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PMC:509305 / 1717-7186 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2804 13-21 JJ denotes Systemic
T2806 22-27 NN denotes lupus
T2805 28-41 NN denotes erythematosus
T2808 42-43 -LRB- denotes (
T2809 43-46 NN denotes SLE
T2810 46-47 -RRB- denotes )
T2807 48-50 VBZ denotes is
T2811 51-52 DT denotes a
T2813 53-60 JJ denotes chronic
T2814 61-71 JJ denotes autoimmune
T2812 72-79 NN denotes disease
T2815 80-93 VBN denotes characterised
T2816 94-96 IN denotes by
T2817 97-100 DT denotes the
T2818 101-111 NN denotes production
T2819 112-114 IN denotes of
T2820 115-129 NNS denotes autoantibodies
T2821 130-131 -LRB- denotes (
T2822 131-139 NNS denotes auto-Abs
T2823 139-140 -RRB- denotes )
T2824 141-148 IN denotes against
T2825 149-150 DT denotes a
T2827 151-155 JJ denotes wide
T2826 156-164 NN denotes spectrum
T2828 165-167 IN denotes of
T2829 168-172 NN denotes self
T2831 172-173 HYPH denotes -
T2830 173-181 NNS denotes antigens
T2832 181-183 , denotes ,
T2833 183-189 RB denotes mainly
T2834 190-194 IN denotes from
T2835 195-206 JJ denotes subcellular
T2836 207-219 NNS denotes compartments
T2837 219-221 , denotes ,
T2838 221-231 RB denotes especially
T2840 232-235 DT denotes the
T2841 236-240 NN denotes cell
T2839 241-248 NN denotes nucleus
T2842 248-249 . denotes .
T2843 249-446 sentence denotes Genetic predisposition is an important contributor to susceptibility to SLE in both humans and animals (Vyse and Todd 1996; Harley et al. 1998; Theofilopoulos and Kono 1999; Wakeland et al. 2001).
T2844 250-257 JJ denotes Genetic
T2845 258-272 NN denotes predisposition
T2846 273-275 VBZ denotes is
T2847 276-278 DT denotes an
T2849 279-288 JJ denotes important
T2848 289-300 NN denotes contributor
T2850 301-303 IN denotes to
T2851 304-318 NN denotes susceptibility
T2852 319-321 IN denotes to
T2853 322-325 NN denotes SLE
T2854 326-328 IN denotes in
T2855 329-333 CC denotes both
T2856 334-340 NNS denotes humans
T2857 341-344 CC denotes and
T2858 345-352 NNS denotes animals
T2859 353-354 -LRB- denotes (
T2860 354-358 NNP denotes Vyse
T2861 359-362 CC denotes and
T2862 363-367 NNP denotes Todd
T2863 368-372 CD denotes 1996
T2864 372-373 : denotes ;
T2865 374-380 NNP denotes Harley
T2866 381-383 FW denotes et
T2867 384-387 FW denotes al.
T2868 388-392 CD denotes 1998
T2869 392-393 : denotes ;
T2870 394-408 NNP denotes Theofilopoulos
T2871 409-412 CC denotes and
T2872 413-417 NNP denotes Kono
T2873 418-422 CD denotes 1999
T2874 422-423 : denotes ;
T2875 424-432 NNP denotes Wakeland
T2876 433-435 FW denotes et
T2877 436-439 FW denotes al.
T2878 440-444 CD denotes 2001
T2879 444-445 -RRB- denotes )
T2880 445-446 . denotes .
T2881 446-604 sentence denotes Genes in multiple pathways participate in mediating disease pathogenesis, and epistatic interactions amongst these genes influence the expression of disease.
T2882 447-452 NNS denotes Genes
T2884 453-455 IN denotes in
T2885 456-464 JJ denotes multiple
T2886 465-473 NNS denotes pathways
T2883 474-485 VBP denotes participate
T2887 486-488 IN denotes in
T2888 489-498 VBG denotes mediating
T2889 499-506 NN denotes disease
T2890 507-519 NN denotes pathogenesis
T2891 519-521 , denotes ,
T2892 521-524 CC denotes and
T2893 525-534 JJ denotes epistatic
T2894 535-547 NNS denotes interactions
T2896 548-555 IN denotes amongst
T2897 556-561 DT denotes these
T2898 562-567 NNS denotes genes
T2895 568-577 VBP denotes influence
T2899 578-581 DT denotes the
T2900 582-592 NN denotes expression
T2901 593-595 IN denotes of
T2902 596-603 NN denotes disease
T2903 603-604 . denotes .
T2904 604-868 sentence denotes In this context, both genetic linkage studies in spontaneous lupus-prone models and synthetic murine models of autoimmunity generated by targeted disruption of specific genes modulating the immune system have widely been used to investigate the complexity of SLE.
T2905 605-607 IN denotes In
T2907 608-612 DT denotes this
T2908 613-620 NN denotes context
T2909 620-622 , denotes ,
T2910 622-626 CC denotes both
T2912 627-634 JJ denotes genetic
T2913 635-642 NN denotes linkage
T2911 643-650 NNS denotes studies
T2914 651-653 IN denotes in
T2915 654-665 JJ denotes spontaneous
T2917 666-671 NN denotes lupus
T2919 671-672 HYPH denotes -
T2918 672-677 JJ denotes prone
T2916 678-684 NNS denotes models
T2920 685-688 CC denotes and
T2921 689-698 JJ denotes synthetic
T2923 699-705 JJ denotes murine
T2922 706-712 NNS denotes models
T2924 713-715 IN denotes of
T2925 716-728 NN denotes autoimmunity
T2926 729-738 VBN denotes generated
T2927 739-741 IN denotes by
T2928 742-750 VBN denotes targeted
T2929 751-761 NN denotes disruption
T2930 762-764 IN denotes of
T2931 765-773 JJ denotes specific
T2932 774-779 NNS denotes genes
T2933 780-790 VBG denotes modulating
T2934 791-794 DT denotes the
T2936 795-801 JJ denotes immune
T2935 802-808 NN denotes system
T2937 809-813 VBP denotes have
T2938 814-820 RB denotes widely
T2939 821-825 VBN denotes been
T2906 826-830 VBN denotes used
T2940 831-833 TO denotes to
T2941 834-845 VB denotes investigate
T2942 846-849 DT denotes the
T2943 850-860 NN denotes complexity
T2944 861-863 IN denotes of
T2945 864-867 NN denotes SLE
T2946 867-868 . denotes .
T2947 868-1223 sentence denotes The best-studied strains of mice that spontaneously develop a lupus-like pathology are the New Zealand Black/New Zealand White hybrid strain (NZB/WF1); the MRL/Mp lpr/lpr strain, which carries the lpr mutation of the FAS receptor gene; and the BXSB strain, which carries the Y chromosome autoimmune accelerator (Yaa) gene (Theofilopoulos and Dixon 1985).
T2948 869-872 DT denotes The
T2950 873-877 RBS denotes best
T2952 877-878 HYPH denotes -
T2951 878-885 VBN denotes studied
T2949 886-893 NNS denotes strains
T2954 894-896 IN denotes of
T2955 897-901 NNS denotes mice
T2956 902-906 WDT denotes that
T2958 907-920 RB denotes spontaneously
T2957 921-928 VBP denotes develop
T2959 929-930 DT denotes a
T2961 931-936 NN denotes lupus
T2963 936-937 HYPH denotes -
T2962 937-941 JJ denotes like
T2960 942-951 NN denotes pathology
T2953 952-955 VBP denotes are
T2964 956-959 DT denotes the
T2966 960-963 NNP denotes New
T2967 964-971 NNP denotes Zealand
T2968 972-977 NN denotes Black
T2969 977-978 HYPH denotes /
T2970 978-981 NNP denotes New
T2971 982-989 NNP denotes Zealand
T2972 990-995 NN denotes White
T2973 996-1002 NN denotes hybrid
T2965 1003-1009 NN denotes strain
T2974 1010-1011 -LRB- denotes (
T2976 1011-1014 NN denotes NZB
T2977 1014-1015 HYPH denotes /
T2975 1015-1018 NN denotes WF1
T2978 1018-1019 -RRB- denotes )
T2979 1019-1020 : denotes ;
T2980 1021-1024 DT denotes the
T2982 1025-1028 NN denotes MRL
T2984 1028-1029 HYPH denotes /
T2983 1029-1031 NN denotes Mp
T2985 1032-1035 NN denotes lpr
T2987 1035-1036 HYPH denotes /
T2986 1036-1039 NN denotes lpr
T2981 1040-1046 NN denotes strain
T2988 1046-1048 , denotes ,
T2989 1048-1053 WDT denotes which
T2990 1054-1061 VBZ denotes carries
T2991 1062-1065 DT denotes the
T2993 1066-1069 NN denotes lpr
T2992 1070-1078 NN denotes mutation
T2994 1079-1081 IN denotes of
T2995 1082-1085 DT denotes the
T2997 1086-1089 NN denotes FAS
T2998 1090-1098 NN denotes receptor
T2996 1099-1103 NN denotes gene
T2999 1103-1104 : denotes ;
T3000 1105-1108 CC denotes and
T3001 1109-1112 DT denotes the
T3003 1113-1117 NN denotes BXSB
T3002 1118-1124 NN denotes strain
T3004 1124-1126 , denotes ,
T3005 1126-1131 WDT denotes which
T3006 1132-1139 VBZ denotes carries
T3007 1140-1143 DT denotes the
T3009 1144-1145 NN denotes Y
T3010 1146-1156 NN denotes chromosome
T3012 1157-1167 JJ denotes autoimmune
T3011 1168-1179 NN denotes accelerator
T3013 1180-1181 -LRB- denotes (
T3014 1181-1184 NNP denotes Yaa
T3015 1184-1185 -RRB- denotes )
T3008 1186-1190 NN denotes gene
T3016 1191-1192 -LRB- denotes (
T3017 1192-1206 NNP denotes Theofilopoulos
T3018 1207-1210 CC denotes and
T3019 1211-1216 NNP denotes Dixon
T3020 1217-1221 CD denotes 1985
T3021 1221-1222 -RRB- denotes )
T3022 1222-1223 . denotes .
T3023 1223-1353 sentence denotes Extensive genetic mapping studies in all three strains have identified multiple intervals associated with disease susceptibility.
T3024 1224-1233 JJ denotes Extensive
T3026 1234-1241 JJ denotes genetic
T3027 1242-1249 NN denotes mapping
T3025 1250-1257 NNS denotes studies
T3029 1258-1260 IN denotes in
T3030 1261-1264 DT denotes all
T3032 1265-1270 CD denotes three
T3031 1271-1278 NNS denotes strains
T3033 1279-1283 VBP denotes have
T3028 1284-1294 VBN denotes identified
T3034 1295-1303 JJ denotes multiple
T3035 1304-1313 NNS denotes intervals
T3036 1314-1324 VBN denotes associated
T3037 1325-1329 IN denotes with
T3038 1330-1337 NN denotes disease
T3039 1338-1352 NN denotes susceptibility
T3040 1352-1353 . denotes .
T3041 1353-1594 sentence denotes Interestingly, the majority of the intervals detected are strain-specific, confirming the genetic complexity of the disease and indicating the presence of extensive heterogeneity in the genes contributing to the pathogenesis of the disease.
T3042 1354-1367 RB denotes Interestingly
T3044 1367-1369 , denotes ,
T3045 1369-1372 DT denotes the
T3046 1373-1381 NN denotes majority
T3047 1382-1384 IN denotes of
T3048 1385-1388 DT denotes the
T3049 1389-1398 NNS denotes intervals
T3050 1399-1407 VBN denotes detected
T3043 1408-1411 VBP denotes are
T3051 1412-1418 NN denotes strain
T3053 1418-1419 HYPH denotes -
T3052 1419-1427 JJ denotes specific
T3054 1427-1429 , denotes ,
T3055 1429-1439 VBG denotes confirming
T3056 1440-1443 DT denotes the
T3058 1444-1451 JJ denotes genetic
T3057 1452-1462 NN denotes complexity
T3059 1463-1465 IN denotes of
T3060 1466-1469 DT denotes the
T3061 1470-1477 NN denotes disease
T3062 1478-1481 CC denotes and
T3063 1482-1492 VBG denotes indicating
T3064 1493-1496 DT denotes the
T3065 1497-1505 NN denotes presence
T3066 1506-1508 IN denotes of
T3067 1509-1518 JJ denotes extensive
T3068 1519-1532 NN denotes heterogeneity
T3069 1533-1535 IN denotes in
T3070 1536-1539 DT denotes the
T3071 1540-1545 NNS denotes genes
T3072 1546-1558 VBG denotes contributing
T3073 1559-1561 IN denotes to
T3074 1562-1565 DT denotes the
T3075 1566-1578 NN denotes pathogenesis
T3076 1579-1581 IN denotes of
T3077 1582-1585 DT denotes the
T3078 1586-1593 NN denotes disease
T3079 1593-1594 . denotes .
T3080 1594-1787 sentence denotes However, some susceptibility loci have been mapped to similar chromosome locations in different strains, suggesting that at least some susceptibility may be shared amongst lupus-prone strains.
T3081 1595-1602 RB denotes However
T3083 1602-1604 , denotes ,
T3084 1604-1608 DT denotes some
T3086 1609-1623 NN denotes susceptibility
T3085 1624-1628 NNS denotes loci
T3087 1629-1633 VBP denotes have
T3088 1634-1638 VBN denotes been
T3082 1639-1645 VBN denotes mapped
T3089 1646-1648 IN denotes to
T3090 1649-1656 JJ denotes similar
T3092 1657-1667 NN denotes chromosome
T3091 1668-1677 NNS denotes locations
T3093 1678-1680 IN denotes in
T3094 1681-1690 JJ denotes different
T3095 1691-1698 NNS denotes strains
T3096 1698-1700 , denotes ,
T3097 1700-1710 VBG denotes suggesting
T3098 1711-1715 IN denotes that
T3100 1716-1718 RB denotes at
T3101 1719-1724 RBS denotes least
T3103 1725-1729 DT denotes some
T3102 1730-1744 NN denotes susceptibility
T3104 1745-1748 MD denotes may
T3105 1749-1751 VB denotes be
T3099 1752-1758 VBN denotes shared
T3106 1759-1766 IN denotes amongst
T3107 1767-1772 NN denotes lupus
T3109 1772-1773 HYPH denotes -
T3108 1773-1778 JJ denotes prone
T3110 1779-1786 NNS denotes strains
T3111 1786-1787 . denotes .
T3112 1787-2020 sentence denotes Amongst these shared susceptibility loci, the most striking are loci on distal Chromosome 1, for which important contributing genes have been found in New Zealand and BXSB models (Theofilopoulos and Kono 1999; Wakeland et al. 2001).
T3113 1788-1795 IN denotes Amongst
T3115 1796-1801 DT denotes these
T3117 1802-1808 VBN denotes shared
T3118 1809-1823 NN denotes susceptibility
T3116 1824-1828 NNS denotes loci
T3119 1828-1830 , denotes ,
T3120 1830-1833 DT denotes the
T3122 1834-1838 RBS denotes most
T3121 1839-1847 JJ denotes striking
T3114 1848-1851 VBP denotes are
T3123 1852-1856 NNS denotes loci
T3124 1857-1859 IN denotes on
T3125 1860-1866 JJ denotes distal
T3126 1867-1877 NN denotes Chromosome
T3127 1878-1879 CD denotes 1
T3128 1879-1881 , denotes ,
T3129 1881-1884 IN denotes for
T3131 1885-1890 WDT denotes which
T3132 1891-1900 JJ denotes important
T3134 1901-1913 VBG denotes contributing
T3133 1914-1919 NNS denotes genes
T3135 1920-1924 VBP denotes have
T3136 1925-1929 VBN denotes been
T3130 1930-1935 VBN denotes found
T3137 1936-1938 IN denotes in
T3138 1939-1942 NNP denotes New
T3139 1943-1950 NNP denotes Zealand
T3141 1951-1954 CC denotes and
T3142 1955-1959 NN denotes BXSB
T3140 1960-1966 NNS denotes models
T3143 1967-1968 -LRB- denotes (
T3144 1968-1982 NNP denotes Theofilopoulos
T3145 1983-1986 CC denotes and
T3146 1987-1991 NNP denotes Kono
T3147 1992-1996 CD denotes 1999
T3148 1996-1997 : denotes ;
T3149 1998-2006 NNP denotes Wakeland
T3150 2007-2009 FW denotes et
T3151 2010-2013 FW denotes al.
T3152 2014-2018 CD denotes 2001
T3153 2018-2019 -RRB- denotes )
T3154 2019-2020 . denotes .
T3155 2020-2332 sentence denotes Although considerable efforts have been made to identify the genes responsible for the development of the disease, with the exception of the lpr mutation, none of the genetic contributions to disease in the three well-documented murine SLE strains have yet been fully resolved at the molecular or protein level.
T3156 2021-2029 IN denotes Although
T3158 2030-2042 JJ denotes considerable
T3159 2043-2050 NNS denotes efforts
T3160 2051-2055 VBP denotes have
T3161 2056-2060 VBN denotes been
T3157 2061-2065 VBN denotes made
T3163 2066-2068 TO denotes to
T3164 2069-2077 VB denotes identify
T3165 2078-2081 DT denotes the
T3166 2082-2087 NNS denotes genes
T3167 2088-2099 JJ denotes responsible
T3168 2100-2103 IN denotes for
T3169 2104-2107 DT denotes the
T3170 2108-2119 NN denotes development
T3171 2120-2122 IN denotes of
T3172 2123-2126 DT denotes the
T3173 2127-2134 NN denotes disease
T3174 2134-2136 , denotes ,
T3175 2136-2140 IN denotes with
T3176 2141-2144 DT denotes the
T3177 2145-2154 NN denotes exception
T3178 2155-2157 IN denotes of
T3179 2158-2161 DT denotes the
T3181 2162-2165 NN denotes lpr
T3180 2166-2174 NN denotes mutation
T3182 2174-2176 , denotes ,
T3183 2176-2180 NN denotes none
T3184 2181-2183 IN denotes of
T3185 2184-2187 DT denotes the
T3187 2188-2195 JJ denotes genetic
T3186 2196-2209 NNS denotes contributions
T3188 2210-2212 IN denotes to
T3189 2213-2220 NN denotes disease
T3190 2221-2223 IN denotes in
T3191 2224-2227 DT denotes the
T3193 2228-2233 CD denotes three
T3194 2234-2238 RB denotes well
T3196 2238-2239 HYPH denotes -
T3195 2239-2249 VBN denotes documented
T3197 2250-2256 JJ denotes murine
T3198 2257-2260 NN denotes SLE
T3192 2261-2268 NNS denotes strains
T3199 2269-2273 VBP denotes have
T3200 2274-2277 RB denotes yet
T3201 2278-2282 VBN denotes been
T3202 2283-2288 RB denotes fully
T3162 2289-2297 VBN denotes resolved
T3203 2298-2300 IN denotes at
T3204 2301-2304 DT denotes the
T3206 2305-2314 JJ denotes molecular
T3208 2315-2317 CC denotes or
T3207 2318-2325 NN denotes protein
T3205 2326-2331 NN denotes level
T3209 2331-2332 . denotes .
T3210 2332-2494 sentence denotes Thus, targeted genetic disruption of candidate genes encoding proteins of the immune system has been extensively used to examine their role in immune regulation.
T3211 2333-2337 RB denotes Thus
T3213 2337-2339 , denotes ,
T3214 2339-2347 VBN denotes targeted
T3216 2348-2355 JJ denotes genetic
T3215 2356-2366 NN denotes disruption
T3217 2367-2369 IN denotes of
T3218 2370-2379 NN denotes candidate
T3219 2380-2385 NNS denotes genes
T3220 2386-2394 VBG denotes encoding
T3221 2395-2403 NN denotes proteins
T3222 2404-2406 IN denotes of
T3223 2407-2410 DT denotes the
T3225 2411-2417 JJ denotes immune
T3224 2418-2424 NN denotes system
T3226 2425-2428 VBZ denotes has
T3227 2429-2433 VBN denotes been
T3228 2434-2445 RB denotes extensively
T3212 2446-2450 VBN denotes used
T3229 2451-2453 TO denotes to
T3230 2454-2461 VB denotes examine
T3231 2462-2467 PRP$ denotes their
T3232 2468-2472 NN denotes role
T3233 2473-2475 IN denotes in
T3234 2476-2482 JJ denotes immune
T3235 2483-2493 NN denotes regulation
T3236 2493-2494 . denotes .
T3237 2494-2661 sentence denotes However, the most surprising result of this powerful approach has been the high frequency with which such mutations have been associated with an autoimmune phenotype.
T3238 2495-2502 RB denotes However
T3240 2502-2504 , denotes ,
T3241 2504-2507 DT denotes the
T3243 2508-2512 RBS denotes most
T3244 2513-2523 JJ denotes surprising
T3242 2524-2530 NN denotes result
T3245 2531-2533 IN denotes of
T3246 2534-2538 DT denotes this
T3248 2539-2547 JJ denotes powerful
T3247 2548-2556 NN denotes approach
T3249 2557-2560 VBZ denotes has
T3239 2561-2565 VBN denotes been
T3250 2566-2569 DT denotes the
T3252 2570-2574 JJ denotes high
T3251 2575-2584 NN denotes frequency
T3253 2585-2589 IN denotes with
T3255 2590-2595 WDT denotes which
T3256 2596-2600 JJ denotes such
T3257 2601-2610 NNS denotes mutations
T3258 2611-2615 VBP denotes have
T3259 2616-2620 VBN denotes been
T3254 2621-2631 VBN denotes associated
T3260 2632-2636 IN denotes with
T3261 2637-2639 DT denotes an
T3263 2640-2650 JJ denotes autoimmune
T3262 2651-2660 NN denotes phenotype
T3264 2660-2661 . denotes .
T3265 2661-2994 sentence denotes In this regard, it is of note that hybrid strains between 129 and C57BL/6 mice, widely used in the generation of gene-targeted mice, are spontaneously predisposed to development of humoral autoimmunity with low levels of glomerulonephritis (Obata et al. 1979; Botto et al. 1998; Bickerstaff et al. 1999; Santiago-Raber et al. 2001).
T3266 2662-2664 IN denotes In
T3268 2665-2669 DT denotes this
T3269 2670-2676 NN denotes regard
T3270 2676-2678 , denotes ,
T3271 2678-2680 PRP denotes it
T3267 2681-2683 VBZ denotes is
T3272 2684-2686 IN denotes of
T3273 2687-2691 NN denotes note
T3274 2692-2696 IN denotes that
T3276 2697-2703 JJ denotes hybrid
T3277 2704-2711 NNS denotes strains
T3278 2712-2719 IN denotes between
T3279 2720-2723 CD denotes 129
T3281 2724-2727 CC denotes and
T3282 2728-2733 NN denotes C57BL
T3283 2733-2734 HYPH denotes /
T3284 2734-2735 CD denotes 6
T3280 2736-2740 NNS denotes mice
T3285 2740-2742 , denotes ,
T3286 2742-2748 RB denotes widely
T3287 2749-2753 VBN denotes used
T3288 2754-2756 IN denotes in
T3289 2757-2760 DT denotes the
T3290 2761-2771 NN denotes generation
T3291 2772-2774 IN denotes of
T3292 2775-2779 NN denotes gene
T3294 2779-2780 HYPH denotes -
T3293 2780-2788 VBN denotes targeted
T3295 2789-2793 NNS denotes mice
T3296 2793-2795 , denotes ,
T3275 2795-2798 VBP denotes are
T3297 2799-2812 RB denotes spontaneously
T3298 2813-2824 VBN denotes predisposed
T3299 2825-2827 IN denotes to
T3300 2828-2839 NN denotes development
T3301 2840-2842 IN denotes of
T3302 2843-2850 JJ denotes humoral
T3303 2851-2863 NN denotes autoimmunity
T3304 2864-2868 IN denotes with
T3305 2869-2872 JJ denotes low
T3306 2873-2879 NNS denotes levels
T3307 2880-2882 IN denotes of
T3308 2883-2901 NN denotes glomerulonephritis
T3309 2902-2903 -LRB- denotes (
T3310 2903-2908 NNP denotes Obata
T3311 2909-2911 FW denotes et
T3312 2912-2915 FW denotes al.
T3313 2916-2920 CD denotes 1979
T3314 2920-2921 : denotes ;
T3315 2922-2927 NNP denotes Botto
T3316 2928-2930 FW denotes et
T3317 2931-2934 FW denotes al.
T3318 2935-2939 CD denotes 1998
T3319 2939-2940 : denotes ;
T3320 2941-2952 NNP denotes Bickerstaff
T3321 2953-2955 FW denotes et
T3322 2956-2959 FW denotes al.
T3323 2960-2964 CD denotes 1999
T3324 2964-2965 : denotes ;
T3325 2966-2974 NNP denotes Santiago
T3326 2974-2975 HYPH denotes -
T3327 2975-2980 NNP denotes Raber
T3328 2981-2983 FW denotes et
T3329 2984-2987 FW denotes al.
T3330 2988-2992 CD denotes 2001
T3331 2992-2993 -RRB- denotes )
T3332 2993-2994 . denotes .
T3333 2994-3175 sentence denotes Furthermore, the genetic background markedly influences the autoimmune phenotype in gene-targeted mice (Bolland and Ravetch 2000; Santiago-Raber et al. 2001; Mitchell et al. 2002).
T3334 2995-3006 RB denotes Furthermore
T3336 3006-3008 , denotes ,
T3337 3008-3011 DT denotes the
T3339 3012-3019 JJ denotes genetic
T3338 3020-3030 NN denotes background
T3340 3031-3039 RB denotes markedly
T3335 3040-3050 VBZ denotes influences
T3341 3051-3054 DT denotes the
T3343 3055-3065 JJ denotes autoimmune
T3342 3066-3075 NN denotes phenotype
T3344 3076-3078 IN denotes in
T3345 3079-3083 NN denotes gene
T3347 3083-3084 HYPH denotes -
T3346 3084-3092 VBN denotes targeted
T3348 3093-3097 NNS denotes mice
T3349 3098-3099 -LRB- denotes (
T3350 3099-3106 NNP denotes Bolland
T3351 3107-3110 CC denotes and
T3352 3111-3118 NNP denotes Ravetch
T3353 3119-3123 CD denotes 2000
T3354 3123-3124 : denotes ;
T3355 3125-3133 NNP denotes Santiago
T3356 3133-3134 HYPH denotes -
T3357 3134-3139 NNP denotes Raber
T3358 3140-3142 FW denotes et
T3359 3143-3146 FW denotes al.
T3360 3147-3151 CD denotes 2001
T3361 3151-3152 : denotes ;
T3362 3153-3161 NNP denotes Mitchell
T3363 3162-3164 FW denotes et
T3364 3165-3168 FW denotes al.
T3365 3169-3173 CD denotes 2002
T3366 3173-3174 -RRB- denotes )
T3367 3174-3175 . denotes .
T3368 3175-3457 sentence denotes These observations led to the hypothesis that the autoimmune phenotype described in some gene-targeted mice might be due primarily to combinations of as-yet-uncharacterised background genes, originating from 129 and C57BL/6 mice strains, interacting or not with the mutated allele.
T3369 3176-3181 DT denotes These
T3370 3182-3194 NNS denotes observations
T3371 3195-3198 VBD denotes led
T3372 3199-3201 IN denotes to
T3373 3202-3205 DT denotes the
T3374 3206-3216 NN denotes hypothesis
T3375 3217-3221 IN denotes that
T3377 3222-3225 DT denotes the
T3379 3226-3236 JJ denotes autoimmune
T3378 3237-3246 NN denotes phenotype
T3380 3247-3256 VBN denotes described
T3381 3257-3259 IN denotes in
T3382 3260-3264 DT denotes some
T3384 3265-3269 NN denotes gene
T3386 3269-3270 HYPH denotes -
T3385 3270-3278 VBN denotes targeted
T3383 3279-3283 NNS denotes mice
T3387 3284-3289 MD denotes might
T3376 3290-3292 VB denotes be
T3388 3293-3296 IN denotes due
T3389 3297-3306 RB denotes primarily
T3390 3307-3309 IN denotes to
T3391 3310-3322 NNS denotes combinations
T3392 3323-3325 IN denotes of
T3393 3326-3328 RB denotes as
T3395 3328-3329 HYPH denotes -
T3394 3329-3332 RB denotes yet
T3397 3332-3333 HYPH denotes -
T3396 3333-3348 JJ denotes uncharacterised
T3399 3349-3359 NN denotes background
T3398 3360-3365 NNS denotes genes
T3400 3365-3367 , denotes ,
T3401 3367-3378 VBG denotes originating
T3402 3379-3383 IN denotes from
T3403 3384-3387 CD denotes 129
T3405 3388-3391 CC denotes and
T3406 3392-3397 NN denotes C57BL
T3407 3397-3398 HYPH denotes /
T3408 3398-3399 CD denotes 6
T3409 3400-3404 NNS denotes mice
T3404 3405-3412 NNS denotes strains
T3410 3412-3414 , denotes ,
T3411 3414-3425 VBG denotes interacting
T3412 3426-3428 CC denotes or
T3413 3429-3432 RB denotes not
T3414 3433-3437 IN denotes with
T3415 3438-3441 DT denotes the
T3417 3442-3449 VBN denotes mutated
T3416 3450-3456 NN denotes allele
T3418 3456-3457 . denotes .
T3419 3457-3638 sentence denotes To test this, we conducted a genome-wide scan analysis of two large cohorts of (129 × C57BL/6)F2 mice, one of which carried a mutation in the serum amyloid P component gene (Apcs).
T3420 3458-3460 TO denotes To
T3421 3461-3465 VB denotes test
T3423 3466-3470 DT denotes this
T3424 3470-3472 , denotes ,
T3425 3472-3474 PRP denotes we
T3422 3475-3484 VBD denotes conducted
T3426 3485-3486 DT denotes a
T3428 3487-3493 NN denotes genome
T3430 3493-3494 HYPH denotes -
T3429 3494-3498 JJ denotes wide
T3431 3499-3503 NN denotes scan
T3427 3504-3512 NN denotes analysis
T3432 3513-3515 IN denotes of
T3433 3516-3519 CD denotes two
T3435 3520-3525 JJ denotes large
T3434 3526-3533 NNS denotes cohorts
T3436 3534-3536 IN denotes of
T3437 3537-3538 -LRB- denotes (
T3439 3538-3541 CD denotes 129
T3440 3542-3543 SYM denotes ×
T3441 3544-3549 NN denotes C57BL
T3442 3549-3550 HYPH denotes /
T3443 3550-3551 CD denotes 6
T3444 3551-3552 -RRB- denotes )
T3445 3552-3554 NN denotes F2
T3438 3555-3559 NNS denotes mice
T3446 3559-3561 , denotes ,
T3447 3561-3564 CD denotes one
T3449 3565-3567 IN denotes of
T3450 3568-3573 WDT denotes which
T3448 3574-3581 VBD denotes carried
T3451 3582-3583 DT denotes a
T3452 3584-3592 NN denotes mutation
T3453 3593-3595 IN denotes in
T3454 3596-3599 DT denotes the
T3456 3600-3605 NN denotes serum
T3458 3606-3613 NN denotes amyloid
T3459 3614-3615 NN denotes P
T3457 3616-3625 NN denotes component
T3455 3626-3630 NN denotes gene
T3460 3631-3632 -LRB- denotes (
T3461 3632-3636 NN denotes Apcs
T3462 3636-3637 -RRB- denotes )
T3463 3637-3638 . denotes .
T3464 3638-3947 sentence denotes The Apcs-deficient mice (Apcs −/−) were chosen as an example of a gene-targeted strain previously reported to develop a lupus-like disease on the hybrid genetic background (129 × C57BL/6); autoimmunity in Apcs −/− mice persists even after backcrossing the mutated gene onto C57BL/6 (Bickerstaff et al. 1999).
T3465 3639-3642 DT denotes The
T3467 3643-3647 NN denotes Apcs
T3469 3647-3648 HYPH denotes -
T3468 3648-3657 JJ denotes deficient
T3466 3658-3662 NNS denotes mice
T3471 3663-3664 -LRB- denotes (
T3472 3664-3668 NN denotes Apcs
T3473 3669-3670 SYM denotes −
T3474 3670-3671 HYPH denotes /
T3475 3671-3672 SYM denotes −
T3476 3672-3673 -RRB- denotes )
T3477 3674-3678 VBD denotes were
T3470 3679-3685 VBN denotes chosen
T3479 3686-3688 IN denotes as
T3480 3689-3691 DT denotes an
T3481 3692-3699 NN denotes example
T3482 3700-3702 IN denotes of
T3483 3703-3704 DT denotes a
T3485 3705-3709 NN denotes gene
T3487 3709-3710 HYPH denotes -
T3486 3710-3718 VBN denotes targeted
T3484 3719-3725 NN denotes strain
T3488 3726-3736 RB denotes previously
T3489 3737-3745 VBN denotes reported
T3490 3746-3748 TO denotes to
T3491 3749-3756 VB denotes develop
T3492 3757-3758 DT denotes a
T3494 3759-3764 NN denotes lupus
T3496 3764-3765 HYPH denotes -
T3495 3765-3769 JJ denotes like
T3493 3770-3777 NN denotes disease
T3497 3778-3780 IN denotes on
T3498 3781-3784 DT denotes the
T3500 3785-3791 NN denotes hybrid
T3501 3792-3799 JJ denotes genetic
T3502 3800-3810 NN denotes background
T3503 3811-3812 -LRB- denotes (
T3504 3812-3815 CD denotes 129
T3505 3816-3817 SYM denotes ×
T3499 3818-3823 NN denotes C57BL
T3506 3823-3824 HYPH denotes /
T3507 3824-3825 CD denotes 6
T3508 3825-3826 -RRB- denotes )
T3509 3826-3827 : denotes ;
T3510 3828-3840 NN denotes autoimmunity
T3511 3841-3843 IN denotes in
T3512 3844-3848 NN denotes Apcs
T3514 3849-3850 SYM denotes −
T3515 3850-3851 HYPH denotes /
T3516 3851-3852 SYM denotes −
T3513 3853-3857 NNS denotes mice
T3478 3858-3866 VBZ denotes persists
T3517 3867-3871 RB denotes even
T3518 3872-3877 IN denotes after
T3519 3878-3890 VBG denotes backcrossing
T3520 3891-3894 DT denotes the
T3522 3895-3902 VBN denotes mutated
T3521 3903-3907 NN denotes gene
T3523 3908-3912 IN denotes onto
T3524 3913-3918 NN denotes C57BL
T3525 3918-3919 HYPH denotes /
T3526 3919-3920 CD denotes 6
T3527 3921-3922 -LRB- denotes (
T3528 3922-3933 NNP denotes Bickerstaff
T3529 3934-3936 FW denotes et
T3530 3937-3940 FW denotes al.
T3531 3941-3945 CD denotes 1999
T3532 3945-3946 -RRB- denotes )
T3533 3946-3947 . denotes .
T3534 3947-4352 sentence denotes We chose this targeted gene in particular to study since the Apcs gene is located on Chromosome 1, approximately 94 cM from the centromere, within a region where several lupus-susceptibility loci, designated Sle1 (Morel et al. 2001), Nba2 (Drake et al. 1995; Vyse et al. 1997), and Bxs3 (Hogarth et al. 1998; Haywood et al. 2000), have been mapped in NZW, NZB, and BXSB lupus-prone strains, respectively.
T3535 3948-3950 PRP denotes We
T3536 3951-3956 VBD denotes chose
T3537 3957-3961 DT denotes this
T3539 3962-3970 VBN denotes targeted
T3538 3971-3975 NN denotes gene
T3540 3976-3978 IN denotes in
T3541 3979-3989 JJ denotes particular
T3542 3990-3992 TO denotes to
T3543 3993-3998 VB denotes study
T3544 3999-4004 IN denotes since
T3546 4005-4008 DT denotes the
T3548 4009-4013 NN denotes Apcs
T3547 4014-4018 NN denotes gene
T3549 4019-4021 VBZ denotes is
T3545 4022-4029 VBN denotes located
T3550 4030-4032 IN denotes on
T3551 4033-4043 NN denotes Chromosome
T3552 4044-4045 CD denotes 1
T3553 4045-4047 , denotes ,
T3554 4047-4060 RB denotes approximately
T3555 4061-4063 CD denotes 94
T3556 4064-4066 NN denotes cM
T3557 4067-4071 IN denotes from
T3558 4072-4075 DT denotes the
T3559 4076-4086 NN denotes centromere
T3560 4086-4088 , denotes ,
T3561 4088-4094 IN denotes within
T3562 4095-4096 DT denotes a
T3563 4097-4103 NN denotes region
T3564 4104-4109 WRB denotes where
T3566 4110-4117 JJ denotes several
T3568 4118-4123 NN denotes lupus
T3570 4123-4124 HYPH denotes -
T3569 4124-4138 NN denotes susceptibility
T3567 4139-4143 NNS denotes loci
T3571 4143-4145 , denotes ,
T3572 4145-4155 VBN denotes designated
T3573 4156-4160 NN denotes Sle1
T3574 4161-4162 -LRB- denotes (
T3575 4162-4167 NNP denotes Morel
T3576 4168-4170 FW denotes et
T3577 4171-4174 FW denotes al.
T3578 4175-4179 CD denotes 2001
T3579 4179-4180 -RRB- denotes )
T3580 4180-4182 , denotes ,
T3581 4182-4186 NN denotes Nba2
T3582 4187-4188 -LRB- denotes (
T3583 4188-4193 NNP denotes Drake
T3584 4194-4196 FW denotes et
T3585 4197-4200 FW denotes al.
T3586 4201-4205 CD denotes 1995
T3587 4205-4206 : denotes ;
T3588 4207-4211 NNP denotes Vyse
T3589 4212-4214 FW denotes et
T3590 4215-4218 FW denotes al.
T3591 4219-4223 CD denotes 1997
T3592 4223-4224 -RRB- denotes )
T3593 4224-4226 , denotes ,
T3594 4226-4229 CC denotes and
T3595 4230-4234 NN denotes Bxs3
T3596 4235-4236 -LRB- denotes (
T3597 4236-4243 NNP denotes Hogarth
T3598 4244-4246 FW denotes et
T3599 4247-4250 FW denotes al.
T3600 4251-4255 CD denotes 1998
T3601 4255-4256 : denotes ;
T3602 4257-4264 NNP denotes Haywood
T3603 4265-4267 FW denotes et
T3604 4268-4271 FW denotes al.
T3605 4272-4276 CD denotes 2000
T3606 4276-4277 -RRB- denotes )
T3607 4277-4279 , denotes ,
T3608 4279-4283 VBP denotes have
T3609 4284-4288 VBN denotes been
T3565 4289-4295 VBN denotes mapped
T3610 4296-4298 IN denotes in
T3611 4299-4302 NN denotes NZW
T3613 4302-4304 , denotes ,
T3614 4304-4307 NN denotes NZB
T3615 4307-4309 , denotes ,
T3616 4309-4312 CC denotes and
T3617 4313-4317 NN denotes BXSB
T3618 4318-4323 NN denotes lupus
T3620 4323-4324 HYPH denotes -
T3619 4324-4329 JJ denotes prone
T3612 4330-4337 NNS denotes strains
T3621 4337-4339 , denotes ,
T3622 4339-4351 RB denotes respectively
T3623 4351-4352 . denotes .
T3624 4352-4706 sentence denotes This region contains several genes, including those encoding FcγRII, the complement receptor CR1/2 (CD35/CD21), and the decay-accelerating factor CD55 (Prodeus et al. 1998; Bolland and Ravetch 2000; Miwa et al. 2002; Wu et al. 2002), which have each been implicated in the causation of SLE when inactivated by gene-targeting in 129 embryonic stem cells.
T3625 4353-4357 DT denotes This
T3626 4358-4364 NN denotes region
T3627 4365-4373 VBZ denotes contains
T3628 4374-4381 JJ denotes several
T3629 4382-4387 NNS denotes genes
T3630 4387-4389 , denotes ,
T3631 4389-4398 VBG denotes including
T3632 4399-4404 DT denotes those
T3633 4405-4413 VBG denotes encoding
T3634 4414-4420 NN denotes FcγRII
T3635 4420-4422 , denotes ,
T3636 4422-4425 DT denotes the
T3638 4426-4436 NN denotes complement
T3637 4437-4445 NN denotes receptor
T3639 4446-4449 NN denotes CR1
T3640 4449-4450 HYPH denotes /
T3641 4450-4451 CD denotes 2
T3642 4452-4453 -LRB- denotes (
T3643 4453-4457 NN denotes CD35
T3645 4457-4458 HYPH denotes /
T3644 4458-4462 NN denotes CD21
T3646 4462-4463 -RRB- denotes )
T3647 4463-4465 , denotes ,
T3648 4465-4468 CC denotes and
T3649 4469-4472 DT denotes the
T3651 4473-4478 NN denotes decay
T3653 4478-4479 HYPH denotes -
T3652 4479-4491 VBG denotes accelerating
T3654 4492-4498 NN denotes factor
T3650 4499-4503 NN denotes CD55
T3655 4504-4505 -LRB- denotes (
T3656 4505-4512 NNP denotes Prodeus
T3657 4513-4515 FW denotes et
T3658 4516-4519 FW denotes al.
T3659 4520-4524 CD denotes 1998
T3660 4524-4525 : denotes ;
T3661 4526-4533 NNP denotes Bolland
T3662 4534-4537 CC denotes and
T3663 4538-4545 NNP denotes Ravetch
T3664 4546-4550 CD denotes 2000
T3665 4550-4551 : denotes ;
T3666 4552-4556 NNP denotes Miwa
T3667 4557-4559 FW denotes et
T3668 4560-4563 FW denotes al.
T3669 4564-4568 CD denotes 2002
T3670 4568-4569 : denotes ;
T3671 4570-4572 NNP denotes Wu
T3672 4573-4575 FW denotes et
T3673 4576-4579 FW denotes al.
T3674 4580-4584 CD denotes 2002
T3675 4584-4585 -RRB- denotes )
T3676 4585-4587 , denotes ,
T3677 4587-4592 WDT denotes which
T3679 4593-4597 VBP denotes have
T3680 4598-4602 DT denotes each
T3681 4603-4607 VBN denotes been
T3678 4608-4618 VBN denotes implicated
T3682 4619-4621 IN denotes in
T3683 4622-4625 DT denotes the
T3684 4626-4635 NN denotes causation
T3685 4636-4638 IN denotes of
T3686 4639-4642 NN denotes SLE
T3687 4643-4647 WRB denotes when
T3688 4648-4659 VBN denotes inactivated
T3689 4660-4662 IN denotes by
T3690 4663-4667 NN denotes gene
T3691 4667-4668 HYPH denotes -
T3692 4668-4677 VBG denotes targeting
T3693 4678-4680 IN denotes in
T3694 4681-4684 CD denotes 129
T3696 4685-4694 JJ denotes embryonic
T3697 4695-4699 NN denotes stem
T3695 4700-4705 NNS denotes cells
T3698 4705-4706 . denotes .
T3699 4706-4827 sentence denotes Here we show that there are multiple genetic loci, derived from both 129 and C57BL/6 mice, contributing to autoimmunity.
T3700 4707-4711 RB denotes Here
T3702 4712-4714 PRP denotes we
T3701 4715-4719 VBP denotes show
T3703 4720-4724 IN denotes that
T3705 4725-4730 EX denotes there
T3704 4731-4734 VBP denotes are
T3706 4735-4743 JJ denotes multiple
T3708 4744-4751 JJ denotes genetic
T3707 4752-4756 NNS denotes loci
T3709 4756-4758 , denotes ,
T3710 4758-4765 VBN denotes derived
T3711 4766-4770 IN denotes from
T3712 4771-4775 CC denotes both
T3713 4776-4779 CD denotes 129
T3715 4780-4783 CC denotes and
T3716 4784-4789 NN denotes C57BL
T3717 4789-4790 HYPH denotes /
T3718 4790-4791 CD denotes 6
T3714 4792-4796 NNS denotes mice
T3719 4796-4798 , denotes ,
T3720 4798-4810 VBG denotes contributing
T3721 4811-4813 IN denotes to
T3722 4814-4826 NN denotes autoimmunity
T3723 4826-4827 . denotes .
T3724 4827-5169 sentence denotes Furthermore, a 129-derived interval on distal Chromosome 1, when transferred onto the C57BL/6 genome, a combination commonly created by backcrossing onto C57BL/6 a gene that has been inactivated in 129 embryonic stem cells, was sufficient to cause humoral autoimmunity in its own right, irrespective of the presence of the mutated Apcs gene.
T3725 4828-4839 RB denotes Furthermore
T3727 4839-4841 , denotes ,
T3728 4841-4842 DT denotes a
T3730 4843-4846 CD denotes 129
T3732 4846-4847 HYPH denotes -
T3731 4847-4854 VBN denotes derived
T3729 4855-4863 NN denotes interval
T3733 4864-4866 IN denotes on
T3734 4867-4873 JJ denotes distal
T3735 4874-4884 NN denotes Chromosome
T3736 4885-4886 CD denotes 1
T3737 4886-4888 , denotes ,
T3738 4888-4892 WRB denotes when
T3739 4893-4904 VBN denotes transferred
T3740 4905-4909 IN denotes onto
T3741 4910-4913 DT denotes the
T3743 4914-4919 NN denotes C57BL
T3744 4919-4920 HYPH denotes /
T3745 4920-4921 CD denotes 6
T3742 4922-4928 NN denotes genome
T3746 4928-4930 , denotes ,
T3747 4930-4931 DT denotes a
T3748 4932-4943 NN denotes combination
T3749 4944-4952 RB denotes commonly
T3750 4953-4960 VBN denotes created
T3751 4961-4963 IN denotes by
T3752 4964-4976 VBG denotes backcrossing
T3753 4977-4981 IN denotes onto
T3754 4982-4987 NN denotes C57BL
T3755 4987-4988 HYPH denotes /
T3756 4988-4989 CD denotes 6
T3757 4990-4991 DT denotes a
T3758 4992-4996 NN denotes gene
T3759 4997-5001 WDT denotes that
T3761 5002-5005 VBZ denotes has
T3762 5006-5010 VBN denotes been
T3760 5011-5022 VBN denotes inactivated
T3763 5023-5025 IN denotes in
T3764 5026-5029 CD denotes 129
T3766 5030-5039 JJ denotes embryonic
T3767 5040-5044 NN denotes stem
T3765 5045-5050 NNS denotes cells
T3768 5050-5052 , denotes ,
T3726 5052-5055 VBD denotes was
T3769 5056-5066 JJ denotes sufficient
T3770 5067-5069 TO denotes to
T3771 5070-5075 VB denotes cause
T3772 5076-5083 JJ denotes humoral
T3773 5084-5096 NN denotes autoimmunity
T3774 5097-5099 IN denotes in
T3775 5100-5103 PRP$ denotes its
T3777 5104-5107 JJ denotes own
T3776 5108-5113 NN denotes right
T3778 5113-5115 , denotes ,
T3779 5115-5127 RB denotes irrespective
T3780 5128-5130 IN denotes of
T3781 5131-5134 DT denotes the
T3782 5135-5143 NN denotes presence
T3783 5144-5146 IN denotes of
T3784 5147-5150 DT denotes the
T3786 5151-5158 VBN denotes mutated
T3787 5159-5163 NN denotes Apcs
T3785 5164-5168 NN denotes gene
T3788 5168-5169 . denotes .
T3789 5169-5469 sentence denotes These results demonstrate important epistatic interactions between genes from 129 and C57BL/6 genomes on the development of autoimmunity and illustrate the important effects of background genes in the analysis and interpretation of autoimmune phenotypes associated with targeted genetic disruptions.
T3790 5170-5175 DT denotes These
T3791 5176-5183 NNS denotes results
T3792 5184-5195 VBP denotes demonstrate
T3793 5196-5205 JJ denotes important
T3795 5206-5215 JJ denotes epistatic
T3794 5216-5228 NNS denotes interactions
T3796 5229-5236 IN denotes between
T3797 5237-5242 NNS denotes genes
T3798 5243-5247 IN denotes from
T3799 5248-5251 CD denotes 129
T3801 5252-5255 CC denotes and
T3802 5256-5261 NN denotes C57BL
T3803 5261-5262 HYPH denotes /
T3804 5262-5263 CD denotes 6
T3800 5264-5271 NNS denotes genomes
T3805 5272-5274 IN denotes on
T3806 5275-5278 DT denotes the
T3807 5279-5290 NN denotes development
T3808 5291-5293 IN denotes of
T3809 5294-5306 NN denotes autoimmunity
T3810 5307-5310 CC denotes and
T3811 5311-5321 VBP denotes illustrate
T3812 5322-5325 DT denotes the
T3814 5326-5335 JJ denotes important
T3813 5336-5343 NNS denotes effects
T3815 5344-5346 IN denotes of
T3816 5347-5357 NN denotes background
T3817 5358-5363 NNS denotes genes
T3818 5364-5366 IN denotes in
T3819 5367-5370 DT denotes the
T3820 5371-5379 NN denotes analysis
T3821 5380-5383 CC denotes and
T3822 5384-5398 NN denotes interpretation
T3823 5399-5401 IN denotes of
T3824 5402-5412 JJ denotes autoimmune
T3825 5413-5423 NNS denotes phenotypes
T3826 5424-5434 VBN denotes associated
T3827 5435-5439 IN denotes with
T3828 5440-5448 VBN denotes targeted
T3830 5449-5456 JJ denotes genetic
T3829 5457-5468 NNS denotes disruptions
T3831 5468-5469 . denotes .
R1000 T3559 T3557 pobj centromere,from
R1001 T3577 T3575 nmod al.,Morel
R1002 T3578 T3575 nummod 2001,Morel
R1003 T3579 T3575 punct ),Morel
R1004 T3580 T3573 punct ", ",Sle1
R1005 T3665 T3663 punct ;,Ravetch
R1006 T3666 T3663 conj Miwa,Ravetch
R1007 T3581 T3573 conj Nba2,Sle1
R1008 T3667 T3666 nmod et,Miwa
R1009 T3582 T3583 punct (,Drake
R1010 T3668 T3666 nmod al.,Miwa
R1011 T3669 T3666 nummod 2002,Miwa
R1012 T3670 T3666 punct ;,Miwa
R1013 T3583 T3581 meta Drake,Nba2
R1014 T3671 T3666 conj Wu,Miwa
R1015 T3672 T3671 nmod et,Wu
R1016 T3584 T3583 nmod et,Drake
R1017 T3673 T3671 nmod al.,Wu
R1018 T3674 T3671 nummod 2002,Wu
R1019 T3675 T3671 punct ),Wu
R1020 T3585 T3583 nmod al.,Drake
R1021 T3676 T3637 punct ", ",receptor
R1022 T3677 T3678 dep which,implicated
R1023 T3586 T3583 nummod 1995,Drake
R1024 T3678 T3637 relcl implicated,receptor
R1025 T3679 T3678 aux have,implicated
R1026 T3680 T3678 npadvmod each,implicated
R1027 T3681 T3678 auxpass been,implicated
R1028 T3587 T3583 punct ;,Drake
R1029 T3682 T3678 prep in,implicated
R1030 T3683 T3684 det the,causation
R1031 T3588 T3583 nmod Vyse,Drake
R1032 T3684 T3682 pobj causation,in
R1033 T3685 T3684 prep of,causation
R1034 T3686 T3685 pobj SLE,of
R1035 T3589 T3583 nmod et,Drake
R1036 T3687 T3688 advmod when,inactivated
R1037 T3688 T3678 advcl inactivated,implicated
R1038 T3689 T3688 prep by,inactivated
R1039 T3590 T3583 nmod al.,Drake
R1040 T3690 T3689 pobj gene,by
R1041 T3691 T3690 punct -,gene
R1042 T3692 T3690 amod targeting,gene
R1043 T3693 T3688 prep in,inactivated
R1044 T3694 T3695 nummod 129,cells
R1045 T3591 T3583 nummod 1997,Drake
R1046 T3695 T3693 pobj cells,in
R1047 T3696 T3695 amod embryonic,cells
R1048 T3697 T3695 compound stem,cells
R1049 T3698 T3627 punct .,contains
R1050 T3592 T3583 punct ),Drake
R1051 T3593 T3581 punct ", ",Nba2
R1052 T3700 T3701 advmod Here,show
R1053 T3702 T3701 nsubj we,show
R1054 T3594 T3581 cc and,Nba2
R1055 T3703 T3704 mark that,are
R1056 T3704 T3701 ccomp are,show
R1057 T3705 T3704 expl there,are
R1058 T3595 T3581 conj Bxs3,Nba2
R1059 T3706 T3707 amod multiple,loci
R1060 T3707 T3704 attr loci,are
R1061 T3708 T3707 amod genetic,loci
R1062 T3596 T3597 punct (,Hogarth
R1063 T3709 T3707 punct ", ",loci
R1064 T3710 T3707 acl derived,loci
R1065 T3711 T3710 prep from,derived
R1066 T3597 T3595 meta Hogarth,Bxs3
R1067 T3712 T3713 preconj both,129
R1068 T3713 T3714 nummod 129,mice
R1069 T3714 T3711 pobj mice,from
R1070 T3598 T3597 nmod et,Hogarth
R1071 T3715 T3713 cc and,129
R1072 T3716 T3713 conj C57BL,129
R1073 T3717 T3716 punct /,C57BL
R1074 T3599 T3597 nmod al.,Hogarth
R1075 T3718 T3716 nummod 6,C57BL
R1076 T3719 T3707 punct ", ",loci
R1077 T3720 T3707 acl contributing,loci
R1078 T3600 T3597 nummod 1998,Hogarth
R1079 T3721 T3720 prep to,contributing
R1080 T3722 T3721 pobj autoimmunity,to
R1081 T3601 T3597 punct ;,Hogarth
R1082 T3723 T3701 punct .,show
R1083 T3725 T3726 advmod Furthermore,was
R1084 T3602 T3597 nmod Haywood,Hogarth
R1085 T3727 T3726 punct ", ",was
R1086 T3728 T3729 det a,interval
R1087 T3603 T3597 nmod et,Hogarth
R1088 T3729 T3726 nsubj interval,was
R1089 T3730 T3731 advmod 129,derived
R1090 T3604 T3597 nmod al.,Hogarth
R1091 T3731 T3729 amod derived,interval
R1092 T3732 T3731 punct -,derived
R1093 T3733 T3729 prep on,interval
R1094 T3734 T3735 amod distal,Chromosome
R1095 T3735 T3733 pobj Chromosome,on
R1096 T3736 T3735 nummod 1,Chromosome
R1097 T3605 T3597 nummod 2000,Hogarth
R1098 T3737 T3726 punct ", ",was
R1099 T3738 T3739 advmod when,transferred
R1100 T3739 T3726 advcl transferred,was
R1101 T3606 T3597 punct ),Hogarth
R1102 T3740 T3739 prep onto,transferred
R1103 T3741 T3742 det the,genome
R1104 T3607 T3565 punct ", ",mapped
R1105 T3608 T3565 aux have,mapped
R1106 T3742 T3740 pobj genome,onto
R1107 T3609 T3565 auxpass been,mapped
R1108 T3743 T3742 nmod C57BL,genome
R1109 T3744 T3743 punct /,C57BL
R1110 T3610 T3565 prep in,mapped
R1111 T3745 T3743 nummod 6,C57BL
R1112 T3746 T3742 punct ", ",genome
R1113 T3747 T3748 det a,combination
R1114 T3611 T3612 nmod NZW,strains
R1115 T3748 T3742 appos combination,genome
R1116 T3749 T3750 advmod commonly,created
R1117 T3750 T3748 acl created,combination
R1118 T3612 T3610 pobj strains,in
R1119 T3751 T3750 prep by,created
R1120 T3613 T3611 punct ", ",NZW
R1121 T3752 T3751 pcomp backcrossing,by
R1122 T3753 T3752 prep onto,backcrossing
R1123 T3754 T3753 pobj C57BL,onto
R1124 T3614 T3611 conj NZB,NZW
R1125 T3755 T3754 punct /,C57BL
R1126 T3756 T3754 nummod 6,C57BL
R1127 T3757 T3758 det a,gene
R1128 T3615 T3614 punct ", ",NZB
R1129 T3758 T3752 dobj gene,backcrossing
R1130 T3759 T3760 dep that,inactivated
R1131 T3616 T3614 cc and,NZB
R1132 T3760 T3758 relcl inactivated,gene
R1133 T3761 T3760 aux has,inactivated
R1134 T3762 T3760 auxpass been,inactivated
R1135 T3617 T3614 conj BXSB,NZB
R1136 T3763 T3760 prep in,inactivated
R1137 T3764 T3765 nummod 129,cells
R1138 T3765 T3763 pobj cells,in
R1139 T3618 T3619 npadvmod lupus,prone
R1140 T3766 T3765 amod embryonic,cells
R1141 T3767 T3765 compound stem,cells
R1142 T3768 T3726 punct ", ",was
R1143 T3619 T3612 amod prone,strains
R1144 T3769 T3726 acomp sufficient,was
R1145 T3770 T3771 aux to,cause
R1146 T3620 T3619 punct -,prone
R1147 T3771 T3769 xcomp cause,sufficient
R1148 T3772 T3773 amod humoral,autoimmunity
R1149 T3621 T3565 punct ", ",mapped
R1150 T3773 T3771 dobj autoimmunity,cause
R1151 T3774 T3771 prep in,cause
R1152 T3622 T3565 advmod respectively,mapped
R1153 T3775 T3776 poss its,right
R1154 T3776 T3774 pobj right,in
R1155 T3777 T3776 amod own,right
R1156 T3623 T3536 punct .,chose
R1157 T3778 T3771 punct ", ",cause
R1158 T3779 T3771 advmod irrespective,cause
R1159 T3780 T3779 prep of,irrespective
R1160 T3625 T3626 det This,region
R1161 T3781 T3782 det the,presence
R1162 T3782 T3780 pobj presence,of
R1163 T3783 T3782 prep of,presence
R1164 T3626 T3627 nsubj region,contains
R1165 T3784 T3785 det the,gene
R1166 T3785 T3783 pobj gene,of
R1167 T3786 T3785 amod mutated,gene
R1168 T3628 T3629 amod several,genes
R1169 T3787 T3785 compound Apcs,gene
R1170 T3788 T3726 punct .,was
R1171 T3790 T3791 det These,results
R1172 T3629 T3627 dobj genes,contains
R1173 T3791 T3792 nsubj results,demonstrate
R1174 T3630 T3629 punct ", ",genes
R1175 T3793 T3794 amod important,interactions
R1176 T3794 T3792 dobj interactions,demonstrate
R1177 T3795 T3794 amod epistatic,interactions
R1178 T3631 T3629 prep including,genes
R1179 T3796 T3794 prep between,interactions
R1180 T3797 T3796 pobj genes,between
R1181 T3798 T3797 prep from,genes
R1182 T3632 T3631 pobj those,including
R1183 T3799 T3800 nummod 129,genomes
R1184 T3800 T3798 pobj genomes,from
R1185 T3633 T3632 acl encoding,those
R1186 T3801 T3799 cc and,129
R1187 T3802 T3799 conj C57BL,129
R1188 T3803 T3802 punct /,C57BL
R1189 T3634 T3633 dobj FcγRII,encoding
R1190 T3804 T3802 nummod 6,C57BL
R1191 T3805 T3794 prep on,interactions
R1192 T3806 T3807 det the,development
R1193 T3807 T3805 pobj development,on
R1194 T3635 T3632 punct ", ",those
R1195 T3808 T3807 prep of,development
R1196 T3809 T3808 pobj autoimmunity,of
R1197 T3636 T3637 det the,receptor
R1198 T3810 T3792 cc and,demonstrate
R1199 T3811 T3792 conj illustrate,demonstrate
R1200 T3812 T3813 det the,effects
R1201 T3813 T3811 dobj effects,illustrate
R1202 T3814 T3813 amod important,effects
R1203 T3815 T3813 prep of,effects
R1204 T3637 T3632 appos receptor,those
R1205 T3816 T3817 compound background,genes
R1206 T3817 T3815 pobj genes,of
R1207 T3818 T3811 prep in,illustrate
R1208 T3819 T3820 det the,analysis
R1209 T3638 T3637 compound complement,receptor
R1210 T3820 T3818 pobj analysis,in
R1211 T3821 T3820 cc and,analysis
R1212 T3822 T3820 conj interpretation,analysis
R1213 T3639 T3637 appos CR1,receptor
R1214 T3823 T3820 prep of,analysis
R1215 T3824 T3825 amod autoimmune,phenotypes
R1216 T3640 T3639 punct /,CR1
R1217 T3825 T3823 pobj phenotypes,of
R1218 T3641 T3639 nummod 2,CR1
R1219 T3826 T3825 acl associated,phenotypes
R1220 T3642 T3639 punct (,CR1
R1221 T3827 T3826 prep with,associated
R1222 T3828 T3829 amod targeted,disruptions
R1223 T3643 T3644 compound CD35,CD21
R1224 T3829 T3827 pobj disruptions,with
R1225 T3644 T3639 appos CD21,CR1
R1226 T3830 T3829 amod genetic,disruptions
R1227 T3831 T3792 punct .,demonstrate
R1228 T3645 T3644 punct /,CD21
R1229 T3646 T3639 punct ),CR1
R1230 T3647 T3637 punct ", ",receptor
R1231 T3648 T3637 cc and,receptor
R1232 T3649 T3650 det the,CD55
R1233 T3650 T3637 conj CD55,receptor
R1234 T3651 T3652 npadvmod decay,accelerating
R1235 T3652 T3650 amod accelerating,CD55
R1236 T3653 T3652 punct -,accelerating
R1237 T3654 T3650 compound factor,CD55
R1238 T3655 T3656 punct (,Prodeus
R1239 T3656 T3650 meta Prodeus,CD55
R1240 T3657 T3656 nmod et,Prodeus
R1241 T3658 T3656 nmod al.,Prodeus
R1242 T3659 T3656 nummod 1998,Prodeus
R1243 T3660 T3656 punct ;,Prodeus
R1244 T3661 T3656 conj Bolland,Prodeus
R1245 T3662 T3661 cc and,Bolland
R1246 T3663 T3661 conj Ravetch,Bolland
R1247 T3664 T3663 nummod 2000,Ravetch
R263 T2804 T2805 amod Systemic,erythematosus
R264 T2805 T2807 nsubj erythematosus,is
R265 T2806 T2805 compound lupus,erythematosus
R266 T2808 T2805 punct (,erythematosus
R267 T2809 T2805 appos SLE,erythematosus
R268 T2810 T2805 punct ),erythematosus
R269 T2811 T2812 det a,disease
R270 T2812 T2807 attr disease,is
R271 T2813 T2812 amod chronic,disease
R272 T2814 T2812 amod autoimmune,disease
R273 T2815 T2812 acl characterised,disease
R274 T2816 T2815 agent by,characterised
R275 T2817 T2818 det the,production
R276 T2818 T2816 pobj production,by
R277 T2819 T2818 prep of,production
R278 T2820 T2819 pobj autoantibodies,of
R279 T2821 T2820 punct (,autoantibodies
R280 T2822 T2820 appos auto-Abs,autoantibodies
R281 T2823 T2820 punct ),autoantibodies
R282 T2824 T2818 prep against,production
R283 T2825 T2826 det a,spectrum
R284 T2826 T2824 pobj spectrum,against
R285 T2827 T2826 amod wide,spectrum
R286 T2828 T2826 prep of,spectrum
R287 T2829 T2830 compound self,antigens
R288 T2830 T2828 pobj antigens,of
R289 T2831 T2830 punct -,antigens
R290 T2832 T2830 punct ", ",antigens
R291 T2833 T2834 advmod mainly,from
R292 T2834 T2830 prep from,antigens
R293 T2835 T2836 amod subcellular,compartments
R294 T2836 T2834 pobj compartments,from
R295 T2837 T2836 punct ", ",compartments
R296 T2838 T2839 advmod especially,nucleus
R297 T2839 T2836 appos nucleus,compartments
R298 T2840 T2839 det the,nucleus
R299 T2841 T2839 compound cell,nucleus
R300 T2842 T2807 punct .,is
R301 T2925 T2924 pobj autoimmunity,of
R302 T2844 T2845 amod Genetic,predisposition
R303 T2926 T2922 acl generated,models
R304 T2845 T2846 nsubj predisposition,is
R305 T2927 T2926 prep by,generated
R306 T2928 T2929 amod targeted,disruption
R307 T2847 T2848 det an,contributor
R308 T2929 T2927 pobj disruption,by
R309 T2930 T2929 prep of,disruption
R310 T2931 T2932 amod specific,genes
R311 T2932 T2930 pobj genes,of
R312 T2933 T2932 acl modulating,genes
R313 T2934 T2935 det the,system
R314 T2935 T2933 dobj system,modulating
R315 T2936 T2935 amod immune,system
R316 T2937 T2906 aux have,used
R317 T2938 T2906 advmod widely,used
R318 T2939 T2906 auxpass been,used
R319 T2940 T2941 aux to,investigate
R320 T2848 T2846 attr contributor,is
R321 T2941 T2906 advcl investigate,used
R322 T2942 T2943 det the,complexity
R323 T2943 T2941 dobj complexity,investigate
R324 T2944 T2943 prep of,complexity
R325 T2849 T2848 amod important,contributor
R326 T2945 T2944 pobj SLE,of
R327 T2850 T2848 prep to,contributor
R328 T2946 T2906 punct .,used
R329 T2851 T2850 pobj susceptibility,to
R330 T2948 T2949 det The,strains
R331 T2852 T2851 prep to,susceptibility
R332 T2949 T2953 nsubj strains,are
R333 T2950 T2951 advmod best,studied
R334 T2951 T2949 amod studied,strains
R335 T2853 T2852 pobj SLE,to
R336 T2952 T2951 punct -,studied
R337 T2954 T2949 prep of,strains
R338 T2854 T2846 prep in,is
R339 T2955 T2954 pobj mice,of
R340 T2956 T2957 dep that,develop
R341 T2855 T2856 preconj both,humans
R342 T2957 T2955 relcl develop,mice
R343 T2958 T2957 advmod spontaneously,develop
R344 T2856 T2854 pobj humans,in
R345 T2959 T2960 det a,pathology
R346 T2960 T2957 dobj pathology,develop
R347 T2961 T2962 npadvmod lupus,like
R348 T2857 T2856 cc and,humans
R349 T2962 T2960 amod like,pathology
R350 T2963 T2962 punct -,like
R351 T2858 T2856 conj animals,humans
R352 T2964 T2965 det the,strain
R353 T2965 T2953 attr strain,are
R354 T2966 T2967 nmod New,Zealand
R355 T2859 T2860 punct (,Vyse
R356 T2967 T2968 nmod Zealand,Black
R357 T2968 T2965 nmod Black,strain
R358 T2969 T2968 punct /,Black
R359 T2860 T2846 meta Vyse,is
R360 T2970 T2971 compound New,Zealand
R361 T2971 T2972 compound Zealand,White
R362 T2972 T2968 appos White,Black
R363 T2973 T2965 compound hybrid,strain
R364 T2974 T2975 punct (,WF1
R365 T2975 T2965 parataxis WF1,strain
R366 T2976 T2975 compound NZB,WF1
R367 T2977 T2975 punct /,WF1
R368 T2861 T2860 cc and,Vyse
R369 T2978 T2975 punct ),WF1
R370 T2979 T2965 punct ;,strain
R371 T2980 T2981 det the,strain
R372 T2862 T2860 conj Todd,Vyse
R373 T2863 T2862 nummod 1996,Todd
R374 T2981 T2965 conj strain,strain
R375 T2864 T2862 punct ;,Todd
R376 T2982 T2983 compound MRL,Mp
R377 T2983 T2981 compound Mp,strain
R378 T2984 T2983 punct /,Mp
R379 T2865 T2862 conj Harley,Todd
R380 T2985 T2986 compound lpr,lpr
R381 T2986 T2981 compound lpr,strain
R382 T2987 T2986 punct /,lpr
R383 T2866 T2865 nmod et,Harley
R384 T2988 T2981 punct ", ",strain
R385 T2989 T2990 dep which,carries
R386 T2990 T2981 relcl carries,strain
R387 T2867 T2865 nmod al.,Harley
R388 T2991 T2992 det the,mutation
R389 T2868 T2865 nummod 1998,Harley
R390 T2992 T2990 dobj mutation,carries
R391 T2993 T2992 compound lpr,mutation
R392 T2994 T2992 prep of,mutation
R393 T2995 T2996 det the,gene
R394 T2869 T2865 punct ;,Harley
R395 T2870 T2865 conj Theofilopoulos,Harley
R396 T2996 T2994 pobj gene,of
R397 T2997 T2998 compound FAS,receptor
R398 T2998 T2996 compound receptor,gene
R399 T2999 T2981 punct ;,strain
R400 T2871 T2870 cc and,Theofilopoulos
R401 T3000 T2981 cc and,strain
R402 T3001 T3002 det the,strain
R403 T3002 T2981 conj strain,strain
R404 T2872 T2870 conj Kono,Theofilopoulos
R405 T3003 T3002 compound BXSB,strain
R406 T3004 T3002 punct ", ",strain
R407 T3005 T3006 dep which,carries
R408 T2873 T2872 nummod 1999,Kono
R409 T3006 T3002 relcl carries,strain
R410 T3007 T3008 det the,gene
R411 T3008 T3006 dobj gene,carries
R412 T2874 T2872 punct ;,Kono
R413 T3009 T3010 nmod Y,chromosome
R414 T3010 T3011 nmod chromosome,accelerator
R415 T3011 T3008 nmod accelerator,gene
R416 T3012 T3011 amod autoimmune,accelerator
R417 T3013 T3011 punct (,accelerator
R418 T3014 T3011 appos Yaa,accelerator
R419 T2875 T2872 conj Wakeland,Kono
R420 T3015 T3011 punct ),accelerator
R421 T3016 T3017 punct (,Theofilopoulos
R422 T3017 T3008 meta Theofilopoulos,gene
R423 T2876 T2875 nmod et,Wakeland
R424 T3018 T3017 cc and,Theofilopoulos
R425 T3019 T3017 conj Dixon,Theofilopoulos
R426 T3020 T3019 nummod 1985,Dixon
R427 T2877 T2875 nmod al.,Wakeland
R428 T3021 T3019 punct ),Dixon
R429 T3022 T2953 punct .,are
R430 T2878 T2875 nummod 2001,Wakeland
R431 T3024 T3025 amod Extensive,studies
R432 T3025 T3028 nsubj studies,identified
R433 T2879 T2875 punct ),Wakeland
R434 T3026 T3027 amod genetic,mapping
R435 T3027 T3025 compound mapping,studies
R436 T2880 T2846 punct .,is
R437 T3029 T3025 prep in,studies
R438 T3030 T3031 det all,strains
R439 T2882 T2883 nsubj Genes,participate
R440 T2884 T2882 prep in,Genes
R441 T2885 T2886 amod multiple,pathways
R442 T3031 T3029 pobj strains,in
R443 T3032 T3031 nummod three,strains
R444 T2886 T2884 pobj pathways,in
R445 T3033 T3028 aux have,identified
R446 T3034 T3035 amod multiple,intervals
R447 T2887 T2883 prep in,participate
R448 T3035 T3028 dobj intervals,identified
R449 T3036 T3035 acl associated,intervals
R450 T2888 T2887 pcomp mediating,in
R451 T3037 T3036 prep with,associated
R452 T3038 T3039 compound disease,susceptibility
R453 T3039 T3037 pobj susceptibility,with
R454 T2889 T2890 compound disease,pathogenesis
R455 T3040 T3028 punct .,identified
R456 T2890 T2888 dobj pathogenesis,mediating
R457 T3042 T3043 advmod Interestingly,are
R458 T3044 T3043 punct ", ",are
R459 T2891 T2883 punct ", ",participate
R460 T3045 T3046 det the,majority
R461 T3046 T3043 nsubj majority,are
R462 T3047 T3046 prep of,majority
R463 T2892 T2883 cc and,participate
R464 T3048 T3049 det the,intervals
R465 T3049 T3047 pobj intervals,of
R466 T2893 T2894 amod epistatic,interactions
R467 T3050 T3049 acl detected,intervals
R468 T3051 T3052 npadvmod strain,specific
R469 T3052 T3043 acomp specific,are
R470 T3053 T3052 punct -,specific
R471 T3054 T3043 punct ", ",are
R472 T3055 T3043 advcl confirming,are
R473 T2894 T2895 nsubj interactions,influence
R474 T3056 T3057 det the,complexity
R475 T3057 T3055 dobj complexity,confirming
R476 T3058 T3057 amod genetic,complexity
R477 T2895 T2883 conj influence,participate
R478 T3059 T3057 prep of,complexity
R479 T3060 T3061 det the,disease
R480 T3061 T3059 pobj disease,of
R481 T2896 T2894 prep amongst,interactions
R482 T3062 T3055 cc and,confirming
R483 T3063 T3055 conj indicating,confirming
R484 T3064 T3065 det the,presence
R485 T2897 T2898 det these,genes
R486 T3065 T3063 dobj presence,indicating
R487 T3066 T3065 prep of,presence
R488 T2898 T2896 pobj genes,amongst
R489 T2899 T2900 det the,expression
R490 T2900 T2895 dobj expression,influence
R491 T3067 T3068 amod extensive,heterogeneity
R492 T2901 T2900 prep of,expression
R493 T3068 T3066 pobj heterogeneity,of
R494 T3069 T3063 prep in,indicating
R495 T2902 T2901 pobj disease,of
R496 T3070 T3071 det the,genes
R497 T3071 T3069 pobj genes,in
R498 T2903 T2895 punct .,influence
R499 T3072 T3071 acl contributing,genes
R500 T3073 T3072 prep to,contributing
R501 T3074 T3075 det the,pathogenesis
R502 T2905 T2906 prep In,used
R503 T3075 T3073 pobj pathogenesis,to
R504 T3076 T3075 prep of,pathogenesis
R505 T3077 T3078 det the,disease
R506 T2907 T2908 det this,context
R507 T3078 T3076 pobj disease,of
R508 T3079 T3043 punct .,are
R509 T2908 T2905 pobj context,In
R510 T3081 T3082 advmod However,mapped
R511 T2909 T2906 punct ", ",used
R512 T3083 T3082 punct ", ",mapped
R513 T3084 T3085 det some,loci
R514 T3085 T3082 nsubjpass loci,mapped
R515 T2910 T2911 preconj both,studies
R516 T3086 T3085 compound susceptibility,loci
R517 T3087 T3082 aux have,mapped
R518 T2911 T2906 nsubjpass studies,used
R519 T3088 T3082 auxpass been,mapped
R520 T3089 T3082 prep to,mapped
R521 T3090 T3091 amod similar,locations
R522 T3091 T3089 pobj locations,to
R523 T3092 T3091 compound chromosome,locations
R524 T3093 T3091 prep in,locations
R525 T3094 T3095 amod different,strains
R526 T2912 T2913 amod genetic,linkage
R527 T3095 T3093 pobj strains,in
R528 T3096 T3082 punct ", ",mapped
R529 T3097 T3082 advcl suggesting,mapped
R530 T2913 T2911 compound linkage,studies
R531 T3098 T3099 mark that,shared
R532 T3099 T3097 ccomp shared,suggesting
R533 T3100 T3101 advmod at,least
R534 T2914 T2911 prep in,studies
R535 T3101 T3102 advmod least,susceptibility
R536 T3102 T3099 nsubjpass susceptibility,shared
R537 T3103 T3102 det some,susceptibility
R538 T2915 T2916 amod spontaneous,models
R539 T3104 T3099 aux may,shared
R540 T3105 T3099 auxpass be,shared
R541 T3106 T3099 prep amongst,shared
R542 T2916 T2914 pobj models,in
R543 T3107 T3108 npadvmod lupus,prone
R544 T3108 T3110 amod prone,strains
R545 T2917 T2918 npadvmod lupus,prone
R546 T3109 T3108 punct -,prone
R547 T3110 T3106 pobj strains,amongst
R548 T3111 T3082 punct .,mapped
R549 T2918 T2916 amod prone,models
R550 T3113 T3114 prep Amongst,are
R551 T2919 T2918 punct -,prone
R552 T3115 T3116 det these,loci
R553 T3116 T3113 pobj loci,Amongst
R554 T2920 T2911 cc and,studies
R555 T3117 T3116 amod shared,loci
R556 T3118 T3116 compound susceptibility,loci
R557 T3119 T3114 punct ", ",are
R558 T2921 T2922 amod synthetic,models
R559 T3120 T3121 det the,striking
R560 T3121 T3114 nsubj striking,are
R561 T2922 T2911 conj models,studies
R562 T3122 T3121 advmod most,striking
R563 T3123 T3114 attr loci,are
R564 T3124 T3123 prep on,loci
R565 T2923 T2922 amod murine,models
R566 T3125 T3126 amod distal,Chromosome
R567 T3126 T3124 pobj Chromosome,on
R568 T3127 T3126 nummod 1,Chromosome
R569 T2924 T2922 prep of,models
R570 T3128 T3123 punct ", ",loci
R571 T3129 T3130 prep for,found
R572 T3130 T3123 relcl found,loci
R573 T3131 T3129 pobj which,for
R574 T3132 T3133 amod important,genes
R575 T3137 T3130 prep in,found
R576 T3133 T3130 nsubjpass genes,found
R577 T3134 T3133 amod contributing,genes
R578 T3138 T3139 nmod New,Zealand
R579 T3135 T3130 aux have,found
R580 T3136 T3130 auxpass been,found
R581 T3139 T3140 nmod Zealand,models
R582 T3140 T3137 pobj models,in
R583 T3141 T3139 cc and,Zealand
R584 T3243 T3244 advmod most,surprising
R585 T3142 T3139 conj BXSB,Zealand
R586 T3244 T3242 amod surprising,result
R587 T3245 T3242 prep of,result
R588 T3143 T3144 punct (,Theofilopoulos
R589 T3246 T3247 det this,approach
R590 T3247 T3245 pobj approach,of
R591 T3144 T3130 meta Theofilopoulos,found
R592 T3248 T3247 amod powerful,approach
R593 T3249 T3239 aux has,been
R594 T3145 T3144 cc and,Theofilopoulos
R595 T3250 T3251 det the,frequency
R596 T3251 T3239 attr frequency,been
R597 T3252 T3251 amod high,frequency
R598 T3146 T3144 conj Kono,Theofilopoulos
R599 T3253 T3254 prep with,associated
R600 T3254 T3251 relcl associated,frequency
R601 T3255 T3253 pobj which,with
R602 T3147 T3146 nummod 1999,Kono
R603 T3256 T3257 amod such,mutations
R604 T3257 T3254 nsubjpass mutations,associated
R605 T3258 T3254 aux have,associated
R606 T3148 T3146 punct ;,Kono
R607 T3259 T3254 auxpass been,associated
R608 T3260 T3254 prep with,associated
R609 T3261 T3262 det an,phenotype
R610 T3149 T3146 conj Wakeland,Kono
R611 T3262 T3260 pobj phenotype,with
R612 T3263 T3262 amod autoimmune,phenotype
R613 T3264 T3239 punct .,been
R614 T3150 T3149 nmod et,Wakeland
R615 T3266 T3267 prep In,is
R616 T3151 T3149 nmod al.,Wakeland
R617 T3268 T3269 det this,regard
R618 T3269 T3266 pobj regard,In
R619 T3152 T3149 nummod 2001,Wakeland
R620 T3270 T3267 punct ", ",is
R621 T3271 T3267 nsubj it,is
R622 T3272 T3267 prep of,is
R623 T3153 T3149 punct ),Wakeland
R624 T3273 T3272 pobj note,of
R625 T3274 T3275 mark that,are
R626 T3275 T3267 ccomp are,is
R627 T3276 T3277 amod hybrid,strains
R628 T3277 T3275 nsubj strains,are
R629 T3278 T3277 prep between,strains
R630 T3154 T3114 punct .,are
R631 T3279 T3280 nummod 129,mice
R632 T3280 T3278 pobj mice,between
R633 T3281 T3279 cc and,129
R634 T3156 T3157 mark Although,made
R635 T3282 T3279 conj C57BL,129
R636 T3283 T3282 punct /,C57BL
R637 T3284 T3282 nummod 6,C57BL
R638 T3285 T3277 punct ", ",strains
R639 T3157 T3162 advcl made,resolved
R640 T3286 T3287 advmod widely,used
R641 T3287 T3277 acl used,strains
R642 T3288 T3287 prep in,used
R643 T3158 T3159 amod considerable,efforts
R644 T3289 T3290 det the,generation
R645 T3290 T3288 pobj generation,in
R646 T3291 T3290 prep of,generation
R647 T3159 T3157 nsubjpass efforts,made
R648 T3292 T3293 npadvmod gene,targeted
R649 T3293 T3295 amod targeted,mice
R650 T3294 T3293 punct -,targeted
R651 T3160 T3157 aux have,made
R652 T3295 T3291 pobj mice,of
R653 T3296 T3275 punct ", ",are
R654 T3297 T3275 advmod spontaneously,are
R655 T3161 T3157 auxpass been,made
R656 T3298 T3275 acomp predisposed,are
R657 T3299 T3298 prep to,predisposed
R658 T3163 T3164 aux to,identify
R659 T3300 T3299 pobj development,to
R660 T3301 T3300 prep of,development
R661 T3302 T3303 amod humoral,autoimmunity
R662 T3303 T3301 pobj autoimmunity,of
R663 T3304 T3303 prep with,autoimmunity
R664 T3305 T3306 amod low,levels
R665 T3164 T3157 xcomp identify,made
R666 T3306 T3304 pobj levels,with
R667 T3307 T3306 prep of,levels
R668 T3165 T3166 det the,genes
R669 T3308 T3307 pobj glomerulonephritis,of
R670 T3309 T3310 punct (,Obata
R671 T3310 T3275 meta Obata,are
R672 T3166 T3164 dobj genes,identify
R673 T3311 T3310 nmod et,Obata
R674 T3312 T3310 nmod al.,Obata
R675 T3313 T3310 nummod 1979,Obata
R676 T3314 T3310 punct ;,Obata
R677 T3315 T3310 nmod Botto,Obata
R678 T3316 T3310 nmod et,Obata
R679 T3317 T3310 nmod al.,Obata
R680 T3167 T3166 amod responsible,genes
R681 T3318 T3310 nummod 1998,Obata
R682 T3319 T3310 punct ;,Obata
R683 T3320 T3310 nmod Bickerstaff,Obata
R684 T3168 T3167 prep for,responsible
R685 T3321 T3310 nmod et,Obata
R686 T3169 T3170 det the,development
R687 T3322 T3310 nmod al.,Obata
R688 T3323 T3310 nummod 1999,Obata
R689 T3170 T3168 pobj development,for
R690 T3324 T3310 punct ;,Obata
R691 T3325 T3310 nmod Santiago,Obata
R692 T3171 T3170 prep of,development
R693 T3326 T3310 punct -,Obata
R694 T3327 T3310 nmod Raber,Obata
R695 T3328 T3310 nmod et,Obata
R696 T3172 T3173 det the,disease
R697 T3329 T3310 nmod al.,Obata
R698 T3330 T3310 nummod 2001,Obata
R699 T3331 T3310 punct ),Obata
R700 T3173 T3171 pobj disease,of
R701 T3332 T3267 punct .,is
R702 T3174 T3162 punct ", ",resolved
R703 T3334 T3335 advmod Furthermore,influences
R704 T3336 T3335 punct ", ",influences
R705 T3175 T3162 prep with,resolved
R706 T3337 T3338 det the,background
R707 T3338 T3335 nsubj background,influences
R708 T3176 T3177 det the,exception
R709 T3339 T3338 amod genetic,background
R710 T3340 T3335 advmod markedly,influences
R711 T3341 T3342 det the,phenotype
R712 T3177 T3175 pobj exception,with
R713 T3342 T3335 dobj phenotype,influences
R714 T3343 T3342 amod autoimmune,phenotype
R715 T3344 T3335 prep in,influences
R716 T3178 T3177 prep of,exception
R717 T3345 T3346 npadvmod gene,targeted
R718 T3346 T3348 amod targeted,mice
R719 T3179 T3180 det the,mutation
R720 T3347 T3346 punct -,targeted
R721 T3348 T3344 pobj mice,in
R722 T3180 T3178 pobj mutation,of
R723 T3181 T3180 compound lpr,mutation
R724 T3349 T3350 punct (,Bolland
R725 T3182 T3162 punct ", ",resolved
R726 T3350 T3335 meta Bolland,influences
R727 T3351 T3350 cc and,Bolland
R728 T3352 T3350 conj Ravetch,Bolland
R729 T3353 T3352 nummod 2000,Ravetch
R730 T3354 T3352 punct ;,Ravetch
R731 T3183 T3162 nsubjpass none,resolved
R732 T3355 T3352 conj Santiago,Ravetch
R733 T3356 T3355 punct -,Santiago
R734 T3357 T3355 nmod Raber,Santiago
R735 T3184 T3183 prep of,none
R736 T3358 T3355 nmod et,Santiago
R737 T3359 T3355 nmod al.,Santiago
R738 T3360 T3355 nummod 2001,Santiago
R739 T3185 T3186 det the,contributions
R740 T3361 T3355 punct ;,Santiago
R741 T3362 T3355 conj Mitchell,Santiago
R742 T3363 T3362 nmod et,Mitchell
R743 T3186 T3184 pobj contributions,of
R744 T3364 T3362 nmod al.,Mitchell
R745 T3365 T3362 nummod 2002,Mitchell
R746 T3366 T3362 punct ),Mitchell
R747 T3187 T3186 amod genetic,contributions
R748 T3367 T3335 punct .,influences
R749 T3369 T3370 det These,observations
R750 T3188 T3186 prep to,contributions
R751 T3370 T3371 nsubj observations,led
R752 T3189 T3188 pobj disease,to
R753 T3372 T3371 prep to,led
R754 T3373 T3374 det the,hypothesis
R755 T3374 T3372 pobj hypothesis,to
R756 T3190 T3186 prep in,contributions
R757 T3375 T3376 mark that,be
R758 T3376 T3374 acl be,hypothesis
R759 T3377 T3378 det the,phenotype
R760 T3191 T3192 det the,strains
R761 T3378 T3376 nsubj phenotype,be
R762 T3379 T3378 amod autoimmune,phenotype
R763 T3192 T3190 pobj strains,in
R764 T3380 T3378 acl described,phenotype
R765 T3381 T3380 prep in,described
R766 T3382 T3383 det some,mice
R767 T3193 T3192 nummod three,strains
R768 T3383 T3381 pobj mice,in
R769 T3384 T3385 npadvmod gene,targeted
R770 T3385 T3383 amod targeted,mice
R771 T3194 T3195 advmod well,documented
R772 T3386 T3385 punct -,targeted
R773 T3387 T3376 aux might,be
R774 T3388 T3376 prep due,be
R775 T3195 T3192 amod documented,strains
R776 T3389 T3388 advmod primarily,due
R777 T3390 T3388 pcomp to,due
R778 T3196 T3195 punct -,documented
R779 T3391 T3388 pobj combinations,due
R780 T3197 T3192 amod murine,strains
R781 T3392 T3391 prep of,combinations
R782 T3393 T3394 advmod as,yet
R783 T3394 T3396 advmod yet,uncharacterised
R784 T3395 T3394 punct -,yet
R785 T3396 T3398 amod uncharacterised,genes
R786 T3397 T3396 punct -,uncharacterised
R787 T3398 T3392 pobj genes,of
R788 T3399 T3398 compound background,genes
R789 T3198 T3192 compound SLE,strains
R790 T3400 T3398 punct ", ",genes
R791 T3401 T3398 acl originating,genes
R792 T3402 T3401 prep from,originating
R793 T3199 T3162 aux have,resolved
R794 T3403 T3404 nummod 129,strains
R795 T3200 T3162 advmod yet,resolved
R796 T3404 T3402 pobj strains,from
R797 T3405 T3403 cc and,129
R798 T3201 T3162 auxpass been,resolved
R799 T3406 T3403 conj C57BL,129
R800 T3407 T3406 punct /,C57BL
R801 T3408 T3406 nummod 6,C57BL
R802 T3202 T3162 advmod fully,resolved
R803 T3409 T3404 compound mice,strains
R804 T3410 T3391 punct ", ",combinations
R805 T3411 T3391 acl interacting,combinations
R806 T3203 T3162 prep at,resolved
R807 T3412 T3411 cc or,interacting
R808 T3413 T3411 conj not,interacting
R809 T3414 T3411 prep with,interacting
R810 T3204 T3205 det the,level
R811 T3415 T3416 det the,allele
R812 T3416 T3414 pobj allele,with
R813 T3205 T3203 pobj level,at
R814 T3417 T3416 amod mutated,allele
R815 T3418 T3371 punct .,led
R816 T3206 T3207 amod molecular,protein
R817 T3420 T3421 aux To,test
R818 T3421 T3422 advcl test,conducted
R819 T3207 T3205 compound protein,level
R820 T3423 T3421 dobj this,test
R821 T3208 T3207 cc or,protein
R822 T3424 T3422 punct ", ",conducted
R823 T3425 T3422 nsubj we,conducted
R824 T3426 T3427 det a,analysis
R825 T3209 T3162 punct .,resolved
R826 T3427 T3422 dobj analysis,conducted
R827 T3428 T3429 npadvmod genome,wide
R828 T3211 T3212 advmod Thus,used
R829 T3429 T3427 amod wide,analysis
R830 T3430 T3429 punct -,wide
R831 T3431 T3427 compound scan,analysis
R832 T3432 T3427 prep of,analysis
R833 T3433 T3434 nummod two,cohorts
R834 T3434 T3432 pobj cohorts,of
R835 T3435 T3434 amod large,cohorts
R836 T3213 T3212 punct ", ",used
R837 T3436 T3434 prep of,cohorts
R838 T3437 T3438 punct (,mice
R839 T3438 T3436 pobj mice,of
R840 T3439 T3438 nummod 129,mice
R841 T3214 T3215 amod targeted,disruption
R842 T3440 T3439 punct ×,129
R843 T3441 T3439 appos C57BL,129
R844 T3442 T3441 punct /,C57BL
R845 T3443 T3441 nummod 6,C57BL
R846 T3215 T3212 nsubjpass disruption,used
R847 T3444 T3438 punct ),mice
R848 T3445 T3438 compound F2,mice
R849 T3446 T3434 punct ", ",cohorts
R850 T3216 T3215 amod genetic,disruption
R851 T3447 T3448 dep one,carried
R852 T3448 T3434 relcl carried,cohorts
R853 T3217 T3215 prep of,disruption
R854 T3449 T3447 prep of,one
R855 T3450 T3449 pobj which,of
R856 T3218 T3219 compound candidate,genes
R857 T3451 T3452 det a,mutation
R858 T3219 T3217 pobj genes,of
R859 T3452 T3448 dobj mutation,carried
R860 T3453 T3448 prep in,carried
R861 T3220 T3219 acl encoding,genes
R862 T3454 T3455 det the,gene
R863 T3221 T3220 dobj proteins,encoding
R864 T3222 T3221 prep of,proteins
R865 T3223 T3224 det the,system
R866 T3455 T3453 pobj gene,in
R867 T3456 T3457 compound serum,component
R868 T3224 T3222 pobj system,of
R869 T3457 T3455 compound component,gene
R870 T3458 T3457 compound amyloid,component
R871 T3459 T3457 compound P,component
R872 T3225 T3224 amod immune,system
R873 T3460 T3461 punct (,Apcs
R874 T3461 T3455 parataxis Apcs,gene
R875 T3462 T3461 punct ),Apcs
R876 T3226 T3212 aux has,used
R877 T3463 T3422 punct .,conducted
R878 T3227 T3212 auxpass been,used
R879 T3465 T3466 det The,mice
R880 T3466 T3470 nsubjpass mice,chosen
R881 T3467 T3468 npadvmod Apcs,deficient
R882 T3228 T3212 advmod extensively,used
R883 T3468 T3466 amod deficient,mice
R884 T3469 T3468 punct -,deficient
R885 T3470 T3478 ccomp chosen,persists
R886 T3471 T3472 punct (,Apcs
R887 T3472 T3466 parataxis Apcs,mice
R888 T3229 T3230 aux to,examine
R889 T3473 T3472 punct −,Apcs
R890 T3474 T3472 punct /,Apcs
R891 T3475 T3472 punct −,Apcs
R892 T3230 T3212 advcl examine,used
R893 T3476 T3472 punct ),Apcs
R894 T3477 T3470 auxpass were,chosen
R895 T3231 T3232 poss their,role
R896 T3479 T3470 prep as,chosen
R897 T3480 T3481 det an,example
R898 T3481 T3479 pobj example,as
R899 T3232 T3230 dobj role,examine
R900 T3482 T3481 prep of,example
R901 T3483 T3484 det a,strain
R902 T3233 T3232 prep in,role
R903 T3484 T3482 pobj strain,of
R904 T3485 T3486 npadvmod gene,targeted
R905 T3486 T3484 amod targeted,strain
R906 T3234 T3235 amod immune,regulation
R907 T3487 T3486 punct -,targeted
R908 T3488 T3489 advmod previously,reported
R909 T3489 T3484 acl reported,strain
R910 T3235 T3233 pobj regulation,in
R911 T3490 T3491 aux to,develop
R912 T3491 T3489 xcomp develop,reported
R913 T3236 T3212 punct .,used
R914 T3238 T3239 advmod However,been
R915 T3492 T3493 det a,disease
R916 T3493 T3491 dobj disease,develop
R917 T3494 T3495 npadvmod lupus,like
R918 T3240 T3239 punct ", ",been
R919 T3495 T3493 amod like,disease
R920 T3496 T3495 punct -,like
R921 T3497 T3491 prep on,develop
R922 T3498 T3499 det the,C57BL
R923 T3241 T3242 det the,result
R924 T3499 T3497 pobj C57BL,on
R925 T3500 T3499 nmod hybrid,C57BL
R926 T3242 T3239 nsubj result,been
R927 T3501 T3499 amod genetic,C57BL
R928 T3502 T3499 nmod background,C57BL
R929 T3560 T3551 punct ", ",Chromosome
R930 T3503 T3499 punct (,C57BL
R931 T3504 T3499 nummod 129,C57BL
R932 T3505 T3499 punct ×,C57BL
R933 T3506 T3499 punct /,C57BL
R934 T3507 T3499 nummod 6,C57BL
R935 T3508 T3499 punct ),C57BL
R936 T3561 T3551 prep within,Chromosome
R937 T3509 T3478 punct ;,persists
R938 T3510 T3478 nsubj autoimmunity,persists
R939 T3511 T3510 prep in,autoimmunity
R940 T3512 T3513 nmod Apcs,mice
R941 T3513 T3511 pobj mice,in
R942 T3562 T3563 det a,region
R943 T3514 T3512 punct −,Apcs
R944 T3515 T3512 punct /,Apcs
R945 T3516 T3512 punct −,Apcs
R946 T3563 T3561 pobj region,within
R947 T3517 T3518 advmod even,after
R948 T3518 T3478 prep after,persists
R949 T3519 T3518 pcomp backcrossing,after
R950 T3520 T3521 det the,gene
R951 T3564 T3565 advmod where,mapped
R952 T3521 T3519 dobj gene,backcrossing
R953 T3522 T3521 amod mutated,gene
R954 T3565 T3563 relcl mapped,region
R955 T3523 T3519 prep onto,backcrossing
R956 T3524 T3523 pobj C57BL,onto
R957 T3525 T3524 punct /,C57BL
R958 T3526 T3524 nummod 6,C57BL
R959 T3527 T3528 punct (,Bickerstaff
R960 T3566 T3567 amod several,loci
R961 T3528 T3519 meta Bickerstaff,backcrossing
R962 T3529 T3528 nmod et,Bickerstaff
R963 T3530 T3528 nmod al.,Bickerstaff
R964 T3567 T3565 nsubjpass loci,mapped
R965 T3531 T3528 nummod 1999,Bickerstaff
R966 T3532 T3528 punct ),Bickerstaff
R967 T3533 T3478 punct .,persists
R968 T3568 T3569 compound lupus,susceptibility
R969 T3535 T3536 nsubj We,chose
R970 T3569 T3567 compound susceptibility,loci
R971 T3537 T3538 det this,gene
R972 T3538 T3536 dobj gene,chose
R973 T3570 T3569 punct -,susceptibility
R974 T3539 T3538 amod targeted,gene
R975 T3540 T3536 prep in,chose
R976 T3541 T3540 amod particular,in
R977 T3571 T3567 punct ", ",loci
R978 T3542 T3543 aux to,study
R979 T3543 T3536 advcl study,chose
R980 T3544 T3545 mark since,located
R981 T3572 T3567 acl designated,loci
R982 T3545 T3536 advcl located,chose
R983 T3546 T3547 det the,gene
R984 T3573 T3572 oprd Sle1,designated
R985 T3547 T3545 nsubjpass gene,located
R986 T3548 T3547 compound Apcs,gene
R987 T3549 T3545 auxpass is,located
R988 T3574 T3575 punct (,Morel
R989 T3550 T3545 prep on,located
R990 T3551 T3550 pobj Chromosome,on
R991 T3552 T3551 nummod 1,Chromosome
R992 T3553 T3551 punct ", ",Chromosome
R993 T3554 T3555 advmod approximately,94
R994 T3575 T3573 meta Morel,Sle1
R995 T3555 T3556 nummod 94,cM
R996 T3556 T3557 npadvmod cM,from
R997 T3557 T3551 prep from,Chromosome
R998 T3576 T3575 nmod et,Morel
R999 T3558 T3559 det the,centromere