R5046 T15712 T15713 advmod how,lead
R5047 T15713 T15711 ccomp lead,illustrate
R5048 T15562 T15546 aux has,reported
R5049 T15714 T15715 det these,effects
R5050 T15715 T15713 nsubj effects,lead
R5051 T15563 T15546 auxpass been,reported
R5052 T15716 T15717 compound background,gene
R5053 T15717 T15715 compound gene,effects
R5054 T15564 T15565 aux to,linked
R5055 T15565 T15546 xcomp linked,reported
R5056 T15718 T15713 aux may,lead
R5057 T15566 T15565 auxpass be,linked
R5058 T15719 T15713 prep to,lead
R5059 T15720 T15721 amod incorrect,interpretations
R5060 T15721 T15719 pobj interpretations,to
R5061 T15722 T15723 advmod when,analysing
R5062 T15723 T15713 advcl analysing,lead
R5063 T15567 T15565 prep to,linked
R5064 T15724 T15725 det the,phenotype
R5065 T15725 T15723 dobj phenotype,analysing
R5066 T15726 T15725 amod autoimmune,phenotype
R5067 T15568 T15567 pobj SLE,to
R5068 T15727 T15725 prep of,phenotype
R5069 T15728 T15729 amod specific,disruptions
R5070 T15569 T15565 prep in,linked
R5071 T15729 T15727 pobj disruptions,of
R5072 T15730 T15729 amod genetic,disruptions
R5073 T15731 T15688 punct .,demonstrate
R5074 T15570 T15569 pobj humans,in
R5075 T15571 T15572 punct (,Russell
R5076 T15572 T15565 meta Russell,linked
R5077 T15573 T15572 nmod et,Russell
R5078 T15574 T15572 nmod al.,Russell
R5079 T15575 T15572 nummod 2004,Russell
R5080 T15576 T15572 punct ),Russell
R5081 T15577 T15546 punct .,reported
R5082 T15579 T15580 advmod However,lay
R5083 T15581 T15580 punct ", ",lay
R5084 T15582 T15583 mark as,carried
R5085 T15583 T15580 advcl carried,lay
R5086 T15584 T15585 det the,mice
R5087 T15585 T15583 nsubj mice,carried
R5088 T15586 T15585 amod congenic,mice
R5089 T15587 T15585 cc and,mice
R5090 T15588 T15589 det the,mice
R5091 T15589 T15585 conj mice,mice
R5092 T15590 T15589 nmod Apcs,mice
R5093 T15591 T15590 punct −,Apcs
R5094 T15592 T15590 punct /,Apcs
R5095 T15593 T15590 punct −,Apcs
R5096 T15594 T15595 amod similar,regions
R5097 T15595 T15583 dobj regions,carried
R5098 T15596 T15594 cc but,similar
R5099 T15597 T15596 neg not,but
R5100 T15598 T15594 conj identical,similar
R5101 T15599 T15595 nummod 129,regions
R5102 T15600 T15583 prep on,carried
R5103 T15601 T15600 pobj Chromosome,on
R5104 T15602 T15601 nummod 1,Chromosome
R5105 T15603 T15580 punct ", ",lay
R5106 T15604 T15605 det an,explanation
R5107 T15605 T15580 nsubj explanation,lay
R5108 T15606 T15605 amod alternative,explanation
R5109 T15607 T15605 prep for,explanation
R5110 T15608 T15609 poss our,findings
R5111 T15609 T15607 pobj findings,for
R5112 T15610 T15580 aux may,lay
R5113 T15611 T15580 advmod still,lay