PMC:48141 JSON TXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id	Subject	Object	Predicate	Lexical cue
T28	0-11	JJ	denotes	Intraocular
T30	0-78	sentence	denotes	Intraocular pressure in genetically distinct mice: an update and strain survey
T29	12-20	NN	denotes	pressure
T32	21-23	IN	denotes	in
T33	24-35	RB	denotes	genetically
T34	36-44	JJ	denotes	distinct
T35	45-49	NNS	denotes	mice
T36	49-51	:	denotes	:
T37	51-53	DT	denotes	an
T31	54-60	NN	denotes	update
T38	61-64	CC	denotes	and
T39	65-71	NN	denotes	strain
T40	72-78	NN	denotes	survey
T41	78-79	sentence	denotes
T42	89-99	sentence	denotes	Background
T43	89-99	NN	denotes	Background
T44	99-201	sentence	denotes	Little is known about genetic factors affecting intraocular pressure (IOP) in mice and other mammals.
T45	100-106	JJ	denotes	Little
T47	107-109	VBZ	denotes	is
T46	110-115	VBN	denotes	known
T48	116-121	IN	denotes	about
T49	122-129	JJ	denotes	genetic
T50	130-137	NNS	denotes	factors
T51	138-147	VBG	denotes	affecting
T52	148-159	JJ	denotes	intraocular
T53	160-168	NN	denotes	pressure
T54	169-170	-LRB-	denotes	(
T55	170-173	NN	denotes	IOP
T56	173-174	-RRB-	denotes	)
T57	175-177	IN	denotes	in
T58	178-182	NNS	denotes	mice
T59	183-186	CC	denotes	and
T60	187-192	JJ	denotes	other
T61	193-200	NNS	denotes	mammals
T62	200-201	.	denotes	.
T63	201-465	sentence	denotes	The purpose of this study was to determine the IOPs of genetically distinct mouse strains, assess the effects of factors such as age, sex and time of day on IOP in specific strain backgrounds, and to assess the effects of specific candidate gene mutations on IOP.
T64	202-205	DT	denotes	The
T65	206-213	NN	denotes	purpose
T67	214-216	IN	denotes	of
T68	217-221	DT	denotes	this
T69	222-227	NN	denotes	study
T66	228-231	VBD	denotes	was
T70	232-234	TO	denotes	to
T71	235-244	VB	denotes	determine
T72	245-248	DT	denotes	the
T73	249-253	NNS	denotes	IOPs
T74	254-256	IN	denotes	of
T75	257-268	RB	denotes	genetically
T76	269-277	JJ	denotes	distinct
T78	278-283	NN	denotes	mouse
T77	284-291	NNS	denotes	strains
T79	291-293	,	denotes	,
T80	293-299	VB	denotes	assess
T81	300-303	DT	denotes	the
T82	304-311	NNS	denotes	effects
T83	312-314	IN	denotes	of
T84	315-322	NNS	denotes	factors
T85	323-327	JJ	denotes	such
T86	328-330	IN	denotes	as
T87	331-334	NN	denotes	age
T88	334-336	,	denotes	,
T89	336-339	NN	denotes	sex
T90	340-343	CC	denotes	and
T91	344-348	NN	denotes	time
T92	349-351	IN	denotes	of
T93	352-355	NN	denotes	day
T94	356-358	IN	denotes	on
T95	359-362	NN	denotes	IOP
T96	363-365	IN	denotes	in
T97	366-374	JJ	denotes	specific
T99	375-381	NN	denotes	strain
T98	382-393	NNS	denotes	backgrounds
T100	393-395	,	denotes	,
T101	395-398	CC	denotes	and
T102	399-401	TO	denotes	to
T103	402-408	VB	denotes	assess
T104	409-412	DT	denotes	the
T105	413-420	NNS	denotes	effects
T106	421-423	IN	denotes	of
T107	424-432	JJ	denotes	specific
T109	433-442	NN	denotes	candidate
T110	443-447	NN	denotes	gene
T108	448-457	NNS	denotes	mutations
T111	458-460	IN	denotes	on
T112	461-464	NN	denotes	IOP
T113	464-465	.	denotes	.
T114	465-474	sentence	denotes	Results
T115	467-474	NNS	denotes	Results
T116	474-567	sentence	denotes	Based on over 30 studied mouse strains, average IOP ranges from approximately 10 to 20 mmHg.
T117	475-480	VBN	denotes	Based
T119	481-483	IN	denotes	on
T120	484-488	IN	denotes	over
T121	489-491	CD	denotes	30
T123	492-499	VBN	denotes	studied
T124	500-505	NN	denotes	mouse
T122	506-513	NNS	denotes	strains
T125	513-515	,	denotes	,
T126	515-522	JJ	denotes	average
T127	523-526	NN	denotes	IOP
T118	527-533	VBZ	denotes	ranges
T128	534-538	IN	denotes	from
T129	539-552	RB	denotes	approximately
T130	553-555	CD	denotes	10
T131	556-558	IN	denotes	to
T132	559-561	CD	denotes	20
T133	562-566	NN	denotes	mmHg
T134	566-567	.	denotes	.
T135	567-658	sentence	denotes	Gender does not typically affect IOP and aging results in an IOP decrease in some strains.
T136	568-574	NN	denotes	Gender
T138	575-579	VBZ	denotes	does
T139	580-583	RB	denotes	not
T140	584-593	RB	denotes	typically
T137	594-600	VB	denotes	affect
T141	601-604	NN	denotes	IOP
T142	605-608	CC	denotes	and
T143	609-614	NN	denotes	aging
T144	615-622	VBZ	denotes	results
T145	623-625	IN	denotes	in
T146	626-628	DT	denotes	an
T148	629-632	NN	denotes	IOP
T147	633-641	NN	denotes	decrease
T149	642-644	IN	denotes	in
T150	645-649	DT	denotes	some
T151	650-657	NNS	denotes	strains
T152	657-658	.	denotes	.
T153	658-765	sentence	denotes	Most tested strains exhibit a diurnal rhythm with IOP being the highest during the dark period of the day.
T154	659-663	JJS	denotes	Most
T156	664-670	JJ	denotes	tested
T155	671-678	NNS	denotes	strains
T157	679-686	VBP	denotes	exhibit
T158	687-688	DT	denotes	a
T160	689-696	JJ	denotes	diurnal
T159	697-703	NN	denotes	rhythm
T161	704-708	IN	denotes	with
T162	709-712	NN	denotes	IOP
T163	713-718	VBG	denotes	being
T164	719-722	DT	denotes	the
T165	723-730	JJS	denotes	highest
T166	731-737	IN	denotes	during
T167	738-741	DT	denotes	the
T169	742-746	JJ	denotes	dark
T168	747-753	NN	denotes	period
T170	754-756	IN	denotes	of
T171	757-760	DT	denotes	the
T172	761-764	NN	denotes	day
T173	764-765	.	denotes	.
T174	765-987	sentence	denotes	Homozygosity for a null allele of the carbonic anhydrase II gene (Car2n) does not alter IOP while homozygosity for a mutation in the leptin receptor gene (Leprdb) that causes obesity and diabetes results in increased IOP.
T175	766-778	NN	denotes	Homozygosity
T177	779-782	IN	denotes	for
T178	783-784	DT	denotes	a
T180	785-789	JJ	denotes	null
T179	790-796	NN	denotes	allele
T181	797-799	IN	denotes	of
T182	800-803	DT	denotes	the
T184	804-812	JJ	denotes	carbonic
T185	813-822	NN	denotes	anhydrase
T186	823-825	CD	denotes	II
T183	826-830	NN	denotes	gene
T187	831-832	-LRB-	denotes	(
T188	832-837	NN	denotes	Car2n
T189	837-838	-RRB-	denotes	)
T190	839-843	VBZ	denotes	does
T191	844-847	RB	denotes	not
T176	848-853	VB	denotes	alter
T192	854-857	NN	denotes	IOP
T193	858-863	IN	denotes	while
T195	864-876	NN	denotes	homozygosity
T196	877-880	IN	denotes	for
T197	881-882	DT	denotes	a
T198	883-891	NN	denotes	mutation
T199	892-894	IN	denotes	in
T200	895-898	DT	denotes	the
T202	899-905	NN	denotes	leptin
T203	906-914	NN	denotes	receptor
T201	915-919	NN	denotes	gene
T204	920-921	-LRB-	denotes	(
T205	921-927	NN	denotes	Leprdb
T206	927-928	-RRB-	denotes	)
T207	929-933	WDT	denotes	that
T208	934-940	VBZ	denotes	causes
T209	941-948	NN	denotes	obesity
T210	949-952	CC	denotes	and
T211	953-961	NN	denotes	diabetes
T194	962-969	VBZ	denotes	results
T212	970-972	IN	denotes	in
T213	973-982	VBN	denotes	increased
T214	983-986	NN	denotes	IOP
T215	986-987	.	denotes	.
T216	987-1107	sentence	denotes	Albino C57BL/6J mice homozygous for a tyrosinase mutation (Tyrc-2J) have higher IOPs than their pigmented counterparts.
T217	988-994	NN	denotes	Albino
T219	995-1000	NN	denotes	C57BL
T221	1000-1001	HYPH	denotes	/
T220	1001-1003	NN	denotes	6J
T218	1004-1008	NNS	denotes	mice
T223	1009-1019	JJ	denotes	homozygous
T224	1020-1023	IN	denotes	for
T225	1024-1025	DT	denotes	a
T227	1026-1036	NN	denotes	tyrosinase
T226	1037-1045	NN	denotes	mutation
T228	1046-1047	-LRB-	denotes	(
T229	1047-1051	NN	denotes	Tyrc
T231	1051-1052	HYPH	denotes	-
T230	1052-1054	NN	denotes	2J
T232	1054-1055	-RRB-	denotes	)
T222	1056-1060	VBP	denotes	have
T233	1061-1067	JJR	denotes	higher
T234	1068-1072	NNS	denotes	IOPs
T235	1073-1077	IN	denotes	than
T236	1078-1083	PRP$	denotes	their
T238	1084-1093	JJ	denotes	pigmented
T237	1094-1106	NNS	denotes	counterparts
T239	1106-1107	.	denotes	.
T240	1107-1120	sentence	denotes	Conclusions
T241	1109-1120	NNS	denotes	Conclusions
T242	1120-1214	sentence	denotes	Genetically distinct mouse strains housed in the same environment have a broad range of IOPs.
T243	1121-1132	RB	denotes	Genetically
T244	1133-1141	JJ	denotes	distinct
T246	1142-1147	NN	denotes	mouse
T245	1148-1155	NNS	denotes	strains
T248	1156-1162	VBN	denotes	housed
T249	1163-1165	IN	denotes	in
T250	1166-1169	DT	denotes	the
T252	1170-1174	JJ	denotes	same
T251	1175-1186	NN	denotes	environment
T247	1187-1191	VBP	denotes	have
T253	1192-1193	DT	denotes	a
T255	1194-1199	JJ	denotes	broad
T254	1200-1205	NN	denotes	range
T256	1206-1208	IN	denotes	of
T257	1209-1213	NNS	denotes	IOPs
T258	1213-1214	.	denotes	.
T259	1214-1354	sentence	denotes	These IOP differences are likely due to interstrain genetic differences that create a powerful resource for studying the regulation of IOP.
T260	1215-1220	DT	denotes	These
T262	1221-1224	NNP	denotes	IOP
T261	1225-1236	NNS	denotes	differences
T263	1237-1240	VBP	denotes	are
T264	1241-1247	RB	denotes	likely
T265	1248-1251	IN	denotes	due
T266	1252-1254	IN	denotes	to
T267	1255-1266	JJ	denotes	interstrain
T269	1267-1274	JJ	denotes	genetic
T268	1275-1286	NNS	denotes	differences
T270	1287-1291	WDT	denotes	that
T271	1292-1298	VBP	denotes	create
T272	1299-1300	DT	denotes	a
T274	1301-1309	JJ	denotes	powerful
T273	1310-1318	NN	denotes	resource
T275	1319-1322	IN	denotes	for
T276	1323-1331	VBG	denotes	studying
T277	1332-1335	DT	denotes	the
T278	1336-1346	NN	denotes	regulation
T279	1347-1349	IN	denotes	of
T280	1350-1353	NN	denotes	IOP
T281	1353-1354	.	denotes	.
T282	1354-1465	sentence	denotes	Age, time of day, obesity and diabetes have effects on mouse IOP similar to those in humans and other species.
T283	1355-1358	NN	denotes	Age
T285	1358-1360	,	denotes	,
T286	1360-1364	NN	denotes	time
T287	1365-1367	IN	denotes	of
T288	1368-1371	NN	denotes	day
T289	1371-1373	,	denotes	,
T290	1373-1380	NN	denotes	obesity
T291	1381-1384	CC	denotes	and
T292	1385-1393	NN	denotes	diabetes
T284	1394-1398	VBP	denotes	have
T293	1399-1406	NNS	denotes	effects
T294	1407-1409	IN	denotes	on
T295	1410-1415	NN	denotes	mouse
T296	1416-1419	NN	denotes	IOP
T297	1420-1427	JJ	denotes	similar
T298	1428-1430	IN	denotes	to
T299	1431-1436	DT	denotes	those
T300	1437-1439	IN	denotes	in
T301	1440-1446	NNS	denotes	humans
T302	1447-1450	CC	denotes	and
T303	1451-1456	JJ	denotes	other
T304	1457-1464	NNS	denotes	species
T305	1464-1465	.	denotes	.
T306	1465-1554	sentence	denotes	Mutations in two of the assessed candidate genes (Lepr and Tyr) result in increased IOP.
T307	1466-1475	NNS	denotes	Mutations
T309	1476-1478	IN	denotes	in
T310	1479-1482	CD	denotes	two
T311	1483-1485	IN	denotes	of
T312	1486-1489	DT	denotes	the
T314	1490-1498	VBN	denotes	assessed
T315	1499-1508	NN	denotes	candidate
T313	1509-1514	NNS	denotes	genes
T316	1515-1516	-LRB-	denotes	(
T317	1516-1520	NN	denotes	Lepr
T318	1521-1524	CC	denotes	and
T319	1525-1528	NN	denotes	Tyr
T320	1528-1529	-RRB-	denotes	)
T308	1530-1536	VBP	denotes	result
T321	1537-1539	IN	denotes	in
T322	1540-1549	JJ	denotes	increased
T323	1550-1553	NN	denotes	IOP
T324	1553-1554	.	denotes	.
T325	1554-1735	sentence	denotes	These studies demonstrate that mice are a practical and powerful experimental system to study the genetics of IOP regulation and disease processes that raise IOP to harmful levels.
T326	1555-1560	DT	denotes	These
T327	1561-1568	NNS	denotes	studies
T328	1569-1580	VBP	denotes	demonstrate
T329	1581-1585	IN	denotes	that
T331	1586-1590	NNS	denotes	mice
T330	1591-1594	VBP	denotes	are
T332	1595-1596	DT	denotes	a
T334	1597-1606	JJ	denotes	practical
T335	1607-1610	CC	denotes	and
T336	1611-1619	JJ	denotes	powerful
T337	1620-1632	JJ	denotes	experimental
T333	1633-1639	NN	denotes	system
T338	1640-1642	TO	denotes	to
T339	1643-1648	VB	denotes	study
T340	1649-1652	DT	denotes	the
T341	1653-1661	NN	denotes	genetics
T342	1662-1664	IN	denotes	of
T343	1665-1668	NN	denotes	IOP
T344	1669-1679	NN	denotes	regulation
T345	1680-1683	CC	denotes	and
T346	1684-1691	NN	denotes	disease
T347	1692-1701	NNS	denotes	processes
T348	1702-1706	WDT	denotes	that
T349	1707-1712	VBP	denotes	raise
T350	1713-1716	NN	denotes	IOP
T351	1717-1719	IN	denotes	to
T352	1720-1727	JJ	denotes	harmful
T353	1728-1734	NNS	denotes	levels
T354	1734-1735	.	denotes	.
T445	1748-1756	NN	denotes	Glaucoma
T446	1757-1759	VBZ	denotes	is
T447	1760-1761	DT	denotes	a
T449	1762-1769	VBG	denotes	leading
T448	1770-1775	NN	denotes	cause
T450	1776-1778	IN	denotes	of
T451	1779-1788	NN	denotes	blindness
T452	1789-1792	CC	denotes	but
T453	1793-1796	PRP$	denotes	its
T455	1797-1806	JJ	denotes	molecular
T454	1807-1815	NN	denotes	etiology
T456	1816-1818	VBZ	denotes	is
T457	1819-1825	RB	denotes	poorly
T458	1826-1836	JJ	denotes	understood
T459	1836-1837	.	denotes	.
T460	1837-1979	sentence	denotes	Glaucoma involves retinal ganglion cell death and optic nerve damage that is often associated with elevated intraocular pressure (IOP) [1-5].
T461	1838-1846	NN	denotes	Glaucoma
T462	1847-1855	VBZ	denotes	involves
T463	1856-1863	JJ	denotes	retinal
T464	1864-1872	NN	denotes	ganglion
T466	1873-1877	NN	denotes	cell
T465	1878-1883	NN	denotes	death
T467	1884-1887	CC	denotes	and
T468	1888-1893	JJ	denotes	optic
T470	1894-1899	NN	denotes	nerve
T469	1900-1906	NN	denotes	damage
T471	1907-1911	WDT	denotes	that
T473	1912-1914	VBZ	denotes	is
T474	1915-1920	RB	denotes	often
T472	1921-1931	VBN	denotes	associated
T475	1932-1936	IN	denotes	with
T476	1937-1945	JJ	denotes	elevated
T478	1946-1957	JJ	denotes	intraocular
T477	1958-1966	NN	denotes	pressure
T479	1967-1968	-LRB-	denotes	(
T480	1968-1971	NN	denotes	IOP
T481	1971-1972	-RRB-	denotes	)
T482	1973-1974	-LRB-	denotes	[
T483	1974-1975	CD	denotes	1
T484	1975-1976	SYM	denotes	-
T485	1976-1977	CD	denotes	5
T486	1977-1978	-RRB-	denotes	]
T487	1978-1979	.	denotes	.
T488	1979-2191	sentence	denotes	It is becoming increasingly clear that many forms of glaucoma have a genetic component [6,7], and much current research is focused on identifying chromosomal regions and genes that contribute to glaucoma [8-10].
T489	1980-1982	PRP	denotes	It
T491	1983-1985	VBZ	denotes	is
T490	1986-1994	VBG	denotes	becoming
T492	1995-2007	RB	denotes	increasingly
T493	2008-2013	JJ	denotes	clear
T494	2014-2018	IN	denotes	that
T496	2019-2023	JJ	denotes	many
T497	2024-2029	NNS	denotes	forms
T498	2030-2032	IN	denotes	of
T499	2033-2041	NN	denotes	glaucoma
T495	2042-2046	VBP	denotes	have
T500	2047-2048	DT	denotes	a
T502	2049-2056	JJ	denotes	genetic
T501	2057-2066	NN	denotes	component
T503	2067-2068	-LRB-	denotes	[
T505	2068-2069	CD	denotes	6
T506	2069-2070	,	denotes	,
T504	2070-2071	CD	denotes	7
T507	2071-2072	-RRB-	denotes	]
T508	2072-2074	,	denotes	,
T509	2074-2077	CC	denotes	and
T510	2078-2082	JJ	denotes	much
T512	2083-2090	JJ	denotes	current
T511	2091-2099	NN	denotes	research
T514	2100-2102	VBZ	denotes	is
T513	2103-2110	VBN	denotes	focused
T515	2111-2113	IN	denotes	on
T516	2114-2125	VBG	denotes	identifying
T517	2126-2137	JJ	denotes	chromosomal
T518	2138-2145	NNS	denotes	regions
T519	2146-2149	CC	denotes	and
T520	2150-2155	NNS	denotes	genes
T521	2156-2160	WDT	denotes	that
T522	2161-2171	VBP	denotes	contribute
T523	2172-2174	IN	denotes	to
T524	2175-2183	NN	denotes	glaucoma
T525	2184-2185	-LRB-	denotes	[
T526	2185-2186	CD	denotes	8
T527	2186-2187	SYM	denotes	-
T528	2187-2189	CD	denotes	10
T529	2189-2190	-RRB-	denotes	]
T530	2190-2191	.	denotes	.
T531	2191-2298	sentence	denotes	Identifying such loci allows screening for individuals with an increased risk of developing glaucoma [11].
T532	2192-2203	VBG	denotes	Identifying
T534	2204-2208	JJ	denotes	such
T535	2209-2213	NNS	denotes	loci
T533	2214-2220	VBZ	denotes	allows
T536	2221-2230	VBG	denotes	screening
T537	2231-2234	IN	denotes	for
T538	2235-2246	NNS	denotes	individuals
T539	2247-2251	IN	denotes	with
T540	2252-2254	DT	denotes	an
T542	2255-2264	VBN	denotes	increased
T541	2265-2269	NN	denotes	risk
T543	2270-2272	IN	denotes	of
T544	2273-2283	VBG	denotes	developing
T545	2284-2292	NN	denotes	glaucoma
T546	2293-2294	-LRB-	denotes	[
T547	2294-2296	CD	denotes	11
T548	2296-2297	-RRB-	denotes	]
T549	2297-2298	.	denotes	.
T550	2298-2509	sentence	denotes	Identifying genes contributing to elevated IOP and glaucoma is only the first step, however, and animal models will provide systems for subsequent hypothesis testing and experimental dissection of pathogenesis.
T551	2299-2310	VBG	denotes	Identifying
T553	2311-2316	NNS	denotes	genes
T554	2317-2329	VBG	denotes	contributing
T555	2330-2332	IN	denotes	to
T556	2333-2341	VBN	denotes	elevated
T557	2342-2345	NN	denotes	IOP
T558	2346-2349	CC	denotes	and
T559	2350-2358	NN	denotes	glaucoma
T552	2359-2361	VBZ	denotes	is
T560	2362-2366	RB	denotes	only
T562	2367-2370	DT	denotes	the
T563	2371-2376	JJ	denotes	first
T561	2377-2381	NN	denotes	step
T564	2381-2383	,	denotes	,
T565	2383-2390	RB	denotes	however
T566	2390-2392	,	denotes	,
T567	2392-2395	CC	denotes	and
T568	2396-2402	NN	denotes	animal
T569	2403-2409	NNS	denotes	models
T571	2410-2414	MD	denotes	will
T570	2415-2422	VB	denotes	provide
T572	2423-2430	NNS	denotes	systems
T573	2431-2434	IN	denotes	for
T574	2435-2445	JJ	denotes	subsequent
T576	2446-2456	NN	denotes	hypothesis
T575	2457-2464	NN	denotes	testing
T577	2465-2468	CC	denotes	and
T578	2469-2481	JJ	denotes	experimental
T579	2482-2492	NN	denotes	dissection
T580	2493-2495	IN	denotes	of
T581	2496-2508	NN	denotes	pathogenesis
T582	2508-2509	.	denotes	.
T583	2509-2767	sentence	denotes	Due to conservation in mammalian physiology and the powerful tools of mouse genetics, mice are a very important experimental system for probing the functions (both in health and disease) of many genes recently identified by sequencing the human genome [12].
T584	2510-2513	IN	denotes	Due
T586	2514-2516	IN	denotes	to
T587	2517-2529	NN	denotes	conservation
T588	2530-2532	IN	denotes	in
T589	2533-2542	JJ	denotes	mammalian
T590	2543-2553	NN	denotes	physiology
T591	2554-2557	CC	denotes	and
T592	2558-2561	DT	denotes	the
T594	2562-2570	JJ	denotes	powerful
T593	2571-2576	NNS	denotes	tools
T595	2577-2579	IN	denotes	of
T596	2580-2585	NN	denotes	mouse
T597	2586-2594	NN	denotes	genetics
T598	2594-2596	,	denotes	,
T599	2596-2600	NNS	denotes	mice
T585	2601-2604	VBP	denotes	are
T600	2605-2606	DT	denotes	a
T602	2607-2611	RB	denotes	very
T603	2612-2621	JJ	denotes	important
T604	2622-2634	JJ	denotes	experimental
T601	2635-2641	NN	denotes	system
T605	2642-2645	IN	denotes	for
T606	2646-2653	VBG	denotes	probing
T607	2654-2657	DT	denotes	the
T608	2658-2667	NNS	denotes	functions
T609	2668-2669	-LRB-	denotes	(
T610	2669-2673	CC	denotes	both
T611	2674-2676	IN	denotes	in
T612	2677-2683	NN	denotes	health
T613	2684-2687	CC	denotes	and
T614	2688-2695	NN	denotes	disease
T615	2695-2696	-RRB-	denotes	)
T616	2697-2699	IN	denotes	of
T617	2700-2704	JJ	denotes	many
T618	2705-2710	NNS	denotes	genes
T619	2711-2719	RB	denotes	recently
T620	2720-2730	VBN	denotes	identified
T621	2731-2733	IN	denotes	by
T622	2734-2744	VBG	denotes	sequencing
T623	2745-2748	DT	denotes	the
T625	2749-2754	JJ	denotes	human
T624	2755-2761	NN	denotes	genome
T626	2762-2763	-LRB-	denotes	[
T627	2763-2765	CD	denotes	12
T628	2765-2766	-RRB-	denotes	]
T629	2766-2767	.	denotes	.
T630	2767-2852	sentence	denotes	We have focused on developing the mouse system for IOP and glaucoma studies [13-19].
T631	2768-2770	PRP	denotes	We
T633	2771-2775	VBP	denotes	have
T632	2776-2783	VBN	denotes	focused
T634	2784-2786	IN	denotes	on
T635	2787-2797	VBG	denotes	developing
T636	2798-2801	DT	denotes	the
T638	2802-2807	NN	denotes	mouse
T637	2808-2814	NN	denotes	system
T639	2815-2818	IN	denotes	for
T640	2819-2822	NN	denotes	IOP
T641	2823-2826	CC	denotes	and
T642	2827-2835	NN	denotes	glaucoma
T643	2836-2843	NNS	denotes	studies
T644	2844-2845	-LRB-	denotes	[
T645	2845-2847	CD	denotes	13
T646	2847-2848	SYM	denotes	-
T647	2848-2850	CD	denotes	19
T648	2850-2851	-RRB-	denotes	]
T649	2851-2852	.	denotes	.
T650	2852-3030	sentence	denotes	Mice are expected to be extremely helpful in characterizing genes and mechanisms that affect IOP or the susceptibility of the optic nerve and retina to glaucomatous damage [20].
T651	2853-2857	NNS	denotes	Mice
T653	2858-2861	VBP	denotes	are
T652	2862-2870	VBN	denotes	expected
T654	2871-2873	TO	denotes	to
T655	2874-2876	VB	denotes	be
T656	2877-2886	RB	denotes	extremely
T657	2887-2894	JJ	denotes	helpful
T658	2895-2897	IN	denotes	in
T659	2898-2912	VBG	denotes	characterizing
T660	2913-2918	NNS	denotes	genes
T661	2919-2922	CC	denotes	and
T662	2923-2933	NNS	denotes	mechanisms
T663	2934-2938	WDT	denotes	that
T664	2939-2945	VBP	denotes	affect
T665	2946-2949	NN	denotes	IOP
T666	2950-2952	CC	denotes	or
T667	2953-2956	DT	denotes	the
T668	2957-2971	NN	denotes	susceptibility
T669	2972-2974	IN	denotes	of
T670	2975-2978	DT	denotes	the
T672	2979-2984	JJ	denotes	optic
T671	2985-2990	NN	denotes	nerve
T673	2991-2994	CC	denotes	and
T674	2995-3001	NN	denotes	retina
T675	3002-3004	IN	denotes	to
T676	3005-3017	JJ	denotes	glaucomatous
T677	3018-3024	NN	denotes	damage
T678	3025-3026	-LRB-	denotes	[
T679	3026-3028	CD	denotes	20
T680	3028-3029	-RRB-	denotes	]
T681	3029-3030	.	denotes	.
T682	3030-3158	sentence	denotes	Very little is known about the magnitude of IOP of various mouse strains or IOP fluctuation in mice with time or other factors.
T683	3031-3035	RB	denotes	Very
T684	3036-3042	JJ	denotes	little
T686	3043-3045	VBZ	denotes	is
T685	3046-3051	VBN	denotes	known
T687	3052-3057	IN	denotes	about
T688	3058-3061	DT	denotes	the
T689	3062-3071	NN	denotes	magnitude
T690	3072-3074	IN	denotes	of
T691	3075-3078	NN	denotes	IOP
T692	3079-3081	IN	denotes	of
T693	3082-3089	JJ	denotes	various
T695	3090-3095	NN	denotes	mouse
T694	3096-3103	NNS	denotes	strains
T696	3104-3106	CC	denotes	or
T697	3107-3110	NN	denotes	IOP
T698	3111-3122	NN	denotes	fluctuation
T699	3123-3125	IN	denotes	in
T700	3126-3130	NNS	denotes	mice
T701	3131-3135	IN	denotes	with
T702	3136-3140	NN	denotes	time
T703	3141-3143	CC	denotes	or
T704	3144-3149	JJ	denotes	other
T705	3150-3157	NNS	denotes	factors
T706	3157-3158	.	denotes	.
T707	3158-3281	sentence	denotes	Previously, we developed a method to measure IOP in mice and reported initial findings on the magnitude of mouse IOP [13].
T708	3159-3169	RB	denotes	Previously
T710	3169-3171	,	denotes	,
T711	3171-3173	PRP	denotes	we
T709	3174-3183	VBD	denotes	developed
T712	3184-3185	DT	denotes	a
T713	3186-3192	NN	denotes	method
T714	3193-3195	TO	denotes	to
T715	3196-3203	VB	denotes	measure
T716	3204-3207	NN	denotes	IOP
T717	3208-3210	IN	denotes	in
T718	3211-3215	NNS	denotes	mice
T719	3216-3219	CC	denotes	and
T720	3220-3228	VBD	denotes	reported
T721	3229-3236	JJ	denotes	initial
T722	3237-3245	NNS	denotes	findings
T723	3246-3248	IN	denotes	on
T724	3249-3252	DT	denotes	the
T725	3253-3262	NN	denotes	magnitude
T726	3263-3265	IN	denotes	of
T727	3266-3271	NN	denotes	mouse
T728	3272-3275	NN	denotes	IOP
T729	3276-3277	-LRB-	denotes	[
T730	3277-3279	CD	denotes	13
T731	3279-3280	-RRB-	denotes	]
T732	3280-3281	.	denotes	.
T733	3281-3382	sentence	denotes	The procedure involves direct measurement of pressure following cannulation of the anterior chamber.
T734	3282-3285	DT	denotes	The
T735	3286-3295	NN	denotes	procedure
T736	3296-3304	VBZ	denotes	involves
T737	3305-3311	JJ	denotes	direct
T738	3312-3323	NN	denotes	measurement
T739	3324-3326	IN	denotes	of
T740	3327-3335	NN	denotes	pressure
T741	3336-3345	VBG	denotes	following
T742	3346-3357	NN	denotes	cannulation
T743	3358-3360	IN	denotes	of
T744	3361-3364	DT	denotes	the
T746	3365-3373	JJ	denotes	anterior
T745	3374-3381	NN	denotes	chamber
T747	3381-3382	.	denotes	.
T748	3382-3634	sentence	denotes	The initial experiments demonstrated that in our hands careful ocular cannulation has a very minor effect on IOP (average of -0.3 mmHg, mode -0.5 mmHg) and demonstrated significant differences in intraocular pressure levels between four mouse strains.
T749	3383-3386	DT	denotes	The
T751	3387-3394	JJ	denotes	initial
T750	3395-3406	NNS	denotes	experiments
T752	3407-3419	VBD	denotes	demonstrated
T753	3420-3424	IN	denotes	that
T755	3425-3427	IN	denotes	in
T756	3428-3431	PRP$	denotes	our
T757	3432-3437	NNS	denotes	hands
T758	3438-3445	JJ	denotes	careful
T760	3446-3452	JJ	denotes	ocular
T759	3453-3464	NN	denotes	cannulation
T754	3465-3468	VBZ	denotes	has
T761	3469-3470	DT	denotes	a
T763	3471-3475	RB	denotes	very
T764	3476-3481	JJ	denotes	minor
T762	3482-3488	NN	denotes	effect
T765	3489-3491	IN	denotes	on
T766	3492-3495	NN	denotes	IOP
T767	3496-3497	-LRB-	denotes	(
T769	3497-3504	NN	denotes	average
T770	3505-3507	IN	denotes	of
T771	3508-3509	SYM	denotes	-
T772	3509-3512	CD	denotes	0.3
T773	3513-3517	NN	denotes	mmHg
T774	3517-3519	,	denotes	,
T768	3519-3523	NN	denotes	mode
T775	3524-3525	SYM	denotes	-
T776	3525-3528	CD	denotes	0.5
T777	3529-3533	NN	denotes	mmHg
T778	3533-3534	-RRB-	denotes	)
T779	3535-3538	CC	denotes	and
T780	3539-3551	VBD	denotes	demonstrated
T781	3552-3563	JJ	denotes	significant
T782	3564-3575	NNS	denotes	differences
T783	3576-3578	IN	denotes	in
T784	3579-3590	JJ	denotes	intraocular
T786	3591-3599	NN	denotes	pressure
T785	3600-3606	NNS	denotes	levels
T787	3607-3614	IN	denotes	between
T788	3615-3619	CD	denotes	four
T790	3620-3625	NN	denotes	mouse
T789	3626-3633	NNS	denotes	strains
T791	3633-3634	.	denotes	.
T792	3634-3804	sentence	denotes	Here, we provide an update, including an extensive strain survey, and show that the methodology is reliable and produces reproducible data over extended periods of time.
T793	3635-3639	RB	denotes	Here
T795	3639-3641	,	denotes	,
T796	3641-3643	PRP	denotes	we
T794	3644-3651	VBP	denotes	provide
T797	3652-3654	DT	denotes	an
T798	3655-3661	NN	denotes	update
T799	3661-3663	,	denotes	,
T800	3663-3672	VBG	denotes	including
T801	3673-3675	DT	denotes	an
T803	3676-3685	JJ	denotes	extensive
T804	3686-3692	NN	denotes	strain
T802	3693-3699	NN	denotes	survey
T805	3699-3701	,	denotes	,
T806	3701-3704	CC	denotes	and
T807	3705-3709	VBP	denotes	show
T808	3710-3714	IN	denotes	that
T810	3715-3718	DT	denotes	the
T811	3719-3730	NN	denotes	methodology
T809	3731-3733	VBZ	denotes	is
T812	3734-3742	JJ	denotes	reliable
T813	3743-3746	CC	denotes	and
T814	3747-3755	VBZ	denotes	produces
T815	3756-3768	JJ	denotes	reproducible
T816	3769-3773	NNS	denotes	data
T817	3774-3778	IN	denotes	over
T818	3779-3787	VBN	denotes	extended
T819	3788-3795	NNS	denotes	periods
T820	3796-3798	IN	denotes	of
T821	3799-3803	NN	denotes	time
T822	3803-3804	.	denotes	.
T894	3815-3816	DT	denotes	A
T896	3817-3822	JJ	denotes	broad
T895	3823-3828	NN	denotes	range
T897	3829-3831	IN	denotes	of
T898	3832-3836	NNS	denotes	IOPs
T899	3837-3844	IN	denotes	between
T900	3845-3852	NNS	denotes	strains
T901	3852-3974	sentence	denotes	Figure 1 shows the average IOP of a number of inbred mouse strains that were housed in the same environmental conditions.
T902	3853-3859	NN	denotes	Figure
T904	3860-3861	CD	denotes	1
T903	3862-3867	VBZ	denotes	shows
T905	3868-3871	DT	denotes	the
T907	3872-3879	JJ	denotes	average
T906	3880-3883	NN	denotes	IOP
T908	3884-3886	IN	denotes	of
T909	3887-3888	DT	denotes	a
T910	3889-3895	NN	denotes	number
T911	3896-3898	IN	denotes	of
T912	3899-3905	JJ	denotes	inbred
T914	3906-3911	NN	denotes	mouse
T913	3912-3919	NNS	denotes	strains
T915	3920-3924	WDT	denotes	that
T917	3925-3929	VBD	denotes	were
T916	3930-3936	VBN	denotes	housed
T918	3937-3939	IN	denotes	in
T919	3940-3943	DT	denotes	the
T921	3944-3948	JJ	denotes	same
T922	3949-3962	JJ	denotes	environmental
T920	3963-3973	NNS	denotes	conditions
T923	3973-3974	.	denotes	.
T924	3974-4141	sentence	denotes	There is a wide range of IOP with strain BALB/cJ having one of the lowest average IOPs (11.1 ± 0.5 mmHg) and strain CBA/CaJ one of the highest IOPs (19.3 ± 0.3 mmHg).
T925	3975-3980	EX	denotes	There
T926	3981-3983	VBZ	denotes	is
T927	3984-3985	DT	denotes	a
T929	3986-3990	JJ	denotes	wide
T928	3991-3996	NN	denotes	range
T930	3997-3999	IN	denotes	of
T931	4000-4003	NN	denotes	IOP
T932	4004-4008	IN	denotes	with
T933	4009-4015	NN	denotes	strain
T935	4016-4020	NN	denotes	BALB
T936	4020-4021	HYPH	denotes	/
T934	4021-4023	NN	denotes	cJ
T937	4024-4030	VBG	denotes	having
T938	4031-4034	CD	denotes	one
T939	4035-4037	IN	denotes	of
T940	4038-4041	DT	denotes	the
T942	4042-4048	JJS	denotes	lowest
T943	4049-4056	JJ	denotes	average
T941	4057-4061	NNS	denotes	IOPs
T944	4062-4063	-LRB-	denotes	(
T945	4063-4067	CD	denotes	11.1
T947	4068-4069	SYM	denotes	±
T946	4070-4073	CD	denotes	0.5
T948	4074-4078	NN	denotes	mmHg
T949	4078-4079	-RRB-	denotes	)
T950	4080-4083	CC	denotes	and
T951	4084-4090	NN	denotes	strain
T953	4091-4094	NN	denotes	CBA
T954	4094-4095	HYPH	denotes	/
T952	4095-4098	NN	denotes	CaJ
T955	4099-4102	CD	denotes	one
T956	4103-4105	IN	denotes	of
T957	4106-4109	DT	denotes	the
T959	4110-4117	JJS	denotes	highest
T958	4118-4122	NNS	denotes	IOPs
T960	4123-4124	-LRB-	denotes	(
T961	4124-4128	CD	denotes	19.3
T963	4129-4130	SYM	denotes	±
T962	4131-4134	CD	denotes	0.3
T964	4135-4139	NN	denotes	mmHg
T965	4139-4140	-RRB-	denotes	)
T966	4140-4141	.	denotes	.
T967	4141-4269	sentence	denotes	Significant differences exist among various strains (P < 0.0001 for all groups, ANOVA comparing strains within each sex group).
T968	4142-4153	JJ	denotes	Significant
T969	4154-4165	NNS	denotes	differences
T970	4166-4171	VBP	denotes	exist
T971	4172-4177	IN	denotes	among
T972	4178-4185	JJ	denotes	various
T973	4186-4193	NNS	denotes	strains
T974	4194-4195	-LRB-	denotes	(
T976	4195-4196	NN	denotes	P
T978	4197-4198	SYM	denotes	<
T977	4199-4205	CD	denotes	0.0001
T979	4206-4209	IN	denotes	for
T980	4210-4213	DT	denotes	all
T981	4214-4220	NNS	denotes	groups
T982	4220-4222	,	denotes	,
T975	4222-4227	NN	denotes	ANOVA
T983	4228-4237	VBG	denotes	comparing
T984	4238-4245	NNS	denotes	strains
T985	4246-4252	IN	denotes	within
T986	4253-4257	DT	denotes	each
T988	4258-4261	NN	denotes	sex
T987	4262-4267	NN	denotes	group
T989	4267-4268	-RRB-	denotes	)
T990	4268-4269	.	denotes	.
T991	4269-5001	sentence	denotes	Figure 1 An almost two-fold range of IOP between genetically distinct mouse strains. Mean IOP ± SEM is shown for each strain. Twelve to 25 mice were analyzed for each strain (typically 18 to 20), except for RIIIS/J (7 mice). Mice of most strains were 6 to 12 months old, except for SEC/1ReJ and SB/Le that were 2 to 3 months old. Approximately half of the CE/J and one third of the BUB/BnJ mice were 16 months old and were pooled with the younger mice, as the IOPs of both ages were the same. Strain name CBA/CaHN-Btkxid/J is abbreviated to CBA/CaHN. Clinical and histological analysis of the eyes of all studied strains (see Table 1) did not identify anatomic or pathologic features that might account for the differences in IOP.
T7658	4280-4282	DT	denotes	An
T7660	4283-4289	RB	denotes	almost
T7661	4290-4298	JJ	denotes	two-fold
T7659	4299-4304	NN	denotes	range
T7662	4305-4307	IN	denotes	of
T7663	4308-4311	NN	denotes	IOP
T7664	4312-4319	IN	denotes	between
T7665	4320-4331	RB	denotes	genetically
T7666	4332-4340	JJ	denotes	distinct
T7668	4341-4346	NN	denotes	mouse
T7667	4347-4354	NNS	denotes	strains
T7669	4354-4355	.	denotes	.
T7670	4355-4396	sentence	denotes	Mean IOP ± SEM is shown for each strain.
T7671	4356-4360	JJ	denotes	Mean
T7672	4361-4364	NN	denotes	IOP
T7674	4365-4366	SYM	denotes	±
T7675	4367-4370	NN	denotes	SEM
T7676	4371-4373	VBZ	denotes	is
T7673	4374-4379	VBN	denotes	shown
T7677	4380-4383	IN	denotes	for
T7678	4384-4388	DT	denotes	each
T7679	4389-4395	NN	denotes	strain
T7680	4395-4396	.	denotes	.
T7681	4396-4495	sentence	denotes	Twelve to 25 mice were analyzed for each strain (typically 18 to 20), except for RIIIS/J (7 mice).
T7682	4397-4403	CD	denotes	Twelve
T7684	4404-4406	IN	denotes	to
T7683	4407-4409	CD	denotes	25
T7685	4410-4414	NNS	denotes	mice
T7687	4415-4419	VBD	denotes	were
T7686	4420-4428	VBN	denotes	analyzed
T7688	4429-4432	IN	denotes	for
T7689	4433-4437	DT	denotes	each
T7690	4438-4444	NN	denotes	strain
T7691	4445-4446	-LRB-	denotes	(
T7693	4446-4455	RB	denotes	typically
T7694	4456-4458	CD	denotes	18
T7695	4459-4461	IN	denotes	to
T7692	4462-4464	CD	denotes	20
T7696	4464-4465	-RRB-	denotes	)
T7697	4465-4467	,	denotes	,
T7698	4467-4473	IN	denotes	except
T7699	4474-4477	IN	denotes	for
T7700	4478-4483	NN	denotes	RIIIS
T7702	4483-4484	HYPH	denotes	/
T7701	4484-4485	NN	denotes	J
T7703	4486-4487	-LRB-	denotes	(
T7705	4487-4488	CD	denotes	7
T7704	4489-4493	NNS	denotes	mice
T7706	4493-4494	-RRB-	denotes	)
T7707	4494-4495	.	denotes	.
T7708	4495-4600	sentence	denotes	Mice of most strains were 6 to 12 months old, except for SEC/1ReJ and SB/Le that were 2 to 3 months old.
T7709	4496-4500	NNS	denotes	Mice
T7711	4501-4503	IN	denotes	of
T7712	4504-4508	JJS	denotes	most
T7713	4509-4516	NNS	denotes	strains
T7710	4517-4521	VBD	denotes	were
T7714	4522-4523	CD	denotes	6
T7716	4524-4526	IN	denotes	to
T7715	4527-4529	CD	denotes	12
T7717	4530-4536	NNS	denotes	months
T7718	4537-4540	JJ	denotes	old
T7719	4540-4542	,	denotes	,
T7720	4542-4548	IN	denotes	except
T7721	4549-4552	IN	denotes	for
T7722	4553-4556	NN	denotes	SEC
T7724	4556-4557	HYPH	denotes	/
T7723	4557-4561	NN	denotes	1ReJ
T7725	4562-4565	CC	denotes	and
T7726	4566-4568	NN	denotes	SB
T7728	4568-4569	HYPH	denotes	/
T7727	4569-4571	NN	denotes	Le
T7729	4572-4576	WDT	denotes	that
T7730	4577-4581	VBD	denotes	were
T7731	4582-4583	CD	denotes	2
T7733	4584-4586	IN	denotes	to
T7732	4587-4588	CD	denotes	3
T7734	4589-4595	NNS	denotes	months
T7735	4596-4599	JJ	denotes	old
T7736	4599-4600	.	denotes	.
T7737	4600-4763	sentence	denotes	Approximately half of the CE/J and one third of the BUB/BnJ mice were 16 months old and were pooled with the younger mice, as the IOPs of both ages were the same.
T7738	4601-4614	RB	denotes	Approximately
T7739	4615-4619	NN	denotes	half
T7741	4620-4622	IN	denotes	of
T7742	4623-4626	DT	denotes	the
T7744	4627-4629	NN	denotes	CE
T7745	4629-4630	HYPH	denotes	/
T7743	4630-4631	NN	denotes	J
T7746	4632-4635	CC	denotes	and
T7747	4636-4639	CD	denotes	one
T7749	4640-4645	NN	denotes	third
T7750	4646-4648	IN	denotes	of
T7751	4649-4652	DT	denotes	the
T7753	4653-4656	NN	denotes	BUB
T7754	4656-4657	HYPH	denotes	/
T7752	4657-4660	NN	denotes	BnJ
T7748	4661-4665	NNS	denotes	mice
T7740	4666-4670	VBD	denotes	were
T7755	4671-4673	CD	denotes	16
T7756	4674-4680	NNS	denotes	months
T7757	4681-4684	JJ	denotes	old
T7758	4685-4688	CC	denotes	and
T7759	4689-4693	VBD	denotes	were
T7760	4694-4700	VBN	denotes	pooled
T7761	4701-4705	IN	denotes	with
T7762	4706-4709	DT	denotes	the
T7764	4710-4717	JJR	denotes	younger
T7763	4718-4722	NNS	denotes	mice
T7765	4722-4724	,	denotes	,
T7766	4724-4726	IN	denotes	as
T7768	4727-4730	DT	denotes	the
T7769	4731-4735	NNS	denotes	IOPs
T7770	4736-4738	IN	denotes	of
T7771	4739-4743	DT	denotes	both
T7772	4744-4748	NNS	denotes	ages
T7767	4749-4753	VBD	denotes	were
T7773	4754-4757	DT	denotes	the
T7774	4758-4762	JJ	denotes	same
T7775	4762-4763	.	denotes	.
T7776	4763-4821	sentence	denotes	Strain name CBA/CaHN-Btkxid/J is abbreviated to CBA/CaHN.
T7777	4764-4770	NN	denotes	Strain
T7779	4771-4775	NN	denotes	name
T7780	4776-4779	NN	denotes	CBA
T7782	4779-4780	HYPH	denotes	/
T7781	4780-4784	NN	denotes	CaHN
T7783	4784-4785	HYPH	denotes	-
T7784	4785-4791	NN	denotes	Btkxid
T7785	4791-4792	HYPH	denotes	/
T7778	4792-4793	NN	denotes	J
T7787	4794-4796	VBZ	denotes	is
T7786	4797-4808	VBN	denotes	abbreviated
T7788	4809-4811	IN	denotes	to
T7789	4812-4815	NN	denotes	CBA
T7791	4815-4816	HYPH	denotes	/
T7790	4816-4820	NN	denotes	CaHN
T7792	4820-4821	.	denotes	.
T992	4822-4830	JJ	denotes	Clinical
T994	4831-4834	CC	denotes	and
T995	4835-4847	JJ	denotes	histological
T993	4848-4856	NN	denotes	analysis
T997	4857-4859	IN	denotes	of
T998	4860-4863	DT	denotes	the
T999	4864-4868	NNS	denotes	eyes
T1000	4869-4871	IN	denotes	of
T1001	4872-4875	DT	denotes	all
T1003	4876-4883	JJ	denotes	studied
T1002	4884-4891	NNS	denotes	strains
T1004	4892-4893	-LRB-	denotes	(
T1005	4893-4896	VB	denotes	see
T1006	4897-4902	NN	denotes	Table
T1007	4903-4904	CD	denotes	1
T1008	4904-4905	-RRB-	denotes	)
T1009	4906-4909	VBD	denotes	did
T1010	4910-4913	RB	denotes	not
T996	4914-4922	VB	denotes	identify
T1011	4923-4931	JJ	denotes	anatomic
T1013	4932-4934	CC	denotes	or
T1014	4935-4945	JJ	denotes	pathologic
T1012	4946-4954	NNS	denotes	features
T1015	4955-4959	WDT	denotes	that
T1017	4960-4965	MD	denotes	might
T1016	4966-4973	VB	denotes	account
T1018	4974-4977	IN	denotes	for
T1019	4978-4981	DT	denotes	the
T1020	4982-4993	NNS	denotes	differences
T1021	4994-4996	IN	denotes	in
T1022	4997-5000	NN	denotes	IOP
T1023	5000-5001	.	denotes	.
T1024	5001-5180	sentence	denotes	For example, the iridocorneal angle and aqueous humor drainage structures are open to the anterior chamber and have normal morphology in both BALB/cJ and CBA/CaJ mice (Figure 2).
T1025	5002-5005	IN	denotes	For
T1027	5006-5013	NN	denotes	example
T1028	5013-5015	,	denotes	,
T1029	5015-5018	DT	denotes	the
T1031	5019-5031	JJ	denotes	iridocorneal
T1030	5032-5037	NN	denotes	angle
T1032	5038-5041	CC	denotes	and
T1033	5042-5049	JJ	denotes	aqueous
T1034	5050-5055	NN	denotes	humor
T1035	5056-5064	NN	denotes	drainage
T1036	5065-5075	NNS	denotes	structures
T1026	5076-5079	VBP	denotes	are
T1037	5080-5084	JJ	denotes	open
T1038	5085-5087	IN	denotes	to
T1039	5088-5091	DT	denotes	the
T1041	5092-5100	JJ	denotes	anterior
T1040	5101-5108	NN	denotes	chamber
T1042	5109-5112	CC	denotes	and
T1043	5113-5117	VBP	denotes	have
T1044	5118-5124	JJ	denotes	normal
T1045	5125-5135	NN	denotes	morphology
T1046	5136-5138	IN	denotes	in
T1047	5139-5143	CC	denotes	both
T1049	5144-5148	NN	denotes	BALB
T1050	5148-5149	HYPH	denotes	/
T1048	5149-5151	NN	denotes	cJ
T1052	5152-5155	CC	denotes	and
T1053	5156-5159	NN	denotes	CBA
T1055	5159-5160	HYPH	denotes	/
T1054	5160-5163	NN	denotes	CaJ
T1051	5164-5168	NNS	denotes	mice
T1056	5169-5170	-LRB-	denotes	(
T1057	5170-5176	NN	denotes	Figure
T1058	5177-5178	CD	denotes	2
T1059	5178-5179	-RRB-	denotes	)
T1060	5179-5180	.	denotes	.
T1061	5180-5281	sentence	denotes	More than 20% of CBA/CaJ mice had IOPs of over 21 mmHg, which increases risk for glaucoma in humans.
T1062	5181-5185	JJR	denotes	More
T1064	5186-5190	IN	denotes	than
T1063	5191-5193	CD	denotes	20
T1065	5193-5194	NN	denotes	%
T1067	5195-5197	IN	denotes	of
T1068	5198-5201	NN	denotes	CBA
T1070	5201-5202	HYPH	denotes	/
T1069	5202-5205	NN	denotes	CaJ
T1071	5206-5210	NNS	denotes	mice
T1066	5211-5214	VBD	denotes	had
T1072	5215-5219	NNS	denotes	IOPs
T1073	5220-5222	IN	denotes	of
T1074	5223-5227	IN	denotes	over
T1075	5228-5230	CD	denotes	21
T1076	5231-5235	NN	denotes	mmHg
T1077	5235-5237	,	denotes	,
T1078	5237-5242	WDT	denotes	which
T1079	5243-5252	VBZ	denotes	increases
T1080	5253-5257	NN	denotes	risk
T1081	5258-5261	IN	denotes	for
T1082	5262-5270	NN	denotes	glaucoma
T1083	5271-5273	IN	denotes	in
T1084	5274-5280	NNS	denotes	humans
T1085	5280-5281	.	denotes	.
T1086	5281-5430	sentence	denotes	We aged a small group of these mice (n = 4) to 2 years and histologically analyzed their optic nerves and retinas but they did not develop glaucoma.
T1087	5282-5284	PRP	denotes	We
T1088	5285-5289	VBD	denotes	aged
T1089	5290-5291	DT	denotes	a
T1091	5292-5297	JJ	denotes	small
T1090	5298-5303	NN	denotes	group
T1092	5304-5306	IN	denotes	of
T1093	5307-5312	DT	denotes	these
T1094	5313-5317	NNS	denotes	mice
T1095	5318-5319	-LRB-	denotes	(
T1097	5319-5320	NN	denotes	n
T1098	5321-5322	SYM	denotes	=
T1096	5323-5324	CD	denotes	4
T1099	5324-5325	-RRB-	denotes	)
T1100	5326-5328	IN	denotes	to
T1101	5329-5330	CD	denotes	2
T1102	5331-5336	NNS	denotes	years
T1103	5337-5340	CC	denotes	and
T1104	5341-5355	RB	denotes	histologically
T1105	5356-5364	VBD	denotes	analyzed
T1106	5365-5370	PRP$	denotes	their
T1108	5371-5376	JJ	denotes	optic
T1107	5377-5383	NNS	denotes	nerves
T1109	5384-5387	CC	denotes	and
T1110	5388-5395	NNS	denotes	retinas
T1111	5396-5399	CC	denotes	but
T1112	5400-5404	PRP	denotes	they
T1114	5405-5408	VBD	denotes	did
T1115	5409-5412	RB	denotes	not
T1113	5413-5420	VB	denotes	develop
T1116	5421-5429	NN	denotes	glaucoma
T1117	5429-5430	.	denotes	.
T7816	5441-5447	JJ	denotes	Normal
T7818	5448-5460	JJ	denotes	iridocorneal
T7817	5461-5467	NNS	denotes	angles
T7819	5468-5470	IN	denotes	in
T7820	5471-5478	NNS	denotes	strains
T7821	5479-5483	IN	denotes	with
T7822	5484-5488	JJ	denotes	high
T7824	5489-5492	CC	denotes	and
T7825	5493-5496	JJ	denotes	low
T7823	5497-5500	NN	denotes	IOP
T7826	5500-5501	.	denotes	.
T7827	5501-5729	sentence	denotes	The iridocorneal angle that contains the aqueous humor drainage structures (Schlemm's canal (SC) and trabecular meshwork (TM) had a normal morphology in strains CBA/CaJ (A, high IOP), BALB/cJ (B, low IOP) and all other strains.
T7828	5502-5505	DT	denotes	The
T7830	5506-5518	JJ	denotes	iridocorneal
T7829	5519-5524	NN	denotes	angle
T7832	5525-5529	WDT	denotes	that
T7833	5530-5538	VBZ	denotes	contains
T7834	5539-5542	DT	denotes	the
T7836	5543-5550	JJ	denotes	aqueous
T7837	5551-5556	NN	denotes	humor
T7838	5557-5565	NN	denotes	drainage
T7835	5566-5576	NNS	denotes	structures
T7839	5577-5578	-LRB-	denotes	(
T7840	5578-5585	NNP	denotes	Schlemm
T7842	5585-5587	POS	denotes	's
T7841	5588-5593	NN	denotes	canal
T7843	5594-5595	-LRB-	denotes	(
T7844	5595-5597	NN	denotes	SC
T7845	5597-5598	-RRB-	denotes	)
T7846	5599-5602	CC	denotes	and
T7847	5603-5613	JJ	denotes	trabecular
T7848	5614-5622	NN	denotes	meshwork
T7849	5623-5624	-LRB-	denotes	(
T7850	5624-5626	NN	denotes	TM
T7851	5626-5627	-RRB-	denotes	)
T7831	5628-5631	VBD	denotes	had
T7852	5632-5633	DT	denotes	a
T7854	5634-5640	JJ	denotes	normal
T7853	5641-5651	NN	denotes	morphology
T7855	5652-5654	IN	denotes	in
T7856	5655-5662	NNS	denotes	strains
T7858	5663-5666	NN	denotes	CBA
T7859	5666-5667	HYPH	denotes	/
T7857	5667-5670	NN	denotes	CaJ
T7860	5671-5672	-LRB-	denotes	(
T7862	5672-5673	NN	denotes	A
T7863	5673-5675	,	denotes	,
T7864	5675-5679	JJ	denotes	high
T7861	5680-5683	NN	denotes	IOP
T7865	5683-5684	-RRB-	denotes	)
T7866	5684-5686	,	denotes	,
T7867	5686-5690	NN	denotes	BALB
T7869	5690-5691	HYPH	denotes	/
T7868	5691-5693	NN	denotes	cJ
T7870	5694-5695	-LRB-	denotes	(
T7872	5695-5696	NN	denotes	B
T7873	5696-5698	,	denotes	,
T7874	5698-5701	JJ	denotes	low
T7871	5702-5705	NN	denotes	IOP
T7875	5705-5706	-RRB-	denotes	)
T7876	5707-5710	CC	denotes	and
T7877	5711-5714	DT	denotes	all
T7879	5715-5720	JJ	denotes	other
T7878	5721-5728	NNS	denotes	strains
T7880	5728-5729	.	denotes	.
T7881	5729-5881	sentence	denotes	Pigment filled macrophages that resemble human clump cells were often located in the angle of CBA/CaJ mice but were never sufficient to block drainage.
T7882	5730-5737	NN	denotes	Pigment
T7883	5738-5744	VBN	denotes	filled
T7884	5745-5756	NNS	denotes	macrophages
T7886	5757-5761	WDT	denotes	that
T7887	5762-5770	VBP	denotes	resemble
T7888	5771-5776	JJ	denotes	human
T7890	5777-5782	NN	denotes	clump
T7889	5783-5788	NNS	denotes	cells
T7891	5789-5793	VBD	denotes	were
T7892	5794-5799	RB	denotes	often
T7885	5800-5807	VBN	denotes	located
T7893	5808-5810	IN	denotes	in
T7894	5811-5814	DT	denotes	the
T7895	5815-5820	NN	denotes	angle
T7896	5821-5823	IN	denotes	of
T7897	5824-5827	NN	denotes	CBA
T7899	5827-5828	HYPH	denotes	/
T7898	5828-5831	NN	denotes	CaJ
T7900	5832-5836	NNS	denotes	mice
T7901	5837-5840	CC	denotes	but
T7902	5841-5845	VBD	denotes	were
T7903	5846-5851	RB	denotes	never
T7904	5852-5862	JJ	denotes	sufficient
T7905	5863-5865	TO	denotes	to
T7906	5866-5871	VB	denotes	block
T7907	5872-5880	NN	denotes	drainage
T7908	5880-5881	.	denotes	.
T7909	5881-5982	sentence	denotes	We have observed similar quantities of these cells at this location in other strains with lower IOP.
T7910	5882-5884	PRP	denotes	We
T7912	5885-5889	VBP	denotes	have
T7911	5890-5898	VBN	denotes	observed
T7913	5899-5906	JJ	denotes	similar
T7914	5907-5917	NNS	denotes	quantities
T7915	5918-5920	IN	denotes	of
T7916	5921-5926	DT	denotes	these
T7917	5927-5932	NNS	denotes	cells
T7918	5933-5935	IN	denotes	at
T7919	5936-5940	DT	denotes	this
T7920	5941-5949	NN	denotes	location
T7921	5950-5952	IN	denotes	in
T7922	5953-5958	JJ	denotes	other
T7923	5959-5966	NNS	denotes	strains
T7924	5967-5971	IN	denotes	with
T7925	5972-5977	JJR	denotes	lower
T7926	5978-5981	NN	denotes	IOP
T7927	5981-5982	.	denotes	.
T7928	5982-6067	sentence	denotes	The angle recess between the cornea (C) and iris root (I) was open and not occluded.
T7929	5983-5986	DT	denotes	The
T7931	5987-5992	JJ	denotes	angle
T7930	5993-5999	NN	denotes	recess
T7933	6000-6007	IN	denotes	between
T7934	6008-6011	DT	denotes	the
T7935	6012-6018	NN	denotes	cornea
T7936	6019-6020	-LRB-	denotes	(
T7937	6020-6021	NN	denotes	C
T7938	6021-6022	-RRB-	denotes	)
T7939	6023-6026	CC	denotes	and
T7940	6027-6031	NN	denotes	iris
T7941	6032-6036	NN	denotes	root
T7942	6037-6038	-LRB-	denotes	(
T7945	6038-6039	NN	denotes	I
T7946	6039-6040	-RRB-	denotes	)
T7932	6041-6044	VBD	denotes	was
T7949	6045-6049	JJ	denotes	open
T7950	6050-6053	CC	denotes	and
T7951	6054-6057	RB	denotes	not
T7952	6058-6066	JJ	denotes	occluded
T7953	6066-6067	.	denotes	.
T7954	6067-6149	sentence	denotes	Aqueous humor passes through this recess before entering the drainage structures.
T7955	6068-6075	JJ	denotes	Aqueous
T7956	6076-6081	NN	denotes	humor
T7957	6082-6088	VBZ	denotes	passes
T7958	6089-6096	IN	denotes	through
T7959	6097-6101	DT	denotes	this
T7960	6102-6108	NN	denotes	recess
T7961	6109-6115	IN	denotes	before
T7962	6116-6124	VBG	denotes	entering
T7963	6125-6128	DT	denotes	the
T7965	6129-6137	NN	denotes	drainage
T7964	6138-6148	NNS	denotes	structures
T7943	6148-6149	.	denotes	.
T7944	6149-6178	sentence	denotes	Original Magnification 630X.
T7947	6150-6158	JJ	denotes	Original
T7948	6159-6172	NN	denotes	Magnification
T7966	6173-6177	NNS	denotes	630X
T7967	6177-6178	.	denotes	.
T9484	6188-6194	JJ	denotes	Ocular
T9485	6195-6208	NNS	denotes	abnormalities
T9486	6209-6211	IN	denotes	in
T9487	6212-6219	JJ	denotes	various
T9488	6220-6227	NNS	denotes	strains
T1150	7621-7627	NN	denotes	Strain
T1151	7628-7639	NNS	denotes	differences
T1152	7640-7643	VBP	denotes	are
T1153	7644-7656	JJ	denotes	reproducible
T1154	7656-7818	sentence	denotes	To assess the consistency of IOP in specific strains, we measured IOP in different cohorts of each strain maintained under similar conditions at different times.
T1155	7657-7659	TO	denotes	To
T1156	7660-7666	VB	denotes	assess
T1158	7667-7670	DT	denotes	the
T1159	7671-7682	NN	denotes	consistency
T1160	7683-7685	IN	denotes	of
T1161	7686-7689	NN	denotes	IOP
T1162	7690-7692	IN	denotes	in
T1163	7693-7701	JJ	denotes	specific
T1164	7702-7709	NNS	denotes	strains
T1165	7709-7711	,	denotes	,
T1166	7711-7713	PRP	denotes	we
T1157	7714-7722	VBD	denotes	measured
T1167	7723-7726	NN	denotes	IOP
T1168	7727-7729	IN	denotes	in
T1169	7730-7739	JJ	denotes	different
T1170	7740-7747	NNS	denotes	cohorts
T1171	7748-7750	IN	denotes	of
T1172	7751-7755	DT	denotes	each
T1173	7756-7762	NN	denotes	strain
T1174	7763-7773	VBN	denotes	maintained
T1175	7774-7779	IN	denotes	under
T1176	7780-7787	JJ	denotes	similar
T1177	7788-7798	NNS	denotes	conditions
T1178	7799-7801	IN	denotes	at
T1179	7802-7811	JJ	denotes	different
T1180	7812-7817	NNS	denotes	times
T1181	7817-7818	.	denotes	.
T1182	7818-7967	sentence	denotes	We purposefully included strains at each end of the IOP spectrum, and strain C57BL/6J (B6) that is commonly used for genetic experiments (Figure 3).
T1183	7819-7821	PRP	denotes	We
T1185	7822-7834	RB	denotes	purposefully
T1184	7835-7843	VBD	denotes	included
T1186	7844-7851	NNS	denotes	strains
T1187	7852-7854	IN	denotes	at
T1188	7855-7859	DT	denotes	each
T1189	7860-7863	NN	denotes	end
T1190	7864-7866	IN	denotes	of
T1191	7867-7870	DT	denotes	the
T1193	7871-7874	NN	denotes	IOP
T1192	7875-7883	NN	denotes	spectrum
T1194	7883-7885	,	denotes	,
T1195	7885-7888	CC	denotes	and
T1196	7889-7895	NN	denotes	strain
T1198	7896-7901	NN	denotes	C57BL
T1199	7901-7902	HYPH	denotes	/
T1197	7902-7904	NN	denotes	6J
T1200	7905-7906	-LRB-	denotes	(
T1201	7906-7908	NN	denotes	B6
T1202	7908-7909	-RRB-	denotes	)
T1203	7910-7914	WDT	denotes	that
T1205	7915-7917	VBZ	denotes	is
T1206	7918-7926	RB	denotes	commonly
T1204	7927-7931	VBN	denotes	used
T1207	7932-7935	IN	denotes	for
T1208	7936-7943	JJ	denotes	genetic
T1209	7944-7955	NNS	denotes	experiments
T1210	7956-7957	-LRB-	denotes	(
T1211	7957-7963	NN	denotes	Figure
T1212	7964-7965	CD	denotes	3
T1213	7965-7966	-RRB-	denotes	)
T1214	7966-7967	.	denotes	.
T1215	7967-8095	sentence	denotes	The average IOP of different cohorts of strains CBA/CaJ, CBA/CaHN (both high end of spectrum) and B6 were consistent over time.
T1216	7968-7971	DT	denotes	The
T1218	7972-7979	JJ	denotes	average
T1217	7980-7983	NN	denotes	IOP
T1220	7984-7986	IN	denotes	of
T1221	7987-7996	JJ	denotes	different
T1222	7997-8004	NNS	denotes	cohorts
T1223	8005-8007	IN	denotes	of
T1224	8008-8015	NNS	denotes	strains
T1226	8016-8019	NN	denotes	CBA
T1227	8019-8020	HYPH	denotes	/
T1225	8020-8023	NN	denotes	CaJ
T1228	8023-8025	,	denotes	,
T1229	8025-8028	NN	denotes	CBA
T1231	8028-8029	HYPH	denotes	/
T1230	8029-8033	NN	denotes	CaHN
T1232	8034-8035	-LRB-	denotes	(
T1233	8035-8039	DT	denotes	both
T1234	8040-8044	JJ	denotes	high
T1235	8045-8048	NN	denotes	end
T1236	8049-8051	IN	denotes	of
T1237	8052-8060	NN	denotes	spectrum
T1238	8060-8061	-RRB-	denotes	)
T1239	8062-8065	CC	denotes	and
T1240	8066-8068	NN	denotes	B6
T1219	8069-8073	VBD	denotes	were
T1241	8074-8084	JJ	denotes	consistent
T1242	8085-8089	IN	denotes	over
T1243	8090-8094	NN	denotes	time
T1244	8094-8095	.	denotes	.
T1245	8095-8157	sentence	denotes	This was true of most strains assessed on multiple occasions.
T1246	8096-8100	DT	denotes	This
T1247	8101-8104	VBD	denotes	was
T1248	8105-8109	JJ	denotes	true
T1249	8110-8112	IN	denotes	of
T1250	8113-8117	JJS	denotes	most
T1251	8118-8125	NNS	denotes	strains
T1252	8126-8134	VBN	denotes	assessed
T1253	8135-8137	IN	denotes	on
T1254	8138-8146	JJ	denotes	multiple
T1255	8147-8156	NNS	denotes	occasions
T1256	8156-8157	.	denotes	.
T1257	8157-8324	sentence	denotes	Average IOP for age matched mice of the same strain assessed at different times typically differed by no more than 1.5 mmHg, and the differences were usually smaller.
T1258	8158-8165	JJ	denotes	Average
T1259	8166-8169	NN	denotes	IOP
T1261	8170-8173	IN	denotes	for
T1262	8174-8177	NN	denotes	age
T1263	8178-8185	VBN	denotes	matched
T1264	8186-8190	NNS	denotes	mice
T1265	8191-8193	IN	denotes	of
T1266	8194-8197	DT	denotes	the
T1268	8198-8202	JJ	denotes	same
T1267	8203-8209	NN	denotes	strain
T1269	8210-8218	VBN	denotes	assessed
T1270	8219-8221	IN	denotes	at
T1271	8222-8231	JJ	denotes	different
T1272	8232-8237	NNS	denotes	times
T1273	8238-8247	RB	denotes	typically
T1260	8248-8256	VBN	denotes	differed
T1274	8257-8259	IN	denotes	by
T1275	8260-8262	DT	denotes	no
T1277	8263-8267	JJR	denotes	more
T1278	8268-8272	IN	denotes	than
T1276	8273-8276	CD	denotes	1.5
T1279	8277-8281	NN	denotes	mmHg
T1280	8281-8283	,	denotes	,
T1281	8283-8286	CC	denotes	and
T1282	8287-8290	DT	denotes	the
T1283	8291-8302	NNS	denotes	differences
T1284	8303-8307	VBD	denotes	were
T1285	8308-8315	RB	denotes	usually
T1286	8316-8323	JJR	denotes	smaller
T1287	8323-8324	.	denotes	.
T1288	8324-8420	sentence	denotes	Strain 129P3/J was the most variable strain with the average IOP fluctuating by up to 2.5 mmHg.
T1289	8325-8331	NN	denotes	Strain
T1291	8332-8337	NN	denotes	129P3
T1292	8337-8338	HYPH	denotes	/
T1290	8338-8339	NN	denotes	J
T1293	8340-8343	VBD	denotes	was
T1294	8344-8347	DT	denotes	the
T1296	8348-8352	RBS	denotes	most
T1297	8353-8361	JJ	denotes	variable
T1295	8362-8368	NN	denotes	strain
T1298	8369-8373	IN	denotes	with
T1300	8374-8377	DT	denotes	the
T1302	8378-8385	JJ	denotes	average
T1301	8386-8389	NN	denotes	IOP
T1299	8390-8401	VBG	denotes	fluctuating
T1303	8402-8404	IN	denotes	by
T1304	8405-8407	IN	denotes	up
T1306	8408-8410	IN	denotes	to
T1305	8411-8414	CD	denotes	2.5
T1307	8415-8419	NN	denotes	mmHg
T1308	8419-8420	.	denotes	.
T1309	8420-9468	sentence	denotes	Figure 3 The IOPs of different strains are stable and reproducible over time. Mean IOP ± SEM is shown for the indicated strain at different times of measurement. The measurement times within a single year were separated by a few months. The IOPs of strains that were analyzed multiple times in the same year are listed in the chronological order that they were obtained with the earliest measurement on left. The sex [Male (M) or Female (F)], age (months), and number of mice (n) analyzed for the CBA strains are listed starting with the earliest measurement and ending with the latest: CBA/CaJ, F, n = 22, age 6–7; M, n = 11, age 2; CBA/CaHN, F, n = 16, age 3; M, n = 8, age 3. For BALB/cJ and C57BL/6J, all groups were male and primarily 3 to 4 months old. The number of mice analyzed at each time follows: BALB/cJ 8, 10, 11, 15, 18 and 14, C57BL/6J 10, 14, 21,40,40 and 42. Strain name CBA/CaHN-Btkxid/J is abbreviated to CBA/CaHN. Despite the general consistency of IOP, the average IOPs of some strains have changed in a reproducible manner.
T8009	8431-8434	DT	denotes	The
T8010	8435-8439	NNS	denotes	IOPs
T8012	8440-8442	IN	denotes	of
T8013	8443-8452	JJ	denotes	different
T8014	8453-8460	NNS	denotes	strains
T8011	8461-8464	VBP	denotes	are
T8015	8465-8471	JJ	denotes	stable
T8016	8472-8475	CC	denotes	and
T8017	8476-8488	JJ	denotes	reproducible
T8018	8489-8493	IN	denotes	over
T8019	8494-8498	NN	denotes	time
T8020	8498-8499	.	denotes	.
T8021	8499-8583	sentence	denotes	Mean IOP ± SEM is shown for the indicated strain at different times of measurement.
T8640	8500-8504	NN	denotes	Mean
T8022	8500-8504	NN	denotes	Mean
T8273	8500-8504	NN	denotes	Mean
T8641	8505-8508	NN	denotes	IOP
T8023	8505-8508	NN	denotes	IOP
T8274	8505-8508	NN	denotes	IOP
T8643	8509-8510	SYM	denotes	±
T8025	8509-8510	SYM	denotes	±
T8276	8509-8510	SYM	denotes	±
T8644	8511-8514	NN	denotes	SEM
T8026	8511-8514	NN	denotes	SEM
T8277	8511-8514	NN	denotes	SEM
T8645	8515-8517	VBZ	denotes	is
T8027	8515-8517	VBZ	denotes	is
T8278	8515-8517	VBZ	denotes	is
T8642	8518-8523	VBN	denotes	shown
T8024	8518-8523	VBN	denotes	shown
T8275	8518-8523	VBN	denotes	shown
T8646	8524-8527	IN	denotes	for
T8028	8524-8527	IN	denotes	for
T8279	8524-8527	IN	denotes	for
T8647	8528-8531	DT	denotes	the
T8029	8528-8531	DT	denotes	the
T8280	8528-8531	DT	denotes	the
T8649	8532-8541	VBN	denotes	indicated
T8031	8532-8541	VBN	denotes	indicated
T8282	8532-8541	VBN	denotes	indicated
T8030	8542-8548	NN	denotes	strain
T8281	8542-8548	NN	denotes	strain
T8648	8542-16202	NNS	denotes	strain at different times of measurement. The measurement times within a single year were separated by a few months. The IOPs of strains that were analyzed multiple times in the same year are listed in the chronological order that they were obtained with the earliest measurement on left. The sex [Male (M) or Female (F)], age (months), and number of mice (n) analyzed for the CBA strains are listed starting with the earliest measurement and ending with the latest: CBA/CaJ, F, n = 22, age 6–7; M, n = 11, age 2; CBA/CaHN, F, n = 16, age 3; M, n = 8, age 3. For BALB/cJ and C57BL/6J, all groups were male and primarily 3 to 4 months old. The number of mice analyzed at each time follows: BALB/cJ 8, 10, 11, 15, 18 and 14, C57BL/6J 10, 14, 21,40,40 and 42. Strain name CBA/CaHN-Btkxid/J is abbreviated to CBA/CaHN. Despite the general consistency of IOP, the average IOPs of some strains have changed in a reproducible manner. The IOPs of BALB/cJ mice (low end of spectrum) were very similar for the past several years, around 11 mmHg. Between early 1996 and 1997, however, the IOP of this strain did jump from approximately 7.7 mmHg to approximately 11 mmHg (Figure 3). During this period, the room in which our animals were housed and the manufacturer of the mouse diet were changed. Over the same period, the IOP of A/J also increased dramatically, from 9.4 ± 0.5 mmHg (n = 11) in 1996 to 14.2 ± 0.4 mmHg (n = 19) in 1997. The increased IOP in A/J also was reproducible, with the average IOP of mice assessed in the year 2000 being 14.5 ± 0.4 mmHg (n = 16). Importantly, the IOPs of strains B6 and C3H/HeJ did not change during this time (B6, 12.3. ± 0.5 mmHg in 1996 and 12.4 ± 0.3 mmHg in 1997, n= 10 and 14; C3H/HeJ, 13.7 ± 0.8 mmHg in 1996 and 13.6 ± 0.2 mmHg in 1997, n = 9 and 19). Effect of age on IOP We focused on the commonly used B6, 129P3/J and C3H/HeJ strains to determine the effects of age on IOP (Figure 4). In B6, age had a significant effect on IOP (P < 0.001). IOP was slightly decreased at both 12 months (12.2 ± 0.2 mmHg) and 19 months (12.2 ± 0.3 mmHg) compared to 3 months (13.1 ± 0.3 mmHg) and 7 months (13.3 ± 0.3 mmHg). Although the decrease was of a similar level to the variation observed in 3 month old mice (see Figure 3), the IOPs of control young mice (see Methods) analyzed at the same times as the various B6 age groups did not decrease. For example, control mice analyzed at the same time as the 3 month, 12 month and 18 month B6 age groups had IOPs of 13.0 ± 0.2 mmHg (n = 14), 13.3 ± 0.2 mmHg (n = 14), 13.7 ± 0.4 mmHg (n = 12), respectively. IOP was even lower in the 24 month B6 mice (10.8 ± 0.4 mmHg), and again the average IOP of young controls measured at the same time was not changed (13.5 ± 0.2, n = 12). Figure 4 IOP changes with increasing Age. Mean IOP ± SEM is shown for the indicated strain at different ages. IOP decreased significantly in strains C57BL/6J and 129P3/J but not C3H/HeJ. The C57BL/6J and 129P3/J groups consisted of approximately equal numbers of males and females. The 3 months old C3H/HeJ mice were male while the other ages were composed of males and females. The number of mice analyzed at each age, listed from youngest to oldest, follow: C57BL/6J, 18, 18, 18, 18, 13; 129P3/J, 18, 15, 16, 14, 21; C3H/HeJ, 15, 23 17 and 16. In strain 129P3/J, IOP did not differ significantly with age between 3 and 14 months but was lower in 18 month old mice (P < 0.001 compared to all younger ages, Figure 4). Despite a 1 mmHg dip in IOP at 8 months, there were no significant IOP differences between C3H/HeJ mice at each age tested (P = 0.2 for age). Although the effect of age has not been thoroughly assessed in other strains, no obvious age-related differences have been identified in other strains analyzed at multiple ages except for the glaucomatous DBA/2J and AKXD-28/Ty strains [14,19]. Effect of sex on IOP Although we have not rigorously assessed the effect of sex on IOP in many strains, sex specific differences have not been detected in the majority of strains for which both sexes have been analyzed, and have proven inconsistent even within an individual strain analyzed multiple times. Strains B6 and 129P3/J have been extensively evaluated at multiple ages between 3 and 24 months of age. Sex differences were always absent in strain 129P3/J and typically absent in strain B6. In strain B6, however, males infrequently had significantly higher IOP than females. For example, in one experiment, B6 males had an average IOP of 14.2 ± 0.3 mmHg (n = 12) whereas the average IOP of females was 13.1 ± 0.3 mmHg (n = 12, P = 0.01). If real, this sporadic sex difference was not dependent on age, sometimes occurring in a group of B6 mice at a particular age and sometimes not occurring in a separate group of the same age. Anesthesia protocol avoids IOP alteration and allows detection of diurnal differences All IOPs were assessed using an anesthetic regime of 99 mg/kg ketamine and 9 mg/kg xylazine (defined as 1X). Initial experiments suggested that an almost identical dose (100 mg/kg ketamine and 9 mg/kg xylazine) of anesthesia had no effect on IOP during the experimental period with IOP being measured as soon as possible after the mouse was unconscious, typically minutes. [13]. To further assess the effects of anesthesia, we measured IOP in groups of genetically identical B6 mice subjected to different doses (1X, 1.5X and 2X) at 5 and 25 minutes after administration (Figure 5). For all doses, IOP decreased by 25 minutes (P = 0.005 for time). The greater the dose the greater the decrease in IOP. At the 5 minute measurement, however, IOP was the same using all doses suggesting that the anesthetic effect on IOP had not yet occurred. To identify any early window when it may be possible to assess IOP without an obvious anesthetic effect, 195 mice of strain B6 were anesthetized with the 1X dose and IOP was measured at 1 minute time points between 4 and 12 minutes after administration (Figure 5). The mean IOP of groups analyzed at each time point did not differ (P = 0.9) indicating that the IOP depressing effect of anesthesia occurs later than 12 minutes after administration. Similar results were obtained using 161 strain 129P3/J and 145 strain DBA/2J mice with the 1X dose (129P3/J, P = 0.1; DBA/2J, P = 0.2). In support of a later effect of anesthesia (since general anesthesia is reported to mask diurnal variation in IOP [21]), we identified increased IOP during the dark compared to the light period of the day in several tested strains (Figure 6). In these experiments, IOP measurements were made between 5 and 12 minutes after administration of anesthesia. Figure 5 No effect of 1X anesthetic dose within 12 minutes of administration. A Mean IOP ± SD is shown for C57BL/6J mice at 5 and 25 minutes after administration of various doses of anesthetic. The 1X dose consisted of 99 mg/kg ketamine and 9 mg/kg xylazine. All doses decreased IOP by 25 minutes. At all doses the IOP at 5 minutes was the same suggesting that the effect of anesthesia had not yet occurred. Approximately thirty 3 to 4 month old mice were analyzed at each dose and time B-D. Scatter-plots demonstrating no change in IOP over the 12 minutes following anesthetic administration in three relatively unrelated mouse strains. All strains consisted of males and females that ranged from 3 to 6 months of age. The sexes and ages were equally represented at each time point. The scatter-plots include 195 C57BL/6J, 161 129P3/J and 145 DBA/2J mice. Figure 6 IOP is increased during the dark compared to light periods in several strains. Mean IOP ± SEM is shown for the indicated strains
T8283	8549-8551	IN	denotes	at
T8032	8549-8551	IN	denotes	at
T8284	8552-8561	JJ	denotes	different
T8033	8552-8561	JJ	denotes	different
T8034	8562-8567	NNS	denotes	times
T8035	8568-8570	IN	denotes	of
T8036	8571-8582	NN	denotes	measurement
T8037	8582-8583	.	denotes	.
T8038	8583-8658	sentence	denotes	The measurement times within a single year were separated by a few months.
T8039	8584-8587	DT	denotes	The
T8041	8588-8599	NN	denotes	measurement
T8040	8600-8605	NNS	denotes	times
T8043	8606-8612	IN	denotes	within
T8044	8613-8614	DT	denotes	a
T8046	8615-8621	JJ	denotes	single
T8045	8622-8626	NN	denotes	year
T8047	8627-8631	VBD	denotes	were
T8042	8632-8641	VBN	denotes	separated
T8048	8642-8644	IN	denotes	by
T8049	8645-8646	DT	denotes	a
T8051	8647-8650	JJ	denotes	few
T8050	8651-8657	NNS	denotes	months
T8052	8657-8658	.	denotes	.
T8053	8658-8830	sentence	denotes	The IOPs of strains that were analyzed multiple times in the same year are listed in the chronological order that they were obtained with the earliest measurement on left.
T8054	8659-8662	DT	denotes	The
T8055	8663-8667	NNS	denotes	IOPs
T8057	8668-8670	IN	denotes	of
T8058	8671-8678	NNS	denotes	strains
T8059	8679-8683	WDT	denotes	that
T8061	8684-8688	VBD	denotes	were
T8060	8689-8697	VBN	denotes	analyzed
T8062	8698-8706	JJ	denotes	multiple
T8063	8707-8712	NNS	denotes	times
T8064	8713-8715	IN	denotes	in
T8065	8716-8719	DT	denotes	the
T8067	8720-8724	JJ	denotes	same
T8066	8725-8729	NN	denotes	year
T8068	8730-8733	VBP	denotes	are
T8056	8734-8740	VBN	denotes	listed
T8069	8741-8743	IN	denotes	in
T8070	8744-8747	DT	denotes	the
T8072	8748-8761	JJ	denotes	chronological
T8071	8762-8767	NN	denotes	order
T8074	8768-8772	IN	denotes	that
T8076	8773-8777	PRP	denotes	they
T8077	8778-8782	VBD	denotes	were
T8075	8783-8791	VBN	denotes	obtained
T8078	8792-8796	IN	denotes	with
T8073	8797-8800	DT	denotes	the
T8082	8801-8809	JJS	denotes	earliest
T8080	8810-8821	NN	denotes	measurement
T8079	8822-8824	IN	denotes	on
T8083	8825-8829	NN	denotes	left
T8084	8829-8830	.	denotes	.
T8085	8830-9100	sentence	denotes	The sex [Male (M) or Female (F)], age (months), and number of mice (n) analyzed for the CBA strains are listed starting with the earliest measurement and ending with the latest: CBA/CaJ, F, n = 22, age 6–7; M, n = 11, age 2; CBA/CaHN, F, n = 16, age 3; M, n = 8, age 3.
T8086	8831-8834	DT	denotes	The
T8087	8835-8838	NN	denotes	sex
T8089	8839-8840	-LRB-	denotes	[
T8090	8840-8844	NN	denotes	Male
T8091	8845-8846	-LRB-	denotes	(
T8092	8846-8847	NN	denotes	M
T8093	8847-8848	-RRB-	denotes	)
T8094	8849-8851	CC	denotes	or
T8095	8852-8858	JJ	denotes	Female
T8096	8859-8860	-LRB-	denotes	(
T8097	8860-8861	NN	denotes	F
T8098	8861-8862	-RRB-	denotes	)
T8099	8862-8863	-RRB-	denotes	]
T8100	8863-8865	,	denotes	,
T8101	8865-8868	NN	denotes	age
T8102	8869-8870	-LRB-	denotes	(
T8103	8870-8876	NNS	denotes	months
T8104	8876-8877	-RRB-	denotes	)
T8105	8877-8879	,	denotes	,
T8106	8879-8882	CC	denotes	and
T8107	8883-8889	NN	denotes	number
T8108	8890-8892	IN	denotes	of
T8109	8893-8897	NNS	denotes	mice
T8081	8898-8899	-LRB-	denotes	(
T8110	8899-8900	NN	denotes	n
T8111	8900-8901	-RRB-	denotes	)
T8112	8902-8910	VBN	denotes	analyzed
T8113	8911-8914	IN	denotes	for
T8114	8915-8918	DT	denotes	the
T8116	8919-8922	NN	denotes	CBA
T8115	8923-8930	NNS	denotes	strains
T8117	8931-8934	VBP	denotes	are
T8088	8935-8941	VBN	denotes	listed
T8118	8942-8950	VBG	denotes	starting
T8119	8951-8955	IN	denotes	with
T8120	8956-8959	DT	denotes	the
T8122	8960-8968	JJS	denotes	earliest
T8121	8969-8980	NN	denotes	measurement
T8123	8981-8984	CC	denotes	and
T8124	8985-8991	VBG	denotes	ending
T8125	8992-8996	IN	denotes	with
T8126	8997-9000	DT	denotes	the
T8127	9001-9007	JJS	denotes	latest
T8128	9007-9009	:	denotes	:
T8129	9009-9012	NN	denotes	CBA
T8131	9012-9013	HYPH	denotes	/
T8130	9013-9016	NN	denotes	CaJ
T8133	9016-9018	,	denotes	,
T8134	9018-9019	NN	denotes	F
T8136	9019-9021	,	denotes	,
T8137	9021-9022	NN	denotes	n
T8138	9023-9024	SYM	denotes	=
T8135	9025-9027	CD	denotes	22
T8139	9027-9029	,	denotes	,
T8140	9029-9032	NN	denotes	age
T8141	9033-9034	CD	denotes	6
T8142	9034-9035	SYM	denotes	–
T8143	9035-9036	CD	denotes	7
T8144	9036-9037	:	denotes	;
T8145	9038-9039	NN	denotes	M
T8147	9039-9041	,	denotes	,
T8148	9041-9042	NN	denotes	n
T8149	9043-9044	SYM	denotes	=
T8146	9045-9047	CD	denotes	11
T8150	9047-9049	,	denotes	,
T8151	9049-9052	NN	denotes	age
T8152	9053-9054	CD	denotes	2
T8153	9054-9055	:	denotes	;
T8154	9056-9059	NN	denotes	CBA
T8155	9059-9060	HYPH	denotes	/
T8132	9060-9064	NN	denotes	CaHN
T8156	9064-9066	,	denotes	,
T8157	9066-9067	NN	denotes	F
T8159	9067-9069	,	denotes	,
T8160	9069-9070	NN	denotes	n
T8161	9071-9072	SYM	denotes	=
T8158	9073-9075	CD	denotes	16
T8162	9075-9077	,	denotes	,
T8163	9077-9080	NN	denotes	age
T8164	9081-9082	CD	denotes	3
T8165	9082-9083	:	denotes	;
T8166	9084-9085	NN	denotes	M
T8168	9085-9087	,	denotes	,
T8169	9087-9088	NN	denotes	n
T8170	9089-9090	SYM	denotes	=
T8167	9091-9092	CD	denotes	8
T8171	9092-9094	,	denotes	,
T8172	9094-9097	NN	denotes	age
T8173	9098-9099	CD	denotes	3
T8174	9099-9100	.	denotes	.
T8175	9100-9180	sentence	denotes	For BALB/cJ and C57BL/6J, all groups were male and primarily 3 to 4 months old.
T8176	9101-9104	IN	denotes	For
T8178	9105-9109	NN	denotes	BALB
T8180	9109-9110	HYPH	denotes	/
T8179	9110-9112	NN	denotes	cJ
T8181	9113-9116	CC	denotes	and
T8182	9117-9122	NN	denotes	C57BL
T8185	9122-9123	HYPH	denotes	/
T8184	9123-9125	NN	denotes	6J
T8186	9125-9127	,	denotes	,
T8187	9127-9130	DT	denotes	all
T8188	9131-9137	NNS	denotes	groups
T8177	9138-9142	VBD	denotes	were
T8189	9143-9147	JJ	denotes	male
T8190	9148-9151	CC	denotes	and
T8191	9152-9161	RB	denotes	primarily
T8192	9162-9163	CD	denotes	3
T8194	9164-9166	IN	denotes	to
T8193	9167-9168	CD	denotes	4
T8195	9169-9175	NNS	denotes	months
T8183	9176-9179	JJ	denotes	old
T8196	9179-9180	.	denotes	.
T8197	9180-9298	sentence	denotes	The number of mice analyzed at each time follows: BALB/cJ 8, 10, 11, 15, 18 and 14, C57BL/6J 10, 14, 21,40,40 and 42.
T8198	9181-9184	DT	denotes	The
T8199	9185-9191	NN	denotes	number
T8201	9192-9194	IN	denotes	of
T8202	9195-9199	NNS	denotes	mice
T8203	9200-9208	VBN	denotes	analyzed
T8204	9209-9211	IN	denotes	at
T8205	9212-9216	DT	denotes	each
T8206	9217-9221	NN	denotes	time
T8200	9222-9229	VBZ	denotes	follows
T8207	9229-9231	:	denotes	:
T8208	9231-9235	NN	denotes	BALB
T8210	9235-9236	HYPH	denotes	/
T8209	9236-9238	NN	denotes	cJ
T8211	9239-9240	CD	denotes	8
T8213	9240-9242	,	denotes	,
T8214	9242-9244	CD	denotes	10
T8215	9244-9246	,	denotes	,
T8216	9246-9248	CD	denotes	11
T8217	9248-9250	,	denotes	,
T8218	9250-9252	CD	denotes	15
T8219	9252-9254	,	denotes	,
T8220	9254-9256	CD	denotes	18
T8221	9257-9260	CC	denotes	and
T8222	9261-9263	CD	denotes	14
T8223	9263-9265	,	denotes	,
T8224	9265-9270	NN	denotes	C57BL
T8226	9270-9271	HYPH	denotes	/
T8225	9271-9273	NN	denotes	6J
T8212	9274-9276	CD	denotes	10
T8227	9276-9278	,	denotes	,
T8228	9278-9280	CD	denotes	14
T8229	9280-9282	,	denotes	,
T8230	9282-9284	CD	denotes	21
T8231	9284-9285	,	denotes	,
T8232	9285-9287	CD	denotes	40
T8233	9287-9288	,	denotes	,
T8234	9288-9290	CD	denotes	40
T8235	9291-9294	CC	denotes	and
T8236	9295-9297	CD	denotes	42
T8237	9297-9298	.	denotes	.
T8238	9298-9356	sentence	denotes	Strain name CBA/CaHN-Btkxid/J is abbreviated to CBA/CaHN.
T8239	9299-9305	NN	denotes	Strain
T8241	9306-9310	NN	denotes	name
T8242	9311-9314	NN	denotes	CBA
T8244	9314-9315	HYPH	denotes	/
T8243	9315-9319	NN	denotes	CaHN
T8245	9319-9320	HYPH	denotes	-
T8246	9320-9326	NN	denotes	Btkxid
T8247	9326-9327	HYPH	denotes	/
T8240	9327-9328	NN	denotes	J
T8249	9329-9331	VBZ	denotes	is
T8248	9332-9343	VBN	denotes	abbreviated
T8250	9344-9346	IN	denotes	to
T8251	9347-9350	NN	denotes	CBA
T8253	9350-9351	HYPH	denotes	/
T8252	9351-9355	NN	denotes	CaHN
T8254	9355-9356	.	denotes	.
T1310	9357-9364	IN	denotes	Despite
T1312	9365-9368	DT	denotes	the
T1314	9369-9376	JJ	denotes	general
T1313	9377-9388	NN	denotes	consistency
T1315	9389-9391	IN	denotes	of
T1316	9392-9395	NN	denotes	IOP
T1317	9395-9397	,	denotes	,
T1318	9397-9400	DT	denotes	the
T1320	9401-9408	JJ	denotes	average
T1319	9409-9413	NNS	denotes	IOPs
T1321	9414-9416	IN	denotes	of
T1322	9417-9421	DT	denotes	some
T1323	9422-9429	NNS	denotes	strains
T1324	9430-9434	VBP	denotes	have
T1311	9435-9442	VBN	denotes	changed
T1325	9443-9445	IN	denotes	in
T1326	9446-9447	DT	denotes	a
T1328	9448-9460	JJ	denotes	reproducible
T1327	9461-9467	NN	denotes	manner
T1329	9467-9468	.	denotes	.
T1330	9468-9577	sentence	denotes	The IOPs of BALB/cJ mice (low end of spectrum) were very similar for the past several years, around 11 mmHg.
T1331	9469-9472	DT	denotes	The
T1332	9473-9477	NNS	denotes	IOPs
T1334	9478-9480	IN	denotes	of
T1335	9481-9485	NN	denotes	BALB
T1337	9485-9486	HYPH	denotes	/
T1336	9486-9488	NN	denotes	cJ
T1338	9489-9493	NNS	denotes	mice
T1339	9494-9495	-LRB-	denotes	(
T1341	9495-9498	JJ	denotes	low
T1340	9499-9502	NN	denotes	end
T1342	9503-9505	IN	denotes	of
T1343	9506-9514	NN	denotes	spectrum
T1344	9514-9515	-RRB-	denotes	)
T1333	9516-9520	VBD	denotes	were
T1345	9521-9525	RB	denotes	very
T1346	9526-9533	JJ	denotes	similar
T1347	9534-9537	IN	denotes	for
T1348	9538-9541	DT	denotes	the
T1350	9542-9546	JJ	denotes	past
T1349	9547-9554	JJ	denotes	several
T1351	9555-9560	NNS	denotes	years
T1352	9560-9562	,	denotes	,
T1353	9562-9568	IN	denotes	around
T1354	9569-9571	CD	denotes	11
T1355	9572-9576	NN	denotes	mmHg
T1356	9576-9577	.	denotes	.
T1357	9577-9712	sentence	denotes	Between early 1996 and 1997, however, the IOP of this strain did jump from approximately 7.7 mmHg to approximately 11 mmHg (Figure 3).
T1358	9578-9585	IN	denotes	Between
T1360	9586-9591	RB	denotes	early
T1361	9592-9596	CD	denotes	1996
T1362	9597-9600	CC	denotes	and
T1363	9601-9605	CD	denotes	1997
T1364	9605-9607	,	denotes	,
T1365	9607-9614	RB	denotes	however
T1366	9614-9616	,	denotes	,
T1367	9616-9619	DT	denotes	the
T1368	9620-9623	NN	denotes	IOP
T1369	9624-9626	IN	denotes	of
T1370	9627-9631	DT	denotes	this
T1371	9632-9638	NN	denotes	strain
T1372	9639-9642	VBD	denotes	did
T1359	9643-9647	VB	denotes	jump
T1373	9648-9652	IN	denotes	from
T1374	9653-9666	RB	denotes	approximately
T1375	9667-9670	CD	denotes	7.7
T1376	9671-9675	NN	denotes	mmHg
T1377	9676-9678	IN	denotes	to
T1378	9679-9692	RB	denotes	approximately
T1379	9693-9695	CD	denotes	11
T1380	9696-9700	NN	denotes	mmHg
T1381	9701-9702	-LRB-	denotes	(
T1382	9702-9708	NN	denotes	Figure
T1383	9709-9710	CD	denotes	3
T1384	9710-9711	-RRB-	denotes	)
T1385	9711-9712	.	denotes	.
T1386	9712-9827	sentence	denotes	During this period, the room in which our animals were housed and the manufacturer of the mouse diet were changed.
T1387	9713-9719	IN	denotes	During
T1389	9720-9724	DT	denotes	this
T1390	9725-9731	NN	denotes	period
T1391	9731-9733	,	denotes	,
T1392	9733-9736	DT	denotes	the
T1393	9737-9741	NN	denotes	room
T1394	9742-9744	IN	denotes	in
T1396	9745-9750	WDT	denotes	which
T1397	9751-9754	PRP$	denotes	our
T1398	9755-9762	NNS	denotes	animals
T1399	9763-9767	VBD	denotes	were
T1395	9768-9774	VBN	denotes	housed
T1400	9775-9778	CC	denotes	and
T1401	9779-9782	DT	denotes	the
T1402	9783-9795	NN	denotes	manufacturer
T1403	9796-9798	IN	denotes	of
T1404	9799-9802	DT	denotes	the
T1406	9803-9808	NN	denotes	mouse
T1405	9809-9813	NN	denotes	diet
T1407	9814-9818	VBD	denotes	were
T1388	9819-9826	VBN	denotes	changed
T1408	9826-9827	.	denotes	.
T1409	9827-9967	sentence	denotes	Over the same period, the IOP of A/J also increased dramatically, from 9.4 ± 0.5 mmHg (n = 11) in 1996 to 14.2 ± 0.4 mmHg (n = 19) in 1997.
T1410	9828-9832	IN	denotes	Over
T1412	9833-9836	DT	denotes	the
T1414	9837-9841	JJ	denotes	same
T1413	9842-9848	NN	denotes	period
T1415	9848-9850	,	denotes	,
T1416	9850-9853	DT	denotes	the
T1417	9854-9857	NN	denotes	IOP
T1418	9858-9860	IN	denotes	of
T1419	9861-9862	NN	denotes	A
T1421	9862-9863	HYPH	denotes	/
T1420	9863-9864	NN	denotes	J
T1422	9865-9869	RB	denotes	also
T1411	9870-9879	VBD	denotes	increased
T1423	9880-9892	RB	denotes	dramatically
T1424	9892-9894	,	denotes	,
T1425	9894-9898	IN	denotes	from
T1426	9899-9902	CD	denotes	9.4
T1428	9903-9904	HYPH	denotes	±
T1427	9905-9908	CD	denotes	0.5
T1429	9909-9913	NN	denotes	mmHg
T1430	9914-9915	-LRB-	denotes	(
T1432	9915-9916	NN	denotes	n
T1433	9917-9918	SYM	denotes	=
T1431	9919-9921	CD	denotes	11
T1434	9921-9922	-RRB-	denotes	)
T1435	9923-9925	IN	denotes	in
T1436	9926-9930	CD	denotes	1996
T1437	9931-9933	IN	denotes	to
T1438	9934-9938	CD	denotes	14.2
T1440	9939-9940	HYPH	denotes	±
T1439	9941-9944	CD	denotes	0.4
T1441	9945-9949	NN	denotes	mmHg
T1442	9950-9951	-LRB-	denotes	(
T1444	9951-9952	NN	denotes	n
T1445	9953-9954	SYM	denotes	=
T1443	9955-9957	CD	denotes	19
T1446	9957-9958	-RRB-	denotes	)
T1447	9959-9961	IN	denotes	in
T1448	9962-9966	CD	denotes	1997
T1449	9966-9967	.	denotes	.
T1450	9967-10102	sentence	denotes	The increased IOP in A/J also was reproducible, with the average IOP of mice assessed in the year 2000 being 14.5 ± 0.4 mmHg (n = 16).
T1451	9968-9971	DT	denotes	The
T1453	9972-9981	VBN	denotes	increased
T1452	9982-9985	NN	denotes	IOP
T1455	9986-9988	IN	denotes	in
T1456	9989-9990	NN	denotes	A
T1458	9990-9991	HYPH	denotes	/
T1457	9991-9992	NN	denotes	J
T1459	9993-9997	RB	denotes	also
T1454	9998-10001	VBD	denotes	was
T1460	10002-10014	JJ	denotes	reproducible
T1461	10014-10016	,	denotes	,
T1462	10016-10020	IN	denotes	with
T1463	10021-10024	DT	denotes	the
T1465	10025-10032	JJ	denotes	average
T1464	10033-10036	NN	denotes	IOP
T1467	10037-10039	IN	denotes	of
T1468	10040-10044	NNS	denotes	mice
T1469	10045-10053	VBN	denotes	assessed
T1470	10054-10056	IN	denotes	in
T1471	10057-10060	DT	denotes	the
T1472	10061-10065	NN	denotes	year
T1473	10066-10070	CD	denotes	2000
T1466	10071-10076	VBG	denotes	being
T1474	10077-10081	CD	denotes	14.5
T1476	10082-10083	SYM	denotes	±
T1475	10084-10087	CD	denotes	0.4
T1477	10088-10092	NN	denotes	mmHg
T1478	10093-10094	-LRB-	denotes	(
T1480	10094-10095	NN	denotes	n
T1481	10096-10097	SYM	denotes	=
T1479	10098-10100	CD	denotes	16
T1482	10100-10101	-RRB-	denotes	)
T1483	10101-10102	.	denotes	.
T1484	10102-10332	sentence	denotes	Importantly, the IOPs of strains B6 and C3H/HeJ did not change during this time (B6, 12.3. ± 0.5 mmHg in 1996 and 12.4 ± 0.3 mmHg in 1997, n= 10 and 14; C3H/HeJ, 13.7 ± 0.8 mmHg in 1996 and 13.6 ± 0.2 mmHg in 1997, n = 9 and 19).
T1485	10103-10114	RB	denotes	Importantly
T1487	10114-10116	,	denotes	,
T1488	10116-10119	DT	denotes	the
T1489	10120-10124	NNS	denotes	IOPs
T1490	10125-10127	IN	denotes	of
T1491	10128-10135	NNS	denotes	strains
T1492	10136-10138	NN	denotes	B6
T1493	10139-10142	CC	denotes	and
T1494	10143-10146	NN	denotes	C3H
T1496	10146-10147	HYPH	denotes	/
T1495	10147-10150	NN	denotes	HeJ
T1497	10151-10154	VBD	denotes	did
T1498	10155-10158	RB	denotes	not
T1486	10159-10165	VB	denotes	change
T1499	10166-10172	IN	denotes	during
T1500	10173-10177	DT	denotes	this
T1501	10178-10182	NN	denotes	time
T1502	10183-10184	-LRB-	denotes	(
T1504	10184-10186	NN	denotes	B6
T1506	10186-10188	,	denotes	,
T1507	10188-10193	CD	denotes	12.3.
T1509	10194-10195	SYM	denotes	±
T1508	10196-10199	CD	denotes	0.5
T1510	10200-10204	NN	denotes	mmHg
T1511	10205-10207	IN	denotes	in
T1512	10208-10212	CD	denotes	1996
T1513	10213-10216	CC	denotes	and
T1514	10217-10221	CD	denotes	12.4
T1516	10222-10223	SYM	denotes	±
T1515	10224-10227	CD	denotes	0.3
T1517	10228-10232	NN	denotes	mmHg
T1518	10233-10235	IN	denotes	in
T1519	10236-10240	CD	denotes	1997
T1520	10240-10242	,	denotes	,
T1521	10242-10243	NN	denotes	n
T1522	10243-10244	SYM	denotes	=
T1505	10245-10247	CD	denotes	10
T1523	10248-10251	CC	denotes	and
T1524	10252-10254	CD	denotes	14
T1525	10254-10255	:	denotes	;
T1526	10256-10259	NN	denotes	C3H
T1528	10259-10260	HYPH	denotes	/
T1527	10260-10263	NN	denotes	HeJ
T1529	10263-10265	,	denotes	,
T1530	10265-10269	CD	denotes	13.7
T1532	10270-10271	SYM	denotes	±
T1531	10272-10275	CD	denotes	0.8
T1533	10276-10280	NN	denotes	mmHg
T1534	10281-10283	IN	denotes	in
T1535	10284-10288	CD	denotes	1996
T1536	10289-10292	CC	denotes	and
T1537	10293-10297	CD	denotes	13.6
T1539	10298-10299	SYM	denotes	±
T1538	10300-10303	CD	denotes	0.2
T1540	10304-10308	NN	denotes	mmHg
T1541	10309-10311	IN	denotes	in
T1542	10312-10316	CD	denotes	1997
T1543	10316-10318	,	denotes	,
T1544	10318-10319	NN	denotes	n
T1545	10320-10321	SYM	denotes	=
T1503	10322-10323	CD	denotes	9
T1546	10324-10327	CC	denotes	and
T1547	10328-10330	CD	denotes	19
T1548	10330-10331	-RRB-	denotes	)
T1549	10331-10332	.	denotes	.
T1568	10334-10340	NN	denotes	Effect
T1569	10341-10343	IN	denotes	of
T1570	10344-10347	NN	denotes	age
T1571	10348-10350	IN	denotes	on
T1572	10351-10354	NN	denotes	IOP
T1573	10354-10469	sentence	denotes	We focused on the commonly used B6, 129P3/J and C3H/HeJ strains to determine the effects of age on IOP (Figure 4).
T1574	10355-10357	PRP	denotes	We
T1575	10358-10365	VBD	denotes	focused
T1576	10366-10368	IN	denotes	on
T1577	10369-10372	DT	denotes	the
T1579	10373-10381	RB	denotes	commonly
T1580	10382-10386	VBN	denotes	used
T1581	10387-10389	NN	denotes	B6
T1582	10389-10391	,	denotes	,
T1583	10391-10396	NN	denotes	129P3
T1585	10396-10397	HYPH	denotes	/
T1584	10397-10398	NN	denotes	J
T1586	10399-10402	CC	denotes	and
T1587	10403-10406	NN	denotes	C3H
T1589	10406-10407	HYPH	denotes	/
T1588	10407-10410	NN	denotes	HeJ
T1578	10411-10418	NNS	denotes	strains
T1590	10419-10421	TO	denotes	to
T1591	10422-10431	VB	denotes	determine
T1592	10432-10435	DT	denotes	the
T1593	10436-10443	NNS	denotes	effects
T1594	10444-10446	IN	denotes	of
T1595	10447-10450	NN	denotes	age
T1596	10451-10453	IN	denotes	on
T1597	10454-10457	NN	denotes	IOP
T1598	10458-10459	-LRB-	denotes	(
T1599	10459-10465	NN	denotes	Figure
T1600	10466-10467	CD	denotes	4
T1601	10467-10468	-RRB-	denotes	)
T1602	10468-10469	.	denotes	.
T1603	10469-10525	sentence	denotes	In B6, age had a significant effect on IOP (P < 0.001).
T1604	10470-10472	IN	denotes	In
T1606	10473-10475	NN	denotes	B6
T1607	10475-10477	,	denotes	,
T1608	10477-10480	NN	denotes	age
T1605	10481-10484	VBD	denotes	had
T1609	10485-10486	DT	denotes	a
T1611	10487-10498	JJ	denotes	significant
T1610	10499-10505	NN	denotes	effect
T1612	10506-10508	IN	denotes	on
T1613	10509-10512	NN	denotes	IOP
T1614	10513-10514	-LRB-	denotes	(
T1616	10514-10515	NN	denotes	P
T1617	10516-10517	SYM	denotes	<
T1615	10518-10523	CD	denotes	0.001
T1618	10523-10524	-RRB-	denotes	)
T1619	10524-10525	.	denotes	.
T1620	10525-10691	sentence	denotes	IOP was slightly decreased at both 12 months (12.2 ± 0.2 mmHg) and 19 months (12.2 ± 0.3 mmHg) compared to 3 months (13.1 ± 0.3 mmHg) and 7 months (13.3 ± 0.3 mmHg).
T1621	10526-10529	NN	denotes	IOP
T1622	10530-10533	VBD	denotes	was
T1623	10534-10542	RB	denotes	slightly
T1624	10543-10552	JJ	denotes	decreased
T1625	10553-10555	IN	denotes	at
T1626	10556-10560	CC	denotes	both
T1628	10561-10563	CD	denotes	12
T1627	10564-10570	NNS	denotes	months
T1629	10571-10572	-LRB-	denotes	(
T1631	10572-10576	CD	denotes	12.2
T1633	10577-10578	SYM	denotes	±
T1632	10579-10582	CD	denotes	0.2
T1630	10583-10587	NN	denotes	mmHg
T1634	10587-10588	-RRB-	denotes	)
T1635	10589-10592	CC	denotes	and
T1636	10593-10595	CD	denotes	19
T1637	10596-10602	NNS	denotes	months
T1638	10603-10604	-LRB-	denotes	(
T1640	10604-10608	CD	denotes	12.2
T1642	10609-10610	SYM	denotes	±
T1641	10611-10614	CD	denotes	0.3
T1639	10615-10619	NN	denotes	mmHg
T1643	10619-10620	-RRB-	denotes	)
T1644	10621-10629	VBN	denotes	compared
T1645	10630-10632	IN	denotes	to
T1646	10633-10634	CD	denotes	3
T1647	10635-10641	NNS	denotes	months
T1648	10642-10643	-LRB-	denotes	(
T1650	10643-10647	CD	denotes	13.1
T1652	10648-10649	SYM	denotes	±
T1651	10650-10653	CD	denotes	0.3
T1649	10654-10658	NN	denotes	mmHg
T1653	10658-10659	-RRB-	denotes	)
T1654	10660-10663	CC	denotes	and
T1655	10664-10665	CD	denotes	7
T1656	10666-10672	NNS	denotes	months
T1657	10673-10674	-LRB-	denotes	(
T1659	10674-10678	CD	denotes	13.3
T1661	10679-10680	SYM	denotes	±
T1660	10681-10684	CD	denotes	0.3
T1658	10685-10689	NN	denotes	mmHg
T1662	10689-10690	-RRB-	denotes	)
T1663	10690-10691	.	denotes	.
T1664	10691-10917	sentence	denotes	Although the decrease was of a similar level to the variation observed in 3 month old mice (see Figure 3), the IOPs of control young mice (see Methods) analyzed at the same times as the various B6 age groups did not decrease.
T1665	10692-10700	IN	denotes	Although
T1667	10701-10704	DT	denotes	the
T1668	10705-10713	NN	denotes	decrease
T1666	10714-10717	VBD	denotes	was
T1670	10718-10720	IN	denotes	of
T1671	10721-10722	DT	denotes	a
T1673	10723-10730	JJ	denotes	similar
T1672	10731-10736	NN	denotes	level
T1674	10737-10739	IN	denotes	to
T1675	10740-10743	DT	denotes	the
T1676	10744-10753	NN	denotes	variation
T1677	10754-10762	VBN	denotes	observed
T1678	10763-10765	IN	denotes	in
T1679	10766-10767	CD	denotes	3
T1681	10768-10773	NN	denotes	month
T1680	10774-10777	JJ	denotes	old
T1682	10778-10782	NNS	denotes	mice
T1683	10783-10784	-LRB-	denotes	(
T1684	10784-10787	VB	denotes	see
T1685	10788-10794	NN	denotes	Figure
T1686	10795-10796	CD	denotes	3
T1687	10796-10797	-RRB-	denotes	)
T1688	10797-10799	,	denotes	,
T1689	10799-10802	DT	denotes	the
T1690	10803-10807	NNS	denotes	IOPs
T1691	10808-10810	IN	denotes	of
T1692	10811-10818	NN	denotes	control
T1694	10819-10824	JJ	denotes	young
T1693	10825-10829	NNS	denotes	mice
T1695	10830-10831	-LRB-	denotes	(
T1696	10831-10834	VB	denotes	see
T1697	10835-10842	NNS	denotes	Methods
T1698	10842-10843	-RRB-	denotes	)
T1699	10844-10852	VBN	denotes	analyzed
T1700	10853-10855	IN	denotes	at
T1701	10856-10859	DT	denotes	the
T1703	10860-10864	JJ	denotes	same
T1702	10865-10870	NNS	denotes	times
T1704	10871-10873	IN	denotes	as
T1705	10874-10877	DT	denotes	the
T1707	10878-10885	JJ	denotes	various
T1708	10886-10888	NN	denotes	B6
T1709	10889-10892	NN	denotes	age
T1706	10893-10899	NNS	denotes	groups
T1710	10900-10903	VBD	denotes	did
T1711	10904-10907	RB	denotes	not
T1669	10908-10916	VB	denotes	decrease
T1712	10916-10917	.	denotes	.
T1713	10917-11125	sentence	denotes	For example, control mice analyzed at the same time as the 3 month, 12 month and 18 month B6 age groups had IOPs of 13.0 ± 0.2 mmHg (n = 14), 13.3 ± 0.2 mmHg (n = 14), 13.7 ± 0.4 mmHg (n = 12), respectively.
T1714	10918-10921	IN	denotes	For
T1716	10922-10929	NN	denotes	example
T1717	10929-10931	,	denotes	,
T1718	10931-10938	NN	denotes	control
T1719	10939-10943	NNS	denotes	mice
T1720	10944-10952	VBN	denotes	analyzed
T1721	10953-10955	IN	denotes	at
T1722	10956-10959	DT	denotes	the
T1724	10960-10964	JJ	denotes	same
T1723	10965-10969	NN	denotes	time
T1725	10970-10972	IN	denotes	as
T1726	10973-10976	DT	denotes	the
T1728	10977-10978	CD	denotes	3
T1729	10979-10984	NN	denotes	month
T1730	10984-10986	,	denotes	,
T1731	10986-10988	CD	denotes	12
T1732	10989-10994	NN	denotes	month
T1733	10995-10998	CC	denotes	and
T1734	10999-11001	CD	denotes	18
T1735	11002-11007	NN	denotes	month
T1736	11008-11010	NN	denotes	B6
T1737	11011-11014	NN	denotes	age
T1727	11015-11021	NNS	denotes	groups
T1715	11022-11025	VBD	denotes	had
T1738	11026-11030	NNS	denotes	IOPs
T1739	11031-11033	IN	denotes	of
T1740	11034-11038	CD	denotes	13.0
T1742	11039-11040	SYM	denotes	±
T1741	11041-11044	CD	denotes	0.2
T1743	11045-11049	NN	denotes	mmHg
T1744	11050-11051	-LRB-	denotes	(
T1746	11051-11052	NN	denotes	n
T1747	11053-11054	SYM	denotes	=
T1745	11055-11057	CD	denotes	14
T1748	11057-11058	-RRB-	denotes	)
T1749	11058-11060	,	denotes	,
T1750	11060-11064	CD	denotes	13.3
T1752	11065-11066	SYM	denotes	±
T1751	11067-11070	CD	denotes	0.2
T1753	11071-11075	NN	denotes	mmHg
T1754	11076-11077	-LRB-	denotes	(
T1756	11077-11078	NN	denotes	n
T1757	11079-11080	SYM	denotes	=
T1755	11081-11083	CD	denotes	14
T1758	11083-11084	-RRB-	denotes	)
T1759	11084-11086	,	denotes	,
T1760	11086-11090	CD	denotes	13.7
T1762	11091-11092	SYM	denotes	±
T1761	11093-11096	CD	denotes	0.4
T1763	11097-11101	NN	denotes	mmHg
T1764	11102-11103	-LRB-	denotes	(
T1766	11103-11104	NN	denotes	n
T1767	11105-11106	SYM	denotes	=
T1765	11107-11109	CD	denotes	12
T1768	11109-11110	-RRB-	denotes	)
T1769	11110-11112	,	denotes	,
T1770	11112-11124	RB	denotes	respectively
T1771	11124-11125	.	denotes	.
T1772	11125-11295	sentence	denotes	IOP was even lower in the 24 month B6 mice (10.8 ± 0.4 mmHg), and again the average IOP of young controls measured at the same time was not changed (13.5 ± 0.2, n = 12).
T1773	11126-11129	NN	denotes	IOP
T1774	11130-11133	VBD	denotes	was
T1775	11134-11138	RB	denotes	even
T1776	11139-11144	JJR	denotes	lower
T1777	11145-11147	IN	denotes	in
T1778	11148-11151	DT	denotes	the
T1780	11152-11154	CD	denotes	24
T1781	11155-11160	NN	denotes	month
T1782	11161-11163	NN	denotes	B6
T1779	11164-11168	NNS	denotes	mice
T1783	11169-11170	-LRB-	denotes	(
T1785	11170-11174	CD	denotes	10.8
T1787	11175-11176	SYM	denotes	±
T1786	11177-11180	CD	denotes	0.4
T1784	11181-11185	NN	denotes	mmHg
T1788	11185-11186	-RRB-	denotes	)
T1789	11186-11188	,	denotes	,
T1790	11188-11191	CC	denotes	and
T1791	11192-11197	RB	denotes	again
T1793	11198-11201	DT	denotes	the
T1795	11202-11209	JJ	denotes	average
T1794	11210-11213	NN	denotes	IOP
T1796	11214-11216	IN	denotes	of
T1797	11217-11222	JJ	denotes	young
T1798	11223-11231	NNS	denotes	controls
T1799	11232-11240	VBN	denotes	measured
T1800	11241-11243	IN	denotes	at
T1801	11244-11247	DT	denotes	the
T1803	11248-11252	JJ	denotes	same
T1802	11253-11257	NN	denotes	time
T1804	11258-11261	VBD	denotes	was
T1805	11262-11265	RB	denotes	not
T1792	11266-11273	VBN	denotes	changed
T1806	11274-11275	-LRB-	denotes	(
T1808	11275-11279	CD	denotes	13.5
T1809	11280-11281	SYM	denotes	±
T1807	11282-11285	CD	denotes	0.2
T1810	11285-11287	,	denotes	,
T1811	11287-11288	NN	denotes	n
T1813	11289-11290	SYM	denotes	=
T1812	11291-11293	CD	denotes	12
T1814	11293-11294	-RRB-	denotes	)
T1815	11294-11295	.	denotes	.
T1816	11295-12015	sentence	denotes	Figure 4 IOP changes with increasing Age. Mean IOP ± SEM is shown for the indicated strain at different ages. IOP decreased significantly in strains C57BL/6J and 129P3/J but not C3H/HeJ. The C57BL/6J and 129P3/J groups consisted of approximately equal numbers of males and females. The 3 months old C3H/HeJ mice were male while the other ages were composed of males and females. The number of mice analyzed at each age, listed from youngest to oldest, follow: C57BL/6J, 18, 18, 18, 18, 13; 129P3/J, 18, 15, 16, 14, 21; C3H/HeJ, 15, 23 17 and 16. In strain 129P3/J, IOP did not differ significantly with age between 3 and 14 months but was lower in 18 month old mice (P < 0.001 compared to all younger ages, Figure 4).
T8266	11306-11309	NN	denotes	IOP
T8267	11310-11317	NNS	denotes	changes
T8268	11318-11322	IN	denotes	with
T8269	11323-11333	VBG	denotes	increasing
T8270	11334-11337	NN	denotes	Age
T8271	11337-11338	.	denotes	.
T8272	11338-11407	sentence	denotes	Mean IOP ± SEM is shown for the indicated strain at different ages.
T8285	11402-11406	NNS	denotes	ages
T8286	11406-11407	.	denotes	.
T8287	11407-11484	sentence	denotes	IOP decreased significantly in strains C57BL/6J and 129P3/J but not C3H/HeJ.
T8288	11408-11411	NN	denotes	IOP
T8289	11412-11421	VBD	denotes	decreased
T8290	11422-11435	RB	denotes	significantly
T8291	11436-11438	IN	denotes	in
T8292	11439-11446	NNS	denotes	strains
T8294	11447-11452	NN	denotes	C57BL
T8295	11452-11453	HYPH	denotes	/
T8293	11453-11455	NN	denotes	6J
T8296	11456-11459	CC	denotes	and
T8297	11460-11465	NN	denotes	129P3
T8299	11465-11466	HYPH	denotes	/
T8298	11466-11467	NN	denotes	J
T8300	11468-11471	CC	denotes	but
T8301	11472-11475	RB	denotes	not
T8302	11476-11479	NN	denotes	C3H
T8304	11479-11480	HYPH	denotes	/
T8303	11480-11483	NN	denotes	HeJ
T8305	11483-11484	.	denotes	.
T8306	11484-11579	sentence	denotes	The C57BL/6J and 129P3/J groups consisted of approximately equal numbers of males and females.
T8307	11485-11488	DT	denotes	The
T8309	11489-11494	NN	denotes	C57BL
T8311	11494-11495	HYPH	denotes	/
T8310	11495-11497	NN	denotes	6J
T8312	11498-11501	CC	denotes	and
T8313	11502-11507	NN	denotes	129P3
T8315	11507-11508	HYPH	denotes	/
T8314	11508-11509	NN	denotes	J
T8308	11510-11516	NNS	denotes	groups
T8316	11517-11526	VBD	denotes	consisted
T8317	11527-11529	IN	denotes	of
T8318	11530-11543	RB	denotes	approximately
T8319	11544-11549	JJ	denotes	equal
T8320	11550-11557	NNS	denotes	numbers
T8321	11558-11560	IN	denotes	of
T8322	11561-11566	NNS	denotes	males
T8323	11567-11570	CC	denotes	and
T8324	11571-11578	NNS	denotes	females
T8325	11578-11579	.	denotes	.
T8326	11579-11676	sentence	denotes	The 3 months old C3H/HeJ mice were male while the other ages were composed of males and females.
T8327	11580-11583	DT	denotes	The
T8329	11584-11585	CD	denotes	3
T8330	11586-11592	NNS	denotes	months
T8331	11593-11596	JJ	denotes	old
T8332	11597-11600	NN	denotes	C3H
T8334	11600-11601	HYPH	denotes	/
T8333	11601-11604	NN	denotes	HeJ
T8328	11605-11609	NNS	denotes	mice
T8335	11610-11614	VBD	denotes	were
T8336	11615-11619	JJ	denotes	male
T8337	11620-11625	IN	denotes	while
T8339	11626-11629	DT	denotes	the
T8341	11630-11635	JJ	denotes	other
T8340	11636-11640	NNS	denotes	ages
T8342	11641-11645	VBD	denotes	were
T8338	11646-11654	VBN	denotes	composed
T8343	11655-11657	IN	denotes	of
T8344	11658-11663	NNS	denotes	males
T8345	11664-11667	CC	denotes	and
T8346	11668-11675	NNS	denotes	females
T8347	11675-11676	.	denotes	.
T8348	11676-11843	sentence	denotes	The number of mice analyzed at each age, listed from youngest to oldest, follow: C57BL/6J, 18, 18, 18, 18, 13; 129P3/J, 18, 15, 16, 14, 21; C3H/HeJ, 15, 23 17 and 16.
T8349	11677-11680	DT	denotes	The
T8350	11681-11687	NN	denotes	number
T8352	11688-11690	IN	denotes	of
T8353	11691-11695	NNS	denotes	mice
T8354	11696-11704	VBN	denotes	analyzed
T8355	11705-11707	IN	denotes	at
T8356	11708-11712	DT	denotes	each
T8357	11713-11716	NN	denotes	age
T8358	11716-11718	,	denotes	,
T8359	11718-11724	VBN	denotes	listed
T8360	11725-11729	IN	denotes	from
T8361	11730-11738	JJS	denotes	youngest
T8362	11739-11741	IN	denotes	to
T8363	11742-11748	JJS	denotes	oldest
T8364	11748-11750	,	denotes	,
T8351	11750-11756	VB	denotes	follow
T8365	11756-11758	:	denotes	:
T8366	11758-11763	NN	denotes	C57BL
T8368	11763-11764	HYPH	denotes	/
T8367	11764-11766	NN	denotes	6J
T8370	11766-11768	,	denotes	,
T8371	11768-11770	CD	denotes	18
T8372	11770-11772	,	denotes	,
T8373	11772-11774	CD	denotes	18
T8374	11774-11776	,	denotes	,
T8375	11776-11778	CD	denotes	18
T8376	11778-11780	,	denotes	,
T8377	11780-11782	CD	denotes	18
T8378	11782-11784	,	denotes	,
T8369	11784-11786	CD	denotes	13
T8380	11786-11787	:	denotes	;
T8381	11788-11793	NN	denotes	129P3
T8383	11793-11794	HYPH	denotes	/
T8382	11794-11795	NN	denotes	J
T8385	11795-11797	,	denotes	,
T8386	11797-11799	CD	denotes	18
T8387	11799-11801	,	denotes	,
T8388	11801-11803	CD	denotes	15
T8389	11803-11805	,	denotes	,
T8390	11805-11807	CD	denotes	16
T8391	11807-11809	,	denotes	,
T8392	11809-11811	CD	denotes	14
T8393	11811-11813	,	denotes	,
T8384	11813-11815	CD	denotes	21
T8394	11815-11816	:	denotes	;
T8395	11817-11820	NN	denotes	C3H
T8397	11820-11821	HYPH	denotes	/
T8396	11821-11824	NN	denotes	HeJ
T8398	11824-11826	,	denotes	,
T8379	11826-11828	CD	denotes	15
T8399	11828-11830	,	denotes	,
T8400	11830-11832	CD	denotes	23
T8401	11833-11835	CD	denotes	17
T8402	11836-11839	CC	denotes	and
T8403	11840-11842	CD	denotes	16
T8404	11842-11843	.	denotes	.
T1817	11844-11846	IN	denotes	In
T1819	11847-11853	NN	denotes	strain
T1821	11854-11859	NN	denotes	129P3
T1822	11859-11860	HYPH	denotes	/
T1820	11860-11861	NN	denotes	J
T1823	11861-11863	,	denotes	,
T1824	11863-11866	NN	denotes	IOP
T1825	11867-11870	VBD	denotes	did
T1826	11871-11874	RB	denotes	not
T1818	11875-11881	VB	denotes	differ
T1827	11882-11895	RB	denotes	significantly
T1828	11896-11900	IN	denotes	with
T1829	11901-11904	NN	denotes	age
T1830	11905-11912	IN	denotes	between
T1831	11913-11914	CD	denotes	3
T1833	11915-11918	CC	denotes	and
T1834	11919-11921	CD	denotes	14
T1832	11922-11928	NNS	denotes	months
T1835	11929-11932	CC	denotes	but
T1836	11933-11936	VBD	denotes	was
T1837	11937-11942	JJR	denotes	lower
T1838	11943-11945	IN	denotes	in
T1839	11946-11948	CD	denotes	18
T1840	11949-11954	NN	denotes	month
T1841	11955-11958	JJ	denotes	old
T1842	11959-11963	NNS	denotes	mice
T1843	11964-11965	-LRB-	denotes	(
T1845	11965-11966	NN	denotes	P
T1847	11967-11968	SYM	denotes	<
T1846	11969-11974	CD	denotes	0.001
T1848	11975-11983	VBN	denotes	compared
T1849	11984-11986	IN	denotes	to
T1850	11987-11990	DT	denotes	all
T1852	11991-11998	JJR	denotes	younger
T1851	11999-12003	NNS	denotes	ages
T1853	12003-12005	,	denotes	,
T1844	12005-12011	NN	denotes	Figure
T1854	12012-12013	CD	denotes	4
T1855	12013-12014	-RRB-	denotes	)
T1856	12014-12015	.	denotes	.
T1857	12015-12157	sentence	denotes	Despite a 1 mmHg dip in IOP at 8 months, there were no significant IOP differences between C3H/HeJ mice at each age tested (P = 0.2 for age).
T1858	12016-12023	IN	denotes	Despite
T1860	12024-12025	DT	denotes	a
T1862	12026-12027	CD	denotes	1
T1863	12028-12032	NN	denotes	mmHg
T1861	12033-12036	NN	denotes	dip
T1864	12037-12039	IN	denotes	in
T1865	12040-12043	NN	denotes	IOP
T1866	12044-12046	IN	denotes	at
T1867	12047-12048	CD	denotes	8
T1868	12049-12055	NNS	denotes	months
T1869	12055-12057	,	denotes	,
T1870	12057-12062	EX	denotes	there
T1859	12063-12067	VBD	denotes	were
T1871	12068-12070	DT	denotes	no
T1873	12071-12082	JJ	denotes	significant
T1874	12083-12086	NN	denotes	IOP
T1872	12087-12098	NNS	denotes	differences
T1875	12099-12106	IN	denotes	between
T1876	12107-12110	NN	denotes	C3H
T1878	12110-12111	HYPH	denotes	/
T1877	12111-12114	NN	denotes	HeJ
T1879	12115-12119	NNS	denotes	mice
T1880	12120-12122	IN	denotes	at
T1881	12123-12127	DT	denotes	each
T1882	12128-12131	NN	denotes	age
T1883	12132-12138	VBN	denotes	tested
T1884	12139-12140	-LRB-	denotes	(
T1886	12140-12141	NN	denotes	P
T1887	12142-12143	SYM	denotes	=
T1885	12144-12147	CD	denotes	0.2
T1888	12148-12151	IN	denotes	for
T1889	12152-12155	NN	denotes	age
T1890	12155-12156	-RRB-	denotes	)
T1891	12156-12157	.	denotes	.
T1892	12157-12401	sentence	denotes	Although the effect of age has not been thoroughly assessed in other strains, no obvious age-related differences have been identified in other strains analyzed at multiple ages except for the glaucomatous DBA/2J and AKXD-28/Ty strains [14,19].
T1893	12158-12166	IN	denotes	Although
T1895	12167-12170	DT	denotes	the
T1896	12171-12177	NN	denotes	effect
T1897	12178-12180	IN	denotes	of
T1898	12181-12184	NN	denotes	age
T1899	12185-12188	VBZ	denotes	has
T1900	12189-12192	RB	denotes	not
T1901	12193-12197	VBN	denotes	been
T1902	12198-12208	RB	denotes	thoroughly
T1894	12209-12217	VBN	denotes	assessed
T1904	12218-12220	IN	denotes	in
T1905	12221-12226	JJ	denotes	other
T1906	12227-12234	NNS	denotes	strains
T1907	12234-12236	,	denotes	,
T1908	12236-12238	DT	denotes	no
T1910	12239-12246	JJ	denotes	obvious
T1911	12247-12250	NN	denotes	age
T1913	12250-12251	HYPH	denotes	-
T1912	12251-12258	VBN	denotes	related
T1909	12259-12270	NNS	denotes	differences
T1914	12271-12275	VBP	denotes	have
T1915	12276-12280	VBN	denotes	been
T1903	12281-12291	VBN	denotes	identified
T1916	12292-12294	IN	denotes	in
T1917	12295-12300	JJ	denotes	other
T1918	12301-12308	NNS	denotes	strains
T1919	12309-12317	VBN	denotes	analyzed
T1920	12318-12320	IN	denotes	at
T1921	12321-12329	JJ	denotes	multiple
T1922	12330-12334	NNS	denotes	ages
T1923	12335-12341	IN	denotes	except
T1924	12342-12345	IN	denotes	for
T1925	12346-12349	DT	denotes	the
T1927	12350-12362	JJ	denotes	glaucomatous
T1928	12363-12366	NN	denotes	DBA
T1930	12366-12367	HYPH	denotes	/
T1929	12367-12369	NN	denotes	2J
T1931	12370-12373	CC	denotes	and
T1932	12374-12378	JJ	denotes	AKXD
T1934	12378-12379	HYPH	denotes	-
T1933	12379-12384	JJ	denotes	28/Ty
T1926	12385-12392	NNS	denotes	strains
T1935	12393-12394	-LRB-	denotes	[
T1937	12394-12396	CD	denotes	14
T1938	12396-12397	,	denotes	,
T1936	12397-12399	CD	denotes	19
T1939	12399-12400	-RRB-	denotes	]
T1940	12400-12401	.	denotes	.
T2112	12403-12409	NN	denotes	Effect
T2113	12410-12412	IN	denotes	of
T2114	12413-12416	NN	denotes	sex
T2115	12417-12419	IN	denotes	on
T2116	12420-12423	NN	denotes	IOP
T2117	12423-12709	sentence	denotes	Although we have not rigorously assessed the effect of sex on IOP in many strains, sex specific differences have not been detected in the majority of strains for which both sexes have been analyzed, and have proven inconsistent even within an individual strain analyzed multiple times.
T2118	12424-12432	IN	denotes	Although
T2120	12433-12435	PRP	denotes	we
T2121	12436-12440	VBP	denotes	have
T2122	12441-12444	RB	denotes	not
T2123	12445-12455	RB	denotes	rigorously
T2119	12456-12464	VBN	denotes	assessed
T2125	12465-12468	DT	denotes	the
T2126	12469-12475	NN	denotes	effect
T2127	12476-12478	IN	denotes	of
T2128	12479-12482	NN	denotes	sex
T2129	12483-12485	IN	denotes	on
T2130	12486-12489	NN	denotes	IOP
T2131	12490-12492	IN	denotes	in
T2132	12493-12497	JJ	denotes	many
T2133	12498-12505	NNS	denotes	strains
T2134	12505-12507	,	denotes	,
T2135	12507-12510	NN	denotes	sex
T2136	12511-12519	JJ	denotes	specific
T2137	12520-12531	NNS	denotes	differences
T2138	12532-12536	VBP	denotes	have
T2139	12537-12540	RB	denotes	not
T2140	12541-12545	VBN	denotes	been
T2124	12546-12554	VBN	denotes	detected
T2141	12555-12557	IN	denotes	in
T2142	12558-12561	DT	denotes	the
T2143	12562-12570	NN	denotes	majority
T2144	12571-12573	IN	denotes	of
T2145	12574-12581	NNS	denotes	strains
T2146	12582-12585	IN	denotes	for
T2148	12586-12591	WDT	denotes	which
T1954	12592-12596	DT	denotes	both
T1955	12597-12602	NNS	denotes	sexes
T1956	12603-12607	VBP	denotes	have
T1957	12608-12612	VBN	denotes	been
T2147	12613-12621	VBN	denotes	analyzed
T1958	12621-12623	,	denotes	,
T1959	12623-12626	CC	denotes	and
T1960	12627-12631	VBP	denotes	have
T1961	12632-12638	VBN	denotes	proven
T1962	12639-12651	JJ	denotes	inconsistent
T1963	12652-12656	RB	denotes	even
T1964	12657-12663	IN	denotes	within
T1965	12664-12666	DT	denotes	an
T1967	12667-12677	JJ	denotes	individual
T1966	12678-12684	NN	denotes	strain
T1968	12685-12693	VBN	denotes	analyzed
T1969	12694-12702	JJ	denotes	multiple
T1970	12703-12708	NNS	denotes	times
T1971	12708-12709	.	denotes	.
T1972	12709-12813	sentence	denotes	Strains B6 and 129P3/J have been extensively evaluated at multiple ages between 3 and 24 months of age.
T1973	12710-12717	NNS	denotes	Strains
T1974	12718-12720	NN	denotes	B6
T1976	12721-12724	CC	denotes	and
T1977	12725-12730	NN	denotes	129P3
T1979	12730-12731	HYPH	denotes	/
T1978	12731-12732	NN	denotes	J
T1980	12733-12737	VBP	denotes	have
T1982	12738-12742	VBN	denotes	been
T1983	12743-12754	RB	denotes	extensively
T1975	12755-12764	VBN	denotes	evaluated
T1985	12765-12767	IN	denotes	at
T1981	12768-12776	JJ	denotes	multiple
T1986	12777-12781	NNS	denotes	ages
T1987	12782-12789	IN	denotes	between
T1988	12790-12791	CD	denotes	3
T1990	12792-12795	CC	denotes	and
T1991	12796-12798	CD	denotes	24
T1989	12799-12805	NNS	denotes	months
T1992	12806-12808	IN	denotes	of
T1993	12809-12812	NN	denotes	age
T1994	12812-12813	.	denotes	.
T1995	12813-12901	sentence	denotes	Sex differences were always absent in strain 129P3/J and typically absent in strain B6.
T1996	12814-12817	NN	denotes	Sex
T1997	12818-12829	NNS	denotes	differences
T1998	12830-12834	VBD	denotes	were
T1999	12835-12841	RB	denotes	always
T2000	12842-12848	JJ	denotes	absent
T2001	12849-12851	IN	denotes	in
T2002	12852-12858	NN	denotes	strain
T2004	12859-12864	NN	denotes	129P3
T2005	12864-12865	HYPH	denotes	/
T2003	12865-12866	NN	denotes	J
T2006	12867-12870	CC	denotes	and
T2007	12871-12880	RB	denotes	typically
T2008	12881-12887	JJ	denotes	absent
T2009	12888-12890	IN	denotes	in
T2010	12891-12897	NN	denotes	strain
T2011	12898-12900	NN	denotes	B6
T2012	12900-12901	.	denotes	.
T2013	12901-12986	sentence	denotes	In strain B6, however, males infrequently had significantly higher IOP than females.
T2014	12902-12904	IN	denotes	In
T2016	12905-12911	NN	denotes	strain
T2017	12912-12914	NN	denotes	B6
T2018	12914-12916	,	denotes	,
T2019	12916-12923	RB	denotes	however
T2020	12923-12925	,	denotes	,
T2021	12925-12930	NNS	denotes	males
T2022	12931-12943	RB	denotes	infrequently
T2015	12944-12947	VBD	denotes	had
T2023	12948-12961	RB	denotes	significantly
T2024	12962-12968	JJR	denotes	higher
T2025	12969-12972	NN	denotes	IOP
T2026	12973-12977	IN	denotes	than
T2027	12978-12985	NNS	denotes	females
T2028	12985-12986	.	denotes	.
T2029	12986-13149	sentence	denotes	For example, in one experiment, B6 males had an average IOP of 14.2 ± 0.3 mmHg (n = 12) whereas the average IOP of females was 13.1 ± 0.3 mmHg (n = 12, P = 0.01).
T2030	12987-12990	IN	denotes	For
T2032	12991-12998	NN	denotes	example
T2033	12998-13000	,	denotes	,
T2034	13000-13002	IN	denotes	in
T2035	13003-13006	CD	denotes	one
T2036	13007-13017	NN	denotes	experiment
T2037	13017-13019	,	denotes	,
T2038	13019-13021	NN	denotes	B6
T2039	13022-13027	NNS	denotes	males
T2031	13028-13031	VBD	denotes	had
T2040	13032-13034	DT	denotes	an
T2042	13035-13042	JJ	denotes	average
T2041	13043-13046	NN	denotes	IOP
T2043	13047-13049	IN	denotes	of
T2044	13050-13054	CD	denotes	14.2
T2046	13055-13056	SYM	denotes	±
T2045	13057-13060	CD	denotes	0.3
T2047	13061-13065	NN	denotes	mmHg
T2048	13066-13067	-LRB-	denotes	(
T2050	13067-13068	NN	denotes	n
T2051	13069-13070	SYM	denotes	=
T2049	13071-13073	CD	denotes	12
T2052	13073-13074	-RRB-	denotes	)
T2053	13075-13082	IN	denotes	whereas
T2055	13083-13086	DT	denotes	the
T2057	13087-13094	JJ	denotes	average
T2056	13095-13098	NN	denotes	IOP
T1984	13099-13101	IN	denotes	of
T2058	13102-13109	NNS	denotes	females
T2054	13110-13113	VBD	denotes	was
T2059	13114-13118	CD	denotes	13.1
T2061	13119-13120	SYM	denotes	±
T2060	13121-13124	CD	denotes	0.3
T2062	13125-13129	NN	denotes	mmHg
T2063	13130-13131	-LRB-	denotes	(
T2065	13131-13132	NN	denotes	n
T2067	13133-13134	SYM	denotes	=
T2066	13135-13137	CD	denotes	12
T2068	13137-13139	,	denotes	,
T2069	13139-13140	NN	denotes	P
T2070	13141-13142	SYM	denotes	=
T2064	13143-13147	CD	denotes	0.01
T2071	13147-13148	-RRB-	denotes	)
T2072	13148-13149	.	denotes	.
T2073	13149-13340	sentence	denotes	If real, this sporadic sex difference was not dependent on age, sometimes occurring in a group of B6 mice at a particular age and sometimes not occurring in a separate group of the same age.
T2074	13150-13152	IN	denotes	If
T2075	13153-13157	JJ	denotes	real
T2077	13157-13159	,	denotes	,
T2078	13159-13163	DT	denotes	this
T2080	13164-13172	JJ	denotes	sporadic
T2081	13173-13176	NN	denotes	sex
T2079	13177-13187	NN	denotes	difference
T2076	13188-13191	VBD	denotes	was
T2082	13192-13195	RB	denotes	not
T2083	13196-13205	JJ	denotes	dependent
T2084	13206-13208	IN	denotes	on
T2085	13209-13212	NN	denotes	age
T2086	13212-13214	,	denotes	,
T2087	13214-13223	RB	denotes	sometimes
T2088	13224-13233	VBG	denotes	occurring
T2089	13234-13236	IN	denotes	in
T2090	13237-13238	DT	denotes	a
T2091	13239-13244	NN	denotes	group
T2092	13245-13247	IN	denotes	of
T2093	13248-13250	NN	denotes	B6
T2094	13251-13255	NNS	denotes	mice
T2095	13256-13258	IN	denotes	at
T2096	13259-13260	DT	denotes	a
T2098	13261-13271	JJ	denotes	particular
T2097	13272-13275	NN	denotes	age
T2099	13276-13279	CC	denotes	and
T2100	13280-13289	RB	denotes	sometimes
T2102	13290-13293	RB	denotes	not
T2101	13294-13303	VBG	denotes	occurring
T2103	13304-13306	IN	denotes	in
T2104	13307-13308	DT	denotes	a
T2106	13309-13317	JJ	denotes	separate
T2105	13318-13323	NN	denotes	group
T2107	13324-13326	IN	denotes	of
T2108	13327-13330	DT	denotes	the
T2110	13331-13335	JJ	denotes	same
T2109	13336-13339	NN	denotes	age
T2111	13339-13340	.	denotes	.
T2161	13342-13352	NN	denotes	Anesthesia
T2162	13353-13361	NN	denotes	protocol
T2163	13362-13368	VBZ	denotes	avoids
T2164	13369-13372	NN	denotes	IOP
T2165	13373-13383	NN	denotes	alteration
T2166	13384-13387	CC	denotes	and
T2167	13388-13394	VBZ	denotes	allows
T2168	13395-13404	NN	denotes	detection
T2169	13405-13407	IN	denotes	of
T2170	13408-13415	JJ	denotes	diurnal
T2171	13416-13427	NNS	denotes	differences
T2172	13427-13536	sentence	denotes	All IOPs were assessed using an anesthetic regime of 99 mg/kg ketamine and 9 mg/kg xylazine (defined as 1X).
T2173	13428-13431	DT	denotes	All
T2174	13432-13436	NNS	denotes	IOPs
T2176	13437-13441	VBD	denotes	were
T2175	13442-13450	VBN	denotes	assessed
T2177	13451-13456	VBG	denotes	using
T2178	13457-13459	DT	denotes	an
T2180	13460-13470	JJ	denotes	anesthetic
T2179	13471-13477	NN	denotes	regime
T2181	13478-13480	IN	denotes	of
T2182	13481-13483	CD	denotes	99
T2183	13484-13486	NNS	denotes	mg
T2185	13486-13487	SYM	denotes	/
T2186	13487-13489	NN	denotes	kg
T2184	13490-13498	NN	denotes	ketamine
T2187	13499-13502	CC	denotes	and
T2188	13503-13504	CD	denotes	9
T2189	13505-13507	NNS	denotes	mg
T2191	13507-13508	SYM	denotes	/
T2192	13508-13510	NN	denotes	kg
T2190	13511-13519	NN	denotes	xylazine
T2193	13520-13521	-LRB-	denotes	(
T2194	13521-13528	VBN	denotes	defined
T2195	13529-13531	IN	denotes	as
T2196	13532-13534	NN	denotes	1X
T2197	13534-13535	-RRB-	denotes	)
T2198	13535-13536	.	denotes	.
T2199	13536-13806	sentence	denotes	Initial experiments suggested that an almost identical dose (100 mg/kg ketamine and 9 mg/kg xylazine) of anesthesia had no effect on IOP during the experimental period with IOP being measured as soon as possible after the mouse was unconscious, typically minutes. [13].
T2200	13537-13544	JJ	denotes	Initial
T2201	13545-13556	NNS	denotes	experiments
T2202	13557-13566	VBD	denotes	suggested
T2203	13567-13571	IN	denotes	that
T2205	13572-13574	DT	denotes	an
T2207	13575-13581	RB	denotes	almost
T2208	13582-13591	JJ	denotes	identical
T2206	13592-13596	NN	denotes	dose
T2209	13597-13598	-LRB-	denotes	(
T2210	13598-13601	CD	denotes	100
T2211	13602-13604	NNS	denotes	mg
T2213	13604-13605	SYM	denotes	/
T2214	13605-13607	NN	denotes	kg
T2212	13608-13616	NN	denotes	ketamine
T2215	13617-13620	CC	denotes	and
T2216	13621-13622	CD	denotes	9
T2217	13623-13625	NNS	denotes	mg
T2219	13625-13626	SYM	denotes	/
T2220	13626-13628	NN	denotes	kg
T2218	13629-13637	NN	denotes	xylazine
T2221	13637-13638	-RRB-	denotes	)
T2222	13639-13641	IN	denotes	of
T2223	13642-13652	NN	denotes	anesthesia
T2204	13653-13656	VBD	denotes	had
T2224	13657-13659	DT	denotes	no
T2225	13660-13666	NN	denotes	effect
T2226	13667-13669	IN	denotes	on
T2227	13670-13673	NN	denotes	IOP
T2228	13674-13680	IN	denotes	during
T2229	13681-13684	DT	denotes	the
T2231	13685-13697	JJ	denotes	experimental
T2230	13698-13704	NN	denotes	period
T2232	13705-13709	IN	denotes	with
T2233	13710-13713	NN	denotes	IOP
T2235	13714-13719	VBG	denotes	being
T2234	13720-13728	VBN	denotes	measured
T2236	13729-13731	RB	denotes	as
T2237	13732-13736	RB	denotes	soon
T2238	13737-13739	IN	denotes	as
T2239	13740-13748	JJ	denotes	possible
T2240	13749-13754	IN	denotes	after
T2242	13755-13758	DT	denotes	the
T2243	13759-13764	NN	denotes	mouse
T2241	13765-13768	VBD	denotes	was
T2244	13769-13780	JJ	denotes	unconscious
T2245	13780-13782	,	denotes	,
T2246	13782-13791	RB	denotes	typically
T2247	13792-13799	NNS	denotes	minutes
T2248	13799-13800	.	denotes	.
T2249	13801-13802	-LRB-	denotes	[
T2250	13802-13804	CD	denotes	13
T2251	13804-13805	-RRB-	denotes	]
T2252	13805-13806	.	denotes	.
T2253	13806-14010	sentence	denotes	To further assess the effects of anesthesia, we measured IOP in groups of genetically identical B6 mice subjected to different doses (1X, 1.5X and 2X) at 5 and 25 minutes after administration (Figure 5).
T2254	13807-13809	TO	denotes	To
T2256	13810-13817	RB	denotes	further
T2255	13818-13824	VB	denotes	assess
T2258	13825-13828	DT	denotes	the
T2259	13829-13836	NNS	denotes	effects
T2260	13837-13839	IN	denotes	of
T2261	13840-13850	NN	denotes	anesthesia
T2262	13850-13852	,	denotes	,
T2263	13852-13854	PRP	denotes	we
T2257	13855-13863	VBD	denotes	measured
T2264	13864-13867	NN	denotes	IOP
T2265	13868-13870	IN	denotes	in
T2266	13871-13877	NNS	denotes	groups
T2267	13878-13880	IN	denotes	of
T2268	13881-13892	RB	denotes	genetically
T2269	13893-13902	JJ	denotes	identical
T2271	13903-13905	NN	denotes	B6
T2270	13906-13910	NNS	denotes	mice
T2272	13911-13920	VBN	denotes	subjected
T2273	13921-13923	IN	denotes	to
T2274	13924-13933	JJ	denotes	different
T2275	13934-13939	NNS	denotes	doses
T2276	13940-13941	-LRB-	denotes	(
T2277	13941-13943	NN	denotes	1X
T2278	13943-13945	,	denotes	,
T2279	13945-13949	NN	denotes	1.5X
T2280	13950-13953	CC	denotes	and
T2281	13954-13956	NN	denotes	2X
T2282	13956-13957	-RRB-	denotes	)
T2283	13958-13960	IN	denotes	at
T2284	13961-13962	CD	denotes	5
T2286	13963-13966	CC	denotes	and
T2287	13967-13969	CD	denotes	25
T2285	13970-13977	NNS	denotes	minutes
T2288	13978-13983	IN	denotes	after
T2289	13984-13998	NN	denotes	administration
T2290	13999-14000	-LRB-	denotes	(
T2291	14000-14006	NN	denotes	Figure
T2292	14007-14008	CD	denotes	5
T2293	14008-14009	-RRB-	denotes	)
T2294	14009-14010	.	denotes	.
T2295	14010-14075	sentence	denotes	For all doses, IOP decreased by 25 minutes (P = 0.005 for time).
T2296	14011-14014	IN	denotes	For
T2298	14015-14018	DT	denotes	all
T2299	14019-14024	NNS	denotes	doses
T2300	14024-14026	,	denotes	,
T2301	14026-14029	NN	denotes	IOP
T2297	14030-14039	VBD	denotes	decreased
T2302	14040-14042	IN	denotes	by
T2303	14043-14045	CD	denotes	25
T2304	14046-14053	NNS	denotes	minutes
T2305	14054-14055	-LRB-	denotes	(
T2307	14055-14056	NN	denotes	P
T2308	14057-14058	SYM	denotes	=
T2306	14059-14064	CD	denotes	0.005
T2309	14065-14068	IN	denotes	for
T2310	14069-14073	NN	denotes	time
T2311	14073-14074	-RRB-	denotes	)
T2312	14074-14075	.	denotes	.
T2313	14075-14129	sentence	denotes	The greater the dose the greater the decrease in IOP.
T2314	14076-14079	DT	denotes	The
T2315	14080-14087	JJR	denotes	greater
T2317	14088-14091	DT	denotes	the
T2318	14092-14096	NN	denotes	dose
T2319	14097-14100	DT	denotes	the
T2320	14101-14108	JJR	denotes	greater
T2321	14109-14112	DT	denotes	the
T2316	14113-14121	NN	denotes	decrease
T2322	14122-14124	IN	denotes	in
T2323	14125-14128	NN	denotes	IOP
T2324	14128-14129	.	denotes	.
T2325	14129-14267	sentence	denotes	At the 5 minute measurement, however, IOP was the same using all doses suggesting that the anesthetic effect on IOP had not yet occurred.
T2326	14130-14132	IN	denotes	At
T2328	14133-14136	DT	denotes	the
T2330	14137-14138	CD	denotes	5
T2331	14139-14145	JJ	denotes	minute
T2329	14146-14157	NN	denotes	measurement
T2332	14157-14159	,	denotes	,
T2333	14159-14166	RB	denotes	however
T2334	14166-14168	,	denotes	,
T2335	14168-14171	NN	denotes	IOP
T2327	14172-14175	VBD	denotes	was
T2336	14176-14179	DT	denotes	the
T2337	14180-14184	JJ	denotes	same
T2338	14185-14190	VBG	denotes	using
T2339	14191-14194	DT	denotes	all
T2340	14195-14200	NNS	denotes	doses
T2341	14201-14211	VBG	denotes	suggesting
T2342	14212-14216	IN	denotes	that
T2344	14217-14220	DT	denotes	the
T2346	14221-14231	JJ	denotes	anesthetic
T2345	14232-14238	NN	denotes	effect
T2347	14239-14241	IN	denotes	on
T2348	14242-14245	NN	denotes	IOP
T2349	14246-14249	VBD	denotes	had
T2350	14250-14253	RB	denotes	not
T2351	14254-14257	RB	denotes	yet
T2343	14258-14266	VBN	denotes	occurred
T2352	14266-14267	.	denotes	.
T2353	14267-14532	sentence	denotes	To identify any early window when it may be possible to assess IOP without an obvious anesthetic effect, 195 mice of strain B6 were anesthetized with the 1X dose and IOP was measured at 1 minute time points between 4 and 12 minutes after administration (Figure 5).
T2354	14268-14270	TO	denotes	To
T2355	14271-14279	VB	denotes	identify
T2357	14280-14283	DT	denotes	any
T2359	14284-14289	JJ	denotes	early
T2358	14290-14296	NN	denotes	window
T2360	14297-14301	WRB	denotes	when
T2362	14302-14304	PRP	denotes	it
T2363	14305-14308	MD	denotes	may
T2361	14309-14311	VB	denotes	be
T2364	14312-14320	JJ	denotes	possible
T2365	14321-14323	TO	denotes	to
T2366	14324-14330	VB	denotes	assess
T2367	14331-14334	NN	denotes	IOP
T2368	14335-14342	IN	denotes	without
T2369	14343-14345	DT	denotes	an
T2371	14346-14353	JJ	denotes	obvious
T2372	14354-14364	JJ	denotes	anesthetic
T2370	14365-14371	NN	denotes	effect
T2373	14371-14373	,	denotes	,
T2374	14373-14376	CD	denotes	195
T2375	14377-14381	NNS	denotes	mice
T2376	14382-14384	IN	denotes	of
T2377	14385-14391	NN	denotes	strain
T2378	14392-14394	NN	denotes	B6
T2379	14395-14399	VBD	denotes	were
T2356	14400-14412	VBN	denotes	anesthetized
T2380	14413-14417	IN	denotes	with
T2381	14418-14421	DT	denotes	the
T2383	14422-14424	NN	denotes	1X
T2382	14425-14429	NN	denotes	dose
T2384	14430-14433	CC	denotes	and
T2385	14434-14437	NN	denotes	IOP
T2387	14438-14441	VBD	denotes	was
T2386	14442-14450	VBN	denotes	measured
T2388	14451-14453	IN	denotes	at
T2389	14454-14455	CD	denotes	1
T2390	14456-14462	NN	denotes	minute
T2392	14463-14467	NN	denotes	time
T2391	14468-14474	NNS	denotes	points
T2393	14475-14482	IN	denotes	between
T2394	14483-14484	CD	denotes	4
T2396	14485-14488	CC	denotes	and
T2397	14489-14491	CD	denotes	12
T2395	14492-14499	NNS	denotes	minutes
T2398	14500-14505	IN	denotes	after
T2399	14506-14520	NN	denotes	administration
T2400	14521-14522	-LRB-	denotes	(
T2401	14522-14528	NN	denotes	Figure
T2402	14529-14530	CD	denotes	5
T2403	14530-14531	-RRB-	denotes	)
T2404	14531-14532	.	denotes	.
T2405	14532-14715	sentence	denotes	The mean IOP of groups analyzed at each time point did not differ (P = 0.9) indicating that the IOP depressing effect of anesthesia occurs later than 12 minutes after administration.
T2406	14533-14536	DT	denotes	The
T2408	14537-14541	JJ	denotes	mean
T2407	14542-14545	NN	denotes	IOP
T2410	14546-14548	IN	denotes	of
T2411	14549-14555	NNS	denotes	groups
T2412	14556-14564	VBN	denotes	analyzed
T2413	14565-14567	IN	denotes	at
T2414	14568-14572	DT	denotes	each
T2416	14573-14577	NN	denotes	time
T2415	14578-14583	NN	denotes	point
T2417	14584-14587	VBD	denotes	did
T2418	14588-14591	RB	denotes	not
T2409	14592-14598	VB	denotes	differ
T2419	14599-14600	-LRB-	denotes	(
T2421	14600-14601	NN	denotes	P
T2422	14602-14603	SYM	denotes	=
T2420	14604-14607	CD	denotes	0.9
T2423	14607-14608	-RRB-	denotes	)
T2424	14609-14619	VBG	denotes	indicating
T2425	14620-14624	IN	denotes	that
T2427	14625-14628	DT	denotes	the
T2429	14629-14632	NN	denotes	IOP
T2430	14633-14643	VBG	denotes	depressing
T2428	14644-14650	NN	denotes	effect
T2431	14651-14653	IN	denotes	of
T2432	14654-14664	NN	denotes	anesthesia
T2426	14665-14671	VBZ	denotes	occurs
T2433	14672-14677	RB	denotes	later
T2434	14678-14682	IN	denotes	than
T2435	14683-14685	CD	denotes	12
T2436	14686-14693	NNS	denotes	minutes
T2437	14694-14699	IN	denotes	after
T2438	14700-14714	NN	denotes	administration
T2439	14714-14715	.	denotes	.
T2440	14715-14851	sentence	denotes	Similar results were obtained using 161 strain 129P3/J and 145 strain DBA/2J mice with the 1X dose (129P3/J, P = 0.1; DBA/2J, P = 0.2).
T2441	14716-14723	JJ	denotes	Similar
T2442	14724-14731	NNS	denotes	results
T2444	14732-14736	VBD	denotes	were
T2443	14737-14745	VBN	denotes	obtained
T2445	14746-14751	VBG	denotes	using
T2446	14752-14755	CD	denotes	161
T2448	14756-14762	NN	denotes	strain
T2449	14763-14768	NN	denotes	129P3
T2450	14768-14769	HYPH	denotes	/
T2447	14769-14770	NN	denotes	J
T2452	14771-14774	CC	denotes	and
T2453	14775-14778	CD	denotes	145
T2455	14779-14785	NN	denotes	strain
T2456	14786-14789	NN	denotes	DBA
T2457	14789-14790	HYPH	denotes	/
T2454	14790-14792	NN	denotes	2J
T2451	14793-14797	NNS	denotes	mice
T2458	14798-14802	IN	denotes	with
T2459	14803-14806	DT	denotes	the
T2461	14807-14809	NN	denotes	1X
T2460	14810-14814	NN	denotes	dose
T2462	14815-14816	-LRB-	denotes	(
T2464	14816-14821	NN	denotes	129P3
T2466	14821-14822	HYPH	denotes	/
T2465	14822-14823	NN	denotes	J
T2468	14823-14825	,	denotes	,
T2469	14825-14826	NN	denotes	P
T2470	14827-14828	SYM	denotes	=
T2467	14829-14832	CD	denotes	0.1
T2471	14832-14833	:	denotes	;
T2472	14834-14837	NN	denotes	DBA
T2474	14837-14838	HYPH	denotes	/
T2473	14838-14840	NN	denotes	2J
T2475	14840-14842	,	denotes	,
T2476	14842-14843	NN	denotes	P
T2477	14844-14845	SYM	denotes	=
T2463	14846-14849	CD	denotes	0.2
T2478	14849-14850	-RRB-	denotes	)
T2479	14850-14851	.	denotes	.
T2480	14851-15094	sentence	denotes	In support of a later effect of anesthesia (since general anesthesia is reported to mask diurnal variation in IOP [21]), we identified increased IOP during the dark compared to the light period of the day in several tested strains (Figure 6).
T2481	14852-14854	IN	denotes	In
T2483	14855-14862	NN	denotes	support
T2484	14863-14865	IN	denotes	of
T2485	14866-14867	DT	denotes	a
T2487	14868-14873	JJ	denotes	later
T2486	14874-14880	NN	denotes	effect
T2488	14881-14883	IN	denotes	of
T2489	14884-14894	NN	denotes	anesthesia
T2490	14895-14896	-LRB-	denotes	(
T2491	14896-14901	IN	denotes	since
T2493	14902-14909	JJ	denotes	general
T2494	14910-14920	NN	denotes	anesthesia
T2495	14921-14923	VBZ	denotes	is
T2492	14924-14932	VBN	denotes	reported
T2496	14933-14935	TO	denotes	to
T2497	14936-14940	VB	denotes	mask
T2498	14941-14948	JJ	denotes	diurnal
T2499	14949-14958	NN	denotes	variation
T2500	14959-14961	IN	denotes	in
T2501	14962-14965	NN	denotes	IOP
T2502	14966-14967	-LRB-	denotes	[
T2503	14967-14969	CD	denotes	21
T2504	14969-14970	-RRB-	denotes	]
T2505	14970-14971	-RRB-	denotes	)
T2506	14971-14973	,	denotes	,
T2507	14973-14975	PRP	denotes	we
T2482	14976-14986	VBD	denotes	identified
T2508	14987-14996	VBN	denotes	increased
T2509	14997-15000	NN	denotes	IOP
T2510	15001-15007	IN	denotes	during
T2511	15008-15011	DT	denotes	the
T2512	15012-15016	NN	denotes	dark
T2513	15017-15025	VBN	denotes	compared
T2514	15026-15028	IN	denotes	to
T2515	15029-15032	DT	denotes	the
T2516	15033-15038	JJ	denotes	light
T2517	15039-15045	NN	denotes	period
T2518	15046-15048	IN	denotes	of
T2519	15049-15052	DT	denotes	the
T2520	15053-15056	NN	denotes	day
T2521	15057-15059	IN	denotes	in
T2522	15060-15067	JJ	denotes	several
T2524	15068-15074	VBN	denotes	tested
T2523	15075-15082	NNS	denotes	strains
T2525	15083-15084	-LRB-	denotes	(
T2526	15084-15090	NN	denotes	Figure
T2527	15091-15092	CD	denotes	6
T2528	15092-15093	-RRB-	denotes	)
T2529	15093-15094	.	denotes	.
T2530	15094-15204	sentence	denotes	In these experiments, IOP measurements were made between 5 and 12 minutes after administration of anesthesia.
T2531	15095-15097	IN	denotes	In
T2533	15098-15103	DT	denotes	these
T2534	15104-15115	NNS	denotes	experiments
T2535	15115-15117	,	denotes	,
T2536	15117-15120	NN	denotes	IOP
T2537	15121-15133	NNS	denotes	measurements
T2538	15134-15138	VBD	denotes	were
T2532	15139-15143	VBN	denotes	made
T2539	15144-15151	IN	denotes	between
T2540	15152-15153	CD	denotes	5
T2542	15154-15157	CC	denotes	and
T2543	15158-15160	CD	denotes	12
T2541	15161-15168	NNS	denotes	minutes
T2544	15169-15174	IN	denotes	after
T2545	15175-15189	NN	denotes	administration
T2546	15190-15192	IN	denotes	of
T2547	15193-15203	NN	denotes	anesthesia
T2548	15203-15204	.	denotes	.
T8421	15215-15217	DT	denotes	No
T8422	15218-15224	NN	denotes	effect
T8423	15225-15227	IN	denotes	of
T8424	15228-15230	NN	denotes	1X
T8426	15231-15241	JJ	denotes	anesthetic
T8425	15242-15246	NN	denotes	dose
T8427	15247-15253	IN	denotes	within
T8428	15254-15256	CD	denotes	12
T8429	15257-15264	NNS	denotes	minutes
T8430	15265-15267	IN	denotes	of
T8431	15268-15282	NN	denotes	administration
T8432	15282-15283	.	denotes	.
T8433	15283-15399	sentence	denotes	A Mean IOP ± SD is shown for C57BL/6J mice at 5 and 25 minutes after administration of various doses of anesthetic.
T8434	15284-15285	DT	denotes	A
T8436	15286-15290	NN	denotes	Mean
T8435	15291-15294	NN	denotes	IOP
T8438	15295-15296	SYM	denotes	±
T8439	15297-15299	NN	denotes	SD
T8440	15300-15302	VBZ	denotes	is
T8437	15303-15308	VBN	denotes	shown
T8441	15309-15312	IN	denotes	for
T8442	15313-15318	NN	denotes	C57BL
T8444	15318-15319	HYPH	denotes	/
T8443	15319-15321	NN	denotes	6J
T8445	15322-15326	NNS	denotes	mice
T8446	15327-15329	IN	denotes	at
T8447	15330-15331	CD	denotes	5
T8449	15332-15335	CC	denotes	and
T8450	15336-15338	CD	denotes	25
T8448	15339-15346	NNS	denotes	minutes
T8451	15347-15352	IN	denotes	after
T8452	15353-15367	NN	denotes	administration
T8453	15368-15370	IN	denotes	of
T8454	15371-15378	JJ	denotes	various
T8455	15379-15384	NNS	denotes	doses
T8456	15385-15387	IN	denotes	of
T8457	15388-15398	NN	denotes	anesthetic
T8458	15398-15399	.	denotes	.
T8459	15399-15464	sentence	denotes	The 1X dose consisted of 99 mg/kg ketamine and 9 mg/kg xylazine.
T8460	15400-15403	DT	denotes	The
T8462	15404-15406	NN	denotes	1X
T8461	15407-15411	NN	denotes	dose
T8463	15412-15421	VBD	denotes	consisted
T8464	15422-15424	IN	denotes	of
T8465	15425-15427	CD	denotes	99
T8466	15428-15430	NNS	denotes	mg
T8468	15430-15431	SYM	denotes	/
T8469	15431-15433	NNS	denotes	kg
T8467	15434-15442	NN	denotes	ketamine
T8470	15443-15446	CC	denotes	and
T8471	15447-15448	CD	denotes	9
T8472	15449-15451	NNS	denotes	mg
T8474	15451-15452	SYM	denotes	/
T8475	15452-15454	NN	denotes	kg
T8473	15455-15463	NN	denotes	xylazine
T8476	15463-15464	.	denotes	.
T8477	15464-15503	sentence	denotes	All doses decreased IOP by 25 minutes.
T8478	15465-15468	DT	denotes	All
T8479	15469-15474	NNS	denotes	doses
T8480	15475-15484	VBD	denotes	decreased
T8481	15485-15488	NN	denotes	IOP
T8482	15489-15491	IN	denotes	by
T8483	15492-15494	CD	denotes	25
T8484	15495-15502	NNS	denotes	minutes
T8485	15502-15503	.	denotes	.
T8486	15503-15613	sentence	denotes	At all doses the IOP at 5 minutes was the same suggesting that the effect of anesthesia had not yet occurred.
T8487	15504-15506	IN	denotes	At
T8489	15507-15510	DT	denotes	all
T8490	15511-15516	NNS	denotes	doses
T8491	15517-15520	DT	denotes	the
T8492	15521-15524	NN	denotes	IOP
T8493	15525-15527	IN	denotes	at
T8494	15528-15529	CD	denotes	5
T8495	15530-15537	NNS	denotes	minutes
T8488	15538-15541	VBD	denotes	was
T8496	15542-15545	DT	denotes	the
T8497	15546-15550	JJ	denotes	same
T8498	15551-15561	VBG	denotes	suggesting
T8499	15562-15566	IN	denotes	that
T8501	15567-15570	DT	denotes	the
T8502	15571-15577	NN	denotes	effect
T8503	15578-15580	IN	denotes	of
T8504	15581-15591	NN	denotes	anesthesia
T8505	15592-15595	VBD	denotes	had
T8506	15596-15599	RB	denotes	not
T8507	15600-15603	RB	denotes	yet
T8500	15604-15612	VBN	denotes	occurred
T8508	15612-15613	.	denotes	.
T8509	15613-15697	sentence	denotes	Approximately thirty 3 to 4 month old mice were analyzed at each dose and time B-D.
T8510	15614-15627	RB	denotes	Approximately
T8511	15628-15634	CD	denotes	thirty
T8513	15635-15636	CD	denotes	3
T8515	15637-15639	IN	denotes	to
T8514	15640-15641	CD	denotes	4
T8516	15642-15647	NN	denotes	month
T8517	15648-15651	JJ	denotes	old
T8512	15652-15656	NNS	denotes	mice
T8519	15657-15661	VBD	denotes	were
T8518	15662-15670	VBN	denotes	analyzed
T8520	15671-15673	IN	denotes	at
T8521	15674-15678	DT	denotes	each
T8522	15679-15683	NN	denotes	dose
T8523	15684-15687	CC	denotes	and
T8524	15688-15692	NN	denotes	time
T8525	15693-15694	NN	denotes	B
T8526	15694-15695	SYM	denotes	-
T8527	15695-15696	NN	denotes	D
T8528	15696-15697	.	denotes	.
T8529	15697-15843	sentence	denotes	Scatter-plots demonstrating no change in IOP over the 12 minutes following anesthetic administration in three relatively unrelated mouse strains.
T8530	15698-15705	NN	denotes	Scatter
T8532	15705-15706	HYPH	denotes	-
T8531	15706-15711	NNS	denotes	plots
T8533	15712-15725	VBG	denotes	demonstrating
T8534	15726-15728	DT	denotes	no
T8535	15729-15735	NN	denotes	change
T8536	15736-15738	IN	denotes	in
T8537	15739-15742	NN	denotes	IOP
T8538	15743-15747	IN	denotes	over
T8539	15748-15751	DT	denotes	the
T8541	15752-15754	CD	denotes	12
T8540	15755-15762	NNS	denotes	minutes
T8542	15763-15772	VBG	denotes	following
T8543	15773-15783	NN	denotes	anesthetic
T8544	15784-15798	NN	denotes	administration
T8545	15799-15801	IN	denotes	in
T8546	15802-15807	CD	denotes	three
T8548	15808-15818	RB	denotes	relatively
T8549	15819-15828	JJ	denotes	unrelated
T8550	15829-15834	NN	denotes	mouse
T8547	15835-15842	NNS	denotes	strains
T8551	15842-15843	.	denotes	.
T8552	15843-15925	sentence	denotes	All strains consisted of males and females that ranged from 3 to 6 months of age.
T8553	15844-15847	DT	denotes	All
T8554	15848-15855	NNS	denotes	strains
T8555	15856-15865	VBD	denotes	consisted
T8556	15866-15868	IN	denotes	of
T8557	15869-15874	NNS	denotes	males
T8558	15875-15878	CC	denotes	and
T8559	15879-15886	NNS	denotes	females
T8560	15887-15891	WDT	denotes	that
T8561	15892-15898	VBD	denotes	ranged
T8562	15899-15903	IN	denotes	from
T8563	15904-15905	CD	denotes	3
T8564	15906-15908	IN	denotes	to
T8565	15909-15910	CD	denotes	6
T8566	15911-15917	NNS	denotes	months
T8567	15918-15920	IN	denotes	of
T8568	15921-15924	NN	denotes	age
T8569	15924-15925	.	denotes	.
T8570	15925-15989	sentence	denotes	The sexes and ages were equally represented at each time point.
T8571	15926-15929	DT	denotes	The
T8572	15930-15935	NNS	denotes	sexes
T8574	15936-15939	CC	denotes	and
T8575	15940-15944	NNS	denotes	ages
T8573	15945-15949	VBD	denotes	were
T8576	15950-15957	RB	denotes	equally
T8577	15958-15969	JJ	denotes	represented
T8578	15970-15972	IN	denotes	at
T8579	15973-15977	DT	denotes	each
T8581	15978-15982	NN	denotes	time
T8580	15983-15988	NN	denotes	point
T8582	15988-15989	.	denotes	.
T8583	15989-16062	sentence	denotes	The scatter-plots include 195 C57BL/6J, 161 129P3/J and 145 DBA/2J mice.
T8584	15990-15993	DT	denotes	The
T8586	15994-16001	NN	denotes	scatter
T8587	16001-16002	HYPH	denotes	-
T8585	16002-16007	NNS	denotes	plots
T8588	16008-16015	VBP	denotes	include
T8589	16016-16019	CD	denotes	195
T8591	16020-16025	NN	denotes	C57BL
T8592	16025-16026	HYPH	denotes	/
T8590	16026-16028	NN	denotes	6J
T8594	16028-16030	,	denotes	,
T8595	16030-16033	CD	denotes	161
T8597	16034-16039	NN	denotes	129P3
T8598	16039-16040	HYPH	denotes	/
T8596	16040-16041	NN	denotes	J
T8599	16042-16045	CC	denotes	and
T8600	16046-16049	CD	denotes	145
T8602	16050-16053	NN	denotes	DBA
T8603	16053-16054	HYPH	denotes	/
T8601	16054-16056	NN	denotes	2J
T8593	16057-16061	NNS	denotes	mice
T8604	16061-16062	.	denotes	.
T8625	16073-16076	NN	denotes	IOP
T8627	16077-16079	VBZ	denotes	is
T8626	16080-16089	VBN	denotes	increased
T8628	16090-16096	IN	denotes	during
T8629	16097-16100	DT	denotes	the
T8630	16101-16105	NN	denotes	dark
T8631	16106-16114	VBN	denotes	compared
T8632	16115-16117	IN	denotes	to
T8633	16118-16123	JJ	denotes	light
T8634	16124-16131	NNS	denotes	periods
T8635	16132-16134	IN	denotes	in
T8636	16135-16142	JJ	denotes	several
T8637	16143-16150	NNS	denotes	strains
T8638	16150-16151	.	denotes	.
T8639	16151-16288	sentence	denotes	Mean IOP ± SEM is shown for the indicated strains at measurement during the light (open bars) or dark (filled bars) periods of the day.
T8650	16203-16205	IN	denotes	at
T8651	16206-16217	NN	denotes	measurement
T8652	16218-16224	IN	denotes	during
T8653	16225-16228	DT	denotes	the
T8655	16229-16234	NN	denotes	light
T8656	16235-16236	-LRB-	denotes	(
T8658	16236-16240	JJ	denotes	open
T8657	16241-16245	NNS	denotes	bars
T8659	16245-16246	-RRB-	denotes	)
T8660	16247-16249	CC	denotes	or
T8661	16250-16254	JJ	denotes	dark
T8662	16255-16256	-LRB-	denotes	(
T8664	16256-16262	VBN	denotes	filled
T8663	16263-16267	NNS	denotes	bars
T8665	16267-16268	-RRB-	denotes	)
T8654	16269-16276	NNS	denotes	periods
T8666	16277-16279	IN	denotes	of
T8667	16280-16283	DT	denotes	the
T8668	16284-16287	NN	denotes	day
T8669	16287-16288	.	denotes	.
T8670	16288-16368	sentence	denotes	All mice were 2 to 4 months old except for CBA/CaJ that were 5 to 6 months old.
T8671	16289-16292	DT	denotes	All
T8672	16293-16297	NNS	denotes	mice
T8673	16298-16302	VBD	denotes	were
T8674	16303-16304	CD	denotes	2
T8676	16305-16307	IN	denotes	to
T8675	16308-16309	CD	denotes	4
T8677	16310-16316	NNS	denotes	months
T8678	16317-16320	JJ	denotes	old
T8679	16321-16327	IN	denotes	except
T8680	16328-16331	IN	denotes	for
T8681	16332-16335	NN	denotes	CBA
T8683	16335-16336	HYPH	denotes	/
T8682	16336-16339	NN	denotes	CaJ
T8684	16340-16344	WDT	denotes	that
T8685	16345-16349	VBD	denotes	were
T8686	16350-16351	CD	denotes	5
T8688	16352-16354	IN	denotes	to
T8687	16355-16356	CD	denotes	6
T8689	16357-16363	NNS	denotes	months
T8690	16364-16367	JJ	denotes	old
T8691	16367-16368	.	denotes	.
T8692	16368-16435	sentence	denotes	129B6 refers to mice of a mixed 129X1/SvJ and C57BL/6J background.
T8693	16369-16374	CD	denotes	129B6
T8694	16375-16381	VBZ	denotes	refers
T8695	16382-16384	IN	denotes	to
T8696	16385-16389	NNS	denotes	mice
T8697	16390-16392	IN	denotes	of
T8698	16393-16394	DT	denotes	a
T8700	16395-16400	JJ	denotes	mixed
T8701	16401-16406	NN	denotes	129X1
T8703	16406-16407	HYPH	denotes	/
T8702	16407-16410	NN	denotes	SvJ
T8704	16411-16414	CC	denotes	and
T8705	16415-16420	NN	denotes	C57BL
T8707	16420-16421	HYPH	denotes	/
T8706	16421-16423	NN	denotes	6J
T8699	16424-16434	NN	denotes	background
T8708	16434-16435	.	denotes	.
T8709	16435-16500	sentence	denotes	IOP was increased during the dark in all strains except CBA/CaJ.
T8710	16436-16439	NN	denotes	IOP
T8712	16440-16443	VBD	denotes	was
T8711	16444-16453	VBN	denotes	increased
T8713	16454-16460	IN	denotes	during
T8714	16461-16464	DT	denotes	the
T8715	16465-16469	NN	denotes	dark
T8716	16470-16472	IN	denotes	in
T8717	16473-16476	DT	denotes	all
T8718	16477-16484	NNS	denotes	strains
T8719	16485-16491	IN	denotes	except
T8720	16492-16495	NN	denotes	CBA
T8722	16495-16496	HYPH	denotes	/
T8721	16496-16499	NN	denotes	CaJ
T8723	16499-16500	.	denotes	.
T8724	16500-16715	sentence	denotes	The number of mice successfully analyzed during the light (L) or dark (D) periods follows, DBA/2J 10L,10D; C57BL/6J 32L, 22D; C57BR/cdJ 12L,10D; SWR/J 16L, 16D; BALB/cByJ 15L, 16D; 129B6 10L, 12D; CBA/CaJ 22L, 16D.
T8725	16501-16504	DT	denotes	The
T8726	16505-16511	NN	denotes	number
T8728	16512-16514	IN	denotes	of
T8729	16515-16519	NNS	denotes	mice
T8730	16520-16532	RB	denotes	successfully
T8731	16533-16541	VBN	denotes	analyzed
T8732	16542-16548	IN	denotes	during
T8733	16549-16552	DT	denotes	the
T8735	16553-16558	JJ	denotes	light
T8737	16559-16560	-LRB-	denotes	(
T8736	16560-16561	JJ	denotes	L
T8738	16561-16562	-RRB-	denotes	)
T8739	16563-16565	CC	denotes	or
T8740	16566-16570	JJ	denotes	dark
T8742	16571-16572	-LRB-	denotes	(
T8741	16572-16573	JJ	denotes	D
T8743	16573-16574	-RRB-	denotes	)
T8734	16575-16582	NNS	denotes	periods
T8727	16583-16590	VBZ	denotes	follows
T8744	16590-16592	,	denotes	,
T8745	16592-16595	NN	denotes	DBA
T8747	16595-16596	HYPH	denotes	/
T8746	16596-16598	NN	denotes	2J
T8749	16599-16602	NN	denotes	10L
T8750	16602-16603	,	denotes	,
T8748	16603-16606	NN	denotes	10D
T8752	16606-16607	:	denotes	;
T8753	16608-16613	NN	denotes	C57BL
T8755	16613-16614	HYPH	denotes	/
T8754	16614-16616	NN	denotes	6J
T8757	16617-16620	NN	denotes	32L
T8758	16620-16622	,	denotes	,
T8756	16622-16625	NN	denotes	22D
T8759	16625-16626	:	denotes	;
T8760	16627-16632	NN	denotes	C57BR
T8762	16632-16633	HYPH	denotes	/
T8761	16633-16636	NN	denotes	cdJ
T8764	16637-16640	NN	denotes	12L
T8765	16640-16641	,	denotes	,
T8763	16641-16644	NN	denotes	10D
T8766	16644-16645	:	denotes	;
T8767	16646-16649	NN	denotes	SWR
T8769	16649-16650	HYPH	denotes	/
T8768	16650-16651	NN	denotes	J
T8771	16652-16655	NN	denotes	16L
T8772	16655-16657	,	denotes	,
T8770	16657-16660	NN	denotes	16D
T8773	16660-16661	:	denotes	;
T8774	16662-16666	NN	denotes	BALB
T8776	16666-16667	HYPH	denotes	/
T8775	16667-16671	NN	denotes	cByJ
T8778	16672-16675	NN	denotes	15L
T8779	16675-16677	,	denotes	,
T8777	16677-16680	NN	denotes	16D
T8780	16680-16681	:	denotes	;
T8781	16682-16687	CD	denotes	129B6
T8783	16688-16691	NN	denotes	10L
T8784	16691-16693	,	denotes	,
T8782	16693-16696	NN	denotes	12D
T8785	16696-16697	:	denotes	;
T8786	16698-16701	NN	denotes	CBA
T8788	16701-16702	HYPH	denotes	/
T8787	16702-16705	NN	denotes	CaJ
T8789	16706-16709	NN	denotes	22L
T8790	16709-16711	,	denotes	,
T8751	16711-16714	NN	denotes	16D
T8791	16714-16715	.	denotes	.
T2575	16717-16722	NN	denotes	Blood
T2576	16723-16731	NN	denotes	pressure
T2578	16732-16736	VBZ	denotes	does
T2579	16737-16740	RB	denotes	not
T2577	16741-16750	VB	denotes	correlate
T2580	16751-16755	IN	denotes	with
T2581	16756-16759	NN	denotes	IOP
T2582	16759-16891	sentence	denotes	An initial study of the relationship between blood pressure and IOP in mice did not detect a good correlation (R2 = 0.1, Figure 7).
T2583	16760-16762	DT	denotes	An
T2585	16763-16770	JJ	denotes	initial
T2584	16771-16776	NN	denotes	study
T2587	16777-16779	IN	denotes	of
T2588	16780-16783	DT	denotes	the
T2589	16784-16796	NN	denotes	relationship
T2590	16797-16804	IN	denotes	between
T2591	16805-16810	NN	denotes	blood
T2592	16811-16819	NN	denotes	pressure
T2593	16820-16823	CC	denotes	and
T2594	16824-16827	NN	denotes	IOP
T2595	16828-16830	IN	denotes	in
T2596	16831-16835	NNS	denotes	mice
T2597	16836-16839	VBD	denotes	did
T2598	16840-16843	RB	denotes	not
T2586	16844-16850	VB	denotes	detect
T2599	16851-16852	DT	denotes	a
T2601	16853-16857	JJ	denotes	good
T2600	16858-16869	NN	denotes	correlation
T2602	16870-16871	-LRB-	denotes	(
T2604	16871-16873	NN	denotes	R2
T2606	16874-16875	SYM	denotes	=
T2605	16876-16879	CD	denotes	0.1
T2607	16879-16881	,	denotes	,
T2603	16881-16887	NN	denotes	Figure
T2608	16888-16889	CD	denotes	7
T2609	16889-16890	-RRB-	denotes	)
T2610	16890-16891	.	denotes	.
T8800	16902-16904	DT	denotes	No
T8801	16905-16916	NN	denotes	correlation
T8802	16917-16924	IN	denotes	between
T8803	16925-16930	NN	denotes	blood
T8804	16931-16939	NN	denotes	pressure
T8805	16940-16943	CC	denotes	and
T8806	16944-16947	NN	denotes	IOP
T8807	16947-16948	.	denotes	.
T8808	16948-17086	sentence	denotes	There is no strong correlation between the average systolic blood pressure of each strain and the average IOP of that strain (R2 = 0.1).
T8809	16950-16955	EX	denotes	There
T8810	16956-16958	VBZ	denotes	is
T8811	16959-16961	DT	denotes	no
T8813	16962-16968	JJ	denotes	strong
T8812	16969-16980	NN	denotes	correlation
T8814	16981-16988	IN	denotes	between
T8815	16989-16992	DT	denotes	the
T8817	16993-17000	JJ	denotes	average
T8818	17001-17009	JJ	denotes	systolic
T8819	17010-17015	NN	denotes	blood
T8816	17016-17024	NN	denotes	pressure
T8820	17025-17027	IN	denotes	of
T8821	17028-17032	DT	denotes	each
T8822	17033-17039	NN	denotes	strain
T8823	17040-17043	CC	denotes	and
T8824	17044-17047	DT	denotes	the
T8826	17048-17055	JJ	denotes	average
T8825	17056-17059	NN	denotes	IOP
T8827	17060-17062	IN	denotes	of
T8828	17063-17067	DT	denotes	that
T8829	17068-17074	NN	denotes	strain
T8830	17075-17076	-LRB-	denotes	(
T8832	17076-17078	NN	denotes	R2
T8833	17079-17080	SYM	denotes	=
T8831	17081-17084	CD	denotes	0.1
T8834	17084-17085	-RRB-	denotes	)
T8835	17085-17086	.	denotes	.
T8836	17086-17221	sentence	denotes	All mice were female and 2 to 4 months old, with the exception that the female CBA/CaJ used for IOP assessment were 6 to 7 months old.
T8837	17087-17090	DT	denotes	All
T8838	17091-17095	NNS	denotes	mice
T8839	17096-17100	VBD	denotes	were
T8840	17101-17107	JJ	denotes	female
T8841	17108-17111	CC	denotes	and
T8842	17112-17113	CD	denotes	2
T8844	17114-17116	IN	denotes	to
T8843	17117-17118	CD	denotes	4
T8845	17119-17125	NNS	denotes	months
T8846	17126-17129	JJ	denotes	old
T8847	17129-17131	,	denotes	,
T8848	17131-17135	IN	denotes	with
T8849	17136-17139	DT	denotes	the
T8850	17140-17149	NN	denotes	exception
T8851	17150-17154	IN	denotes	that
T8853	17155-17158	DT	denotes	the
T8855	17159-17165	JJ	denotes	female
T8856	17166-17169	NN	denotes	CBA
T8857	17169-17170	HYPH	denotes	/
T8854	17170-17173	NN	denotes	CaJ
T8858	17174-17178	VBN	denotes	used
T8859	17179-17182	IN	denotes	for
T8860	17183-17186	NN	denotes	IOP
T8861	17187-17197	NN	denotes	assessment
T8852	17198-17202	VBD	denotes	were
T8862	17203-17204	CD	denotes	6
T8864	17205-17207	IN	denotes	to
T8863	17208-17209	CD	denotes	7
T8865	17210-17216	NNS	denotes	months
T8866	17217-17220	JJ	denotes	old
T8867	17220-17221	.	denotes	.
T8868	17221-17335	sentence	denotes	If the CBA/CaJ mice are excluded, R2 drops to 0.01 of ARK/J, C57BL/6J and SJL/J, strain ARK/J had the lowest IOP.
T8869	17222-17224	IN	denotes	If
T8871	17225-17228	DT	denotes	the
T8873	17229-17232	NN	denotes	CBA
T8875	17232-17233	HYPH	denotes	/
T8874	17233-17236	NN	denotes	CaJ
T8872	17237-17241	NNS	denotes	mice
T8876	17242-17245	VBP	denotes	are
T8870	17246-17254	VBN	denotes	excluded
T8878	17254-17256	,	denotes	,
T8879	17256-17258	NN	denotes	R2
T8877	17259-17264	VBZ	denotes	drops
T8881	17265-17267	IN	denotes	to
T8882	17268-17272	CD	denotes	0.01
T8883	17273-17275	IN	denotes	of
T8884	17276-17279	NN	denotes	ARK
T8886	17279-17280	HYPH	denotes	/
T8885	17280-17281	NN	denotes	J
T8887	17281-17283	,	denotes	,
T8888	17283-17288	NN	denotes	C57BL
T8890	17288-17289	HYPH	denotes	/
T8889	17289-17291	NN	denotes	6J
T8891	17292-17295	CC	denotes	and
T8892	17296-17299	NN	denotes	SJL
T8894	17299-17300	HYPH	denotes	/
T8893	17300-17301	NN	denotes	J
T8895	17301-17303	,	denotes	,
T8896	17303-17309	NN	denotes	strain
T8898	17310-17313	NN	denotes	ARK
T8899	17313-17314	HYPH	denotes	/
T8897	17314-17315	NN	denotes	J
T8880	17316-17319	VBD	denotes	had
T8900	17320-17323	DT	denotes	the
T8902	17324-17330	JJS	denotes	lowest
T8901	17331-17334	NN	denotes	IOP
T8903	17334-17335	.	denotes	.
T2627	17337-17341	NN	denotes	Myoc
T2628	17342-17349	NNS	denotes	alleles
T2630	17350-17352	VBP	denotes	do
T2631	17353-17356	RB	denotes	not
T2629	17357-17366	VB	denotes	associate
T2632	17367-17371	IN	denotes	with
T2633	17372-17375	DT	denotes	the
T2634	17376-17385	NN	denotes	magnitude
T2635	17386-17388	IN	denotes	of
T2636	17389-17392	NN	denotes	IOP
T2637	17392-17452	sentence	denotes	Mutations in the myocilin gene (MYOC) cause human glaucoma.
T2638	17393-17402	NNS	denotes	Mutations
T2640	17403-17405	IN	denotes	in
T2641	17406-17409	DT	denotes	the
T2643	17410-17418	NN	denotes	myocilin
T2642	17419-17423	NN	denotes	gene
T2644	17424-17425	-LRB-	denotes	(
T2645	17425-17429	NN	denotes	MYOC
T2646	17429-17430	-RRB-	denotes	)
T2639	17431-17436	VBP	denotes	cause
T2647	17437-17442	JJ	denotes	human
T2648	17443-17451	NN	denotes	glaucoma
T2649	17451-17452	.	denotes	.
T2650	17452-17617	sentence	denotes	To determine if allelic variation in the mouse Myoc gene associated with IOP in mouse strains, we analyzed the gene in an assortment of strains with different IOPs.
T2651	17453-17455	TO	denotes	To
T2652	17456-17465	VB	denotes	determine
T2654	17466-17468	IN	denotes	if
T2656	17469-17476	JJ	denotes	allelic
T2657	17477-17486	NN	denotes	variation
T2658	17487-17489	IN	denotes	in
T2659	17490-17493	DT	denotes	the
T2661	17494-17499	NN	denotes	mouse
T2662	17500-17504	NN	denotes	Myoc
T2660	17505-17509	NN	denotes	gene
T2655	17510-17520	VBD	denotes	associated
T2663	17521-17525	IN	denotes	with
T2664	17526-17529	NN	denotes	IOP
T2665	17530-17532	IN	denotes	in
T2666	17533-17538	NN	denotes	mouse
T2667	17539-17546	NNS	denotes	strains
T2668	17546-17548	,	denotes	,
T2669	17548-17550	PRP	denotes	we
T2653	17551-17559	VBD	denotes	analyzed
T2670	17560-17563	DT	denotes	the
T2671	17564-17568	NN	denotes	gene
T2672	17569-17571	IN	denotes	in
T2673	17572-17574	DT	denotes	an
T2674	17575-17585	NN	denotes	assortment
T2675	17586-17588	IN	denotes	of
T2676	17589-17596	NNS	denotes	strains
T2677	17597-17601	IN	denotes	with
T2678	17602-17611	JJ	denotes	different
T2679	17612-17616	NNS	denotes	IOPs
T2680	17616-17617	.	denotes	.
T2681	17617-17646	sentence	denotes	Two alleles were identified.
T2682	17618-17621	CD	denotes	Two
T2683	17622-17629	NNS	denotes	alleles
T2685	17630-17634	VBD	denotes	were
T2684	17635-17645	VBN	denotes	identified
T2686	17645-17646	.	denotes	.
T2687	17646-17850	sentence	denotes	One of these alleles had a 12 nucleotide insertion in the promoter region (ccagagcagggt, between positions -340 and -341) compared to the previously published sequence and is called the insertion allele.
T2688	17647-17650	CD	denotes	One
T2690	17651-17653	IN	denotes	of
T2691	17654-17659	DT	denotes	these
T2692	17660-17667	NNS	denotes	alleles
T2689	17668-17671	VBD	denotes	had
T2693	17672-17673	DT	denotes	a
T2695	17674-17676	CD	denotes	12
T2696	17677-17687	NN	denotes	nucleotide
T2694	17688-17697	NN	denotes	insertion
T2697	17698-17700	IN	denotes	in
T2698	17701-17704	DT	denotes	the
T2700	17705-17713	NN	denotes	promoter
T2699	17714-17720	NN	denotes	region
T2701	17721-17722	-LRB-	denotes	(
T2702	17722-17734	NN	denotes	ccagagcagggt
T2703	17734-17736	,	denotes	,
T2704	17736-17743	IN	denotes	between
T2705	17744-17753	NNS	denotes	positions
T2707	17754-17755	SYM	denotes	-
T2706	17755-17758	CD	denotes	340
T2708	17759-17762	CC	denotes	and
T2709	17763-17764	SYM	denotes	-
T2710	17764-17767	CD	denotes	341
T2711	17767-17768	-RRB-	denotes	)
T2712	17769-17777	VBN	denotes	compared
T2713	17778-17780	IN	denotes	to
T2714	17781-17784	DT	denotes	the
T2716	17785-17795	RB	denotes	previously
T2717	17796-17805	VBN	denotes	published
T2715	17806-17814	NN	denotes	sequence
T2718	17815-17818	CC	denotes	and
T2719	17819-17821	VBZ	denotes	is
T2720	17822-17828	VBN	denotes	called
T2721	17829-17832	DT	denotes	the
T2723	17833-17842	NN	denotes	insertion
T2722	17843-17849	NN	denotes	allele
T2724	17849-17850	.	denotes	.
T2725	17850-17913	sentence	denotes	The other allele was identical to the published sequence [22].
T2726	17851-17854	DT	denotes	The
T2728	17855-17860	JJ	denotes	other
T2727	17861-17867	NN	denotes	allele
T2729	17868-17871	VBD	denotes	was
T2730	17872-17881	JJ	denotes	identical
T2731	17882-17884	IN	denotes	to
T2732	17885-17888	DT	denotes	the
T2734	17889-17898	JJ	denotes	published
T2733	17899-17907	NN	denotes	sequence
T2735	17908-17909	-LRB-	denotes	[
T2736	17909-17911	CD	denotes	22
T2737	17911-17912	-RRB-	denotes	]
T2738	17912-17913	.	denotes	.
T2739	17913-18075	sentence	denotes	The insertion allele also had a previously reported substitution (A to G, Thr164Ala) in exon 1 and several other single base changes in the promoter region [22].
T2740	17914-17917	DT	denotes	The
T2742	17918-17927	NN	denotes	insertion
T2741	17928-17934	NN	denotes	allele
T2744	17935-17939	RB	denotes	also
T2743	17940-17943	VBD	denotes	had
T2745	17944-17945	DT	denotes	a
T2747	17946-17956	RB	denotes	previously
T2748	17957-17965	VBN	denotes	reported
T2746	17966-17978	NN	denotes	substitution
T2749	17979-17980	-LRB-	denotes	(
T2750	17980-17981	NN	denotes	A
T2751	17982-17984	IN	denotes	to
T2752	17985-17986	NN	denotes	G
T2753	17986-17988	,	denotes	,
T2754	17988-17997	NN	denotes	Thr164Ala
T2755	17997-17998	-RRB-	denotes	)
T2756	17999-18001	IN	denotes	in
T2757	18002-18006	NN	denotes	exon
T2758	18007-18008	CD	denotes	1
T2759	18009-18012	CC	denotes	and
T2760	18013-18020	JJ	denotes	several
T2762	18021-18026	JJ	denotes	other
T2763	18027-18033	JJ	denotes	single
T2764	18034-18038	NN	denotes	base
T2761	18039-18046	NNS	denotes	changes
T2765	18047-18049	IN	denotes	in
T2766	18050-18053	DT	denotes	the
T2768	18054-18062	NN	denotes	promoter
T2767	18063-18069	NN	denotes	region
T2769	18070-18071	-LRB-	denotes	[
T2770	18071-18073	CD	denotes	22
T2771	18073-18074	-RRB-	denotes	]
T2772	18074-18075	.	denotes	.
T2773	18075-18203	sentence	denotes	The presence or absence of this allele does not associate with IOP as it is present in strains with a range of IOPs (Figure 8).
T2774	18076-18079	DT	denotes	The
T2775	18080-18088	NN	denotes	presence
T2777	18089-18091	CC	denotes	or
T2778	18092-18099	NN	denotes	absence
T2779	18100-18102	IN	denotes	of
T2780	18103-18107	DT	denotes	this
T2781	18108-18114	NN	denotes	allele
T2782	18115-18119	VBZ	denotes	does
T2783	18120-18123	RB	denotes	not
T2776	18124-18133	VB	denotes	associate
T2784	18134-18138	IN	denotes	with
T2785	18139-18142	NN	denotes	IOP
T2786	18143-18145	IN	denotes	as
T2788	18146-18148	PRP	denotes	it
T2787	18149-18151	VBZ	denotes	is
T2789	18152-18159	JJ	denotes	present
T2790	18160-18162	IN	denotes	in
T2791	18163-18170	NNS	denotes	strains
T2792	18171-18175	IN	denotes	with
T2793	18176-18177	DT	denotes	a
T2794	18178-18183	NN	denotes	range
T2795	18184-18186	IN	denotes	of
T2796	18187-18191	NNS	denotes	IOPs
T2797	18192-18193	-LRB-	denotes	(
T2798	18193-18199	NN	denotes	Figure
T2799	18200-18201	CD	denotes	8
T2800	18201-18202	-RRB-	denotes	)
T2801	18202-18203	.	denotes	.
T8918	18214-18218	NN	denotes	Myoc
T8919	18219-18226	NNS	denotes	alleles
T8921	18227-18229	VBP	denotes	do
T8922	18230-18233	RB	denotes	not
T8920	18234-18243	VB	denotes	associate
T8923	18244-18248	IN	denotes	with
T8924	18249-18252	NN	denotes	IOP
T8925	18252-18253	.	denotes	.
T8926	18253-18331	sentence	denotes	Sequencing identified two alleles of Myoc in these mouse strains (see text).
T8927	18255-18265	NN	denotes	Sequencing
T8928	18266-18276	VBD	denotes	identified
T8929	18277-18280	CD	denotes	two
T8930	18281-18288	NNS	denotes	alleles
T8931	18289-18291	IN	denotes	of
T8932	18292-18296	NN	denotes	Myoc
T8933	18297-18299	IN	denotes	in
T8934	18300-18305	DT	denotes	these
T8936	18306-18311	NN	denotes	mouse
T8935	18312-18319	NNS	denotes	strains
T8937	18320-18321	-LRB-	denotes	(
T8938	18321-18324	VB	denotes	see
T8939	18325-18329	NN	denotes	text
T8940	18329-18330	-RRB-	denotes	)
T8941	18330-18331	.	denotes	.
T8942	18331-18520	sentence	denotes	Mouse strains homozygous for an allele having a 12 bp insertion in the promoter region are shown as open bars and strains homozygous for the allele without this insertion have filled bars.
T8943	18332-18337	NN	denotes	Mouse
T8944	18338-18345	NNS	denotes	strains
T8946	18346-18356	JJ	denotes	homozygous
T8947	18357-18360	IN	denotes	for
T8948	18361-18363	DT	denotes	an
T8949	18364-18370	NN	denotes	allele
T8950	18371-18377	VBG	denotes	having
T8951	18378-18379	DT	denotes	a
T8953	18380-18382	CD	denotes	12
T8954	18383-18385	NN	denotes	bp
T8952	18386-18395	NN	denotes	insertion
T8955	18396-18398	IN	denotes	in
T8956	18399-18402	DT	denotes	the
T8958	18403-18411	NN	denotes	promoter
T8957	18412-18418	NN	denotes	region
T8959	18419-18422	VBP	denotes	are
T8945	18423-18428	VBN	denotes	shown
T8960	18429-18431	IN	denotes	as
T8961	18432-18436	JJ	denotes	open
T8962	18437-18441	NNS	denotes	bars
T8963	18442-18445	CC	denotes	and
T8964	18446-18453	NNS	denotes	strains
T8966	18454-18464	JJ	denotes	homozygous
T8967	18465-18468	IN	denotes	for
T8968	18469-18472	DT	denotes	the
T8969	18473-18479	NN	denotes	allele
T8970	18480-18487	IN	denotes	without
T8971	18488-18492	DT	denotes	this
T8972	18493-18502	NN	denotes	insertion
T8965	18503-18507	VBP	denotes	have
T8973	18508-18514	JJ	denotes	filled
T8974	18515-18519	NNS	denotes	bars
T8975	18519-18520	.	denotes	.
T8976	18520-18566	sentence	denotes	The IOP data is the same as that in Figure 1.
T8977	18521-18524	DT	denotes	The
T8979	18525-18528	NNP	denotes	IOP
T8978	18529-18533	NN	denotes	data
T8980	18534-18536	VBZ	denotes	is
T8981	18537-18540	DT	denotes	the
T8982	18541-18545	JJ	denotes	same
T8983	18546-18548	IN	denotes	as
T8984	18549-18553	DT	denotes	that
T8985	18554-18556	IN	denotes	in
T8986	18557-18563	NN	denotes	Figure
T8987	18564-18565	CD	denotes	1
T8988	18565-18566	.	denotes	.
T2893	18568-18575	JJ	denotes	Genetic
T2894	18576-18587	NNS	denotes	alterations
T2895	18588-18591	CC	denotes	and
T2896	18592-18595	NN	denotes	IOP
T2897	18595-18609	sentence	denotes	Y Chromosome
T2898	18597-18598	NN	denotes	Y
T2899	18599-18609	NN	denotes	Chromosome
T2900	18609-18709	sentence	denotes	The Y chromosome has been implicated in strain specific blood pressure differences in rats [23,24].
T2901	18610-18613	DT	denotes	The
T2903	18614-18615	NN	denotes	Y
T2902	18616-18626	NN	denotes	chromosome
T2905	18627-18630	VBZ	denotes	has
T2906	18631-18635	VBN	denotes	been
T2904	18636-18646	VBN	denotes	implicated
T2907	18647-18649	IN	denotes	in
T2908	18650-18656	NN	denotes	strain
T2909	18657-18665	JJ	denotes	specific
T2911	18666-18671	NN	denotes	blood
T2912	18672-18680	NN	denotes	pressure
T2910	18681-18692	NNS	denotes	differences
T2913	18693-18695	IN	denotes	in
T2914	18696-18700	NNS	denotes	rats
T2915	18701-18702	-LRB-	denotes	[
T2917	18702-18704	CD	denotes	23
T2918	18704-18705	,	denotes	,
T2916	18705-18707	CD	denotes	24
T2919	18707-18708	-RRB-	denotes	]
T2920	18708-18709	.	denotes	.
T2921	18709-18930	sentence	denotes	To test if the Y chromosome of strain 129/Ola alters IOP in relation to that of strain B6, we compared the IOPs of pure B6 males and consomic B6 males that had the 129P2/Ola Y chromosome (backcrossed for 11 generations).
T2922	18710-18712	TO	denotes	To
T2923	18713-18717	VB	denotes	test
T2925	18718-18720	IN	denotes	if
T2927	18721-18724	DT	denotes	the
T2929	18725-18726	NN	denotes	Y
T2928	18727-18737	NN	denotes	chromosome
T2930	18738-18740	IN	denotes	of
T2931	18741-18747	NN	denotes	strain
T2933	18748-18751	NN	denotes	129
T2934	18751-18752	HYPH	denotes	/
T2932	18752-18755	NN	denotes	Ola
T2926	18756-18762	VBZ	denotes	alters
T2935	18763-18766	NN	denotes	IOP
T2936	18767-18769	IN	denotes	in
T2937	18770-18778	NN	denotes	relation
T2938	18779-18781	IN	denotes	to
T2939	18782-18786	DT	denotes	that
T2940	18787-18789	IN	denotes	of
T2941	18790-18796	NN	denotes	strain
T2942	18797-18799	NN	denotes	B6
T2943	18799-18801	,	denotes	,
T2944	18801-18803	PRP	denotes	we
T2924	18804-18812	VBD	denotes	compared
T2945	18813-18816	DT	denotes	the
T2946	18817-18821	NNS	denotes	IOPs
T2947	18822-18824	IN	denotes	of
T2948	18825-18829	JJ	denotes	pure
T2950	18830-18832	NN	denotes	B6
T2949	18833-18838	NNS	denotes	males
T2951	18839-18842	CC	denotes	and
T2952	18843-18851	JJ	denotes	consomic
T2954	18852-18854	NN	denotes	B6
T2953	18855-18860	NNS	denotes	males
T2955	18861-18865	WDT	denotes	that
T2956	18866-18869	VBD	denotes	had
T2957	18870-18873	DT	denotes	the
T2959	18874-18879	NN	denotes	129P2
T2961	18879-18880	HYPH	denotes	/
T2960	18880-18883	NN	denotes	Ola
T2962	18884-18885	NN	denotes	Y
T2958	18886-18896	NN	denotes	chromosome
T2963	18897-18898	-LRB-	denotes	(
T2964	18898-18909	VBN	denotes	backcrossed
T2965	18910-18913	IN	denotes	for
T2966	18914-18916	CD	denotes	11
T2967	18917-18928	NNS	denotes	generations
T2968	18928-18929	-RRB-	denotes	)
T2969	18929-18930	.	denotes	.
T2970	18930-19016	sentence	denotes	No differences in IOP were detected between these groups of mice (Figure 9, P = 0.1).
T2971	18931-18933	DT	denotes	No
T2972	18934-18945	NNS	denotes	differences
T2974	18946-18948	IN	denotes	in
T2975	18949-18952	NN	denotes	IOP
T2976	18953-18957	VBD	denotes	were
T2973	18958-18966	VBN	denotes	detected
T2977	18967-18974	IN	denotes	between
T2978	18975-18980	DT	denotes	these
T2979	18981-18987	NNS	denotes	groups
T2980	18988-18990	IN	denotes	of
T2981	18991-18995	NNS	denotes	mice
T2982	18996-18997	-LRB-	denotes	(
T2983	18997-19003	NN	denotes	Figure
T2984	19004-19005	CD	denotes	9
T2985	19005-19007	,	denotes	,
T2986	19007-19008	NN	denotes	P
T2988	19009-19010	SYM	denotes	=
T2987	19011-19014	CD	denotes	0.1
T2989	19014-19015	-RRB-	denotes	)
T2990	19015-19016	.	denotes	.
T2991	19016-19017	sentence	denotes
T9016	19027-19034	NNS	denotes	Effects
T9017	19035-19037	IN	denotes	of
T9018	19038-19045	JJ	denotes	genetic
T9019	19046-19057	NNS	denotes	alterations
T9020	19057-19058	.	denotes	.
T9021	19058-19084	sentence	denotes	Mean IOP ± SEM is shown.
T9022	19060-19064	NN	denotes	Mean
T9023	19065-19068	NN	denotes	IOP
T9025	19069-19070	SYM	denotes	±
T9026	19071-19074	NN	denotes	SEM
T9027	19075-19077	VBZ	denotes	is
T9024	19078-19083	VBN	denotes	shown
T9028	19083-19084	.	denotes	.
T9029	19084-19223	sentence	denotes	There is no difference in IOP between 3 to 4 month old males with either the 129P2/Ola (n = 18) or C57BL/6J (n = 20) Y chromosome (Y Chr).
T9030	19085-19090	EX	denotes	There
T9031	19091-19093	VBZ	denotes	is
T9032	19094-19096	DT	denotes	no
T9033	19097-19107	NN	denotes	difference
T9034	19108-19110	IN	denotes	in
T9035	19111-19114	NN	denotes	IOP
T9036	19115-19122	IN	denotes	between
T9037	19123-19124	CD	denotes	3
T9039	19125-19127	IN	denotes	to
T9038	19128-19129	CD	denotes	4
T9040	19130-19135	NN	denotes	month
T9041	19136-19139	JJ	denotes	old
T9042	19140-19145	NNS	denotes	males
T9043	19146-19150	IN	denotes	with
T9044	19151-19157	CC	denotes	either
T9046	19158-19161	DT	denotes	the
T9047	19162-19167	NN	denotes	129P2
T9048	19167-19168	HYPH	denotes	/
T9045	19168-19171	NN	denotes	Ola
T9049	19172-19173	-LRB-	denotes	(
T9051	19173-19174	NN	denotes	n
T9052	19175-19176	SYM	denotes	=
T9050	19177-19179	CD	denotes	18
T9053	19179-19180	-RRB-	denotes	)
T9054	19181-19183	CC	denotes	or
T9055	19184-19189	NN	denotes	C57BL
T9057	19189-19190	HYPH	denotes	/
T9056	19190-19192	NN	denotes	6J
T9058	19193-19194	-LRB-	denotes	(
T9060	19194-19195	NN	denotes	n
T9061	19196-19197	SYM	denotes	=
T9059	19198-19200	CD	denotes	20
T9062	19200-19201	-RRB-	denotes	)
T9063	19202-19203	NN	denotes	Y
T9064	19204-19214	NN	denotes	chromosome
T9065	19215-19216	-LRB-	denotes	(
T9066	19216-19217	NN	denotes	Y
T9067	19218-19221	NN	denotes	Chr
T9068	19221-19222	-RRB-	denotes	)
T9069	19222-19223	.	denotes	.
T9070	19223-19297	sentence	denotes	The 129 Y Chr had been backcrossed to strain C57BL/6J for 11 generations.
T9071	19224-19227	DT	denotes	The
T9073	19228-19231	CD	denotes	129
T9074	19232-19233	NN	denotes	Y
T9072	19234-19237	NN	denotes	Chr
T9076	19238-19241	VBD	denotes	had
T9077	19242-19246	VBN	denotes	been
T9075	19247-19258	VBN	denotes	backcrossed
T9078	19259-19261	IN	denotes	to
T9079	19262-19268	NN	denotes	strain
T9081	19269-19274	NN	denotes	C57BL
T9082	19274-19275	HYPH	denotes	/
T9080	19275-19277	NN	denotes	6J
T9083	19278-19281	IN	denotes	for
T9084	19282-19284	CD	denotes	11
T9085	19285-19296	NNS	denotes	generations
T9086	19296-19297	.	denotes	.
T9087	19297-19457	sentence	denotes	Similarly, 6 to 9 month old males and females that are homozygous for normal (+) or mutant (n) alleles of Car2 have similar IOPs (n = 18 and 14, respectively).
T9088	19298-19307	RB	denotes	Similarly
T9090	19307-19309	,	denotes	,
T9091	19309-19310	CD	denotes	6
T9093	19311-19313	IN	denotes	to
T9092	19314-19315	CD	denotes	9
T9094	19316-19321	NN	denotes	month
T9095	19322-19325	JJ	denotes	old
T9096	19326-19331	NNS	denotes	males
T9097	19332-19335	CC	denotes	and
T9098	19336-19343	NNS	denotes	females
T9099	19344-19348	WDT	denotes	that
T9100	19349-19352	VBP	denotes	are
T9101	19353-19363	JJ	denotes	homozygous
T9102	19364-19367	IN	denotes	for
T9103	19368-19374	JJ	denotes	normal
T9105	19375-19376	-LRB-	denotes	(
T9106	19376-19377	SYM	denotes	+
T9107	19377-19378	-RRB-	denotes	)
T9108	19379-19381	CC	denotes	or
T9109	19382-19388	NN	denotes	mutant
T9110	19389-19390	-LRB-	denotes	(
T9111	19390-19391	NN	denotes	n
T9112	19391-19392	-RRB-	denotes	)
T9104	19393-19400	NNS	denotes	alleles
T9113	19401-19403	IN	denotes	of
T9114	19404-19408	NN	denotes	Car2
T9089	19409-19413	VBP	denotes	have
T9115	19414-19421	JJ	denotes	similar
T9116	19422-19426	NNS	denotes	IOPs
T9117	19427-19428	-LRB-	denotes	(
T9119	19428-19429	NN	denotes	n
T9120	19430-19431	SYM	denotes	=
T9118	19432-19434	CD	denotes	18
T9121	19435-19438	CC	denotes	and
T9122	19439-19441	CD	denotes	14
T9123	19441-19443	,	denotes	,
T9124	19443-19455	RB	denotes	respectively
T9125	19455-19456	-RRB-	denotes	)
T9126	19456-19457	.	denotes	.
T9127	19457-19639	sentence	denotes	However, 4 months old males homozygous for the Lepr diabetes and obesity causing mutation (db) had significantly higher IOPs than their heterozygous age and sex matched littermates.
T9128	19458-19465	RB	denotes	However
T9130	19465-19467	,	denotes	,
T9131	19467-19468	CD	denotes	4
T9132	19469-19475	NNS	denotes	months
T9133	19476-19479	JJ	denotes	old
T9134	19480-19485	NNS	denotes	males
T9135	19486-19496	JJ	denotes	homozygous
T9136	19497-19500	IN	denotes	for
T9137	19501-19504	DT	denotes	the
T9139	19505-19509	NN	denotes	Lepr
T9140	19510-19518	NN	denotes	diabetes
T9141	19519-19522	CC	denotes	and
T9142	19523-19530	NN	denotes	obesity
T9143	19531-19538	VBG	denotes	causing
T9138	19539-19547	NN	denotes	mutation
T9144	19548-19549	-LRB-	denotes	(
T9145	19549-19551	NN	denotes	db
T9146	19551-19552	-RRB-	denotes	)
T9129	19553-19556	VBD	denotes	had
T9147	19557-19570	RB	denotes	significantly
T9148	19571-19577	JJR	denotes	higher
T9149	19578-19582	NNS	denotes	IOPs
T9150	19583-19587	IN	denotes	than
T9151	19588-19593	PRP$	denotes	their
T9153	19594-19606	JJ	denotes	heterozygous
T9154	19607-19610	NN	denotes	age
T9156	19611-19614	CC	denotes	and
T9157	19615-19618	NN	denotes	sex
T9155	19619-19626	VBN	denotes	matched
T9152	19627-19638	NNS	denotes	littermates
T9158	19638-19639	.	denotes	.
T9159	19639-19770	sentence	denotes	The average body weight of the homozygotes and heterozygotes was 59 g (range 50 to 64 g) and 35 g (range 28 to 41 g) respectively.
T9160	19640-19643	DT	denotes	The
T9162	19644-19651	JJ	denotes	average
T9163	19652-19656	NN	denotes	body
T9161	19657-19663	NN	denotes	weight
T9165	19664-19666	IN	denotes	of
T9166	19667-19670	DT	denotes	the
T9167	19671-19682	NNS	denotes	homozygotes
T9168	19683-19686	CC	denotes	and
T9169	19687-19700	NNS	denotes	heterozygotes
T9164	19701-19704	VBD	denotes	was
T9170	19705-19707	CD	denotes	59
T9171	19708-19709	NNS	denotes	g
T9172	19710-19711	-LRB-	denotes	(
T9173	19711-19716	NN	denotes	range
T9174	19717-19719	CD	denotes	50
T9176	19720-19722	IN	denotes	to
T9175	19723-19725	CD	denotes	64
T9177	19726-19727	NNS	denotes	g
T9178	19727-19728	-RRB-	denotes	)
T9179	19729-19732	CC	denotes	and
T9180	19733-19735	CD	denotes	35
T9181	19736-19737	NNS	denotes	g
T9182	19738-19739	-LRB-	denotes	(
T9183	19739-19744	NN	denotes	range
T9184	19745-19747	CD	denotes	28
T9186	19748-19750	IN	denotes	to
T9185	19751-19753	CD	denotes	41
T9187	19754-19755	NNS	denotes	g
T9188	19755-19756	-RRB-	denotes	)
T9189	19757-19769	RB	denotes	respectively
T9190	19769-19770	.	denotes	.
T9191	19770-19904	sentence	denotes	Blood sugar levels in db /db males of this age are almost always in the diabetic range whereas those of heterozygotes are not [[27]].
T9192	19771-19776	NN	denotes	Blood
T9193	19777-19782	NN	denotes	sugar
T9194	19783-19789	NNS	denotes	levels
T9196	19790-19792	IN	denotes	in
T9197	19793-19795	NN	denotes	db
T9199	19796-19797	HYPH	denotes	/
T9198	19797-19799	NN	denotes	db
T9200	19800-19805	NNS	denotes	males
T9201	19806-19808	IN	denotes	of
T9202	19809-19813	DT	denotes	this
T9203	19814-19817	NN	denotes	age
T9195	19818-19821	VBP	denotes	are
T9204	19822-19828	RB	denotes	almost
T9205	19829-19835	RB	denotes	always
T9206	19836-19838	IN	denotes	in
T9207	19839-19842	DT	denotes	the
T9209	19843-19851	JJ	denotes	diabetic
T9208	19852-19857	NN	denotes	range
T9210	19858-19865	IN	denotes	whereas
T9212	19866-19871	DT	denotes	those
T9213	19872-19874	IN	denotes	of
T9214	19875-19888	NNS	denotes	heterozygotes
T9211	19889-19892	VBP	denotes	are
T9215	19893-19896	RB	denotes	not
T9216	19897-19898	-LRB-	denotes	[
T9218	19898-19899	-LRB-	denotes	[
T9217	19899-19901	CD	denotes	27
T9219	19901-19902	-RRB-	denotes	]
T9220	19902-19903	-RRB-	denotes	]
T9221	19903-19904	.	denotes	.
T9222	19904-20110	sentence	denotes	This was recently confirmed in cohorts of approximately 25 males of each genotype (mean ± SD; db/db 422 ± 110 mg/dl ; db/+ 147 ± 19 mg/dl; Anthony Nicholson, The Jackson Laboratory, personal communication)
T9223	19905-19909	DT	denotes	This
T9225	19910-19913	VBD	denotes	was
T9226	19914-19922	RB	denotes	recently
T9224	19923-19932	VBN	denotes	confirmed
T9227	19933-19935	IN	denotes	in
T9228	19936-19943	NNS	denotes	cohorts
T9229	19944-19946	IN	denotes	of
T9230	19947-19960	RB	denotes	approximately
T9231	19961-19963	CD	denotes	25
T9232	19964-19969	NNS	denotes	males
T9233	19970-19972	IN	denotes	of
T9234	19973-19977	DT	denotes	each
T9235	19978-19986	NN	denotes	genotype
T9236	19987-19988	-LRB-	denotes	(
T9238	19988-19992	NN	denotes	mean
T9239	19993-19994	SYM	denotes	±
T9237	19995-19997	NN	denotes	SD
T9240	19997-19998	:	denotes	;
T9241	19999-20001	NN	denotes	db
T9243	20001-20002	HYPH	denotes	/
T9242	20002-20004	NN	denotes	db
T9245	20005-20008	CD	denotes	422
T9246	20009-20010	SYM	denotes	±
T9247	20011-20014	CD	denotes	110
T9248	20015-20017	NNS	denotes	mg
T9249	20017-20018	SYM	denotes	/
T9250	20018-20020	NN	denotes	dl
T9251	20021-20022	:	denotes	;
T9244	20023-20025	NN	denotes	db
T9252	20025-20026	HYPH	denotes	/
T9253	20026-20027	SYM	denotes	+
T9254	20028-20031	CD	denotes	147
T9255	20032-20033	SYM	denotes	±
T9256	20034-20036	CD	denotes	19
T9257	20037-20039	NNS	denotes	mg
T9258	20039-20040	SYM	denotes	/
T9259	20040-20042	NN	denotes	dl
T9260	20042-20043	:	denotes	;
T9261	20044-20051	NNP	denotes	Anthony
T9262	20052-20061	NNP	denotes	Nicholson
T9263	20061-20063	,	denotes	,
T9264	20063-20066	DT	denotes	The
T9265	20067-20074	NNP	denotes	Jackson
T9266	20075-20085	NNP	denotes	Laboratory
T9267	20085-20087	,	denotes	,
T9268	20087-20095	JJ	denotes	personal
T9269	20096-20109	NN	denotes	communication
T9270	20109-20110	-RRB-	denotes	)
T2993	20112-20113	NN	denotes	C
T2992	20112-20113	sentence	denotes	C
T2996	20113-20114	VBD	denotes	a
T2994	20113-20115	sentence	denotes	ar
T2995	20114-20115	VBN	denotes	r
T2998	20115-20116	NN	denotes	2
T2997	20115-20116	sentence	denotes	2
T2999	20116-20117	sentence	denotes
T3001	20117-20119	TO	denotes	To
T3000	20117-20313	sentence	denotes	To test if deficiency of carbonic anhydrase II leads to decreased IOP, we analyzed mice of a B6 background that were genetically similar but with normal or mutant alleles of the Car2 gene [25,26].
T3002	20120-20124	VB	denotes	test
T3004	20125-20127	IN	denotes	if
T3006	20128-20138	NN	denotes	deficiency
T3007	20139-20141	IN	denotes	of
T3008	20142-20150	JJ	denotes	carbonic
T3009	20151-20160	NN	denotes	anhydrase
T3010	20161-20163	CD	denotes	II
T3005	20164-20169	VBZ	denotes	leads
T3011	20170-20172	IN	denotes	to
T3012	20173-20182	VBN	denotes	decreased
T3013	20183-20186	NN	denotes	IOP
T3014	20186-20188	,	denotes	,
T3015	20188-20190	PRP	denotes	we
T3003	20191-20199	VBD	denotes	analyzed
T3016	20200-20204	NNS	denotes	mice
T3017	20205-20207	IN	denotes	of
T3018	20208-20209	DT	denotes	a
T3020	20210-20212	NN	denotes	B6
T3019	20213-20223	NN	denotes	background
T3021	20224-20228	WDT	denotes	that
T3022	20229-20233	VBD	denotes	were
T3023	20234-20245	RB	denotes	genetically
T3024	20246-20253	JJ	denotes	similar
T3025	20254-20257	CC	denotes	but
T3026	20258-20262	IN	denotes	with
T3027	20263-20269	JJ	denotes	normal
T3029	20270-20272	CC	denotes	or
T3030	20273-20279	JJ	denotes	mutant
T3028	20280-20287	NNS	denotes	alleles
T3031	20288-20290	IN	denotes	of
T3032	20291-20294	DT	denotes	the
T3034	20295-20299	NN	denotes	Car2
T3033	20300-20304	NN	denotes	gene
T3035	20305-20306	-LRB-	denotes	[
T3037	20306-20308	CD	denotes	25
T3038	20308-20309	,	denotes	,
T3036	20309-20311	CD	denotes	26
T3039	20311-20312	-RRB-	denotes	]
T3040	20312-20313	.	denotes	.
T3041	20313-20396	sentence	denotes	There was no difference in IOP between normal and mutant mice (Figure 9, P = 0.5).
T3042	20314-20319	EX	denotes	There
T3043	20320-20323	VBD	denotes	was
T3044	20324-20326	DT	denotes	no
T3045	20327-20337	NN	denotes	difference
T3046	20338-20340	IN	denotes	in
T3047	20341-20344	NN	denotes	IOP
T3048	20345-20352	IN	denotes	between
T3049	20353-20359	JJ	denotes	normal
T3051	20360-20363	CC	denotes	and
T3052	20364-20370	JJ	denotes	mutant
T3050	20371-20375	NNS	denotes	mice
T3053	20376-20377	-LRB-	denotes	(
T3054	20377-20383	NN	denotes	Figure
T3055	20384-20385	CD	denotes	9
T3056	20385-20387	,	denotes	,
T3057	20387-20388	NN	denotes	P
T3059	20389-20390	SYM	denotes	=
T3058	20391-20394	CD	denotes	0.5
T3060	20394-20395	-RRB-	denotes	)
T3061	20395-20396	.	denotes	.
T3062	20396-20402	sentence	denotes	Lepr
T3063	20398-20402	NNP	denotes	Lepr
T3064	20402-20714	sentence	denotes	To test if genetic perturbations that cause obesity and diabetes can alter IOP, we compared mice that were genetically similar but were either homozygous or heterozygous for a leptin receptor mutation (db) that results in obesity and diabetes before 4 months of age on the C57BLKS/J strain background used [27].
T3065	20403-20405	TO	denotes	To
T3066	20406-20410	VB	denotes	test
T3068	20411-20413	IN	denotes	if
T3070	20414-20421	JJ	denotes	genetic
T3071	20422-20435	NNS	denotes	perturbations
T3072	20436-20440	WDT	denotes	that
T3073	20441-20446	VBP	denotes	cause
T3074	20447-20454	NN	denotes	obesity
T3075	20455-20458	CC	denotes	and
T3076	20459-20467	NN	denotes	diabetes
T3077	20468-20471	MD	denotes	can
T3069	20472-20477	VB	denotes	alter
T3078	20478-20481	NN	denotes	IOP
T3079	20481-20483	,	denotes	,
T3080	20483-20485	PRP	denotes	we
T3067	20486-20494	VBD	denotes	compared
T3081	20495-20499	NNS	denotes	mice
T3082	20500-20504	WDT	denotes	that
T3083	20505-20509	VBD	denotes	were
T3084	20510-20521	RB	denotes	genetically
T3085	20522-20529	JJ	denotes	similar
T3086	20530-20533	CC	denotes	but
T3087	20534-20538	VBD	denotes	were
T3088	20539-20545	CC	denotes	either
T3089	20546-20556	JJ	denotes	homozygous
T3090	20557-20559	CC	denotes	or
T3091	20560-20572	JJ	denotes	heterozygous
T3092	20573-20576	IN	denotes	for
T3093	20577-20578	DT	denotes	a
T3095	20579-20585	NN	denotes	leptin
T3096	20586-20594	NN	denotes	receptor
T3094	20595-20603	NN	denotes	mutation
T3097	20604-20605	-LRB-	denotes	(
T3098	20605-20607	NN	denotes	db
T3099	20607-20608	-RRB-	denotes	)
T3100	20609-20613	WDT	denotes	that
T3101	20614-20621	VBZ	denotes	results
T3102	20622-20624	IN	denotes	in
T3103	20625-20632	NN	denotes	obesity
T3104	20633-20636	CC	denotes	and
T3105	20637-20645	NN	denotes	diabetes
T3106	20646-20652	IN	denotes	before
T3107	20653-20654	CD	denotes	4
T3108	20655-20661	NNS	denotes	months
T3109	20662-20664	IN	denotes	of
T3110	20665-20668	NN	denotes	age
T3111	20669-20671	IN	denotes	on
T3112	20672-20675	DT	denotes	the
T3114	20676-20683	NN	denotes	C57BLKS
T3116	20683-20684	HYPH	denotes	/
T3115	20684-20685	NN	denotes	J
T3117	20686-20692	NN	denotes	strain
T3113	20693-20703	NN	denotes	background
T3118	20704-20708	VBN	denotes	used
T3119	20709-20710	-LRB-	denotes	[
T3120	20710-20712	CD	denotes	27
T3121	20712-20713	-RRB-	denotes	]
T3122	20713-20714	.	denotes	.
T3123	20714-20903	sentence	denotes	IOP was modestly but significantly elevated in obese, diabetic homozygous mutants (14.7 ± 0.3 mmHg) compared to non-obese, non-diabetic heterozygotes (13.4 ± 0.4 mmHg, P < 0.01, Figure 9).
T3124	20715-20718	NN	denotes	IOP
T3125	20719-20722	VBD	denotes	was
T3126	20723-20731	RB	denotes	modestly
T3127	20732-20735	CC	denotes	but
T3128	20736-20749	RB	denotes	significantly
T3129	20750-20758	JJ	denotes	elevated
T3130	20759-20761	IN	denotes	in
T3131	20762-20767	JJ	denotes	obese
T3133	20767-20769	,	denotes	,
T3134	20769-20777	JJ	denotes	diabetic
T3135	20778-20788	JJ	denotes	homozygous
T3132	20789-20796	NNS	denotes	mutants
T3136	20797-20798	-LRB-	denotes	(
T3138	20798-20802	CD	denotes	14.7
T3140	20803-20804	SYM	denotes	±
T3139	20805-20808	CD	denotes	0.3
T3137	20809-20813	NN	denotes	mmHg
T2891	20813-20814	-RRB-	denotes	)
T3141	20815-20823	VBN	denotes	compared
T3142	20824-20826	IN	denotes	to
T3143	20827-20836	JJ	denotes	non-obese
T3145	20836-20838	,	denotes	,
T3146	20838-20850	JJ	denotes	non-diabetic
T3144	20851-20864	NNS	denotes	heterozygotes
T3147	20865-20866	-LRB-	denotes	(
T3149	20866-20870	CD	denotes	13.4
T3151	20871-20872	SYM	denotes	±
T3150	20873-20876	CD	denotes	0.4
T3152	20877-20881	NN	denotes	mmHg
T3153	20881-20883	,	denotes	,
T3154	20883-20884	NN	denotes	P
T3156	20885-20886	SYM	denotes	<
T3155	20887-20891	CD	denotes	0.01
T3157	20891-20893	,	denotes	,
T3148	20893-20899	NN	denotes	Figure
T3158	20900-20901	CD	denotes	9
T3159	20901-20902	-RRB-	denotes	)
T3160	20902-20903	.	denotes	.
T3161	20903-20908	sentence	denotes	Tyr
T3162	20905-20908	NN	denotes	Tyr
T3163	20908-21003	sentence	denotes	To determine if albinism alters IOP, we analyzed B6 mice that were either pigmented or albino.
T3164	20909-20911	TO	denotes	To
T3165	20912-20921	VB	denotes	determine
T3167	20922-20924	IN	denotes	if
T3169	20925-20933	NN	denotes	albinism
T3168	20934-20940	VBZ	denotes	alters
T3170	20941-20944	NNP	denotes	IOP
T3171	20944-20946	,	denotes	,
T3172	20946-20948	PRP	denotes	we
T3166	20949-20957	VBD	denotes	analyzed
T3173	20958-20960	NN	denotes	B6
T3174	20961-20965	NNS	denotes	mice
T3175	20966-20970	WDT	denotes	that
T3176	20971-20975	VBD	denotes	were
T3177	20976-20982	CC	denotes	either
T3178	20983-20992	JJ	denotes	pigmented
T3179	20993-20995	CC	denotes	or
T3180	20996-21002	NN	denotes	albino
T3181	21002-21003	.	denotes	.
T3182	21003-21147	sentence	denotes	The albino mice were homozygous and coisogenic for a mutant allele of tyrosinase (Tyrc-2J) that arose on the otherwise pigmented B6 background.
T3183	21004-21007	DT	denotes	The
T3185	21008-21014	NN	denotes	albino
T3184	21015-21019	NNS	denotes	mice
T3186	21020-21024	VBD	denotes	were
T3187	21025-21035	JJ	denotes	homozygous
T3188	21036-21039	CC	denotes	and
T3189	21040-21050	JJ	denotes	coisogenic
T3190	21051-21054	IN	denotes	for
T3191	21055-21056	DT	denotes	a
T3193	21057-21063	JJ	denotes	mutant
T3192	21064-21070	NN	denotes	allele
T3194	21071-21073	IN	denotes	of
T3195	21074-21084	NN	denotes	tyrosinase
T3196	21085-21086	-LRB-	denotes	(
T3197	21086-21090	NN	denotes	Tyrc
T3199	21090-21091	HYPH	denotes	-
T3198	21091-21093	NN	denotes	2J
T3200	21093-21094	-RRB-	denotes	)
T2892	21095-21099	WDT	denotes	that
T3201	21100-21105	VBD	denotes	arose
T3202	21106-21108	IN	denotes	on
T3203	21109-21112	DT	denotes	the
T3205	21113-21122	RB	denotes	otherwise
T3206	21123-21132	JJ	denotes	pigmented
T3207	21133-21135	NN	denotes	B6
T3204	21136-21146	NN	denotes	background
T3208	21146-21147	.	denotes	.
T3209	21147-21306	sentence	denotes	In 2 month old mice, homozygosity for Tyrc-2J resulted in increased IOP (14.2 ± 0.4 mmHg) compared to wild type, pigmented mice (12.4 ± 0.3 mmHg, P < 0.0001).
T3210	21148-21150	IN	denotes	In
T3212	21151-21152	CD	denotes	2
T3213	21153-21158	NN	denotes	month
T3214	21159-21162	JJ	denotes	old
T3215	21163-21167	NNS	denotes	mice
T3216	21167-21169	,	denotes	,
T3217	21169-21181	NN	denotes	homozygosity
T3218	21182-21185	IN	denotes	for
T3219	21186-21190	NN	denotes	Tyrc
T3221	21190-21191	HYPH	denotes	-
T3220	21191-21193	NN	denotes	2J
T3211	21194-21202	VBD	denotes	resulted
T3222	21203-21205	IN	denotes	in
T3223	21206-21215	VBN	denotes	increased
T3224	21216-21219	NN	denotes	IOP
T3225	21220-21221	-LRB-	denotes	(
T3227	21221-21225	CD	denotes	14.2
T3229	21226-21227	SYM	denotes	±
T3228	21228-21231	CD	denotes	0.4
T3226	21232-21236	NN	denotes	mmHg
T3230	21236-21237	-RRB-	denotes	)
T3231	21238-21246	VBN	denotes	compared
T3232	21247-21249	IN	denotes	to
T3233	21250-21254	JJ	denotes	wild
T3234	21255-21259	NN	denotes	type
T3236	21259-21261	,	denotes	,
T3237	21261-21270	VBN	denotes	pigmented
T3235	21271-21275	NNS	denotes	mice
T3238	21276-21277	-LRB-	denotes	(
T3240	21277-21281	CD	denotes	12.4
T3242	21282-21283	SYM	denotes	±
T3241	21284-21287	CD	denotes	0.3
T3239	21288-21292	NN	denotes	mmHg
T3243	21292-21294	,	denotes	,
T3244	21294-21295	NN	denotes	P
T3246	21296-21297	SYM	denotes	<
T3245	21298-21304	CD	denotes	0.0001
T3247	21304-21305	-RRB-	denotes	)
T3248	21305-21306	.	denotes	.
T3249	21306-21426	sentence	denotes	The same was true for independent cohorts of mice of different ages that were analyzed at different times (Figure 10A).
T3250	21307-21310	DT	denotes	The
T3251	21311-21315	JJ	denotes	same
T3252	21316-21319	VBD	denotes	was
T3253	21320-21324	JJ	denotes	true
T3254	21325-21328	IN	denotes	for
T3255	21329-21340	JJ	denotes	independent
T3256	21341-21348	NNS	denotes	cohorts
T3257	21349-21351	IN	denotes	of
T3258	21352-21356	NNS	denotes	mice
T3259	21357-21359	IN	denotes	of
T3260	21360-21369	JJ	denotes	different
T3261	21370-21374	NNS	denotes	ages
T3262	21375-21379	WDT	denotes	that
T3264	21380-21384	VBD	denotes	were
T3263	21385-21393	VBN	denotes	analyzed
T3265	21394-21396	IN	denotes	at
T3266	21397-21406	JJ	denotes	different
T3267	21407-21412	NNS	denotes	times
T3268	21413-21414	-LRB-	denotes	(
T3270	21414-21420	NN	denotes	Figure
T3269	21421-21424	NN	denotes	10A
T3271	21424-21425	-RRB-	denotes	)
T3272	21425-21426	.	denotes	.
T3273	21426-21611	sentence	denotes	In contrast to pigmented B6 mice (Figure 6), the IOPs of the albino B6 mice were not increased at measurement during the dark compared to light period of the day (P = 0.6, Figure 10B).
T3274	21427-21429	IN	denotes	In
T3276	21430-21438	NN	denotes	contrast
T3277	21439-21441	IN	denotes	to
T3278	21442-21451	JJ	denotes	pigmented
T3280	21452-21454	NN	denotes	B6
T3279	21455-21459	NNS	denotes	mice
T3281	21460-21461	-LRB-	denotes	(
T3282	21461-21467	NN	denotes	Figure
T3283	21468-21469	CD	denotes	6
T3284	21469-21470	-RRB-	denotes	)
T3285	21470-21472	,	denotes	,
T3286	21472-21475	DT	denotes	the
T3287	21476-21480	NNS	denotes	IOPs
T3288	21481-21483	IN	denotes	of
T3289	21484-21487	DT	denotes	the
T3291	21488-21494	NN	denotes	albino
T3292	21495-21497	NN	denotes	B6
T3290	21498-21502	NNS	denotes	mice
T3275	21503-21507	VBD	denotes	were
T3293	21508-21511	RB	denotes	not
T3294	21512-21521	JJ	denotes	increased
T3295	21522-21524	IN	denotes	at
T3296	21525-21536	NN	denotes	measurement
T3297	21537-21543	IN	denotes	during
T3298	21544-21547	DT	denotes	the
T3299	21548-21552	NN	denotes	dark
T3300	21553-21561	VBN	denotes	compared
T3301	21562-21564	IN	denotes	to
T3302	21565-21570	JJ	denotes	light
T3303	21571-21577	NN	denotes	period
T3304	21578-21580	IN	denotes	of
T3305	21581-21584	DT	denotes	the
T3306	21585-21588	NN	denotes	day
T3307	21589-21590	-LRB-	denotes	(
T3309	21590-21591	NN	denotes	P
T3311	21592-21593	SYM	denotes	=
T3310	21594-21597	CD	denotes	0.6
T3312	21597-21599	,	denotes	,
T3313	21599-21605	NN	denotes	Figure
T3308	21606-21609	NN	denotes	10B
T3314	21609-21610	-RRB-	denotes	)
T3315	21610-21611	.	denotes	.
T9308	21623-21626	NN	denotes	Tyr
T9309	21627-21635	NN	denotes	mutation
T9310	21636-21643	VBZ	denotes	results
T9311	21644-21646	IN	denotes	in
T9312	21647-21656	VBN	denotes	increased
T9313	21657-21660	NN	denotes	IOP
T9314	21661-21664	CC	denotes	and
T9315	21665-21672	JJ	denotes	altered
T9317	21673-21680	JJ	denotes	diurnal
T9316	21681-21688	NNS	denotes	changes
T9318	21688-21691	sentence	denotes	A.
T9319	21689-21690	NN	denotes	A
T9320	21690-21691	.	denotes	.
T9321	21691-21850	sentence	denotes	Different cohorts of C57BL/6J mice that are homozygous for the spontaneous Tyrc-2J mutation have higher IOP than their normal counterparts at all tested ages.
T9322	21692-21701	JJ	denotes	Different
T9323	21702-21709	NNS	denotes	cohorts
T9325	21710-21712	IN	denotes	of
T9326	21713-21718	NN	denotes	C57BL
T9328	21718-21719	HYPH	denotes	/
T9327	21719-21721	NN	denotes	6J
T9329	21722-21726	NNS	denotes	mice
T9330	21727-21731	WDT	denotes	that
T9331	21732-21735	VBP	denotes	are
T9332	21736-21746	JJ	denotes	homozygous
T9333	21747-21750	IN	denotes	for
T9334	21751-21754	DT	denotes	the
T9336	21755-21766	JJ	denotes	spontaneous
T9337	21767-21771	NN	denotes	Tyrc
T9339	21771-21772	HYPH	denotes	-
T9338	21772-21774	NN	denotes	2J
T9335	21775-21783	NN	denotes	mutation
T9324	21784-21788	VBP	denotes	have
T9340	21789-21795	JJR	denotes	higher
T9341	21796-21799	NN	denotes	IOP
T9342	21800-21804	IN	denotes	than
T9343	21805-21810	PRP$	denotes	their
T9345	21811-21817	JJ	denotes	normal
T9344	21818-21830	NNS	denotes	counterparts
T9346	21831-21833	IN	denotes	at
T9347	21834-21837	DT	denotes	all
T9349	21838-21844	VBN	denotes	tested
T9348	21845-21849	NNS	denotes	ages
T9350	21849-21850	.	denotes	.
T9351	21850-21896	sentence	denotes	All groups consisted of male and female mice.
T9352	21851-21854	DT	denotes	All
T9353	21855-21861	NNS	denotes	groups
T9354	21862-21871	VBD	denotes	consisted
T9355	21872-21874	IN	denotes	of
T9356	21875-21879	JJ	denotes	male
T9358	21880-21883	CC	denotes	and
T9359	21884-21890	JJ	denotes	female
T9357	21891-21895	NNS	denotes	mice
T9360	21895-21896	.	denotes	.
T9361	21896-21899	sentence	denotes	B.
T9362	21897-21898	NN	denotes	B
T9363	21898-21899	.	denotes	.
T9364	21899-21978	sentence	denotes	IOP is not increased during the dark period of the day in Tyrc-2J homozygotes.
T9365	21900-21903	NN	denotes	IOP
T9367	21904-21906	VBZ	denotes	is
T9368	21907-21910	RB	denotes	not
T9366	21911-21920	VBN	denotes	increased
T9369	21921-21927	IN	denotes	during
T9370	21928-21931	DT	denotes	the
T9372	21932-21936	JJ	denotes	dark
T9371	21937-21943	NN	denotes	period
T9373	21944-21946	IN	denotes	of
T9374	21947-21950	DT	denotes	the
T9375	21951-21954	NN	denotes	day
T9376	21955-21957	IN	denotes	in
T9377	21958-21962	NN	denotes	Tyrc
T9379	21962-21963	HYPH	denotes	-
T9378	21963-21965	NN	denotes	2J
T9380	21966-21977	NNS	denotes	homozygotes
T9381	21977-21978	.	denotes	.
T9382	21978-22135	sentence	denotes	The number of mice analyzed during the light period were: 2 month, 28 +/+, 29 c-2J/c-2J, 4 month, 20 +/+ and 20 c-2J/c-2J, 8 month, 15 +/+ and 15 c-2J/c-2J.
T9383	21979-21982	DT	denotes	The
T9384	21983-21989	NN	denotes	number
T9386	21990-21992	IN	denotes	of
T9387	21993-21997	NNS	denotes	mice
T9388	21998-22006	VBN	denotes	analyzed
T9389	22007-22013	IN	denotes	during
T9390	22014-22017	DT	denotes	the
T9392	22018-22023	JJ	denotes	light
T9391	22024-22030	NN	denotes	period
T9385	22031-22035	VBD	denotes	were
T9393	22035-22037	:	denotes	:
T9394	22037-22038	CD	denotes	2
T9395	22039-22044	NN	denotes	month
T9396	22044-22046	,	denotes	,
T9397	22046-22048	CD	denotes	28
T9398	22049-22050	SYM	denotes	+
T9399	22050-22051	HYPH	denotes	/
T9400	22051-22052	SYM	denotes	+
T9401	22052-22054	,	denotes	,
T9402	22054-22056	CD	denotes	29
T9403	22057-22058	NN	denotes	c
T9404	22058-22059	HYPH	denotes	-
T9405	22059-22061	NN	denotes	2J
T9407	22061-22062	HYPH	denotes	/
T9406	22062-22063	NN	denotes	c
T9408	22063-22064	HYPH	denotes	-
T9409	22064-22066	NN	denotes	2J
T9410	22066-22068	,	denotes	,
T9411	22068-22069	CD	denotes	4
T9412	22070-22075	NN	denotes	month
T9413	22075-22077	,	denotes	,
T9414	22077-22079	CD	denotes	20
T9415	22080-22081	SYM	denotes	+
T9416	22081-22082	HYPH	denotes	/
T9417	22082-22083	SYM	denotes	+
T9418	22084-22087	CC	denotes	and
T9419	22088-22090	CD	denotes	20
T9420	22091-22092	NN	denotes	c
T9421	22092-22093	HYPH	denotes	-
T9422	22093-22095	NN	denotes	2J
T9424	22095-22096	HYPH	denotes	/
T9423	22096-22097	NN	denotes	c
T9425	22097-22098	HYPH	denotes	-
T9426	22098-22100	NN	denotes	2J
T9427	22100-22102	,	denotes	,
T9428	22102-22103	CD	denotes	8
T9429	22104-22109	NN	denotes	month
T9430	22109-22111	,	denotes	,
T9431	22111-22113	CD	denotes	15
T9432	22114-22115	SYM	denotes	+
T9433	22115-22116	HYPH	denotes	/
T9434	22116-22117	SYM	denotes	+
T9435	22118-22121	CC	denotes	and
T9436	22122-22124	CD	denotes	15
T9437	22125-22126	NN	denotes	c
T9438	22126-22127	HYPH	denotes	-
T9439	22127-22129	NN	denotes	2J
T9441	22129-22130	HYPH	denotes	/
T9440	22130-22131	NN	denotes	c
T9442	22131-22132	HYPH	denotes	-
T9443	22132-22134	NN	denotes	2J
T9444	22134-22135	.	denotes	.
T9445	22135-22228	sentence	denotes	Fourteen mice of each genotype were successfully analyzed during the dark period of the day.
T9446	22136-22144	CD	denotes	Fourteen
T9447	22145-22149	NNS	denotes	mice
T9449	22150-22152	IN	denotes	of
T9450	22153-22157	DT	denotes	each
T9451	22158-22166	NN	denotes	genotype
T9452	22167-22171	VBD	denotes	were
T9453	22172-22184	RB	denotes	successfully
T9448	22185-22193	VBN	denotes	analyzed
T9454	22194-22200	IN	denotes	during
T9455	22201-22204	DT	denotes	the
T9457	22205-22209	JJ	denotes	dark
T9456	22210-22216	NN	denotes	period
T9458	22217-22219	IN	denotes	of
T9459	22220-22223	DT	denotes	the
T9460	22224-22227	NN	denotes	day
T9461	22227-22228	.	denotes	.
T3401	22242-22245	NN	denotes	IOP
T3402	22246-22257	NNS	denotes	differences
T3403	22258-22261	VBP	denotes	are
T3404	22262-22274	JJ	denotes	reproducible
T3405	22275-22278	CC	denotes	and
T3406	22279-22287	JJ	denotes	amenable
T3407	22288-22290	IN	denotes	to
T3408	22291-22298	JJ	denotes	genetic
T3409	22299-22307	NNS	denotes	analyses
T3410	22307-22428	sentence	denotes	We report the IOPs of over 30 genetically different mouse strains that were housed in the same environmental conditions.
T3411	22308-22310	PRP	denotes	We
T3412	22311-22317	VBP	denotes	report
T3413	22318-22321	DT	denotes	the
T3414	22322-22326	NNS	denotes	IOPs
T3415	22327-22329	IN	denotes	of
T3416	22330-22334	IN	denotes	over
T3417	22335-22337	CD	denotes	30
T3419	22338-22349	RB	denotes	genetically
T3420	22350-22359	JJ	denotes	different
T3421	22360-22365	NN	denotes	mouse
T3418	22366-22373	NNS	denotes	strains
T3422	22374-22378	WDT	denotes	that
T3424	22379-22383	VBD	denotes	were
T3423	22384-22390	VBN	denotes	housed
T3425	22391-22393	IN	denotes	in
T3426	22394-22397	DT	denotes	the
T3428	22398-22402	JJ	denotes	same
T3429	22403-22416	JJ	denotes	environmental
T3427	22417-22427	NNS	denotes	conditions
T3430	22427-22428	.	denotes	.
T3431	22428-22620	sentence	denotes	The magnitude of IOP differences between strains and the good reproducibility of readings over time will allow the use of genetic approaches to identify genes that underlie these differences.
T3432	22429-22432	DT	denotes	The
T3433	22433-22442	NN	denotes	magnitude
T3435	22443-22445	IN	denotes	of
T3436	22446-22449	NN	denotes	IOP
T3437	22450-22461	NNS	denotes	differences
T3438	22462-22469	IN	denotes	between
T3439	22470-22477	NNS	denotes	strains
T3440	22478-22481	CC	denotes	and
T3441	22482-22485	DT	denotes	the
T3443	22486-22490	JJ	denotes	good
T3442	22491-22506	NN	denotes	reproducibility
T3444	22507-22509	IN	denotes	of
T3445	22510-22518	NNS	denotes	readings
T3446	22519-22523	IN	denotes	over
T3447	22524-22528	NN	denotes	time
T3448	22529-22533	MD	denotes	will
T3434	22534-22539	VB	denotes	allow
T3449	22540-22543	DT	denotes	the
T3450	22544-22547	NN	denotes	use
T3451	22548-22550	IN	denotes	of
T3452	22551-22558	JJ	denotes	genetic
T3453	22559-22569	NNS	denotes	approaches
T3454	22570-22572	TO	denotes	to
T3455	22573-22581	VB	denotes	identify
T3456	22582-22587	NNS	denotes	genes
T3457	22588-22592	WDT	denotes	that
T3458	22593-22601	VBP	denotes	underlie
T3459	22602-22607	DT	denotes	these
T3460	22608-22619	NNS	denotes	differences
T3461	22619-22620	.	denotes	.
T3462	22620-22705	sentence	denotes	Using our method, a trained investigator can measure the IOPs of 10 mice in an hour.
T3463	22621-22626	VBG	denotes	Using
T3465	22627-22630	PRP$	denotes	our
T3466	22631-22637	NN	denotes	method
T3467	22637-22639	,	denotes	,
T3468	22639-22640	DT	denotes	a
T3470	22641-22648	JJ	denotes	trained
T3469	22649-22661	NN	denotes	investigator
T3471	22662-22665	MD	denotes	can
T3464	22666-22673	VB	denotes	measure
T3472	22674-22677	DT	denotes	the
T3473	22678-22682	NNS	denotes	IOPs
T3474	22683-22685	IN	denotes	of
T3475	22686-22688	CD	denotes	10
T3476	22689-22693	NNS	denotes	mice
T3477	22694-22696	IN	denotes	in
T3478	22697-22699	DT	denotes	an
T3479	22700-22704	NN	denotes	hour
T3480	22704-22705	.	denotes	.
T3481	22705-22914	sentence	denotes	Thus it is feasible to assess sufficient numbers of mice for quantitative trait locus (QTL) analysis methods and to use these methods to identify chromosomal regions contributing to strain differences in IOP.
T3482	22706-22710	RB	denotes	Thus
T3484	22711-22713	PRP	denotes	it
T3483	22714-22716	VBZ	denotes	is
T3485	22717-22725	JJ	denotes	feasible
T3486	22726-22728	TO	denotes	to
T3487	22729-22735	VB	denotes	assess
T3488	22736-22746	JJ	denotes	sufficient
T3489	22747-22754	NNS	denotes	numbers
T3490	22755-22757	IN	denotes	of
T3491	22758-22762	NNS	denotes	mice
T3492	22763-22766	IN	denotes	for
T3493	22767-22779	JJ	denotes	quantitative
T3495	22780-22785	NN	denotes	trait
T3494	22786-22791	NN	denotes	locus
T3497	22792-22793	-LRB-	denotes	(
T3498	22793-22796	NN	denotes	QTL
T3499	22796-22797	-RRB-	denotes	)
T3500	22798-22806	NN	denotes	analysis
T3496	22807-22814	NNS	denotes	methods
T3501	22815-22818	CC	denotes	and
T3502	22819-22821	TO	denotes	to
T3503	22822-22825	VB	denotes	use
T3504	22826-22831	DT	denotes	these
T3505	22832-22839	NNS	denotes	methods
T3506	22840-22842	TO	denotes	to
T3507	22843-22851	VB	denotes	identify
T3508	22852-22863	JJ	denotes	chromosomal
T3509	22864-22871	NNS	denotes	regions
T3510	22872-22884	VBG	denotes	contributing
T3511	22885-22887	IN	denotes	to
T3512	22888-22894	NN	denotes	strain
T3513	22895-22906	NNS	denotes	differences
T3514	22907-22909	IN	denotes	in
T3515	22910-22913	NN	denotes	IOP
T3516	22913-22914	.	denotes	.
T3517	22914-23005	sentence	denotes	The strain survey we report provides valuable information for designing these experiments.
T3518	22915-22918	DT	denotes	The
T3520	22919-22925	NN	denotes	strain
T3519	22926-22932	NN	denotes	survey
T3522	22933-22935	PRP	denotes	we
T3523	22936-22942	VBP	denotes	report
T3521	22943-22951	VBZ	denotes	provides
T3524	22952-22960	JJ	denotes	valuable
T3525	22961-22972	NN	denotes	information
T3526	22973-22976	IN	denotes	for
T3527	22977-22986	VBG	denotes	designing
T3528	22987-22992	DT	denotes	these
T3529	22993-23004	NNS	denotes	experiments
T3530	23004-23005	.	denotes	.
T3531	23005-23092	sentence	denotes	The throughput and reproducibility also is sufficient for mutagenesis screens [28-30].
T3532	23006-23009	DT	denotes	The
T3533	23010-23020	NN	denotes	throughput
T3535	23021-23024	CC	denotes	and
T3536	23025-23040	NN	denotes	reproducibility
T3537	23041-23045	RB	denotes	also
T3534	23046-23048	VBZ	denotes	is
T3538	23049-23059	JJ	denotes	sufficient
T3539	23060-23063	IN	denotes	for
T3540	23064-23075	NN	denotes	mutagenesis
T3541	23076-23083	NNS	denotes	screens
T3542	23084-23085	-LRB-	denotes	[
T3544	23085-23087	CD	denotes	28
T3545	23087-23088	HYPH	denotes	-
T3543	23088-23090	CD	denotes	30
T3546	23090-23091	-RRB-	denotes	]
T3547	23091-23092	.	denotes	.
T3548	23092-23342	sentence	denotes	These are important approaches as they may allow the association of genes with IOP and glaucoma whose currently known functions do not suggest that they affect aqueous humor dynamics or do not immediately identify them as likely glaucoma candidates.
T3549	23093-23098	DT	denotes	These
T3550	23099-23102	VBP	denotes	are
T3551	23103-23112	JJ	denotes	important
T3552	23113-23123	NNS	denotes	approaches
T3553	23124-23126	IN	denotes	as
T3555	23127-23131	PRP	denotes	they
T3556	23132-23135	MD	denotes	may
T3554	23136-23141	VB	denotes	allow
T3557	23142-23145	DT	denotes	the
T3558	23146-23157	NN	denotes	association
T3559	23158-23160	IN	denotes	of
T3560	23161-23166	NNS	denotes	genes
T3561	23167-23171	IN	denotes	with
T3562	23172-23175	NN	denotes	IOP
T3563	23176-23179	CC	denotes	and
T3564	23180-23188	NN	denotes	glaucoma
T3565	23189-23194	WP$	denotes	whose
T3567	23195-23204	RB	denotes	currently
T3568	23205-23210	VBN	denotes	known
T3566	23211-23220	NNS	denotes	functions
T3570	23221-23223	VBP	denotes	do
T3571	23224-23227	RB	denotes	not
T3569	23228-23235	VB	denotes	suggest
T3572	23236-23240	IN	denotes	that
T3574	23241-23245	PRP	denotes	they
T3573	23246-23252	VBP	denotes	affect
T3575	23253-23260	JJ	denotes	aqueous
T3576	23261-23266	NN	denotes	humor
T3577	23267-23275	NNS	denotes	dynamics
T3578	23276-23278	CC	denotes	or
T3579	23279-23281	VBP	denotes	do
T3581	23282-23285	RB	denotes	not
T3582	23286-23297	RB	denotes	immediately
T3580	23298-23306	VB	denotes	identify
T3583	23307-23311	PRP	denotes	them
T3584	23312-23314	IN	denotes	as
T3585	23315-23321	JJ	denotes	likely
T3587	23322-23330	NN	denotes	glaucoma
T3586	23331-23341	NNS	denotes	candidates
T3588	23341-23342	.	denotes	.
T3628	23344-23346	DT	denotes	No
T3629	23347-23353	NN	denotes	effect
T3630	23354-23356	IN	denotes	of
T3631	23357-23367	JJ	denotes	anesthetic
T3632	23368-23376	NN	denotes	protocol
T3633	23377-23379	IN	denotes	on
T3634	23380-23383	NN	denotes	IOP
T3635	23384-23390	IN	denotes	during
T3636	23391-23392	DT	denotes	a
T3638	23393-23395	CD	denotes	12
T3639	23396-23402	NN	denotes	minute
T3640	23403-23414	NN	denotes	measurement
T3637	23415-23421	NN	denotes	window
T3641	23421-23474	sentence	denotes	Many anesthetic agents including xylazine lower IOP.
T3642	23422-23426	JJ	denotes	Many
T3644	23427-23437	JJ	denotes	anesthetic
T3643	23438-23444	NNS	denotes	agents
T3646	23445-23454	VBG	denotes	including
T3647	23455-23463	NN	denotes	xylazine
T3645	23464-23469	VBP	denotes	lower
T3648	23470-23473	NN	denotes	IOP
T3649	23473-23474	.	denotes	.
T3650	23474-23612	sentence	denotes	Ketamine usually appears to increase IOP [31-33], but there are reports of ketamine having no effect on IOP or even reducing IOP [31,34].
T3651	23475-23483	NN	denotes	Ketamine
T3653	23484-23491	RB	denotes	usually
T3652	23492-23499	VBZ	denotes	appears
T3654	23500-23502	TO	denotes	to
T3655	23503-23511	VB	denotes	increase
T3656	23512-23515	NN	denotes	IOP
T3657	23516-23517	-LRB-	denotes	[
T3659	23517-23519	CD	denotes	31
T3660	23519-23520	HYPH	denotes	-
T3658	23520-23522	CD	denotes	33
T3661	23522-23523	-RRB-	denotes	]
T3662	23523-23525	,	denotes	,
T3663	23525-23528	CC	denotes	but
T3664	23529-23534	EX	denotes	there
T3665	23535-23538	VBP	denotes	are
T3666	23539-23546	NNS	denotes	reports
T3667	23547-23549	IN	denotes	of
T3668	23550-23558	NN	denotes	ketamine
T3670	23559-23565	VBG	denotes	having
T3672	23566-23568	DT	denotes	no
T3671	23569-23575	NN	denotes	effect
T3673	23576-23578	IN	denotes	on
T3674	23579-23582	NN	denotes	IOP
T3675	23583-23585	CC	denotes	or
T3676	23586-23590	RB	denotes	even
T3669	23591-23599	VBG	denotes	reducing
T3677	23600-23603	NN	denotes	IOP
T3678	23604-23605	-LRB-	denotes	[
T3680	23605-23607	CD	denotes	31
T3681	23607-23608	,	denotes	,
T3679	23608-23610	CD	denotes	34
T3682	23610-23611	-RRB-	denotes	]
T3683	23611-23612	.	denotes	.
T3684	23612-23721	sentence	denotes	Different doses, species used, routes of administration or environments may contribute to these differences.
T3685	23613-23622	JJ	denotes	Different
T3686	23623-23628	NNS	denotes	doses
T3688	23628-23630	,	denotes	,
T3689	23630-23637	NNS	denotes	species
T3690	23638-23642	VBN	denotes	used
T3691	23642-23644	,	denotes	,
T3692	23644-23650	NNS	denotes	routes
T3693	23651-23653	IN	denotes	of
T3694	23654-23668	NN	denotes	administration
T3695	23669-23671	CC	denotes	or
T3696	23672-23684	NNS	denotes	environments
T3697	23685-23688	MD	denotes	may
T3687	23689-23699	VB	denotes	contribute
T3698	23700-23702	IN	denotes	to
T3699	23703-23708	DT	denotes	these
T3700	23709-23720	NNS	denotes	differences
T3701	23720-23721	.	denotes	.
T3702	23721-23916	sentence	denotes	The relationship between the IOPs we measure and those in conscious mice depends upon the effect of our anesthetic protocol (intraperitoneal injection of 99 mg/kg ketamine and 9 mg/kg xylazine).
T3703	23722-23725	DT	denotes	The
T3704	23726-23738	NN	denotes	relationship
T3706	23739-23746	IN	denotes	between
T3707	23747-23750	DT	denotes	the
T3708	23751-23755	NNS	denotes	IOPs
T3709	23756-23758	PRP	denotes	we
T3710	23759-23766	VBP	denotes	measure
T3711	23767-23770	CC	denotes	and
T3712	23771-23776	DT	denotes	those
T3713	23777-23779	IN	denotes	in
T3714	23780-23789	JJ	denotes	conscious
T3715	23790-23794	NNS	denotes	mice
T3705	23795-23802	VBZ	denotes	depends
T3716	23803-23807	IN	denotes	upon
T3717	23808-23811	DT	denotes	the
T3718	23812-23818	NN	denotes	effect
T3719	23819-23821	IN	denotes	of
T3720	23822-23825	PRP$	denotes	our
T3722	23826-23836	JJ	denotes	anesthetic
T3721	23837-23845	NN	denotes	protocol
T3723	23846-23847	-LRB-	denotes	(
T3724	23847-23862	JJ	denotes	intraperitoneal
T3725	23863-23872	NN	denotes	injection
T3726	23873-23875	IN	denotes	of
T3727	23876-23878	CD	denotes	99
T3728	23879-23881	NNS	denotes	mg
T3730	23881-23882	SYM	denotes	/
T3731	23882-23884	NN	denotes	kg
T3729	23885-23893	NN	denotes	ketamine
T3732	23894-23897	CC	denotes	and
T3733	23898-23899	CD	denotes	9
T3734	23900-23902	NNS	denotes	mg
T3736	23902-23903	SYM	denotes	/
T3737	23903-23905	NN	denotes	kg
T3735	23906-23914	NN	denotes	xylazine
T3738	23914-23915	-RRB-	denotes	)
T3739	23915-23916	.	denotes	.
T3740	23916-24017	sentence	denotes	An anesthetic effect could potentially alter IOP and mask genetically determined differences in IOP.
T3741	23917-23919	DT	denotes	An
T3743	23920-23930	JJ	denotes	anesthetic
T3742	23931-23937	NN	denotes	effect
T3745	23938-23943	MD	denotes	could
T3746	23944-23955	RB	denotes	potentially
T3744	23956-23961	VB	denotes	alter
T3747	23962-23965	NN	denotes	IOP
T3748	23966-23969	CC	denotes	and
T3749	23970-23974	VB	denotes	mask
T3750	23975-23986	RB	denotes	genetically
T3751	23987-23997	VBN	denotes	determined
T3752	23998-24009	NNS	denotes	differences
T3753	24010-24012	IN	denotes	in
T3754	24013-24016	NN	denotes	IOP
T3755	24016-24017	.	denotes	.
T3756	24017-24076	sentence	denotes	Therefore, it is very important to understand this effect.
T3757	24018-24027	RB	denotes	Therefore
T3759	24027-24029	,	denotes	,
T3760	24029-24031	PRP	denotes	it
T3758	24032-24034	VBZ	denotes	is
T3761	24035-24039	RB	denotes	very
T3762	24040-24049	JJ	denotes	important
T3763	24050-24052	TO	denotes	to
T3764	24053-24063	VB	denotes	understand
T3765	24064-24068	DT	denotes	this
T3766	24069-24075	NN	denotes	effect
T3767	24075-24076	.	denotes	.
T3768	24076-24252	sentence	denotes	Here, we show that, despite a depressant effect on IOP by 25 minutes, our anesthetic protocol has no detectable effect on IOP during the first 12 minutes after administration.
T3769	24077-24081	RB	denotes	Here
T3771	24081-24083	,	denotes	,
T3772	24083-24085	PRP	denotes	we
T3770	24086-24090	VBP	denotes	show
T3773	24091-24095	IN	denotes	that
T3775	24095-24097	,	denotes	,
T3776	24097-24104	IN	denotes	despite
T3777	24105-24106	DT	denotes	a
T3779	24107-24117	NN	denotes	depressant
T3778	24118-24124	NN	denotes	effect
T3780	24125-24127	IN	denotes	on
T3781	24128-24131	NN	denotes	IOP
T3782	24132-24134	IN	denotes	by
T3783	24135-24137	CD	denotes	25
T3784	24138-24145	NNS	denotes	minutes
T3785	24145-24147	,	denotes	,
T3786	24147-24150	PRP$	denotes	our
T3788	24151-24161	JJ	denotes	anesthetic
T3787	24162-24170	NN	denotes	protocol
T3774	24171-24174	VBZ	denotes	has
T3789	24175-24177	DT	denotes	no
T3791	24178-24188	JJ	denotes	detectable
T3790	24189-24195	NN	denotes	effect
T3792	24196-24198	IN	denotes	on
T3793	24199-24202	NN	denotes	IOP
T3794	24203-24209	IN	denotes	during
T3795	24210-24213	DT	denotes	the
T3797	24214-24219	JJ	denotes	first
T3796	24220-24222	CD	denotes	12
T3798	24223-24230	NNS	denotes	minutes
T3799	24231-24236	IN	denotes	after
T3800	24237-24251	NN	denotes	administration
T3801	24251-24252	.	denotes	.
T3802	24252-24398	sentence	denotes	Thus, to avoid effects of anesthesia on IOP, all measurements should be made within a window of up to 12 minutes after anesthetic administration.
T3803	24253-24257	RB	denotes	Thus
T3805	24257-24259	,	denotes	,
T3806	24259-24261	TO	denotes	to
T3807	24262-24267	VB	denotes	avoid
T3808	24268-24275	NNS	denotes	effects
T3809	24276-24278	IN	denotes	of
T3810	24279-24289	NN	denotes	anesthesia
T3811	24290-24292	IN	denotes	on
T3812	24293-24296	NNP	denotes	IOP
T3813	24296-24298	,	denotes	,
T3814	24298-24301	DT	denotes	all
T3815	24302-24314	NNS	denotes	measurements
T3816	24315-24321	MD	denotes	should
T3817	24322-24324	VB	denotes	be
T3804	24325-24329	VBN	denotes	made
T3818	24330-24336	IN	denotes	within
T3819	24337-24338	DT	denotes	a
T3820	24339-24345	NN	denotes	window
T3821	24346-24348	IN	denotes	of
T3822	24349-24351	IN	denotes	up
T3824	24352-24354	IN	denotes	to
T3823	24355-24357	CD	denotes	12
T3825	24358-24365	NNS	denotes	minutes
T3826	24366-24371	IN	denotes	after
T3827	24372-24382	JJ	denotes	anesthetic
T3828	24383-24397	NN	denotes	administration
T3829	24397-24398	.	denotes	.
T3830	24398-24443	sentence	denotes	Similarities and differences to rat studies
T3831	24400-24412	NNS	denotes	Similarities
T3832	24413-24416	CC	denotes	and
T3833	24417-24428	NNS	denotes	differences
T3834	24429-24431	IN	denotes	to
T3835	24432-24435	NN	denotes	rat
T3836	24436-24443	NNS	denotes	studies
T3837	24443-24586	sentence	denotes	Our results agree with the time course of cardiovascular depression caused by intraperitoneal administration of ketamine and xylazine in rats.
T3838	24444-24447	PRP$	denotes	Our
T3839	24448-24455	NNS	denotes	results
T3840	24456-24461	VBP	denotes	agree
T3841	24462-24466	IN	denotes	with
T3842	24467-24470	DT	denotes	the
T3844	24471-24475	NN	denotes	time
T3843	24476-24482	NN	denotes	course
T3845	24483-24485	IN	denotes	of
T3846	24486-24500	JJ	denotes	cardiovascular
T3847	24501-24511	NN	denotes	depression
T3848	24512-24518	VBN	denotes	caused
T3849	24519-24521	IN	denotes	by
T3850	24522-24537	JJ	denotes	intraperitoneal
T3851	24538-24552	NN	denotes	administration
T3852	24553-24555	IN	denotes	of
T3853	24556-24564	NN	denotes	ketamine
T3854	24565-24568	CC	denotes	and
T3855	24569-24577	NN	denotes	xylazine
T3856	24578-24580	IN	denotes	in
T3857	24581-24585	NNS	denotes	rats
T3858	24585-24586	.	denotes	.
T3859	24586-24798	sentence	denotes	In that study, anesthesia had a minor effect on blood pressure during the first 15 minutes following injection but a strong hypotensive effect between 15 and 30 minutes that continued for more than an hour [35].
T3860	24587-24589	IN	denotes	In
T3862	24590-24594	DT	denotes	that
T3863	24595-24600	NN	denotes	study
T3864	24600-24602	,	denotes	,
T3865	24602-24612	NN	denotes	anesthesia
T3861	24613-24616	VBD	denotes	had
T3866	24617-24618	DT	denotes	a
T3868	24619-24624	JJ	denotes	minor
T3867	24625-24631	NN	denotes	effect
T3869	24632-24634	IN	denotes	on
T3870	24635-24640	NN	denotes	blood
T3871	24641-24649	NN	denotes	pressure
T3872	24650-24656	IN	denotes	during
T3873	24657-24660	DT	denotes	the
T3875	24661-24666	JJ	denotes	first
T3874	24667-24669	CD	denotes	15
T3876	24670-24677	NNS	denotes	minutes
T3877	24678-24687	VBG	denotes	following
T3878	24688-24697	NN	denotes	injection
T3879	24698-24701	CC	denotes	but
T3880	24702-24703	DT	denotes	a
T3882	24704-24710	JJ	denotes	strong
T3883	24711-24722	JJ	denotes	hypotensive
T3881	24723-24729	NN	denotes	effect
T3884	24730-24737	IN	denotes	between
T3885	24738-24740	CD	denotes	15
T3887	24741-24744	CC	denotes	and
T3888	24745-24747	CD	denotes	30
T3886	24748-24755	NNS	denotes	minutes
T3889	24756-24760	WDT	denotes	that
T3890	24761-24770	VBD	denotes	continued
T3891	24771-24774	IN	denotes	for
T3892	24775-24779	JJR	denotes	more
T3894	24780-24784	IN	denotes	than
T3893	24785-24787	DT	denotes	an
T3895	24788-24792	NN	denotes	hour
T3896	24793-24794	-LRB-	denotes	[
T3897	24794-24796	CD	denotes	35
T3898	24796-24797	-RRB-	denotes	]
T3899	24797-24798	.	denotes	.
T3900	24798-24928	sentence	denotes	In contrast, intraperitoneally administered ketamine (100 mg/kg) was shown to rapidly decrease IOP in a different rat study [36].
T3901	24799-24801	IN	denotes	In
T3903	24802-24810	NN	denotes	contrast
T3904	24810-24812	,	denotes	,
T3905	24812-24829	RB	denotes	intraperitoneally
T3906	24830-24842	VBN	denotes	administered
T3907	24843-24851	NN	denotes	ketamine
T3908	24852-24853	-LRB-	denotes	(
T3910	24853-24856	CD	denotes	100
T3909	24857-24859	NNS	denotes	mg
T3911	24859-24860	SYM	denotes	/
T3912	24860-24862	NN	denotes	kg
T3913	24862-24863	-RRB-	denotes	)
T3914	24864-24867	VBD	denotes	was
T3902	24868-24873	VBN	denotes	shown
T3915	24874-24876	TO	denotes	to
T3917	24877-24884	RB	denotes	rapidly
T3916	24885-24893	VB	denotes	decrease
T3918	24894-24897	NN	denotes	IOP
T3919	24898-24900	IN	denotes	in
T3920	24901-24902	DT	denotes	a
T3922	24903-24912	JJ	denotes	different
T3923	24913-24916	NN	denotes	rat
T3921	24917-24922	NN	denotes	study
T3924	24923-24924	-LRB-	denotes	[
T3925	24924-24926	CD	denotes	36
T3926	24926-24927	-RRB-	denotes	]
T3927	24927-24928	.	denotes	.
T3928	24928-25061	sentence	denotes	IOP decreased significantly between a conscious measurement and the first possible measurement under anesthesia (defined as time 0).
T3929	24929-24932	NN	denotes	IOP
T3930	24933-24942	VBD	denotes	decreased
T3931	24943-24956	RB	denotes	significantly
T3932	24957-24964	IN	denotes	between
T3933	24965-24966	DT	denotes	a
T3935	24967-24976	JJ	denotes	conscious
T3934	24977-24988	NN	denotes	measurement
T3936	24989-24992	CC	denotes	and
T3937	24993-24996	DT	denotes	the
T3939	24997-25002	JJ	denotes	first
T3940	25003-25011	JJ	denotes	possible
T3938	25012-25023	NN	denotes	measurement
T3941	25024-25029	IN	denotes	under
T3942	25030-25040	NN	denotes	anesthesia
T3943	25041-25042	-LRB-	denotes	(
T3944	25042-25049	VBN	denotes	defined
T3945	25050-25052	IN	denotes	as
T3946	25053-25057	NN	denotes	time
T3947	25058-25059	CD	denotes	0
T3948	25059-25060	-RRB-	denotes	)
T3949	25060-25061	.	denotes	.
T3950	25061-25202	sentence	denotes	IOP decreased further by the next reading (at 5 minutes) after which it remained stable for the duration of the experiment (20 minutes)[36].
T3951	25062-25065	NN	denotes	IOP
T3952	25066-25075	VBD	denotes	decreased
T3953	25076-25083	RB	denotes	further
T3954	25084-25086	IN	denotes	by
T3955	25087-25090	DT	denotes	the
T3957	25091-25095	JJ	denotes	next
T3956	25096-25103	NN	denotes	reading
T3958	25104-25105	-LRB-	denotes	(
T3959	25105-25107	IN	denotes	at
T3960	25108-25109	CD	denotes	5
T3961	25110-25117	NNS	denotes	minutes
T3962	25117-25118	-RRB-	denotes	)
T3963	25119-25124	IN	denotes	after
T3965	25125-25130	WDT	denotes	which
T3966	25131-25133	PRP	denotes	it
T3964	25134-25142	VBD	denotes	remained
T3967	25143-25149	JJ	denotes	stable
T3968	25150-25153	IN	denotes	for
T3969	25154-25157	DT	denotes	the
T3970	25158-25166	NN	denotes	duration
T3971	25167-25169	IN	denotes	of
T3972	25170-25173	DT	denotes	the
T3973	25174-25184	NN	denotes	experiment
T3974	25185-25186	-LRB-	denotes	(
T3975	25186-25188	CD	denotes	20
T3976	25189-25196	NNS	denotes	minutes
T3977	25196-25197	-RRB-	denotes	)
T3978	25197-25198	-LRB-	denotes	[
T3979	25198-25200	CD	denotes	36
T3980	25200-25201	-RRB-	denotes	]
T3981	25201-25202	.	denotes	.
T3982	25202-25484	sentence	denotes	The time 0 measurement in that study was at a very similar state of anesthesia as our 4 and 5 minute time points (starting as soon as possible and within 20 to 60 seconds of adequate anesthesia), and the 5 minute rat time point was similar to our 9 and 10 minute measurement times.
T3983	25203-25206	DT	denotes	The
T3985	25207-25211	NN	denotes	time
T3986	25212-25213	CD	denotes	0
T3984	25214-25225	NN	denotes	measurement
T3988	25226-25228	IN	denotes	in
T3989	25229-25233	DT	denotes	that
T3990	25234-25239	NN	denotes	study
T3987	25240-25243	VBD	denotes	was
T3991	25244-25246	IN	denotes	at
T3992	25247-25248	DT	denotes	a
T3994	25249-25253	RB	denotes	very
T3995	25254-25261	JJ	denotes	similar
T3993	25262-25267	NN	denotes	state
T3996	25268-25270	IN	denotes	of
T3997	25271-25281	NN	denotes	anesthesia
T3998	25282-25284	IN	denotes	as
T3999	25285-25288	PRP$	denotes	our
T4001	25289-25290	CD	denotes	4
T4003	25291-25294	CC	denotes	and
T4004	25295-25296	CD	denotes	5
T4002	25297-25303	JJ	denotes	minute
T4005	25304-25308	NN	denotes	time
T4000	25309-25315	NNS	denotes	points
T4006	25316-25317	-LRB-	denotes	(
T4007	25317-25325	VBG	denotes	starting
T4008	25326-25328	RB	denotes	as
T4009	25329-25333	RB	denotes	soon
T4011	25334-25336	IN	denotes	as
T4012	25337-25345	JJ	denotes	possible
T4013	25346-25349	CC	denotes	and
T4010	25350-25356	IN	denotes	within
T4014	25357-25359	CD	denotes	20
T4016	25360-25362	IN	denotes	to
T4015	25363-25365	CD	denotes	60
T4017	25366-25373	NNS	denotes	seconds
T4018	25374-25376	IN	denotes	of
T4019	25377-25385	JJ	denotes	adequate
T4020	25386-25396	NN	denotes	anesthesia
T4021	25396-25397	-RRB-	denotes	)
T4022	25397-25399	,	denotes	,
T4023	25399-25402	CC	denotes	and
T4024	25403-25406	DT	denotes	the
T4026	25407-25408	CD	denotes	5
T4027	25409-25415	JJ	denotes	minute
T4028	25416-25419	NN	denotes	rat
T4029	25420-25424	NN	denotes	time
T4025	25425-25430	NN	denotes	point
T4030	25431-25434	VBD	denotes	was
T4031	25435-25442	JJ	denotes	similar
T4032	25443-25445	IN	denotes	to
T4033	25446-25449	PRP$	denotes	our
T4035	25450-25451	CD	denotes	9
T4037	25452-25455	CC	denotes	and
T4038	25456-25458	CD	denotes	10
T4036	25459-25465	JJ	denotes	minute
T4039	25466-25477	NN	denotes	measurement
T4034	25478-25483	NNS	denotes	times
T4040	25483-25484	.	denotes	.
T4041	25484-25616	sentence	denotes	Thus, although both rat and mouse studies show that anesthesia decreases IOP, the studies do not agree on the timing of the effect.
T4042	25485-25489	RB	denotes	Thus
T4044	25489-25491	,	denotes	,
T4045	25491-25499	IN	denotes	although
T4047	25500-25504	CC	denotes	both
T4049	25505-25508	NN	denotes	rat
T4050	25509-25512	CC	denotes	and
T4051	25513-25518	NN	denotes	mouse
T4048	25519-25526	NNS	denotes	studies
T4046	25527-25531	VBP	denotes	show
T4052	25532-25536	IN	denotes	that
T4054	25537-25547	NN	denotes	anesthesia
T4053	25548-25557	VBZ	denotes	decreases
T4055	25558-25561	NNP	denotes	IOP
T4056	25561-25563	,	denotes	,
T4057	25563-25566	DT	denotes	the
T4058	25567-25574	NNS	denotes	studies
T4059	25575-25577	VBP	denotes	do
T4060	25578-25581	RB	denotes	not
T4043	25582-25587	VB	denotes	agree
T4061	25588-25590	IN	denotes	on
T4062	25591-25594	DT	denotes	the
T4063	25595-25601	NN	denotes	timing
T4064	25602-25604	IN	denotes	of
T4065	25605-25608	DT	denotes	the
T4066	25609-25615	NN	denotes	effect
T4067	25615-25616	.	denotes	.
T4068	25616-25712	sentence	denotes	The IOP depression occurred very soon after anesthesia in the rats but was delayed in the mice.
T4069	25617-25620	DT	denotes	The
T4071	25621-25624	NNP	denotes	IOP
T4070	25625-25635	NN	denotes	depression
T4072	25636-25644	VBD	denotes	occurred
T4073	25645-25649	RB	denotes	very
T4074	25650-25654	RB	denotes	soon
T4075	25655-25660	IN	denotes	after
T4076	25661-25671	NN	denotes	anesthesia
T4077	25672-25674	IN	denotes	in
T4078	25675-25678	DT	denotes	the
T4079	25679-25683	NNS	denotes	rats
T4080	25684-25687	CC	denotes	but
T4081	25688-25691	VBD	denotes	was
T4082	25692-25699	VBN	denotes	delayed
T4083	25700-25702	IN	denotes	in
T4084	25703-25706	DT	denotes	the
T4085	25707-25711	NNS	denotes	mice
T4086	25711-25712	.	denotes	.
T4158	25714-25725	NN	denotes	Environment
T4160	25726-25729	MD	denotes	may
T4159	25730-25739	VB	denotes	influence
T4161	25740-25743	DT	denotes	the
T4162	25744-25750	NN	denotes	effect
T4163	25751-25753	IN	denotes	of
T4164	25754-25764	NN	denotes	anesthesia
T4165	25764-25866	sentence	denotes	Factors that may influence the effect of anesthesia include the species, strain and environment used.
T4166	25765-25772	NNS	denotes	Factors
T4168	25773-25777	WDT	denotes	that
T4170	25778-25781	MD	denotes	may
T4169	25782-25791	VB	denotes	influence
T4171	25792-25795	DT	denotes	the
T4172	25796-25802	NN	denotes	effect
T4173	25803-25805	IN	denotes	of
T4174	25806-25816	NN	denotes	anesthesia
T4167	25817-25824	VBP	denotes	include
T4175	25825-25828	DT	denotes	the
T4176	25829-25836	NN	denotes	species
T4177	25836-25838	,	denotes	,
T4178	25838-25844	NN	denotes	strain
T4179	25845-25848	CC	denotes	and
T4180	25849-25860	NN	denotes	environment
T4181	25861-25865	VBN	denotes	used
T4182	25865-25866	.	denotes	.
T4183	25866-25980	sentence	denotes	Essentially the same dose of ketamine and route of administration was used in both the rat and mouse IOP studies.
T4184	25867-25878	RB	denotes	Essentially
T4186	25879-25882	DT	denotes	the
T4187	25883-25887	JJ	denotes	same
T4185	25888-25892	NN	denotes	dose
T4189	25893-25895	IN	denotes	of
T4190	25896-25904	NN	denotes	ketamine
T4191	25905-25908	CC	denotes	and
T4192	25909-25914	NN	denotes	route
T4193	25915-25917	IN	denotes	of
T4194	25918-25932	NN	denotes	administration
T4195	25933-25936	VBD	denotes	was
T4188	25937-25941	VBN	denotes	used
T4196	25942-25944	IN	denotes	in
T4197	25945-25949	CC	denotes	both
T4199	25950-25953	DT	denotes	the
T4200	25954-25957	NN	denotes	rat
T4202	25958-25961	CC	denotes	and
T4203	25962-25967	NN	denotes	mouse
T4201	25968-25971	NN	denotes	IOP
T4198	25972-25979	NNS	denotes	studies
T4204	25979-25980	.	denotes	.
T4205	25980-26241	sentence	denotes	In mice, the strain does not appear to be important as no early effect of anesthesia was present in the three distantly related laboratory strains [37] we studied in detail, and we have not observed any obvious effect during this period in any analyzed strain.
T4206	25981-25983	IN	denotes	In
T4208	25984-25988	NNS	denotes	mice
T4209	25988-25990	,	denotes	,
T4210	25990-25993	DT	denotes	the
T4211	25994-26000	NN	denotes	strain
T4212	26001-26005	VBZ	denotes	does
T4213	26006-26009	RB	denotes	not
T4207	26010-26016	VB	denotes	appear
T4214	26017-26019	TO	denotes	to
T4215	26020-26022	VB	denotes	be
T4216	26023-26032	JJ	denotes	important
T4217	26033-26035	IN	denotes	as
T4219	26036-26038	DT	denotes	no
T4221	26039-26044	JJ	denotes	early
T4220	26045-26051	NN	denotes	effect
T4222	26052-26054	IN	denotes	of
T4223	26055-26065	NN	denotes	anesthesia
T4218	26066-26069	VBD	denotes	was
T4224	26070-26077	JJ	denotes	present
T4225	26078-26080	IN	denotes	in
T4226	26081-26084	DT	denotes	the
T4228	26085-26090	CD	denotes	three
T4229	26091-26100	RB	denotes	distantly
T4230	26101-26108	JJ	denotes	related
T4231	26109-26119	NN	denotes	laboratory
T4227	26120-26127	NNS	denotes	strains
T4232	26128-26129	-LRB-	denotes	[
T4233	26129-26131	CD	denotes	37
T4234	26131-26132	-RRB-	denotes	]
T4235	26133-26135	PRP	denotes	we
T4236	26136-26143	VBD	denotes	studied
T4237	26144-26146	IN	denotes	in
T4238	26147-26153	NN	denotes	detail
T4239	26153-26155	,	denotes	,
T4240	26155-26158	CC	denotes	and
T4241	26159-26161	PRP	denotes	we
T4243	26162-26166	VBP	denotes	have
T4244	26167-26170	RB	denotes	not
T4242	26171-26179	VBN	denotes	observed
T4245	26180-26183	DT	denotes	any
T4247	26184-26191	JJ	denotes	obvious
T4246	26192-26198	NN	denotes	effect
T4248	26199-26205	IN	denotes	during
T4249	26206-26210	DT	denotes	this
T4250	26211-26217	NN	denotes	period
T4251	26218-26220	IN	denotes	in
T4252	26221-26224	DT	denotes	any
T4254	26225-26233	VBN	denotes	analyzed
T4253	26234-26240	NN	denotes	strain
T4255	26240-26241	.	denotes	.
T4256	26241-26285	sentence	denotes	Environmental differences may be important.
T4257	26242-26255	JJ	denotes	Environmental
T4258	26256-26267	NNS	denotes	differences
T4260	26268-26271	MD	denotes	may
T4259	26272-26274	VB	denotes	be
T4261	26275-26284	JJ	denotes	important
T4262	26284-26285	.	denotes	.
T4263	26285-26414	sentence	denotes	Cage cleanliness, changing frequency and housing density can alter drug metabolism and the effect of anesthesia in rats [38,39].
T4264	26286-26290	NN	denotes	Cage
T4265	26291-26302	NN	denotes	cleanliness
T4267	26302-26304	,	denotes	,
T4268	26304-26312	NN	denotes	changing
T4269	26313-26322	NN	denotes	frequency
T4270	26323-26326	CC	denotes	and
T4271	26327-26334	NN	denotes	housing
T4272	26335-26342	NN	denotes	density
T4273	26343-26346	MD	denotes	can
T4266	26347-26352	VB	denotes	alter
T4274	26353-26357	NN	denotes	drug
T4275	26358-26368	NN	denotes	metabolism
T4276	26369-26372	CC	denotes	and
T4277	26373-26376	DT	denotes	the
T4278	26377-26383	NN	denotes	effect
T4279	26384-26386	IN	denotes	of
T4280	26387-26397	NN	denotes	anesthesia
T4281	26398-26400	IN	denotes	in
T4282	26401-26405	NNS	denotes	rats
T4283	26406-26407	-LRB-	denotes	[
T4285	26407-26409	CD	denotes	38
T4286	26409-26410	,	denotes	,
T4284	26410-26412	CD	denotes	39
T4287	26412-26413	-RRB-	denotes	]
T4288	26413-26414	.	denotes	.
T4289	26414-26462	sentence	denotes	The type of bedding used also may be important.
T4290	26415-26418	DT	denotes	The
T4291	26419-26423	NN	denotes	type
T4293	26424-26426	IN	denotes	of
T4294	26427-26434	NN	denotes	bedding
T4295	26435-26439	VBN	denotes	used
T4296	26440-26444	RB	denotes	also
T4297	26445-26448	MD	denotes	may
T4292	26449-26451	VB	denotes	be
T4298	26452-26461	JJ	denotes	important
T4299	26461-26462	.	denotes	.
T4300	26462-26542	sentence	denotes	We use wood shavings for bedding and wood shavings expose the mice to terpenes.
T4301	26463-26465	PRP	denotes	We
T4302	26466-26469	VBP	denotes	use
T4303	26470-26474	NN	denotes	wood
T4304	26475-26483	NNS	denotes	shavings
T4305	26484-26487	IN	denotes	for
T4306	26488-26495	NN	denotes	bedding
T4307	26496-26499	CC	denotes	and
T4308	26500-26504	NN	denotes	wood
T4309	26505-26513	NNS	denotes	shavings
T4310	26514-26520	VBP	denotes	expose
T4311	26521-26524	DT	denotes	the
T4312	26525-26529	NNS	denotes	mice
T4313	26530-26532	IN	denotes	to
T4314	26533-26541	NNS	denotes	terpenes
T4315	26541-26542	.	denotes	.
T4316	26542-26720	sentence	denotes	Terpene administration or environmental exposure to terpenes in wood shavings alters drug resistance and decreases the effect of anesthetic agents in both rats and mice [40-45].
T4317	26543-26550	NN	denotes	Terpene
T4318	26551-26565	NN	denotes	administration
T4320	26566-26568	CC	denotes	or
T4321	26569-26582	JJ	denotes	environmental
T4322	26583-26591	NN	denotes	exposure
T4323	26592-26594	IN	denotes	to
T4324	26595-26603	NNS	denotes	terpenes
T4325	26604-26606	IN	denotes	in
T4326	26607-26611	NN	denotes	wood
T4327	26612-26620	NNS	denotes	shavings
T4319	26621-26627	VBZ	denotes	alters
T4328	26628-26632	NN	denotes	drug
T4329	26633-26643	NN	denotes	resistance
T4330	26644-26647	CC	denotes	and
T4331	26648-26657	VBZ	denotes	decreases
T4332	26658-26661	DT	denotes	the
T4333	26662-26668	NN	denotes	effect
T4334	26669-26671	IN	denotes	of
T4335	26672-26682	JJ	denotes	anesthetic
T4336	26683-26689	NNS	denotes	agents
T4337	26690-26692	IN	denotes	in
T4338	26693-26697	CC	denotes	both
T4339	26698-26702	NNS	denotes	rats
T4340	26703-26706	CC	denotes	and
T4341	26707-26711	NNS	denotes	mice
T4342	26712-26713	-LRB-	denotes	[
T4343	26713-26715	CD	denotes	40
T4344	26715-26716	SYM	denotes	-
T4345	26716-26718	CD	denotes	45
T4346	26718-26719	-RRB-	denotes	]
T4347	26719-26720	.	denotes	.
T4408	26722-26726	NN	denotes	Risk
T4409	26727-26734	NNS	denotes	factors
T4410	26735-26738	IN	denotes	for
T4411	26739-26748	VBN	denotes	increased
T4412	26749-26752	NN	denotes	IOP
T4413	26752-26932	sentence	denotes	Some epidemiological studies implicate factors such as diabetes, vascular hypertension, arterial hypotension, vasospasm, aberrant autoregulation of blood flow and sex in glaucoma.
T4414	26753-26757	DT	denotes	Some
T4416	26758-26773	JJ	denotes	epidemiological
T4415	26774-26781	NNS	denotes	studies
T4417	26782-26791	VBP	denotes	implicate
T4418	26792-26799	NNS	denotes	factors
T4419	26800-26804	JJ	denotes	such
T4420	26805-26807	IN	denotes	as
T4421	26808-26816	NN	denotes	diabetes
T4422	26816-26818	,	denotes	,
T4423	26818-26826	JJ	denotes	vascular
T4424	26827-26839	NN	denotes	hypertension
T4425	26839-26841	,	denotes	,
T4426	26841-26849	JJ	denotes	arterial
T4427	26850-26861	NN	denotes	hypotension
T4428	26861-26863	,	denotes	,
T4429	26863-26872	NN	denotes	vasospasm
T4430	26872-26874	,	denotes	,
T4431	26874-26882	JJ	denotes	aberrant
T4432	26883-26897	NN	denotes	autoregulation
T4433	26898-26900	IN	denotes	of
T4434	26901-26906	NN	denotes	blood
T4435	26907-26911	NN	denotes	flow
T4436	26912-26915	CC	denotes	and
T4437	26916-26919	NN	denotes	sex
T4438	26920-26922	IN	denotes	in
T4439	26923-26931	NN	denotes	glaucoma
T4440	26931-26932	.	denotes	.
T4441	26932-27012	sentence	denotes	Other studies find no association between these factors and glaucoma [2,46-48].
T4442	26933-26938	JJ	denotes	Other
T4443	26939-26946	NNS	denotes	studies
T4444	26947-26951	VBP	denotes	find
T4445	26952-26954	DT	denotes	no
T4446	26955-26966	NN	denotes	association
T4447	26967-26974	IN	denotes	between
T4448	26975-26980	DT	denotes	these
T4449	26981-26988	NNS	denotes	factors
T4450	26989-26992	CC	denotes	and
T4451	26993-27001	NN	denotes	glaucoma
T4452	27002-27003	-LRB-	denotes	[
T4454	27003-27004	CD	denotes	2
T4455	27004-27005	,	denotes	,
T4453	27005-27007	CD	denotes	46
T4456	27007-27008	SYM	denotes	-
T4457	27008-27010	CD	denotes	48
T4458	27010-27011	-RRB-	denotes	]
T4459	27011-27012	.	denotes	.
T4460	27012-27163	sentence	denotes	Similarly, the effects of various factors including age, gender, blood pressure, obesity and diabetes have been variably associated with elevated IOP.
T4461	27013-27022	RB	denotes	Similarly
T4463	27022-27024	,	denotes	,
T4464	27024-27027	DT	denotes	the
T4465	27028-27035	NNS	denotes	effects
T4466	27036-27038	IN	denotes	of
T4467	27039-27046	JJ	denotes	various
T4468	27047-27054	NNS	denotes	factors
T4469	27055-27064	VBG	denotes	including
T4470	27065-27068	NN	denotes	age
T4471	27068-27070	,	denotes	,
T4472	27070-27076	NN	denotes	gender
T4473	27076-27078	,	denotes	,
T4474	27078-27083	NN	denotes	blood
T4475	27084-27092	NN	denotes	pressure
T4476	27092-27094	,	denotes	,
T4477	27094-27101	NN	denotes	obesity
T4478	27102-27105	CC	denotes	and
T4479	27106-27114	NN	denotes	diabetes
T4480	27115-27119	VBP	denotes	have
T4481	27120-27124	VBN	denotes	been
T4482	27125-27133	RB	denotes	variably
T4462	27134-27144	VBN	denotes	associated
T4483	27145-27149	IN	denotes	with
T4484	27150-27158	JJ	denotes	elevated
T4485	27159-27162	NNP	denotes	IOP
T4486	27162-27163	.	denotes	.
T4487	27163-27300	sentence	denotes	We evaluated the relationship between these latter factors and IOP in genetically homogeneous mouse strains in a controlled environment.
T4488	27164-27166	PRP	denotes	We
T4489	27167-27176	VBD	denotes	evaluated
T4490	27177-27180	DT	denotes	the
T4491	27181-27193	NN	denotes	relationship
T4492	27194-27201	IN	denotes	between
T4493	27202-27207	DT	denotes	these
T4495	27208-27214	JJ	denotes	latter
T4494	27215-27222	NNS	denotes	factors
T4496	27223-27226	CC	denotes	and
T4497	27227-27230	NN	denotes	IOP
T4498	27231-27233	IN	denotes	in
T4499	27234-27245	RB	denotes	genetically
T4500	27246-27257	JJ	denotes	homogeneous
T4502	27258-27263	NN	denotes	mouse
T4501	27264-27271	NNS	denotes	strains
T4503	27272-27274	IN	denotes	in
T4504	27275-27276	DT	denotes	a
T4506	27277-27287	VBN	denotes	controlled
T4505	27288-27299	NN	denotes	environment
T4507	27299-27300	.	denotes	.
T4508	27300-27305	sentence	denotes	Age
T4509	27302-27305	NNP	denotes	Age
T4510	27305-27430	sentence	denotes	Although within the range of variability observed in young mice, the IOP of B6 mice modestly decreased around 1 year of age.
T4511	27306-27314	IN	denotes	Although
T4512	27315-27321	IN	denotes	within
T4514	27322-27325	DT	denotes	the
T4515	27326-27331	NN	denotes	range
T4516	27332-27334	IN	denotes	of
T4517	27335-27346	NN	denotes	variability
T4518	27347-27355	VBN	denotes	observed
T4519	27356-27358	IN	denotes	in
T4520	27359-27364	JJ	denotes	young
T4521	27365-27369	NNS	denotes	mice
T4522	27369-27371	,	denotes	,
T4523	27371-27374	DT	denotes	the
T4524	27375-27378	NN	denotes	IOP
T4525	27379-27381	IN	denotes	of
T4526	27382-27384	NN	denotes	B6
T4527	27385-27389	NNS	denotes	mice
T4528	27390-27398	RB	denotes	modestly
T4513	27399-27408	VBD	denotes	decreased
T4529	27409-27415	IN	denotes	around
T4530	27416-27417	CD	denotes	1
T4531	27418-27422	NN	denotes	year
T4532	27423-27425	IN	denotes	of
T4533	27426-27429	NN	denotes	age
T4534	27429-27430	.	denotes	.
T4535	27430-27524	sentence	denotes	This decrease was statistically significant compared to young mice measured at the same time.
T4536	27431-27435	DT	denotes	This
T4537	27436-27444	NN	denotes	decrease
T4538	27445-27448	VBD	denotes	was
T4539	27449-27462	RB	denotes	statistically
T4540	27463-27474	JJ	denotes	significant
T4541	27475-27483	VBN	denotes	compared
T4542	27484-27486	IN	denotes	to
T4543	27487-27492	JJ	denotes	young
T4544	27493-27497	NNS	denotes	mice
T4545	27498-27506	VBN	denotes	measured
T4546	27507-27509	IN	denotes	at
T4547	27510-27513	DT	denotes	the
T4549	27514-27518	JJ	denotes	same
T4548	27519-27523	NN	denotes	time
T4550	27523-27524	.	denotes	.
T4551	27524-27664	sentence	denotes	At 2 years of age the IOP of B6 mice had decreased further, though an effect of anesthesia in these very old mice cannot be ruled out [49].
T4552	27525-27527	IN	denotes	At
T4554	27528-27529	CD	denotes	2
T4555	27530-27535	NNS	denotes	years
T4556	27536-27538	IN	denotes	of
T4557	27539-27542	NN	denotes	age
T4558	27543-27546	DT	denotes	the
T4559	27547-27550	NN	denotes	IOP
T4560	27551-27553	IN	denotes	of
T4561	27554-27556	NN	denotes	B6
T4562	27557-27561	NNS	denotes	mice
T4563	27562-27565	VBD	denotes	had
T4553	27566-27575	VBN	denotes	decreased
T4564	27576-27583	RBR	denotes	further
T4565	27583-27585	,	denotes	,
T4566	27585-27591	IN	denotes	though
T4568	27592-27594	DT	denotes	an
T4569	27595-27601	NN	denotes	effect
T4570	27602-27604	IN	denotes	of
T4571	27605-27615	NN	denotes	anesthesia
T4572	27616-27618	IN	denotes	in
T4573	27619-27624	DT	denotes	these
T4575	27625-27629	RB	denotes	very
T4576	27630-27633	JJ	denotes	old
T4574	27634-27638	NNS	denotes	mice
T4577	27639-27642	MD	denotes	can
T4578	27642-27645	RB	denotes	not
T4579	27646-27648	VB	denotes	be
T4567	27649-27654	VBN	denotes	ruled
T4580	27655-27658	RP	denotes	out
T4581	27659-27660	-LRB-	denotes	[
T4582	27660-27662	CD	denotes	49
T4583	27662-27663	-RRB-	denotes	]
T4584	27663-27664	.	denotes	.
T4585	27664-27761	sentence	denotes	The IOP of 129P3/J mice also decreased with age but only at the oldest age examined (18 months).
T4586	27665-27668	DT	denotes	The
T4587	27669-27672	NN	denotes	IOP
T4589	27673-27675	IN	denotes	of
T4590	27676-27681	NN	denotes	129P3
T4592	27681-27682	HYPH	denotes	/
T4591	27682-27683	NN	denotes	J
T4593	27684-27688	NNS	denotes	mice
T4594	27689-27693	RB	denotes	also
T4588	27694-27703	VBD	denotes	decreased
T4595	27704-27708	IN	denotes	with
T4596	27709-27712	NN	denotes	age
T4597	27713-27716	CC	denotes	but
T4598	27717-27721	RB	denotes	only
T4599	27722-27724	IN	denotes	at
T4600	27725-27728	DT	denotes	the
T4602	27729-27735	JJS	denotes	oldest
T4601	27736-27739	NN	denotes	age
T4603	27740-27748	VBN	denotes	examined
T4604	27749-27750	-LRB-	denotes	(
T4605	27750-27752	CD	denotes	18
T4606	27753-27759	NNS	denotes	months
T4607	27759-27760	-RRB-	denotes	)
T4608	27760-27761	.	denotes	.
T4609	27761-27849	sentence	denotes	Decreasing IOP correlates with increasing age in the human Japanese population [50,51].
T4610	27762-27772	VBG	denotes	Decreasing
T4611	27773-27776	NN	denotes	IOP
T4612	27777-27787	VBZ	denotes	correlates
T4613	27788-27792	IN	denotes	with
T4614	27793-27803	VBG	denotes	increasing
T4615	27804-27807	NN	denotes	age
T4616	27808-27810	IN	denotes	in
T4617	27811-27814	DT	denotes	the
T4619	27815-27820	JJ	denotes	human
T4620	27821-27829	JJ	denotes	Japanese
T4618	27830-27840	NN	denotes	population
T4621	27841-27842	-LRB-	denotes	[
T4623	27842-27844	CD	denotes	50
T4624	27844-27845	,	denotes	,
T4622	27845-27847	CD	denotes	51
T4625	27847-27848	-RRB-	denotes	]
T4626	27848-27849	.	denotes	.
T4627	27849-27929	sentence	denotes	Further studies of B6 mice may allow experimental investigation of this effect.
T4628	27850-27857	JJ	denotes	Further
T4629	27858-27865	NNS	denotes	studies
T4631	27866-27868	IN	denotes	of
T4632	27869-27871	NN	denotes	B6
T4633	27872-27876	NNS	denotes	mice
T4634	27877-27880	MD	denotes	may
T4630	27881-27886	VB	denotes	allow
T4635	27887-27899	JJ	denotes	experimental
T4636	27900-27913	NN	denotes	investigation
T4637	27914-27916	IN	denotes	of
T4638	27917-27921	DT	denotes	this
T4639	27922-27928	NN	denotes	effect
T4640	27928-27929	.	denotes	.
T4641	27929-28078	sentence	denotes	Additional studies may also identify " normal" mouse strains that develop increased IOP with age as generally occurs in Western populations [52,53].
T4642	27930-27940	JJ	denotes	Additional
T4643	27941-27948	NNS	denotes	studies
T4645	27949-27952	MD	denotes	may
T4646	27953-27957	RB	denotes	also
T4644	27958-27966	VB	denotes	identify
T4647	27967-27968	``	denotes	"
T4648	27969-27975	JJ	denotes	normal
T4650	27975-27976	''	denotes	"
T4651	27977-27982	NN	denotes	mouse
T4649	27983-27990	NNS	denotes	strains
T4652	27991-27995	WDT	denotes	that
T4653	27996-28003	VBP	denotes	develop
T4654	28004-28013	VBN	denotes	increased
T4655	28014-28017	NN	denotes	IOP
T4656	28018-28022	IN	denotes	with
T4657	28023-28026	NN	denotes	age
T4658	28027-28029	IN	denotes	as
T4660	28030-28039	RB	denotes	generally
T4659	28040-28046	VBZ	denotes	occurs
T4661	28047-28049	IN	denotes	in
T4662	28050-28057	JJ	denotes	Western
T4663	28058-28069	NNS	denotes	populations
T4664	28070-28071	-LRB-	denotes	[
T4666	28071-28073	CD	denotes	52
T4667	28073-28074	,	denotes	,
T4665	28074-28076	CD	denotes	53
T4668	28076-28077	-RRB-	denotes	]
T4669	28077-28078	.	denotes	.
T4670	28078-28196	sentence	denotes	We previously demonstrated that the glaucomatous strains DBA/2J and AKXD-28/Ty develop elevated IOP with age [14,19].
T4671	28079-28081	PRP	denotes	We
T4673	28082-28092	RB	denotes	previously
T4672	28093-28105	VBD	denotes	demonstrated
T4674	28106-28110	IN	denotes	that
T4676	28111-28114	DT	denotes	the
T4678	28115-28127	JJ	denotes	glaucomatous
T4679	28128-28135	NNS	denotes	strains
T4680	28136-28139	NN	denotes	DBA
T4681	28139-28140	HYPH	denotes	/
T4677	28140-28142	NN	denotes	2J
T4682	28143-28146	CC	denotes	and
T4683	28147-28151	NN	denotes	AKXD
T4685	28151-28152	HYPH	denotes	-
T4686	28152-28154	NN	denotes	28
T4687	28154-28155	HYPH	denotes	/
T4684	28155-28157	NN	denotes	Ty
T4675	28158-28165	VBP	denotes	develop
T4688	28166-28174	JJ	denotes	elevated
T4689	28175-28178	NN	denotes	IOP
T4690	28179-28183	IN	denotes	with
T4691	28184-28187	NN	denotes	age
T4692	28188-28189	-LRB-	denotes	[
T4694	28189-28191	CD	denotes	14
T4695	28191-28192	,	denotes	,
T4693	28192-28194	CD	denotes	19
T4696	28194-28195	-RRB-	denotes	]
T4697	28195-28196	.	denotes	.
T4698	28196-28204	sentence	denotes	Gender
T4699	28198-28204	NN	denotes	Gender
T4700	28204-28298	sentence	denotes	In the examined strains, we found no consistent differences in IOP between males and females.
T4701	28205-28207	IN	denotes	In
T4703	28208-28211	DT	denotes	the
T4705	28212-28220	VBN	denotes	examined
T4704	28221-28228	NNS	denotes	strains
T4706	28228-28230	,	denotes	,
T4707	28230-28232	PRP	denotes	we
T4702	28233-28238	VBD	denotes	found
T4708	28239-28241	DT	denotes	no
T4710	28242-28252	JJ	denotes	consistent
T4709	28253-28264	NNS	denotes	differences
T4711	28265-28267	IN	denotes	in
T4712	28268-28271	NN	denotes	IOP
T4713	28272-28279	IN	denotes	between
T4714	28280-28285	NNS	denotes	males
T4715	28286-28289	CC	denotes	and
T4716	28290-28297	NNS	denotes	females
T4717	28297-28298	.	denotes	.
T4718	28298-28380	sentence	denotes	This was true at all ages for the 3 strains that were aged to 18 months or older.
T4719	28299-28303	DT	denotes	This
T4720	28304-28307	VBD	denotes	was
T4721	28308-28312	JJ	denotes	true
T4722	28313-28315	IN	denotes	at
T4723	28316-28319	DT	denotes	all
T4724	28320-28324	NNS	denotes	ages
T4725	28325-28328	IN	denotes	for
T4726	28329-28332	DT	denotes	the
T4728	28333-28334	CD	denotes	3
T4727	28335-28342	NNS	denotes	strains
T4729	28343-28347	WDT	denotes	that
T4731	28348-28352	VBD	denotes	were
T4730	28353-28357	VBN	denotes	aged
T4732	28358-28360	IN	denotes	to
T4733	28361-28363	CD	denotes	18
T4734	28364-28370	NNS	denotes	months
T4735	28371-28373	CC	denotes	or
T4736	28374-28379	JJR	denotes	older
T4737	28379-28380	.	denotes	.
T4738	28380-28489	sentence	denotes	This is in agreement with a number of human studies, which show that IOP is equal between the sexes [52,53].
T4739	28381-28385	DT	denotes	This
T4740	28386-28388	VBZ	denotes	is
T4741	28389-28391	IN	denotes	in
T4742	28392-28401	NN	denotes	agreement
T4743	28402-28406	IN	denotes	with
T4744	28407-28408	DT	denotes	a
T4745	28409-28415	NN	denotes	number
T4746	28416-28418	IN	denotes	of
T4747	28419-28424	JJ	denotes	human
T4748	28425-28432	NNS	denotes	studies
T4749	28432-28434	,	denotes	,
T4750	28434-28439	WDT	denotes	which
T4751	28440-28444	VBP	denotes	show
T4752	28445-28449	IN	denotes	that
T4754	28450-28453	NN	denotes	IOP
T4753	28454-28456	VBZ	denotes	is
T4755	28457-28462	JJ	denotes	equal
T4756	28463-28470	IN	denotes	between
T4757	28471-28474	DT	denotes	the
T4758	28475-28480	NNS	denotes	sexes
T4759	28481-28482	-LRB-	denotes	[
T4761	28482-28484	CD	denotes	52
T4762	28484-28485	,	denotes	,
T4760	28485-28487	CD	denotes	53
T4763	28487-28488	-RRB-	denotes	]
T4764	28488-28489	.	denotes	.
T4765	28489-28664	sentence	denotes	However, some studies have found sex-specific differences (typically with higher IOP in females and the magnitude of the difference increasing after 40 years of age) [53,54].
T4766	28490-28497	RB	denotes	However
T4768	28497-28499	,	denotes	,
T4769	28499-28503	DT	denotes	some
T4770	28504-28511	NNS	denotes	studies
T4771	28512-28516	VBP	denotes	have
T4767	28517-28522	VBN	denotes	found
T4772	28523-28526	NN	denotes	sex
T4774	28526-28527	HYPH	denotes	-
T4773	28527-28535	JJ	denotes	specific
T4775	28536-28547	NNS	denotes	differences
T4776	28548-28549	-LRB-	denotes	(
T4777	28549-28558	RB	denotes	typically
T4778	28559-28563	IN	denotes	with
T4779	28564-28570	JJR	denotes	higher
T4780	28571-28574	NN	denotes	IOP
T4781	28575-28577	IN	denotes	in
T4782	28578-28585	NNS	denotes	females
T4783	28586-28589	CC	denotes	and
T4784	28590-28593	DT	denotes	the
T4785	28594-28603	NN	denotes	magnitude
T4787	28604-28606	IN	denotes	of
T4788	28607-28610	DT	denotes	the
T4789	28611-28621	NN	denotes	difference
T4786	28622-28632	VBG	denotes	increasing
T4790	28633-28638	IN	denotes	after
T4791	28639-28641	CD	denotes	40
T4792	28642-28647	NNS	denotes	years
T4793	28648-28650	IN	denotes	of
T4794	28651-28654	NN	denotes	age
T4795	28654-28655	-RRB-	denotes	)
T4796	28656-28657	-LRB-	denotes	[
T4798	28657-28659	CD	denotes	53
T4799	28659-28660	,	denotes	,
T4797	28660-28662	CD	denotes	54
T4800	28662-28663	-RRB-	denotes	]
T4801	28663-28664	.	denotes	.
T4802	28664-28819	sentence	denotes	Of possible relevance, we previously reported that female mice of strains DBA/2J and AKXD-28/Ty develop elevated IOP at an earlier age than males [14,19].
T4803	28665-28667	IN	denotes	Of
T4805	28668-28676	JJ	denotes	possible
T4806	28677-28686	NN	denotes	relevance
T4807	28686-28688	,	denotes	,
T4808	28688-28690	PRP	denotes	we
T4809	28691-28701	RB	denotes	previously
T4804	28702-28710	VBD	denotes	reported
T4810	28711-28715	IN	denotes	that
T4812	28716-28722	JJ	denotes	female
T4813	28723-28727	NNS	denotes	mice
T4814	28728-28730	IN	denotes	of
T4815	28731-28738	NNS	denotes	strains
T4817	28739-28742	NN	denotes	DBA
T4818	28742-28743	HYPH	denotes	/
T4816	28743-28745	NN	denotes	2J
T4819	28746-28749	CC	denotes	and
T4820	28750-28754	NN	denotes	AKXD
T4822	28754-28755	HYPH	denotes	-
T4823	28755-28757	NN	denotes	28
T4824	28757-28758	HYPH	denotes	/
T4821	28758-28760	NN	denotes	Ty
T4811	28761-28768	VBP	denotes	develop
T4825	28769-28777	JJ	denotes	elevated
T4826	28778-28781	NN	denotes	IOP
T4827	28782-28784	IN	denotes	at
T4828	28785-28787	DT	denotes	an
T4830	28788-28795	JJR	denotes	earlier
T4829	28796-28799	NN	denotes	age
T4831	28800-28804	IN	denotes	than
T4832	28805-28810	NNS	denotes	males
T4833	28811-28812	-LRB-	denotes	[
T4835	28812-28814	CD	denotes	14
T4836	28814-28815	,	denotes	,
T4834	28815-28817	CD	denotes	19
T4837	28817-28818	-RRB-	denotes	]
T4838	28818-28819	.	denotes	.
T4839	28819-28835	sentence	denotes	Blood pressure
T4840	28821-28826	NN	denotes	Blood
T4841	28827-28835	NN	denotes	pressure
T4842	28835-28943	sentence	denotes	Some but not all human studies have reported a positive association between IOP and blood pressure [48,52].
T4843	28836-28840	DT	denotes	Some
T4845	28841-28844	CC	denotes	but
T4846	28845-28848	RB	denotes	not
T4847	28849-28852	DT	denotes	all
T4849	28853-28858	JJ	denotes	human
T4848	28859-28866	NNS	denotes	studies
T4850	28867-28871	VBP	denotes	have
T4844	28872-28880	VBN	denotes	reported
T4851	28881-28882	DT	denotes	a
T4853	28883-28891	JJ	denotes	positive
T4852	28892-28903	NN	denotes	association
T4854	28904-28911	IN	denotes	between
T4855	28912-28915	NN	denotes	IOP
T4856	28916-28919	CC	denotes	and
T4857	28920-28925	NN	denotes	blood
T4858	28926-28934	NN	denotes	pressure
T4859	28935-28936	-LRB-	denotes	[
T4861	28936-28938	CD	denotes	48
T4862	28938-28939	,	denotes	,
T4860	28939-28941	CD	denotes	52
T4863	28941-28942	-RRB-	denotes	]
T4864	28942-28943	.	denotes	.
T4865	28943-29150	sentence	denotes	Our comparison of the relationship between blood pressure and IOP in young, adult female mice of different mouse strains, whose blood pressures differed up to 36 mmHg, did not reveal a positive correlation.
T4866	28944-28947	PRP$	denotes	Our
T4867	28948-28958	NN	denotes	comparison
T4869	28959-28961	IN	denotes	of
T4870	28962-28965	DT	denotes	the
T4871	28966-28978	NN	denotes	relationship
T4872	28979-28986	IN	denotes	between
T4873	28987-28992	NN	denotes	blood
T4874	28993-29001	NN	denotes	pressure
T4875	29002-29005	CC	denotes	and
T4876	29006-29009	NN	denotes	IOP
T4877	29010-29012	IN	denotes	in
T4878	29013-29018	JJ	denotes	young
T4880	29018-29020	,	denotes	,
T4881	29020-29025	JJ	denotes	adult
T4882	29026-29032	JJ	denotes	female
T4879	29033-29037	NNS	denotes	mice
T4883	29038-29040	IN	denotes	of
T4884	29041-29050	JJ	denotes	different
T4886	29051-29056	NN	denotes	mouse
T4885	29057-29064	NNS	denotes	strains
T4887	29064-29066	,	denotes	,
T4888	29066-29071	WP$	denotes	whose
T4890	29072-29077	NN	denotes	blood
T4889	29078-29087	NNS	denotes	pressures
T4891	29088-29096	VBD	denotes	differed
T4892	29097-29099	RB	denotes	up
T4894	29100-29102	IN	denotes	to
T4893	29103-29105	CD	denotes	36
T4895	29106-29110	NN	denotes	mmHg
T4896	29110-29112	,	denotes	,
T4897	29112-29115	VBD	denotes	did
T4898	29116-29119	RB	denotes	not
T4868	29120-29126	VB	denotes	reveal
T4899	29127-29128	DT	denotes	a
T4901	29129-29137	JJ	denotes	positive
T4900	29138-29149	NN	denotes	correlation
T4902	29149-29150	.	denotes	.
T4903	29150-29338	sentence	denotes	Further studies are needed to determine if blood pressure correlates with IOP in males, and to determine the relationship between blood pressure and IOP in various mouse strains with age.
T4904	29151-29158	JJ	denotes	Further
T4905	29159-29166	NNS	denotes	studies
T4907	29167-29170	VBP	denotes	are
T4906	29171-29177	VBN	denotes	needed
T4908	29178-29180	TO	denotes	to
T4909	29181-29190	VB	denotes	determine
T4910	29191-29193	IN	denotes	if
T4912	29194-29199	NN	denotes	blood
T4913	29200-29208	NN	denotes	pressure
T4911	29209-29219	VBZ	denotes	correlates
T4914	29220-29224	IN	denotes	with
T4915	29225-29228	NN	denotes	IOP
T4916	29229-29231	IN	denotes	in
T4917	29232-29237	NNS	denotes	males
T4918	29237-29239	,	denotes	,
T4919	29239-29242	CC	denotes	and
T4920	29243-29245	TO	denotes	to
T4921	29246-29255	VB	denotes	determine
T4922	29256-29259	DT	denotes	the
T4923	29260-29272	NN	denotes	relationship
T4924	29273-29280	IN	denotes	between
T4925	29281-29286	NN	denotes	blood
T4926	29287-29295	NN	denotes	pressure
T4927	29296-29299	CC	denotes	and
T4928	29300-29303	NN	denotes	IOP
T4929	29304-29306	IN	denotes	in
T4930	29307-29314	JJ	denotes	various
T4932	29315-29320	NN	denotes	mouse
T4931	29321-29328	NNS	denotes	strains
T4933	29329-29333	IN	denotes	with
T4934	29334-29337	NN	denotes	age
T4935	29337-29338	.	denotes	.
T4936	29338-29360	sentence	denotes	Obesity and diabetes
T4937	29340-29347	NN	denotes	Obesity
T4938	29348-29351	CC	denotes	and
T4939	29352-29360	NN	denotes	diabetes
T4940	29360-29504	sentence	denotes	Obesity or higher body mass index have been implicated by some but not other studies as risk factors for increased IOP and glaucoma [51,55-57].
T4941	29361-29368	NN	denotes	Obesity
T4943	29369-29371	CC	denotes	or
T4944	29372-29378	JJR	denotes	higher
T4946	29379-29383	NN	denotes	body
T4947	29384-29388	NN	denotes	mass
T4945	29389-29394	NN	denotes	index
T4948	29395-29399	VBP	denotes	have
T4949	29400-29404	VBN	denotes	been
T4942	29405-29415	VBN	denotes	implicated
T4950	29416-29418	IN	denotes	by
T4951	29419-29423	DT	denotes	some
T4953	29424-29427	CC	denotes	but
T4954	29428-29431	RB	denotes	not
T4955	29432-29437	JJ	denotes	other
T4952	29438-29445	NNS	denotes	studies
T4956	29446-29448	IN	denotes	as
T4957	29449-29453	NN	denotes	risk
T4958	29454-29461	NNS	denotes	factors
T4959	29462-29465	IN	denotes	for
T4960	29466-29475	VBN	denotes	increased
T4961	29476-29479	NN	denotes	IOP
T4962	29480-29483	CC	denotes	and
T4963	29484-29492	NN	denotes	glaucoma
T4964	29493-29494	-LRB-	denotes	[
T4966	29494-29496	CD	denotes	51
T4967	29496-29497	,	denotes	,
T4968	29497-29499	CD	denotes	55
T4969	29499-29500	HYPH	denotes	-
T4965	29500-29502	CD	denotes	57
T4970	29502-29503	-RRB-	denotes	]
T4971	29503-29504	.	denotes	.
T4972	29504-29643	sentence	denotes	Similarly, diabetes or the combination of diabetes and obesity have been variably associated with elevated IOP and glaucoma [46,52,58-62].
T4973	29505-29514	RB	denotes	Similarly
T4975	29514-29516	,	denotes	,
T4976	29516-29524	NN	denotes	diabetes
T4977	29525-29527	CC	denotes	or
T4978	29528-29531	DT	denotes	the
T4979	29532-29543	NN	denotes	combination
T4980	29544-29546	IN	denotes	of
T4981	29547-29555	NN	denotes	diabetes
T4982	29556-29559	CC	denotes	and
T4983	29560-29567	NN	denotes	obesity
T4984	29568-29572	VBP	denotes	have
T4985	29573-29577	VBN	denotes	been
T4986	29578-29586	RB	denotes	variably
T4974	29587-29597	VBN	denotes	associated
T4987	29598-29602	IN	denotes	with
T4988	29603-29611	JJ	denotes	elevated
T4989	29612-29615	NN	denotes	IOP
T4990	29616-29619	CC	denotes	and
T4991	29620-29628	NN	denotes	glaucoma
T4992	29629-29630	-LRB-	denotes	[
T4993	29630-29632	CD	denotes	46
T4994	29632-29633	,	denotes	,
T4995	29633-29635	CD	denotes	52
T4996	29635-29636	,	denotes	,
T4997	29636-29638	CD	denotes	58
T4998	29638-29639	SYM	denotes	-
T4999	29639-29641	CD	denotes	62
T5000	29641-29642	-RRB-	denotes	]
T5001	29642-29643	.	denotes	.
T5002	29643-29922	sentence	denotes	To test if genetic perturbations that cause obesity and diabetes can alter IOP, we compared groups of mice that were genetically similar except that they were either homozygous or heterozygous for a leptin receptor mutation (db) that results in early onset obesity and diabetes.
T5003	29644-29646	TO	denotes	To
T5004	29647-29651	VB	denotes	test
T5006	29652-29654	IN	denotes	if
T5008	29655-29662	JJ	denotes	genetic
T5009	29663-29676	NNS	denotes	perturbations
T5010	29677-29681	WDT	denotes	that
T5011	29682-29687	VBP	denotes	cause
T5012	29688-29695	NN	denotes	obesity
T5013	29696-29699	CC	denotes	and
T5014	29700-29708	NN	denotes	diabetes
T5015	29709-29712	MD	denotes	can
T5007	29713-29718	VB	denotes	alter
T5016	29719-29722	NNP	denotes	IOP
T5017	29722-29724	,	denotes	,
T5018	29724-29726	PRP	denotes	we
T5005	29727-29735	VBD	denotes	compared
T5019	29736-29742	NNS	denotes	groups
T5020	29743-29745	IN	denotes	of
T5021	29746-29750	NNS	denotes	mice
T5022	29751-29755	WDT	denotes	that
T5023	29756-29760	VBD	denotes	were
T5024	29761-29772	RB	denotes	genetically
T5025	29773-29780	JJ	denotes	similar
T5026	29781-29787	IN	denotes	except
T5027	29788-29792	IN	denotes	that
T5029	29793-29797	PRP	denotes	they
T5028	29798-29802	VBD	denotes	were
T5030	29803-29809	CC	denotes	either
T5031	29810-29820	JJ	denotes	homozygous
T5032	29821-29823	CC	denotes	or
T5033	29824-29836	JJ	denotes	heterozygous
T5034	29837-29840	IN	denotes	for
T5035	29841-29842	DT	denotes	a
T5037	29843-29849	NN	denotes	leptin
T5038	29850-29858	NN	denotes	receptor
T5036	29859-29867	NN	denotes	mutation
T5039	29868-29869	-LRB-	denotes	(
T5040	29869-29871	NN	denotes	db
T5041	29871-29872	-RRB-	denotes	)
T5042	29873-29877	WDT	denotes	that
T5043	29878-29885	VBZ	denotes	results
T5044	29886-29888	IN	denotes	in
T5045	29889-29894	JJ	denotes	early
T5046	29895-29900	NN	denotes	onset
T5047	29901-29908	NN	denotes	obesity
T5048	29909-29912	CC	denotes	and
T5049	29913-29921	NN	denotes	diabetes
T5050	29921-29922	.	denotes	.
T5051	29922-30006	sentence	denotes	The obese, diabetic mice had higher IOPs than their lean, non-diabetic littermates.
T5052	29923-29926	DT	denotes	The
T5054	29927-29932	JJ	denotes	obese
T5055	29932-29934	,	denotes	,
T5056	29934-29942	JJ	denotes	diabetic
T5053	29943-29947	NNS	denotes	mice
T5057	29948-29951	VBD	denotes	had
T5058	29952-29958	JJR	denotes	higher
T5059	29959-29963	NNS	denotes	IOPs
T5060	29964-29968	IN	denotes	than
T5061	29969-29974	PRP$	denotes	their
T5063	29975-29979	JJ	denotes	lean
T5064	29979-29981	,	denotes	,
T5065	29981-29993	JJ	denotes	non-diabetic
T5062	29994-30005	NNS	denotes	littermates
T5066	30005-30006	.	denotes	.
T5067	30006-30154	sentence	denotes	Thus, epidemiological associations between increased IOP and obesity or diabetes are supported by this work and appear to be functionally relevant.
T5068	30007-30011	RB	denotes	Thus
T5070	30011-30013	,	denotes	,
T5071	30013-30028	JJ	denotes	epidemiological
T5072	30029-30041	NNS	denotes	associations
T5073	30042-30049	IN	denotes	between
T5074	30050-30059	VBN	denotes	increased
T5075	30060-30063	NN	denotes	IOP
T5076	30064-30067	CC	denotes	and
T5077	30068-30075	NN	denotes	obesity
T5078	30076-30078	CC	denotes	or
T5079	30079-30087	NN	denotes	diabetes
T5080	30088-30091	VBP	denotes	are
T5069	30092-30101	VBN	denotes	supported
T5081	30102-30104	IN	denotes	by
T5082	30105-30109	DT	denotes	this
T5083	30110-30114	NN	denotes	work
T5084	30115-30118	CC	denotes	and
T5085	30119-30125	VBP	denotes	appear
T5086	30126-30128	TO	denotes	to
T5087	30129-30131	VB	denotes	be
T5088	30132-30144	RB	denotes	functionally
T5089	30145-30153	JJ	denotes	relevant
T5090	30153-30154	.	denotes	.
T5091	30154-30295	sentence	denotes	Further experiments with obese non-diabetic or diabetic non-obese mice will help to characterize the separate effects of these risk factors.
T5092	30155-30162	JJR	denotes	Further
T5093	30163-30174	NNS	denotes	experiments
T5095	30175-30179	IN	denotes	with
T5096	30180-30185	JJ	denotes	obese
T5097	30186-30198	JJ	denotes	non-diabetic
T5099	30199-30201	CC	denotes	or
T5100	30202-30210	JJ	denotes	diabetic
T5101	30211-30220	JJ	denotes	non-obese
T5098	30221-30225	NNS	denotes	mice
T5102	30226-30230	MD	denotes	will
T5094	30231-30235	VB	denotes	help
T5103	30236-30238	TO	denotes	to
T5104	30239-30251	VB	denotes	characterize
T5105	30252-30255	DT	denotes	the
T5107	30256-30264	JJ	denotes	separate
T5106	30265-30272	NNS	denotes	effects
T5108	30273-30275	IN	denotes	of
T5109	30276-30281	DT	denotes	these
T5111	30282-30286	NN	denotes	risk
T5110	30287-30294	NNS	denotes	factors
T5112	30294-30295	.	denotes	.
T5222	30297-30300	NN	denotes	IOP
T5224	30301-30303	VBZ	denotes	is
T5223	30304-30313	VBN	denotes	increased
T5225	30314-30320	IN	denotes	during
T5226	30321-30324	DT	denotes	the
T5228	30325-30329	JJ	denotes	dark
T5227	30330-30336	NN	denotes	period
T5229	30337-30339	IN	denotes	of
T5230	30340-30343	DT	denotes	the
T5231	30344-30347	NN	denotes	day
T5232	30347-30421	sentence	denotes	Diurnal variation in IOP is common in humans and laboratory animals [53].
T5233	30348-30355	JJ	denotes	Diurnal
T5234	30356-30365	NN	denotes	variation
T5236	30366-30368	IN	denotes	in
T5237	30369-30372	NN	denotes	IOP
T5235	30373-30375	VBZ	denotes	is
T5238	30376-30382	JJ	denotes	common
T5239	30383-30385	IN	denotes	in
T5240	30386-30392	NNS	denotes	humans
T5241	30393-30396	CC	denotes	and
T5242	30397-30407	NN	denotes	laboratory
T5243	30408-30415	NNS	denotes	animals
T5244	30416-30417	-LRB-	denotes	[
T5245	30417-30419	CD	denotes	53
T5246	30419-30420	-RRB-	denotes	]
T5247	30420-30421	.	denotes	.
T5248	30421-30617	sentence	denotes	The molecular mechanisms underlying the diurnal rhythm are not defined but increased aqueous humor production or flow occurs during the period of increased IOP in both rabbits and humans [63-65].
T5249	30422-30425	DT	denotes	The
T5251	30426-30435	JJ	denotes	molecular
T5250	30436-30446	NNS	denotes	mechanisms
T5253	30447-30457	VBG	denotes	underlying
T5254	30458-30461	DT	denotes	the
T5256	30462-30469	JJ	denotes	diurnal
T5255	30470-30476	NN	denotes	rhythm
T5257	30477-30480	VBP	denotes	are
T5258	30481-30484	RB	denotes	not
T5252	30485-30492	VBN	denotes	defined
T5259	30493-30496	CC	denotes	but
T5260	30497-30506	VBN	denotes	increased
T5262	30507-30514	JJ	denotes	aqueous
T5261	30515-30520	NN	denotes	humor
T5264	30521-30531	NN	denotes	production
T5265	30532-30534	CC	denotes	or
T5266	30535-30539	NN	denotes	flow
T5263	30540-30546	VBZ	denotes	occurs
T5267	30547-30553	IN	denotes	during
T5268	30554-30557	DT	denotes	the
T5269	30558-30564	NN	denotes	period
T5270	30565-30567	IN	denotes	of
T5271	30568-30577	VBN	denotes	increased
T5272	30578-30581	NN	denotes	IOP
T5273	30582-30584	IN	denotes	in
T5274	30585-30589	CC	denotes	both
T5275	30590-30597	NNS	denotes	rabbits
T5276	30598-30601	CC	denotes	and
T5277	30602-30608	NNS	denotes	humans
T5278	30609-30610	-LRB-	denotes	[
T5279	30610-30612	CD	denotes	63
T5280	30612-30613	SYM	denotes	-
T5281	30613-30615	CD	denotes	65
T5282	30615-30616	-RRB-	denotes	]
T5283	30616-30617	.	denotes	.
T5284	30617-30734	sentence	denotes	Small changes in the resistance to aqueous humor drainage may also contribute to diurnal differences in IOP [66,67].
T5285	30618-30623	JJ	denotes	Small
T5286	30624-30631	NNS	denotes	changes
T5288	30632-30634	IN	denotes	in
T5289	30635-30638	DT	denotes	the
T5290	30639-30649	NN	denotes	resistance
T5291	30650-30652	IN	denotes	to
T5292	30653-30660	JJ	denotes	aqueous
T5294	30661-30666	NN	denotes	humor
T5293	30667-30675	NN	denotes	drainage
T5295	30676-30679	MD	denotes	may
T5296	30680-30684	RB	denotes	also
T5287	30685-30695	VB	denotes	contribute
T5297	30696-30698	IN	denotes	to
T5298	30699-30706	JJ	denotes	diurnal
T5299	30707-30718	NNS	denotes	differences
T5300	30719-30721	IN	denotes	in
T5301	30722-30725	NN	denotes	IOP
T5302	30726-30727	-LRB-	denotes	[
T5304	30727-30729	CD	denotes	66
T5305	30729-30730	,	denotes	,
T5303	30730-30732	CD	denotes	67
T5306	30732-30733	-RRB-	denotes	]
T5307	30733-30734	.	denotes	.
T5308	30734-30922	sentence	denotes	We first suspected IOP changes with time of day when the IOP of a group of B6 mice measured in the hour prior to onset of the dark period appeared to be higher than at other times of day.
T5309	30735-30737	PRP	denotes	We
T5311	30738-30743	RB	denotes	first
T5310	30744-30753	VBD	denotes	suspected
T5312	30754-30757	NN	denotes	IOP
T5313	30758-30765	VBZ	denotes	changes
T5314	30766-30770	IN	denotes	with
T5315	30771-30775	NN	denotes	time
T5316	30776-30778	IN	denotes	of
T5317	30779-30782	NN	denotes	day
T5318	30783-30787	WRB	denotes	when
T5320	30788-30791	DT	denotes	the
T5321	30792-30795	NN	denotes	IOP
T5322	30796-30798	IN	denotes	of
T5323	30799-30800	DT	denotes	a
T5324	30801-30806	NN	denotes	group
T5325	30807-30809	IN	denotes	of
T5326	30810-30812	NN	denotes	B6
T5327	30813-30817	NNS	denotes	mice
T5328	30818-30826	VBN	denotes	measured
T5329	30827-30829	IN	denotes	in
T5330	30830-30833	DT	denotes	the
T5331	30834-30838	NN	denotes	hour
T5332	30839-30844	JJ	denotes	prior
T5333	30845-30847	IN	denotes	to
T5334	30848-30853	NN	denotes	onset
T5335	30854-30856	IN	denotes	of
T5336	30857-30860	DT	denotes	the
T5338	30861-30865	JJ	denotes	dark
T5337	30866-30872	NN	denotes	period
T5319	30873-30881	VBD	denotes	appeared
T5339	30882-30884	TO	denotes	to
T5340	30885-30887	VB	denotes	be
T5341	30888-30894	JJR	denotes	higher
T5342	30895-30899	IN	denotes	than
T5343	30900-30902	IN	denotes	at
T5344	30903-30908	JJ	denotes	other
T5345	30909-30914	NNS	denotes	times
T5346	30915-30917	IN	denotes	of
T5347	30918-30921	NN	denotes	day
T5348	30921-30922	.	denotes	.
T5349	30922-31131	sentence	denotes	Previously, a rise of IOP was reported to occur before onset of the dark period in rats [21], and rats and rabbits were shown to have higher IOP during the dark period compared to the light period [21,68,69].
T5350	30923-30933	RB	denotes	Previously
T5352	30933-30935	,	denotes	,
T5353	30935-30936	DT	denotes	a
T5354	30937-30941	NN	denotes	rise
T5355	30942-30944	IN	denotes	of
T5356	30945-30948	NN	denotes	IOP
T5357	30949-30952	VBD	denotes	was
T5351	30953-30961	VBN	denotes	reported
T5358	30962-30964	TO	denotes	to
T5359	30965-30970	VB	denotes	occur
T5360	30971-30977	IN	denotes	before
T5361	30978-30983	NN	denotes	onset
T5362	30984-30986	IN	denotes	of
T5363	30987-30990	DT	denotes	the
T5365	30991-30995	JJ	denotes	dark
T5364	30996-31002	NN	denotes	period
T5366	31003-31005	IN	denotes	in
T5367	31006-31010	NNS	denotes	rats
T5368	31011-31012	-LRB-	denotes	[
T5369	31012-31014	CD	denotes	21
T5370	31014-31015	-RRB-	denotes	]
T5371	31015-31017	,	denotes	,
T5372	31017-31020	CC	denotes	and
T5373	31021-31025	NNS	denotes	rats
T5375	31026-31029	CC	denotes	and
T5376	31030-31037	NNS	denotes	rabbits
T5377	31038-31042	VBD	denotes	were
T5374	31043-31048	VBN	denotes	shown
T5378	31049-31051	TO	denotes	to
T5379	31052-31056	VB	denotes	have
T5380	31057-31063	JJR	denotes	higher
T5381	31064-31067	NN	denotes	IOP
T5382	31068-31074	IN	denotes	during
T5383	31075-31078	DT	denotes	the
T5385	31079-31083	JJ	denotes	dark
T5384	31084-31090	NN	denotes	period
T5386	31091-31099	VBN	denotes	compared
T5387	31100-31102	IN	denotes	to
T5388	31103-31106	DT	denotes	the
T5390	31107-31112	JJ	denotes	light
T5389	31113-31119	NN	denotes	period
T5391	31120-31121	-LRB-	denotes	[
T5393	31121-31123	CD	denotes	21
T5394	31123-31124	,	denotes	,
T5395	31124-31126	CD	denotes	68
T5396	31126-31127	,	denotes	,
T5392	31127-31129	CD	denotes	69
T5397	31129-31130	-RRB-	denotes	]
T5398	31130-31131	.	denotes	.
T5399	31131-31299	sentence	denotes	Thus, we compared the IOPs of mice at different times of day and identified several strains with significantly higher IOP during the dark compared to the light period.
T5400	31132-31136	RB	denotes	Thus
T5402	31136-31138	,	denotes	,
T5403	31138-31140	PRP	denotes	we
T5401	31141-31149	VBD	denotes	compared
T5404	31150-31153	DT	denotes	the
T5405	31154-31158	NNS	denotes	IOPs
T5406	31159-31161	IN	denotes	of
T5407	31162-31166	NNS	denotes	mice
T5408	31167-31169	IN	denotes	at
T5409	31170-31179	JJ	denotes	different
T5410	31180-31185	NNS	denotes	times
T5411	31186-31188	IN	denotes	of
T5412	31189-31192	NN	denotes	day
T5413	31193-31196	CC	denotes	and
T5414	31197-31207	VBD	denotes	identified
T5415	31208-31215	JJ	denotes	several
T5416	31216-31223	NNS	denotes	strains
T5417	31224-31228	IN	denotes	with
T5418	31229-31242	RB	denotes	significantly
T5420	31243-31249	JJR	denotes	higher
T5419	31250-31253	NN	denotes	IOP
T5421	31254-31260	IN	denotes	during
T5422	31261-31264	DT	denotes	the
T5423	31265-31269	NN	denotes	dark
T5424	31270-31278	VBN	denotes	compared
T5425	31279-31281	IN	denotes	to
T5426	31282-31285	DT	denotes	the
T5427	31286-31291	JJ	denotes	light
T5428	31292-31298	NN	denotes	period
T5429	31298-31299	.	denotes	.
T5430	31299-31378	sentence	denotes	The magnitude of the difference varies with strain, and was greatest in SWR/J.
T5431	31300-31303	DT	denotes	The
T5432	31304-31313	NN	denotes	magnitude
T5434	31314-31316	IN	denotes	of
T5435	31317-31320	DT	denotes	the
T5436	31321-31331	NN	denotes	difference
T5433	31332-31338	VBZ	denotes	varies
T5437	31339-31343	IN	denotes	with
T5438	31344-31350	NN	denotes	strain
T5439	31350-31352	,	denotes	,
T5440	31352-31355	CC	denotes	and
T5441	31356-31359	VBD	denotes	was
T5442	31360-31368	JJS	denotes	greatest
T5443	31369-31371	IN	denotes	in
T5444	31372-31375	NN	denotes	SWR
T5446	31375-31376	HYPH	denotes	/
T5445	31376-31377	NN	denotes	J
T5447	31377-31378	.	denotes	.
T5448	31378-31556	sentence	denotes	The IOP increase in the dark is not dependent on functional rod and cone photoreceptors since these cells degenerate in SWR/J mice due to homozygosity for the Pde6brd1 mutation.
T5449	31379-31382	DT	denotes	The
T5451	31383-31386	NN	denotes	IOP
T5450	31387-31395	NN	denotes	increase
T5453	31396-31398	IN	denotes	in
T5454	31399-31402	DT	denotes	the
T5455	31403-31407	NN	denotes	dark
T5452	31408-31410	VBZ	denotes	is
T5456	31411-31414	RB	denotes	not
T5457	31415-31424	JJ	denotes	dependent
T5458	31425-31427	IN	denotes	on
T5459	31428-31438	JJ	denotes	functional
T5461	31439-31442	NN	denotes	rod
T5462	31443-31446	CC	denotes	and
T5463	31447-31451	NN	denotes	cone
T5460	31452-31466	NNS	denotes	photoreceptors
T5464	31467-31472	IN	denotes	since
T5466	31473-31478	DT	denotes	these
T5467	31479-31484	NNS	denotes	cells
T5465	31485-31495	VBP	denotes	degenerate
T5468	31496-31498	IN	denotes	in
T5469	31499-31502	NN	denotes	SWR
T5471	31502-31503	HYPH	denotes	/
T5470	31503-31504	NN	denotes	J
T5472	31505-31509	NNS	denotes	mice
T5473	31510-31513	IN	denotes	due
T5474	31514-31516	IN	denotes	to
T5475	31517-31529	NN	denotes	homozygosity
T5476	31530-31533	IN	denotes	for
T5477	31534-31537	DT	denotes	the
T5479	31538-31546	NN	denotes	Pde6brd1
T5478	31547-31555	NN	denotes	mutation
T5480	31555-31556	.	denotes	.
T5481	31556-31696	sentence	denotes	In agreement with this finding, circadian regulation of wheel running by light was previously reported in mice lacking rods and cones [70].
T5482	31557-31559	IN	denotes	In
T5484	31560-31569	NN	denotes	agreement
T5485	31570-31574	IN	denotes	with
T5486	31575-31579	DT	denotes	this
T5487	31580-31587	NN	denotes	finding
T5488	31587-31589	,	denotes	,
T5489	31589-31598	JJ	denotes	circadian
T5490	31599-31609	NN	denotes	regulation
T5491	31610-31612	IN	denotes	of
T5492	31613-31618	NN	denotes	wheel
T5493	31619-31626	NN	denotes	running
T5494	31627-31629	IN	denotes	by
T5495	31630-31635	NN	denotes	light
T5496	31636-31639	VBD	denotes	was
T5497	31640-31650	RB	denotes	previously
T5483	31651-31659	VBN	denotes	reported
T5498	31660-31662	IN	denotes	in
T5499	31663-31667	NNS	denotes	mice
T5500	31668-31675	VBG	denotes	lacking
T5501	31676-31680	NNS	denotes	rods
T5502	31681-31684	CC	denotes	and
T5503	31685-31690	NNS	denotes	cones
T5504	31691-31692	-LRB-	denotes	[
T5505	31692-31694	CD	denotes	70
T5506	31694-31695	-RRB-	denotes	]
T5507	31695-31696	.	denotes	.
T5508	31696-31821	sentence	denotes	Interestingly, the IOP of strain CBA/CaJ, which has one of the highest daytime IOPs does not appear to increase in the dark.
T5509	31697-31710	RB	denotes	Interestingly
T5511	31710-31712	,	denotes	,
T5512	31712-31715	DT	denotes	the
T5513	31716-31719	NN	denotes	IOP
T5514	31720-31722	IN	denotes	of
T5515	31723-31729	NN	denotes	strain
T5517	31730-31733	NN	denotes	CBA
T5518	31733-31734	HYPH	denotes	/
T5516	31734-31737	NN	denotes	CaJ
T5519	31737-31739	,	denotes	,
T5520	31739-31744	WDT	denotes	which
T5521	31745-31748	VBZ	denotes	has
T5522	31749-31752	CD	denotes	one
T5523	31753-31755	IN	denotes	of
T5524	31756-31759	DT	denotes	the
T5526	31760-31767	JJS	denotes	highest
T5527	31768-31775	NN	denotes	daytime
T5525	31776-31780	NNS	denotes	IOPs
T5528	31781-31785	VBZ	denotes	does
T5529	31786-31789	RB	denotes	not
T5510	31790-31796	VB	denotes	appear
T5530	31797-31799	TO	denotes	to
T5531	31800-31808	VB	denotes	increase
T5532	31809-31811	IN	denotes	in
T5533	31812-31815	DT	denotes	the
T5534	31816-31820	NN	denotes	dark
T5535	31820-31821	.	denotes	.
T5536	31821-32031	sentence	denotes	Further more detailed studies are needed to define the characteristics of the diurnal rhythm of intraocular pressure in mice, and to determine whether it is lacking or has a different timing in strain CBA/CaJ.
T5537	31822-31829	RB	denotes	Further
T5539	31830-31834	RBR	denotes	more
T5541	31835-31843	JJ	denotes	detailed
T5540	31844-31851	NNS	denotes	studies
T5542	31852-31855	VBP	denotes	are
T5538	31856-31862	VBN	denotes	needed
T5543	31863-31865	TO	denotes	to
T5544	31866-31872	VB	denotes	define
T5545	31873-31876	DT	denotes	the
T5546	31877-31892	NNS	denotes	characteristics
T5547	31893-31895	IN	denotes	of
T5548	31896-31899	DT	denotes	the
T5550	31900-31907	JJ	denotes	diurnal
T5549	31908-31914	NN	denotes	rhythm
T5551	31915-31917	IN	denotes	of
T5552	31918-31929	JJ	denotes	intraocular
T5553	31930-31938	NN	denotes	pressure
T5554	31939-31941	IN	denotes	in
T5555	31942-31946	NNS	denotes	mice
T5556	31946-31948	,	denotes	,
T5557	31948-31951	CC	denotes	and
T5558	31952-31954	TO	denotes	to
T5559	31955-31964	VB	denotes	determine
T5560	31965-31972	IN	denotes	whether
T5562	31973-31975	PRP	denotes	it
T5561	31976-31978	VBZ	denotes	is
T5563	31979-31986	JJ	denotes	lacking
T5564	31987-31989	CC	denotes	or
T5565	31990-31993	VBZ	denotes	has
T5566	31994-31995	DT	denotes	a
T5568	31996-32005	JJ	denotes	different
T5567	32006-32012	NN	denotes	timing
T5569	32013-32015	IN	denotes	in
T5570	32016-32022	NN	denotes	strain
T5572	32023-32026	NN	denotes	CBA
T5573	32026-32027	HYPH	denotes	/
T5571	32027-32030	NN	denotes	CaJ
T5574	32030-32031	.	denotes	.
T5575	32031-32191	sentence	denotes	Analysis of these mouse strains may increase understanding of the molecular mechanisms controlling diurnal rhythms of IOP and that may be relevant to glaucoma.
T5576	32032-32040	NN	denotes	Analysis
T5578	32041-32043	IN	denotes	of
T5579	32044-32049	DT	denotes	these
T5581	32050-32055	NN	denotes	mouse
T5580	32056-32063	NNS	denotes	strains
T5582	32064-32067	MD	denotes	may
T5577	32068-32076	VB	denotes	increase
T5583	32077-32090	NN	denotes	understanding
T5584	32091-32093	IN	denotes	of
T5585	32094-32097	DT	denotes	the
T5587	32098-32107	JJ	denotes	molecular
T5586	32108-32118	NNS	denotes	mechanisms
T5588	32119-32130	VBG	denotes	controlling
T5589	32131-32138	JJ	denotes	diurnal
T5590	32139-32146	NNS	denotes	rhythms
T5591	32147-32149	IN	denotes	of
T5592	32150-32153	NN	denotes	IOP
T5593	32154-32157	CC	denotes	and
T5594	32158-32162	DT	denotes	that
T5596	32163-32166	MD	denotes	may
T5595	32167-32169	VB	denotes	be
T5597	32170-32178	JJ	denotes	relevant
T5598	32179-32181	IN	denotes	to
T5599	32182-32190	NN	denotes	glaucoma
T5600	32190-32191	.	denotes	.
T5691	32193-32197	NN	denotes	Car2
T5692	32198-32208	NN	denotes	deficiency
T5694	32209-32213	VBZ	denotes	does
T5695	32214-32217	RB	denotes	not
T5693	32218-32223	VB	denotes	alter
T5696	32224-32227	NN	denotes	IOP
T5697	32227-32373	sentence	denotes	Bicarbonate formation is important for aqueous humor secretion from the ciliary processes and carbonic anhydrase (CA) facilitates this secretion.
T5698	32228-32239	NN	denotes	Bicarbonate
T5699	32240-32249	NN	denotes	formation
T5700	32250-32252	VBZ	denotes	is
T5701	32253-32262	JJ	denotes	important
T5702	32263-32266	IN	denotes	for
T5703	32267-32274	JJ	denotes	aqueous
T5705	32275-32280	NN	denotes	humor
T5704	32281-32290	NN	denotes	secretion
T5706	32291-32295	IN	denotes	from
T5707	32296-32299	DT	denotes	the
T5709	32300-32307	JJ	denotes	ciliary
T5708	32308-32317	NNS	denotes	processes
T5710	32318-32321	CC	denotes	and
T5711	32322-32330	JJ	denotes	carbonic
T5712	32331-32340	NN	denotes	anhydrase
T5714	32341-32342	-LRB-	denotes	(
T5715	32342-32344	NN	denotes	CA
T5716	32344-32345	-RRB-	denotes	)
T5713	32346-32357	VBZ	denotes	facilitates
T5717	32358-32362	DT	denotes	this
T5718	32363-32372	NN	denotes	secretion
T5719	32372-32373	.	denotes	.
T5720	32373-32498	sentence	denotes	There are multiple forms of CA and the CAII isoform is reported to be the predominant form in the ciliary processes [71,72].
T5721	32374-32379	EX	denotes	There
T5722	32380-32383	VBP	denotes	are
T5723	32384-32392	JJ	denotes	multiple
T5724	32393-32398	NNS	denotes	forms
T5725	32399-32401	IN	denotes	of
T5726	32402-32404	NN	denotes	CA
T5727	32405-32408	CC	denotes	and
T5728	32409-32412	DT	denotes	the
T5730	32413-32417	NN	denotes	CAII
T5729	32418-32425	NN	denotes	isoform
T5732	32426-32428	VBZ	denotes	is
T5731	32429-32437	VBN	denotes	reported
T5733	32438-32440	TO	denotes	to
T5734	32441-32443	VB	denotes	be
T5735	32444-32447	DT	denotes	the
T5737	32448-32459	JJ	denotes	predominant
T5736	32460-32464	NN	denotes	form
T5738	32465-32467	IN	denotes	in
T5739	32468-32471	DT	denotes	the
T5741	32472-32479	JJ	denotes	ciliary
T5740	32480-32489	NNS	denotes	processes
T5742	32490-32491	-LRB-	denotes	[
T5744	32491-32493	CD	denotes	71
T5745	32493-32494	,	denotes	,
T5743	32494-32496	CD	denotes	72
T5746	32496-32497	-RRB-	denotes	]
T5747	32497-32498	.	denotes	.
T5748	32498-32624	sentence	denotes	Our experiments show that a genetic deficiency of CAII in mice homozygous for a mutation in the Car2 gene does not alter IOP.
T5749	32499-32502	PRP$	denotes	Our
T5750	32503-32514	NNS	denotes	experiments
T5751	32515-32519	VBP	denotes	show
T5752	32520-32524	IN	denotes	that
T5754	32525-32526	DT	denotes	a
T5756	32527-32534	JJ	denotes	genetic
T5755	32535-32545	NN	denotes	deficiency
T5757	32546-32548	IN	denotes	of
T5758	32549-32553	NN	denotes	CAII
T5759	32554-32556	IN	denotes	in
T5760	32557-32561	NNS	denotes	mice
T5761	32562-32572	JJ	denotes	homozygous
T5762	32573-32576	IN	denotes	for
T5763	32577-32578	DT	denotes	a
T5764	32579-32587	NN	denotes	mutation
T5765	32588-32590	IN	denotes	in
T5766	32591-32594	DT	denotes	the
T5768	32595-32599	NN	denotes	Car2
T5767	32600-32604	NN	denotes	gene
T5769	32605-32609	VBZ	denotes	does
T5770	32610-32613	RB	denotes	not
T5753	32614-32619	VB	denotes	alter
T5771	32620-32623	NN	denotes	IOP
T5772	32623-32624	.	denotes	.
T5773	32624-32800	sentence	denotes	CAIV activity was recently demonstrated in the ciliary processes [73] and so our data may support a more substantial role for CAIV compared to CAII in aqueous humor secretion.
T5774	32625-32629	NN	denotes	CAIV
T5775	32630-32638	NN	denotes	activity
T5777	32639-32642	VBD	denotes	was
T5778	32643-32651	RB	denotes	recently
T5776	32652-32664	VBN	denotes	demonstrated
T5779	32665-32667	IN	denotes	in
T5780	32668-32671	DT	denotes	the
T5782	32672-32679	JJ	denotes	ciliary
T5781	32680-32689	NNS	denotes	processes
T5783	32690-32691	-LRB-	denotes	[
T5784	32691-32693	CD	denotes	73
T5785	32693-32694	-RRB-	denotes	]
T5786	32695-32698	CC	denotes	and
T5787	32699-32701	RB	denotes	so
T5788	32702-32705	PRP$	denotes	our
T5789	32706-32710	NNS	denotes	data
T5791	32711-32714	MD	denotes	may
T5790	32715-32722	VB	denotes	support
T5792	32723-32724	DT	denotes	a
T5794	32725-32729	RBR	denotes	more
T5795	32730-32741	JJ	denotes	substantial
T5793	32742-32746	NN	denotes	role
T5796	32747-32750	IN	denotes	for
T5797	32751-32755	NN	denotes	CAIV
T5798	32756-32764	VBN	denotes	compared
T5799	32765-32767	IN	denotes	to
T5800	32768-32772	NN	denotes	CAII
T5801	32773-32775	IN	denotes	in
T5802	32776-32783	JJ	denotes	aqueous
T5804	32784-32789	NN	denotes	humor
T5803	32790-32799	NN	denotes	secretion
T5805	32799-32800	.	denotes	.
T5806	32800-32996	sentence	denotes	It also is possible that CAII substantially contributes to aqueous humor secretion but that functional mouse CAIV is sufficient to prevent an effect of CAII deficiency on IOP in Car2 mutant mice.
T5807	32801-32803	PRP	denotes	It
T5809	32804-32808	RB	denotes	also
T5808	32809-32811	VBZ	denotes	is
T5810	32812-32820	JJ	denotes	possible
T5811	32821-32825	IN	denotes	that
T5813	32826-32830	NN	denotes	CAII
T5814	32831-32844	RB	denotes	substantially
T5812	32845-32856	VBZ	denotes	contributes
T5815	32857-32859	IN	denotes	to
T5816	32860-32867	JJ	denotes	aqueous
T5817	32868-32873	NN	denotes	humor
T5818	32874-32883	NN	denotes	secretion
T5819	32884-32887	CC	denotes	but
T5820	32888-32892	IN	denotes	that
T5822	32893-32903	JJ	denotes	functional
T5824	32904-32909	NN	denotes	mouse
T5823	32910-32914	NN	denotes	CAIV
T5821	32915-32917	VBZ	denotes	is
T5825	32918-32928	JJ	denotes	sufficient
T5826	32929-32931	TO	denotes	to
T5827	32932-32939	VB	denotes	prevent
T5828	32940-32942	DT	denotes	an
T5829	32943-32949	NN	denotes	effect
T5830	32950-32952	IN	denotes	of
T5831	32953-32957	NN	denotes	CAII
T5832	32958-32968	NN	denotes	deficiency
T5833	32969-32971	IN	denotes	on
T5834	32972-32975	NN	denotes	IOP
T5835	32976-32978	IN	denotes	in
T5836	32979-32983	NN	denotes	Car2
T5838	32984-32990	JJ	denotes	mutant
T5837	32991-32995	NNS	denotes	mice
T5839	32995-32996	.	denotes	.
T5840	32996-33139	sentence	denotes	In support of a role for both enzymes, a greater than 90% inhibition of CA is required for significant reduction of aqueous secretion [71,72].
T5841	32997-32999	IN	denotes	In
T5843	33000-33007	NN	denotes	support
T5844	33008-33010	IN	denotes	of
T5845	33011-33012	DT	denotes	a
T5846	33013-33017	NN	denotes	role
T5847	33018-33021	IN	denotes	for
T5848	33022-33026	DT	denotes	both
T5849	33027-33034	NNS	denotes	enzymes
T5850	33034-33036	,	denotes	,
T5851	33036-33037	DT	denotes	a
T5853	33038-33045	JJR	denotes	greater
T5855	33046-33050	IN	denotes	than
T5854	33051-33053	CD	denotes	90
T5856	33053-33054	NN	denotes	%
T5852	33055-33065	NN	denotes	inhibition
T5857	33066-33068	IN	denotes	of
T5858	33069-33071	NN	denotes	CA
T5859	33072-33074	VBZ	denotes	is
T5842	33075-33083	VBN	denotes	required
T5860	33084-33087	IN	denotes	for
T5861	33088-33099	JJ	denotes	significant
T5862	33100-33109	NN	denotes	reduction
T5863	33110-33112	IN	denotes	of
T5864	33113-33120	JJ	denotes	aqueous
T5865	33121-33130	NN	denotes	secretion
T5866	33131-33132	-LRB-	denotes	[
T5868	33132-33134	CD	denotes	71
T5869	33134-33135	,	denotes	,
T5867	33135-33137	CD	denotes	72
T5870	33137-33138	-RRB-	denotes	]
T5871	33138-33139	.	denotes	.
T5957	33141-33151	NN	denotes	Tyrosinase
T5958	33152-33162	NN	denotes	deficiency
T5959	33163-33170	VBZ	denotes	results
T5960	33171-33173	IN	denotes	in
T5961	33174-33183	VBN	denotes	increased
T5962	33184-33187	NN	denotes	IOP
T5963	33187-33253	sentence	denotes	Tyrosinase is the first enzyme of the pigment production pathway.
T5964	33188-33198	NN	denotes	Tyrosinase
T5965	33199-33201	VBZ	denotes	is
T5966	33202-33205	DT	denotes	the
T5968	33206-33211	JJ	denotes	first
T5967	33212-33218	NN	denotes	enzyme
T5969	33219-33221	IN	denotes	of
T5970	33222-33225	DT	denotes	the
T5972	33226-33233	NN	denotes	pigment
T5973	33234-33244	NN	denotes	production
T5971	33245-33252	NN	denotes	pathway
T5974	33252-33253	.	denotes	.
T5975	33253-33328	sentence	denotes	Tyrosinase deficiency causes albinism and has various ocular consequences.
T5976	33254-33264	NN	denotes	Tyrosinase
T5977	33265-33275	NN	denotes	deficiency
T5978	33276-33282	VBZ	denotes	causes
T5979	33283-33291	NN	denotes	albinism
T5980	33292-33295	CC	denotes	and
T5981	33296-33299	VBZ	denotes	has
T5982	33300-33307	JJ	denotes	various
T5984	33308-33314	JJ	denotes	ocular
T5983	33315-33327	NNS	denotes	consequences
T5985	33327-33328	.	denotes	.
T5986	33328-33475	sentence	denotes	These include alteration of the number of ipsilaterally projecting retinal axons and substantially increased light penetration past the iris [74].
T5987	33329-33334	DT	denotes	These
T5988	33335-33342	VBP	denotes	include
T5989	33343-33353	NN	denotes	alteration
T5990	33354-33356	IN	denotes	of
T5991	33357-33360	DT	denotes	the
T5992	33361-33367	NN	denotes	number
T5993	33368-33370	IN	denotes	of
T5994	33371-33384	RB	denotes	ipsilaterally
T5995	33385-33395	VBG	denotes	projecting
T5997	33396-33403	JJ	denotes	retinal
T5996	33404-33409	NNS	denotes	axons
T5998	33410-33413	CC	denotes	and
T5999	33414-33427	RB	denotes	substantially
T6000	33428-33437	VBN	denotes	increased
T6002	33438-33443	JJ	denotes	light
T6001	33444-33455	NN	denotes	penetration
T6003	33456-33460	IN	denotes	past
T6004	33461-33464	DT	denotes	the
T6005	33465-33469	NN	denotes	iris
T6006	33470-33471	-LRB-	denotes	[
T6007	33471-33473	CD	denotes	74
T6008	33473-33474	-RRB-	denotes	]
T6009	33474-33475	.	denotes	.
T6010	33475-33536	sentence	denotes	It is not known if these abnormalities affect mammalian IOP.
T6011	33476-33478	PRP	denotes	It
T6013	33479-33481	VBZ	denotes	is
T6014	33482-33485	RB	denotes	not
T6012	33486-33491	VBN	denotes	known
T6015	33492-33494	IN	denotes	if
T6017	33495-33500	DT	denotes	these
T6018	33501-33514	NNS	denotes	abnormalities
T6016	33515-33521	VBP	denotes	affect
T6019	33522-33531	JJ	denotes	mammalian
T6020	33532-33535	NN	denotes	IOP
T6021	33535-33536	.	denotes	.
T6022	33536-33663	sentence	denotes	Here, we show increased IOP in mice lacking tyrosinase activity compared to otherwise genetically identical pigmented B6 mice.
T6023	33537-33541	RB	denotes	Here
T6025	33541-33543	,	denotes	,
T6026	33543-33545	PRP	denotes	we
T6024	33546-33550	VBP	denotes	show
T6027	33551-33560	VBN	denotes	increased
T6028	33561-33564	NN	denotes	IOP
T6029	33565-33567	IN	denotes	in
T6030	33568-33572	NNS	denotes	mice
T6031	33573-33580	VBG	denotes	lacking
T6032	33581-33591	NN	denotes	tyrosinase
T6033	33592-33600	NN	denotes	activity
T6034	33601-33609	VBN	denotes	compared
T6035	33610-33612	IN	denotes	to
T6036	33613-33622	RB	denotes	otherwise
T6038	33623-33634	RB	denotes	genetically
T6037	33635-33644	JJ	denotes	identical
T6040	33645-33654	VBN	denotes	pigmented
T6041	33655-33657	NN	denotes	B6
T6039	33658-33662	NNS	denotes	mice
T6042	33662-33663	.	denotes	.
T6043	33663-33797	sentence	denotes	Additionally, IOP differences between the light and dark period of the day were detected in the pigmented but not the albino B6 mice.
T6044	33664-33676	RB	denotes	Additionally
T6046	33676-33678	,	denotes	,
T6047	33678-33681	NN	denotes	IOP
T6048	33682-33693	NNS	denotes	differences
T6049	33694-33701	IN	denotes	between
T6050	33702-33705	DT	denotes	the
T6052	33706-33711	NN	denotes	light
T6054	33712-33715	CC	denotes	and
T6053	33716-33720	JJ	denotes	dark
T6051	33721-33727	NN	denotes	period
T6055	33728-33730	IN	denotes	of
T6056	33731-33734	DT	denotes	the
T6057	33735-33738	NN	denotes	day
T6058	33739-33743	VBD	denotes	were
T6045	33744-33752	VBN	denotes	detected
T6059	33753-33755	IN	denotes	in
T6060	33756-33759	DT	denotes	the
T6061	33760-33769	VBN	denotes	pigmented
T6062	33770-33773	CC	denotes	but
T6063	33774-33777	RB	denotes	not
T6064	33778-33781	DT	denotes	the
T6065	33782-33788	NN	denotes	albino
T6067	33789-33791	NN	denotes	B6
T6066	33792-33796	NNS	denotes	mice
T6068	33796-33797	.	denotes	.
T6069	33797-33859	sentence	denotes	Thus, albinism can affect the diurnal pattern of IOP changes.
T6070	33798-33802	RB	denotes	Thus
T6072	33802-33804	,	denotes	,
T6073	33804-33812	NN	denotes	albinism
T6074	33813-33816	MD	denotes	can
T6071	33817-33823	VB	denotes	affect
T6075	33824-33827	DT	denotes	the
T6077	33828-33835	JJ	denotes	diurnal
T6076	33836-33843	NN	denotes	pattern
T6078	33844-33846	IN	denotes	of
T6079	33847-33850	NN	denotes	IOP
T6080	33851-33858	NNS	denotes	changes
T6081	33858-33859	.	denotes	.
T6082	33859-34040	sentence	denotes	In agreement with this result, mice with albino eyes that are homozygous for tyrosinase or pink eye dilution mutations have altered diurnal rhythms compared to pigmented mice [75].
T6083	33860-33862	IN	denotes	In
T6085	33863-33872	NN	denotes	agreement
T6086	33873-33877	IN	denotes	with
T6087	33878-33882	DT	denotes	this
T6088	33883-33889	NN	denotes	result
T6089	33889-33891	,	denotes	,
T6090	33891-33895	NNS	denotes	mice
T6091	33896-33900	IN	denotes	with
T6092	33901-33907	NN	denotes	albino
T6093	33908-33912	NNS	denotes	eyes
T6094	33913-33917	WDT	denotes	that
T6095	33918-33921	VBP	denotes	are
T6096	33922-33932	JJ	denotes	homozygous
T6097	33933-33936	IN	denotes	for
T6098	33937-33947	NN	denotes	tyrosinase
T6099	33948-33950	CC	denotes	or
T6100	33951-33955	JJ	denotes	pink
T6101	33956-33959	NN	denotes	eye
T6103	33960-33968	NN	denotes	dilution
T6102	33969-33978	NNS	denotes	mutations
T6084	33979-33983	VBP	denotes	have
T6104	33984-33991	VBN	denotes	altered
T6106	33992-33999	JJ	denotes	diurnal
T6105	34000-34007	NNS	denotes	rhythms
T6107	34008-34016	VBN	denotes	compared
T6108	34017-34019	IN	denotes	to
T6109	34020-34029	JJ	denotes	pigmented
T6110	34030-34034	NNS	denotes	mice
T6111	34035-34036	-LRB-	denotes	[
T6112	34036-34038	CD	denotes	75
T6113	34038-34039	-RRB-	denotes	]
T6114	34039-34040	.	denotes	.
T6115	34040-34274	sentence	denotes	Albinism by itself is either not sufficient to alter the diurnal rhythm of IOP or alters it in different ways depending upon genetic background, however, since the albino strains BALB/cByJ and SWR/J had increased IOP during the dark.
T6116	34041-34049	NN	denotes	Albinism
T6118	34050-34052	IN	denotes	by
T6119	34053-34059	PRP	denotes	itself
T6117	34060-34062	VBZ	denotes	is
T6120	34063-34069	CC	denotes	either
T6122	34070-34073	RB	denotes	not
T6121	34074-34084	JJ	denotes	sufficient
T6123	34085-34087	TO	denotes	to
T6124	34088-34093	VB	denotes	alter
T6125	34094-34097	DT	denotes	the
T6127	34098-34105	JJ	denotes	diurnal
T6126	34106-34112	NN	denotes	rhythm
T6128	34113-34115	IN	denotes	of
T6129	34116-34119	NN	denotes	IOP
T6130	34120-34122	CC	denotes	or
T6131	34123-34129	VBZ	denotes	alters
T6132	34130-34132	PRP	denotes	it
T6133	34133-34135	IN	denotes	in
T6134	34136-34145	JJ	denotes	different
T6135	34146-34150	NNS	denotes	ways
T6136	34151-34160	VBG	denotes	depending
T6137	34161-34165	IN	denotes	upon
T6138	34166-34173	JJ	denotes	genetic
T6139	34174-34184	NN	denotes	background
T6140	34184-34186	,	denotes	,
T6141	34186-34193	RB	denotes	however
T6142	34193-34195	,	denotes	,
T6143	34195-34200	IN	denotes	since
T6145	34201-34204	DT	denotes	the
T6147	34205-34211	NN	denotes	albino
T6146	34212-34219	NNS	denotes	strains
T6148	34220-34224	NN	denotes	BALB
T6150	34224-34225	HYPH	denotes	/
T6149	34225-34229	NN	denotes	cByJ
T6151	34230-34233	CC	denotes	and
T6152	34234-34237	NN	denotes	SWR
T6154	34237-34238	HYPH	denotes	/
T6153	34238-34239	NN	denotes	J
T6144	34240-34243	VBD	denotes	had
T6155	34244-34253	VBN	denotes	increased
T6156	34254-34257	NN	denotes	IOP
T6157	34258-34264	IN	denotes	during
T6158	34265-34268	DT	denotes	the
T6159	34269-34273	NN	denotes	dark
T6160	34273-34274	.	denotes	.
T6161	34274-34364	sentence	denotes	Diurnal rhythms are known to depend on visual pathways and to respond to light intensity.
T6162	34275-34282	JJ	denotes	Diurnal
T6163	34283-34290	NNS	denotes	rhythms
T6165	34291-34294	VBP	denotes	are
T6164	34295-34300	VBN	denotes	known
T6166	34301-34303	TO	denotes	to
T6167	34304-34310	VB	denotes	depend
T6168	34311-34313	IN	denotes	on
T6169	34314-34320	JJ	denotes	visual
T6170	34321-34329	NNS	denotes	pathways
T6171	34330-34333	CC	denotes	and
T6172	34334-34336	TO	denotes	to
T6173	34337-34344	VB	denotes	respond
T6174	34345-34347	IN	denotes	to
T6175	34348-34353	JJ	denotes	light
T6176	34354-34363	NN	denotes	intensity
T6177	34363-34364	.	denotes	.
T6178	34364-34489	sentence	denotes	Exposing rats to 24 hours of low light abrogates the diurnal fluctuation of IOP and results in constantly elevated IOP [36].
T6179	34365-34373	VBG	denotes	Exposing
T6181	34374-34378	NNS	denotes	rats
T6182	34379-34381	IN	denotes	to
T6183	34382-34384	CD	denotes	24
T6184	34385-34390	NNS	denotes	hours
T6185	34391-34393	IN	denotes	of
T6186	34394-34397	JJ	denotes	low
T6187	34398-34403	NN	denotes	light
T6180	34404-34413	VBZ	denotes	abrogates
T6188	34414-34417	DT	denotes	the
T6190	34418-34425	JJ	denotes	diurnal
T6189	34426-34437	NN	denotes	fluctuation
T6191	34438-34440	IN	denotes	of
T6192	34441-34444	NN	denotes	IOP
T6193	34445-34448	CC	denotes	and
T6194	34449-34456	VBZ	denotes	results
T6195	34457-34459	IN	denotes	in
T6196	34460-34470	RB	denotes	constantly
T6198	34471-34479	JJ	denotes	elevated
T6197	34480-34483	NN	denotes	IOP
T6199	34484-34485	-LRB-	denotes	[
T6200	34485-34487	CD	denotes	36
T6201	34487-34488	-RRB-	denotes	]
T6202	34488-34489	.	denotes	.
T6203	34489-34653	sentence	denotes	Further experiments will determine the nature of the diurnal rhythm of IOP in the albino B6 mice and if its alteration or other mechanisms result in IOP elevation.
T6204	34490-34497	JJR	denotes	Further
T6205	34498-34509	NNS	denotes	experiments
T6207	34510-34514	MD	denotes	will
T6206	34515-34524	VB	denotes	determine
T6208	34525-34528	DT	denotes	the
T6209	34529-34535	NN	denotes	nature
T6210	34536-34538	IN	denotes	of
T6211	34539-34542	DT	denotes	the
T6213	34543-34550	JJ	denotes	diurnal
T6212	34551-34557	NN	denotes	rhythm
T6214	34558-34560	IN	denotes	of
T6215	34561-34564	NN	denotes	IOP
T6216	34565-34567	IN	denotes	in
T6217	34568-34571	DT	denotes	the
T6219	34572-34578	NN	denotes	albino
T6220	34579-34581	NN	denotes	B6
T6218	34582-34586	NNS	denotes	mice
T6221	34587-34590	CC	denotes	and
T6222	34591-34593	IN	denotes	if
T6224	34594-34597	PRP$	denotes	its
T6225	34598-34608	NN	denotes	alteration
T6226	34609-34611	CC	denotes	or
T6227	34612-34617	JJ	denotes	other
T6228	34618-34628	NNS	denotes	mechanisms
T6223	34629-34635	VBP	denotes	result
T6229	34636-34638	IN	denotes	in
T6230	34639-34642	NN	denotes	IOP
T6231	34643-34652	NN	denotes	elevation
T6232	34652-34653	.	denotes	.
T6313	34667-34668	DT	denotes	A
T6315	34669-34674	JJ	denotes	broad
T6314	34675-34680	NN	denotes	range
T6299	34681-34683	IN	denotes	of
T6300	34684-34696	JJ	denotes	reproducible
T6302	34697-34700	NN	denotes	IOP
T6301	34701-34712	NNS	denotes	differences
T6316	34713-34719	VBZ	denotes	exists
T6303	34720-34727	IN	denotes	between
T6304	34728-34734	JJ	denotes	inbred
T6306	34735-34740	NN	denotes	mouse
T6305	34741-34748	NNS	denotes	strains
T6307	34749-34752	CC	denotes	and
T6308	34753-34754	DT	denotes	a
T6310	34755-34762	JJ	denotes	diurnal
T6309	34763-34769	NN	denotes	rhythm
T6312	34770-34772	IN	denotes	of
T6317	34773-34776	NN	denotes	IOP
T6311	34777-34783	VBZ	denotes	exists
T6318	34784-34786	IN	denotes	in
T6319	34787-34796	JJ	denotes	different
T6320	34797-34804	NNS	denotes	strains
T6321	34804-34805	.	denotes	.
T6322	34805-34890	sentence	denotes	Various factors have been variably associated with risk for increased IOP in humans.
T6323	34806-34813	JJ	denotes	Various
T6324	34814-34821	NNS	denotes	factors
T6326	34822-34826	VBP	denotes	have
T6327	34827-34831	VBN	denotes	been
T6328	34832-34840	RB	denotes	variably
T6325	34841-34851	VBN	denotes	associated
T6329	34852-34856	IN	denotes	with
T6330	34857-34861	NN	denotes	risk
T6331	34862-34865	IN	denotes	for
T6332	34866-34875	VBN	denotes	increased
T6333	34876-34879	NN	denotes	IOP
T6334	34880-34882	IN	denotes	in
T6335	34883-34889	NNS	denotes	humans
T6336	34889-34890	.	denotes	.
T6337	34890-34979	sentence	denotes	Genetically uniform, mice can be used to study the effects of these risk factors on IOP.
T6338	34891-34902	RB	denotes	Genetically
T6339	34903-34910	JJ	denotes	uniform
T6341	34910-34912	,	denotes	,
T6342	34912-34916	NNS	denotes	mice
T6343	34917-34920	MD	denotes	can
T6344	34921-34923	VB	denotes	be
T6340	34924-34928	VBN	denotes	used
T6345	34929-34931	TO	denotes	to
T6346	34932-34937	VB	denotes	study
T6347	34938-34941	DT	denotes	the
T6348	34942-34949	NNS	denotes	effects
T6349	34950-34952	IN	denotes	of
T6350	34953-34958	DT	denotes	these
T6352	34959-34963	NN	denotes	risk
T6351	34964-34971	NNS	denotes	factors
T6353	34972-34974	IN	denotes	on
T6354	34975-34978	NN	denotes	IOP
T6355	34978-34979	.	denotes	.
T6356	34979-35127	sentence	denotes	In trained hands, our measurement procedure is reliable, accurate and rapid enough to allow large scale genetic studies of factors determining IOP.
T6357	34980-34982	IN	denotes	In
T6359	34983-34990	JJ	denotes	trained
T6360	34991-34996	NNS	denotes	hands
T6361	34996-34998	,	denotes	,
T6362	34998-35001	PRP$	denotes	our
T6364	35002-35013	NN	denotes	measurement
T6363	35014-35023	NN	denotes	procedure
T6358	35024-35026	VBZ	denotes	is
T6365	35027-35035	JJ	denotes	reliable
T6367	35035-35037	,	denotes	,
T6368	35037-35045	JJ	denotes	accurate
T6369	35046-35049	CC	denotes	and
T6370	35050-35055	JJ	denotes	rapid
T6366	35056-35062	JJ	denotes	enough
T6371	35063-35065	TO	denotes	to
T6372	35066-35071	VB	denotes	allow
T6373	35072-35077	JJ	denotes	large
T6374	35078-35083	NN	denotes	scale
T6376	35084-35091	JJ	denotes	genetic
T6375	35092-35099	NNS	denotes	studies
T6377	35100-35102	IN	denotes	of
T6378	35103-35110	NNS	denotes	factors
T6379	35111-35122	VBG	denotes	determining
T6380	35123-35126	NN	denotes	IOP
T6381	35126-35127	.	denotes	.
T6382	35127-35221	sentence	denotes	Mice have great potential for helping to characterize the molecular mechanisms affecting IOP.
T6383	35128-35132	NNS	denotes	Mice
T6384	35133-35137	VBP	denotes	have
T6385	35138-35143	JJ	denotes	great
T6386	35144-35153	NN	denotes	potential
T6387	35154-35157	IN	denotes	for
T6388	35158-35165	VBG	denotes	helping
T6389	35166-35168	TO	denotes	to
T6390	35169-35181	VB	denotes	characterize
T6391	35182-35185	DT	denotes	the
T6393	35186-35195	JJ	denotes	molecular
T6392	35196-35206	NNS	denotes	mechanisms
T6394	35207-35216	VBG	denotes	affecting
T6395	35217-35220	NN	denotes	IOP
T6396	35220-35221	.	denotes	.
T6430	35246-35252	NN	denotes	Animal
T6431	35253-35262	NN	denotes	husbandry
T6432	35262-35385	sentence	denotes	All experiments were performed in compliance with the ARVO statement for use of animals in ophthalmic and vision research.
T6433	35263-35266	DT	denotes	All
T6434	35267-35278	NNS	denotes	experiments
T6436	35279-35283	VBD	denotes	were
T6435	35284-35293	VBN	denotes	performed
T6437	35294-35296	IN	denotes	in
T6438	35297-35307	NN	denotes	compliance
T6439	35308-35312	IN	denotes	with
T6440	35313-35316	DT	denotes	the
T6442	35317-35321	NN	denotes	ARVO
T6441	35322-35331	NN	denotes	statement
T6443	35332-35335	IN	denotes	for
T6444	35336-35339	NN	denotes	use
T6445	35340-35342	IN	denotes	of
T6446	35343-35350	NNS	denotes	animals
T6447	35351-35353	IN	denotes	in
T6448	35354-35364	JJ	denotes	ophthalmic
T6450	35365-35368	CC	denotes	and
T6451	35369-35375	NN	denotes	vision
T6449	35376-35384	NN	denotes	research
T6452	35384-35385	.	denotes	.
T6453	35385-35446	sentence	denotes	All mice were bred and maintained at The Jackson Laboratory.
T6454	35386-35389	DT	denotes	All
T6455	35390-35394	NNS	denotes	mice
T6457	35395-35399	VBD	denotes	were
T6456	35400-35404	VBN	denotes	bred
T6458	35405-35408	CC	denotes	and
T6459	35409-35419	VBN	denotes	maintained
T6460	35420-35422	IN	denotes	at
T6461	35423-35426	DT	denotes	The
T6463	35427-35434	NNP	denotes	Jackson
T6462	35435-35445	NNP	denotes	Laboratory
T6464	35445-35446	.	denotes	.
T6465	35446-35538	sentence	denotes	Mice were housed in cages containing white pine bedding and covered with polyester filters.
T6466	35447-35451	NNS	denotes	Mice
T6468	35452-35456	VBD	denotes	were
T6467	35457-35463	VBN	denotes	housed
T6469	35464-35466	IN	denotes	in
T6470	35467-35472	NNS	denotes	cages
T6471	35473-35483	VBG	denotes	containing
T6472	35484-35489	JJ	denotes	white
T6474	35490-35494	NN	denotes	pine
T6473	35495-35502	NN	denotes	bedding
T6475	35503-35506	CC	denotes	and
T6476	35507-35514	VBN	denotes	covered
T6477	35515-35519	IN	denotes	with
T6478	35520-35529	NN	denotes	polyester
T6479	35530-35537	NNS	denotes	filters
T6480	35537-35538	.	denotes	.
T6481	35538-35659	sentence	denotes	For most experiments, the mice were fed NIH31 (6 % fat) chow ad libitum, and their water was acidified to pH 2.8 to 3.2.
T6482	35539-35542	IN	denotes	For
T6484	35543-35547	JJS	denotes	most
T6485	35548-35559	NNS	denotes	experiments
T6486	35559-35561	,	denotes	,
T6487	35561-35564	DT	denotes	the
T6488	35565-35569	NNS	denotes	mice
T6489	35570-35574	VBD	denotes	were
T6483	35575-35578	VBN	denotes	fed
T6490	35579-35584	NN	denotes	NIH31
T6492	35585-35586	-LRB-	denotes	(
T6493	35586-35587	CD	denotes	6
T6494	35588-35589	NN	denotes	%
T6495	35590-35593	NN	denotes	fat
T6496	35593-35594	-RRB-	denotes	)
T6491	35595-35599	NN	denotes	chow
T6497	35600-35602	FW	denotes	ad
T6498	35603-35610	FW	denotes	libitum
T6499	35610-35612	,	denotes	,
T6500	35612-35615	CC	denotes	and
T6501	35616-35621	PRP$	denotes	their
T6502	35622-35627	NN	denotes	water
T6504	35628-35631	VBD	denotes	was
T6503	35632-35641	VBN	denotes	acidified
T6505	35642-35644	IN	denotes	to
T6506	35645-35647	NN	denotes	pH
T6507	35648-35651	CD	denotes	2.8
T6509	35652-35654	IN	denotes	to
T6508	35655-35658	CD	denotes	3.2
T6510	35658-35659	.	denotes	.
T6511	35659-35738	sentence	denotes	B6 mice develop diet induced diabetes when maintained on a high fat diet [76].
T6512	35660-35662	NN	denotes	B6
T6513	35663-35667	NNS	denotes	mice
T6514	35668-35675	VBP	denotes	develop
T6515	35676-35680	NN	denotes	diet
T6516	35681-35688	VBN	denotes	induced
T6517	35689-35697	NN	denotes	diabetes
T6518	35698-35702	WRB	denotes	when
T6519	35703-35713	VBN	denotes	maintained
T6520	35714-35716	IN	denotes	on
T6521	35717-35718	DT	denotes	a
T6523	35719-35723	JJ	denotes	high
T6524	35724-35727	NN	denotes	fat
T6522	35728-35732	NN	denotes	diet
T6525	35733-35734	-LRB-	denotes	[
T6526	35734-35736	CD	denotes	76
T6527	35736-35737	-RRB-	denotes	]
T6528	35737-35738	.	denotes	.
T6529	35738-35873	sentence	denotes	To ensure that we were analyzing the effect of age and not diabetes, the B6 mice in the aging experiment were fed NIH31 (4% fat) chow.
T6530	35739-35741	TO	denotes	To
T6531	35742-35748	VB	denotes	ensure
T6533	35749-35753	IN	denotes	that
T6535	35754-35756	PRP	denotes	we
T6536	35757-35761	VBD	denotes	were
T6534	35762-35771	VBG	denotes	analyzing
T6537	35772-35775	DT	denotes	the
T6538	35776-35782	NN	denotes	effect
T6539	35783-35785	IN	denotes	of
T6540	35786-35789	NN	denotes	age
T6541	35790-35793	CC	denotes	and
T6542	35794-35797	RB	denotes	not
T6543	35798-35806	NN	denotes	diabetes
T6544	35806-35808	,	denotes	,
T6545	35808-35811	DT	denotes	the
T6547	35812-35814	NN	denotes	B6
T6546	35815-35819	NNS	denotes	mice
T6548	35820-35822	IN	denotes	in
T6549	35823-35826	DT	denotes	the
T6551	35827-35832	NN	denotes	aging
T6550	35833-35843	NN	denotes	experiment
T6552	35844-35848	VBD	denotes	were
T6532	35849-35852	VBN	denotes	fed
T6553	35853-35858	NN	denotes	NIH31
T6555	35859-35860	-LRB-	denotes	(
T6556	35860-35861	CD	denotes	4
T6557	35861-35862	NN	denotes	%
T6558	35863-35866	NN	denotes	fat
T6559	35866-35867	-RRB-	denotes	)
T6554	35868-35872	NN	denotes	chow
T6560	35872-35873	.	denotes	.
T6561	35873-36000	sentence	denotes	We have found no differences in IOP between B6 mice housed on the 4% fat and 6% fat versions of this otherwise identical diet.
T6562	35874-35876	PRP	denotes	We
T6564	35877-35881	VBP	denotes	have
T6563	35882-35887	VBN	denotes	found
T6565	35888-35890	DT	denotes	no
T6566	35891-35902	NNS	denotes	differences
T6567	35903-35905	IN	denotes	in
T6568	35906-35909	NN	denotes	IOP
T6569	35910-35917	IN	denotes	between
T6570	35918-35920	NN	denotes	B6
T6571	35921-35925	NNS	denotes	mice
T6572	35926-35932	VBN	denotes	housed
T6573	35933-35935	IN	denotes	on
T6574	35936-35939	DT	denotes	the
T6576	35940-35941	CD	denotes	4
T6577	35941-35942	NN	denotes	%
T6578	35943-35946	NN	denotes	fat
T6579	35947-35950	CC	denotes	and
T6580	35951-35952	CD	denotes	6
T6581	35952-35953	NN	denotes	%
T6582	35954-35957	NN	denotes	fat
T6575	35958-35966	NNS	denotes	versions
T6583	35967-35969	IN	denotes	of
T6584	35970-35974	DT	denotes	this
T6586	35975-35984	RB	denotes	otherwise
T6587	35985-35994	JJ	denotes	identical
T6585	35995-35999	NN	denotes	diet
T6588	35999-36000	.	denotes	.
T6589	36000-36073	sentence	denotes	The mice were group housed and the cages were changed one time per week.
T6590	36001-36004	DT	denotes	The
T6591	36005-36009	NNS	denotes	mice
T6593	36010-36014	VBD	denotes	were
T6594	36015-36020	NN	denotes	group
T6592	36021-36027	VBN	denotes	housed
T6595	36028-36031	CC	denotes	and
T6596	36032-36035	DT	denotes	the
T6597	36036-36041	NNS	denotes	cages
T6599	36042-36046	VBD	denotes	were
T6598	36047-36054	VBN	denotes	changed
T6600	36055-36058	CD	denotes	one
T6601	36059-36063	NN	denotes	time
T6602	36064-36067	IN	denotes	per
T6603	36068-36072	NN	denotes	week
T6604	36072-36073	.	denotes	.
T6605	36073-36166	sentence	denotes	If any cage appeared soiled between scheduled changes, the mice were placed in a clean cage.
T6606	36074-36076	IN	denotes	If
T6608	36077-36080	DT	denotes	any
T6609	36081-36085	NN	denotes	cage
T6607	36086-36094	VBD	denotes	appeared
T6611	36095-36101	JJ	denotes	soiled
T6612	36102-36109	IN	denotes	between
T6613	36110-36119	JJ	denotes	scheduled
T6614	36120-36127	NNS	denotes	changes
T6615	36127-36129	,	denotes	,
T6616	36129-36132	DT	denotes	the
T6617	36133-36137	NNS	denotes	mice
T6618	36138-36142	VBD	denotes	were
T6610	36143-36149	VBN	denotes	placed
T6619	36150-36152	IN	denotes	in
T6620	36153-36154	DT	denotes	a
T6622	36155-36160	JJ	denotes	clean
T6621	36161-36165	NN	denotes	cage
T6623	36165-36166	.	denotes	.
T6624	36166-36241	sentence	denotes	The environment was kept at 21°C with a 14 hour light: 10 hour dark cycle.
T6625	36167-36170	DT	denotes	The
T6626	36171-36182	NN	denotes	environment
T6628	36183-36186	VBD	denotes	was
T6627	36187-36191	VBN	denotes	kept
T6629	36192-36194	IN	denotes	at
T6630	36195-36197	CD	denotes	21
T6631	36197-36199	NNS	denotes	°C
T6632	36200-36204	IN	denotes	with
T6633	36205-36206	DT	denotes	a
T6635	36207-36209	CD	denotes	14
T6636	36210-36214	NN	denotes	hour
T6637	36215-36220	NN	denotes	light
T6638	36220-36222	SYM	denotes	:
T6640	36222-36224	CD	denotes	10
T6641	36225-36229	NN	denotes	hour
T6639	36230-36234	JJ	denotes	dark
T6634	36235-36240	NN	denotes	cycle
T6642	36240-36241	.	denotes	.
T6643	36241-36377	sentence	denotes	The colony was monitored for specific pathogens by The Jackson Laboratory's routine surveillance program (see for specific pathogens).
T6644	36242-36245	DT	denotes	The
T6645	36246-36252	NN	denotes	colony
T6647	36253-36256	VBD	denotes	was
T6646	36257-36266	VBN	denotes	monitored
T6648	36267-36270	IN	denotes	for
T6649	36271-36279	JJ	denotes	specific
T6650	36280-36289	NNS	denotes	pathogens
T6651	36290-36292	IN	denotes	by
T6652	36293-36296	DT	denotes	The
T6654	36297-36304	NNP	denotes	Jackson
T6653	36305-36315	NNP	denotes	Laboratory
T6656	36315-36317	POS	denotes	's
T6657	36318-36325	JJ	denotes	routine
T6658	36326-36338	NN	denotes	surveillance
T6655	36339-36346	NN	denotes	program
T6659	36347-36348	-LRB-	denotes	(
T6660	36348-36351	VB	denotes	see
T6661	36353-36356	IN	denotes	for
T6662	36357-36365	JJ	denotes	specific
T6663	36366-36375	NNS	denotes	pathogens
T6664	36375-36376	-RRB-	denotes	)
T6665	36376-36377	.	denotes	.
T6722	36379-36390	JJ	denotes	Intraocular
T6723	36391-36399	NN	denotes	pressure
T6724	36399-36467	sentence	denotes	Intraocular pressures were measured as described elsewhere [13,77].
T6725	36400-36411	JJ	denotes	Intraocular
T6726	36412-36421	NNS	denotes	pressures
T6728	36422-36426	VBD	denotes	were
T6727	36427-36435	VBN	denotes	measured
T6729	36436-36438	IN	denotes	as
T6730	36439-36448	VBN	denotes	described
T6731	36449-36458	RB	denotes	elsewhere
T6732	36459-36460	-LRB-	denotes	[
T6734	36460-36462	CD	denotes	13
T6735	36462-36463	,	denotes	,
T6733	36463-36465	CD	denotes	77
T6736	36465-36466	-RRB-	denotes	]
T6737	36466-36467	.	denotes	.
T6738	36467-36606	sentence	denotes	The mice were typically acclimatized to the procedure room for at least 2 weeks prior to measurement, but sometimes between 1 and 2 weeks.
T6739	36468-36471	DT	denotes	The
T6740	36472-36476	NNS	denotes	mice
T6742	36477-36481	VBD	denotes	were
T6743	36482-36491	RB	denotes	typically
T6741	36492-36504	VBN	denotes	acclimatized
T6744	36505-36507	IN	denotes	to
T6745	36508-36511	DT	denotes	the
T6747	36512-36521	NN	denotes	procedure
T6746	36522-36526	NN	denotes	room
T6748	36527-36530	IN	denotes	for
T6749	36531-36533	RB	denotes	at
T6751	36534-36539	RBS	denotes	least
T6750	36540-36541	CD	denotes	2
T6752	36542-36547	NNS	denotes	weeks
T6753	36548-36553	RB	denotes	prior
T6754	36554-36556	IN	denotes	to
T6755	36557-36568	NN	denotes	measurement
T6756	36568-36570	,	denotes	,
T6757	36570-36573	CC	denotes	but
T6758	36574-36583	RB	denotes	sometimes
T6760	36584-36591	IN	denotes	between
T6761	36592-36593	CD	denotes	1
T6762	36594-36597	CC	denotes	and
T6763	36598-36599	CD	denotes	2
T6759	36600-36605	NNS	denotes	weeks
T6764	36605-36606	.	denotes	.
T6765	36606-36729	sentence	denotes	Although it was not possible to include all strains in each measurement period, mice of different strains were intermixed.
T6766	36607-36615	IN	denotes	Although
T6768	36616-36618	PRP	denotes	it
T6767	36619-36622	VBD	denotes	was
T6770	36623-36626	RB	denotes	not
T6771	36627-36635	JJ	denotes	possible
T6772	36636-36638	TO	denotes	to
T6773	36639-36646	VB	denotes	include
T6774	36647-36650	DT	denotes	all
T6775	36651-36658	NNS	denotes	strains
T6776	36659-36661	IN	denotes	in
T6777	36662-36666	DT	denotes	each
T6779	36667-36678	NN	denotes	measurement
T6778	36679-36685	NN	denotes	period
T6780	36685-36687	,	denotes	,
T6781	36687-36691	NNS	denotes	mice
T6782	36692-36694	IN	denotes	of
T6783	36695-36704	JJ	denotes	different
T6784	36705-36712	NNS	denotes	strains
T6785	36713-36717	VBD	denotes	were
T6769	36718-36728	VBN	denotes	intermixed
T6786	36728-36729	.	denotes	.
T6787	36729-36977	sentence	denotes	As demonstrated here, the IOPs of C57BL/6J are very consistent over time and so these animals were interspersed with experimental mice during all experiments to ensure that calibration had not drifted and that the system was functioning optimally.
T6788	36730-36732	IN	denotes	As
T6789	36733-36745	VBN	denotes	demonstrated
T6791	36746-36750	RB	denotes	here
T6792	36750-36752	,	denotes	,
T6793	36752-36755	DT	denotes	the
T6794	36756-36760	NNS	denotes	IOPs
T6795	36761-36763	IN	denotes	of
T6796	36764-36769	NN	denotes	C57BL
T6798	36769-36770	HYPH	denotes	/
T6797	36770-36772	NN	denotes	6J
T6790	36773-36776	VBP	denotes	are
T6799	36777-36781	RB	denotes	very
T6800	36782-36792	JJ	denotes	consistent
T6801	36793-36797	IN	denotes	over
T6802	36798-36802	NN	denotes	time
T6803	36803-36806	CC	denotes	and
T6804	36807-36809	RB	denotes	so
T6805	36810-36815	DT	denotes	these
T6806	36816-36823	NNS	denotes	animals
T6808	36824-36828	VBD	denotes	were
T6807	36829-36841	VBN	denotes	interspersed
T6809	36842-36846	IN	denotes	with
T6810	36847-36859	JJ	denotes	experimental
T6811	36860-36864	NNS	denotes	mice
T6812	36865-36871	IN	denotes	during
T6813	36872-36875	DT	denotes	all
T6814	36876-36887	NNS	denotes	experiments
T6815	36888-36890	TO	denotes	to
T6816	36891-36897	VB	denotes	ensure
T6817	36898-36902	IN	denotes	that
T6819	36903-36914	NN	denotes	calibration
T6820	36915-36918	VBD	denotes	had
T6821	36919-36922	RB	denotes	not
T6818	36923-36930	VBN	denotes	drifted
T6822	36931-36934	CC	denotes	and
T6823	36935-36939	IN	denotes	that
T6825	36940-36943	DT	denotes	the
T6826	36944-36950	NN	denotes	system
T6827	36951-36954	VBD	denotes	was
T6824	36955-36966	VBG	denotes	functioning
T6828	36967-36976	RB	denotes	optimally
T6829	36976-36977	.	denotes	.
T6830	36977-37070	sentence	denotes	Whenever possible, the investigator measuring IOP did not know the genotypes of the animals.
T6831	36978-36986	WRB	denotes	Whenever
T6832	36987-36995	JJ	denotes	possible
T6834	36995-36997	,	denotes	,
T6835	36997-37000	DT	denotes	the
T6836	37001-37013	NN	denotes	investigator
T6837	37014-37023	VBG	denotes	measuring
T6838	37024-37027	NN	denotes	IOP
T6839	37028-37031	VBD	denotes	did
T6840	37032-37035	RB	denotes	not
T6833	37036-37040	VB	denotes	know
T6841	37041-37044	DT	denotes	the
T6842	37045-37054	NNS	denotes	genotypes
T6843	37055-37057	IN	denotes	of
T6844	37058-37061	DT	denotes	the
T6845	37062-37069	NNS	denotes	animals
T6846	37069-37070	.	denotes	.
T6847	37070-37174	sentence	denotes	It was not possible to analyze all age groups of each strain at the same time in the aging experiments.
T6848	37071-37073	PRP	denotes	It
T6849	37074-37077	VBD	denotes	was
T6850	37078-37081	RB	denotes	not
T6851	37082-37090	JJ	denotes	possible
T6852	37091-37093	TO	denotes	to
T6853	37094-37101	VB	denotes	analyze
T6854	37102-37105	DT	denotes	all
T6856	37106-37109	NN	denotes	age
T6855	37110-37116	NNS	denotes	groups
T6857	37117-37119	IN	denotes	of
T6858	37120-37124	DT	denotes	each
T6859	37125-37131	NN	denotes	strain
T6860	37132-37134	IN	denotes	at
T6861	37135-37138	DT	denotes	the
T6863	37139-37143	JJ	denotes	same
T6862	37144-37148	NN	denotes	time
T6864	37149-37151	IN	denotes	in
T6865	37152-37155	DT	denotes	the
T6867	37156-37161	NN	denotes	aging
T6866	37162-37173	NNS	denotes	experiments
T6868	37173-37174	.	denotes	.
T6869	37174-37343	sentence	denotes	Therefore, to control for potential IOP changes due to measurement time and not age, approximately 3 month old B6 mice were assessed at the same time as each age group.
T6870	37175-37184	RB	denotes	Therefore
T6872	37184-37186	,	denotes	,
T6873	37186-37188	TO	denotes	to
T6874	37189-37196	VB	denotes	control
T6875	37197-37200	IN	denotes	for
T6876	37201-37210	JJ	denotes	potential
T6878	37211-37214	NN	denotes	IOP
T6877	37215-37222	NNS	denotes	changes
T6879	37223-37226	IN	denotes	due
T6880	37227-37229	IN	denotes	to
T6881	37230-37241	NN	denotes	measurement
T6882	37242-37246	NN	denotes	time
T6883	37247-37250	CC	denotes	and
T6884	37251-37254	RB	denotes	not
T6885	37255-37258	NN	denotes	age
T6886	37258-37260	,	denotes	,
T6887	37260-37273	RB	denotes	approximately
T6888	37274-37275	CD	denotes	3
T6889	37276-37281	NN	denotes	month
T6890	37282-37285	JJ	denotes	old
T6892	37286-37288	NN	denotes	B6
T6891	37289-37293	NNS	denotes	mice
T6893	37294-37298	VBD	denotes	were
T6871	37299-37307	VBN	denotes	assessed
T6894	37308-37310	IN	denotes	at
T6895	37311-37314	DT	denotes	the
T6897	37315-37319	JJ	denotes	same
T6896	37320-37324	NN	denotes	time
T6898	37325-37327	IN	denotes	as
T6899	37328-37332	DT	denotes	each
T6901	37333-37336	NN	denotes	age
T6900	37337-37342	NN	denotes	group
T6902	37342-37343	.	denotes	.
T6903	37343-37433	sentence	denotes	All dark period measurements were made between 1 and 3 hours after the lights turned off.
T6904	37344-37347	DT	denotes	All
T6906	37348-37352	JJ	denotes	dark
T6907	37353-37359	NN	denotes	period
T6905	37360-37372	NNS	denotes	measurements
T6909	37373-37377	VBD	denotes	were
T6908	37378-37382	VBN	denotes	made
T6910	37383-37390	IN	denotes	between
T6911	37391-37392	CD	denotes	1
T6913	37393-37396	CC	denotes	and
T6914	37397-37398	CD	denotes	3
T6912	37399-37404	NNS	denotes	hours
T6916	37405-37410	IN	denotes	after
T6917	37411-37414	DT	denotes	the
T6918	37415-37421	NNS	denotes	lights
T6915	37422-37428	VBD	denotes	turned
T6919	37429-37432	RP	denotes	off
T6920	37432-37433	.	denotes	.
T6921	37433-37538	sentence	denotes	The room was equipped with dim red lights and mice were protected from all light exposure during set up.
T6922	37434-37437	DT	denotes	The
T6923	37438-37442	NN	denotes	room
T6925	37443-37446	VBD	denotes	was
T6924	37447-37455	VBN	denotes	equipped
T6926	37456-37460	IN	denotes	with
T6927	37461-37464	NN	denotes	dim
T6929	37465-37468	JJ	denotes	red
T6928	37469-37475	NNS	denotes	lights
T6930	37476-37479	CC	denotes	and
T6931	37480-37484	NNS	denotes	mice
T6933	37485-37489	VBD	denotes	were
T6932	37490-37499	VBN	denotes	protected
T6934	37500-37504	IN	denotes	from
T6935	37505-37508	DT	denotes	all
T6937	37509-37514	JJ	denotes	light
T6936	37515-37523	NN	denotes	exposure
T6938	37524-37530	IN	denotes	during
T6939	37531-37534	NN	denotes	set
T6940	37535-37537	NN	denotes	up
T6941	37537-37538	.	denotes	.
T6942	37538-37632	sentence	denotes	Each mouse was briefly exposed to the red light when the anesthetic agents were administered.
T6943	37539-37543	DT	denotes	Each
T6944	37544-37549	NN	denotes	mouse
T6946	37550-37553	VBD	denotes	was
T6947	37554-37561	RB	denotes	briefly
T6945	37562-37569	VBN	denotes	exposed
T6948	37570-37572	IN	denotes	to
T6949	37573-37576	DT	denotes	the
T6951	37577-37580	JJ	denotes	red
T6950	37581-37586	NN	denotes	light
T6952	37587-37591	WRB	denotes	when
T6954	37592-37595	DT	denotes	the
T6956	37596-37606	JJ	denotes	anesthetic
T6955	37607-37613	NNS	denotes	agents
T6957	37614-37618	VBD	denotes	were
T6953	37619-37631	VBN	denotes	administered
T6958	37631-37632	.	denotes	.
T6959	37632-37950	sentence	denotes	When adequate anesthesia was achieved (after 3 to 4 minutes), the mouse was placed on the measurement platform and the white light of the microscope was turned on (for approximately 1 and a half minutes) to allow ocular cannulation, IOP measurement and post-measurement tests [13] that guard against artifactual data.
T6960	37633-37637	WRB	denotes	When
T6962	37638-37646	JJ	denotes	adequate
T6963	37647-37657	NN	denotes	anesthesia
T6964	37658-37661	VBD	denotes	was
T6961	37662-37670	VBN	denotes	achieved
T6966	37671-37672	-LRB-	denotes	(
T6967	37672-37677	IN	denotes	after
T6968	37678-37679	CD	denotes	3
T6970	37680-37682	IN	denotes	to
T6969	37683-37684	CD	denotes	4
T6971	37685-37692	NNS	denotes	minutes
T6972	37692-37693	-RRB-	denotes	)
T6973	37693-37695	,	denotes	,
T6974	37695-37698	DT	denotes	the
T6975	37699-37704	NN	denotes	mouse
T6976	37705-37708	VBD	denotes	was
T6965	37709-37715	VBN	denotes	placed
T6977	37716-37718	IN	denotes	on
T6978	37719-37722	DT	denotes	the
T6980	37723-37734	NN	denotes	measurement
T6979	37735-37743	NN	denotes	platform
T6981	37744-37747	CC	denotes	and
T6982	37748-37751	DT	denotes	the
T6984	37752-37757	JJ	denotes	white
T6983	37758-37763	NN	denotes	light
T6986	37764-37766	IN	denotes	of
T6987	37767-37770	DT	denotes	the
T6988	37771-37781	NN	denotes	microscope
T6989	37782-37785	VBD	denotes	was
T6985	37786-37792	VBN	denotes	turned
T6990	37793-37795	RP	denotes	on
T6991	37796-37797	-LRB-	denotes	(
T6992	37797-37800	IN	denotes	for
T6993	37801-37814	RB	denotes	approximately
T6994	37815-37816	CD	denotes	1
T6996	37817-37820	CC	denotes	and
T6997	37821-37822	DT	denotes	a
T6998	37823-37827	JJ	denotes	half
T6995	37828-37835	NNS	denotes	minutes
T6999	37835-37836	-RRB-	denotes	)
T7000	37837-37839	TO	denotes	to
T7001	37840-37845	VB	denotes	allow
T7002	37846-37852	JJ	denotes	ocular
T7003	37853-37864	NN	denotes	cannulation
T7004	37864-37866	,	denotes	,
T7005	37866-37869	NN	denotes	IOP
T7006	37870-37881	NN	denotes	measurement
T7008	37882-37885	CC	denotes	and
T7009	37886-37902	NN	denotes	post-measurement
T7007	37903-37908	NNS	denotes	tests
T7010	37909-37910	-LRB-	denotes	[
T7011	37910-37912	CD	denotes	13
T7012	37912-37913	-RRB-	denotes	]
T7013	37914-37918	WDT	denotes	that
T7014	37919-37924	VBP	denotes	guard
T7015	37925-37932	IN	denotes	against
T7016	37933-37944	JJ	denotes	artifactual
T7017	37945-37949	NNS	denotes	data
T7018	37949-37950	.	denotes	.
T7019	37950-38090	sentence	denotes	The white light was used at very low intensity and was dim but we cannot rule out the possibility that this brief exposure altered the IOP.
T7020	37951-37954	DT	denotes	The
T7022	37955-37960	JJ	denotes	white
T7021	37961-37966	NN	denotes	light
T7024	37967-37970	VBD	denotes	was
T7023	37971-37975	VBN	denotes	used
T7025	37976-37978	IN	denotes	at
T7026	37979-37983	RB	denotes	very
T7027	37984-37987	JJ	denotes	low
T7028	37988-37997	NN	denotes	intensity
T7029	37998-38001	CC	denotes	and
T7030	38002-38005	VBD	denotes	was
T7031	38006-38009	JJ	denotes	dim
T7032	38010-38013	CC	denotes	but
T7033	38014-38016	PRP	denotes	we
T7035	38017-38020	MD	denotes	can
T7036	38020-38023	RB	denotes	not
T7034	38024-38028	VB	denotes	rule
T7037	38029-38032	RP	denotes	out
T7038	38033-38036	DT	denotes	the
T7039	38037-38048	NN	denotes	possibility
T7040	38049-38053	IN	denotes	that
T7042	38054-38058	DT	denotes	this
T7044	38059-38064	JJ	denotes	brief
T7043	38065-38073	NN	denotes	exposure
T7041	38074-38081	VBD	denotes	altered
T7045	38082-38085	DT	denotes	the
T7046	38086-38089	NN	denotes	IOP
T7047	38089-38090	.	denotes	.
T7048	38090-38194	sentence	denotes	All other mice were protected from light exposure throughout the time an individual mouse was analyzed.
T7049	38091-38094	DT	denotes	All
T7051	38095-38100	JJ	denotes	other
T7050	38101-38105	NNS	denotes	mice
T7053	38106-38110	VBD	denotes	were
T7052	38111-38120	VBN	denotes	protected
T7054	38121-38125	IN	denotes	from
T7055	38126-38131	JJ	denotes	light
T7056	38132-38140	NN	denotes	exposure
T7057	38141-38151	IN	denotes	throughout
T7058	38152-38155	DT	denotes	the
T7059	38156-38160	NN	denotes	time
T7060	38161-38163	DT	denotes	an
T7062	38164-38174	JJ	denotes	individual
T7061	38175-38180	NN	denotes	mouse
T7064	38181-38184	VBD	denotes	was
T7063	38185-38193	VBN	denotes	analyzed
T7065	38193-38194	.	denotes	.
T7102	38196-38201	NN	denotes	Blood
T7103	38202-38210	NN	denotes	pressure
T7104	38210-38390	sentence	denotes	The blood pressures of conscious mice of each strain (6 to 12 females per strain) were measured with a tail-cuff system as reported [78], except that 5 days of training were used.
T7105	38211-38214	DT	denotes	The
T7107	38215-38220	NN	denotes	blood
T7106	38221-38230	NNS	denotes	pressures
T7109	38231-38233	IN	denotes	of
T7110	38234-38243	JJ	denotes	conscious
T7111	38244-38248	NNS	denotes	mice
T7112	38249-38251	IN	denotes	of
T7113	38252-38256	DT	denotes	each
T7114	38257-38263	NN	denotes	strain
T7115	38264-38265	-LRB-	denotes	(
T7116	38265-38266	CD	denotes	6
T7118	38267-38269	IN	denotes	to
T7117	38270-38272	CD	denotes	12
T7119	38273-38280	NNS	denotes	females
T7120	38281-38284	IN	denotes	per
T7121	38285-38291	NN	denotes	strain
T7122	38291-38292	-RRB-	denotes	)
T7123	38293-38297	VBD	denotes	were
T7108	38298-38306	VBN	denotes	measured
T7124	38307-38311	IN	denotes	with
T7125	38312-38313	DT	denotes	a
T7127	38314-38318	NN	denotes	tail
T7129	38318-38319	HYPH	denotes	-
T7128	38319-38323	NN	denotes	cuff
T7126	38324-38330	NN	denotes	system
T7130	38331-38333	IN	denotes	as
T7131	38334-38342	VBN	denotes	reported
T7132	38343-38344	-LRB-	denotes	[
T7133	38344-38346	CD	denotes	78
T7134	38346-38347	-RRB-	denotes	]
T7135	38347-38349	,	denotes	,
T7136	38349-38355	IN	denotes	except
T7137	38356-38360	IN	denotes	that
T7139	38361-38362	CD	denotes	5
T7140	38363-38367	NNS	denotes	days
T7141	38368-38370	IN	denotes	of
T7142	38371-38379	NN	denotes	training
T7143	38380-38384	VBD	denotes	were
T7138	38385-38389	VBN	denotes	used
T7144	38389-38390	.	denotes	.
T7145	38390-38472	sentence	denotes	The mice were analyzed in the same procedure room as was used for IOP measurment.
T7146	38391-38394	DT	denotes	The
T7147	38395-38399	NNS	denotes	mice
T7149	38400-38404	VBD	denotes	were
T7148	38405-38413	VBN	denotes	analyzed
T7150	38414-38416	IN	denotes	in
T7151	38417-38420	DT	denotes	the
T7153	38421-38425	JJ	denotes	same
T7154	38426-38435	NN	denotes	procedure
T7152	38436-38440	NN	denotes	room
T7155	38441-38443	IN	denotes	as
T7157	38444-38447	VBD	denotes	was
T7156	38448-38452	VBN	denotes	used
T7158	38453-38456	IN	denotes	for
T7159	38457-38460	NN	denotes	IOP
T7160	38461-38471	NN	denotes	measurment
T7161	38471-38472	.	denotes	.
T7175	38474-38482	JJ	denotes	Clinical
T7176	38483-38495	NNS	denotes	examinations
T7177	38495-38582	sentence	denotes	For most strains, anterior chambers were examined with a slit lamp biomicroscope [16].
T7178	38496-38499	IN	denotes	For
T7180	38500-38504	JJS	denotes	most
T7181	38505-38512	NNS	denotes	strains
T7182	38512-38514	,	denotes	,
T7183	38514-38522	JJ	denotes	anterior
T7184	38523-38531	NNS	denotes	chambers
T7185	38532-38536	VBD	denotes	were
T7179	38537-38545	VBN	denotes	examined
T7186	38546-38550	IN	denotes	with
T7187	38551-38552	DT	denotes	a
T7189	38553-38557	JJ	denotes	slit
T7190	38558-38562	NN	denotes	lamp
T7188	38563-38576	NN	denotes	biomicroscope
T7191	38577-38578	-LRB-	denotes	[
T7192	38578-38580	CD	denotes	16
T7193	38580-38581	-RRB-	denotes	]
T7194	38581-38582	.	denotes	.
T7195	38582-38647	sentence	denotes	At least 8 mice of each strain shown in figure 1 were evaluated.
T7196	38583-38585	RB	denotes	At
T7198	38586-38591	RBS	denotes	least
T7197	38592-38593	CD	denotes	8
T7199	38594-38598	NNS	denotes	mice
T7201	38599-38601	IN	denotes	of
T7202	38602-38606	DT	denotes	each
T7203	38607-38613	NN	denotes	strain
T7204	38614-38619	VBN	denotes	shown
T7205	38620-38622	IN	denotes	in
T7206	38623-38629	NN	denotes	figure
T7207	38630-38631	CD	denotes	1
T7208	38632-38636	VBD	denotes	were
T7200	38637-38646	VBN	denotes	evaluated
T7209	38646-38647	.	denotes	.
T7210	38647-38778	sentence	denotes	However, the anterior chambers of C57BLKS/J mice were only evaluated under a dissection microscope at the time of IOP measurement.
T7211	38648-38655	RB	denotes	However
T7213	38655-38657	,	denotes	,
T7214	38657-38660	DT	denotes	the
T7216	38661-38669	JJ	denotes	anterior
T7215	38670-38678	NNS	denotes	chambers
T7217	38679-38681	IN	denotes	of
T7218	38682-38689	NN	denotes	C57BLKS
T7220	38689-38690	HYPH	denotes	/
T7219	38690-38691	NN	denotes	J
T7221	38692-38696	NNS	denotes	mice
T7222	38697-38701	VBD	denotes	were
T7223	38702-38706	RB	denotes	only
T7212	38707-38716	VBN	denotes	evaluated
T7224	38717-38722	IN	denotes	under
T7225	38723-38724	DT	denotes	a
T7227	38725-38735	NN	denotes	dissection
T7226	38736-38746	NN	denotes	microscope
T7228	38747-38749	IN	denotes	at
T7229	38750-38753	DT	denotes	the
T7230	38754-38758	NN	denotes	time
T7231	38759-38761	IN	denotes	of
T7232	38762-38765	NN	denotes	IOP
T7233	38766-38777	NN	denotes	measurement
T7234	38777-38778	.	denotes	.
T7250	38780-38792	JJ	denotes	Histological
T7251	38793-38801	NN	denotes	analysis
T7252	38801-39075	sentence	denotes	Eyes from at least 2 mice of the listed strains were fixed (4% paraformaldehyde or Fekete's acid-alcohol-formalin fixative) processed, paraffin embedded and sectioned as previously reported [15,79], except that the paraformaldehyde was buffered with 0.1 M phosphate buffer.
T7253	38802-38806	NNS	denotes	Eyes
T7255	38807-38811	IN	denotes	from
T7256	38812-38814	RB	denotes	at
T7258	38815-38820	RBS	denotes	least
T7257	38821-38822	CD	denotes	2
T7259	38823-38827	NNS	denotes	mice
T7260	38828-38830	IN	denotes	of
T7261	38831-38834	DT	denotes	the
T7263	38835-38841	VBN	denotes	listed
T7262	38842-38849	NNS	denotes	strains
T7264	38850-38854	VBD	denotes	were
T7254	38855-38860	VBN	denotes	fixed
T7265	38861-38862	-LRB-	denotes	(
T7267	38862-38863	CD	denotes	4
T7268	38863-38864	NN	denotes	%
T7266	38865-38881	NN	denotes	paraformaldehyde
T7269	38882-38884	CC	denotes	or
T7270	38885-38891	NNP	denotes	Fekete
T7272	38891-38893	POS	denotes	's
T7273	38894-38898	NN	denotes	acid
T7275	38898-38899	HYPH	denotes	-
T7276	38899-38906	NN	denotes	alcohol
T7277	38906-38907	HYPH	denotes	-
T7274	38907-38915	NN	denotes	formalin
T7271	38916-38924	NN	denotes	fixative
T7278	38924-38925	-RRB-	denotes	)
T7279	38926-38935	VBN	denotes	processed
T7280	38935-38937	,	denotes	,
T7281	38937-38945	NN	denotes	paraffin
T7282	38946-38954	VBN	denotes	embedded
T7283	38955-38958	CC	denotes	and
T7284	38959-38968	VBN	denotes	sectioned
T7285	38969-38971	IN	denotes	as
T7287	38972-38982	RB	denotes	previously
T7286	38983-38991	VBN	denotes	reported
T7288	38992-38993	-LRB-	denotes	[
T7290	38993-38995	CD	denotes	15
T7291	38995-38996	,	denotes	,
T7289	38996-38998	CD	denotes	79
T7292	38998-38999	-RRB-	denotes	]
T7293	38999-39001	,	denotes	,
T7294	39001-39007	IN	denotes	except
T7295	39008-39012	IN	denotes	that
T7297	39013-39016	DT	denotes	the
T7298	39017-39033	NN	denotes	paraformaldehyde
T7299	39034-39037	VBD	denotes	was
T7296	39038-39046	VBN	denotes	buffered
T7300	39047-39051	IN	denotes	with
T7301	39052-39055	CD	denotes	0.1
T7302	39056-39057	NN	denotes	M
T7303	39058-39067	NN	denotes	phosphate
T7304	39068-39074	NN	denotes	buffer
T7305	39074-39075	.	denotes	.
T7306	39075-39145	sentence	denotes	All strains other than CBA/CaHN and C57BLKS/J strains were evaluated.
T7307	39076-39079	DT	denotes	All
T7308	39080-39087	NNS	denotes	strains
T7310	39088-39093	JJ	denotes	other
T7311	39094-39098	IN	denotes	than
T7312	39099-39102	NN	denotes	CBA
T7314	39102-39103	HYPH	denotes	/
T7313	39103-39107	NN	denotes	CaHN
T7316	39108-39111	CC	denotes	and
T7317	39112-39119	NN	denotes	C57BLKS
T7319	39119-39120	HYPH	denotes	/
T7318	39120-39121	NN	denotes	J
T7315	39122-39129	NNS	denotes	strains
T7320	39130-39134	VBD	denotes	were
T7309	39135-39144	VBN	denotes	evaluated
T7321	39144-39145	.	denotes	.
T7322	39145-39322	sentence	denotes	The eyes of CBA/CaJ and BALB/cJ mice were also fixed and processed for plastic embedding (Historesin, Leica, Heidelberg, Germany), and sectioned as previously reported [14,79].
T7323	39146-39149	DT	denotes	The
T7324	39150-39154	NNS	denotes	eyes
T7326	39155-39157	IN	denotes	of
T7327	39158-39161	NN	denotes	CBA
T7329	39161-39162	HYPH	denotes	/
T7328	39162-39165	NN	denotes	CaJ
T7331	39166-39169	CC	denotes	and
T7332	39170-39174	NN	denotes	BALB
T7334	39174-39175	HYPH	denotes	/
T7333	39175-39177	NN	denotes	cJ
T7330	39178-39182	NNS	denotes	mice
T7335	39183-39187	VBD	denotes	were
T7336	39188-39192	RB	denotes	also
T7325	39193-39198	VBN	denotes	fixed
T7337	39199-39202	CC	denotes	and
T7338	39203-39212	VBN	denotes	processed
T7339	39213-39216	IN	denotes	for
T7340	39217-39224	NN	denotes	plastic
T7341	39225-39234	NN	denotes	embedding
T7342	39235-39236	-LRB-	denotes	(
T7343	39236-39246	NNP	denotes	Historesin
T7344	39246-39248	,	denotes	,
T7345	39248-39253	NNP	denotes	Leica
T7346	39253-39255	,	denotes	,
T7347	39255-39265	NNP	denotes	Heidelberg
T7348	39265-39267	,	denotes	,
T7349	39267-39274	NNP	denotes	Germany
T7350	39274-39275	-RRB-	denotes	)
T7351	39275-39277	,	denotes	,
T7352	39277-39280	CC	denotes	and
T7353	39281-39290	VBN	denotes	sectioned
T7354	39291-39293	IN	denotes	as
T7356	39294-39304	RB	denotes	previously
T7355	39305-39313	VBN	denotes	reported
T7357	39314-39315	-LRB-	denotes	[
T7359	39315-39317	CD	denotes	14
T7360	39317-39318	,	denotes	,
T7358	39318-39320	CD	denotes	79
T7361	39320-39321	-RRB-	denotes	]
T7362	39321-39322	.	denotes	.
T7363	39322-39444	sentence	denotes	Saggital sections including the pupil and optic nerve were collected and analyzed as they contain most ocular structures.
T7364	39323-39331	JJ	denotes	Saggital
T7365	39332-39340	NNS	denotes	sections
T7367	39341-39350	VBG	denotes	including
T7368	39351-39354	DT	denotes	the
T7369	39355-39360	NN	denotes	pupil
T7370	39361-39364	CC	denotes	and
T7371	39365-39370	JJ	denotes	optic
T7372	39371-39376	NN	denotes	nerve
T7373	39377-39381	VBD	denotes	were
T7366	39382-39391	VBN	denotes	collected
T7374	39392-39395	CC	denotes	and
T7375	39396-39404	VBN	denotes	analyzed
T7376	39405-39407	IN	denotes	as
T7378	39408-39412	PRP	denotes	they
T7377	39413-39420	VBP	denotes	contain
T7379	39421-39425	JJS	denotes	most
T7381	39426-39432	JJ	denotes	ocular
T7380	39433-39443	NNS	denotes	structures
T7382	39443-39444	.	denotes	.
T7414	39446-39454	NN	denotes	Analysis
T7415	39455-39457	IN	denotes	of
T7416	39458-39462	NN	denotes	Myoc
T7417	39462-39600	sentence	denotes	Exons and the proximal promoter of the mouse Myoc gene were amplified from mouse genomic DNA using the following combinations of primers:
T7418	39463-39468	NNS	denotes	Exons
T7420	39469-39472	CC	denotes	and
T7421	39473-39476	DT	denotes	the
T7423	39477-39485	JJ	denotes	proximal
T7422	39486-39494	NN	denotes	promoter
T7424	39495-39497	IN	denotes	of
T7425	39498-39501	DT	denotes	the
T7427	39502-39507	NN	denotes	mouse
T7428	39508-39512	NN	denotes	Myoc
T7426	39513-39517	NN	denotes	gene
T7429	39518-39522	VBD	denotes	were
T7419	39523-39532	VBN	denotes	amplified
T7430	39533-39537	IN	denotes	from
T7431	39538-39543	NN	denotes	mouse
T7433	39544-39551	JJ	denotes	genomic
T7432	39552-39555	NN	denotes	DNA
T7434	39556-39561	VBG	denotes	using
T7435	39562-39565	DT	denotes	the
T7437	39566-39575	JJ	denotes	following
T7436	39576-39588	NNS	denotes	combinations
T7438	39589-39591	IN	denotes	of
T7439	39592-39599	NNS	denotes	primers
T7440	39599-39600	:	denotes	:
T7441	39600-39671	sentence	denotes	Exon 1: 5'-cttgcaggagaactttccagaa-3' and 5'-atctcgaaggagattgttatagg-3'
T7442	39601-39605	NN	denotes	Exon
T7444	39606-39607	CD	denotes	1
T7445	39607-39609	:	denotes	:
T7446	39609-39610	CD	denotes	5
T7447	39610-39611	SYM	denotes	'
T7453	39611-39612	HYPH	denotes	-
T7443	39612-39634	NN	denotes	cttgcaggagaactttccagaa
T7454	39634-39635	HYPH	denotes	-
T7455	39635-39636	CD	denotes	3
T7458	39636-39637	SYM	denotes	'
T7459	39638-39641	CC	denotes	and
T7462	39642-39643	CD	denotes	5
T7464	39643-39644	SYM	denotes	'
T7466	39644-39645	HYPH	denotes	-
T7463	39645-39668	NN	denotes	atctcgaaggagattgttatagg
T7467	39668-39669	HYPH	denotes	-
T7470	39669-39670	CD	denotes	3
T7472	39670-39671	SYM	denotes	'
T7475	39671-39733	sentence	denotes	5'-gaccagctggagacccaaaccag-3' and 5'-gctcagatccactgacctaaa-3'
T7476	39672-39673	CD	denotes	5
T7482	39673-39674	SYM	denotes	'
T7483	39674-39675	HYPH	denotes	-
T7478	39675-39698	NN	denotes	gaccagctggagacccaaaccag
T7484	39698-39699	HYPH	denotes	-
T7485	39699-39700	CD	denotes	3
T7486	39700-39701	SYM	denotes	'
T7487	39702-39705	CC	denotes	and
T7488	39706-39707	CD	denotes	5
T7490	39707-39708	SYM	denotes	'
T7491	39708-39709	HYPH	denotes	-
T7489	39709-39730	NN	denotes	gctcagatccactgacctaaa
T7492	39730-39731	HYPH	denotes	-
T7495	39731-39732	CD	denotes	3
T7496	39732-39733	SYM	denotes	'
T7497	39733-39804	sentence	denotes	Exon 2: 5'-tgaagccatactttaccaaccat-3' and 5'-caaaagggagaagtctaacttc-3'
T7498	39734-39738	NN	denotes	Exon
T7504	39739-39740	CD	denotes	2
T7505	39740-39742	:	denotes	:
T7506	39742-39743	CD	denotes	5
T7507	39743-39744	SYM	denotes	'
T7508	39744-39745	HYPH	denotes	-
T7503	39745-39768	NN	denotes	tgaagccatactttaccaaccat
T7509	39768-39769	HYPH	denotes	-
T7510	39769-39770	CD	denotes	3
T7448	39770-39771	SYM	denotes	'
T7449	39772-39775	CC	denotes	and
T7450	39776-39777	CD	denotes	5
T7452	39777-39778	SYM	denotes	'
T7456	39778-39779	HYPH	denotes	-
T7451	39779-39801	NN	denotes	caaaagggagaagtctaacttc
T7457	39801-39802	HYPH	denotes	-
T7460	39802-39803	CD	denotes	3
T7461	39803-39804	SYM	denotes	'
T7465	39804-39877	sentence	denotes	Exon 3: 5'-agtcaaggctcacagagctaa-3' and 5'-aagagtagctgctcaccgtgtacaag-3'
T7468	39805-39809	NN	denotes	Exon
T7471	39810-39811	CD	denotes	3
T7473	39811-39813	:	denotes	:
T7474	39813-39814	CD	denotes	5
T7477	39814-39815	SYM	denotes	'
T7479	39815-39816	HYPH	denotes	-
T7469	39816-39837	NN	denotes	agtcaaggctcacagagctaa
T7480	39837-39838	HYPH	denotes	-
T7481	39838-39839	CD	denotes	3
T7493	39839-39840	SYM	denotes	'
T7494	39841-39844	CC	denotes	and
T7499	39845-39846	CD	denotes	5
T7501	39846-39847	SYM	denotes	'
T7502	39847-39848	HYPH	denotes	-
T7500	39848-39874	NN	denotes	aagagtagctgctcaccgtgtacaag
T7511	39874-39875	HYPH	denotes	-
T7512	39875-39876	CD	denotes	3
T7513	39876-39877	SYM	denotes	'
T7514	39877-39938	sentence	denotes	5'-agacattgacttagctgtggat-3' and 5'-cggaacttcaccttttctggc-3'
T7515	39878-39879	CD	denotes	5
T7517	39879-39880	SYM	denotes	'
T7518	39880-39881	HYPH	denotes	-
T7516	39881-39903	NN	denotes	agacattgacttagctgtggat
T7519	39903-39904	HYPH	denotes	-
T7520	39904-39905	CD	denotes	3
T7521	39905-39906	SYM	denotes	'
T7522	39907-39910	CC	denotes	and
T7523	39911-39912	CD	denotes	5
T7525	39912-39913	SYM	denotes	'
T7526	39913-39914	HYPH	denotes	-
T7524	39914-39935	NN	denotes	cggaacttcaccttttctggc
T7527	39935-39936	HYPH	denotes	-
T7528	39936-39937	CD	denotes	3
T7529	39937-39938	SYM	denotes	'
T7530	39938-40010	sentence	denotes	Promoter: 5'-taggagaagtctcattatactgc-3' and 5'-ttcactggaccagcataagga-3'
T7531	39939-39947	NN	denotes	Promoter
T7533	39947-39949	:	denotes	:
T7534	39949-39950	CD	denotes	5
T7535	39950-39951	SYM	denotes	'
T7536	39951-39952	HYPH	denotes	-
T7532	39952-39975	NN	denotes	taggagaagtctcattatactgc
T7537	39975-39976	HYPH	denotes	-
T7538	39976-39977	CD	denotes	3
T7539	39977-39978	''	denotes	'
T7540	39979-39982	CC	denotes	and
T7541	39983-39984	CD	denotes	5
T7543	39984-39985	SYM	denotes	'
T7544	39985-39986	HYPH	denotes	-
T7542	39986-40007	NN	denotes	ttcactggaccagcataagga
T7545	40007-40008	HYPH	denotes	-
T7546	40008-40009	CD	denotes	3
T7547	40009-40010	SYM	denotes	'
T7548	40010-40073	sentence	denotes	5'-tctgaggatgttcacaggtttat-3' and 5'-tcttctggaaagttctcctgca-3'
T7549	40011-40012	CD	denotes	5
T7551	40012-40013	SYM	denotes	'
T7552	40013-40014	HYPH	denotes	-
T7550	40014-40037	NN	denotes	tctgaggatgttcacaggtttat
T7553	40037-40038	HYPH	denotes	-
T7554	40038-40039	CD	denotes	3
T7555	40039-40040	''	denotes	'
T7556	40041-40044	CC	denotes	and
T7557	40045-40046	CD	denotes	5
T7559	40046-40047	SYM	denotes	'
T7560	40047-40048	HYPH	denotes	-
T7558	40048-40070	NN	denotes	tcttctggaaagttctcctgca
T7561	40070-40071	HYPH	denotes	-
T7562	40071-40072	CD	denotes	3
T7563	40072-40073	SYM	denotes	'
T7564	40073-40241	sentence	denotes	Samples underwent 30 cycles of amplification with Perkin-Elmer Taq polymerase in a PTC Thermal Cycler (MJ Research, MA) (94° for 40 sec, 57° for 1 min, 72° for 2 min).
T7565	40074-40081	NNS	denotes	Samples
T7566	40082-40091	VBD	denotes	underwent
T7567	40092-40094	CD	denotes	30
T7568	40095-40101	NNS	denotes	cycles
T7569	40102-40104	IN	denotes	of
T7570	40105-40118	NN	denotes	amplification
T7571	40119-40123	IN	denotes	with
T7572	40124-40130	NNP	denotes	Perkin
T7574	40130-40131	HYPH	denotes	-
T7575	40131-40136	NNP	denotes	Elmer
T7573	40137-40140	NNP	denotes	Taq
T7576	40141-40151	NN	denotes	polymerase
T7577	40152-40154	IN	denotes	in
T7578	40155-40156	DT	denotes	a
T7580	40157-40160	NNP	denotes	PTC
T7581	40161-40168	NNP	denotes	Thermal
T7579	40169-40175	NNP	denotes	Cycler
T7582	40176-40177	-LRB-	denotes	(
T7584	40177-40179	NNP	denotes	MJ
T7583	40180-40188	NNP	denotes	Research
T7585	40188-40190	,	denotes	,
T7586	40190-40192	JJ	denotes	MA
T7587	40192-40193	-RRB-	denotes	)
T7588	40194-40195	-LRB-	denotes	(
T7590	40195-40197	CD	denotes	94
T7591	40197-40198	NNS	denotes	°
T7592	40199-40202	IN	denotes	for
T7593	40203-40205	CD	denotes	40
T7594	40206-40209	NN	denotes	sec
T7595	40209-40211	,	denotes	,
T7596	40211-40213	CD	denotes	57
T7597	40213-40214	NNS	denotes	°
T7598	40215-40218	IN	denotes	for
T7599	40219-40220	CD	denotes	1
T7600	40221-40224	NN	denotes	min
T7601	40224-40226	,	denotes	,
T7602	40226-40228	CD	denotes	72
T7589	40228-40229	NNS	denotes	°
T7603	40230-40233	IN	denotes	for
T7604	40234-40235	CD	denotes	2
T7605	40236-40239	NN	denotes	min
T7606	40239-40240	-RRB-	denotes	)
T7607	40240-40241	.	denotes	.
T7608	40241-40303	sentence	denotes	The PCR products we purified and sequenced as described [22].
T7609	40242-40245	DT	denotes	The
T7611	40246-40249	NN	denotes	PCR
T7610	40250-40258	NNS	denotes	products
T7613	40259-40261	PRP	denotes	we
T7612	40262-40270	VBN	denotes	purified
T7614	40271-40274	CC	denotes	and
T7615	40275-40284	VBN	denotes	sequenced
T7616	40285-40287	IN	denotes	as
T7617	40288-40297	VBN	denotes	described
T7618	40298-40299	-LRB-	denotes	[
T7619	40299-40301	CD	denotes	22
T7620	40301-40302	-RRB-	denotes	]
T7621	40302-40303	.	denotes	.
R1	T28	T29	amod	Intraocular,pressure
R10	T39	T40	compound	strain,survey
R100	T142	T137	cc	and,affect
R1000	T1306	T1305	quantmod	to,2.5
R1001	T1307	T1303	pobj	mmHg,by
R1002	T1308	T1293	punct	.,was
R1003	T1310	T1311	prep	Despite,changed
R1004	T1312	T1313	det	the,consistency
R1005	T1313	T1310	pobj	consistency,Despite
R1006	T1314	T1313	amod	general,consistency
R1007	T1315	T1313	prep	of,consistency
R1008	T1316	T1315	pobj	IOP,of
R1009	T1317	T1311	punct	", ",changed
R101	T143	T144	nsubj	aging,results
R1010	T1318	T1319	det	the,IOPs
R1011	T1319	T1311	nsubj	IOPs,changed
R1012	T1320	T1319	amod	average,IOPs
R1013	T1321	T1319	prep	of,IOPs
R1014	T1322	T1323	det	some,strains
R1015	T1323	T1321	pobj	strains,of
R1016	T1324	T1311	aux	have,changed
R1017	T1325	T1311	prep	in,changed
R1018	T1326	T1327	det	a,manner
R1019	T1327	T1325	pobj	manner,in
R102	T144	T137	conj	results,affect
R1020	T1328	T1327	amod	reproducible,manner
R1021	T1329	T1311	punct	.,changed
R1022	T1331	T1332	det	The,IOPs
R1023	T1332	T1333	nsubj	IOPs,were
R1024	T1334	T1332	prep	of,IOPs
R1025	T1335	T1336	compound	BALB,cJ
R1026	T1336	T1338	compound	cJ,mice
R1027	T1337	T1336	punct	/,cJ
R1028	T1338	T1334	pobj	mice,of
R1029	T1339	T1340	punct	(,end
R103	T145	T144	prep	in,results
R1030	T1340	T1332	parataxis	end,IOPs
R1031	T1341	T1340	amod	low,end
R1032	T1342	T1340	prep	of,end
R1033	T1343	T1342	pobj	spectrum,of
R1034	T1344	T1340	punct	),end
R1035	T1345	T1346	advmod	very,similar
R1036	T1346	T1333	acomp	similar,were
R1037	T1347	T1333	prep	for,were
R1038	T1348	T1349	quantmod	the,several
R1039	T1349	T1351	nummod	several,years
R104	T146	T147	det	an,decrease
R1040	T1350	T1349	amod	past,several
R1041	T1351	T1347	pobj	years,for
R1042	T1352	T1333	punct	", ",were
R1043	T1353	T1354	quantmod	around,11
R1044	T1354	T1355	nummod	11,mmHg
R1045	T1355	T1333	npadvmod	mmHg,were
R1046	T1356	T1333	punct	.,were
R1047	T1358	T1359	prep	Between,jump
R1048	T1360	T1361	advmod	early,1996
R1049	T1361	T1358	pobj	1996,Between
R105	T147	T145	pobj	decrease,in
R1050	T1362	T1361	cc	and,1996
R1051	T1363	T1361	conj	1997,1996
R1052	T1364	T1359	punct	", ",jump
R1053	T1365	T1359	advmod	however,jump
R1054	T1366	T1359	punct	", ",jump
R1055	T1367	T1368	det	the,IOP
R1056	T1368	T1359	nsubj	IOP,jump
R1057	T1369	T1368	prep	of,IOP
R1058	T1370	T1371	det	this,strain
R1059	T1371	T1369	pobj	strain,of
R106	T148	T147	compound	IOP,decrease
R1060	T1372	T1359	aux	did,jump
R1061	T1373	T1359	prep	from,jump
R1062	T1374	T1375	advmod	approximately,7.7
R1063	T1375	T1376	nummod	7.7,mmHg
R1064	T1376	T1373	pobj	mmHg,from
R1065	T1377	T1373	prep	to,from
R1066	T1378	T1379	advmod	approximately,11
R1067	T1379	T1380	nummod	11,mmHg
R1068	T1380	T1377	pobj	mmHg,to
R1069	T1381	T1382	punct	(,Figure
R107	T149	T144	prep	in,results
R1070	T1382	T1359	parataxis	Figure,jump
R1071	T1383	T1382	nummod	3,Figure
R1072	T1384	T1382	punct	),Figure
R1073	T1385	T1359	punct	.,jump
R1074	T1387	T1388	prep	During,changed
R1075	T1389	T1390	det	this,period
R1076	T1390	T1387	pobj	period,During
R1077	T1391	T1388	punct	", ",changed
R1078	T1392	T1393	det	the,room
R1079	T1393	T1388	nsubjpass	room,changed
R108	T150	T151	det	some,strains
R1080	T1394	T1395	prep	in,housed
R1081	T1395	T1393	relcl	housed,room
R1082	T1396	T1394	pobj	which,in
R1083	T1397	T1398	poss	our,animals
R1084	T1398	T1395	nsubjpass	animals,housed
R1085	T1399	T1395	auxpass	were,housed
R1086	T1400	T1393	cc	and,room
R1087	T1401	T1402	det	the,manufacturer
R1088	T1402	T1393	conj	manufacturer,room
R1089	T1403	T1402	prep	of,manufacturer
R109	T151	T149	pobj	strains,in
R1090	T1404	T1405	det	the,diet
R1091	T1405	T1403	pobj	diet,of
R1092	T1406	T1405	compound	mouse,diet
R1093	T1407	T1388	auxpass	were,changed
R1094	T1408	T1388	punct	.,changed
R1095	T1410	T1411	prep	Over,increased
R1096	T1412	T1413	det	the,period
R1097	T1413	T1410	pobj	period,Over
R1098	T1414	T1413	amod	same,period
R1099	T1415	T1411	punct	", ",increased
R11	T40	T31	conj	survey,update
R110	T152	T144	punct	.,results
R1100	T1416	T1417	det	the,IOP
R1101	T1417	T1411	nsubj	IOP,increased
R1102	T1418	T1417	prep	of,IOP
R1103	T1419	T1420	compound	A,J
R1104	T1420	T1418	pobj	J,of
R1105	T1421	T1420	punct	/,J
R1106	T1422	T1411	advmod	also,increased
R1107	T1423	T1411	advmod	dramatically,increased
R1108	T1424	T1411	punct	", ",increased
R1109	T1425	T1411	prep	from,increased
R111	T154	T155	amod	Most,strains
R1110	T1426	T1427	compound	9.4,0.5
R1111	T1427	T1429	nummod	0.5,mmHg
R1112	T1428	T1427	punct	±,0.5
R1113	T1429	T1425	pobj	mmHg,from
R1114	T1430	T1431	punct	(,11
R1115	T1431	T1429	parataxis	11,mmHg
R1116	T1432	T1431	nsubj	n,11
R1117	T1433	T1431	punct	=,11
R1118	T1434	T1431	punct	),11
R1119	T1435	T1429	prep	in,mmHg
R112	T155	T157	nsubj	strains,exhibit
R1120	T1436	T1435	pobj	1996,in
R1121	T1437	T1425	prep	to,from
R1122	T1438	T1439	compound	14.2,0.4
R1123	T1439	T1441	nummod	0.4,mmHg
R1124	T1440	T1439	punct	±,0.4
R1125	T1441	T1437	pobj	mmHg,to
R1126	T1442	T1443	punct	(,19
R1127	T1443	T1441	parataxis	19,mmHg
R1128	T1444	T1443	nsubj	n,19
R1129	T1445	T1443	punct	=,19
R113	T156	T155	amod	tested,strains
R1130	T1446	T1443	punct	),19
R1131	T1447	T1441	prep	in,mmHg
R1132	T1448	T1447	pobj	1997,in
R1133	T1449	T1411	punct	.,increased
R1134	T1451	T1452	det	The,IOP
R1135	T1452	T1454	nsubj	IOP,was
R1136	T1453	T1452	amod	increased,IOP
R1137	T1455	T1452	prep	in,IOP
R1138	T1456	T1457	compound	A,J
R1139	T1457	T1455	pobj	J,in
R114	T158	T159	det	a,rhythm
R1140	T1458	T1457	punct	/,J
R1141	T1459	T1454	advmod	also,was
R1142	T1460	T1454	acomp	reproducible,was
R1143	T1461	T1454	punct	", ",was
R1144	T1462	T1454	prep	with,was
R1145	T1463	T1464	det	the,IOP
R1146	T1464	T1466	nsubj	IOP,being
R1147	T1465	T1464	amod	average,IOP
R1148	T1466	T1462	pcomp	being,with
R1149	T1467	T1464	prep	of,IOP
R115	T159	T157	dobj	rhythm,exhibit
R1150	T1468	T1467	pobj	mice,of
R1151	T1469	T1468	acl	assessed,mice
R1152	T1470	T1469	prep	in,assessed
R1153	T1471	T1472	det	the,year
R1154	T1472	T1470	pobj	year,in
R1155	T1473	T1472	appos	2000,year
R1156	T1474	T1475	quantmod	14.5,0.4
R1157	T1475	T1477	nummod	0.4,mmHg
R1158	T1476	T1475	punct	±,0.4
R1159	T1477	T1466	attr	mmHg,being
R116	T160	T159	amod	diurnal,rhythm
R1160	T1478	T1479	punct	(,16
R1161	T1479	T1466	parataxis	16,being
R1162	T1480	T1479	nsubj	n,16
R1163	T1481	T1479	punct	=,16
R1164	T1482	T1479	punct	),16
R1165	T1483	T1454	punct	.,was
R1166	T1485	T1486	advmod	Importantly,change
R1167	T1487	T1486	punct	", ",change
R1168	T1488	T1489	det	the,IOPs
R1169	T1489	T1486	nsubj	IOPs,change
R117	T161	T157	prep	with,exhibit
R1170	T1490	T1489	prep	of,IOPs
R1171	T1491	T1492	compound	strains,B6
R1172	T1492	T1490	pobj	B6,of
R1173	T1493	T1492	cc	and,B6
R1174	T1494	T1495	compound	C3H,HeJ
R1175	T1495	T1492	conj	HeJ,B6
R1176	T1496	T1495	punct	/,HeJ
R1177	T1497	T1486	aux	did,change
R1178	T1498	T1486	neg	not,change
R1179	T1499	T1486	prep	during,change
R118	T162	T163	nsubj	IOP,being
R1180	T1500	T1501	det	this,time
R1181	T1501	T1499	pobj	time,during
R1182	T1502	T1503	punct	(,9
R1183	T1503	T1486	parataxis	9,change
R1184	T1504	T1505	dep	B6,10
R1185	T1505	T1503	dep	10,9
R1186	T1506	T1505	punct	", ",10
R1187	T1507	T1508	quantmod	12.3.,0.5
R1188	T1508	T1510	nummod	0.5,mmHg
R1189	T1509	T1508	punct	±,0.5
R119	T163	T161	pcomp	being,with
R1190	T1510	T1505	dep	mmHg,10
R1191	T1511	T1510	prep	in,mmHg
R1192	T1512	T1511	pobj	1996,in
R1193	T1513	T1510	cc	and,mmHg
R1194	T1514	T1515	quantmod	12.4,0.3
R1195	T1515	T1517	nummod	0.3,mmHg
R1196	T1516	T1515	punct	±,0.3
R1197	T1517	T1510	conj	mmHg,mmHg
R1198	T1518	T1517	prep	in,mmHg
R1199	T1519	T1518	pobj	1997,in
R12	T45	T46	nsubjpass	Little,known
R120	T164	T165	advmod	the,highest
R1200	T1520	T1505	punct	", ",10
R1201	T1521	T1505	nsubj	n,10
R1202	T1522	T1505	punct	=,10
R1203	T1523	T1505	cc	and,10
R1204	T1524	T1505	conj	14,10
R1205	T1525	T1503	punct	;,9
R1206	T1526	T1527	compound	C3H,HeJ
R1207	T1527	T1503	dep	HeJ,9
R1208	T1528	T1527	punct	/,HeJ
R1209	T1529	T1503	punct	", ",9
R121	T165	T163	acomp	highest,being
R1210	T1530	T1531	quantmod	13.7,0.8
R1211	T1531	T1533	nummod	0.8,mmHg
R1212	T1532	T1531	punct	±,0.8
R1213	T1533	T1503	dep	mmHg,9
R1214	T1534	T1533	prep	in,mmHg
R1215	T1535	T1534	pobj	1996,in
R1216	T1536	T1533	cc	and,mmHg
R1217	T1537	T1538	quantmod	13.6,0.2
R1218	T1538	T1540	nummod	0.2,mmHg
R1219	T1539	T1538	punct	±,0.2
R122	T166	T163	prep	during,being
R1220	T1540	T1533	conj	mmHg,mmHg
R1221	T1541	T1540	prep	in,mmHg
R1222	T1542	T1541	pobj	1997,in
R1223	T1543	T1503	punct	", ",9
R1224	T1544	T1503	nsubj	n,9
R1225	T1545	T1503	punct	=,9
R1226	T1546	T1503	cc	and,9
R1227	T1547	T1503	conj	19,9
R1228	T1548	T1503	punct	),9
R1229	T1549	T1486	punct	.,change
R123	T167	T168	det	the,period
R1230	T1569	T1568	prep	of,Effect
R1231	T1570	T1569	pobj	age,of
R1232	T1571	T1568	prep	on,Effect
R1233	T1572	T1571	pobj	IOP,on
R1234	T1574	T1575	nsubj	We,focused
R1235	T1576	T1575	prep	on,focused
R1236	T1577	T1578	det	the,strains
R1237	T1578	T1576	pobj	strains,on
R1238	T1579	T1580	advmod	commonly,used
R1239	T1580	T1578	amod	used,strains
R124	T168	T166	pobj	period,during
R1240	T1581	T1578	nmod	B6,strains
R1241	T1582	T1581	punct	", ",B6
R1242	T1583	T1584	compound	129P3,J
R1243	T1584	T1581	conj	J,B6
R1244	T1585	T1584	punct	/,J
R1245	T1586	T1584	cc	and,J
R1246	T1587	T1588	compound	C3H,HeJ
R1247	T1588	T1584	conj	HeJ,J
R1248	T1589	T1588	punct	/,HeJ
R1249	T1590	T1591	aux	to,determine
R125	T169	T168	amod	dark,period
R1250	T1591	T1575	advcl	determine,focused
R1251	T1592	T1593	det	the,effects
R1252	T1593	T1591	dobj	effects,determine
R1253	T1594	T1593	prep	of,effects
R1254	T1595	T1594	pobj	age,of
R1255	T1596	T1593	prep	on,effects
R1256	T1597	T1596	pobj	IOP,on
R1257	T1598	T1599	punct	(,Figure
R1258	T1599	T1575	parataxis	Figure,focused
R1259	T1600	T1599	nummod	4,Figure
R126	T170	T168	prep	of,period
R1260	T1601	T1599	punct	),Figure
R1261	T1602	T1575	punct	.,focused
R1262	T1604	T1605	prep	In,had
R1263	T1606	T1604	pobj	B6,In
R1264	T1607	T1605	punct	", ",had
R1265	T1608	T1605	nsubj	age,had
R1266	T1609	T1610	det	a,effect
R1267	T1610	T1605	dobj	effect,had
R1268	T1611	T1610	amod	significant,effect
R1269	T1612	T1610	prep	on,effect
R127	T171	T172	det	the,day
R1270	T1613	T1612	pobj	IOP,on
R1271	T1614	T1615	punct	(,0.001
R1272	T1615	T1605	parataxis	0.001,had
R1273	T1616	T1615	nsubj	P,0.001
R1274	T1617	T1615	punct	<,0.001
R1275	T1618	T1615	punct	),0.001
R1276	T1619	T1605	punct	.,had
R1277	T1621	T1622	nsubj	IOP,was
R1278	T1623	T1624	advmod	slightly,decreased
R1279	T1624	T1622	acomp	decreased,was
R128	T172	T170	pobj	day,of
R1280	T1625	T1622	prep	at,was
R1281	T1626	T1627	preconj	both,months
R1282	T1627	T1625	pobj	months,at
R1283	T1628	T1627	nummod	12,months
R1284	T1629	T1630	punct	(,mmHg
R1285	T1630	T1627	parataxis	mmHg,months
R1286	T1631	T1632	quantmod	12.2,0.2
R1287	T1632	T1630	nummod	0.2,mmHg
R1288	T1633	T1632	punct	±,0.2
R1289	T1634	T1630	punct	),mmHg
R129	T173	T157	punct	.,exhibit
R1290	T1635	T1627	cc	and,months
R1291	T1636	T1637	nummod	19,months
R1292	T1637	T1627	conj	months,months
R1293	T1638	T1639	punct	(,mmHg
R1294	T1639	T1637	parataxis	mmHg,months
R1295	T1640	T1641	quantmod	12.2,0.3
R1296	T1641	T1639	nummod	0.3,mmHg
R1297	T1642	T1641	punct	±,0.3
R1298	T1643	T1639	punct	),mmHg
R1299	T1644	T1622	prep	compared,was
R13	T47	T46	auxpass	is,known
R130	T175	T176	nsubj	Homozygosity,alter
R1300	T1645	T1644	prep	to,compared
R1301	T1646	T1647	nummod	3,months
R1302	T1647	T1645	pobj	months,to
R1303	T1648	T1649	punct	(,mmHg
R1304	T1649	T1647	parataxis	mmHg,months
R1305	T1650	T1651	quantmod	13.1,0.3
R1306	T1651	T1649	nummod	0.3,mmHg
R1307	T1652	T1651	punct	±,0.3
R1308	T1653	T1649	punct	),mmHg
R1309	T1654	T1647	cc	and,months
R131	T177	T175	prep	for,Homozygosity
R1310	T1655	T1656	nummod	7,months
R1311	T1656	T1647	conj	months,months
R1312	T1657	T1658	punct	(,mmHg
R1313	T1658	T1656	parataxis	mmHg,months
R1314	T1659	T1660	quantmod	13.3,0.3
R1315	T1660	T1658	nummod	0.3,mmHg
R1316	T1661	T1660	punct	±,0.3
R1317	T1662	T1658	punct	),mmHg
R1318	T1663	T1622	punct	.,was
R1319	T1665	T1666	mark	Although,was
R132	T178	T179	det	a,allele
R1320	T1666	T1669	advcl	was,decrease
R1321	T1667	T1668	det	the,decrease
R1322	T1668	T1666	nsubj	decrease,was
R1323	T1670	T1666	prep	of,was
R1324	T1671	T1672	det	a,level
R1325	T1672	T1670	pobj	level,of
R1326	T1673	T1672	amod	similar,level
R1327	T1674	T1672	prep	to,level
R1328	T1675	T1676	det	the,variation
R1329	T1676	T1674	pobj	variation,to
R133	T179	T177	pobj	allele,for
R1330	T1677	T1676	acl	observed,variation
R1331	T1678	T1677	prep	in,observed
R1332	T1679	T1680	npadvmod	3,old
R1333	T1680	T1682	amod	old,mice
R1334	T1681	T1679	quantmod	month,3
R1335	T1682	T1678	pobj	mice,in
R1336	T1683	T1684	punct	(,see
R1337	T1684	T1666	parataxis	see,was
R1338	T1685	T1684	dobj	Figure,see
R1339	T1686	T1685	nummod	3,Figure
R134	T180	T179	amod	null,allele
R1340	T1687	T1684	punct	),see
R1341	T1688	T1669	punct	", ",decrease
R1342	T1689	T1690	det	the,IOPs
R1343	T1690	T1669	nsubj	IOPs,decrease
R1344	T1691	T1690	prep	of,IOPs
R1345	T1692	T1693	nmod	control,mice
R1346	T1693	T1691	pobj	mice,of
R1347	T1694	T1693	amod	young,mice
R1348	T1695	T1696	punct	(,see
R1349	T1696	T1693	parataxis	see,mice
R135	T181	T179	prep	of,allele
R1350	T1697	T1696	dobj	Methods,see
R1351	T1698	T1696	punct	),see
R1352	T1699	T1693	acl	analyzed,mice
R1353	T1700	T1699	prep	at,analyzed
R1354	T1701	T1702	det	the,times
R1355	T1702	T1700	pobj	times,at
R1356	T1703	T1702	amod	same,times
R1357	T1704	T1702	prep	as,times
R1358	T1705	T1706	det	the,groups
R1359	T1706	T1704	pobj	groups,as
R136	T182	T183	det	the,gene
R1360	T1707	T1706	amod	various,groups
R1361	T1708	T1706	compound	B6,groups
R1362	T1709	T1706	compound	age,groups
R1363	T1710	T1669	aux	did,decrease
R1364	T1711	T1669	neg	not,decrease
R1365	T1712	T1669	punct	.,decrease
R1366	T1714	T1715	prep	For,had
R1367	T1716	T1714	pobj	example,For
R1368	T1717	T1715	punct	", ",had
R1369	T1718	T1719	compound	control,mice
R137	T183	T181	pobj	gene,of
R1370	T1719	T1715	nsubj	mice,had
R1371	T1720	T1719	acl	analyzed,mice
R1372	T1721	T1720	prep	at,analyzed
R1373	T1722	T1723	det	the,time
R1374	T1723	T1721	pobj	time,at
R1375	T1724	T1723	amod	same,time
R1376	T1725	T1723	prep	as,time
R1377	T1726	T1727	det	the,groups
R1378	T1727	T1725	pobj	groups,as
R1379	T1728	T1729	nummod	3,month
R138	T184	T183	amod	carbonic,gene
R1380	T1729	T1727	nmod	month,groups
R1381	T1730	T1729	punct	", ",month
R1382	T1731	T1732	nummod	12,month
R1383	T1732	T1729	conj	month,month
R1384	T1733	T1732	cc	and,month
R1385	T1734	T1735	nummod	18,month
R1386	T1735	T1732	conj	month,month
R1387	T1736	T1727	compound	B6,groups
R1388	T1737	T1727	compound	age,groups
R1389	T1738	T1715	dobj	IOPs,had
R139	T185	T183	nmod	anhydrase,gene
R1390	T1739	T1738	prep	of,IOPs
R1391	T1740	T1741	quantmod	13.0,0.2
R1392	T1741	T1743	nummod	0.2,mmHg
R1393	T1742	T1741	punct	±,0.2
R1394	T1743	T1739	pobj	mmHg,of
R1395	T1744	T1745	punct	(,14
R1396	T1745	T1743	parataxis	14,mmHg
R1397	T1746	T1745	nsubj	n,14
R1398	T1747	T1745	punct	=,14
R1399	T1748	T1745	punct	),14
R14	T48	T46	prep	about,known
R140	T186	T183	nummod	II,gene
R1400	T1749	T1743	punct	", ",mmHg
R1401	T1750	T1751	quantmod	13.3,0.2
R1402	T1751	T1753	nummod	0.2,mmHg
R1403	T1752	T1751	punct	±,0.2
R1404	T1753	T1743	appos	mmHg,mmHg
R1405	T1754	T1755	punct	(,14
R1406	T1755	T1753	parataxis	14,mmHg
R1407	T1756	T1755	nsubj	n,14
R1408	T1757	T1755	punct	=,14
R1409	T1758	T1755	punct	),14
R141	T187	T183	punct	(,gene
R1410	T1759	T1743	punct	", ",mmHg
R1411	T1760	T1761	quantmod	13.7,0.4
R1412	T1761	T1763	nummod	0.4,mmHg
R1413	T1762	T1761	punct	±,0.4
R1414	T1763	T1743	appos	mmHg,mmHg
R1415	T1764	T1765	punct	(,12
R1416	T1765	T1763	parataxis	12,mmHg
R1417	T1766	T1765	nsubj	n,12
R1418	T1767	T1765	punct	=,12
R1419	T1768	T1765	punct	),12
R142	T188	T183	appos	Car2n,gene
R1420	T1769	T1715	punct	", ",had
R1421	T1770	T1715	advmod	respectively,had
R1422	T1771	T1715	punct	.,had
R1423	T1773	T1774	nsubj	IOP,was
R1424	T1775	T1776	advmod	even,lower
R1425	T1776	T1774	acomp	lower,was
R1426	T1777	T1774	prep	in,was
R1427	T1778	T1779	det	the,mice
R1428	T1779	T1777	pobj	mice,in
R1429	T1780	T1781	nummod	24,month
R143	T189	T176	punct	),alter
R1430	T1781	T1779	compound	month,mice
R1431	T1782	T1779	compound	B6,mice
R1432	T1783	T1784	punct	(,mmHg
R1433	T1784	T1774	parataxis	mmHg,was
R1434	T1785	T1786	quantmod	10.8,0.4
R1435	T1786	T1784	nummod	0.4,mmHg
R1436	T1787	T1786	punct	±,0.4
R1437	T1788	T1784	punct	),mmHg
R1438	T1789	T1774	punct	", ",was
R1439	T1790	T1774	cc	and,was
R144	T190	T176	aux	does,alter
R1440	T1791	T1792	advmod	again,changed
R1441	T1792	T1774	conj	changed,was
R1442	T1793	T1794	det	the,IOP
R1443	T1794	T1792	nsubjpass	IOP,changed
R1444	T1795	T1794	amod	average,IOP
R1445	T1796	T1794	prep	of,IOP
R1446	T1797	T1798	amod	young,controls
R1447	T1798	T1796	pobj	controls,of
R1448	T1799	T1798	acl	measured,controls
R1449	T1800	T1799	prep	at,measured
R145	T191	T176	neg	not,alter
R1450	T1801	T1802	det	the,time
R1451	T1802	T1800	pobj	time,at
R1452	T1803	T1802	amod	same,time
R1453	T1804	T1792	auxpass	was,changed
R1454	T1805	T1792	neg	not,changed
R1455	T1806	T1807	punct	(,0.2
R1456	T1807	T1792	parataxis	0.2,changed
R1457	T1808	T1807	quantmod	13.5,0.2
R1458	T1809	T1807	punct	±,0.2
R1459	T1810	T1807	punct	", ",0.2
R146	T192	T176	dobj	IOP,alter
R1460	T1811	T1812	nsubj	n,12
R1461	T1812	T1807	ccomp	12,0.2
R1462	T1813	T1812	punct	=,12
R1463	T1814	T1807	punct	),0.2
R1464	T1815	T1792	punct	.,changed
R1465	T1817	T1818	prep	In,differ
R1466	T1819	T1820	compound	strain,J
R1467	T1820	T1817	pobj	J,In
R1468	T1821	T1820	compound	129P3,J
R1469	T1822	T1820	punct	/,J
R147	T193	T194	mark	while,results
R1470	T1823	T1818	punct	", ",differ
R1471	T1824	T1818	nsubj	IOP,differ
R1472	T1825	T1818	aux	did,differ
R1473	T1826	T1818	neg	not,differ
R1474	T1827	T1818	advmod	significantly,differ
R1475	T1828	T1818	prep	with,differ
R1476	T1829	T1828	pobj	age,with
R1477	T1830	T1829	prep	between,age
R1478	T1831	T1832	nummod	3,months
R1479	T1832	T1830	pobj	months,between
R148	T194	T176	advcl	results,alter
R1480	T1833	T1831	cc	and,3
R1481	T1834	T1831	conj	14,3
R1482	T1835	T1818	cc	but,differ
R1483	T1836	T1818	conj	was,differ
R1484	T1837	T1836	acomp	lower,was
R1485	T1838	T1836	prep	in,was
R1486	T1839	T1840	nummod	18,month
R1487	T1840	T1841	npadvmod	month,old
R1488	T1841	T1842	amod	old,mice
R1489	T1842	T1838	pobj	mice,in
R149	T195	T194	nsubj	homozygosity,results
R1490	T1843	T1844	punct	(,Figure
R1491	T1844	T1836	parataxis	Figure,was
R1492	T1845	T1846	nsubj	P,0.001
R1493	T1846	T1844	ccomp	0.001,Figure
R1494	T1847	T1846	punct	<,0.001
R1495	T1848	T1846	prep	compared,0.001
R1496	T1849	T1848	prep	to,compared
R1497	T1850	T1851	det	all,ages
R1498	T1851	T1849	pobj	ages,to
R1499	T1852	T1851	amod	younger,ages
R15	T49	T50	amod	genetic,factors
R150	T196	T195	prep	for,homozygosity
R1500	T1853	T1844	punct	", ",Figure
R1501	T1854	T1844	nummod	4,Figure
R1502	T1855	T1844	punct	),Figure
R1503	T1856	T1818	punct	.,differ
R1504	T1858	T1859	prep	Despite,were
R1505	T1860	T1861	det	a,dip
R1506	T1861	T1858	pobj	dip,Despite
R1507	T1862	T1863	nummod	1,mmHg
R1508	T1863	T1861	compound	mmHg,dip
R1509	T1864	T1861	prep	in,dip
R151	T197	T198	det	a,mutation
R1510	T1865	T1864	pobj	IOP,in
R1511	T1866	T1861	prep	at,dip
R1512	T1867	T1868	nummod	8,months
R1513	T1868	T1866	pobj	months,at
R1514	T1869	T1859	punct	", ",were
R1515	T1870	T1859	expl	there,were
R1516	T1871	T1872	det	no,differences
R1517	T1872	T1859	attr	differences,were
R1518	T1873	T1872	amod	significant,differences
R1519	T1874	T1872	compound	IOP,differences
R152	T198	T196	pobj	mutation,for
R1520	T1875	T1872	prep	between,differences
R1521	T1876	T1877	compound	C3H,HeJ
R1522	T1877	T1879	compound	HeJ,mice
R1523	T1878	T1877	punct	/,HeJ
R1524	T1879	T1875	pobj	mice,between
R1525	T1880	T1859	prep	at,were
R1526	T1881	T1882	det	each,age
R1527	T1882	T1880	pobj	age,at
R1528	T1883	T1882	acl	tested,age
R1529	T1884	T1885	punct	(,0.2
R153	T199	T198	prep	in,mutation
R1530	T1885	T1859	parataxis	0.2,were
R1531	T1886	T1885	nsubj	P,0.2
R1532	T1887	T1885	punct	=,0.2
R1533	T1888	T1885	prep	for,0.2
R1534	T1889	T1888	pobj	age,for
R1535	T1890	T1885	punct	),0.2
R1536	T1891	T1859	punct	.,were
R1537	T1893	T1894	mark	Although,assessed
R1538	T1894	T1903	advcl	assessed,identified
R1539	T1895	T1896	det	the,effect
R154	T200	T201	det	the,gene
R1540	T1896	T1894	nsubjpass	effect,assessed
R1541	T1897	T1896	prep	of,effect
R1542	T1898	T1897	pobj	age,of
R1543	T1899	T1894	aux	has,assessed
R1544	T1900	T1894	neg	not,assessed
R1545	T1901	T1894	auxpass	been,assessed
R1546	T1902	T1894	advmod	thoroughly,assessed
R1547	T1904	T1894	prep	in,assessed
R1548	T1905	T1906	amod	other,strains
R1549	T1906	T1904	pobj	strains,in
R155	T201	T199	pobj	gene,in
R1550	T1907	T1903	punct	", ",identified
R1551	T1908	T1909	det	no,differences
R1552	T1909	T1903	nsubjpass	differences,identified
R1553	T1910	T1909	amod	obvious,differences
R1554	T1911	T1912	npadvmod	age,related
R1555	T1912	T1909	amod	related,differences
R1556	T1913	T1912	punct	-,related
R1557	T1914	T1903	aux	have,identified
R1558	T1915	T1903	auxpass	been,identified
R1559	T1916	T1903	prep	in,identified
R156	T202	T201	compound	leptin,gene
R1560	T1917	T1918	amod	other,strains
R1561	T1918	T1916	pobj	strains,in
R1562	T1919	T1918	acl	analyzed,strains
R1563	T1920	T1919	prep	at,analyzed
R1564	T1921	T1922	amod	multiple,ages
R1565	T1922	T1920	pobj	ages,at
R1566	T1923	T1903	prep	except,identified
R1567	T1924	T1923	prep	for,except
R1568	T1925	T1926	det	the,strains
R1569	T1926	T1924	pobj	strains,for
R157	T203	T201	compound	receptor,gene
R1570	T1927	T1926	amod	glaucomatous,strains
R1571	T1928	T1929	nmod	DBA,2J
R1572	T1929	T1926	nmod	2J,strains
R1573	T1930	T1929	punct	/,2J
R1574	T1931	T1929	cc	and,2J
R1575	T1932	T1933	amod	AKXD,28/Ty
R1576	T1933	T1929	conj	28/Ty,2J
R1577	T1934	T1933	punct	-,28/Ty
R1578	T1935	T1936	punct	[,19
R1579	T1936	T1903	parataxis	19,identified
R158	T204	T201	punct	(,gene
R1580	T1937	T1936	nummod	14,19
R1581	T1938	T1936	punct	",",19
R1582	T1939	T1936	punct	],19
R1583	T1940	T1903	punct	.,identified
R1584	T1954	T1955	det	both,sexes
R1585	T1955	T2147	nsubjpass	sexes,analyzed
R1586	T1956	T2147	aux	have,analyzed
R1587	T1957	T2147	auxpass	been,analyzed
R1588	T1958	T2124	punct	", ",detected
R1589	T1959	T2124	cc	and,detected
R159	T205	T201	appos	Leprdb,gene
R1590	T1960	T1961	aux	have,proven
R1591	T1961	T2124	conj	proven,detected
R1592	T1962	T1961	oprd	inconsistent,proven
R1593	T1963	T1964	advmod	even,within
R1594	T1964	T1961	prep	within,proven
R1595	T1965	T1966	det	an,strain
R1596	T1966	T1964	pobj	strain,within
R1597	T1967	T1966	amod	individual,strain
R1598	T1968	T1966	acl	analyzed,strain
R1599	T1969	T1970	amod	multiple,times
R16	T50	T48	pobj	factors,about
R160	T206	T198	punct	),mutation
R1600	T1970	T1968	npadvmod	times,analyzed
R1601	T1971	T2124	punct	.,detected
R1602	T1973	T1974	compound	Strains,B6
R1603	T1974	T1975	nsubjpass	B6,evaluated
R1604	T1976	T1974	cc	and,B6
R1605	T1977	T1978	compound	129P3,J
R1606	T1978	T1974	conj	J,B6
R1607	T1979	T1978	punct	/,J
R1608	T1980	T1975	aux	have,evaluated
R1609	T1981	T1986	amod	multiple,ages
R161	T207	T208	dep	that,causes
R1610	T1982	T1975	auxpass	been,evaluated
R1611	T1983	T1975	advmod	extensively,evaluated
R1612	T1984	T2056	prep	of,IOP
R1613	T1985	T1975	prep	at,evaluated
R1614	T1986	T1985	pobj	ages,at
R1615	T1987	T1975	prep	between,evaluated
R1616	T1988	T1989	nummod	3,months
R1617	T1989	T1987	pobj	months,between
R1618	T1990	T1988	cc	and,3
R1619	T1991	T1988	conj	24,3
R162	T208	T198	relcl	causes,mutation
R1620	T1992	T1989	prep	of,months
R1621	T1993	T1992	pobj	age,of
R1622	T1994	T1975	punct	.,evaluated
R1623	T1996	T1997	compound	Sex,differences
R1624	T1997	T1998	nsubj	differences,were
R1625	T1999	T2000	advmod	always,absent
R1626	T2000	T1998	acomp	absent,were
R1627	T2001	T2000	prep	in,absent
R1628	T2002	T2003	compound	strain,J
R1629	T2003	T2001	pobj	J,in
R163	T209	T208	dobj	obesity,causes
R1630	T2004	T2003	compound	129P3,J
R1631	T2005	T2003	punct	/,J
R1632	T2006	T2000	cc	and,absent
R1633	T2007	T2008	advmod	typically,absent
R1634	T2008	T2000	conj	absent,absent
R1635	T2009	T2008	prep	in,absent
R1636	T2010	T2011	compound	strain,B6
R1637	T2011	T2009	pobj	B6,in
R1638	T2012	T1998	punct	.,were
R1639	T2014	T2015	prep	In,had
R164	T210	T209	cc	and,obesity
R1640	T2016	T2017	compound	strain,B6
R1641	T2017	T2014	pobj	B6,In
R1642	T2018	T2015	punct	", ",had
R1643	T2019	T2015	advmod	however,had
R1644	T2020	T2015	punct	", ",had
R1645	T2021	T2015	nsubj	males,had
R1646	T2022	T2015	advmod	infrequently,had
R1647	T2023	T2024	advmod	significantly,higher
R1648	T2024	T2025	amod	higher,IOP
R1649	T2025	T2015	dobj	IOP,had
R165	T211	T209	conj	diabetes,obesity
R1650	T2026	T2025	prep	than,IOP
R1651	T2027	T2026	pobj	females,than
R1652	T2028	T2015	punct	.,had
R1653	T2030	T2031	prep	For,had
R1654	T2032	T2030	pobj	example,For
R1655	T2033	T2031	punct	", ",had
R1656	T2034	T2031	prep	in,had
R1657	T2035	T2036	nummod	one,experiment
R1658	T2036	T2034	pobj	experiment,in
R1659	T2037	T2031	punct	", ",had
R166	T212	T194	prep	in,results
R1660	T2038	T2039	compound	B6,males
R1661	T2039	T2031	nsubj	males,had
R1662	T2040	T2041	det	an,IOP
R1663	T2041	T2031	dobj	IOP,had
R1664	T2042	T2041	amod	average,IOP
R1665	T2043	T2041	prep	of,IOP
R1666	T2044	T2045	quantmod	14.2,0.3
R1667	T2045	T2047	nummod	0.3,mmHg
R1668	T2046	T2045	punct	±,0.3
R1669	T2047	T2043	pobj	mmHg,of
R167	T213	T214	amod	increased,IOP
R1670	T2048	T2049	punct	(,12
R1671	T2049	T2047	parataxis	12,mmHg
R1672	T2050	T2049	nsubj	n,12
R1673	T2051	T2049	punct	=,12
R1674	T2052	T2049	punct	),12
R1675	T2053	T2054	mark	whereas,was
R1676	T2054	T2031	advcl	was,had
R1677	T2055	T2056	det	the,IOP
R1678	T2056	T2054	nsubj	IOP,was
R1679	T2057	T2056	amod	average,IOP
R168	T214	T212	pobj	IOP,in
R1680	T2058	T1984	pobj	females,of
R1681	T2059	T2060	quantmod	13.1,0.3
R1682	T2060	T2062	nummod	0.3,mmHg
R1683	T2061	T2060	punct	±,0.3
R1684	T2062	T2054	attr	mmHg,was
R1685	T2063	T2064	punct	(,0.01
R1686	T2064	T2054	parataxis	0.01,was
R1687	T2065	T2066	nsubj	n,12
R1688	T2066	T2064	ccomp	12,0.01
R1689	T2067	T2066	punct	=,12
R169	T215	T176	punct	.,alter
R1690	T2068	T2064	punct	", ",0.01
R1691	T2069	T2064	nsubj	P,0.01
R1692	T2070	T2064	punct	=,0.01
R1693	T2071	T2064	punct	),0.01
R1694	T2072	T2031	punct	.,had
R1695	T2074	T2075	mark	If,real
R1696	T2075	T2076	advcl	real,was
R1697	T2077	T2076	punct	", ",was
R1698	T2078	T2079	det	this,difference
R1699	T2079	T2076	nsubj	difference,was
R17	T51	T50	acl	affecting,factors
R170	T217	T218	compound	Albino,mice
R1700	T2080	T2079	amod	sporadic,difference
R1701	T2081	T2079	compound	sex,difference
R1702	T2082	T2076	neg	not,was
R1703	T2083	T2076	acomp	dependent,was
R1704	T2084	T2083	prep	on,dependent
R1705	T2085	T2084	pobj	age,on
R1706	T2086	T2076	punct	", ",was
R1707	T2087	T2088	advmod	sometimes,occurring
R1708	T2088	T2076	advcl	occurring,was
R1709	T2089	T2088	prep	in,occurring
R171	T218	T222	nsubj	mice,have
R1710	T2090	T2091	det	a,group
R1711	T2091	T2089	pobj	group,in
R1712	T2092	T2091	prep	of,group
R1713	T2093	T2094	compound	B6,mice
R1714	T2094	T2092	pobj	mice,of
R1715	T2095	T2088	prep	at,occurring
R1716	T2096	T2097	det	a,age
R1717	T2097	T2095	pobj	age,at
R1718	T2098	T2097	amod	particular,age
R1719	T2099	T2088	cc	and,occurring
R172	T219	T220	compound	C57BL,6J
R1720	T2100	T2101	advmod	sometimes,occurring
R1721	T2101	T2088	conj	occurring,occurring
R1722	T2102	T2101	neg	not,occurring
R1723	T2103	T2101	prep	in,occurring
R1724	T2104	T2105	det	a,group
R1725	T2105	T2103	pobj	group,in
R1726	T2106	T2105	amod	separate,group
R1727	T2107	T2105	prep	of,group
R1728	T2108	T2109	det	the,age
R1729	T2109	T2107	pobj	age,of
R173	T220	T218	compound	6J,mice
R1730	T2110	T2109	amod	same,age
R1731	T2111	T2076	punct	.,was
R1732	T2113	T2112	prep	of,Effect
R1733	T2114	T2113	pobj	sex,of
R1734	T2115	T2112	prep	on,Effect
R1735	T2116	T2115	pobj	IOP,on
R1736	T2118	T2119	mark	Although,assessed
R1737	T2119	T2124	advcl	assessed,detected
R1738	T2120	T2119	nsubj	we,assessed
R1739	T2121	T2119	aux	have,assessed
R174	T221	T220	punct	/,6J
R1740	T2122	T2119	neg	not,assessed
R1741	T2123	T2119	advmod	rigorously,assessed
R1742	T2125	T2126	det	the,effect
R1743	T2126	T2119	dobj	effect,assessed
R1744	T2127	T2126	prep	of,effect
R1745	T2128	T2127	pobj	sex,of
R1746	T2129	T2126	prep	on,effect
R1747	T2130	T2129	pobj	IOP,on
R1748	T2131	T2119	prep	in,assessed
R1749	T2132	T2133	amod	many,strains
R175	T223	T218	amod	homozygous,mice
R1750	T2133	T2131	pobj	strains,in
R1751	T2134	T2124	punct	", ",detected
R1752	T2135	T2136	npadvmod	sex,specific
R1753	T2136	T2137	amod	specific,differences
R1754	T2137	T2124	nsubjpass	differences,detected
R1755	T2138	T2124	aux	have,detected
R1756	T2139	T2124	neg	not,detected
R1757	T2140	T2124	auxpass	been,detected
R1758	T2141	T2124	prep	in,detected
R1759	T2142	T2143	det	the,majority
R176	T224	T223	prep	for,homozygous
R1760	T2143	T2141	pobj	majority,in
R1761	T2144	T2143	prep	of,majority
R1762	T2145	T2144	pobj	strains,of
R1763	T2146	T2147	prep	for,analyzed
R1764	T2147	T2143	relcl	analyzed,majority
R1765	T2148	T2146	pobj	which,for
R1766	T2161	T2162	compound	Anesthesia,protocol
R1767	T2162	T2163	nsubj	protocol,avoids
R1768	T2164	T2165	compound	IOP,alteration
R1769	T2165	T2163	dobj	alteration,avoids
R177	T225	T226	det	a,mutation
R1770	T2166	T2163	cc	and,avoids
R1771	T2167	T2163	conj	allows,avoids
R1772	T2168	T2167	dobj	detection,allows
R1773	T2169	T2168	prep	of,detection
R1774	T2170	T2171	amod	diurnal,differences
R1775	T2171	T2169	pobj	differences,of
R1776	T2173	T2174	det	All,IOPs
R1777	T2174	T2175	nsubjpass	IOPs,assessed
R1778	T2176	T2175	auxpass	were,assessed
R1779	T2177	T2175	advcl	using,assessed
R178	T226	T224	pobj	mutation,for
R1780	T2178	T2179	det	an,regime
R1781	T2179	T2177	dobj	regime,using
R1782	T2180	T2179	amod	anesthetic,regime
R1783	T2181	T2179	prep	of,regime
R1784	T2182	T2183	nummod	99,mg
R1785	T2183	T2184	nmod	mg,ketamine
R1786	T2184	T2181	pobj	ketamine,of
R1787	T2185	T2186	punct	/,kg
R1788	T2186	T2183	prep	kg,mg
R1789	T2187	T2184	cc	and,ketamine
R179	T227	T226	compound	tyrosinase,mutation
R1790	T2188	T2189	nummod	9,mg
R1791	T2189	T2190	nmod	mg,xylazine
R1792	T2190	T2184	conj	xylazine,ketamine
R1793	T2191	T2192	punct	/,kg
R1794	T2192	T2189	prep	kg,mg
R1795	T2193	T2194	punct	(,defined
R1796	T2194	T2190	parataxis	defined,xylazine
R1797	T2195	T2194	prep	as,defined
R1798	T2196	T2195	pobj	1X,as
R1799	T2197	T2194	punct	),defined
R18	T52	T53	amod	intraocular,pressure
R180	T228	T226	punct	(,mutation
R1800	T2198	T2175	punct	.,assessed
R1801	T2200	T2201	amod	Initial,experiments
R1802	T2201	T2202	nsubj	experiments,suggested
R1803	T2203	T2204	mark	that,had
R1804	T2204	T2202	ccomp	had,suggested
R1805	T2205	T2206	det	an,dose
R1806	T2206	T2204	nsubj	dose,had
R1807	T2207	T2208	advmod	almost,identical
R1808	T2208	T2206	amod	identical,dose
R1809	T2209	T2206	punct	(,dose
R181	T229	T230	compound	Tyrc,2J
R1810	T2210	T2211	nummod	100,mg
R1811	T2211	T2212	nmod	mg,ketamine
R1812	T2212	T2206	appos	ketamine,dose
R1813	T2213	T2214	punct	/,kg
R1814	T2214	T2211	prep	kg,mg
R1815	T2215	T2212	cc	and,ketamine
R1816	T2216	T2217	nummod	9,mg
R1817	T2217	T2218	nmod	mg,xylazine
R1818	T2218	T2212	conj	xylazine,ketamine
R1819	T2219	T2220	punct	/,kg
R182	T230	T226	appos	2J,mutation
R1820	T2220	T2217	prep	kg,mg
R1821	T2221	T2206	punct	),dose
R1822	T2222	T2206	prep	of,dose
R1823	T2223	T2222	pobj	anesthesia,of
R1824	T2224	T2225	det	no,effect
R1825	T2225	T2204	dobj	effect,had
R1826	T2226	T2225	prep	on,effect
R1827	T2227	T2226	pobj	IOP,on
R1828	T2228	T2204	prep	during,had
R1829	T2229	T2230	det	the,period
R183	T231	T230	punct	-,2J
R1830	T2230	T2228	pobj	period,during
R1831	T2231	T2230	amod	experimental,period
R1832	T2232	T2204	prep	with,had
R1833	T2233	T2234	nsubjpass	IOP,measured
R1834	T2234	T2232	pcomp	measured,with
R1835	T2235	T2234	auxpass	being,measured
R1836	T2236	T2237	advmod	as,soon
R1837	T2237	T2234	advmod	soon,measured
R1838	T2238	T2237	prep	as,soon
R1839	T2239	T2238	pcomp	possible,as
R184	T232	T222	punct	),have
R1840	T2240	T2241	mark	after,was
R1841	T2241	T2234	advcl	was,measured
R1842	T2242	T2243	det	the,mouse
R1843	T2243	T2241	nsubj	mouse,was
R1844	T2244	T2241	acomp	unconscious,was
R1845	T2245	T2234	punct	", ",measured
R1846	T2246	T2247	advmod	typically,minutes
R1847	T2247	T2234	npadvmod	minutes,measured
R1848	T2248	T2202	punct	.,suggested
R1849	T2249	T2250	punct	[,13
R185	T233	T234	amod	higher,IOPs
R1850	T2250	T2202	parataxis	13,suggested
R1851	T2251	T2250	punct	],13
R1852	T2252	T2202	punct	.,suggested
R1853	T2254	T2255	aux	To,assess
R1854	T2255	T2257	advcl	assess,measured
R1855	T2256	T2255	advmod	further,assess
R1856	T2258	T2259	det	the,effects
R1857	T2259	T2255	dobj	effects,assess
R1858	T2260	T2259	prep	of,effects
R1859	T2261	T2260	pobj	anesthesia,of
R186	T234	T222	dobj	IOPs,have
R1860	T2262	T2257	punct	", ",measured
R1861	T2263	T2257	nsubj	we,measured
R1862	T2264	T2257	dobj	IOP,measured
R1863	T2265	T2257	prep	in,measured
R1864	T2266	T2265	pobj	groups,in
R1865	T2267	T2266	prep	of,groups
R1866	T2268	T2269	advmod	genetically,identical
R1867	T2269	T2270	amod	identical,mice
R1868	T2270	T2267	pobj	mice,of
R1869	T2271	T2270	compound	B6,mice
R187	T235	T234	prep	than,IOPs
R1870	T2272	T2266	acl	subjected,groups
R1871	T2273	T2272	prep	to,subjected
R1872	T2274	T2275	amod	different,doses
R1873	T2275	T2273	pobj	doses,to
R1874	T2276	T2275	punct	(,doses
R1875	T2277	T2275	appos	1X,doses
R1876	T2278	T2277	punct	", ",1X
R1877	T2279	T2277	conj	1.5X,1X
R1878	T2280	T2279	cc	and,1.5X
R1879	T2281	T2279	conj	2X,1.5X
R188	T236	T237	poss	their,counterparts
R1880	T2282	T2272	punct	),subjected
R1881	T2283	T2272	prep	at,subjected
R1882	T2284	T2285	nummod	5,minutes
R1883	T2285	T2283	pobj	minutes,at
R1884	T2286	T2284	cc	and,5
R1885	T2287	T2284	conj	25,5
R1886	T2288	T2285	prep	after,minutes
R1887	T2289	T2288	pobj	administration,after
R1888	T2290	T2291	punct	(,Figure
R1889	T2291	T2257	parataxis	Figure,measured
R189	T237	T235	pobj	counterparts,than
R1890	T2292	T2291	nummod	5,Figure
R1891	T2293	T2291	punct	),Figure
R1892	T2294	T2257	punct	.,measured
R1893	T2296	T2297	prep	For,decreased
R1894	T2298	T2299	det	all,doses
R1895	T2299	T2296	pobj	doses,For
R1896	T2300	T2297	punct	", ",decreased
R1897	T2301	T2297	nsubj	IOP,decreased
R1898	T2302	T2297	prep	by,decreased
R1899	T2303	T2304	nummod	25,minutes
R19	T53	T51	dobj	pressure,affecting
R190	T238	T237	amod	pigmented,counterparts
R1900	T2304	T2302	pobj	minutes,by
R1901	T2305	T2306	punct	(,0.005
R1902	T2306	T2297	parataxis	0.005,decreased
R1903	T2307	T2306	nsubj	P,0.005
R1904	T2308	T2306	punct	=,0.005
R1905	T2309	T2306	prep	for,0.005
R1906	T2310	T2309	pobj	time,for
R1907	T2311	T2306	punct	),0.005
R1908	T2312	T2297	punct	.,decreased
R1909	T2314	T2315	advmod	The,greater
R191	T239	T222	punct	.,have
R1910	T2315	T2316	advcl	greater,decrease
R1911	T2317	T2318	det	the,dose
R1912	T2318	T2315	advcl	dose,greater
R1913	T2319	T2320	advmod	the,greater
R1914	T2320	T2316	acomp	greater,decrease
R1915	T2321	T2316	det	the,decrease
R1916	T2322	T2316	prep	in,decrease
R1917	T2323	T2322	pobj	IOP,in
R1918	T2324	T2316	punct	.,decrease
R1919	T2326	T2327	prep	At,was
R192	T243	T244	advmod	Genetically,distinct
R1920	T2328	T2329	det	the,measurement
R1921	T2329	T2326	pobj	measurement,At
R1922	T2330	T2331	nummod	5,minute
R1923	T2331	T2329	nmod	minute,measurement
R1924	T2332	T2327	punct	", ",was
R1925	T2333	T2327	advmod	however,was
R1926	T2334	T2327	punct	", ",was
R1927	T2335	T2327	nsubj	IOP,was
R1928	T2336	T2337	advmod	the,same
R1929	T2337	T2327	acomp	same,was
R193	T244	T245	amod	distinct,strains
R1930	T2338	T2327	advcl	using,was
R1931	T2339	T2340	det	all,doses
R1932	T2340	T2338	dobj	doses,using
R1933	T2341	T2327	advcl	suggesting,was
R1934	T2342	T2343	mark	that,occurred
R1935	T2343	T2341	ccomp	occurred,suggesting
R1936	T2344	T2345	det	the,effect
R1937	T2345	T2343	nsubj	effect,occurred
R1938	T2346	T2345	amod	anesthetic,effect
R1939	T2347	T2345	prep	on,effect
R194	T245	T247	nsubj	strains,have
R1940	T2348	T2347	pobj	IOP,on
R1941	T2349	T2343	aux	had,occurred
R1942	T2350	T2343	neg	not,occurred
R1943	T2351	T2343	advmod	yet,occurred
R1944	T2352	T2327	punct	.,was
R1945	T2354	T2355	aux	To,identify
R1946	T2355	T2356	advcl	identify,anesthetized
R1947	T2357	T2358	det	any,window
R1948	T2358	T2355	dobj	window,identify
R1949	T2359	T2358	amod	early,window
R195	T246	T245	compound	mouse,strains
R1950	T2360	T2361	advmod	when,be
R1951	T2361	T2355	advcl	be,identify
R1952	T2362	T2361	nsubj	it,be
R1953	T2363	T2361	aux	may,be
R1954	T2364	T2361	acomp	possible,be
R1955	T2365	T2366	aux	to,assess
R1956	T2366	T2361	xcomp	assess,be
R1957	T2367	T2366	dobj	IOP,assess
R1958	T2368	T2366	prep	without,assess
R1959	T2369	T2370	det	an,effect
R196	T248	T245	acl	housed,strains
R1960	T2370	T2368	pobj	effect,without
R1961	T2371	T2370	amod	obvious,effect
R1962	T2372	T2370	amod	anesthetic,effect
R1963	T2373	T2356	punct	", ",anesthetized
R1964	T2374	T2375	nummod	195,mice
R1965	T2375	T2356	nsubjpass	mice,anesthetized
R1966	T2376	T2375	prep	of,mice
R1967	T2377	T2378	compound	strain,B6
R1968	T2378	T2376	pobj	B6,of
R1969	T2379	T2356	auxpass	were,anesthetized
R197	T249	T248	prep	in,housed
R1970	T2380	T2356	prep	with,anesthetized
R1971	T2381	T2382	det	the,dose
R1972	T2382	T2380	pobj	dose,with
R1973	T2383	T2382	compound	1X,dose
R1974	T2384	T2356	cc	and,anesthetized
R1975	T2385	T2386	nsubjpass	IOP,measured
R1976	T2386	T2356	conj	measured,anesthetized
R1977	T2387	T2386	auxpass	was,measured
R1978	T2388	T2386	prep	at,measured
R1979	T2389	T2390	nummod	1,minute
R198	T250	T251	det	the,environment
R1980	T2390	T2391	compound	minute,points
R1981	T2391	T2388	pobj	points,at
R1982	T2392	T2391	compound	time,points
R1983	T2393	T2394	quantmod	between,4
R1984	T2394	T2395	nummod	4,minutes
R1985	T2395	T2391	appos	minutes,points
R1986	T2396	T2394	cc	and,4
R1987	T2397	T2394	conj	12,4
R1988	T2398	T2395	prep	after,minutes
R1989	T2399	T2398	pobj	administration,after
R199	T251	T249	pobj	environment,in
R1990	T2400	T2401	punct	(,Figure
R1991	T2401	T2356	parataxis	Figure,anesthetized
R1992	T2402	T2401	nummod	5,Figure
R1993	T2403	T2401	punct	),Figure
R1994	T2404	T2356	punct	.,anesthetized
R1995	T2406	T2407	det	The,IOP
R1996	T2407	T2409	nsubj	IOP,differ
R1997	T2408	T2407	amod	mean,IOP
R1998	T2410	T2407	prep	of,IOP
R1999	T2411	T2410	pobj	groups,of
R2	T29	T31	dep	pressure,update
R20	T54	T55	punct	(,IOP
R200	T252	T251	amod	same,environment
R2000	T2412	T2411	acl	analyzed,groups
R2001	T2413	T2412	prep	at,analyzed
R2002	T2414	T2415	det	each,point
R2003	T2415	T2413	pobj	point,at
R2004	T2416	T2415	compound	time,point
R2005	T2417	T2409	aux	did,differ
R2006	T2418	T2409	neg	not,differ
R2007	T2419	T2420	punct	(,0.9
R2008	T2420	T2409	parataxis	0.9,differ
R2009	T2421	T2420	nsubj	P,0.9
R201	T253	T254	det	a,range
R2010	T2422	T2420	punct	=,0.9
R2011	T2423	T2420	punct	),0.9
R2012	T2424	T2409	advcl	indicating,differ
R2013	T2425	T2426	mark	that,occurs
R2014	T2426	T2424	ccomp	occurs,indicating
R2015	T2427	T2428	det	the,effect
R2016	T2428	T2426	nsubj	effect,occurs
R2017	T2429	T2430	npadvmod	IOP,depressing
R2018	T2430	T2428	amod	depressing,effect
R2019	T2431	T2428	prep	of,effect
R202	T254	T247	dobj	range,have
R2020	T2432	T2431	pobj	anesthesia,of
R2021	T2433	T2426	advmod	later,occurs
R2022	T2434	T2433	prep	than,later
R2023	T2435	T2436	nummod	12,minutes
R2024	T2436	T2437	npadvmod	minutes,after
R2025	T2437	T2434	prep	after,than
R2026	T2438	T2437	pobj	administration,after
R2027	T2439	T2409	punct	.,differ
R2028	T2441	T2442	amod	Similar,results
R2029	T2442	T2443	nsubjpass	results,obtained
R203	T255	T254	amod	broad,range
R2030	T2444	T2443	auxpass	were,obtained
R2031	T2445	T2443	advcl	using,obtained
R2032	T2446	T2447	nummod	161,J
R2033	T2447	T2451	nmod	J,mice
R2034	T2448	T2447	nmod	strain,J
R2035	T2449	T2447	nmod	129P3,J
R2036	T2450	T2447	punct	/,J
R2037	T2451	T2445	dobj	mice,using
R2038	T2452	T2447	cc	and,J
R2039	T2453	T2454	nummod	145,2J
R204	T256	T254	prep	of,range
R2040	T2454	T2447	conj	2J,J
R2041	T2455	T2454	compound	strain,2J
R2042	T2456	T2454	compound	DBA,2J
R2043	T2457	T2454	punct	/,2J
R2044	T2458	T2451	prep	with,mice
R2045	T2459	T2460	det	the,dose
R2046	T2460	T2458	pobj	dose,with
R2047	T2461	T2460	compound	1X,dose
R2048	T2462	T2463	punct	(,0.2
R2049	T2463	T2445	parataxis	0.2,using
R205	T257	T256	pobj	IOPs,of
R2050	T2464	T2465	compound	129P3,J
R2051	T2465	T2467	dep	J,0.1
R2052	T2466	T2465	punct	/,J
R2053	T2467	T2463	dep	0.1,0.2
R2054	T2468	T2467	punct	", ",0.1
R2055	T2469	T2467	nsubj	P,0.1
R2056	T2470	T2467	punct	=,0.1
R2057	T2471	T2463	punct	;,0.2
R2058	T2472	T2473	compound	DBA,2J
R2059	T2473	T2463	dep	2J,0.2
R206	T258	T247	punct	.,have
R2060	T2474	T2473	punct	/,2J
R2061	T2475	T2463	punct	", ",0.2
R2062	T2476	T2463	nsubj	P,0.2
R2063	T2477	T2463	punct	=,0.2
R2064	T2478	T2463	punct	),0.2
R2065	T2479	T2443	punct	.,obtained
R2066	T2481	T2482	prep	In,identified
R2067	T2483	T2481	pobj	support,In
R2068	T2484	T2483	prep	of,support
R2069	T2485	T2486	det	a,effect
R207	T260	T261	det	These,differences
R2070	T2486	T2484	pobj	effect,of
R2071	T2487	T2486	amod	later,effect
R2072	T2488	T2486	prep	of,effect
R2073	T2489	T2488	pobj	anesthesia,of
R2074	T2490	T2482	punct	(,identified
R2075	T2491	T2492	mark	since,reported
R2076	T2492	T2482	advcl	reported,identified
R2077	T2493	T2494	amod	general,anesthesia
R2078	T2494	T2492	nsubjpass	anesthesia,reported
R2079	T2495	T2492	auxpass	is,reported
R208	T261	T263	nsubj	differences,are
R2080	T2496	T2497	aux	to,mask
R2081	T2497	T2492	xcomp	mask,reported
R2082	T2498	T2499	amod	diurnal,variation
R2083	T2499	T2497	dobj	variation,mask
R2084	T2500	T2497	prep	in,mask
R2085	T2501	T2500	pobj	IOP,in
R2086	T2502	T2503	punct	[,21
R2087	T2503	T2482	parataxis	21,identified
R2088	T2504	T2503	punct	],21
R2089	T2505	T2482	punct	),identified
R209	T262	T261	compound	IOP,differences
R2090	T2506	T2482	punct	", ",identified
R2091	T2507	T2482	nsubj	we,identified
R2092	T2508	T2509	amod	increased,IOP
R2093	T2509	T2482	dobj	IOP,identified
R2094	T2510	T2509	prep	during,IOP
R2095	T2511	T2512	det	the,dark
R2096	T2512	T2510	pobj	dark,during
R2097	T2513	T2512	prep	compared,dark
R2098	T2514	T2513	prep	to,compared
R2099	T2515	T2516	det	the,light
R21	T55	T53	appos	IOP,pressure
R210	T264	T263	advmod	likely,are
R2100	T2516	T2514	pobj	light,to
R2101	T2517	T2512	appos	period,dark
R2102	T2518	T2517	prep	of,period
R2103	T2519	T2520	det	the,day
R2104	T2520	T2518	pobj	day,of
R2105	T2521	T2509	prep	in,IOP
R2106	T2522	T2523	amod	several,strains
R2107	T2523	T2521	pobj	strains,in
R2108	T2524	T2523	amod	tested,strains
R2109	T2525	T2526	punct	(,Figure
R211	T265	T263	prep	due,are
R2110	T2526	T2482	parataxis	Figure,identified
R2111	T2527	T2526	nummod	6,Figure
R2112	T2528	T2526	punct	),Figure
R2113	T2529	T2482	punct	.,identified
R2114	T2531	T2532	prep	In,made
R2115	T2533	T2534	det	these,experiments
R2116	T2534	T2531	pobj	experiments,In
R2117	T2535	T2532	punct	", ",made
R2118	T2536	T2537	compound	IOP,measurements
R2119	T2537	T2532	nsubjpass	measurements,made
R212	T266	T265	pcomp	to,due
R2120	T2538	T2532	auxpass	were,made
R2121	T2539	T2540	quantmod	between,5
R2122	T2540	T2541	nummod	5,minutes
R2123	T2541	T2544	npadvmod	minutes,after
R2124	T2542	T2540	cc	and,5
R2125	T2543	T2540	conj	12,5
R2126	T2544	T2532	prep	after,made
R2127	T2545	T2544	pobj	administration,after
R2128	T2546	T2545	prep	of,administration
R2129	T2547	T2546	pobj	anesthesia,of
R213	T267	T268	amod	interstrain,differences
R2130	T2548	T2532	punct	.,made
R2131	T2575	T2576	compound	Blood,pressure
R2132	T2576	T2577	nsubj	pressure,correlate
R2133	T2578	T2577	aux	does,correlate
R2134	T2579	T2577	neg	not,correlate
R2135	T2580	T2577	prep	with,correlate
R2136	T2581	T2580	pobj	IOP,with
R2137	T2583	T2584	det	An,study
R2138	T2584	T2586	nsubj	study,detect
R2139	T2585	T2584	amod	initial,study
R214	T268	T265	pobj	differences,due
R2140	T2587	T2584	prep	of,study
R2141	T2588	T2589	det	the,relationship
R2142	T2589	T2587	pobj	relationship,of
R2143	T2590	T2589	prep	between,relationship
R2144	T2591	T2592	compound	blood,pressure
R2145	T2592	T2590	pobj	pressure,between
R2146	T2593	T2592	cc	and,pressure
R2147	T2594	T2592	conj	IOP,pressure
R2148	T2595	T2589	prep	in,relationship
R2149	T2596	T2595	pobj	mice,in
R215	T269	T268	amod	genetic,differences
R2150	T2597	T2586	aux	did,detect
R2151	T2598	T2586	neg	not,detect
R2152	T2599	T2600	det	a,correlation
R2153	T2600	T2586	dobj	correlation,detect
R2154	T2601	T2600	amod	good,correlation
R2155	T2602	T2603	punct	(,Figure
R2156	T2603	T2586	parataxis	Figure,detect
R2157	T2604	T2605	nsubj	R2,0.1
R2158	T2605	T2603	ccomp	0.1,Figure
R2159	T2606	T2605	punct	=,0.1
R216	T270	T271	dep	that,create
R2160	T2607	T2603	punct	", ",Figure
R2161	T2608	T2603	nummod	7,Figure
R2162	T2609	T2603	punct	),Figure
R2163	T2610	T2586	punct	.,detect
R2164	T2627	T2628	compound	Myoc,alleles
R2165	T2628	T2629	nsubj	alleles,associate
R2166	T2630	T2629	aux	do,associate
R2167	T2631	T2629	neg	not,associate
R2168	T2632	T2629	prep	with,associate
R2169	T2633	T2634	det	the,magnitude
R217	T271	T268	relcl	create,differences
R2170	T2634	T2632	pobj	magnitude,with
R2171	T2635	T2634	prep	of,magnitude
R2172	T2636	T2635	pobj	IOP,of
R2173	T2638	T2639	nsubj	Mutations,cause
R2174	T2640	T2638	prep	in,Mutations
R2175	T2641	T2642	det	the,gene
R2176	T2642	T2640	pobj	gene,in
R2177	T2643	T2642	compound	myocilin,gene
R2178	T2644	T2642	punct	(,gene
R2179	T2645	T2642	appos	MYOC,gene
R218	T272	T273	det	a,resource
R2180	T2646	T2639	punct	),cause
R2181	T2647	T2648	amod	human,glaucoma
R2182	T2648	T2639	dobj	glaucoma,cause
R2183	T2649	T2639	punct	.,cause
R2184	T2651	T2652	aux	To,determine
R2185	T2652	T2653	advcl	determine,analyzed
R2186	T2654	T2655	mark	if,associated
R2187	T2655	T2652	ccomp	associated,determine
R2188	T2656	T2657	amod	allelic,variation
R2189	T2657	T2655	nsubj	variation,associated
R219	T273	T271	dobj	resource,create
R2190	T2658	T2657	prep	in,variation
R2191	T2659	T2660	det	the,gene
R2192	T2660	T2658	pobj	gene,in
R2193	T2661	T2660	compound	mouse,gene
R2194	T2662	T2660	compound	Myoc,gene
R2195	T2663	T2655	prep	with,associated
R2196	T2664	T2663	pobj	IOP,with
R2197	T2665	T2655	prep	in,associated
R2198	T2666	T2667	compound	mouse,strains
R2199	T2667	T2665	pobj	strains,in
R22	T56	T53	punct	),pressure
R220	T274	T273	amod	powerful,resource
R2200	T2668	T2653	punct	", ",analyzed
R2201	T2669	T2653	nsubj	we,analyzed
R2202	T2670	T2671	det	the,gene
R2203	T2671	T2653	dobj	gene,analyzed
R2204	T2672	T2653	prep	in,analyzed
R2205	T2673	T2674	det	an,assortment
R2206	T2674	T2672	pobj	assortment,in
R2207	T2675	T2674	prep	of,assortment
R2208	T2676	T2675	pobj	strains,of
R2209	T2677	T2676	prep	with,strains
R221	T275	T271	prep	for,create
R2210	T2678	T2679	amod	different,IOPs
R2211	T2679	T2677	pobj	IOPs,with
R2212	T2680	T2653	punct	.,analyzed
R2213	T2682	T2683	nummod	Two,alleles
R2214	T2683	T2684	nsubjpass	alleles,identified
R2215	T2685	T2684	auxpass	were,identified
R2216	T2686	T2684	punct	.,identified
R2217	T2688	T2689	nsubj	One,had
R2218	T2690	T2688	prep	of,One
R2219	T2691	T2692	det	these,alleles
R222	T276	T275	pcomp	studying,for
R2220	T2692	T2690	pobj	alleles,of
R2221	T2693	T2694	det	a,insertion
R2222	T2694	T2689	dobj	insertion,had
R2223	T2695	T2696	nummod	12,nucleotide
R2224	T2696	T2694	compound	nucleotide,insertion
R2225	T2697	T2694	prep	in,insertion
R2226	T2698	T2699	det	the,region
R2227	T2699	T2697	pobj	region,in
R2228	T2700	T2699	compound	promoter,region
R2229	T2701	T2694	punct	(,insertion
R223	T277	T278	det	the,regulation
R2230	T2702	T2694	appos	ccagagcagggt,insertion
R2231	T2703	T2702	punct	", ",ccagagcagggt
R2232	T2704	T2702	prep	between,ccagagcagggt
R2233	T2705	T2706	nmod	positions,340
R2234	T2706	T2704	pobj	340,between
R2235	T2707	T2706	punct	-,340
R2236	T2708	T2706	cc	and,340
R2237	T2709	T2710	punct	-,341
R2238	T2710	T2706	conj	341,340
R2239	T2711	T2689	punct	),had
R224	T278	T276	dobj	regulation,studying
R2240	T2712	T2689	prep	compared,had
R2241	T2713	T2712	prep	to,compared
R2242	T2714	T2715	det	the,sequence
R2243	T2715	T2713	pobj	sequence,to
R2244	T2716	T2717	advmod	previously,published
R2245	T2717	T2715	amod	published,sequence
R2246	T2718	T2689	cc	and,had
R2247	T2719	T2720	auxpass	is,called
R2248	T2720	T2689	conj	called,had
R2249	T2721	T2722	det	the,allele
R225	T279	T278	prep	of,regulation
R2250	T2722	T2720	oprd	allele,called
R2251	T2723	T2722	compound	insertion,allele
R2252	T2724	T2689	punct	.,had
R2253	T2726	T2727	det	The,allele
R2254	T2727	T2729	nsubj	allele,was
R2255	T2728	T2727	amod	other,allele
R2256	T2730	T2729	acomp	identical,was
R2257	T2731	T2730	prep	to,identical
R2258	T2732	T2733	det	the,sequence
R2259	T2733	T2731	pobj	sequence,to
R226	T280	T279	pobj	IOP,of
R2260	T2734	T2733	amod	published,sequence
R2261	T2735	T2736	punct	[,22
R2262	T2736	T2729	parataxis	22,was
R2263	T2737	T2736	punct	],22
R2264	T2738	T2729	punct	.,was
R2265	T2740	T2741	det	The,allele
R2266	T2741	T2743	nsubj	allele,had
R2267	T2742	T2741	compound	insertion,allele
R2268	T2744	T2743	advmod	also,had
R2269	T2745	T2746	det	a,substitution
R227	T281	T263	punct	.,are
R2270	T2746	T2743	dobj	substitution,had
R2271	T2747	T2748	advmod	previously,reported
R2272	T2748	T2746	amod	reported,substitution
R2273	T2749	T2746	punct	(,substitution
R2274	T2750	T2746	appos	A,substitution
R2275	T2751	T2750	prep	to,A
R2276	T2752	T2751	pobj	G,to
R2277	T2753	T2746	punct	", ",substitution
R2278	T2754	T2746	appos	Thr164Ala,substitution
R2279	T2755	T2746	punct	),substitution
R228	T283	T284	nsubj	Age,have
R2280	T2756	T2746	prep	in,substitution
R2281	T2757	T2756	pobj	exon,in
R2282	T2758	T2757	nummod	1,exon
R2283	T2759	T2746	cc	and,substitution
R2284	T2760	T2761	amod	several,changes
R2285	T2761	T2746	conj	changes,substitution
R2286	T2762	T2761	amod	other,changes
R2287	T2763	T2764	amod	single,base
R2288	T2764	T2761	compound	base,changes
R2289	T2765	T2761	prep	in,changes
R229	T285	T283	punct	", ",Age
R2290	T2766	T2767	det	the,region
R2291	T2767	T2765	pobj	region,in
R2292	T2768	T2767	compound	promoter,region
R2293	T2769	T2770	punct	[,22
R2294	T2770	T2743	parataxis	22,had
R2295	T2771	T2770	punct	],22
R2296	T2772	T2743	punct	.,had
R2297	T2774	T2775	det	The,presence
R2298	T2775	T2776	nsubj	presence,associate
R2299	T2777	T2775	cc	or,presence
R23	T57	T53	prep	in,pressure
R230	T286	T283	conj	time,Age
R2300	T2778	T2775	conj	absence,presence
R2301	T2779	T2775	prep	of,presence
R2302	T2780	T2781	det	this,allele
R2303	T2781	T2779	pobj	allele,of
R2304	T2782	T2776	aux	does,associate
R2305	T2783	T2776	neg	not,associate
R2306	T2784	T2776	prep	with,associate
R2307	T2785	T2784	pobj	IOP,with
R2308	T2786	T2787	mark	as,is
R2309	T2787	T2776	advcl	is,associate
R231	T287	T286	prep	of,time
R2310	T2788	T2787	nsubj	it,is
R2311	T2789	T2787	acomp	present,is
R2312	T2790	T2787	prep	in,is
R2313	T2791	T2790	pobj	strains,in
R2314	T2792	T2791	prep	with,strains
R2315	T2793	T2794	det	a,range
R2316	T2794	T2792	pobj	range,with
R2317	T2795	T2794	prep	of,range
R2318	T2796	T2795	pobj	IOPs,of
R2319	T2797	T2798	punct	(,Figure
R232	T288	T287	pobj	day,of
R2320	T2798	T2776	parataxis	Figure,associate
R2321	T2799	T2798	nummod	8,Figure
R2322	T2800	T2798	punct	),Figure
R2323	T2801	T2776	punct	.,associate
R2324	T2891	T3137	punct	),mmHg
R2325	T2892	T3201	dep	that,arose
R2326	T2893	T2894	amod	Genetic,alterations
R2327	T2895	T2894	cc	and,alterations
R2328	T2896	T2894	conj	IOP,alterations
R2329	T2898	T2899	compound	Y,Chromosome
R233	T289	T286	punct	", ",time
R2330	T2901	T2902	det	The,chromosome
R2331	T2902	T2904	nsubjpass	chromosome,implicated
R2332	T2903	T2902	compound	Y,chromosome
R2333	T2905	T2904	aux	has,implicated
R2334	T2906	T2904	auxpass	been,implicated
R2335	T2907	T2904	prep	in,implicated
R2336	T2908	T2909	npadvmod	strain,specific
R2337	T2909	T2910	amod	specific,differences
R2338	T2910	T2907	pobj	differences,in
R2339	T2911	T2912	compound	blood,pressure
R234	T290	T286	conj	obesity,time
R2340	T2912	T2910	compound	pressure,differences
R2341	T2913	T2910	prep	in,differences
R2342	T2914	T2913	pobj	rats,in
R2343	T2915	T2916	punct	[,24
R2344	T2916	T2904	parataxis	24,implicated
R2345	T2917	T2916	nummod	23,24
R2346	T2918	T2916	punct	",",24
R2347	T2919	T2916	punct	],24
R2348	T2920	T2904	punct	.,implicated
R2349	T2922	T2923	aux	To,test
R235	T291	T290	cc	and,obesity
R2350	T2923	T2924	advcl	test,compared
R2351	T2925	T2926	mark	if,alters
R2352	T2926	T2923	ccomp	alters,test
R2353	T2927	T2928	det	the,chromosome
R2354	T2928	T2926	nsubj	chromosome,alters
R2355	T2929	T2928	compound	Y,chromosome
R2356	T2930	T2928	prep	of,chromosome
R2357	T2931	T2932	compound	strain,Ola
R2358	T2932	T2930	pobj	Ola,of
R2359	T2933	T2932	compound	129,Ola
R236	T292	T290	conj	diabetes,obesity
R2360	T2934	T2932	punct	/,Ola
R2361	T2935	T2926	dobj	IOP,alters
R2362	T2936	T2926	prep	in,alters
R2363	T2937	T2936	pobj	relation,in
R2364	T2938	T2937	prep	to,relation
R2365	T2939	T2938	pobj	that,to
R2366	T2940	T2939	prep	of,that
R2367	T2941	T2942	compound	strain,B6
R2368	T2942	T2940	pobj	B6,of
R2369	T2943	T2924	punct	", ",compared
R237	T293	T284	dobj	effects,have
R2370	T2944	T2924	nsubj	we,compared
R2371	T2945	T2946	det	the,IOPs
R2372	T2946	T2924	dobj	IOPs,compared
R2373	T2947	T2946	prep	of,IOPs
R2374	T2948	T2949	amod	pure,males
R2375	T2949	T2947	pobj	males,of
R2376	T2950	T2949	compound	B6,males
R2377	T2951	T2949	cc	and,males
R2378	T2952	T2953	amod	consomic,males
R2379	T2953	T2949	conj	males,males
R238	T294	T293	prep	on,effects
R2380	T2954	T2953	compound	B6,males
R2381	T2955	T2956	dep	that,had
R2382	T2956	T2953	relcl	had,males
R2383	T2957	T2958	det	the,chromosome
R2384	T2958	T2956	dobj	chromosome,had
R2385	T2959	T2960	compound	129P2,Ola
R2386	T2960	T2958	compound	Ola,chromosome
R2387	T2961	T2960	punct	/,Ola
R2388	T2962	T2958	compound	Y,chromosome
R2389	T2963	T2958	punct	(,chromosome
R239	T295	T296	compound	mouse,IOP
R2390	T2964	T2958	acl	backcrossed,chromosome
R2391	T2965	T2964	prep	for,backcrossed
R2392	T2966	T2967	nummod	11,generations
R2393	T2967	T2965	pobj	generations,for
R2394	T2968	T2924	punct	),compared
R2395	T2969	T2924	punct	.,compared
R2396	T2971	T2972	det	No,differences
R2397	T2972	T2973	nsubjpass	differences,detected
R2398	T2974	T2972	prep	in,differences
R2399	T2975	T2974	pobj	IOP,in
R24	T58	T57	pobj	mice,in
R240	T296	T294	pobj	IOP,on
R2400	T2976	T2973	auxpass	were,detected
R2401	T2977	T2973	prep	between,detected
R2402	T2978	T2979	det	these,groups
R2403	T2979	T2977	pobj	groups,between
R2404	T2980	T2979	prep	of,groups
R2405	T2981	T2980	pobj	mice,of
R2406	T2982	T2983	punct	(,Figure
R2407	T2983	T2973	parataxis	Figure,detected
R2408	T2984	T2983	nummod	9,Figure
R2409	T2985	T2983	punct	", ",Figure
R241	T297	T293	amod	similar,effects
R2410	T2986	T2987	nsubj	P,0.1
R2411	T2987	T2983	ccomp	0.1,Figure
R2412	T2988	T2987	punct	=,0.1
R2413	T2989	T2983	punct	),Figure
R2414	T2990	T2973	punct	.,detected
R2415	T2996	T2995	aux	a,r
R2416	T3001	T3002	aux	To,test
R2417	T3002	T3003	advcl	test,analyzed
R2418	T3004	T3005	mark	if,leads
R2419	T3005	T3002	ccomp	leads,test
R242	T298	T297	prep	to,similar
R2420	T3006	T3005	nsubj	deficiency,leads
R2421	T3007	T3006	prep	of,deficiency
R2422	T3008	T3009	amod	carbonic,anhydrase
R2423	T3009	T3007	pobj	anhydrase,of
R2424	T3010	T3009	nummod	II,anhydrase
R2425	T3011	T3005	prep	to,leads
R2426	T3012	T3013	amod	decreased,IOP
R2427	T3013	T3011	pobj	IOP,to
R2428	T3014	T3003	punct	", ",analyzed
R2429	T3015	T3003	nsubj	we,analyzed
R243	T299	T298	pobj	those,to
R2430	T3016	T3003	dobj	mice,analyzed
R2431	T3017	T3016	prep	of,mice
R2432	T3018	T3019	det	a,background
R2433	T3019	T3017	pobj	background,of
R2434	T3020	T3019	compound	B6,background
R2435	T3021	T3022	dep	that,were
R2436	T3022	T3016	relcl	were,mice
R2437	T3023	T3024	advmod	genetically,similar
R2438	T3024	T3022	acomp	similar,were
R2439	T3025	T3024	cc	but,similar
R244	T300	T299	prep	in,those
R2440	T3026	T3024	conj	with,similar
R2441	T3027	T3028	amod	normal,alleles
R2442	T3028	T3026	pobj	alleles,with
R2443	T3029	T3027	cc	or,normal
R2444	T3030	T3027	conj	mutant,normal
R2445	T3031	T3028	prep	of,alleles
R2446	T3032	T3033	det	the,gene
R2447	T3033	T3031	pobj	gene,of
R2448	T3034	T3033	compound	Car2,gene
R2449	T3035	T3036	punct	[,26
R245	T301	T300	pobj	humans,in
R2450	T3036	T3003	parataxis	26,analyzed
R2451	T3037	T3036	nummod	25,26
R2452	T3038	T3036	punct	",",26
R2453	T3039	T3036	punct	],26
R2454	T3040	T3003	punct	.,analyzed
R2455	T3042	T3043	expl	There,was
R2456	T3044	T3045	det	no,difference
R2457	T3045	T3043	attr	difference,was
R2458	T3046	T3045	prep	in,difference
R2459	T3047	T3046	pobj	IOP,in
R246	T302	T301	cc	and,humans
R2460	T3048	T3043	prep	between,was
R2461	T3049	T3050	amod	normal,mice
R2462	T3050	T3048	pobj	mice,between
R2463	T3051	T3049	cc	and,normal
R2464	T3052	T3049	conj	mutant,normal
R2465	T3053	T3054	punct	(,Figure
R2466	T3054	T3043	parataxis	Figure,was
R2467	T3055	T3054	nummod	9,Figure
R2468	T3056	T3054	punct	", ",Figure
R2469	T3057	T3058	nsubj	P,0.5
R247	T303	T304	amod	other,species
R2470	T3058	T3054	ccomp	0.5,Figure
R2471	T3059	T3058	punct	=,0.5
R2472	T3060	T3054	punct	),Figure
R2473	T3061	T3043	punct	.,was
R2474	T3065	T3066	aux	To,test
R2475	T3066	T3067	advcl	test,compared
R2476	T3068	T3069	mark	if,alter
R2477	T3069	T3066	ccomp	alter,test
R2478	T3070	T3071	amod	genetic,perturbations
R2479	T3071	T3069	nsubj	perturbations,alter
R248	T304	T301	conj	species,humans
R2480	T3072	T3073	dep	that,cause
R2481	T3073	T3071	relcl	cause,perturbations
R2482	T3074	T3073	dobj	obesity,cause
R2483	T3075	T3074	cc	and,obesity
R2484	T3076	T3074	conj	diabetes,obesity
R2485	T3077	T3069	aux	can,alter
R2486	T3078	T3069	dobj	IOP,alter
R2487	T3079	T3067	punct	", ",compared
R2488	T3080	T3067	nsubj	we,compared
R2489	T3081	T3067	dobj	mice,compared
R249	T305	T284	punct	.,have
R2490	T3082	T3083	dep	that,were
R2491	T3083	T3081	relcl	were,mice
R2492	T3084	T3085	advmod	genetically,similar
R2493	T3085	T3083	acomp	similar,were
R2494	T3086	T3083	cc	but,were
R2495	T3087	T3083	conj	were,were
R2496	T3088	T3089	preconj	either,homozygous
R2497	T3089	T3087	acomp	homozygous,were
R2498	T3090	T3089	cc	or,homozygous
R2499	T3091	T3089	conj	heterozygous,homozygous
R25	T59	T58	cc	and,mice
R250	T307	T308	nsubj	Mutations,result
R2500	T3092	T3091	prep	for,heterozygous
R2501	T3093	T3094	det	a,mutation
R2502	T3094	T3092	pobj	mutation,for
R2503	T3095	T3096	compound	leptin,receptor
R2504	T3096	T3094	compound	receptor,mutation
R2505	T3097	T3094	punct	(,mutation
R2506	T3098	T3094	appos	db,mutation
R2507	T3099	T3094	punct	),mutation
R2508	T3100	T3101	dep	that,results
R2509	T3101	T3094	relcl	results,mutation
R251	T309	T307	prep	in,Mutations
R2510	T3102	T3101	prep	in,results
R2511	T3103	T3102	pobj	obesity,in
R2512	T3104	T3103	cc	and,obesity
R2513	T3105	T3103	conj	diabetes,obesity
R2514	T3106	T3101	prep	before,results
R2515	T3107	T3108	nummod	4,months
R2516	T3108	T3106	pobj	months,before
R2517	T3109	T3108	prep	of,months
R2518	T3110	T3109	pobj	age,of
R2519	T3111	T3101	prep	on,results
R252	T310	T309	pobj	two,in
R2520	T3112	T3113	det	the,background
R2521	T3113	T3111	pobj	background,on
R2522	T3114	T3115	compound	C57BLKS,J
R2523	T3115	T3117	compound	J,strain
R2524	T3116	T3115	punct	/,J
R2525	T3117	T3113	compound	strain,background
R2526	T3118	T3113	acl	used,background
R2527	T3119	T3120	punct	[,27
R2528	T3120	T3067	parataxis	27,compared
R2529	T3121	T3120	punct	],27
R253	T311	T310	prep	of,two
R2530	T3122	T3067	punct	.,compared
R2531	T3124	T3125	nsubj	IOP,was
R2532	T3126	T3125	advmod	modestly,was
R2533	T3127	T3126	cc	but,modestly
R2534	T3128	T3126	conj	significantly,modestly
R2535	T3129	T3125	acomp	elevated,was
R2536	T3130	T3125	prep	in,was
R2537	T3131	T3132	amod	obese,mutants
R2538	T3132	T3130	pobj	mutants,in
R2539	T3133	T3132	punct	", ",mutants
R254	T312	T313	det	the,genes
R2540	T3134	T3132	amod	diabetic,mutants
R2541	T3135	T3132	amod	homozygous,mutants
R2542	T3136	T3137	punct	(,mmHg
R2543	T3137	T3132	parataxis	mmHg,mutants
R2544	T3138	T3139	quantmod	14.7,0.3
R2545	T3139	T3137	nummod	0.3,mmHg
R2546	T3140	T3139	punct	±,0.3
R2547	T3141	T3125	prep	compared,was
R2548	T3142	T3141	prep	to,compared
R2549	T3143	T3144	amod	non-obese,heterozygotes
R255	T313	T311	pobj	genes,of
R2550	T3144	T3142	pobj	heterozygotes,to
R2551	T3145	T3144	punct	", ",heterozygotes
R2552	T3146	T3144	amod	non-diabetic,heterozygotes
R2553	T3147	T3148	punct	(,Figure
R2554	T3148	T3144	parataxis	Figure,heterozygotes
R2555	T3149	T3150	quantmod	13.4,0.4
R2556	T3150	T3152	nummod	0.4,mmHg
R2557	T3151	T3150	punct	±,0.4
R2558	T3152	T3148	dep	mmHg,Figure
R2559	T3153	T3148	punct	", ",Figure
R256	T314	T313	amod	assessed,genes
R2560	T3154	T3155	nsubj	P,0.01
R2561	T3155	T3148	ccomp	0.01,Figure
R2562	T3156	T3155	punct	<,0.01
R2563	T3157	T3148	punct	", ",Figure
R2564	T3158	T3148	nummod	9,Figure
R2565	T3159	T3148	punct	),Figure
R2566	T3160	T3125	punct	.,was
R2567	T3164	T3165	aux	To,determine
R2568	T3165	T3166	advcl	determine,analyzed
R2569	T3167	T3168	mark	if,alters
R257	T315	T313	compound	candidate,genes
R2570	T3168	T3165	ccomp	alters,determine
R2571	T3169	T3168	nsubj	albinism,alters
R2572	T3170	T3168	dobj	IOP,alters
R2573	T3171	T3166	punct	", ",analyzed
R2574	T3172	T3166	nsubj	we,analyzed
R2575	T3173	T3174	compound	B6,mice
R2576	T3174	T3166	dobj	mice,analyzed
R2577	T3175	T3176	dep	that,were
R2578	T3176	T3174	relcl	were,mice
R2579	T3177	T3178	preconj	either,pigmented
R258	T316	T310	punct	(,two
R2580	T3178	T3176	amod	pigmented,were
R2581	T3179	T3178	cc	or,pigmented
R2582	T3180	T3178	conj	albino,pigmented
R2583	T3181	T3166	punct	.,analyzed
R2584	T3183	T3184	det	The,mice
R2585	T3184	T3186	nsubj	mice,were
R2586	T3185	T3184	compound	albino,mice
R2587	T3187	T3186	acomp	homozygous,were
R2588	T3188	T3187	cc	and,homozygous
R2589	T3189	T3187	conj	coisogenic,homozygous
R259	T317	T310	appos	Lepr,two
R2590	T3190	T3189	prep	for,coisogenic
R2591	T3191	T3192	det	a,allele
R2592	T3192	T3190	pobj	allele,for
R2593	T3193	T3192	amod	mutant,allele
R2594	T3194	T3192	prep	of,allele
R2595	T3195	T3194	pobj	tyrosinase,of
R2596	T3196	T3195	punct	(,tyrosinase
R2597	T3197	T3198	compound	Tyrc,2J
R2598	T3198	T3195	appos	2J,tyrosinase
R2599	T3199	T3198	punct	-,2J
R26	T60	T61	amod	other,mammals
R260	T318	T317	cc	and,Lepr
R2600	T3200	T3195	punct	),tyrosinase
R2601	T3201	T3195	relcl	arose,tyrosinase
R2602	T3202	T3201	prep	on,arose
R2603	T3203	T3204	det	the,background
R2604	T3204	T3202	pobj	background,on
R2605	T3205	T3206	advmod	otherwise,pigmented
R2606	T3206	T3204	amod	pigmented,background
R2607	T3207	T3204	compound	B6,background
R2608	T3208	T3186	punct	.,were
R2609	T3210	T3211	prep	In,resulted
R261	T319	T317	conj	Tyr,Lepr
R2610	T3212	T3213	nummod	2,month
R2611	T3213	T3214	npadvmod	month,old
R2612	T3214	T3215	amod	old,mice
R2613	T3215	T3210	pobj	mice,In
R2614	T3216	T3211	punct	", ",resulted
R2615	T3217	T3211	nsubj	homozygosity,resulted
R2616	T3218	T3217	prep	for,homozygosity
R2617	T3219	T3220	compound	Tyrc,2J
R2618	T3220	T3218	pobj	2J,for
R2619	T3221	T3220	punct	-,2J
R262	T320	T308	punct	),result
R2620	T3222	T3211	prep	in,resulted
R2621	T3223	T3224	amod	increased,IOP
R2622	T3224	T3222	pobj	IOP,in
R2623	T3225	T3226	punct	(,mmHg
R2624	T3226	T3224	parataxis	mmHg,IOP
R2625	T3227	T3228	quantmod	14.2,0.4
R2626	T3228	T3226	nummod	0.4,mmHg
R2627	T3229	T3228	punct	±,0.4
R2628	T3230	T3226	punct	),mmHg
R2629	T3231	T3211	prep	compared,resulted
R263	T321	T308	prep	in,result
R2630	T3232	T3231	prep	to,compared
R2631	T3233	T3234	amod	wild,type
R2632	T3234	T3235	nmod	type,mice
R2633	T3235	T3232	pobj	mice,to
R2634	T3236	T3235	punct	", ",mice
R2635	T3237	T3235	amod	pigmented,mice
R2636	T3238	T3239	punct	(,mmHg
R2637	T3239	T3235	parataxis	mmHg,mice
R2638	T3240	T3241	quantmod	12.4,0.3
R2639	T3241	T3239	nummod	0.3,mmHg
R264	T322	T323	amod	increased,IOP
R2640	T3242	T3241	punct	±,0.3
R2641	T3243	T3239	punct	", ",mmHg
R2642	T3244	T3245	nsubj	P,0.0001
R2643	T3245	T3239	ccomp	0.0001,mmHg
R2644	T3246	T3245	punct	<,0.0001
R2645	T3247	T3239	punct	),mmHg
R2646	T3248	T3211	punct	.,resulted
R2647	T3250	T3251	det	The,same
R2648	T3251	T3252	nsubj	same,was
R2649	T3253	T3252	acomp	true,was
R265	T323	T321	pobj	IOP,in
R2650	T3254	T3252	prep	for,was
R2651	T3255	T3256	amod	independent,cohorts
R2652	T3256	T3254	pobj	cohorts,for
R2653	T3257	T3256	prep	of,cohorts
R2654	T3258	T3257	pobj	mice,of
R2655	T3259	T3258	prep	of,mice
R2656	T3260	T3261	amod	different,ages
R2657	T3261	T3259	pobj	ages,of
R2658	T3262	T3263	dep	that,analyzed
R2659	T3263	T3258	relcl	analyzed,mice
R266	T324	T308	punct	.,result
R2660	T3264	T3263	auxpass	were,analyzed
R2661	T3265	T3263	prep	at,analyzed
R2662	T3266	T3267	amod	different,times
R2663	T3267	T3265	pobj	times,at
R2664	T3268	T3269	punct	(,10A
R2665	T3269	T3252	parataxis	10A,was
R2666	T3270	T3269	compound	Figure,10A
R2667	T3271	T3269	punct	),10A
R2668	T3272	T3252	punct	.,was
R2669	T3274	T3275	prep	In,were
R267	T326	T327	det	These,studies
R2670	T3276	T3274	pobj	contrast,In
R2671	T3277	T3276	prep	to,contrast
R2672	T3278	T3279	amod	pigmented,mice
R2673	T3279	T3277	pobj	mice,to
R2674	T3280	T3279	compound	B6,mice
R2675	T3281	T3282	punct	(,Figure
R2676	T3282	T3279	parataxis	Figure,mice
R2677	T3283	T3282	nummod	6,Figure
R2678	T3284	T3282	punct	),Figure
R2679	T3285	T3275	punct	", ",were
R268	T327	T328	nsubj	studies,demonstrate
R2680	T3286	T3287	det	the,IOPs
R2681	T3287	T3275	nsubj	IOPs,were
R2682	T3288	T3287	prep	of,IOPs
R2683	T3289	T3290	det	the,mice
R2684	T3290	T3288	pobj	mice,of
R2685	T3291	T3290	compound	albino,mice
R2686	T3292	T3290	compound	B6,mice
R2687	T3293	T3275	neg	not,were
R2688	T3294	T3275	acomp	increased,were
R2689	T3295	T3275	prep	at,were
R269	T329	T330	mark	that,are
R2690	T3296	T3295	pobj	measurement,at
R2691	T3297	T3296	prep	during,measurement
R2692	T3298	T3299	det	the,dark
R2693	T3299	T3297	pobj	dark,during
R2694	T3300	T3299	prep	compared,dark
R2695	T3301	T3300	prep	to,compared
R2696	T3302	T3301	pobj	light,to
R2697	T3303	T3299	appos	period,dark
R2698	T3304	T3303	prep	of,period
R2699	T3305	T3306	det	the,day
R27	T61	T58	conj	mammals,mice
R270	T330	T328	ccomp	are,demonstrate
R2700	T3306	T3304	pobj	day,of
R2701	T3307	T3308	punct	(,10B
R2702	T3308	T3275	parataxis	10B,were
R2703	T3309	T3310	nsubj	P,0.6
R2704	T3310	T3308	ccomp	0.6,10B
R2705	T3311	T3310	punct	=,0.6
R2706	T3312	T3308	punct	", ",10B
R2707	T3313	T3308	compound	Figure,10B
R2708	T3314	T3308	punct	),10B
R2709	T3315	T3275	punct	.,were
R271	T331	T330	nsubj	mice,are
R2710	T3401	T3402	compound	IOP,differences
R2711	T3402	T3403	nsubj	differences,are
R2712	T3404	T3403	acomp	reproducible,are
R2713	T3405	T3404	cc	and,reproducible
R2714	T3406	T3404	conj	amenable,reproducible
R2715	T3407	T3406	prep	to,amenable
R2716	T3408	T3409	amod	genetic,analyses
R2717	T3409	T3407	pobj	analyses,to
R2718	T3411	T3412	nsubj	We,report
R2719	T3413	T3414	det	the,IOPs
R272	T332	T333	det	a,system
R2720	T3414	T3412	dobj	IOPs,report
R2721	T3415	T3414	prep	of,IOPs
R2722	T3416	T3417	quantmod	over,30
R2723	T3417	T3418	nummod	30,strains
R2724	T3418	T3415	pobj	strains,of
R2725	T3419	T3420	advmod	genetically,different
R2726	T3420	T3418	amod	different,strains
R2727	T3421	T3418	compound	mouse,strains
R2728	T3422	T3423	dep	that,housed
R2729	T3423	T3418	relcl	housed,strains
R273	T333	T330	attr	system,are
R2730	T3424	T3423	auxpass	were,housed
R2731	T3425	T3423	prep	in,housed
R2732	T3426	T3427	det	the,conditions
R2733	T3427	T3425	pobj	conditions,in
R2734	T3428	T3427	amod	same,conditions
R2735	T3429	T3427	amod	environmental,conditions
R2736	T3430	T3412	punct	.,report
R2737	T3432	T3433	det	The,magnitude
R2738	T3433	T3434	nsubj	magnitude,allow
R2739	T3435	T3433	prep	of,magnitude
R274	T334	T333	amod	practical,system
R2740	T3436	T3437	compound	IOP,differences
R2741	T3437	T3435	pobj	differences,of
R2742	T3438	T3437	prep	between,differences
R2743	T3439	T3438	pobj	strains,between
R2744	T3440	T3433	cc	and,magnitude
R2745	T3441	T3442	det	the,reproducibility
R2746	T3442	T3433	conj	reproducibility,magnitude
R2747	T3443	T3442	amod	good,reproducibility
R2748	T3444	T3442	prep	of,reproducibility
R2749	T3445	T3444	pobj	readings,of
R275	T335	T334	cc	and,practical
R2750	T3446	T3442	prep	over,reproducibility
R2751	T3447	T3446	pobj	time,over
R2752	T3448	T3434	aux	will,allow
R2753	T3449	T3450	det	the,use
R2754	T3450	T3434	dobj	use,allow
R2755	T3451	T3450	prep	of,use
R2756	T3452	T3453	amod	genetic,approaches
R2757	T3453	T3451	pobj	approaches,of
R2758	T3454	T3455	aux	to,identify
R2759	T3455	T3450	advcl	identify,use
R276	T336	T334	conj	powerful,practical
R2760	T3456	T3455	dobj	genes,identify
R2761	T3457	T3458	dep	that,underlie
R2762	T3458	T3456	relcl	underlie,genes
R2763	T3459	T3460	det	these,differences
R2764	T3460	T3458	dobj	differences,underlie
R2765	T3461	T3434	punct	.,allow
R2766	T3463	T3464	advcl	Using,measure
R2767	T3465	T3466	poss	our,method
R2768	T3466	T3463	dobj	method,Using
R2769	T3467	T3464	punct	", ",measure
R277	T337	T333	amod	experimental,system
R2770	T3468	T3469	det	a,investigator
R2771	T3469	T3464	nsubj	investigator,measure
R2772	T3470	T3469	amod	trained,investigator
R2773	T3471	T3464	aux	can,measure
R2774	T3472	T3473	det	the,IOPs
R2775	T3473	T3464	dobj	IOPs,measure
R2776	T3474	T3473	prep	of,IOPs
R2777	T3475	T3476	nummod	10,mice
R2778	T3476	T3474	pobj	mice,of
R2779	T3477	T3464	prep	in,measure
R278	T338	T339	aux	to,study
R2780	T3478	T3479	det	an,hour
R2781	T3479	T3477	pobj	hour,in
R2782	T3480	T3464	punct	.,measure
R2783	T3482	T3483	advmod	Thus,is
R2784	T3484	T3483	nsubj	it,is
R2785	T3485	T3483	acomp	feasible,is
R2786	T3486	T3487	aux	to,assess
R2787	T3487	T3483	xcomp	assess,is
R2788	T3488	T3489	amod	sufficient,numbers
R2789	T3489	T3487	dobj	numbers,assess
R279	T339	T333	advcl	study,system
R2790	T3490	T3489	prep	of,numbers
R2791	T3491	T3490	pobj	mice,of
R2792	T3492	T3487	prep	for,assess
R2793	T3493	T3494	amod	quantitative,locus
R2794	T3494	T3496	nmod	locus,methods
R2795	T3495	T3494	nmod	trait,locus
R2796	T3496	T3492	pobj	methods,for
R2797	T3497	T3494	punct	(,locus
R2798	T3498	T3494	appos	QTL,locus
R2799	T3499	T3494	punct	),locus
R28	T62	T46	punct	.,known
R280	T340	T341	det	the,genetics
R2800	T3500	T3496	compound	analysis,methods
R2801	T3501	T3487	cc	and,assess
R2802	T3502	T3503	aux	to,use
R2803	T3503	T3487	conj	use,assess
R2804	T3504	T3505	det	these,methods
R2805	T3505	T3503	dobj	methods,use
R2806	T3506	T3507	aux	to,identify
R2807	T3507	T3503	advcl	identify,use
R2808	T3508	T3509	amod	chromosomal,regions
R2809	T3509	T3507	dobj	regions,identify
R281	T341	T339	dobj	genetics,study
R2810	T3510	T3509	acl	contributing,regions
R2811	T3511	T3510	prep	to,contributing
R2812	T3512	T3513	compound	strain,differences
R2813	T3513	T3511	pobj	differences,to
R2814	T3514	T3513	prep	in,differences
R2815	T3515	T3514	pobj	IOP,in
R2816	T3516	T3483	punct	.,is
R2817	T3518	T3519	det	The,survey
R2818	T3519	T3521	nsubj	survey,provides
R2819	T3520	T3519	compound	strain,survey
R282	T342	T341	prep	of,genetics
R2820	T3522	T3523	nsubj	we,report
R2821	T3523	T3519	advcl	report,survey
R2822	T3524	T3525	amod	valuable,information
R2823	T3525	T3521	dobj	information,provides
R2824	T3526	T3521	prep	for,provides
R2825	T3527	T3526	pcomp	designing,for
R2826	T3528	T3529	det	these,experiments
R2827	T3529	T3527	dobj	experiments,designing
R2828	T3530	T3521	punct	.,provides
R2829	T3532	T3533	det	The,throughput
R283	T343	T344	compound	IOP,regulation
R2830	T3533	T3534	nsubj	throughput,is
R2831	T3535	T3533	cc	and,throughput
R2832	T3536	T3533	conj	reproducibility,throughput
R2833	T3537	T3534	advmod	also,is
R2834	T3538	T3534	acomp	sufficient,is
R2835	T3539	T3534	prep	for,is
R2836	T3540	T3541	compound	mutagenesis,screens
R2837	T3541	T3539	pobj	screens,for
R2838	T3542	T3543	punct	[,30
R2839	T3543	T3534	parataxis	30,is
R284	T344	T342	pobj	regulation,of
R2840	T3544	T3543	nummod	28,30
R2841	T3545	T3543	punct	-,30
R2842	T3546	T3543	punct	],30
R2843	T3547	T3534	punct	.,is
R2844	T3549	T3550	nsubj	These,are
R2845	T3551	T3552	amod	important,approaches
R2846	T3552	T3550	attr	approaches,are
R2847	T3553	T3554	mark	as,allow
R2848	T3554	T3550	advcl	allow,are
R2849	T3555	T3554	nsubj	they,allow
R285	T345	T344	cc	and,regulation
R2850	T3556	T3554	aux	may,allow
R2851	T3557	T3558	det	the,association
R2852	T3558	T3554	dobj	association,allow
R2853	T3559	T3558	prep	of,association
R2854	T3560	T3559	pobj	genes,of
R2855	T3561	T3558	prep	with,association
R2856	T3562	T3561	pobj	IOP,with
R2857	T3563	T3562	cc	and,IOP
R2858	T3564	T3562	conj	glaucoma,IOP
R2859	T3565	T3566	poss	whose,functions
R286	T346	T347	compound	disease,processes
R2860	T3566	T3569	dep	functions,suggest
R2861	T3567	T3568	advmod	currently,known
R2862	T3568	T3566	amod	known,functions
R2863	T3569	T3558	relcl	suggest,association
R2864	T3570	T3569	aux	do,suggest
R2865	T3571	T3569	neg	not,suggest
R2866	T3572	T3573	mark	that,affect
R2867	T3573	T3569	ccomp	affect,suggest
R2868	T3574	T3573	nsubj	they,affect
R2869	T3575	T3576	amod	aqueous,humor
R287	T347	T344	conj	processes,regulation
R2870	T3576	T3577	compound	humor,dynamics
R2871	T3577	T3573	dobj	dynamics,affect
R2872	T3578	T3573	cc	or,affect
R2873	T3579	T3580	aux	do,identify
R2874	T3580	T3573	conj	identify,affect
R2875	T3581	T3580	neg	not,identify
R2876	T3582	T3580	advmod	immediately,identify
R2877	T3583	T3580	dobj	them,identify
R2878	T3584	T3580	prep	as,identify
R2879	T3585	T3586	amod	likely,candidates
R288	T348	T349	dep	that,raise
R2880	T3586	T3584	pobj	candidates,as
R2881	T3587	T3586	compound	glaucoma,candidates
R2882	T3588	T3550	punct	.,are
R2883	T3628	T3629	det	No,effect
R2884	T3630	T3629	prep	of,effect
R2885	T3631	T3632	amod	anesthetic,protocol
R2886	T3632	T3630	pobj	protocol,of
R2887	T3633	T3629	prep	on,effect
R2888	T3634	T3633	pobj	IOP,on
R2889	T3635	T3629	prep	during,effect
R289	T349	T344	relcl	raise,regulation
R2890	T3636	T3637	det	a,window
R2891	T3637	T3635	pobj	window,during
R2892	T3638	T3639	nummod	12,minute
R2893	T3639	T3637	compound	minute,window
R2894	T3640	T3637	compound	measurement,window
R2895	T3642	T3643	amod	Many,agents
R2896	T3643	T3645	nsubj	agents,lower
R2897	T3644	T3643	amod	anesthetic,agents
R2898	T3646	T3643	prep	including,agents
R2899	T3647	T3646	pobj	xylazine,including
R29	T64	T65	det	The,purpose
R290	T350	T349	dobj	IOP,raise
R2900	T3648	T3645	dobj	IOP,lower
R2901	T3649	T3645	punct	.,lower
R2902	T3651	T3652	nsubj	Ketamine,appears
R2903	T3653	T3652	advmod	usually,appears
R2904	T3654	T3655	aux	to,increase
R2905	T3655	T3652	xcomp	increase,appears
R2906	T3656	T3655	dobj	IOP,increase
R2907	T3657	T3658	punct	[,33
R2908	T3658	T3652	parataxis	33,appears
R2909	T3659	T3658	nummod	31,33
R291	T351	T349	prep	to,raise
R2910	T3660	T3658	punct	-,33
R2911	T3661	T3658	punct	],33
R2912	T3662	T3652	punct	", ",appears
R2913	T3663	T3652	cc	but,appears
R2914	T3664	T3665	expl	there,are
R2915	T3665	T3652	conj	are,appears
R2916	T3666	T3665	attr	reports,are
R2917	T3667	T3666	prep	of,reports
R2918	T3668	T3669	nsubj	ketamine,reducing
R2919	T3669	T3667	pcomp	reducing,of
R292	T352	T353	amod	harmful,levels
R2920	T3670	T3671	amod	having,effect
R2921	T3671	T3669	dative	effect,reducing
R2922	T3672	T3671	det	no,effect
R2923	T3673	T3671	prep	on,effect
R2924	T3674	T3673	pobj	IOP,on
R2925	T3675	T3669	cc	or,reducing
R2926	T3676	T3669	advmod	even,reducing
R2927	T3677	T3669	dobj	IOP,reducing
R2928	T3678	T3679	punct	[,34
R2929	T3679	T3665	parataxis	34,are
R293	T353	T351	pobj	levels,to
R2930	T3680	T3679	nummod	31,34
R2931	T3681	T3679	punct	",",34
R2932	T3682	T3679	punct	],34
R2933	T3683	T3665	punct	.,are
R2934	T3685	T3686	amod	Different,doses
R2935	T3686	T3687	nsubj	doses,contribute
R2936	T3688	T3686	punct	", ",doses
R2937	T3689	T3686	conj	species,doses
R2938	T3690	T3689	acl	used,species
R2939	T3691	T3689	punct	", ",species
R294	T354	T328	punct	.,demonstrate
R2940	T3692	T3689	conj	routes,species
R2941	T3693	T3692	prep	of,routes
R2942	T3694	T3693	pobj	administration,of
R2943	T3695	T3692	cc	or,routes
R2944	T3696	T3692	conj	environments,routes
R2945	T3697	T3687	aux	may,contribute
R2946	T3698	T3687	prep	to,contribute
R2947	T3699	T3700	det	these,differences
R2948	T3700	T3698	pobj	differences,to
R2949	T3701	T3687	punct	.,contribute
R295	T445	T446	nsubj	Glaucoma,is
R2950	T3703	T3704	det	The,relationship
R2951	T3704	T3705	nsubj	relationship,depends
R2952	T3706	T3704	prep	between,relationship
R2953	T3707	T3708	det	the,IOPs
R2954	T3708	T3706	pobj	IOPs,between
R2955	T3709	T3710	nsubj	we,measure
R2956	T3710	T3708	advcl	measure,IOPs
R2957	T3711	T3708	cc	and,IOPs
R2958	T3712	T3708	conj	those,IOPs
R2959	T3713	T3712	prep	in,those
R296	T447	T448	det	a,cause
R2960	T3714	T3715	amod	conscious,mice
R2961	T3715	T3713	pobj	mice,in
R2962	T3716	T3705	prep	upon,depends
R2963	T3717	T3718	det	the,effect
R2964	T3718	T3716	pobj	effect,upon
R2965	T3719	T3718	prep	of,effect
R2966	T3720	T3721	poss	our,protocol
R2967	T3721	T3719	pobj	protocol,of
R2968	T3722	T3721	amod	anesthetic,protocol
R2969	T3723	T3721	punct	(,protocol
R297	T448	T446	attr	cause,is
R2970	T3724	T3725	amod	intraperitoneal,injection
R2971	T3725	T3721	appos	injection,protocol
R2972	T3726	T3725	prep	of,injection
R2973	T3727	T3728	nummod	99,mg
R2974	T3728	T3729	nmod	mg,ketamine
R2975	T3729	T3726	pobj	ketamine,of
R2976	T3730	T3731	punct	/,kg
R2977	T3731	T3728	prep	kg,mg
R2978	T3732	T3729	cc	and,ketamine
R2979	T3733	T3734	nummod	9,mg
R298	T449	T448	amod	leading,cause
R2980	T3734	T3735	nmod	mg,xylazine
R2981	T3735	T3729	conj	xylazine,ketamine
R2982	T3736	T3737	punct	/,kg
R2983	T3737	T3734	prep	kg,mg
R2984	T3738	T3705	punct	),depends
R2985	T3739	T3705	punct	.,depends
R2986	T3741	T3742	det	An,effect
R2987	T3742	T3744	nsubj	effect,alter
R2988	T3743	T3742	amod	anesthetic,effect
R2989	T3745	T3744	aux	could,alter
R299	T450	T448	prep	of,cause
R2990	T3746	T3744	advmod	potentially,alter
R2991	T3747	T3744	dobj	IOP,alter
R2992	T3748	T3744	cc	and,alter
R2993	T3749	T3744	conj	mask,alter
R2994	T3750	T3751	advmod	genetically,determined
R2995	T3751	T3752	amod	determined,differences
R2996	T3752	T3749	dobj	differences,mask
R2997	T3753	T3752	prep	in,differences
R2998	T3754	T3753	pobj	IOP,in
R2999	T3755	T3744	punct	.,alter
R3	T32	T29	prep	in,pressure
R30	T65	T66	nsubj	purpose,was
R300	T451	T450	pobj	blindness,of
R3000	T3757	T3758	advmod	Therefore,is
R3001	T3759	T3758	punct	", ",is
R3002	T3760	T3758	nsubj	it,is
R3003	T3761	T3762	advmod	very,important
R3004	T3762	T3758	acomp	important,is
R3005	T3763	T3764	aux	to,understand
R3006	T3764	T3758	xcomp	understand,is
R3007	T3765	T3766	det	this,effect
R3008	T3766	T3764	dobj	effect,understand
R3009	T3767	T3758	punct	.,is
R301	T452	T446	cc	but,is
R3010	T3769	T3770	advmod	Here,show
R3011	T3771	T3770	punct	", ",show
R3012	T3772	T3770	nsubj	we,show
R3013	T3773	T3774	mark	that,has
R3014	T3774	T3770	ccomp	has,show
R3015	T3775	T3774	punct	", ",has
R3016	T3776	T3774	prep	despite,has
R3017	T3777	T3778	det	a,effect
R3018	T3778	T3776	pobj	effect,despite
R3019	T3779	T3778	compound	depressant,effect
R302	T453	T454	poss	its,etiology
R3020	T3780	T3778	prep	on,effect
R3021	T3781	T3780	pobj	IOP,on
R3022	T3782	T3778	prep	by,effect
R3023	T3783	T3784	nummod	25,minutes
R3024	T3784	T3782	pobj	minutes,by
R3025	T3785	T3774	punct	", ",has
R3026	T3786	T3787	poss	our,protocol
R3027	T3787	T3774	nsubj	protocol,has
R3028	T3788	T3787	amod	anesthetic,protocol
R3029	T3789	T3790	det	no,effect
R303	T454	T456	nsubj	etiology,is
R3030	T3790	T3774	dobj	effect,has
R3031	T3791	T3790	amod	detectable,effect
R3032	T3792	T3774	prep	on,has
R3033	T3793	T3792	pobj	IOP,on
R3034	T3794	T3774	prep	during,has
R3035	T3795	T3796	quantmod	the,12
R3036	T3796	T3798	nummod	12,minutes
R3037	T3797	T3796	amod	first,12
R3038	T3798	T3794	pobj	minutes,during
R3039	T3799	T3798	prep	after,minutes
R304	T455	T454	amod	molecular,etiology
R3040	T3800	T3799	pobj	administration,after
R3041	T3801	T3770	punct	.,show
R3042	T3803	T3804	advmod	Thus,made
R3043	T3805	T3804	punct	", ",made
R3044	T3806	T3807	aux	to,avoid
R3045	T3807	T3804	advcl	avoid,made
R3046	T3808	T3807	dobj	effects,avoid
R3047	T3809	T3808	prep	of,effects
R3048	T3810	T3809	pobj	anesthesia,of
R3049	T3811	T3808	prep	on,effects
R305	T456	T446	conj	is,is
R3050	T3812	T3811	pobj	IOP,on
R3051	T3813	T3804	punct	", ",made
R3052	T3814	T3815	det	all,measurements
R3053	T3815	T3804	nsubjpass	measurements,made
R3054	T3816	T3804	aux	should,made
R3055	T3817	T3804	auxpass	be,made
R3056	T3818	T3804	prep	within,made
R3057	T3819	T3820	det	a,window
R3058	T3820	T3818	pobj	window,within
R3059	T3821	T3820	prep	of,window
R306	T457	T458	advmod	poorly,understood
R3060	T3822	T3823	quantmod	up,12
R3061	T3823	T3825	nummod	12,minutes
R3062	T3824	T3823	quantmod	to,12
R3063	T3825	T3821	pobj	minutes,of
R3064	T3826	T3825	prep	after,minutes
R3065	T3827	T3828	amod	anesthetic,administration
R3066	T3828	T3826	pobj	administration,after
R3067	T3829	T3804	punct	.,made
R3068	T3832	T3831	cc	and,Similarities
R3069	T3833	T3831	conj	differences,Similarities
R307	T458	T456	acomp	understood,is
R3070	T3834	T3831	prep	to,Similarities
R3071	T3835	T3836	compound	rat,studies
R3072	T3836	T3834	pobj	studies,to
R3073	T3838	T3839	poss	Our,results
R3074	T3839	T3840	nsubj	results,agree
R3075	T3841	T3840	prep	with,agree
R3076	T3842	T3843	det	the,course
R3077	T3843	T3841	pobj	course,with
R3078	T3844	T3843	compound	time,course
R3079	T3845	T3843	prep	of,course
R308	T459	T456	punct	.,is
R3080	T3846	T3847	amod	cardiovascular,depression
R3081	T3847	T3845	pobj	depression,of
R3082	T3848	T3847	acl	caused,depression
R3083	T3849	T3848	agent	by,caused
R3084	T3850	T3851	amod	intraperitoneal,administration
R3085	T3851	T3849	pobj	administration,by
R3086	T3852	T3851	prep	of,administration
R3087	T3853	T3852	pobj	ketamine,of
R3088	T3854	T3853	cc	and,ketamine
R3089	T3855	T3853	conj	xylazine,ketamine
R309	T461	T462	nsubj	Glaucoma,involves
R3090	T3856	T3851	prep	in,administration
R3091	T3857	T3856	pobj	rats,in
R3092	T3858	T3840	punct	.,agree
R3093	T3860	T3861	prep	In,had
R3094	T3862	T3863	det	that,study
R3095	T3863	T3860	pobj	study,In
R3096	T3864	T3861	punct	", ",had
R3097	T3865	T3861	nsubj	anesthesia,had
R3098	T3866	T3867	det	a,effect
R3099	T3867	T3861	dobj	effect,had
R31	T67	T65	prep	of,purpose
R310	T463	T464	amod	retinal,ganglion
R3100	T3868	T3867	amod	minor,effect
R3101	T3869	T3867	prep	on,effect
R3102	T3870	T3871	compound	blood,pressure
R3103	T3871	T3869	pobj	pressure,on
R3104	T3872	T3867	prep	during,effect
R3105	T3873	T3874	quantmod	the,15
R3106	T3874	T3876	nummod	15,minutes
R3107	T3875	T3874	amod	first,15
R3108	T3876	T3872	pobj	minutes,during
R3109	T3877	T3876	prep	following,minutes
R311	T464	T465	compound	ganglion,death
R3110	T3878	T3877	pobj	injection,following
R3111	T3879	T3861	cc	but,had
R3112	T3880	T3881	det	a,effect
R3113	T3881	T3861	conj	effect,had
R3114	T3882	T3881	amod	strong,effect
R3115	T3883	T3881	amod	hypotensive,effect
R3116	T3884	T3881	prep	between,effect
R3117	T3885	T3886	nummod	15,minutes
R3118	T3886	T3884	pobj	minutes,between
R3119	T3887	T3885	cc	and,15
R312	T465	T462	dobj	death,involves
R3120	T3888	T3885	conj	30,15
R3121	T3889	T3890	dep	that,continued
R3122	T3890	T3881	relcl	continued,effect
R3123	T3891	T3890	prep	for,continued
R3124	T3892	T3893	amod	more,an
R3125	T3893	T3895	nummod	an,hour
R3126	T3894	T3893	quantmod	than,an
R3127	T3895	T3891	pobj	hour,for
R3128	T3896	T3897	punct	[,35
R3129	T3897	T3881	parataxis	35,effect
R313	T466	T465	compound	cell,death
R3130	T3898	T3897	punct	],35
R3131	T3899	T3861	punct	.,had
R3132	T3901	T3902	prep	In,shown
R3133	T3903	T3901	pobj	contrast,In
R3134	T3904	T3902	punct	", ",shown
R3135	T3905	T3906	advmod	intraperitoneally,administered
R3136	T3906	T3907	amod	administered,ketamine
R3137	T3907	T3902	nsubjpass	ketamine,shown
R3138	T3908	T3909	punct	(,mg
R3139	T3909	T3907	parataxis	mg,ketamine
R314	T467	T465	cc	and,death
R3140	T3910	T3909	nummod	100,mg
R3141	T3911	T3912	punct	/,kg
R3142	T3912	T3909	prep	kg,mg
R3143	T3913	T3909	punct	),mg
R3144	T3914	T3902	auxpass	was,shown
R3145	T3915	T3916	aux	to,decrease
R3146	T3916	T3902	xcomp	decrease,shown
R3147	T3917	T3916	advmod	rapidly,decrease
R3148	T3918	T3916	dobj	IOP,decrease
R3149	T3919	T3916	prep	in,decrease
R315	T468	T469	amod	optic,damage
R3150	T3920	T3921	det	a,study
R3151	T3921	T3919	pobj	study,in
R3152	T3922	T3921	amod	different,study
R3153	T3923	T3921	compound	rat,study
R3154	T3924	T3925	punct	[,36
R3155	T3925	T3902	parataxis	36,shown
R3156	T3926	T3925	punct	],36
R3157	T3927	T3902	punct	.,shown
R3158	T3929	T3930	nsubj	IOP,decreased
R3159	T3931	T3930	advmod	significantly,decreased
R316	T469	T465	conj	damage,death
R3160	T3932	T3930	prep	between,decreased
R3161	T3933	T3934	det	a,measurement
R3162	T3934	T3932	pobj	measurement,between
R3163	T3935	T3934	amod	conscious,measurement
R3164	T3936	T3934	cc	and,measurement
R3165	T3937	T3938	det	the,measurement
R3166	T3938	T3934	conj	measurement,measurement
R3167	T3939	T3938	amod	first,measurement
R3168	T3940	T3938	amod	possible,measurement
R3169	T3941	T3938	prep	under,measurement
R317	T470	T469	compound	nerve,damage
R3170	T3942	T3941	pobj	anesthesia,under
R3171	T3943	T3944	punct	(,defined
R3172	T3944	T3930	parataxis	defined,decreased
R3173	T3945	T3944	prep	as,defined
R3174	T3946	T3945	pobj	time,as
R3175	T3947	T3946	nummod	0,time
R3176	T3948	T3944	punct	),defined
R3177	T3949	T3930	punct	.,decreased
R3178	T3951	T3952	nsubj	IOP,decreased
R3179	T3953	T3952	advmod	further,decreased
R318	T471	T472	dep	that,associated
R3180	T3954	T3952	prep	by,decreased
R3181	T3955	T3956	det	the,reading
R3182	T3956	T3954	pobj	reading,by
R3183	T3957	T3956	amod	next,reading
R3184	T3958	T3956	punct	(,reading
R3185	T3959	T3956	prep	at,reading
R3186	T3960	T3961	nummod	5,minutes
R3187	T3961	T3959	pobj	minutes,at
R3188	T3962	T3956	punct	),reading
R3189	T3963	T3964	prep	after,remained
R319	T472	T469	relcl	associated,damage
R3190	T3964	T3956	relcl	remained,reading
R3191	T3965	T3963	pobj	which,after
R3192	T3966	T3964	nsubj	it,remained
R3193	T3967	T3964	acomp	stable,remained
R3194	T3968	T3964	prep	for,remained
R3195	T3969	T3970	det	the,duration
R3196	T3970	T3968	pobj	duration,for
R3197	T3971	T3970	prep	of,duration
R3198	T3972	T3973	det	the,experiment
R3199	T3973	T3971	pobj	experiment,of
R32	T68	T69	det	this,study
R320	T473	T472	auxpass	is,associated
R3200	T3974	T3970	punct	(,duration
R3201	T3975	T3976	nummod	20,minutes
R3202	T3976	T3970	appos	minutes,duration
R3203	T3977	T3952	punct	),decreased
R3204	T3978	T3979	punct	[,36
R3205	T3979	T3952	parataxis	36,decreased
R3206	T3980	T3979	punct	],36
R3207	T3981	T3952	punct	.,decreased
R3208	T3983	T3984	det	The,measurement
R3209	T3984	T3987	nsubj	measurement,was
R321	T474	T472	advmod	often,associated
R3210	T3985	T3984	nmod	time,measurement
R3211	T3986	T3985	nummod	0,time
R3212	T3988	T3984	prep	in,measurement
R3213	T3989	T3990	det	that,study
R3214	T3990	T3988	pobj	study,in
R3215	T3991	T3987	prep	at,was
R3216	T3992	T3993	det	a,state
R3217	T3993	T3991	pobj	state,at
R3218	T3994	T3995	advmod	very,similar
R3219	T3995	T3993	amod	similar,state
R322	T475	T472	prep	with,associated
R3220	T3996	T3993	prep	of,state
R3221	T3997	T3996	pobj	anesthesia,of
R3222	T3998	T3993	prep	as,state
R3223	T3999	T4000	poss	our,points
R3224	T4000	T3998	pobj	points,as
R3225	T4001	T4002	nummod	4,minute
R3226	T4002	T4000	nmod	minute,points
R3227	T4003	T4001	cc	and,4
R3228	T4004	T4001	conj	5,4
R3229	T4005	T4000	compound	time,points
R323	T476	T477	amod	elevated,pressure
R3230	T4006	T3987	punct	(,was
R3231	T4007	T3987	xcomp	starting,was
R3232	T4008	T4009	advmod	as,soon
R3233	T4009	T4010	advmod	soon,within
R3234	T4010	T4007	prep	within,starting
R3235	T4011	T4009	prep	as,soon
R3236	T4012	T4011	amod	possible,as
R3237	T4013	T4010	cc	and,within
R3238	T4014	T4015	quantmod	20,60
R3239	T4015	T4017	nummod	60,seconds
R324	T477	T475	pobj	pressure,with
R3240	T4016	T4015	quantmod	to,60
R3241	T4017	T4010	pobj	seconds,within
R3242	T4018	T4017	prep	of,seconds
R3243	T4019	T4020	amod	adequate,anesthesia
R3244	T4020	T4018	pobj	anesthesia,of
R3245	T4021	T3987	punct	),was
R3246	T4022	T3987	punct	", ",was
R3247	T4023	T3987	cc	and,was
R3248	T4024	T4025	det	the,point
R3249	T4025	T4030	nsubj	point,was
R325	T478	T477	amod	intraocular,pressure
R3250	T4026	T4027	nummod	5,minute
R3251	T4027	T4028	nmod	minute,rat
R3252	T4028	T4025	compound	rat,point
R3253	T4029	T4025	compound	time,point
R3254	T4030	T3987	conj	was,was
R3255	T4031	T4030	acomp	similar,was
R3256	T4032	T4031	prep	to,similar
R3257	T4033	T4034	poss	our,times
R3258	T4034	T4032	pobj	times,to
R3259	T4035	T4036	nummod	9,minute
R326	T479	T477	punct	(,pressure
R3260	T4036	T4034	nmod	minute,times
R3261	T4037	T4035	cc	and,9
R3262	T4038	T4035	conj	10,9
R3263	T4039	T4034	compound	measurement,times
R3264	T4040	T4030	punct	.,was
R3265	T4042	T4043	advmod	Thus,agree
R3266	T4044	T4043	punct	", ",agree
R3267	T4045	T4046	mark	although,show
R3268	T4046	T4043	advcl	show,agree
R3269	T4047	T4048	preconj	both,studies
R327	T480	T477	appos	IOP,pressure
R3270	T4048	T4046	nsubj	studies,show
R3271	T4049	T4048	nmod	rat,studies
R3272	T4050	T4049	cc	and,rat
R3273	T4051	T4049	conj	mouse,rat
R3274	T4052	T4053	mark	that,decreases
R3275	T4053	T4046	ccomp	decreases,show
R3276	T4054	T4053	nsubj	anesthesia,decreases
R3277	T4055	T4053	dobj	IOP,decreases
R3278	T4056	T4043	punct	", ",agree
R3279	T4057	T4058	det	the,studies
R328	T481	T462	punct	),involves
R3280	T4058	T4043	nsubj	studies,agree
R3281	T4059	T4043	aux	do,agree
R3282	T4060	T4043	neg	not,agree
R3283	T4061	T4043	prep	on,agree
R3284	T4062	T4063	det	the,timing
R3285	T4063	T4061	pobj	timing,on
R3286	T4064	T4063	prep	of,timing
R3287	T4065	T4066	det	the,effect
R3288	T4066	T4064	pobj	effect,of
R3289	T4067	T4043	punct	.,agree
R329	T482	T483	punct	[,1
R3290	T4069	T4070	det	The,depression
R3291	T4070	T4072	nsubj	depression,occurred
R3292	T4071	T4070	compound	IOP,depression
R3293	T4073	T4074	advmod	very,soon
R3294	T4074	T4075	advmod	soon,after
R3295	T4075	T4072	prep	after,occurred
R3296	T4076	T4075	pobj	anesthesia,after
R3297	T4077	T4072	prep	in,occurred
R3298	T4078	T4079	det	the,rats
R3299	T4079	T4077	pobj	rats,in
R33	T69	T67	pobj	study,of
R330	T483	T462	parataxis	1,involves
R3300	T4080	T4072	cc	but,occurred
R3301	T4081	T4082	auxpass	was,delayed
R3302	T4082	T4072	conj	delayed,occurred
R3303	T4083	T4082	prep	in,delayed
R3304	T4084	T4085	det	the,mice
R3305	T4085	T4083	pobj	mice,in
R3306	T4086	T4072	punct	.,occurred
R3307	T4158	T4159	nsubj	Environment,influence
R3308	T4160	T4159	aux	may,influence
R3309	T4161	T4162	det	the,effect
R331	T484	T485	punct	-,5
R3310	T4162	T4159	dobj	effect,influence
R3311	T4163	T4162	prep	of,effect
R3312	T4164	T4163	pobj	anesthesia,of
R3313	T4166	T4167	nsubj	Factors,include
R3314	T4168	T4169	dep	that,influence
R3315	T4169	T4166	relcl	influence,Factors
R3316	T4170	T4169	aux	may,influence
R3317	T4171	T4172	det	the,effect
R3318	T4172	T4169	dobj	effect,influence
R3319	T4173	T4172	prep	of,effect
R332	T485	T483	prep	5,1
R3320	T4174	T4173	pobj	anesthesia,of
R3321	T4175	T4176	det	the,species
R3322	T4176	T4167	dobj	species,include
R3323	T4177	T4176	punct	", ",species
R3324	T4178	T4176	conj	strain,species
R3325	T4179	T4178	cc	and,strain
R3326	T4180	T4178	conj	environment,strain
R3327	T4181	T4176	acl	used,species
R3328	T4182	T4167	punct	.,include
R3329	T4184	T4185	advmod	Essentially,dose
R333	T486	T483	punct	],1
R3330	T4185	T4188	nsubjpass	dose,used
R3331	T4186	T4185	det	the,dose
R3332	T4187	T4185	amod	same,dose
R3333	T4189	T4185	prep	of,dose
R3334	T4190	T4189	pobj	ketamine,of
R3335	T4191	T4185	cc	and,dose
R3336	T4192	T4185	conj	route,dose
R3337	T4193	T4192	prep	of,route
R3338	T4194	T4193	pobj	administration,of
R3339	T4195	T4188	auxpass	was,used
R334	T487	T462	punct	.,involves
R3340	T4196	T4188	prep	in,used
R3341	T4197	T4198	preconj	both,studies
R3342	T4198	T4196	pobj	studies,in
R3343	T4199	T4198	det	the,studies
R3344	T4200	T4201	nmod	rat,IOP
R3345	T4201	T4198	compound	IOP,studies
R3346	T4202	T4200	cc	and,rat
R3347	T4203	T4200	conj	mouse,rat
R3348	T4204	T4188	punct	.,used
R3349	T4206	T4207	prep	In,appear
R335	T489	T490	nsubj	It,becoming
R3350	T4208	T4206	pobj	mice,In
R3351	T4209	T4207	punct	", ",appear
R3352	T4210	T4211	det	the,strain
R3353	T4211	T4207	nsubj	strain,appear
R3354	T4212	T4207	aux	does,appear
R3355	T4213	T4207	neg	not,appear
R3356	T4214	T4215	aux	to,be
R3357	T4215	T4207	xcomp	be,appear
R3358	T4216	T4215	acomp	important,be
R3359	T4217	T4218	mark	as,was
R336	T491	T490	aux	is,becoming
R3360	T4218	T4207	advcl	was,appear
R3361	T4219	T4220	det	no,effect
R3362	T4220	T4218	nsubj	effect,was
R3363	T4221	T4220	amod	early,effect
R3364	T4222	T4220	prep	of,effect
R3365	T4223	T4222	pobj	anesthesia,of
R3366	T4224	T4218	acomp	present,was
R3367	T4225	T4218	prep	in,was
R3368	T4226	T4227	det	the,strains
R3369	T4227	T4225	pobj	strains,in
R337	T492	T493	advmod	increasingly,clear
R3370	T4228	T4227	nummod	three,strains
R3371	T4229	T4230	advmod	distantly,related
R3372	T4230	T4227	amod	related,strains
R3373	T4231	T4227	compound	laboratory,strains
R3374	T4232	T4233	punct	[,37
R3375	T4233	T4227	parataxis	37,strains
R3376	T4234	T4233	punct	],37
R3377	T4235	T4236	nsubj	we,studied
R3378	T4236	T4227	advcl	studied,strains
R3379	T4237	T4236	prep	in,studied
R338	T493	T490	acomp	clear,becoming
R3380	T4238	T4237	pobj	detail,in
R3381	T4239	T4218	punct	", ",was
R3382	T4240	T4218	cc	and,was
R3383	T4241	T4242	nsubj	we,observed
R3384	T4242	T4218	conj	observed,was
R3385	T4243	T4242	aux	have,observed
R3386	T4244	T4242	neg	not,observed
R3387	T4245	T4246	det	any,effect
R3388	T4246	T4242	dobj	effect,observed
R3389	T4247	T4246	amod	obvious,effect
R339	T494	T495	mark	that,have
R3390	T4248	T4242	prep	during,observed
R3391	T4249	T4250	det	this,period
R3392	T4250	T4248	pobj	period,during
R3393	T4251	T4242	prep	in,observed
R3394	T4252	T4253	det	any,strain
R3395	T4253	T4251	pobj	strain,in
R3396	T4254	T4253	amod	analyzed,strain
R3397	T4255	T4207	punct	.,appear
R3398	T4257	T4258	amod	Environmental,differences
R3399	T4258	T4259	nsubj	differences,be
R34	T70	T71	aux	to,determine
R340	T495	T490	ccomp	have,becoming
R3400	T4260	T4259	aux	may,be
R3401	T4261	T4259	acomp	important,be
R3402	T4262	T4259	punct	.,be
R3403	T4264	T4265	compound	Cage,cleanliness
R3404	T4265	T4266	nsubj	cleanliness,alter
R3405	T4267	T4265	punct	", ",cleanliness
R3406	T4268	T4269	compound	changing,frequency
R3407	T4269	T4265	conj	frequency,cleanliness
R3408	T4270	T4269	cc	and,frequency
R3409	T4271	T4272	compound	housing,density
R341	T496	T497	amod	many,forms
R3410	T4272	T4269	conj	density,frequency
R3411	T4273	T4266	aux	can,alter
R3412	T4274	T4275	compound	drug,metabolism
R3413	T4275	T4266	dobj	metabolism,alter
R3414	T4276	T4275	cc	and,metabolism
R3415	T4277	T4278	det	the,effect
R3416	T4278	T4275	conj	effect,metabolism
R3417	T4279	T4278	prep	of,effect
R3418	T4280	T4279	pobj	anesthesia,of
R3419	T4281	T4266	prep	in,alter
R342	T497	T495	nsubj	forms,have
R3420	T4282	T4281	pobj	rats,in
R3421	T4283	T4284	punct	[,39
R3422	T4284	T4266	parataxis	39,alter
R3423	T4285	T4284	nummod	38,39
R3424	T4286	T4284	punct	",",39
R3425	T4287	T4284	punct	],39
R3426	T4288	T4266	punct	.,alter
R3427	T4290	T4291	det	The,type
R3428	T4291	T4292	nsubj	type,be
R3429	T4293	T4291	prep	of,type
R343	T498	T497	prep	of,forms
R3430	T4294	T4293	pobj	bedding,of
R3431	T4295	T4291	acl	used,type
R3432	T4296	T4292	advmod	also,be
R3433	T4297	T4292	aux	may,be
R3434	T4298	T4292	acomp	important,be
R3435	T4299	T4292	punct	.,be
R3436	T4301	T4302	nsubj	We,use
R3437	T4303	T4304	compound	wood,shavings
R3438	T4304	T4302	dobj	shavings,use
R3439	T4305	T4302	prep	for,use
R344	T499	T498	pobj	glaucoma,of
R3440	T4306	T4305	pobj	bedding,for
R3441	T4307	T4302	cc	and,use
R3442	T4308	T4309	compound	wood,shavings
R3443	T4309	T4310	nsubj	shavings,expose
R3444	T4310	T4302	conj	expose,use
R3445	T4311	T4312	det	the,mice
R3446	T4312	T4310	dobj	mice,expose
R3447	T4313	T4310	prep	to,expose
R3448	T4314	T4313	pobj	terpenes,to
R3449	T4315	T4310	punct	.,expose
R345	T500	T501	det	a,component
R3450	T4317	T4318	compound	Terpene,administration
R3451	T4318	T4319	nsubj	administration,alters
R3452	T4320	T4318	cc	or,administration
R3453	T4321	T4322	amod	environmental,exposure
R3454	T4322	T4318	conj	exposure,administration
R3455	T4323	T4322	prep	to,exposure
R3456	T4324	T4323	pobj	terpenes,to
R3457	T4325	T4324	prep	in,terpenes
R3458	T4326	T4327	compound	wood,shavings
R3459	T4327	T4325	pobj	shavings,in
R346	T501	T495	dobj	component,have
R3460	T4328	T4329	compound	drug,resistance
R3461	T4329	T4319	dobj	resistance,alters
R3462	T4330	T4319	cc	and,alters
R3463	T4331	T4319	conj	decreases,alters
R3464	T4332	T4333	det	the,effect
R3465	T4333	T4331	dobj	effect,decreases
R3466	T4334	T4333	prep	of,effect
R3467	T4335	T4336	amod	anesthetic,agents
R3468	T4336	T4334	pobj	agents,of
R3469	T4337	T4319	prep	in,alters
R347	T502	T501	amod	genetic,component
R3470	T4338	T4339	preconj	both,rats
R3471	T4339	T4337	pobj	rats,in
R3472	T4340	T4339	cc	and,rats
R3473	T4341	T4339	conj	mice,rats
R3474	T4342	T4343	punct	[,40
R3475	T4343	T4319	parataxis	40,alters
R3476	T4344	T4345	punct	-,45
R3477	T4345	T4343	prep	45,40
R3478	T4346	T4343	punct	],40
R3479	T4347	T4319	punct	.,alters
R348	T503	T504	punct	[,7
R3480	T4408	T4409	compound	Risk,factors
R3481	T4410	T4409	prep	for,factors
R3482	T4411	T4412	amod	increased,IOP
R3483	T4412	T4410	pobj	IOP,for
R3484	T4414	T4415	det	Some,studies
R3485	T4415	T4417	nsubj	studies,implicate
R3486	T4416	T4415	amod	epidemiological,studies
R3487	T4418	T4417	dobj	factors,implicate
R3488	T4419	T4420	amod	such,as
R3489	T4420	T4418	prep	as,factors
R349	T504	T490	parataxis	7,becoming
R3490	T4421	T4420	pobj	diabetes,as
R3491	T4422	T4421	punct	", ",diabetes
R3492	T4423	T4424	amod	vascular,hypertension
R3493	T4424	T4421	conj	hypertension,diabetes
R3494	T4425	T4424	punct	", ",hypertension
R3495	T4426	T4427	amod	arterial,hypotension
R3496	T4427	T4424	conj	hypotension,hypertension
R3497	T4428	T4427	punct	", ",hypotension
R3498	T4429	T4427	conj	vasospasm,hypotension
R3499	T4430	T4429	punct	", ",vasospasm
R35	T71	T66	ccomp	determine,was
R350	T505	T504	nummod	6,7
R3500	T4431	T4432	amod	aberrant,autoregulation
R3501	T4432	T4429	conj	autoregulation,vasospasm
R3502	T4433	T4432	prep	of,autoregulation
R3503	T4434	T4435	compound	blood,flow
R3504	T4435	T4433	pobj	flow,of
R3505	T4436	T4432	cc	and,autoregulation
R3506	T4437	T4432	conj	sex,autoregulation
R3507	T4438	T4417	prep	in,implicate
R3508	T4439	T4438	pobj	glaucoma,in
R3509	T4440	T4417	punct	.,implicate
R351	T506	T504	punct	",",7
R3510	T4442	T4443	amod	Other,studies
R3511	T4443	T4444	nsubj	studies,find
R3512	T4445	T4446	det	no,association
R3513	T4446	T4444	dobj	association,find
R3514	T4447	T4446	prep	between,association
R3515	T4448	T4449	det	these,factors
R3516	T4449	T4447	pobj	factors,between
R3517	T4450	T4449	cc	and,factors
R3518	T4451	T4449	conj	glaucoma,factors
R3519	T4452	T4453	punct	[,46
R352	T507	T504	punct	],7
R3520	T4453	T4444	parataxis	46,find
R3521	T4454	T4453	dep	2,46
R3522	T4455	T4454	punct	",",2
R3523	T4456	T4457	punct	-,48
R3524	T4457	T4453	prep	48,46
R3525	T4458	T4453	punct	],46
R3526	T4459	T4444	punct	.,find
R3527	T4461	T4462	advmod	Similarly,associated
R3528	T4463	T4462	punct	", ",associated
R3529	T4464	T4465	det	the,effects
R353	T508	T490	punct	", ",becoming
R3530	T4465	T4462	nsubjpass	effects,associated
R3531	T4466	T4465	prep	of,effects
R3532	T4467	T4468	amod	various,factors
R3533	T4468	T4466	pobj	factors,of
R3534	T4469	T4468	prep	including,factors
R3535	T4470	T4469	pobj	age,including
R3536	T4471	T4470	punct	", ",age
R3537	T4472	T4470	conj	gender,age
R3538	T4473	T4472	punct	", ",gender
R3539	T4474	T4475	compound	blood,pressure
R354	T509	T490	cc	and,becoming
R3540	T4475	T4472	conj	pressure,gender
R3541	T4476	T4475	punct	", ",pressure
R3542	T4477	T4475	conj	obesity,pressure
R3543	T4478	T4477	cc	and,obesity
R3544	T4479	T4477	conj	diabetes,obesity
R3545	T4480	T4462	aux	have,associated
R3546	T4481	T4462	auxpass	been,associated
R3547	T4482	T4462	advmod	variably,associated
R3548	T4483	T4462	prep	with,associated
R3549	T4484	T4485	amod	elevated,IOP
R355	T510	T511	amod	much,research
R3550	T4485	T4483	pobj	IOP,with
R3551	T4486	T4462	punct	.,associated
R3552	T4488	T4489	nsubj	We,evaluated
R3553	T4490	T4491	det	the,relationship
R3554	T4491	T4489	dobj	relationship,evaluated
R3555	T4492	T4491	prep	between,relationship
R3556	T4493	T4494	det	these,factors
R3557	T4494	T4492	pobj	factors,between
R3558	T4495	T4494	amod	latter,factors
R3559	T4496	T4494	cc	and,factors
R356	T511	T513	nsubjpass	research,focused
R3560	T4497	T4494	conj	IOP,factors
R3561	T4498	T4489	prep	in,evaluated
R3562	T4499	T4500	advmod	genetically,homogeneous
R3563	T4500	T4501	amod	homogeneous,strains
R3564	T4501	T4498	pobj	strains,in
R3565	T4502	T4501	compound	mouse,strains
R3566	T4503	T4489	prep	in,evaluated
R3567	T4504	T4505	det	a,environment
R3568	T4505	T4503	pobj	environment,in
R3569	T4506	T4505	amod	controlled,environment
R357	T512	T511	amod	current,research
R3570	T4507	T4489	punct	.,evaluated
R3571	T4511	T4512	mark	Although,within
R3572	T4512	T4513	advcl	within,decreased
R3573	T4514	T4515	det	the,range
R3574	T4515	T4512	pobj	range,within
R3575	T4516	T4515	prep	of,range
R3576	T4517	T4516	pobj	variability,of
R3577	T4518	T4517	acl	observed,variability
R3578	T4519	T4518	prep	in,observed
R3579	T4520	T4521	amod	young,mice
R358	T513	T490	conj	focused,becoming
R3580	T4521	T4519	pobj	mice,in
R3581	T4522	T4513	punct	", ",decreased
R3582	T4523	T4524	det	the,IOP
R3583	T4524	T4513	nsubj	IOP,decreased
R3584	T4525	T4524	prep	of,IOP
R3585	T4526	T4527	compound	B6,mice
R3586	T4527	T4525	pobj	mice,of
R3587	T4528	T4513	advmod	modestly,decreased
R3588	T4529	T4530	quantmod	around,1
R3589	T4530	T4531	nummod	1,year
R359	T514	T513	auxpass	is,focused
R3590	T4531	T4513	npadvmod	year,decreased
R3591	T4532	T4531	prep	of,year
R3592	T4533	T4532	pobj	age,of
R3593	T4534	T4513	punct	.,decreased
R3594	T4536	T4537	det	This,decrease
R3595	T4537	T4538	nsubj	decrease,was
R3596	T4539	T4540	advmod	statistically,significant
R3597	T4540	T4538	acomp	significant,was
R3598	T4541	T4538	prep	compared,was
R3599	T4542	T4541	prep	to,compared
R36	T72	T73	det	the,IOPs
R360	T515	T513	prep	on,focused
R3600	T4543	T4544	amod	young,mice
R3601	T4544	T4542	pobj	mice,to
R3602	T4545	T4544	acl	measured,mice
R3603	T4546	T4545	prep	at,measured
R3604	T4547	T4548	det	the,time
R3605	T4548	T4546	pobj	time,at
R3606	T4549	T4548	amod	same,time
R3607	T4550	T4538	punct	.,was
R3608	T4552	T4553	prep	At,decreased
R3609	T4554	T4555	nummod	2,years
R361	T516	T515	pcomp	identifying,on
R3610	T4555	T4552	pobj	years,At
R3611	T4556	T4555	prep	of,years
R3612	T4557	T4556	pobj	age,of
R3613	T4558	T4559	det	the,IOP
R3614	T4559	T4553	nsubj	IOP,decreased
R3615	T4560	T4559	prep	of,IOP
R3616	T4561	T4562	compound	B6,mice
R3617	T4562	T4560	pobj	mice,of
R3618	T4563	T4553	aux	had,decreased
R3619	T4564	T4553	advmod	further,decreased
R362	T517	T518	amod	chromosomal,regions
R3620	T4565	T4553	punct	", ",decreased
R3621	T4566	T4567	mark	though,ruled
R3622	T4567	T4553	advcl	ruled,decreased
R3623	T4568	T4569	det	an,effect
R3624	T4569	T4567	nsubjpass	effect,ruled
R3625	T4570	T4569	prep	of,effect
R3626	T4571	T4570	pobj	anesthesia,of
R3627	T4572	T4569	prep	in,effect
R3628	T4573	T4574	det	these,mice
R3629	T4574	T4572	pobj	mice,in
R363	T518	T516	dobj	regions,identifying
R3630	T4575	T4576	advmod	very,old
R3631	T4576	T4574	amod	old,mice
R3632	T4577	T4567	aux	can,ruled
R3633	T4578	T4567	neg	not,ruled
R3634	T4579	T4567	auxpass	be,ruled
R3635	T4580	T4567	prt	out,ruled
R3636	T4581	T4582	punct	[,49
R3637	T4582	T4553	parataxis	49,decreased
R3638	T4583	T4582	punct	],49
R3639	T4584	T4553	punct	.,decreased
R364	T519	T518	cc	and,regions
R3640	T4586	T4587	det	The,IOP
R3641	T4587	T4588	nsubj	IOP,decreased
R3642	T4589	T4587	prep	of,IOP
R3643	T4590	T4591	compound	129P3,J
R3644	T4591	T4593	compound	J,mice
R3645	T4592	T4591	punct	/,J
R3646	T4593	T4589	pobj	mice,of
R3647	T4594	T4588	advmod	also,decreased
R3648	T4595	T4588	prep	with,decreased
R3649	T4596	T4595	pobj	age,with
R365	T520	T518	conj	genes,regions
R3650	T4597	T4595	cc	but,with
R3651	T4598	T4597	advmod	only,but
R3652	T4599	T4595	conj	at,with
R3653	T4600	T4601	det	the,age
R3654	T4601	T4599	pobj	age,at
R3655	T4602	T4601	amod	oldest,age
R3656	T4603	T4601	acl	examined,age
R3657	T4604	T4601	punct	(,age
R3658	T4605	T4606	nummod	18,months
R3659	T4606	T4601	appos	months,age
R366	T521	T522	dep	that,contribute
R3660	T4607	T4588	punct	),decreased
R3661	T4608	T4588	punct	.,decreased
R3662	T4610	T4611	amod	Decreasing,IOP
R3663	T4611	T4612	nsubj	IOP,correlates
R3664	T4613	T4612	prep	with,correlates
R3665	T4614	T4615	amod	increasing,age
R3666	T4615	T4613	pobj	age,with
R3667	T4616	T4615	prep	in,age
R3668	T4617	T4618	det	the,population
R3669	T4618	T4616	pobj	population,in
R367	T522	T518	relcl	contribute,regions
R3670	T4619	T4618	amod	human,population
R3671	T4620	T4618	amod	Japanese,population
R3672	T4621	T4622	punct	[,51
R3673	T4622	T4612	parataxis	51,correlates
R3674	T4623	T4622	nummod	50,51
R3675	T4624	T4622	punct	",",51
R3676	T4625	T4622	punct	],51
R3677	T4626	T4612	punct	.,correlates
R3678	T4628	T4629	amod	Further,studies
R3679	T4629	T4630	nsubj	studies,allow
R368	T523	T522	prep	to,contribute
R3680	T4631	T4629	prep	of,studies
R3681	T4632	T4633	compound	B6,mice
R3682	T4633	T4631	pobj	mice,of
R3683	T4634	T4630	aux	may,allow
R3684	T4635	T4636	amod	experimental,investigation
R3685	T4636	T4630	dobj	investigation,allow
R3686	T4637	T4636	prep	of,investigation
R3687	T4638	T4639	det	this,effect
R3688	T4639	T4637	pobj	effect,of
R3689	T4640	T4630	punct	.,allow
R369	T524	T523	pobj	glaucoma,to
R3690	T4642	T4643	amod	Additional,studies
R3691	T4643	T4644	nsubj	studies,identify
R3692	T4645	T4644	aux	may,identify
R3693	T4646	T4644	advmod	also,identify
R3694	T4647	T4644	punct	"""",identify
R3695	T4648	T4649	amod	normal,strains
R3696	T4649	T4644	dobj	strains,identify
R3697	T4650	T4649	punct	"""",strains
R3698	T4651	T4649	compound	mouse,strains
R3699	T4652	T4653	dep	that,develop
R37	T73	T71	dobj	IOPs,determine
R370	T525	T526	punct	[,8
R3700	T4653	T4649	relcl	develop,strains
R3701	T4654	T4655	amod	increased,IOP
R3702	T4655	T4653	dobj	IOP,develop
R3703	T4656	T4653	prep	with,develop
R3704	T4657	T4656	pobj	age,with
R3705	T4658	T4659	mark	as,occurs
R3706	T4659	T4644	advcl	occurs,identify
R3707	T4660	T4659	advmod	generally,occurs
R3708	T4661	T4659	prep	in,occurs
R3709	T4662	T4663	amod	Western,populations
R371	T526	T513	parataxis	8,focused
R3710	T4663	T4661	pobj	populations,in
R3711	T4664	T4665	punct	[,53
R3712	T4665	T4644	parataxis	53,identify
R3713	T4666	T4665	nummod	52,53
R3714	T4667	T4665	punct	",",53
R3715	T4668	T4665	punct	],53
R3716	T4669	T4644	punct	.,identify
R3717	T4671	T4672	nsubj	We,demonstrated
R3718	T4673	T4672	advmod	previously,demonstrated
R3719	T4674	T4675	mark	that,develop
R372	T527	T528	punct	-,10
R3720	T4675	T4672	ccomp	develop,demonstrated
R3721	T4676	T4677	det	the,2J
R3722	T4677	T4675	nsubj	2J,develop
R3723	T4678	T4677	amod	glaucomatous,2J
R3724	T4679	T4677	compound	strains,2J
R3725	T4680	T4677	compound	DBA,2J
R3726	T4681	T4677	punct	/,2J
R3727	T4682	T4677	cc	and,2J
R3728	T4683	T4684	compound	AKXD,Ty
R3729	T4684	T4677	conj	Ty,2J
R373	T528	T526	prep	10,8
R3730	T4685	T4684	punct	-,Ty
R3731	T4686	T4684	compound	28,Ty
R3732	T4687	T4684	punct	/,Ty
R3733	T4688	T4689	amod	elevated,IOP
R3734	T4689	T4675	dobj	IOP,develop
R3735	T4690	T4675	prep	with,develop
R3736	T4691	T4690	pobj	age,with
R3737	T4692	T4693	punct	[,19
R3738	T4693	T4675	parataxis	19,develop
R3739	T4694	T4693	nummod	14,19
R374	T529	T526	punct	],8
R3740	T4695	T4693	punct	",",19
R3741	T4696	T4693	punct	],19
R3742	T4697	T4672	punct	.,demonstrated
R3743	T4701	T4702	prep	In,found
R3744	T4703	T4704	det	the,strains
R3745	T4704	T4701	pobj	strains,In
R3746	T4705	T4704	amod	examined,strains
R3747	T4706	T4702	punct	", ",found
R3748	T4707	T4702	nsubj	we,found
R3749	T4708	T4709	det	no,differences
R375	T530	T513	punct	.,focused
R3750	T4709	T4702	dobj	differences,found
R3751	T4710	T4709	amod	consistent,differences
R3752	T4711	T4709	prep	in,differences
R3753	T4712	T4711	pobj	IOP,in
R3754	T4713	T4702	prep	between,found
R3755	T4714	T4713	pobj	males,between
R3756	T4715	T4714	cc	and,males
R3757	T4716	T4714	conj	females,males
R3758	T4717	T4702	punct	.,found
R3759	T4719	T4720	nsubj	This,was
R376	T532	T533	csubj	Identifying,allows
R3760	T4721	T4720	acomp	true,was
R3761	T4722	T4720	prep	at,was
R3762	T4723	T4724	det	all,ages
R3763	T4724	T4722	pobj	ages,at
R3764	T4725	T4720	prep	for,was
R3765	T4726	T4727	det	the,strains
R3766	T4727	T4725	pobj	strains,for
R3767	T4728	T4727	nummod	3,strains
R3768	T4729	T4730	dep	that,aged
R3769	T4730	T4727	relcl	aged,strains
R377	T534	T535	amod	such,loci
R3770	T4731	T4730	auxpass	were,aged
R3771	T4732	T4730	prep	to,aged
R3772	T4733	T4734	nummod	18,months
R3773	T4734	T4732	pobj	months,to
R3774	T4735	T4736	cc	or,older
R3775	T4736	T4734	nummod	older,months
R3776	T4737	T4720	punct	.,was
R3777	T4739	T4740	nsubj	This,is
R3778	T4741	T4740	prep	in,is
R3779	T4742	T4741	pobj	agreement,in
R378	T535	T532	dobj	loci,Identifying
R3780	T4743	T4742	prep	with,agreement
R3781	T4744	T4745	det	a,number
R3782	T4745	T4743	pobj	number,with
R3783	T4746	T4745	prep	of,number
R3784	T4747	T4748	amod	human,studies
R3785	T4748	T4746	pobj	studies,of
R3786	T4749	T4745	punct	", ",number
R3787	T4750	T4751	dep	which,show
R3788	T4751	T4745	relcl	show,number
R3789	T4752	T4753	mark	that,is
R379	T536	T533	xcomp	screening,allows
R3790	T4753	T4751	ccomp	is,show
R3791	T4754	T4753	nsubj	IOP,is
R3792	T4755	T4753	acomp	equal,is
R3793	T4756	T4753	prep	between,is
R3794	T4757	T4758	det	the,sexes
R3795	T4758	T4756	pobj	sexes,between
R3796	T4759	T4760	punct	[,53
R3797	T4760	T4740	parataxis	53,is
R3798	T4761	T4760	nummod	52,53
R3799	T4762	T4760	punct	",",53
R38	T74	T73	prep	of,IOPs
R380	T537	T536	prep	for,screening
R3800	T4763	T4760	punct	],53
R3801	T4764	T4740	punct	.,is
R3802	T4766	T4767	advmod	However,found
R3803	T4768	T4767	punct	", ",found
R3804	T4769	T4770	det	some,studies
R3805	T4770	T4767	nsubj	studies,found
R3806	T4771	T4767	aux	have,found
R3807	T4772	T4773	npadvmod	sex,specific
R3808	T4773	T4775	amod	specific,differences
R3809	T4774	T4773	punct	-,specific
R381	T538	T537	pobj	individuals,for
R3810	T4775	T4767	dobj	differences,found
R3811	T4776	T4775	punct	(,differences
R3812	T4777	T4778	advmod	typically,with
R3813	T4778	T4775	prep	with,differences
R3814	T4779	T4780	amod	higher,IOP
R3815	T4780	T4778	pobj	IOP,with
R3816	T4781	T4780	prep	in,IOP
R3817	T4782	T4781	pobj	females,in
R3818	T4783	T4780	cc	and,IOP
R3819	T4784	T4785	det	the,magnitude
R382	T539	T538	prep	with,individuals
R3820	T4785	T4786	nsubj	magnitude,increasing
R3821	T4786	T4780	conj	increasing,IOP
R3822	T4787	T4785	prep	of,magnitude
R3823	T4788	T4789	det	the,difference
R3824	T4789	T4787	pobj	difference,of
R3825	T4790	T4786	prep	after,increasing
R3826	T4791	T4792	nummod	40,years
R3827	T4792	T4790	pobj	years,after
R3828	T4793	T4792	prep	of,years
R3829	T4794	T4793	pobj	age,of
R383	T540	T541	det	an,risk
R3830	T4795	T4767	punct	),found
R3831	T4796	T4797	punct	[,54
R3832	T4797	T4767	parataxis	54,found
R3833	T4798	T4797	nummod	53,54
R3834	T4799	T4797	punct	",",54
R3835	T4800	T4797	punct	],54
R3836	T4801	T4767	punct	.,found
R3837	T4803	T4804	prep	Of,reported
R3838	T4805	T4806	amod	possible,relevance
R3839	T4806	T4803	pobj	relevance,Of
R384	T541	T539	pobj	risk,with
R3840	T4807	T4804	punct	", ",reported
R3841	T4808	T4804	nsubj	we,reported
R3842	T4809	T4804	advmod	previously,reported
R3843	T4810	T4811	mark	that,develop
R3844	T4811	T4804	ccomp	develop,reported
R3845	T4812	T4813	amod	female,mice
R3846	T4813	T4811	nsubj	mice,develop
R3847	T4814	T4813	prep	of,mice
R3848	T4815	T4816	compound	strains,2J
R3849	T4816	T4814	pobj	2J,of
R385	T542	T541	amod	increased,risk
R3850	T4817	T4816	compound	DBA,2J
R3851	T4818	T4816	punct	/,2J
R3852	T4819	T4816	cc	and,2J
R3853	T4820	T4821	compound	AKXD,Ty
R3854	T4821	T4816	conj	Ty,2J
R3855	T4822	T4821	punct	-,Ty
R3856	T4823	T4821	compound	28,Ty
R3857	T4824	T4821	punct	/,Ty
R3858	T4825	T4826	amod	elevated,IOP
R3859	T4826	T4811	dobj	IOP,develop
R386	T543	T541	prep	of,risk
R3860	T4827	T4811	prep	at,develop
R3861	T4828	T4829	det	an,age
R3862	T4829	T4827	pobj	age,at
R3863	T4830	T4829	amod	earlier,age
R3864	T4831	T4829	prep	than,age
R3865	T4832	T4831	pobj	males,than
R3866	T4833	T4834	punct	[,19
R3867	T4834	T4804	parataxis	19,reported
R3868	T4835	T4834	nummod	14,19
R3869	T4836	T4834	punct	",",19
R387	T544	T543	pcomp	developing,of
R3870	T4837	T4834	punct	],19
R3871	T4838	T4804	punct	.,reported
R3872	T4840	T4841	compound	Blood,pressure
R3873	T4843	T4844	nsubj	Some,reported
R3874	T4845	T4843	cc	but,Some
R3875	T4846	T4845	neg	not,but
R3876	T4847	T4848	nmod	all,studies
R3877	T4848	T4843	conj	studies,Some
R3878	T4849	T4848	amod	human,studies
R3879	T4850	T4844	aux	have,reported
R388	T545	T544	dobj	glaucoma,developing
R3880	T4851	T4852	det	a,association
R3881	T4852	T4844	dobj	association,reported
R3882	T4853	T4852	amod	positive,association
R3883	T4854	T4852	prep	between,association
R3884	T4855	T4854	pobj	IOP,between
R3885	T4856	T4855	cc	and,IOP
R3886	T4857	T4858	compound	blood,pressure
R3887	T4858	T4855	conj	pressure,IOP
R3888	T4859	T4860	punct	[,52
R3889	T4860	T4844	parataxis	52,reported
R389	T546	T547	punct	[,11
R3890	T4861	T4860	nummod	48,52
R3891	T4862	T4860	punct	",",52
R3892	T4863	T4860	punct	],52
R3893	T4864	T4844	punct	.,reported
R3894	T4866	T4867	poss	Our,comparison
R3895	T4867	T4868	nsubj	comparison,reveal
R3896	T4869	T4867	prep	of,comparison
R3897	T4870	T4871	det	the,relationship
R3898	T4871	T4869	pobj	relationship,of
R3899	T4872	T4871	prep	between,relationship
R39	T75	T76	advmod	genetically,distinct
R390	T547	T533	parataxis	11,allows
R3900	T4873	T4874	compound	blood,pressure
R3901	T4874	T4872	pobj	pressure,between
R3902	T4875	T4874	cc	and,pressure
R3903	T4876	T4874	conj	IOP,pressure
R3904	T4877	T4874	prep	in,pressure
R3905	T4878	T4879	amod	young,mice
R3906	T4879	T4877	pobj	mice,in
R3907	T4880	T4879	punct	", ",mice
R3908	T4881	T4879	amod	adult,mice
R3909	T4882	T4879	amod	female,mice
R391	T548	T547	punct	],11
R3910	T4883	T4879	prep	of,mice
R3911	T4884	T4885	amod	different,strains
R3912	T4885	T4883	pobj	strains,of
R3913	T4886	T4885	compound	mouse,strains
R3914	T4887	T4879	punct	", ",mice
R3915	T4888	T4889	poss	whose,pressures
R3916	T4889	T4891	dep	pressures,differed
R3917	T4890	T4889	compound	blood,pressures
R3918	T4891	T4879	relcl	differed,mice
R3919	T4892	T4893	advmod	up,36
R392	T549	T533	punct	.,allows
R3920	T4893	T4895	nummod	36,mmHg
R3921	T4894	T4893	quantmod	to,36
R3922	T4895	T4891	dobj	mmHg,differed
R3923	T4896	T4868	punct	", ",reveal
R3924	T4897	T4868	aux	did,reveal
R3925	T4898	T4868	neg	not,reveal
R3926	T4899	T4900	det	a,correlation
R3927	T4900	T4868	dobj	correlation,reveal
R3928	T4901	T4900	amod	positive,correlation
R3929	T4902	T4868	punct	.,reveal
R393	T551	T552	csubj	Identifying,is
R3930	T4904	T4905	amod	Further,studies
R3931	T4905	T4906	nsubjpass	studies,needed
R3932	T4907	T4906	auxpass	are,needed
R3933	T4908	T4909	aux	to,determine
R3934	T4909	T4906	advcl	determine,needed
R3935	T4910	T4911	mark	if,correlates
R3936	T4911	T4909	ccomp	correlates,determine
R3937	T4912	T4913	compound	blood,pressure
R3938	T4913	T4911	nsubj	pressure,correlates
R3939	T4914	T4911	prep	with,correlates
R394	T553	T551	dobj	genes,Identifying
R3940	T4915	T4914	pobj	IOP,with
R3941	T4916	T4911	prep	in,correlates
R3942	T4917	T4916	pobj	males,in
R3943	T4918	T4909	punct	", ",determine
R3944	T4919	T4909	cc	and,determine
R3945	T4920	T4921	aux	to,determine
R3946	T4921	T4909	conj	determine,determine
R3947	T4922	T4923	det	the,relationship
R3948	T4923	T4921	dobj	relationship,determine
R3949	T4924	T4923	prep	between,relationship
R395	T554	T553	acl	contributing,genes
R3950	T4925	T4926	compound	blood,pressure
R3951	T4926	T4924	pobj	pressure,between
R3952	T4927	T4926	cc	and,pressure
R3953	T4928	T4926	conj	IOP,pressure
R3954	T4929	T4923	prep	in,relationship
R3955	T4930	T4931	amod	various,strains
R3956	T4931	T4929	pobj	strains,in
R3957	T4932	T4931	compound	mouse,strains
R3958	T4933	T4923	prep	with,relationship
R3959	T4934	T4933	pobj	age,with
R396	T555	T554	prep	to,contributing
R3960	T4935	T4906	punct	.,needed
R3961	T4938	T4937	cc	and,Obesity
R3962	T4939	T4937	conj	diabetes,Obesity
R3963	T4941	T4942	nsubjpass	Obesity,implicated
R3964	T4943	T4941	cc	or,Obesity
R3965	T4944	T4945	amod	higher,index
R3966	T4945	T4941	conj	index,Obesity
R3967	T4946	T4947	compound	body,mass
R3968	T4947	T4945	compound	mass,index
R3969	T4948	T4942	aux	have,implicated
R397	T556	T557	amod	elevated,IOP
R3970	T4949	T4942	auxpass	been,implicated
R3971	T4950	T4942	agent	by,implicated
R3972	T4951	T4952	det	some,studies
R3973	T4952	T4950	pobj	studies,by
R3974	T4953	T4952	cc	but,studies
R3975	T4954	T4953	neg	not,but
R3976	T4955	T4952	amod	other,studies
R3977	T4956	T4942	prep	as,implicated
R3978	T4957	T4958	compound	risk,factors
R3979	T4958	T4956	pobj	factors,as
R398	T557	T555	pobj	IOP,to
R3980	T4959	T4958	prep	for,factors
R3981	T4960	T4961	amod	increased,IOP
R3982	T4961	T4959	pobj	IOP,for
R3983	T4962	T4961	cc	and,IOP
R3984	T4963	T4961	conj	glaucoma,IOP
R3985	T4964	T4965	punct	[,57
R3986	T4965	T4942	parataxis	57,implicated
R3987	T4966	T4965	nummod	51,57
R3988	T4967	T4965	punct	",",57
R3989	T4968	T4965	nummod	55,57
R399	T558	T557	cc	and,IOP
R3990	T4969	T4965	punct	-,57
R3991	T4970	T4965	punct	],57
R3992	T4971	T4942	punct	.,implicated
R3993	T4973	T4974	advmod	Similarly,associated
R3994	T4975	T4974	punct	", ",associated
R3995	T4976	T4974	nsubjpass	diabetes,associated
R3996	T4977	T4976	cc	or,diabetes
R3997	T4978	T4979	det	the,combination
R3998	T4979	T4976	conj	combination,diabetes
R3999	T4980	T4979	prep	of,combination
R4	T33	T34	advmod	genetically,distinct
R40	T76	T77	amod	distinct,strains
R400	T559	T557	conj	glaucoma,IOP
R4000	T4981	T4980	pobj	diabetes,of
R4001	T4982	T4981	cc	and,diabetes
R4002	T4983	T4981	conj	obesity,diabetes
R4003	T4984	T4974	aux	have,associated
R4004	T4985	T4974	auxpass	been,associated
R4005	T4986	T4974	advmod	variably,associated
R4006	T4987	T4974	prep	with,associated
R4007	T4988	T4989	amod	elevated,IOP
R4008	T4989	T4987	pobj	IOP,with
R4009	T4990	T4989	cc	and,IOP
R401	T560	T561	advmod	only,step
R4010	T4991	T4989	conj	glaucoma,IOP
R4011	T4992	T4993	punct	[,46
R4012	T4993	T4974	parataxis	46,associated
R4013	T4994	T4993	punct	",",46
R4014	T4995	T4993	appos	52,46
R4015	T4996	T4993	punct	",",46
R4016	T4997	T4993	appos	58,46
R4017	T4998	T4999	punct	-,62
R4018	T4999	T4997	prep	62,58
R4019	T5000	T4993	punct	],46
R402	T561	T552	attr	step,is
R4020	T5001	T4974	punct	.,associated
R4021	T5003	T5004	aux	To,test
R4022	T5004	T5005	advcl	test,compared
R4023	T5006	T5007	mark	if,alter
R4024	T5007	T5004	ccomp	alter,test
R4025	T5008	T5009	amod	genetic,perturbations
R4026	T5009	T5007	nsubj	perturbations,alter
R4027	T5010	T5011	dep	that,cause
R4028	T5011	T5009	relcl	cause,perturbations
R4029	T5012	T5011	dobj	obesity,cause
R403	T562	T561	det	the,step
R4030	T5013	T5012	cc	and,obesity
R4031	T5014	T5012	conj	diabetes,obesity
R4032	T5015	T5007	aux	can,alter
R4033	T5016	T5007	dobj	IOP,alter
R4034	T5017	T5005	punct	", ",compared
R4035	T5018	T5005	nsubj	we,compared
R4036	T5019	T5005	dobj	groups,compared
R4037	T5020	T5019	prep	of,groups
R4038	T5021	T5020	pobj	mice,of
R4039	T5022	T5023	dep	that,were
R404	T563	T561	amod	first,step
R4040	T5023	T5019	relcl	were,groups
R4041	T5024	T5025	advmod	genetically,similar
R4042	T5025	T5023	acomp	similar,were
R4043	T5026	T5023	prep	except,were
R4044	T5027	T5028	mark	that,were
R4045	T5028	T5026	pcomp	were,except
R4046	T5029	T5028	nsubj	they,were
R4047	T5030	T5031	preconj	either,homozygous
R4048	T5031	T5028	acomp	homozygous,were
R4049	T5032	T5031	cc	or,homozygous
R405	T564	T552	punct	", ",is
R4050	T5033	T5031	conj	heterozygous,homozygous
R4051	T5034	T5033	prep	for,heterozygous
R4052	T5035	T5036	det	a,mutation
R4053	T5036	T5034	pobj	mutation,for
R4054	T5037	T5036	compound	leptin,mutation
R4055	T5038	T5036	compound	receptor,mutation
R4056	T5039	T5036	punct	(,mutation
R4057	T5040	T5036	appos	db,mutation
R4058	T5041	T5036	punct	),mutation
R4059	T5042	T5043	dep	that,results
R406	T565	T552	advmod	however,is
R4060	T5043	T5036	relcl	results,mutation
R4061	T5044	T5043	prep	in,results
R4062	T5045	T5046	amod	early,onset
R4063	T5046	T5044	pobj	onset,in
R4064	T5047	T5046	appos	obesity,onset
R4065	T5048	T5047	cc	and,obesity
R4066	T5049	T5047	conj	diabetes,obesity
R4067	T5050	T5005	punct	.,compared
R4068	T5052	T5053	det	The,mice
R4069	T5053	T5057	nsubj	mice,had
R407	T566	T552	punct	", ",is
R4070	T5054	T5053	amod	obese,mice
R4071	T5055	T5053	punct	", ",mice
R4072	T5056	T5053	amod	diabetic,mice
R4073	T5058	T5059	amod	higher,IOPs
R4074	T5059	T5057	dobj	IOPs,had
R4075	T5060	T5059	prep	than,IOPs
R4076	T5061	T5062	poss	their,littermates
R4077	T5062	T5060	pobj	littermates,than
R4078	T5063	T5062	amod	lean,littermates
R4079	T5064	T5062	punct	", ",littermates
R408	T567	T552	cc	and,is
R4080	T5065	T5062	amod	non-diabetic,littermates
R4081	T5066	T5057	punct	.,had
R4082	T5068	T5069	advmod	Thus,supported
R4083	T5070	T5069	punct	", ",supported
R4084	T5071	T5072	amod	epidemiological,associations
R4085	T5072	T5069	nsubjpass	associations,supported
R4086	T5073	T5072	prep	between,associations
R4087	T5074	T5075	amod	increased,IOP
R4088	T5075	T5073	pobj	IOP,between
R4089	T5076	T5075	cc	and,IOP
R409	T568	T569	compound	animal,models
R4090	T5077	T5075	conj	obesity,IOP
R4091	T5078	T5077	cc	or,obesity
R4092	T5079	T5077	conj	diabetes,obesity
R4093	T5080	T5069	auxpass	are,supported
R4094	T5081	T5069	prep	by,supported
R4095	T5082	T5083	det	this,work
R4096	T5083	T5081	pobj	work,by
R4097	T5084	T5069	cc	and,supported
R4098	T5085	T5069	conj	appear,supported
R4099	T5086	T5087	aux	to,be
R41	T77	T74	pobj	strains,of
R410	T569	T570	nsubj	models,provide
R4100	T5087	T5085	xcomp	be,appear
R4101	T5088	T5089	advmod	functionally,relevant
R4102	T5089	T5087	acomp	relevant,be
R4103	T5090	T5069	punct	.,supported
R4104	T5092	T5093	amod	Further,experiments
R4105	T5093	T5094	nsubj	experiments,help
R4106	T5095	T5093	prep	with,experiments
R4107	T5096	T5097	amod	obese,non-diabetic
R4108	T5097	T5098	amod	non-diabetic,mice
R4109	T5098	T5095	pobj	mice,with
R411	T570	T552	conj	provide,is
R4110	T5099	T5097	cc	or,non-diabetic
R4111	T5100	T5101	amod	diabetic,non-obese
R4112	T5101	T5097	conj	non-obese,non-diabetic
R4113	T5102	T5094	aux	will,help
R4114	T5103	T5104	aux	to,characterize
R4115	T5104	T5094	xcomp	characterize,help
R4116	T5105	T5106	det	the,effects
R4117	T5106	T5104	dobj	effects,characterize
R4118	T5107	T5106	amod	separate,effects
R4119	T5108	T5106	prep	of,effects
R412	T571	T570	aux	will,provide
R4120	T5109	T5110	det	these,factors
R4121	T5110	T5108	pobj	factors,of
R4122	T5111	T5110	compound	risk,factors
R4123	T5112	T5094	punct	.,help
R4124	T5222	T5223	nsubjpass	IOP,increased
R4125	T5224	T5223	auxpass	is,increased
R4126	T5225	T5223	prep	during,increased
R4127	T5226	T5227	det	the,period
R4128	T5227	T5225	pobj	period,during
R4129	T5228	T5227	amod	dark,period
R413	T572	T570	dobj	systems,provide
R4130	T5229	T5227	prep	of,period
R4131	T5230	T5231	det	the,day
R4132	T5231	T5229	pobj	day,of
R4133	T5233	T5234	amod	Diurnal,variation
R4134	T5234	T5235	nsubj	variation,is
R4135	T5236	T5234	prep	in,variation
R4136	T5237	T5236	pobj	IOP,in
R4137	T5238	T5235	acomp	common,is
R4138	T5239	T5235	prep	in,is
R4139	T5240	T5239	pobj	humans,in
R414	T573	T572	prep	for,systems
R4140	T5241	T5240	cc	and,humans
R4141	T5242	T5243	compound	laboratory,animals
R4142	T5243	T5240	conj	animals,humans
R4143	T5244	T5245	punct	[,53
R4144	T5245	T5235	parataxis	53,is
R4145	T5246	T5245	punct	],53
R4146	T5247	T5235	punct	.,is
R4147	T5249	T5250	det	The,mechanisms
R4148	T5250	T5252	nsubjpass	mechanisms,defined
R4149	T5251	T5250	amod	molecular,mechanisms
R415	T574	T575	amod	subsequent,testing
R4150	T5253	T5250	acl	underlying,mechanisms
R4151	T5254	T5255	det	the,rhythm
R4152	T5255	T5253	dobj	rhythm,underlying
R4153	T5256	T5255	amod	diurnal,rhythm
R4154	T5257	T5252	auxpass	are,defined
R4155	T5258	T5252	neg	not,defined
R4156	T5259	T5252	cc	but,defined
R4157	T5260	T5261	amod	increased,humor
R4158	T5261	T5263	nsubj	humor,occurs
R4159	T5262	T5261	amod	aqueous,humor
R416	T575	T573	pobj	testing,for
R4160	T5263	T5252	conj	occurs,defined
R4161	T5264	T5261	appos	production,humor
R4162	T5265	T5264	cc	or,production
R4163	T5266	T5264	conj	flow,production
R4164	T5267	T5263	prep	during,occurs
R4165	T5268	T5269	det	the,period
R4166	T5269	T5267	pobj	period,during
R4167	T5270	T5269	prep	of,period
R4168	T5271	T5272	amod	increased,IOP
R4169	T5272	T5270	pobj	IOP,of
R417	T576	T575	compound	hypothesis,testing
R4170	T5273	T5263	prep	in,occurs
R4171	T5274	T5275	preconj	both,rabbits
R4172	T5275	T5273	pobj	rabbits,in
R4173	T5276	T5275	cc	and,rabbits
R4174	T5277	T5275	conj	humans,rabbits
R4175	T5278	T5279	punct	[,63
R4176	T5279	T5263	parataxis	63,occurs
R4177	T5280	T5281	punct	-,65
R4178	T5281	T5279	prep	65,63
R4179	T5282	T5279	punct	],63
R418	T577	T575	cc	and,testing
R4180	T5283	T5263	punct	.,occurs
R4181	T5285	T5286	amod	Small,changes
R4182	T5286	T5287	nsubj	changes,contribute
R4183	T5288	T5286	prep	in,changes
R4184	T5289	T5290	det	the,resistance
R4185	T5290	T5288	pobj	resistance,in
R4186	T5291	T5290	prep	to,resistance
R4187	T5292	T5293	amod	aqueous,drainage
R4188	T5293	T5291	pobj	drainage,to
R4189	T5294	T5293	compound	humor,drainage
R419	T578	T579	amod	experimental,dissection
R4190	T5295	T5287	aux	may,contribute
R4191	T5296	T5287	advmod	also,contribute
R4192	T5297	T5287	prep	to,contribute
R4193	T5298	T5299	amod	diurnal,differences
R4194	T5299	T5297	pobj	differences,to
R4195	T5300	T5299	prep	in,differences
R4196	T5301	T5300	pobj	IOP,in
R4197	T5302	T5303	punct	[,67
R4198	T5303	T5287	parataxis	67,contribute
R4199	T5304	T5303	nummod	66,67
R42	T78	T77	compound	mouse,strains
R420	T579	T575	conj	dissection,testing
R4200	T5305	T5303	punct	",",67
R4201	T5306	T5303	punct	],67
R4202	T5307	T5287	punct	.,contribute
R4203	T5309	T5310	nsubj	We,suspected
R4204	T5311	T5310	advmod	first,suspected
R4205	T5312	T5313	nsubj	IOP,changes
R4206	T5313	T5310	advcl	changes,suspected
R4207	T5314	T5313	prep	with,changes
R4208	T5315	T5314	pobj	time,with
R4209	T5316	T5315	prep	of,time
R421	T580	T579	prep	of,dissection
R4210	T5317	T5316	pobj	day,of
R4211	T5318	T5319	advmod	when,appeared
R4212	T5319	T5310	advcl	appeared,suspected
R4213	T5320	T5321	det	the,IOP
R4214	T5321	T5319	nsubj	IOP,appeared
R4215	T5322	T5321	prep	of,IOP
R4216	T5323	T5324	det	a,group
R4217	T5324	T5322	pobj	group,of
R4218	T5325	T5324	prep	of,group
R4219	T5326	T5327	compound	B6,mice
R422	T581	T580	pobj	pathogenesis,of
R4220	T5327	T5325	pobj	mice,of
R4221	T5328	T5321	acl	measured,IOP
R4222	T5329	T5328	prep	in,measured
R4223	T5330	T5331	det	the,hour
R4224	T5331	T5329	pobj	hour,in
R4225	T5332	T5333	amod	prior,to
R4226	T5333	T5331	prep	to,hour
R4227	T5334	T5333	pobj	onset,to
R4228	T5335	T5334	prep	of,onset
R4229	T5336	T5337	det	the,period
R423	T582	T570	punct	.,provide
R4230	T5337	T5335	pobj	period,of
R4231	T5338	T5337	amod	dark,period
R4232	T5339	T5340	aux	to,be
R4233	T5340	T5319	xcomp	be,appeared
R4234	T5341	T5340	acomp	higher,be
R4235	T5342	T5341	prep	than,higher
R4236	T5343	T5342	prep	at,than
R4237	T5344	T5345	amod	other,times
R4238	T5345	T5343	pobj	times,at
R4239	T5346	T5345	prep	of,times
R424	T584	T585	prep	Due,are
R4240	T5347	T5346	pobj	day,of
R4241	T5348	T5310	punct	.,suspected
R4242	T5350	T5351	advmod	Previously,reported
R4243	T5352	T5351	punct	", ",reported
R4244	T5353	T5354	det	a,rise
R4245	T5354	T5351	nsubjpass	rise,reported
R4246	T5355	T5354	prep	of,rise
R4247	T5356	T5355	pobj	IOP,of
R4248	T5357	T5351	auxpass	was,reported
R4249	T5358	T5359	aux	to,occur
R425	T586	T584	pcomp	to,Due
R4250	T5359	T5351	xcomp	occur,reported
R4251	T5360	T5359	prep	before,occur
R4252	T5361	T5360	pobj	onset,before
R4253	T5362	T5361	prep	of,onset
R4254	T5363	T5364	det	the,period
R4255	T5364	T5362	pobj	period,of
R4256	T5365	T5364	amod	dark,period
R4257	T5366	T5359	prep	in,occur
R4258	T5367	T5366	pobj	rats,in
R4259	T5368	T5369	punct	[,21
R426	T587	T584	pobj	conservation,Due
R4260	T5369	T5359	parataxis	21,occur
R4261	T5370	T5369	punct	],21
R4262	T5371	T5351	punct	", ",reported
R4263	T5372	T5351	cc	and,reported
R4264	T5373	T5374	nsubjpass	rats,shown
R4265	T5374	T5351	conj	shown,reported
R4266	T5375	T5373	cc	and,rats
R4267	T5376	T5373	conj	rabbits,rats
R4268	T5377	T5374	auxpass	were,shown
R4269	T5378	T5379	aux	to,have
R427	T588	T587	prep	in,conservation
R4270	T5379	T5374	xcomp	have,shown
R4271	T5380	T5381	amod	higher,IOP
R4272	T5381	T5379	dobj	IOP,have
R4273	T5382	T5379	prep	during,have
R4274	T5383	T5384	det	the,period
R4275	T5384	T5382	pobj	period,during
R4276	T5385	T5384	amod	dark,period
R4277	T5386	T5379	prep	compared,have
R4278	T5387	T5386	prep	to,compared
R4279	T5388	T5389	det	the,period
R428	T589	T590	amod	mammalian,physiology
R4280	T5389	T5387	pobj	period,to
R4281	T5390	T5389	amod	light,period
R4282	T5391	T5392	punct	[,69
R4283	T5392	T5351	parataxis	69,reported
R4284	T5393	T5392	nummod	21,69
R4285	T5394	T5392	punct	",",69
R4286	T5395	T5392	nummod	68,69
R4287	T5396	T5392	punct	",",69
R4288	T5397	T5392	punct	],69
R4289	T5398	T5351	punct	.,reported
R429	T590	T588	pobj	physiology,in
R4290	T5400	T5401	advmod	Thus,compared
R4291	T5402	T5401	punct	", ",compared
R4292	T5403	T5401	nsubj	we,compared
R4293	T5404	T5405	det	the,IOPs
R4294	T5405	T5401	dobj	IOPs,compared
R4295	T5406	T5405	prep	of,IOPs
R4296	T5407	T5406	pobj	mice,of
R4297	T5408	T5401	prep	at,compared
R4298	T5409	T5410	amod	different,times
R4299	T5410	T5408	pobj	times,at
R43	T79	T71	punct	", ",determine
R430	T591	T587	cc	and,conservation
R4300	T5411	T5410	prep	of,times
R4301	T5412	T5411	pobj	day,of
R4302	T5413	T5401	cc	and,compared
R4303	T5414	T5401	conj	identified,compared
R4304	T5415	T5416	amod	several,strains
R4305	T5416	T5414	dobj	strains,identified
R4306	T5417	T5416	prep	with,strains
R4307	T5418	T5419	advmod	significantly,IOP
R4308	T5419	T5417	pobj	IOP,with
R4309	T5420	T5419	amod	higher,IOP
R431	T592	T593	det	the,tools
R4310	T5421	T5419	prep	during,IOP
R4311	T5422	T5423	det	the,dark
R4312	T5423	T5421	pobj	dark,during
R4313	T5424	T5423	prep	compared,dark
R4314	T5425	T5424	prep	to,compared
R4315	T5426	T5427	det	the,light
R4316	T5427	T5425	pobj	light,to
R4317	T5428	T5423	appos	period,dark
R4318	T5429	T5401	punct	.,compared
R4319	T5431	T5432	det	The,magnitude
R432	T593	T587	conj	tools,conservation
R4320	T5432	T5433	nsubj	magnitude,varies
R4321	T5434	T5432	prep	of,magnitude
R4322	T5435	T5436	det	the,difference
R4323	T5436	T5434	pobj	difference,of
R4324	T5437	T5433	prep	with,varies
R4325	T5438	T5437	pobj	strain,with
R4326	T5439	T5433	punct	", ",varies
R4327	T5440	T5433	cc	and,varies
R4328	T5441	T5433	conj	was,varies
R4329	T5442	T5441	acomp	greatest,was
R433	T594	T593	amod	powerful,tools
R4330	T5443	T5441	prep	in,was
R4331	T5444	T5445	compound	SWR,J
R4332	T5445	T5443	pobj	J,in
R4333	T5446	T5445	punct	/,J
R4334	T5447	T5433	punct	.,varies
R4335	T5449	T5450	det	The,increase
R4336	T5450	T5452	nsubj	increase,is
R4337	T5451	T5450	compound	IOP,increase
R4338	T5453	T5450	prep	in,increase
R4339	T5454	T5455	det	the,dark
R434	T595	T593	prep	of,tools
R4340	T5455	T5453	pobj	dark,in
R4341	T5456	T5452	neg	not,is
R4342	T5457	T5452	acomp	dependent,is
R4343	T5458	T5457	prep	on,dependent
R4344	T5459	T5460	amod	functional,photoreceptors
R4345	T5460	T5458	pobj	photoreceptors,on
R4346	T5461	T5460	nmod	rod,photoreceptors
R4347	T5462	T5461	cc	and,rod
R4348	T5463	T5461	conj	cone,rod
R4349	T5464	T5465	mark	since,degenerate
R435	T596	T597	compound	mouse,genetics
R4350	T5465	T5452	advcl	degenerate,is
R4351	T5466	T5467	det	these,cells
R4352	T5467	T5465	nsubj	cells,degenerate
R4353	T5468	T5465	prep	in,degenerate
R4354	T5469	T5470	compound	SWR,J
R4355	T5470	T5472	compound	J,mice
R4356	T5471	T5470	punct	/,J
R4357	T5472	T5468	pobj	mice,in
R4358	T5473	T5465	prep	due,degenerate
R4359	T5474	T5473	pcomp	to,due
R436	T597	T595	pobj	genetics,of
R4360	T5475	T5473	pobj	homozygosity,due
R4361	T5476	T5475	prep	for,homozygosity
R4362	T5477	T5478	det	the,mutation
R4363	T5478	T5476	pobj	mutation,for
R4364	T5479	T5478	compound	Pde6brd1,mutation
R4365	T5480	T5452	punct	.,is
R4366	T5482	T5483	prep	In,reported
R4367	T5484	T5482	pobj	agreement,In
R4368	T5485	T5484	prep	with,agreement
R4369	T5486	T5487	det	this,finding
R437	T598	T585	punct	", ",are
R4370	T5487	T5485	pobj	finding,with
R4371	T5488	T5483	punct	", ",reported
R4372	T5489	T5490	amod	circadian,regulation
R4373	T5490	T5483	nsubjpass	regulation,reported
R4374	T5491	T5490	prep	of,regulation
R4375	T5492	T5493	compound	wheel,running
R4376	T5493	T5491	pobj	running,of
R4377	T5494	T5493	prep	by,running
R4378	T5495	T5494	pobj	light,by
R4379	T5496	T5483	auxpass	was,reported
R438	T599	T585	nsubj	mice,are
R4380	T5497	T5483	advmod	previously,reported
R4381	T5498	T5483	prep	in,reported
R4382	T5499	T5498	pobj	mice,in
R4383	T5500	T5499	acl	lacking,mice
R4384	T5501	T5500	dobj	rods,lacking
R4385	T5502	T5501	cc	and,rods
R4386	T5503	T5501	conj	cones,rods
R4387	T5504	T5505	punct	[,70
R4388	T5505	T5483	parataxis	70,reported
R4389	T5506	T5505	punct	],70
R439	T600	T601	det	a,system
R4390	T5507	T5483	punct	.,reported
R4391	T5509	T5510	advmod	Interestingly,appear
R4392	T5511	T5510	punct	", ",appear
R4393	T5512	T5513	det	the,IOP
R4394	T5513	T5510	nsubj	IOP,appear
R4395	T5514	T5513	prep	of,IOP
R4396	T5515	T5516	compound	strain,CaJ
R4397	T5516	T5514	pobj	CaJ,of
R4398	T5517	T5516	compound	CBA,CaJ
R4399	T5518	T5516	punct	/,CaJ
R44	T80	T71	dep	assess,determine
R440	T601	T585	attr	system,are
R4400	T5519	T5513	punct	", ",IOP
R4401	T5520	T5521	dep	which,has
R4402	T5521	T5513	relcl	has,IOP
R4403	T5522	T5521	dobj	one,has
R4404	T5523	T5522	prep	of,one
R4405	T5524	T5525	det	the,IOPs
R4406	T5525	T5523	pobj	IOPs,of
R4407	T5526	T5525	amod	highest,IOPs
R4408	T5527	T5525	compound	daytime,IOPs
R4409	T5528	T5510	aux	does,appear
R441	T602	T603	advmod	very,important
R4410	T5529	T5510	neg	not,appear
R4411	T5530	T5531	aux	to,increase
R4412	T5531	T5510	xcomp	increase,appear
R4413	T5532	T5531	prep	in,increase
R4414	T5533	T5534	det	the,dark
R4415	T5534	T5532	pobj	dark,in
R4416	T5535	T5510	punct	.,appear
R4417	T5537	T5538	advmod	Further,needed
R4418	T5539	T5540	advmod	more,studies
R4419	T5540	T5538	nsubjpass	studies,needed
R442	T603	T601	amod	important,system
R4420	T5541	T5540	amod	detailed,studies
R4421	T5542	T5538	auxpass	are,needed
R4422	T5543	T5544	aux	to,define
R4423	T5544	T5538	advcl	define,needed
R4424	T5545	T5546	det	the,characteristics
R4425	T5546	T5544	dobj	characteristics,define
R4426	T5547	T5546	prep	of,characteristics
R4427	T5548	T5549	det	the,rhythm
R4428	T5549	T5547	pobj	rhythm,of
R4429	T5550	T5549	amod	diurnal,rhythm
R443	T604	T601	amod	experimental,system
R4430	T5551	T5549	prep	of,rhythm
R4431	T5552	T5553	amod	intraocular,pressure
R4432	T5553	T5551	pobj	pressure,of
R4433	T5554	T5549	prep	in,rhythm
R4434	T5555	T5554	pobj	mice,in
R4435	T5556	T5544	punct	", ",define
R4436	T5557	T5544	cc	and,define
R4437	T5558	T5559	aux	to,determine
R4438	T5559	T5544	conj	determine,define
R4439	T5560	T5561	mark	whether,is
R444	T605	T601	prep	for,system
R4440	T5561	T5559	ccomp	is,determine
R4441	T5562	T5561	nsubj	it,is
R4442	T5563	T5561	acomp	lacking,is
R4443	T5564	T5561	cc	or,is
R4444	T5565	T5561	conj	has,is
R4445	T5566	T5567	det	a,timing
R4446	T5567	T5565	dobj	timing,has
R4447	T5568	T5567	amod	different,timing
R4448	T5569	T5565	prep	in,has
R4449	T5570	T5571	compound	strain,CaJ
R445	T606	T605	pcomp	probing,for
R4450	T5571	T5569	pobj	CaJ,in
R4451	T5572	T5571	compound	CBA,CaJ
R4452	T5573	T5571	punct	/,CaJ
R4453	T5574	T5538	punct	.,needed
R4454	T5576	T5577	nsubj	Analysis,increase
R4455	T5578	T5576	prep	of,Analysis
R4456	T5579	T5580	det	these,strains
R4457	T5580	T5578	pobj	strains,of
R4458	T5581	T5580	compound	mouse,strains
R4459	T5582	T5577	aux	may,increase
R446	T607	T608	det	the,functions
R4460	T5583	T5577	dobj	understanding,increase
R4461	T5584	T5583	prep	of,understanding
R4462	T5585	T5586	det	the,mechanisms
R4463	T5586	T5584	pobj	mechanisms,of
R4464	T5587	T5586	amod	molecular,mechanisms
R4465	T5588	T5586	acl	controlling,mechanisms
R4466	T5589	T5590	amod	diurnal,rhythms
R4467	T5590	T5588	dobj	rhythms,controlling
R4468	T5591	T5590	prep	of,rhythms
R4469	T5592	T5591	pobj	IOP,of
R447	T608	T606	dobj	functions,probing
R4470	T5593	T5577	cc	and,increase
R4471	T5594	T5595	nsubj	that,be
R4472	T5595	T5577	conj	be,increase
R4473	T5596	T5595	aux	may,be
R4474	T5597	T5595	acomp	relevant,be
R4475	T5598	T5597	prep	to,relevant
R4476	T5599	T5598	pobj	glaucoma,to
R4477	T5600	T5595	punct	.,be
R448	T609	T608	punct	(,functions
R4480	T5691	T5692	compound	Car2,deficiency
R4481	T5692	T5693	nsubj	deficiency,alter
R4482	T5694	T5693	aux	does,alter
R4483	T5695	T5693	neg	not,alter
R4484	T5696	T5693	dobj	IOP,alter
R4485	T5698	T5699	compound	Bicarbonate,formation
R4486	T5699	T5700	nsubj	formation,is
R4487	T5701	T5700	acomp	important,is
R4488	T5702	T5701	prep	for,important
R4489	T5703	T5704	amod	aqueous,secretion
R449	T610	T611	preconj	both,in
R4490	T5704	T5702	pobj	secretion,for
R4491	T5705	T5704	compound	humor,secretion
R4492	T5706	T5704	prep	from,secretion
R4493	T5707	T5708	det	the,processes
R4494	T5708	T5706	pobj	processes,from
R4495	T5709	T5708	amod	ciliary,processes
R4496	T5710	T5700	cc	and,is
R4497	T5711	T5712	amod	carbonic,anhydrase
R4498	T5712	T5713	nsubj	anhydrase,facilitates
R4499	T5713	T5700	conj	facilitates,is
R45	T81	T82	det	the,effects
R450	T611	T608	prep	in,functions
R4500	T5714	T5712	punct	(,anhydrase
R4501	T5715	T5712	appos	CA,anhydrase
R4502	T5716	T5713	punct	),facilitates
R4503	T5717	T5718	det	this,secretion
R4504	T5718	T5713	dobj	secretion,facilitates
R4505	T5719	T5713	punct	.,facilitates
R4506	T5721	T5722	expl	There,are
R4507	T5723	T5724	amod	multiple,forms
R4508	T5724	T5722	attr	forms,are
R4509	T5725	T5724	prep	of,forms
R451	T612	T611	pobj	health,in
R4510	T5726	T5725	pobj	CA,of
R4511	T5727	T5722	cc	and,are
R4512	T5728	T5729	det	the,isoform
R4513	T5729	T5731	nsubjpass	isoform,reported
R4514	T5730	T5729	compound	CAII,isoform
R4515	T5731	T5722	conj	reported,are
R4516	T5732	T5731	auxpass	is,reported
R4517	T5733	T5734	aux	to,be
R4518	T5734	T5731	xcomp	be,reported
R4519	T5735	T5736	det	the,form
R452	T613	T612	cc	and,health
R4520	T5736	T5734	attr	form,be
R4521	T5737	T5736	amod	predominant,form
R4522	T5738	T5736	prep	in,form
R4523	T5739	T5740	det	the,processes
R4524	T5740	T5738	pobj	processes,in
R4525	T5741	T5740	amod	ciliary,processes
R4526	T5742	T5743	punct	[,72
R4527	T5743	T5731	parataxis	72,reported
R4528	T5744	T5743	nummod	71,72
R4529	T5745	T5743	punct	",",72
R453	T614	T612	conj	disease,health
R4530	T5746	T5743	punct	],72
R4531	T5747	T5731	punct	.,reported
R4532	T5749	T5750	poss	Our,experiments
R4533	T5750	T5751	nsubj	experiments,show
R4534	T5752	T5753	mark	that,alter
R4535	T5753	T5751	ccomp	alter,show
R4536	T5754	T5755	det	a,deficiency
R4537	T5755	T5753	nsubj	deficiency,alter
R4538	T5756	T5755	amod	genetic,deficiency
R4539	T5757	T5755	prep	of,deficiency
R454	T615	T608	punct	),functions
R4540	T5758	T5757	pobj	CAII,of
R4541	T5759	T5755	prep	in,deficiency
R4542	T5760	T5759	pobj	mice,in
R4543	T5761	T5760	amod	homozygous,mice
R4544	T5762	T5761	prep	for,homozygous
R4545	T5763	T5764	det	a,mutation
R4546	T5764	T5762	pobj	mutation,for
R4547	T5765	T5764	prep	in,mutation
R4548	T5766	T5767	det	the,gene
R4549	T5767	T5765	pobj	gene,in
R455	T616	T608	prep	of,functions
R4550	T5768	T5767	compound	Car2,gene
R4551	T5769	T5753	aux	does,alter
R4552	T5770	T5753	neg	not,alter
R4553	T5771	T5753	dobj	IOP,alter
R4554	T5772	T5751	punct	.,show
R4555	T5774	T5775	compound	CAIV,activity
R4556	T5775	T5776	nsubjpass	activity,demonstrated
R4557	T5777	T5776	auxpass	was,demonstrated
R4558	T5778	T5776	advmod	recently,demonstrated
R4559	T5779	T5776	prep	in,demonstrated
R456	T617	T618	amod	many,genes
R4560	T5780	T5781	det	the,processes
R4561	T5781	T5779	pobj	processes,in
R4562	T5782	T5781	amod	ciliary,processes
R4563	T5783	T5784	punct	[,73
R4564	T5784	T5776	parataxis	73,demonstrated
R4565	T5785	T5784	punct	],73
R4566	T5786	T5776	cc	and,demonstrated
R4567	T5787	T5786	advmod	so,and
R4568	T5788	T5789	poss	our,data
R4569	T5789	T5790	nsubj	data,support
R457	T618	T616	pobj	genes,of
R4570	T5790	T5776	conj	support,demonstrated
R4571	T5791	T5790	aux	may,support
R4572	T5792	T5793	det	a,role
R4573	T5793	T5790	dobj	role,support
R4574	T5794	T5793	advmod	more,role
R4575	T5795	T5793	amod	substantial,role
R4576	T5796	T5793	prep	for,role
R4577	T5797	T5796	pobj	CAIV,for
R4578	T5798	T5793	prep	compared,role
R4579	T5799	T5798	prep	to,compared
R458	T619	T620	advmod	recently,identified
R4580	T5800	T5799	pobj	CAII,to
R4581	T5801	T5793	prep	in,role
R4582	T5802	T5803	amod	aqueous,secretion
R4583	T5803	T5801	pobj	secretion,in
R4584	T5804	T5803	compound	humor,secretion
R4585	T5805	T5790	punct	.,support
R4586	T5807	T5808	nsubj	It,is
R4587	T5809	T5808	advmod	also,is
R4588	T5810	T5808	acomp	possible,is
R4589	T5811	T5812	mark	that,contributes
R459	T620	T618	acl	identified,genes
R4590	T5812	T5808	advcl	contributes,is
R4591	T5813	T5812	nsubj	CAII,contributes
R4592	T5814	T5812	advmod	substantially,contributes
R4593	T5815	T5812	prep	to,contributes
R4594	T5816	T5817	amod	aqueous,humor
R4595	T5817	T5818	compound	humor,secretion
R4596	T5818	T5815	pobj	secretion,to
R4597	T5819	T5812	cc	but,contributes
R4598	T5820	T5821	mark	that,is
R4599	T5821	T5812	conj	is,contributes
R46	T82	T80	dobj	effects,assess
R460	T621	T620	prep	by,identified
R4600	T5822	T5823	amod	functional,CAIV
R4601	T5823	T5821	nsubj	CAIV,is
R4602	T5824	T5823	compound	mouse,CAIV
R4603	T5825	T5821	acomp	sufficient,is
R4604	T5826	T5827	aux	to,prevent
R4605	T5827	T5825	xcomp	prevent,sufficient
R4606	T5828	T5829	det	an,effect
R4607	T5829	T5827	dobj	effect,prevent
R4608	T5830	T5829	prep	of,effect
R4609	T5831	T5832	compound	CAII,deficiency
R461	T622	T621	pcomp	sequencing,by
R4610	T5832	T5830	pobj	deficiency,of
R4611	T5833	T5829	prep	on,effect
R4612	T5834	T5833	pobj	IOP,on
R4613	T5835	T5834	prep	in,IOP
R4614	T5836	T5837	nmod	Car2,mice
R4615	T5837	T5835	pobj	mice,in
R4616	T5838	T5837	amod	mutant,mice
R4617	T5839	T5808	punct	.,is
R4618	T5841	T5842	prep	In,required
R4619	T5843	T5841	pobj	support,In
R462	T623	T624	det	the,genome
R4620	T5844	T5843	prep	of,support
R4621	T5845	T5846	det	a,role
R4622	T5846	T5844	pobj	role,of
R4623	T5847	T5846	prep	for,role
R4624	T5848	T5849	det	both,enzymes
R4625	T5849	T5847	pobj	enzymes,for
R4626	T5850	T5842	punct	", ",required
R4627	T5851	T5852	det	a,inhibition
R4628	T5852	T5842	nsubjpass	inhibition,required
R4629	T5853	T5854	amod	greater,90
R463	T624	T622	dobj	genome,sequencing
R4630	T5854	T5856	nummod	90,%
R4631	T5855	T5854	quantmod	than,90
R4632	T5856	T5852	compound	%,inhibition
R4633	T5857	T5852	prep	of,inhibition
R4634	T5858	T5857	pobj	CA,of
R4635	T5859	T5842	auxpass	is,required
R4636	T5860	T5842	prep	for,required
R4637	T5861	T5862	amod	significant,reduction
R4638	T5862	T5860	pobj	reduction,for
R4639	T5863	T5862	prep	of,reduction
R464	T625	T624	amod	human,genome
R4640	T5864	T5865	amod	aqueous,secretion
R4641	T5865	T5863	pobj	secretion,of
R4642	T5866	T5867	punct	[,72
R4643	T5867	T5842	parataxis	72,required
R4644	T5868	T5867	nummod	71,72
R4645	T5869	T5867	punct	",",72
R4646	T5870	T5867	punct	],72
R4647	T5871	T5842	punct	.,required
R4648	T5957	T5958	compound	Tyrosinase,deficiency
R4649	T5958	T5959	nsubj	deficiency,results
R465	T626	T627	punct	[,12
R4650	T5960	T5959	prep	in,results
R4651	T5961	T5962	amod	increased,IOP
R4652	T5962	T5960	pobj	IOP,in
R4653	T5964	T5965	nsubj	Tyrosinase,is
R4654	T5966	T5967	det	the,enzyme
R4655	T5967	T5965	attr	enzyme,is
R4656	T5968	T5967	amod	first,enzyme
R4657	T5969	T5967	prep	of,enzyme
R4658	T5970	T5971	det	the,pathway
R4659	T5971	T5969	pobj	pathway,of
R466	T627	T585	parataxis	12,are
R4660	T5972	T5973	compound	pigment,production
R4661	T5973	T5971	compound	production,pathway
R4662	T5974	T5965	punct	.,is
R4663	T5976	T5977	compound	Tyrosinase,deficiency
R4664	T5977	T5978	nsubj	deficiency,causes
R4665	T5979	T5978	dobj	albinism,causes
R4666	T5980	T5978	cc	and,causes
R4667	T5981	T5978	conj	has,causes
R4668	T5982	T5983	amod	various,consequences
R4669	T5983	T5981	dobj	consequences,has
R467	T628	T627	punct	],12
R4670	T5984	T5983	amod	ocular,consequences
R4671	T5985	T5978	punct	.,causes
R4672	T5987	T5988	nsubj	These,include
R4673	T5989	T5988	dobj	alteration,include
R4674	T5990	T5989	prep	of,alteration
R4675	T5991	T5992	det	the,number
R4676	T5992	T5990	pobj	number,of
R4677	T5993	T5992	prep	of,number
R4678	T5994	T5995	advmod	ipsilaterally,projecting
R4679	T5995	T5996	amod	projecting,axons
R468	T629	T585	punct	.,are
R4680	T5996	T5993	pobj	axons,of
R4681	T5997	T5996	amod	retinal,axons
R4682	T5998	T5989	cc	and,alteration
R4683	T5999	T6000	advmod	substantially,increased
R4684	T6000	T6001	amod	increased,penetration
R4685	T6001	T5989	conj	penetration,alteration
R4686	T6002	T6001	amod	light,penetration
R4687	T6003	T6001	prep	past,penetration
R4688	T6004	T6005	det	the,iris
R4689	T6005	T6003	pobj	iris,past
R469	T631	T632	nsubj	We,focused
R4690	T6006	T6007	punct	[,74
R4691	T6007	T5988	parataxis	74,include
R4692	T6008	T6007	punct	],74
R4693	T6009	T5988	punct	.,include
R4694	T6011	T6012	nsubjpass	It,known
R4695	T6013	T6012	auxpass	is,known
R4696	T6014	T6012	neg	not,known
R4697	T6015	T6016	mark	if,affect
R4698	T6016	T6012	ccomp	affect,known
R4699	T6017	T6018	det	these,abnormalities
R47	T83	T82	prep	of,effects
R470	T633	T632	aux	have,focused
R4700	T6018	T6016	nsubj	abnormalities,affect
R4701	T6019	T6020	amod	mammalian,IOP
R4702	T6020	T6016	dobj	IOP,affect
R4703	T6021	T6012	punct	.,known
R4704	T6023	T6024	advmod	Here,show
R4705	T6025	T6024	punct	", ",show
R4706	T6026	T6024	nsubj	we,show
R4707	T6027	T6028	amod	increased,IOP
R4708	T6028	T6024	dobj	IOP,show
R4709	T6029	T6028	prep	in,IOP
R471	T634	T632	prep	on,focused
R4710	T6030	T6029	pobj	mice,in
R4711	T6031	T6030	acl	lacking,mice
R4712	T6032	T6033	compound	tyrosinase,activity
R4713	T6033	T6031	dobj	activity,lacking
R4714	T6034	T6024	prep	compared,show
R4715	T6035	T6034	prep	to,compared
R4716	T6036	T6037	advmod	otherwise,identical
R4717	T6037	T6039	amod	identical,mice
R4718	T6038	T6037	advmod	genetically,identical
R4719	T6039	T6035	pobj	mice,to
R472	T635	T634	pcomp	developing,on
R4720	T6040	T6039	amod	pigmented,mice
R4721	T6041	T6039	compound	B6,mice
R4722	T6042	T6024	punct	.,show
R4723	T6044	T6045	advmod	Additionally,detected
R4724	T6046	T6045	punct	", ",detected
R4725	T6047	T6048	compound	IOP,differences
R4726	T6048	T6045	nsubjpass	differences,detected
R4727	T6049	T6048	prep	between,differences
R4728	T6050	T6051	det	the,period
R4729	T6051	T6049	pobj	period,between
R473	T636	T637	det	the,system
R4730	T6052	T6053	npadvmod	light,dark
R4731	T6053	T6051	amod	dark,period
R4732	T6054	T6053	cc	and,dark
R4733	T6055	T6051	prep	of,period
R4734	T6056	T6057	det	the,day
R4735	T6057	T6055	pobj	day,of
R4736	T6058	T6045	auxpass	were,detected
R4737	T6059	T6045	prep	in,detected
R4738	T6060	T6061	det	the,pigmented
R4739	T6061	T6059	pobj	pigmented,in
R474	T637	T635	dobj	system,developing
R4740	T6062	T6061	cc	but,pigmented
R4741	T6063	T6062	neg	not,but
R4742	T6064	T6065	det	the,albino
R4743	T6065	T6066	compound	albino,mice
R4744	T6066	T6061	conj	mice,pigmented
R4745	T6067	T6066	compound	B6,mice
R4746	T6068	T6045	punct	.,detected
R4747	T6070	T6071	advmod	Thus,affect
R4748	T6072	T6071	punct	", ",affect
R4749	T6073	T6071	nsubj	albinism,affect
R475	T638	T637	compound	mouse,system
R4750	T6074	T6071	aux	can,affect
R4751	T6075	T6076	det	the,pattern
R4752	T6076	T6071	dobj	pattern,affect
R4753	T6077	T6076	amod	diurnal,pattern
R4754	T6078	T6076	prep	of,pattern
R4755	T6079	T6080	compound	IOP,changes
R4756	T6080	T6078	pobj	changes,of
R4757	T6081	T6071	punct	.,affect
R4758	T6083	T6084	prep	In,have
R4759	T6085	T6083	pobj	agreement,In
R476	T639	T635	prep	for,developing
R4760	T6086	T6085	prep	with,agreement
R4761	T6087	T6088	det	this,result
R4762	T6088	T6086	pobj	result,with
R4763	T6089	T6084	punct	", ",have
R4764	T6090	T6084	nsubj	mice,have
R4765	T6091	T6090	prep	with,mice
R4766	T6092	T6093	compound	albino,eyes
R4767	T6093	T6091	pobj	eyes,with
R4768	T6094	T6095	dep	that,are
R4769	T6095	T6090	relcl	are,mice
R477	T640	T639	pobj	IOP,for
R4770	T6096	T6095	acomp	homozygous,are
R4771	T6097	T6096	prep	for,homozygous
R4772	T6098	T6097	pobj	tyrosinase,for
R4773	T6099	T6098	cc	or,tyrosinase
R4774	T6100	T6101	amod	pink,eye
R4775	T6101	T6102	compound	eye,mutations
R4776	T6102	T6098	conj	mutations,tyrosinase
R4777	T6103	T6102	compound	dilution,mutations
R4778	T6104	T6105	amod	altered,rhythms
R4779	T6105	T6084	dobj	rhythms,have
R478	T641	T640	cc	and,IOP
R4780	T6106	T6105	amod	diurnal,rhythms
R4781	T6107	T6084	prep	compared,have
R4782	T6108	T6107	prep	to,compared
R4783	T6109	T6110	amod	pigmented,mice
R4784	T6110	T6108	pobj	mice,to
R4785	T6111	T6112	punct	[,75
R4786	T6112	T6084	parataxis	75,have
R4787	T6113	T6112	punct	],75
R4788	T6114	T6084	punct	.,have
R4789	T6116	T6117	nsubj	Albinism,is
R479	T642	T643	compound	glaucoma,studies
R4790	T6118	T6116	prep	by,Albinism
R4791	T6119	T6118	pobj	itself,by
R4792	T6120	T6121	preconj	either,sufficient
R4793	T6121	T6117	acomp	sufficient,is
R4794	T6122	T6121	neg	not,sufficient
R4795	T6123	T6124	aux	to,alter
R4796	T6124	T6121	xcomp	alter,sufficient
R4797	T6125	T6126	det	the,rhythm
R4798	T6126	T6124	dobj	rhythm,alter
R4799	T6127	T6126	amod	diurnal,rhythm
R48	T84	T83	pobj	factors,of
R480	T643	T640	conj	studies,IOP
R4800	T6128	T6126	prep	of,rhythm
R4801	T6129	T6128	pobj	IOP,of
R4802	T6130	T6121	cc	or,sufficient
R4803	T6131	T6121	conj	alters,sufficient
R4804	T6132	T6131	dobj	it,alters
R4805	T6133	T6131	prep	in,alters
R4806	T6134	T6135	amod	different,ways
R4807	T6135	T6133	pobj	ways,in
R4808	T6136	T6131	prep	depending,alters
R4809	T6137	T6136	prep	upon,depending
R481	T644	T645	punct	[,13
R4810	T6138	T6139	amod	genetic,background
R4811	T6139	T6137	pobj	background,upon
R4812	T6140	T6131	punct	", ",alters
R4813	T6141	T6131	advmod	however,alters
R4814	T6142	T6131	punct	", ",alters
R4815	T6143	T6144	mark	since,had
R4816	T6144	T6131	advcl	had,alters
R4817	T6145	T6146	det	the,strains
R4818	T6146	T6144	nsubj	strains,had
R4819	T6147	T6146	compound	albino,strains
R482	T645	T632	parataxis	13,focused
R4820	T6148	T6149	compound	BALB,cByJ
R4821	T6149	T6146	appos	cByJ,strains
R4822	T6150	T6149	punct	/,cByJ
R4823	T6151	T6149	cc	and,cByJ
R4824	T6152	T6153	compound	SWR,J
R4825	T6153	T6149	conj	J,cByJ
R4826	T6154	T6153	punct	/,J
R4827	T6155	T6156	amod	increased,IOP
R4828	T6156	T6144	dobj	IOP,had
R4829	T6157	T6144	prep	during,had
R483	T646	T647	punct	-,19
R4830	T6158	T6159	det	the,dark
R4831	T6159	T6157	pobj	dark,during
R4832	T6160	T6117	punct	.,is
R4833	T6162	T6163	amod	Diurnal,rhythms
R4834	T6163	T6164	nsubjpass	rhythms,known
R4835	T6165	T6164	auxpass	are,known
R4836	T6166	T6167	aux	to,depend
R4837	T6167	T6164	xcomp	depend,known
R4838	T6168	T6167	prep	on,depend
R4839	T6169	T6170	amod	visual,pathways
R484	T647	T645	prep	19,13
R4840	T6170	T6168	pobj	pathways,on
R4841	T6171	T6167	cc	and,depend
R4842	T6172	T6173	aux	to,respond
R4843	T6173	T6167	conj	respond,depend
R4844	T6174	T6173	prep	to,respond
R4845	T6175	T6176	amod	light,intensity
R4846	T6176	T6174	pobj	intensity,to
R4847	T6177	T6164	punct	.,known
R4848	T6179	T6180	csubj	Exposing,abrogates
R4849	T6181	T6179	dobj	rats,Exposing
R485	T648	T645	punct	],13
R4850	T6182	T6179	prep	to,Exposing
R4851	T6183	T6184	nummod	24,hours
R4852	T6184	T6182	pobj	hours,to
R4853	T6185	T6184	prep	of,hours
R4854	T6186	T6187	amod	low,light
R4855	T6187	T6185	pobj	light,of
R4856	T6188	T6189	det	the,fluctuation
R4857	T6189	T6180	dobj	fluctuation,abrogates
R4858	T6190	T6189	amod	diurnal,fluctuation
R4859	T6191	T6189	prep	of,fluctuation
R486	T649	T632	punct	.,focused
R4860	T6192	T6191	pobj	IOP,of
R4861	T6193	T6180	cc	and,abrogates
R4862	T6194	T6180	conj	results,abrogates
R4863	T6195	T6194	prep	in,results
R4864	T6196	T6197	advmod	constantly,IOP
R4865	T6197	T6195	pobj	IOP,in
R4866	T6198	T6197	amod	elevated,IOP
R4867	T6199	T6200	punct	[,36
R4868	T6200	T6194	parataxis	36,results
R4869	T6201	T6200	punct	],36
R487	T651	T652	nsubjpass	Mice,expected
R4870	T6202	T6180	punct	.,abrogates
R4871	T6204	T6205	amod	Further,experiments
R4872	T6205	T6206	nsubj	experiments,determine
R4873	T6207	T6206	aux	will,determine
R4874	T6208	T6209	det	the,nature
R4875	T6209	T6206	dobj	nature,determine
R4876	T6210	T6209	prep	of,nature
R4877	T6211	T6212	det	the,rhythm
R4878	T6212	T6210	pobj	rhythm,of
R4879	T6213	T6212	amod	diurnal,rhythm
R488	T653	T652	auxpass	are,expected
R4880	T6214	T6212	prep	of,rhythm
R4881	T6215	T6214	pobj	IOP,of
R4882	T6216	T6212	prep	in,rhythm
R4883	T6217	T6218	det	the,mice
R4884	T6218	T6216	pobj	mice,in
R4885	T6219	T6218	compound	albino,mice
R4886	T6220	T6218	compound	B6,mice
R4887	T6221	T6209	cc	and,nature
R4888	T6222	T6223	mark	if,result
R4889	T6223	T6209	conj	result,nature
R489	T654	T655	aux	to,be
R4890	T6224	T6225	poss	its,alteration
R4891	T6225	T6223	nsubj	alteration,result
R4892	T6226	T6225	cc	or,alteration
R4893	T6227	T6228	amod	other,mechanisms
R4894	T6228	T6225	conj	mechanisms,alteration
R4895	T6229	T6223	prep	in,result
R4896	T6230	T6231	compound	IOP,elevation
R4897	T6231	T6229	pobj	elevation,in
R4898	T6232	T6206	punct	.,determine
R4899	T6299	T6314	prep	of,range
R49	T85	T86	amod	such,as
R490	T655	T652	xcomp	be,expected
R4900	T6300	T6301	amod	reproducible,differences
R4901	T6301	T6299	pobj	differences,of
R4902	T6302	T6301	compound	IOP,differences
R4903	T6303	T6316	prep	between,exists
R4904	T6304	T6305	amod	inbred,strains
R4905	T6305	T6303	pobj	strains,between
R4906	T6306	T6305	compound	mouse,strains
R4907	T6307	T6316	cc	and,exists
R4908	T6308	T6309	det	a,rhythm
R4909	T6309	T6311	nsubj	rhythm,exists
R491	T656	T657	advmod	extremely,helpful
R4910	T6310	T6309	amod	diurnal,rhythm
R4911	T6311	T6316	conj	exists,exists
R4912	T6312	T6309	prep	of,rhythm
R4913	T6313	T6314	det	A,range
R4914	T6314	T6316	nsubj	range,exists
R4915	T6315	T6314	amod	broad,range
R4916	T6317	T6312	pobj	IOP,of
R4917	T6318	T6311	prep	in,exists
R4918	T6319	T6320	amod	different,strains
R4919	T6320	T6318	pobj	strains,in
R492	T657	T655	acomp	helpful,be
R4920	T6321	T6311	punct	.,exists
R4921	T6323	T6324	amod	Various,factors
R4922	T6324	T6325	nsubjpass	factors,associated
R4923	T6326	T6325	aux	have,associated
R4924	T6327	T6325	auxpass	been,associated
R4925	T6328	T6325	advmod	variably,associated
R4926	T6329	T6325	prep	with,associated
R4927	T6330	T6329	pobj	risk,with
R4928	T6331	T6330	prep	for,risk
R4929	T6332	T6333	amod	increased,IOP
R493	T658	T657	prep	in,helpful
R4930	T6333	T6331	pobj	IOP,for
R4931	T6334	T6325	prep	in,associated
R4932	T6335	T6334	pobj	humans,in
R4933	T6336	T6325	punct	.,associated
R4934	T6338	T6339	advmod	Genetically,uniform
R4935	T6339	T6340	advcl	uniform,used
R4936	T6341	T6340	punct	", ",used
R4937	T6342	T6340	nsubjpass	mice,used
R4938	T6343	T6340	aux	can,used
R4939	T6344	T6340	auxpass	be,used
R494	T659	T658	pcomp	characterizing,in
R4940	T6345	T6346	aux	to,study
R4941	T6346	T6340	advcl	study,used
R4942	T6347	T6348	det	the,effects
R4943	T6348	T6346	dobj	effects,study
R4944	T6349	T6348	prep	of,effects
R4945	T6350	T6351	det	these,factors
R4946	T6351	T6349	pobj	factors,of
R4947	T6352	T6351	compound	risk,factors
R4948	T6353	T6348	prep	on,effects
R4949	T6354	T6353	pobj	IOP,on
R495	T660	T659	dobj	genes,characterizing
R4950	T6355	T6340	punct	.,used
R4951	T6357	T6358	prep	In,is
R4952	T6359	T6360	amod	trained,hands
R4953	T6360	T6357	pobj	hands,In
R4954	T6361	T6358	punct	", ",is
R4955	T6362	T6363	poss	our,procedure
R4956	T6363	T6358	nsubj	procedure,is
R4957	T6364	T6363	compound	measurement,procedure
R4958	T6365	T6366	amod	reliable,enough
R4959	T6366	T6358	acomp	enough,is
R496	T661	T660	cc	and,genes
R4960	T6367	T6365	punct	", ",reliable
R4961	T6368	T6365	conj	accurate,reliable
R4962	T6369	T6368	cc	and,accurate
R4963	T6370	T6368	conj	rapid,accurate
R4964	T6371	T6372	aux	to,allow
R4965	T6372	T6366	xcomp	allow,enough
R4966	T6373	T6374	amod	large,scale
R4967	T6374	T6375	nmod	scale,studies
R4968	T6375	T6372	dobj	studies,allow
R4969	T6376	T6375	amod	genetic,studies
R497	T662	T660	conj	mechanisms,genes
R4970	T6377	T6375	prep	of,studies
R4971	T6378	T6377	pobj	factors,of
R4972	T6379	T6378	acl	determining,factors
R4973	T6380	T6379	dobj	IOP,determining
R4974	T6381	T6358	punct	.,is
R4975	T6383	T6384	nsubj	Mice,have
R4976	T6385	T6386	amod	great,potential
R4977	T6386	T6384	dobj	potential,have
R4978	T6387	T6386	prep	for,potential
R4979	T6388	T6387	pcomp	helping,for
R498	T663	T664	dep	that,affect
R4980	T6389	T6390	aux	to,characterize
R4981	T6390	T6388	xcomp	characterize,helping
R4982	T6391	T6392	det	the,mechanisms
R4983	T6392	T6390	dobj	mechanisms,characterize
R4984	T6393	T6392	amod	molecular,mechanisms
R4985	T6394	T6392	acl	affecting,mechanisms
R4986	T6395	T6394	dobj	IOP,affecting
R4987	T6396	T6384	punct	.,have
R4988	T6430	T6431	compound	Animal,husbandry
R4989	T6433	T6434	det	All,experiments
R499	T664	T660	relcl	affect,genes
R4990	T6434	T6435	nsubjpass	experiments,performed
R4991	T6436	T6435	auxpass	were,performed
R4992	T6437	T6435	prep	in,performed
R4993	T6438	T6437	pobj	compliance,in
R4994	T6439	T6438	prep	with,compliance
R4995	T6440	T6441	det	the,statement
R4996	T6441	T6439	pobj	statement,with
R4997	T6442	T6441	compound	ARVO,statement
R4998	T6443	T6441	prep	for,statement
R4999	T6444	T6443	pobj	use,for
R5	T34	T35	amod	distinct,mice
R50	T86	T84	prep	as,factors
R500	T665	T664	dobj	IOP,affect
R5000	T6445	T6444	prep	of,use
R5001	T6446	T6445	pobj	animals,of
R5002	T6447	T6446	prep	in,animals
R5003	T6448	T6449	amod	ophthalmic,research
R5004	T6449	T6447	pobj	research,in
R5005	T6450	T6448	cc	and,ophthalmic
R5006	T6451	T6448	conj	vision,ophthalmic
R5007	T6452	T6435	punct	.,performed
R5008	T6454	T6455	det	All,mice
R5009	T6455	T6456	nsubjpass	mice,bred
R501	T666	T665	cc	or,IOP
R5010	T6457	T6456	auxpass	were,bred
R5011	T6458	T6456	cc	and,bred
R5012	T6459	T6456	conj	maintained,bred
R5013	T6460	T6459	prep	at,maintained
R5014	T6461	T6462	det	The,Laboratory
R5015	T6462	T6460	pobj	Laboratory,at
R5016	T6463	T6462	compound	Jackson,Laboratory
R5017	T6464	T6456	punct	.,bred
R5018	T6466	T6467	nsubjpass	Mice,housed
R5019	T6468	T6467	auxpass	were,housed
R502	T667	T668	det	the,susceptibility
R5020	T6469	T6467	prep	in,housed
R5021	T6470	T6469	pobj	cages,in
R5022	T6471	T6470	acl	containing,cages
R5023	T6472	T6473	amod	white,bedding
R5024	T6473	T6471	dobj	bedding,containing
R5025	T6474	T6473	compound	pine,bedding
R5026	T6475	T6471	cc	and,containing
R5027	T6476	T6471	conj	covered,containing
R5028	T6477	T6476	prep	with,covered
R5029	T6478	T6479	compound	polyester,filters
R503	T668	T665	conj	susceptibility,IOP
R5030	T6479	T6477	pobj	filters,with
R5031	T6480	T6467	punct	.,housed
R5032	T6482	T6483	prep	For,fed
R5033	T6484	T6485	amod	most,experiments
R5034	T6485	T6482	pobj	experiments,For
R5035	T6486	T6483	punct	", ",fed
R5036	T6487	T6488	det	the,mice
R5037	T6488	T6483	nsubjpass	mice,fed
R5038	T6489	T6483	auxpass	were,fed
R5039	T6490	T6491	nmod	NIH31,chow
R504	T669	T668	prep	of,susceptibility
R5040	T6491	T6483	dobj	chow,fed
R5041	T6492	T6490	punct	(,NIH31
R5042	T6493	T6494	nummod	6,%
R5043	T6494	T6495	compound	%,fat
R5044	T6495	T6490	appos	fat,NIH31
R5045	T6496	T6491	punct	),chow
R5046	T6497	T6498	advmod	ad,libitum
R5047	T6498	T6483	advmod	libitum,fed
R5048	T6499	T6483	punct	", ",fed
R5049	T6500	T6483	cc	and,fed
R505	T670	T671	det	the,nerve
R5050	T6501	T6502	poss	their,water
R5051	T6502	T6503	nsubjpass	water,acidified
R5052	T6503	T6483	conj	acidified,fed
R5053	T6504	T6503	auxpass	was,acidified
R5054	T6505	T6503	prep	to,acidified
R5055	T6506	T6505	pobj	pH,to
R5056	T6507	T6508	quantmod	2.8,3.2
R5057	T6508	T6506	nummod	3.2,pH
R5058	T6509	T6508	quantmod	to,3.2
R5059	T6510	T6483	punct	.,fed
R506	T671	T669	pobj	nerve,of
R5060	T6512	T6513	compound	B6,mice
R5061	T6513	T6514	nsubj	mice,develop
R5062	T6515	T6516	npadvmod	diet,induced
R5063	T6516	T6517	amod	induced,diabetes
R5064	T6517	T6514	dobj	diabetes,develop
R5065	T6518	T6519	advmod	when,maintained
R5066	T6519	T6514	advcl	maintained,develop
R5067	T6520	T6519	prep	on,maintained
R5068	T6521	T6522	det	a,diet
R5069	T6522	T6520	pobj	diet,on
R507	T672	T671	amod	optic,nerve
R5070	T6523	T6524	amod	high,fat
R5071	T6524	T6522	compound	fat,diet
R5072	T6525	T6526	punct	[,76
R5073	T6526	T6514	parataxis	76,develop
R5074	T6527	T6526	punct	],76
R5075	T6528	T6514	punct	.,develop
R5076	T6530	T6531	aux	To,ensure
R5077	T6531	T6532	advcl	ensure,fed
R5078	T6533	T6534	mark	that,analyzing
R5079	T6534	T6531	ccomp	analyzing,ensure
R508	T673	T671	cc	and,nerve
R5080	T6535	T6534	nsubj	we,analyzing
R5081	T6536	T6534	aux	were,analyzing
R5082	T6537	T6538	det	the,effect
R5083	T6538	T6534	dobj	effect,analyzing
R5084	T6539	T6538	prep	of,effect
R5085	T6540	T6539	pobj	age,of
R5086	T6541	T6540	cc	and,age
R5087	T6542	T6541	neg	not,and
R5088	T6543	T6540	conj	diabetes,age
R5089	T6544	T6532	punct	", ",fed
R509	T674	T671	conj	retina,nerve
R5090	T6545	T6546	det	the,mice
R5091	T6546	T6532	nsubjpass	mice,fed
R5092	T6547	T6546	compound	B6,mice
R5093	T6548	T6546	prep	in,mice
R5094	T6549	T6550	det	the,experiment
R5095	T6550	T6548	pobj	experiment,in
R5096	T6551	T6550	compound	aging,experiment
R5097	T6552	T6532	auxpass	were,fed
R5098	T6553	T6554	nmod	NIH31,chow
R5099	T6554	T6532	dobj	chow,fed
R51	T87	T86	pobj	age,as
R510	T675	T668	prep	to,susceptibility
R5100	T6555	T6553	punct	(,NIH31
R5101	T6556	T6557	nummod	4,%
R5102	T6557	T6558	compound	%,fat
R5103	T6558	T6553	appos	fat,NIH31
R5104	T6559	T6554	punct	),chow
R5105	T6560	T6532	punct	.,fed
R5106	T6562	T6563	nsubj	We,found
R5107	T6564	T6563	aux	have,found
R5108	T6565	T6566	det	no,differences
R5109	T6566	T6563	dobj	differences,found
R511	T676	T677	amod	glaucomatous,damage
R5110	T6567	T6566	prep	in,differences
R5111	T6568	T6567	pobj	IOP,in
R5112	T6569	T6563	prep	between,found
R5113	T6570	T6571	compound	B6,mice
R5114	T6571	T6569	pobj	mice,between
R5115	T6572	T6571	acl	housed,mice
R5116	T6573	T6572	prep	on,housed
R5117	T6574	T6575	det	the,versions
R5118	T6575	T6573	pobj	versions,on
R5119	T6576	T6577	nummod	4,%
R512	T677	T675	pobj	damage,to
R5120	T6577	T6578	nmod	%,fat
R5121	T6578	T6575	nmod	fat,versions
R5122	T6579	T6578	cc	and,fat
R5123	T6580	T6581	nummod	6,%
R5124	T6581	T6582	compound	%,fat
R5125	T6582	T6578	conj	fat,fat
R5126	T6583	T6575	prep	of,versions
R5127	T6584	T6585	det	this,diet
R5128	T6585	T6583	pobj	diet,of
R5129	T6586	T6587	advmod	otherwise,identical
R513	T678	T679	punct	[,20
R5130	T6587	T6585	amod	identical,diet
R5131	T6588	T6563	punct	.,found
R5132	T6590	T6591	det	The,mice
R5133	T6591	T6592	nsubjpass	mice,housed
R5134	T6593	T6592	auxpass	were,housed
R5135	T6594	T6592	dep	group,housed
R5136	T6595	T6592	cc	and,housed
R5137	T6596	T6597	det	the,cages
R5138	T6597	T6598	nsubjpass	cages,changed
R5139	T6598	T6592	conj	changed,housed
R514	T679	T652	parataxis	20,expected
R5140	T6599	T6598	auxpass	were,changed
R5141	T6600	T6601	nummod	one,time
R5142	T6601	T6598	npadvmod	time,changed
R5143	T6602	T6601	prep	per,time
R5144	T6603	T6602	pobj	week,per
R5145	T6604	T6598	punct	.,changed
R5146	T6606	T6607	mark	If,appeared
R5147	T6607	T6610	advcl	appeared,placed
R5148	T6608	T6609	det	any,cage
R5149	T6609	T6607	nsubj	cage,appeared
R515	T680	T679	punct	],20
R5150	T6611	T6607	oprd	soiled,appeared
R5151	T6612	T6607	prep	between,appeared
R5152	T6613	T6614	amod	scheduled,changes
R5153	T6614	T6612	pobj	changes,between
R5154	T6615	T6610	punct	", ",placed
R5155	T6616	T6617	det	the,mice
R5156	T6617	T6610	nsubjpass	mice,placed
R5157	T6618	T6610	auxpass	were,placed
R5158	T6619	T6610	prep	in,placed
R5159	T6620	T6621	det	a,cage
R516	T681	T652	punct	.,expected
R5160	T6621	T6619	pobj	cage,in
R5161	T6622	T6621	amod	clean,cage
R5162	T6623	T6610	punct	.,placed
R5163	T6625	T6626	det	The,environment
R5164	T6626	T6627	nsubjpass	environment,kept
R5165	T6628	T6627	auxpass	was,kept
R5166	T6629	T6627	prep	at,kept
R5167	T6630	T6631	nummod	21,°C
R5168	T6631	T6629	pobj	°C,at
R5169	T6632	T6627	prep	with,kept
R517	T683	T684	advmod	Very,little
R5170	T6633	T6634	det	a,cycle
R5171	T6634	T6632	pobj	cycle,with
R5172	T6635	T6636	nummod	14,hour
R5173	T6636	T6637	nmod	hour,light
R5174	T6637	T6634	nmod	light,cycle
R5175	T6638	T6639	punct	: ,dark
R5176	T6639	T6637	prep	dark,light
R5177	T6640	T6641	nummod	10,hour
R5178	T6641	T6639	npadvmod	hour,dark
R5179	T6642	T6627	punct	.,kept
R518	T684	T685	nsubjpass	little,known
R5180	T6644	T6645	det	The,colony
R5181	T6645	T6646	nsubjpass	colony,monitored
R5182	T6647	T6646	auxpass	was,monitored
R5183	T6648	T6646	prep	for,monitored
R5184	T6649	T6650	amod	specific,pathogens
R5185	T6650	T6648	pobj	pathogens,for
R5186	T6651	T6646	agent	by,monitored
R5187	T6652	T6653	det	The,Laboratory
R5188	T6653	T6655	poss	Laboratory,program
R5189	T6654	T6653	compound	Jackson,Laboratory
R519	T686	T685	auxpass	is,known
R5190	T6655	T6651	pobj	program,by
R5191	T6656	T6653	case	's,Laboratory
R5192	T6657	T6658	amod	routine,surveillance
R5193	T6658	T6655	compound	surveillance,program
R5194	T6659	T6660	punct	(,see
R5195	T6660	T6646	parataxis	see,monitored
R5196	T6661	T6660	prep	for,see
R5197	T6662	T6663	amod	specific,pathogens
R5198	T6663	T6661	pobj	pathogens,for
R5199	T6664	T6660	punct	),see
R52	T88	T87	punct	", ",age
R520	T687	T685	prep	about,known
R5200	T6665	T6646	punct	.,monitored
R5201	T6722	T6723	amod	Intraocular,pressure
R5202	T6725	T6726	amod	Intraocular,pressures
R5203	T6726	T6727	nsubjpass	pressures,measured
R5204	T6728	T6727	auxpass	were,measured
R5205	T6729	T6730	mark	as,described
R5206	T6730	T6727	advcl	described,measured
R5207	T6731	T6730	advmod	elsewhere,described
R5208	T6732	T6733	punct	[,77
R5209	T6733	T6727	parataxis	77,measured
R521	T688	T689	det	the,magnitude
R5210	T6734	T6733	nummod	13,77
R5211	T6735	T6733	punct	",",77
R5212	T6736	T6733	punct	],77
R5213	T6737	T6727	punct	.,measured
R5214	T6739	T6740	det	The,mice
R5215	T6740	T6741	nsubjpass	mice,acclimatized
R5216	T6742	T6741	auxpass	were,acclimatized
R5217	T6743	T6741	advmod	typically,acclimatized
R5218	T6744	T6741	prep	to,acclimatized
R5219	T6745	T6746	det	the,room
R522	T689	T687	pobj	magnitude,about
R5220	T6746	T6744	pobj	room,to
R5221	T6747	T6746	compound	procedure,room
R5222	T6748	T6741	prep	for,acclimatized
R5223	T6749	T6750	advmod	at,2
R5224	T6750	T6752	nummod	2,weeks
R5225	T6751	T6750	advmod	least,2
R5226	T6752	T6748	pobj	weeks,for
R5227	T6753	T6754	advmod	prior,to
R5228	T6754	T6752	prep	to,weeks
R5229	T6755	T6754	pobj	measurement,to
R523	T690	T689	prep	of,magnitude
R5230	T6756	T6752	punct	", ",weeks
R5231	T6757	T6752	cc	but,weeks
R5232	T6758	T6759	advmod	sometimes,weeks
R5233	T6759	T6752	conj	weeks,weeks
R5234	T6760	T6761	quantmod	between,1
R5235	T6761	T6759	nummod	1,weeks
R5236	T6762	T6761	cc	and,1
R5237	T6763	T6761	conj	2,1
R5238	T6764	T6741	punct	.,acclimatized
R5239	T6766	T6767	mark	Although,was
R524	T691	T690	pobj	IOP,of
R5240	T6767	T6769	advcl	was,intermixed
R5241	T6768	T6767	nsubj	it,was
R5242	T6770	T6767	neg	not,was
R5243	T6771	T6767	acomp	possible,was
R5244	T6772	T6773	aux	to,include
R5245	T6773	T6767	xcomp	include,was
R5246	T6774	T6775	det	all,strains
R5247	T6775	T6773	dobj	strains,include
R5248	T6776	T6773	prep	in,include
R5249	T6777	T6778	det	each,period
R525	T692	T689	prep	of,magnitude
R5250	T6778	T6776	pobj	period,in
R5251	T6779	T6778	compound	measurement,period
R5252	T6780	T6769	punct	", ",intermixed
R5253	T6781	T6769	nsubjpass	mice,intermixed
R5254	T6782	T6781	prep	of,mice
R5255	T6783	T6784	amod	different,strains
R5256	T6784	T6782	pobj	strains,of
R5257	T6785	T6769	auxpass	were,intermixed
R5258	T6786	T6769	punct	.,intermixed
R5259	T6788	T6789	mark	As,demonstrated
R526	T693	T694	amod	various,strains
R5260	T6789	T6790	advcl	demonstrated,are
R5261	T6791	T6789	advmod	here,demonstrated
R5262	T6792	T6790	punct	", ",are
R5263	T6793	T6794	det	the,IOPs
R5264	T6794	T6790	nsubj	IOPs,are
R5265	T6795	T6794	prep	of,IOPs
R5266	T6796	T6797	compound	C57BL,6J
R5267	T6797	T6795	pobj	6J,of
R5268	T6798	T6797	punct	/,6J
R5269	T6799	T6800	advmod	very,consistent
R527	T694	T692	pobj	strains,of
R5270	T6800	T6790	acomp	consistent,are
R5271	T6801	T6790	prep	over,are
R5272	T6802	T6801	pobj	time,over
R5273	T6803	T6790	cc	and,are
R5274	T6804	T6803	advmod	so,and
R5275	T6805	T6806	det	these,animals
R5276	T6806	T6807	nsubjpass	animals,interspersed
R5277	T6807	T6790	conj	interspersed,are
R5278	T6808	T6807	auxpass	were,interspersed
R5279	T6809	T6807	prep	with,interspersed
R528	T695	T694	compound	mouse,strains
R5280	T6810	T6811	amod	experimental,mice
R5281	T6811	T6809	pobj	mice,with
R5282	T6812	T6807	prep	during,interspersed
R5283	T6813	T6814	det	all,experiments
R5284	T6814	T6812	pobj	experiments,during
R5285	T6815	T6816	aux	to,ensure
R5286	T6816	T6807	advcl	ensure,interspersed
R5287	T6817	T6818	mark	that,drifted
R5288	T6818	T6816	advcl	drifted,ensure
R5289	T6819	T6818	nsubj	calibration,drifted
R529	T696	T689	cc	or,magnitude
R5290	T6820	T6818	aux	had,drifted
R5291	T6821	T6818	neg	not,drifted
R5292	T6822	T6818	cc	and,drifted
R5293	T6823	T6824	mark	that,functioning
R5294	T6824	T6818	conj	functioning,drifted
R5295	T6825	T6826	det	the,system
R5296	T6826	T6824	nsubj	system,functioning
R5297	T6827	T6824	aux	was,functioning
R5298	T6828	T6824	advmod	optimally,functioning
R5299	T6829	T6807	punct	.,interspersed
R53	T89	T87	conj	sex,age
R530	T697	T698	compound	IOP,fluctuation
R5300	T6831	T6832	advmod	Whenever,possible
R5301	T6832	T6833	advcl	possible,know
R5302	T6834	T6833	punct	", ",know
R5303	T6835	T6836	det	the,investigator
R5304	T6836	T6833	nsubj	investigator,know
R5305	T6837	T6836	acl	measuring,investigator
R5306	T6838	T6837	dobj	IOP,measuring
R5307	T6839	T6833	aux	did,know
R5308	T6840	T6833	neg	not,know
R5309	T6841	T6842	det	the,genotypes
R531	T698	T689	conj	fluctuation,magnitude
R5310	T6842	T6833	dobj	genotypes,know
R5311	T6843	T6842	prep	of,genotypes
R5312	T6844	T6845	det	the,animals
R5313	T6845	T6843	pobj	animals,of
R5314	T6846	T6833	punct	.,know
R5315	T6848	T6849	nsubj	It,was
R5316	T6850	T6849	neg	not,was
R5317	T6851	T6849	acomp	possible,was
R5318	T6852	T6853	aux	to,analyze
R5319	T6853	T6849	xcomp	analyze,was
R532	T699	T698	prep	in,fluctuation
R5320	T6854	T6855	det	all,groups
R5321	T6855	T6853	dobj	groups,analyze
R5322	T6856	T6855	compound	age,groups
R5323	T6857	T6855	prep	of,groups
R5324	T6858	T6859	det	each,strain
R5325	T6859	T6857	pobj	strain,of
R5326	T6860	T6853	prep	at,analyze
R5327	T6861	T6862	det	the,time
R5328	T6862	T6860	pobj	time,at
R5329	T6863	T6862	amod	same,time
R533	T700	T699	pobj	mice,in
R5330	T6864	T6853	prep	in,analyze
R5331	T6865	T6866	det	the,experiments
R5332	T6866	T6864	pobj	experiments,in
R5333	T6867	T6866	compound	aging,experiments
R5334	T6868	T6849	punct	.,was
R5335	T6870	T6871	advmod	Therefore,assessed
R5336	T6872	T6871	punct	", ",assessed
R5337	T6873	T6874	aux	to,control
R5338	T6874	T6871	advcl	control,assessed
R5339	T6875	T6874	prep	for,control
R534	T701	T698	prep	with,fluctuation
R5340	T6876	T6877	amod	potential,changes
R5341	T6877	T6875	pobj	changes,for
R5342	T6878	T6877	compound	IOP,changes
R5343	T6879	T6877	prep	due,changes
R5344	T6880	T6879	pcomp	to,due
R5345	T6881	T6882	compound	measurement,time
R5346	T6882	T6879	pobj	time,due
R5347	T6883	T6882	cc	and,time
R5348	T6884	T6883	neg	not,and
R5349	T6885	T6882	conj	age,time
R535	T702	T701	pobj	time,with
R5350	T6886	T6871	punct	", ",assessed
R5351	T6887	T6888	advmod	approximately,3
R5352	T6888	T6889	nummod	3,month
R5353	T6889	T6890	npadvmod	month,old
R5354	T6890	T6891	amod	old,mice
R5355	T6891	T6871	nsubjpass	mice,assessed
R5356	T6892	T6891	compound	B6,mice
R5357	T6893	T6871	auxpass	were,assessed
R5358	T6894	T6871	prep	at,assessed
R5359	T6895	T6896	det	the,time
R536	T703	T702	cc	or,time
R5360	T6896	T6894	pobj	time,at
R5361	T6897	T6896	amod	same,time
R5362	T6898	T6896	prep	as,time
R5363	T6899	T6900	det	each,group
R5364	T6900	T6898	pobj	group,as
R5365	T6901	T6900	compound	age,group
R5366	T6902	T6871	punct	.,assessed
R5367	T6904	T6905	det	All,measurements
R5368	T6905	T6908	nsubjpass	measurements,made
R5369	T6906	T6907	amod	dark,period
R537	T704	T705	amod	other,factors
R5370	T6907	T6905	compound	period,measurements
R5371	T6909	T6908	auxpass	were,made
R5372	T6910	T6911	quantmod	between,1
R5373	T6911	T6912	nummod	1,hours
R5374	T6912	T6915	npadvmod	hours,turned
R5375	T6913	T6911	cc	and,1
R5376	T6914	T6911	conj	3,1
R5377	T6915	T6908	advcl	turned,made
R5378	T6916	T6915	mark	after,turned
R5379	T6917	T6918	det	the,lights
R538	T705	T702	conj	factors,time
R5380	T6918	T6915	nsubj	lights,turned
R5381	T6919	T6915	prt	off,turned
R5382	T6920	T6908	punct	.,made
R5383	T6922	T6923	det	The,room
R5384	T6923	T6924	nsubjpass	room,equipped
R5385	T6925	T6924	auxpass	was,equipped
R5386	T6926	T6924	prep	with,equipped
R5387	T6927	T6928	nmod	dim,lights
R5388	T6928	T6926	pobj	lights,with
R5389	T6929	T6928	amod	red,lights
R539	T706	T685	punct	.,known
R5390	T6930	T6924	cc	and,equipped
R5391	T6931	T6932	nsubjpass	mice,protected
R5392	T6932	T6924	conj	protected,equipped
R5393	T6933	T6932	auxpass	were,protected
R5394	T6934	T6932	prep	from,protected
R5395	T6935	T6936	det	all,exposure
R5396	T6936	T6934	pobj	exposure,from
R5397	T6937	T6936	amod	light,exposure
R5398	T6938	T6932	prep	during,protected
R5399	T6939	T6940	compound	set,up
R54	T90	T89	cc	and,sex
R540	T708	T709	advmod	Previously,developed
R5400	T6940	T6938	pobj	up,during
R5401	T6941	T6932	punct	.,protected
R5402	T6943	T6944	det	Each,mouse
R5403	T6944	T6945	nsubjpass	mouse,exposed
R5404	T6946	T6945	auxpass	was,exposed
R5405	T6947	T6945	advmod	briefly,exposed
R5406	T6948	T6945	prep	to,exposed
R5407	T6949	T6950	det	the,light
R5408	T6950	T6948	pobj	light,to
R5409	T6951	T6950	amod	red,light
R541	T710	T709	punct	", ",developed
R5410	T6952	T6953	advmod	when,administered
R5411	T6953	T6945	advcl	administered,exposed
R5412	T6954	T6955	det	the,agents
R5413	T6955	T6953	nsubjpass	agents,administered
R5414	T6956	T6955	amod	anesthetic,agents
R5415	T6957	T6953	auxpass	were,administered
R5416	T6958	T6945	punct	.,exposed
R5417	T6960	T6961	advmod	When,achieved
R5418	T6961	T6965	advcl	achieved,placed
R5419	T6962	T6963	amod	adequate,anesthesia
R542	T711	T709	nsubj	we,developed
R5420	T6963	T6961	nsubjpass	anesthesia,achieved
R5421	T6964	T6961	auxpass	was,achieved
R5422	T6966	T6961	punct	(,achieved
R5423	T6967	T6961	prep	after,achieved
R5424	T6968	T6969	quantmod	3,4
R5425	T6969	T6971	nummod	4,minutes
R5426	T6970	T6969	quantmod	to,4
R5427	T6971	T6967	pobj	minutes,after
R5428	T6972	T6965	punct	),placed
R5429	T6973	T6965	punct	", ",placed
R543	T712	T713	det	a,method
R5430	T6974	T6975	det	the,mouse
R5431	T6975	T6965	nsubjpass	mouse,placed
R5432	T6976	T6965	auxpass	was,placed
R5433	T6977	T6965	prep	on,placed
R5434	T6978	T6979	det	the,platform
R5435	T6979	T6977	pobj	platform,on
R5436	T6980	T6979	compound	measurement,platform
R5437	T6981	T6965	cc	and,placed
R5438	T6982	T6983	det	the,light
R5439	T6983	T6985	nsubjpass	light,turned
R544	T713	T709	dobj	method,developed
R5440	T6984	T6983	amod	white,light
R5441	T6985	T6965	conj	turned,placed
R5442	T6986	T6983	prep	of,light
R5443	T6987	T6988	det	the,microscope
R5444	T6988	T6986	pobj	microscope,of
R5445	T6989	T6985	auxpass	was,turned
R5446	T6990	T6985	prt	on,turned
R5447	T6991	T6985	punct	(,turned
R5448	T6992	T6985	prep	for,turned
R5449	T6993	T6994	advmod	approximately,1
R545	T714	T715	aux	to,measure
R5450	T6994	T6995	nummod	1,minutes
R5451	T6995	T6992	pobj	minutes,for
R5452	T6996	T6994	cc	and,1
R5453	T6997	T6998	quantmod	a,half
R5454	T6998	T6994	conj	half,1
R5455	T6999	T6985	punct	),turned
R5456	T7000	T7001	aux	to,allow
R5457	T7001	T6985	advcl	allow,turned
R5458	T7002	T7003	amod	ocular,cannulation
R5459	T7003	T7001	dobj	cannulation,allow
R546	T715	T713	advcl	measure,method
R5460	T7004	T7003	punct	", ",cannulation
R5461	T7005	T7006	nmod	IOP,measurement
R5462	T7006	T7007	nmod	measurement,tests
R5463	T7007	T7003	appos	tests,cannulation
R5464	T7008	T7006	cc	and,measurement
R5465	T7009	T7006	conj	post-measurement,measurement
R5466	T7010	T7011	punct	[,13
R5467	T7011	T7007	parataxis	13,tests
R5468	T7012	T7011	punct	],13
R5469	T7013	T7014	dep	that,guard
R547	T716	T715	dobj	IOP,measure
R5470	T7014	T7007	relcl	guard,tests
R5471	T7015	T7014	prep	against,guard
R5472	T7016	T7017	amod	artifactual,data
R5473	T7017	T7015	pobj	data,against
R5474	T7018	T6965	punct	.,placed
R5475	T7020	T7021	det	The,light
R5476	T7021	T7023	nsubjpass	light,used
R5477	T7022	T7021	amod	white,light
R5478	T7024	T7023	auxpass	was,used
R5479	T7025	T7023	prep	at,used
R548	T717	T716	prep	in,IOP
R5480	T7026	T7027	advmod	very,low
R5481	T7027	T7028	amod	low,intensity
R5482	T7028	T7025	pobj	intensity,at
R5483	T7029	T7023	cc	and,used
R5484	T7030	T7023	conj	was,used
R5485	T7031	T7030	acomp	dim,was
R5486	T7032	T7023	cc	but,used
R5487	T7033	T7034	nsubj	we,rule
R5488	T7034	T7023	conj	rule,used
R5489	T7035	T7034	aux	can,rule
R549	T718	T717	pobj	mice,in
R5490	T7036	T7034	neg	not,rule
R5491	T7037	T7034	prt	out,rule
R5492	T7038	T7039	det	the,possibility
R5493	T7039	T7034	dobj	possibility,rule
R5494	T7040	T7041	mark	that,altered
R5495	T7041	T7039	acl	altered,possibility
R5496	T7042	T7043	det	this,exposure
R5497	T7043	T7041	nsubj	exposure,altered
R5498	T7044	T7043	amod	brief,exposure
R5499	T7045	T7046	det	the,IOP
R55	T91	T89	conj	time,sex
R550	T719	T709	cc	and,developed
R5500	T7046	T7041	dobj	IOP,altered
R5501	T7047	T7034	punct	.,rule
R5502	T7049	T7050	det	All,mice
R5503	T7050	T7052	nsubjpass	mice,protected
R5504	T7051	T7050	amod	other,mice
R5505	T7053	T7052	auxpass	were,protected
R5506	T7054	T7052	prep	from,protected
R5507	T7055	T7056	amod	light,exposure
R5508	T7056	T7054	pobj	exposure,from
R5509	T7057	T7052	prep	throughout,protected
R551	T720	T709	conj	reported,developed
R5510	T7058	T7059	det	the,time
R5511	T7059	T7057	pobj	time,throughout
R5512	T7060	T7061	det	an,mouse
R5513	T7061	T7063	nsubjpass	mouse,analyzed
R5514	T7062	T7061	amod	individual,mouse
R5515	T7063	T7059	advcl	analyzed,time
R5516	T7064	T7063	auxpass	was,analyzed
R5517	T7065	T7052	punct	.,protected
R5518	T7102	T7103	compound	Blood,pressure
R5519	T7105	T7106	det	The,pressures
R552	T721	T722	amod	initial,findings
R5520	T7106	T7108	nsubjpass	pressures,measured
R5521	T7107	T7106	compound	blood,pressures
R5522	T7109	T7106	prep	of,pressures
R5523	T7110	T7111	amod	conscious,mice
R5524	T7111	T7109	pobj	mice,of
R5525	T7112	T7111	prep	of,mice
R5526	T7113	T7114	det	each,strain
R5527	T7114	T7112	pobj	strain,of
R5528	T7115	T7111	punct	(,mice
R5529	T7116	T7117	quantmod	6,12
R553	T722	T720	dobj	findings,reported
R5530	T7117	T7119	nummod	12,females
R5531	T7118	T7117	quantmod	to,12
R5532	T7119	T7111	appos	females,mice
R5533	T7120	T7119	prep	per,females
R5534	T7121	T7120	pobj	strain,per
R5535	T7122	T7108	punct	),measured
R5536	T7123	T7108	auxpass	were,measured
R5537	T7124	T7108	prep	with,measured
R5538	T7125	T7126	det	a,system
R5539	T7126	T7124	pobj	system,with
R554	T723	T722	prep	on,findings
R5540	T7127	T7128	compound	tail,cuff
R5541	T7128	T7126	compound	cuff,system
R5542	T7129	T7128	punct	-,cuff
R5543	T7130	T7131	mark	as,reported
R5544	T7131	T7108	advcl	reported,measured
R5545	T7132	T7133	punct	[,78
R5546	T7133	T7131	parataxis	78,reported
R5547	T7134	T7133	punct	],78
R5548	T7135	T7108	punct	", ",measured
R5549	T7136	T7108	prep	except,measured
R555	T724	T725	det	the,magnitude
R5550	T7137	T7138	mark	that,used
R5551	T7138	T7136	pcomp	used,except
R5552	T7139	T7140	nummod	5,days
R5553	T7140	T7138	nsubjpass	days,used
R5554	T7141	T7140	prep	of,days
R5555	T7142	T7141	pobj	training,of
R5556	T7143	T7138	auxpass	were,used
R5557	T7144	T7108	punct	.,measured
R5558	T7146	T7147	det	The,mice
R5559	T7147	T7148	nsubjpass	mice,analyzed
R556	T725	T723	pobj	magnitude,on
R5560	T7149	T7148	auxpass	were,analyzed
R5561	T7150	T7148	prep	in,analyzed
R5562	T7151	T7152	det	the,room
R5563	T7152	T7150	pobj	room,in
R5564	T7153	T7152	amod	same,room
R5565	T7154	T7152	compound	procedure,room
R5566	T7155	T7156	mark	as,used
R5567	T7156	T7152	advcl	used,room
R5568	T7157	T7156	auxpass	was,used
R5569	T7158	T7156	prep	for,used
R557	T726	T725	prep	of,magnitude
R5570	T7159	T7160	compound	IOP,measurment
R5571	T7160	T7158	pobj	measurment,for
R5572	T7161	T7148	punct	.,analyzed
R5573	T7175	T7176	amod	Clinical,examinations
R5574	T7178	T7179	prep	For,examined
R5575	T7180	T7181	amod	most,strains
R5576	T7181	T7178	pobj	strains,For
R5577	T7182	T7179	punct	", ",examined
R5578	T7183	T7184	amod	anterior,chambers
R5579	T7184	T7179	nsubjpass	chambers,examined
R558	T727	T728	compound	mouse,IOP
R5580	T7185	T7179	auxpass	were,examined
R5581	T7186	T7179	prep	with,examined
R5582	T7187	T7188	det	a,biomicroscope
R5583	T7188	T7186	pobj	biomicroscope,with
R5584	T7189	T7190	amod	slit,lamp
R5585	T7190	T7188	compound	lamp,biomicroscope
R5586	T7191	T7192	punct	[,16
R5587	T7192	T7179	parataxis	16,examined
R5588	T7193	T7192	punct	],16
R5589	T7194	T7179	punct	.,examined
R559	T728	T726	pobj	IOP,of
R5590	T7196	T7197	advmod	At,8
R5591	T7197	T7199	nummod	8,mice
R5592	T7198	T7197	advmod	least,8
R5593	T7199	T7200	nsubjpass	mice,evaluated
R5594	T7201	T7199	prep	of,mice
R5595	T7202	T7203	det	each,strain
R5596	T7203	T7201	pobj	strain,of
R5597	T7204	T7203	acl	shown,strain
R5598	T7205	T7204	prep	in,shown
R5599	T7206	T7205	pobj	figure,in
R56	T92	T91	prep	of,time
R560	T729	T730	punct	[,13
R5600	T7207	T7206	nummod	1,figure
R5601	T7208	T7200	auxpass	were,evaluated
R5602	T7209	T7200	punct	.,evaluated
R5603	T7211	T7212	advmod	However,evaluated
R5604	T7213	T7212	punct	", ",evaluated
R5605	T7214	T7215	det	the,chambers
R5606	T7215	T7212	nsubjpass	chambers,evaluated
R5607	T7216	T7215	amod	anterior,chambers
R5608	T7217	T7215	prep	of,chambers
R5609	T7218	T7219	compound	C57BLKS,J
R561	T730	T720	parataxis	13,reported
R5610	T7219	T7221	compound	J,mice
R5611	T7220	T7219	punct	/,J
R5612	T7221	T7217	pobj	mice,of
R5613	T7222	T7212	auxpass	were,evaluated
R5614	T7223	T7212	advmod	only,evaluated
R5615	T7224	T7212	prep	under,evaluated
R5616	T7225	T7226	det	a,microscope
R5617	T7226	T7224	pobj	microscope,under
R5618	T7227	T7226	compound	dissection,microscope
R5619	T7228	T7212	prep	at,evaluated
R562	T731	T730	punct	],13
R5620	T7229	T7230	det	the,time
R5621	T7230	T7228	pobj	time,at
R5622	T7231	T7230	prep	of,time
R5623	T7232	T7233	compound	IOP,measurement
R5624	T7233	T7231	pobj	measurement,of
R5625	T7234	T7212	punct	.,evaluated
R5626	T7250	T7251	amod	Histological,analysis
R5627	T7253	T7254	nsubj	Eyes,fixed
R5628	T7255	T7253	prep	from,Eyes
R5629	T7256	T7257	advmod	at,2
R563	T732	T709	punct	.,developed
R5630	T7257	T7259	nummod	2,mice
R5631	T7258	T7257	advmod	least,2
R5632	T7259	T7255	pobj	mice,from
R5633	T7260	T7259	prep	of,mice
R5634	T7261	T7262	det	the,strains
R5635	T7262	T7260	pobj	strains,of
R5636	T7263	T7262	amod	listed,strains
R5637	T7264	T7254	aux	were,fixed
R5638	T7265	T7266	punct	(,paraformaldehyde
R5639	T7266	T7254	parataxis	paraformaldehyde,fixed
R564	T734	T735	det	The,procedure
R5640	T7267	T7268	nummod	4,%
R5641	T7268	T7266	compound	%,paraformaldehyde
R5642	T7269	T7266	cc	or,paraformaldehyde
R5643	T7270	T7271	poss	Fekete,fixative
R5644	T7271	T7266	conj	fixative,paraformaldehyde
R5645	T7272	T7270	case	's,Fekete
R5646	T7273	T7274	compound	acid,formalin
R5647	T7274	T7271	compound	formalin,fixative
R5648	T7275	T7274	punct	-,formalin
R5649	T7276	T7274	compound	alcohol,formalin
R565	T735	T736	nsubj	procedure,involves
R5650	T7277	T7274	punct	-,formalin
R5651	T7278	T7266	punct	),paraformaldehyde
R5652	T7279	T7254	dep	processed,fixed
R5653	T7280	T7254	punct	", ",fixed
R5654	T7281	T7282	dep	paraffin,embedded
R5655	T7282	T7254	conj	embedded,fixed
R5656	T7283	T7282	cc	and,embedded
R5657	T7284	T7282	conj	sectioned,embedded
R5658	T7285	T7286	mark	as,reported
R5659	T7286	T7254	advcl	reported,fixed
R566	T737	T738	amod	direct,measurement
R5660	T7287	T7286	advmod	previously,reported
R5661	T7288	T7289	punct	[,79
R5662	T7289	T7254	parataxis	79,fixed
R5663	T7290	T7289	nummod	15,79
R5664	T7291	T7289	punct	",",79
R5665	T7292	T7289	punct	],79
R5666	T7293	T7254	punct	", ",fixed
R5667	T7294	T7254	prep	except,fixed
R5668	T7295	T7296	mark	that,buffered
R5669	T7296	T7294	pcomp	buffered,except
R567	T738	T736	dobj	measurement,involves
R5670	T7297	T7298	det	the,paraformaldehyde
R5671	T7298	T7296	nsubjpass	paraformaldehyde,buffered
R5672	T7299	T7296	auxpass	was,buffered
R5673	T7300	T7296	prep	with,buffered
R5674	T7301	T7302	nummod	0.1,M
R5675	T7302	T7303	compound	M,phosphate
R5676	T7303	T7304	compound	phosphate,buffer
R5677	T7304	T7300	pobj	buffer,with
R5678	T7305	T7254	punct	.,fixed
R5679	T7307	T7308	det	All,strains
R568	T739	T738	prep	of,measurement
R5680	T7308	T7309	nsubjpass	strains,evaluated
R5681	T7310	T7311	amod	other,than
R5682	T7311	T7308	prep	than,strains
R5683	T7312	T7313	nmod	CBA,CaHN
R5684	T7313	T7315	nmod	CaHN,strains
R5685	T7314	T7313	punct	/,CaHN
R5686	T7315	T7311	pobj	strains,than
R5687	T7316	T7313	cc	and,CaHN
R5688	T7317	T7318	compound	C57BLKS,J
R5689	T7318	T7313	conj	J,CaHN
R569	T740	T739	pobj	pressure,of
R5690	T7319	T7318	punct	/,J
R5691	T7320	T7309	auxpass	were,evaluated
R5692	T7321	T7309	punct	.,evaluated
R5693	T7323	T7324	det	The,eyes
R5694	T7324	T7325	nsubjpass	eyes,fixed
R5695	T7326	T7324	prep	of,eyes
R5696	T7327	T7328	nmod	CBA,CaJ
R5697	T7328	T7330	nmod	CaJ,mice
R5698	T7329	T7328	punct	/,CaJ
R5699	T7330	T7326	pobj	mice,of
R57	T93	T92	pobj	day,of
R570	T741	T738	prep	following,measurement
R5700	T7331	T7328	cc	and,CaJ
R5701	T7332	T7333	compound	BALB,cJ
R5702	T7333	T7328	conj	cJ,CaJ
R5703	T7334	T7333	punct	/,cJ
R5704	T7335	T7325	auxpass	were,fixed
R5705	T7336	T7325	advmod	also,fixed
R5706	T7337	T7325	cc	and,fixed
R5707	T7338	T7325	conj	processed,fixed
R5708	T7339	T7338	prep	for,processed
R5709	T7340	T7341	compound	plastic,embedding
R571	T742	T741	pobj	cannulation,following
R5710	T7341	T7339	pobj	embedding,for
R5711	T7342	T7343	punct	(,Historesin
R5712	T7343	T7338	parataxis	Historesin,processed
R5713	T7344	T7343	punct	", ",Historesin
R5714	T7345	T7343	npadvmod	Leica,Historesin
R5715	T7346	T7343	punct	", ",Historesin
R5716	T7347	T7343	npadvmod	Heidelberg,Historesin
R5717	T7348	T7343	punct	", ",Historesin
R5718	T7349	T7343	npadvmod	Germany,Historesin
R5719	T7350	T7343	punct	),Historesin
R572	T743	T742	prep	of,cannulation
R5720	T7351	T7325	punct	", ",fixed
R5721	T7352	T7325	cc	and,fixed
R5722	T7353	T7325	conj	sectioned,fixed
R5723	T7354	T7355	mark	as,reported
R5724	T7355	T7353	advcl	reported,sectioned
R5725	T7356	T7355	advmod	previously,reported
R5726	T7357	T7358	punct	[,79
R5727	T7358	T7353	parataxis	79,sectioned
R5728	T7359	T7358	nummod	14,79
R5729	T7360	T7358	punct	",",79
R573	T744	T745	det	the,chamber
R5730	T7361	T7358	punct	],79
R5731	T7362	T7325	punct	.,fixed
R5732	T7364	T7365	amod	Saggital,sections
R5733	T7365	T7366	nsubjpass	sections,collected
R5734	T7367	T7365	prep	including,sections
R5735	T7368	T7369	det	the,pupil
R5736	T7369	T7367	pobj	pupil,including
R5737	T7370	T7369	cc	and,pupil
R5738	T7371	T7372	amod	optic,nerve
R5739	T7372	T7369	conj	nerve,pupil
R574	T745	T743	pobj	chamber,of
R5740	T7373	T7366	auxpass	were,collected
R5741	T7374	T7366	cc	and,collected
R5742	T7375	T7366	conj	analyzed,collected
R5743	T7376	T7377	mark	as,contain
R5744	T7377	T7375	advcl	contain,analyzed
R5745	T7378	T7377	nsubj	they,contain
R5746	T7379	T7380	amod	most,structures
R5747	T7380	T7377	dobj	structures,contain
R5748	T7381	T7380	amod	ocular,structures
R5749	T7382	T7366	punct	.,collected
R575	T746	T745	amod	anterior,chamber
R5750	T7415	T7414	prep	of,Analysis
R5751	T7416	T7415	pobj	Myoc,of
R5752	T7418	T7419	nsubjpass	Exons,amplified
R5753	T7420	T7418	cc	and,Exons
R5754	T7421	T7422	det	the,promoter
R5755	T7422	T7418	conj	promoter,Exons
R5756	T7423	T7422	amod	proximal,promoter
R5757	T7424	T7422	prep	of,promoter
R5758	T7425	T7426	det	the,gene
R5759	T7426	T7424	pobj	gene,of
R576	T747	T736	punct	.,involves
R5760	T7427	T7426	compound	mouse,gene
R5761	T7428	T7426	compound	Myoc,gene
R5762	T7429	T7419	auxpass	were,amplified
R5763	T7430	T7419	prep	from,amplified
R5764	T7431	T7432	nmod	mouse,DNA
R5765	T7432	T7430	pobj	DNA,from
R5766	T7433	T7432	amod	genomic,DNA
R5767	T7434	T7419	advcl	using,amplified
R5768	T7435	T7436	det	the,combinations
R5769	T7436	T7434	dobj	combinations,using
R577	T749	T750	det	The,experiments
R5770	T7437	T7436	amod	following,combinations
R5771	T7438	T7436	prep	of,combinations
R5772	T7439	T7438	pobj	primers,of
R5773	T7440	T7419	punct	:,amplified
R5774	T7442	T7443	dep	Exon,cttgcaggagaactttccagaa
R5775	T7444	T7442	nummod	1,Exon
R5776	T7445	T7443	punct	: ,cttgcaggagaactttccagaa
R5777	T7446	T7443	nummod	5,cttgcaggagaactttccagaa
R5778	T7447	T7446	punct	',5
R5779	T7448	T7503	punct	',tgaagccatactttaccaaccat
R578	T750	T752	nsubj	experiments,demonstrated
R5780	T7449	T7503	cc	and,tgaagccatactttaccaaccat
R5781	T7450	T7451	nummod	5,caaaagggagaagtctaacttc
R5782	T7451	T7503	conj	caaaagggagaagtctaacttc,tgaagccatactttaccaaccat
R5783	T7452	T7450	punct	',5
R5784	T7453	T7443	punct	-,cttgcaggagaactttccagaa
R5785	T7454	T7443	punct	-,cttgcaggagaactttccagaa
R5786	T7455	T7443	nummod	3,cttgcaggagaactttccagaa
R5787	T7456	T7451	punct	-,caaaagggagaagtctaacttc
R5788	T7457	T7451	punct	-,caaaagggagaagtctaacttc
R5789	T7458	T7443	punct	',cttgcaggagaactttccagaa
R579	T751	T750	amod	initial,experiments
R5790	T7459	T7443	cc	and,cttgcaggagaactttccagaa
R5791	T7460	T7451	nummod	3,caaaagggagaagtctaacttc
R5792	T7461	T7451	punct	',caaaagggagaagtctaacttc
R5793	T7462	T7463	nummod	5,atctcgaaggagattgttatagg
R5794	T7463	T7443	conj	atctcgaaggagattgttatagg,cttgcaggagaactttccagaa
R5795	T7464	T7462	punct	',5
R5796	T7466	T7463	punct	-,atctcgaaggagattgttatagg
R5797	T7467	T7463	punct	-,atctcgaaggagattgttatagg
R5798	T7468	T7469	dep	Exon,agtcaaggctcacagagctaa
R5799	T7470	T7463	nummod	3,atctcgaaggagattgttatagg
R58	T94	T82	prep	on,effects
R580	T753	T754	mark	that,has
R5800	T7471	T7468	nummod	3,Exon
R5801	T7472	T7463	punct	',atctcgaaggagattgttatagg
R5802	T7473	T7469	punct	: ,agtcaaggctcacagagctaa
R5803	T7474	T7469	nummod	5,agtcaaggctcacagagctaa
R5804	T7476	T7478	nummod	5,gaccagctggagacccaaaccag
R5805	T7477	T7474	punct	',5
R5806	T7479	T7469	punct	-,agtcaaggctcacagagctaa
R5807	T7480	T7469	punct	-,agtcaaggctcacagagctaa
R5808	T7481	T7469	nummod	3,agtcaaggctcacagagctaa
R5809	T7482	T7476	punct	',5
R581	T754	T752	ccomp	has,demonstrated
R5810	T7483	T7478	punct	-,gaccagctggagacccaaaccag
R5811	T7484	T7478	punct	-,gaccagctggagacccaaaccag
R5812	T7485	T7478	nummod	3,gaccagctggagacccaaaccag
R5813	T7486	T7478	punct	',gaccagctggagacccaaaccag
R5814	T7487	T7478	cc	and,gaccagctggagacccaaaccag
R5815	T7488	T7489	nummod	5,gctcagatccactgacctaaa
R5816	T7489	T7478	conj	gctcagatccactgacctaaa,gaccagctggagacccaaaccag
R5817	T7490	T7488	punct	',5
R5818	T7491	T7489	punct	-,gctcagatccactgacctaaa
R5819	T7492	T7489	punct	-,gctcagatccactgacctaaa
R582	T755	T754	prep	in,has
R5820	T7493	T7469	punct	',agtcaaggctcacagagctaa
R5821	T7494	T7469	cc	and,agtcaaggctcacagagctaa
R5822	T7495	T7489	nummod	3,gctcagatccactgacctaaa
R5823	T7496	T7489	punct	',gctcagatccactgacctaaa
R5824	T7498	T7503	dep	Exon,tgaagccatactttaccaaccat
R5825	T7499	T7500	nummod	5,aagagtagctgctcaccgtgtacaag
R5826	T7500	T7469	conj	aagagtagctgctcaccgtgtacaag,agtcaaggctcacagagctaa
R5827	T7501	T7499	punct	',5
R5828	T7502	T7500	punct	-,aagagtagctgctcaccgtgtacaag
R5829	T7504	T7498	nummod	2,Exon
R583	T756	T757	poss	our,hands
R5830	T7505	T7503	punct	: ,tgaagccatactttaccaaccat
R5831	T7506	T7503	nummod	5,tgaagccatactttaccaaccat
R5832	T7507	T7506	punct	',5
R5833	T7508	T7503	punct	-,tgaagccatactttaccaaccat
R5834	T7509	T7503	punct	-,tgaagccatactttaccaaccat
R5835	T7510	T7503	nummod	3,tgaagccatactttaccaaccat
R5836	T7511	T7500	punct	-,aagagtagctgctcaccgtgtacaag
R5837	T7512	T7500	nummod	3,aagagtagctgctcaccgtgtacaag
R5838	T7513	T7500	punct	',aagagtagctgctcaccgtgtacaag
R5839	T7515	T7516	nummod	5,agacattgacttagctgtggat
R584	T757	T755	pobj	hands,in
R5840	T7517	T7515	punct	',5
R5841	T7518	T7516	punct	-,agacattgacttagctgtggat
R5842	T7519	T7516	punct	-,agacattgacttagctgtggat
R5843	T7520	T7516	nummod	3,agacattgacttagctgtggat
R5844	T7521	T7516	punct	',agacattgacttagctgtggat
R5845	T7522	T7516	cc	and,agacattgacttagctgtggat
R5846	T7523	T7524	nummod	5,cggaacttcaccttttctggc
R5847	T7524	T7516	conj	cggaacttcaccttttctggc,agacattgacttagctgtggat
R5848	T7525	T7523	punct	',5
R5849	T7526	T7524	punct	-,cggaacttcaccttttctggc
R585	T758	T759	amod	careful,cannulation
R5850	T7527	T7524	punct	-,cggaacttcaccttttctggc
R5851	T7528	T7524	nummod	3,cggaacttcaccttttctggc
R5852	T7529	T7524	punct	',cggaacttcaccttttctggc
R5853	T7531	T7532	dep	Promoter,taggagaagtctcattatactgc
R5854	T7533	T7532	punct	: ,taggagaagtctcattatactgc
R5855	T7534	T7532	nummod	5,taggagaagtctcattatactgc
R5856	T7535	T7534	punct	',5
R5857	T7536	T7532	punct	-,taggagaagtctcattatactgc
R5858	T7537	T7532	punct	-,taggagaagtctcattatactgc
R5859	T7538	T7532	nummod	3,taggagaagtctcattatactgc
R586	T759	T754	nsubj	cannulation,has
R5860	T7539	T7532	punct	',taggagaagtctcattatactgc
R5861	T7540	T7532	cc	and,taggagaagtctcattatactgc
R5862	T7541	T7542	nummod	5,ttcactggaccagcataagga
R5863	T7542	T7532	conj	ttcactggaccagcataagga,taggagaagtctcattatactgc
R5864	T7543	T7542	punct	',ttcactggaccagcataagga
R5865	T7544	T7542	punct	-,ttcactggaccagcataagga
R5866	T7545	T7542	punct	-,ttcactggaccagcataagga
R5867	T7546	T7542	nummod	3,ttcactggaccagcataagga
R5868	T7547	T7542	punct	',ttcactggaccagcataagga
R5869	T7549	T7550	nummod	5,tctgaggatgttcacaggtttat
R587	T760	T759	amod	ocular,cannulation
R5870	T7551	T7549	punct	',5
R5871	T7552	T7550	punct	-,tctgaggatgttcacaggtttat
R5872	T7553	T7550	punct	-,tctgaggatgttcacaggtttat
R5873	T7554	T7550	nummod	3,tctgaggatgttcacaggtttat
R5874	T7555	T7550	punct	',tctgaggatgttcacaggtttat
R5875	T7556	T7550	cc	and,tctgaggatgttcacaggtttat
R5876	T7557	T7558	nummod	5,tcttctggaaagttctcctgca
R5877	T7558	T7550	conj	tcttctggaaagttctcctgca,tctgaggatgttcacaggtttat
R5878	T7559	T7557	punct	',5
R5879	T7560	T7558	punct	-,tcttctggaaagttctcctgca
R588	T761	T762	det	a,effect
R5880	T7561	T7558	punct	-,tcttctggaaagttctcctgca
R5881	T7562	T7558	nummod	3,tcttctggaaagttctcctgca
R5882	T7563	T7558	punct	',tcttctggaaagttctcctgca
R5883	T7565	T7566	nsubj	Samples,underwent
R5884	T7567	T7568	nummod	30,cycles
R5885	T7568	T7566	dobj	cycles,underwent
R5886	T7569	T7568	prep	of,cycles
R5887	T7570	T7569	pobj	amplification,of
R5888	T7571	T7568	prep	with,cycles
R5889	T7572	T7573	compound	Perkin,Taq
R589	T762	T754	dobj	effect,has
R5890	T7573	T7576	compound	Taq,polymerase
R5891	T7574	T7573	punct	-,Taq
R5892	T7575	T7573	compound	Elmer,Taq
R5893	T7576	T7571	pobj	polymerase,with
R5894	T7577	T7576	prep	in,polymerase
R5895	T7578	T7579	det	a,Cycler
R5896	T7579	T7577	pobj	Cycler,in
R5897	T7580	T7579	compound	PTC,Cycler
R5898	T7581	T7579	compound	Thermal,Cycler
R5899	T7582	T7583	punct	(,Research
R59	T95	T94	pobj	IOP,on
R590	T763	T764	advmod	very,minor
R5900	T7583	T7576	parataxis	Research,polymerase
R5901	T7584	T7583	compound	MJ,Research
R5902	T7585	T7583	punct	", ",Research
R5903	T7586	T7583	npadvmod	MA,Research
R5904	T7587	T7583	punct	),Research
R5905	T7588	T7589	punct	(,°
R5906	T7589	T7576	parataxis	°,polymerase
R5907	T7590	T7591	nummod	94,°
R5908	T7591	T7589	dep	°,°
R5909	T7592	T7591	prep	for,°
R591	T764	T762	amod	minor,effect
R5910	T7593	T7594	nummod	40,sec
R5911	T7594	T7592	pobj	sec,for
R5912	T7595	T7589	punct	", ",°
R5913	T7596	T7597	nummod	57,°
R5914	T7597	T7589	dep	°,°
R5915	T7598	T7597	prep	for,°
R5916	T7599	T7600	nummod	1,min
R5917	T7600	T7598	pobj	min,for
R5918	T7601	T7589	punct	", ",°
R5919	T7602	T7589	nummod	72,°
R592	T765	T762	prep	on,effect
R5920	T7603	T7589	prep	for,°
R5921	T7604	T7605	nummod	2,min
R5922	T7605	T7603	pobj	min,for
R5923	T7606	T7589	punct	),°
R5924	T7607	T7566	punct	.,underwent
R5925	T7609	T7610	det	The,products
R5926	T7610	T7612	dep	products,purified
R5927	T7611	T7610	compound	PCR,products
R5928	T7613	T7612	nsubj	we,purified
R5929	T7614	T7612	cc	and,purified
R593	T766	T765	pobj	IOP,on
R5930	T7615	T7612	conj	sequenced,purified
R5931	T7616	T7617	mark	as,described
R5932	T7617	T7612	advcl	described,purified
R5933	T7618	T7619	punct	[,22
R5934	T7619	T7612	parataxis	22,purified
R5935	T7620	T7619	punct	],22
R5936	T7621	T7612	punct	.,purified
R5937	T7658	T7659	det	An,range
R5938	T7660	T7661	advmod	almost,two-fold
R5939	T7661	T7659	nummod	two-fold,range
R594	T767	T768	punct	(,mode
R5940	T7662	T7659	prep	of,range
R5941	T7663	T7662	pobj	IOP,of
R5942	T7664	T7659	prep	between,range
R5943	T7665	T7666	advmod	genetically,distinct
R5944	T7666	T7667	amod	distinct,strains
R5945	T7667	T7664	pobj	strains,between
R5946	T7668	T7667	compound	mouse,strains
R5947	T7669	T7659	punct	.,range
R5948	T7671	T7672	amod	Mean,IOP
R5949	T7672	T7673	nsubjpass	IOP,shown
R595	T768	T754	parataxis	mode,has
R5950	T7674	T7672	punct	±,IOP
R5951	T7675	T7672	appos	SEM,IOP
R5952	T7676	T7673	auxpass	is,shown
R5953	T7677	T7673	prep	for,shown
R5954	T7678	T7679	det	each,strain
R5955	T7679	T7677	pobj	strain,for
R5956	T7680	T7673	punct	.,shown
R5957	T7682	T7683	quantmod	Twelve,25
R5958	T7683	T7685	nummod	25,mice
R5959	T7684	T7683	quantmod	to,25
R596	T769	T768	dep	average,mode
R5960	T7685	T7686	nsubjpass	mice,analyzed
R5961	T7687	T7686	auxpass	were,analyzed
R5962	T7688	T7686	prep	for,analyzed
R5963	T7689	T7690	det	each,strain
R5964	T7690	T7688	pobj	strain,for
R5965	T7691	T7692	punct	(,20
R5966	T7692	T7686	parataxis	20,analyzed
R5967	T7693	T7692	advmod	typically,20
R5968	T7694	T7692	quantmod	18,20
R5969	T7695	T7692	quantmod	to,20
R597	T770	T769	prep	of,average
R5970	T7696	T7692	punct	),20
R5971	T7697	T7686	punct	", ",analyzed
R5972	T7698	T7686	prep	except,analyzed
R5973	T7699	T7698	prep	for,except
R5974	T7700	T7701	compound	RIIIS,J
R5975	T7701	T7699	pobj	J,for
R5976	T7702	T7701	punct	/,J
R5977	T7703	T7704	punct	(,mice
R5978	T7704	T7701	parataxis	mice,J
R5979	T7705	T7704	nummod	7,mice
R598	T771	T772	punct	-,0.3
R5980	T7706	T7704	punct	),mice
R5981	T7707	T7686	punct	.,analyzed
R5982	T7709	T7710	nsubj	Mice,were
R5983	T7711	T7709	prep	of,Mice
R5984	T7712	T7713	amod	most,strains
R5985	T7713	T7711	pobj	strains,of
R5986	T7714	T7715	quantmod	6,12
R5987	T7715	T7717	nummod	12,months
R5988	T7716	T7715	quantmod	to,12
R5989	T7717	T7718	npadvmod	months,old
R599	T772	T773	nummod	0.3,mmHg
R5990	T7718	T7710	acomp	old,were
R5991	T7719	T7710	punct	", ",were
R5992	T7720	T7710	prep	except,were
R5993	T7721	T7720	prep	for,except
R5994	T7722	T7723	compound	SEC,1ReJ
R5995	T7723	T7721	pobj	1ReJ,for
R5996	T7724	T7723	punct	/,1ReJ
R5997	T7725	T7723	cc	and,1ReJ
R5998	T7726	T7727	compound	SB,Le
R5999	T7727	T7723	conj	Le,1ReJ
R6	T35	T32	pobj	mice,in
R60	T96	T95	prep	in,IOP
R600	T773	T770	pobj	mmHg,of
R6000	T7728	T7727	punct	/,Le
R6001	T7729	T7730	dep	that,were
R6002	T7730	T7723	relcl	were,1ReJ
R6003	T7731	T7732	quantmod	2,3
R6004	T7732	T7734	nummod	3,months
R6005	T7733	T7732	quantmod	to,3
R6006	T7734	T7735	npadvmod	months,old
R6007	T7735	T7730	acomp	old,were
R6008	T7736	T7710	punct	.,were
R6009	T7738	T7739	advmod	Approximately,half
R601	T774	T768	punct	", ",mode
R6010	T7739	T7740	nsubj	half,were
R6011	T7741	T7739	prep	of,half
R6012	T7742	T7743	det	the,J
R6013	T7743	T7741	pobj	J,of
R6014	T7744	T7743	compound	CE,J
R6015	T7745	T7743	punct	/,J
R6016	T7746	T7739	cc	and,half
R6017	T7747	T7748	nummod	one,mice
R6018	T7748	T7739	conj	mice,half
R6019	T7749	T7747	quantmod	third,one
R602	T775	T776	punct	-,0.5
R6020	T7750	T7747	prep	of,one
R6021	T7751	T7752	det	the,BnJ
R6022	T7752	T7750	pobj	BnJ,of
R6023	T7753	T7752	compound	BUB,BnJ
R6024	T7754	T7752	punct	/,BnJ
R6025	T7755	T7756	nummod	16,months
R6026	T7756	T7757	npadvmod	months,old
R6027	T7757	T7740	acomp	old,were
R6028	T7758	T7740	cc	and,were
R6029	T7759	T7760	auxpass	were,pooled
R603	T776	T777	nummod	0.5,mmHg
R6030	T7760	T7740	conj	pooled,were
R6031	T7761	T7760	prep	with,pooled
R6032	T7762	T7763	det	the,mice
R6033	T7763	T7761	pobj	mice,with
R6034	T7764	T7763	amod	younger,mice
R6035	T7765	T7740	punct	", ",were
R6036	T7766	T7767	mark	as,were
R6037	T7767	T7740	advcl	were,were
R6038	T7768	T7769	det	the,IOPs
R6039	T7769	T7767	nsubj	IOPs,were
R604	T777	T768	appos	mmHg,mode
R6040	T7770	T7769	prep	of,IOPs
R6041	T7771	T7772	det	both,ages
R6042	T7772	T7770	pobj	ages,of
R6043	T7773	T7774	advmod	the,same
R6044	T7774	T7767	acomp	same,were
R6045	T7775	T7740	punct	.,were
R6046	T7777	T7778	compound	Strain,J
R6047	T7778	T7786	nsubjpass	J,abbreviated
R6048	T7779	T7778	compound	name,J
R6049	T7780	T7781	compound	CBA,CaHN
R605	T778	T768	punct	),mode
R6050	T7781	T7778	compound	CaHN,J
R6051	T7782	T7781	punct	/,CaHN
R6052	T7783	T7778	punct	-,J
R6053	T7784	T7778	compound	Btkxid,J
R6054	T7785	T7778	punct	/,J
R6055	T7787	T7786	auxpass	is,abbreviated
R6056	T7788	T7786	prep	to,abbreviated
R6057	T7789	T7790	compound	CBA,CaHN
R6058	T7790	T7788	pobj	CaHN,to
R6059	T7791	T7790	punct	/,CaHN
R606	T779	T752	cc	and,demonstrated
R6060	T7792	T7786	punct	.,abbreviated
R6061	T7816	T7817	amod	Normal,angles
R6062	T7818	T7817	amod	iridocorneal,angles
R6063	T7819	T7817	prep	in,angles
R6064	T7820	T7819	pobj	strains,in
R6065	T7821	T7820	prep	with,strains
R6066	T7822	T7823	amod	high,IOP
R6067	T7823	T7821	pobj	IOP,with
R6068	T7824	T7822	cc	and,high
R6069	T7825	T7822	conj	low,high
R607	T780	T752	conj	demonstrated,demonstrated
R6070	T7826	T7817	punct	.,angles
R6071	T7828	T7829	det	The,angle
R6072	T7829	T7831	nsubj	angle,had
R6073	T7830	T7829	amod	iridocorneal,angle
R6074	T7832	T7833	dep	that,contains
R6075	T7833	T7829	relcl	contains,angle
R6076	T7834	T7835	det	the,structures
R6077	T7835	T7833	dobj	structures,contains
R6078	T7836	T7837	amod	aqueous,humor
R6079	T7837	T7835	compound	humor,structures
R608	T781	T782	amod	significant,differences
R6080	T7838	T7835	compound	drainage,structures
R6081	T7839	T7835	punct	(,structures
R6082	T7840	T7841	poss	Schlemm,canal
R6083	T7841	T7835	appos	canal,structures
R6084	T7842	T7840	case	's,Schlemm
R6085	T7843	T7841	punct	(,canal
R6086	T7844	T7841	appos	SC,canal
R6087	T7845	T7841	punct	),canal
R6088	T7846	T7841	cc	and,canal
R6089	T7847	T7848	amod	trabecular,meshwork
R609	T782	T780	dobj	differences,demonstrated
R6090	T7848	T7841	conj	meshwork,canal
R6091	T7849	T7848	punct	(,meshwork
R6092	T7850	T7848	appos	TM,meshwork
R6093	T7851	T7831	punct	),had
R6094	T7852	T7853	det	a,morphology
R6095	T7853	T7831	dobj	morphology,had
R6096	T7854	T7853	amod	normal,morphology
R6097	T7855	T7831	prep	in,had
R6098	T7856	T7857	compound	strains,CaJ
R6099	T7857	T7855	pobj	CaJ,in
R61	T97	T98	amod	specific,backgrounds
R610	T783	T782	prep	in,differences
R6100	T7858	T7857	compound	CBA,CaJ
R6101	T7859	T7857	punct	/,CaJ
R6102	T7860	T7861	punct	(,IOP
R6103	T7861	T7857	parataxis	IOP,CaJ
R6104	T7862	T7861	dep	A,IOP
R6105	T7863	T7861	punct	", ",IOP
R6106	T7864	T7861	amod	high,IOP
R6107	T7865	T7861	punct	),IOP
R6108	T7866	T7857	punct	", ",CaJ
R6109	T7867	T7868	compound	BALB,cJ
R611	T784	T785	amod	intraocular,levels
R6110	T7868	T7857	appos	cJ,CaJ
R6111	T7869	T7868	punct	/,cJ
R6112	T7870	T7871	punct	(,IOP
R6113	T7871	T7868	parataxis	IOP,cJ
R6114	T7872	T7871	dep	B,IOP
R6115	T7873	T7871	punct	", ",IOP
R6116	T7874	T7871	amod	low,IOP
R6117	T7875	T7871	punct	),IOP
R6118	T7876	T7857	cc	and,CaJ
R6119	T7877	T7878	det	all,strains
R612	T785	T783	pobj	levels,in
R6120	T7878	T7857	conj	strains,CaJ
R6121	T7879	T7878	amod	other,strains
R6122	T7880	T7831	punct	.,had
R6123	T7882	T7883	npadvmod	Pigment,filled
R6124	T7883	T7884	amod	filled,macrophages
R6125	T7884	T7885	nsubjpass	macrophages,located
R6126	T7886	T7887	dep	that,resemble
R6127	T7887	T7884	relcl	resemble,macrophages
R6128	T7888	T7889	amod	human,cells
R6129	T7889	T7887	dobj	cells,resemble
R613	T786	T785	compound	pressure,levels
R6130	T7890	T7889	compound	clump,cells
R6131	T7891	T7885	auxpass	were,located
R6132	T7892	T7885	advmod	often,located
R6133	T7893	T7885	prep	in,located
R6134	T7894	T7895	det	the,angle
R6135	T7895	T7893	pobj	angle,in
R6136	T7896	T7895	prep	of,angle
R6137	T7897	T7898	compound	CBA,CaJ
R6138	T7898	T7900	compound	CaJ,mice
R6139	T7899	T7898	punct	/,CaJ
R614	T787	T782	prep	between,differences
R6140	T7900	T7896	pobj	mice,of
R6141	T7901	T7885	cc	but,located
R6142	T7902	T7885	conj	were,located
R6143	T7903	T7902	neg	never,were
R6144	T7904	T7902	acomp	sufficient,were
R6145	T7905	T7906	aux	to,block
R6146	T7906	T7904	xcomp	block,sufficient
R6147	T7907	T7906	dobj	drainage,block
R6148	T7908	T7885	punct	.,located
R6149	T7910	T7911	nsubj	We,observed
R615	T788	T789	nummod	four,strains
R6150	T7912	T7911	aux	have,observed
R6151	T7913	T7914	amod	similar,quantities
R6152	T7914	T7911	dobj	quantities,observed
R6153	T7915	T7914	prep	of,quantities
R6154	T7916	T7917	det	these,cells
R6155	T7917	T7915	pobj	cells,of
R6156	T7918	T7914	prep	at,quantities
R6157	T7919	T7920	det	this,location
R6158	T7920	T7918	pobj	location,at
R6159	T7921	T7911	prep	in,observed
R616	T789	T787	pobj	strains,between
R6160	T7922	T7923	amod	other,strains
R6161	T7923	T7921	pobj	strains,in
R6162	T7924	T7923	prep	with,strains
R6163	T7925	T7926	amod	lower,IOP
R6164	T7926	T7924	pobj	IOP,with
R6165	T7927	T7911	punct	.,observed
R6166	T7929	T7930	det	The,recess
R6167	T7930	T7932	nsubj	recess,was
R6168	T7931	T7930	amod	angle,recess
R6169	T7933	T7930	prep	between,recess
R617	T790	T789	compound	mouse,strains
R6170	T7934	T7935	det	the,cornea
R6171	T7935	T7933	pobj	cornea,between
R6172	T7936	T7935	punct	(,cornea
R6173	T7937	T7935	appos	C,cornea
R6174	T7938	T7935	punct	),cornea
R6175	T7939	T7935	cc	and,cornea
R6176	T7940	T7941	compound	iris,root
R6177	T7941	T7935	conj	root,cornea
R6178	T7942	T7941	punct	(,root
R6179	T7943	T7957	punct	.,passes
R618	T791	T752	punct	.,demonstrated
R6180	T7945	T7941	appos	I,root
R6181	T7946	T7932	punct	),was
R6182	T7947	T7948	amod	Original,Magnification
R6183	T7948	T7966	compound	Magnification,630X
R6184	T7949	T7932	acomp	open,was
R6185	T7950	T7949	cc	and,open
R6186	T7951	T7952	neg	not,occluded
R6187	T7952	T7949	conj	occluded,open
R6188	T7953	T7932	punct	.,was
R6189	T7955	T7956	amod	Aqueous,humor
R619	T793	T794	advmod	Here,provide
R6190	T7956	T7957	nsubj	humor,passes
R6191	T7958	T7957	prep	through,passes
R6192	T7959	T7960	det	this,recess
R6193	T7960	T7958	pobj	recess,through
R6194	T7961	T7957	prep	before,passes
R6195	T7962	T7961	pcomp	entering,before
R6196	T7963	T7964	det	the,structures
R6197	T7964	T7962	dobj	structures,entering
R6198	T7965	T7964	compound	drainage,structures
R6199	T7967	T7966	punct	.,630X
R62	T98	T96	pobj	backgrounds,in
R620	T795	T794	punct	", ",provide
R6200	T8009	T8010	det	The,IOPs
R6201	T8010	T8011	nsubj	IOPs,are
R6202	T8012	T8010	prep	of,IOPs
R6203	T8013	T8014	amod	different,strains
R6204	T8014	T8012	pobj	strains,of
R6205	T8015	T8011	acomp	stable,are
R6206	T8016	T8015	cc	and,stable
R6207	T8017	T8015	conj	reproducible,stable
R6208	T8018	T8011	prep	over,are
R6209	T8019	T8018	pobj	time,over
R621	T796	T794	nsubj	we,provide
R6210	T8020	T8011	punct	.,are
R6211	T8022	T8023	compound	Mean,IOP
R6212	T8023	T8024	nsubjpass	IOP,shown
R6213	T8025	T8023	punct	±,IOP
R6214	T8026	T8023	appos	SEM,IOP
R6215	T8027	T8024	auxpass	is,shown
R6216	T8028	T8024	prep	for,shown
R6217	T8029	T8030	det	the,strain
R6218	T8030	T8028	pobj	strain,for
R6219	T8031	T8030	amod	indicated,strain
R622	T797	T798	det	an,update
R6220	T8032	T8024	prep	at,shown
R6221	T8033	T8034	amod	different,times
R6222	T8034	T8032	pobj	times,at
R6223	T8035	T8034	prep	of,times
R6224	T8036	T8035	pobj	measurement,of
R6225	T8037	T8024	punct	.,shown
R6226	T8039	T8040	det	The,times
R6227	T8040	T8042	nsubjpass	times,separated
R6228	T8041	T8040	compound	measurement,times
R6229	T8043	T8040	prep	within,times
R623	T798	T794	dobj	update,provide
R6230	T8044	T8045	det	a,year
R6231	T8045	T8043	pobj	year,within
R6232	T8046	T8045	amod	single,year
R6233	T8047	T8042	auxpass	were,separated
R6234	T8048	T8042	agent	by,separated
R6235	T8049	T8050	det	a,months
R6236	T8050	T8048	pobj	months,by
R6237	T8051	T8050	amod	few,months
R6238	T8052	T8042	punct	.,separated
R6239	T8054	T8055	det	The,IOPs
R624	T799	T798	punct	", ",update
R6240	T8055	T8056	nsubjpass	IOPs,listed
R6241	T8057	T8055	prep	of,IOPs
R6242	T8058	T8057	pobj	strains,of
R6243	T8059	T8060	dep	that,analyzed
R6244	T8060	T8058	relcl	analyzed,strains
R6245	T8061	T8060	auxpass	were,analyzed
R6246	T8062	T8063	amod	multiple,times
R6247	T8063	T8060	npadvmod	times,analyzed
R6248	T8064	T8060	prep	in,analyzed
R6249	T8065	T8066	det	the,year
R625	T800	T798	prep	including,update
R6250	T8066	T8064	pobj	year,in
R6251	T8067	T8066	amod	same,year
R6252	T8068	T8056	auxpass	are,listed
R6253	T8069	T8056	prep	in,listed
R6254	T8070	T8071	det	the,order
R6255	T8071	T8069	pobj	order,in
R6256	T8072	T8071	amod	chronological,order
R6257	T8073	T8080	det	the,measurement
R6258	T8074	T8075	prep	that,obtained
R6259	T8075	T8071	relcl	obtained,order
R626	T801	T802	det	an,survey
R6260	T8076	T8075	nsubjpass	they,obtained
R6261	T8077	T8075	auxpass	were,obtained
R6262	T8078	T8079	mark	with,on
R6263	T8079	T8056	advcl	on,listed
R6264	T8080	T8079	nsubj	measurement,on
R6265	T8081	T8107	punct	(,number
R6266	T8082	T8080	amod	earliest,measurement
R6267	T8083	T8079	pobj	left,on
R6268	T8084	T8056	punct	.,listed
R6269	T8086	T8087	det	The,sex
R627	T802	T800	pobj	survey,including
R6270	T8087	T8088	nsubjpass	sex,listed
R6271	T8089	T8087	punct	[,sex
R6272	T8090	T8087	appos	Male,sex
R6273	T8091	T8090	punct	(,Male
R6274	T8092	T8090	appos	M,Male
R6275	T8093	T8090	punct	),Male
R6276	T8094	T8090	cc	or,Male
R6277	T8095	T8090	conj	Female,Male
R6278	T8096	T8095	punct	(,Female
R6279	T8097	T8095	appos	F,Female
R628	T803	T802	amod	extensive,survey
R6280	T8098	T8087	punct	),sex
R6281	T8099	T8087	punct	],sex
R6282	T8100	T8087	punct	", ",sex
R6283	T8101	T8087	conj	age,sex
R6284	T8102	T8101	punct	(,age
R6285	T8103	T8101	appos	months,age
R6286	T8104	T8101	punct	),age
R6287	T8105	T8101	punct	", ",age
R6288	T8106	T8101	cc	and,age
R6289	T8107	T8101	conj	number,age
R629	T804	T802	compound	strain,survey
R6290	T8108	T8107	prep	of,number
R6291	T8109	T8108	pobj	mice,of
R6292	T8110	T8107	appos	n,number
R6293	T8111	T8087	punct	),sex
R6294	T8112	T8087	acl	analyzed,sex
R6295	T8113	T8112	prep	for,analyzed
R6296	T8114	T8115	det	the,strains
R6297	T8115	T8113	pobj	strains,for
R6298	T8116	T8115	compound	CBA,strains
R6299	T8117	T8088	auxpass	are,listed
R63	T99	T98	compound	strain,backgrounds
R630	T805	T794	punct	", ",provide
R6300	T8118	T8088	advcl	starting,listed
R6301	T8119	T8118	prep	with,starting
R6302	T8120	T8121	det	the,measurement
R6303	T8121	T8119	pobj	measurement,with
R6304	T8122	T8121	amod	earliest,measurement
R6305	T8123	T8118	cc	and,starting
R6306	T8124	T8118	conj	ending,starting
R6307	T8125	T8124	prep	with,ending
R6308	T8126	T8127	det	the,latest
R6309	T8127	T8125	pobj	latest,with
R631	T806	T794	cc	and,provide
R6310	T8128	T8088	punct	: ,listed
R6311	T8129	T8130	compound	CBA,CaJ
R6312	T8130	T8132	dep	CaJ,CaHN
R6313	T8131	T8130	punct	/,CaJ
R6314	T8132	T8088	dep	CaHN,listed
R6315	T8133	T8130	punct	", ",CaJ
R6316	T8134	T8135	dep	F,22
R6317	T8135	T8130	dep	22,CaJ
R6318	T8136	T8135	punct	", ",22
R6319	T8137	T8135	nsubj	n,22
R632	T807	T794	conj	show,provide
R6320	T8138	T8135	punct	=,22
R6321	T8139	T8135	punct	", ",22
R6322	T8140	T8135	dep	age,22
R6323	T8141	T8140	appos	6,age
R6324	T8142	T8143	punct	–,7
R6325	T8143	T8141	prep	7,6
R6326	T8144	T8130	punct	;,CaJ
R6327	T8145	T8146	dep	M,11
R6328	T8146	T8130	dep	11,CaJ
R6329	T8147	T8146	punct	", ",11
R633	T808	T809	mark	that,is
R6330	T8148	T8146	nsubj	n,11
R6331	T8149	T8146	punct	=,11
R6332	T8150	T8146	punct	", ",11
R6333	T8151	T8146	dep	age,11
R6334	T8152	T8151	nummod	2,age
R6335	T8153	T8132	punct	;,CaHN
R6336	T8154	T8132	compound	CBA,CaHN
R6337	T8155	T8132	punct	/,CaHN
R6338	T8156	T8132	punct	", ",CaHN
R6339	T8157	T8158	dep	F,16
R634	T809	T807	ccomp	is,show
R6340	T8158	T8132	dep	16,CaHN
R6341	T8159	T8158	punct	", ",16
R6342	T8160	T8158	nsubj	n,16
R6343	T8161	T8158	punct	=,16
R6344	T8162	T8158	punct	", ",16
R6345	T8163	T8158	dep	age,16
R6346	T8164	T8163	nummod	3,age
R6347	T8165	T8132	punct	;,CaHN
R6348	T8166	T8167	dep	M,8
R6349	T8167	T8132	dep	8,CaHN
R635	T810	T811	det	the,methodology
R6350	T8168	T8167	punct	", ",8
R6351	T8169	T8167	nsubj	n,8
R6352	T8170	T8167	punct	=,8
R6353	T8171	T8167	punct	", ",8
R6354	T8172	T8167	dep	age,8
R6355	T8173	T8172	nummod	3,age
R6356	T8174	T8132	punct	.,CaHN
R6357	T8176	T8177	prep	For,were
R6358	T8178	T8179	compound	BALB,cJ
R6359	T8179	T8176	pobj	cJ,For
R636	T811	T809	nsubj	methodology,is
R6360	T8180	T8179	punct	/,cJ
R6361	T8181	T8179	cc	and,cJ
R6362	T8182	T8184	compound	C57BL,6J
R6363	T8183	T8189	conj	old,male
R6364	T8184	T8179	conj	6J,cJ
R6365	T8185	T8184	punct	/,6J
R6366	T8186	T8177	punct	", ",were
R6367	T8187	T8188	det	all,groups
R6368	T8188	T8177	nsubj	groups,were
R6369	T8189	T8177	acomp	male,were
R637	T812	T809	acomp	reliable,is
R6370	T8190	T8189	cc	and,male
R6371	T8191	T8183	advmod	primarily,old
R6372	T8192	T8193	quantmod	3,4
R6373	T8193	T8195	nummod	4,months
R6374	T8194	T8193	quantmod	to,4
R6375	T8195	T8183	npadvmod	months,old
R6376	T8196	T8177	punct	.,were
R6377	T8198	T8199	det	The,number
R6378	T8199	T8200	nsubj	number,follows
R6379	T8201	T8199	prep	of,number
R638	T813	T809	cc	and,is
R6380	T8202	T8201	pobj	mice,of
R6381	T8203	T8199	acl	analyzed,number
R6382	T8204	T8203	prep	at,analyzed
R6383	T8205	T8206	det	each,time
R6384	T8206	T8204	pobj	time,at
R6385	T8207	T8200	punct	: ,follows
R6386	T8208	T8209	compound	BALB,cJ
R6387	T8209	T8211	dep	cJ,8
R6388	T8210	T8209	punct	/,cJ
R6389	T8211	T8212	dep	8,10
R639	T814	T809	conj	produces,is
R6390	T8212	T8200	dep	10,follows
R6391	T8213	T8211	punct	", ",8
R6392	T8214	T8211	conj	10,8
R6393	T8215	T8214	punct	", ",10
R6394	T8216	T8214	conj	11,10
R6395	T8217	T8216	punct	", ",11
R6396	T8218	T8216	conj	15,11
R6397	T8219	T8218	punct	", ",15
R6398	T8220	T8218	conj	18,15
R6399	T8221	T8220	cc	and,18
R64	T100	T71	punct	", ",determine
R640	T815	T816	amod	reproducible,data
R6400	T8222	T8220	conj	14,18
R6401	T8223	T8212	punct	", ",10
R6402	T8224	T8225	compound	C57BL,6J
R6403	T8225	T8212	dep	6J,10
R6404	T8226	T8225	punct	/,6J
R6405	T8227	T8212	punct	", ",10
R6406	T8228	T8212	conj	14,10
R6407	T8229	T8228	punct	", ",14
R6408	T8230	T8228	conj	21,14
R6409	T8231	T8230	punct	",",21
R641	T816	T814	dobj	data,produces
R6410	T8232	T8230	conj	40,21
R6411	T8233	T8232	punct	",",40
R6412	T8234	T8232	conj	40,40
R6413	T8235	T8234	cc	and,40
R6414	T8236	T8234	conj	42,40
R6415	T8237	T8212	punct	.,10
R6416	T8239	T8240	compound	Strain,J
R6417	T8240	T8248	nsubjpass	J,abbreviated
R6418	T8241	T8240	compound	name,J
R6419	T8242	T8243	compound	CBA,CaHN
R642	T817	T814	prep	over,produces
R6420	T8243	T8240	compound	CaHN,J
R6421	T8244	T8243	punct	/,CaHN
R6422	T8245	T8240	punct	-,J
R6423	T8246	T8240	compound	Btkxid,J
R6424	T8247	T8240	punct	/,J
R6425	T8249	T8248	auxpass	is,abbreviated
R6426	T8250	T8248	prep	to,abbreviated
R6427	T8251	T8252	compound	CBA,CaHN
R6428	T8252	T8250	pobj	CaHN,to
R6429	T8253	T8252	punct	/,CaHN
R643	T818	T819	amod	extended,periods
R6430	T8254	T8248	punct	.,abbreviated
R6431	T8266	T8267	compound	IOP,changes
R6432	T8268	T8267	prep	with,changes
R6433	T8269	T8270	amod	increasing,Age
R6434	T8270	T8268	pobj	Age,with
R6435	T8271	T8267	punct	.,changes
R6436	T8273	T8274	compound	Mean,IOP
R6437	T8274	T8275	nsubjpass	IOP,shown
R6438	T8276	T8274	punct	±,IOP
R6439	T8277	T8274	appos	SEM,IOP
R644	T819	T817	pobj	periods,over
R6440	T8278	T8275	auxpass	is,shown
R6441	T8279	T8275	prep	for,shown
R6442	T8280	T8281	det	the,strain
R6443	T8281	T8279	pobj	strain,for
R6444	T8282	T8281	amod	indicated,strain
R6445	T8283	T8275	prep	at,shown
R6446	T8284	T8285	amod	different,ages
R6447	T8285	T8283	pobj	ages,at
R6448	T8286	T8275	punct	.,shown
R6449	T8288	T8289	nsubj	IOP,decreased
R645	T820	T819	prep	of,periods
R6450	T8290	T8289	advmod	significantly,decreased
R6451	T8291	T8289	prep	in,decreased
R6452	T8292	T8293	compound	strains,6J
R6453	T8293	T8291	pobj	6J,in
R6454	T8294	T8293	compound	C57BL,6J
R6455	T8295	T8293	punct	/,6J
R6456	T8296	T8293	cc	and,6J
R6457	T8297	T8298	compound	129P3,J
R6458	T8298	T8293	conj	J,6J
R6459	T8299	T8298	punct	/,J
R646	T821	T820	pobj	time,of
R6460	T8300	T8293	cc	but,6J
R6461	T8301	T8300	neg	not,but
R6462	T8302	T8303	compound	C3H,HeJ
R6463	T8303	T8293	conj	HeJ,6J
R6464	T8304	T8303	punct	/,HeJ
R6465	T8305	T8289	punct	.,decreased
R6466	T8307	T8308	det	The,groups
R6467	T8308	T8316	nsubj	groups,consisted
R6468	T8309	T8310	nmod	C57BL,6J
R6469	T8310	T8308	nmod	6J,groups
R647	T822	T794	punct	.,provide
R6470	T8311	T8310	punct	/,6J
R6471	T8312	T8310	cc	and,6J
R6472	T8313	T8314	compound	129P3,J
R6473	T8314	T8310	conj	J,6J
R6474	T8315	T8314	punct	/,J
R6475	T8317	T8316	prep	of,consisted
R6476	T8318	T8319	advmod	approximately,equal
R6477	T8319	T8320	amod	equal,numbers
R6478	T8320	T8317	pobj	numbers,of
R6479	T8321	T8320	prep	of,numbers
R648	T894	T895	det	A,range
R6480	T8322	T8321	pobj	males,of
R6481	T8323	T8322	cc	and,males
R6482	T8324	T8322	conj	females,males
R6483	T8325	T8316	punct	.,consisted
R6484	T8327	T8328	det	The,mice
R6485	T8328	T8335	nsubj	mice,were
R6486	T8329	T8330	nummod	3,months
R6487	T8330	T8331	npadvmod	months,old
R6488	T8331	T8328	amod	old,mice
R6489	T8332	T8333	compound	C3H,HeJ
R649	T896	T895	amod	broad,range
R6490	T8333	T8328	compound	HeJ,mice
R6491	T8334	T8333	punct	/,HeJ
R6492	T8336	T8335	acomp	male,were
R6493	T8337	T8338	mark	while,composed
R6494	T8338	T8335	advcl	composed,were
R6495	T8339	T8340	det	the,ages
R6496	T8340	T8338	nsubjpass	ages,composed
R6497	T8341	T8340	amod	other,ages
R6498	T8342	T8338	auxpass	were,composed
R6499	T8343	T8338	prep	of,composed
R65	T101	T71	cc	and,determine
R650	T897	T895	prep	of,range
R6500	T8344	T8343	pobj	males,of
R6501	T8345	T8344	cc	and,males
R6502	T8346	T8344	conj	females,males
R6503	T8347	T8335	punct	.,were
R6504	T8349	T8350	det	The,number
R6505	T8350	T8351	nsubj	number,follow
R6506	T8352	T8350	prep	of,number
R6507	T8353	T8352	pobj	mice,of
R6508	T8354	T8350	acl	analyzed,number
R6509	T8355	T8354	prep	at,analyzed
R651	T898	T897	pobj	IOPs,of
R6510	T8356	T8357	det	each,age
R6511	T8357	T8355	pobj	age,at
R6512	T8358	T8350	punct	", ",number
R6513	T8359	T8350	acl	listed,number
R6514	T8360	T8359	prep	from,listed
R6515	T8361	T8360	pobj	youngest,from
R6516	T8362	T8360	prep	to,from
R6517	T8363	T8362	pobj	oldest,to
R6518	T8364	T8351	punct	", ",follow
R6519	T8365	T8351	punct	: ,follow
R652	T899	T895	prep	between,range
R6520	T8366	T8367	compound	C57BL,6J
R6521	T8367	T8369	dep	6J,13
R6522	T8368	T8367	punct	/,6J
R6523	T8369	T8379	dep	13,15
R6524	T8370	T8369	punct	", ",13
R6525	T8371	T8369	nummod	18,13
R6526	T8372	T8369	punct	", ",13
R6527	T8373	T8369	nummod	18,13
R6528	T8374	T8369	punct	", ",13
R6529	T8375	T8369	nummod	18,13
R653	T900	T899	pobj	strains,between
R6530	T8376	T8369	punct	", ",13
R6531	T8377	T8369	nummod	18,13
R6532	T8378	T8369	punct	", ",13
R6533	T8379	T8351	dep	15,follow
R6534	T8380	T8379	punct	;,15
R6535	T8381	T8382	compound	129P3,J
R6536	T8382	T8384	dep	J,21
R6537	T8383	T8382	punct	/,J
R6538	T8384	T8379	dep	21,15
R6539	T8385	T8384	punct	", ",21
R654	T902	T903	nsubj	Figure,shows
R6540	T8386	T8384	nummod	18,21
R6541	T8387	T8384	punct	", ",21
R6542	T8388	T8384	nummod	15,21
R6543	T8389	T8384	punct	", ",21
R6544	T8390	T8384	nummod	16,21
R6545	T8391	T8384	punct	", ",21
R6546	T8392	T8384	nummod	14,21
R6547	T8393	T8384	punct	", ",21
R6548	T8394	T8379	punct	;,15
R6549	T8395	T8396	compound	C3H,HeJ
R655	T904	T902	nummod	1,Figure
R6550	T8396	T8379	dep	HeJ,15
R6551	T8397	T8396	punct	/,HeJ
R6552	T8398	T8379	punct	", ",15
R6553	T8399	T8379	punct	", ",15
R6554	T8400	T8401	nummod	23,17
R6555	T8401	T8379	conj	17,15
R6556	T8402	T8401	cc	and,17
R6557	T8403	T8401	conj	16,17
R6558	T8404	T8379	punct	.,15
R6559	T8421	T8422	det	No,effect
R656	T905	T906	det	the,IOP
R6560	T8423	T8422	prep	of,effect
R6561	T8424	T8425	nmod	1X,dose
R6562	T8425	T8423	pobj	dose,of
R6563	T8426	T8424	amod	anesthetic,1X
R6564	T8427	T8422	prep	within,effect
R6565	T8428	T8429	nummod	12,minutes
R6566	T8429	T8427	pobj	minutes,within
R6567	T8430	T8429	prep	of,minutes
R6568	T8431	T8430	pobj	administration,of
R6569	T8432	T8422	punct	.,effect
R657	T906	T903	dobj	IOP,shows
R6570	T8434	T8435	det	A,IOP
R6571	T8435	T8437	nsubjpass	IOP,shown
R6572	T8436	T8435	compound	Mean,IOP
R6573	T8438	T8435	punct	±,IOP
R6574	T8439	T8435	appos	SD,IOP
R6575	T8440	T8437	auxpass	is,shown
R6576	T8441	T8437	prep	for,shown
R6577	T8442	T8443	compound	C57BL,6J
R6578	T8443	T8445	compound	6J,mice
R6579	T8444	T8443	punct	/,6J
R658	T907	T906	amod	average,IOP
R6580	T8445	T8441	pobj	mice,for
R6581	T8446	T8437	prep	at,shown
R6582	T8447	T8448	nummod	5,minutes
R6583	T8448	T8446	pobj	minutes,at
R6584	T8449	T8447	cc	and,5
R6585	T8450	T8447	conj	25,5
R6586	T8451	T8448	prep	after,minutes
R6587	T8452	T8451	pobj	administration,after
R6588	T8453	T8452	prep	of,administration
R6589	T8454	T8455	amod	various,doses
R659	T908	T906	prep	of,IOP
R6590	T8455	T8453	pobj	doses,of
R6591	T8456	T8455	prep	of,doses
R6592	T8457	T8456	pobj	anesthetic,of
R6593	T8458	T8437	punct	.,shown
R6594	T8460	T8461	det	The,dose
R6595	T8461	T8463	nsubj	dose,consisted
R6596	T8462	T8461	compound	1X,dose
R6597	T8464	T8463	prep	of,consisted
R6598	T8465	T8466	nummod	99,mg
R6599	T8466	T8467	nmod	mg,ketamine
R66	T102	T103	aux	to,assess
R660	T909	T910	det	a,number
R6600	T8467	T8464	pobj	ketamine,of
R6601	T8468	T8469	punct	/,kg
R6602	T8469	T8466	prep	kg,mg
R6603	T8470	T8467	cc	and,ketamine
R6604	T8471	T8472	nummod	9,mg
R6605	T8472	T8473	nmod	mg,xylazine
R6606	T8473	T8467	conj	xylazine,ketamine
R6607	T8474	T8475	punct	/,kg
R6608	T8475	T8472	prep	kg,mg
R6609	T8476	T8463	punct	.,consisted
R661	T910	T908	pobj	number,of
R6610	T8478	T8479	det	All,doses
R6611	T8479	T8480	nsubj	doses,decreased
R6612	T8481	T8480	dobj	IOP,decreased
R6613	T8482	T8480	prep	by,decreased
R6614	T8483	T8484	nummod	25,minutes
R6615	T8484	T8482	pobj	minutes,by
R6616	T8485	T8480	punct	.,decreased
R6617	T8487	T8488	prep	At,was
R6618	T8489	T8490	det	all,doses
R6619	T8490	T8487	pobj	doses,At
R662	T911	T910	prep	of,number
R6620	T8491	T8492	det	the,IOP
R6621	T8492	T8488	nsubj	IOP,was
R6622	T8493	T8492	prep	at,IOP
R6623	T8494	T8495	nummod	5,minutes
R6624	T8495	T8493	pobj	minutes,at
R6625	T8496	T8497	advmod	the,same
R6626	T8497	T8488	acomp	same,was
R6627	T8498	T8488	advcl	suggesting,was
R6628	T8499	T8500	mark	that,occurred
R6629	T8500	T8498	ccomp	occurred,suggesting
R663	T912	T913	amod	inbred,strains
R6630	T8501	T8502	det	the,effect
R6631	T8502	T8500	nsubj	effect,occurred
R6632	T8503	T8502	prep	of,effect
R6633	T8504	T8503	pobj	anesthesia,of
R6634	T8505	T8500	aux	had,occurred
R6635	T8506	T8500	neg	not,occurred
R6636	T8507	T8500	advmod	yet,occurred
R6637	T8508	T8488	punct	.,was
R6638	T8510	T8511	advmod	Approximately,thirty
R6639	T8511	T8512	nummod	thirty,mice
R664	T913	T911	pobj	strains,of
R6640	T8512	T8518	nsubjpass	mice,analyzed
R6641	T8513	T8514	quantmod	3,4
R6642	T8514	T8516	nummod	4,month
R6643	T8515	T8514	quantmod	to,4
R6644	T8516	T8517	npadvmod	month,old
R6645	T8517	T8512	amod	old,mice
R6646	T8519	T8518	auxpass	were,analyzed
R6647	T8520	T8518	prep	at,analyzed
R6648	T8521	T8522	det	each,dose
R6649	T8522	T8520	pobj	dose,at
R665	T914	T913	compound	mouse,strains
R6650	T8523	T8522	cc	and,dose
R6651	T8524	T8522	conj	time,dose
R6652	T8525	T8518	parataxis	B,analyzed
R6653	T8526	T8527	punct	-,D
R6654	T8527	T8525	prep	D,B
R6655	T8528	T8518	punct	.,analyzed
R6656	T8530	T8531	compound	Scatter,plots
R6657	T8531	T8533	nsubj	plots,demonstrating
R6658	T8532	T8531	punct	-,plots
R6659	T8534	T8535	det	no,change
R666	T915	T916	dep	that,housed
R6660	T8535	T8533	dobj	change,demonstrating
R6661	T8536	T8535	prep	in,change
R6662	T8537	T8536	pobj	IOP,in
R6663	T8538	T8533	prep	over,demonstrating
R6664	T8539	T8540	det	the,minutes
R6665	T8540	T8538	pobj	minutes,over
R6666	T8541	T8540	nummod	12,minutes
R6667	T8542	T8540	prep	following,minutes
R6668	T8543	T8544	compound	anesthetic,administration
R6669	T8544	T8542	pobj	administration,following
R667	T916	T910	relcl	housed,number
R6670	T8545	T8533	prep	in,demonstrating
R6671	T8546	T8547	nummod	three,strains
R6672	T8547	T8545	pobj	strains,in
R6673	T8548	T8549	advmod	relatively,unrelated
R6674	T8549	T8547	amod	unrelated,strains
R6675	T8550	T8547	compound	mouse,strains
R6676	T8551	T8533	punct	.,demonstrating
R6677	T8553	T8554	det	All,strains
R6678	T8554	T8555	nsubj	strains,consisted
R6679	T8556	T8555	prep	of,consisted
R668	T917	T916	auxpass	were,housed
R6680	T8557	T8556	pobj	males,of
R6681	T8558	T8557	cc	and,males
R6682	T8559	T8557	conj	females,males
R6683	T8560	T8561	dep	that,ranged
R6684	T8561	T8557	relcl	ranged,males
R6685	T8562	T8561	prep	from,ranged
R6686	T8563	T8562	pobj	3,from
R6687	T8564	T8562	prep	to,from
R6688	T8565	T8564	pobj	6,to
R6689	T8566	T8562	pobj	months,from
R669	T918	T916	prep	in,housed
R6690	T8567	T8566	prep	of,months
R6691	T8568	T8567	pobj	age,of
R6692	T8569	T8555	punct	.,consisted
R6693	T8571	T8572	det	The,sexes
R6694	T8572	T8573	nsubj	sexes,were
R6695	T8574	T8572	cc	and,sexes
R6696	T8575	T8572	conj	ages,sexes
R6697	T8576	T8577	advmod	equally,represented
R6698	T8577	T8573	acomp	represented,were
R6699	T8578	T8573	prep	at,were
R67	T103	T71	conj	assess,determine
R670	T919	T920	det	the,conditions
R6700	T8579	T8580	det	each,point
R6701	T8580	T8578	pobj	point,at
R6702	T8581	T8580	compound	time,point
R6703	T8582	T8573	punct	.,were
R6704	T8584	T8585	det	The,plots
R6705	T8585	T8588	nsubj	plots,include
R6706	T8586	T8585	compound	scatter,plots
R6707	T8587	T8585	punct	-,plots
R6708	T8589	T8590	nummod	195,6J
R6709	T8590	T8593	nmod	6J,mice
R671	T920	T918	pobj	conditions,in
R6710	T8591	T8590	nmod	C57BL,6J
R6711	T8592	T8590	punct	/,6J
R6712	T8593	T8588	dobj	mice,include
R6713	T8594	T8590	punct	", ",6J
R6714	T8595	T8596	nummod	161,J
R6715	T8596	T8590	conj	J,6J
R6716	T8597	T8596	compound	129P3,J
R6717	T8598	T8596	punct	/,J
R6718	T8599	T8596	cc	and,J
R6719	T8600	T8601	nummod	145,2J
R672	T921	T920	amod	same,conditions
R6720	T8601	T8596	conj	2J,J
R6721	T8602	T8601	compound	DBA,2J
R6722	T8603	T8601	punct	/,2J
R6723	T8604	T8588	punct	.,include
R6724	T8625	T8626	nsubjpass	IOP,increased
R6725	T8627	T8626	auxpass	is,increased
R6726	T8628	T8626	prep	during,increased
R6727	T8629	T8630	det	the,dark
R6728	T8630	T8628	pobj	dark,during
R6729	T8631	T8630	prep	compared,dark
R673	T922	T920	amod	environmental,conditions
R6730	T8632	T8631	prep	to,compared
R6731	T8633	T8632	pobj	light,to
R6732	T8634	T8630	appos	periods,dark
R6733	T8635	T8626	prep	in,increased
R6734	T8636	T8637	amod	several,strains
R6735	T8637	T8635	pobj	strains,in
R6736	T8638	T8626	punct	.,increased
R6737	T8640	T8641	compound	Mean,IOP
R6738	T8641	T8642	nsubjpass	IOP,shown
R6739	T8643	T8641	punct	±,IOP
R674	T923	T903	punct	.,shows
R6740	T8644	T8641	appos	SEM,IOP
R6741	T8645	T8642	auxpass	is,shown
R6742	T8646	T8642	prep	for,shown
R6743	T8647	T8648	det	the,"strain at different times of measurement. The measurement times within a single year were separated by a few months. The IOPs of strains that were analyzed multiple times in the same year are listed in the chronological order that they were obtained with the earliest measurement on left. The sex [Male (M) or Female (F)], age (months), and number of mice (n) analyzed for the CBA strains are listed starting with the earliest measurement and ending with the latest: CBA/CaJ, F, n = 22, age 6–7; M, n = 11, age 2; CBA/CaHN, F, n = 16, age 3; M, n = 8, age 3. For BALB/cJ and C57BL/6J, all groups were male and primarily 3 to 4 months old. The number of mice analyzed at each time follows: BALB/cJ 8, 10, 11, 15, 18 and 14, C57BL/6J 10, 14, 21,40,40 and 42. Strain name CBA/CaHN-Btkxid/J is abbreviated to CBA/CaHN. Despite the general consistency of IOP, the average IOPs of some strains have changed in a reproducible manner. The IOPs of BALB/cJ mice (low end of spectrum) were very similar for the past several years, around 11 mmHg. Between early 1996 and 1997, however, the IOP of this strain did jump from approximately 7.7 mmHg to approximately 11 mmHg (Figure 3). During this period, the room in which our animals were housed and the manufacturer of the mouse diet were changed. Over the same period, the IOP of A/J also increased dramatically, from 9.4 ± 0.5 mmHg (n = 11) in 1996 to 14.2 ± 0.4 mmHg (n = 19) in 1997. The increased IOP in A/J also was reproducible, with the average IOP of mice assessed in the year 2000 being 14.5 ± 0.4 mmHg (n = 16). Importantly, the IOPs of strains B6 and C3H/HeJ did not change during this time (B6, 12.3. ± 0.5 mmHg in 1996 and 12.4 ± 0.3 mmHg in 1997, n= 10 and 14; C3H/HeJ, 13.7 ± 0.8 mmHg in 1996 and 13.6 ± 0.2 mmHg in 1997, n = 9 and 19). Effect of age on IOP We focused on the commonly used B6, 129P3/J and C3H/HeJ strains to determine the effects of age on IOP (Figure 4). In B6, age had a significant effect on IOP (P < 0.001). IOP was slightly decreased at both 12 months (12.2 ± 0.2 mmHg) and 19 months (12.2 ± 0.3 mmHg) compared to 3 months (13.1 ± 0.3 mmHg) and 7 months (13.3 ± 0.3 mmHg). Although the decrease was of a similar level to the variation observed in 3 month old mice (see Figure 3), the IOPs of control young mice (see Methods) analyzed at the same times as the various B6 age groups did not decrease. For example, control mice analyzed at the same time as the 3 month, 12 month and 18 month B6 age groups had IOPs of 13.0 ± 0.2 mmHg (n = 14), 13.3 ± 0.2 mmHg (n = 14), 13.7 ± 0.4 mmHg (n = 12), respectively. IOP was even lower in the 24 month B6 mice (10.8 ± 0.4 mmHg), and again the average IOP of young controls measured at the same time was not changed (13.5 ± 0.2, n = 12). Figure 4 IOP changes with increasing Age. Mean IOP ± SEM is shown for the indicated strain at different ages. IOP decreased significantly in strains C57BL/6J and 129P3/J but not C3H/HeJ. The C57BL/6J and 129P3/J groups consisted of approximately equal numbers of males and females. The 3 months old C3H/HeJ mice were male while the other ages were composed of males and females. The number of mice analyzed at each age, listed from youngest to oldest, follow: C57BL/6J, 18, 18, 18, 18, 13; 129P3/J, 18, 15, 16, 14, 21; C3H/HeJ, 15, 23 17 and 16. In strain 129P3/J, IOP did not differ significantly with age between 3 and 14 months but was lower in 18 month old mice (P < 0.001 compared to all younger ages, Figure 4). Despite a 1 mmHg dip in IOP at 8 months, there were no significant IOP differences between C3H/HeJ mice at each age tested (P = 0.2 for age). Although the effect of age has not been thoroughly assessed in other strains, no obvious age-related differences have been identified in other strains analyzed at multiple ages except for the glaucomatous DBA/2J and AKXD-28/Ty strains [14,19]. Effect of sex on IOP Although we have not rigorously assessed the effect of sex on IOP in many strains, sex specific differences have not been detected in the majority of strains for which both sexes have been analyzed, and have proven inconsistent even within an individual strain analyzed multiple times. Strains B6 and 129P3/J have been extensively evaluated at multiple ages between 3 and 24 months of age. Sex differences were always absent in strain 129P3/J and typically absent in strain B6. In strain B6, however, males infrequently had significantly higher IOP than females. For example, in one experiment, B6 males had an average IOP of 14.2 ± 0.3 mmHg (n = 12) whereas the average IOP of females was 13.1 ± 0.3 mmHg (n = 12, P = 0.01). If real, this sporadic sex difference was not dependent on age, sometimes occurring in a group of B6 mice at a particular age and sometimes not occurring in a separate group of the same age. Anesthesia protocol avoids IOP alteration and allows detection of diurnal differences All IOPs were assessed using an anesthetic regime of 99 mg/kg ketamine and 9 mg/kg xylazine (defined as 1X). Initial experiments suggested that an almost identical dose (100 mg/kg ketamine and 9 mg/kg xylazine) of anesthesia had no effect on IOP during the experimental period with IOP being measured as soon as possible after the mouse was unconscious, typically minutes. [13]. To further assess the effects of anesthesia, we measured IOP in groups of genetically identical B6 mice subjected to different doses (1X, 1.5X and 2X) at 5 and 25 minutes after administration (Figure 5). For all doses, IOP decreased by 25 minutes (P = 0.005 for time). The greater the dose the greater the decrease in IOP. At the 5 minute measurement, however, IOP was the same using all doses suggesting that the anesthetic effect on IOP had not yet occurred. To identify any early window when it may be possible to assess IOP without an obvious anesthetic effect, 195 mice of strain B6 were anesthetized with the 1X dose and IOP was measured at 1 minute time points between 4 and 12 minutes after administration (Figure 5). The mean IOP of groups analyzed at each time point did not differ (P = 0.9) indicating that the IOP depressing effect of anesthesia occurs later than 12 minutes after administration. Similar results were obtained using 161 strain 129P3/J and 145 strain DBA/2J mice with the 1X dose (129P3/J, P = 0.1; DBA/2J, P = 0.2). In support of a later effect of anesthesia (since general anesthesia is reported to mask diurnal variation in IOP [21]), we identified increased IOP during the dark compared to the light period of the day in several tested strains (Figure 6). In these experiments, IOP measurements were made between 5 and 12 minutes after administration of anesthesia. Figure 5 No effect of 1X anesthetic dose within 12 minutes of administration. A Mean IOP ± SD is shown for C57BL/6J mice at 5 and 25 minutes after administration of various doses of anesthetic. The 1X dose consisted of 99 mg/kg ketamine and 9 mg/kg xylazine. All doses decreased IOP by 25 minutes. At all doses the IOP at 5 minutes was the same suggesting that the effect of anesthesia had not yet occurred. Approximately thirty 3 to 4 month old mice were analyzed at each dose and time B-D. Scatter-plots demonstrating no change in IOP over the 12 minutes following anesthetic administration in three relatively unrelated mouse strains. All strains consisted of males and females that ranged from 3 to 6 months of age. The sexes and ages were equally represented at each time point. The scatter-plots include 195 C57BL/6J, 161 129P3/J and 145 DBA/2J mice. Figure 6 IOP is increased during the dark compared to light periods in several strains. Mean IOP ± SEM is shown for the indicated strains"
R6744	T8648	T8646	pobj	"strain at different times of measurement. The measurement times within a single year were separated by a few months. The IOPs of strains that were analyzed multiple times in the same year are listed in the chronological order that they were obtained with the earliest measurement on left. The sex [Male (M) or Female (F)], age (months), and number of mice (n) analyzed for the CBA strains are listed starting with the earliest measurement and ending with the latest: CBA/CaJ, F, n = 22, age 6–7; M, n = 11, age 2; CBA/CaHN, F, n = 16, age 3; M, n = 8, age 3. For BALB/cJ and C57BL/6J, all groups were male and primarily 3 to 4 months old. The number of mice analyzed at each time follows: BALB/cJ 8, 10, 11, 15, 18 and 14, C57BL/6J 10, 14, 21,40,40 and 42. Strain name CBA/CaHN-Btkxid/J is abbreviated to CBA/CaHN. Despite the general consistency of IOP, the average IOPs of some strains have changed in a reproducible manner. The IOPs of BALB/cJ mice (low end of spectrum) were very similar for the past several years, around 11 mmHg. Between early 1996 and 1997, however, the IOP of this strain did jump from approximately 7.7 mmHg to approximately 11 mmHg (Figure 3). During this period, the room in which our animals were housed and the manufacturer of the mouse diet were changed. Over the same period, the IOP of A/J also increased dramatically, from 9.4 ± 0.5 mmHg (n = 11) in 1996 to 14.2 ± 0.4 mmHg (n = 19) in 1997. The increased IOP in A/J also was reproducible, with the average IOP of mice assessed in the year 2000 being 14.5 ± 0.4 mmHg (n = 16). Importantly, the IOPs of strains B6 and C3H/HeJ did not change during this time (B6, 12.3. ± 0.5 mmHg in 1996 and 12.4 ± 0.3 mmHg in 1997, n= 10 and 14; C3H/HeJ, 13.7 ± 0.8 mmHg in 1996 and 13.6 ± 0.2 mmHg in 1997, n = 9 and 19). Effect of age on IOP We focused on the commonly used B6, 129P3/J and C3H/HeJ strains to determine the effects of age on IOP (Figure 4). In B6, age had a significant effect on IOP (P < 0.001). IOP was slightly decreased at both 12 months (12.2 ± 0.2 mmHg) and 19 months (12.2 ± 0.3 mmHg) compared to 3 months (13.1 ± 0.3 mmHg) and 7 months (13.3 ± 0.3 mmHg). Although the decrease was of a similar level to the variation observed in 3 month old mice (see Figure 3), the IOPs of control young mice (see Methods) analyzed at the same times as the various B6 age groups did not decrease. For example, control mice analyzed at the same time as the 3 month, 12 month and 18 month B6 age groups had IOPs of 13.0 ± 0.2 mmHg (n = 14), 13.3 ± 0.2 mmHg (n = 14), 13.7 ± 0.4 mmHg (n = 12), respectively. IOP was even lower in the 24 month B6 mice (10.8 ± 0.4 mmHg), and again the average IOP of young controls measured at the same time was not changed (13.5 ± 0.2, n = 12). Figure 4 IOP changes with increasing Age. Mean IOP ± SEM is shown for the indicated strain at different ages. IOP decreased significantly in strains C57BL/6J and 129P3/J but not C3H/HeJ. The C57BL/6J and 129P3/J groups consisted of approximately equal numbers of males and females. The 3 months old C3H/HeJ mice were male while the other ages were composed of males and females. The number of mice analyzed at each age, listed from youngest to oldest, follow: C57BL/6J, 18, 18, 18, 18, 13; 129P3/J, 18, 15, 16, 14, 21; C3H/HeJ, 15, 23 17 and 16. In strain 129P3/J, IOP did not differ significantly with age between 3 and 14 months but was lower in 18 month old mice (P < 0.001 compared to all younger ages, Figure 4). Despite a 1 mmHg dip in IOP at 8 months, there were no significant IOP differences between C3H/HeJ mice at each age tested (P = 0.2 for age). Although the effect of age has not been thoroughly assessed in other strains, no obvious age-related differences have been identified in other strains analyzed at multiple ages except for the glaucomatous DBA/2J and AKXD-28/Ty strains [14,19]. Effect of sex on IOP Although we have not rigorously assessed the effect of sex on IOP in many strains, sex specific differences have not been detected in the majority of strains for which both sexes have been analyzed, and have proven inconsistent even within an individual strain analyzed multiple times. Strains B6 and 129P3/J have been extensively evaluated at multiple ages between 3 and 24 months of age. Sex differences were always absent in strain 129P3/J and typically absent in strain B6. In strain B6, however, males infrequently had significantly higher IOP than females. For example, in one experiment, B6 males had an average IOP of 14.2 ± 0.3 mmHg (n = 12) whereas the average IOP of females was 13.1 ± 0.3 mmHg (n = 12, P = 0.01). If real, this sporadic sex difference was not dependent on age, sometimes occurring in a group of B6 mice at a particular age and sometimes not occurring in a separate group of the same age. Anesthesia protocol avoids IOP alteration and allows detection of diurnal differences All IOPs were assessed using an anesthetic regime of 99 mg/kg ketamine and 9 mg/kg xylazine (defined as 1X). Initial experiments suggested that an almost identical dose (100 mg/kg ketamine and 9 mg/kg xylazine) of anesthesia had no effect on IOP during the experimental period with IOP being measured as soon as possible after the mouse was unconscious, typically minutes. [13]. To further assess the effects of anesthesia, we measured IOP in groups of genetically identical B6 mice subjected to different doses (1X, 1.5X and 2X) at 5 and 25 minutes after administration (Figure 5). For all doses, IOP decreased by 25 minutes (P = 0.005 for time). The greater the dose the greater the decrease in IOP. At the 5 minute measurement, however, IOP was the same using all doses suggesting that the anesthetic effect on IOP had not yet occurred. To identify any early window when it may be possible to assess IOP without an obvious anesthetic effect, 195 mice of strain B6 were anesthetized with the 1X dose and IOP was measured at 1 minute time points between 4 and 12 minutes after administration (Figure 5). The mean IOP of groups analyzed at each time point did not differ (P = 0.9) indicating that the IOP depressing effect of anesthesia occurs later than 12 minutes after administration. Similar results were obtained using 161 strain 129P3/J and 145 strain DBA/2J mice with the 1X dose (129P3/J, P = 0.1; DBA/2J, P = 0.2). In support of a later effect of anesthesia (since general anesthesia is reported to mask diurnal variation in IOP [21]), we identified increased IOP during the dark compared to the light period of the day in several tested strains (Figure 6). In these experiments, IOP measurements were made between 5 and 12 minutes after administration of anesthesia. Figure 5 No effect of 1X anesthetic dose within 12 minutes of administration. A Mean IOP ± SD is shown for C57BL/6J mice at 5 and 25 minutes after administration of various doses of anesthetic. The 1X dose consisted of 99 mg/kg ketamine and 9 mg/kg xylazine. All doses decreased IOP by 25 minutes. At all doses the IOP at 5 minutes was the same suggesting that the effect of anesthesia had not yet occurred. Approximately thirty 3 to 4 month old mice were analyzed at each dose and time B-D. Scatter-plots demonstrating no change in IOP over the 12 minutes following anesthetic administration in three relatively unrelated mouse strains. All strains consisted of males and females that ranged from 3 to 6 months of age. The sexes and ages were equally represented at each time point. The scatter-plots include 195 C57BL/6J, 161 129P3/J and 145 DBA/2J mice. Figure 6 IOP is increased during the dark compared to light periods in several strains. Mean IOP ± SEM is shown for the indicated strains",for
R6745	T8649	T8648	amod	indicated,"strain at different times of measurement. The measurement times within a single year were separated by a few months. The IOPs of strains that were analyzed multiple times in the same year are listed in the chronological order that they were obtained with the earliest measurement on left. The sex [Male (M) or Female (F)], age (months), and number of mice (n) analyzed for the CBA strains are listed starting with the earliest measurement and ending with the latest: CBA/CaJ, F, n = 22, age 6–7; M, n = 11, age 2; CBA/CaHN, F, n = 16, age 3; M, n = 8, age 3. For BALB/cJ and C57BL/6J, all groups were male and primarily 3 to 4 months old. The number of mice analyzed at each time follows: BALB/cJ 8, 10, 11, 15, 18 and 14, C57BL/6J 10, 14, 21,40,40 and 42. Strain name CBA/CaHN-Btkxid/J is abbreviated to CBA/CaHN. Despite the general consistency of IOP, the average IOPs of some strains have changed in a reproducible manner. The IOPs of BALB/cJ mice (low end of spectrum) were very similar for the past several years, around 11 mmHg. Between early 1996 and 1997, however, the IOP of this strain did jump from approximately 7.7 mmHg to approximately 11 mmHg (Figure 3). During this period, the room in which our animals were housed and the manufacturer of the mouse diet were changed. Over the same period, the IOP of A/J also increased dramatically, from 9.4 ± 0.5 mmHg (n = 11) in 1996 to 14.2 ± 0.4 mmHg (n = 19) in 1997. The increased IOP in A/J also was reproducible, with the average IOP of mice assessed in the year 2000 being 14.5 ± 0.4 mmHg (n = 16). Importantly, the IOPs of strains B6 and C3H/HeJ did not change during this time (B6, 12.3. ± 0.5 mmHg in 1996 and 12.4 ± 0.3 mmHg in 1997, n= 10 and 14; C3H/HeJ, 13.7 ± 0.8 mmHg in 1996 and 13.6 ± 0.2 mmHg in 1997, n = 9 and 19). Effect of age on IOP We focused on the commonly used B6, 129P3/J and C3H/HeJ strains to determine the effects of age on IOP (Figure 4). In B6, age had a significant effect on IOP (P < 0.001). IOP was slightly decreased at both 12 months (12.2 ± 0.2 mmHg) and 19 months (12.2 ± 0.3 mmHg) compared to 3 months (13.1 ± 0.3 mmHg) and 7 months (13.3 ± 0.3 mmHg). Although the decrease was of a similar level to the variation observed in 3 month old mice (see Figure 3), the IOPs of control young mice (see Methods) analyzed at the same times as the various B6 age groups did not decrease. For example, control mice analyzed at the same time as the 3 month, 12 month and 18 month B6 age groups had IOPs of 13.0 ± 0.2 mmHg (n = 14), 13.3 ± 0.2 mmHg (n = 14), 13.7 ± 0.4 mmHg (n = 12), respectively. IOP was even lower in the 24 month B6 mice (10.8 ± 0.4 mmHg), and again the average IOP of young controls measured at the same time was not changed (13.5 ± 0.2, n = 12). Figure 4 IOP changes with increasing Age. Mean IOP ± SEM is shown for the indicated strain at different ages. IOP decreased significantly in strains C57BL/6J and 129P3/J but not C3H/HeJ. The C57BL/6J and 129P3/J groups consisted of approximately equal numbers of males and females. The 3 months old C3H/HeJ mice were male while the other ages were composed of males and females. The number of mice analyzed at each age, listed from youngest to oldest, follow: C57BL/6J, 18, 18, 18, 18, 13; 129P3/J, 18, 15, 16, 14, 21; C3H/HeJ, 15, 23 17 and 16. In strain 129P3/J, IOP did not differ significantly with age between 3 and 14 months but was lower in 18 month old mice (P < 0.001 compared to all younger ages, Figure 4). Despite a 1 mmHg dip in IOP at 8 months, there were no significant IOP differences between C3H/HeJ mice at each age tested (P = 0.2 for age). Although the effect of age has not been thoroughly assessed in other strains, no obvious age-related differences have been identified in other strains analyzed at multiple ages except for the glaucomatous DBA/2J and AKXD-28/Ty strains [14,19]. Effect of sex on IOP Although we have not rigorously assessed the effect of sex on IOP in many strains, sex specific differences have not been detected in the majority of strains for which both sexes have been analyzed, and have proven inconsistent even within an individual strain analyzed multiple times. Strains B6 and 129P3/J have been extensively evaluated at multiple ages between 3 and 24 months of age. Sex differences were always absent in strain 129P3/J and typically absent in strain B6. In strain B6, however, males infrequently had significantly higher IOP than females. For example, in one experiment, B6 males had an average IOP of 14.2 ± 0.3 mmHg (n = 12) whereas the average IOP of females was 13.1 ± 0.3 mmHg (n = 12, P = 0.01). If real, this sporadic sex difference was not dependent on age, sometimes occurring in a group of B6 mice at a particular age and sometimes not occurring in a separate group of the same age. Anesthesia protocol avoids IOP alteration and allows detection of diurnal differences All IOPs were assessed using an anesthetic regime of 99 mg/kg ketamine and 9 mg/kg xylazine (defined as 1X). Initial experiments suggested that an almost identical dose (100 mg/kg ketamine and 9 mg/kg xylazine) of anesthesia had no effect on IOP during the experimental period with IOP being measured as soon as possible after the mouse was unconscious, typically minutes. [13]. To further assess the effects of anesthesia, we measured IOP in groups of genetically identical B6 mice subjected to different doses (1X, 1.5X and 2X) at 5 and 25 minutes after administration (Figure 5). For all doses, IOP decreased by 25 minutes (P = 0.005 for time). The greater the dose the greater the decrease in IOP. At the 5 minute measurement, however, IOP was the same using all doses suggesting that the anesthetic effect on IOP had not yet occurred. To identify any early window when it may be possible to assess IOP without an obvious anesthetic effect, 195 mice of strain B6 were anesthetized with the 1X dose and IOP was measured at 1 minute time points between 4 and 12 minutes after administration (Figure 5). The mean IOP of groups analyzed at each time point did not differ (P = 0.9) indicating that the IOP depressing effect of anesthesia occurs later than 12 minutes after administration. Similar results were obtained using 161 strain 129P3/J and 145 strain DBA/2J mice with the 1X dose (129P3/J, P = 0.1; DBA/2J, P = 0.2). In support of a later effect of anesthesia (since general anesthesia is reported to mask diurnal variation in IOP [21]), we identified increased IOP during the dark compared to the light period of the day in several tested strains (Figure 6). In these experiments, IOP measurements were made between 5 and 12 minutes after administration of anesthesia. Figure 5 No effect of 1X anesthetic dose within 12 minutes of administration. A Mean IOP ± SD is shown for C57BL/6J mice at 5 and 25 minutes after administration of various doses of anesthetic. The 1X dose consisted of 99 mg/kg ketamine and 9 mg/kg xylazine. All doses decreased IOP by 25 minutes. At all doses the IOP at 5 minutes was the same suggesting that the effect of anesthesia had not yet occurred. Approximately thirty 3 to 4 month old mice were analyzed at each dose and time B-D. Scatter-plots demonstrating no change in IOP over the 12 minutes following anesthetic administration in three relatively unrelated mouse strains. All strains consisted of males and females that ranged from 3 to 6 months of age. The sexes and ages were equally represented at each time point. The scatter-plots include 195 C57BL/6J, 161 129P3/J and 145 DBA/2J mice. Figure 6 IOP is increased during the dark compared to light periods in several strains. Mean IOP ± SEM is shown for the indicated strains"
R6746	T8650	T8642	prep	at,shown
R6747	T8651	T8650	pobj	measurement,at
R6748	T8652	T8651	prep	during,measurement
R6749	T8653	T8654	det	the,periods
R675	T925	T926	expl	There,is
R6750	T8654	T8652	pobj	periods,during
R6751	T8655	T8654	amod	light,periods
R6752	T8656	T8657	punct	(,bars
R6753	T8657	T8655	parataxis	bars,light
R6754	T8658	T8657	amod	open,bars
R6755	T8659	T8657	punct	),bars
R6756	T8660	T8655	cc	or,light
R6757	T8661	T8655	conj	dark,light
R6758	T8662	T8663	punct	(,bars
R6759	T8663	T8661	parataxis	bars,dark
R676	T927	T928	det	a,range
R6760	T8664	T8663	amod	filled,bars
R6761	T8665	T8663	punct	),bars
R6762	T8666	T8654	prep	of,periods
R6763	T8667	T8668	det	the,day
R6764	T8668	T8666	pobj	day,of
R6765	T8669	T8642	punct	.,shown
R6766	T8671	T8672	det	All,mice
R6767	T8672	T8673	nsubj	mice,were
R6768	T8674	T8675	quantmod	2,4
R6769	T8675	T8677	nummod	4,months
R677	T928	T926	attr	range,is
R6770	T8676	T8675	quantmod	to,4
R6771	T8677	T8678	npadvmod	months,old
R6772	T8678	T8673	acomp	old,were
R6773	T8679	T8673	prep	except,were
R6774	T8680	T8679	prep	for,except
R6775	T8681	T8682	compound	CBA,CaJ
R6776	T8682	T8680	pobj	CaJ,for
R6777	T8683	T8682	punct	/,CaJ
R6778	T8684	T8685	dep	that,were
R6779	T8685	T8682	relcl	were,CaJ
R678	T929	T928	amod	wide,range
R6780	T8686	T8687	quantmod	5,6
R6781	T8687	T8689	nummod	6,months
R6782	T8688	T8687	quantmod	to,6
R6783	T8689	T8690	npadvmod	months,old
R6784	T8690	T8685	acomp	old,were
R6785	T8691	T8673	punct	.,were
R6786	T8693	T8694	nsubj	129B6,refers
R6787	T8695	T8694	prep	to,refers
R6788	T8696	T8695	pobj	mice,to
R6789	T8697	T8696	prep	of,mice
R679	T930	T928	prep	of,range
R6790	T8698	T8699	det	a,background
R6791	T8699	T8697	pobj	background,of
R6792	T8700	T8699	amod	mixed,background
R6793	T8701	T8702	nmod	129X1,SvJ
R6794	T8702	T8699	nmod	SvJ,background
R6795	T8703	T8702	punct	/,SvJ
R6796	T8704	T8702	cc	and,SvJ
R6797	T8705	T8706	compound	C57BL,6J
R6798	T8706	T8702	conj	6J,SvJ
R6799	T8707	T8706	punct	/,6J
R68	T104	T105	det	the,effects
R680	T931	T930	pobj	IOP,of
R6800	T8708	T8694	punct	.,refers
R6801	T8710	T8711	nsubjpass	IOP,increased
R6802	T8712	T8711	auxpass	was,increased
R6803	T8713	T8711	prep	during,increased
R6804	T8714	T8715	det	the,dark
R6805	T8715	T8713	pobj	dark,during
R6806	T8716	T8711	prep	in,increased
R6807	T8717	T8718	det	all,strains
R6808	T8718	T8716	pobj	strains,in
R6809	T8719	T8718	prep	except,strains
R681	T932	T926	prep	with,is
R6810	T8720	T8721	compound	CBA,CaJ
R6811	T8721	T8719	pobj	CaJ,except
R6812	T8722	T8721	punct	/,CaJ
R6813	T8723	T8711	punct	.,increased
R6814	T8725	T8726	det	The,number
R6815	T8726	T8727	nsubj	number,follows
R6816	T8728	T8726	prep	of,number
R6817	T8729	T8728	pobj	mice,of
R6818	T8730	T8731	advmod	successfully,analyzed
R6819	T8731	T8726	acl	analyzed,number
R682	T933	T934	compound	strain,cJ
R6820	T8732	T8731	prep	during,analyzed
R6821	T8733	T8734	det	the,periods
R6822	T8734	T8732	pobj	periods,during
R6823	T8735	T8736	amod	light,L
R6824	T8736	T8734	amod	L,periods
R6825	T8737	T8736	punct	(,L
R6826	T8738	T8736	punct	),L
R6827	T8739	T8736	cc	or,L
R6828	T8740	T8741	amod	dark,D
R6829	T8741	T8736	conj	D,L
R683	T934	T937	nsubj	cJ,having
R6830	T8742	T8741	punct	(,D
R6831	T8743	T8734	punct	),periods
R6832	T8744	T8727	punct	", ",follows
R6833	T8745	T8746	compound	DBA,2J
R6834	T8746	T8748	dep	2J,10D
R6835	T8747	T8746	punct	/,2J
R6836	T8748	T8751	dep	10D,16D
R6837	T8749	T8748	nmod	10L,10D
R6838	T8750	T8748	punct	",",10D
R6839	T8751	T8727	dep	16D,follows
R684	T935	T934	compound	BALB,cJ
R6840	T8752	T8751	punct	;,16D
R6841	T8753	T8754	compound	C57BL,6J
R6842	T8754	T8756	dep	6J,22D
R6843	T8755	T8754	punct	/,6J
R6844	T8756	T8751	dep	22D,16D
R6845	T8757	T8756	nmod	32L,22D
R6846	T8758	T8756	punct	", ",22D
R6847	T8759	T8751	punct	;,16D
R6848	T8760	T8761	compound	C57BR,cdJ
R6849	T8761	T8763	dep	cdJ,10D
R685	T936	T934	punct	/,cJ
R6850	T8762	T8761	punct	/,cdJ
R6851	T8763	T8751	dep	10D,16D
R6852	T8764	T8763	nmod	12L,10D
R6853	T8765	T8763	punct	",",10D
R6854	T8766	T8751	punct	;,16D
R6855	T8767	T8768	compound	SWR,J
R6856	T8768	T8770	dep	J,16D
R6857	T8769	T8768	punct	/,J
R6858	T8770	T8751	dep	16D,16D
R6859	T8771	T8770	nmod	16L,16D
R686	T937	T932	pobj	having,with
R6860	T8772	T8770	punct	", ",16D
R6861	T8773	T8751	punct	;,16D
R6862	T8774	T8775	compound	BALB,cByJ
R6863	T8775	T8777	dep	cByJ,16D
R6864	T8776	T8775	punct	/,cByJ
R6865	T8777	T8751	dep	16D,16D
R6866	T8778	T8777	nmod	15L,16D
R6867	T8779	T8777	punct	", ",16D
R6868	T8780	T8751	punct	;,16D
R6869	T8781	T8782	dep	129B6,12D
R687	T938	T937	dobj	one,having
R6870	T8782	T8751	dep	12D,16D
R6871	T8783	T8782	nmod	10L,12D
R6872	T8784	T8782	punct	", ",12D
R6873	T8785	T8751	punct	;,16D
R6874	T8786	T8787	compound	CBA,CaJ
R6875	T8787	T8751	dep	CaJ,16D
R6876	T8788	T8787	punct	/,CaJ
R6877	T8789	T8751	nmod	22L,16D
R6878	T8790	T8751	punct	", ",16D
R6879	T8791	T8751	punct	.,16D
R688	T939	T938	prep	of,one
R6880	T8800	T8801	det	No,correlation
R6881	T8802	T8801	prep	between,correlation
R6882	T8803	T8804	compound	blood,pressure
R6883	T8804	T8802	pobj	pressure,between
R6884	T8805	T8804	cc	and,pressure
R6885	T8806	T8804	conj	IOP,pressure
R6886	T8807	T8801	punct	.,correlation
R6887	T8809	T8810	expl	There,is
R6888	T8811	T8812	det	no,correlation
R6889	T8812	T8810	attr	correlation,is
R689	T940	T941	det	the,IOPs
R6890	T8813	T8812	amod	strong,correlation
R6891	T8814	T8812	prep	between,correlation
R6892	T8815	T8816	det	the,pressure
R6893	T8816	T8814	pobj	pressure,between
R6894	T8817	T8816	amod	average,pressure
R6895	T8818	T8816	amod	systolic,pressure
R6896	T8819	T8816	compound	blood,pressure
R6897	T8820	T8816	prep	of,pressure
R6898	T8821	T8822	det	each,strain
R6899	T8822	T8820	pobj	strain,of
R69	T105	T103	dobj	effects,assess
R690	T941	T939	pobj	IOPs,of
R6900	T8823	T8816	cc	and,pressure
R6901	T8824	T8825	det	the,IOP
R6902	T8825	T8816	conj	IOP,pressure
R6903	T8826	T8825	amod	average,IOP
R6904	T8827	T8825	prep	of,IOP
R6905	T8828	T8829	det	that,strain
R6906	T8829	T8827	pobj	strain,of
R6907	T8830	T8831	punct	(,0.1
R6908	T8831	T8812	parataxis	0.1,correlation
R6909	T8832	T8831	nsubj	R2,0.1
R691	T942	T941	amod	lowest,IOPs
R6910	T8833	T8831	punct	=,0.1
R6911	T8834	T8831	punct	),0.1
R6912	T8835	T8810	punct	.,is
R6913	T8837	T8838	det	All,mice
R6914	T8838	T8839	nsubj	mice,were
R6915	T8840	T8839	acomp	female,were
R6916	T8841	T8840	cc	and,female
R6917	T8842	T8843	quantmod	2,4
R6918	T8843	T8845	nummod	4,months
R6919	T8844	T8843	quantmod	to,4
R692	T943	T941	amod	average,IOPs
R6920	T8845	T8846	npadvmod	months,old
R6921	T8846	T8840	conj	old,female
R6922	T8847	T8839	punct	", ",were
R6923	T8848	T8839	prep	with,were
R6924	T8849	T8850	det	the,exception
R6925	T8850	T8848	pobj	exception,with
R6926	T8851	T8852	mark	that,were
R6927	T8852	T8850	acl	were,exception
R6928	T8853	T8854	det	the,CaJ
R6929	T8854	T8852	nsubj	CaJ,were
R693	T944	T941	punct	(,IOPs
R6930	T8855	T8854	amod	female,CaJ
R6931	T8856	T8854	compound	CBA,CaJ
R6932	T8857	T8854	punct	/,CaJ
R6933	T8858	T8854	acl	used,CaJ
R6934	T8859	T8858	prep	for,used
R6935	T8860	T8861	compound	IOP,assessment
R6936	T8861	T8859	pobj	assessment,for
R6937	T8862	T8863	quantmod	6,7
R6938	T8863	T8865	nummod	7,months
R6939	T8864	T8863	quantmod	to,7
R694	T945	T946	quantmod	11.1,0.5
R6940	T8865	T8866	npadvmod	months,old
R6941	T8866	T8852	acomp	old,were
R6942	T8867	T8839	punct	.,were
R6943	T8869	T8870	mark	If,excluded
R6944	T8870	T8877	advcl	excluded,drops
R6945	T8871	T8872	det	the,mice
R6946	T8872	T8870	nsubjpass	mice,excluded
R6947	T8873	T8874	compound	CBA,CaJ
R6948	T8874	T8872	compound	CaJ,mice
R6949	T8875	T8874	punct	/,CaJ
R695	T946	T948	nummod	0.5,mmHg
R6950	T8876	T8870	auxpass	are,excluded
R6951	T8877	T8880	ccomp	drops,had
R6952	T8878	T8877	punct	", ",drops
R6953	T8879	T8877	nsubj	R2,drops
R6954	T8881	T8877	prep	to,drops
R6955	T8882	T8881	pobj	0.01,to
R6956	T8883	T8882	prep	of,0.01
R6957	T8884	T8885	compound	ARK,J
R6958	T8885	T8883	pobj	J,of
R6959	T8886	T8885	punct	/,J
R696	T947	T946	punct	±,0.5
R6960	T8887	T8885	punct	", ",J
R6961	T8888	T8889	compound	C57BL,6J
R6962	T8889	T8885	conj	6J,J
R6963	T8890	T8889	punct	/,6J
R6964	T8891	T8889	cc	and,6J
R6965	T8892	T8893	compound	SJL,J
R6966	T8893	T8889	conj	J,6J
R6967	T8894	T8893	punct	/,J
R6968	T8895	T8880	punct	", ",had
R6969	T8896	T8897	compound	strain,J
R697	T948	T941	appos	mmHg,IOPs
R6970	T8897	T8880	nsubj	J,had
R6971	T8898	T8897	compound	ARK,J
R6972	T8899	T8897	punct	/,J
R6973	T8900	T8901	det	the,IOP
R6974	T8901	T8880	dobj	IOP,had
R6975	T8902	T8901	amod	lowest,IOP
R6976	T8903	T8880	punct	.,had
R6977	T8918	T8919	compound	Myoc,alleles
R6978	T8919	T8920	nsubj	alleles,associate
R6979	T8921	T8920	aux	do,associate
R698	T949	T937	punct	),having
R6980	T8922	T8920	neg	not,associate
R6981	T8923	T8920	prep	with,associate
R6982	T8924	T8923	pobj	IOP,with
R6983	T8925	T8920	punct	.,associate
R6984	T8927	T8928	nsubj	Sequencing,identified
R6985	T8929	T8930	nummod	two,alleles
R6986	T8930	T8928	dobj	alleles,identified
R6987	T8931	T8930	prep	of,alleles
R6988	T8932	T8931	pobj	Myoc,of
R6989	T8933	T8928	prep	in,identified
R699	T950	T937	cc	and,having
R6990	T8934	T8935	det	these,strains
R6991	T8935	T8933	pobj	strains,in
R6992	T8936	T8935	compound	mouse,strains
R6993	T8937	T8938	punct	(,see
R6994	T8938	T8928	parataxis	see,identified
R6995	T8939	T8938	dobj	text,see
R6996	T8940	T8938	punct	),see
R6997	T8941	T8928	punct	.,identified
R6998	T8943	T8944	compound	Mouse,strains
R6999	T8944	T8945	nsubjpass	strains,shown
R7	T36	T31	punct	: ,update
R70	T106	T105	prep	of,effects
R700	T951	T952	compound	strain,CaJ
R7000	T8946	T8944	amod	homozygous,strains
R7001	T8947	T8946	prep	for,homozygous
R7002	T8948	T8949	det	an,allele
R7003	T8949	T8947	pobj	allele,for
R7004	T8950	T8949	acl	having,allele
R7005	T8951	T8952	det	a,insertion
R7006	T8952	T8950	dobj	insertion,having
R7007	T8953	T8954	nummod	12,bp
R7008	T8954	T8952	compound	bp,insertion
R7009	T8955	T8950	prep	in,having
R701	T952	T955	nsubj	CaJ,one
R7010	T8956	T8957	det	the,region
R7011	T8957	T8955	pobj	region,in
R7012	T8958	T8957	compound	promoter,region
R7013	T8959	T8945	auxpass	are,shown
R7014	T8960	T8945	prep	as,shown
R7015	T8961	T8962	amod	open,bars
R7016	T8962	T8960	pobj	bars,as
R7017	T8963	T8945	cc	and,shown
R7018	T8964	T8965	nsubj	strains,have
R7019	T8965	T8945	conj	have,shown
R702	T953	T952	compound	CBA,CaJ
R7020	T8966	T8964	amod	homozygous,strains
R7021	T8967	T8966	prep	for,homozygous
R7022	T8968	T8969	det	the,allele
R7023	T8969	T8967	pobj	allele,for
R7024	T8970	T8969	prep	without,allele
R7025	T8971	T8972	det	this,insertion
R7026	T8972	T8970	pobj	insertion,without
R7027	T8973	T8974	amod	filled,bars
R7028	T8974	T8965	dobj	bars,have
R7029	T8975	T8965	punct	.,have
R703	T954	T952	punct	/,CaJ
R7030	T8977	T8978	det	The,data
R7031	T8978	T8980	nsubj	data,is
R7032	T8979	T8978	compound	IOP,data
R7033	T8981	T8982	det	the,same
R7034	T8982	T8980	attr	same,is
R7035	T8983	T8982	prep	as,same
R7036	T8984	T8983	pobj	that,as
R7037	T8985	T8984	prep	in,that
R7038	T8986	T8985	pobj	Figure,in
R7039	T8987	T8986	nummod	1,Figure
R704	T955	T937	conj	one,having
R7040	T8988	T8980	punct	.,is
R7041	T9017	T9016	prep	of,Effects
R7042	T9018	T9019	amod	genetic,alterations
R7043	T9019	T9017	pobj	alterations,of
R7044	T9020	T9016	punct	.,Effects
R7045	T9022	T9023	compound	Mean,IOP
R7046	T9023	T9024	nsubjpass	IOP,shown
R7047	T9025	T9023	punct	±,IOP
R7048	T9026	T9023	appos	SEM,IOP
R7049	T9027	T9024	auxpass	is,shown
R705	T956	T955	prep	of,one
R7050	T9028	T9024	punct	.,shown
R7051	T9030	T9031	expl	There,is
R7052	T9032	T9033	det	no,difference
R7053	T9033	T9031	attr	difference,is
R7054	T9034	T9033	prep	in,difference
R7055	T9035	T9034	pobj	IOP,in
R7056	T9036	T9033	prep	between,difference
R7057	T9037	T9038	quantmod	3,4
R7058	T9038	T9040	nummod	4,month
R7059	T9039	T9038	quantmod	to,4
R706	T957	T958	det	the,IOPs
R7060	T9040	T9041	npadvmod	month,old
R7061	T9041	T9042	amod	old,males
R7062	T9042	T9036	pobj	males,between
R7063	T9043	T9042	prep	with,males
R7064	T9044	T9045	preconj	either,Ola
R7065	T9045	T9043	pobj	Ola,with
R7066	T9046	T9045	det	the,Ola
R7067	T9047	T9045	compound	129P2,Ola
R7068	T9048	T9045	punct	/,Ola
R7069	T9049	T9050	punct	(,18
R707	T958	T956	pobj	IOPs,of
R7070	T9050	T9045	parataxis	18,Ola
R7071	T9051	T9050	nsubj	n,18
R7072	T9052	T9050	punct	=,18
R7073	T9053	T9050	punct	),18
R7074	T9054	T9045	cc	or,Ola
R7075	T9055	T9056	compound	C57BL,6J
R7076	T9056	T9045	conj	6J,Ola
R7077	T9057	T9056	punct	/,6J
R7078	T9058	T9059	punct	(,20
R7079	T9059	T9056	parataxis	20,6J
R708	T959	T958	amod	highest,IOPs
R7080	T9060	T9059	nsubj	n,20
R7081	T9061	T9059	punct	=,20
R7082	T9062	T9059	punct	),20
R7083	T9063	T9064	compound	Y,chromosome
R7084	T9064	T9056	appos	chromosome,6J
R7085	T9065	T9064	punct	(,chromosome
R7086	T9066	T9067	compound	Y,Chr
R7087	T9067	T9064	appos	Chr,chromosome
R7088	T9068	T9031	punct	),is
R7089	T9069	T9031	punct	.,is
R709	T960	T958	punct	(,IOPs
R7090	T9071	T9072	det	The,Chr
R7091	T9072	T9075	nsubjpass	Chr,backcrossed
R7092	T9073	T9074	nummod	129,Y
R7093	T9074	T9072	compound	Y,Chr
R7094	T9076	T9075	aux	had,backcrossed
R7095	T9077	T9075	auxpass	been,backcrossed
R7096	T9078	T9075	prep	to,backcrossed
R7097	T9079	T9080	compound	strain,6J
R7098	T9080	T9078	pobj	6J,to
R7099	T9081	T9080	compound	C57BL,6J
R71	T107	T108	amod	specific,mutations
R710	T961	T962	quantmod	19.3,0.3
R7100	T9082	T9080	punct	/,6J
R7101	T9083	T9075	prep	for,backcrossed
R7102	T9084	T9085	nummod	11,generations
R7103	T9085	T9083	pobj	generations,for
R7104	T9086	T9075	punct	.,backcrossed
R7105	T9088	T9089	advmod	Similarly,have
R7106	T9090	T9089	punct	", ",have
R7107	T9091	T9092	quantmod	6,9
R7108	T9092	T9094	nummod	9,month
R7109	T9093	T9092	quantmod	to,9
R711	T962	T964	nummod	0.3,mmHg
R7110	T9094	T9095	npadvmod	month,old
R7111	T9095	T9096	amod	old,males
R7112	T9096	T9089	nsubj	males,have
R7113	T9097	T9096	cc	and,males
R7114	T9098	T9096	conj	females,males
R7115	T9099	T9100	dep	that,are
R7116	T9100	T9096	relcl	are,males
R7117	T9101	T9100	acomp	homozygous,are
R7118	T9102	T9101	prep	for,homozygous
R7119	T9103	T9104	amod	normal,alleles
R712	T963	T962	punct	±,0.3
R7120	T9104	T9102	pobj	alleles,for
R7121	T9105	T9106	punct	(,+
R7122	T9106	T9103	punct	+,normal
R7123	T9107	T9106	punct	),+
R7124	T9108	T9103	cc	or,normal
R7125	T9109	T9103	conj	mutant,normal
R7126	T9110	T9111	punct	(,n
R7127	T9111	T9109	parataxis	n,mutant
R7128	T9112	T9111	punct	),n
R7129	T9113	T9104	prep	of,alleles
R713	T964	T958	appos	mmHg,IOPs
R7130	T9114	T9113	pobj	Car2,of
R7131	T9115	T9116	amod	similar,IOPs
R7132	T9116	T9089	dobj	IOPs,have
R7133	T9117	T9118	punct	(,18
R7134	T9118	T9089	parataxis	18,have
R7135	T9119	T9118	nsubj	n,18
R7136	T9120	T9118	punct	=,18
R7137	T9121	T9118	cc	and,18
R7138	T9122	T9118	conj	14,18
R7139	T9123	T9118	punct	", ",18
R714	T965	T926	punct	),is
R7140	T9124	T9118	advmod	respectively,18
R7141	T9125	T9118	punct	),18
R7142	T9126	T9089	punct	.,have
R7143	T9128	T9129	advmod	However,had
R7144	T9130	T9129	punct	", ",had
R7145	T9131	T9132	nummod	4,months
R7146	T9132	T9133	npadvmod	months,old
R7147	T9133	T9134	amod	old,males
R7148	T9134	T9129	nsubj	males,had
R7149	T9135	T9134	amod	homozygous,males
R715	T966	T926	punct	.,is
R7150	T9136	T9135	prep	for,homozygous
R7151	T9137	T9138	det	the,mutation
R7152	T9138	T9136	pobj	mutation,for
R7153	T9139	T9140	nmod	Lepr,diabetes
R7154	T9140	T9138	nmod	diabetes,mutation
R7155	T9141	T9140	cc	and,diabetes
R7156	T9142	T9143	npadvmod	obesity,causing
R7157	T9143	T9140	conj	causing,diabetes
R7158	T9144	T9138	punct	(,mutation
R7159	T9145	T9138	appos	db,mutation
R716	T968	T969	amod	Significant,differences
R7160	T9146	T9129	punct	),had
R7161	T9147	T9148	advmod	significantly,higher
R7162	T9148	T9149	amod	higher,IOPs
R7163	T9149	T9129	dobj	IOPs,had
R7164	T9150	T9149	prep	than,IOPs
R7165	T9151	T9152	poss	their,littermates
R7166	T9152	T9150	pobj	littermates,than
R7167	T9153	T9152	amod	heterozygous,littermates
R7168	T9154	T9155	npadvmod	age,matched
R7169	T9155	T9152	amod	matched,littermates
R717	T969	T970	nsubj	differences,exist
R7170	T9156	T9154	cc	and,age
R7171	T9157	T9154	conj	sex,age
R7172	T9158	T9129	punct	.,had
R7173	T9160	T9161	det	The,weight
R7174	T9161	T9164	nsubj	weight,was
R7175	T9162	T9161	amod	average,weight
R7176	T9163	T9161	compound	body,weight
R7177	T9165	T9161	prep	of,weight
R7178	T9166	T9167	det	the,homozygotes
R7179	T9167	T9165	pobj	homozygotes,of
R718	T971	T970	prep	among,exist
R7180	T9168	T9167	cc	and,homozygotes
R7181	T9169	T9167	conj	heterozygotes,homozygotes
R7182	T9170	T9171	nummod	59,g
R7183	T9171	T9164	attr	g,was
R7184	T9172	T9171	punct	(,g
R7185	T9173	T9171	appos	range,g
R7186	T9174	T9175	quantmod	50,64
R7187	T9175	T9177	nummod	64,g
R7188	T9176	T9175	quantmod	to,64
R7189	T9177	T9173	appos	g,range
R719	T972	T973	amod	various,strains
R7190	T9178	T9171	punct	),g
R7191	T9179	T9171	cc	and,g
R7192	T9180	T9181	nummod	35,g
R7193	T9181	T9171	conj	g,g
R7194	T9182	T9181	punct	(,g
R7195	T9183	T9181	appos	range,g
R7196	T9184	T9185	quantmod	28,41
R7197	T9185	T9187	nummod	41,g
R7198	T9186	T9185	quantmod	to,41
R7199	T9187	T9183	appos	g,range
R72	T108	T106	pobj	mutations,of
R720	T973	T971	pobj	strains,among
R7200	T9188	T9164	punct	),was
R7201	T9189	T9164	advmod	respectively,was
R7202	T9190	T9164	punct	.,was
R7203	T9192	T9193	compound	Blood,sugar
R7204	T9193	T9194	compound	sugar,levels
R7205	T9194	T9195	nsubj	levels,are
R7206	T9196	T9194	prep	in,levels
R7207	T9197	T9198	compound	db,db
R7208	T9198	T9200	compound	db,males
R7209	T9199	T9198	punct	/,db
R721	T974	T975	punct	(,ANOVA
R7210	T9200	T9196	pobj	males,in
R7211	T9201	T9200	prep	of,males
R7212	T9202	T9203	det	this,age
R7213	T9203	T9201	pobj	age,of
R7214	T9204	T9205	advmod	almost,always
R7215	T9205	T9195	advmod	always,are
R7216	T9206	T9195	prep	in,are
R7217	T9207	T9208	det	the,range
R7218	T9208	T9206	pobj	range,in
R7219	T9209	T9208	amod	diabetic,range
R722	T975	T970	parataxis	ANOVA,exist
R7220	T9210	T9211	mark	whereas,are
R7221	T9211	T9195	advcl	are,are
R7222	T9212	T9211	nsubj	those,are
R7223	T9213	T9212	prep	of,those
R7224	T9214	T9213	pobj	heterozygotes,of
R7225	T9215	T9211	neg	not,are
R7226	T9216	T9217	punct	[,27
R7227	T9217	T9195	parataxis	27,are
R7228	T9218	T9217	punct	[,27
R7229	T9219	T9217	punct	],27
R723	T976	T977	nsubj	P,0.0001
R7230	T9220	T9217	punct	],27
R7231	T9221	T9195	punct	.,are
R7232	T9223	T9224	nsubjpass	This,confirmed
R7233	T9225	T9224	auxpass	was,confirmed
R7234	T9226	T9224	advmod	recently,confirmed
R7235	T9227	T9224	prep	in,confirmed
R7236	T9228	T9227	pobj	cohorts,in
R7237	T9229	T9228	prep	of,cohorts
R7238	T9230	T9231	advmod	approximately,25
R7239	T9231	T9232	nummod	25,males
R724	T977	T975	ccomp	0.0001,ANOVA
R7240	T9232	T9229	pobj	males,of
R7241	T9233	T9232	prep	of,males
R7242	T9234	T9235	det	each,genotype
R7243	T9235	T9233	pobj	genotype,of
R7244	T9236	T9237	punct	(,SD
R7245	T9237	T9224	parataxis	SD,confirmed
R7246	T9238	T9237	nmod	mean,SD
R7247	T9239	T9237	punct	±,SD
R7248	T9240	T9237	punct	;,SD
R7249	T9241	T9242	compound	db,db
R725	T978	T977	punct	<,0.0001
R7250	T9242	T9244	dep	db,db
R7251	T9243	T9242	punct	/,db
R7252	T9244	T9237	dep	db,SD
R7253	T9245	T9242	nummod	422,db
R7254	T9246	T9242	punct	±,db
R7255	T9247	T9248	nummod	110,mg
R7256	T9248	T9242	appos	mg,db
R7257	T9249	T9250	punct	/,dl
R7258	T9250	T9248	prep	dl,mg
R7259	T9251	T9244	punct	;,db
R726	T979	T977	prep	for,0.0001
R7260	T9252	T9244	punct	/,db
R7261	T9253	T9244	punct	+,db
R7262	T9254	T9244	nummod	147,db
R7263	T9255	T9244	punct	±,db
R7264	T9256	T9257	nummod	19,mg
R7265	T9257	T9244	appos	mg,db
R7266	T9258	T9259	punct	/,dl
R7267	T9259	T9257	prep	dl,mg
R7268	T9260	T9237	punct	;,SD
R7269	T9261	T9237	meta	Anthony,SD
R727	T980	T981	det	all,groups
R7270	T9262	T9261	nmod	Nicholson,Anthony
R7271	T9263	T9261	punct	", ",Anthony
R7272	T9264	T9261	det	The,Anthony
R7273	T9265	T9261	nmod	Jackson,Anthony
R7274	T9266	T9261	nmod	Laboratory,Anthony
R7275	T9267	T9261	punct	", ",Anthony
R7276	T9268	T9261	amod	personal,Anthony
R7277	T9269	T9261	nmod	communication,Anthony
R7278	T9270	T9237	punct	),SD
R7279	T9308	T9309	compound	Tyr,mutation
R728	T981	T979	pobj	groups,for
R7280	T9309	T9310	nsubj	mutation,results
R7281	T9311	T9310	prep	in,results
R7282	T9312	T9313	amod	increased,IOP
R7283	T9313	T9311	pobj	IOP,in
R7284	T9314	T9313	cc	and,IOP
R7285	T9315	T9316	amod	altered,changes
R7286	T9316	T9313	conj	changes,IOP
R7287	T9317	T9316	amod	diurnal,changes
R7288	T9320	T9319	punct	.,A
R7289	T9322	T9323	amod	Different,cohorts
R729	T982	T975	punct	", ",ANOVA
R7290	T9323	T9324	nsubj	cohorts,have
R7291	T9325	T9323	prep	of,cohorts
R7292	T9326	T9327	compound	C57BL,6J
R7293	T9327	T9329	compound	6J,mice
R7294	T9328	T9327	punct	/,6J
R7295	T9329	T9325	pobj	mice,of
R7296	T9330	T9331	dep	that,are
R7297	T9331	T9329	relcl	are,mice
R7298	T9332	T9331	acomp	homozygous,are
R7299	T9333	T9332	prep	for,homozygous
R73	T109	T108	compound	candidate,mutations
R730	T983	T975	acl	comparing,ANOVA
R7300	T9334	T9335	det	the,mutation
R7301	T9335	T9333	pobj	mutation,for
R7302	T9336	T9335	amod	spontaneous,mutation
R7303	T9337	T9338	compound	Tyrc,2J
R7304	T9338	T9335	compound	2J,mutation
R7305	T9339	T9338	punct	-,2J
R7306	T9340	T9341	amod	higher,IOP
R7307	T9341	T9324	dobj	IOP,have
R7308	T9342	T9341	prep	than,IOP
R7309	T9343	T9344	poss	their,counterparts
R731	T984	T983	dobj	strains,comparing
R7310	T9344	T9342	pobj	counterparts,than
R7311	T9345	T9344	amod	normal,counterparts
R7312	T9346	T9324	prep	at,have
R7313	T9347	T9348	det	all,ages
R7314	T9348	T9346	pobj	ages,at
R7315	T9349	T9348	amod	tested,ages
R7316	T9350	T9324	punct	.,have
R7317	T9352	T9353	det	All,groups
R7318	T9353	T9354	nsubj	groups,consisted
R7319	T9355	T9354	prep	of,consisted
R732	T985	T983	prep	within,comparing
R7320	T9356	T9357	amod	male,mice
R7321	T9357	T9355	pobj	mice,of
R7322	T9358	T9356	cc	and,male
R7323	T9359	T9356	conj	female,male
R7324	T9360	T9354	punct	.,consisted
R7325	T9363	T9362	punct	.,B
R7326	T9365	T9366	nsubjpass	IOP,increased
R7327	T9367	T9366	auxpass	is,increased
R7328	T9368	T9366	neg	not,increased
R7329	T9369	T9366	prep	during,increased
R733	T986	T987	det	each,group
R7330	T9370	T9371	det	the,period
R7331	T9371	T9369	pobj	period,during
R7332	T9372	T9371	amod	dark,period
R7333	T9373	T9371	prep	of,period
R7334	T9374	T9375	det	the,day
R7335	T9375	T9373	pobj	day,of
R7336	T9376	T9366	prep	in,increased
R7337	T9377	T9378	compound	Tyrc,2J
R7338	T9378	T9380	compound	2J,homozygotes
R7339	T9379	T9378	punct	-,2J
R734	T987	T985	pobj	group,within
R7340	T9380	T9376	pobj	homozygotes,in
R7341	T9381	T9366	punct	.,increased
R7342	T9383	T9384	det	The,number
R7343	T9384	T9385	nsubj	number,were
R7344	T9386	T9384	prep	of,number
R7345	T9387	T9386	pobj	mice,of
R7346	T9388	T9387	acl	analyzed,mice
R7347	T9389	T9388	prep	during,analyzed
R7348	T9390	T9391	det	the,period
R7349	T9391	T9389	pobj	period,during
R735	T988	T987	compound	sex,group
R7350	T9392	T9391	amod	light,period
R7351	T9393	T9385	punct	: ,were
R7352	T9394	T9395	nummod	2,month
R7353	T9395	T9385	attr	month,were
R7354	T9396	T9395	punct	", ",month
R7355	T9397	T9395	appos	28,month
R7356	T9398	T9397	punct	+,28
R7357	T9399	T9397	punct	/,28
R7358	T9400	T9397	punct	+,28
R7359	T9401	T9397	punct	", ",28
R736	T989	T975	punct	),ANOVA
R7360	T9402	T9403	nummod	29,c
R7361	T9403	T9397	appos	c,28
R7362	T9404	T9403	punct	-,c
R7363	T9405	T9406	compound	2J,c
R7364	T9406	T9403	appos	c,c
R7365	T9407	T9406	punct	/,c
R7366	T9408	T9403	punct	-,c
R7367	T9409	T9403	appos	2J,c
R7368	T9410	T9395	punct	", ",month
R7369	T9411	T9412	nummod	4,month
R737	T990	T970	punct	.,exist
R7370	T9412	T9395	appos	month,month
R7371	T9413	T9412	punct	", ",month
R7372	T9414	T9412	conj	20,month
R7373	T9415	T9414	punct	+,20
R7374	T9416	T9414	punct	/,20
R7375	T9417	T9414	punct	+,20
R7376	T9418	T9414	cc	and,20
R7377	T9419	T9420	nummod	20,c
R7378	T9420	T9414	conj	c,20
R7379	T9421	T9420	punct	-,c
R738	T992	T993	amod	Clinical,analysis
R7380	T9422	T9423	compound	2J,c
R7381	T9423	T9420	appos	c,c
R7382	T9424	T9423	punct	/,c
R7383	T9425	T9420	punct	-,c
R7384	T9426	T9420	appos	2J,c
R7385	T9427	T9395	punct	", ",month
R7386	T9428	T9429	nummod	8,month
R7387	T9429	T9395	appos	month,month
R7388	T9430	T9429	punct	", ",month
R7389	T9431	T9429	conj	15,month
R739	T993	T996	nsubj	analysis,identify
R7390	T9432	T9431	punct	+,15
R7391	T9433	T9431	punct	/,15
R7392	T9434	T9431	punct	+,15
R7393	T9435	T9431	cc	and,15
R7394	T9436	T9437	nummod	15,c
R7395	T9437	T9431	conj	c,15
R7396	T9438	T9437	punct	-,c
R7397	T9439	T9440	compound	2J,c
R7398	T9440	T9437	appos	c,c
R7399	T9441	T9440	punct	/,c
R74	T110	T108	compound	gene,mutations
R740	T994	T992	cc	and,Clinical
R7400	T9442	T9437	punct	-,c
R7401	T9443	T9437	appos	2J,c
R7402	T9444	T9385	punct	.,were
R7403	T9446	T9447	nummod	Fourteen,mice
R7404	T9447	T9448	nsubjpass	mice,analyzed
R7405	T9449	T9447	prep	of,mice
R7406	T9450	T9451	det	each,genotype
R7407	T9451	T9449	pobj	genotype,of
R7408	T9452	T9448	auxpass	were,analyzed
R7409	T9453	T9448	advmod	successfully,analyzed
R741	T995	T992	conj	histological,Clinical
R7410	T9454	T9448	prep	during,analyzed
R7411	T9455	T9456	det	the,period
R7412	T9456	T9454	pobj	period,during
R7413	T9457	T9456	amod	dark,period
R7414	T9458	T9456	prep	of,period
R7415	T9459	T9460	det	the,day
R7416	T9460	T9458	pobj	day,of
R7417	T9461	T9448	punct	.,analyzed
R7418	T9484	T9485	amod	Ocular,abnormalities
R7419	T9486	T9485	prep	in,abnormalities
R742	T997	T993	prep	of,analysis
R7420	T9487	T9488	amod	various,strains
R7421	T9488	T9486	pobj	strains,in
R743	T998	T999	det	the,eyes
R744	T999	T997	pobj	eyes,of
R745	T1000	T999	prep	of,eyes
R746	T1001	T1002	det	all,strains
R747	T1002	T1000	pobj	strains,of
R748	T1003	T1002	amod	studied,strains
R749	T1004	T1005	punct	(,see
R75	T111	T105	prep	on,effects
R750	T1005	T996	parataxis	see,identify
R751	T1006	T1005	dobj	Table,see
R752	T1007	T1006	nummod	1,Table
R753	T1008	T1005	punct	),see
R754	T1009	T996	aux	did,identify
R755	T1010	T996	neg	not,identify
R756	T1011	T1012	amod	anatomic,features
R757	T1012	T996	dobj	features,identify
R758	T1013	T1011	cc	or,anatomic
R759	T1014	T1011	conj	pathologic,anatomic
R76	T112	T111	pobj	IOP,on
R760	T1015	T1016	dep	that,account
R761	T1016	T1012	relcl	account,features
R762	T1017	T1016	aux	might,account
R763	T1018	T1016	prep	for,account
R764	T1019	T1020	det	the,differences
R765	T1020	T1018	pobj	differences,for
R766	T1021	T1020	prep	in,differences
R767	T1022	T1021	pobj	IOP,in
R768	T1023	T996	punct	.,identify
R769	T1025	T1026	prep	For,are
R77	T113	T66	punct	.,was
R770	T1027	T1025	pobj	example,For
R771	T1028	T1026	punct	", ",are
R772	T1029	T1030	det	the,angle
R773	T1030	T1026	nsubj	angle,are
R774	T1031	T1030	amod	iridocorneal,angle
R775	T1032	T1030	cc	and,angle
R776	T1033	T1034	amod	aqueous,humor
R777	T1034	T1035	compound	humor,drainage
R778	T1035	T1036	compound	drainage,structures
R779	T1036	T1030	conj	structures,angle
R78	T117	T118	prep	Based,ranges
R780	T1037	T1026	acomp	open,are
R781	T1038	T1037	prep	to,open
R782	T1039	T1040	det	the,chamber
R783	T1040	T1038	pobj	chamber,to
R784	T1041	T1040	amod	anterior,chamber
R785	T1042	T1026	cc	and,are
R786	T1043	T1026	conj	have,are
R787	T1044	T1045	amod	normal,morphology
R788	T1045	T1043	dobj	morphology,have
R789	T1046	T1043	prep	in,have
R79	T119	T117	prep	on,Based
R790	T1047	T1048	preconj	both,cJ
R791	T1048	T1051	nmod	cJ,mice
R792	T1049	T1048	nmod	BALB,cJ
R793	T1050	T1048	punct	/,cJ
R794	T1051	T1046	pobj	mice,in
R795	T1052	T1048	cc	and,cJ
R796	T1053	T1054	compound	CBA,CaJ
R797	T1054	T1048	conj	CaJ,cJ
R798	T1055	T1054	punct	/,CaJ
R799	T1056	T1057	punct	(,Figure
R8	T37	T31	det	an,update
R80	T120	T121	quantmod	over,30
R800	T1057	T1043	parataxis	Figure,have
R801	T1058	T1057	nummod	2,Figure
R802	T1059	T1057	punct	),Figure
R803	T1060	T1026	punct	.,are
R804	T1062	T1063	amod	More,20
R805	T1063	T1065	nummod	20,%
R806	T1064	T1063	quantmod	than,20
R807	T1065	T1066	nsubj	%,had
R808	T1067	T1065	prep	of,%
R809	T1068	T1069	compound	CBA,CaJ
R81	T121	T122	nummod	30,strains
R810	T1069	T1071	compound	CaJ,mice
R811	T1070	T1069	punct	/,CaJ
R812	T1071	T1067	pobj	mice,of
R813	T1072	T1066	dobj	IOPs,had
R814	T1073	T1072	prep	of,IOPs
R815	T1074	T1075	quantmod	over,21
R816	T1075	T1076	nummod	21,mmHg
R817	T1076	T1073	pobj	mmHg,of
R818	T1077	T1066	punct	", ",had
R819	T1078	T1079	dep	which,increases
R82	T122	T119	pobj	strains,on
R820	T1079	T1066	advcl	increases,had
R821	T1080	T1079	dobj	risk,increases
R822	T1081	T1080	prep	for,risk
R823	T1082	T1081	pobj	glaucoma,for
R824	T1083	T1079	prep	in,increases
R825	T1084	T1083	pobj	humans,in
R826	T1085	T1066	punct	.,had
R827	T1087	T1088	nsubj	We,aged
R828	T1089	T1090	det	a,group
R829	T1090	T1088	dobj	group,aged
R83	T123	T122	amod	studied,strains
R830	T1091	T1090	amod	small,group
R831	T1092	T1090	prep	of,group
R832	T1093	T1094	det	these,mice
R833	T1094	T1092	pobj	mice,of
R834	T1095	T1096	punct	(,4
R835	T1096	T1090	parataxis	4,group
R836	T1097	T1096	nsubj	n,4
R837	T1098	T1096	punct	=,4
R838	T1099	T1096	punct	),4
R839	T1100	T1088	prep	to,aged
R84	T124	T122	compound	mouse,strains
R840	T1101	T1102	nummod	2,years
R841	T1102	T1100	pobj	years,to
R842	T1103	T1088	cc	and,aged
R843	T1104	T1105	advmod	histologically,analyzed
R844	T1105	T1088	conj	analyzed,aged
R845	T1106	T1107	poss	their,nerves
R846	T1107	T1105	dobj	nerves,analyzed
R847	T1108	T1107	amod	optic,nerves
R848	T1109	T1107	cc	and,nerves
R849	T1110	T1107	conj	retinas,nerves
R85	T125	T118	punct	", ",ranges
R850	T1111	T1088	cc	but,aged
R851	T1112	T1113	nsubj	they,develop
R852	T1113	T1088	conj	develop,aged
R853	T1114	T1113	aux	did,develop
R854	T1115	T1113	neg	not,develop
R855	T1116	T1113	dobj	glaucoma,develop
R856	T1117	T1113	punct	.,develop
R857	T1150	T1151	compound	Strain,differences
R858	T1151	T1152	nsubj	differences,are
R859	T1153	T1152	acomp	reproducible,are
R86	T126	T127	amod	average,IOP
R860	T1155	T1156	aux	To,assess
R861	T1156	T1157	advcl	assess,measured
R862	T1158	T1159	det	the,consistency
R863	T1159	T1156	dobj	consistency,assess
R864	T1160	T1159	prep	of,consistency
R865	T1161	T1160	pobj	IOP,of
R866	T1162	T1156	prep	in,assess
R867	T1163	T1164	amod	specific,strains
R868	T1164	T1162	pobj	strains,in
R869	T1165	T1157	punct	", ",measured
R87	T127	T118	nsubj	IOP,ranges
R870	T1166	T1157	nsubj	we,measured
R871	T1167	T1157	dobj	IOP,measured
R872	T1168	T1157	prep	in,measured
R873	T1169	T1170	amod	different,cohorts
R874	T1170	T1168	pobj	cohorts,in
R875	T1171	T1170	prep	of,cohorts
R876	T1172	T1173	det	each,strain
R877	T1173	T1171	pobj	strain,of
R878	T1174	T1170	acl	maintained,cohorts
R879	T1175	T1174	prep	under,maintained
R88	T128	T118	prep	from,ranges
R880	T1176	T1177	amod	similar,conditions
R881	T1177	T1175	pobj	conditions,under
R882	T1178	T1174	prep	at,maintained
R883	T1179	T1180	amod	different,times
R884	T1180	T1178	pobj	times,at
R885	T1181	T1157	punct	.,measured
R886	T1183	T1184	nsubj	We,included
R887	T1185	T1184	advmod	purposefully,included
R888	T1186	T1184	dobj	strains,included
R889	T1187	T1186	prep	at,strains
R89	T129	T130	advmod	approximately,10
R890	T1188	T1189	det	each,end
R891	T1189	T1187	pobj	end,at
R892	T1190	T1189	prep	of,end
R893	T1191	T1192	det	the,spectrum
R894	T1192	T1190	pobj	spectrum,of
R895	T1193	T1192	compound	IOP,spectrum
R896	T1194	T1186	punct	", ",strains
R897	T1195	T1186	cc	and,strains
R898	T1196	T1197	compound	strain,6J
R899	T1197	T1186	conj	6J,strains
R9	T38	T31	cc	and,update
R90	T130	T128	pobj	10,from
R900	T1198	T1197	compound	C57BL,6J
R901	T1199	T1197	punct	/,6J
R902	T1200	T1197	punct	(,6J
R903	T1201	T1197	appos	B6,6J
R904	T1202	T1197	punct	),6J
R905	T1203	T1204	dep	that,used
R906	T1204	T1197	relcl	used,6J
R907	T1205	T1204	auxpass	is,used
R908	T1206	T1204	advmod	commonly,used
R909	T1207	T1204	prep	for,used
R91	T131	T128	prep	to,from
R910	T1208	T1209	amod	genetic,experiments
R911	T1209	T1207	pobj	experiments,for
R912	T1210	T1211	punct	(,Figure
R913	T1211	T1184	parataxis	Figure,included
R914	T1212	T1211	nummod	3,Figure
R915	T1213	T1211	punct	),Figure
R916	T1214	T1184	punct	.,included
R917	T1216	T1217	det	The,IOP
R918	T1217	T1219	nsubj	IOP,were
R919	T1218	T1217	amod	average,IOP
R92	T132	T131	pobj	20,to
R920	T1220	T1217	prep	of,IOP
R921	T1221	T1222	amod	different,cohorts
R922	T1222	T1220	pobj	cohorts,of
R923	T1223	T1222	prep	of,cohorts
R924	T1224	T1225	compound	strains,CaJ
R925	T1225	T1223	pobj	CaJ,of
R926	T1226	T1225	compound	CBA,CaJ
R927	T1227	T1225	punct	/,CaJ
R928	T1228	T1225	punct	", ",CaJ
R929	T1229	T1230	compound	CBA,CaHN
R93	T133	T128	pobj	mmHg,from
R930	T1230	T1225	appos	CaHN,CaJ
R931	T1231	T1230	punct	/,CaHN
R932	T1232	T1225	punct	(,CaJ
R933	T1233	T1225	appos	both,CaJ
R934	T1234	T1235	amod	high,end
R935	T1235	T1233	appos	end,both
R936	T1236	T1235	prep	of,end
R937	T1237	T1236	pobj	spectrum,of
R938	T1238	T1225	punct	),CaJ
R939	T1239	T1225	cc	and,CaJ
R94	T134	T118	punct	.,ranges
R940	T1240	T1225	conj	B6,CaJ
R941	T1241	T1219	acomp	consistent,were
R942	T1242	T1241	prep	over,consistent
R943	T1243	T1242	pobj	time,over
R944	T1244	T1219	punct	.,were
R945	T1246	T1247	nsubj	This,was
R946	T1248	T1247	acomp	true,was
R947	T1249	T1248	prep	of,true
R948	T1250	T1251	amod	most,strains
R949	T1251	T1249	pobj	strains,of
R95	T136	T137	nsubj	Gender,affect
R950	T1252	T1251	acl	assessed,strains
R951	T1253	T1252	prep	on,assessed
R952	T1254	T1255	amod	multiple,occasions
R953	T1255	T1253	pobj	occasions,on
R954	T1256	T1247	punct	.,was
R955	T1258	T1259	amod	Average,IOP
R956	T1259	T1260	nsubj	IOP,differed
R957	T1261	T1259	prep	for,IOP
R958	T1262	T1263	npadvmod	age,matched
R959	T1263	T1264	amod	matched,mice
R96	T138	T137	aux	does,affect
R960	T1264	T1261	pobj	mice,for
R961	T1265	T1264	prep	of,mice
R962	T1266	T1267	det	the,strain
R963	T1267	T1265	pobj	strain,of
R964	T1268	T1267	amod	same,strain
R965	T1269	T1267	acl	assessed,strain
R966	T1270	T1269	prep	at,assessed
R967	T1271	T1272	amod	different,times
R968	T1272	T1270	pobj	times,at
R969	T1273	T1260	advmod	typically,differed
R97	T139	T137	neg	not,affect
R970	T1274	T1260	prep	by,differed
R971	T1275	T1276	quantmod	no,1.5
R972	T1276	T1279	nummod	1.5,mmHg
R973	T1277	T1276	amod	more,1.5
R974	T1278	T1276	quantmod	than,1.5
R975	T1279	T1274	pobj	mmHg,by
R976	T1280	T1260	punct	", ",differed
R977	T1281	T1260	cc	and,differed
R978	T1282	T1283	det	the,differences
R979	T1283	T1284	nsubj	differences,were
R98	T140	T137	advmod	typically,affect
R980	T1284	T1260	conj	were,differed
R981	T1285	T1284	advmod	usually,were
R982	T1286	T1284	acomp	smaller,were
R983	T1287	T1284	punct	.,were
R984	T1289	T1290	compound	Strain,J
R985	T1290	T1293	nsubj	J,was
R986	T1291	T1290	compound	129P3,J
R987	T1292	T1290	punct	/,J
R988	T1294	T1295	det	the,strain
R989	T1295	T1293	attr	strain,was
R99	T141	T137	dobj	IOP,affect
R990	T1296	T1297	advmod	most,variable
R991	T1297	T1295	amod	variable,strain
R992	T1298	T1299	mark	with,fluctuating
R993	T1299	T1293	advcl	fluctuating,was
R994	T1300	T1301	det	the,IOP
R995	T1301	T1299	nsubj	IOP,fluctuating
R996	T1302	T1301	amod	average,IOP
R997	T1303	T1299	prep	by,fluctuating
R998	T1304	T1305	quantmod	up,2.5
R999	T1305	T1307	nummod	2.5,mmHg

PMC:48141 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

PMC:48141 JSON TXT 8 Projects