PMC:441373 / 2055-51368 JSON TXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id	Subject	Object	Predicate	Lexical cue
T703	11-14	DT	denotes	The
T704	15-24	NN	denotes	evolution
T706	25-27	IN	denotes	of
T707	28-35	JJ	denotes	complex
T708	36-45	NNS	denotes	organisms
T709	46-49	VBZ	denotes	has
T710	50-54	VBN	denotes	been
T705	55-65	VBN	denotes	associated
T711	66-70	IN	denotes	with
T712	71-74	DT	denotes	the
T713	75-85	NN	denotes	generation
T714	86-88	IN	denotes	of
T715	89-93	NN	denotes	gene
T716	94-102	NNS	denotes	families
T717	103-105	IN	denotes	by
T718	106-109	DT	denotes	the
T720	110-119	JJ	denotes	continual
T719	120-131	NN	denotes	duplication
T721	132-134	IN	denotes	of
T722	135-137	DT	denotes	an
T724	138-145	JJ	denotes	initial
T725	146-156	RB	denotes	relatively
T726	157-162	JJ	denotes	small
T723	163-166	NN	denotes	set
T727	167-169	IN	denotes	of
T728	170-179	JJ	denotes	ancestral
T729	180-185	NNS	denotes	genes
T730	185-186	.	denotes	.
T731	186-400	sentence	denotes	Through this process, followed by subsequent mutation, reduplication and exon shuffling between gene families, genes have evolved both discrete, and partially redundant functions with their related family members.
T732	187-194	IN	denotes	Through
T734	195-199	DT	denotes	this
T735	200-207	NN	denotes	process
T736	207-209	,	denotes	,
T737	209-217	VBN	denotes	followed
T738	218-220	IN	denotes	by
T739	221-231	JJ	denotes	subsequent
T740	232-240	NN	denotes	mutation
T741	240-242	,	denotes	,
T742	242-255	NN	denotes	reduplication
T743	256-259	CC	denotes	and
T744	260-264	NN	denotes	exon
T745	265-274	NN	denotes	shuffling
T746	275-282	IN	denotes	between
T747	283-287	NN	denotes	gene
T748	288-296	NNS	denotes	families
T749	296-298	,	denotes	,
T750	298-303	NNS	denotes	genes
T751	304-308	VBP	denotes	have
T733	309-316	VBN	denotes	evolved
T752	317-321	CC	denotes	both
T753	322-330	JJ	denotes	discrete
T755	330-332	,	denotes	,
T756	332-335	CC	denotes	and
T757	336-345	RB	denotes	partially
T758	346-355	JJ	denotes	redundant
T754	356-365	NNS	denotes	functions
T759	366-370	IN	denotes	with
T760	371-376	PRP$	denotes	their
T762	377-384	VBN	denotes	related
T763	385-391	NN	denotes	family
T761	392-399	NNS	denotes	members
T764	399-400	.	denotes	.
T765	400-625	sentence	denotes	With the completion of the genome sequencing projects of human, mouse, rat, fruit fly and nematodes, we are now in a position to ask fundamental questions in regard to how genes interact in the context of the whole organism.
T766	401-405	IN	denotes	With
T768	406-409	DT	denotes	the
T769	410-420	NN	denotes	completion
T770	421-423	IN	denotes	of
T771	424-427	DT	denotes	the
T773	428-434	NN	denotes	genome
T774	435-445	NN	denotes	sequencing
T772	446-454	NNS	denotes	projects
T775	455-457	IN	denotes	of
T776	458-463	JJ	denotes	human
T777	463-465	,	denotes	,
T778	465-470	NN	denotes	mouse
T779	470-472	,	denotes	,
T780	472-475	NN	denotes	rat
T781	475-477	,	denotes	,
T782	477-482	NN	denotes	fruit
T783	483-486	NN	denotes	fly
T784	487-490	CC	denotes	and
T785	491-500	NNS	denotes	nematodes
T786	500-502	,	denotes	,
T787	502-504	PRP	denotes	we
T767	505-508	VBP	denotes	are
T788	509-512	RB	denotes	now
T789	513-515	IN	denotes	in
T790	516-517	DT	denotes	a
T791	518-526	NN	denotes	position
T792	527-529	TO	denotes	to
T793	530-533	VB	denotes	ask
T794	534-545	JJ	denotes	fundamental
T795	546-555	NNS	denotes	questions
T796	556-558	IN	denotes	in
T797	559-565	NN	denotes	regard
T798	566-568	IN	denotes	to
T799	569-572	WRB	denotes	how
T801	573-578	NNS	denotes	genes
T800	579-587	VBP	denotes	interact
T802	588-590	IN	denotes	in
T803	591-594	DT	denotes	the
T804	595-602	NN	denotes	context
T805	603-605	IN	denotes	of
T806	606-609	DT	denotes	the
T808	610-615	JJ	denotes	whole
T807	616-624	NN	denotes	organism
T809	624-625	.	denotes	.
T810	625-809	sentence	denotes	Thus, with the appropriate application of bioinformatics, it is now possible to trace the lineage of particular genes and gene families, with related gene families in other organisms.
T811	626-630	RB	denotes	Thus
T813	630-632	,	denotes	,
T814	632-636	IN	denotes	with
T815	637-640	DT	denotes	the
T817	641-652	JJ	denotes	appropriate
T816	653-664	NN	denotes	application
T818	665-667	IN	denotes	of
T819	668-682	NN	denotes	bioinformatics
T820	682-684	,	denotes	,
T821	684-686	PRP	denotes	it
T812	687-689	VBZ	denotes	is
T822	690-693	RB	denotes	now
T823	694-702	JJ	denotes	possible
T824	703-705	TO	denotes	to
T825	706-711	VB	denotes	trace
T826	712-715	DT	denotes	the
T827	716-723	NN	denotes	lineage
T828	724-726	IN	denotes	of
T829	727-737	JJ	denotes	particular
T830	738-743	NNS	denotes	genes
T831	744-747	CC	denotes	and
T832	748-752	NN	denotes	gene
T833	753-761	NNS	denotes	families
T834	761-763	,	denotes	,
T835	763-767	IN	denotes	with
T836	768-775	JJ	denotes	related
T838	776-780	NN	denotes	gene
T837	781-789	NNS	denotes	families
T839	790-792	IN	denotes	in
T840	793-798	JJ	denotes	other
T841	799-808	NNS	denotes	organisms
T842	808-809	.	denotes	.
T843	809-1041	sentence	denotes	Furthermore, with the growing amount of large-scale proteomic and genomic data becoming publicly available, this analysis can now be extended to reveal the complex interplay between evolution of gene structure and protein function.
T844	810-821	RB	denotes	Furthermore
T846	821-823	,	denotes	,
T847	823-827	IN	denotes	with
T848	828-831	DT	denotes	the
T850	832-839	VBG	denotes	growing
T849	840-846	NN	denotes	amount
T852	847-849	IN	denotes	of
T853	850-855	JJ	denotes	large
T855	855-856	HYPH	denotes	-
T854	856-861	NN	denotes	scale
T857	862-871	JJ	denotes	proteomic
T858	872-875	CC	denotes	and
T859	876-883	JJ	denotes	genomic
T856	884-888	NNS	denotes	data
T851	889-897	VBG	denotes	becoming
T860	898-906	RB	denotes	publicly
T861	907-916	JJ	denotes	available
T862	916-918	,	denotes	,
T863	918-922	DT	denotes	this
T864	923-931	NN	denotes	analysis
T865	932-935	MD	denotes	can
T866	936-939	RB	denotes	now
T867	940-942	VB	denotes	be
T845	943-951	VBN	denotes	extended
T868	952-954	TO	denotes	to
T869	955-961	VB	denotes	reveal
T870	962-965	DT	denotes	the
T872	966-973	JJ	denotes	complex
T871	974-983	NN	denotes	interplay
T873	984-991	IN	denotes	between
T874	992-1001	NN	denotes	evolution
T875	1002-1004	IN	denotes	of
T876	1005-1009	NN	denotes	gene
T877	1010-1019	NN	denotes	structure
T878	1020-1023	CC	denotes	and
T879	1024-1031	NN	denotes	protein
T880	1032-1040	NN	denotes	function
T881	1040-1041	.	denotes	.
T882	1041-1208	sentence	denotes	The first Transforming acidic coiled coil gene, TACC1, was identified during the development of an expression map of the proximal short arm of human chromosome 8 [1].
T883	1042-1045	DT	denotes	The
T885	1046-1051	JJ	denotes	first
T886	1052-1064	NN	denotes	Transforming
T887	1065-1071	JJ	denotes	acidic
T888	1072-1078	VBN	denotes	coiled
T889	1079-1083	NN	denotes	coil
T884	1084-1088	NN	denotes	gene
T891	1088-1090	,	denotes	,
T892	1090-1095	NN	denotes	TACC1
T893	1095-1097	,	denotes	,
T894	1097-1100	VBD	denotes	was
T890	1101-1111	VBN	denotes	identified
T895	1112-1118	IN	denotes	during
T896	1119-1122	DT	denotes	the
T897	1123-1134	NN	denotes	development
T898	1135-1137	IN	denotes	of
T899	1138-1140	DT	denotes	an
T901	1141-1151	NN	denotes	expression
T900	1152-1155	NN	denotes	map
T902	1156-1158	IN	denotes	of
T903	1159-1162	DT	denotes	the
T905	1163-1171	JJ	denotes	proximal
T906	1172-1177	JJ	denotes	short
T904	1178-1181	NN	denotes	arm
T907	1182-1184	IN	denotes	of
T908	1185-1190	JJ	denotes	human
T909	1191-1201	NN	denotes	chromosome
T910	1202-1203	CD	denotes	8
T911	1204-1205	-LRB-	denotes	[
T912	1205-1206	CD	denotes	1
T913	1206-1207	-RRB-	denotes	]
T914	1207-1208	.	denotes	.
T915	1208-1413	sentence	denotes	Two additional TACC family members were subsequently identified and mapped to paralogous chromosomal regions on human chromosomes 4p16 and 10q26, physically close to members of the FGFR gene family [1-3].
T916	1209-1212	CD	denotes	Two
T918	1213-1223	JJ	denotes	additional
T919	1224-1228	NN	denotes	TACC
T920	1229-1235	NN	denotes	family
T917	1236-1243	NNS	denotes	members
T922	1244-1248	VBD	denotes	were
T923	1249-1261	RB	denotes	subsequently
T921	1262-1272	VBN	denotes	identified
T924	1273-1276	CC	denotes	and
T925	1277-1283	VBN	denotes	mapped
T926	1284-1286	IN	denotes	to
T927	1287-1297	JJ	denotes	paralogous
T929	1298-1309	JJ	denotes	chromosomal
T928	1310-1317	NNS	denotes	regions
T930	1318-1320	IN	denotes	on
T931	1321-1326	JJ	denotes	human
T933	1327-1338	NNS	denotes	chromosomes
T932	1339-1343	NN	denotes	4p16
T934	1344-1347	CC	denotes	and
T935	1348-1353	NN	denotes	10q26
T936	1353-1355	,	denotes	,
T937	1355-1365	RB	denotes	physically
T938	1366-1371	JJ	denotes	close
T939	1372-1374	IN	denotes	to
T940	1375-1382	NNS	denotes	members
T941	1383-1385	IN	denotes	of
T942	1386-1389	DT	denotes	the
T944	1390-1394	NN	denotes	FGFR
T945	1395-1399	NN	denotes	gene
T943	1400-1406	NN	denotes	family
T946	1407-1408	-LRB-	denotes	[
T947	1408-1409	CD	denotes	1
T948	1409-1410	SYM	denotes	-
T949	1410-1411	CD	denotes	3
T950	1411-1412	-RRB-	denotes	]
T951	1412-1413	.	denotes	.
T952	1413-1667	sentence	denotes	This mapping data, together with identification of a single TACC gene in the protostomes Caenorhabitis elegans, and Drosophila melanogaster [4-6], led to the speculation that the ancestral FGFR and TACC genes were located physically close to each other.
T953	1414-1418	DT	denotes	This
T955	1419-1426	NN	denotes	mapping
T954	1427-1431	NNS	denotes	data
T957	1431-1433	,	denotes	,
T958	1433-1441	RB	denotes	together
T959	1442-1446	IN	denotes	with
T960	1447-1461	NN	denotes	identification
T961	1462-1464	IN	denotes	of
T962	1465-1466	DT	denotes	a
T964	1467-1473	JJ	denotes	single
T965	1474-1478	NN	denotes	TACC
T963	1479-1483	NN	denotes	gene
T966	1484-1486	IN	denotes	in
T967	1487-1490	DT	denotes	the
T969	1491-1502	NNS	denotes	protostomes
T970	1503-1516	NNP	denotes	Caenorhabitis
T968	1517-1524	NNP	denotes	elegans
T971	1524-1526	,	denotes	,
T972	1526-1529	CC	denotes	and
T973	1530-1540	NNP	denotes	Drosophila
T974	1541-1553	NNP	denotes	melanogaster
T975	1554-1555	-LRB-	denotes	[
T976	1555-1556	CD	denotes	4
T977	1556-1557	SYM	denotes	-
T978	1557-1558	CD	denotes	6
T979	1558-1559	-RRB-	denotes	]
T980	1559-1561	,	denotes	,
T956	1561-1564	VBD	denotes	led
T981	1565-1567	IN	denotes	to
T982	1568-1571	DT	denotes	the
T983	1572-1583	NN	denotes	speculation
T984	1584-1588	IN	denotes	that
T986	1589-1592	DT	denotes	the
T988	1593-1602	JJ	denotes	ancestral
T989	1603-1607	NN	denotes	FGFR
T990	1608-1611	CC	denotes	and
T991	1612-1616	NN	denotes	TACC
T987	1617-1622	NNS	denotes	genes
T992	1623-1627	VBD	denotes	were
T985	1628-1635	VBN	denotes	located
T993	1636-1646	RB	denotes	physically
T994	1647-1652	RB	denotes	close
T995	1653-1655	IN	denotes	to
T996	1656-1660	DT	denotes	each
T997	1661-1666	JJ	denotes	other
T998	1666-1667	.	denotes	.
T999	1667-1859	sentence	denotes	Thus, during the evolution of vertebrates, subsequent successive duplications of the ancestral gene cluster have given rise to three TACC family members located close to FGFR genes in humans.
T1000	1668-1672	RB	denotes	Thus
T1002	1672-1674	,	denotes	,
T1003	1674-1680	IN	denotes	during
T1004	1681-1684	DT	denotes	the
T1005	1685-1694	NN	denotes	evolution
T1006	1695-1697	IN	denotes	of
T1007	1698-1709	NNS	denotes	vertebrates
T1008	1709-1711	,	denotes	,
T1009	1711-1721	JJ	denotes	subsequent
T1011	1722-1732	JJ	denotes	successive
T1010	1733-1745	NNS	denotes	duplications
T1012	1746-1748	IN	denotes	of
T1013	1749-1752	DT	denotes	the
T1015	1753-1762	JJ	denotes	ancestral
T1016	1763-1767	NN	denotes	gene
T1014	1768-1775	NN	denotes	cluster
T1017	1776-1780	VBP	denotes	have
T1001	1781-1786	VBN	denotes	given
T1018	1787-1791	NN	denotes	rise
T1019	1792-1794	IN	denotes	to
T1020	1795-1800	CD	denotes	three
T1022	1801-1805	NN	denotes	TACC
T1023	1806-1812	NN	denotes	family
T1021	1813-1820	NNS	denotes	members
T1024	1821-1828	VBN	denotes	located
T1025	1829-1834	RB	denotes	close
T1026	1835-1837	IN	denotes	to
T1027	1838-1842	NN	denotes	FGFR
T1028	1843-1848	NNS	denotes	genes
T1029	1849-1851	IN	denotes	in
T1030	1852-1858	NNS	denotes	humans
T1031	1858-1859	.	denotes	.
T1032	1859-2102	sentence	denotes	In accordance with the proposed quadruplication of the vertebrate genome during evolution, there is a fourth FGFR family member in vertebrates, raising the question of whether a fourth TACC gene is associated with FGFR4 in vertebrate genomes.
T1033	1860-1862	IN	denotes	In
T1035	1863-1873	NN	denotes	accordance
T1036	1874-1878	IN	denotes	with
T1037	1879-1882	DT	denotes	the
T1039	1883-1891	VBN	denotes	proposed
T1038	1892-1907	NN	denotes	quadruplication
T1040	1908-1910	IN	denotes	of
T1041	1911-1914	DT	denotes	the
T1043	1915-1925	NN	denotes	vertebrate
T1042	1926-1932	NN	denotes	genome
T1044	1933-1939	IN	denotes	during
T1045	1940-1949	NN	denotes	evolution
T1046	1949-1951	,	denotes	,
T1047	1951-1956	EX	denotes	there
T1034	1957-1959	VBZ	denotes	is
T1048	1960-1961	DT	denotes	a
T1050	1962-1968	JJ	denotes	fourth
T1051	1969-1973	NN	denotes	FGFR
T1052	1974-1980	NN	denotes	family
T1049	1981-1987	NN	denotes	member
T1053	1988-1990	IN	denotes	in
T1054	1991-2002	NNS	denotes	vertebrates
T1055	2002-2004	,	denotes	,
T1056	2004-2011	VBG	denotes	raising
T1057	2012-2015	DT	denotes	the
T1058	2016-2024	NN	denotes	question
T1059	2025-2027	IN	denotes	of
T1060	2028-2035	IN	denotes	whether
T1062	2036-2037	DT	denotes	a
T1064	2038-2044	JJ	denotes	fourth
T1065	2045-2049	NN	denotes	TACC
T1063	2050-2054	NN	denotes	gene
T1066	2055-2057	VBZ	denotes	is
T1061	2058-2068	VBN	denotes	associated
T1067	2069-2073	IN	denotes	with
T1068	2074-2079	NN	denotes	FGFR4
T1069	2080-2082	IN	denotes	in
T1070	2083-2093	NN	denotes	vertebrate
T1071	2094-2101	NNS	denotes	genomes
T1072	2101-2102	.	denotes	.
T1073	2102-2263	sentence	denotes	To date, only three active TACC genes have been cloned in humans [1-3], one in each of mouse [7], Xenopus laevis [8], D. melanogaster [4], and C. elegans [5,6].
T1074	2103-2105	IN	denotes	To
T1076	2106-2110	NN	denotes	date
T1077	2110-2112	,	denotes	,
T1078	2112-2116	RB	denotes	only
T1080	2117-2122	CD	denotes	three
T1081	2123-2129	JJ	denotes	active
T1082	2130-2134	NN	denotes	TACC
T1079	2135-2140	NNS	denotes	genes
T1084	2141-2145	VBP	denotes	have
T1085	2146-2150	VBN	denotes	been
T1083	2151-2157	VBN	denotes	cloned
T1086	2158-2160	IN	denotes	in
T1087	2161-2167	NNS	denotes	humans
T1088	2168-2169	-LRB-	denotes	[
T1089	2169-2170	CD	denotes	1
T1090	2170-2171	SYM	denotes	-
T1091	2171-2172	CD	denotes	3
T1092	2172-2173	-RRB-	denotes	]
T1093	2173-2175	,	denotes	,
T1075	2175-2178	CD	denotes	one
T1094	2179-2181	IN	denotes	in
T1095	2182-2186	DT	denotes	each
T1096	2187-2189	IN	denotes	of
T1097	2190-2195	NN	denotes	mouse
T1098	2196-2197	-LRB-	denotes	[
T1099	2197-2198	CD	denotes	7
T1100	2198-2199	-RRB-	denotes	]
T1101	2199-2201	,	denotes	,
T1102	2201-2208	NNP	denotes	Xenopus
T1103	2209-2215	NNP	denotes	laevis
T1104	2216-2217	-LRB-	denotes	[
T1105	2217-2218	CD	denotes	8
T1106	2218-2219	-RRB-	denotes	]
T1107	2219-2221	,	denotes	,
T1108	2221-2223	NNP	denotes	D.
T1109	2224-2236	NNP	denotes	melanogaster
T1110	2237-2238	-LRB-	denotes	[
T1111	2238-2239	CD	denotes	4
T1112	2239-2240	-RRB-	denotes	]
T1113	2240-2242	,	denotes	,
T1114	2242-2245	CC	denotes	and
T1115	2246-2248	NNP	denotes	C.
T1116	2249-2256	NNP	denotes	elegans
T1117	2257-2258	-LRB-	denotes	[
T1119	2258-2259	CD	denotes	5
T1120	2259-2260	,	denotes	,
T1118	2260-2261	CD	denotes	6
T1121	2261-2262	-RRB-	denotes	]
T1122	2262-2263	.	denotes	.
T1123	2263-2482	sentence	denotes	Although two additional new candidate TACC family members, Oryctolagus cuniculus TACC4 [9] and human RHAMM [10] have been proposed, their true identity and placement in the evolution of the TACC family is under debate.
T1124	2264-2272	IN	denotes	Although
T1126	2273-2276	CD	denotes	two
T1128	2277-2287	JJ	denotes	additional
T1129	2288-2291	JJ	denotes	new
T1130	2292-2301	NN	denotes	candidate
T1131	2302-2306	NN	denotes	TACC
T1132	2307-2313	NN	denotes	family
T1127	2314-2321	NNS	denotes	members
T1133	2321-2323	,	denotes	,
T1134	2323-2334	NNP	denotes	Oryctolagus
T1136	2335-2344	NNP	denotes	cuniculus
T1135	2345-2350	NN	denotes	TACC4
T1137	2351-2352	-LRB-	denotes	[
T1138	2352-2353	CD	denotes	9
T1139	2353-2354	-RRB-	denotes	]
T1140	2355-2358	CC	denotes	and
T1141	2359-2364	JJ	denotes	human
T1142	2365-2370	NN	denotes	RHAMM
T1143	2371-2372	-LRB-	denotes	[
T1144	2372-2374	CD	denotes	10
T1145	2374-2375	-RRB-	denotes	]
T1146	2376-2380	VBP	denotes	have
T1147	2381-2385	VBN	denotes	been
T1125	2386-2394	VBN	denotes	proposed
T1149	2394-2396	,	denotes	,
T1150	2396-2401	PRP$	denotes	their
T1152	2402-2406	JJ	denotes	true
T1151	2407-2415	NN	denotes	identity
T1153	2416-2419	CC	denotes	and
T1154	2420-2429	NN	denotes	placement
T1155	2430-2432	IN	denotes	in
T1156	2433-2436	DT	denotes	the
T1157	2437-2446	NN	denotes	evolution
T1158	2447-2449	IN	denotes	of
T1159	2450-2453	DT	denotes	the
T1161	2454-2458	NN	denotes	TACC
T1160	2459-2465	NN	denotes	family
T1148	2466-2468	VBZ	denotes	is
T1162	2469-2474	IN	denotes	under
T1163	2475-2481	NN	denotes	debate
T1164	2481-2482	.	denotes	.
T1165	2482-2834	sentence	denotes	Thus, the identification and functional characterization of new members of the TACC family in other organisms, alternatively spliced isoforms of each TACC and comparison of the phylogenetic relationship of these genes relative to other members of the coiled coil superfamily will resolve this issue and provide clues to the evolution of TACC function.
T1166	2483-2487	RB	denotes	Thus
T1168	2487-2489	,	denotes	,
T1169	2489-2492	DT	denotes	the
T1170	2493-2507	NN	denotes	identification
T1171	2508-2511	CC	denotes	and
T1172	2512-2522	JJ	denotes	functional
T1173	2523-2539	NN	denotes	characterization
T1174	2540-2542	IN	denotes	of
T1175	2543-2546	JJ	denotes	new
T1176	2547-2554	NNS	denotes	members
T1177	2555-2557	IN	denotes	of
T1178	2558-2561	DT	denotes	the
T1180	2562-2566	NN	denotes	TACC
T1179	2567-2573	NN	denotes	family
T1181	2574-2576	IN	denotes	in
T1182	2577-2582	JJ	denotes	other
T1183	2583-2592	NNS	denotes	organisms
T1184	2592-2594	,	denotes	,
T1185	2594-2607	RB	denotes	alternatively
T1186	2608-2615	VBN	denotes	spliced
T1187	2616-2624	NNS	denotes	isoforms
T1188	2625-2627	IN	denotes	of
T1189	2628-2632	DT	denotes	each
T1190	2633-2637	NN	denotes	TACC
T1191	2638-2641	CC	denotes	and
T1192	2642-2652	NN	denotes	comparison
T1193	2653-2655	IN	denotes	of
T1194	2656-2659	DT	denotes	the
T1196	2660-2672	JJ	denotes	phylogenetic
T1195	2673-2685	NN	denotes	relationship
T1197	2686-2688	IN	denotes	of
T1198	2689-2694	DT	denotes	these
T1199	2695-2700	NNS	denotes	genes
T1200	2701-2709	JJ	denotes	relative
T1201	2710-2712	IN	denotes	to
T1202	2713-2718	JJ	denotes	other
T1203	2719-2726	NNS	denotes	members
T1204	2727-2729	IN	denotes	of
T1205	2730-2733	DT	denotes	the
T1207	2734-2740	VBN	denotes	coiled
T1208	2741-2745	NN	denotes	coil
T1206	2746-2757	NN	denotes	superfamily
T1209	2758-2762	MD	denotes	will
T1167	2763-2770	VB	denotes	resolve
T1210	2771-2775	DT	denotes	this
T1211	2776-2781	NN	denotes	issue
T1212	2782-2785	CC	denotes	and
T1213	2786-2793	VB	denotes	provide
T1214	2794-2799	NNS	denotes	clues
T1215	2800-2802	IN	denotes	to
T1216	2803-2806	DT	denotes	the
T1217	2807-2816	NN	denotes	evolution
T1218	2817-2819	IN	denotes	of
T1219	2820-2824	NN	denotes	TACC
T1220	2825-2833	NN	denotes	function
T1221	2833-2834	.	denotes	.
T1593	2860-2862	FW	denotes	In
T1594	2863-2869	FW	denotes	silico
T1595	2870-2884	NN	denotes	identification
T1596	2885-2887	IN	denotes	of
T1597	2888-2892	NN	denotes	TACC
T1599	2893-2899	NN	denotes	family
T1598	2900-2907	NNS	denotes	members
T1600	2908-2912	IN	denotes	from
T1601	2913-2923	NN	denotes	vertebrate
T1603	2924-2927	CC	denotes	and
T1604	2928-2940	NN	denotes	invertebrate
T1602	2941-2949	NNS	denotes	lineages
T1605	2949-3198	sentence	denotes	Sequence similarity searches of the publicly available genome databases with the BLAST and TBLAST programs were performed to identify TACC and RHAMM orthologues, and other members of the coiled coil superfamily in a diverse set of species (Fig. 1).
T1606	2950-2958	NN	denotes	Sequence
T1607	2959-2969	NN	denotes	similarity
T1608	2970-2978	NNS	denotes	searches
T1610	2979-2981	IN	denotes	of
T1611	2982-2985	DT	denotes	the
T1613	2986-2994	RB	denotes	publicly
T1614	2995-3004	JJ	denotes	available
T1615	3005-3011	NN	denotes	genome
T1612	3012-3021	NNS	denotes	databases
T1616	3022-3026	IN	denotes	with
T1617	3027-3030	DT	denotes	the
T1619	3031-3036	NN	denotes	BLAST
T1620	3037-3040	CC	denotes	and
T1621	3041-3047	NN	denotes	TBLAST
T1618	3048-3056	NNS	denotes	programs
T1622	3057-3061	VBD	denotes	were
T1609	3062-3071	VBN	denotes	performed
T1623	3072-3074	TO	denotes	to
T1624	3075-3083	VB	denotes	identify
T1625	3084-3088	NN	denotes	TACC
T1627	3089-3092	CC	denotes	and
T1628	3093-3098	NN	denotes	RHAMM
T1626	3099-3110	NNS	denotes	orthologues
T1629	3110-3112	,	denotes	,
T1630	3112-3115	CC	denotes	and
T1631	3116-3121	JJ	denotes	other
T1632	3122-3129	NNS	denotes	members
T1633	3130-3132	IN	denotes	of
T1634	3133-3136	DT	denotes	the
T1636	3137-3143	VBN	denotes	coiled
T1637	3144-3148	NN	denotes	coil
T1635	3149-3160	NN	denotes	superfamily
T1638	3161-3163	IN	denotes	in
T1639	3164-3165	DT	denotes	a
T1641	3166-3173	JJ	denotes	diverse
T1640	3174-3177	NN	denotes	set
T1642	3178-3180	IN	denotes	of
T1643	3181-3188	NNS	denotes	species
T1644	3189-3190	-LRB-	denotes	(
T1645	3190-3194	NN	denotes	Fig.
T1646	3195-3196	CD	denotes	1
T1647	3196-3197	-RRB-	denotes	)
T1648	3197-3198	.	denotes	.
T1649	3198-3321	sentence	denotes	This identified the complete sequence of the TACC genes in representatives of five major phylogenetically distinct clades.
T1650	3199-3203	DT	denotes	This
T1651	3204-3214	VBD	denotes	identified
T1652	3215-3218	DT	denotes	the
T1654	3219-3227	JJ	denotes	complete
T1653	3228-3236	NN	denotes	sequence
T1655	3237-3239	IN	denotes	of
T1656	3240-3243	DT	denotes	the
T1658	3244-3248	NN	denotes	TACC
T1657	3249-3254	NNS	denotes	genes
T1659	3255-3257	IN	denotes	in
T1660	3258-3273	NNS	denotes	representatives
T1661	3274-3276	IN	denotes	of
T1662	3277-3281	CD	denotes	five
T1664	3282-3287	JJ	denotes	major
T1665	3288-3304	RB	denotes	phylogenetically
T1666	3305-3313	JJ	denotes	distinct
T1663	3314-3320	NNS	denotes	clades
T1667	3320-3321	.	denotes	.
T1668	3321-3455	sentence	denotes	Where possible, the construction of the TACC sequences from these organisms was also confirmed by the analysis of the cDNA databases.
T1669	3322-3327	WRB	denotes	Where
T1670	3328-3336	JJ	denotes	possible
T1672	3336-3338	,	denotes	,
T1673	3338-3341	DT	denotes	the
T1674	3342-3354	NN	denotes	construction
T1675	3355-3357	IN	denotes	of
T1676	3358-3361	DT	denotes	the
T1678	3362-3366	NN	denotes	TACC
T1677	3367-3376	NNS	denotes	sequences
T1679	3377-3381	IN	denotes	from
T1680	3382-3387	DT	denotes	these
T1681	3388-3397	NNS	denotes	organisms
T1682	3398-3401	VBD	denotes	was
T1683	3402-3406	RB	denotes	also
T1671	3407-3416	VBN	denotes	confirmed
T1684	3417-3419	IN	denotes	by
T1685	3420-3423	DT	denotes	the
T1686	3424-3432	NN	denotes	analysis
T1687	3433-3435	IN	denotes	of
T1688	3436-3439	DT	denotes	the
T1690	3440-3444	NN	denotes	cDNA
T1689	3445-3454	NNS	denotes	databases
T1691	3454-3455	.	denotes	.
T1692	3455-3699	sentence	denotes	Several partial sequences in other vertebrate species, the echinodermate Strongylocentrotus purpuratus and the protostome insect Anopheles gambiae were also identified, suggesting an ancient conservation of the TACC genes in metazoan lineages.
T1693	3456-3463	JJ	denotes	Several
T1695	3464-3471	JJ	denotes	partial
T1694	3472-3481	NNS	denotes	sequences
T1697	3482-3484	IN	denotes	in
T1698	3485-3490	JJ	denotes	other
T1700	3491-3501	NN	denotes	vertebrate
T1699	3502-3509	NNS	denotes	species
T1701	3509-3511	,	denotes	,
T1702	3511-3514	DT	denotes	the
T1703	3515-3528	JJ	denotes	echinodermate
T1704	3529-3547	NNP	denotes	Strongylocentrotus
T1705	3548-3558	NNP	denotes	purpuratus
T1706	3559-3562	CC	denotes	and
T1707	3563-3566	DT	denotes	the
T1709	3567-3577	NN	denotes	protostome
T1708	3578-3584	NN	denotes	insect
T1710	3585-3594	NNP	denotes	Anopheles
T1711	3595-3602	NNP	denotes	gambiae
T1712	3603-3607	VBD	denotes	were
T1713	3608-3612	RB	denotes	also
T1696	3613-3623	VBN	denotes	identified
T1714	3623-3625	,	denotes	,
T1715	3625-3635	VBG	denotes	suggesting
T1716	3636-3638	DT	denotes	an
T1718	3639-3646	JJ	denotes	ancient
T1717	3647-3659	NN	denotes	conservation
T1719	3660-3662	IN	denotes	of
T1720	3663-3666	DT	denotes	the
T1722	3667-3671	NN	denotes	TACC
T1721	3672-3677	NNS	denotes	genes
T1723	3678-3680	IN	denotes	in
T1724	3681-3689	NN	denotes	metazoan
T1725	3690-3698	NNS	denotes	lineages
T1726	3698-3699	.	denotes	.
T1727	3699-3863	sentence	denotes	However, due to the relative infancy of the cDNA/genome projects for these latter organisms, complete characterization of these TACC genes could not be undertaken.
T1728	3700-3707	RB	denotes	However
T1730	3707-3709	,	denotes	,
T1731	3709-3712	IN	denotes	due
T1732	3713-3715	IN	denotes	to
T1733	3716-3719	DT	denotes	the
T1735	3720-3728	JJ	denotes	relative
T1734	3729-3736	NN	denotes	infancy
T1736	3737-3739	IN	denotes	of
T1737	3740-3743	DT	denotes	the
T1739	3744-3748	NN	denotes	cDNA
T1741	3748-3749	HYPH	denotes	/
T1740	3749-3755	NN	denotes	genome
T1738	3756-3764	NNS	denotes	projects
T1742	3765-3768	IN	denotes	for
T1743	3769-3774	DT	denotes	these
T1745	3775-3781	JJ	denotes	latter
T1744	3782-3791	NNS	denotes	organisms
T1746	3791-3793	,	denotes	,
T1747	3793-3801	JJ	denotes	complete
T1748	3802-3818	NN	denotes	characterization
T1749	3819-3821	IN	denotes	of
T1750	3822-3827	DT	denotes	these
T1752	3828-3832	NN	denotes	TACC
T1751	3833-3838	NNS	denotes	genes
T1753	3839-3844	MD	denotes	could
T1754	3845-3848	RB	denotes	not
T1755	3849-3851	VB	denotes	be
T1729	3852-3862	VBN	denotes	undertaken
T1756	3862-3863	.	denotes	.
T1757	3863-4171	sentence	denotes	No conclusion could be made about the existence of TACC-like sequence in non-bilaterian metazoans, such as Cnidaria or Porifera, due to the paucity of sequence information for these organisms, and additional definitive sequences with a defined TACC domain could not be found in other non-metazoan organisms.
T1758	3864-3866	DT	denotes	No
T1759	3867-3877	NN	denotes	conclusion
T1761	3878-3883	MD	denotes	could
T1762	3884-3886	VB	denotes	be
T1760	3887-3891	VBN	denotes	made
T1763	3892-3897	IN	denotes	about
T1764	3898-3901	DT	denotes	the
T1765	3902-3911	NN	denotes	existence
T1766	3912-3914	IN	denotes	of
T1767	3915-3919	NN	denotes	TACC
T1769	3919-3920	HYPH	denotes	-
T1768	3920-3924	JJ	denotes	like
T1770	3925-3933	NN	denotes	sequence
T1771	3934-3936	IN	denotes	in
T1772	3937-3951	JJ	denotes	non-bilaterian
T1773	3952-3961	NNS	denotes	metazoans
T1774	3961-3963	,	denotes	,
T1775	3963-3967	JJ	denotes	such
T1776	3968-3970	IN	denotes	as
T1777	3971-3979	NNP	denotes	Cnidaria
T1778	3980-3982	CC	denotes	or
T1779	3983-3991	NNP	denotes	Porifera
T1780	3991-3993	,	denotes	,
T1781	3993-3996	IN	denotes	due
T1782	3997-3999	IN	denotes	to
T1783	4000-4003	DT	denotes	the
T1784	4004-4011	NN	denotes	paucity
T1785	4012-4014	IN	denotes	of
T1786	4015-4023	NN	denotes	sequence
T1787	4024-4035	NN	denotes	information
T1788	4036-4039	IN	denotes	for
T1789	4040-4045	DT	denotes	these
T1790	4046-4055	NNS	denotes	organisms
T1791	4055-4057	,	denotes	,
T1792	4057-4060	CC	denotes	and
T1793	4061-4071	JJ	denotes	additional
T1795	4072-4082	JJ	denotes	definitive
T1794	4083-4092	NNS	denotes	sequences
T1797	4093-4097	IN	denotes	with
T1798	4098-4099	DT	denotes	a
T1800	4100-4107	VBN	denotes	defined
T1801	4108-4112	NN	denotes	TACC
T1799	4113-4119	NN	denotes	domain
T1802	4120-4125	MD	denotes	could
T1803	4126-4129	RB	denotes	not
T1804	4130-4132	VB	denotes	be
T1796	4133-4138	VBN	denotes	found
T1805	4139-4141	IN	denotes	in
T1806	4142-4147	JJ	denotes	other
T1808	4148-4160	JJ	denotes	non-metazoan
T1807	4161-4170	NNS	denotes	organisms
T1809	4170-4171	.	denotes	.
T1810	4171-4172	sentence	denotes
T12469	4182-4194	JJ	denotes	Phylogenetic
T12470	4195-4203	NN	denotes	analysis
T12471	4204-4206	IN	denotes	of
T12472	4207-4210	DT	denotes	the
T12474	4211-4215	NN	denotes	TACC
T12475	4216-4222	NN	denotes	family
T12473	4223-4230	NNS	denotes	members
T12476	4231-4239	VBN	denotes	compared
T12477	4240-4242	IN	denotes	to
T12478	4243-4248	JJ	denotes	other
T12480	4249-4255	VBN	denotes	coiled
T12481	4256-4260	NN	denotes	coil
T12479	4261-4269	NN	denotes	proteins
T12482	4269-4270	.	denotes	.
T12483	4270-4345	sentence	denotes	The phylogenetic tree was constructed as described in the Methods section.
T12484	4271-4274	DT	denotes	The
T12486	4275-4287	JJ	denotes	phylogenetic
T12485	4288-4292	NN	denotes	tree
T12488	4293-4296	VBD	denotes	was
T12487	4297-4308	VBN	denotes	constructed
T12489	4309-4311	IN	denotes	as
T12490	4312-4321	VBN	denotes	described
T12491	4322-4324	IN	denotes	in
T12492	4325-4328	DT	denotes	the
T12494	4329-4336	NNS	denotes	Methods
T12493	4337-4344	NN	denotes	section
T12495	4344-4345	.	denotes	.
T12496	4345-4513	sentence	denotes	The TACC family defines a separate subfamily of coiled coil containing proteins, distinct from other coiled coil families such as the keratins, RHAMM and tropomyosins.
T12497	4346-4349	DT	denotes	The
T12499	4350-4354	NN	denotes	TACC
T12498	4355-4361	NN	denotes	family
T12500	4362-4369	VBZ	denotes	defines
T12501	4370-4371	DT	denotes	a
T12503	4372-4380	JJ	denotes	separate
T12502	4381-4390	NN	denotes	subfamily
T12504	4391-4393	IN	denotes	of
T12505	4394-4400	VBN	denotes	coiled
T12506	4401-4405	NN	denotes	coil
T12507	4406-4416	VBG	denotes	containing
T12508	4417-4425	NN	denotes	proteins
T12509	4425-4427	,	denotes	,
T12510	4427-4435	JJ	denotes	distinct
T12511	4436-4440	IN	denotes	from
T12512	4441-4446	JJ	denotes	other
T12514	4447-4453	VBN	denotes	coiled
T12515	4454-4458	NN	denotes	coil
T12513	4459-4467	NNS	denotes	families
T12516	4468-4472	JJ	denotes	such
T12517	4473-4475	IN	denotes	as
T12518	4476-4479	DT	denotes	the
T12519	4480-4488	NNS	denotes	keratins
T12520	4488-4490	,	denotes	,
T12521	4490-4495	NN	denotes	RHAMM
T12522	4496-4499	CC	denotes	and
T12523	4500-4512	NNS	denotes	tropomyosins
T12524	4512-4513	.	denotes	.
T12525	4513-4663	sentence	denotes	Note that the RHAMM proteins form a separate branch more closely related to the tropomyosins and kinesin like proteins (KLP), than the TACC proteins.
T12526	4514-4518	VB	denotes	Note
T12527	4519-4523	IN	denotes	that
T12529	4524-4527	DT	denotes	the
T12531	4528-4533	NN	denotes	RHAMM
T12530	4534-4542	NN	denotes	proteins
T12528	4543-4547	VBP	denotes	form
T12532	4548-4549	DT	denotes	a
T12534	4550-4558	JJ	denotes	separate
T12533	4559-4565	NN	denotes	branch
T12535	4566-4570	RBR	denotes	more
T12536	4571-4578	RB	denotes	closely
T12537	4579-4586	JJ	denotes	related
T12538	4587-4589	IN	denotes	to
T12539	4590-4593	DT	denotes	the
T12540	4594-4606	NNS	denotes	tropomyosins
T12541	4607-4610	CC	denotes	and
T12542	4611-4618	NN	denotes	kinesin
T12543	4619-4623	JJ	denotes	like
T12544	4624-4632	NN	denotes	proteins
T12545	4633-4634	-LRB-	denotes	(
T12546	4634-4637	NN	denotes	KLP
T12547	4637-4638	-RRB-	denotes	)
T12548	4638-4640	,	denotes	,
T12549	4640-4644	IN	denotes	than
T12550	4645-4648	DT	denotes	the
T12552	4649-4653	NN	denotes	TACC
T12551	4654-4662	NN	denotes	proteins
T12553	4662-4663	.	denotes	.
T1812	4664-4665	NN	denotes	A
T1811	4664-4671	sentence	denotes	At the
T1813	4665-4666	IN	denotes	t
T1814	4667-4670	JJ	denotes	the
T1815	4671-4672	sentence	denotes	b
T1816	4671-4672	VBN	denotes	b
T1818	4672-4673	NN	denotes	a
T1817	4672-4686	sentence	denotes	ase of the cho
T1819	4673-4674	VBZ	denotes	s
T1820	4674-4675	JJ	denotes	e
T1821	4676-4678	IN	denotes	of
T1822	4679-4680	VBG	denotes	t
T1823	4680-4682	JJ	denotes	he
T1824	4683-4684	VBN	denotes	c
T1825	4684-4685	JJ	denotes	h
T1826	4685-4686	NNS	denotes	o
T1828	4686-4687	NN	denotes	r
T1827	4686-4692	sentence	denotes	rdate
T1829	4687-4688	JJ	denotes	d
T1830	4688-4689	CC	denotes	a
T1831	4689-4691	NN	denotes	te
T1834	4692-4693	NN	denotes	b
T1832	4692-4890	sentence	denotes	branch of life, a single TACC gene was identified in the genome of the urochordate Ciona intestinalis [11], and a partial TACC sequence from an analysis of the Halocynthia rortezi EST database [12].
T1836	4693-4695	NN	denotes	ra
T1835	4695-4698	NN	denotes	nch
T1837	4699-4701	IN	denotes	of
T1838	4702-4706	NN	denotes	life
T1839	4706-4708	,	denotes	,
T1840	4708-4709	DT	denotes	a
T1842	4710-4716	JJ	denotes	single
T1843	4717-4721	NN	denotes	TACC
T1841	4722-4726	NN	denotes	gene
T1844	4727-4730	VBD	denotes	was
T1833	4731-4741	VBN	denotes	identified
T1845	4742-4744	IN	denotes	in
T1846	4745-4748	DT	denotes	the
T1847	4749-4755	NN	denotes	genome
T1848	4756-4758	IN	denotes	of
T1849	4759-4762	DT	denotes	the
T1850	4763-4774	NN	denotes	urochordate
T1851	4775-4780	NNP	denotes	Ciona
T1852	4781-4793	NNP	denotes	intestinalis
T1853	4794-4795	-LRB-	denotes	[
T1854	4795-4797	CD	denotes	11
T1855	4797-4798	-RRB-	denotes	]
T1856	4798-4800	,	denotes	,
T1857	4800-4803	CC	denotes	and
T1858	4804-4805	DT	denotes	a
T1860	4806-4813	JJ	denotes	partial
T1861	4814-4818	NN	denotes	TACC
T1859	4819-4827	NN	denotes	sequence
T1862	4828-4832	IN	denotes	from
T1863	4833-4835	DT	denotes	an
T1864	4836-4844	NN	denotes	analysis
T1865	4845-4847	IN	denotes	of
T1866	4848-4851	DT	denotes	the
T1868	4852-4863	NNP	denotes	Halocynthia
T1869	4864-4871	NNP	denotes	rortezi
T1870	4872-4875	NN	denotes	EST
T1867	4876-4884	NN	denotes	database
T1871	4885-4886	-LRB-	denotes	[
T1872	4886-4888	CD	denotes	12
T1873	4888-4889	-RRB-	denotes	]
T1874	4889-4890	.	denotes	.
T1875	4890-4990	sentence	denotes	This confirms the original assumption that a single TACC gene was present in the chordate ancestor.
T1876	4891-4895	DT	denotes	This
T1877	4896-4904	VBZ	denotes	confirms
T1878	4905-4908	DT	denotes	the
T1880	4909-4917	JJ	denotes	original
T1879	4918-4928	NN	denotes	assumption
T1881	4929-4933	IN	denotes	that
T1883	4934-4935	DT	denotes	a
T1885	4936-4942	JJ	denotes	single
T1886	4943-4947	NN	denotes	TACC
T1884	4948-4952	NN	denotes	gene
T1882	4953-4956	VBD	denotes	was
T1887	4957-4964	JJ	denotes	present
T1888	4965-4967	IN	denotes	in
T1889	4968-4971	DT	denotes	the
T1891	4972-4980	NN	denotes	chordate
T1890	4981-4989	NN	denotes	ancestor
T1892	4989-4990	.	denotes	.
T1893	4990-5230	sentence	denotes	The next major event in the evolution of the chordate genome has been suggested to have occurred 687 ± 155.7 million years ago (MYA), with the first duplication of the chordate genome, and a second duplication occurring shortly thereafter.
T1894	4991-4994	DT	denotes	The
T1896	4995-4999	JJ	denotes	next
T1897	5000-5005	JJ	denotes	major
T1895	5006-5011	NN	denotes	event
T1899	5012-5014	IN	denotes	in
T1900	5015-5018	DT	denotes	the
T1901	5019-5028	NN	denotes	evolution
T1902	5029-5031	IN	denotes	of
T1903	5032-5035	DT	denotes	the
T1905	5036-5044	NN	denotes	chordate
T1904	5045-5051	NN	denotes	genome
T1906	5052-5055	VBZ	denotes	has
T1907	5056-5060	VBN	denotes	been
T1898	5061-5070	VBN	denotes	suggested
T1908	5071-5073	TO	denotes	to
T1910	5074-5078	VB	denotes	have
T1909	5079-5087	VBN	denotes	occurred
T1911	5088-5091	CD	denotes	687
T1913	5092-5093	SYM	denotes	±
T1912	5094-5099	CD	denotes	155.7
T1915	5100-5107	CD	denotes	million
T1914	5108-5113	NNS	denotes	years
T1916	5114-5117	RB	denotes	ago
T1917	5118-5119	-LRB-	denotes	(
T1918	5119-5122	RB	denotes	MYA
T1919	5122-5123	-RRB-	denotes	)
T1920	5123-5125	,	denotes	,
T1921	5125-5129	IN	denotes	with
T1922	5130-5133	DT	denotes	the
T1924	5134-5139	JJ	denotes	first
T1923	5140-5151	NN	denotes	duplication
T1925	5152-5154	IN	denotes	of
T1926	5155-5158	DT	denotes	the
T1928	5159-5167	NN	denotes	chordate
T1927	5168-5174	NN	denotes	genome
T1929	5174-5176	,	denotes	,
T1930	5176-5179	CC	denotes	and
T1931	5180-5181	DT	denotes	a
T1933	5182-5188	JJ	denotes	second
T1932	5189-5200	NN	denotes	duplication
T1934	5201-5210	VBG	denotes	occurring
T1935	5211-5218	RB	denotes	shortly
T1936	5219-5229	RB	denotes	thereafter
T1937	5229-5230	.	denotes	.
T1938	5230-5669	sentence	denotes	Thus, if the TACC genes were duplicated at both events, we would expect to identify four TACC genes in the most "primitive" compact vertebrate genome sequenced to date, the pufferfish Takifugu rubripes, with three genes corresponding to the human TACC1-3, and, in keeping with the proposed model for genomic duplication of the chromosomal loci for the TACC genes (discussed below), a possible fourth gene deriving from the TACC3 ancestor.
T1939	5231-5235	RB	denotes	Thus
T1941	5235-5237	,	denotes	,
T1942	5237-5239	IN	denotes	if
T1944	5240-5243	DT	denotes	the
T1946	5244-5248	NN	denotes	TACC
T1945	5249-5254	NNS	denotes	genes
T1947	5255-5259	VBD	denotes	were
T1943	5260-5270	VBN	denotes	duplicated
T1948	5271-5273	IN	denotes	at
T1949	5274-5278	DT	denotes	both
T1950	5279-5285	NNS	denotes	events
T1951	5285-5287	,	denotes	,
T1952	5287-5289	PRP	denotes	we
T1953	5290-5295	MD	denotes	would
T1940	5296-5302	VB	denotes	expect
T1954	5303-5305	TO	denotes	to
T1955	5306-5314	VB	denotes	identify
T1956	5315-5319	CD	denotes	four
T1958	5320-5324	NN	denotes	TACC
T1957	5325-5330	NNS	denotes	genes
T1959	5331-5333	IN	denotes	in
T1960	5334-5337	DT	denotes	the
T1962	5338-5342	JJS	denotes	most
T1964	5343-5344	``	denotes	"
T1963	5344-5353	JJ	denotes	primitive
T1965	5353-5354	''	denotes	"
T1966	5355-5362	JJ	denotes	compact
T1967	5363-5373	NN	denotes	vertebrate
T1961	5374-5380	NN	denotes	genome
T1968	5381-5390	VBN	denotes	sequenced
T1969	5391-5393	IN	denotes	to
T1970	5394-5398	NN	denotes	date
T1971	5398-5400	,	denotes	,
T1972	5400-5403	DT	denotes	the
T1973	5404-5414	NN	denotes	pufferfish
T1974	5415-5423	NNP	denotes	Takifugu
T1975	5424-5432	NNP	denotes	rubripes
T1976	5432-5434	,	denotes	,
T1977	5434-5438	IN	denotes	with
T1978	5439-5444	CD	denotes	three
T1979	5445-5450	NNS	denotes	genes
T1980	5451-5464	VBG	denotes	corresponding
T1981	5465-5467	IN	denotes	to
T1982	5468-5471	DT	denotes	the
T1984	5472-5477	JJ	denotes	human
T1983	5478-5483	NN	denotes	TACC1
T1985	5483-5484	HYPH	denotes	-
T1986	5484-5485	CD	denotes	3
T1987	5485-5487	,	denotes	,
T1988	5487-5490	CC	denotes	and
T1989	5490-5492	,	denotes	,
T1990	5492-5494	IN	denotes	in
T1992	5495-5502	VBG	denotes	keeping
T1993	5503-5507	IN	denotes	with
T1994	5508-5511	DT	denotes	the
T1996	5512-5520	VBN	denotes	proposed
T1995	5521-5526	NN	denotes	model
T1997	5527-5530	IN	denotes	for
T1998	5531-5538	JJ	denotes	genomic
T1999	5539-5550	NN	denotes	duplication
T2000	5551-5553	IN	denotes	of
T2001	5554-5557	DT	denotes	the
T2003	5558-5569	JJ	denotes	chromosomal
T2002	5570-5574	NNS	denotes	loci
T2004	5575-5578	IN	denotes	for
T2005	5579-5582	DT	denotes	the
T2007	5583-5587	NN	denotes	TACC
T2006	5588-5593	NNS	denotes	genes
T2008	5594-5595	-LRB-	denotes	(
T2009	5595-5604	VBN	denotes	discussed
T2010	5605-5610	RB	denotes	below
T2011	5610-5611	-RRB-	denotes	)
T2012	5611-5613	,	denotes	,
T2013	5613-5614	DT	denotes	a
T2014	5615-5623	JJ	denotes	possible
T2015	5624-5630	JJ	denotes	fourth
T1991	5631-5635	NN	denotes	gene
T2016	5636-5644	VBG	denotes	deriving
T2017	5645-5649	IN	denotes	from
T2018	5650-5653	DT	denotes	the
T2020	5654-5659	NN	denotes	TACC3
T2019	5660-5668	NN	denotes	ancestor
T2021	5668-5669	.	denotes	.
T2022	5669-5725	sentence	denotes	Indeed, four TACC genes were identified in T. rubripes.
T2023	5670-5676	RB	denotes	Indeed
T2025	5676-5678	,	denotes	,
T2026	5678-5682	CD	denotes	four
T2028	5683-5687	NN	denotes	TACC
T2027	5688-5693	NNS	denotes	genes
T2029	5694-5698	VBD	denotes	were
T2024	5699-5709	VBN	denotes	identified
T2030	5710-5712	IN	denotes	in
T2031	5713-5715	NNP	denotes	T.
T2032	5716-5724	NNP	denotes	rubripes
T2033	5724-5725	.	denotes	.
T2034	5725-5815	sentence	denotes	Of these, two genes corresponded to the T. rubripes orthologues of human TACC2 and TACC3.
T2035	5726-5728	IN	denotes	Of
T2037	5729-5734	DT	denotes	these
T2038	5734-5736	,	denotes	,
T2039	5736-5739	CD	denotes	two
T2040	5740-5745	NNS	denotes	genes
T2036	5746-5758	VBD	denotes	corresponded
T2041	5759-5761	IN	denotes	to
T2042	5762-5765	DT	denotes	the
T2044	5766-5768	NNP	denotes	T.
T2045	5769-5777	NNP	denotes	rubripes
T2043	5778-5789	NNS	denotes	orthologues
T2046	5790-5792	IN	denotes	of
T2047	5793-5798	JJ	denotes	human
T2048	5799-5804	NN	denotes	TACC2
T2049	5805-5808	CC	denotes	and
T2050	5809-5814	NN	denotes	TACC3
T2051	5814-5815	.	denotes	.
T2052	5815-5911	sentence	denotes	However, the other two genes, trTACC1A and trTACC1B are clearly most related to TACC1 (Fig. 1).
T2053	5816-5823	RB	denotes	However
T2055	5823-5825	,	denotes	,
T2056	5825-5828	DT	denotes	the
T2058	5829-5834	JJ	denotes	other
T2059	5835-5838	CD	denotes	two
T2057	5839-5844	NNS	denotes	genes
T2060	5844-5846	,	denotes	,
T2061	5846-5854	NN	denotes	trTACC1A
T2062	5855-5858	CC	denotes	and
T2063	5859-5867	NN	denotes	trTACC1B
T2054	5868-5871	VBP	denotes	are
T2064	5872-5879	RB	denotes	clearly
T2065	5880-5884	RBS	denotes	most
T2066	5885-5892	JJ	denotes	related
T2067	5893-5895	IN	denotes	to
T2068	5896-5901	NN	denotes	TACC1
T2069	5902-5903	-LRB-	denotes	(
T2070	5903-5907	NN	denotes	Fig.
T2071	5908-5909	CD	denotes	1
T2072	5909-5910	-RRB-	denotes	)
T2073	5910-5911	.	denotes	.
T2074	5911-6025	sentence	denotes	Although trTACC1A is highly homologous to trTACC1B, the latter encodes a significantly smaller predicted protein.
T2075	5912-5920	IN	denotes	Although
T2077	5921-5929	NN	denotes	trTACC1A
T2076	5930-5932	VBZ	denotes	is
T2079	5933-5939	RB	denotes	highly
T2080	5940-5950	JJ	denotes	homologous
T2081	5951-5953	IN	denotes	to
T2082	5954-5962	NN	denotes	trTACC1B
T2083	5962-5964	,	denotes	,
T2084	5964-5967	DT	denotes	the
T2085	5968-5974	JJ	denotes	latter
T2078	5975-5982	VBZ	denotes	encodes
T2086	5983-5984	DT	denotes	a
T2088	5985-5998	RB	denotes	significantly
T2089	5999-6006	JJR	denotes	smaller
T2090	6007-6016	VBN	denotes	predicted
T2087	6017-6024	NN	denotes	protein
T2091	6024-6025	.	denotes	.
T2092	6025-6132	sentence	denotes	The trTACC1B gene is encoded by 15 exons over approximately 7 kb of the Takifugu Scaffold 191 (see below).
T2093	6026-6029	DT	denotes	The
T2095	6030-6038	NN	denotes	trTACC1B
T2094	6039-6043	NN	denotes	gene
T2097	6044-6046	VBZ	denotes	is
T2096	6047-6054	VBN	denotes	encoded
T2098	6055-6057	IN	denotes	by
T2099	6058-6060	CD	denotes	15
T2100	6061-6066	NNS	denotes	exons
T2101	6067-6071	IN	denotes	over
T2102	6072-6085	RB	denotes	approximately
T2103	6086-6087	CD	denotes	7
T2104	6088-6090	NN	denotes	kb
T2105	6091-6093	IN	denotes	of
T2106	6094-6097	DT	denotes	the
T2108	6098-6106	NNP	denotes	Takifugu
T2107	6107-6115	NNP	denotes	Scaffold
T2109	6116-6119	CD	denotes	191
T2110	6120-6121	-LRB-	denotes	(
T2111	6121-6124	VB	denotes	see
T2112	6125-6130	RB	denotes	below
T2113	6130-6131	-RRB-	denotes	)
T2114	6131-6132	.	denotes	.
T2115	6132-6273	sentence	denotes	A search of this region using the trTACC1A sequence and gene prediction software has so far failed to identify additional exons of trTACC1B.
T2116	6133-6134	DT	denotes	A
T2117	6135-6141	NN	denotes	search
T2119	6142-6144	IN	denotes	of
T2120	6145-6149	DT	denotes	this
T2121	6150-6156	NN	denotes	region
T2122	6157-6162	VBG	denotes	using
T2123	6163-6166	DT	denotes	the
T2125	6167-6175	NN	denotes	trTACC1A
T2126	6176-6184	NN	denotes	sequence
T2127	6185-6188	CC	denotes	and
T2128	6189-6193	NN	denotes	gene
T2129	6194-6204	NN	denotes	prediction
T2124	6205-6213	NN	denotes	software
T2130	6214-6217	VBZ	denotes	has
T2131	6218-6220	RB	denotes	so
T2132	6221-6224	RB	denotes	far
T2118	6225-6231	VBN	denotes	failed
T2133	6232-6234	TO	denotes	to
T2134	6235-6243	VB	denotes	identify
T2135	6244-6254	JJ	denotes	additional
T2136	6255-6260	NNS	denotes	exons
T2137	6261-6263	IN	denotes	of
T2138	6264-6272	NN	denotes	trTACC1B
T2139	6272-6273	.	denotes	.
T2140	6273-6570	sentence	denotes	However, given the intron/exon structure of this apparently complete gene, it appears likely that trTACC1B is active in the pufferfish, and presumably fulfils either a temporal-spatial specific function within the organism, or a distinct function from the larger trTACC1A product within the cell.
T2141	6274-6281	RB	denotes	However
T2143	6281-6283	,	denotes	,
T2144	6283-6288	VBN	denotes	given
T2145	6289-6292	DT	denotes	the
T2147	6293-6299	NN	denotes	intron
T2149	6299-6300	HYPH	denotes	/
T2148	6300-6304	NN	denotes	exon
T2146	6305-6314	NN	denotes	structure
T2150	6315-6317	IN	denotes	of
T2151	6318-6322	DT	denotes	this
T2153	6323-6333	RB	denotes	apparently
T2154	6334-6342	JJ	denotes	complete
T2152	6343-6347	NN	denotes	gene
T2155	6347-6349	,	denotes	,
T2156	6349-6351	PRP	denotes	it
T2142	6352-6359	VBZ	denotes	appears
T2157	6360-6366	JJ	denotes	likely
T2158	6367-6371	IN	denotes	that
T2160	6372-6380	NN	denotes	trTACC1B
T2159	6381-6383	VBZ	denotes	is
T2161	6384-6390	JJ	denotes	active
T2162	6391-6393	IN	denotes	in
T2163	6394-6397	DT	denotes	the
T2164	6398-6408	NN	denotes	pufferfish
T2165	6408-6410	,	denotes	,
T2166	6410-6413	CC	denotes	and
T2167	6414-6424	RB	denotes	presumably
T2168	6425-6432	VBZ	denotes	fulfils
T2169	6433-6439	CC	denotes	either
T2171	6440-6441	DT	denotes	a
T2172	6442-6450	JJ	denotes	temporal
T2174	6450-6451	HYPH	denotes	-
T2173	6451-6458	JJ	denotes	spatial
T2175	6459-6467	JJ	denotes	specific
T2170	6468-6476	NN	denotes	function
T2176	6477-6483	IN	denotes	within
T2177	6484-6487	DT	denotes	the
T2178	6488-6496	NN	denotes	organism
T2179	6496-6498	,	denotes	,
T2180	6498-6500	CC	denotes	or
T2181	6501-6502	DT	denotes	a
T2183	6503-6511	JJ	denotes	distinct
T2182	6512-6520	NN	denotes	function
T2184	6521-6525	IN	denotes	from
T2185	6526-6529	DT	denotes	the
T2187	6530-6536	JJR	denotes	larger
T2188	6537-6545	NN	denotes	trTACC1A
T2186	6546-6553	NN	denotes	product
T2189	6554-6560	IN	denotes	within
T2190	6561-6564	DT	denotes	the
T2191	6565-6569	NN	denotes	cell
T2192	6569-6570	.	denotes	.
T2193	6570-6862	sentence	denotes	Thus, based upon the surrounding chromosomal loci (see below), the trTACC1A and trTACC1B genes appear to have arisen from the duplication of the chromosomal segment containing the teleost TACC1 ancestor, during the additional partial genomic duplication that occurred in the teleost lineage.
T2194	6571-6575	RB	denotes	Thus
T2196	6575-6577	,	denotes	,
T2197	6577-6582	VBN	denotes	based
T2198	6583-6587	IN	denotes	upon
T2199	6588-6591	DT	denotes	the
T2201	6592-6603	VBG	denotes	surrounding
T2202	6604-6615	JJ	denotes	chromosomal
T2200	6616-6620	NNS	denotes	loci
T2203	6621-6622	-LRB-	denotes	(
T2204	6622-6625	VB	denotes	see
T2205	6626-6631	RB	denotes	below
T2206	6631-6632	-RRB-	denotes	)
T2207	6632-6634	,	denotes	,
T2208	6634-6637	DT	denotes	the
T2210	6638-6646	NN	denotes	trTACC1A
T2211	6647-6650	CC	denotes	and
T2212	6651-6659	NN	denotes	trTACC1B
T2209	6660-6665	NNS	denotes	genes
T2195	6666-6672	VBP	denotes	appear
T2213	6673-6675	TO	denotes	to
T2215	6676-6680	VB	denotes	have
T2214	6681-6687	VBN	denotes	arisen
T2216	6688-6692	IN	denotes	from
T2217	6693-6696	DT	denotes	the
T2218	6697-6708	NN	denotes	duplication
T2219	6709-6711	IN	denotes	of
T2220	6712-6715	DT	denotes	the
T2222	6716-6727	JJ	denotes	chromosomal
T2221	6728-6735	NN	denotes	segment
T2223	6736-6746	VBG	denotes	containing
T2224	6747-6750	DT	denotes	the
T2226	6751-6758	NN	denotes	teleost
T2227	6759-6764	NN	denotes	TACC1
T2225	6765-6773	NN	denotes	ancestor
T2228	6773-6775	,	denotes	,
T2229	6775-6781	IN	denotes	during
T2230	6782-6785	DT	denotes	the
T2232	6786-6796	JJ	denotes	additional
T2233	6797-6804	JJ	denotes	partial
T2234	6805-6812	JJ	denotes	genomic
T2231	6813-6824	NN	denotes	duplication
T2235	6825-6829	WDT	denotes	that
T2236	6830-6838	VBD	denotes	occurred
T2237	6839-6841	IN	denotes	in
T2238	6842-6845	DT	denotes	the
T2240	6846-6853	NN	denotes	teleost
T2239	6854-6861	NN	denotes	lineage
T2241	6861-6862	.	denotes	.
T2242	6862-7049	sentence	denotes	Therefore, this analysis of T. rubripes does not support the hypothesis that the region surrounding the TACC3 ancestor was included in the second round of vertebrate genomic duplication.
T2243	6863-6872	RB	denotes	Therefore
T2245	6872-6874	,	denotes	,
T2246	6874-6878	DT	denotes	this
T2247	6879-6887	NN	denotes	analysis
T2248	6888-6890	IN	denotes	of
T2249	6891-6893	NNP	denotes	T.
T2250	6894-6902	NNP	denotes	rubripes
T2251	6903-6907	VBZ	denotes	does
T2252	6908-6911	RB	denotes	not
T2244	6912-6919	VB	denotes	support
T2253	6920-6923	DT	denotes	the
T2254	6924-6934	NN	denotes	hypothesis
T2255	6935-6939	IN	denotes	that
T2257	6940-6943	DT	denotes	the
T2258	6944-6950	NN	denotes	region
T2259	6951-6962	VBG	denotes	surrounding
T2260	6963-6966	DT	denotes	the
T2262	6967-6972	NN	denotes	TACC3
T2261	6973-6981	NN	denotes	ancestor
T2263	6982-6985	VBD	denotes	was
T2256	6986-6994	VBN	denotes	included
T2264	6995-6997	IN	denotes	in
T2265	6998-7001	DT	denotes	the
T2267	7002-7008	JJ	denotes	second
T2266	7009-7014	NN	denotes	round
T2268	7015-7017	IN	denotes	of
T2269	7018-7028	NN	denotes	vertebrate
T2271	7029-7036	JJ	denotes	genomic
T2270	7037-7048	NN	denotes	duplication
T2272	7048-7049	.	denotes	.
T2273	7049-7257	sentence	denotes	Examination of higher vertebrates led to the identification of splice variants of TACC1 and TACC2 in Mus musculus, and the assembly of the previously unidentified orthologues of TACC1-3 from Rattus norvegus.
T2274	7050-7061	NN	denotes	Examination
T2276	7062-7064	IN	denotes	of
T2277	7065-7071	JJR	denotes	higher
T2278	7072-7083	NNS	denotes	vertebrates
T2275	7084-7087	VBD	denotes	led
T2279	7088-7090	IN	denotes	to
T2280	7091-7094	DT	denotes	the
T2281	7095-7109	NN	denotes	identification
T2282	7110-7112	IN	denotes	of
T2283	7113-7119	NN	denotes	splice
T2284	7120-7128	NNS	denotes	variants
T2285	7129-7131	IN	denotes	of
T2286	7132-7137	NN	denotes	TACC1
T2287	7138-7141	CC	denotes	and
T2288	7142-7147	NN	denotes	TACC2
T2289	7148-7150	IN	denotes	in
T2290	7151-7154	NNP	denotes	Mus
T2291	7155-7163	NNP	denotes	musculus
T2292	7163-7165	,	denotes	,
T2293	7165-7168	CC	denotes	and
T2294	7169-7172	DT	denotes	the
T2295	7173-7181	NN	denotes	assembly
T2296	7182-7184	IN	denotes	of
T2297	7185-7188	DT	denotes	the
T2299	7189-7199	RB	denotes	previously
T2300	7200-7212	JJ	denotes	unidentified
T2298	7213-7224	NNS	denotes	orthologues
T2301	7225-7227	IN	denotes	of
T2302	7228-7233	NN	denotes	TACC1
T2303	7233-7234	HYPH	denotes	-
T2304	7234-7235	CD	denotes	3
T2305	7236-7240	IN	denotes	from
T2306	7241-7247	NN	denotes	Rattus
T2307	7248-7256	NN	denotes	norvegus
T2308	7256-7257	.	denotes	.
T2309	7257-7323	sentence	denotes	In addition, the TACC1X sequence was found on mouse chromosome X.
T2310	7258-7260	IN	denotes	In
T2312	7261-7269	NN	denotes	addition
T2313	7269-7271	,	denotes	,
T2314	7271-7274	DT	denotes	the
T2316	7275-7281	NN	denotes	TACC1X
T2315	7282-7290	NN	denotes	sequence
T2317	7291-7294	VBD	denotes	was
T2311	7295-7300	VBN	denotes	found
T2318	7301-7303	IN	denotes	on
T2319	7304-7309	NN	denotes	mouse
T2321	7310-7320	NN	denotes	chromosome
T2320	7321-7322	NN	denotes	X
T2322	7322-7323	.	denotes	.
T2323	7323-7480	sentence	denotes	This gene is clearly related to the mouse TACC1, however, further examination revealed a mouse B1 repeat distributed over the length of the proposed intron.
T2324	7324-7328	DT	denotes	This
T2325	7329-7333	NN	denotes	gene
T2327	7334-7336	VBZ	denotes	is
T2328	7337-7344	RB	denotes	clearly
T2326	7345-7352	VBN	denotes	related
T2330	7353-7355	IN	denotes	to
T2331	7356-7359	DT	denotes	the
T2333	7360-7365	NN	denotes	mouse
T2332	7366-7371	NN	denotes	TACC1
T2334	7371-7373	,	denotes	,
T2335	7373-7380	RB	denotes	however
T2336	7380-7382	,	denotes	,
T2337	7382-7389	JJ	denotes	further
T2338	7390-7401	NN	denotes	examination
T2329	7402-7410	VBD	denotes	revealed
T2339	7411-7412	DT	denotes	a
T2341	7413-7418	NN	denotes	mouse
T2342	7419-7421	NN	denotes	B1
T2340	7422-7428	NN	denotes	repeat
T2343	7429-7440	VBN	denotes	distributed
T2344	7441-7445	IN	denotes	over
T2345	7446-7449	DT	denotes	the
T2346	7450-7456	NN	denotes	length
T2347	7457-7459	IN	denotes	of
T2348	7460-7463	DT	denotes	the
T2350	7464-7472	VBN	denotes	proposed
T2349	7473-7479	NN	denotes	intron
T2351	7479-7480	.	denotes	.
T2352	7480-7637	sentence	denotes	In addition, no expression of TACC1X was detected in mouse RNA by rt-PCR analysis (data not shown), suggesting that this sequence is a processed pseudogene.
T2353	7481-7483	IN	denotes	In
T2355	7484-7492	NN	denotes	addition
T2356	7492-7494	,	denotes	,
T2357	7494-7496	DT	denotes	no
T2358	7497-7507	NN	denotes	expression
T2359	7508-7510	IN	denotes	of
T2360	7511-7517	NN	denotes	TACC1X
T2361	7518-7521	VBD	denotes	was
T2354	7522-7530	VBN	denotes	detected
T2362	7531-7533	IN	denotes	in
T2363	7534-7539	NN	denotes	mouse
T2364	7540-7543	NN	denotes	RNA
T2365	7544-7546	IN	denotes	by
T2366	7547-7549	NN	denotes	rt
T2368	7549-7550	HYPH	denotes	-
T2367	7550-7553	NN	denotes	PCR
T2369	7554-7562	NN	denotes	analysis
T2370	7563-7564	-LRB-	denotes	(
T2372	7564-7568	NNS	denotes	data
T2373	7569-7572	RB	denotes	not
T2371	7573-7578	VBN	denotes	shown
T2374	7578-7579	-RRB-	denotes	)
T2375	7579-7581	,	denotes	,
T2376	7581-7591	VBG	denotes	suggesting
T2377	7592-7596	IN	denotes	that
T2379	7597-7601	DT	denotes	this
T2380	7602-7610	NN	denotes	sequence
T2378	7611-7613	VBZ	denotes	is
T2381	7614-7615	DT	denotes	a
T2383	7616-7625	VBN	denotes	processed
T2382	7626-7636	NN	denotes	pseudogene
T2384	7636-7637	.	denotes	.
T2385	7637-7846	sentence	denotes	Similarly, TACC1 pseudogenes also exist spread over 22 kb of the centromeric region of human chromosome 10 and, in 8q21, a shorter region 86% identical to the final 359 bp of the TACC1 3' untranslated region.
T2386	7638-7647	RB	denotes	Similarly
T2388	7647-7649	,	denotes	,
T2389	7649-7654	NN	denotes	TACC1
T2390	7655-7666	NNS	denotes	pseudogenes
T2391	7667-7671	RB	denotes	also
T2387	7672-7677	VBP	denotes	exist
T2392	7678-7684	VBN	denotes	spread
T2393	7685-7689	IN	denotes	over
T2394	7690-7692	CD	denotes	22
T2395	7693-7695	NN	denotes	kb
T2396	7696-7698	IN	denotes	of
T2397	7699-7702	DT	denotes	the
T2399	7703-7714	JJ	denotes	centromeric
T2398	7715-7721	NN	denotes	region
T2400	7722-7724	IN	denotes	of
T2401	7725-7730	JJ	denotes	human
T2402	7731-7741	NN	denotes	chromosome
T2403	7742-7744	CD	denotes	10
T2404	7745-7748	CC	denotes	and
T2405	7748-7750	,	denotes	,
T2406	7750-7752	IN	denotes	in
T2407	7753-7757	NN	denotes	8q21
T2408	7757-7759	,	denotes	,
T2409	7759-7760	DT	denotes	a
T2411	7761-7768	JJR	denotes	shorter
T2410	7769-7775	NN	denotes	region
T2412	7776-7778	CD	denotes	86
T2413	7778-7779	NN	denotes	%
T2414	7780-7789	JJ	denotes	identical
T2415	7790-7792	IN	denotes	to
T2416	7793-7796	DT	denotes	the
T2418	7797-7802	JJ	denotes	final
T2419	7803-7806	CD	denotes	359
T2417	7807-7809	NN	denotes	bp
T2420	7810-7812	IN	denotes	of
T2421	7813-7816	DT	denotes	the
T2423	7817-7822	NN	denotes	TACC1
T2424	7823-7824	CD	denotes	3
T2425	7824-7825	SYM	denotes	'
T2426	7826-7838	JJ	denotes	untranslated
T2422	7839-7845	NN	denotes	region
T2427	7845-7846	.	denotes	.
T2428	7846-7935	sentence	denotes	No pseudogenes corresponding to TACC2 or TACC3 were identified in any mammalian species.
T2429	7847-7849	DT	denotes	No
T2430	7850-7861	NNS	denotes	pseudogenes
T2432	7862-7875	VBG	denotes	corresponding
T2433	7876-7878	IN	denotes	to
T2434	7879-7884	NN	denotes	TACC2
T2435	7885-7887	CC	denotes	or
T2436	7888-7893	NN	denotes	TACC3
T2437	7894-7898	VBD	denotes	were
T2431	7899-7909	VBN	denotes	identified
T2438	7910-7912	IN	denotes	in
T2439	7913-7916	DT	denotes	any
T2441	7917-7926	JJ	denotes	mammalian
T2440	7927-7934	NNS	denotes	species
T2442	7934-7935	.	denotes	.
T2677	7937-7953	NN	denotes	Characterization
T2678	7954-7956	IN	denotes	of
T2679	7957-7967	NN	denotes	vertebrate
T2680	7968-7973	NN	denotes	TACC3
T2681	7974-7985	NNS	denotes	orthologues
T2682	7985-8171	sentence	denotes	Based upon current functional analysis, the characterization of TACC3 orthologues is likely to be pivotal to understanding the sequence and functional evolution of the TACC gene family.
T2683	7986-7991	VBN	denotes	Based
T2685	7992-7996	IN	denotes	upon
T2686	7997-8004	JJ	denotes	current
T2688	8005-8015	JJ	denotes	functional
T2687	8016-8024	NN	denotes	analysis
T2689	8024-8026	,	denotes	,
T2690	8026-8029	DT	denotes	the
T2691	8030-8046	NN	denotes	characterization
T2692	8047-8049	IN	denotes	of
T2693	8050-8055	NN	denotes	TACC3
T2694	8056-8067	NNS	denotes	orthologues
T2684	8068-8070	VBZ	denotes	is
T2695	8071-8077	JJ	denotes	likely
T2696	8078-8080	TO	denotes	to
T2697	8081-8083	VB	denotes	be
T2698	8084-8091	JJ	denotes	pivotal
T2699	8092-8094	IN	denotes	to
T2700	8095-8108	VBG	denotes	understanding
T2701	8109-8112	DT	denotes	the
T2702	8113-8121	NN	denotes	sequence
T2703	8122-8125	CC	denotes	and
T2704	8126-8136	JJ	denotes	functional
T2705	8137-8146	NN	denotes	evolution
T2706	8147-8149	IN	denotes	of
T2707	8150-8153	DT	denotes	the
T2709	8154-8158	NN	denotes	TACC
T2710	8159-8163	NN	denotes	gene
T2708	8164-8170	NN	denotes	family
T2711	8170-8171	.	denotes	.
T2712	8171-8300	sentence	denotes	As indicated below, the chromosomal region containing the TACC gene precursors was duplicated twice during vertebrate evolution.
T2713	8172-8174	IN	denotes	As
T2714	8175-8184	VBN	denotes	indicated
T2716	8185-8190	RB	denotes	below
T2717	8190-8192	,	denotes	,
T2718	8192-8195	DT	denotes	the
T2720	8196-8207	JJ	denotes	chromosomal
T2719	8208-8214	NN	denotes	region
T2721	8215-8225	VBG	denotes	containing
T2722	8226-8229	DT	denotes	the
T2724	8230-8234	NN	denotes	TACC
T2725	8235-8239	NN	denotes	gene
T2723	8240-8250	NNS	denotes	precursors
T2726	8251-8254	VBD	denotes	was
T2715	8255-8265	VBN	denotes	duplicated
T2727	8266-8271	RB	denotes	twice
T2728	8272-8278	IN	denotes	during
T2729	8279-8289	NN	denotes	vertebrate
T2730	8290-8299	NN	denotes	evolution
T2731	8299-8300	.	denotes	.
T2732	8300-8572	sentence	denotes	Although the analysis of T. rubripes, rodents and humans so far suggests that the vertebrate TACC3 precursor was not included in the second round of genomic duplication, it could not be excluded that a TACC4 gene may have been lost during the evolution of these lineages.
T2733	8301-8309	IN	denotes	Although
T2735	8310-8313	DT	denotes	the
T2736	8314-8322	NN	denotes	analysis
T2737	8323-8325	IN	denotes	of
T2738	8326-8328	NNP	denotes	T.
T2739	8329-8337	NNP	denotes	rubripes
T2740	8337-8339	,	denotes	,
T2741	8339-8346	NNS	denotes	rodents
T2742	8347-8350	CC	denotes	and
T2743	8351-8357	NNS	denotes	humans
T2744	8358-8360	RB	denotes	so
T2745	8361-8364	RB	denotes	far
T2734	8365-8373	VBZ	denotes	suggests
T2747	8374-8378	IN	denotes	that
T2749	8379-8382	DT	denotes	the
T2751	8383-8393	NN	denotes	vertebrate
T2752	8394-8399	NN	denotes	TACC3
T2750	8400-8409	NN	denotes	precursor
T2753	8410-8413	VBD	denotes	was
T2754	8414-8417	RB	denotes	not
T2748	8418-8426	VBN	denotes	included
T2755	8427-8429	IN	denotes	in
T2756	8430-8433	DT	denotes	the
T2758	8434-8440	JJ	denotes	second
T2757	8441-8446	NN	denotes	round
T2759	8447-8449	IN	denotes	of
T2760	8450-8457	JJ	denotes	genomic
T2761	8458-8469	NN	denotes	duplication
T2762	8469-8471	,	denotes	,
T2763	8471-8473	PRP	denotes	it
T2764	8474-8479	MD	denotes	could
T2765	8480-8483	RB	denotes	not
T2766	8484-8486	VB	denotes	be
T2746	8487-8495	VBN	denotes	excluded
T2767	8496-8500	IN	denotes	that
T2769	8501-8502	DT	denotes	a
T2771	8503-8508	NN	denotes	TACC4
T2770	8509-8513	NN	denotes	gene
T2772	8514-8517	MD	denotes	may
T2773	8518-8522	VB	denotes	have
T2774	8523-8527	VBN	denotes	been
T2768	8528-8532	VBN	denotes	lost
T2775	8533-8539	IN	denotes	during
T2776	8540-8543	DT	denotes	the
T2777	8544-8553	NN	denotes	evolution
T2778	8554-8556	IN	denotes	of
T2779	8557-8562	DT	denotes	these
T2780	8563-8571	NNS	denotes	lineages
T2781	8571-8572	.	denotes	.
T2782	8572-8679	sentence	denotes	The cloning of a new member of the TACC family in Oryctolagus cuniculus has added to this controversy [9].
T2783	8573-8576	DT	denotes	The
T2784	8577-8584	NN	denotes	cloning
T2786	8585-8587	IN	denotes	of
T2787	8588-8589	DT	denotes	a
T2789	8590-8593	JJ	denotes	new
T2788	8594-8600	NN	denotes	member
T2790	8601-8603	IN	denotes	of
T2791	8604-8607	DT	denotes	the
T2793	8608-8612	NN	denotes	TACC
T2792	8613-8619	NN	denotes	family
T2794	8620-8622	IN	denotes	in
T2795	8623-8634	NNP	denotes	Oryctolagus
T2796	8635-8644	NNP	denotes	cuniculus
T2797	8645-8648	VBZ	denotes	has
T2785	8649-8654	VBN	denotes	added
T2798	8655-8657	IN	denotes	to
T2799	8658-8662	DT	denotes	this
T2800	8663-8674	NN	denotes	controversy
T2801	8675-8676	-LRB-	denotes	[
T2802	8676-8677	CD	denotes	9
T2803	8677-8678	-RRB-	denotes	]
T2804	8678-8679	.	denotes	.
T2805	8679-8773	sentence	denotes	Designated TACC4, the 1.5 kb cDNA was highly related, but proposed to be distinct from TACC3.
T2806	8680-8690	VBN	denotes	Designated
T2808	8691-8696	NN	denotes	TACC4
T2809	8696-8698	,	denotes	,
T2810	8698-8701	DT	denotes	the
T2812	8702-8705	CD	denotes	1.5
T2813	8706-8708	NN	denotes	kb
T2811	8709-8713	NN	denotes	cDNA
T2807	8714-8717	VBD	denotes	was
T2814	8718-8724	RB	denotes	highly
T2815	8725-8732	VBN	denotes	related
T2816	8732-8734	,	denotes	,
T2817	8734-8737	CC	denotes	but
T2818	8738-8746	VBN	denotes	proposed
T2819	8747-8749	TO	denotes	to
T2820	8750-8752	VB	denotes	be
T2821	8753-8761	JJ	denotes	distinct
T2822	8762-8766	IN	denotes	from
T2823	8767-8772	NN	denotes	TACC3
T2824	8772-8773	.	denotes	.
T2825	8773-8915	sentence	denotes	However, Northern blot data suggested that this gene produces a single 2.3 kb transcript [9], indicating that the cloned cDNA was incomplete.
T2826	8774-8781	RB	denotes	However
T2828	8781-8783	,	denotes	,
T2829	8783-8791	NNP	denotes	Northern
T2830	8792-8796	NN	denotes	blot
T2831	8797-8801	NNS	denotes	data
T2827	8802-8811	VBD	denotes	suggested
T2832	8812-8816	IN	denotes	that
T2834	8817-8821	DT	denotes	this
T2835	8822-8826	NN	denotes	gene
T2833	8827-8835	VBZ	denotes	produces
T2836	8836-8837	DT	denotes	a
T2838	8838-8844	JJ	denotes	single
T2839	8845-8848	CD	denotes	2.3
T2840	8849-8851	NN	denotes	kb
T2837	8852-8862	NN	denotes	transcript
T2841	8863-8864	-LRB-	denotes	[
T2842	8864-8865	CD	denotes	9
T2843	8865-8866	-RRB-	denotes	]
T2844	8866-8868	,	denotes	,
T2845	8868-8878	VBG	denotes	indicating
T2846	8879-8883	IN	denotes	that
T2848	8884-8887	DT	denotes	the
T2850	8888-8894	VBN	denotes	cloned
T2849	8895-8899	NN	denotes	cDNA
T2847	8900-8903	VBD	denotes	was
T2851	8904-8914	JJ	denotes	incomplete
T2852	8914-8915	.	denotes	.
T2853	8915-9067	sentence	denotes	The degree of similarity to the published sequence of human and mouse TACC3 suggested to us that TACC4 actually represents a partial rabbit TACC3 cDNA.
T2854	8916-8919	DT	denotes	The
T2855	8920-8926	NN	denotes	degree
T2857	8927-8929	IN	denotes	of
T2858	8930-8940	NN	denotes	similarity
T2859	8941-8943	IN	denotes	to
T2860	8944-8947	DT	denotes	the
T2862	8948-8957	VBN	denotes	published
T2861	8958-8966	NN	denotes	sequence
T2863	8967-8969	IN	denotes	of
T2864	8970-8975	JJ	denotes	human
T2866	8976-8979	CC	denotes	and
T2867	8980-8985	NN	denotes	mouse
T2865	8986-8991	NN	denotes	TACC3
T2856	8992-9001	VBD	denotes	suggested
T2868	9002-9004	IN	denotes	to
T2869	9005-9007	PRP	denotes	us
T2870	9008-9012	IN	denotes	that
T2872	9013-9018	NN	denotes	TACC4
T2873	9019-9027	RB	denotes	actually
T2871	9028-9038	VBZ	denotes	represents
T2874	9039-9040	DT	denotes	a
T2876	9041-9048	JJ	denotes	partial
T2877	9049-9055	NN	denotes	rabbit
T2878	9056-9061	NN	denotes	TACC3
T2875	9062-9066	NN	denotes	cDNA
T2879	9066-9067	.	denotes	.
T2880	9067-9204	sentence	denotes	To test this hypothesis, we set out to clone the complete rabbit TACC3 sequence, based upon the known features of human and mouse TACC3.
T2881	9068-9070	TO	denotes	To
T2882	9071-9075	VB	denotes	test
T2884	9076-9080	DT	denotes	this
T2885	9081-9091	NN	denotes	hypothesis
T2886	9091-9093	,	denotes	,
T2887	9093-9095	PRP	denotes	we
T2883	9096-9099	VBD	denotes	set
T2888	9100-9103	RP	denotes	out
T2889	9104-9106	TO	denotes	to
T2890	9107-9112	VB	denotes	clone
T2891	9113-9116	DT	denotes	the
T2893	9117-9125	JJ	denotes	complete
T2894	9126-9132	NN	denotes	rabbit
T2895	9133-9138	NN	denotes	TACC3
T2892	9139-9147	NN	denotes	sequence
T2896	9147-9149	,	denotes	,
T2897	9149-9154	VBN	denotes	based
T2898	9155-9159	IN	denotes	upon
T2899	9160-9163	DT	denotes	the
T2901	9164-9169	JJ	denotes	known
T2900	9170-9178	NNS	denotes	features
T2902	9179-9181	IN	denotes	of
T2903	9182-9187	JJ	denotes	human
T2905	9188-9191	CC	denotes	and
T2906	9192-9197	NN	denotes	mouse
T2904	9198-9203	NN	denotes	TACC3
T2907	9203-9204	.	denotes	.
T2908	9204-9349	sentence	denotes	We have previously noted that the N-terminal and C-terminal regions of the human and mouse TACC3 proteins are highly conserved ([2], see below).
T2909	9205-9207	PRP	denotes	We
T2911	9208-9212	VBP	denotes	have
T2912	9213-9223	RB	denotes	previously
T2910	9224-9229	VBN	denotes	noted
T2913	9230-9234	IN	denotes	that
T2915	9235-9238	DT	denotes	the
T2917	9239-9240	NN	denotes	N
T2919	9240-9241	HYPH	denotes	-
T2918	9241-9249	JJ	denotes	terminal
T2920	9250-9253	CC	denotes	and
T2921	9254-9255	NN	denotes	C
T2923	9255-9256	HYPH	denotes	-
T2922	9256-9264	JJ	denotes	terminal
T2916	9265-9272	NNS	denotes	regions
T2924	9273-9275	IN	denotes	of
T2925	9276-9279	DT	denotes	the
T2927	9280-9285	JJ	denotes	human
T2928	9286-9289	CC	denotes	and
T2929	9290-9295	NN	denotes	mouse
T2930	9296-9301	NN	denotes	TACC3
T2926	9302-9310	NN	denotes	proteins
T2914	9311-9314	VBP	denotes	are
T2931	9315-9321	RB	denotes	highly
T2932	9322-9331	VBN	denotes	conserved
T2933	9332-9333	-LRB-	denotes	(
T2935	9333-9334	-LRB-	denotes	[
T2934	9334-9335	CD	denotes	2
T2936	9335-9336	-RRB-	denotes	]
T2937	9336-9338	,	denotes	,
T2938	9338-9341	VBP	denotes	see
T2939	9342-9347	RB	denotes	below
T2940	9347-9348	-RRB-	denotes	)
T2941	9348-9349	.	denotes	.
T2942	9349-9612	sentence	denotes	Therefore, based upon the sequence identity between these genes, we designed a consensus oligonucleotide primer, T3con2, that would be suitable for the identification of the region containing the initiator methionine of the TACC3 cDNAs from primates and rodents.
T2943	9350-9359	RB	denotes	Therefore
T2945	9359-9361	,	denotes	,
T2946	9361-9366	VBN	denotes	based
T2947	9367-9371	IN	denotes	upon
T2948	9372-9375	DT	denotes	the
T2950	9376-9384	NN	denotes	sequence
T2949	9385-9393	NN	denotes	identity
T2951	9394-9401	IN	denotes	between
T2952	9402-9407	DT	denotes	these
T2953	9408-9413	NNS	denotes	genes
T2954	9413-9415	,	denotes	,
T2955	9415-9417	PRP	denotes	we
T2944	9418-9426	VBD	denotes	designed
T2956	9427-9428	DT	denotes	a
T2958	9429-9438	NN	denotes	consensus
T2959	9439-9454	NN	denotes	oligonucleotide
T2957	9455-9461	NN	denotes	primer
T2960	9461-9463	,	denotes	,
T2961	9463-9469	NN	denotes	T3con2
T2962	9469-9471	,	denotes	,
T2963	9471-9475	WDT	denotes	that
T2965	9476-9481	MD	denotes	would
T2964	9482-9484	VB	denotes	be
T2966	9485-9493	JJ	denotes	suitable
T2967	9494-9497	IN	denotes	for
T2968	9498-9501	DT	denotes	the
T2969	9502-9516	NN	denotes	identification
T2970	9517-9519	IN	denotes	of
T2971	9520-9523	DT	denotes	the
T2972	9524-9530	NN	denotes	region
T2973	9531-9541	VBG	denotes	containing
T2974	9542-9545	DT	denotes	the
T2976	9546-9555	NN	denotes	initiator
T2975	9556-9566	NN	denotes	methionine
T2977	9567-9569	IN	denotes	of
T2978	9570-9573	DT	denotes	the
T2980	9574-9579	NN	denotes	TACC3
T2979	9580-9585	NNS	denotes	cDNAs
T2981	9586-9590	IN	denotes	from
T2982	9591-9599	NNS	denotes	primates
T2983	9600-9603	CC	denotes	and
T2984	9604-9611	NNS	denotes	rodents
T2985	9611-9612	.	denotes	.
T2986	9612-9796	sentence	denotes	Using this primer, in combination with the TACC4-specific RACE primer (RACE2), initially used by Steadman et al [9], we isolated a 1.5 kb PCR product from rabbit brain cDNA by rt-PCR.
T2987	9613-9618	VBG	denotes	Using
T2989	9619-9623	DT	denotes	this
T2990	9624-9630	NN	denotes	primer
T2991	9630-9632	,	denotes	,
T2992	9632-9634	IN	denotes	in
T2993	9635-9646	NN	denotes	combination
T2994	9647-9651	IN	denotes	with
T2995	9652-9655	DT	denotes	the
T2997	9656-9661	NN	denotes	TACC4
T2999	9661-9662	HYPH	denotes	-
T2998	9662-9670	JJ	denotes	specific
T3000	9671-9675	NN	denotes	RACE
T2996	9676-9682	NN	denotes	primer
T3001	9683-9684	-LRB-	denotes	(
T3002	9684-9689	NN	denotes	RACE2
T3003	9689-9690	-RRB-	denotes	)
T3004	9690-9692	,	denotes	,
T3005	9692-9701	RB	denotes	initially
T3006	9702-9706	VBN	denotes	used
T3007	9707-9709	IN	denotes	by
T3008	9710-9718	NNP	denotes	Steadman
T3009	9719-9721	FW	denotes	et
T3010	9722-9724	FW	denotes	al
T3011	9725-9726	-LRB-	denotes	[
T3012	9726-9727	CD	denotes	9
T3013	9727-9728	-RRB-	denotes	]
T3014	9728-9730	,	denotes	,
T3015	9730-9732	PRP	denotes	we
T2988	9733-9741	VBN	denotes	isolated
T3016	9742-9743	DT	denotes	a
T3018	9744-9747	CD	denotes	1.5
T3019	9748-9750	NN	denotes	kb
T3020	9751-9754	NN	denotes	PCR
T3017	9755-9762	NN	denotes	product
T3021	9763-9767	IN	denotes	from
T3022	9768-9774	NN	denotes	rabbit
T3024	9775-9780	NN	denotes	brain
T3023	9781-9785	NN	denotes	cDNA
T3025	9786-9788	IN	denotes	by
T3026	9789-9791	NN	denotes	rt
T3028	9791-9792	HYPH	denotes	-
T3027	9792-9795	NN	denotes	PCR
T3029	9795-9796	.	denotes	.
T3030	9796-9995	sentence	denotes	In combination with 3'RACE, this generated a consensus cDNA of 2283 bp which corresponds to the transcript size of 2.3 kb detected by the "TACC4" sequence reported in Figure 4 of Steadman et al [9].
T3031	9797-9799	IN	denotes	In
T3033	9800-9811	NN	denotes	combination
T3034	9812-9816	IN	denotes	with
T3035	9817-9818	CD	denotes	3
T3037	9818-9819	SYM	denotes	'
T3036	9819-9823	NN	denotes	RACE
T3038	9823-9825	,	denotes	,
T3039	9825-9829	DT	denotes	this
T3032	9830-9839	VBD	denotes	generated
T3040	9840-9841	DT	denotes	a
T3042	9842-9851	NN	denotes	consensus
T3041	9852-9856	NN	denotes	cDNA
T3043	9857-9859	IN	denotes	of
T3044	9860-9864	CD	denotes	2283
T3045	9865-9867	NN	denotes	bp
T3046	9868-9873	WDT	denotes	which
T3047	9874-9885	VBZ	denotes	corresponds
T3048	9886-9888	IN	denotes	to
T3049	9889-9892	DT	denotes	the
T3051	9893-9903	NN	denotes	transcript
T3050	9904-9908	NN	denotes	size
T3052	9909-9911	IN	denotes	of
T3053	9912-9915	CD	denotes	2.3
T3054	9916-9918	NN	denotes	kb
T3055	9919-9927	VBN	denotes	detected
T3056	9928-9930	IN	denotes	by
T3057	9931-9934	DT	denotes	the
T3059	9935-9936	``	denotes	"
T3060	9936-9941	NN	denotes	TACC4
T3061	9941-9942	''	denotes	"
T3058	9943-9951	NN	denotes	sequence
T3062	9952-9960	VBN	denotes	reported
T3063	9961-9963	IN	denotes	in
T3064	9964-9970	NN	denotes	Figure
T3065	9971-9972	CD	denotes	4
T3066	9973-9975	IN	denotes	of
T3067	9976-9984	NNP	denotes	Steadman
T3068	9985-9987	FW	denotes	et
T3069	9988-9990	FW	denotes	al
T3070	9991-9992	-LRB-	denotes	[
T3071	9992-9993	CD	denotes	9
T3072	9993-9994	-RRB-	denotes	]
T3073	9994-9995	.	denotes	.
T3074	9995-10327	sentence	denotes	Thus, while it remains possible that the "TACC4" sequence is an alternative splice product, or is the product of reduplication of the TACC3 gene (events that would be specific to the rabbit), the only transcript detected in rabbit RNA corresponds to the predicted transcript size of the TACC3 sequence that we have identified here.
T3075	9996-10000	RB	denotes	Thus
T3077	10000-10002	,	denotes	,
T3078	10002-10007	IN	denotes	while
T3080	10008-10010	PRP	denotes	it
T3079	10011-10018	VBZ	denotes	remains
T3081	10019-10027	JJ	denotes	possible
T3082	10028-10032	IN	denotes	that
T3084	10033-10036	DT	denotes	the
T3086	10037-10038	``	denotes	"
T3087	10038-10043	NN	denotes	TACC4
T3088	10043-10044	''	denotes	"
T3085	10045-10053	NN	denotes	sequence
T3083	10054-10056	VBZ	denotes	is
T3089	10057-10059	DT	denotes	an
T3091	10060-10071	JJ	denotes	alternative
T3092	10072-10078	NN	denotes	splice
T3090	10079-10086	NN	denotes	product
T3093	10086-10088	,	denotes	,
T3094	10088-10090	CC	denotes	or
T3095	10091-10093	VBZ	denotes	is
T3096	10094-10097	DT	denotes	the
T3097	10098-10105	NN	denotes	product
T3098	10106-10108	IN	denotes	of
T3099	10109-10122	NN	denotes	reduplication
T3100	10123-10125	IN	denotes	of
T3101	10126-10129	DT	denotes	the
T3103	10130-10135	NN	denotes	TACC3
T3102	10136-10140	NN	denotes	gene
T3104	10141-10142	-LRB-	denotes	(
T3105	10142-10148	NNS	denotes	events
T3106	10149-10153	WDT	denotes	that
T3108	10154-10159	MD	denotes	would
T3107	10160-10162	VB	denotes	be
T3109	10163-10171	JJ	denotes	specific
T3110	10172-10174	IN	denotes	to
T3111	10175-10178	DT	denotes	the
T3112	10179-10185	NN	denotes	rabbit
T3113	10185-10186	-RRB-	denotes	)
T3114	10186-10188	,	denotes	,
T3115	10188-10191	DT	denotes	the
T3117	10192-10196	JJ	denotes	only
T3116	10197-10207	NN	denotes	transcript
T3118	10208-10216	VBN	denotes	detected
T3119	10217-10219	IN	denotes	in
T3120	10220-10226	NN	denotes	rabbit
T3121	10227-10230	NN	denotes	RNA
T3076	10231-10242	VBZ	denotes	corresponds
T3122	10243-10245	IN	denotes	to
T3123	10246-10249	DT	denotes	the
T3125	10250-10259	VBN	denotes	predicted
T3126	10260-10270	NN	denotes	transcript
T3124	10271-10275	NN	denotes	size
T3127	10276-10278	IN	denotes	of
T3128	10279-10282	DT	denotes	the
T3130	10283-10288	NN	denotes	TACC3
T3129	10289-10297	NN	denotes	sequence
T3131	10298-10302	WDT	denotes	that
T3133	10303-10305	PRP	denotes	we
T3134	10306-10310	VBP	denotes	have
T3132	10311-10321	VBN	denotes	identified
T3135	10322-10326	RB	denotes	here
T3136	10326-10327	.	denotes	.
T3137	10327-10630	sentence	denotes	Furthermore, the string of nucleotides found at the 5' end of the "TACC4" sequence is also found at the 5' ends of a number of cDNA sequences (e.g. U82468, NM_023500), that were isolated by 5'RACE, suggesting that they may correspond to an artefact of the 5'RACE methodology used in their construction.
T3138	10328-10339	RB	denotes	Furthermore
T3140	10339-10341	,	denotes	,
T3141	10341-10344	DT	denotes	the
T3142	10345-10351	NN	denotes	string
T3143	10352-10354	IN	denotes	of
T3144	10355-10366	NNS	denotes	nucleotides
T3145	10367-10372	VBN	denotes	found
T3146	10373-10375	IN	denotes	at
T3147	10376-10379	DT	denotes	the
T3149	10380-10381	CD	denotes	5
T3150	10381-10382	SYM	denotes	'
T3148	10383-10386	NN	denotes	end
T3151	10387-10389	IN	denotes	of
T3152	10390-10393	DT	denotes	the
T3154	10394-10395	``	denotes	"
T3155	10395-10400	NN	denotes	TACC4
T3156	10400-10401	''	denotes	"
T3153	10402-10410	NN	denotes	sequence
T3157	10411-10413	VBZ	denotes	is
T3158	10414-10418	RB	denotes	also
T3139	10419-10424	VBN	denotes	found
T3159	10425-10427	IN	denotes	at
T3160	10428-10431	DT	denotes	the
T3162	10432-10433	CD	denotes	5
T3163	10433-10434	SYM	denotes	'
T3161	10435-10439	NNS	denotes	ends
T3164	10440-10442	IN	denotes	of
T3165	10443-10444	DT	denotes	a
T3166	10445-10451	NN	denotes	number
T3167	10452-10454	IN	denotes	of
T3168	10455-10459	NN	denotes	cDNA
T3169	10460-10469	NNS	denotes	sequences
T3170	10470-10471	-LRB-	denotes	(
T3171	10471-10475	FW	denotes	e.g.
T3173	10476-10482	NN	denotes	U82468
T3174	10482-10484	,	denotes	,
T3172	10484-10493	NN	denotes	NM_023500
T3175	10493-10494	-RRB-	denotes	)
T3176	10494-10496	,	denotes	,
T3177	10496-10500	WDT	denotes	that
T3179	10501-10505	VBD	denotes	were
T3178	10506-10514	VBN	denotes	isolated
T3180	10515-10517	IN	denotes	by
T3181	10518-10519	CD	denotes	5
T3183	10519-10520	SYM	denotes	'
T3182	10520-10524	NN	denotes	RACE
T3184	10524-10526	,	denotes	,
T3185	10526-10536	VBG	denotes	suggesting
T3186	10537-10541	IN	denotes	that
T3188	10542-10546	PRP	denotes	they
T3189	10547-10550	MD	denotes	may
T3187	10551-10561	VB	denotes	correspond
T3190	10562-10564	IN	denotes	to
T3191	10565-10567	DT	denotes	an
T3192	10568-10576	NN	denotes	artefact
T3193	10577-10579	IN	denotes	of
T3194	10580-10583	DT	denotes	the
T3196	10584-10585	CD	denotes	5
T3197	10585-10586	SYM	denotes	'
T3198	10586-10590	NN	denotes	RACE
T3195	10591-10602	NN	denotes	methodology
T3199	10603-10607	VBN	denotes	used
T3200	10608-10610	IN	denotes	in
T3201	10611-10616	PRP$	denotes	their
T3202	10617-10629	NN	denotes	construction
T3203	10629-10630	.	denotes	.
T3204	10630-10998	sentence	denotes	The rabbit "TACC4" and the rabbit TACC3 sequence that we have isolated are also found on the same branch of the TACC phylogenetic tree with the other TACC3 orthologues, including maskin (Xenopus laevis), and the newly identified TACC3 sequences in Rattus norvegus, Gallus gallus, Silurana tropicalis, Danio rerio and T. rubripes, reported in this manuscript (Fig. 1).
T3205	10631-10634	DT	denotes	The
T3207	10635-10641	NN	denotes	rabbit
T3208	10642-10643	``	denotes	"
T3206	10643-10648	NN	denotes	TACC4
T3210	10648-10649	''	denotes	"
T3211	10650-10653	CC	denotes	and
T3212	10654-10657	DT	denotes	the
T3214	10658-10664	NN	denotes	rabbit
T3213	10665-10670	NN	denotes	TACC3
T3215	10671-10679	NN	denotes	sequence
T3216	10680-10684	WDT	denotes	that
T3218	10685-10687	PRP	denotes	we
T3219	10688-10692	VBP	denotes	have
T3217	10693-10701	VBN	denotes	isolated
T3220	10702-10705	VBP	denotes	are
T3221	10706-10710	RB	denotes	also
T3209	10711-10716	VBN	denotes	found
T3222	10717-10719	IN	denotes	on
T3223	10720-10723	DT	denotes	the
T3225	10724-10728	JJ	denotes	same
T3224	10729-10735	NN	denotes	branch
T3226	10736-10738	IN	denotes	of
T3227	10739-10742	DT	denotes	the
T3229	10743-10747	NN	denotes	TACC
T3230	10748-10760	JJ	denotes	phylogenetic
T3228	10761-10765	NN	denotes	tree
T3231	10766-10770	IN	denotes	with
T3232	10771-10774	DT	denotes	the
T3234	10775-10780	JJ	denotes	other
T3235	10781-10786	NN	denotes	TACC3
T3233	10787-10798	NNS	denotes	orthologues
T3236	10798-10800	,	denotes	,
T3237	10800-10809	VBG	denotes	including
T3238	10810-10816	NN	denotes	maskin
T3239	10817-10818	-LRB-	denotes	(
T3240	10818-10825	NNP	denotes	Xenopus
T3241	10826-10832	NNP	denotes	laevis
T3242	10832-10833	-RRB-	denotes	)
T3243	10833-10835	,	denotes	,
T3244	10835-10838	CC	denotes	and
T3245	10839-10842	DT	denotes	the
T3247	10843-10848	RB	denotes	newly
T3248	10849-10859	VBN	denotes	identified
T3249	10860-10865	NN	denotes	TACC3
T3246	10866-10875	NNS	denotes	sequences
T3250	10876-10878	IN	denotes	in
T3251	10879-10885	NNP	denotes	Rattus
T3252	10886-10894	NNP	denotes	norvegus
T3253	10894-10896	,	denotes	,
T3254	10896-10902	NNP	denotes	Gallus
T3255	10903-10909	NN	denotes	gallus
T3256	10909-10911	,	denotes	,
T3257	10911-10919	NNP	denotes	Silurana
T3258	10920-10930	NNP	denotes	tropicalis
T3259	10930-10932	,	denotes	,
T3260	10932-10937	NNP	denotes	Danio
T3261	10938-10943	NNP	denotes	rerio
T3262	10944-10947	CC	denotes	and
T3263	10948-10950	NNP	denotes	T.
T3264	10951-10959	NNP	denotes	rubripes
T3265	10959-10961	,	denotes	,
T3266	10961-10969	VBN	denotes	reported
T3267	10970-10972	IN	denotes	in
T3268	10973-10977	DT	denotes	this
T3269	10978-10988	NN	denotes	manuscript
T3270	10989-10990	-LRB-	denotes	(
T3271	10990-10994	NN	denotes	Fig.
T3272	10995-10996	CD	denotes	1
T3273	10996-10997	-RRB-	denotes	)
T3274	10997-10998	.	denotes	.
T3275	10998-11107	sentence	denotes	Thus, it is not in a separate branch that may be expected if the sequence was a distinct TACC family member.
T3276	10999-11003	RB	denotes	Thus
T3278	11003-11005	,	denotes	,
T3279	11005-11007	PRP	denotes	it
T3277	11008-11010	VBZ	denotes	is
T3280	11011-11014	RB	denotes	not
T3281	11015-11017	IN	denotes	in
T3282	11018-11019	DT	denotes	a
T3284	11020-11028	JJ	denotes	separate
T3283	11029-11035	NN	denotes	branch
T3285	11036-11040	WDT	denotes	that
T3287	11041-11044	MD	denotes	may
T3288	11045-11047	VB	denotes	be
T3286	11048-11056	VBN	denotes	expected
T3289	11057-11059	IN	denotes	if
T3291	11060-11063	DT	denotes	the
T3292	11064-11072	NN	denotes	sequence
T3290	11073-11076	VBD	denotes	was
T3293	11077-11078	DT	denotes	a
T3295	11079-11087	JJ	denotes	distinct
T3296	11088-11092	NN	denotes	TACC
T3297	11093-11099	NN	denotes	family
T3294	11100-11106	NN	denotes	member
T3298	11106-11107	.	denotes	.
T3412	11109-11118	NN	denotes	Placement
T3413	11119-11121	IN	denotes	of
T3414	11122-11125	DT	denotes	the
T3416	11126-11131	NN	denotes	RHAMM
T3415	11132-11136	NN	denotes	gene
T3417	11137-11139	IN	denotes	in
T3418	11140-11143	DT	denotes	the
T3419	11144-11153	NN	denotes	phylogeny
T3420	11154-11156	IN	denotes	of
T3421	11157-11160	DT	denotes	the
T3423	11161-11167	VBN	denotes	coiled
T3424	11168-11172	NN	denotes	coil
T3425	11173-11177	NN	denotes	gene
T3422	11178-11184	NN	denotes	family
T3426	11184-11276	sentence	denotes	Human RHAMM has also been proposed to be the missing fourth member of the TACC family [10].
T3427	11185-11190	JJ	denotes	Human
T3428	11191-11196	NN	denotes	RHAMM
T3430	11197-11200	VBZ	denotes	has
T3431	11201-11205	RB	denotes	also
T3432	11206-11210	VBN	denotes	been
T3429	11211-11219	VBN	denotes	proposed
T3433	11220-11222	TO	denotes	to
T3434	11223-11225	VB	denotes	be
T3435	11226-11229	DT	denotes	the
T3437	11230-11237	VBG	denotes	missing
T3438	11238-11244	JJ	denotes	fourth
T3436	11245-11251	NN	denotes	member
T3439	11252-11254	IN	denotes	of
T3440	11255-11258	DT	denotes	the
T3442	11259-11263	NN	denotes	TACC
T3441	11264-11270	NN	denotes	family
T3443	11271-11272	-LRB-	denotes	[
T3444	11272-11274	CD	denotes	10
T3445	11274-11275	-RRB-	denotes	]
T3446	11275-11276	.	denotes	.
T3447	11276-11528	sentence	denotes	Evidence used in support of this claim included its chromosomal location on 5q32 in humans (discussed below), its sequence similarity in its coiled coil domain to the TACC domain and the subcellular localization of the RHAMM protein in the centrosome.
T3448	11277-11285	NN	denotes	Evidence
T3450	11286-11290	VBN	denotes	used
T3451	11291-11293	IN	denotes	in
T3452	11294-11301	NN	denotes	support
T3453	11302-11304	IN	denotes	of
T3454	11305-11309	DT	denotes	this
T3455	11310-11315	NN	denotes	claim
T3449	11316-11324	VBD	denotes	included
T3456	11325-11328	PRP$	denotes	its
T3458	11329-11340	JJ	denotes	chromosomal
T3457	11341-11349	NN	denotes	location
T3459	11350-11352	IN	denotes	on
T3460	11353-11357	NN	denotes	5q32
T3461	11358-11360	IN	denotes	in
T3462	11361-11367	NNS	denotes	humans
T3463	11368-11369	-LRB-	denotes	(
T3464	11369-11378	VBN	denotes	discussed
T3465	11379-11384	RB	denotes	below
T3466	11384-11385	-RRB-	denotes	)
T3467	11385-11387	,	denotes	,
T3468	11387-11390	PRP$	denotes	its
T3470	11391-11399	NN	denotes	sequence
T3469	11400-11410	NN	denotes	similarity
T3471	11411-11413	IN	denotes	in
T3472	11414-11417	PRP$	denotes	its
T3474	11418-11424	VBN	denotes	coiled
T3475	11425-11429	NN	denotes	coil
T3473	11430-11436	NN	denotes	domain
T3476	11437-11439	IN	denotes	to
T3477	11440-11443	DT	denotes	the
T3479	11444-11448	NN	denotes	TACC
T3478	11449-11455	NN	denotes	domain
T3480	11456-11459	CC	denotes	and
T3481	11460-11463	DT	denotes	the
T3483	11464-11475	JJ	denotes	subcellular
T3482	11476-11488	NN	denotes	localization
T3484	11489-11491	IN	denotes	of
T3485	11492-11495	DT	denotes	the
T3487	11496-11501	NN	denotes	RHAMM
T3486	11502-11509	NN	denotes	protein
T3488	11510-11512	IN	denotes	in
T3489	11513-11516	DT	denotes	the
T3490	11517-11527	NN	denotes	centrosome
T3491	11527-11528	.	denotes	.
T3492	11528-11737	sentence	denotes	However, if RHAMM were a bona fide TACC family member, then we would predict its evolution would be similar to those of other TACC family members, and fit with the proposed evolution of the vertebrate genome.
T3493	11529-11536	RB	denotes	However
T3495	11536-11538	,	denotes	,
T3496	11538-11540	IN	denotes	if
T3498	11541-11546	NN	denotes	RHAMM
T3497	11547-11551	VB	denotes	were
T3499	11552-11553	DT	denotes	a
T3501	11554-11558	FW	denotes	bona
T3502	11559-11563	FW	denotes	fide
T3503	11564-11568	NN	denotes	TACC
T3504	11569-11575	NN	denotes	family
T3500	11576-11582	NN	denotes	member
T3505	11582-11584	,	denotes	,
T3506	11584-11588	RB	denotes	then
T3507	11589-11591	PRP	denotes	we
T3508	11592-11597	MD	denotes	would
T3494	11598-11605	VB	denotes	predict
T3509	11606-11609	PRP$	denotes	its
T3510	11610-11619	NN	denotes	evolution
T3512	11620-11625	MD	denotes	would
T3511	11626-11628	VB	denotes	be
T3513	11629-11636	JJ	denotes	similar
T3514	11637-11639	IN	denotes	to
T3515	11640-11645	DT	denotes	those
T3516	11646-11648	IN	denotes	of
T3517	11649-11654	JJ	denotes	other
T3519	11655-11659	NN	denotes	TACC
T3520	11660-11666	NN	denotes	family
T3518	11667-11674	NNS	denotes	members
T3521	11674-11676	,	denotes	,
T3522	11676-11679	CC	denotes	and
T3523	11680-11683	VB	denotes	fit
T3524	11684-11688	IN	denotes	with
T3525	11689-11692	DT	denotes	the
T3527	11693-11701	VBN	denotes	proposed
T3526	11702-11711	NN	denotes	evolution
T3528	11712-11714	IN	denotes	of
T3529	11715-11718	DT	denotes	the
T3531	11719-11729	NN	denotes	vertebrate
T3530	11730-11736	NN	denotes	genome
T3532	11736-11737	.	denotes	.
T3533	11737-11902	sentence	denotes	Thus, we set out to identify RHAMM orthologues and related genes in metazoans, so that a more complete phylogeny of the coiled coil super family could be generated.
T3534	11738-11742	RB	denotes	Thus
T3536	11742-11744	,	denotes	,
T3537	11744-11746	PRP	denotes	we
T3535	11747-11750	VBD	denotes	set
T3538	11751-11754	RP	denotes	out
T3539	11755-11757	TO	denotes	to
T3540	11758-11766	VB	denotes	identify
T3541	11767-11772	NN	denotes	RHAMM
T3542	11773-11784	NNS	denotes	orthologues
T3543	11785-11788	CC	denotes	and
T3544	11789-11796	VBN	denotes	related
T3545	11797-11802	NNS	denotes	genes
T3546	11803-11805	IN	denotes	in
T3547	11806-11815	NNS	denotes	metazoans
T3548	11815-11817	,	denotes	,
T3549	11817-11819	IN	denotes	so
T3551	11820-11824	IN	denotes	that
T3552	11825-11826	DT	denotes	a
T3554	11827-11831	RBR	denotes	more
T3555	11832-11840	JJ	denotes	complete
T3553	11841-11850	NN	denotes	phylogeny
T3556	11851-11853	IN	denotes	of
T3557	11854-11857	DT	denotes	the
T3559	11858-11864	VBN	denotes	coiled
T3560	11865-11869	NN	denotes	coil
T3561	11870-11875	JJ	denotes	super
T3558	11876-11882	NN	denotes	family
T3562	11883-11888	MD	denotes	could
T3563	11889-11891	VB	denotes	be
T3550	11892-11901	VBN	denotes	generated
T3564	11901-11902	.	denotes	.
T3565	11902-12038	sentence	denotes	We identified a single RHAMM gene in all deuterostomes for which cDNA and/or genomic sequence was available, including C. intestinalis.
T3566	11903-11905	PRP	denotes	We
T3567	11906-11916	VBD	denotes	identified
T3568	11917-11918	DT	denotes	a
T3570	11919-11925	JJ	denotes	single
T3571	11926-11931	NN	denotes	RHAMM
T3569	11932-11936	NN	denotes	gene
T3572	11937-11939	IN	denotes	in
T3573	11940-11943	DT	denotes	all
T3574	11944-11957	NNS	denotes	deuterostomes
T3575	11958-11961	IN	denotes	for
T3577	11962-11967	WDT	denotes	which
T3578	11968-11972	NN	denotes	cDNA
T3580	11973-11976	CC	denotes	and
T3581	11976-11977	HYPH	denotes	/
T3582	11977-11979	CC	denotes	or
T3583	11980-11987	JJ	denotes	genomic
T3579	11988-11996	NN	denotes	sequence
T3576	11997-12000	VBD	denotes	was
T3584	12001-12010	JJ	denotes	available
T3585	12010-12012	,	denotes	,
T3586	12012-12021	VBG	denotes	including
T3587	12022-12024	NNP	denotes	C.
T3588	12025-12037	NNP	denotes	intestinalis
T3589	12037-12038	.	denotes	.
T3590	12038-12092	sentence	denotes	No RHAMM gene was identified in insects or nematodes.
T3591	12039-12041	DT	denotes	No
T3593	12042-12047	NN	denotes	RHAMM
T3592	12048-12052	NN	denotes	gene
T3595	12053-12056	VBD	denotes	was
T3594	12057-12067	VBN	denotes	identified
T3596	12068-12070	IN	denotes	in
T3597	12071-12078	NNS	denotes	insects
T3598	12079-12081	CC	denotes	or
T3599	12082-12091	NNS	denotes	nematodes
T3600	12091-12092	.	denotes	.
T3601	12092-12261	sentence	denotes	This indicates that the RHAMM/TACC genes diverged after the protostome/deuterostome split 833–933 MYA, but prior to the echinodermata/urochordate divergence (>750 MYA).
T3602	12093-12097	DT	denotes	This
T3603	12098-12107	VBZ	denotes	indicates
T3604	12108-12112	IN	denotes	that
T3606	12113-12116	DT	denotes	the
T3608	12117-12122	NN	denotes	RHAMM
T3610	12122-12123	HYPH	denotes	/
T3609	12123-12127	NN	denotes	TACC
T3607	12128-12133	NNS	denotes	genes
T3605	12134-12142	VBD	denotes	diverged
T3611	12143-12148	IN	denotes	after
T3613	12149-12152	DT	denotes	the
T3615	12153-12163	NN	denotes	protostome
T3616	12163-12164	HYPH	denotes	/
T3614	12164-12176	NN	denotes	deuterostome
T3612	12177-12182	VBD	denotes	split
T3617	12183-12186	CD	denotes	833
T3619	12186-12187	SYM	denotes	–
T3618	12187-12190	CD	denotes	933
T3620	12191-12194	RB	denotes	MYA
T3621	12194-12196	,	denotes	,
T3622	12196-12199	CC	denotes	but
T3623	12200-12205	RB	denotes	prior
T3624	12206-12208	IN	denotes	to
T3625	12209-12212	DT	denotes	the
T3627	12213-12226	NN	denotes	echinodermata
T3629	12226-12227	HYPH	denotes	/
T3628	12227-12238	NN	denotes	urochordate
T3626	12239-12249	NN	denotes	divergence
T3630	12250-12251	-LRB-	denotes	(
T3632	12251-12252	SYM	denotes	>
T3633	12252-12255	CD	denotes	750
T3631	12256-12259	RB	denotes	MYA
T3634	12259-12260	-RRB-	denotes	)
T3635	12260-12261	.	denotes	.
T3636	12261-12539	sentence	denotes	Significantly, sequence and phylogenetic analysis of coiled coil proteins (Fig. 1) clearly shows that RHAMM does not contain a TACC domain and instead forms a distinct family of proteins in the coiled coil superfamily, and is not a direct descendant of the ancestral TACC gene.
T3637	12262-12275	RB	denotes	Significantly
T3639	12275-12277	,	denotes	,
T3640	12277-12285	NN	denotes	sequence
T3642	12286-12289	CC	denotes	and
T3643	12290-12302	JJ	denotes	phylogenetic
T3641	12303-12311	NN	denotes	analysis
T3644	12312-12314	IN	denotes	of
T3645	12315-12321	VBN	denotes	coiled
T3646	12322-12326	NN	denotes	coil
T3647	12327-12335	NN	denotes	proteins
T3648	12336-12337	-LRB-	denotes	(
T3649	12337-12341	NN	denotes	Fig.
T3650	12342-12343	CD	denotes	1
T3651	12343-12344	-RRB-	denotes	)
T3652	12345-12352	RB	denotes	clearly
T3638	12353-12358	VBZ	denotes	shows
T3653	12359-12363	IN	denotes	that
T3655	12364-12369	NN	denotes	RHAMM
T3656	12370-12374	VBZ	denotes	does
T3657	12375-12378	RB	denotes	not
T3654	12379-12386	VB	denotes	contain
T3658	12387-12388	DT	denotes	a
T3660	12389-12393	NN	denotes	TACC
T3659	12394-12400	NN	denotes	domain
T3661	12401-12404	CC	denotes	and
T3662	12405-12412	RB	denotes	instead
T3663	12413-12418	VBZ	denotes	forms
T3664	12419-12420	DT	denotes	a
T3666	12421-12429	JJ	denotes	distinct
T3665	12430-12436	NN	denotes	family
T3667	12437-12439	IN	denotes	of
T3668	12440-12448	NN	denotes	proteins
T3669	12449-12451	IN	denotes	in
T3670	12452-12455	DT	denotes	the
T3672	12456-12462	VBN	denotes	coiled
T3673	12463-12467	NN	denotes	coil
T3671	12468-12479	NN	denotes	superfamily
T3674	12479-12481	,	denotes	,
T3675	12481-12484	CC	denotes	and
T3676	12485-12487	VBZ	denotes	is
T3677	12488-12491	RB	denotes	not
T3678	12492-12493	DT	denotes	a
T3680	12494-12500	JJ	denotes	direct
T3679	12501-12511	NN	denotes	descendant
T3681	12512-12514	IN	denotes	of
T3682	12515-12518	DT	denotes	the
T3684	12519-12528	JJ	denotes	ancestral
T3685	12529-12533	NN	denotes	TACC
T3683	12534-12538	NN	denotes	gene
T3686	12538-12539	.	denotes	.
T4145	12541-12550	NN	denotes	Evolution
T4146	12551-12553	IN	denotes	of
T4147	12554-12557	DT	denotes	the
T4149	12558-12569	JJ	denotes	chromosomal
T4148	12570-12578	NNS	denotes	segments
T4150	12579-12589	VBG	denotes	containing
T4151	12590-12593	DT	denotes	the
T4153	12594-12598	NN	denotes	TACC
T4152	12599-12604	NNS	denotes	genes
T4154	12604-12700	sentence	denotes	The phylogenetic tree of the FGFR genes closely resembles that of the vertebrate TACC1-3 genes.
T4155	12605-12608	DT	denotes	The
T4157	12609-12621	JJ	denotes	phylogenetic
T4156	12622-12626	NN	denotes	tree
T4159	12627-12629	IN	denotes	of
T4160	12630-12633	DT	denotes	the
T4162	12634-12638	NN	denotes	FGFR
T4161	12639-12644	NNS	denotes	genes
T4163	12645-12652	RB	denotes	closely
T4158	12653-12662	VBZ	denotes	resembles
T4164	12663-12667	DT	denotes	that
T4165	12668-12670	IN	denotes	of
T4166	12671-12674	DT	denotes	the
T4168	12675-12685	NN	denotes	vertebrate
T4169	12686-12691	NN	denotes	TACC1
T4170	12691-12692	HYPH	denotes	-
T4171	12692-12693	CD	denotes	3
T4167	12694-12699	NNS	denotes	genes
T4172	12699-12700	.	denotes	.
T4173	12700-12976	sentence	denotes	Recently, detailed analyses of the chromosomal regions containing the FGFR gene family in humans, mouse and the arthopod D. melanogaster have revealed the conservation of paralogous chromosomal segments between these organisms (Fig. 2, [13], Table 1 [see Additional file 1]).
T4174	12701-12709	RB	denotes	Recently
T4176	12709-12711	,	denotes	,
T4177	12711-12719	JJ	denotes	detailed
T4178	12720-12728	NNS	denotes	analyses
T4179	12729-12731	IN	denotes	of
T4180	12732-12735	DT	denotes	the
T4182	12736-12747	JJ	denotes	chromosomal
T4181	12748-12755	NNS	denotes	regions
T4183	12756-12766	VBG	denotes	containing
T4184	12767-12770	DT	denotes	the
T4186	12771-12775	NN	denotes	FGFR
T4187	12776-12780	NN	denotes	gene
T4185	12781-12787	NN	denotes	family
T4188	12788-12790	IN	denotes	in
T4189	12791-12797	NNS	denotes	humans
T4190	12797-12799	,	denotes	,
T4191	12799-12804	NN	denotes	mouse
T4192	12805-12808	CC	denotes	and
T4193	12809-12812	DT	denotes	the
T4194	12813-12821	NN	denotes	arthopod
T4195	12822-12824	NNP	denotes	D.
T4196	12825-12837	NNP	denotes	melanogaster
T4197	12838-12842	VBP	denotes	have
T4175	12843-12851	VBN	denotes	revealed
T4198	12852-12855	DT	denotes	the
T4199	12856-12868	NN	denotes	conservation
T4200	12869-12871	IN	denotes	of
T4201	12872-12882	JJ	denotes	paralogous
T4203	12883-12894	JJ	denotes	chromosomal
T4202	12895-12903	NNS	denotes	segments
T4204	12904-12911	IN	denotes	between
T4205	12912-12917	DT	denotes	these
T4206	12918-12927	NNS	denotes	organisms
T4207	12928-12929	-LRB-	denotes	(
T4209	12929-12933	NN	denotes	Fig.
T4210	12934-12935	CD	denotes	2
T4211	12935-12937	,	denotes	,
T4212	12937-12938	-LRB-	denotes	[
T4213	12938-12940	CD	denotes	13
T4214	12940-12941	-RRB-	denotes	]
T4215	12941-12943	,	denotes	,
T4208	12943-12948	NN	denotes	Table
T4216	12949-12950	CD	denotes	1
T4217	12951-12952	-LRB-	denotes	[
T4218	12952-12955	VB	denotes	see
T4219	12956-12966	JJ	denotes	Additional
T4220	12967-12971	NN	denotes	file
T4221	12972-12973	CD	denotes	1
T4222	12973-12974	-RRB-	denotes	]
T4223	12974-12975	-RRB-	denotes	)
T4224	12975-12976	.	denotes	.
T4225	12976-13285	sentence	denotes	This has provided further support that an ancient chromosomal segment was duplicated twice during vertebrate evolution, with the first duplication that gave rise to the human chromosome 4p16/5q32-ter and human chromosome 8p/10q23-ter ancestors occurring in the early stages after the invertebrate divergence.
T4226	12977-12981	DT	denotes	This
T4228	12982-12985	VBZ	denotes	has
T4227	12986-12994	VBN	denotes	provided
T4229	12995-13002	JJ	denotes	further
T4230	13003-13010	NN	denotes	support
T4231	13011-13015	IN	denotes	that
T4233	13016-13018	DT	denotes	an
T4235	13019-13026	JJ	denotes	ancient
T4236	13027-13038	JJ	denotes	chromosomal
T4234	13039-13046	NN	denotes	segment
T4237	13047-13050	VBD	denotes	was
T4232	13051-13061	VBN	denotes	duplicated
T4238	13062-13067	RB	denotes	twice
T4239	13068-13074	IN	denotes	during
T4240	13075-13085	NN	denotes	vertebrate
T4241	13086-13095	NN	denotes	evolution
T4242	13095-13097	,	denotes	,
T4243	13097-13101	IN	denotes	with
T4244	13102-13105	DT	denotes	the
T4246	13106-13111	JJ	denotes	first
T4245	13112-13123	NN	denotes	duplication
T4248	13124-13128	WDT	denotes	that
T4249	13129-13133	VBD	denotes	gave
T4250	13134-13138	NN	denotes	rise
T4251	13139-13141	IN	denotes	to
T4252	13142-13145	DT	denotes	the
T4254	13146-13151	JJ	denotes	human
T4255	13152-13162	NN	denotes	chromosome
T4257	13163-13167	NN	denotes	4p16
T4259	13167-13168	HYPH	denotes	/
T4258	13168-13172	NN	denotes	5q32
T4260	13172-13173	HYPH	denotes	-
T4256	13173-13176	NN	denotes	ter
T4261	13177-13180	CC	denotes	and
T4262	13181-13186	JJ	denotes	human
T4263	13187-13197	NN	denotes	chromosome
T4265	13198-13200	NN	denotes	8p
T4267	13200-13201	HYPH	denotes	/
T4266	13201-13206	NN	denotes	10q23
T4268	13206-13207	HYPH	denotes	-
T4264	13207-13210	NN	denotes	ter
T4253	13211-13220	NNS	denotes	ancestors
T4247	13221-13230	VBG	denotes	occurring
T4269	13231-13233	IN	denotes	in
T4270	13234-13237	DT	denotes	the
T4272	13238-13243	JJ	denotes	early
T4271	13244-13250	NNS	denotes	stages
T4273	13251-13256	IN	denotes	after
T4274	13257-13260	DT	denotes	the
T4276	13261-13273	NN	denotes	invertebrate
T4275	13274-13284	NN	denotes	divergence
T4277	13284-13285	.	denotes	.
T4278	13285-13503	sentence	denotes	This suggests that the ancestral FGFR-TACC gene pair most probably arose prior to the initial duplication and subsequent divergence of these paralogous chromosomal segments, estimated to have occurred 687 ± 155.7 MYA.
T4279	13286-13290	DT	denotes	This
T4280	13291-13299	VBZ	denotes	suggests
T4281	13300-13304	IN	denotes	that
T4283	13305-13308	DT	denotes	the
T4285	13309-13318	JJ	denotes	ancestral
T4286	13319-13323	NN	denotes	FGFR
T4288	13323-13324	HYPH	denotes	-
T4287	13324-13328	NN	denotes	TACC
T4289	13329-13333	NN	denotes	gene
T4284	13334-13338	NN	denotes	pair
T4290	13339-13343	RBS	denotes	most
T4291	13344-13352	RB	denotes	probably
T4282	13353-13358	VBD	denotes	arose
T4292	13359-13364	JJ	denotes	prior
T4293	13365-13367	IN	denotes	to
T4294	13368-13371	DT	denotes	the
T4296	13372-13379	JJ	denotes	initial
T4295	13380-13391	NN	denotes	duplication
T4297	13392-13395	CC	denotes	and
T4298	13396-13406	JJ	denotes	subsequent
T4299	13407-13417	NN	denotes	divergence
T4300	13418-13420	IN	denotes	of
T4301	13421-13426	DT	denotes	these
T4303	13427-13437	JJ	denotes	paralogous
T4304	13438-13449	JJ	denotes	chromosomal
T4302	13450-13458	NNS	denotes	segments
T4305	13458-13460	,	denotes	,
T4306	13460-13469	VBN	denotes	estimated
T4307	13470-13472	TO	denotes	to
T4309	13473-13477	VB	denotes	have
T4308	13478-13486	VBN	denotes	occurred
T4310	13487-13490	CD	denotes	687
T4312	13491-13492	SYM	denotes	±
T4311	13493-13498	CD	denotes	155.7
T4313	13499-13502	RB	denotes	MYA
T4314	13502-13503	.	denotes	.
T4315	13503-13627	sentence	denotes	This has raised the suggestion that a fourth TACC gene in vertebrates would reside in the same chromosomal region as FGFR4.
T4316	13504-13508	DT	denotes	This
T4318	13509-13512	VBZ	denotes	has
T4317	13513-13519	VBN	denotes	raised
T4319	13520-13523	DT	denotes	the
T4320	13524-13534	NN	denotes	suggestion
T4321	13535-13539	IN	denotes	that
T4323	13540-13541	DT	denotes	a
T4325	13542-13548	JJ	denotes	fourth
T4326	13549-13553	NN	denotes	TACC
T4324	13554-13558	NN	denotes	gene
T4327	13559-13561	IN	denotes	in
T4328	13562-13573	NNS	denotes	vertebrates
T4329	13574-13579	MD	denotes	would
T4322	13580-13586	VB	denotes	reside
T4330	13587-13589	IN	denotes	in
T4331	13590-13593	DT	denotes	the
T4333	13594-13598	JJ	denotes	same
T4334	13599-13610	JJ	denotes	chromosomal
T4332	13611-13617	NN	denotes	region
T4335	13618-13620	IN	denotes	as
T4336	13621-13626	NN	denotes	FGFR4
T4337	13626-13627	.	denotes	.
T4338	13627-13731	sentence	denotes	Indeed this hypothesis has been used in support for the RHAMM gene as a member of the TACC family [10].
T4339	13628-13634	RB	denotes	Indeed
T4341	13635-13639	DT	denotes	this
T4342	13640-13650	NN	denotes	hypothesis
T4343	13651-13654	VBZ	denotes	has
T4344	13655-13659	VBN	denotes	been
T4340	13660-13664	VBN	denotes	used
T4345	13665-13667	IN	denotes	in
T4346	13668-13675	NN	denotes	support
T4347	13676-13679	IN	denotes	for
T4348	13680-13683	DT	denotes	the
T4350	13684-13689	NN	denotes	RHAMM
T4349	13690-13694	NN	denotes	gene
T4351	13695-13697	IN	denotes	as
T4352	13698-13699	DT	denotes	a
T4353	13700-13706	NN	denotes	member
T4354	13707-13709	IN	denotes	of
T4355	13710-13713	DT	denotes	the
T4357	13714-13718	NN	denotes	TACC
T4356	13719-13725	NN	denotes	family
T4358	13726-13727	-LRB-	denotes	[
T4359	13727-13729	CD	denotes	10
T4360	13729-13730	-RRB-	denotes	]
T4361	13730-13731	.	denotes	.
T4362	13731-13806	sentence	denotes	Human RHAMM maps to chromosome 5q32 in a region bounded by GPX3 and NKX2E.
T4363	13732-13737	JJ	denotes	Human
T4364	13738-13743	NN	denotes	RHAMM
T4365	13744-13748	VBZ	denotes	maps
T4366	13749-13751	IN	denotes	to
T4367	13752-13762	NN	denotes	chromosome
T4368	13763-13767	NN	denotes	5q32
T4369	13768-13770	IN	denotes	in
T4370	13771-13772	DT	denotes	a
T4371	13773-13779	NN	denotes	region
T4372	13780-13787	VBN	denotes	bounded
T4373	13788-13790	IN	denotes	by
T4374	13791-13795	NN	denotes	GPX3
T4375	13796-13799	CC	denotes	and
T4376	13800-13805	NN	denotes	NKX2E
T4377	13805-13806	.	denotes	.
T4378	13806-13901	sentence	denotes	These loci separate two clusters of genes on human chromosome 5 that are paralogous with 4p16.
T4379	13807-13812	DT	denotes	These
T4380	13813-13817	NNS	denotes	loci
T4381	13818-13826	VBP	denotes	separate
T4382	13827-13830	CD	denotes	two
T4383	13831-13839	NNS	denotes	clusters
T4384	13840-13842	IN	denotes	of
T4385	13843-13848	NNS	denotes	genes
T4386	13849-13851	IN	denotes	on
T4387	13852-13857	JJ	denotes	human
T4388	13858-13868	NN	denotes	chromosome
T4389	13869-13870	CD	denotes	5
T4390	13871-13875	WDT	denotes	that
T4391	13876-13879	VBP	denotes	are
T4392	13880-13890	JJ	denotes	paralogous
T4393	13891-13895	IN	denotes	with
T4394	13896-13900	CD	denotes	4p16
T4395	13900-13901	.	denotes	.
T4396	13901-14116	sentence	denotes	Interestingly, these three clusters are located on different chromosomes in mouse and rat (Fig. 2), further suggesting that this cluster of genes was transposed into this region after the primate/rodent divergence.
T4397	13902-13915	RB	denotes	Interestingly
T4399	13915-13917	,	denotes	,
T4400	13917-13922	DT	denotes	these
T4402	13923-13928	CD	denotes	three
T4401	13929-13937	NNS	denotes	clusters
T4403	13938-13941	VBP	denotes	are
T4398	13942-13949	VBN	denotes	located
T4404	13950-13952	IN	denotes	on
T4405	13953-13962	JJ	denotes	different
T4406	13963-13974	NNS	denotes	chromosomes
T4407	13975-13977	IN	denotes	in
T4408	13978-13983	NN	denotes	mouse
T4409	13984-13987	CC	denotes	and
T4410	13988-13991	NN	denotes	rat
T4411	13992-13993	-LRB-	denotes	(
T4412	13993-13997	NN	denotes	Fig.
T4413	13998-13999	CD	denotes	2
T4414	13999-14000	-RRB-	denotes	)
T4415	14000-14002	,	denotes	,
T4416	14002-14009	RB	denotes	further
T4417	14010-14020	VBG	denotes	suggesting
T4418	14021-14025	IN	denotes	that
T4420	14026-14030	DT	denotes	this
T4421	14031-14038	NN	denotes	cluster
T4422	14039-14041	IN	denotes	of
T4423	14042-14047	NNS	denotes	genes
T4424	14048-14051	VBD	denotes	was
T4419	14052-14062	VBN	denotes	transposed
T4425	14063-14067	IN	denotes	into
T4426	14068-14072	DT	denotes	this
T4427	14073-14079	NN	denotes	region
T4428	14080-14085	IN	denotes	after
T4429	14086-14089	DT	denotes	the
T4431	14090-14097	NN	denotes	primate
T4433	14097-14098	HYPH	denotes	/
T4432	14098-14104	NN	denotes	rodent
T4430	14105-14115	NN	denotes	divergence
T4434	14115-14116	.	denotes	.
T4435	14116-14117	sentence	denotes
T12611	14127-14133	JJ	denotes	Linear
T12612	14134-14146	NN	denotes	organization
T12613	14147-14149	IN	denotes	of
T12614	14150-14154	NN	denotes	gene
T12615	14155-14163	NNS	denotes	clusters
T12616	14164-14173	VBG	denotes	centering
T12617	14174-14178	IN	denotes	upon
T12618	14179-14182	DT	denotes	the
T12620	14183-14194	JJ	denotes	chromosomal
T12619	14195-14199	NNS	denotes	loci
T12621	14200-14202	IN	denotes	of
T12622	14203-14206	DT	denotes	the
T12624	14207-14211	NN	denotes	FGFR
T12623	14212-14217	NNS	denotes	genes
T12625	14218-14220	IN	denotes	in
T12626	14221-14227	NNS	denotes	humans
T12627	14227-14228	.	denotes	.
T12628	14228-14515	sentence	denotes	Paralogous genes present in at least two of the four loci are shown, with the exception of the region between GPX3 and NKX2E on chromosome 5, which appears to represent a series of intervening genes inserted after duplication of the 4p16/5q32-35 clusters, and genes mentioned in Fig. 3.
T12629	14229-14239	JJ	denotes	Paralogous
T12630	14240-14245	NNS	denotes	genes
T12632	14246-14253	JJ	denotes	present
T12633	14254-14256	IN	denotes	in
T12634	14257-14259	RB	denotes	at
T12636	14260-14265	RBS	denotes	least
T12635	14266-14269	CD	denotes	two
T12637	14270-14272	IN	denotes	of
T12638	14273-14276	DT	denotes	the
T12640	14277-14281	CD	denotes	four
T12639	14282-14286	NNS	denotes	loci
T12641	14287-14290	VBP	denotes	are
T12631	14291-14296	VBN	denotes	shown
T12642	14296-14298	,	denotes	,
T12643	14298-14302	IN	denotes	with
T12644	14303-14306	DT	denotes	the
T12645	14307-14316	NN	denotes	exception
T12646	14317-14319	IN	denotes	of
T12647	14320-14323	DT	denotes	the
T12648	14324-14330	NN	denotes	region
T12649	14331-14338	IN	denotes	between
T12650	14339-14343	NN	denotes	GPX3
T12651	14344-14347	CC	denotes	and
T12652	14348-14353	NN	denotes	NKX2E
T12653	14354-14356	IN	denotes	on
T12654	14357-14367	NN	denotes	chromosome
T12655	14368-14369	CD	denotes	5
T12656	14369-14371	,	denotes	,
T12657	14371-14376	WDT	denotes	which
T12658	14377-14384	VBZ	denotes	appears
T12659	14385-14387	TO	denotes	to
T12660	14388-14397	VB	denotes	represent
T12661	14398-14399	DT	denotes	a
T12662	14400-14406	NN	denotes	series
T12663	14407-14409	IN	denotes	of
T12664	14410-14421	VBG	denotes	intervening
T12665	14422-14427	NNS	denotes	genes
T12666	14428-14436	VBN	denotes	inserted
T12667	14437-14442	IN	denotes	after
T12668	14443-14454	NN	denotes	duplication
T12669	14455-14457	IN	denotes	of
T12670	14458-14461	DT	denotes	the
T12672	14462-14466	NN	denotes	4p16
T12674	14466-14467	HYPH	denotes	/
T12673	14467-14471	NN	denotes	5q32
T12675	14471-14472	HYPH	denotes	-
T12676	14472-14474	CD	denotes	35
T12671	14475-14483	NNS	denotes	clusters
T12677	14483-14485	,	denotes	,
T12678	14485-14488	CC	denotes	and
T12679	14489-14494	NNS	denotes	genes
T12680	14495-14504	VBN	denotes	mentioned
T12681	14505-14507	IN	denotes	in
T12682	14508-14512	NN	denotes	Fig.
T12683	14513-14514	CD	denotes	3
T12684	14514-14515	.	denotes	.
T12685	14515-14585	sentence	denotes	Corresponding syntenic mouse chromosomal regions (mm*) are indicated.
T12686	14516-14529	VBG	denotes	Corresponding
T12688	14530-14538	JJ	denotes	syntenic
T12689	14539-14544	NN	denotes	mouse
T12690	14545-14556	JJ	denotes	chromosomal
T12687	14557-14564	NNS	denotes	regions
T12692	14565-14566	-LRB-	denotes	(
T12693	14566-14568	NNP	denotes	mm
T12694	14568-14569	SYM	denotes	*
T12695	14569-14570	-RRB-	denotes	)
T12696	14571-14574	VBP	denotes	are
T12691	14575-14584	VBN	denotes	indicated
T12697	14584-14585	.	denotes	.
T12698	14585-14693	sentence	denotes	Takifugu rubripes scaffolds are shown (TR*) that contain more than one homologous gene from these clusters.
T12699	14586-14594	NNP	denotes	Takifugu
T12700	14595-14603	NNP	denotes	rubripes
T12701	14604-14613	NNS	denotes	scaffolds
T12703	14614-14617	VBP	denotes	are
T12702	14618-14623	VBN	denotes	shown
T12704	14624-14625	-LRB-	denotes	(
T12705	14625-14627	NN	denotes	TR
T12706	14627-14628	SYM	denotes	*
T12707	14628-14629	-RRB-	denotes	)
T12708	14630-14634	WDT	denotes	that
T12709	14635-14642	VBP	denotes	contain
T12710	14643-14647	JJR	denotes	more
T12712	14648-14652	IN	denotes	than
T12711	14653-14656	CD	denotes	one
T12714	14657-14667	JJ	denotes	homologous
T12713	14668-14672	NN	denotes	gene
T12715	14673-14677	IN	denotes	from
T12716	14678-14683	DT	denotes	these
T12717	14684-14692	NNS	denotes	clusters
T12718	14692-14693	.	denotes	.
T12719	14693-14786	sentence	denotes	Further details on the location of paralogous genes can be found in [see Additional file 1].
T12720	14694-14701	JJ	denotes	Further
T12721	14702-14709	NNS	denotes	details
T12723	14710-14712	IN	denotes	on
T12724	14713-14716	DT	denotes	the
T12725	14717-14725	NN	denotes	location
T12726	14726-14728	IN	denotes	of
T12727	14729-14739	JJ	denotes	paralogous
T12728	14740-14745	NNS	denotes	genes
T12729	14746-14749	MD	denotes	can
T12730	14750-14752	VB	denotes	be
T12722	14753-14758	VBN	denotes	found
T12731	14759-14761	IN	denotes	in
T12732	14762-14763	-LRB-	denotes	[
T12733	14763-14766	VB	denotes	see
T12734	14767-14777	JJ	denotes	Additional
T12735	14778-14782	NN	denotes	file
T12736	14783-14784	CD	denotes	1
T12737	14784-14785	-RRB-	denotes	]
T12738	14785-14786	.	denotes	.
T4437	14787-14794	IN	denotes	Because
T4436	14787-15104	sentence	denotes	Because the conservation of gene order can also provide clues to the evolution of gene regulation, we next attempted to trace the evolution of these paralogous segments by examining the genome of the tunicate C. intestinalis [11] and the most "primitive" compact vertebrate genome sequenced to date, T. rubripes [14].
T4439	14795-14798	DT	denotes	the
T4440	14799-14811	NN	denotes	conservation
T4441	14812-14814	IN	denotes	of
T4442	14815-14819	NN	denotes	gene
T4443	14820-14825	NN	denotes	order
T4444	14826-14829	MD	denotes	can
T4445	14830-14834	RB	denotes	also
T4438	14835-14842	VB	denotes	provide
T4447	14843-14848	NNS	denotes	clues
T4448	14849-14851	IN	denotes	to
T4449	14852-14855	DT	denotes	the
T4450	14856-14865	NN	denotes	evolution
T4451	14866-14868	IN	denotes	of
T4452	14869-14873	NN	denotes	gene
T4453	14874-14884	NN	denotes	regulation
T4454	14884-14886	,	denotes	,
T4455	14886-14888	PRP	denotes	we
T4456	14889-14893	RB	denotes	next
T4446	14894-14903	VBD	denotes	attempted
T4457	14904-14906	TO	denotes	to
T4458	14907-14912	VB	denotes	trace
T4459	14913-14916	DT	denotes	the
T4460	14917-14926	NN	denotes	evolution
T4461	14927-14929	IN	denotes	of
T4462	14930-14935	DT	denotes	these
T4464	14936-14946	JJ	denotes	paralogous
T4463	14947-14955	NNS	denotes	segments
T4465	14956-14958	IN	denotes	by
T4466	14959-14968	VBG	denotes	examining
T4467	14969-14972	DT	denotes	the
T4468	14973-14979	NN	denotes	genome
T4469	14980-14982	IN	denotes	of
T4470	14983-14986	DT	denotes	the
T4471	14987-14995	NN	denotes	tunicate
T4472	14996-14998	NNP	denotes	C.
T4473	14999-15011	NNP	denotes	intestinalis
T4474	15012-15013	-LRB-	denotes	[
T4475	15013-15015	CD	denotes	11
T4476	15015-15016	-RRB-	denotes	]
T4477	15017-15020	CC	denotes	and
T4478	15021-15024	DT	denotes	the
T4480	15025-15029	JJS	denotes	most
T4482	15030-15031	``	denotes	"
T4481	15031-15040	JJ	denotes	primitive
T4483	15040-15041	''	denotes	"
T4484	15042-15049	JJ	denotes	compact
T4485	15050-15060	NN	denotes	vertebrate
T4479	15061-15067	NN	denotes	genome
T4486	15068-15077	VBN	denotes	sequenced
T4487	15078-15080	IN	denotes	to
T4488	15081-15085	NN	denotes	date
T4489	15085-15087	,	denotes	,
T4490	15087-15089	NNP	denotes	T.
T4491	15090-15098	NNP	denotes	rubripes
T4492	15099-15100	-LRB-	denotes	[
T4493	15100-15102	CD	denotes	14
T4494	15102-15103	-RRB-	denotes	]
T4495	15103-15104	.	denotes	.
T4496	15104-15280	sentence	denotes	Although not fully assembled, examination of the genome of T. rubripes confirmed the presence of chromosomal segments paralogous to those found in higher vertebrates (Fig. 2).
T4497	15105-15113	IN	denotes	Although
T4499	15114-15117	RB	denotes	not
T4500	15118-15123	RB	denotes	fully
T4498	15124-15133	VBN	denotes	assembled
T4502	15133-15135	,	denotes	,
T4503	15135-15146	NN	denotes	examination
T4504	15147-15149	IN	denotes	of
T4505	15150-15153	DT	denotes	the
T4506	15154-15160	NN	denotes	genome
T4507	15161-15163	IN	denotes	of
T4508	15164-15166	NNP	denotes	T.
T4509	15167-15175	NNP	denotes	rubripes
T4501	15176-15185	VBD	denotes	confirmed
T4510	15186-15189	DT	denotes	the
T4511	15190-15198	NN	denotes	presence
T4512	15199-15201	IN	denotes	of
T4513	15202-15213	JJ	denotes	chromosomal
T4514	15214-15222	NNS	denotes	segments
T4515	15223-15233	JJ	denotes	paralogous
T4516	15234-15236	IN	denotes	to
T4517	15237-15242	DT	denotes	those
T4518	15243-15248	VBN	denotes	found
T4519	15249-15251	IN	denotes	in
T4520	15252-15258	JJR	denotes	higher
T4521	15259-15270	NNS	denotes	vertebrates
T4522	15271-15272	-LRB-	denotes	(
T4523	15272-15276	NN	denotes	Fig.
T4524	15277-15278	CD	denotes	2
T4525	15278-15279	-RRB-	denotes	)
T4526	15279-15280	.	denotes	.
T4527	15280-15437	sentence	denotes	For instance, the orthologues of GPRK2L and RGS12 are found on T. rubripes scaffold 290 (emb\|CAAB01000290.1), and within 300 kb of each other in human 4p16.
T4528	15281-15284	IN	denotes	For
T4530	15285-15293	NN	denotes	instance
T4531	15293-15295	,	denotes	,
T4532	15295-15298	DT	denotes	the
T4533	15299-15310	NNS	denotes	orthologues
T4534	15311-15313	IN	denotes	of
T4535	15314-15320	NN	denotes	GPRK2L
T4536	15321-15324	CC	denotes	and
T4537	15325-15330	NN	denotes	RGS12
T4538	15331-15334	VBP	denotes	are
T4529	15335-15340	VBN	denotes	found
T4539	15341-15343	IN	denotes	on
T4540	15344-15346	NNP	denotes	T.
T4541	15347-15355	NNP	denotes	rubripes
T4542	15356-15364	NN	denotes	scaffold
T4543	15365-15368	CD	denotes	290
T4544	15369-15370	-LRB-	denotes	(
T4545	15370-15388	NN	denotes	emb\|CAAB01000290.1
T4546	15388-15389	-RRB-	denotes	)
T4547	15389-15391	,	denotes	,
T4548	15391-15394	CC	denotes	and
T4549	15395-15401	IN	denotes	within
T4550	15402-15405	CD	denotes	300
T4551	15406-15408	NN	denotes	kb
T4552	15409-15411	IN	denotes	of
T4553	15412-15416	DT	denotes	each
T4554	15417-15422	JJ	denotes	other
T4555	15423-15425	IN	denotes	in
T4556	15426-15431	JJ	denotes	human
T4557	15432-15436	CD	denotes	4p16
T4558	15436-15437	.	denotes	.
T4559	15437-15565	sentence	denotes	The T. rubripes orthologues of FGFR3, LETM1 and WHSC1 are located on the same 166 kb genomic scaffold 251 (emb\|CAAB01000166.1).
T4560	15438-15441	DT	denotes	The
T4562	15442-15444	NNP	denotes	T.
T4563	15445-15453	NNP	denotes	rubripes
T4561	15454-15465	NNS	denotes	orthologues
T4565	15466-15468	IN	denotes	of
T4566	15469-15474	NN	denotes	FGFR3
T4567	15474-15476	,	denotes	,
T4568	15476-15481	NN	denotes	LETM1
T4569	15482-15485	CC	denotes	and
T4570	15486-15491	NN	denotes	WHSC1
T4571	15492-15495	VBP	denotes	are
T4564	15496-15503	VBN	denotes	located
T4572	15504-15506	IN	denotes	on
T4573	15507-15510	DT	denotes	the
T4575	15511-15515	JJ	denotes	same
T4576	15516-15519	CD	denotes	166
T4577	15520-15522	NN	denotes	kb
T4578	15523-15530	JJ	denotes	genomic
T4574	15531-15539	NN	denotes	scaffold
T4579	15540-15543	CD	denotes	251
T4580	15544-15545	-LRB-	denotes	(
T4581	15545-15563	NN	denotes	emb\|CAAB01000166.1
T4582	15563-15564	-RRB-	denotes	)
T4583	15564-15565	.	denotes	.
T4584	15565-15677	sentence	denotes	Significantly, the three human orthologues of these genes are also located within 300 kb of each other on 4p16.
T4585	15566-15579	RB	denotes	Significantly
T4587	15579-15581	,	denotes	,
T4588	15581-15584	DT	denotes	the
T4590	15585-15590	CD	denotes	three
T4591	15591-15596	JJ	denotes	human
T4589	15597-15608	NNS	denotes	orthologues
T4592	15609-15611	IN	denotes	of
T4593	15612-15617	DT	denotes	these
T4594	15618-15623	NNS	denotes	genes
T4595	15624-15627	VBP	denotes	are
T4596	15628-15632	RB	denotes	also
T4586	15633-15640	VBN	denotes	located
T4597	15641-15647	IN	denotes	within
T4598	15648-15651	CD	denotes	300
T4599	15652-15654	NN	denotes	kb
T4600	15655-15657	IN	denotes	of
T4601	15658-15662	DT	denotes	each
T4602	15663-15668	JJ	denotes	other
T4603	15669-15671	IN	denotes	on
T4604	15672-15676	NN	denotes	4p16
T4605	15676-15677	.	denotes	.
T4606	15677-15769	sentence	denotes	Furthermore, TACC3 and FGFRL map to the overlapping scaffolds 1184/4669 (emb\|CAAB01004668).
T4607	15678-15689	RB	denotes	Furthermore
T4609	15689-15691	,	denotes	,
T4610	15691-15696	NN	denotes	TACC3
T4611	15697-15700	CC	denotes	and
T4612	15701-15706	NN	denotes	FGFRL
T4608	15707-15710	VBP	denotes	map
T4613	15711-15713	IN	denotes	to
T4614	15714-15717	DT	denotes	the
T4616	15718-15729	VBG	denotes	overlapping
T4615	15730-15739	NNS	denotes	scaffolds
T4617	15740-15744	CD	denotes	1184
T4619	15744-15745	HYPH	denotes	/
T4618	15745-15749	CD	denotes	4669
T4620	15750-15751	-LRB-	denotes	(
T4621	15751-15767	NN	denotes	emb\|CAAB01004668
T4622	15767-15768	-RRB-	denotes	)
T4623	15768-15769	.	denotes	.
T4624	15769-16018	sentence	denotes	Similarly, elements of these gene clusters, extending from HMP19 to GPRK6 in human chromosome 5q34-ter are also found in the pufferfish, with the T. rubripes orthologues of NSD1, FGFR4 and a RAB-like gene mapping on scaffold 407 (emb\|CAAB01000407).
T4625	15770-15779	RB	denotes	Similarly
T4627	15779-15781	,	denotes	,
T4628	15781-15789	NNS	denotes	elements
T4629	15790-15792	IN	denotes	of
T4630	15793-15798	DT	denotes	these
T4632	15799-15803	NN	denotes	gene
T4631	15804-15812	NNS	denotes	clusters
T4633	15812-15814	,	denotes	,
T4634	15814-15823	VBG	denotes	extending
T4635	15824-15828	IN	denotes	from
T4636	15829-15834	NN	denotes	HMP19
T4637	15835-15837	IN	denotes	to
T4638	15838-15843	NN	denotes	GPRK6
T4639	15844-15846	IN	denotes	in
T4640	15847-15852	JJ	denotes	human
T4641	15853-15863	NN	denotes	chromosome
T4643	15864-15868	NN	denotes	5q34
T4644	15868-15869	HYPH	denotes	-
T4642	15869-15872	NN	denotes	ter
T4645	15873-15876	VBP	denotes	are
T4646	15877-15881	RB	denotes	also
T4626	15882-15887	VBN	denotes	found
T4647	15888-15890	IN	denotes	in
T4648	15891-15894	DT	denotes	the
T4649	15895-15905	NN	denotes	pufferfish
T4650	15905-15907	,	denotes	,
T4651	15907-15911	IN	denotes	with
T4652	15912-15915	DT	denotes	the
T4654	15916-15918	NNP	denotes	T.
T4655	15919-15927	NNP	denotes	rubripes
T4653	15928-15939	NNS	denotes	orthologues
T4656	15940-15942	IN	denotes	of
T4657	15943-15947	NN	denotes	NSD1
T4658	15947-15949	,	denotes	,
T4659	15949-15954	NN	denotes	FGFR4
T4660	15955-15958	CC	denotes	and
T4661	15959-15960	DT	denotes	a
T4663	15961-15964	NN	denotes	RAB
T4664	15964-15965	HYPH	denotes	-
T4662	15965-15969	JJ	denotes	like
T4666	15970-15974	NN	denotes	gene
T4665	15975-15982	NN	denotes	mapping
T4667	15983-15985	IN	denotes	on
T4668	15986-15994	NN	denotes	scaffold
T4669	15995-15998	CD	denotes	407
T4670	15999-16000	-LRB-	denotes	(
T4671	16000-16016	NN	denotes	emb\|CAAB01000407
T4672	16016-16017	-RRB-	denotes	)
T4673	16017-16018	.	denotes	.
T4674	16018-16115	sentence	denotes	However, there is no evidence for a gene corresponding to a TACC4 gene in any of these clusters.
T4675	16019-16026	RB	denotes	However
T4677	16026-16028	,	denotes	,
T4678	16028-16033	EX	denotes	there
T4676	16034-16036	VBZ	denotes	is
T4679	16037-16039	DT	denotes	no
T4680	16040-16048	NN	denotes	evidence
T4681	16049-16052	IN	denotes	for
T4682	16053-16054	DT	denotes	a
T4683	16055-16059	NN	denotes	gene
T4684	16060-16073	VBG	denotes	corresponding
T4685	16074-16076	IN	denotes	to
T4686	16077-16078	DT	denotes	a
T4688	16079-16084	NN	denotes	TACC4
T4687	16085-16089	NN	denotes	gene
T4689	16090-16092	IN	denotes	in
T4690	16093-16096	DT	denotes	any
T4691	16097-16099	IN	denotes	of
T4692	16100-16105	DT	denotes	these
T4693	16106-16114	NNS	denotes	clusters
T4694	16114-16115	.	denotes	.
T4695	16115-16242	sentence	denotes	As noted above, phylogenetic analysis of the TACC sequences indicate that there are two TACC1 related genes in the pufferfish.
T4696	16116-16118	IN	denotes	As
T4697	16119-16124	VBN	denotes	noted
T4699	16125-16130	RB	denotes	above
T4700	16130-16132	,	denotes	,
T4701	16132-16144	JJ	denotes	phylogenetic
T4702	16145-16153	NN	denotes	analysis
T4703	16154-16156	IN	denotes	of
T4704	16157-16160	DT	denotes	the
T4706	16161-16165	NN	denotes	TACC
T4705	16166-16175	NNS	denotes	sequences
T4698	16176-16184	VBP	denotes	indicate
T4707	16185-16189	IN	denotes	that
T4709	16190-16195	EX	denotes	there
T4708	16196-16199	VBP	denotes	are
T4710	16200-16203	CD	denotes	two
T4712	16204-16209	NN	denotes	TACC1
T4713	16210-16217	VBN	denotes	related
T4711	16218-16223	NNS	denotes	genes
T4714	16224-16226	IN	denotes	in
T4715	16227-16230	DT	denotes	the
T4716	16231-16241	NN	denotes	pufferfish
T4717	16241-16242	.	denotes	.
T4718	16242-16401	sentence	denotes	trTACC1B is located on the 180 kb scaffold 191 (emb\|CAAB01000191.1), which also contains the orthologues of several genes located in human chromosome 8p21-11.
T4719	16243-16251	NN	denotes	trTACC1B
T4721	16252-16254	VBZ	denotes	is
T4720	16255-16262	VBN	denotes	located
T4722	16263-16265	IN	denotes	on
T4723	16266-16269	DT	denotes	the
T4725	16270-16273	CD	denotes	180
T4726	16274-16276	NN	denotes	kb
T4724	16277-16285	NN	denotes	scaffold
T4727	16286-16289	CD	denotes	191
T4728	16290-16291	-LRB-	denotes	(
T4729	16291-16309	NN	denotes	emb\|CAAB01000191.1
T4730	16309-16310	-RRB-	denotes	)
T4731	16310-16312	,	denotes	,
T4732	16312-16317	WDT	denotes	which
T4734	16318-16322	RB	denotes	also
T4733	16323-16331	VBZ	denotes	contains
T4735	16332-16335	DT	denotes	the
T4736	16336-16347	NNS	denotes	orthologues
T4737	16348-16350	IN	denotes	of
T4738	16351-16358	JJ	denotes	several
T4739	16359-16364	NNS	denotes	genes
T4740	16365-16372	VBN	denotes	located
T4741	16373-16375	IN	denotes	in
T4742	16376-16381	JJ	denotes	human
T4744	16382-16392	NN	denotes	chromosome
T4743	16393-16397	NN	denotes	8p21
T4745	16397-16398	HYPH	denotes	-
T4746	16398-16400	CD	denotes	11
T4747	16400-16401	.	denotes	.
T4748	16401-16518	sentence	denotes	Thus, this scaffold represents the more "developed" TACC1 chromosomal segment that is evident in higher vertebrates.
T4749	16402-16406	RB	denotes	Thus
T4751	16406-16408	,	denotes	,
T4752	16408-16412	DT	denotes	this
T4753	16413-16421	NN	denotes	scaffold
T4750	16422-16432	VBZ	denotes	represents
T4754	16433-16436	DT	denotes	the
T4756	16437-16441	RBR	denotes	more
T4758	16442-16443	``	denotes	"
T4757	16443-16452	VBN	denotes	developed
T4759	16452-16453	''	denotes	"
T4760	16454-16459	NN	denotes	TACC1
T4761	16460-16471	JJ	denotes	chromosomal
T4755	16472-16479	NN	denotes	segment
T4762	16480-16484	WDT	denotes	that
T4763	16485-16487	VBZ	denotes	is
T4764	16488-16495	JJ	denotes	evident
T4765	16496-16498	IN	denotes	in
T4766	16499-16505	JJR	denotes	higher
T4767	16506-16517	NNS	denotes	vertebrates
T4768	16517-16518	.	denotes	.
T4769	16518-16612	sentence	denotes	On the other hand, the trTACC1A gene is located in the 396 kb scaffold 12 (emb\|CAAB010012.1).
T4770	16519-16521	IN	denotes	On
T4772	16522-16525	DT	denotes	the
T4774	16526-16531	JJ	denotes	other
T4773	16532-16536	NN	denotes	hand
T4775	16536-16538	,	denotes	,
T4776	16538-16541	DT	denotes	the
T4778	16542-16550	NN	denotes	trTACC1A
T4777	16551-16555	NN	denotes	gene
T4779	16556-16558	VBZ	denotes	is
T4771	16559-16566	VBN	denotes	located
T4780	16567-16569	IN	denotes	in
T4781	16570-16573	DT	denotes	the
T4783	16574-16577	CD	denotes	396
T4784	16578-16580	NN	denotes	kb
T4782	16581-16589	NN	denotes	scaffold
T4785	16590-16592	CD	denotes	12
T4786	16593-16594	-LRB-	denotes	(
T4787	16594-16610	NN	denotes	emb\|CAAB010012.1
T4788	16610-16611	-RRB-	denotes	)
T4789	16611-16612	.	denotes	.
T4790	16612-16810	sentence	denotes	This scaffold also contains the T. rubripes orthologues of MSX1, STX18, D4S234E and the predicted gene LOC118711, in addition to sequences with homology to LOXL, EVC, LOC159291, and the LDB family.
T4791	16613-16617	DT	denotes	This
T4792	16618-16626	NN	denotes	scaffold
T4794	16627-16631	RB	denotes	also
T4793	16632-16640	VBZ	denotes	contains
T4795	16641-16644	DT	denotes	the
T4797	16645-16647	NNP	denotes	T.
T4798	16648-16656	NNP	denotes	rubripes
T4796	16657-16668	NNS	denotes	orthologues
T4799	16669-16671	IN	denotes	of
T4800	16672-16676	NN	denotes	MSX1
T4801	16676-16678	,	denotes	,
T4802	16678-16683	NN	denotes	STX18
T4803	16683-16685	,	denotes	,
T4804	16685-16692	NN	denotes	D4S234E
T4805	16693-16696	CC	denotes	and
T4806	16697-16700	DT	denotes	the
T4808	16701-16710	VBN	denotes	predicted
T4807	16711-16715	NN	denotes	gene
T4809	16716-16725	NN	denotes	LOC118711
T4810	16725-16727	,	denotes	,
T4811	16727-16729	IN	denotes	in
T4812	16730-16738	NN	denotes	addition
T4813	16739-16741	IN	denotes	to
T4814	16742-16751	NNS	denotes	sequences
T4815	16752-16756	IN	denotes	with
T4816	16757-16765	NN	denotes	homology
T4817	16766-16768	IN	denotes	to
T4818	16769-16773	NN	denotes	LOXL
T4819	16773-16775	,	denotes	,
T4820	16775-16778	NN	denotes	EVC
T4821	16778-16780	,	denotes	,
T4822	16780-16789	NN	denotes	LOC159291
T4823	16789-16791	,	denotes	,
T4824	16791-16794	CC	denotes	and
T4825	16795-16798	DT	denotes	the
T4827	16799-16802	NN	denotes	LDB
T4826	16803-16809	NN	denotes	family
T4828	16809-16810	.	denotes	.
T4829	16810-17108	sentence	denotes	Thus, scaffold 12 contains genes found in the regions of human chromosome 4 and 10 that also contain the loci for TACC3 and TACC2, respectively, and may therefore more closely resemble the genomic organization resulting from the initial duplication of the ancestral paralogous chromosomal segment.
T4830	16811-16815	RB	denotes	Thus
T4832	16815-16817	,	denotes	,
T4833	16817-16825	NN	denotes	scaffold
T4834	16826-16828	CD	denotes	12
T4831	16829-16837	VBZ	denotes	contains
T4835	16838-16843	NNS	denotes	genes
T4836	16844-16849	VBN	denotes	found
T4837	16850-16852	IN	denotes	in
T4838	16853-16856	DT	denotes	the
T4839	16857-16864	NNS	denotes	regions
T4840	16865-16867	IN	denotes	of
T4841	16868-16873	JJ	denotes	human
T4843	16874-16884	NN	denotes	chromosome
T4842	16885-16886	CD	denotes	4
T4844	16887-16890	CC	denotes	and
T4845	16891-16893	CD	denotes	10
T4846	16894-16898	WDT	denotes	that
T4848	16899-16903	RB	denotes	also
T4847	16904-16911	VBP	denotes	contain
T4849	16912-16915	DT	denotes	the
T4850	16916-16920	NNS	denotes	loci
T4851	16921-16924	IN	denotes	for
T4852	16925-16930	NN	denotes	TACC3
T4853	16931-16934	CC	denotes	and
T4854	16935-16940	NN	denotes	TACC2
T4855	16940-16942	,	denotes	,
T4856	16942-16954	RB	denotes	respectively
T4857	16954-16956	,	denotes	,
T4858	16956-16959	CC	denotes	and
T4859	16960-16963	MD	denotes	may
T4861	16964-16973	RB	denotes	therefore
T4862	16974-16978	RBR	denotes	more
T4863	16979-16986	RB	denotes	closely
T4860	16987-16995	VB	denotes	resemble
T4864	16996-16999	DT	denotes	the
T4866	17000-17007	JJ	denotes	genomic
T4865	17008-17020	NN	denotes	organization
T4867	17021-17030	VBG	denotes	resulting
T4868	17031-17035	IN	denotes	from
T4869	17036-17039	DT	denotes	the
T4871	17040-17047	JJ	denotes	initial
T4870	17048-17059	NN	denotes	duplication
T4872	17060-17062	IN	denotes	of
T4873	17063-17066	DT	denotes	the
T4875	17067-17076	JJ	denotes	ancestral
T4876	17077-17087	JJ	denotes	paralogous
T4877	17088-17099	JJ	denotes	chromosomal
T4874	17100-17107	NN	denotes	segment
T4878	17107-17108	.	denotes	.
T4879	17108-17238	sentence	denotes	Conserved paralogous clusters may result from the initial clustering of the genes in a relatively small ancestral genomic contig.
T4880	17109-17118	VBN	denotes	Conserved
T4882	17119-17129	JJ	denotes	paralogous
T4881	17130-17138	NNS	denotes	clusters
T4884	17139-17142	MD	denotes	may
T4883	17143-17149	VB	denotes	result
T4885	17150-17154	IN	denotes	from
T4886	17155-17158	DT	denotes	the
T4888	17159-17166	JJ	denotes	initial
T4887	17167-17177	NN	denotes	clustering
T4889	17178-17180	IN	denotes	of
T4890	17181-17184	DT	denotes	the
T4891	17185-17190	NNS	denotes	genes
T4892	17191-17193	IN	denotes	in
T4893	17194-17195	DT	denotes	a
T4895	17196-17206	RB	denotes	relatively
T4896	17207-17212	JJ	denotes	small
T4897	17213-17222	JJ	denotes	ancestral
T4898	17223-17230	JJ	denotes	genomic
T4894	17231-17237	NN	denotes	contig
T4899	17237-17238	.	denotes	.
T4900	17238-17444	sentence	denotes	Some evidence for the existence of "protoclusters" that could correspond to the paralogous chromosomal segments noted in higher vertebrates is present in the genome of the urochordate C. intestinalis [11].
T4901	17239-17243	DT	denotes	Some
T4902	17244-17252	NN	denotes	evidence
T4904	17253-17256	IN	denotes	for
T4905	17257-17260	DT	denotes	the
T4906	17261-17270	NN	denotes	existence
T4907	17271-17273	IN	denotes	of
T4908	17274-17275	``	denotes	"
T4909	17275-17288	NNS	denotes	protoclusters
T4910	17288-17289	''	denotes	"
T4911	17290-17294	WDT	denotes	that
T4913	17295-17300	MD	denotes	could
T4912	17301-17311	VB	denotes	correspond
T4914	17312-17314	IN	denotes	to
T4915	17315-17318	DT	denotes	the
T4917	17319-17329	JJ	denotes	paralogous
T4918	17330-17341	JJ	denotes	chromosomal
T4916	17342-17350	NNS	denotes	segments
T4919	17351-17356	VBN	denotes	noted
T4920	17357-17359	IN	denotes	in
T4921	17360-17366	JJR	denotes	higher
T4922	17367-17378	NNS	denotes	vertebrates
T4903	17379-17381	VBZ	denotes	is
T4923	17382-17389	JJ	denotes	present
T4924	17390-17392	IN	denotes	in
T4925	17393-17396	DT	denotes	the
T4926	17397-17403	NN	denotes	genome
T4927	17404-17406	IN	denotes	of
T4928	17407-17410	DT	denotes	the
T4929	17411-17422	NN	denotes	urochordate
T4930	17423-17425	NNP	denotes	C.
T4931	17426-17438	NNP	denotes	intestinalis
T4932	17439-17440	-LRB-	denotes	[
T4933	17440-17442	CD	denotes	11
T4934	17442-17443	-RRB-	denotes	]
T4935	17443-17444	.	denotes	.
T4936	17444-17712	sentence	denotes	For instance, the orthologues of FGFR, and WHSC1, carboxypeptidase Z and FLJ25359 cluster within an 85 kb region of the C. intestinalis genome and the human orthologues are still maintained in paralogous segments of 4p16, 8p and 10q (Fig. 3, [see Additional file 1]).
T4937	17445-17448	IN	denotes	For
T4939	17449-17457	NN	denotes	instance
T4940	17457-17459	,	denotes	,
T4941	17459-17462	DT	denotes	the
T4942	17463-17474	NNS	denotes	orthologues
T4943	17475-17477	IN	denotes	of
T4944	17478-17482	NN	denotes	FGFR
T4945	17482-17484	,	denotes	,
T4946	17484-17487	CC	denotes	and
T4947	17488-17493	NN	denotes	WHSC1
T4948	17493-17495	,	denotes	,
T4949	17495-17511	NN	denotes	carboxypeptidase
T4950	17512-17513	NN	denotes	Z
T4951	17514-17517	CC	denotes	and
T4952	17518-17526	NN	denotes	FLJ25359
T4938	17527-17534	VBP	denotes	cluster
T4953	17535-17541	IN	denotes	within
T4954	17542-17544	DT	denotes	an
T4956	17545-17547	CD	denotes	85
T4957	17548-17550	NN	denotes	kb
T4955	17551-17557	NN	denotes	region
T4958	17558-17560	IN	denotes	of
T4959	17561-17564	DT	denotes	the
T4961	17565-17567	NNP	denotes	C.
T4962	17568-17580	NNP	denotes	intestinalis
T4960	17581-17587	NN	denotes	genome
T4963	17588-17591	CC	denotes	and
T4964	17592-17595	DT	denotes	the
T4966	17596-17601	JJ	denotes	human
T4965	17602-17613	NNS	denotes	orthologues
T4968	17614-17617	VBP	denotes	are
T4969	17618-17623	RB	denotes	still
T4967	17624-17634	VBN	denotes	maintained
T4970	17635-17637	IN	denotes	in
T4971	17638-17648	JJ	denotes	paralogous
T4972	17649-17657	NNS	denotes	segments
T4973	17658-17660	IN	denotes	of
T4974	17661-17665	NN	denotes	4p16
T4975	17665-17667	,	denotes	,
T4976	17667-17669	NN	denotes	8p
T4977	17670-17673	CC	denotes	and
T4978	17674-17677	NN	denotes	10q
T4979	17678-17679	-LRB-	denotes	(
T4980	17679-17683	NN	denotes	Fig.
T4981	17684-17685	CD	denotes	3
T4982	17685-17687	,	denotes	,
T4983	17687-17688	-LRB-	denotes	[
T4984	17688-17691	VB	denotes	see
T4985	17692-17702	JJ	denotes	Additional
T4986	17703-17707	NN	denotes	file
T4987	17708-17709	CD	denotes	1
T4988	17709-17710	-RRB-	denotes	]
T4989	17710-17711	-RRB-	denotes	)
T4990	17711-17712	.	denotes	.
T4991	17712-18080	sentence	denotes	However, it should be noted that no clusters of genes from the vertebrate paralogous segments are locate close to the TACC or RHAMM genes of C. intestinalis, indicating that the formation of the much larger paralogous segments encompassing the FGFR-TACC genes formed later in evolutionary time, or conversely have been subject to extensive rearrangement in tunicates.
T4992	17713-17720	RB	denotes	However
T4994	17720-17722	,	denotes	,
T4995	17722-17724	PRP	denotes	it
T4996	17725-17731	MD	denotes	should
T4997	17732-17734	VB	denotes	be
T4993	17735-17740	VBN	denotes	noted
T4998	17741-17745	IN	denotes	that
T5000	17746-17748	DT	denotes	no
T5001	17749-17757	NNS	denotes	clusters
T5002	17758-17760	IN	denotes	of
T5003	17761-17766	NNS	denotes	genes
T5004	17767-17771	IN	denotes	from
T5005	17772-17775	DT	denotes	the
T5007	17776-17786	NN	denotes	vertebrate
T5008	17787-17797	JJ	denotes	paralogous
T5006	17798-17806	NNS	denotes	segments
T5009	17807-17810	VBP	denotes	are
T4999	17811-17817	VBN	denotes	locate
T5010	17818-17823	RB	denotes	close
T5011	17824-17826	IN	denotes	to
T5012	17827-17830	DT	denotes	the
T5014	17831-17835	NN	denotes	TACC
T5015	17836-17838	CC	denotes	or
T5016	17839-17844	NN	denotes	RHAMM
T5013	17845-17850	NNS	denotes	genes
T5017	17851-17853	IN	denotes	of
T5018	17854-17856	NNP	denotes	C.
T5019	17857-17869	NNP	denotes	intestinalis
T5020	17869-17871	,	denotes	,
T5021	17871-17881	VBG	denotes	indicating
T5022	17882-17886	IN	denotes	that
T5024	17887-17890	DT	denotes	the
T5025	17891-17900	NN	denotes	formation
T5026	17901-17903	IN	denotes	of
T5027	17904-17907	DT	denotes	the
T5029	17908-17912	RB	denotes	much
T5030	17913-17919	JJR	denotes	larger
T5031	17920-17930	JJ	denotes	paralogous
T5028	17931-17939	NNS	denotes	segments
T5032	17940-17952	VBG	denotes	encompassing
T5033	17953-17956	DT	denotes	the
T5035	17957-17961	NN	denotes	FGFR
T5037	17961-17962	HYPH	denotes	-
T5036	17962-17966	NN	denotes	TACC
T5034	17967-17972	NNS	denotes	genes
T5023	17973-17979	VBD	denotes	formed
T5038	17980-17985	RB	denotes	later
T5039	17986-17988	IN	denotes	in
T5040	17989-18001	JJ	denotes	evolutionary
T5041	18002-18006	NN	denotes	time
T5042	18006-18008	,	denotes	,
T5043	18008-18010	CC	denotes	or
T5044	18011-18021	RB	denotes	conversely
T5046	18022-18026	VBP	denotes	have
T5045	18027-18031	VBN	denotes	been
T5047	18032-18039	JJ	denotes	subject
T5048	18040-18042	IN	denotes	to
T5049	18043-18052	JJ	denotes	extensive
T5050	18053-18066	NN	denotes	rearrangement
T5051	18067-18069	IN	denotes	in
T5052	18070-18079	NNS	denotes	tunicates
T5053	18079-18080	.	denotes	.
T5054	18080-18437	sentence	denotes	In combination with the examination of the T. rubripes genome, this also provides additional evidence that either the second round of duplication of the chromosomal segment that contained the FGFR3/4 ancestor did not include a TACC gene, or that such a gene was lost very early in vertebrate evolution, prior to the divergence of the Gnanthostome lineages.
T5055	18081-18083	IN	denotes	In
T5057	18084-18095	NN	denotes	combination
T5058	18096-18100	IN	denotes	with
T5059	18101-18104	DT	denotes	the
T5060	18105-18116	NN	denotes	examination
T5061	18117-18119	IN	denotes	of
T5062	18120-18123	DT	denotes	the
T5064	18124-18126	NNP	denotes	T.
T5065	18127-18135	NNP	denotes	rubripes
T5063	18136-18142	NN	denotes	genome
T5066	18142-18144	,	denotes	,
T5067	18144-18148	DT	denotes	this
T5068	18149-18153	RB	denotes	also
T5056	18154-18162	VBZ	denotes	provides
T5069	18163-18173	JJ	denotes	additional
T5070	18174-18182	NN	denotes	evidence
T5071	18183-18187	IN	denotes	that
T5073	18188-18194	CC	denotes	either
T5074	18195-18198	DT	denotes	the
T5076	18199-18205	JJ	denotes	second
T5075	18206-18211	NN	denotes	round
T5077	18212-18214	IN	denotes	of
T5078	18215-18226	NN	denotes	duplication
T5079	18227-18229	IN	denotes	of
T5080	18230-18233	DT	denotes	the
T5082	18234-18245	JJ	denotes	chromosomal
T5081	18246-18253	NN	denotes	segment
T5083	18254-18258	WDT	denotes	that
T5084	18259-18268	VBD	denotes	contained
T5085	18269-18272	DT	denotes	the
T5087	18273-18278	NN	denotes	FGFR3
T5088	18278-18279	HYPH	denotes	/
T5089	18279-18280	CD	denotes	4
T5086	18281-18289	NN	denotes	ancestor
T5090	18290-18293	VBD	denotes	did
T5091	18294-18297	RB	denotes	not
T5072	18298-18305	VB	denotes	include
T5092	18306-18307	DT	denotes	a
T5094	18308-18312	NN	denotes	TACC
T5093	18313-18317	NN	denotes	gene
T5095	18317-18319	,	denotes	,
T5096	18319-18321	CC	denotes	or
T5097	18322-18326	IN	denotes	that
T5099	18327-18331	PDT	denotes	such
T5101	18332-18333	DT	denotes	a
T5100	18334-18338	NN	denotes	gene
T5102	18339-18342	VBD	denotes	was
T5098	18343-18347	VBN	denotes	lost
T5103	18348-18352	RB	denotes	very
T5104	18353-18358	RB	denotes	early
T5105	18359-18361	IN	denotes	in
T5106	18362-18372	NN	denotes	vertebrate
T5107	18373-18382	NN	denotes	evolution
T5108	18382-18384	,	denotes	,
T5109	18384-18389	RB	denotes	prior
T5110	18390-18392	IN	denotes	to
T5111	18393-18396	DT	denotes	the
T5112	18397-18407	NN	denotes	divergence
T5113	18408-18410	IN	denotes	of
T5114	18411-18414	DT	denotes	the
T5116	18415-18427	NNP	denotes	Gnanthostome
T5115	18428-18436	NNS	denotes	lineages
T5117	18436-18437	.	denotes	.
T5118	18437-18718	sentence	denotes	However, the final resolution of the initial evolution of these paralogous segment will await the sequencing of the amphioxus and lamprey genomes, which only have one FGFR gene, and therefore should only contain one copy of the other corresponding genes in this conserved segment.
T5119	18438-18445	RB	denotes	However
T5121	18445-18447	,	denotes	,
T5122	18447-18450	DT	denotes	the
T5124	18451-18456	JJ	denotes	final
T5123	18457-18467	NN	denotes	resolution
T5125	18468-18470	IN	denotes	of
T5126	18471-18474	DT	denotes	the
T5128	18475-18482	JJ	denotes	initial
T5127	18483-18492	NN	denotes	evolution
T5129	18493-18495	IN	denotes	of
T5130	18496-18501	DT	denotes	these
T5132	18502-18512	JJ	denotes	paralogous
T5131	18513-18520	NN	denotes	segment
T5133	18521-18525	MD	denotes	will
T5120	18526-18531	VB	denotes	await
T5134	18532-18535	DT	denotes	the
T5135	18536-18546	NN	denotes	sequencing
T5136	18547-18549	IN	denotes	of
T5137	18550-18553	DT	denotes	the
T5139	18554-18563	NN	denotes	amphioxus
T5140	18564-18567	CC	denotes	and
T5141	18568-18575	NN	denotes	lamprey
T5138	18576-18583	NNS	denotes	genomes
T5142	18583-18585	,	denotes	,
T5143	18585-18590	WDT	denotes	which
T5145	18591-18595	RB	denotes	only
T5144	18596-18600	VBP	denotes	have
T5146	18601-18604	CD	denotes	one
T5148	18605-18609	NN	denotes	FGFR
T5147	18610-18614	NN	denotes	gene
T5149	18614-18616	,	denotes	,
T5150	18616-18619	CC	denotes	and
T5151	18620-18629	RB	denotes	therefore
T5153	18630-18636	MD	denotes	should
T5154	18637-18641	RB	denotes	only
T5152	18642-18649	VB	denotes	contain
T5155	18650-18653	CD	denotes	one
T5156	18654-18658	NN	denotes	copy
T5157	18659-18661	IN	denotes	of
T5158	18662-18665	DT	denotes	the
T5160	18666-18671	JJ	denotes	other
T5161	18672-18685	VBG	denotes	corresponding
T5159	18686-18691	NNS	denotes	genes
T5162	18692-18694	IN	denotes	in
T5163	18695-18699	DT	denotes	this
T5165	18700-18709	VBN	denotes	conserved
T5164	18710-18717	NN	denotes	segment
T5166	18717-18718	.	denotes	.
T12814	18729-18738	NN	denotes	Formation
T12815	18739-18741	IN	denotes	of
T12816	18742-18755	NNS	denotes	protoclusters
T12817	18756-18758	IN	denotes	in
T12818	18759-18767	NNP	denotes	Takifugu
T12819	18768-18776	NNP	denotes	rubripes
T12820	18777-18780	CC	denotes	and
T12821	18781-18786	NNP	denotes	Ciona
T12822	18787-18799	NNP	denotes	intestinalis
T12823	18799-18801	:	denotes	:
T12824	18801-18802	-LRB-	denotes	(
T12826	18801-18902	sentence	denotes	(A): Structure of the genomic scaffolds containing the Takifugu rubripes trTACC1A and trTACC1B genes.
T12825	18802-18803	LS	denotes	A
T12828	18803-18804	-RRB-	denotes	)
T12829	18804-18806	:	denotes	:
T12827	18806-18815	NN	denotes	Structure
T12830	18816-18818	IN	denotes	of
T12831	18819-18822	DT	denotes	the
T12833	18823-18830	JJ	denotes	genomic
T12832	18831-18840	NNS	denotes	scaffolds
T12834	18841-18851	VBG	denotes	containing
T12835	18852-18855	DT	denotes	the
T12837	18856-18864	NNP	denotes	Takifugu
T12838	18865-18873	NNS	denotes	rubripes
T12839	18874-18882	NN	denotes	trTACC1A
T12840	18883-18886	CC	denotes	and
T12841	18887-18895	NN	denotes	trTACC1B
T12836	18896-18901	NNS	denotes	genes
T12842	18901-18902	.	denotes	.
T12843	18902-19061	sentence	denotes	Scaffold 12, the site for the trTACC1A gene contains genes found with either homologues or orthologues on the distal long arm of human chromosome 10 and 4p16.
T12844	18903-18911	NN	denotes	Scaffold
T12846	18912-18914	CD	denotes	12
T12847	18914-18916	,	denotes	,
T12848	18916-18919	DT	denotes	the
T12849	18920-18924	NN	denotes	site
T12850	18925-18928	IN	denotes	for
T12851	18929-18932	DT	denotes	the
T12853	18933-18941	NN	denotes	trTACC1A
T12852	18942-18946	NN	denotes	gene
T12845	18947-18955	VBZ	denotes	contains
T12854	18956-18961	NNS	denotes	genes
T12855	18962-18967	VBN	denotes	found
T12856	18968-18972	IN	denotes	with
T12857	18973-18979	CC	denotes	either
T12858	18980-18990	NNS	denotes	homologues
T12859	18991-18993	CC	denotes	or
T12860	18994-19005	NNS	denotes	orthologues
T12861	19006-19008	IN	denotes	on
T12862	19009-19012	DT	denotes	the
T12864	19013-19019	JJ	denotes	distal
T12865	19020-19024	JJ	denotes	long
T12863	19025-19028	NN	denotes	arm
T12866	19029-19031	IN	denotes	of
T12867	19032-19037	JJ	denotes	human
T12869	19038-19048	NN	denotes	chromosome
T12870	19049-19051	CD	denotes	10
T12871	19052-19055	CC	denotes	and
T12868	19056-19060	NN	denotes	4p16
T12872	19060-19061	.	denotes	.
T12873	19061-19195	sentence	denotes	This scaffold, therefore, has some of the characteristics of the predicted immediate ancestor of the TACC1/TACC2 chromosomal segment.
T12874	19062-19066	DT	denotes	This
T12875	19067-19075	NN	denotes	scaffold
T12877	19075-19077	,	denotes	,
T12878	19077-19086	RB	denotes	therefore
T12879	19086-19088	,	denotes	,
T12876	19088-19091	VBZ	denotes	has
T12880	19092-19096	DT	denotes	some
T12881	19097-19099	IN	denotes	of
T12882	19100-19103	DT	denotes	the
T12883	19104-19119	NNS	denotes	characteristics
T12884	19120-19122	IN	denotes	of
T12885	19123-19126	DT	denotes	the
T12887	19127-19136	VBN	denotes	predicted
T12888	19137-19146	JJ	denotes	immediate
T12886	19147-19155	NN	denotes	ancestor
T12889	19156-19158	IN	denotes	of
T12890	19159-19162	DT	denotes	the
T12892	19163-19168	NN	denotes	TACC1
T12894	19168-19169	HYPH	denotes	/
T12893	19169-19174	NN	denotes	TACC2
T12895	19175-19186	JJ	denotes	chromosomal
T12891	19187-19194	NN	denotes	segment
T12896	19194-19195	.	denotes	.
T12897	19195-19321	sentence	denotes	trTACC1B is found on scaffold 191, which contains orthologues of genes found in the proximal short arm of human chromosome 8.
T12898	19196-19204	NN	denotes	trTACC1B
T12900	19205-19207	VBZ	denotes	is
T12899	19208-19213	VBN	denotes	found
T12901	19214-19216	IN	denotes	on
T12902	19217-19225	NN	denotes	scaffold
T12903	19226-19229	CD	denotes	191
T12904	19229-19231	,	denotes	,
T12905	19231-19236	WDT	denotes	which
T12906	19237-19245	VBZ	denotes	contains
T12907	19246-19257	NNS	denotes	orthologues
T12908	19258-19260	IN	denotes	of
T12909	19261-19266	NNS	denotes	genes
T12910	19267-19272	VBN	denotes	found
T12911	19273-19275	IN	denotes	in
T12912	19276-19279	DT	denotes	the
T12914	19280-19288	JJ	denotes	proximal
T12915	19289-19294	JJ	denotes	short
T12913	19295-19298	NN	denotes	arm
T12916	19299-19301	IN	denotes	of
T12917	19302-19307	JJ	denotes	human
T12918	19308-19318	NN	denotes	chromosome
T12919	19319-19320	CD	denotes	8
T12920	19320-19321	.	denotes	.
T12921	19321-19430	sentence	denotes	(B): Ciona intestinalis clusters containing genes found in paralogous segments on human 8, 4p16, 10q and 5q.
T12922	19322-19323	-LRB-	denotes	(
T12923	19323-19324	LS	denotes	B
T12925	19324-19325	-RRB-	denotes	)
T12926	19325-19327	:	denotes	:
T12927	19327-19332	NNP	denotes	Ciona
T12928	19333-19345	NNP	denotes	intestinalis
T12924	19346-19354	NNS	denotes	clusters
T12929	19355-19365	VBG	denotes	containing
T12930	19366-19371	NNS	denotes	genes
T12931	19372-19377	VBN	denotes	found
T12932	19378-19380	IN	denotes	in
T12933	19381-19391	JJ	denotes	paralogous
T12934	19392-19400	NNS	denotes	segments
T12935	19401-19403	IN	denotes	on
T12936	19404-19409	JJ	denotes	human
T12938	19410-19411	CD	denotes	8
T12939	19411-19413	,	denotes	,
T12937	19413-19417	NN	denotes	4p16
T12940	19417-19419	,	denotes	,
T12941	19419-19422	NN	denotes	10q
T12942	19423-19426	CC	denotes	and
T12943	19427-19429	NN	denotes	5q
T12944	19429-19430	.	denotes	.
T12994	19441-19448	JJ	denotes	Genomic
T12995	19449-19458	NN	denotes	structure
T12996	19459-19461	IN	denotes	of
T12997	19462-19465	DT	denotes	the
T12999	19466-19470	NN	denotes	TACC
T12998	19471-19476	NNS	denotes	genes
T13000	19476-19477	.	denotes	.
T13001	19477-19563	sentence	denotes	Conserved regions known to bind protein factors in all human TACC proteins are shown.
T13002	19478-19487	VBN	denotes	Conserved
T13003	19488-19495	NNS	denotes	regions
T13005	19496-19501	VBN	denotes	known
T13006	19502-19504	TO	denotes	to
T13007	19505-19509	VB	denotes	bind
T13008	19510-19517	NN	denotes	protein
T13009	19518-19525	NNS	denotes	factors
T13010	19526-19528	IN	denotes	in
T13011	19529-19532	DT	denotes	all
T13013	19533-19538	JJ	denotes	human
T13014	19539-19543	NN	denotes	TACC
T13012	19544-19552	NN	denotes	proteins
T13015	19553-19556	VBP	denotes	are
T13004	19557-19562	VBN	denotes	shown
T13016	19562-19563	.	denotes	.
T13017	19563-19647	sentence	denotes	The SDP repeat of human TACC1-3 is known to bind GAS41 ([3,15] and data not shown).
T13018	19564-19567	DT	denotes	The
T13020	19568-19571	NN	denotes	SDP
T13019	19572-19578	NN	denotes	repeat
T13022	19579-19581	IN	denotes	of
T13023	19582-19587	JJ	denotes	human
T13024	19588-19593	NN	denotes	TACC1
T13025	19593-19594	HYPH	denotes	-
T13026	19594-19595	CD	denotes	3
T13027	19596-19598	VBZ	denotes	is
T13021	19599-19604	VBN	denotes	known
T13028	19605-19607	TO	denotes	to
T13029	19608-19612	VB	denotes	bind
T13030	19613-19618	NN	denotes	GAS41
T13031	19619-19620	-LRB-	denotes	(
T13033	19620-19621	-LRB-	denotes	[
T13034	19621-19622	CD	denotes	3
T13035	19622-19623	,	denotes	,
T13032	19623-19625	CD	denotes	15
T13036	19625-19626	-RRB-	denotes	]
T13037	19627-19630	CC	denotes	and
T13038	19631-19635	NNS	denotes	data
T13040	19636-19639	RB	denotes	not
T13039	19640-19645	VBN	denotes	shown
T13041	19645-19646	-RRB-	denotes	)
T13042	19646-19647	.	denotes	.
T13043	19647-19743	sentence	denotes	The TACC domain binds ch-TOG and members of the Aurora kinases in all species examined to date.
T13044	19648-19651	DT	denotes	The
T13046	19652-19656	NN	denotes	TACC
T13045	19657-19663	NN	denotes	domain
T13047	19664-19669	VBZ	denotes	binds
T13048	19670-19672	NN	denotes	ch
T13050	19672-19673	HYPH	denotes	-
T13049	19673-19676	NN	denotes	TOG
T13051	19677-19680	CC	denotes	and
T13052	19681-19688	NNS	denotes	members
T13053	19689-19691	IN	denotes	of
T13054	19692-19695	DT	denotes	the
T13056	19696-19702	NNP	denotes	Aurora
T13055	19703-19710	NNS	denotes	kinases
T13057	19711-19713	IN	denotes	in
T13058	19714-19717	DT	denotes	all
T13059	19718-19725	NNS	denotes	species
T13060	19726-19734	VBN	denotes	examined
T13061	19735-19737	IN	denotes	to
T13062	19738-19742	NN	denotes	date
T13063	19742-19743	.	denotes	.
T13064	19743-19819	sentence	denotes	This motif is characteristically encoded by the 3' exons of the TACC genes.
T13065	19744-19748	DT	denotes	This
T13066	19749-19754	NN	denotes	motif
T13068	19755-19757	VBZ	denotes	is
T13069	19758-19776	RB	denotes	characteristically
T13067	19777-19784	VBN	denotes	encoded
T13070	19785-19787	IN	denotes	by
T13071	19788-19791	DT	denotes	the
T13073	19792-19793	CD	denotes	3
T13074	19793-19794	SYM	denotes	'
T13072	19795-19800	NNS	denotes	exons
T13075	19801-19803	IN	denotes	of
T13076	19804-19807	DT	denotes	the
T13078	19808-19812	NN	denotes	TACC
T13077	19813-19818	NNS	denotes	genes
T13079	19818-19819	.	denotes	.
T13080	19819-19875	sentence	denotes	The size of the largest isoform for each gene is shown.
T13081	19820-19823	DT	denotes	The
T13082	19824-19828	NN	denotes	size
T13084	19829-19831	IN	denotes	of
T13085	19832-19835	DT	denotes	the
T13087	19836-19843	JJS	denotes	largest
T13086	19844-19851	NN	denotes	isoform
T13088	19852-19855	IN	denotes	for
T13089	19856-19860	DT	denotes	each
T13090	19861-19865	NN	denotes	gene
T13091	19866-19868	VBZ	denotes	is
T13083	19869-19874	VBN	denotes	shown
T13092	19874-19875	.	denotes	.
T5507	19877-19888	JJ	denotes	Comparative
T5509	19889-19896	JJ	denotes	genomic
T5508	19897-19906	NN	denotes	structure
T5510	19907-19909	IN	denotes	of
T5511	19910-19913	DT	denotes	the
T5513	19914-19918	NN	denotes	TACC
T5512	19919-19925	NN	denotes	family
T5514	19925-20181	sentence	denotes	The genomic DNA sequences corresponding to the orthologous TACC genes of human, mouse, rat, pufferfish, C. intestinalis, D. melanogaster and C. elegans were extracted and analyzed by Genescan and BLAST to determine the genomic structure of each TACC gene.
T5515	19926-19929	DT	denotes	The
T5517	19930-19937	JJ	denotes	genomic
T5518	19938-19941	NN	denotes	DNA
T5516	19942-19951	NNS	denotes	sequences
T5520	19952-19965	VBG	denotes	corresponding
T5521	19966-19968	IN	denotes	to
T5522	19969-19972	DT	denotes	the
T5524	19973-19984	JJ	denotes	orthologous
T5525	19985-19989	NN	denotes	TACC
T5523	19990-19995	NNS	denotes	genes
T5526	19996-19998	IN	denotes	of
T5527	19999-20004	JJ	denotes	human
T5528	20004-20006	,	denotes	,
T5529	20006-20011	NN	denotes	mouse
T5530	20011-20013	,	denotes	,
T5531	20013-20016	NN	denotes	rat
T5532	20016-20018	,	denotes	,
T5533	20018-20028	NN	denotes	pufferfish
T5534	20028-20030	,	denotes	,
T5535	20030-20032	NNP	denotes	C.
T5536	20033-20045	NNP	denotes	intestinalis
T5537	20045-20047	,	denotes	,
T5538	20047-20049	NNP	denotes	D.
T5539	20050-20062	NNP	denotes	melanogaster
T5540	20063-20066	CC	denotes	and
T5541	20067-20069	NNP	denotes	C.
T5542	20070-20077	NNP	denotes	elegans
T5543	20078-20082	VBD	denotes	were
T5519	20083-20092	VBN	denotes	extracted
T5544	20093-20096	CC	denotes	and
T5545	20097-20105	VBN	denotes	analyzed
T5546	20106-20108	IN	denotes	by
T5547	20109-20117	NNP	denotes	Genescan
T5548	20118-20121	CC	denotes	and
T5549	20122-20127	NNP	denotes	BLAST
T5550	20128-20130	TO	denotes	to
T5551	20131-20140	VB	denotes	determine
T5552	20141-20144	DT	denotes	the
T5554	20145-20152	JJ	denotes	genomic
T5553	20153-20162	NN	denotes	structure
T5555	20163-20165	IN	denotes	of
T5556	20166-20170	DT	denotes	each
T5558	20171-20175	NN	denotes	TACC
T5557	20176-20180	NN	denotes	gene
T5559	20180-20181	.	denotes	.
T5560	20181-20348	sentence	denotes	In some cases, for rat and pufferfish, exons were added or modified based on the best similarity of translated peptides to the corresponding mouse and human proteins.
T5561	20182-20184	IN	denotes	In
T5563	20185-20189	DT	denotes	some
T5564	20190-20195	NNS	denotes	cases
T5565	20195-20197	,	denotes	,
T5566	20197-20200	IN	denotes	for
T5567	20201-20204	NN	denotes	rat
T5568	20205-20208	CC	denotes	and
T5569	20209-20219	NN	denotes	pufferfish
T5570	20219-20221	,	denotes	,
T5571	20221-20226	NNS	denotes	exons
T5572	20227-20231	VBD	denotes	were
T5562	20232-20237	VBN	denotes	added
T5573	20238-20240	CC	denotes	or
T5574	20241-20249	VBN	denotes	modified
T5575	20250-20255	VBN	denotes	based
T5576	20256-20258	IN	denotes	on
T5577	20259-20262	DT	denotes	the
T5579	20263-20267	JJS	denotes	best
T5578	20268-20278	NN	denotes	similarity
T5580	20279-20281	IN	denotes	of
T5581	20282-20292	VBN	denotes	translated
T5582	20293-20301	NNS	denotes	peptides
T5583	20302-20304	IN	denotes	to
T5584	20305-20308	DT	denotes	the
T5586	20309-20322	VBG	denotes	corresponding
T5587	20323-20328	NN	denotes	mouse
T5588	20329-20332	CC	denotes	and
T5589	20333-20338	JJ	denotes	human
T5585	20339-20347	NN	denotes	proteins
T5590	20347-20348	.	denotes	.
T5591	20348-20541	sentence	denotes	For regions with low sequence similarity in T. rubripes, genomic sequences from the fresh water pufferfish, Tetraodon nigroviridis were used as additional means to verify the predicted exons.
T5592	20349-20352	IN	denotes	For
T5594	20353-20360	NNS	denotes	regions
T5595	20361-20365	IN	denotes	with
T5596	20366-20369	JJ	denotes	low
T5598	20370-20378	NN	denotes	sequence
T5597	20379-20389	NN	denotes	similarity
T5599	20390-20392	IN	denotes	in
T5600	20393-20395	NNP	denotes	T.
T5601	20396-20404	NNP	denotes	rubripes
T5602	20404-20406	,	denotes	,
T5603	20406-20413	JJ	denotes	genomic
T5604	20414-20423	NNS	denotes	sequences
T5605	20425-20429	IN	denotes	from
T5606	20430-20433	DT	denotes	the
T5608	20434-20439	JJ	denotes	fresh
T5609	20440-20445	NN	denotes	water
T5607	20446-20456	NN	denotes	pufferfish
T5610	20456-20458	,	denotes	,
T5611	20458-20467	NNP	denotes	Tetraodon
T5612	20468-20480	NNP	denotes	nigroviridis
T5613	20481-20485	VBD	denotes	were
T5593	20486-20490	VBN	denotes	used
T5614	20491-20493	IN	denotes	as
T5615	20494-20504	JJ	denotes	additional
T5616	20505-20510	NNS	denotes	means
T5617	20511-20513	TO	denotes	to
T5618	20514-20520	VB	denotes	verify
T5619	20521-20524	DT	denotes	the
T5621	20525-20534	VBN	denotes	predicted
T5620	20535-20540	NNS	denotes	exons
T5622	20540-20541	.	denotes	.
T5623	20541-20617	sentence	denotes	The general structure of the TACC genes and proteins is depicted in Fig. 4.
T5624	20542-20545	DT	denotes	The
T5626	20546-20553	JJ	denotes	general
T5625	20554-20563	NN	denotes	structure
T5628	20564-20566	IN	denotes	of
T5629	20567-20570	DT	denotes	the
T5631	20571-20575	NN	denotes	TACC
T5630	20576-20581	NNS	denotes	genes
T5632	20582-20585	CC	denotes	and
T5633	20586-20594	NN	denotes	proteins
T5634	20595-20597	VBZ	denotes	is
T5627	20598-20606	VBN	denotes	depicted
T5635	20607-20609	IN	denotes	in
T5636	20610-20614	NN	denotes	Fig.
T5637	20615-20616	CD	denotes	4
T5638	20616-20617	.	denotes	.
T5639	20617-20732	sentence	denotes	The main conserved feature of the TACC family, the TACC domain, is located at the carboxy terminus of the protein.
T5640	20618-20621	DT	denotes	The
T5642	20622-20626	JJ	denotes	main
T5643	20627-20636	VBN	denotes	conserved
T5641	20637-20644	NN	denotes	feature
T5645	20645-20647	IN	denotes	of
T5646	20648-20651	DT	denotes	the
T5648	20652-20656	NN	denotes	TACC
T5647	20657-20663	NN	denotes	family
T5649	20663-20665	,	denotes	,
T5650	20665-20668	DT	denotes	the
T5652	20669-20673	NN	denotes	TACC
T5651	20674-20680	NN	denotes	domain
T5653	20680-20682	,	denotes	,
T5654	20682-20684	VBZ	denotes	is
T5644	20685-20692	VBN	denotes	located
T5655	20693-20695	IN	denotes	at
T5656	20696-20699	DT	denotes	the
T5658	20700-20707	NN	denotes	carboxy
T5657	20708-20716	NN	denotes	terminus
T5659	20717-20719	IN	denotes	of
T5660	20720-20723	DT	denotes	the
T5661	20724-20731	NN	denotes	protein
T5662	20731-20732	.	denotes	.
T5663	20732-20882	sentence	denotes	In the case of the C. elegans TAC protein, this structure comprises the majority of the protein and is encoded by two of the three exons of the gene.
T5664	20733-20735	IN	denotes	In
T5666	20736-20739	DT	denotes	the
T5667	20740-20744	NN	denotes	case
T5668	20745-20747	IN	denotes	of
T5669	20748-20751	DT	denotes	the
T5671	20752-20754	NNP	denotes	C.
T5672	20755-20762	NNP	denotes	elegans
T5673	20763-20766	NN	denotes	TAC
T5670	20767-20774	NN	denotes	protein
T5674	20774-20776	,	denotes	,
T5675	20776-20780	DT	denotes	this
T5676	20781-20790	NN	denotes	structure
T5665	20791-20800	VBZ	denotes	comprises
T5677	20801-20804	DT	denotes	the
T5678	20805-20813	NN	denotes	majority
T5679	20814-20816	IN	denotes	of
T5680	20817-20820	DT	denotes	the
T5681	20821-20828	NN	denotes	protein
T5682	20829-20832	CC	denotes	and
T5683	20833-20835	VBZ	denotes	is
T5684	20836-20843	VBN	denotes	encoded
T5685	20844-20846	IN	denotes	by
T5686	20847-20850	CD	denotes	two
T5687	20851-20853	IN	denotes	of
T5688	20854-20857	DT	denotes	the
T5690	20858-20863	CD	denotes	three
T5689	20864-20869	NNS	denotes	exons
T5691	20870-20872	IN	denotes	of
T5692	20873-20876	DT	denotes	the
T5693	20877-20881	NN	denotes	gene
T5694	20881-20882	.	denotes	.
T5695	20882-21092	sentence	denotes	In the higher organisms, D. melanogaster, and the deuterostomes C. intestinalis to human, this feature is also encoded by the final exons of the gene (five in D. melanogaster, seven in the deuterostome genes).
T5696	20883-20885	IN	denotes	In
T5698	20886-20889	DT	denotes	the
T5700	20890-20896	JJR	denotes	higher
T5699	20897-20906	NNS	denotes	organisms
T5701	20906-20908	,	denotes	,
T5702	20908-20910	NNP	denotes	D.
T5703	20911-20923	NNP	denotes	melanogaster
T5704	20923-20925	,	denotes	,
T5705	20925-20928	CC	denotes	and
T5706	20929-20932	DT	denotes	the
T5708	20933-20946	NNS	denotes	deuterostomes
T5709	20947-20949	NNP	denotes	C.
T5707	20950-20962	NNP	denotes	intestinalis
T5710	20963-20965	IN	denotes	to
T5711	20966-20971	JJ	denotes	human
T5712	20971-20973	,	denotes	,
T5713	20973-20977	DT	denotes	this
T5714	20978-20985	NN	denotes	feature
T5715	20986-20988	VBZ	denotes	is
T5716	20989-20993	RB	denotes	also
T5697	20994-21001	VBN	denotes	encoded
T5717	21002-21004	IN	denotes	by
T5718	21005-21008	DT	denotes	the
T5720	21009-21014	JJ	denotes	final
T5719	21015-21020	NNS	denotes	exons
T5721	21021-21023	IN	denotes	of
T5722	21024-21027	DT	denotes	the
T5723	21028-21032	NN	denotes	gene
T5724	21033-21034	-LRB-	denotes	(
T5725	21034-21038	CD	denotes	five
T5726	21039-21041	IN	denotes	in
T5727	21042-21044	NNP	denotes	D.
T5728	21045-21057	NNP	denotes	melanogaster
T5729	21057-21059	,	denotes	,
T5730	21059-21064	CD	denotes	seven
T5731	21065-21067	IN	denotes	in
T5732	21068-21071	DT	denotes	the
T5734	21072-21084	NN	denotes	deuterostome
T5733	21085-21090	NNS	denotes	genes
T5735	21090-21091	-RRB-	denotes	)
T5736	21091-21092	.	denotes	.
T5737	21092-21182	sentence	denotes	Outside of the TACC domain, however, TACC family members show relatively little homology.
T5738	21093-21100	IN	denotes	Outside
T5740	21101-21103	IN	denotes	of
T5741	21104-21107	DT	denotes	the
T5743	21108-21112	NN	denotes	TACC
T5742	21113-21119	NN	denotes	domain
T5744	21119-21121	,	denotes	,
T5745	21121-21128	RB	denotes	however
T5746	21128-21130	,	denotes	,
T5747	21130-21134	NN	denotes	TACC
T5749	21135-21141	NN	denotes	family
T5748	21142-21149	NNS	denotes	members
T5739	21150-21154	VBP	denotes	show
T5750	21155-21165	RB	denotes	relatively
T5751	21166-21172	JJ	denotes	little
T5752	21173-21181	NN	denotes	homology
T5753	21181-21182	.	denotes	.
T5754	21182-21400	sentence	denotes	It is interesting that each TACC gene contains one large exon, which shows considerable variability between TACC orthologues, and constitutes the main difference between the TACC3 genes in the vertebrates (see below).
T5755	21183-21185	PRP	denotes	It
T5756	21186-21188	VBZ	denotes	is
T5757	21189-21200	JJ	denotes	interesting
T5758	21201-21205	IN	denotes	that
T5760	21206-21210	DT	denotes	each
T5762	21211-21215	NN	denotes	TACC
T5761	21216-21220	NN	denotes	gene
T5759	21221-21229	VBZ	denotes	contains
T5763	21230-21233	CD	denotes	one
T5765	21234-21239	JJ	denotes	large
T5764	21240-21244	NN	denotes	exon
T5766	21244-21246	,	denotes	,
T5767	21246-21251	WDT	denotes	which
T5768	21252-21257	VBZ	denotes	shows
T5769	21258-21270	JJ	denotes	considerable
T5770	21271-21282	NN	denotes	variability
T5771	21283-21290	IN	denotes	between
T5772	21291-21295	NN	denotes	TACC
T5773	21296-21307	NNS	denotes	orthologues
T5774	21307-21309	,	denotes	,
T5775	21309-21312	CC	denotes	and
T5776	21313-21324	VBZ	denotes	constitutes
T5777	21325-21328	DT	denotes	the
T5779	21329-21333	JJ	denotes	main
T5778	21334-21344	NN	denotes	difference
T5780	21345-21352	IN	denotes	between
T5781	21353-21356	DT	denotes	the
T5783	21357-21362	NN	denotes	TACC3
T5782	21363-21368	NNS	denotes	genes
T5784	21369-21371	IN	denotes	in
T5785	21372-21375	DT	denotes	the
T5786	21376-21387	NNS	denotes	vertebrates
T5787	21388-21389	-LRB-	denotes	(
T5788	21389-21392	VB	denotes	see
T5789	21393-21398	RB	denotes	below
T5790	21398-21399	-RRB-	denotes	)
T5791	21399-21400	.	denotes	.
T5792	21400-21638	sentence	denotes	In deuterostomes, this exon contains the SDP repeat (or in the case of the murine TACC3's, a rodent-specific 24 amino acid repeat), which is responsible for the binding of the SWI/SNF chromatin remodeling complex component GAS41 [15,16].
T5793	21401-21403	IN	denotes	In
T5795	21404-21417	NNS	denotes	deuterostomes
T5796	21417-21419	,	denotes	,
T5797	21419-21423	DT	denotes	this
T5798	21424-21428	NN	denotes	exon
T5794	21429-21437	VBZ	denotes	contains
T5799	21438-21441	DT	denotes	the
T5801	21442-21445	NN	denotes	SDP
T5800	21446-21452	NN	denotes	repeat
T5802	21453-21454	-LRB-	denotes	(
T5803	21454-21456	CC	denotes	or
T5804	21457-21459	IN	denotes	in
T5806	21460-21463	DT	denotes	the
T5807	21464-21468	NN	denotes	case
T5808	21469-21471	IN	denotes	of
T5809	21472-21475	DT	denotes	the
T5811	21476-21482	JJ	denotes	murine
T5810	21483-21488	NN	denotes	TACC3
T5812	21488-21490	POS	denotes	's
T5813	21490-21492	,	denotes	,
T5814	21492-21493	DT	denotes	a
T5815	21494-21500	NN	denotes	rodent
T5817	21500-21501	HYPH	denotes	-
T5816	21501-21509	JJ	denotes	specific
T5818	21510-21512	CD	denotes	24
T5820	21513-21518	NN	denotes	amino
T5819	21519-21523	NN	denotes	acid
T5805	21524-21530	NN	denotes	repeat
T5821	21530-21531	-RRB-	denotes	)
T5822	21531-21533	,	denotes	,
T5823	21533-21538	WDT	denotes	which
T5824	21539-21541	VBZ	denotes	is
T5825	21542-21553	JJ	denotes	responsible
T5826	21554-21557	IN	denotes	for
T5827	21558-21561	DT	denotes	the
T5828	21562-21569	NN	denotes	binding
T5829	21570-21572	IN	denotes	of
T5830	21573-21576	DT	denotes	the
T5832	21577-21580	NN	denotes	SWI
T5834	21580-21581	HYPH	denotes	/
T5833	21581-21584	NN	denotes	SNF
T5835	21585-21594	NN	denotes	chromatin
T5836	21595-21605	NN	denotes	remodeling
T5837	21606-21613	JJ	denotes	complex
T5831	21614-21623	NN	denotes	component
T5838	21624-21629	NN	denotes	GAS41
T5839	21630-21631	-LRB-	denotes	[
T5841	21631-21633	CD	denotes	15
T5842	21633-21634	,	denotes	,
T5840	21634-21636	CD	denotes	16
T5843	21636-21637	-RRB-	denotes	]
T5844	21637-21638	.	denotes	.
T5845	21638-21856	sentence	denotes	Of the vertebrate TACC proteins, the TACC3 orthologues show the greatest variability in size and sequence, ranging in size from 599 amino acids for the rat TACC3 protein, to 942 amino acids in the Danio rerio protein.
T5846	21639-21641	IN	denotes	Of
T5848	21642-21645	DT	denotes	the
T5850	21646-21656	NN	denotes	vertebrate
T5851	21657-21661	NN	denotes	TACC
T5849	21662-21670	NN	denotes	proteins
T5852	21670-21672	,	denotes	,
T5853	21672-21675	DT	denotes	the
T5855	21676-21681	NN	denotes	TACC3
T5854	21682-21693	NNS	denotes	orthologues
T5847	21694-21698	VBP	denotes	show
T5856	21699-21702	DT	denotes	the
T5858	21703-21711	JJS	denotes	greatest
T5857	21712-21723	NN	denotes	variability
T5859	21724-21726	IN	denotes	in
T5860	21727-21731	NN	denotes	size
T5861	21732-21735	CC	denotes	and
T5862	21736-21744	NN	denotes	sequence
T5863	21744-21746	,	denotes	,
T5864	21746-21753	VBG	denotes	ranging
T5865	21754-21756	IN	denotes	in
T5866	21757-21761	NN	denotes	size
T5867	21762-21766	IN	denotes	from
T5868	21767-21770	CD	denotes	599
T5870	21771-21776	NN	denotes	amino
T5869	21777-21782	NNS	denotes	acids
T5871	21783-21786	IN	denotes	for
T5872	21787-21790	DT	denotes	the
T5874	21791-21794	NN	denotes	rat
T5875	21795-21800	NN	denotes	TACC3
T5873	21801-21808	NN	denotes	protein
T5876	21808-21810	,	denotes	,
T5877	21810-21812	IN	denotes	to
T5878	21813-21816	CD	denotes	942
T5880	21817-21822	NN	denotes	amino
T5879	21823-21828	NNS	denotes	acids
T5881	21829-21831	IN	denotes	in
T5882	21832-21835	DT	denotes	the
T5884	21836-21841	NNP	denotes	Danio
T5885	21842-21847	NNP	denotes	rerio
T5883	21848-21855	NN	denotes	protein
T5886	21855-21856	.	denotes	.
T5887	21856-21956	sentence	denotes	The reasons for these differences are apparent from the genomic structure of the TACC3 orthologues.
T5888	21857-21860	DT	denotes	The
T5889	21861-21868	NNS	denotes	reasons
T5891	21869-21872	IN	denotes	for
T5892	21873-21878	DT	denotes	these
T5893	21879-21890	NNS	denotes	differences
T5890	21891-21894	VBP	denotes	are
T5894	21895-21903	JJ	denotes	apparent
T5895	21904-21908	IN	denotes	from
T5896	21909-21912	DT	denotes	the
T5898	21913-21920	JJ	denotes	genomic
T5897	21921-21930	NN	denotes	structure
T5899	21931-21933	IN	denotes	of
T5900	21934-21937	DT	denotes	the
T5902	21938-21943	NN	denotes	TACC3
T5901	21944-21955	NNS	denotes	orthologues
T5903	21955-21956	.	denotes	.
T5904	21956-22215	sentence	denotes	TACC3 can be divided into three sections: a conserved N-terminal region (CNTR) of 108 amino acids, encoded by exons 2 and 3 in each vertebrate TACC3 gene, the conserved TACC domain distributed over the final seven exons, and a highly variable central region.
T5905	21957-21962	NN	denotes	TACC3
T5907	21963-21966	MD	denotes	can
T5908	21967-21969	VB	denotes	be
T5906	21970-21977	VBN	denotes	divided
T5909	21978-21982	IN	denotes	into
T5910	21983-21988	CD	denotes	three
T5911	21989-21997	NNS	denotes	sections
T5912	21997-21999	:	denotes	:
T5913	21999-22000	DT	denotes	a
T5915	22001-22010	VBN	denotes	conserved
T5916	22011-22012	NN	denotes	N
T5918	22012-22013	HYPH	denotes	-
T5917	22013-22021	JJ	denotes	terminal
T5914	22022-22028	NN	denotes	region
T5919	22029-22030	-LRB-	denotes	(
T5920	22030-22034	NN	denotes	CNTR
T5921	22034-22035	-RRB-	denotes	)
T5922	22036-22038	IN	denotes	of
T5923	22039-22042	CD	denotes	108
T5925	22043-22048	NN	denotes	amino
T5924	22049-22054	NNS	denotes	acids
T5926	22054-22056	,	denotes	,
T5927	22056-22063	VBN	denotes	encoded
T5928	22064-22066	IN	denotes	by
T5929	22067-22072	NNS	denotes	exons
T5930	22073-22074	CD	denotes	2
T5931	22075-22078	CC	denotes	and
T5932	22079-22080	CD	denotes	3
T5933	22081-22083	IN	denotes	in
T5934	22084-22088	DT	denotes	each
T5936	22089-22099	NN	denotes	vertebrate
T5937	22100-22105	NN	denotes	TACC3
T5935	22106-22110	NN	denotes	gene
T5938	22110-22112	,	denotes	,
T5939	22112-22115	DT	denotes	the
T5941	22116-22125	VBN	denotes	conserved
T5942	22126-22130	NN	denotes	TACC
T5940	22131-22137	NN	denotes	domain
T5943	22138-22149	VBN	denotes	distributed
T5944	22150-22154	IN	denotes	over
T5945	22155-22158	DT	denotes	the
T5947	22159-22164	JJ	denotes	final
T5948	22165-22170	CD	denotes	seven
T5946	22171-22176	NNS	denotes	exons
T5949	22176-22178	,	denotes	,
T5950	22178-22181	CC	denotes	and
T5951	22182-22183	DT	denotes	a
T5953	22184-22190	RB	denotes	highly
T5954	22191-22199	JJ	denotes	variable
T5955	22200-22207	JJ	denotes	central
T5952	22208-22214	NN	denotes	region
T5956	22214-22215	.	denotes	.
T5957	22215-22430	sentence	denotes	The lack of conservation in both size and sequence of the central portion of the TACC3 proteins of human and mouse has been previously noted, and accounts for the major difference between these two orthologues [2].
T5958	22216-22219	DT	denotes	The
T5959	22220-22224	NN	denotes	lack
T5961	22225-22227	IN	denotes	of
T5962	22228-22240	NN	denotes	conservation
T5963	22241-22243	IN	denotes	in
T5964	22244-22248	CC	denotes	both
T5965	22249-22253	NN	denotes	size
T5966	22254-22257	CC	denotes	and
T5967	22258-22266	NN	denotes	sequence
T5968	22267-22269	IN	denotes	of
T5969	22270-22273	DT	denotes	the
T5971	22274-22281	JJ	denotes	central
T5970	22282-22289	NN	denotes	portion
T5972	22290-22292	IN	denotes	of
T5973	22293-22296	DT	denotes	the
T5975	22297-22302	NN	denotes	TACC3
T5974	22303-22311	NN	denotes	proteins
T5976	22312-22314	IN	denotes	of
T5977	22315-22320	JJ	denotes	human
T5979	22321-22324	CC	denotes	and
T5978	22325-22330	NN	denotes	mouse
T5980	22331-22334	VBZ	denotes	has
T5981	22335-22339	VBN	denotes	been
T5982	22340-22350	RB	denotes	previously
T5960	22351-22356	VBN	denotes	noted
T5983	22356-22358	,	denotes	,
T5984	22358-22361	CC	denotes	and
T5985	22362-22370	VBZ	denotes	accounts
T5986	22371-22374	IN	denotes	for
T5987	22375-22378	DT	denotes	the
T5989	22379-22384	JJ	denotes	major
T5988	22385-22395	NN	denotes	difference
T5990	22396-22403	IN	denotes	between
T5991	22404-22409	DT	denotes	these
T5993	22410-22413	CD	denotes	two
T5992	22414-22425	NNS	denotes	orthologues
T5994	22426-22427	-LRB-	denotes	[
T5995	22427-22428	CD	denotes	2
T5996	22428-22429	-RRB-	denotes	]
T5997	22429-22430	.	denotes	.
T5998	22430-22577	sentence	denotes	The majority of this central portion, which contains the SDP repeat motifs, is encoded by one exon in human and the pufferfish (emb\|CAAB01001184).
T5999	22431-22434	DT	denotes	The
T6000	22435-22443	NN	denotes	majority
T6002	22444-22446	IN	denotes	of
T6003	22447-22451	DT	denotes	this
T6005	22452-22459	JJ	denotes	central
T6004	22460-22467	NN	denotes	portion
T6006	22467-22469	,	denotes	,
T6007	22469-22474	WDT	denotes	which
T6008	22475-22483	VBZ	denotes	contains
T6009	22484-22487	DT	denotes	the
T6011	22488-22491	NN	denotes	SDP
T6012	22492-22498	NN	denotes	repeat
T6010	22499-22505	NNS	denotes	motifs
T6013	22505-22507	,	denotes	,
T6014	22507-22509	VBZ	denotes	is
T6001	22510-22517	VBN	denotes	encoded
T6015	22518-22520	IN	denotes	by
T6016	22521-22524	CD	denotes	one
T6017	22525-22529	NN	denotes	exon
T6018	22530-22532	IN	denotes	in
T6019	22533-22538	JJ	denotes	human
T6020	22539-22542	CC	denotes	and
T6021	22543-22546	DT	denotes	the
T6022	22547-22557	NN	denotes	pufferfish
T6023	22558-22559	-LRB-	denotes	(
T6024	22559-22575	NN	denotes	emb\|CAAB01001184
T6025	22575-22576	-RRB-	denotes	)
T6026	22576-22577	.	denotes	.
T6027	22577-22739	sentence	denotes	In rodents, however, this region is almost entirely composed of seven 24 amino acid repeats, which are located in a single exon of the mouse and rat TACC3 genes.
T6028	22578-22580	IN	denotes	In
T6030	22581-22588	NNS	denotes	rodents
T6031	22588-22590	,	denotes	,
T6032	22590-22597	RB	denotes	however
T6033	22597-22599	,	denotes	,
T6034	22599-22603	DT	denotes	this
T6035	22604-22610	NN	denotes	region
T6036	22611-22613	VBZ	denotes	is
T6037	22614-22620	RB	denotes	almost
T6038	22621-22629	RB	denotes	entirely
T6029	22630-22638	VBN	denotes	composed
T6039	22639-22641	IN	denotes	of
T6040	22642-22647	CD	denotes	seven
T6042	22648-22650	CD	denotes	24
T6044	22651-22656	NN	denotes	amino
T6043	22657-22661	NN	denotes	acid
T6041	22662-22669	NNS	denotes	repeats
T6045	22669-22671	,	denotes	,
T6046	22671-22676	WDT	denotes	which
T6048	22677-22680	VBP	denotes	are
T6047	22681-22688	VBN	denotes	located
T6049	22689-22691	IN	denotes	in
T6050	22692-22693	DT	denotes	a
T6052	22694-22700	JJ	denotes	single
T6051	22701-22705	NN	denotes	exon
T6053	22706-22708	IN	denotes	of
T6054	22709-22712	DT	denotes	the
T6056	22713-22718	NN	denotes	mouse
T6057	22719-22722	CC	denotes	and
T6058	22723-22726	NN	denotes	rat
T6059	22727-22732	NN	denotes	TACC3
T6055	22733-22738	NNS	denotes	genes
T6060	22738-22739	.	denotes	.
T6061	22739-22872	sentence	denotes	It has been previously reported that there are four mouse TACC3 splice variants that differ in the number of these repeats [2,7,17].
T6062	22740-22742	PRP	denotes	It
T6064	22743-22746	VBZ	denotes	has
T6065	22747-22751	VBN	denotes	been
T6066	22752-22762	RB	denotes	previously
T6063	22763-22771	VBN	denotes	reported
T6067	22772-22776	IN	denotes	that
T6069	22777-22782	EX	denotes	there
T6068	22783-22786	VBP	denotes	are
T6070	22787-22791	CD	denotes	four
T6072	22792-22797	NN	denotes	mouse
T6073	22798-22803	NN	denotes	TACC3
T6074	22804-22810	NN	denotes	splice
T6071	22811-22819	NNS	denotes	variants
T6075	22820-22824	WDT	denotes	that
T6076	22825-22831	VBP	denotes	differ
T6077	22832-22834	IN	denotes	in
T6078	22835-22838	DT	denotes	the
T6079	22839-22845	NN	denotes	number
T6080	22846-22848	IN	denotes	of
T6081	22849-22854	DT	denotes	these
T6082	22855-22862	NNS	denotes	repeats
T6083	22863-22864	-LRB-	denotes	[
T6085	22864-22865	CD	denotes	2
T6086	22865-22866	,	denotes	,
T6087	22866-22867	CD	denotes	7
T6088	22867-22868	,	denotes	,
T6084	22868-22870	CD	denotes	17
T6089	22870-22871	-RRB-	denotes	]
T6090	22871-22872	.	denotes	.
T6091	22872-23093	sentence	denotes	As these repeats are present in a single exon, it appears likely that these different sequences may be the result of the DNA polymerases used in the cDNA synthesis and/or PCR reaction stuttering through the repeat motif.
T6092	22873-22875	IN	denotes	As
T6094	22876-22881	DT	denotes	these
T6095	22882-22889	NNS	denotes	repeats
T6093	22890-22893	VBP	denotes	are
T6097	22894-22901	JJ	denotes	present
T6098	22902-22904	IN	denotes	in
T6099	22905-22906	DT	denotes	a
T6101	22907-22913	JJ	denotes	single
T6100	22914-22918	NN	denotes	exon
T6102	22918-22920	,	denotes	,
T6103	22920-22922	PRP	denotes	it
T6096	22923-22930	VBZ	denotes	appears
T6104	22931-22937	JJ	denotes	likely
T6105	22938-22942	IN	denotes	that
T6107	22943-22948	DT	denotes	these
T6109	22949-22958	JJ	denotes	different
T6108	22959-22968	NNS	denotes	sequences
T6110	22969-22972	MD	denotes	may
T6106	22973-22975	VB	denotes	be
T6111	22976-22979	DT	denotes	the
T6112	22980-22986	NN	denotes	result
T6113	22987-22989	IN	denotes	of
T6114	22990-22993	DT	denotes	the
T6116	22994-22997	NN	denotes	DNA
T6115	22998-23009	NNS	denotes	polymerases
T6117	23010-23014	VBN	denotes	used
T6118	23015-23017	IN	denotes	in
T6119	23018-23021	DT	denotes	the
T6121	23022-23026	NN	denotes	cDNA
T6120	23027-23036	NN	denotes	synthesis
T6122	23037-23040	CC	denotes	and
T6123	23040-23041	HYPH	denotes	/
T6124	23041-23043	CC	denotes	or
T6125	23044-23047	NN	denotes	PCR
T6126	23048-23056	NN	denotes	reaction
T6127	23057-23067	VBG	denotes	stuttering
T6128	23068-23075	IN	denotes	through
T6129	23076-23079	DT	denotes	the
T6131	23080-23086	NN	denotes	repeat
T6130	23087-23092	NN	denotes	motif
T6132	23092-23093	.	denotes	.
T6133	23093-23204	sentence	denotes	The correct sequence, reported by Sadek et al [7], is the one used throughout the entirety of this manuscript.
T6134	23094-23097	DT	denotes	The
T6136	23098-23105	JJ	denotes	correct
T6135	23106-23114	NN	denotes	sequence
T6138	23114-23116	,	denotes	,
T6139	23116-23124	VBN	denotes	reported
T6140	23125-23127	IN	denotes	by
T6141	23128-23133	NNP	denotes	Sadek
T6142	23134-23136	FW	denotes	et
T6143	23137-23139	FW	denotes	al
T6144	23140-23141	-LRB-	denotes	[
T6145	23141-23142	CD	denotes	7
T6146	23142-23143	-RRB-	denotes	]
T6147	23143-23145	,	denotes	,
T6137	23145-23147	VBZ	denotes	is
T6148	23148-23151	DT	denotes	the
T6149	23152-23155	CD	denotes	one
T6150	23156-23160	VBN	denotes	used
T6151	23161-23171	IN	denotes	throughout
T6152	23172-23175	DT	denotes	the
T6153	23176-23184	NN	denotes	entirety
T6154	23185-23187	IN	denotes	of
T6155	23188-23192	DT	denotes	this
T6156	23193-23203	NN	denotes	manuscript
T6157	23203-23204	.	denotes	.
T6158	23204-23426	sentence	denotes	These repeats are not evident in the rabbit protein, or any other TACC protein, and may indicate that the rodent TACC3 has evolved distinct functions, as has already been noted for the amphibian Xenopus TACC3, maskin [8].
T6159	23205-23210	DT	denotes	These
T6160	23211-23218	NNS	denotes	repeats
T6161	23219-23222	VBP	denotes	are
T6162	23223-23226	RB	denotes	not
T6163	23227-23234	JJ	denotes	evident
T6164	23235-23237	IN	denotes	in
T6165	23238-23241	DT	denotes	the
T6167	23242-23248	NN	denotes	rabbit
T6166	23249-23256	NN	denotes	protein
T6168	23256-23258	,	denotes	,
T6169	23258-23260	CC	denotes	or
T6170	23261-23264	DT	denotes	any
T6172	23265-23270	JJ	denotes	other
T6173	23271-23275	NN	denotes	TACC
T6171	23276-23283	NN	denotes	protein
T6174	23283-23285	,	denotes	,
T6175	23285-23288	CC	denotes	and
T6176	23289-23292	MD	denotes	may
T6177	23293-23301	VB	denotes	indicate
T6178	23302-23306	IN	denotes	that
T6180	23307-23310	DT	denotes	the
T6182	23311-23317	NN	denotes	rodent
T6181	23318-23323	NN	denotes	TACC3
T6183	23324-23327	VBZ	denotes	has
T6179	23328-23335	VBN	denotes	evolved
T6184	23336-23344	JJ	denotes	distinct
T6185	23345-23354	NNS	denotes	functions
T6186	23354-23356	,	denotes	,
T6187	23356-23358	IN	denotes	as
T6189	23359-23362	VBZ	denotes	has
T6190	23363-23370	RB	denotes	already
T6191	23371-23375	VBN	denotes	been
T6188	23376-23381	VBN	denotes	noted
T6192	23382-23385	IN	denotes	for
T6193	23386-23389	DT	denotes	the
T6195	23390-23399	JJ	denotes	amphibian
T6196	23400-23407	NNP	denotes	Xenopus
T6194	23408-23413	NN	denotes	TACC3
T6197	23413-23415	,	denotes	,
T6198	23415-23421	NN	denotes	maskin
T6199	23422-23423	-LRB-	denotes	[
T6200	23423-23424	CD	denotes	8
T6201	23424-23425	-RRB-	denotes	]
T6202	23425-23426	.	denotes	.
T6381	23428-23439	JJ	denotes	Alternative
T6382	23440-23448	NN	denotes	splicing
T6383	23449-23451	IN	denotes	in
T6384	23452-23462	NN	denotes	vertebrate
T6386	23463-23467	NN	denotes	TACC
T6385	23468-23473	NNS	denotes	genes
T6387	23473-23745	sentence	denotes	Whereas exon shuffling can drive the functional diversification of gene families over evolutionary time, the temporal and/or tissue specific alternative splicing of a gene can give rise to functional diversification of a single gene during the development of an organism.
T6388	23474-23481	IN	denotes	Whereas
T6390	23482-23486	NN	denotes	exon
T6391	23487-23496	NN	denotes	shuffling
T6392	23497-23500	MD	denotes	can
T6389	23501-23506	VB	denotes	drive
T6394	23507-23510	DT	denotes	the
T6396	23511-23521	JJ	denotes	functional
T6395	23522-23537	NN	denotes	diversification
T6397	23538-23540	IN	denotes	of
T6398	23541-23545	NN	denotes	gene
T6399	23546-23554	NNS	denotes	families
T6400	23555-23559	IN	denotes	over
T6401	23560-23572	JJ	denotes	evolutionary
T6402	23573-23577	NN	denotes	time
T6403	23577-23579	,	denotes	,
T6404	23579-23582	DT	denotes	the
T6406	23583-23591	JJ	denotes	temporal
T6407	23592-23595	CC	denotes	and
T6408	23595-23596	HYPH	denotes	/
T6409	23596-23598	CC	denotes	or
T6410	23599-23605	NN	denotes	tissue
T6411	23606-23614	JJ	denotes	specific
T6412	23615-23626	JJ	denotes	alternative
T6405	23627-23635	NN	denotes	splicing
T6413	23636-23638	IN	denotes	of
T6414	23639-23640	DT	denotes	a
T6415	23641-23645	NN	denotes	gene
T6416	23646-23649	MD	denotes	can
T6393	23650-23654	VB	denotes	give
T6417	23655-23659	NN	denotes	rise
T6418	23660-23662	IN	denotes	to
T6419	23663-23673	JJ	denotes	functional
T6420	23674-23689	NN	denotes	diversification
T6421	23690-23692	IN	denotes	of
T6422	23693-23694	DT	denotes	a
T6424	23695-23701	JJ	denotes	single
T6423	23702-23706	NN	denotes	gene
T6425	23707-23713	IN	denotes	during
T6426	23714-23717	DT	denotes	the
T6427	23718-23729	NN	denotes	development
T6428	23730-23732	IN	denotes	of
T6429	23733-23735	DT	denotes	an
T6430	23736-23744	NN	denotes	organism
T6431	23744-23745	.	denotes	.
T6432	23745-23901	sentence	denotes	Although no alternative splicing of TACC3 has been clearly documented, both temporal and tissue specific splicing is observed in the TACC1 and TACC2 genes.
T6433	23746-23754	IN	denotes	Although
T6435	23755-23757	DT	denotes	no
T6437	23758-23769	JJ	denotes	alternative
T6436	23770-23778	NN	denotes	splicing
T6438	23779-23781	IN	denotes	of
T6439	23782-23787	NN	denotes	TACC3
T6440	23788-23791	VBZ	denotes	has
T6441	23792-23796	VBN	denotes	been
T6442	23797-23804	RB	denotes	clearly
T6434	23805-23815	VBN	denotes	documented
T6444	23815-23817	,	denotes	,
T6445	23817-23821	CC	denotes	both
T6446	23822-23830	JJ	denotes	temporal
T6448	23831-23834	CC	denotes	and
T6449	23835-23841	NN	denotes	tissue
T6450	23842-23850	JJ	denotes	specific
T6447	23851-23859	NN	denotes	splicing
T6451	23860-23862	VBZ	denotes	is
T6443	23863-23871	VBN	denotes	observed
T6452	23872-23874	IN	denotes	in
T6453	23875-23878	DT	denotes	the
T6455	23879-23884	NN	denotes	TACC1
T6456	23885-23888	CC	denotes	and
T6457	23889-23894	NN	denotes	TACC2
T6454	23895-23900	NNS	denotes	genes
T6458	23900-23901	.	denotes	.
T6459	23901-24057	sentence	denotes	In the case of TACC2, an additional large (5 kb) exon accounts for the main difference between the major splice variants of the vertebrate TACC2 genes [3].
T6460	23902-23904	IN	denotes	In
T6462	23905-23908	DT	denotes	the
T6463	23909-23913	NN	denotes	case
T6464	23914-23916	IN	denotes	of
T6465	23917-23922	NN	denotes	TACC2
T6466	23922-23924	,	denotes	,
T6467	23924-23926	DT	denotes	an
T6469	23927-23937	JJ	denotes	additional
T6470	23938-23943	JJ	denotes	large
T6471	23944-23945	-LRB-	denotes	(
T6473	23945-23946	CD	denotes	5
T6472	23947-23949	NN	denotes	kb
T6474	23949-23950	-RRB-	denotes	)
T6468	23951-23955	NN	denotes	exon
T6461	23956-23964	VBZ	denotes	accounts
T6475	23965-23968	IN	denotes	for
T6476	23969-23972	DT	denotes	the
T6478	23973-23977	JJ	denotes	main
T6477	23978-23988	NN	denotes	difference
T6479	23989-23996	IN	denotes	between
T6480	23997-24000	DT	denotes	the
T6482	24001-24006	JJ	denotes	major
T6483	24007-24013	NN	denotes	splice
T6481	24014-24022	NNS	denotes	variants
T6484	24023-24025	IN	denotes	of
T6485	24026-24029	DT	denotes	the
T6487	24030-24040	NN	denotes	vertebrate
T6488	24041-24046	NN	denotes	TACC2
T6486	24047-24052	NNS	denotes	genes
T6489	24053-24054	-LRB-	denotes	[
T6490	24054-24055	CD	denotes	3
T6491	24055-24056	-RRB-	denotes	]
T6492	24056-24057	.	denotes	.
T6493	24057-24284	sentence	denotes	The alternative splicing of this exon suggests a major functional difference between the two TACC2 isoforms, TACC2s and TACC2l [3], as well as a significant difference between TACC2 and its closest TACC family relative, TACC1.
T6494	24058-24061	DT	denotes	The
T6496	24062-24073	JJ	denotes	alternative
T6495	24074-24082	NN	denotes	splicing
T6498	24083-24085	IN	denotes	of
T6499	24086-24090	DT	denotes	this
T6500	24091-24095	NN	denotes	exon
T6497	24096-24104	VBZ	denotes	suggests
T6501	24105-24106	DT	denotes	a
T6503	24107-24112	JJ	denotes	major
T6504	24113-24123	JJ	denotes	functional
T6502	24124-24134	NN	denotes	difference
T6505	24135-24142	IN	denotes	between
T6506	24143-24146	DT	denotes	the
T6508	24147-24150	CD	denotes	two
T6509	24151-24156	NN	denotes	TACC2
T6507	24157-24165	NNS	denotes	isoforms
T6510	24165-24167	,	denotes	,
T6511	24167-24173	NNS	denotes	TACC2s
T6512	24174-24177	CC	denotes	and
T6513	24178-24184	NN	denotes	TACC2l
T6514	24185-24186	-LRB-	denotes	[
T6515	24186-24187	CD	denotes	3
T6516	24187-24188	-RRB-	denotes	]
T6517	24188-24190	,	denotes	,
T6518	24190-24192	RB	denotes	as
T6520	24193-24197	RB	denotes	well
T6519	24198-24200	IN	denotes	as
T6521	24201-24202	DT	denotes	a
T6523	24203-24214	JJ	denotes	significant
T6522	24215-24225	NN	denotes	difference
T6524	24226-24233	IN	denotes	between
T6525	24234-24239	NN	denotes	TACC2
T6526	24240-24243	CC	denotes	and
T6527	24244-24247	PRP$	denotes	its
T6529	24248-24255	JJS	denotes	closest
T6530	24256-24260	NN	denotes	TACC
T6531	24261-24267	NN	denotes	family
T6528	24268-24276	NN	denotes	relative
T6532	24276-24278	,	denotes	,
T6533	24278-24283	NN	denotes	TACC1
T6534	24283-24284	.	denotes	.
T6535	24284-24363	sentence	denotes	However, the function of this region of the TACC2l isoform is current unknown.
T6536	24285-24292	RB	denotes	However
T6538	24292-24294	,	denotes	,
T6539	24294-24297	DT	denotes	the
T6540	24298-24306	NN	denotes	function
T6541	24307-24309	IN	denotes	of
T6542	24310-24314	DT	denotes	this
T6543	24315-24321	NN	denotes	region
T6544	24322-24324	IN	denotes	of
T6545	24325-24328	DT	denotes	the
T6547	24329-24335	NN	denotes	TACC2l
T6546	24336-24343	NN	denotes	isoform
T6537	24344-24346	VBZ	denotes	is
T6548	24347-24354	RB	denotes	current
T6549	24355-24362	JJ	denotes	unknown
T6550	24362-24363	.	denotes	.
T6551	24363-24484	sentence	denotes	Alternative splicing, together with differential promoter usage has already been noted for the human TACC1 gene [18,19].
T6552	24364-24375	JJ	denotes	Alternative
T6553	24376-24384	NN	denotes	splicing
T6555	24384-24386	,	denotes	,
T6556	24386-24394	RB	denotes	together
T6557	24395-24399	IN	denotes	with
T6558	24400-24412	JJ	denotes	differential
T6560	24413-24421	NN	denotes	promoter
T6559	24422-24427	NN	denotes	usage
T6561	24428-24431	VBZ	denotes	has
T6562	24432-24439	RB	denotes	already
T6563	24440-24444	VBN	denotes	been
T6554	24445-24450	VBN	denotes	noted
T6564	24451-24454	IN	denotes	for
T6565	24455-24458	DT	denotes	the
T6567	24459-24464	JJ	denotes	human
T6568	24465-24470	NN	denotes	TACC1
T6566	24471-24475	NN	denotes	gene
T6569	24476-24477	-LRB-	denotes	[
T6571	24477-24479	CD	denotes	18
T6572	24479-24480	,	denotes	,
T6570	24480-24482	CD	denotes	19
T6573	24482-24483	-RRB-	denotes	]
T6574	24483-24484	.	denotes	.
T6575	24484-24616	sentence	denotes	In addition, as shown in Fig. 5, we have identified additional TACC1 isoforms that result from alternative splicing of exons 1b-4a.
T6576	24485-24487	IN	denotes	In
T6578	24488-24496	NN	denotes	addition
T6579	24496-24498	,	denotes	,
T6580	24498-24500	IN	denotes	as
T6581	24501-24506	VBN	denotes	shown
T6582	24507-24509	IN	denotes	in
T6583	24510-24514	NN	denotes	Fig.
T6584	24515-24516	CD	denotes	5
T6585	24516-24518	,	denotes	,
T6586	24518-24520	PRP	denotes	we
T6587	24521-24525	VBP	denotes	have
T6577	24526-24536	VBN	denotes	identified
T6588	24537-24547	JJ	denotes	additional
T6590	24548-24553	NN	denotes	TACC1
T6589	24554-24562	NNS	denotes	isoforms
T6591	24563-24567	WDT	denotes	that
T6592	24568-24574	VBP	denotes	result
T6593	24575-24579	IN	denotes	from
T6594	24580-24591	JJ	denotes	alternative
T6595	24592-24600	NN	denotes	splicing
T6596	24601-24603	IN	denotes	of
T6597	24604-24609	NNS	denotes	exons
T6599	24610-24612	CD	denotes	1b
T6600	24612-24613	HYPH	denotes	-
T6598	24613-24615	CD	denotes	4a
T6601	24615-24616	.	denotes	.
T6602	24616-24900	sentence	denotes	The functions of these different isoforms are unknown, however the region deleted from the shorter variants can include the binding site for LSm7 [20] (variants C, D, F-I), and/or the nuclear localization signals and binding site for GAS41 [15] and PCTAIRE2BP [20] (isoforms B-D, S).
T6603	24617-24620	DT	denotes	The
T6604	24621-24630	NNS	denotes	functions
T6606	24631-24633	IN	denotes	of
T6607	24634-24639	DT	denotes	these
T6609	24640-24649	JJ	denotes	different
T6608	24650-24658	NNS	denotes	isoforms
T6605	24659-24662	VBP	denotes	are
T6611	24663-24670	JJ	denotes	unknown
T6612	24670-24672	,	denotes	,
T6613	24672-24679	RB	denotes	however
T6614	24680-24683	DT	denotes	the
T6615	24684-24690	NN	denotes	region
T6616	24691-24698	VBN	denotes	deleted
T6617	24699-24703	IN	denotes	from
T6618	24704-24707	DT	denotes	the
T6620	24708-24715	JJR	denotes	shorter
T6619	24716-24724	NNS	denotes	variants
T6621	24725-24728	MD	denotes	can
T6610	24729-24736	VB	denotes	include
T6622	24737-24740	DT	denotes	the
T6624	24741-24748	NN	denotes	binding
T6623	24749-24753	NN	denotes	site
T6625	24754-24757	IN	denotes	for
T6626	24758-24762	NN	denotes	LSm7
T6627	24763-24764	-LRB-	denotes	[
T6628	24764-24766	CD	denotes	20
T6629	24766-24767	-RRB-	denotes	]
T6630	24768-24769	-LRB-	denotes	(
T6632	24769-24777	NNS	denotes	variants
T6631	24778-24779	NN	denotes	C
T6633	24779-24781	,	denotes	,
T6634	24781-24782	NN	denotes	D
T6635	24782-24784	,	denotes	,
T6636	24784-24785	NN	denotes	F
T6637	24785-24786	SYM	denotes	-
T6638	24786-24787	NN	denotes	I
T6639	24787-24788	-RRB-	denotes	)
T6640	24788-24790	,	denotes	,
T6641	24790-24793	CC	denotes	and
T6642	24793-24794	HYPH	denotes	/
T6643	24794-24796	CC	denotes	or
T6644	24797-24800	DT	denotes	the
T6646	24801-24808	JJ	denotes	nuclear
T6647	24809-24821	NN	denotes	localization
T6645	24822-24829	NNS	denotes	signals
T6648	24830-24833	CC	denotes	and
T6649	24834-24841	NN	denotes	binding
T6650	24842-24846	NN	denotes	site
T6651	24847-24850	IN	denotes	for
T6652	24851-24856	NN	denotes	GAS41
T6653	24857-24858	-LRB-	denotes	[
T6654	24858-24860	CD	denotes	15
T6655	24860-24861	-RRB-	denotes	]
T6656	24862-24865	CC	denotes	and
T6657	24866-24876	NN	denotes	PCTAIRE2BP
T6658	24877-24878	-LRB-	denotes	[
T6659	24878-24880	CD	denotes	20
T6660	24880-24881	-RRB-	denotes	]
T6661	24882-24883	-LRB-	denotes	(
T6663	24883-24891	NNS	denotes	isoforms
T6662	24892-24893	NN	denotes	B
T6664	24893-24894	SYM	denotes	-
T6665	24894-24895	NN	denotes	D
T6666	24895-24897	,	denotes	,
T6667	24897-24898	NN	denotes	S
T6668	24898-24899	-RRB-	denotes	)
T6669	24899-24900	.	denotes	.
T6670	24900-25134	sentence	denotes	One of these isoforms, TACC1S is localized exclusively to the cytoplasm [19], suggesting that the shorter isoforms would not be able to interact with elements of the chomatin remodeling and/or RNA processing machinery in the nucleus.
T6671	24901-24904	CD	denotes	One
T6673	24905-24907	IN	denotes	of
T6674	24908-24913	DT	denotes	these
T6675	24914-24922	NNS	denotes	isoforms
T6676	24922-24924	,	denotes	,
T6677	24924-24930	NN	denotes	TACC1S
T6678	24931-24933	VBZ	denotes	is
T6672	24934-24943	VBN	denotes	localized
T6679	24944-24955	RB	denotes	exclusively
T6680	24956-24958	IN	denotes	to
T6681	24959-24962	DT	denotes	the
T6682	24963-24972	NN	denotes	cytoplasm
T6683	24973-24974	-LRB-	denotes	[
T6684	24974-24976	CD	denotes	19
T6685	24976-24977	-RRB-	denotes	]
T6686	24977-24979	,	denotes	,
T6687	24979-24989	VBG	denotes	suggesting
T6688	24990-24994	IN	denotes	that
T6690	24995-24998	DT	denotes	the
T6692	24999-25006	JJR	denotes	shorter
T6691	25007-25015	NNS	denotes	isoforms
T6693	25016-25021	MD	denotes	would
T6694	25022-25025	RB	denotes	not
T6689	25026-25028	VB	denotes	be
T6695	25029-25033	JJ	denotes	able
T6696	25034-25036	TO	denotes	to
T6697	25037-25045	VB	denotes	interact
T6698	25046-25050	IN	denotes	with
T6699	25051-25059	NNS	denotes	elements
T6700	25060-25062	IN	denotes	of
T6701	25063-25066	DT	denotes	the
T6703	25067-25075	NN	denotes	chomatin
T6702	25076-25086	NN	denotes	remodeling
T6704	25087-25090	CC	denotes	and
T6705	25090-25091	HYPH	denotes	/
T6706	25091-25093	CC	denotes	or
T6707	25094-25097	NN	denotes	RNA
T6709	25098-25108	NN	denotes	processing
T6708	25109-25118	NN	denotes	machinery
T6710	25119-25121	IN	denotes	in
T6711	25122-25125	DT	denotes	the
T6712	25126-25133	NN	denotes	nucleus
T6713	25133-25134	.	denotes	.
T6714	25134-25401	sentence	denotes	Thus, changes in the complement of TACC1 isoforms in the cell may result in alterations in cellular RNA metabolism at multiple levels, and may account for the observation that TACC1D and TACC1F isoforms are associated with tumorigenic changes in gastric mucosa [18].
T6715	25135-25139	RB	denotes	Thus
T6717	25139-25141	,	denotes	,
T6718	25141-25148	NNS	denotes	changes
T6719	25149-25151	IN	denotes	in
T6720	25152-25155	DT	denotes	the
T6721	25156-25166	NN	denotes	complement
T6722	25167-25169	IN	denotes	of
T6723	25170-25175	NN	denotes	TACC1
T6724	25176-25184	NNS	denotes	isoforms
T6725	25185-25187	IN	denotes	in
T6726	25188-25191	DT	denotes	the
T6727	25192-25196	NN	denotes	cell
T6728	25197-25200	MD	denotes	may
T6716	25201-25207	VB	denotes	result
T6729	25208-25210	IN	denotes	in
T6730	25211-25222	NNS	denotes	alterations
T6731	25223-25225	IN	denotes	in
T6732	25226-25234	JJ	denotes	cellular
T6734	25235-25238	NN	denotes	RNA
T6733	25239-25249	NN	denotes	metabolism
T6735	25250-25252	IN	denotes	at
T6736	25253-25261	JJ	denotes	multiple
T6737	25262-25268	NNS	denotes	levels
T6738	25268-25270	,	denotes	,
T6739	25270-25273	CC	denotes	and
T6740	25274-25277	MD	denotes	may
T6741	25278-25285	VB	denotes	account
T6742	25286-25289	IN	denotes	for
T6743	25290-25293	DT	denotes	the
T6744	25294-25305	NN	denotes	observation
T6745	25306-25310	IN	denotes	that
T6747	25311-25317	NN	denotes	TACC1D
T6749	25318-25321	CC	denotes	and
T6750	25322-25328	NN	denotes	TACC1F
T6748	25329-25337	NNS	denotes	isoforms
T6751	25338-25341	VBP	denotes	are
T6746	25342-25352	VBN	denotes	associated
T6752	25353-25357	IN	denotes	with
T6753	25358-25369	JJ	denotes	tumorigenic
T6754	25370-25377	NNS	denotes	changes
T6755	25378-25380	IN	denotes	in
T6756	25381-25388	JJ	denotes	gastric
T6757	25389-25395	NN	denotes	mucosa
T6758	25396-25397	-LRB-	denotes	[
T6759	25397-25399	CD	denotes	18
T6760	25399-25400	-RRB-	denotes	]
T6761	25400-25401	.	denotes	.
T13211	25412-25423	JJ	denotes	Alternative
T13212	25424-25432	NN	denotes	splicing
T13213	25433-25435	IN	denotes	of
T13214	25436-25439	DT	denotes	the
T13216	25440-25445	JJ	denotes	human
T13217	25446-25451	NN	denotes	TACC1
T13215	25452-25456	NN	denotes	gene
T13218	25456-25457	.	denotes	.
T13219	25457-25534	sentence	denotes	(A): Seven splice variants have been identified for human TACC1 (A-F and S).
T13220	25458-25459	-LRB-	denotes	(
T13221	25459-25460	LS	denotes	A
T13223	25460-25461	-RRB-	denotes	)
T13224	25461-25463	:	denotes	:
T13225	25463-25468	CD	denotes	Seven
T13227	25469-25475	NN	denotes	splice
T13226	25476-25484	NNS	denotes	variants
T13228	25485-25489	VBP	denotes	have
T13229	25490-25494	VBN	denotes	been
T13222	25495-25505	VBN	denotes	identified
T13230	25506-25509	IN	denotes	for
T13231	25510-25515	JJ	denotes	human
T13232	25516-25521	NN	denotes	TACC1
T13233	25522-25523	-LRB-	denotes	(
T13234	25523-25524	NN	denotes	A
T13235	25524-25525	SYM	denotes	-
T13236	25525-25526	NN	denotes	F
T13237	25527-25530	CC	denotes	and
T13238	25531-25532	NN	denotes	S
T13239	25532-25533	-RRB-	denotes	)
T13240	25533-25534	.	denotes	.
T13241	25534-25654	sentence	denotes	We have also identified additional splice variants (G-I) from database analysis and rt-PCR analysis of human brain RNA.
T13242	25535-25537	PRP	denotes	We
T13244	25538-25542	VBP	denotes	have
T13245	25543-25547	RB	denotes	also
T13243	25548-25558	VBN	denotes	identified
T13246	25559-25569	JJ	denotes	additional
T13248	25570-25576	NN	denotes	splice
T13247	25577-25585	NNS	denotes	variants
T13249	25586-25587	-LRB-	denotes	(
T13250	25587-25588	NN	denotes	G
T13251	25588-25589	SYM	denotes	-
T13252	25589-25590	NN	denotes	I
T13253	25590-25591	-RRB-	denotes	)
T13254	25592-25596	IN	denotes	from
T13255	25597-25605	NN	denotes	database
T13256	25606-25614	NN	denotes	analysis
T13257	25615-25618	CC	denotes	and
T13258	25619-25621	NN	denotes	rt
T13260	25621-25622	HYPH	denotes	-
T13259	25622-25625	NN	denotes	PCR
T13261	25626-25634	NN	denotes	analysis
T13262	25635-25637	IN	denotes	of
T13263	25638-25643	JJ	denotes	human
T13264	25644-25649	NN	denotes	brain
T13265	25650-25653	NN	denotes	RNA
T13266	25653-25654	.	denotes	.
T13267	25654-25709	sentence	denotes	(B): Alternative splicing of TACC1 in the human brain.
T13268	25655-25656	-LRB-	denotes	(
T13269	25656-25657	LS	denotes	B
T13271	25657-25658	-RRB-	denotes	)
T13272	25658-25660	:	denotes	:
T13273	25660-25671	JJ	denotes	Alternative
T13270	25672-25680	NN	denotes	splicing
T13274	25681-25683	IN	denotes	of
T13275	25684-25689	NN	denotes	TACC1
T13276	25690-25692	IN	denotes	in
T13277	25693-25696	DT	denotes	the
T13279	25697-25702	JJ	denotes	human
T13278	25703-25708	NN	denotes	brain
T13280	25708-25709	.	denotes	.
T13281	25709-25884	sentence	denotes	rt-PCR analysis confirms splicing of the untranslated exon 1a to exon 1, with retention of the originally defined start methionine (GB:NP_006274) (Variant A*, lanes 1 and 3).
T13282	25710-25712	NN	denotes	rt
T13284	25712-25713	HYPH	denotes	-
T13283	25713-25716	NN	denotes	PCR
T13285	25717-25725	NN	denotes	analysis
T13286	25726-25734	VBZ	denotes	confirms
T13287	25735-25743	NN	denotes	splicing
T13288	25744-25746	IN	denotes	of
T13289	25747-25750	DT	denotes	the
T13291	25751-25763	JJ	denotes	untranslated
T13290	25764-25768	NN	denotes	exon
T13292	25769-25771	CD	denotes	1a
T13293	25772-25774	IN	denotes	to
T13294	25775-25779	NN	denotes	exon
T13295	25780-25781	CD	denotes	1
T13296	25781-25783	,	denotes	,
T13297	25783-25787	IN	denotes	with
T13298	25788-25797	NN	denotes	retention
T13299	25798-25800	IN	denotes	of
T13300	25801-25804	DT	denotes	the
T13302	25805-25815	RB	denotes	originally
T13303	25816-25823	VBN	denotes	defined
T13304	25824-25829	NN	denotes	start
T13301	25830-25840	NN	denotes	methionine
T13305	25841-25842	-LRB-	denotes	(
T13307	25842-25844	NN	denotes	GB
T13308	25844-25845	:	denotes	:
T13306	25845-25854	NN	denotes	NP_006274
T13309	25854-25855	-RRB-	denotes	)
T13310	25856-25857	-LRB-	denotes	(
T13312	25857-25864	NN	denotes	Variant
T13313	25865-25866	NN	denotes	A
T13314	25866-25867	SYM	denotes	*
T13315	25867-25869	,	denotes	,
T13316	25869-25874	NNS	denotes	lanes
T13311	25875-25876	CD	denotes	1
T13317	25877-25880	CC	denotes	and
T13318	25881-25882	CD	denotes	3
T13319	25882-25883	-RRB-	denotes	)
T13320	25883-25884	.	denotes	.
T13321	25884-25981	sentence	denotes	Exon 1a also splices to exon 2, removing the L-Sm7 binding motif (variant I, lanes 3,12 and 13).
T13322	25885-25889	NN	denotes	Exon
T13324	25890-25892	CD	denotes	1a
T13325	25893-25897	RB	denotes	also
T13323	25898-25905	VBZ	denotes	splices
T13326	25906-25908	IN	denotes	to
T13327	25909-25913	NN	denotes	exon
T13328	25914-25915	CD	denotes	2
T13329	25915-25917	,	denotes	,
T13330	25917-25925	VBG	denotes	removing
T13331	25926-25929	DT	denotes	the
T13333	25930-25931	NN	denotes	L
T13335	25931-25932	HYPH	denotes	-
T13334	25932-25935	NN	denotes	Sm7
T13336	25936-25943	NN	denotes	binding
T13332	25944-25949	NN	denotes	motif
T13337	25950-25951	-LRB-	denotes	(
T13339	25951-25958	NN	denotes	variant
T13340	25959-25960	NN	denotes	I
T13341	25960-25962	,	denotes	,
T13342	25962-25967	NNS	denotes	lanes
T13338	25968-25969	CD	denotes	3
T13343	25969-25970	,	denotes	,
T13344	25970-25972	CD	denotes	12
T13345	25973-25976	CC	denotes	and
T13346	25977-25979	CD	denotes	13
T13347	25979-25980	-RRB-	denotes	)
T13348	25980-25981	.	denotes	.
T13349	25981-26167	sentence	denotes	Variants that functionally delete exons 2 and/or 3, such as variant C (lane 15) also remove the predicted nuclear localization signals, and the binding domains for GAS41 and PCTAIRE2BP.
T13350	25982-25990	NNS	denotes	Variants
T13352	25991-25995	WDT	denotes	that
T13354	25996-26008	RB	denotes	functionally
T13353	26009-26015	VBP	denotes	delete
T13355	26016-26021	NNS	denotes	exons
T13356	26022-26023	CD	denotes	2
T13357	26024-26027	CC	denotes	and
T13358	26027-26028	HYPH	denotes	/
T13359	26028-26030	CC	denotes	or
T13360	26031-26032	CD	denotes	3
T13361	26032-26034	,	denotes	,
T13362	26034-26038	JJ	denotes	such
T13363	26039-26041	IN	denotes	as
T13364	26042-26049	NN	denotes	variant
T13365	26050-26051	NN	denotes	C
T13366	26052-26053	-LRB-	denotes	(
T13367	26053-26057	NN	denotes	lane
T13368	26058-26060	CD	denotes	15
T13369	26060-26061	-RRB-	denotes	)
T13370	26062-26066	RB	denotes	also
T13351	26067-26073	VBP	denotes	remove
T13371	26074-26077	DT	denotes	the
T13373	26078-26087	VBN	denotes	predicted
T13374	26088-26095	JJ	denotes	nuclear
T13375	26096-26108	NN	denotes	localization
T13372	26109-26116	NNS	denotes	signals
T13376	26116-26118	,	denotes	,
T13377	26118-26121	CC	denotes	and
T13378	26122-26125	DT	denotes	the
T13380	26126-26133	NN	denotes	binding
T13379	26134-26141	NNS	denotes	domains
T13381	26142-26145	IN	denotes	for
T13382	26146-26151	NN	denotes	GAS41
T13383	26152-26155	CC	denotes	and
T13384	26156-26166	NN	denotes	PCTAIRE2BP
T13385	26166-26167	.	denotes	.
T13386	26167-26297	sentence	denotes	These variants would retain the TACC domain, and therefore the potential to bind to ch-TOG and Aurora A kinase in the centrosome.
T13387	26168-26173	DT	denotes	These
T13388	26174-26182	NNS	denotes	variants
T13390	26183-26188	MD	denotes	would
T13389	26189-26195	VB	denotes	retain
T13391	26196-26199	DT	denotes	the
T13393	26200-26204	NN	denotes	TACC
T13392	26205-26211	NN	denotes	domain
T13394	26211-26213	,	denotes	,
T13395	26213-26216	CC	denotes	and
T13396	26217-26226	RB	denotes	therefore
T13398	26227-26230	DT	denotes	the
T13397	26231-26240	NN	denotes	potential
T13399	26241-26243	TO	denotes	to
T13400	26244-26248	VB	denotes	bind
T13401	26249-26251	IN	denotes	to
T13402	26252-26254	NN	denotes	ch
T13404	26254-26255	HYPH	denotes	-
T13403	26255-26258	NN	denotes	TOG
T13405	26259-26262	CC	denotes	and
T13406	26263-26269	NN	denotes	Aurora
T13407	26270-26271	NN	denotes	A
T13408	26272-26278	NN	denotes	kinase
T13409	26279-26281	IN	denotes	in
T13410	26282-26285	DT	denotes	the
T13411	26286-26296	NN	denotes	centrosome
T13412	26296-26297	.	denotes	.
T13413	26297-26602	sentence	denotes	Lane 1: EF/X1R, Lane 2: EF/BX647R, Lane 3: EF/6SPR, Lane 4: EF/1DR, Lane 5, EF/128R, Lane 6 X3F/X1R, Lane 7: X3F/BX647R, Lane 8: X3F/6SPR, Lane 9: X3F/1DR, Lane 10, X3F/128R, Lane 11: 1DF/X1R, Lane 12: 1DF/BX647R, Lane 13: 1DF/6SPR, Lane 14: 1DF/1DR, Lane 15: 1DF/128R, Lane 16: Biorad 1 kb+ Size ladder.
T13414	26298-26302	NN	denotes	Lane
T13416	26303-26304	CD	denotes	1
T13417	26304-26306	:	denotes	:
T13418	26306-26308	NN	denotes	EF
T13419	26308-26309	HYPH	denotes	/
T13415	26309-26312	NN	denotes	X1R
T13421	26312-26314	,	denotes	,
T13422	26314-26318	NN	denotes	Lane
T13424	26319-26320	CD	denotes	2
T13425	26320-26322	:	denotes	:
T13426	26322-26324	NN	denotes	EF
T13427	26324-26325	HYPH	denotes	/
T13423	26325-26331	NN	denotes	BX647R
T13428	26331-26333	,	denotes	,
T13429	26333-26337	NN	denotes	Lane
T13431	26338-26339	CD	denotes	3
T13432	26339-26341	:	denotes	:
T13433	26341-26343	NN	denotes	EF
T13434	26343-26344	HYPH	denotes	/
T13430	26344-26348	NN	denotes	6SPR
T13435	26348-26350	,	denotes	,
T13436	26350-26354	NN	denotes	Lane
T13438	26355-26356	CD	denotes	4
T13439	26356-26358	:	denotes	:
T13440	26358-26360	NN	denotes	EF
T13441	26360-26361	HYPH	denotes	/
T13437	26361-26364	NN	denotes	1DR
T13442	26364-26366	,	denotes	,
T13443	26366-26370	NN	denotes	Lane
T13445	26371-26372	CD	denotes	5
T13446	26372-26374	,	denotes	,
T13447	26374-26376	NN	denotes	EF
T13448	26376-26377	HYPH	denotes	/
T13444	26377-26381	NN	denotes	128R
T13449	26381-26383	,	denotes	,
T13450	26383-26387	NN	denotes	Lane
T13452	26388-26389	CD	denotes	6
T13453	26390-26393	NN	denotes	X3F
T13454	26393-26394	HYPH	denotes	/
T13451	26394-26397	NN	denotes	X1R
T13455	26397-26399	,	denotes	,
T13456	26399-26403	NN	denotes	Lane
T13458	26404-26405	CD	denotes	7
T13459	26405-26407	:	denotes	:
T13460	26407-26410	NN	denotes	X3F
T13461	26410-26411	HYPH	denotes	/
T13457	26411-26417	NN	denotes	BX647R
T13462	26417-26419	,	denotes	,
T13463	26419-26423	NN	denotes	Lane
T13465	26424-26425	CD	denotes	8
T13466	26425-26427	:	denotes	:
T13467	26427-26430	NN	denotes	X3F
T13468	26430-26431	HYPH	denotes	/
T13464	26431-26435	NN	denotes	6SPR
T13469	26435-26437	,	denotes	,
T13470	26437-26441	NN	denotes	Lane
T13472	26442-26443	CD	denotes	9
T13473	26443-26445	:	denotes	:
T13474	26445-26448	NN	denotes	X3F
T13475	26448-26449	HYPH	denotes	/
T13471	26449-26452	NN	denotes	1DR
T13476	26452-26454	,	denotes	,
T13477	26454-26458	NN	denotes	Lane
T13479	26459-26461	CD	denotes	10
T13480	26461-26463	,	denotes	,
T13481	26463-26466	NN	denotes	X3F
T13482	26466-26467	HYPH	denotes	/
T13478	26467-26471	NN	denotes	128R
T13483	26471-26473	,	denotes	,
T13484	26473-26477	NN	denotes	Lane
T13486	26478-26480	CD	denotes	11
T13487	26480-26482	:	denotes	:
T13488	26482-26485	NN	denotes	1DF
T13489	26485-26486	HYPH	denotes	/
T13485	26486-26489	NN	denotes	X1R
T13490	26489-26491	,	denotes	,
T13491	26491-26495	NN	denotes	Lane
T13493	26496-26498	CD	denotes	12
T13494	26498-26500	:	denotes	:
T13495	26500-26503	NN	denotes	1DF
T13496	26503-26504	HYPH	denotes	/
T13492	26504-26510	NN	denotes	BX647R
T13497	26510-26512	,	denotes	,
T13498	26512-26516	NN	denotes	Lane
T13500	26517-26519	CD	denotes	13
T13501	26519-26521	:	denotes	:
T13502	26521-26524	NN	denotes	1DF
T13503	26524-26525	HYPH	denotes	/
T13499	26525-26529	NN	denotes	6SPR
T13504	26529-26531	,	denotes	,
T13505	26531-26535	NN	denotes	Lane
T13507	26536-26538	CD	denotes	14
T13508	26538-26540	:	denotes	:
T13509	26540-26543	NN	denotes	1DF
T13510	26543-26544	HYPH	denotes	/
T13506	26544-26547	NN	denotes	1DR
T13511	26547-26549	,	denotes	,
T13512	26549-26553	NN	denotes	Lane
T13514	26554-26556	CD	denotes	15
T13515	26556-26558	:	denotes	:
T13516	26558-26561	NN	denotes	1DF
T13517	26561-26562	HYPH	denotes	/
T13513	26562-26566	NN	denotes	128R
T13518	26566-26568	,	denotes	,
T13519	26568-26572	NN	denotes	Lane
T13520	26573-26575	CD	denotes	16
T13521	26575-26577	:	denotes	:
T13522	26577-26583	NNP	denotes	Biorad
T13523	26584-26585	CD	denotes	1
T13524	26586-26589	NN	denotes	kb+
T13525	26590-26594	NN	denotes	Size
T13420	26595-26601	NN	denotes	ladder
T13526	26601-26602	.	denotes	.
T7167	26604-26606	FW	denotes	In
T7168	26607-26613	FW	denotes	silico
T7169	26614-26622	NN	denotes	modeling
T7170	26623-26625	IN	denotes	of
T7171	26626-26629	DT	denotes	the
T7172	26630-26639	NN	denotes	evolution
T7173	26640-26642	IN	denotes	of
T7174	26643-26647	NN	denotes	TACC
T7175	26648-26655	NN	denotes	protein
T7176	26656-26664	NN	denotes	function
T7177	26664-26869	sentence	denotes	The protein and genomic structure of the present day TACC family members suggests that the function of the ancestral TACC protein was mediated solely through the interactions of the conserved TACC domain.
T7178	26665-26668	DT	denotes	The
T7180	26669-26676	NN	denotes	protein
T7181	26677-26680	CC	denotes	and
T7182	26681-26688	JJ	denotes	genomic
T7179	26689-26698	NN	denotes	structure
T7184	26699-26701	IN	denotes	of
T7185	26702-26705	DT	denotes	the
T7187	26706-26713	JJ	denotes	present
T7188	26714-26717	NN	denotes	day
T7189	26718-26722	NN	denotes	TACC
T7190	26723-26729	NN	denotes	family
T7186	26730-26737	NNS	denotes	members
T7183	26738-26746	VBZ	denotes	suggests
T7191	26747-26751	IN	denotes	that
T7193	26752-26755	DT	denotes	the
T7194	26756-26764	NN	denotes	function
T7195	26765-26767	IN	denotes	of
T7196	26768-26771	DT	denotes	the
T7198	26772-26781	JJ	denotes	ancestral
T7199	26782-26786	NN	denotes	TACC
T7197	26787-26794	NN	denotes	protein
T7200	26795-26798	VBD	denotes	was
T7192	26799-26807	VBN	denotes	mediated
T7201	26808-26814	RB	denotes	solely
T7202	26815-26822	IN	denotes	through
T7203	26823-26826	DT	denotes	the
T7204	26827-26839	NNS	denotes	interactions
T7205	26840-26842	IN	denotes	of
T7206	26843-26846	DT	denotes	the
T7208	26847-26856	VBN	denotes	conserved
T7209	26857-26861	NN	denotes	TACC
T7207	26862-26868	NN	denotes	domain
T7210	26868-26869	.	denotes	.
T7211	26869-27168	sentence	denotes	Using an in silico protein-protein interaction model based upon known mitotic spindle and centrosomal components, we have previously predicted a number of additional interactions that could be conserved between a functional TACC homologue in yeast, spc-72, and one or more human TACC proteins [21].
T7212	26870-26875	VBG	denotes	Using
T7214	26876-26878	DT	denotes	an
T7216	26879-26881	FW	denotes	in
T7217	26882-26888	FW	denotes	silico
T7218	26889-26896	NN	denotes	protein
T7220	26896-26897	HYPH	denotes	-
T7219	26897-26904	NN	denotes	protein
T7221	26905-26916	NN	denotes	interaction
T7215	26917-26922	NN	denotes	model
T7222	26923-26928	VBN	denotes	based
T7223	26929-26933	IN	denotes	upon
T7224	26934-26939	JJ	denotes	known
T7226	26940-26947	JJ	denotes	mitotic
T7227	26948-26955	NN	denotes	spindle
T7228	26956-26959	CC	denotes	and
T7229	26960-26971	JJ	denotes	centrosomal
T7225	26972-26982	NNS	denotes	components
T7230	26982-26984	,	denotes	,
T7231	26984-26986	PRP	denotes	we
T7232	26987-26991	VBP	denotes	have
T7233	26992-27002	RB	denotes	previously
T7213	27003-27012	VBN	denotes	predicted
T7234	27013-27014	DT	denotes	a
T7235	27015-27021	NN	denotes	number
T7236	27022-27024	IN	denotes	of
T7237	27025-27035	JJ	denotes	additional
T7238	27036-27048	NNS	denotes	interactions
T7239	27049-27053	WDT	denotes	that
T7241	27054-27059	MD	denotes	could
T7242	27060-27062	VB	denotes	be
T7240	27063-27072	VBN	denotes	conserved
T7243	27073-27080	IN	denotes	between
T7244	27081-27082	DT	denotes	a
T7246	27083-27093	JJ	denotes	functional
T7247	27094-27098	NN	denotes	TACC
T7245	27099-27108	NN	denotes	homologue
T7248	27109-27111	IN	denotes	in
T7249	27112-27117	NN	denotes	yeast
T7250	27117-27119	,	denotes	,
T7251	27119-27122	NN	denotes	spc
T7252	27122-27123	HYPH	denotes	-
T7253	27123-27125	CD	denotes	72
T7254	27125-27127	,	denotes	,
T7255	27127-27130	CC	denotes	and
T7256	27131-27134	CD	denotes	one
T7258	27135-27137	CC	denotes	or
T7259	27138-27142	JJR	denotes	more
T7260	27143-27148	JJ	denotes	human
T7261	27149-27153	NN	denotes	TACC
T7257	27154-27162	NN	denotes	proteins
T7262	27163-27164	-LRB-	denotes	[
T7263	27164-27166	CD	denotes	21
T7264	27166-27167	-RRB-	denotes	]
T7265	27167-27168	.	denotes	.
T7266	27168-27387	sentence	denotes	Thus, it is known that all the TACC proteins examined to date interact, via the TACC domain, with the microtubule/centrosomal proteins of the stu2/msps/ch-TOG family [5,6,22-24], and with the Aurora kinases [20,21,25].
T7267	27169-27173	RB	denotes	Thus
T7269	27173-27175	,	denotes	,
T7270	27175-27177	PRP	denotes	it
T7271	27178-27180	VBZ	denotes	is
T7268	27181-27186	VBN	denotes	known
T7272	27187-27191	IN	denotes	that
T7274	27192-27195	PDT	denotes	all
T7276	27196-27199	DT	denotes	the
T7277	27200-27204	NN	denotes	TACC
T7275	27205-27213	NN	denotes	proteins
T7278	27214-27222	VBN	denotes	examined
T7279	27223-27225	IN	denotes	to
T7280	27226-27230	NN	denotes	date
T7273	27231-27239	VBP	denotes	interact
T7281	27239-27241	,	denotes	,
T7282	27241-27244	IN	denotes	via
T7283	27245-27248	DT	denotes	the
T7285	27249-27253	NN	denotes	TACC
T7284	27254-27260	NN	denotes	domain
T7286	27260-27262	,	denotes	,
T7287	27262-27266	IN	denotes	with
T7288	27267-27270	DT	denotes	the
T7290	27271-27282	NN	denotes	microtubule
T7292	27282-27283	HYPH	denotes	/
T7291	27283-27294	JJ	denotes	centrosomal
T7289	27295-27303	NN	denotes	proteins
T7293	27304-27306	IN	denotes	of
T7294	27307-27310	DT	denotes	the
T7296	27311-27315	NN	denotes	stu2
T7297	27315-27316	HYPH	denotes	/
T7298	27316-27320	NN	denotes	msps
T7299	27320-27321	HYPH	denotes	/
T7300	27321-27323	NN	denotes	ch
T7302	27323-27324	HYPH	denotes	-
T7301	27324-27327	NN	denotes	TOG
T7295	27328-27334	NN	denotes	family
T7303	27335-27336	-LRB-	denotes	[
T7304	27336-27337	CD	denotes	5
T7305	27337-27338	,	denotes	,
T7306	27338-27339	CD	denotes	6
T7307	27339-27340	,	denotes	,
T7308	27340-27342	CD	denotes	22
T7309	27342-27343	SYM	denotes	-
T7310	27343-27345	CD	denotes	24
T7311	27345-27346	-RRB-	denotes	]
T7312	27346-27348	,	denotes	,
T7313	27348-27351	CC	denotes	and
T7314	27352-27356	IN	denotes	with
T7315	27357-27360	DT	denotes	the
T7317	27361-27367	NN	denotes	Aurora
T7316	27368-27375	NNS	denotes	kinases
T7318	27376-27377	-LRB-	denotes	[
T7320	27377-27379	CD	denotes	20
T7321	27379-27380	,	denotes	,
T7322	27380-27382	CD	denotes	21
T7323	27382-27383	,	denotes	,
T7319	27383-27385	CD	denotes	25
T7324	27385-27386	-RRB-	denotes	]
T7325	27386-27387	.	denotes	.
T7326	27387-27519	sentence	denotes	These interactions are required for the accumulation of the D-TACC, spc72, ceTAC1 and TACC3 proteins to the centrosome [5,6,22-24].
T7327	27388-27393	DT	denotes	These
T7328	27394-27406	NNS	denotes	interactions
T7330	27407-27410	VBP	denotes	are
T7329	27411-27419	VBN	denotes	required
T7331	27420-27423	IN	denotes	for
T7332	27424-27427	DT	denotes	the
T7333	27428-27440	NN	denotes	accumulation
T7334	27441-27443	IN	denotes	of
T7335	27444-27447	DT	denotes	the
T7337	27448-27449	NN	denotes	D
T7339	27449-27450	HYPH	denotes	-
T7338	27450-27454	NN	denotes	TACC
T7340	27454-27456	,	denotes	,
T7341	27456-27461	NN	denotes	spc72
T7342	27461-27463	,	denotes	,
T7343	27463-27469	NN	denotes	ceTAC1
T7344	27470-27473	CC	denotes	and
T7345	27474-27479	NN	denotes	TACC3
T7336	27480-27488	NN	denotes	proteins
T7346	27489-27491	IN	denotes	to
T7347	27492-27495	DT	denotes	the
T7348	27496-27506	NN	denotes	centrosome
T7349	27507-27508	-LRB-	denotes	[
T7350	27508-27509	CD	denotes	5
T7351	27509-27510	,	denotes	,
T7352	27510-27511	CD	denotes	6
T7353	27511-27512	,	denotes	,
T7354	27512-27514	CD	denotes	22
T7355	27514-27515	SYM	denotes	-
T7356	27515-27517	CD	denotes	24
T7357	27517-27518	-RRB-	denotes	]
T7358	27518-27519	.	denotes	.
T7359	27519-27669	sentence	denotes	Hence, this functional interaction with the centrosome and mitotic spindle is likely to represent the ancient, conserved function of the TACC family.
T7360	27520-27525	RB	denotes	Hence
T7362	27525-27527	,	denotes	,
T7363	27527-27531	DT	denotes	this
T7365	27532-27542	JJ	denotes	functional
T7364	27543-27554	NN	denotes	interaction
T7366	27555-27559	IN	denotes	with
T7367	27560-27563	DT	denotes	the
T7368	27564-27574	NN	denotes	centrosome
T7369	27575-27578	CC	denotes	and
T7370	27579-27586	JJ	denotes	mitotic
T7371	27587-27594	NN	denotes	spindle
T7361	27595-27597	VBZ	denotes	is
T7372	27598-27604	JJ	denotes	likely
T7373	27605-27607	TO	denotes	to
T7374	27608-27617	VB	denotes	represent
T7375	27618-27621	DT	denotes	the
T7377	27622-27629	JJ	denotes	ancient
T7378	27629-27631	,	denotes	,
T7379	27631-27640	VBN	denotes	conserved
T7376	27641-27649	NN	denotes	function
T7380	27650-27652	IN	denotes	of
T7381	27653-27656	DT	denotes	the
T7383	27657-27661	NN	denotes	TACC
T7382	27662-27668	NN	denotes	family
T7384	27668-27669	.	denotes	.
T7385	27669-27788	sentence	denotes	However, it is apparent that the human TACC proteins also differ in their ability to interact with the Aurora kinases.
T7386	27670-27677	RB	denotes	However
T7388	27677-27679	,	denotes	,
T7389	27679-27681	PRP	denotes	it
T7387	27682-27684	VBZ	denotes	is
T7390	27685-27693	JJ	denotes	apparent
T7391	27694-27698	IN	denotes	that
T7393	27699-27702	DT	denotes	the
T7395	27703-27708	JJ	denotes	human
T7396	27709-27713	NN	denotes	TACC
T7394	27714-27722	NN	denotes	proteins
T7397	27723-27727	RB	denotes	also
T7392	27728-27734	VBP	denotes	differ
T7398	27735-27737	IN	denotes	in
T7399	27738-27743	PRP$	denotes	their
T7400	27744-27751	NN	denotes	ability
T7401	27752-27754	TO	denotes	to
T7402	27755-27763	VB	denotes	interact
T7403	27764-27768	IN	denotes	with
T7404	27769-27772	DT	denotes	the
T7406	27773-27779	NN	denotes	Aurora
T7405	27780-27787	NNS	denotes	kinases
T7407	27787-27788	.	denotes	.
T7408	27788-28050	sentence	denotes	For instance, TACC1 and TACC3 interact with Aurora A kinase, whereas TACC2 interacts with Aurora C kinase [21], suggesting a degree of functional specialization in the derivatives of the ancestral chordate TACC, after the radiation of the vertebrate TACC genes.
T7409	27789-27792	IN	denotes	For
T7411	27793-27801	NN	denotes	instance
T7412	27801-27803	,	denotes	,
T7413	27803-27808	NN	denotes	TACC1
T7414	27809-27812	CC	denotes	and
T7415	27813-27818	NN	denotes	TACC3
T7410	27819-27827	VBP	denotes	interact
T7416	27828-27832	IN	denotes	with
T7417	27833-27839	NN	denotes	Aurora
T7418	27840-27841	NN	denotes	A
T7419	27842-27848	NN	denotes	kinase
T7420	27848-27850	,	denotes	,
T7421	27850-27857	IN	denotes	whereas
T7423	27858-27863	NN	denotes	TACC2
T7422	27864-27873	VBZ	denotes	interacts
T7424	27874-27878	IN	denotes	with
T7425	27879-27885	NN	denotes	Aurora
T7426	27886-27887	NN	denotes	C
T7427	27888-27894	NN	denotes	kinase
T7428	27895-27896	-LRB-	denotes	[
T7429	27896-27898	CD	denotes	21
T7430	27898-27899	-RRB-	denotes	]
T7431	27899-27901	,	denotes	,
T7432	27901-27911	VBG	denotes	suggesting
T7433	27912-27913	DT	denotes	a
T7434	27914-27920	NN	denotes	degree
T7435	27921-27923	IN	denotes	of
T7436	27924-27934	JJ	denotes	functional
T7437	27935-27949	NN	denotes	specialization
T7438	27950-27952	IN	denotes	in
T7439	27953-27956	DT	denotes	the
T7440	27957-27968	NNS	denotes	derivatives
T7441	27969-27971	IN	denotes	of
T7442	27972-27975	DT	denotes	the
T7444	27976-27985	JJ	denotes	ancestral
T7445	27986-27994	NN	denotes	chordate
T7443	27995-27999	NN	denotes	TACC
T7446	27999-28001	,	denotes	,
T7447	28001-28006	IN	denotes	after
T7448	28007-28010	DT	denotes	the
T7449	28011-28020	NN	denotes	radiation
T7450	28021-28023	IN	denotes	of
T7451	28024-28027	DT	denotes	the
T7453	28028-28038	NN	denotes	vertebrate
T7454	28039-28043	NN	denotes	TACC
T7452	28044-28049	NNS	denotes	genes
T7455	28049-28050	.	denotes	.
T7456	28050-28252	sentence	denotes	The localization of the vertebrate TACC proteins in the interphase nucleus [15,26,27] suggests that they have additional functions outside their ancient role in the centrosome and microtubule dynamics.
T7457	28051-28054	DT	denotes	The
T7458	28055-28067	NN	denotes	localization
T7460	28068-28070	IN	denotes	of
T7461	28071-28074	DT	denotes	the
T7463	28075-28085	NN	denotes	vertebrate
T7464	28086-28090	NN	denotes	TACC
T7462	28091-28099	NN	denotes	proteins
T7465	28100-28102	IN	denotes	in
T7466	28103-28106	DT	denotes	the
T7468	28107-28117	NN	denotes	interphase
T7467	28118-28125	NN	denotes	nucleus
T7469	28126-28127	-LRB-	denotes	[
T7471	28127-28129	CD	denotes	15
T7472	28129-28130	,	denotes	,
T7473	28130-28132	CD	denotes	26
T7474	28132-28133	,	denotes	,
T7470	28133-28135	CD	denotes	27
T7475	28135-28136	-RRB-	denotes	]
T7459	28137-28145	VBZ	denotes	suggests
T7476	28146-28150	IN	denotes	that
T7478	28151-28155	PRP	denotes	they
T7477	28156-28160	VBP	denotes	have
T7479	28161-28171	JJ	denotes	additional
T7480	28172-28181	NNS	denotes	functions
T7481	28182-28189	IN	denotes	outside
T7482	28190-28195	PRP$	denotes	their
T7484	28196-28203	JJ	denotes	ancient
T7483	28204-28208	NN	denotes	role
T7485	28209-28211	IN	denotes	in
T7486	28212-28215	DT	denotes	the
T7488	28216-28226	NN	denotes	centrosome
T7489	28227-28230	CC	denotes	and
T7490	28231-28242	NN	denotes	microtubule
T7487	28243-28251	NNS	denotes	dynamics
T7491	28251-28252	.	denotes	.
T7492	28252-28423	sentence	denotes	Thus, it seems likely that TACC family members in protostomes and deuterostomes have integrated new unique functions as the evolving TACC genes acquired additional exons.
T7493	28253-28257	RB	denotes	Thus
T7495	28257-28259	,	denotes	,
T7496	28259-28261	PRP	denotes	it
T7494	28262-28267	VBZ	denotes	seems
T7497	28268-28274	JJ	denotes	likely
T7498	28275-28279	IN	denotes	that
T7500	28280-28284	NN	denotes	TACC
T7502	28285-28291	NN	denotes	family
T7501	28292-28299	NNS	denotes	members
T7503	28300-28302	IN	denotes	in
T7504	28303-28314	NNS	denotes	protostomes
T7505	28315-28318	CC	denotes	and
T7506	28319-28332	NNS	denotes	deuterostomes
T7507	28333-28337	VBP	denotes	have
T7499	28338-28348	VBN	denotes	integrated
T7508	28349-28352	JJ	denotes	new
T7510	28353-28359	JJ	denotes	unique
T7509	28360-28369	NNS	denotes	functions
T7511	28370-28372	IN	denotes	as
T7513	28373-28376	DT	denotes	the
T7515	28377-28385	VBG	denotes	evolving
T7516	28386-28390	NN	denotes	TACC
T7514	28391-28396	NNS	denotes	genes
T7512	28397-28405	VBD	denotes	acquired
T7517	28406-28416	JJ	denotes	additional
T7518	28417-28422	NNS	denotes	exons
T7519	28422-28423	.	denotes	.
T7520	28423-28579	sentence	denotes	The results of the pilot large-scale proteomic analysis in C. elegans and D. melanogaster provide further suggestive evidence to this functional evolution.
T7521	28424-28427	DT	denotes	The
T7522	28428-28435	NNS	denotes	results
T7524	28436-28438	IN	denotes	of
T7525	28439-28442	DT	denotes	the
T7527	28443-28448	NN	denotes	pilot
T7528	28449-28454	JJ	denotes	large
T7530	28454-28455	HYPH	denotes	-
T7529	28455-28460	NN	denotes	scale
T7531	28461-28470	JJ	denotes	proteomic
T7526	28471-28479	NN	denotes	analysis
T7532	28480-28482	IN	denotes	in
T7533	28483-28485	NNP	denotes	C.
T7534	28486-28493	NNP	denotes	elegans
T7535	28494-28497	CC	denotes	and
T7536	28498-28500	NNP	denotes	D.
T7537	28501-28513	NNP	denotes	melanogaster
T7523	28514-28521	VBP	denotes	provide
T7538	28522-28529	JJ	denotes	further
T7540	28530-28540	JJ	denotes	suggestive
T7539	28541-28549	NN	denotes	evidence
T7541	28550-28552	IN	denotes	to
T7542	28553-28557	DT	denotes	this
T7544	28558-28568	JJ	denotes	functional
T7543	28569-28578	NN	denotes	evolution
T7545	28578-28579	.	denotes	.
T7546	28579-28685	sentence	denotes	Yeast two hybrid analysis indicates that ceTAC directly binds to C. elegans lin15A, lin36 and lin37 [28].
T7547	28580-28585	NN	denotes	Yeast
T7549	28586-28589	CD	denotes	two
T7550	28590-28596	NN	denotes	hybrid
T7548	28597-28605	NN	denotes	analysis
T7551	28606-28615	VBZ	denotes	indicates
T7552	28616-28620	IN	denotes	that
T7554	28621-28626	NN	denotes	ceTAC
T7555	28627-28635	RB	denotes	directly
T7553	28636-28641	VBZ	denotes	binds
T7556	28642-28644	IN	denotes	to
T7557	28645-28647	NNP	denotes	C.
T7559	28648-28655	NNP	denotes	elegans
T7558	28656-28662	NN	denotes	lin15A
T7560	28662-28664	,	denotes	,
T7561	28664-28669	NN	denotes	lin36
T7562	28670-28673	CC	denotes	and
T7563	28674-28679	NN	denotes	lin37
T7564	28680-28681	-LRB-	denotes	[
T7565	28681-28683	CD	denotes	28
T7566	28683-28684	-RRB-	denotes	]
T7567	28684-28685	.	denotes	.
T7568	28685-29068	sentence	denotes	These proteins bridge ceTAC to other elements of the cytoskeleton and microtubule network, as well as to components of the ribosome, the histone deacetylase chromatin remodeling machinery such as egr-1 and lin-53 (the C. elegans homologues of the human MTA-1 and RbAP48), and to transcription factors such as the PAL1 homeobox and the nuclear hormone receptor nhr-86 [28] (Fig. 6A).
T7569	28686-28691	DT	denotes	These
T7570	28692-28700	NN	denotes	proteins
T7571	28701-28707	VBP	denotes	bridge
T7572	28708-28713	NN	denotes	ceTAC
T7573	28714-28716	IN	denotes	to
T7574	28717-28722	JJ	denotes	other
T7575	28723-28731	NNS	denotes	elements
T7576	28732-28734	IN	denotes	of
T7577	28735-28738	DT	denotes	the
T7579	28739-28751	NN	denotes	cytoskeleton
T7580	28752-28755	CC	denotes	and
T7581	28756-28767	NN	denotes	microtubule
T7578	28768-28775	NN	denotes	network
T7582	28775-28777	,	denotes	,
T7583	28777-28779	RB	denotes	as
T7585	28780-28784	RB	denotes	well
T7584	28785-28787	IN	denotes	as
T7586	28788-28790	IN	denotes	to
T7587	28791-28801	NNS	denotes	components
T7588	28802-28804	IN	denotes	of
T7589	28805-28808	DT	denotes	the
T7590	28809-28817	NN	denotes	ribosome
T7591	28817-28819	,	denotes	,
T7592	28819-28822	DT	denotes	the
T7594	28823-28830	NN	denotes	histone
T7595	28831-28842	NN	denotes	deacetylase
T7596	28843-28852	NN	denotes	chromatin
T7597	28853-28863	VBG	denotes	remodeling
T7593	28864-28873	NN	denotes	machinery
T7598	28874-28878	JJ	denotes	such
T7599	28879-28881	IN	denotes	as
T7600	28882-28885	NN	denotes	egr
T7601	28885-28886	HYPH	denotes	-
T7602	28886-28887	CD	denotes	1
T7603	28888-28891	CC	denotes	and
T7604	28892-28895	NN	denotes	lin
T7605	28895-28896	HYPH	denotes	-
T7606	28896-28898	CD	denotes	53
T7607	28899-28900	-LRB-	denotes	(
T7608	28900-28903	DT	denotes	the
T7610	28904-28906	NNP	denotes	C.
T7611	28907-28914	NNP	denotes	elegans
T7609	28915-28925	NNS	denotes	homologues
T7612	28926-28928	IN	denotes	of
T7613	28929-28932	DT	denotes	the
T7615	28933-28938	JJ	denotes	human
T7614	28939-28942	NN	denotes	MTA
T7616	28942-28943	HYPH	denotes	-
T7617	28943-28944	CD	denotes	1
T7618	28945-28948	CC	denotes	and
T7619	28949-28955	NN	denotes	RbAP48
T7620	28955-28956	-RRB-	denotes	)
T7621	28956-28958	,	denotes	,
T7622	28958-28961	CC	denotes	and
T7623	28962-28964	IN	denotes	to
T7624	28965-28978	NN	denotes	transcription
T7625	28979-28986	NNS	denotes	factors
T7626	28987-28991	JJ	denotes	such
T7627	28992-28994	IN	denotes	as
T7628	28995-28998	DT	denotes	the
T7630	28999-29003	NN	denotes	PAL1
T7629	29004-29012	NN	denotes	homeobox
T7631	29013-29016	CC	denotes	and
T7632	29017-29020	DT	denotes	the
T7634	29021-29028	JJ	denotes	nuclear
T7635	29029-29036	NN	denotes	hormone
T7633	29037-29045	NN	denotes	receptor
T7636	29046-29049	NN	denotes	nhr
T7637	29049-29050	HYPH	denotes	-
T7638	29050-29052	CD	denotes	86
T7639	29053-29054	-LRB-	denotes	[
T7640	29054-29056	CD	denotes	28
T7641	29056-29057	-RRB-	denotes	]
T7642	29058-29059	-LRB-	denotes	(
T7643	29059-29063	NN	denotes	Fig.
T7644	29064-29066	CD	denotes	6A
T7645	29066-29067	-RRB-	denotes	)
T7646	29067-29068	.	denotes	.
T7647	29068-29329	sentence	denotes	Similarly, large scale proteomics [29] has shown that Drosophila TACC interacts with two proteins, the RNA binding protein TBPH and CG14540 (Fig. 6B), and thus indirectly with the Drosophila SWI/SNF chromatin remodeling complex and DNA damage repair machinery.
T7648	29069-29078	RB	denotes	Similarly
T7650	29078-29080	,	denotes	,
T7651	29080-29085	JJ	denotes	large
T7652	29086-29091	NN	denotes	scale
T7653	29092-29102	NNS	denotes	proteomics
T7654	29103-29104	-LRB-	denotes	[
T7655	29104-29106	CD	denotes	29
T7656	29106-29107	-RRB-	denotes	]
T7657	29108-29111	VBZ	denotes	has
T7649	29112-29117	VBN	denotes	shown
T7658	29118-29122	IN	denotes	that
T7660	29123-29133	NNP	denotes	Drosophila
T7661	29134-29138	NN	denotes	TACC
T7659	29139-29148	VBZ	denotes	interacts
T7662	29149-29153	IN	denotes	with
T7663	29154-29157	CD	denotes	two
T7664	29158-29166	NN	denotes	proteins
T7665	29166-29168	,	denotes	,
T7666	29168-29171	DT	denotes	the
T7668	29172-29175	NN	denotes	RNA
T7669	29176-29183	NN	denotes	binding
T7667	29184-29191	NN	denotes	protein
T7670	29192-29196	NN	denotes	TBPH
T7671	29197-29200	CC	denotes	and
T7672	29201-29208	NN	denotes	CG14540
T7673	29209-29210	-LRB-	denotes	(
T7674	29210-29214	NN	denotes	Fig.
T7675	29215-29217	CD	denotes	6B
T7676	29217-29218	-RRB-	denotes	)
T7677	29218-29220	,	denotes	,
T7678	29220-29223	CC	denotes	and
T7679	29224-29228	RB	denotes	thus
T7681	29229-29239	RB	denotes	indirectly
T7680	29240-29244	IN	denotes	with
T7682	29245-29248	DT	denotes	the
T7684	29249-29259	NNP	denotes	Drosophila
T7685	29260-29263	NN	denotes	SWI
T7687	29263-29264	HYPH	denotes	/
T7686	29264-29267	NN	denotes	SNF
T7688	29268-29277	NN	denotes	chromatin
T7689	29278-29288	NN	denotes	remodeling
T7683	29289-29296	NN	denotes	complex
T7690	29297-29300	CC	denotes	and
T7691	29301-29304	NN	denotes	DNA
T7692	29305-29311	NN	denotes	damage
T7693	29312-29318	NN	denotes	repair
T7694	29319-29328	NN	denotes	machinery
T7695	29328-29329	.	denotes	.
T7696	29329-29484	sentence	denotes	Significantly, the ceTAC protein has also recently been implicated in DNA repair through its direct interaction with the C. elegans BARD1 orthologue [30].
T7697	29330-29343	RB	denotes	Significantly
T7699	29343-29345	,	denotes	,
T7700	29345-29348	DT	denotes	the
T7702	29349-29354	NN	denotes	ceTAC
T7701	29355-29362	NN	denotes	protein
T7703	29363-29366	VBZ	denotes	has
T7704	29367-29371	RB	denotes	also
T7705	29372-29380	RB	denotes	recently
T7706	29381-29385	VBN	denotes	been
T7698	29386-29396	VBN	denotes	implicated
T7707	29397-29399	IN	denotes	in
T7708	29400-29403	NN	denotes	DNA
T7709	29404-29410	NN	denotes	repair
T7710	29411-29418	IN	denotes	through
T7711	29419-29422	PRP$	denotes	its
T7713	29423-29429	JJ	denotes	direct
T7712	29430-29441	NN	denotes	interaction
T7714	29442-29446	IN	denotes	with
T7715	29447-29450	DT	denotes	the
T7717	29451-29453	NNP	denotes	C.
T7718	29454-29461	NNP	denotes	elegans
T7719	29462-29467	NN	denotes	BARD1
T7716	29468-29478	NN	denotes	orthologue
T7720	29479-29480	-LRB-	denotes	[
T7721	29480-29482	CD	denotes	30
T7722	29482-29483	-RRB-	denotes	]
T7723	29483-29484	.	denotes	.
T7724	29484-29740	sentence	denotes	It should be noted that a number of interactions with the TACC proteins from these organisms have probably been missed by these large scale methods, including the well documented direct interactions with the aurora kinases and the stu2/msps/ch-TOG family.
T7725	29485-29487	PRP	denotes	It
T7727	29488-29494	MD	denotes	should
T7728	29495-29497	VB	denotes	be
T7726	29498-29503	VBN	denotes	noted
T7729	29504-29508	IN	denotes	that
T7731	29509-29510	DT	denotes	a
T7732	29511-29517	NN	denotes	number
T7733	29518-29520	IN	denotes	of
T7734	29521-29533	NNS	denotes	interactions
T7735	29534-29538	IN	denotes	with
T7736	29539-29542	DT	denotes	the
T7738	29543-29547	NN	denotes	TACC
T7737	29548-29556	NN	denotes	proteins
T7739	29557-29561	IN	denotes	from
T7740	29562-29567	DT	denotes	these
T7741	29568-29577	NNS	denotes	organisms
T7742	29578-29582	VBP	denotes	have
T7743	29583-29591	RB	denotes	probably
T7744	29592-29596	VBN	denotes	been
T7730	29597-29603	VBN	denotes	missed
T7745	29604-29606	IN	denotes	by
T7746	29607-29612	DT	denotes	these
T7748	29613-29618	JJ	denotes	large
T7749	29619-29624	NN	denotes	scale
T7747	29625-29632	NNS	denotes	methods
T7750	29632-29634	,	denotes	,
T7751	29634-29643	VBG	denotes	including
T7752	29644-29647	DT	denotes	the
T7754	29648-29652	RB	denotes	well
T7755	29653-29663	VBN	denotes	documented
T7756	29664-29670	JJ	denotes	direct
T7753	29671-29683	NNS	denotes	interactions
T7757	29684-29688	IN	denotes	with
T7758	29689-29692	DT	denotes	the
T7760	29693-29699	NN	denotes	aurora
T7759	29700-29707	NNS	denotes	kinases
T7761	29708-29711	CC	denotes	and
T7762	29712-29715	DT	denotes	the
T7764	29716-29720	NN	denotes	stu2
T7765	29720-29721	HYPH	denotes	/
T7766	29721-29725	NN	denotes	msps
T7767	29725-29726	HYPH	denotes	/
T7768	29726-29728	NN	denotes	ch
T7770	29728-29729	HYPH	denotes	-
T7769	29729-29732	NN	denotes	TOG
T7763	29733-29739	NN	denotes	family
T7771	29739-29740	.	denotes	.
T7772	29740-31044	sentence	denotes	Figure 6 Functional evolution of the TACC proteins modeled in C. elegans and D. melanogaster. (A). C. elegans interaction map shows empirically defined interactions of ceTAC, and extrapolated interactions defined by [28]. (B): Using the BIND database [29], DTACC directly binds to TBPH and CG14540, and thus indirectly to chromatin remodeling complexes (SWI/SNF and histone acetyltransferases), DNA damage repair machinery (via RAD23), and RNA splicing, transport and translational machinery. (C): Predicted interaction map for vertebrate TACCs, based upon ceTAC, suggests an indirect interaction with the nuclear hormone receptor RXRβ. It is also of interest that this predicts a functional interaction with the LDB family, members of which are also found in TACC containing paralogous segments noted in Figs 2, 3 and Additional file 1. (D): Predicted TACC interaction map based upon DTACC. (E): Vertebrate TACC interactions identified to date. ? denotes uncertainty over the identity of a functional vertebrate homologue. In C, D and E, '*' denotes one or more members of the TACC or Aurora kinase family. Because of the evolutionary conservation of the TACC domain, we would predict that some of the functional interactions seen in C. elegans and D. melanogaster would be observed in higher animals.
T13617	29751-29761	JJ	denotes	Functional
T13618	29762-29771	NN	denotes	evolution
T13619	29772-29774	IN	denotes	of
T13620	29775-29778	DT	denotes	the
T13622	29779-29783	NN	denotes	TACC
T13621	29784-29792	NN	denotes	proteins
T13623	29793-29800	VBN	denotes	modeled
T13624	29801-29803	IN	denotes	in
T13625	29804-29806	NNP	denotes	C.
T13626	29807-29814	NNP	denotes	elegans
T13627	29815-29818	CC	denotes	and
T13628	29819-29821	NNP	denotes	D.
T13629	29822-29834	NNP	denotes	melanogaster
T13630	29834-29835	.	denotes	.
T13631	29835-29963	sentence	denotes	(A). C. elegans interaction map shows empirically defined interactions of ceTAC, and extrapolated interactions defined by [28].
T13632	29836-29837	-LRB-	denotes	(
T13633	29837-29838	LS	denotes	A
T13635	29838-29839	-RRB-	denotes	)
T13636	29839-29840	.	denotes	.
T13637	29841-29843	NNP	denotes	C.
T13638	29844-29851	NNP	denotes	elegans
T13640	29852-29863	NN	denotes	interaction
T13639	29864-29867	NN	denotes	map
T13634	29868-29873	VBZ	denotes	shows
T13641	29874-29885	RB	denotes	empirically
T13642	29886-29893	VBN	denotes	defined
T13643	29894-29906	NNS	denotes	interactions
T13644	29907-29909	IN	denotes	of
T13645	29910-29915	NN	denotes	ceTAC
T13646	29915-29917	,	denotes	,
T13647	29917-29920	CC	denotes	and
T13648	29921-29933	VBN	denotes	extrapolated
T13649	29934-29946	NNS	denotes	interactions
T13650	29947-29954	VBN	denotes	defined
T13651	29955-29957	IN	denotes	by
T13652	29958-29959	-LRB-	denotes	[
T13653	29959-29961	CD	denotes	28
T13654	29961-29962	-RRB-	denotes	]
T13655	29962-29963	.	denotes	.
T13656	29963-30234	sentence	denotes	(B): Using the BIND database [29], DTACC directly binds to TBPH and CG14540, and thus indirectly to chromatin remodeling complexes (SWI/SNF and histone acetyltransferases), DNA damage repair machinery (via RAD23), and RNA splicing, transport and translational machinery.
T13657	29964-29965	-LRB-	denotes	(
T13658	29965-29966	LS	denotes	B
T13660	29966-29967	-RRB-	denotes	)
T13661	29967-29969	:	denotes	:
T13662	29969-29974	VBG	denotes	Using
T13663	29975-29978	DT	denotes	the
T13665	29979-29983	NNP	denotes	BIND
T13664	29984-29992	NN	denotes	database
T13666	29993-29994	-LRB-	denotes	[
T13667	29994-29996	CD	denotes	29
T13668	29996-29997	-RRB-	denotes	]
T13669	29997-29999	,	denotes	,
T13670	29999-30004	NN	denotes	DTACC
T13671	30005-30013	RB	denotes	directly
T13659	30014-30019	VBZ	denotes	binds
T13672	30020-30022	IN	denotes	to
T13673	30023-30027	NN	denotes	TBPH
T13674	30028-30031	CC	denotes	and
T13675	30032-30039	NN	denotes	CG14540
T13676	30039-30041	,	denotes	,
T13677	30041-30044	CC	denotes	and
T13678	30045-30049	RB	denotes	thus
T13679	30050-30060	RB	denotes	indirectly
T13680	30061-30063	IN	denotes	to
T13681	30064-30073	NN	denotes	chromatin
T13682	30074-30084	NN	denotes	remodeling
T13683	30085-30094	NNS	denotes	complexes
T13684	30095-30096	-LRB-	denotes	(
T13685	30096-30099	NN	denotes	SWI
T13687	30099-30100	HYPH	denotes	/
T13686	30100-30103	NN	denotes	SNF
T13688	30104-30107	CC	denotes	and
T13689	30108-30115	NN	denotes	histone
T13690	30116-30134	NNS	denotes	acetyltransferases
T13691	30134-30135	-RRB-	denotes	)
T13692	30135-30137	,	denotes	,
T13693	30137-30140	NN	denotes	DNA
T13694	30141-30147	NN	denotes	damage
T13695	30148-30154	NN	denotes	repair
T13696	30155-30164	NN	denotes	machinery
T13697	30165-30166	-LRB-	denotes	(
T13698	30166-30169	IN	denotes	via
T13699	30170-30175	NN	denotes	RAD23
T13700	30175-30176	-RRB-	denotes	)
T13701	30176-30178	,	denotes	,
T13702	30178-30181	CC	denotes	and
T13703	30182-30185	NN	denotes	RNA
T13704	30186-30194	NN	denotes	splicing
T13706	30194-30196	,	denotes	,
T13707	30196-30205	NN	denotes	transport
T13708	30206-30209	CC	denotes	and
T13709	30210-30223	JJ	denotes	translational
T13705	30224-30233	NN	denotes	machinery
T13710	30233-30234	.	denotes	.
T13711	30234-30378	sentence	denotes	(C): Predicted interaction map for vertebrate TACCs, based upon ceTAC, suggests an indirect interaction with the nuclear hormone receptor RXRβ.
T13712	30235-30236	-LRB-	denotes	(
T13713	30236-30237	LS	denotes	C
T13715	30237-30238	-RRB-	denotes	)
T13716	30238-30240	:	denotes	:
T13717	30240-30249	VBN	denotes	Predicted
T13718	30250-30261	NN	denotes	interaction
T13719	30262-30265	NN	denotes	map
T13720	30266-30269	IN	denotes	for
T13721	30270-30280	NN	denotes	vertebrate
T13722	30281-30286	NNS	denotes	TACCs
T13723	30286-30288	,	denotes	,
T13724	30288-30293	VBN	denotes	based
T13725	30294-30298	IN	denotes	upon
T13726	30299-30304	NN	denotes	ceTAC
T13727	30304-30306	,	denotes	,
T13714	30306-30314	VBZ	denotes	suggests
T13728	30315-30317	DT	denotes	an
T13730	30318-30326	JJ	denotes	indirect
T13729	30327-30338	NN	denotes	interaction
T13731	30339-30343	IN	denotes	with
T13732	30344-30347	DT	denotes	the
T13734	30348-30355	JJ	denotes	nuclear
T13735	30356-30363	NN	denotes	hormone
T13733	30364-30372	NN	denotes	receptor
T13736	30373-30377	NN	denotes	RXRβ
T13737	30377-30378	.	denotes	.
T13738	30378-30579	sentence	denotes	It is also of interest that this predicts a functional interaction with the LDB family, members of which are also found in TACC containing paralogous segments noted in Figs 2, 3 and Additional file 1.
T13739	30379-30381	PRP	denotes	It
T13740	30382-30384	VBZ	denotes	is
T13741	30385-30389	RB	denotes	also
T13742	30390-30392	IN	denotes	of
T13743	30393-30401	NN	denotes	interest
T13744	30402-30406	IN	denotes	that
T13746	30407-30411	DT	denotes	this
T13745	30412-30420	VBZ	denotes	predicts
T13747	30421-30422	DT	denotes	a
T13749	30423-30433	JJ	denotes	functional
T13748	30434-30445	NN	denotes	interaction
T13750	30446-30450	IN	denotes	with
T13751	30451-30454	DT	denotes	the
T13753	30455-30458	NN	denotes	LDB
T13752	30459-30465	NN	denotes	family
T13754	30465-30467	,	denotes	,
T13755	30467-30474	NNS	denotes	members
T13757	30475-30477	IN	denotes	of
T13758	30478-30483	WDT	denotes	which
T13759	30484-30487	VBP	denotes	are
T13760	30488-30492	RB	denotes	also
T13756	30493-30498	VBN	denotes	found
T13761	30499-30501	IN	denotes	in
T13762	30502-30506	NN	denotes	TACC
T13763	30507-30517	VBG	denotes	containing
T13765	30518-30528	JJ	denotes	paralogous
T13764	30529-30537	NNS	denotes	segments
T13766	30538-30543	VBN	denotes	noted
T13767	30544-30546	IN	denotes	in
T13768	30547-30551	NNS	denotes	Figs
T13770	30552-30553	CD	denotes	2
T13771	30553-30555	,	denotes	,
T13769	30555-30556	CD	denotes	3
T13772	30557-30560	CC	denotes	and
T13773	30561-30571	JJ	denotes	Additional
T13774	30572-30576	NN	denotes	file
T13775	30577-30578	CD	denotes	1
T13776	30578-30579	.	denotes	.
T13777	30579-30633	sentence	denotes	(D): Predicted TACC interaction map based upon DTACC.
T13778	30580-30581	-LRB-	denotes	(
T13779	30581-30582	LS	denotes	D
T13781	30582-30583	-RRB-	denotes	)
T13782	30583-30585	:	denotes	:
T13783	30585-30594	VBN	denotes	Predicted
T13784	30595-30599	NN	denotes	TACC
T13785	30600-30611	NN	denotes	interaction
T13780	30612-30615	NN	denotes	map
T13786	30616-30621	VBN	denotes	based
T13787	30622-30626	IN	denotes	upon
T13788	30627-30632	NN	denotes	DTACC
T13789	30632-30633	.	denotes	.
T13790	30633-30687	sentence	denotes	(E): Vertebrate TACC interactions identified to date.
T13791	30634-30635	-LRB-	denotes	(
T13792	30635-30636	LS	denotes	E
T13794	30636-30637	-RRB-	denotes	)
T13795	30637-30639	:	denotes	:
T13796	30639-30649	NN	denotes	Vertebrate
T13797	30650-30654	NN	denotes	TACC
T13793	30655-30667	NNS	denotes	interactions
T13798	30668-30678	VBN	denotes	identified
T13799	30679-30681	IN	denotes	to
T13800	30682-30686	NN	denotes	date
T13801	30686-30687	.	denotes	.
T13802	30687-30765	sentence	denotes	? denotes uncertainty over the identity of a functional vertebrate homologue.
T13803	30688-30689	SYM	denotes	?
T13804	30690-30697	VBZ	denotes	denotes
T13805	30698-30709	NN	denotes	uncertainty
T13806	30710-30714	IN	denotes	over
T13807	30715-30718	DT	denotes	the
T13808	30719-30727	NN	denotes	identity
T13809	30728-30730	IN	denotes	of
T13810	30731-30732	DT	denotes	a
T13812	30733-30743	JJ	denotes	functional
T13813	30744-30754	NN	denotes	vertebrate
T13811	30755-30764	NN	denotes	homologue
T13814	30764-30765	.	denotes	.
T13815	30765-30849	sentence	denotes	In C, D and E, '*' denotes one or more members of the TACC or Aurora kinase family.
T13816	30766-30768	IN	denotes	In
T13818	30769-30770	NN	denotes	C
T13819	30770-30772	,	denotes	,
T13820	30772-30773	NN	denotes	D
T13821	30774-30777	CC	denotes	and
T13822	30778-30779	NN	denotes	E
T13823	30779-30781	,	denotes	,
T13824	30781-30782	``	denotes	'
T13826	30782-30783	SYM	denotes	*
T13825	30783-30784	''	denotes	'
T13817	30785-30792	VBZ	denotes	denotes
T13827	30793-30796	CD	denotes	one
T13829	30797-30799	CC	denotes	or
T13830	30800-30804	JJR	denotes	more
T13828	30805-30812	NNS	denotes	members
T13831	30813-30815	IN	denotes	of
T13832	30816-30819	DT	denotes	the
T13834	30820-30824	NN	denotes	TACC
T13835	30825-30827	CC	denotes	or
T13836	30828-30834	NN	denotes	Aurora
T13837	30835-30841	NN	denotes	kinase
T13833	30842-30848	NN	denotes	family
T13838	30848-30849	.	denotes	.
T7773	30850-30857	IN	denotes	Because
T7775	30858-30860	IN	denotes	of
T7776	30861-30864	DT	denotes	the
T7778	30865-30877	JJ	denotes	evolutionary
T7777	30878-30890	NN	denotes	conservation
T7779	30891-30893	IN	denotes	of
T7780	30894-30897	DT	denotes	the
T7782	30898-30902	NN	denotes	TACC
T7781	30903-30909	NN	denotes	domain
T7783	30909-30911	,	denotes	,
T7784	30911-30913	PRP	denotes	we
T7785	30914-30919	MD	denotes	would
T7774	30920-30927	VB	denotes	predict
T7786	30928-30932	IN	denotes	that
T7788	30933-30937	DT	denotes	some
T7789	30938-30940	IN	denotes	of
T7790	30941-30944	DT	denotes	the
T7792	30945-30955	JJ	denotes	functional
T7791	30956-30968	NNS	denotes	interactions
T7793	30969-30973	VBN	denotes	seen
T7794	30974-30976	IN	denotes	in
T7795	30977-30979	NNP	denotes	C.
T7796	30980-30987	NNP	denotes	elegans
T7797	30988-30991	CC	denotes	and
T7798	30992-30994	NNP	denotes	D.
T7799	30995-31007	NNP	denotes	melanogaster
T7800	31008-31013	MD	denotes	would
T7801	31014-31016	VB	denotes	be
T7787	31017-31025	VBN	denotes	observed
T7802	31026-31028	IN	denotes	in
T7803	31029-31035	JJR	denotes	higher
T7804	31036-31043	NNS	denotes	animals
T7805	31043-31044	.	denotes	.
T7806	31044-31186	sentence	denotes	Phylogenetic profiling from these interaction maps suggests two similar sets of predicted interactions for vertebrate TACCs (Fig. 6C and 6D).
T7807	31045-31057	JJ	denotes	Phylogenetic
T7808	31058-31067	NN	denotes	profiling
T7810	31068-31072	IN	denotes	from
T7811	31073-31078	DT	denotes	these
T7813	31079-31090	NN	denotes	interaction
T7812	31091-31095	NNS	denotes	maps
T7809	31096-31104	VBZ	denotes	suggests
T7814	31105-31108	CD	denotes	two
T7816	31109-31116	JJ	denotes	similar
T7815	31117-31121	NNS	denotes	sets
T7817	31122-31124	IN	denotes	of
T7818	31125-31134	VBN	denotes	predicted
T7819	31135-31147	NNS	denotes	interactions
T7820	31148-31151	IN	denotes	for
T7821	31152-31162	NN	denotes	vertebrate
T7822	31163-31168	NNS	denotes	TACCs
T7823	31169-31170	-LRB-	denotes	(
T7825	31170-31174	NN	denotes	Fig.
T7824	31175-31177	CD	denotes	6C
T7826	31178-31181	CC	denotes	and
T7827	31182-31184	CD	denotes	6D
T7828	31184-31185	-RRB-	denotes	)
T7829	31185-31186	.	denotes	.
T7830	31186-31523	sentence	denotes	Strikingly, however, the C. elegans specific proteins lin15A, lin36 and lin37 do not have readily discernible homologues in vertebrates or Drosophila, although the presence of a zinc finger domain in lin36 may suggest that this protein is involved directly in transcription or perform an adaptor role similar to LIM containing proteins.
T7831	31187-31197	RB	denotes	Strikingly
T7833	31197-31199	,	denotes	,
T7834	31199-31206	RB	denotes	however
T7835	31206-31208	,	denotes	,
T7836	31208-31211	DT	denotes	the
T7838	31212-31214	NNP	denotes	C.
T7839	31215-31222	NNP	denotes	elegans
T7840	31223-31231	JJ	denotes	specific
T7837	31232-31240	NN	denotes	proteins
T7841	31241-31247	NN	denotes	lin15A
T7842	31247-31249	,	denotes	,
T7843	31249-31254	NN	denotes	lin36
T7844	31255-31258	CC	denotes	and
T7845	31259-31264	NN	denotes	lin37
T7846	31265-31267	VBP	denotes	do
T7847	31268-31271	RB	denotes	not
T7832	31272-31276	VB	denotes	have
T7848	31277-31284	RB	denotes	readily
T7849	31285-31296	JJ	denotes	discernible
T7850	31297-31307	NNS	denotes	homologues
T7851	31308-31310	IN	denotes	in
T7852	31311-31322	NNS	denotes	vertebrates
T7853	31323-31325	CC	denotes	or
T7854	31326-31336	NNP	denotes	Drosophila
T7855	31336-31338	,	denotes	,
T7856	31338-31346	IN	denotes	although
T7858	31347-31350	DT	denotes	the
T7859	31351-31359	NN	denotes	presence
T7860	31360-31362	IN	denotes	of
T7861	31363-31364	DT	denotes	a
T7863	31365-31369	NN	denotes	zinc
T7864	31370-31376	NN	denotes	finger
T7862	31377-31383	NN	denotes	domain
T7865	31384-31386	IN	denotes	in
T7866	31387-31392	NN	denotes	lin36
T7867	31393-31396	MD	denotes	may
T7857	31397-31404	VB	denotes	suggest
T7868	31405-31409	IN	denotes	that
T7870	31410-31414	DT	denotes	this
T7871	31415-31422	NN	denotes	protein
T7872	31423-31425	VBZ	denotes	is
T7869	31426-31434	VBN	denotes	involved
T7873	31435-31443	RB	denotes	directly
T7874	31444-31446	IN	denotes	in
T7875	31447-31460	NN	denotes	transcription
T7876	31461-31463	CC	denotes	or
T7877	31464-31471	VB	denotes	perform
T7878	31472-31474	DT	denotes	an
T7880	31475-31482	NN	denotes	adaptor
T7879	31483-31487	NN	denotes	role
T7881	31488-31495	JJ	denotes	similar
T7882	31496-31498	IN	denotes	to
T7883	31499-31502	NN	denotes	LIM
T7884	31503-31513	VBG	denotes	containing
T7885	31514-31522	NN	denotes	proteins
T7886	31522-31523	.	denotes	.
T7887	31523-31659	sentence	denotes	For the DTACC interacting proteins, TBPH corresponds to TDP43, a protein implicated in transcriptional regulation and splicing [31,32].
T7888	31524-31527	IN	denotes	For
T7890	31528-31531	DT	denotes	the
T7892	31532-31537	NN	denotes	DTACC
T7893	31538-31549	VBG	denotes	interacting
T7891	31550-31558	NN	denotes	proteins
T7894	31558-31560	,	denotes	,
T7895	31560-31564	NN	denotes	TBPH
T7889	31565-31576	VBZ	denotes	corresponds
T7896	31577-31579	IN	denotes	to
T7897	31580-31585	NN	denotes	TDP43
T7898	31585-31587	,	denotes	,
T7899	31587-31588	DT	denotes	a
T7900	31589-31596	NN	denotes	protein
T7901	31597-31607	VBN	denotes	implicated
T7902	31608-31610	IN	denotes	in
T7903	31611-31626	JJ	denotes	transcriptional
T7904	31627-31637	NN	denotes	regulation
T7905	31638-31641	CC	denotes	and
T7906	31642-31650	NN	denotes	splicing
T7907	31651-31652	-LRB-	denotes	[
T7909	31652-31654	CD	denotes	31
T7910	31654-31655	,	denotes	,
T7908	31655-31657	CD	denotes	32
T7911	31657-31658	-RRB-	denotes	]
T7912	31658-31659	.	denotes	.
T7913	31659-31877	sentence	denotes	However, the assignment of the human homologue of CG14540 is less clear, with the closest matches in the human databases corresponding to glutamine rich transcription factors such as CREB and the G-box binding factor.
T7914	31660-31667	RB	denotes	However
T7916	31667-31669	,	denotes	,
T7917	31669-31672	DT	denotes	the
T7918	31673-31683	NN	denotes	assignment
T7919	31684-31686	IN	denotes	of
T7920	31687-31690	DT	denotes	the
T7922	31691-31696	JJ	denotes	human
T7921	31697-31706	NN	denotes	homologue
T7923	31707-31709	IN	denotes	of
T7924	31710-31717	NN	denotes	CG14540
T7915	31718-31720	VBZ	denotes	is
T7925	31721-31725	RBR	denotes	less
T7926	31726-31731	JJ	denotes	clear
T7927	31731-31733	,	denotes	,
T7928	31733-31737	IN	denotes	with
T7929	31738-31741	DT	denotes	the
T7931	31742-31749	JJS	denotes	closest
T7930	31750-31757	NNS	denotes	matches
T7933	31758-31760	IN	denotes	in
T7934	31761-31764	DT	denotes	the
T7936	31765-31770	JJ	denotes	human
T7935	31771-31780	NNS	denotes	databases
T7932	31781-31794	VBG	denotes	corresponding
T7937	31795-31797	IN	denotes	to
T7938	31798-31807	NN	denotes	glutamine
T7939	31808-31812	JJ	denotes	rich
T7941	31813-31826	NN	denotes	transcription
T7940	31827-31834	NNS	denotes	factors
T7942	31835-31839	JJ	denotes	such
T7943	31840-31842	IN	denotes	as
T7944	31843-31847	NN	denotes	CREB
T7945	31848-31851	CC	denotes	and
T7946	31852-31855	DT	denotes	the
T7948	31856-31857	NN	denotes	G
T7950	31857-31858	HYPH	denotes	-
T7949	31858-31861	NN	denotes	box
T7951	31862-31869	NN	denotes	binding
T7947	31870-31876	NN	denotes	factor
T7952	31876-31877	.	denotes	.
T8332	31879-31889	NN	denotes	Comparison
T8333	31890-31892	IN	denotes	of
T8334	31893-31900	VBN	denotes	modeled
T8335	31901-31905	IN	denotes	with
T8336	31906-31920	RB	denotes	experimentally
T8337	31921-31928	VBN	denotes	defined
T8338	31929-31941	NNS	denotes	interactions
T8339	31942-31944	IN	denotes	of
T8340	31945-31948	DT	denotes	the
T8342	31949-31959	NN	denotes	vertebrate
T8343	31960-31964	NN	denotes	TACC
T8341	31965-31973	NN	denotes	proteins
T8344	31973-32101	sentence	denotes	The interaction data for the vertebrate TACCs is relatively limited; however, interaction networks are now beginning to emerge.
T8345	31974-31977	DT	denotes	The
T8347	31978-31989	NN	denotes	interaction
T8346	31990-31994	NNS	denotes	data
T8349	31995-31998	IN	denotes	for
T8350	31999-32002	DT	denotes	the
T8352	32003-32013	NN	denotes	vertebrate
T8351	32014-32019	NNS	denotes	TACCs
T8348	32020-32022	VBZ	denotes	is
T8354	32023-32033	RB	denotes	relatively
T8355	32034-32041	VBN	denotes	limited
T8356	32041-32042	:	denotes	;
T8357	32043-32050	RB	denotes	however
T8358	32050-32052	,	denotes	,
T8359	32052-32063	NN	denotes	interaction
T8360	32064-32072	NNS	denotes	networks
T8361	32073-32076	VBP	denotes	are
T8362	32077-32080	RB	denotes	now
T8353	32081-32090	VBG	denotes	beginning
T8363	32091-32093	TO	denotes	to
T8364	32094-32100	VB	denotes	emerge
T8365	32100-32101	.	denotes	.
T8366	32101-32287	sentence	denotes	The results of our functional analysis, as well as other published data clearly indicate that the vertebrate TACCs interact with proteins that can be divided into two broad categories:
T8367	32102-32105	DT	denotes	The
T8368	32106-32113	NNS	denotes	results
T8370	32114-32116	IN	denotes	of
T8371	32117-32120	PRP$	denotes	our
T8373	32121-32131	JJ	denotes	functional
T8372	32132-32140	NN	denotes	analysis
T8374	32140-32142	,	denotes	,
T8375	32142-32144	RB	denotes	as
T8377	32145-32149	RB	denotes	well
T8376	32150-32152	IN	denotes	as
T8378	32153-32158	JJ	denotes	other
T8380	32159-32168	VBN	denotes	published
T8379	32169-32173	NNS	denotes	data
T8381	32174-32181	RB	denotes	clearly
T8369	32182-32190	VBP	denotes	indicate
T8382	32191-32195	IN	denotes	that
T8384	32196-32199	DT	denotes	the
T8386	32200-32210	NN	denotes	vertebrate
T8385	32211-32216	NNS	denotes	TACCs
T8383	32217-32225	VBP	denotes	interact
T8387	32226-32230	IN	denotes	with
T8388	32231-32239	NN	denotes	proteins
T8389	32240-32244	WDT	denotes	that
T8391	32245-32248	MD	denotes	can
T8392	32249-32251	VB	denotes	be
T8390	32252-32259	VBN	denotes	divided
T8393	32260-32264	IN	denotes	into
T8394	32265-32268	CD	denotes	two
T8396	32269-32274	JJ	denotes	broad
T8395	32275-32285	NNS	denotes	categories
T8397	32285-32287	:	denotes	:
T8398	32287-32288	LS	denotes	1
T8400	32287-32507	sentence	denotes	1) proteins with roles in centrosome/mitotic spindle dynamics, and 2) proteins involved in gene regulation, either at the level of transcription, or subsequent RNA processing and translation [3,5-7,15,19-21,24,25,33,34].
T8401	32288-32289	-RRB-	denotes	)
T8399	32290-32298	NN	denotes	proteins
T8402	32299-32303	IN	denotes	with
T8403	32304-32309	NNS	denotes	roles
T8404	32310-32312	IN	denotes	in
T8405	32313-32323	NN	denotes	centrosome
T8407	32323-32324	HYPH	denotes	/
T8406	32324-32331	JJ	denotes	mitotic
T8408	32332-32339	NN	denotes	spindle
T8409	32340-32348	NNS	denotes	dynamics
T8410	32348-32350	,	denotes	,
T8411	32350-32353	CC	denotes	and
T8412	32354-32355	LS	denotes	2
T8414	32355-32356	-RRB-	denotes	)
T8413	32357-32365	NN	denotes	proteins
T8415	32366-32374	VBN	denotes	involved
T8416	32375-32377	IN	denotes	in
T8417	32378-32382	NN	denotes	gene
T8418	32383-32393	NN	denotes	regulation
T8419	32393-32395	,	denotes	,
T8420	32395-32401	CC	denotes	either
T8421	32402-32404	IN	denotes	at
T8422	32405-32408	DT	denotes	the
T8423	32409-32414	NN	denotes	level
T8424	32415-32417	IN	denotes	of
T8425	32418-32431	NN	denotes	transcription
T8426	32431-32433	,	denotes	,
T8427	32433-32435	CC	denotes	or
T8428	32436-32446	JJ	denotes	subsequent
T8430	32447-32450	NN	denotes	RNA
T8429	32451-32461	NN	denotes	processing
T8431	32462-32465	CC	denotes	and
T8432	32466-32477	NN	denotes	translation
T8433	32478-32479	-LRB-	denotes	[
T8434	32479-32480	CD	denotes	3
T8435	32480-32481	,	denotes	,
T8436	32481-32482	CD	denotes	5
T8437	32482-32483	SYM	denotes	-
T8438	32483-32484	CD	denotes	7
T8439	32484-32485	,	denotes	,
T8440	32485-32487	CD	denotes	15
T8441	32487-32488	,	denotes	,
T8442	32488-32490	CD	denotes	19
T8443	32490-32491	SYM	denotes	-
T8444	32491-32493	CD	denotes	21
T8445	32493-32494	,	denotes	,
T8446	32494-32496	CD	denotes	24
T8447	32496-32497	,	denotes	,
T8448	32497-32499	CD	denotes	25
T8449	32499-32500	,	denotes	,
T8450	32500-32502	CD	denotes	33
T8451	32502-32503	,	denotes	,
T8452	32503-32505	CD	denotes	34
T8453	32505-32506	-RRB-	denotes	]
T8454	32506-32507	.	denotes	.
T8455	32507-32662	sentence	denotes	Many of these proteins do not appear to interact directly with the protostome TACCs, but would be expected to be in the same protein complex (Fig. 6C,6D).
T8456	32508-32512	JJ	denotes	Many
T8458	32513-32515	IN	denotes	of
T8459	32516-32521	DT	denotes	these
T8460	32522-32530	NN	denotes	proteins
T8461	32531-32533	VBP	denotes	do
T8462	32534-32537	RB	denotes	not
T8457	32538-32544	VB	denotes	appear
T8463	32545-32547	TO	denotes	to
T8464	32548-32556	VB	denotes	interact
T8465	32557-32565	RB	denotes	directly
T8466	32566-32570	IN	denotes	with
T8467	32571-32574	DT	denotes	the
T8469	32575-32585	NN	denotes	protostome
T8468	32586-32591	NNS	denotes	TACCs
T8470	32591-32593	,	denotes	,
T8471	32593-32596	CC	denotes	but
T8472	32597-32602	MD	denotes	would
T8474	32603-32605	VB	denotes	be
T8473	32606-32614	VBN	denotes	expected
T8475	32615-32617	TO	denotes	to
T8476	32618-32620	VB	denotes	be
T8477	32621-32623	IN	denotes	in
T8478	32624-32627	DT	denotes	the
T8480	32628-32632	JJ	denotes	same
T8481	32633-32640	NN	denotes	protein
T8479	32641-32648	NN	denotes	complex
T8482	32649-32650	-LRB-	denotes	(
T8484	32650-32654	NN	denotes	Fig.
T8485	32655-32657	CD	denotes	6C
T8486	32657-32658	,	denotes	,
T8483	32658-32660	CD	denotes	6D
T8487	32660-32661	-RRB-	denotes	)
T8488	32661-32662	.	denotes	.
T8489	32662-32833	sentence	denotes	Significant analysis of the association of the TACCs with the centrosome and the dynamics of mitotic spindle assembly from yeast to humans has been published [5,6,21-24].
T8490	32663-32674	JJ	denotes	Significant
T8491	32675-32683	NN	denotes	analysis
T8493	32684-32686	IN	denotes	of
T8494	32687-32690	DT	denotes	the
T8495	32691-32702	NN	denotes	association
T8496	32703-32705	IN	denotes	of
T8497	32706-32709	DT	denotes	the
T8498	32710-32715	NNS	denotes	TACCs
T8499	32716-32720	IN	denotes	with
T8500	32721-32724	DT	denotes	the
T8501	32725-32735	NN	denotes	centrosome
T8502	32736-32739	CC	denotes	and
T8503	32740-32743	DT	denotes	the
T8504	32744-32752	NNS	denotes	dynamics
T8505	32753-32755	IN	denotes	of
T8506	32756-32763	JJ	denotes	mitotic
T8507	32764-32771	NN	denotes	spindle
T8508	32772-32780	NN	denotes	assembly
T8509	32781-32785	IN	denotes	from
T8510	32786-32791	NN	denotes	yeast
T8511	32792-32794	IN	denotes	to
T8512	32795-32801	NNS	denotes	humans
T8513	32802-32805	VBZ	denotes	has
T8514	32806-32810	VBN	denotes	been
T8492	32811-32820	VBN	denotes	published
T8515	32821-32822	-LRB-	denotes	[
T8516	32822-32823	CD	denotes	5
T8517	32823-32824	,	denotes	,
T8518	32824-32825	CD	denotes	6
T8519	32825-32826	,	denotes	,
T8520	32826-32828	CD	denotes	21
T8521	32828-32829	SYM	denotes	-
T8522	32829-32831	CD	denotes	24
T8523	32831-32832	-RRB-	denotes	]
T8524	32832-32833	.	denotes	.
T8525	32833-33153	sentence	denotes	From this analysis, it seems likely that the vertebrate TACC3 protein has retained this direct ancestral function, based upon its location in these structures during mitosis [27], its strong interaction with Aurora Kinase A, and the observation that it is the only human TACC protein phosphorylated by this enzyme [21].
T8526	32834-32838	IN	denotes	From
T8528	32839-32843	DT	denotes	this
T8529	32844-32852	NN	denotes	analysis
T8530	32852-32854	,	denotes	,
T8531	32854-32856	PRP	denotes	it
T8527	32857-32862	VBZ	denotes	seems
T8532	32863-32869	JJ	denotes	likely
T8533	32870-32874	IN	denotes	that
T8535	32875-32878	DT	denotes	the
T8537	32879-32889	NN	denotes	vertebrate
T8538	32890-32895	NN	denotes	TACC3
T8536	32896-32903	NN	denotes	protein
T8539	32904-32907	VBZ	denotes	has
T8534	32908-32916	VBN	denotes	retained
T8540	32917-32921	DT	denotes	this
T8542	32922-32928	JJ	denotes	direct
T8543	32929-32938	JJ	denotes	ancestral
T8541	32939-32947	NN	denotes	function
T8544	32947-32949	,	denotes	,
T8545	32949-32954	VBN	denotes	based
T8546	32955-32959	IN	denotes	upon
T8547	32960-32963	PRP$	denotes	its
T8548	32964-32972	NN	denotes	location
T8549	32973-32975	IN	denotes	in
T8550	32976-32981	DT	denotes	these
T8551	32982-32992	NNS	denotes	structures
T8552	32993-32999	IN	denotes	during
T8553	33000-33007	NN	denotes	mitosis
T8554	33008-33009	-LRB-	denotes	[
T8555	33009-33011	CD	denotes	27
T8556	33011-33012	-RRB-	denotes	]
T8557	33012-33014	,	denotes	,
T8558	33014-33017	PRP$	denotes	its
T8560	33018-33024	JJ	denotes	strong
T8559	33025-33036	NN	denotes	interaction
T8561	33037-33041	IN	denotes	with
T8562	33042-33048	NN	denotes	Aurora
T8564	33049-33055	NN	denotes	Kinase
T8563	33056-33057	NN	denotes	A
T8565	33057-33059	,	denotes	,
T8566	33059-33062	CC	denotes	and
T8567	33063-33066	DT	denotes	the
T8568	33067-33078	NN	denotes	observation
T8569	33079-33083	IN	denotes	that
T8571	33084-33086	PRP	denotes	it
T8570	33087-33089	VBZ	denotes	is
T8572	33090-33093	DT	denotes	the
T8574	33094-33098	RB	denotes	only
T8575	33099-33104	JJ	denotes	human
T8576	33105-33109	NN	denotes	TACC
T8573	33110-33117	NN	denotes	protein
T8577	33118-33132	VBN	denotes	phosphorylated
T8578	33133-33135	IN	denotes	by
T8579	33136-33140	DT	denotes	this
T8580	33141-33147	NN	denotes	enzyme
T8581	33148-33149	-LRB-	denotes	[
T8582	33149-33151	CD	denotes	21
T8583	33151-33152	-RRB-	denotes	]
T8584	33152-33153	.	denotes	.
T8585	33153-33337	sentence	denotes	However, the variability of the central domain of the vertebrate orthologues, suggests that TACC3 may also have acquired additional, and in some instances, species-specific functions.
T8586	33154-33161	RB	denotes	However
T8588	33161-33163	,	denotes	,
T8589	33163-33166	DT	denotes	the
T8590	33167-33178	NN	denotes	variability
T8591	33179-33181	IN	denotes	of
T8592	33182-33185	DT	denotes	the
T8594	33186-33193	JJ	denotes	central
T8593	33194-33200	NN	denotes	domain
T8595	33201-33203	IN	denotes	of
T8596	33204-33207	DT	denotes	the
T8598	33208-33218	NN	denotes	vertebrate
T8597	33219-33230	NNS	denotes	orthologues
T8599	33230-33232	,	denotes	,
T8587	33232-33240	VBZ	denotes	suggests
T8600	33241-33245	IN	denotes	that
T8602	33246-33251	NN	denotes	TACC3
T8603	33252-33255	MD	denotes	may
T8604	33256-33260	RB	denotes	also
T8605	33261-33265	VB	denotes	have
T8601	33266-33274	VBN	denotes	acquired
T8606	33275-33285	JJ	denotes	additional
T8608	33285-33287	,	denotes	,
T8609	33287-33290	CC	denotes	and
T8610	33291-33293	IN	denotes	in
T8612	33294-33298	DT	denotes	some
T8613	33299-33308	NNS	denotes	instances
T8614	33308-33310	,	denotes	,
T8615	33310-33317	NN	denotes	species
T8616	33317-33318	HYPH	denotes	-
T8611	33318-33326	JJ	denotes	specific
T8607	33327-33336	NNS	denotes	functions
T8617	33336-33337	.	denotes	.
T8618	33337-33547	sentence	denotes	For instance, in X. laevis, the maskin protein has acquired a binding site for the eIF4E protein, and thus a function in the coordinated control of polyadenylation and translation in the Xenopus oocyte [8,35].
T8619	33338-33341	IN	denotes	For
T8621	33342-33350	NN	denotes	instance
T8622	33350-33352	,	denotes	,
T8623	33352-33354	IN	denotes	in
T8624	33355-33357	NNP	denotes	X.
T8625	33358-33364	NNP	denotes	laevis
T8626	33364-33366	,	denotes	,
T8627	33366-33369	DT	denotes	the
T8629	33370-33376	NN	denotes	maskin
T8628	33377-33384	NN	denotes	protein
T8630	33385-33388	VBZ	denotes	has
T8620	33389-33397	VBN	denotes	acquired
T8631	33398-33399	DT	denotes	a
T8633	33400-33407	NN	denotes	binding
T8632	33408-33412	NN	denotes	site
T8634	33413-33416	IN	denotes	for
T8635	33417-33420	DT	denotes	the
T8637	33421-33426	NN	denotes	eIF4E
T8636	33427-33434	NN	denotes	protein
T8638	33434-33436	,	denotes	,
T8639	33436-33439	CC	denotes	and
T8640	33440-33444	RB	denotes	thus
T8642	33445-33446	DT	denotes	a
T8641	33447-33455	NN	denotes	function
T8643	33456-33458	IN	denotes	in
T8644	33459-33462	DT	denotes	the
T8646	33463-33474	VBN	denotes	coordinated
T8645	33475-33482	NN	denotes	control
T8647	33483-33485	IN	denotes	of
T8648	33486-33501	NN	denotes	polyadenylation
T8649	33502-33505	CC	denotes	and
T8650	33506-33517	NN	denotes	translation
T8651	33518-33520	IN	denotes	in
T8652	33521-33524	DT	denotes	the
T8654	33525-33532	NNP	denotes	Xenopus
T8653	33533-33539	NN	denotes	oocyte
T8655	33540-33541	-LRB-	denotes	[
T8657	33541-33542	CD	denotes	8
T8658	33542-33543	,	denotes	,
T8656	33543-33545	CD	denotes	35
T8659	33545-33546	-RRB-	denotes	]
T8660	33546-33547	.	denotes	.
T8661	33547-33801	sentence	denotes	A recent study has suggested that this function may be unique to maskin: although it is unclear whether the other vertebrate TACC3 proteins interact with the eIF4E/CPEB complex, the human TACC1A isoform is unable to interact with the eIF4E/CPEB complex.
T8662	33548-33549	DT	denotes	A
T8664	33550-33556	JJ	denotes	recent
T8663	33557-33562	NN	denotes	study
T8666	33563-33566	VBZ	denotes	has
T8665	33567-33576	VBN	denotes	suggested
T8668	33577-33581	IN	denotes	that
T8670	33582-33586	DT	denotes	this
T8671	33587-33595	NN	denotes	function
T8672	33596-33599	MD	denotes	may
T8669	33600-33602	VB	denotes	be
T8673	33603-33609	JJ	denotes	unique
T8674	33610-33612	IN	denotes	to
T8675	33613-33619	NN	denotes	maskin
T8676	33619-33621	:	denotes	:
T8677	33621-33629	IN	denotes	although
T8679	33630-33632	PRP	denotes	it
T8678	33633-33635	VBZ	denotes	is
T8680	33636-33643	JJ	denotes	unclear
T8681	33644-33651	IN	denotes	whether
T8683	33652-33655	DT	denotes	the
T8685	33656-33661	JJ	denotes	other
T8686	33662-33672	NN	denotes	vertebrate
T8687	33673-33678	NN	denotes	TACC3
T8684	33679-33687	NN	denotes	proteins
T8682	33688-33696	VBP	denotes	interact
T8688	33697-33701	IN	denotes	with
T8689	33702-33705	DT	denotes	the
T8691	33706-33711	NN	denotes	eIF4E
T8693	33711-33712	HYPH	denotes	/
T8692	33712-33716	NN	denotes	CPEB
T8690	33717-33724	NN	denotes	complex
T8694	33724-33726	,	denotes	,
T8695	33726-33729	DT	denotes	the
T8697	33730-33735	JJ	denotes	human
T8698	33736-33742	NN	denotes	TACC1A
T8696	33743-33750	NN	denotes	isoform
T8667	33751-33753	VBZ	denotes	is
T8699	33754-33760	JJ	denotes	unable
T8700	33761-33763	TO	denotes	to
T8701	33764-33772	VB	denotes	interact
T8702	33773-33777	IN	denotes	with
T8703	33778-33781	DT	denotes	the
T8705	33782-33787	NN	denotes	eIF4E
T8707	33787-33788	HYPH	denotes	/
T8706	33788-33792	NN	denotes	CPEB
T8704	33793-33800	NN	denotes	complex
T8708	33800-33801	.	denotes	.
T8709	33801-33964	sentence	denotes	Instead, some TACC1 isoforms have evolved a related, but distinct function by directly interacting with elements of the RNA splicing and transport machinery [19].
T8710	33802-33809	RB	denotes	Instead
T8712	33809-33811	,	denotes	,
T8713	33811-33815	DT	denotes	some
T8715	33816-33821	NN	denotes	TACC1
T8714	33822-33830	NNS	denotes	isoforms
T8716	33831-33835	VBP	denotes	have
T8711	33836-33843	VBN	denotes	evolved
T8717	33844-33845	DT	denotes	a
T8719	33846-33853	JJ	denotes	related
T8720	33853-33855	,	denotes	,
T8721	33855-33858	CC	denotes	but
T8722	33859-33867	JJ	denotes	distinct
T8718	33868-33876	NN	denotes	function
T8723	33877-33879	IN	denotes	by
T8724	33880-33888	RB	denotes	directly
T8725	33889-33900	VBG	denotes	interacting
T8726	33901-33905	IN	denotes	with
T8727	33906-33914	NNS	denotes	elements
T8728	33915-33917	IN	denotes	of
T8729	33918-33921	DT	denotes	the
T8731	33922-33925	NN	denotes	RNA
T8732	33926-33934	NN	denotes	splicing
T8733	33935-33938	CC	denotes	and
T8734	33939-33948	NN	denotes	transport
T8730	33949-33958	NN	denotes	machinery
T8735	33959-33960	-LRB-	denotes	[
T8736	33960-33962	CD	denotes	19
T8737	33962-33963	-RRB-	denotes	]
T8738	33963-33964	.	denotes	.
T8739	33964-34158	sentence	denotes	To further characterize the evolving functions of the TACC proteins, we have used an unbiased yeast two hybrid screening method to identify proteins that bind to the human TACC proteins [3,34].
T8740	33965-33967	TO	denotes	To
T8742	33968-33975	RB	denotes	further
T8741	33976-33988	VB	denotes	characterize
T8744	33989-33992	DT	denotes	the
T8746	33993-34001	VBG	denotes	evolving
T8745	34002-34011	NNS	denotes	functions
T8747	34012-34014	IN	denotes	of
T8748	34015-34018	DT	denotes	the
T8750	34019-34023	NN	denotes	TACC
T8749	34024-34032	NN	denotes	proteins
T8751	34032-34034	,	denotes	,
T8752	34034-34036	PRP	denotes	we
T8753	34037-34041	VBP	denotes	have
T8743	34042-34046	VBN	denotes	used
T8754	34047-34049	DT	denotes	an
T8756	34050-34058	JJ	denotes	unbiased
T8757	34059-34064	NN	denotes	yeast
T8758	34065-34068	CD	denotes	two
T8759	34069-34075	NN	denotes	hybrid
T8760	34076-34085	NN	denotes	screening
T8755	34086-34092	NN	denotes	method
T8761	34093-34095	TO	denotes	to
T8762	34096-34104	VB	denotes	identify
T8763	34105-34113	NN	denotes	proteins
T8764	34114-34118	WDT	denotes	that
T8765	34119-34123	VBP	denotes	bind
T8766	34124-34126	IN	denotes	to
T8767	34127-34130	DT	denotes	the
T8769	34131-34136	JJ	denotes	human
T8770	34137-34141	NN	denotes	TACC
T8768	34142-34150	NN	denotes	proteins
T8771	34151-34152	-LRB-	denotes	[
T8773	34152-34153	CD	denotes	3
T8774	34153-34154	,	denotes	,
T8772	34154-34156	CD	denotes	34
T8775	34156-34157	-RRB-	denotes	]
T8776	34157-34158	.	denotes	.
T8777	34158-34420	sentence	denotes	In a screen of a MATCHMAKER fetal brain library (BD Biosciences Clontech), in addition to isolating the histone acetyltransferase hGCN5L2 [34], we also identified the β3 isoform of retinoid-X receptor β as a protein that interacts with the TACC domain of TACC2.
T8778	34159-34161	IN	denotes	In
T8780	34162-34163	DT	denotes	a
T8781	34164-34170	NN	denotes	screen
T8782	34171-34173	IN	denotes	of
T8783	34174-34175	DT	denotes	a
T8785	34176-34186	NN	denotes	MATCHMAKER
T8786	34187-34192	JJ	denotes	fetal
T8787	34193-34198	NN	denotes	brain
T8784	34199-34206	NN	denotes	library
T8788	34207-34208	-LRB-	denotes	(
T8790	34208-34210	NNP	denotes	BD
T8791	34211-34222	NNPS	denotes	Biosciences
T8789	34223-34231	NNP	denotes	Clontech
T8792	34231-34232	-RRB-	denotes	)
T8793	34232-34234	,	denotes	,
T8794	34234-34236	IN	denotes	in
T8795	34237-34245	NN	denotes	addition
T8796	34246-34248	IN	denotes	to
T8797	34249-34258	VBG	denotes	isolating
T8798	34259-34262	DT	denotes	the
T8800	34263-34270	NN	denotes	histone
T8799	34271-34288	NN	denotes	acetyltransferase
T8801	34289-34296	NN	denotes	hGCN5L2
T8802	34297-34298	-LRB-	denotes	[
T8803	34298-34300	CD	denotes	34
T8804	34300-34301	-RRB-	denotes	]
T8805	34301-34303	,	denotes	,
T8806	34303-34305	PRP	denotes	we
T8807	34306-34310	RB	denotes	also
T8779	34311-34321	VBD	denotes	identified
T8808	34322-34325	DT	denotes	the
T8810	34326-34328	NN	denotes	β3
T8809	34329-34336	NN	denotes	isoform
T8811	34337-34339	IN	denotes	of
T8812	34340-34348	NN	denotes	retinoid
T8814	34348-34349	HYPH	denotes	-
T8813	34349-34350	NN	denotes	X
T8816	34351-34359	NN	denotes	receptor
T8815	34360-34361	NN	denotes	β
T8817	34362-34364	IN	denotes	as
T8818	34365-34366	DT	denotes	a
T8819	34367-34374	NN	denotes	protein
T8820	34375-34379	WDT	denotes	that
T8821	34380-34389	VBZ	denotes	interacts
T8822	34390-34394	IN	denotes	with
T8823	34395-34398	DT	denotes	the
T8825	34399-34403	NN	denotes	TACC
T8824	34404-34410	NN	denotes	domain
T8826	34411-34413	IN	denotes	of
T8827	34414-34419	NN	denotes	TACC2
T8828	34419-34420	.	denotes	.
T8829	34420-34506	sentence	denotes	As shown in Fig. 7, this interaction is confirmed in vitro by GST-pull down analysis.
T8830	34421-34423	IN	denotes	As
T8831	34424-34429	VBN	denotes	shown
T8833	34430-34432	IN	denotes	in
T8834	34433-34437	NN	denotes	Fig.
T8835	34438-34439	CD	denotes	7
T8836	34439-34441	,	denotes	,
T8837	34441-34445	DT	denotes	this
T8838	34446-34457	NN	denotes	interaction
T8839	34458-34460	VBZ	denotes	is
T8832	34461-34470	VBN	denotes	confirmed
T8840	34471-34473	FW	denotes	in
T8841	34474-34479	FW	denotes	vitro
T8842	34480-34482	IN	denotes	by
T8843	34483-34486	NN	denotes	GST
T8845	34486-34487	HYPH	denotes	-
T8844	34487-34491	VB	denotes	pull
T8847	34492-34496	RP	denotes	down
T8846	34497-34505	NN	denotes	analysis
T8848	34505-34506	.	denotes	.
T8849	34506-34675	sentence	denotes	Significantly, RXRβ is a close family relative of the nuclear hormone receptor, nhr-86, from C. elegans, which interacts with the ceTAC binding protein lin36 (Fig. 6A).
T8850	34507-34520	RB	denotes	Significantly
T8852	34520-34522	,	denotes	,
T8853	34522-34526	NN	denotes	RXRβ
T8851	34527-34529	VBZ	denotes	is
T8854	34530-34531	DT	denotes	a
T8856	34532-34537	JJ	denotes	close
T8855	34538-34544	NN	denotes	family
T8857	34545-34553	JJ	denotes	relative
T8858	34554-34556	IN	denotes	of
T8859	34557-34560	DT	denotes	the
T8861	34561-34568	JJ	denotes	nuclear
T8862	34569-34576	NN	denotes	hormone
T8860	34577-34585	NN	denotes	receptor
T8863	34585-34587	,	denotes	,
T8864	34587-34590	NN	denotes	nhr
T8865	34590-34591	HYPH	denotes	-
T8866	34591-34593	CD	denotes	86
T8867	34593-34595	,	denotes	,
T8868	34595-34599	IN	denotes	from
T8869	34600-34602	NNP	denotes	C.
T8870	34603-34610	NNP	denotes	elegans
T8871	34610-34612	,	denotes	,
T8872	34612-34617	WDT	denotes	which
T8873	34618-34627	VBZ	denotes	interacts
T8874	34628-34632	IN	denotes	with
T8875	34633-34636	DT	denotes	the
T8877	34637-34642	NN	denotes	ceTAC
T8878	34643-34650	NN	denotes	binding
T8876	34651-34658	NN	denotes	protein
T8879	34659-34664	NN	denotes	lin36
T8880	34665-34666	-LRB-	denotes	(
T8881	34666-34670	NN	denotes	Fig.
T8882	34671-34673	CD	denotes	6A
T8883	34673-34674	-RRB-	denotes	)
T8884	34674-34675	.	denotes	.
T8885	34675-34940	sentence	denotes	This suggests that while protostome TACCs may require additional protein factors to interact with such components, the TACCs in higher organisms may have evolved the ability to directly interact with some of the proteins in the predicted interaction map (Fig. 6E).
T8886	34676-34680	DT	denotes	This
T8887	34681-34689	VBZ	denotes	suggests
T8888	34690-34694	IN	denotes	that
T8890	34695-34700	IN	denotes	while
T8892	34701-34711	NN	denotes	protostome
T8893	34712-34717	NNS	denotes	TACCs
T8894	34718-34721	MD	denotes	may
T8891	34722-34729	VB	denotes	require
T8895	34730-34740	JJ	denotes	additional
T8897	34741-34748	NN	denotes	protein
T8896	34749-34756	NNS	denotes	factors
T8898	34757-34759	TO	denotes	to
T8899	34760-34768	VB	denotes	interact
T8900	34769-34773	IN	denotes	with
T8901	34774-34778	JJ	denotes	such
T8902	34779-34789	NNS	denotes	components
T8903	34789-34791	,	denotes	,
T8904	34791-34794	DT	denotes	the
T8905	34795-34800	NNS	denotes	TACCs
T8906	34801-34803	IN	denotes	in
T8907	34804-34810	JJR	denotes	higher
T8908	34811-34820	NNS	denotes	organisms
T8909	34821-34824	MD	denotes	may
T8910	34825-34829	VB	denotes	have
T8889	34830-34837	VBN	denotes	evolved
T8911	34838-34841	DT	denotes	the
T8912	34842-34849	NN	denotes	ability
T8913	34850-34852	TO	denotes	to
T8915	34853-34861	RB	denotes	directly
T8914	34862-34870	VB	denotes	interact
T8916	34871-34875	IN	denotes	with
T8917	34876-34880	DT	denotes	some
T8918	34881-34883	IN	denotes	of
T8919	34884-34887	DT	denotes	the
T8920	34888-34896	NN	denotes	proteins
T8921	34897-34899	IN	denotes	in
T8922	34900-34903	DT	denotes	the
T8924	34904-34913	VBN	denotes	predicted
T8925	34914-34925	NN	denotes	interaction
T8923	34926-34929	NN	denotes	map
T8926	34930-34931	-LRB-	denotes	(
T8927	34931-34935	NN	denotes	Fig.
T8928	34936-34938	CD	denotes	6E
T8929	34938-34939	-RRB-	denotes	)
T8930	34939-34940	.	denotes	.
T8931	34940-35065	sentence	denotes	Indeed, this appears to be directly linked to the acquisition of new domains and duplication of the chordate TACC precursor.
T8932	34941-34947	RB	denotes	Indeed
T8934	34947-34949	,	denotes	,
T8935	34949-34953	DT	denotes	this
T8933	34954-34961	VBZ	denotes	appears
T8936	34962-34964	TO	denotes	to
T8938	34965-34967	VB	denotes	be
T8939	34968-34976	RB	denotes	directly
T8937	34977-34983	VBN	denotes	linked
T8940	34984-34986	IN	denotes	to
T8941	34987-34990	DT	denotes	the
T8942	34991-35002	NN	denotes	acquisition
T8943	35003-35005	IN	denotes	of
T8944	35006-35009	JJ	denotes	new
T8945	35010-35017	NNS	denotes	domains
T8946	35018-35021	CC	denotes	and
T8947	35022-35033	NN	denotes	duplication
T8948	35034-35036	IN	denotes	of
T8949	35037-35040	DT	denotes	the
T8951	35041-35049	NN	denotes	chordate
T8952	35050-35054	NN	denotes	TACC
T8950	35055-35064	NN	denotes	precursor
T8953	35064-35065	.	denotes	.
T8954	35065-35246	sentence	denotes	In fact, the first identified function of a vertebrate TACC protein was as a transcriptional coactivator acting through a direct interaction with the ARNT transcription factor [7].
T8955	35066-35068	IN	denotes	In
T8957	35069-35073	NN	denotes	fact
T8958	35073-35075	,	denotes	,
T8959	35075-35078	DT	denotes	the
T8961	35079-35084	JJ	denotes	first
T8962	35085-35095	VBN	denotes	identified
T8960	35096-35104	NN	denotes	function
T8963	35105-35107	IN	denotes	of
T8964	35108-35109	DT	denotes	a
T8966	35110-35120	NN	denotes	vertebrate
T8967	35121-35125	NN	denotes	TACC
T8965	35126-35133	NN	denotes	protein
T8956	35134-35137	VBD	denotes	was
T8968	35138-35140	IN	denotes	as
T8969	35141-35142	DT	denotes	a
T8971	35143-35158	JJ	denotes	transcriptional
T8970	35159-35170	NN	denotes	coactivator
T8972	35171-35177	VBG	denotes	acting
T8973	35178-35185	IN	denotes	through
T8974	35186-35187	DT	denotes	a
T8976	35188-35194	JJ	denotes	direct
T8975	35195-35206	NN	denotes	interaction
T8977	35207-35211	IN	denotes	with
T8978	35212-35215	DT	denotes	the
T8980	35216-35220	NN	denotes	ARNT
T8981	35221-35234	NN	denotes	transcription
T8979	35235-35241	NN	denotes	factor
T8982	35242-35243	-LRB-	denotes	[
T8983	35243-35244	CD	denotes	7
T8984	35244-35245	-RRB-	denotes	]
T8985	35245-35246	.	denotes	.
T8986	35246-35419	sentence	denotes	It is also intriguing that the deuterostome specific SDP repeat interacts with GAS41, a component/accessory factor of the human SWI/SNF chromatin remodeling complex [3,15].
T8987	35247-35249	PRP	denotes	It
T8988	35250-35252	VBZ	denotes	is
T8989	35253-35257	RB	denotes	also
T8990	35258-35268	JJ	denotes	intriguing
T8991	35269-35273	IN	denotes	that
T8993	35274-35277	DT	denotes	the
T8995	35278-35290	NN	denotes	deuterostome
T8996	35291-35299	JJ	denotes	specific
T8997	35300-35303	NN	denotes	SDP
T8994	35304-35310	NN	denotes	repeat
T8992	35311-35320	VBZ	denotes	interacts
T8998	35321-35325	IN	denotes	with
T8999	35326-35331	NN	denotes	GAS41
T9000	35331-35333	,	denotes	,
T9001	35333-35334	DT	denotes	a
T9003	35335-35344	NN	denotes	component
T9005	35344-35345	HYPH	denotes	/
T9004	35345-35354	NN	denotes	accessory
T9002	35355-35361	NN	denotes	factor
T9006	35362-35364	IN	denotes	of
T9007	35365-35368	DT	denotes	the
T9009	35369-35374	JJ	denotes	human
T9010	35375-35378	NN	denotes	SWI
T9012	35378-35379	HYPH	denotes	/
T9011	35379-35382	NN	denotes	SNF
T9013	35383-35392	NN	denotes	chromatin
T9014	35393-35403	NN	denotes	remodeling
T9008	35404-35411	NN	denotes	complex
T9015	35412-35413	-LRB-	denotes	[
T9017	35413-35414	CD	denotes	3
T9018	35414-35415	,	denotes	,
T9016	35415-35417	CD	denotes	15
T9019	35417-35418	-RRB-	denotes	]
T9020	35418-35419	.	denotes	.
T9021	35419-35593	sentence	denotes	Although there is a D. melanogaster homologue of GAS41, dmGAS41, the large scale proteomic interaction database does not indicate a direct interaction of dmGAS41 with DTACC.
T9022	35420-35428	IN	denotes	Although
T9024	35429-35434	EX	denotes	there
T9023	35435-35437	VBZ	denotes	is
T9026	35438-35439	DT	denotes	a
T9028	35440-35442	NNP	denotes	D.
T9029	35443-35455	NNP	denotes	melanogaster
T9027	35456-35465	NN	denotes	homologue
T9030	35466-35468	IN	denotes	of
T9031	35469-35474	NN	denotes	GAS41
T9032	35474-35476	,	denotes	,
T9033	35476-35483	NN	denotes	dmGAS41
T9034	35483-35485	,	denotes	,
T9035	35485-35488	DT	denotes	the
T9037	35489-35494	JJ	denotes	large
T9038	35495-35500	NN	denotes	scale
T9040	35501-35510	JJ	denotes	proteomic
T9039	35511-35522	NN	denotes	interaction
T9036	35523-35531	NN	denotes	database
T9041	35532-35536	VBZ	denotes	does
T9042	35537-35540	RB	denotes	not
T9025	35541-35549	VB	denotes	indicate
T9043	35550-35551	DT	denotes	a
T9045	35552-35558	JJ	denotes	direct
T9044	35559-35570	NN	denotes	interaction
T9046	35571-35573	IN	denotes	of
T9047	35574-35581	NN	denotes	dmGAS41
T9048	35582-35586	IN	denotes	with
T9049	35587-35592	NN	denotes	DTACC
T9050	35592-35593	.	denotes	.
T9051	35593-35678	sentence	denotes	This may be due to the lack of the SDP repeat region in the Drosophila TACC protein.
T9052	35594-35598	DT	denotes	This
T9054	35599-35602	MD	denotes	may
T9053	35603-35605	VB	denotes	be
T9055	35606-35609	IN	denotes	due
T9056	35610-35612	IN	denotes	to
T9057	35613-35616	DT	denotes	the
T9058	35617-35621	NN	denotes	lack
T9059	35622-35624	IN	denotes	of
T9060	35625-35628	DT	denotes	the
T9062	35629-35632	NN	denotes	SDP
T9063	35633-35639	NN	denotes	repeat
T9061	35640-35646	NN	denotes	region
T9064	35647-35649	IN	denotes	in
T9065	35650-35653	DT	denotes	the
T9067	35654-35664	NNP	denotes	Drosophila
T9068	35665-35669	NN	denotes	TACC
T9066	35670-35677	NN	denotes	protein
T9069	35677-35678	.	denotes	.
T9070	35678-35874	sentence	denotes	This further suggests that the vertebrate TACCs have gained the specific ability to direct interact with transcriptional regulatory complexes, and that bridging protein(s) are no longer required.
T9071	35679-35683	DT	denotes	This
T9073	35684-35691	RB	denotes	further
T9072	35692-35700	VBZ	denotes	suggests
T9074	35701-35705	IN	denotes	that
T9076	35706-35709	DT	denotes	the
T9078	35710-35720	NN	denotes	vertebrate
T9077	35721-35726	NNS	denotes	TACCs
T9079	35727-35731	VBP	denotes	have
T9075	35732-35738	VBN	denotes	gained
T9080	35739-35742	DT	denotes	the
T9082	35743-35751	JJ	denotes	specific
T9081	35752-35759	NN	denotes	ability
T9083	35760-35762	TO	denotes	to
T9085	35763-35769	JJ	denotes	direct
T9084	35770-35778	VB	denotes	interact
T9086	35779-35783	IN	denotes	with
T9087	35784-35799	JJ	denotes	transcriptional
T9089	35800-35810	JJ	denotes	regulatory
T9088	35811-35820	NNS	denotes	complexes
T9090	35820-35822	,	denotes	,
T9091	35822-35825	CC	denotes	and
T9092	35826-35830	IN	denotes	that
T9094	35831-35839	VBG	denotes	bridging
T9095	35840-35847	NN	denotes	protein
T9096	35847-35848	-LRB-	denotes	(
T9097	35848-35849	AFX	denotes	s
T9098	35849-35850	-RRB-	denotes	)
T9099	35851-35854	VBP	denotes	are
T9100	35855-35857	RB	denotes	no
T9101	35858-35864	RBR	denotes	longer
T9093	35865-35873	VBN	denotes	required
T9102	35873-35874	.	denotes	.
T9103	35874-36131	sentence	denotes	Thus, where the ceTAC protein is only composed of the TACC domain, the significantly larger TACC family members in higher protostomes and deuterostomes may have integrated one or more functions of the bridging protein (in this case lin15A, lin36 or lin37).
T9104	35875-35879	RB	denotes	Thus
T9106	35879-35881	,	denotes	,
T9107	35881-35886	WRB	denotes	where
T9109	35887-35890	DT	denotes	the
T9111	35891-35896	NN	denotes	ceTAC
T9110	35897-35904	NN	denotes	protein
T9112	35905-35907	VBZ	denotes	is
T9113	35908-35912	RB	denotes	only
T9108	35913-35921	VBN	denotes	composed
T9114	35922-35924	IN	denotes	of
T9115	35925-35928	DT	denotes	the
T9117	35929-35933	NN	denotes	TACC
T9116	35934-35940	NN	denotes	domain
T9118	35940-35942	,	denotes	,
T9119	35942-35945	DT	denotes	the
T9121	35946-35959	RB	denotes	significantly
T9122	35960-35966	JJR	denotes	larger
T9123	35967-35971	NN	denotes	TACC
T9124	35972-35978	NN	denotes	family
T9120	35979-35986	NNS	denotes	members
T9125	35987-35989	IN	denotes	in
T9126	35990-35996	JJR	denotes	higher
T9127	35997-36008	NNS	denotes	protostomes
T9128	36009-36012	CC	denotes	and
T9129	36013-36026	NNS	denotes	deuterostomes
T9130	36027-36030	MD	denotes	may
T9131	36031-36035	VB	denotes	have
T9105	36036-36046	VBN	denotes	integrated
T9132	36047-36050	CD	denotes	one
T9134	36051-36053	CC	denotes	or
T9135	36054-36058	JJR	denotes	more
T9133	36059-36068	NNS	denotes	functions
T9136	36069-36071	IN	denotes	of
T9137	36072-36075	DT	denotes	the
T9139	36076-36084	VBG	denotes	bridging
T9138	36085-36092	NN	denotes	protein
T9140	36093-36094	-LRB-	denotes	(
T9141	36094-36096	IN	denotes	in
T9142	36097-36101	DT	denotes	this
T9143	36102-36106	NN	denotes	case
T9144	36107-36113	NN	denotes	lin15A
T9145	36113-36115	,	denotes	,
T9146	36115-36120	NN	denotes	lin36
T9147	36121-36123	CC	denotes	or
T9148	36124-36129	NN	denotes	lin37
T9149	36129-36130	-RRB-	denotes	)
T9150	36130-36131	.	denotes	.
T9151	36131-36353	sentence	denotes	This may also explain the absence of lin15A, lin36 and lin37 homologues in higher organisms, as they were no longer under selective evolutionary pressure to remain within the complex, and thus lost in the evolving genome.
T9152	36132-36136	DT	denotes	This
T9154	36137-36140	MD	denotes	may
T9155	36141-36145	RB	denotes	also
T9153	36146-36153	VB	denotes	explain
T9156	36154-36157	DT	denotes	the
T9157	36158-36165	NN	denotes	absence
T9158	36166-36168	IN	denotes	of
T9159	36169-36175	NN	denotes	lin15A
T9161	36175-36177	,	denotes	,
T9162	36177-36182	NN	denotes	lin36
T9163	36183-36186	CC	denotes	and
T9164	36187-36192	NN	denotes	lin37
T9160	36193-36203	NNS	denotes	homologues
T9165	36204-36206	IN	denotes	in
T9166	36207-36213	JJR	denotes	higher
T9167	36214-36223	NNS	denotes	organisms
T9168	36223-36225	,	denotes	,
T9169	36225-36227	IN	denotes	as
T9171	36228-36232	PRP	denotes	they
T9170	36233-36237	VBD	denotes	were
T9172	36238-36240	RB	denotes	no
T9173	36241-36247	RBR	denotes	longer
T9174	36248-36253	IN	denotes	under
T9175	36254-36263	JJ	denotes	selective
T9177	36264-36276	JJ	denotes	evolutionary
T9176	36277-36285	NN	denotes	pressure
T9178	36286-36288	TO	denotes	to
T9179	36289-36295	VB	denotes	remain
T9180	36296-36302	IN	denotes	within
T9181	36303-36306	DT	denotes	the
T9182	36307-36314	NN	denotes	complex
T9183	36314-36316	,	denotes	,
T9184	36316-36319	CC	denotes	and
T9185	36320-36324	RB	denotes	thus
T9186	36325-36329	VBN	denotes	lost
T9187	36330-36332	IN	denotes	in
T9188	36333-36336	DT	denotes	the
T9190	36337-36345	VBG	denotes	evolving
T9189	36346-36352	NN	denotes	genome
T9191	36352-36353	.	denotes	.
T13875	36364-36366	FW	denotes	In
T13876	36367-36372	FW	denotes	vitro
T13877	36373-36384	NN	denotes	interaction
T13878	36385-36387	IN	denotes	of
T13879	36388-36393	NN	denotes	RXRβ3
T13880	36394-36397	CC	denotes	and
T13881	36398-36404	NNS	denotes	TACC2s
T13882	36404-36405	.	denotes	.
T13883	36405-36610	sentence	denotes	Top panel: Autoradiograph of 12% SDS polyacrylamide gel with in vitro translated RXRβ3 construct pulled down with GST-TACC2 (Lane 1) or GST (Lane 2); Lane 3: 5% input of in vitro translated RXR-β protein.
T13884	36406-36409	JJ	denotes	Top
T13885	36410-36415	NN	denotes	panel
T13887	36415-36417	:	denotes	:
T13886	36417-36431	NN	denotes	Autoradiograph
T13889	36432-36434	IN	denotes	of
T13890	36435-36437	CD	denotes	12
T13891	36437-36438	NN	denotes	%
T13892	36439-36442	NN	denotes	SDS
T13894	36443-36457	NN	denotes	polyacrylamide
T13893	36458-36461	NN	denotes	gel
T13895	36462-36466	IN	denotes	with
T13896	36467-36469	FW	denotes	in
T13897	36470-36475	FW	denotes	vitro
T13898	36476-36486	VBN	denotes	translated
T13900	36487-36492	NN	denotes	RXRβ3
T13899	36493-36502	NN	denotes	construct
T13901	36503-36509	VBN	denotes	pulled
T13902	36510-36514	RP	denotes	down
T13903	36515-36519	IN	denotes	with
T13904	36520-36523	NN	denotes	GST
T13906	36523-36524	HYPH	denotes	-
T13905	36524-36529	NN	denotes	TACC2
T13907	36530-36531	-LRB-	denotes	(
T13908	36531-36535	NN	denotes	Lane
T13909	36536-36537	CD	denotes	1
T13910	36537-36538	-RRB-	denotes	)
T13911	36539-36541	CC	denotes	or
T13912	36542-36545	NN	denotes	GST
T13913	36546-36547	-LRB-	denotes	(
T13914	36547-36551	NN	denotes	Lane
T13915	36552-36553	CD	denotes	2
T13916	36553-36554	-RRB-	denotes	)
T13917	36554-36555	:	denotes	;
T13918	36556-36560	NN	denotes	Lane
T13919	36561-36562	CD	denotes	3
T13920	36562-36564	SYM	denotes	:
T13921	36564-36565	CD	denotes	5
T13922	36565-36566	NN	denotes	%
T13888	36567-36572	NN	denotes	input
T13923	36573-36575	IN	denotes	of
T13924	36576-36578	FW	denotes	in
T13925	36579-36584	FW	denotes	vitro
T13927	36585-36595	VBN	denotes	translated
T13928	36596-36599	NN	denotes	RXR
T13930	36599-36600	HYPH	denotes	-
T13929	36600-36601	NN	denotes	β
T13926	36602-36609	NN	denotes	protein
T13931	36609-36610	.	denotes	.
T13932	36610-36728	sentence	denotes	Bottom two panels represent Coomassie blue stained gels of pull down experiment showing loading of GST-TACC2 and GST.
T13933	36611-36617	JJ	denotes	Bottom
T13935	36618-36621	CD	denotes	two
T13934	36622-36628	NNS	denotes	panels
T13936	36629-36638	VBP	denotes	represent
T13937	36639-36648	NNP	denotes	Coomassie
T13939	36649-36653	JJ	denotes	blue
T13940	36654-36661	VBN	denotes	stained
T13938	36662-36666	NNS	denotes	gels
T13941	36667-36669	IN	denotes	of
T13942	36670-36674	VB	denotes	pull
T13944	36675-36679	RP	denotes	down
T13943	36680-36690	NN	denotes	experiment
T13945	36691-36698	VBG	denotes	showing
T13946	36699-36706	NN	denotes	loading
T13947	36707-36709	IN	denotes	of
T13948	36710-36713	NN	denotes	GST
T13950	36713-36714	HYPH	denotes	-
T13949	36714-36719	NN	denotes	TACC2
T13951	36720-36723	CC	denotes	and
T13952	36724-36727	NN	denotes	GST
T13953	36727-36728	.	denotes	.
T9492	36742-36750	VBN	denotes	Proposed
T9494	36751-36761	JJ	denotes	functional
T9493	36762-36771	NN	denotes	evolution
T9495	36772-36774	IN	denotes	of
T9496	36775-36778	DT	denotes	the
T9498	36779-36783	NN	denotes	TACC
T9497	36784-36790	NN	denotes	family
T9499	36790-36909	sentence	denotes	Examination of the evolution of ancient gene families provides an insight into how gene structure relates to function.
T9500	36791-36802	NN	denotes	Examination
T9502	36803-36805	IN	denotes	of
T9503	36806-36809	DT	denotes	the
T9504	36810-36819	NN	denotes	evolution
T9505	36820-36822	IN	denotes	of
T9506	36823-36830	JJ	denotes	ancient
T9508	36831-36835	NN	denotes	gene
T9507	36836-36844	NNS	denotes	families
T9501	36845-36853	VBZ	denotes	provides
T9509	36854-36856	DT	denotes	an
T9510	36857-36864	NN	denotes	insight
T9511	36865-36869	IN	denotes	into
T9512	36870-36873	WRB	denotes	how
T9514	36874-36878	NN	denotes	gene
T9515	36879-36888	NN	denotes	structure
T9513	36889-36896	VBZ	denotes	relates
T9516	36897-36899	IN	denotes	to
T9517	36900-36908	NN	denotes	function
T9518	36908-36909	.	denotes	.
T9519	36909-36982	sentence	denotes	We have presented above, a detailed examination of one such gene family.
T9520	36910-36912	PRP	denotes	We
T9522	36913-36917	VBP	denotes	have
T9521	36918-36927	VBN	denotes	presented
T9523	36928-36933	RB	denotes	above
T9524	36933-36935	,	denotes	,
T9525	36935-36936	DT	denotes	a
T9527	36937-36945	JJ	denotes	detailed
T9526	36946-36957	NN	denotes	examination
T9528	36958-36960	IN	denotes	of
T9529	36961-36964	CD	denotes	one
T9531	36965-36969	JJ	denotes	such
T9532	36970-36974	NN	denotes	gene
T9530	36975-36981	NN	denotes	family
T9533	36981-36982	.	denotes	.
T9534	36982-37127	sentence	denotes	The data so far suggest that the functional TACC homologue in yeast (spc72) has a specific role in centrosomal/mitotic spindle dynamics [21,22].
T9535	36983-36986	DT	denotes	The
T9536	36987-36991	NNS	denotes	data
T9538	36992-36994	RB	denotes	so
T9539	36995-36998	RB	denotes	far
T9537	36999-37006	VBP	denotes	suggest
T9540	37007-37011	IN	denotes	that
T9542	37012-37015	DT	denotes	the
T9544	37016-37026	JJ	denotes	functional
T9545	37027-37031	NN	denotes	TACC
T9543	37032-37041	NN	denotes	homologue
T9546	37042-37044	IN	denotes	in
T9547	37045-37050	NN	denotes	yeast
T9548	37051-37052	-LRB-	denotes	(
T9549	37052-37057	NN	denotes	spc72
T9550	37057-37058	-RRB-	denotes	)
T9541	37059-37062	VBZ	denotes	has
T9551	37063-37064	DT	denotes	a
T9553	37065-37073	JJ	denotes	specific
T9552	37074-37078	NN	denotes	role
T9554	37079-37081	IN	denotes	in
T9555	37082-37093	JJ	denotes	centrosomal
T9557	37093-37094	HYPH	denotes	/
T9556	37094-37101	JJ	denotes	mitotic
T9558	37102-37109	NN	denotes	spindle
T9559	37110-37118	NNS	denotes	dynamics
T9560	37119-37120	-LRB-	denotes	[
T9562	37120-37122	CD	denotes	21
T9563	37122-37123	,	denotes	,
T9561	37123-37125	CD	denotes	22
T9564	37125-37126	-RRB-	denotes	]
T9565	37126-37127	.	denotes	.
T9566	37127-37227	sentence	denotes	This ancient TACC function is conserved throughout evolution in both protostomes and deuterostomes.
T9567	37128-37132	DT	denotes	This
T9569	37133-37140	JJ	denotes	ancient
T9570	37141-37145	NN	denotes	TACC
T9568	37146-37154	NN	denotes	function
T9572	37155-37157	VBZ	denotes	is
T9571	37158-37167	VBN	denotes	conserved
T9573	37168-37178	IN	denotes	throughout
T9574	37179-37188	NN	denotes	evolution
T9575	37189-37191	IN	denotes	in
T9576	37192-37196	CC	denotes	both
T9577	37197-37208	NNS	denotes	protostomes
T9578	37209-37212	CC	denotes	and
T9579	37213-37226	NNS	denotes	deuterostomes
T9580	37226-37227	.	denotes	.
T9581	37227-37464	sentence	denotes	In addition, the TACC proteins of lower organisms appear to interact with bridging proteins that are components of several different protein complexes involved in DNA damage repair, protein translation, RNA processing and transcription.
T9582	37228-37230	IN	denotes	In
T9584	37231-37239	NN	denotes	addition
T9585	37239-37241	,	denotes	,
T9586	37241-37244	DT	denotes	the
T9588	37245-37249	NN	denotes	TACC
T9587	37250-37258	NN	denotes	proteins
T9589	37259-37261	IN	denotes	of
T9590	37262-37267	JJR	denotes	lower
T9591	37268-37277	NNS	denotes	organisms
T9583	37278-37284	VBP	denotes	appear
T9592	37285-37287	TO	denotes	to
T9593	37288-37296	VB	denotes	interact
T9594	37297-37301	IN	denotes	with
T9595	37302-37310	NN	denotes	bridging
T9596	37311-37319	NN	denotes	proteins
T9597	37320-37324	WDT	denotes	that
T9598	37325-37328	VBP	denotes	are
T9599	37329-37339	NNS	denotes	components
T9600	37340-37342	IN	denotes	of
T9601	37343-37350	JJ	denotes	several
T9603	37351-37360	JJ	denotes	different
T9604	37361-37368	NN	denotes	protein
T9602	37369-37378	NNS	denotes	complexes
T9605	37379-37387	VBN	denotes	involved
T9606	37388-37390	IN	denotes	in
T9607	37391-37394	NN	denotes	DNA
T9608	37395-37401	NN	denotes	damage
T9609	37402-37408	NN	denotes	repair
T9610	37408-37410	,	denotes	,
T9611	37410-37417	NN	denotes	protein
T9612	37418-37429	NN	denotes	translation
T9613	37429-37431	,	denotes	,
T9614	37431-37434	NN	denotes	RNA
T9615	37435-37445	NN	denotes	processing
T9616	37446-37449	CC	denotes	and
T9617	37450-37463	NN	denotes	transcription
T9618	37463-37464	.	denotes	.
T9619	37464-37893	sentence	denotes	However, over the process of evolutionary time, with the acquisition of new domains and duplication of the chordate TACC precursor, the chordate TACC proteins have acquired the ability to directly interact with some of the other components of these complexes (such as the LSm proteins, nuclear hormone receptors, GAS41, accessory proteins and transcription factors), and thus evolved additional functions within these complexes.
T9620	37465-37472	RB	denotes	However
T9622	37472-37474	,	denotes	,
T9623	37474-37478	IN	denotes	over
T9624	37479-37482	DT	denotes	the
T9625	37483-37490	NN	denotes	process
T9626	37491-37493	IN	denotes	of
T9627	37494-37506	JJ	denotes	evolutionary
T9628	37507-37511	NN	denotes	time
T9629	37511-37513	,	denotes	,
T9630	37513-37517	IN	denotes	with
T9631	37518-37521	DT	denotes	the
T9632	37522-37533	NN	denotes	acquisition
T9633	37534-37536	IN	denotes	of
T9634	37537-37540	JJ	denotes	new
T9635	37541-37548	NNS	denotes	domains
T9636	37549-37552	CC	denotes	and
T9637	37553-37564	NN	denotes	duplication
T9638	37565-37567	IN	denotes	of
T9639	37568-37571	DT	denotes	the
T9641	37572-37580	NN	denotes	chordate
T9642	37581-37585	NN	denotes	TACC
T9640	37586-37595	NN	denotes	precursor
T9643	37595-37597	,	denotes	,
T9644	37597-37600	DT	denotes	the
T9646	37601-37609	NN	denotes	chordate
T9647	37610-37614	NN	denotes	TACC
T9645	37615-37623	NN	denotes	proteins
T9648	37624-37628	VBP	denotes	have
T9621	37629-37637	VBN	denotes	acquired
T9649	37638-37641	DT	denotes	the
T9650	37642-37649	NN	denotes	ability
T9651	37650-37652	TO	denotes	to
T9653	37653-37661	RB	denotes	directly
T9652	37662-37670	VB	denotes	interact
T9654	37671-37675	IN	denotes	with
T9655	37676-37680	DT	denotes	some
T9656	37681-37683	IN	denotes	of
T9657	37684-37687	DT	denotes	the
T9659	37688-37693	JJ	denotes	other
T9658	37694-37704	NNS	denotes	components
T9660	37705-37707	IN	denotes	of
T9661	37708-37713	DT	denotes	these
T9662	37714-37723	NNS	denotes	complexes
T9663	37724-37725	-LRB-	denotes	(
T9664	37725-37729	JJ	denotes	such
T9665	37730-37732	IN	denotes	as
T9666	37733-37736	DT	denotes	the
T9668	37737-37740	NN	denotes	LSm
T9667	37741-37749	NN	denotes	proteins
T9669	37749-37751	,	denotes	,
T9670	37751-37758	JJ	denotes	nuclear
T9672	37759-37766	NN	denotes	hormone
T9671	37767-37776	NNS	denotes	receptors
T9673	37776-37778	,	denotes	,
T9674	37778-37783	NN	denotes	GAS41
T9675	37783-37785	,	denotes	,
T9676	37785-37794	JJ	denotes	accessory
T9677	37795-37803	NN	denotes	proteins
T9678	37804-37807	CC	denotes	and
T9679	37808-37821	NN	denotes	transcription
T9680	37822-37829	NNS	denotes	factors
T9681	37829-37830	-RRB-	denotes	)
T9682	37830-37832	,	denotes	,
T9683	37832-37835	CC	denotes	and
T9684	37836-37840	RB	denotes	thus
T9685	37841-37848	VBD	denotes	evolved
T9686	37849-37859	JJ	denotes	additional
T9687	37860-37869	NNS	denotes	functions
T9688	37870-37876	IN	denotes	within
T9689	37877-37882	DT	denotes	these
T9690	37883-37892	NNS	denotes	complexes
T9691	37892-37893	.	denotes	.
T9692	37893-38101	sentence	denotes	Indeed, the first assigned function of a vertebrate TACC protein, mouse TACC3, was as a transcriptional coactivator of the ARNT mediated transcriptional response to hypoxia and polyaromatic hydrocarbons [7].
T9693	37894-37900	RB	denotes	Indeed
T9695	37900-37902	,	denotes	,
T9696	37902-37905	DT	denotes	the
T9698	37906-37911	JJ	denotes	first
T9699	37912-37920	VBN	denotes	assigned
T9697	37921-37929	NN	denotes	function
T9700	37930-37932	IN	denotes	of
T9701	37933-37934	DT	denotes	a
T9703	37935-37945	NN	denotes	vertebrate
T9704	37946-37950	NN	denotes	TACC
T9702	37951-37958	NN	denotes	protein
T9705	37958-37960	,	denotes	,
T9706	37960-37965	NN	denotes	mouse
T9707	37966-37971	NN	denotes	TACC3
T9708	37971-37973	,	denotes	,
T9694	37973-37976	VBD	denotes	was
T9709	37977-37979	IN	denotes	as
T9710	37980-37981	DT	denotes	a
T9712	37982-37997	JJ	denotes	transcriptional
T9711	37998-38009	NN	denotes	coactivator
T9713	38010-38012	IN	denotes	of
T9714	38013-38016	DT	denotes	the
T9716	38017-38021	NN	denotes	ARNT
T9717	38022-38030	VBN	denotes	mediated
T9718	38031-38046	JJ	denotes	transcriptional
T9715	38047-38055	NN	denotes	response
T9719	38056-38058	IN	denotes	to
T9720	38059-38066	NN	denotes	hypoxia
T9721	38067-38070	CC	denotes	and
T9722	38071-38083	JJ	denotes	polyaromatic
T9723	38084-38096	NNS	denotes	hydrocarbons
T9724	38097-38098	-LRB-	denotes	[
T9725	38098-38099	CD	denotes	7
T9726	38099-38100	-RRB-	denotes	]
T9727	38100-38101	.	denotes	.
T9728	38101-38190	sentence	denotes	Mouse TACC3 has also been reported to interact with the transcription factor STAT5 [33].
T9729	38102-38107	NN	denotes	Mouse
T9730	38108-38113	NN	denotes	TACC3
T9732	38114-38117	VBZ	denotes	has
T9733	38118-38122	RB	denotes	also
T9734	38123-38127	VBN	denotes	been
T9731	38128-38136	VBN	denotes	reported
T9735	38137-38139	TO	denotes	to
T9736	38140-38148	VB	denotes	interact
T9737	38149-38153	IN	denotes	with
T9738	38154-38157	DT	denotes	the
T9740	38158-38171	NN	denotes	transcription
T9741	38172-38178	NN	denotes	factor
T9739	38179-38184	NN	denotes	STAT5
T9742	38185-38186	-LRB-	denotes	[
T9743	38186-38188	CD	denotes	33
T9744	38188-38189	-RRB-	denotes	]
T9745	38189-38190	.	denotes	.
T9746	38190-38407	sentence	denotes	Recently, we have demonstrated that TACC2 and TACC3 can bind to nuclear histone acetyltransferases [34], further confirming a more direct role for the TACC proteins in transcriptional and chromatin remodeling events.
T9747	38191-38199	RB	denotes	Recently
T9749	38199-38201	,	denotes	,
T9750	38201-38203	PRP	denotes	we
T9751	38204-38208	VBP	denotes	have
T9748	38209-38221	VBN	denotes	demonstrated
T9752	38222-38226	IN	denotes	that
T9754	38227-38232	NN	denotes	TACC2
T9755	38233-38236	CC	denotes	and
T9756	38237-38242	NN	denotes	TACC3
T9757	38243-38246	MD	denotes	can
T9753	38247-38251	VB	denotes	bind
T9758	38252-38254	IN	denotes	to
T9759	38255-38262	JJ	denotes	nuclear
T9761	38263-38270	NN	denotes	histone
T9760	38271-38289	NNS	denotes	acetyltransferases
T9762	38290-38291	-LRB-	denotes	[
T9763	38291-38293	CD	denotes	34
T9764	38293-38294	-RRB-	denotes	]
T9765	38294-38296	,	denotes	,
T9766	38296-38303	RB	denotes	further
T9767	38304-38314	VBG	denotes	confirming
T9768	38315-38316	DT	denotes	a
T9770	38317-38321	RBR	denotes	more
T9771	38322-38328	JJ	denotes	direct
T9769	38329-38333	NN	denotes	role
T9772	38334-38337	IN	denotes	for
T9773	38338-38341	DT	denotes	the
T9775	38342-38346	NN	denotes	TACC
T9774	38347-38355	NN	denotes	proteins
T9776	38356-38358	IN	denotes	in
T9777	38359-38374	JJ	denotes	transcriptional
T9779	38375-38378	CC	denotes	and
T9780	38379-38388	NN	denotes	chromatin
T9781	38389-38399	NN	denotes	remodeling
T9778	38400-38406	NNS	denotes	events
T9782	38406-38407	.	denotes	.
T9783	38407-38634	sentence	denotes	Interestingly although all human TACC proteins can directly interact with the histone acetyltransferase pCAF in vitro, the TACC1 isoforms expressed in human breast cancer cells do not interact with this histone acetylase [34].
T9784	38408-38421	RB	denotes	Interestingly
T9786	38422-38430	IN	denotes	although
T9788	38431-38434	DT	denotes	all
T9790	38435-38440	JJ	denotes	human
T9791	38441-38445	NN	denotes	TACC
T9789	38446-38454	NN	denotes	proteins
T9792	38455-38458	MD	denotes	can
T9793	38459-38467	RB	denotes	directly
T9787	38468-38476	VB	denotes	interact
T9794	38477-38481	IN	denotes	with
T9795	38482-38485	DT	denotes	the
T9797	38486-38493	NN	denotes	histone
T9796	38494-38511	NN	denotes	acetyltransferase
T9798	38512-38516	NN	denotes	pCAF
T9799	38517-38519	FW	denotes	in
T9800	38520-38525	FW	denotes	vitro
T9801	38525-38527	,	denotes	,
T9802	38527-38530	DT	denotes	the
T9804	38531-38536	NN	denotes	TACC1
T9803	38537-38545	NNS	denotes	isoforms
T9805	38546-38555	VBN	denotes	expressed
T9806	38556-38558	IN	denotes	in
T9807	38559-38564	JJ	denotes	human
T9809	38565-38571	NN	denotes	breast
T9810	38572-38578	NN	denotes	cancer
T9808	38579-38584	NNS	denotes	cells
T9811	38585-38587	VBP	denotes	do
T9812	38588-38591	RB	denotes	not
T9785	38592-38600	VB	denotes	interact
T9813	38601-38605	IN	denotes	with
T9814	38606-38610	DT	denotes	this
T9816	38611-38618	NN	denotes	histone
T9815	38619-38628	NN	denotes	acetylase
T9817	38629-38630	-LRB-	denotes	[
T9818	38630-38632	CD	denotes	34
T9819	38632-38633	-RRB-	denotes	]
T9820	38633-38634	.	denotes	.
T9821	38634-38788	sentence	denotes	This may be attributable to the proposed function of the Exon 1 containing TACC1 variants in RNA processing, via the interaction with LSm-7 and SmG [19].
T9822	38635-38639	DT	denotes	This
T9824	38640-38643	MD	denotes	may
T9823	38644-38646	VB	denotes	be
T9825	38647-38659	JJ	denotes	attributable
T9826	38660-38662	IN	denotes	to
T9827	38663-38666	DT	denotes	the
T9829	38667-38675	VBN	denotes	proposed
T9828	38676-38684	NN	denotes	function
T9830	38685-38687	IN	denotes	of
T9831	38688-38691	DT	denotes	the
T9833	38692-38696	NN	denotes	Exon
T9835	38697-38698	CD	denotes	1
T9834	38699-38709	VBG	denotes	containing
T9836	38710-38715	NN	denotes	TACC1
T9832	38716-38724	NNS	denotes	variants
T9837	38725-38727	IN	denotes	in
T9838	38728-38731	NN	denotes	RNA
T9839	38732-38742	NN	denotes	processing
T9840	38742-38744	,	denotes	,
T9841	38744-38747	IN	denotes	via
T9842	38748-38751	DT	denotes	the
T9843	38752-38763	NN	denotes	interaction
T9844	38764-38768	IN	denotes	with
T9845	38769-38772	NN	denotes	LSm
T9846	38772-38773	HYPH	denotes	-
T9847	38773-38774	CD	denotes	7
T9848	38775-38778	CC	denotes	and
T9849	38779-38782	NN	denotes	SmG
T9850	38783-38784	-LRB-	denotes	[
T9851	38784-38786	CD	denotes	19
T9852	38786-38787	-RRB-	denotes	]
T9853	38787-38788	.	denotes	.
T9854	38788-39115	sentence	denotes	Thus, alternative splicing of the TACC1 gene adds further diversity to TACC1 function, as the deletion of specific exons and their associated binding domains will change the potential protein complexes with which they can associate, either directly, or by redirecting the splice variants to different subcellular compartments.
T9855	38789-38793	RB	denotes	Thus
T9857	38793-38795	,	denotes	,
T9858	38795-38806	JJ	denotes	alternative
T9859	38807-38815	NN	denotes	splicing
T9860	38816-38818	IN	denotes	of
T9861	38819-38822	DT	denotes	the
T9863	38823-38828	NN	denotes	TACC1
T9862	38829-38833	NN	denotes	gene
T9856	38834-38838	VBZ	denotes	adds
T9864	38839-38846	JJ	denotes	further
T9865	38847-38856	NN	denotes	diversity
T9866	38857-38859	IN	denotes	to
T9867	38860-38865	NN	denotes	TACC1
T9868	38866-38874	NN	denotes	function
T9869	38874-38876	,	denotes	,
T9870	38876-38878	IN	denotes	as
T9872	38879-38882	DT	denotes	the
T9873	38883-38891	NN	denotes	deletion
T9874	38892-38894	IN	denotes	of
T9875	38895-38903	JJ	denotes	specific
T9876	38904-38909	NNS	denotes	exons
T9877	38910-38913	CC	denotes	and
T9878	38914-38919	PRP$	denotes	their
T9880	38920-38930	VBN	denotes	associated
T9881	38931-38938	NN	denotes	binding
T9879	38939-38946	NNS	denotes	domains
T9882	38947-38951	MD	denotes	will
T9871	38952-38958	VB	denotes	change
T9883	38959-38962	DT	denotes	the
T9885	38963-38972	JJ	denotes	potential
T9886	38973-38980	NN	denotes	protein
T9884	38981-38990	NNS	denotes	complexes
T9887	38991-38995	IN	denotes	with
T9889	38996-39001	WDT	denotes	which
T9890	39002-39006	PRP	denotes	they
T9891	39007-39010	MD	denotes	can
T9888	39011-39020	VB	denotes	associate
T9892	39020-39022	,	denotes	,
T9893	39022-39028	CC	denotes	either
T9895	39029-39037	RB	denotes	directly
T9896	39037-39039	,	denotes	,
T9897	39039-39041	CC	denotes	or
T9894	39042-39044	IN	denotes	by
T9898	39045-39056	VBG	denotes	redirecting
T9899	39057-39060	DT	denotes	the
T9901	39061-39067	NN	denotes	splice
T9900	39068-39076	NNS	denotes	variants
T9902	39077-39079	IN	denotes	to
T9903	39080-39089	JJ	denotes	different
T9905	39090-39101	JJ	denotes	subcellular
T9904	39102-39114	NNS	denotes	compartments
T9906	39114-39115	.	denotes	.
T9907	39115-39269	sentence	denotes	With the duplication of the TACC1/TACC2 ancestor, it is apparent that an even greater functional diversity may have been introduced into the TACC family.
T9908	39116-39120	IN	denotes	With
T9910	39121-39124	DT	denotes	the
T9911	39125-39136	NN	denotes	duplication
T9912	39137-39139	IN	denotes	of
T9913	39140-39143	DT	denotes	the
T9915	39144-39149	NN	denotes	TACC1
T9917	39149-39150	HYPH	denotes	/
T9916	39150-39155	NN	denotes	TACC2
T9914	39156-39164	NN	denotes	ancestor
T9918	39164-39166	,	denotes	,
T9919	39166-39168	PRP	denotes	it
T9909	39169-39171	VBZ	denotes	is
T9920	39172-39180	JJ	denotes	apparent
T9921	39181-39185	IN	denotes	that
T9923	39186-39188	DT	denotes	an
T9925	39189-39193	RB	denotes	even
T9926	39194-39201	JJR	denotes	greater
T9927	39202-39212	JJ	denotes	functional
T9924	39213-39222	NN	denotes	diversity
T9928	39223-39226	MD	denotes	may
T9929	39227-39231	VB	denotes	have
T9930	39232-39236	VBN	denotes	been
T9922	39237-39247	VBN	denotes	introduced
T9931	39248-39252	IN	denotes	into
T9932	39253-39256	DT	denotes	the
T9934	39257-39261	NN	denotes	TACC
T9933	39262-39268	NN	denotes	family
T9935	39268-39269	.	denotes	.
T9936	39269-39437	sentence	denotes	The TACC2 protein retains the ability of TACC3 to interact with GAS41, INI1, histone acetyltransferases and transcription factors (in this case, RXRβ) (Fig. 7) [3,34].
T9937	39270-39273	DT	denotes	The
T9939	39274-39279	NN	denotes	TACC2
T9938	39280-39287	NN	denotes	protein
T9940	39288-39295	VBZ	denotes	retains
T9941	39296-39299	DT	denotes	the
T9942	39300-39307	NN	denotes	ability
T9943	39308-39310	IN	denotes	of
T9944	39311-39316	NN	denotes	TACC3
T9945	39317-39319	TO	denotes	to
T9946	39320-39328	VB	denotes	interact
T9947	39329-39333	IN	denotes	with
T9948	39334-39339	NN	denotes	GAS41
T9949	39339-39341	,	denotes	,
T9950	39341-39345	NN	denotes	INI1
T9951	39345-39347	,	denotes	,
T9952	39347-39354	NN	denotes	histone
T9953	39355-39373	NNS	denotes	acetyltransferases
T9954	39374-39377	CC	denotes	and
T9955	39378-39391	NN	denotes	transcription
T9956	39392-39399	NNS	denotes	factors
T9957	39400-39401	-LRB-	denotes	(
T9958	39401-39403	IN	denotes	in
T9960	39404-39408	DT	denotes	this
T9961	39409-39413	NN	denotes	case
T9962	39413-39415	,	denotes	,
T9959	39415-39419	NN	denotes	RXRβ
T9963	39419-39420	-RRB-	denotes	)
T9964	39421-39422	-LRB-	denotes	(
T9965	39422-39426	NN	denotes	Fig.
T9966	39427-39428	CD	denotes	7
T9967	39428-39429	-RRB-	denotes	)
T9968	39430-39431	-LRB-	denotes	[
T9970	39431-39432	CD	denotes	3
T9971	39432-39433	,	denotes	,
T9969	39433-39435	CD	denotes	34
T9972	39435-39436	-RRB-	denotes	]
T9973	39436-39437	.	denotes	.
T9974	39437-39619	sentence	denotes	However, the tissue specific splicing of the 5 kb exon in the TACC2l isoform [3] indicates that this protein has several temporal and tissue specific functions yet to be identified.
T9975	39438-39445	RB	denotes	However
T9977	39445-39447	,	denotes	,
T9978	39447-39450	DT	denotes	the
T9980	39451-39457	NN	denotes	tissue
T9981	39458-39466	JJ	denotes	specific
T9979	39467-39475	NN	denotes	splicing
T9982	39476-39478	IN	denotes	of
T9983	39479-39482	DT	denotes	the
T9985	39483-39484	CD	denotes	5
T9986	39485-39487	NN	denotes	kb
T9984	39488-39492	NN	denotes	exon
T9987	39493-39495	IN	denotes	in
T9988	39496-39499	DT	denotes	the
T9990	39500-39506	NN	denotes	TACC2l
T9989	39507-39514	NN	denotes	isoform
T9991	39515-39516	-LRB-	denotes	[
T9992	39516-39517	CD	denotes	3
T9993	39517-39518	-RRB-	denotes	]
T9976	39519-39528	VBZ	denotes	indicates
T9994	39529-39533	IN	denotes	that
T9996	39534-39538	DT	denotes	this
T9997	39539-39546	NN	denotes	protein
T9995	39547-39550	VBZ	denotes	has
T9998	39551-39558	JJ	denotes	several
T10000	39559-39567	JJ	denotes	temporal
T10001	39568-39571	CC	denotes	and
T10002	39572-39578	NN	denotes	tissue
T10003	39579-39587	JJ	denotes	specific
T9999	39588-39597	NNS	denotes	functions
T10004	39598-39601	RB	denotes	yet
T10006	39602-39604	TO	denotes	to
T10007	39605-39607	VB	denotes	be
T10005	39608-39618	VBN	denotes	identified
T10008	39618-39619	.	denotes	.
T10098	39630-39641	NN	denotes	Compilation
T10099	39642-39645	CC	denotes	and
T10100	39646-39654	NN	denotes	assembly
T10101	39655-39657	IN	denotes	of
T10102	39658-39668	RB	denotes	previously
T10103	39669-39684	JJ	denotes	uncharacterized
T10105	39685-39689	NN	denotes	TACC
T10104	39690-39695	NNS	denotes	cDNAs
T10106	39696-39699	CC	denotes	and
T10107	39700-39705	NNS	denotes	genes
T10108	39705-39903	sentence	denotes	Corresponding orthologous sequences for TACC, RHAMM, KLP, KIF, TPM and keratins families were identified initially using the TBLASTN program [36] to search the published genomic and cDNA databases.
T10109	39706-39719	VBG	denotes	Corresponding
T10111	39720-39731	JJ	denotes	orthologous
T10110	39732-39741	NNS	denotes	sequences
T10113	39742-39745	IN	denotes	for
T10114	39746-39750	NN	denotes	TACC
T10116	39750-39752	,	denotes	,
T10117	39752-39757	NN	denotes	RHAMM
T10118	39757-39759	,	denotes	,
T10119	39759-39762	NN	denotes	KLP
T10120	39762-39764	,	denotes	,
T10121	39764-39767	NN	denotes	KIF
T10122	39767-39769	,	denotes	,
T10123	39769-39772	NN	denotes	TPM
T10124	39773-39776	CC	denotes	and
T10125	39777-39785	NNS	denotes	keratins
T10115	39786-39794	NNS	denotes	families
T10126	39795-39799	VBD	denotes	were
T10112	39800-39810	VBN	denotes	identified
T10127	39811-39820	RB	denotes	initially
T10128	39821-39826	VBG	denotes	using
T10129	39827-39830	DT	denotes	the
T10131	39831-39838	NNP	denotes	TBLASTN
T10130	39839-39846	NN	denotes	program
T10132	39847-39848	-LRB-	denotes	[
T10133	39848-39850	CD	denotes	36
T10134	39850-39851	-RRB-	denotes	]
T10135	39852-39854	TO	denotes	to
T10136	39855-39861	VB	denotes	search
T10137	39862-39865	DT	denotes	the
T10139	39866-39875	VBN	denotes	published
T10140	39876-39883	JJ	denotes	genomic
T10141	39884-39887	CC	denotes	and
T10142	39888-39892	NN	denotes	cDNA
T10138	39893-39902	NNS	denotes	databases
T10143	39902-39903	.	denotes	.
T10144	39903-40023	sentence	denotes	For Takifugu rubripes, gene predictions were produced by the Ensembl automated pipeline [37] and the JGI blast server .
T10145	39904-39907	IN	denotes	For
T10147	39908-39916	NNP	denotes	Takifugu
T10148	39917-39925	NNP	denotes	rubripes
T10149	39925-39927	,	denotes	,
T10150	39927-39931	NN	denotes	gene
T10151	39932-39943	NNS	denotes	predictions
T10152	39944-39948	VBD	denotes	were
T10146	39949-39957	VBN	denotes	produced
T10153	39958-39960	IN	denotes	by
T10154	39961-39964	DT	denotes	the
T10156	39965-39972	NNP	denotes	Ensembl
T10157	39973-39982	VBN	denotes	automated
T10155	39983-39991	NN	denotes	pipeline
T10158	39992-39993	-LRB-	denotes	[
T10159	39993-39995	CD	denotes	37
T10160	39995-39996	-RRB-	denotes	]
T10161	39997-40000	CC	denotes	and
T10162	40001-40004	DT	denotes	the
T10164	40005-40008	NN	denotes	JGI
T10165	40009-40014	NN	denotes	blast
T10163	40015-40021	NN	denotes	server
T10166	40022-40023	.	denotes	.
T10167	40023-40133	sentence	denotes	DNA sequences covering the homology regions were extracted and analyzed by Genscan to obtain potential exons.
T10168	40024-40027	NN	denotes	DNA
T10169	40028-40037	NNS	denotes	sequences
T10171	40038-40046	VBG	denotes	covering
T10172	40047-40050	DT	denotes	the
T10174	40051-40059	NN	denotes	homology
T10173	40060-40067	NNS	denotes	regions
T10175	40068-40072	VBD	denotes	were
T10170	40073-40082	VBN	denotes	extracted
T10176	40083-40086	CC	denotes	and
T10177	40087-40095	VBN	denotes	analyzed
T10178	40096-40098	IN	denotes	by
T10179	40099-40106	NNP	denotes	Genscan
T10180	40107-40109	TO	denotes	to
T10181	40110-40116	VB	denotes	obtain
T10182	40117-40126	JJ	denotes	potential
T10183	40127-40132	NNS	denotes	exons
T10184	40132-40133	.	denotes	.
T10185	40133-40276	sentence	denotes	In some cases, exons were added or modified based on the best similarity of translated peptides to the corresponding mouse and human proteins.
T10186	40134-40136	IN	denotes	In
T10188	40137-40141	DT	denotes	some
T10189	40142-40147	NNS	denotes	cases
T10190	40147-40149	,	denotes	,
T10191	40149-40154	NNS	denotes	exons
T10192	40155-40159	VBD	denotes	were
T10187	40160-40165	VBN	denotes	added
T10193	40166-40168	CC	denotes	or
T10194	40169-40177	VBN	denotes	modified
T10195	40178-40183	VBN	denotes	based
T10196	40184-40186	IN	denotes	on
T10197	40187-40190	DT	denotes	the
T10199	40191-40195	JJS	denotes	best
T10198	40196-40206	NN	denotes	similarity
T10200	40207-40209	IN	denotes	of
T10201	40210-40220	VBN	denotes	translated
T10202	40221-40229	NNS	denotes	peptides
T10203	40230-40232	IN	denotes	to
T10204	40233-40236	DT	denotes	the
T10206	40237-40250	VBG	denotes	corresponding
T10207	40251-40256	NN	denotes	mouse
T10208	40257-40260	CC	denotes	and
T10209	40261-40266	JJ	denotes	human
T10205	40267-40275	NN	denotes	proteins
T10210	40275-40276	.	denotes	.
T10211	40276-40454	sentence	denotes	For regions with low sequence similarity, genomic sequences from the fresh water pufferfish, Tetraodon nigroviridis were used as additional means to verify the predicted exons.
T10212	40277-40280	IN	denotes	For
T10214	40281-40288	NNS	denotes	regions
T10215	40289-40293	IN	denotes	with
T10216	40294-40297	JJ	denotes	low
T10218	40298-40306	NN	denotes	sequence
T10217	40307-40317	NN	denotes	similarity
T10219	40317-40319	,	denotes	,
T10220	40319-40326	JJ	denotes	genomic
T10221	40327-40336	NNS	denotes	sequences
T10222	40338-40342	IN	denotes	from
T10223	40343-40346	DT	denotes	the
T10225	40347-40352	JJ	denotes	fresh
T10226	40353-40358	NN	denotes	water
T10224	40359-40369	NN	denotes	pufferfish
T10227	40369-40371	,	denotes	,
T10228	40371-40380	NNP	denotes	Tetraodon
T10229	40381-40393	NNP	denotes	nigroviridis
T10230	40394-40398	VBD	denotes	were
T10213	40399-40403	VBN	denotes	used
T10231	40404-40406	IN	denotes	as
T10232	40407-40417	JJ	denotes	additional
T10233	40418-40423	NNS	denotes	means
T10234	40424-40426	TO	denotes	to
T10235	40427-40433	VB	denotes	verify
T10236	40434-40437	DT	denotes	the
T10238	40438-40447	VBN	denotes	predicted
T10237	40448-40453	NNS	denotes	exons
T10239	40453-40454	.	denotes	.
T10240	40454-40754	sentence	denotes	Due to the variability of the central region of vertebrate TACC3 cDNAs (see text), to further confirm prediction of the Takifugu rubripes TACC3, full length cDNAs corresponding to the Danio rerio TACC3 (IMAGE clones 2639991, 2640369 and 3724452) were also obtained from A.T.C.C. and fully sequenced.
T10241	40455-40458	IN	denotes	Due
T10243	40459-40461	IN	denotes	to
T10244	40462-40465	DT	denotes	the
T10245	40466-40477	NN	denotes	variability
T10246	40478-40480	IN	denotes	of
T10247	40481-40484	DT	denotes	the
T10249	40485-40492	JJ	denotes	central
T10248	40493-40499	NN	denotes	region
T10250	40500-40502	IN	denotes	of
T10251	40503-40513	NN	denotes	vertebrate
T10253	40514-40519	NN	denotes	TACC3
T10252	40520-40525	NNS	denotes	cDNAs
T10254	40526-40527	-LRB-	denotes	(
T10255	40527-40530	VB	denotes	see
T10256	40531-40535	NN	denotes	text
T10257	40535-40536	-RRB-	denotes	)
T10258	40536-40538	,	denotes	,
T10259	40538-40540	TO	denotes	to
T10261	40541-40548	RB	denotes	further
T10260	40549-40556	VB	denotes	confirm
T10262	40557-40567	NN	denotes	prediction
T10263	40568-40570	IN	denotes	of
T10264	40571-40574	DT	denotes	the
T10266	40575-40583	NNP	denotes	Takifugu
T10265	40584-40592	NNP	denotes	rubripes
T10267	40593-40598	NN	denotes	TACC3
T10268	40598-40600	,	denotes	,
T10269	40600-40604	JJ	denotes	full
T10270	40605-40611	NN	denotes	length
T10271	40612-40617	NNS	denotes	cDNAs
T10272	40618-40631	VBG	denotes	corresponding
T10273	40632-40634	IN	denotes	to
T10274	40635-40638	DT	denotes	the
T10276	40639-40644	NNP	denotes	Danio
T10277	40645-40650	NNP	denotes	rerio
T10275	40651-40656	NN	denotes	TACC3
T10278	40657-40658	-LRB-	denotes	(
T10280	40658-40663	NN	denotes	IMAGE
T10281	40664-40670	NNS	denotes	clones
T10279	40671-40678	CD	denotes	2639991
T10282	40678-40680	,	denotes	,
T10283	40680-40687	CD	denotes	2640369
T10284	40688-40691	CC	denotes	and
T10285	40692-40699	CD	denotes	3724452
T10286	40699-40700	-RRB-	denotes	)
T10287	40701-40705	VBD	denotes	were
T10288	40706-40710	RB	denotes	also
T10242	40711-40719	VBN	denotes	obtained
T10289	40720-40724	IN	denotes	from
T10290	40725-40733	NN	denotes	A.T.C.C.
T10291	40734-40737	CC	denotes	and
T10292	40738-40743	RB	denotes	fully
T10293	40744-40753	VBN	denotes	sequenced
T10294	40753-40754	.	denotes	.
T10295	40754-40932	sentence	denotes	Potential paralogous chromosomal segments and scaffold were identified by searching the public databases deposited at NCBI and at the Human Genome Mapping Project, Cambridge UK.
T10296	40755-40764	JJ	denotes	Potential
T10298	40765-40775	JJ	denotes	paralogous
T10299	40776-40787	JJ	denotes	chromosomal
T10297	40788-40796	NNS	denotes	segments
T10301	40797-40800	CC	denotes	and
T10302	40801-40809	NN	denotes	scaffold
T10303	40810-40814	VBD	denotes	were
T10300	40815-40825	VBN	denotes	identified
T10304	40826-40828	IN	denotes	by
T10305	40829-40838	VBG	denotes	searching
T10306	40839-40842	DT	denotes	the
T10308	40843-40849	JJ	denotes	public
T10307	40850-40859	NNS	denotes	databases
T10309	40860-40869	VBN	denotes	deposited
T10310	40870-40872	IN	denotes	at
T10311	40873-40877	NNP	denotes	NCBI
T10312	40878-40881	CC	denotes	and
T10313	40882-40884	IN	denotes	at
T10314	40885-40888	DT	denotes	the
T10316	40889-40894	NNP	denotes	Human
T10317	40895-40901	NNP	denotes	Genome
T10318	40902-40909	NNP	denotes	Mapping
T10315	40910-40917	NNP	denotes	Project
T10319	40917-40919	,	denotes	,
T10320	40919-40928	NNP	denotes	Cambridge
T10321	40929-40931	NNP	denotes	UK
T10322	40931-40932	.	denotes	.
T10439	40934-40941	NN	denotes	Cloning
T10440	40942-40944	IN	denotes	of
T10441	40945-40955	NN	denotes	vertebrate
T10442	40956-40960	NN	denotes	TACC
T10443	40961-40966	NNS	denotes	cDNAs
T10444	40966-41231	sentence	denotes	The rabbit TACC3 was cloned by rt-PCR using the "TACC4" specific primer T4RACE2 [9] (5'-cccgaactgctccaggtaatcgatctc-3') and a consensus primer, T3con2, designed to the region encompassing the vertebrate TACC3 initiator methionine (5'-tatgagtctgcaggtcttaaacgac-3').
T10445	40967-40970	DT	denotes	The
T10447	40971-40977	NN	denotes	rabbit
T10446	40978-40983	NN	denotes	TACC3
T10449	40984-40987	VBD	denotes	was
T10448	40988-40994	VBN	denotes	cloned
T10450	40995-40997	IN	denotes	by
T10451	40998-41000	NN	denotes	rt
T10453	41000-41001	HYPH	denotes	-
T10452	41001-41004	NN	denotes	PCR
T10454	41005-41010	VBG	denotes	using
T10455	41011-41014	DT	denotes	the
T10457	41015-41016	``	denotes	"
T10459	41016-41021	NN	denotes	TACC4
T10460	41021-41022	''	denotes	"
T10458	41023-41031	JJ	denotes	specific
T10456	41032-41038	NN	denotes	primer
T10461	41039-41046	NN	denotes	T4RACE2
T10462	41047-41048	-LRB-	denotes	[
T10463	41048-41049	CD	denotes	9
T10464	41049-41050	-RRB-	denotes	]
T10465	41051-41052	-LRB-	denotes	(
T10467	41052-41053	CD	denotes	5
T10468	41053-41054	SYM	denotes	'
T10469	41054-41055	HYPH	denotes	-
T10466	41055-41082	NN	denotes	cccgaactgctccaggtaatcgatctc
T10470	41082-41083	HYPH	denotes	-
T10471	41083-41084	CD	denotes	3
T10472	41084-41085	SYM	denotes	'
T10473	41085-41086	-RRB-	denotes	)
T10474	41087-41090	CC	denotes	and
T10475	41091-41092	DT	denotes	a
T10477	41093-41102	NN	denotes	consensus
T10476	41103-41109	NN	denotes	primer
T10478	41109-41111	,	denotes	,
T10479	41111-41117	NN	denotes	T3con2
T10480	41117-41119	,	denotes	,
T10481	41119-41127	VBN	denotes	designed
T10482	41128-41130	IN	denotes	to
T10483	41131-41134	DT	denotes	the
T10484	41135-41141	NN	denotes	region
T10485	41142-41154	VBG	denotes	encompassing
T10486	41155-41158	DT	denotes	the
T10488	41159-41169	NN	denotes	vertebrate
T10489	41170-41175	NN	denotes	TACC3
T10487	41176-41185	NN	denotes	initiator
T10490	41186-41196	NN	denotes	methionine
T10491	41197-41198	-LRB-	denotes	(
T10493	41198-41199	CD	denotes	5
T10494	41199-41200	SYM	denotes	'
T10495	41200-41201	HYPH	denotes	-
T10492	41201-41226	NN	denotes	tatgagtctgcaggtcttaaacgac
T10496	41226-41227	HYPH	denotes	-
T10497	41227-41228	CD	denotes	3
T10498	41228-41229	SYM	denotes	'
T10499	41229-41230	-RRB-	denotes	)
T10500	41230-41231	.	denotes	.
T10501	41231-41617	sentence	denotes	For cloning the mouse Tacc1X cDNA, the primers used were based upon the genomic sequence reported, and the sequence of the IMAGE cDNA clone 4933429K08: T1XF (5'-ccatgttcagtcattggcaggtc-3'), T1XF2 (5'-ctgcagaaccaacagttcaag-3'), T1XR1 (5'-agatctgtgacatcacagctc-3'), T1XR2 (5'-ctcgagtcagttagtcttatccagctt-3'), BB617F (5'-accaccaacttgagtacctg-3') and BB617R (5'-gtatcttgaactgttggttctg-3').
T10502	41232-41235	IN	denotes	For
T10504	41236-41243	VBG	denotes	cloning
T10505	41244-41247	DT	denotes	the
T10507	41248-41253	NN	denotes	mouse
T10508	41254-41260	NN	denotes	Tacc1X
T10506	41261-41265	NN	denotes	cDNA
T10509	41265-41267	,	denotes	,
T10510	41267-41270	DT	denotes	the
T10511	41271-41278	NNS	denotes	primers
T10512	41279-41283	VBN	denotes	used
T10513	41284-41288	VBD	denotes	were
T10503	41289-41294	VBN	denotes	based
T10514	41295-41299	IN	denotes	upon
T10515	41300-41303	DT	denotes	the
T10517	41304-41311	JJ	denotes	genomic
T10516	41312-41320	NN	denotes	sequence
T10518	41321-41329	VBN	denotes	reported
T10519	41329-41331	,	denotes	,
T10520	41331-41334	CC	denotes	and
T10521	41335-41338	DT	denotes	the
T10522	41339-41347	NN	denotes	sequence
T10523	41348-41350	IN	denotes	of
T10524	41351-41354	DT	denotes	the
T10526	41355-41360	NN	denotes	IMAGE
T10527	41361-41365	NN	denotes	cDNA
T10525	41366-41371	NN	denotes	clone
T10528	41372-41382	NN	denotes	4933429K08
T10529	41382-41384	:	denotes	:
T10530	41384-41388	NN	denotes	T1XF
T10531	41389-41390	-LRB-	denotes	(
T10533	41390-41391	CD	denotes	5
T10534	41391-41392	SYM	denotes	'
T10535	41392-41393	HYPH	denotes	-
T10532	41393-41416	NN	denotes	ccatgttcagtcattggcaggtc
T10536	41416-41417	HYPH	denotes	-
T10537	41417-41418	CD	denotes	3
T10538	41418-41419	SYM	denotes	'
T10539	41419-41420	-RRB-	denotes	)
T10540	41420-41422	,	denotes	,
T10541	41422-41427	NN	denotes	T1XF2
T10542	41428-41429	-LRB-	denotes	(
T10544	41429-41430	CD	denotes	5
T10545	41430-41431	SYM	denotes	'
T10546	41431-41432	HYPH	denotes	-
T10543	41432-41453	NN	denotes	ctgcagaaccaacagttcaag
T10547	41453-41454	HYPH	denotes	-
T10548	41454-41455	CD	denotes	3
T10549	41455-41456	SYM	denotes	'
T10550	41456-41457	-RRB-	denotes	)
T10551	41457-41459	,	denotes	,
T10552	41459-41464	NN	denotes	T1XR1
T10553	41465-41466	-LRB-	denotes	(
T10555	41466-41467	CD	denotes	5
T10556	41467-41468	SYM	denotes	'
T10557	41468-41469	HYPH	denotes	-
T10554	41469-41490	NN	denotes	agatctgtgacatcacagctc
T10558	41490-41491	HYPH	denotes	-
T10559	41491-41492	CD	denotes	3
T10560	41492-41493	SYM	denotes	'
T10561	41493-41494	-RRB-	denotes	)
T10562	41494-41496	,	denotes	,
T10563	41496-41501	NN	denotes	T1XR2
T10564	41502-41503	-LRB-	denotes	(
T10566	41503-41504	CD	denotes	5
T10567	41504-41505	SYM	denotes	'
T10568	41505-41506	HYPH	denotes	-
T10565	41506-41533	NN	denotes	ctcgagtcagttagtcttatccagctt
T10569	41533-41534	HYPH	denotes	-
T10570	41534-41535	CD	denotes	3
T10571	41535-41536	SYM	denotes	'
T10572	41536-41537	-RRB-	denotes	)
T10573	41537-41539	,	denotes	,
T10574	41539-41545	NN	denotes	BB617F
T10575	41546-41547	-LRB-	denotes	(
T10577	41547-41548	CD	denotes	5
T10578	41548-41549	SYM	denotes	'
T10579	41549-41550	HYPH	denotes	-
T10576	41550-41570	NN	denotes	accaccaacttgagtacctg
T10580	41570-41571	HYPH	denotes	-
T10581	41571-41572	CD	denotes	3
T10582	41572-41573	SYM	denotes	'
T10583	41573-41574	-RRB-	denotes	)
T10584	41575-41578	CC	denotes	and
T10585	41579-41585	NN	denotes	BB617R
T10586	41586-41587	-LRB-	denotes	(
T10588	41587-41588	CD	denotes	5
T10589	41588-41589	SYM	denotes	'
T10590	41589-41590	HYPH	denotes	-
T10587	41590-41612	NN	denotes	gtatcttgaactgttggttctg
T10591	41612-41613	HYPH	denotes	-
T10592	41613-41614	CD	denotes	3
T10593	41614-41615	SYM	denotes	'
T10594	41615-41616	-RRB-	denotes	)
T10595	41616-41617	.	denotes	.
T10596	41617-41824	sentence	denotes	For analysis of TACC1 splice variants, the forward primers used were located in exon 1b: EF (5'-gagagatgcgaaatcagcg-3'), Exon 1d: X3F (5'-agtcaaagaaggcatctgcag-3'), Exon 1a: 1DF (5'-ccaagttctgcgccatggg-3').
T10597	41618-41621	IN	denotes	For
T10599	41622-41630	NN	denotes	analysis
T10600	41631-41633	IN	denotes	of
T10601	41634-41639	NN	denotes	TACC1
T10603	41640-41646	NN	denotes	splice
T10602	41647-41655	NNS	denotes	variants
T10604	41655-41657	,	denotes	,
T10605	41657-41660	DT	denotes	the
T10607	41661-41668	JJ	denotes	forward
T10606	41669-41676	NNS	denotes	primers
T10608	41677-41681	VBN	denotes	used
T10609	41682-41686	VBD	denotes	were
T10598	41687-41694	VBN	denotes	located
T10610	41695-41697	IN	denotes	in
T10611	41698-41702	NN	denotes	exon
T10612	41703-41705	CD	denotes	1b
T10613	41705-41707	:	denotes	:
T10614	41707-41709	NN	denotes	EF
T10616	41710-41711	-LRB-	denotes	(
T10617	41711-41712	CD	denotes	5
T10618	41712-41713	SYM	denotes	'
T10619	41713-41714	HYPH	denotes	-
T10615	41714-41733	NN	denotes	gagagatgcgaaatcagcg
T10620	41733-41734	HYPH	denotes	-
T10621	41734-41735	CD	denotes	3
T10622	41735-41736	SYM	denotes	'
T10623	41736-41737	-RRB-	denotes	)
T10624	41737-41739	,	denotes	,
T10625	41739-41743	NN	denotes	Exon
T10626	41744-41746	CD	denotes	1d
T10627	41746-41748	:	denotes	:
T10628	41748-41751	NN	denotes	X3F
T10630	41752-41753	-LRB-	denotes	(
T10631	41753-41754	CD	denotes	5
T10632	41754-41755	SYM	denotes	'
T10633	41755-41756	HYPH	denotes	-
T10629	41756-41777	NN	denotes	agtcaaagaaggcatctgcag
T10634	41777-41778	HYPH	denotes	-
T10635	41778-41779	CD	denotes	3
T10636	41779-41780	SYM	denotes	'
T10637	41780-41781	-RRB-	denotes	)
T10638	41781-41783	,	denotes	,
T10639	41783-41787	NN	denotes	Exon
T10640	41788-41790	CD	denotes	1a
T10641	41790-41792	:	denotes	:
T10642	41792-41795	NN	denotes	1DF
T10644	41796-41797	-LRB-	denotes	(
T10645	41797-41798	CD	denotes	5
T10646	41798-41799	SYM	denotes	'
T10647	41799-41800	HYPH	denotes	-
T10643	41800-41819	NN	denotes	ccaagttctgcgccatggg
T10648	41819-41820	HYPH	denotes	-
T10649	41820-41821	CD	denotes	3
T10650	41821-41822	SYM	denotes	'
T10651	41822-41823	-RRB-	denotes	)
T10652	41823-41824	.	denotes	.
T10653	41824-42083	sentence	denotes	The reverse primers used were: Exon 1: X1R (5'-ggatttggtctcggcttgcgaatc-3'), Exon 2: BX647R (5'-cttgtgattcttggcttttgg-3'), Exon 3: 6SPR (5'-gtcatcgcctcgtcctggagggc-3'), Exon 4a: 1DR (5'-aatttcacttgttcagtagtc-3'), Exon 5: 128R (5'-cctgcttctgaggatgaaaacgc-3').
T10654	41825-41828	DT	denotes	The
T10656	41829-41836	JJ	denotes	reverse
T10655	41837-41844	NNS	denotes	primers
T10658	41845-41849	VBN	denotes	used
T10657	41850-41854	VBD	denotes	were
T10659	41854-41856	:	denotes	:
T10660	41856-41860	NN	denotes	Exon
T10661	41861-41862	CD	denotes	1
T10662	41862-41864	:	denotes	:
T10663	41864-41867	NN	denotes	X1R
T10665	41868-41869	-LRB-	denotes	(
T10666	41869-41870	CD	denotes	5
T10667	41870-41871	SYM	denotes	'
T10668	41871-41872	HYPH	denotes	-
T10664	41872-41896	NN	denotes	ggatttggtctcggcttgcgaatc
T10669	41896-41897	HYPH	denotes	-
T10670	41897-41898	CD	denotes	3
T10671	41898-41899	SYM	denotes	'
T10672	41899-41900	-RRB-	denotes	)
T10673	41900-41902	,	denotes	,
T10674	41902-41906	NN	denotes	Exon
T10675	41907-41908	CD	denotes	2
T10676	41908-41910	:	denotes	:
T10677	41910-41916	NN	denotes	BX647R
T10679	41917-41918	-LRB-	denotes	(
T10680	41918-41919	CD	denotes	5
T10681	41919-41920	SYM	denotes	'
T10682	41920-41921	HYPH	denotes	-
T10678	41921-41942	NN	denotes	cttgtgattcttggcttttgg
T10683	41942-41943	HYPH	denotes	-
T10684	41943-41944	CD	denotes	3
T10685	41944-41945	SYM	denotes	'
T10686	41945-41946	-RRB-	denotes	)
T10687	41946-41948	,	denotes	,
T10688	41948-41952	NN	denotes	Exon
T10689	41953-41954	CD	denotes	3
T10690	41954-41956	:	denotes	:
T10691	41956-41960	NN	denotes	6SPR
T10693	41961-41962	-LRB-	denotes	(
T10694	41962-41963	CD	denotes	5
T10695	41963-41964	SYM	denotes	'
T10696	41964-41965	HYPH	denotes	-
T10692	41965-41988	NN	denotes	gtcatcgcctcgtcctggagggc
T10697	41988-41989	HYPH	denotes	-
T10698	41989-41990	CD	denotes	3
T10699	41990-41991	SYM	denotes	'
T10700	41991-41992	-RRB-	denotes	)
T10701	41992-41994	,	denotes	,
T10702	41994-41998	NN	denotes	Exon
T10703	41999-42001	NN	denotes	4a
T10704	42001-42003	:	denotes	:
T10705	42003-42006	NN	denotes	1DR
T10707	42007-42008	-LRB-	denotes	(
T10708	42008-42009	CD	denotes	5
T10709	42009-42010	SYM	denotes	'
T10710	42010-42011	HYPH	denotes	-
T10706	42011-42032	NN	denotes	aatttcacttgttcagtagtc
T10711	42032-42033	HYPH	denotes	-
T10712	42033-42034	CD	denotes	3
T10713	42034-42035	SYM	denotes	'
T10714	42035-42036	-RRB-	denotes	)
T10715	42036-42038	,	denotes	,
T10716	42038-42042	NN	denotes	Exon
T10717	42043-42044	CD	denotes	5
T10718	42044-42046	:	denotes	:
T10719	42046-42050	NN	denotes	128R
T10721	42051-42052	-LRB-	denotes	(
T10722	42052-42053	CD	denotes	5
T10723	42053-42054	SYM	denotes	'
T10724	42054-42055	HYPH	denotes	-
T10720	42055-42078	NN	denotes	cctgcttctgaggatgaaaacgc
T10725	42078-42079	HYPH	denotes	-
T10726	42079-42080	CD	denotes	3
T10727	42080-42081	SYM	denotes	'
T10728	42081-42082	-RRB-	denotes	)
T10729	42082-42083	.	denotes	.
T10730	42083-42216	sentence	denotes	Rabbit brain poly A+ mRNA, mouse testis and human brain total RNA were obtained from BD Bioscience Clontech (Palo Alto, CA, U.S.A.).
T10731	42084-42090	NN	denotes	Rabbit
T10732	42091-42096	NN	denotes	brain
T10734	42097-42101	NN	denotes	poly
T10735	42102-42104	NN	denotes	A+
T10733	42105-42109	NN	denotes	mRNA
T10737	42109-42111	,	denotes	,
T10738	42111-42116	NN	denotes	mouse
T10739	42117-42123	NN	denotes	testis
T10740	42124-42127	CC	denotes	and
T10741	42128-42133	JJ	denotes	human
T10742	42134-42139	NN	denotes	brain
T10744	42140-42145	JJ	denotes	total
T10743	42146-42149	NN	denotes	RNA
T10745	42150-42154	VBD	denotes	were
T10736	42155-42163	VBN	denotes	obtained
T10746	42164-42168	IN	denotes	from
T10747	42169-42171	NNP	denotes	BD
T10749	42172-42182	NNP	denotes	Bioscience
T10748	42183-42191	NNP	denotes	Clontech
T10750	42192-42193	-LRB-	denotes	(
T10751	42193-42197	NNP	denotes	Palo
T10752	42198-42202	NNP	denotes	Alto
T10753	42202-42204	,	denotes	,
T10754	42204-42206	NNP	denotes	CA
T10755	42206-42208	,	denotes	,
T10756	42208-42214	NNP	denotes	U.S.A.
T10757	42214-42215	-RRB-	denotes	)
T10758	42215-42216	.	denotes	.
T10759	42216-42386	sentence	denotes	Reverse transcription and PCR was performed as previously described, using either 1 μg of total RNA or 50 ng of poly A+ mRNA as template for first strand cDNA synthesis.
T10760	42217-42224	JJ	denotes	Reverse
T10761	42225-42238	NN	denotes	transcription
T10763	42239-42242	CC	denotes	and
T10764	42243-42246	NN	denotes	PCR
T10765	42247-42250	VBD	denotes	was
T10762	42251-42260	VBN	denotes	performed
T10766	42261-42263	IN	denotes	as
T10768	42264-42274	RB	denotes	previously
T10767	42275-42284	VBN	denotes	described
T10769	42284-42286	,	denotes	,
T10770	42286-42291	VBG	denotes	using
T10771	42292-42298	CC	denotes	either
T10773	42299-42300	CD	denotes	1
T10772	42301-42303	NN	denotes	μg
T10774	42304-42306	IN	denotes	of
T10775	42307-42312	JJ	denotes	total
T10776	42313-42316	NN	denotes	RNA
T10777	42317-42319	CC	denotes	or
T10778	42320-42322	CD	denotes	50
T10779	42323-42325	NNS	denotes	ng
T10780	42326-42328	IN	denotes	of
T10781	42329-42333	NN	denotes	poly
T10782	42334-42336	NN	denotes	A+
T10783	42337-42341	NN	denotes	mRNA
T10784	42342-42344	IN	denotes	as
T10785	42345-42353	NN	denotes	template
T10786	42354-42357	IN	denotes	for
T10787	42358-42363	JJ	denotes	first
T10788	42364-42370	NN	denotes	strand
T10789	42371-42375	NN	denotes	cDNA
T10790	42376-42385	NN	denotes	synthesis
T10791	42385-42386	.	denotes	.
T10792	42386-42502	sentence	denotes	PCR products were cloned into pCR2.1 (Invitrogen, Carlsbad CA, U.S.A.) and transformed into InvαF' competent cells.
T10793	42387-42390	NN	denotes	PCR
T10794	42391-42399	NNS	denotes	products
T10796	42400-42404	VBD	denotes	were
T10795	42405-42411	VBN	denotes	cloned
T10797	42412-42416	IN	denotes	into
T10798	42417-42423	NN	denotes	pCR2.1
T10799	42424-42425	-LRB-	denotes	(
T10800	42425-42435	NNP	denotes	Invitrogen
T10801	42435-42437	,	denotes	,
T10802	42437-42445	NNP	denotes	Carlsbad
T10803	42446-42448	NNP	denotes	CA
T10804	42448-42450	,	denotes	,
T10805	42450-42456	NNP	denotes	U.S.A.
T10806	42456-42457	-RRB-	denotes	)
T10807	42458-42461	CC	denotes	and
T10808	42462-42473	VBN	denotes	transformed
T10809	42474-42478	IN	denotes	into
T10810	42479-42484	NN	denotes	InvαF
T10812	42484-42485	POS	denotes	'
T10811	42486-42495	JJ	denotes	competent
T10813	42496-42501	NNS	denotes	cells
T10814	42501-42502	.	denotes	.
T10815	42502-42596	sentence	denotes	Plasmid inserts were sequenced by the Roswell Park Cancer Institute Biopolymer Core Facility.
T10816	42503-42510	NN	denotes	Plasmid
T10817	42511-42518	NNS	denotes	inserts
T10819	42519-42523	VBD	denotes	were
T10818	42524-42533	VBN	denotes	sequenced
T10820	42534-42536	IN	denotes	by
T10821	42537-42540	DT	denotes	the
T10823	42541-42548	NNP	denotes	Roswell
T10824	42549-42553	NNP	denotes	Park
T10826	42554-42560	NNP	denotes	Cancer
T10825	42561-42570	NNP	denotes	Institute
T10827	42571-42581	NNP	denotes	Biopolymer
T10828	42582-42586	NNP	denotes	Core
T10822	42587-42595	NNP	denotes	Facility
T10829	42595-42596	.	denotes	.
T10982	42598-42608	NN	denotes	Deposition
T10983	42609-42611	IN	denotes	of
T10984	42612-42622	NN	denotes	nucleotide
T10985	42623-42632	NNS	denotes	sequences
T10986	42632-42984	sentence	denotes	Sequences from this article have been deposited in the GenBank database with the following accession numbers: Homo sapiens TACC1 short isoform S (AY177411), Mus musculus TACC1 short isoform S (AY177412), Mus musculus TACC1 long isoform A (AY177413), Mus musculus TACC2s (AY177410), Oryctolagus cuniculus TACC3 (AY161270), Danio rerio TACC3 (AY170618).
T10987	42633-42642	NNS	denotes	Sequences
T10989	42643-42647	IN	denotes	from
T10990	42648-42652	DT	denotes	this
T10991	42653-42660	NN	denotes	article
T10992	42661-42665	VBP	denotes	have
T10993	42666-42670	VBN	denotes	been
T10988	42671-42680	VBN	denotes	deposited
T10994	42681-42683	IN	denotes	in
T10995	42684-42687	DT	denotes	the
T10997	42688-42695	NNP	denotes	GenBank
T10996	42696-42704	NN	denotes	database
T10998	42705-42709	IN	denotes	with
T10999	42710-42713	DT	denotes	the
T11001	42714-42723	VBG	denotes	following
T11002	42724-42733	NN	denotes	accession
T11000	42734-42741	NNS	denotes	numbers
T11003	42741-42743	:	denotes	:
T11004	42743-42747	NNP	denotes	Homo
T11005	42748-42755	NNP	denotes	sapiens
T11007	42756-42761	NN	denotes	TACC1
T11008	42762-42767	JJ	denotes	short
T11009	42768-42775	NN	denotes	isoform
T11006	42776-42777	NN	denotes	S
T11010	42778-42779	-LRB-	denotes	(
T11011	42779-42787	NN	denotes	AY177411
T11012	42787-42788	-RRB-	denotes	)
T11013	42788-42790	,	denotes	,
T11014	42790-42793	NNP	denotes	Mus
T11015	42794-42802	NNP	denotes	musculus
T11017	42803-42808	NN	denotes	TACC1
T11018	42809-42814	JJ	denotes	short
T11019	42815-42822	NN	denotes	isoform
T11016	42823-42824	NN	denotes	S
T11020	42825-42826	-LRB-	denotes	(
T11021	42826-42834	NN	denotes	AY177412
T11022	42834-42835	-RRB-	denotes	)
T11023	42835-42837	,	denotes	,
T11024	42837-42840	NNP	denotes	Mus
T11025	42841-42849	NNP	denotes	musculus
T11027	42850-42855	NN	denotes	TACC1
T11028	42856-42860	JJ	denotes	long
T11029	42861-42868	NN	denotes	isoform
T11026	42869-42870	NN	denotes	A
T11030	42871-42872	-LRB-	denotes	(
T11031	42872-42880	NN	denotes	AY177413
T11032	42880-42881	-RRB-	denotes	)
T11033	42881-42883	,	denotes	,
T11034	42883-42886	NNP	denotes	Mus
T11035	42887-42895	NNP	denotes	musculus
T11036	42896-42902	NNS	denotes	TACC2s
T11037	42903-42904	-LRB-	denotes	(
T11038	42904-42912	NN	denotes	AY177410
T11039	42912-42913	-RRB-	denotes	)
T11040	42913-42915	,	denotes	,
T11041	42915-42926	NNP	denotes	Oryctolagus
T11042	42927-42936	NNP	denotes	cuniculus
T11043	42937-42942	NN	denotes	TACC3
T11044	42943-42944	-LRB-	denotes	(
T11045	42944-42952	NN	denotes	AY161270
T11046	42952-42953	-RRB-	denotes	)
T11047	42953-42955	,	denotes	,
T11048	42955-42960	NNP	denotes	Danio
T11049	42961-42966	NNP	denotes	rerio
T11050	42967-42972	NN	denotes	TACC3
T11051	42973-42974	-LRB-	denotes	(
T11052	42974-42982	NN	denotes	AY170618
T11053	42982-42983	-RRB-	denotes	)
T11054	42983-42984	.	denotes	.
T11055	42984-43698	sentence	denotes	Annotations submitted to the Third party annotation database at NCBI are as follows: Rattus norvegus TACC1 long isoform A (BK001653), Takifugu rubripes TACC1A (BK000666/BK000667), Takifugu rubripes TACC1B (BK000664), Mus musculus TACC2l (BK001495), Rattus norvegus TACC2l (BK001658), Rattus norvegus TACC2s (BK001657), Takifugu rubripes TACC2l (BK000690), Rattus norvegus TACC3 (BK001491), Gallus gallus TACC3 (BK001482), Silurana tropicalis TACC3 (BK001481),Takifugu rubripes TACC3 (BK000649), Takifugu rubripes RHAMM (BK000676), Ciona intestinalis RHAMM (BK001479), Takifugu rubripes Keratin (BK000677), Takifugu rubripes TPM1 (BAC10576), Ciona intestinalis Kif3b (BK001492), Ciona intestinalis klp2 (BK001493).
T11056	42985-42996	NNS	denotes	Annotations
T11058	42997-43006	VBN	denotes	submitted
T11059	43007-43009	IN	denotes	to
T11060	43010-43013	DT	denotes	the
T11062	43014-43019	JJ	denotes	Third
T11063	43020-43025	NN	denotes	party
T11064	43026-43036	NN	denotes	annotation
T11061	43037-43045	NN	denotes	database
T11065	43046-43048	IN	denotes	at
T11066	43049-43053	NNP	denotes	NCBI
T11057	43054-43057	VBP	denotes	are
T11067	43058-43060	IN	denotes	as
T11068	43061-43068	VBZ	denotes	follows
T11069	43068-43070	:	denotes	:
T11070	43070-43076	NNP	denotes	Rattus
T11071	43077-43085	NNP	denotes	norvegus
T11073	43086-43091	NN	denotes	TACC1
T11074	43092-43096	JJ	denotes	long
T11075	43097-43104	NN	denotes	isoform
T11072	43105-43106	NN	denotes	A
T11076	43107-43108	-LRB-	denotes	(
T11077	43108-43116	NN	denotes	BK001653
T11078	43116-43117	-RRB-	denotes	)
T11079	43117-43119	,	denotes	,
T11080	43119-43127	NNP	denotes	Takifugu
T11081	43128-43136	NNP	denotes	rubripes
T11082	43137-43143	NN	denotes	TACC1A
T11083	43144-43145	-LRB-	denotes	(
T11085	43145-43153	NN	denotes	BK000666
T11086	43153-43154	HYPH	denotes	/
T11084	43154-43162	NN	denotes	BK000667
T11087	43162-43163	-RRB-	denotes	)
T11088	43163-43165	,	denotes	,
T11089	43165-43173	NNP	denotes	Takifugu
T11090	43174-43182	NNP	denotes	rubripes
T11091	43183-43189	NN	denotes	TACC1B
T11092	43190-43191	-LRB-	denotes	(
T11093	43191-43199	NN	denotes	BK000664
T11094	43199-43200	-RRB-	denotes	)
T11095	43200-43202	,	denotes	,
T11096	43202-43205	NNP	denotes	Mus
T11097	43206-43214	NNP	denotes	musculus
T11098	43215-43221	NN	denotes	TACC2l
T11099	43222-43223	-LRB-	denotes	(
T11100	43223-43231	NN	denotes	BK001495
T11101	43231-43232	-RRB-	denotes	)
T11102	43232-43234	,	denotes	,
T11103	43234-43240	NNP	denotes	Rattus
T11104	43241-43249	NNP	denotes	norvegus
T11105	43250-43256	NN	denotes	TACC2l
T11106	43257-43258	-LRB-	denotes	(
T11107	43258-43266	NN	denotes	BK001658
T11108	43266-43267	-RRB-	denotes	)
T11109	43267-43269	,	denotes	,
T11110	43269-43275	NNP	denotes	Rattus
T11111	43276-43284	NNP	denotes	norvegus
T11112	43285-43291	NNS	denotes	TACC2s
T11113	43292-43293	-LRB-	denotes	(
T11114	43293-43301	NN	denotes	BK001657
T11115	43301-43302	-RRB-	denotes	)
T11116	43302-43304	,	denotes	,
T11117	43304-43312	NNP	denotes	Takifugu
T11118	43313-43321	NNP	denotes	rubripes
T11119	43322-43328	NN	denotes	TACC2l
T11120	43329-43330	-LRB-	denotes	(
T11121	43330-43338	NN	denotes	BK000690
T11122	43338-43339	-RRB-	denotes	)
T11123	43339-43341	,	denotes	,
T11124	43341-43347	NNP	denotes	Rattus
T11125	43348-43356	NNP	denotes	norvegus
T11126	43357-43362	NN	denotes	TACC3
T11127	43363-43364	-LRB-	denotes	(
T11128	43364-43372	NN	denotes	BK001491
T11129	43372-43373	-RRB-	denotes	)
T11130	43373-43375	,	denotes	,
T11131	43375-43381	NNP	denotes	Gallus
T11132	43382-43388	NNP	denotes	gallus
T11133	43389-43394	NN	denotes	TACC3
T11134	43395-43396	-LRB-	denotes	(
T11135	43396-43404	NN	denotes	BK001482
T11136	43404-43405	-RRB-	denotes	)
T11137	43405-43407	,	denotes	,
T11138	43407-43415	NNP	denotes	Silurana
T11139	43416-43426	NNP	denotes	tropicalis
T11140	43427-43432	NN	denotes	TACC3
T11141	43433-43434	-LRB-	denotes	(
T11142	43434-43442	NN	denotes	BK001481
T11143	43442-43443	-RRB-	denotes	)
T11144	43443-43444	,	denotes	,
T11145	43444-43452	NNP	denotes	Takifugu
T11146	43453-43461	NNP	denotes	rubripes
T11147	43462-43467	NN	denotes	TACC3
T11148	43468-43469	-LRB-	denotes	(
T11149	43469-43477	NN	denotes	BK000649
T11150	43477-43478	-RRB-	denotes	)
T11151	43478-43480	,	denotes	,
T11152	43480-43488	NNP	denotes	Takifugu
T11153	43489-43497	NNP	denotes	rubripes
T11154	43498-43503	NN	denotes	RHAMM
T11155	43504-43505	-LRB-	denotes	(
T11156	43505-43513	NN	denotes	BK000676
T11157	43513-43514	-RRB-	denotes	)
T11158	43514-43516	,	denotes	,
T11159	43516-43521	NNP	denotes	Ciona
T11160	43522-43534	NNP	denotes	intestinalis
T11161	43535-43540	NN	denotes	RHAMM
T11162	43541-43542	-LRB-	denotes	(
T11163	43542-43550	NN	denotes	BK001479
T11164	43550-43551	-RRB-	denotes	)
T11165	43551-43553	,	denotes	,
T11166	43553-43561	NNP	denotes	Takifugu
T11167	43562-43570	NNP	denotes	rubripes
T11168	43571-43578	NN	denotes	Keratin
T11169	43579-43580	-LRB-	denotes	(
T11170	43580-43588	NN	denotes	BK000677
T11171	43588-43589	-RRB-	denotes	)
T11172	43589-43591	,	denotes	,
T11173	43591-43599	NNP	denotes	Takifugu
T11174	43600-43608	NNP	denotes	rubripes
T11175	43609-43613	NN	denotes	TPM1
T11176	43614-43615	-LRB-	denotes	(
T11177	43615-43623	NN	denotes	BAC10576
T11178	43623-43624	-RRB-	denotes	)
T11179	43624-43626	,	denotes	,
T11180	43626-43631	NNP	denotes	Ciona
T11181	43632-43644	NNP	denotes	intestinalis
T11182	43645-43650	NN	denotes	Kif3b
T11183	43651-43652	-LRB-	denotes	(
T11184	43652-43660	NN	denotes	BK001492
T11185	43660-43661	-RRB-	denotes	)
T11186	43661-43663	,	denotes	,
T11187	43663-43668	NNP	denotes	Ciona
T11188	43669-43681	NNP	denotes	intestinalis
T11189	43682-43686	NN	denotes	klp2
T11190	43687-43688	-LRB-	denotes	(
T11191	43688-43696	NN	denotes	BK001493
T11192	43696-43697	-RRB-	denotes	)
T11193	43697-43698	.	denotes	.
T11434	43700-43712	JJ	denotes	Phylogenetic
T11435	43713-43721	NN	denotes	analysis
T11436	43721-44205	sentence	denotes	In order to examine evolutionary relationships of proteins containing coiled coil domains, protein sequences representing the major members of this super family, including TACC, RHAMM, KLP, keratin and tropomyosin from available vertebrates and their recognizable orthologues from the urochordate Ciona intestinalis, Drosophila melanogaster, C. elegans and Saccharomyces cerevisiae were either directly retrieved from NCBI sequence databases, newly predicted or isolated (see above).
T11437	43722-43724	IN	denotes	In
T11439	43725-43730	NN	denotes	order
T11440	43731-43733	TO	denotes	to
T11441	43734-43741	VB	denotes	examine
T11442	43742-43754	JJ	denotes	evolutionary
T11443	43755-43768	NNS	denotes	relationships
T11444	43769-43771	IN	denotes	of
T11445	43772-43780	NN	denotes	proteins
T11446	43781-43791	VBG	denotes	containing
T11447	43792-43798	VBN	denotes	coiled
T11448	43799-43803	NN	denotes	coil
T11449	43804-43811	NNS	denotes	domains
T11450	43811-43813	,	denotes	,
T11451	43813-43820	NN	denotes	protein
T11452	43821-43830	NNS	denotes	sequences
T11453	43831-43843	VBG	denotes	representing
T11454	43844-43847	DT	denotes	the
T11456	43848-43853	JJ	denotes	major
T11455	43854-43861	NNS	denotes	members
T11457	43862-43864	IN	denotes	of
T11458	43865-43869	DT	denotes	this
T11460	43870-43875	JJ	denotes	super
T11459	43876-43882	NN	denotes	family
T11461	43882-43884	,	denotes	,
T11462	43884-43893	VBG	denotes	including
T11463	43894-43898	NN	denotes	TACC
T11464	43898-43900	,	denotes	,
T11465	43900-43905	NN	denotes	RHAMM
T11466	43905-43907	,	denotes	,
T11467	43907-43910	NN	denotes	KLP
T11468	43910-43912	,	denotes	,
T11469	43912-43919	NN	denotes	keratin
T11470	43920-43923	CC	denotes	and
T11471	43924-43935	NN	denotes	tropomyosin
T11472	43936-43940	IN	denotes	from
T11473	43941-43950	JJ	denotes	available
T11474	43951-43962	NNS	denotes	vertebrates
T11475	43963-43966	CC	denotes	and
T11476	43967-43972	PRP$	denotes	their
T11478	43973-43985	JJ	denotes	recognizable
T11477	43986-43997	NNS	denotes	orthologues
T11479	43998-44002	IN	denotes	from
T11480	44003-44006	DT	denotes	the
T11481	44007-44018	NN	denotes	urochordate
T11482	44019-44024	NNP	denotes	Ciona
T11483	44025-44037	NNP	denotes	intestinalis
T11484	44037-44039	,	denotes	,
T11485	44039-44049	NNP	denotes	Drosophila
T11486	44050-44062	NNP	denotes	melanogaster
T11487	44062-44064	,	denotes	,
T11488	44064-44066	NNP	denotes	C.
T11489	44067-44074	NNP	denotes	elegans
T11490	44075-44078	CC	denotes	and
T11491	44079-44092	NNP	denotes	Saccharomyces
T11492	44093-44103	NNP	denotes	cerevisiae
T11493	44104-44108	VBD	denotes	were
T11494	44109-44115	CC	denotes	either
T11495	44116-44124	RB	denotes	directly
T11438	44125-44134	VBN	denotes	retrieved
T11496	44135-44139	IN	denotes	from
T11497	44140-44144	NN	denotes	NCBI
T11499	44145-44153	NN	denotes	sequence
T11498	44154-44163	NNS	denotes	databases
T11500	44163-44165	,	denotes	,
T11501	44165-44170	RB	denotes	newly
T11502	44171-44180	VBN	denotes	predicted
T11503	44181-44183	CC	denotes	or
T11504	44184-44192	VBN	denotes	isolated
T11505	44193-44194	-LRB-	denotes	(
T11506	44194-44197	VB	denotes	see
T11507	44198-44203	RB	denotes	above
T11508	44203-44204	-RRB-	denotes	)
T11509	44204-44205	.	denotes	.
T11510	44205-44535	sentence	denotes	Species abbreviations are as follows: hs (Homo sapiens), mm (Mus musculus), rn (Rattus norvegus), oc (Oryctolagus cuniculus), gg (Gallus gallus), xl (Xenopus laevis), st (Silurana tropicalis), tr (Takifugu rubripes), dr (Danio rerio), ci (Ciona intestinalis), dm (D. melanogaster), ce (C. elegans), sc (Saccharomyces cerevisiae).
T11511	44206-44213	NN	denotes	Species
T11512	44214-44227	NNS	denotes	abbreviations
T11513	44228-44231	VBP	denotes	are
T11514	44232-44234	IN	denotes	as
T11515	44235-44242	VBZ	denotes	follows
T11516	44242-44244	:	denotes	:
T11517	44244-44246	NNP	denotes	hs
T11518	44247-44248	-LRB-	denotes	(
T11519	44248-44252	NNP	denotes	Homo
T11520	44253-44260	NNP	denotes	sapiens
T11521	44260-44261	-RRB-	denotes	)
T11522	44261-44263	,	denotes	,
T11523	44263-44265	NNP	denotes	mm
T11524	44266-44267	-LRB-	denotes	(
T11525	44267-44270	NNP	denotes	Mus
T11526	44271-44279	NNP	denotes	musculus
T11527	44279-44280	-RRB-	denotes	)
T11528	44280-44282	,	denotes	,
T11529	44282-44284	NNP	denotes	rn
T11530	44285-44286	-LRB-	denotes	(
T11531	44286-44292	NNP	denotes	Rattus
T11532	44293-44301	NNP	denotes	norvegus
T11533	44301-44302	-RRB-	denotes	)
T11534	44302-44304	,	denotes	,
T11535	44304-44306	NNP	denotes	oc
T11536	44307-44308	-LRB-	denotes	(
T11537	44308-44319	NNP	denotes	Oryctolagus
T11538	44320-44329	NNP	denotes	cuniculus
T11539	44329-44330	-RRB-	denotes	)
T11540	44330-44332	,	denotes	,
T11541	44332-44334	NNP	denotes	gg
T11542	44335-44336	-LRB-	denotes	(
T11543	44336-44342	NNP	denotes	Gallus
T11544	44343-44349	NNP	denotes	gallus
T11545	44349-44350	-RRB-	denotes	)
T11546	44350-44352	,	denotes	,
T11547	44352-44354	NNP	denotes	xl
T11548	44355-44356	-LRB-	denotes	(
T11549	44356-44363	NNP	denotes	Xenopus
T11550	44364-44370	NNP	denotes	laevis
T11551	44370-44371	-RRB-	denotes	)
T11552	44371-44373	,	denotes	,
T11553	44373-44375	NNP	denotes	st
T11554	44376-44377	-LRB-	denotes	(
T11555	44377-44385	NNP	denotes	Silurana
T11556	44386-44396	NNP	denotes	tropicalis
T11557	44396-44397	-RRB-	denotes	)
T11558	44397-44399	,	denotes	,
T11559	44399-44401	NNP	denotes	tr
T11560	44402-44403	-LRB-	denotes	(
T11561	44403-44411	NNP	denotes	Takifugu
T11562	44412-44420	NNP	denotes	rubripes
T11563	44420-44421	-RRB-	denotes	)
T11564	44421-44423	,	denotes	,
T11565	44423-44425	NNP	denotes	dr
T11566	44426-44427	-LRB-	denotes	(
T11567	44427-44432	NNP	denotes	Danio
T11568	44433-44438	NNP	denotes	rerio
T11569	44438-44439	-RRB-	denotes	)
T11570	44439-44441	,	denotes	,
T11571	44441-44443	NNP	denotes	ci
T11572	44444-44445	-LRB-	denotes	(
T11573	44445-44450	NNP	denotes	Ciona
T11574	44451-44463	NNP	denotes	intestinalis
T11575	44463-44464	-RRB-	denotes	)
T11576	44464-44466	,	denotes	,
T11577	44466-44468	NN	denotes	dm
T11578	44469-44470	-LRB-	denotes	(
T11579	44470-44472	NNP	denotes	D.
T11580	44473-44485	NNP	denotes	melanogaster
T11581	44485-44486	-RRB-	denotes	)
T11582	44486-44488	,	denotes	,
T11583	44488-44490	NNP	denotes	ce
T11584	44491-44492	-LRB-	denotes	(
T11585	44492-44494	NNP	denotes	C.
T11586	44495-44502	NNP	denotes	elegans
T11587	44502-44503	-RRB-	denotes	)
T11588	44503-44505	,	denotes	,
T11589	44505-44507	NNP	denotes	sc
T11590	44508-44509	-LRB-	denotes	(
T11591	44509-44522	NNP	denotes	Saccharomyces
T11592	44523-44533	NNP	denotes	cerevisiae
T11593	44533-44534	-RRB-	denotes	)
T11594	44534-44535	.	denotes	.
T11595	44535-45503	sentence	denotes	The sequences identified above and the following protein or predicted translations were used for phylogenetic analysis: hsTACC1A (NP_006274), hsTACC2l (AAO62630) hsTACC2s (AAO62629), hsTACC3 (NP_006333), mmTACC3 (Q9JJ11), xlMaskin (Q9PTG8), dmTACC (AAF52099), ceTAC1 (NP_497059), scSPC72 (NP_009352), hsRHAMM (NP_036616), mmRHAMM (NP_038580), rnRHAMM (NP_037096), drRHAMM (AAQ97980), hsKeratin (CAB76828), mmKeratin (A61368), rnKeratin (XP_235679), hsTPM1 (NP_000357), mmTPM1 (NP_077745), rnTPM1 (NP_62004, drTPM1 (NP_571180) dmTPM1 (P06754), ceTPM (NP_493540) scTPM1 (P17536), hsKLP2 (BAB03309), rnKIF15 (AAP44513), xlKLP2 (CAA08879), dmKLP2 (NP_476818), ceKLP18 (AA034669), hsKIF3A (Q9Y496), mmKIF3A (NP_032469), rnKIF3A (XP_340797), xlKIF3A (CAA08879), ceKLP11 (NP_741473), ciKIF3 (ci0100148992), hsKIF3B (NP_004789), mmKIF3B (NP_004789), rnKIF3B (XP_215883), dmKIF3B (NP_524029), hsKIF3C (NP_002245), mmKIF3C (NP_032471), rnKIF3C (NP_445938), dmKIF3C (NP_651939).
T11596	44536-44539	DT	denotes	The
T11597	44540-44549	NNS	denotes	sequences
T11599	44550-44560	VBN	denotes	identified
T11600	44561-44566	RB	denotes	above
T11601	44567-44570	CC	denotes	and
T11602	44571-44574	DT	denotes	the
T11604	44575-44584	VBG	denotes	following
T11605	44585-44592	NN	denotes	protein
T11606	44593-44595	CC	denotes	or
T11607	44596-44605	VBN	denotes	predicted
T11603	44606-44618	NNS	denotes	translations
T11608	44619-44623	VBD	denotes	were
T11598	44624-44628	VBN	denotes	used
T11609	44629-44632	IN	denotes	for
T11610	44633-44645	JJ	denotes	phylogenetic
T11611	44646-44654	NN	denotes	analysis
T11612	44654-44656	:	denotes	:
T11613	44656-44664	NN	denotes	hsTACC1A
T11614	44665-44666	-LRB-	denotes	(
T11615	44666-44675	NN	denotes	NP_006274
T11616	44675-44676	-RRB-	denotes	)
T11617	44676-44678	,	denotes	,
T11618	44678-44686	NN	denotes	hsTACC2l
T11619	44687-44688	-LRB-	denotes	(
T11620	44688-44696	NN	denotes	AAO62630
T11621	44696-44697	-RRB-	denotes	)
T11622	44698-44706	NN	denotes	hsTACC2s
T11623	44707-44708	-LRB-	denotes	(
T11624	44708-44716	NN	denotes	AAO62629
T11625	44716-44717	-RRB-	denotes	)
T11626	44717-44719	,	denotes	,
T11627	44719-44726	NN	denotes	hsTACC3
T11628	44727-44728	-LRB-	denotes	(
T11629	44728-44737	NN	denotes	NP_006333
T11630	44737-44738	-RRB-	denotes	)
T11631	44738-44740	,	denotes	,
T11632	44740-44747	NN	denotes	mmTACC3
T11633	44748-44749	-LRB-	denotes	(
T11634	44749-44755	NN	denotes	Q9JJ11
T11635	44755-44756	-RRB-	denotes	)
T11636	44756-44758	,	denotes	,
T11637	44758-44766	NN	denotes	xlMaskin
T11638	44767-44768	-LRB-	denotes	(
T11639	44768-44774	NN	denotes	Q9PTG8
T11640	44774-44775	-RRB-	denotes	)
T11641	44775-44777	,	denotes	,
T11642	44777-44783	NN	denotes	dmTACC
T11643	44784-44785	-LRB-	denotes	(
T11644	44785-44793	NN	denotes	AAF52099
T11645	44793-44794	-RRB-	denotes	)
T11646	44794-44796	,	denotes	,
T11647	44796-44802	NN	denotes	ceTAC1
T11648	44803-44804	-LRB-	denotes	(
T11649	44804-44813	NN	denotes	NP_497059
T11650	44813-44814	-RRB-	denotes	)
T11651	44814-44816	,	denotes	,
T11652	44816-44823	NN	denotes	scSPC72
T11653	44824-44825	-LRB-	denotes	(
T11654	44825-44834	NN	denotes	NP_009352
T11655	44834-44835	-RRB-	denotes	)
T11656	44835-44837	,	denotes	,
T11657	44837-44844	NN	denotes	hsRHAMM
T11658	44845-44846	-LRB-	denotes	(
T11659	44846-44855	NN	denotes	NP_036616
T11660	44855-44856	-RRB-	denotes	)
T11661	44856-44858	,	denotes	,
T11662	44858-44865	NN	denotes	mmRHAMM
T11663	44866-44867	-LRB-	denotes	(
T11664	44867-44876	NN	denotes	NP_038580
T11665	44876-44877	-RRB-	denotes	)
T11666	44877-44879	,	denotes	,
T11667	44879-44886	NN	denotes	rnRHAMM
T11668	44887-44888	-LRB-	denotes	(
T11669	44888-44897	NN	denotes	NP_037096
T11670	44897-44898	-RRB-	denotes	)
T11671	44898-44900	,	denotes	,
T11672	44900-44907	NN	denotes	drRHAMM
T11673	44908-44909	-LRB-	denotes	(
T11674	44909-44917	NN	denotes	AAQ97980
T11675	44917-44918	-RRB-	denotes	)
T11676	44918-44920	,	denotes	,
T11677	44920-44929	NN	denotes	hsKeratin
T11678	44930-44931	-LRB-	denotes	(
T11679	44931-44939	NN	denotes	CAB76828
T11680	44939-44940	-RRB-	denotes	)
T11681	44940-44942	,	denotes	,
T11682	44942-44951	NN	denotes	mmKeratin
T11683	44952-44953	-LRB-	denotes	(
T11684	44953-44959	NN	denotes	A61368
T11685	44959-44960	-RRB-	denotes	)
T11686	44960-44962	,	denotes	,
T11687	44962-44971	NN	denotes	rnKeratin
T11688	44972-44973	-LRB-	denotes	(
T11689	44973-44982	NN	denotes	XP_235679
T11690	44982-44983	-RRB-	denotes	)
T11691	44983-44985	,	denotes	,
T11692	44985-44991	NN	denotes	hsTPM1
T11693	44992-44993	-LRB-	denotes	(
T11694	44993-45002	NN	denotes	NP_000357
T11695	45002-45003	-RRB-	denotes	)
T11696	45003-45005	,	denotes	,
T11697	45005-45011	NN	denotes	mmTPM1
T11698	45012-45013	-LRB-	denotes	(
T11699	45013-45022	NN	denotes	NP_077745
T11700	45022-45023	-RRB-	denotes	)
T11701	45023-45025	,	denotes	,
T11702	45025-45031	NN	denotes	rnTPM1
T11703	45032-45033	-LRB-	denotes	(
T11704	45033-45041	NN	denotes	NP_62004
T11705	45041-45043	,	denotes	,
T11706	45043-45049	NN	denotes	drTPM1
T11707	45050-45051	-LRB-	denotes	(
T11708	45051-45060	NN	denotes	NP_571180
T11709	45060-45061	-RRB-	denotes	)
T11710	45062-45068	NN	denotes	dmTPM1
T11711	45069-45070	-LRB-	denotes	(
T11712	45070-45076	NN	denotes	P06754
T11713	45076-45077	-RRB-	denotes	)
T11714	45077-45079	,	denotes	,
T11715	45079-45084	NN	denotes	ceTPM
T11716	45085-45086	-LRB-	denotes	(
T11717	45086-45095	NN	denotes	NP_493540
T11718	45095-45096	-RRB-	denotes	)
T11719	45097-45103	NN	denotes	scTPM1
T11720	45104-45105	-LRB-	denotes	(
T11721	45105-45111	NN	denotes	P17536
T11722	45111-45112	-RRB-	denotes	)
T11723	45112-45114	,	denotes	,
T11724	45114-45120	NN	denotes	hsKLP2
T11725	45121-45122	-LRB-	denotes	(
T11726	45122-45130	NN	denotes	BAB03309
T11727	45130-45131	-RRB-	denotes	)
T11728	45131-45133	,	denotes	,
T11729	45133-45140	NN	denotes	rnKIF15
T11730	45141-45142	-LRB-	denotes	(
T11731	45142-45150	NN	denotes	AAP44513
T11732	45150-45151	-RRB-	denotes	)
T11733	45151-45153	,	denotes	,
T11734	45153-45159	NN	denotes	xlKLP2
T11735	45160-45161	-LRB-	denotes	(
T11736	45161-45169	NN	denotes	CAA08879
T11737	45169-45170	-RRB-	denotes	)
T11738	45170-45172	,	denotes	,
T11739	45172-45178	NN	denotes	dmKLP2
T11740	45179-45180	-LRB-	denotes	(
T11741	45180-45189	NN	denotes	NP_476818
T11742	45189-45190	-RRB-	denotes	)
T11743	45190-45192	,	denotes	,
T11744	45192-45199	NN	denotes	ceKLP18
T11745	45200-45201	-LRB-	denotes	(
T11746	45201-45209	NN	denotes	AA034669
T11747	45209-45210	-RRB-	denotes	)
T11748	45210-45212	,	denotes	,
T11749	45212-45219	NN	denotes	hsKIF3A
T11750	45220-45221	-LRB-	denotes	(
T11751	45221-45227	NN	denotes	Q9Y496
T11752	45227-45228	-RRB-	denotes	)
T11753	45228-45230	,	denotes	,
T11754	45230-45237	NN	denotes	mmKIF3A
T11755	45238-45239	-LRB-	denotes	(
T11756	45239-45248	NN	denotes	NP_032469
T11757	45248-45249	-RRB-	denotes	)
T11758	45249-45251	,	denotes	,
T11759	45251-45258	NN	denotes	rnKIF3A
T11760	45259-45260	-LRB-	denotes	(
T11761	45260-45269	NN	denotes	XP_340797
T11762	45269-45270	-RRB-	denotes	)
T11763	45270-45272	,	denotes	,
T11764	45272-45279	NN	denotes	xlKIF3A
T11765	45280-45281	-LRB-	denotes	(
T11766	45281-45289	NN	denotes	CAA08879
T11767	45289-45290	-RRB-	denotes	)
T11768	45290-45292	,	denotes	,
T11769	45292-45299	NN	denotes	ceKLP11
T11770	45300-45301	-LRB-	denotes	(
T11771	45301-45310	NN	denotes	NP_741473
T11772	45310-45311	-RRB-	denotes	)
T11773	45311-45313	,	denotes	,
T11774	45313-45319	NN	denotes	ciKIF3
T11775	45320-45321	-LRB-	denotes	(
T11776	45321-45333	NN	denotes	ci0100148992
T11777	45333-45334	-RRB-	denotes	)
T11778	45334-45336	,	denotes	,
T11779	45336-45343	NN	denotes	hsKIF3B
T11780	45344-45345	-LRB-	denotes	(
T11781	45345-45354	NN	denotes	NP_004789
T11782	45354-45355	-RRB-	denotes	)
T11783	45355-45357	,	denotes	,
T11784	45357-45364	NN	denotes	mmKIF3B
T11785	45365-45366	-LRB-	denotes	(
T11786	45366-45375	NN	denotes	NP_004789
T11787	45375-45376	-RRB-	denotes	)
T11788	45376-45378	,	denotes	,
T11789	45378-45385	NN	denotes	rnKIF3B
T11790	45386-45387	-LRB-	denotes	(
T11791	45387-45396	NN	denotes	XP_215883
T11792	45396-45397	-RRB-	denotes	)
T11793	45397-45399	,	denotes	,
T11794	45399-45406	NN	denotes	dmKIF3B
T11795	45407-45408	-LRB-	denotes	(
T11796	45408-45417	NN	denotes	NP_524029
T11797	45417-45418	-RRB-	denotes	)
T11798	45418-45420	,	denotes	,
T11799	45420-45427	NN	denotes	hsKIF3C
T11800	45428-45429	-LRB-	denotes	(
T11801	45429-45438	NN	denotes	NP_002245
T11802	45438-45439	-RRB-	denotes	)
T11803	45439-45441	,	denotes	,
T11804	45441-45448	NN	denotes	mmKIF3C
T11805	45449-45450	-LRB-	denotes	(
T11806	45450-45459	NN	denotes	NP_032471
T11807	45459-45460	-RRB-	denotes	)
T11808	45460-45462	,	denotes	,
T11809	45462-45469	NN	denotes	rnKIF3C
T11810	45470-45471	-LRB-	denotes	(
T11811	45471-45480	NN	denotes	NP_445938
T11812	45480-45481	-RRB-	denotes	)
T11813	45481-45483	,	denotes	,
T11814	45483-45490	NN	denotes	dmKIF3C
T11815	45491-45492	-LRB-	denotes	(
T11816	45492-45501	NN	denotes	NP_651939
T11817	45501-45502	-RRB-	denotes	)
T11818	45502-45503	.	denotes	.
T11819	45503-45571	sentence	denotes	These protein sequences were initially aligned with CLUSTAL X [38].
T11820	45504-45509	DT	denotes	These
T11822	45510-45517	NN	denotes	protein
T11821	45518-45527	NNS	denotes	sequences
T11824	45528-45532	VBD	denotes	were
T11825	45533-45542	RB	denotes	initially
T11823	45543-45550	VBN	denotes	aligned
T11826	45551-45555	IN	denotes	with
T11827	45556-45563	NNP	denotes	CLUSTAL
T11828	45564-45565	NNP	denotes	X
T11829	45566-45567	-LRB-	denotes	[
T11830	45567-45569	CD	denotes	38
T11831	45569-45570	-RRB-	denotes	]
T11832	45570-45571	.	denotes	.
T11833	45571-45907	sentence	denotes	Minor adjustments to certain regions of the alignment for optimization purposes were made based on pairwise alignments, the output saved in PHYLIP format, after which, the distances between proteins were calculated using Poisson correction and the Unrooted trees were inferred with the NJ method and then displayed using TreeView [39].
T11834	45572-45577	JJ	denotes	Minor
T11835	45578-45589	NNS	denotes	adjustments
T11837	45590-45592	IN	denotes	to
T11838	45593-45600	JJ	denotes	certain
T11839	45601-45608	NNS	denotes	regions
T11840	45609-45611	IN	denotes	of
T11841	45612-45615	DT	denotes	the
T11842	45616-45625	NN	denotes	alignment
T11843	45626-45629	IN	denotes	for
T11844	45630-45642	NN	denotes	optimization
T11845	45643-45651	NNS	denotes	purposes
T11846	45652-45656	VBD	denotes	were
T11836	45657-45661	VBN	denotes	made
T11848	45662-45667	VBN	denotes	based
T11849	45668-45670	IN	denotes	on
T11850	45671-45679	JJ	denotes	pairwise
T11851	45680-45690	NNS	denotes	alignments
T11852	45690-45692	,	denotes	,
T11853	45692-45695	DT	denotes	the
T11854	45696-45702	NN	denotes	output
T11847	45703-45708	VBD	denotes	saved
T11855	45709-45711	IN	denotes	in
T11856	45712-45718	NN	denotes	PHYLIP
T11857	45719-45725	NN	denotes	format
T11858	45725-45727	,	denotes	,
T11859	45727-45732	IN	denotes	after
T11861	45733-45738	WDT	denotes	which
T11862	45738-45740	,	denotes	,
T11863	45740-45743	DT	denotes	the
T11864	45744-45753	NNS	denotes	distances
T11865	45754-45761	IN	denotes	between
T11866	45762-45770	NN	denotes	proteins
T11867	45771-45775	VBD	denotes	were
T11860	45776-45786	VBN	denotes	calculated
T11868	45787-45792	VBG	denotes	using
T11869	45793-45800	NNP	denotes	Poisson
T11870	45801-45811	NN	denotes	correction
T11871	45812-45815	CC	denotes	and
T11872	45816-45819	DT	denotes	the
T11874	45820-45828	JJ	denotes	Unrooted
T11873	45829-45834	NNS	denotes	trees
T11876	45835-45839	VBD	denotes	were
T11875	45840-45848	VBN	denotes	inferred
T11877	45849-45853	IN	denotes	with
T11878	45854-45857	DT	denotes	the
T11880	45858-45860	NN	denotes	NJ
T11879	45861-45867	NN	denotes	method
T11881	45868-45871	CC	denotes	and
T11882	45872-45876	RB	denotes	then
T11883	45877-45886	VBD	denotes	displayed
T11884	45887-45892	VBG	denotes	using
T11885	45893-45901	NNP	denotes	TreeView
T11886	45902-45903	-LRB-	denotes	[
T11887	45903-45905	CD	denotes	39
T11888	45905-45906	-RRB-	denotes	]
T11889	45906-45907	.	denotes	.
T11890	45907-45973	sentence	denotes	Bootstrap values above 700 for 1000 trials are shown at the node.
T11891	45908-45917	NN	denotes	Bootstrap
T11892	45918-45924	NNS	denotes	values
T11894	45925-45930	IN	denotes	above
T11895	45931-45934	CD	denotes	700
T11896	45935-45938	IN	denotes	for
T11897	45939-45943	CD	denotes	1000
T11898	45944-45950	NNS	denotes	trials
T11899	45951-45954	VBP	denotes	are
T11893	45955-45960	VBN	denotes	shown
T11900	45961-45963	IN	denotes	at
T11901	45964-45967	DT	denotes	the
T11902	45968-45972	NN	denotes	node
T11903	45972-45973	.	denotes	.
T11904	45973-46149	sentence	denotes	To validate the tree, the same sequence set was analyzed with tools in the PHYLIP package [40], using PRODIST followed by FITCH or NEIGNBOR and tree displaying using TreeView.
T11905	45974-45976	TO	denotes	To
T11906	45977-45985	VB	denotes	validate
T11908	45986-45989	DT	denotes	the
T11909	45990-45994	NN	denotes	tree
T11910	45994-45996	,	denotes	,
T11911	45996-45999	DT	denotes	the
T11913	46000-46004	JJ	denotes	same
T11914	46005-46013	NN	denotes	sequence
T11912	46014-46017	NN	denotes	set
T11915	46018-46021	VBD	denotes	was
T11907	46022-46030	VBN	denotes	analyzed
T11916	46031-46035	IN	denotes	with
T11917	46036-46041	NNS	denotes	tools
T11918	46042-46044	IN	denotes	in
T11919	46045-46048	DT	denotes	the
T11921	46049-46055	NN	denotes	PHYLIP
T11920	46056-46063	NN	denotes	package
T11922	46064-46065	-LRB-	denotes	[
T11923	46065-46067	CD	denotes	40
T11924	46067-46068	-RRB-	denotes	]
T11925	46068-46070	,	denotes	,
T11926	46070-46075	VBG	denotes	using
T11927	46076-46083	NN	denotes	PRODIST
T11928	46084-46092	VBN	denotes	followed
T11929	46093-46095	IN	denotes	by
T11930	46096-46101	NN	denotes	FITCH
T11931	46102-46104	CC	denotes	or
T11932	46105-46113	NN	denotes	NEIGNBOR
T11933	46114-46117	CC	denotes	and
T11934	46118-46122	NN	denotes	tree
T11935	46123-46133	VBG	denotes	displaying
T11936	46134-46139	VBG	denotes	using
T11937	46140-46148	NNP	denotes	TreeView
T11938	46148-46149	.	denotes	.
T11939	46149-46240	sentence	denotes	This additional method produced trees with essentially the same topology (data not shown).
T11940	46150-46154	DT	denotes	This
T11942	46155-46165	JJ	denotes	additional
T11941	46166-46172	NN	denotes	method
T11943	46173-46181	VBD	denotes	produced
T11944	46182-46187	NNS	denotes	trees
T11945	46188-46192	IN	denotes	with
T11946	46193-46204	RB	denotes	essentially
T11948	46205-46208	DT	denotes	the
T11949	46209-46213	JJ	denotes	same
T11947	46214-46222	NN	denotes	topology
T11950	46223-46224	-LRB-	denotes	(
T11952	46224-46228	NNS	denotes	data
T11953	46229-46232	RB	denotes	not
T11951	46233-46238	VBN	denotes	shown
T11954	46238-46239	-RRB-	denotes	)
T11955	46239-46240	.	denotes	.
T12120	46242-46244	FW	denotes	In
T12121	46245-46250	FW	denotes	vitro
T12122	46251-46262	NN	denotes	interaction
T12123	46263-46265	IN	denotes	of
T12124	46266-46271	NN	denotes	TACC2
T12125	46272-46275	CC	denotes	and
T12126	46276-46281	NN	denotes	RXRβ3
T12127	46281-46383	sentence	denotes	The TACC2 cDNA was cloned into GST fusion vector pGEX5X2 (Amersham Biosciences, Piscataway, NJ, USA).
T12128	46282-46285	DT	denotes	The
T12130	46286-46291	NN	denotes	TACC2
T12129	46292-46296	NN	denotes	cDNA
T12132	46297-46300	VBD	denotes	was
T12131	46301-46307	VBN	denotes	cloned
T12133	46308-46312	IN	denotes	into
T12134	46313-46316	NN	denotes	GST
T12136	46317-46323	NN	denotes	fusion
T12137	46324-46330	NN	denotes	vector
T12135	46331-46338	NN	denotes	pGEX5X2
T12138	46339-46340	-LRB-	denotes	(
T12140	46340-46348	NNP	denotes	Amersham
T12139	46349-46360	NNP	denotes	Biosciences
T12141	46360-46362	,	denotes	,
T12142	46362-46372	NNP	denotes	Piscataway
T12143	46372-46374	,	denotes	,
T12144	46374-46376	NNP	denotes	NJ
T12145	46376-46378	,	denotes	,
T12146	46378-46381	NNP	denotes	USA
T12147	46381-46382	-RRB-	denotes	)
T12148	46382-46383	.	denotes	.
T12149	46383-46496	sentence	denotes	GST and GST-TACC2 proteins were expressed in E. coli BL21(DE3) plys "S" with 1 mM IPTG at 37°C shaker for 2 hrs.
T12150	46384-46387	NN	denotes	GST
T12152	46388-46391	CC	denotes	and
T12153	46392-46395	NN	denotes	GST
T12155	46395-46396	HYPH	denotes	-
T12154	46396-46401	NN	denotes	TACC2
T12151	46402-46410	NN	denotes	proteins
T12157	46411-46415	VBD	denotes	were
T12156	46416-46425	VBN	denotes	expressed
T12158	46426-46428	IN	denotes	in
T12159	46429-46431	NNP	denotes	E.
T12160	46432-46436	NNP	denotes	coli
T12162	46437-46441	NN	denotes	BL21
T12163	46441-46442	-LRB-	denotes	(
T12164	46442-46445	NN	denotes	DE3
T12165	46445-46446	-RRB-	denotes	)
T12166	46447-46451	NNS	denotes	plys
T12167	46452-46453	``	denotes	"
T12161	46453-46454	NN	denotes	S
T12168	46454-46455	''	denotes	"
T12169	46456-46460	IN	denotes	with
T12170	46461-46462	CD	denotes	1
T12171	46463-46465	NN	denotes	mM
T12172	46466-46470	NN	denotes	IPTG
T12173	46471-46473	IN	denotes	at
T12174	46474-46476	CD	denotes	37
T12175	46476-46478	NN	denotes	°C
T12176	46479-46485	NN	denotes	shaker
T12177	46486-46489	IN	denotes	for
T12178	46490-46491	CD	denotes	2
T12179	46492-46495	NNS	denotes	hrs
T12180	46495-46496	.	denotes	.
T12181	46496-46646	sentence	denotes	Cells (50 ml) were harvested and resuspended in 5 ml of 20 mM Tris-HCl pH.8.0, 200 mM NaCl, 1 mM EDTA pH8.0, Protease inhibitor set III (Calbiochem).
T12182	46497-46502	NNS	denotes	Cells
T12184	46503-46504	-LRB-	denotes	(
T12186	46504-46506	CD	denotes	50
T12185	46507-46509	NN	denotes	ml
T12187	46509-46510	-RRB-	denotes	)
T12188	46511-46515	VBD	denotes	were
T12183	46516-46525	VBN	denotes	harvested
T12189	46526-46529	CC	denotes	and
T12190	46530-46541	VBN	denotes	resuspended
T12191	46542-46544	IN	denotes	in
T12192	46545-46546	CD	denotes	5
T12193	46547-46549	NN	denotes	ml
T12194	46550-46552	IN	denotes	of
T12195	46553-46555	CD	denotes	20
T12196	46556-46558	NN	denotes	mM
T12198	46559-46563	NN	denotes	Tris
T12199	46563-46564	HYPH	denotes	-
T12197	46564-46567	NN	denotes	HCl
T12200	46568-46574	NN	denotes	pH.8.0
T12201	46574-46576	,	denotes	,
T12202	46576-46579	CD	denotes	200
T12203	46580-46582	NN	denotes	mM
T12204	46583-46587	NN	denotes	NaCl
T12205	46587-46589	,	denotes	,
T12206	46589-46590	CD	denotes	1
T12207	46591-46593	NN	denotes	mM
T12208	46594-46598	NN	denotes	EDTA
T12209	46599-46604	NN	denotes	pH8.0
T12210	46604-46606	,	denotes	,
T12211	46606-46614	NN	denotes	Protease
T12212	46615-46624	NN	denotes	inhibitor
T12213	46625-46628	NN	denotes	set
T12214	46629-46632	CD	denotes	III
T12215	46633-46634	-LRB-	denotes	(
T12216	46634-46644	NNP	denotes	Calbiochem
T12217	46644-46645	-RRB-	denotes	)
T12218	46645-46646	.	denotes	.
T12219	46646-46749	sentence	denotes	The cells were lysed by sonication and lysate cleared by centrifugation at 7500 rpm at 4°C for 15 min.
T12220	46647-46650	DT	denotes	The
T12221	46651-46656	NNS	denotes	cells
T12223	46657-46661	VBD	denotes	were
T12222	46662-46667	VBN	denotes	lysed
T12224	46668-46670	IN	denotes	by
T12225	46671-46681	NN	denotes	sonication
T12226	46682-46685	CC	denotes	and
T12227	46686-46692	NN	denotes	lysate
T12228	46693-46700	VBN	denotes	cleared
T12229	46701-46703	IN	denotes	by
T12230	46704-46718	NN	denotes	centrifugation
T12231	46719-46721	IN	denotes	at
T12232	46722-46726	CD	denotes	7500
T12233	46727-46730	NN	denotes	rpm
T12234	46731-46733	IN	denotes	at
T12235	46734-46735	CD	denotes	4
T12236	46735-46737	NN	denotes	°C
T12237	46738-46741	IN	denotes	for
T12238	46742-46744	CD	denotes	15
T12239	46745-46748	NN	denotes	min
T12240	46748-46749	.	denotes	.
T12241	46749-46880	sentence	denotes	The cleared lysate was immobilized on glutathione sepharose beads in 3 ml of 20 mM Tris-HCl pH.8.0, 200 mM NaCl, 1 mM EDTA pH8.0).
T12242	46750-46753	DT	denotes	The
T12244	46754-46761	JJ	denotes	cleared
T12243	46762-46768	NN	denotes	lysate
T12246	46769-46772	VBD	denotes	was
T12245	46773-46784	VBN	denotes	immobilized
T12247	46785-46787	IN	denotes	on
T12248	46788-46799	NN	denotes	glutathione
T12249	46800-46809	NN	denotes	sepharose
T12250	46810-46815	NNS	denotes	beads
T12251	46816-46818	IN	denotes	in
T12252	46819-46820	CD	denotes	3
T12253	46821-46823	NN	denotes	ml
T12254	46824-46826	IN	denotes	of
T12255	46827-46829	CD	denotes	20
T12256	46830-46832	NN	denotes	mM
T12258	46833-46837	NN	denotes	Tris
T12259	46837-46838	HYPH	denotes	-
T12257	46838-46841	NN	denotes	HCl
T12260	46842-46848	NN	denotes	pH.8.0
T12261	46848-46850	,	denotes	,
T12262	46850-46853	CD	denotes	200
T12263	46854-46856	NN	denotes	mM
T12264	46857-46861	NN	denotes	NaCl
T12265	46861-46863	,	denotes	,
T12266	46863-46864	CD	denotes	1
T12267	46865-46867	NN	denotes	mM
T12268	46868-46872	NN	denotes	EDTA
T12269	46873-46878	NN	denotes	pH8.0
T12270	46878-46879	-RRB-	denotes	)
T12271	46879-46880	.	denotes	.
T12272	46880-47121	sentence	denotes	RXRβ3 cDNA was cloned into pET 28C(+) (Invitrogen, Carlsbad, CA, USA) and protein synthesized by TNT quick coupled transcription/translation system kit (Promega) and radiolabeled with 35S methionine according to manufacturer's instructions.
T12273	46881-46886	NN	denotes	RXRβ3
T12274	46887-46891	NN	denotes	cDNA
T12276	46892-46895	VBD	denotes	was
T12275	46896-46902	VBN	denotes	cloned
T12277	46903-46907	IN	denotes	into
T12278	46908-46911	NN	denotes	pET
T12279	46912-46915	NN	denotes	28C
T12280	46915-46916	-LRB-	denotes	(
T12281	46916-46917	SYM	denotes	+
T12282	46917-46918	-RRB-	denotes	)
T12283	46919-46920	-LRB-	denotes	(
T12284	46920-46930	NNP	denotes	Invitrogen
T12285	46930-46932	,	denotes	,
T12286	46932-46940	NNP	denotes	Carlsbad
T12287	46940-46942	,	denotes	,
T12288	46942-46944	NNP	denotes	CA
T12289	46944-46946	,	denotes	,
T12290	46946-46949	NNP	denotes	USA
T12291	46949-46950	-RRB-	denotes	)
T12292	46951-46954	CC	denotes	and
T12293	46955-46962	NN	denotes	protein
T12294	46963-46974	VBN	denotes	synthesized
T12295	46975-46977	IN	denotes	by
T12296	46978-46981	NN	denotes	TNT
T12298	46982-46987	RB	denotes	quick
T12299	46988-46995	VBN	denotes	coupled
T12300	46996-47009	NN	denotes	transcription
T12302	47009-47010	HYPH	denotes	/
T12301	47010-47021	NN	denotes	translation
T12303	47022-47028	NN	denotes	system
T12297	47029-47032	NN	denotes	kit
T12304	47033-47034	-LRB-	denotes	(
T12305	47034-47041	NNP	denotes	Promega
T12306	47041-47042	-RRB-	denotes	)
T12307	47043-47046	CC	denotes	and
T12308	47047-47059	VBN	denotes	radiolabeled
T12309	47060-47064	IN	denotes	with
T12310	47065-47068	NN	denotes	35S
T12311	47069-47079	NN	denotes	methionine
T12312	47080-47089	VBG	denotes	according
T12313	47090-47092	IN	denotes	to
T12314	47093-47105	NN	denotes	manufacturer
T12316	47105-47107	POS	denotes	's
T12315	47108-47120	NNS	denotes	instructions
T12317	47120-47121	.	denotes	.
T12318	47121-47295	sentence	denotes	100 μl of in vitro translated RXRβ3 protein in 1 ml of 20 mM Tris-HCl pH.8.0, 200 mM NaCl, 1 mM EDTA pH8.0 was incubated at 4°C with immobilized GST-TACC2 or GST for 90 min.
T12319	47122-47125	CD	denotes	100
T12320	47126-47128	NN	denotes	μl
T12322	47129-47131	IN	denotes	of
T12323	47132-47134	FW	denotes	in
T12324	47135-47140	FW	denotes	vitro
T12325	47141-47151	VBN	denotes	translated
T12327	47152-47157	NN	denotes	RXRβ3
T12326	47158-47165	NN	denotes	protein
T12328	47166-47168	IN	denotes	in
T12329	47169-47170	CD	denotes	1
T12330	47171-47173	NN	denotes	ml
T12331	47174-47176	IN	denotes	of
T12332	47177-47179	CD	denotes	20
T12333	47180-47182	NN	denotes	mM
T12335	47183-47187	NN	denotes	Tris
T12336	47187-47188	HYPH	denotes	-
T12334	47188-47191	NN	denotes	HCl
T12337	47192-47198	NN	denotes	pH.8.0
T12338	47198-47200	,	denotes	,
T12339	47200-47203	CD	denotes	200
T12340	47204-47206	NN	denotes	mM
T12341	47207-47211	NN	denotes	NaCl
T12342	47211-47213	,	denotes	,
T12343	47213-47214	CD	denotes	1
T12344	47215-47217	NN	denotes	mM
T12345	47218-47222	NN	denotes	EDTA
T12346	47223-47228	NN	denotes	pH8.0
T12347	47229-47232	VBD	denotes	was
T12321	47233-47242	VBN	denotes	incubated
T12348	47243-47245	IN	denotes	at
T12349	47246-47247	CD	denotes	4
T12350	47247-47249	NN	denotes	°C
T12351	47250-47254	IN	denotes	with
T12352	47255-47266	VBN	denotes	immobilized
T12354	47267-47270	NN	denotes	GST
T12355	47270-47271	HYPH	denotes	-
T12353	47271-47276	NN	denotes	TACC2
T12356	47277-47279	CC	denotes	or
T12357	47280-47283	NN	denotes	GST
T12358	47284-47287	IN	denotes	for
T12359	47288-47290	CD	denotes	90
T12360	47291-47294	NN	denotes	min
T12361	47294-47295	.	denotes	.
T12362	47295-47402	sentence	denotes	Unbound RXRβ3 was removed by washing three times with 20 mM Tris-HCl pH.8.0, 200 mM NaCl, 1 mM EDTA pH8.0.
T12363	47296-47303	JJ	denotes	Unbound
T12364	47304-47309	NN	denotes	RXRβ3
T12366	47310-47313	VBD	denotes	was
T12365	47314-47321	VBN	denotes	removed
T12367	47322-47324	IN	denotes	by
T12368	47325-47332	VBG	denotes	washing
T12369	47333-47338	CD	denotes	three
T12370	47339-47344	NNS	denotes	times
T12371	47345-47349	IN	denotes	with
T12372	47350-47352	CD	denotes	20
T12373	47353-47355	NN	denotes	mM
T12375	47356-47360	NN	denotes	Tris
T12376	47360-47361	HYPH	denotes	-
T12374	47361-47364	NN	denotes	HCl
T12377	47365-47371	NN	denotes	pH.8.0
T12378	47371-47373	,	denotes	,
T12379	47373-47376	CD	denotes	200
T12380	47377-47379	NN	denotes	mM
T12381	47380-47384	NN	denotes	NaCl
T12382	47384-47386	,	denotes	,
T12383	47386-47387	CD	denotes	1
T12384	47388-47390	NN	denotes	mM
T12385	47391-47395	NN	denotes	EDTA
T12386	47396-47401	NN	denotes	pH8.0
T12387	47401-47402	.	denotes	.
T12388	47402-47546	sentence	denotes	Bound proteins were eluted from the beads at room temperature for 10 min in elution buffer (100 mM Tris HCl, pH8.0, 20 mM reduced glutathione).
T12389	47403-47408	NN	denotes	Bound
T12390	47409-47417	NN	denotes	proteins
T12392	47418-47422	VBD	denotes	were
T12391	47423-47429	VBN	denotes	eluted
T12393	47430-47434	IN	denotes	from
T12394	47435-47438	DT	denotes	the
T12395	47439-47444	NNS	denotes	beads
T12396	47445-47447	IN	denotes	at
T12397	47448-47452	NN	denotes	room
T12398	47453-47464	NN	denotes	temperature
T12399	47465-47468	IN	denotes	for
T12400	47469-47471	CD	denotes	10
T12401	47472-47475	NN	denotes	min
T12402	47476-47478	IN	denotes	in
T12403	47479-47486	NN	denotes	elution
T12404	47487-47493	NN	denotes	buffer
T12405	47494-47495	-LRB-	denotes	(
T12407	47495-47498	CD	denotes	100
T12408	47499-47501	NN	denotes	mM
T12409	47502-47506	NN	denotes	Tris
T12406	47507-47510	NN	denotes	HCl
T12410	47510-47512	,	denotes	,
T12411	47512-47517	NN	denotes	pH8.0
T12412	47517-47519	,	denotes	,
T12413	47519-47521	CD	denotes	20
T12414	47522-47524	NN	denotes	mM
T12416	47525-47532	VBN	denotes	reduced
T12415	47533-47544	NN	denotes	glutathione
T12417	47544-47545	-RRB-	denotes	)
T12418	47545-47546	.	denotes	.
T12419	47546-47605	sentence	denotes	The proteins were analyzed on 12% SDS polyacrylamide gels.
T12420	47547-47550	DT	denotes	The
T12421	47551-47559	NN	denotes	proteins
T12423	47560-47564	VBD	denotes	were
T12422	47565-47573	VBN	denotes	analyzed
T12424	47574-47576	IN	denotes	on
T12425	47577-47579	CD	denotes	12
T12426	47579-47580	NN	denotes	%
T12428	47581-47584	NN	denotes	SDS
T12429	47585-47599	NN	denotes	polyacrylamide
T12427	47600-47604	NNS	denotes	gels
T12430	47604-47605	.	denotes	.
T12431	47605-47675	sentence	denotes	Coomassie blue staining verified equal loading of GST fusion protein.
T12432	47606-47615	NNP	denotes	Coomassie
T12434	47616-47620	JJ	denotes	blue
T12433	47621-47629	NN	denotes	staining
T12435	47630-47638	VBD	denotes	verified
T12436	47639-47644	JJ	denotes	equal
T12437	47645-47652	NN	denotes	loading
T12438	47653-47655	IN	denotes	of
T12439	47656-47659	NN	denotes	GST
T12441	47660-47666	NN	denotes	fusion
T12440	47667-47674	NN	denotes	protein
T12442	47674-47675	.	denotes	.
T12443	47675-47709	sentence	denotes	Dried gels were autoradiographed.
T12444	47676-47681	VBN	denotes	Dried
T12445	47682-47686	NNS	denotes	gels
T12447	47687-47691	VBD	denotes	were
T12446	47692-47708	VBN	denotes	autoradiographed
T12448	47708-47709	.	denotes	.
R1000	T1795	T1794	amod	definitive,sequences
R1001	T1796	T1760	conj	found,made
R1002	T1797	T1794	prep	with,sequences
R1003	T1798	T1799	det	a,domain
R1004	T1799	T1797	pobj	domain,with
R1005	T1800	T1799	amod	defined,domain
R1006	T1801	T1799	compound	TACC,domain
R1007	T1802	T1796	aux	could,found
R1008	T1803	T1796	neg	not,found
R1009	T1804	T1796	auxpass	be,found
R1010	T1805	T1796	prep	in,found
R1011	T1806	T1807	amod	other,organisms
R1012	T1807	T1805	pobj	organisms,in
R1013	T1808	T1807	amod	non-metazoan,organisms
R1014	T1809	T1796	punct	.,found
R1015	T1818	T1819	nsubj	a,s
R1016	T1836	T1835	compound	ra,nch
R1017	T1837	T1835	prep	of,nch
R1018	T1838	T1837	pobj	life,of
R1019	T1839	T1833	punct	", ",identified
R1020	T1840	T1841	det	a,gene
R1021	T1841	T1833	nsubjpass	gene,identified
R1022	T1842	T1841	amod	single,gene
R1023	T1843	T1841	compound	TACC,gene
R1024	T1844	T1833	auxpass	was,identified
R1025	T1845	T1833	prep	in,identified
R1026	T1846	T1847	det	the,genome
R1027	T1847	T1845	pobj	genome,in
R1028	T1848	T1847	prep	of,genome
R1029	T1849	T1850	det	the,urochordate
R1030	T1850	T1848	pobj	urochordate,of
R1031	T1851	T1852	compound	Ciona,intestinalis
R1032	T1852	T1850	appos	intestinalis,urochordate
R1033	T1853	T1854	punct	[,11
R1034	T1854	T1850	parataxis	11,urochordate
R1035	T1855	T1854	punct	],11
R1036	T1856	T1847	punct	", ",genome
R1037	T1857	T1847	cc	and,genome
R1038	T1858	T1859	det	a,sequence
R1039	T1859	T1847	conj	sequence,genome
R1040	T1860	T1859	amod	partial,sequence
R1041	T1861	T1859	compound	TACC,sequence
R1042	T1862	T1859	prep	from,sequence
R1043	T1863	T1864	det	an,analysis
R1044	T1864	T1862	pobj	analysis,from
R1045	T1865	T1864	prep	of,analysis
R1046	T1866	T1867	det	the,database
R1047	T1867	T1865	pobj	database,of
R1048	T1868	T1869	compound	Halocynthia,rortezi
R1049	T1869	T1867	compound	rortezi,database
R1050	T1870	T1867	compound	EST,database
R1051	T1871	T1872	punct	[,12
R1052	T1872	T1864	parataxis	12,analysis
R1053	T1873	T1872	punct	],12
R1054	T1874	T1833	punct	.,identified
R1055	T1876	T1877	nsubj	This,confirms
R1056	T1878	T1879	det	the,assumption
R1057	T1879	T1877	dobj	assumption,confirms
R1058	T1880	T1879	amod	original,assumption
R1059	T1881	T1882	mark	that,was
R1060	T1882	T1879	acl	was,assumption
R1061	T1883	T1884	det	a,gene
R1062	T1884	T1882	nsubj	gene,was
R1063	T1885	T1884	amod	single,gene
R1064	T1886	T1884	compound	TACC,gene
R1065	T1887	T1882	acomp	present,was
R1066	T1888	T1882	prep	in,was
R1067	T1889	T1890	det	the,ancestor
R1068	T1890	T1888	pobj	ancestor,in
R1069	T1891	T1890	compound	chordate,ancestor
R1070	T1892	T1877	punct	.,confirms
R1071	T1894	T1895	det	The,event
R1072	T1895	T1898	nsubjpass	event,suggested
R1073	T1896	T1895	amod	next,event
R1074	T1897	T1895	amod	major,event
R1075	T1899	T1895	prep	in,event
R1076	T1900	T1901	det	the,evolution
R1077	T1901	T1899	pobj	evolution,in
R1078	T1902	T1901	prep	of,evolution
R1079	T1903	T1904	det	the,genome
R1080	T1904	T1902	pobj	genome,of
R1081	T1905	T1904	compound	chordate,genome
R1082	T1906	T1898	aux	has,suggested
R1083	T1907	T1898	auxpass	been,suggested
R1084	T1908	T1909	aux	to,occurred
R1085	T1909	T1898	xcomp	occurred,suggested
R1086	T1910	T1909	aux	have,occurred
R1087	T1911	T1912	quantmod	687,155.7
R1088	T1912	T1914	nummod	155.7,years
R1089	T1913	T1912	punct	±,155.7
R1090	T1914	T1916	npadvmod	years,ago
R1091	T1915	T1914	nummod	million,years
R1092	T1916	T1909	advmod	ago,occurred
R1093	T1917	T1918	punct	(,MYA
R1094	T1918	T1916	parataxis	MYA,ago
R1095	T1919	T1918	punct	),MYA
R1096	T1920	T1909	punct	", ",occurred
R1097	T1921	T1909	prep	with,occurred
R1098	T1922	T1923	det	the,duplication
R1099	T1923	T1921	pobj	duplication,with
R1100	T1924	T1923	amod	first,duplication
R1101	T1925	T1923	prep	of,duplication
R1102	T1926	T1927	det	the,genome
R1103	T1927	T1925	pobj	genome,of
R1104	T1928	T1927	compound	chordate,genome
R1105	T1929	T1923	punct	", ",duplication
R1106	T1930	T1923	cc	and,duplication
R1107	T1931	T1932	det	a,duplication
R1108	T1932	T1923	conj	duplication,duplication
R1109	T1933	T1932	amod	second,duplication
R1110	T1934	T1932	acl	occurring,duplication
R1111	T1935	T1936	advmod	shortly,thereafter
R1112	T1936	T1934	advmod	thereafter,occurring
R1113	T1937	T1898	punct	.,suggested
R1114	T1939	T1940	advmod	Thus,expect
R1115	T1941	T1940	punct	", ",expect
R1116	T1942	T1943	mark	if,duplicated
R1117	T1943	T1940	advcl	duplicated,expect
R1118	T1944	T1945	det	the,genes
R1119	T1945	T1943	nsubjpass	genes,duplicated
R1120	T1946	T1945	compound	TACC,genes
R1121	T1947	T1943	auxpass	were,duplicated
R1122	T1948	T1943	prep	at,duplicated
R1123	T1949	T1950	det	both,events
R1124	T1950	T1948	pobj	events,at
R1125	T1951	T1940	punct	", ",expect
R1126	T1952	T1940	nsubj	we,expect
R1127	T1953	T1940	aux	would,expect
R1128	T1954	T1955	aux	to,identify
R1129	T1955	T1940	xcomp	identify,expect
R1130	T1956	T1957	nummod	four,genes
R1131	T1957	T1955	dobj	genes,identify
R1132	T1958	T1957	compound	TACC,genes
R1133	T1959	T1955	prep	in,identify
R1134	T1960	T1961	det	the,genome
R1135	T1961	T1959	pobj	genome,in
R1136	T1962	T1963	amod	most,primitive
R1137	T1963	T1961	amod	primitive,genome
R1138	T1964	T1963	punct	"""",primitive
R1139	T1965	T1963	punct	"""",primitive
R1140	T1966	T1961	amod	compact,genome
R1141	T1967	T1961	compound	vertebrate,genome
R1142	T1968	T1961	acl	sequenced,genome
R1143	T1969	T1961	prep	to,genome
R1144	T1970	T1969	pobj	date,to
R1145	T1971	T1961	punct	", ",genome
R1146	T1972	T1973	det	the,pufferfish
R1147	T1973	T1961	appos	pufferfish,genome
R1148	T1974	T1975	compound	Takifugu,rubripes
R1149	T1975	T1973	appos	rubripes,pufferfish
R1150	T1976	T1973	punct	", ",pufferfish
R1151	T1977	T1973	prep	with,pufferfish
R1152	T1978	T1979	nummod	three,genes
R1153	T1979	T1977	pobj	genes,with
R1154	T1980	T1979	acl	corresponding,genes
R1155	T1981	T1980	prep	to,corresponding
R1156	T1982	T1983	det	the,TACC1
R1157	T1983	T1981	pobj	TACC1,to
R1158	T1984	T1983	amod	human,TACC1
R1159	T1985	T1983	punct	-,TACC1
R1160	T1986	T1983	nummod	3,TACC1
R1161	T1987	T1979	punct	", ",genes
R1162	T1988	T1979	cc	and,genes
R1163	T1989	T1979	punct	", ",genes
R1164	T1990	T1991	prep	in,gene
R1165	T1991	T1979	conj	gene,genes
R1166	T1992	T1990	pobj	keeping,in
R1167	T1993	T1992	prep	with,keeping
R1168	T1994	T1995	det	the,model
R1169	T1995	T1993	pobj	model,with
R1170	T1996	T1995	amod	proposed,model
R1171	T1997	T1995	prep	for,model
R1172	T1998	T1999	amod	genomic,duplication
R1173	T1999	T1997	pobj	duplication,for
R1174	T2000	T1999	prep	of,duplication
R1175	T2001	T2002	det	the,loci
R1176	T2002	T2000	pobj	loci,of
R1177	T2003	T2002	amod	chromosomal,loci
R1178	T2004	T1995	prep	for,model
R1179	T2005	T2006	det	the,genes
R1180	T2006	T2004	pobj	genes,for
R1181	T2007	T2006	compound	TACC,genes
R1182	T2008	T2009	punct	(,discussed
R1183	T2009	T1995	parataxis	discussed,model
R1184	T2010	T2009	advmod	below,discussed
R1185	T2011	T2009	punct	),discussed
R1186	T2012	T1991	punct	", ",gene
R1187	T2013	T1991	det	a,gene
R1188	T2014	T1991	amod	possible,gene
R1189	T2015	T1991	amod	fourth,gene
R1190	T2016	T1991	acl	deriving,gene
R1191	T2017	T2016	prep	from,deriving
R1192	T2018	T2019	det	the,ancestor
R1193	T2019	T2017	pobj	ancestor,from
R1194	T2020	T2019	compound	TACC3,ancestor
R1195	T2021	T1940	punct	.,expect
R1196	T2023	T2024	advmod	Indeed,identified
R1197	T2025	T2024	punct	", ",identified
R1198	T2026	T2027	nummod	four,genes
R1199	T2027	T2024	nsubjpass	genes,identified
R1200	T2028	T2027	compound	TACC,genes
R1201	T2029	T2024	auxpass	were,identified
R1202	T2030	T2024	prep	in,identified
R1203	T2031	T2032	compound	T.,rubripes
R1204	T2032	T2030	pobj	rubripes,in
R1205	T2033	T2024	punct	.,identified
R1206	T2035	T2036	prep	Of,corresponded
R1207	T2037	T2035	pobj	these,Of
R1208	T2038	T2036	punct	", ",corresponded
R1209	T2039	T2040	nummod	two,genes
R1210	T2040	T2036	nsubj	genes,corresponded
R1211	T2041	T2036	prep	to,corresponded
R1212	T2042	T2043	det	the,orthologues
R1213	T2043	T2041	pobj	orthologues,to
R1214	T2044	T2045	compound	T.,rubripes
R1215	T2045	T2043	compound	rubripes,orthologues
R1216	T2046	T2043	prep	of,orthologues
R1217	T2047	T2048	amod	human,TACC2
R1218	T2048	T2046	pobj	TACC2,of
R1219	T2049	T2048	cc	and,TACC2
R1220	T2050	T2048	conj	TACC3,TACC2
R1221	T2051	T2036	punct	.,corresponded
R1222	T2053	T2054	advmod	However,are
R1223	T2055	T2054	punct	", ",are
R1224	T2056	T2057	det	the,genes
R1225	T2057	T2054	nsubj	genes,are
R1226	T2058	T2057	amod	other,genes
R1227	T2059	T2057	nummod	two,genes
R1228	T2060	T2057	punct	", ",genes
R1229	T2061	T2057	appos	trTACC1A,genes
R1230	T2062	T2061	cc	and,trTACC1A
R1231	T2063	T2061	conj	trTACC1B,trTACC1A
R1232	T2064	T2054	advmod	clearly,are
R1233	T2065	T2066	advmod	most,related
R1234	T2066	T2054	acomp	related,are
R1235	T2067	T2066	prep	to,related
R1236	T2068	T2067	pobj	TACC1,to
R1237	T2069	T2070	punct	(,Fig.
R1238	T2070	T2054	parataxis	Fig.,are
R1239	T2071	T2070	nummod	1,Fig.
R1240	T2072	T2070	punct	),Fig.
R1241	T2073	T2054	punct	.,are
R1242	T2075	T2076	mark	Although,is
R1243	T2076	T2078	advcl	is,encodes
R1244	T2077	T2076	nsubj	trTACC1A,is
R1245	T2079	T2080	advmod	highly,homologous
R1246	T2080	T2076	acomp	homologous,is
R1247	T2081	T2080	prep	to,homologous
R1248	T2082	T2081	pobj	trTACC1B,to
R1249	T2083	T2078	punct	", ",encodes
R1250	T2084	T2085	det	the,latter
R1251	T2085	T2078	nsubj	latter,encodes
R1252	T2086	T2087	det	a,protein
R1253	T2087	T2078	dobj	protein,encodes
R1254	T2088	T2089	advmod	significantly,smaller
R1255	T2089	T2087	amod	smaller,protein
R1256	T2090	T2087	amod	predicted,protein
R1257	T2091	T2078	punct	.,encodes
R1258	T2093	T2094	det	The,gene
R1259	T2094	T2096	nsubjpass	gene,encoded
R1260	T2095	T2094	compound	trTACC1B,gene
R1261	T2097	T2096	auxpass	is,encoded
R1262	T2098	T2096	agent	by,encoded
R1263	T2099	T2100	nummod	15,exons
R1264	T2100	T2098	pobj	exons,by
R1265	T2101	T2096	prep	over,encoded
R1266	T2102	T2103	advmod	approximately,7
R1267	T2103	T2104	nummod	7,kb
R1268	T2104	T2101	pobj	kb,over
R1269	T2105	T2104	prep	of,kb
R1270	T2106	T2107	det	the,Scaffold
R1271	T2107	T2105	pobj	Scaffold,of
R1272	T2108	T2107	compound	Takifugu,Scaffold
R1273	T2109	T2107	nummod	191,Scaffold
R1274	T2110	T2111	punct	(,see
R1275	T2111	T2096	parataxis	see,encoded
R1276	T2112	T2111	advmod	below,see
R1277	T2113	T2111	punct	),see
R1278	T2114	T2096	punct	.,encoded
R1279	T2116	T2117	det	A,search
R1280	T2117	T2118	nsubj	search,failed
R1281	T2119	T2117	prep	of,search
R1282	T2120	T2121	det	this,region
R1283	T2121	T2119	pobj	region,of
R1284	T2122	T2117	acl	using,search
R1285	T2123	T2124	det	the,software
R1286	T2124	T2122	dobj	software,using
R1287	T2125	T2126	nmod	trTACC1A,sequence
R1288	T2126	T2124	nmod	sequence,software
R1289	T2127	T2126	cc	and,sequence
R1290	T2128	T2129	compound	gene,prediction
R1291	T2129	T2126	conj	prediction,sequence
R1292	T2130	T2118	aux	has,failed
R1293	T2131	T2132	advmod	so,far
R1294	T2132	T2118	advmod	far,failed
R1295	T2133	T2134	aux	to,identify
R1296	T2134	T2118	xcomp	identify,failed
R1297	T2135	T2136	amod	additional,exons
R1298	T2136	T2134	dobj	exons,identify
R1299	T2137	T2136	prep	of,exons
R1300	T2138	T2137	pobj	trTACC1B,of
R1301	T2139	T2118	punct	.,failed
R1302	T2141	T2142	advmod	However,appears
R1303	T2143	T2142	punct	", ",appears
R1304	T2144	T2142	prep	given,appears
R1305	T2145	T2146	det	the,structure
R1306	T2146	T2144	pobj	structure,given
R1307	T2147	T2148	compound	intron,exon
R1308	T2148	T2146	compound	exon,structure
R1309	T2149	T2148	punct	/,exon
R1310	T2150	T2146	prep	of,structure
R1311	T2151	T2152	det	this,gene
R1312	T2152	T2150	pobj	gene,of
R1313	T2153	T2154	advmod	apparently,complete
R1314	T2154	T2152	amod	complete,gene
R1315	T2155	T2142	punct	", ",appears
R1316	T2156	T2142	nsubj	it,appears
R1317	T2157	T2142	oprd	likely,appears
R1318	T2158	T2159	mark	that,is
R1319	T2159	T2142	ccomp	is,appears
R1320	T2160	T2159	nsubj	trTACC1B,is
R1321	T2161	T2159	acomp	active,is
R1322	T2162	T2159	prep	in,is
R1323	T2163	T2164	det	the,pufferfish
R1324	T2164	T2162	pobj	pufferfish,in
R1325	T2165	T2159	punct	", ",is
R1326	T2166	T2159	cc	and,is
R1327	T2167	T2168	advmod	presumably,fulfils
R1328	T2168	T2159	conj	fulfils,is
R1329	T2169	T2170	preconj	either,function
R1330	T2170	T2168	dobj	function,fulfils
R1331	T2171	T2170	det	a,function
R1332	T2172	T2173	amod	temporal,spatial
R1333	T2173	T2170	amod	spatial,function
R1334	T2174	T2173	punct	-,spatial
R1335	T2175	T2170	amod	specific,function
R1336	T2176	T2170	prep	within,function
R1337	T2177	T2178	det	the,organism
R1338	T2178	T2176	pobj	organism,within
R1339	T2179	T2170	punct	", ",function
R1340	T2180	T2170	cc	or,function
R1341	T2181	T2182	det	a,function
R1342	T2182	T2170	conj	function,function
R1343	T2183	T2182	amod	distinct,function
R1344	T2184	T2182	prep	from,function
R1345	T2185	T2186	det	the,product
R1346	T2186	T2184	pobj	product,from
R1347	T2187	T2186	amod	larger,product
R1348	T2188	T2186	compound	trTACC1A,product
R1349	T2189	T2182	prep	within,function
R1350	T2190	T2191	det	the,cell
R1351	T2191	T2189	pobj	cell,within
R1352	T2192	T2142	punct	.,appears
R1353	T2194	T2195	advmod	Thus,appear
R1354	T2196	T2195	punct	", ",appear
R1355	T2197	T2195	prep	based,appear
R1356	T2198	T2197	prep	upon,based
R1357	T2199	T2200	det	the,loci
R1358	T2200	T2198	pobj	loci,upon
R1359	T2201	T2200	amod	surrounding,loci
R1360	T2202	T2200	amod	chromosomal,loci
R1361	T2203	T2204	punct	(,see
R1362	T2204	T2200	parataxis	see,loci
R1363	T2205	T2204	advmod	below,see
R1364	T2206	T2204	punct	),see
R1365	T2207	T2195	punct	", ",appear
R1366	T2208	T2209	det	the,genes
R1367	T2209	T2195	nsubj	genes,appear
R1368	T2210	T2209	nmod	trTACC1A,genes
R1369	T2211	T2210	cc	and,trTACC1A
R1370	T2212	T2210	conj	trTACC1B,trTACC1A
R1371	T2213	T2214	aux	to,arisen
R1372	T2214	T2195	xcomp	arisen,appear
R1373	T2215	T2214	aux	have,arisen
R1374	T2216	T2214	prep	from,arisen
R1375	T2217	T2218	det	the,duplication
R1376	T2218	T2216	pobj	duplication,from
R1377	T2219	T2218	prep	of,duplication
R1378	T2220	T2221	det	the,segment
R1379	T2221	T2219	pobj	segment,of
R1380	T2222	T2221	amod	chromosomal,segment
R1381	T2223	T2221	acl	containing,segment
R1382	T2224	T2225	det	the,ancestor
R1383	T2225	T2223	dobj	ancestor,containing
R1384	T2226	T2225	compound	teleost,ancestor
R1385	T2227	T2225	compound	TACC1,ancestor
R1386	T2228	T2218	punct	", ",duplication
R1387	T2229	T2218	prep	during,duplication
R1388	T2230	T2231	det	the,duplication
R1389	T2231	T2229	pobj	duplication,during
R1390	T2232	T2231	amod	additional,duplication
R1391	T2233	T2231	amod	partial,duplication
R1392	T2234	T2231	amod	genomic,duplication
R1393	T2235	T2236	dep	that,occurred
R1394	T2236	T2231	relcl	occurred,duplication
R1395	T2237	T2236	prep	in,occurred
R1396	T2238	T2239	det	the,lineage
R1397	T2239	T2237	pobj	lineage,in
R1398	T2240	T2239	compound	teleost,lineage
R1399	T2241	T2195	punct	.,appear
R1400	T2243	T2244	advmod	Therefore,support
R1401	T2245	T2244	punct	", ",support
R1402	T2246	T2247	det	this,analysis
R1403	T2247	T2244	nsubj	analysis,support
R1404	T2248	T2247	prep	of,analysis
R1405	T2249	T2250	compound	T.,rubripes
R1406	T2250	T2248	pobj	rubripes,of
R1407	T2251	T2244	aux	does,support
R1408	T2252	T2244	neg	not,support
R1409	T2253	T2254	det	the,hypothesis
R1410	T2254	T2244	dobj	hypothesis,support
R1411	T2255	T2256	mark	that,included
R1412	T2256	T2254	acl	included,hypothesis
R1413	T2257	T2258	det	the,region
R1414	T2258	T2256	nsubjpass	region,included
R1415	T2259	T2258	acl	surrounding,region
R1416	T2260	T2261	det	the,ancestor
R1417	T2261	T2259	dobj	ancestor,surrounding
R1418	T2262	T2261	compound	TACC3,ancestor
R1419	T2263	T2256	auxpass	was,included
R1420	T2264	T2256	prep	in,included
R1421	T2265	T2266	det	the,round
R1422	T2266	T2264	pobj	round,in
R1423	T2267	T2266	amod	second,round
R1424	T2268	T2266	prep	of,round
R1425	T2269	T2270	nmod	vertebrate,duplication
R1426	T2270	T2268	pobj	duplication,of
R1427	T2271	T2270	amod	genomic,duplication
R1428	T2272	T2244	punct	.,support
R1429	T2274	T2275	nsubj	Examination,led
R1430	T2276	T2274	prep	of,Examination
R1431	T2277	T2278	amod	higher,vertebrates
R1432	T2278	T2276	pobj	vertebrates,of
R1433	T2279	T2275	prep	to,led
R1434	T2280	T2281	det	the,identification
R1435	T2281	T2279	pobj	identification,to
R1436	T2282	T2281	prep	of,identification
R1437	T2283	T2284	compound	splice,variants
R1438	T2284	T2282	pobj	variants,of
R1439	T2285	T2284	prep	of,variants
R1440	T2286	T2285	pobj	TACC1,of
R1441	T2287	T2286	cc	and,TACC1
R1442	T2288	T2286	conj	TACC2,TACC1
R1443	T2289	T2281	prep	in,identification
R1444	T2290	T2291	compound	Mus,musculus
R1445	T2291	T2289	pobj	musculus,in
R1446	T2292	T2281	punct	", ",identification
R1447	T2293	T2281	cc	and,identification
R1448	T2294	T2295	det	the,assembly
R1449	T2295	T2281	conj	assembly,identification
R1450	T2296	T2295	prep	of,assembly
R1451	T2297	T2298	det	the,orthologues
R1452	T2298	T2296	pobj	orthologues,of
R1453	T2299	T2300	advmod	previously,unidentified
R1454	T2300	T2298	amod	unidentified,orthologues
R1455	T2301	T2298	prep	of,orthologues
R1456	T2302	T2301	pobj	TACC1,of
R1457	T2303	T2302	punct	-,TACC1
R1458	T2304	T2302	nummod	3,TACC1
R1459	T2305	T2295	prep	from,assembly
R1460	T2306	T2307	compound	Rattus,norvegus
R1461	T2307	T2305	pobj	norvegus,from
R1462	T2308	T2275	punct	.,led
R1463	T2310	T2311	prep	In,found
R1464	T2312	T2310	pobj	addition,In
R1465	T2313	T2311	punct	", ",found
R1466	T2314	T2315	det	the,sequence
R1467	T2315	T2311	nsubjpass	sequence,found
R1468	T2316	T2315	compound	TACC1X,sequence
R1469	T2317	T2311	auxpass	was,found
R1470	T2318	T2311	prep	on,found
R1471	T2319	T2320	compound	mouse,X
R1472	T2320	T2318	pobj	X,on
R1473	T2321	T2320	compound	chromosome,X
R1474	T2322	T2311	punct	.,found
R1475	T2324	T2325	det	This,gene
R1476	T2325	T2326	nsubjpass	gene,related
R1477	T2326	T2329	ccomp	related,revealed
R1478	T2327	T2326	auxpass	is,related
R1479	T2328	T2326	advmod	clearly,related
R1480	T2330	T2326	prep	to,related
R1481	T2331	T2332	det	the,TACC1
R1482	T2332	T2330	pobj	TACC1,to
R1483	T2333	T2332	compound	mouse,TACC1
R1484	T2334	T2329	punct	", ",revealed
R1485	T2335	T2329	advmod	however,revealed
R1486	T2336	T2329	punct	", ",revealed
R1487	T2337	T2338	amod	further,examination
R1488	T2338	T2329	nsubj	examination,revealed
R1489	T2339	T2340	det	a,repeat
R1490	T2340	T2329	dobj	repeat,revealed
R1491	T2341	T2340	compound	mouse,repeat
R1492	T2342	T2340	compound	B1,repeat
R1493	T2343	T2340	acl	distributed,repeat
R1494	T2344	T2343	prep	over,distributed
R1495	T2345	T2346	det	the,length
R1496	T2346	T2344	pobj	length,over
R1497	T2347	T2346	prep	of,length
R1498	T2348	T2349	det	the,intron
R1499	T2349	T2347	pobj	intron,of
R1500	T2350	T2349	amod	proposed,intron
R1501	T2351	T2329	punct	.,revealed
R1502	T2353	T2354	prep	In,detected
R1503	T2355	T2353	pobj	addition,In
R1504	T2356	T2354	punct	", ",detected
R1505	T2357	T2358	det	no,expression
R1506	T2358	T2354	nsubjpass	expression,detected
R1507	T2359	T2358	prep	of,expression
R1508	T2360	T2359	pobj	TACC1X,of
R1509	T2361	T2354	auxpass	was,detected
R1510	T2362	T2354	prep	in,detected
R1511	T2363	T2364	compound	mouse,RNA
R1512	T2364	T2362	pobj	RNA,in
R1513	T2365	T2354	prep	by,detected
R1514	T2366	T2367	compound	rt,PCR
R1515	T2367	T2369	compound	PCR,analysis
R1516	T2368	T2367	punct	-,PCR
R1517	T2369	T2365	pobj	analysis,by
R1518	T2370	T2371	punct	(,shown
R1519	T2371	T2354	parataxis	shown,detected
R1520	T2372	T2371	nsubj	data,shown
R1521	T2373	T2371	neg	not,shown
R1522	T2374	T2371	punct	),shown
R1523	T2375	T2354	punct	", ",detected
R1524	T2376	T2354	advcl	suggesting,detected
R1525	T2377	T2378	mark	that,is
R1526	T2378	T2376	ccomp	is,suggesting
R1527	T2379	T2380	det	this,sequence
R1528	T2380	T2378	nsubj	sequence,is
R1529	T2381	T2382	det	a,pseudogene
R1530	T2382	T2378	attr	pseudogene,is
R1531	T2383	T2382	amod	processed,pseudogene
R1532	T2384	T2354	punct	.,detected
R1533	T2386	T2387	advmod	Similarly,exist
R1534	T2388	T2387	punct	", ",exist
R1535	T2389	T2390	compound	TACC1,pseudogenes
R1536	T2390	T2387	nsubj	pseudogenes,exist
R1537	T2391	T2387	advmod	also,exist
R1538	T2392	T2387	advcl	spread,exist
R1539	T2393	T2392	prep	over,spread
R1540	T2394	T2395	nummod	22,kb
R1541	T2395	T2393	pobj	kb,over
R1542	T2396	T2395	prep	of,kb
R1543	T2397	T2398	det	the,region
R1544	T2398	T2396	pobj	region,of
R1545	T2399	T2398	amod	centromeric,region
R1546	T2400	T2398	prep	of,region
R1547	T2401	T2402	amod	human,chromosome
R1548	T2402	T2400	pobj	chromosome,of
R1549	T2403	T2402	nummod	10,chromosome
R1550	T2404	T2393	cc	and,over
R1551	T2405	T2393	punct	", ",over
R1552	T2406	T2393	conj	in,over
R1553	T2407	T2406	pobj	8q21,in
R1554	T2408	T2407	punct	", ",8q21
R1555	T2409	T2410	det	a,region
R1556	T2410	T2407	appos	region,8q21
R1557	T2411	T2410	amod	shorter,region
R1558	T2412	T2413	nummod	86,%
R1559	T2413	T2414	npadvmod	%,identical
R1560	T2414	T2410	amod	identical,region
R1561	T2415	T2414	prep	to,identical
R1562	T2416	T2417	det	the,bp
R1563	T2417	T2415	pobj	bp,to
R1564	T2418	T2417	amod	final,bp
R1565	T2419	T2417	nummod	359,bp
R1566	T2420	T2417	prep	of,bp
R1567	T2421	T2422	det	the,region
R1568	T2422	T2420	pobj	region,of
R1569	T2423	T2422	nmod	TACC1,region
R1570	T2424	T2422	nummod	3,region
R1571	T2425	T2424	punct	',3
R1572	T2426	T2422	amod	untranslated,region
R1573	T2427	T2387	punct	.,exist
R1574	T2429	T2430	det	No,pseudogenes
R1575	T2430	T2431	nsubjpass	pseudogenes,identified
R1576	T2432	T2430	acl	corresponding,pseudogenes
R1577	T2433	T2432	prep	to,corresponding
R1578	T2434	T2433	pobj	TACC2,to
R1579	T2435	T2434	cc	or,TACC2
R1580	T2436	T2434	conj	TACC3,TACC2
R1581	T2437	T2431	auxpass	were,identified
R1582	T2438	T2431	prep	in,identified
R1583	T2439	T2440	det	any,species
R1584	T2440	T2438	pobj	species,in
R1585	T2441	T2440	amod	mammalian,species
R1586	T2442	T2431	punct	.,identified
R1587	T2678	T2677	prep	of,Characterization
R1588	T2679	T2680	compound	vertebrate,TACC3
R1589	T2680	T2681	compound	TACC3,orthologues
R1590	T2681	T2678	pobj	orthologues,of
R1591	T2683	T2684	prep	Based,is
R1592	T2685	T2683	prep	upon,Based
R1593	T2686	T2687	amod	current,analysis
R1594	T2687	T2685	pobj	analysis,upon
R1595	T2688	T2687	amod	functional,analysis
R1596	T2689	T2684	punct	", ",is
R1597	T2690	T2691	det	the,characterization
R1598	T2691	T2684	nsubj	characterization,is
R1599	T2692	T2691	prep	of,characterization
R1600	T2693	T2694	compound	TACC3,orthologues
R1601	T2694	T2692	pobj	orthologues,of
R1602	T2695	T2684	acomp	likely,is
R1603	T2696	T2697	aux	to,be
R1604	T2697	T2695	xcomp	be,likely
R1605	T2698	T2697	acomp	pivotal,be
R1606	T2699	T2698	prep	to,pivotal
R1607	T2700	T2699	pcomp	understanding,to
R1608	T2701	T2702	det	the,sequence
R1609	T2702	T2700	dobj	sequence,understanding
R1610	T2703	T2702	cc	and,sequence
R1611	T2704	T2705	amod	functional,evolution
R1612	T2705	T2702	conj	evolution,sequence
R1613	T2706	T2702	prep	of,sequence
R1614	T2707	T2708	det	the,family
R1615	T2708	T2706	pobj	family,of
R1616	T2709	T2708	compound	TACC,family
R1617	T2710	T2708	compound	gene,family
R1618	T2711	T2684	punct	.,is
R1619	T2713	T2714	mark	As,indicated
R1620	T2714	T2715	advcl	indicated,duplicated
R1621	T2716	T2714	advmod	below,indicated
R1622	T2717	T2715	punct	", ",duplicated
R1623	T2718	T2719	det	the,region
R1624	T2719	T2715	nsubjpass	region,duplicated
R1625	T2720	T2719	amod	chromosomal,region
R1626	T2721	T2719	acl	containing,region
R1627	T2722	T2723	det	the,precursors
R1628	T2723	T2721	dobj	precursors,containing
R1629	T2724	T2725	compound	TACC,gene
R1630	T2725	T2723	compound	gene,precursors
R1631	T2726	T2715	auxpass	was,duplicated
R1632	T2727	T2715	advmod	twice,duplicated
R1633	T2728	T2715	prep	during,duplicated
R1634	T2729	T2730	compound	vertebrate,evolution
R1635	T2730	T2728	pobj	evolution,during
R1636	T2731	T2715	punct	.,duplicated
R1637	T2733	T2734	mark	Although,suggests
R1638	T2734	T2746	advcl	suggests,excluded
R1639	T2735	T2736	det	the,analysis
R1640	T2736	T2734	nsubj	analysis,suggests
R1641	T2737	T2736	prep	of,analysis
R1642	T2738	T2739	compound	T.,rubripes
R1643	T2739	T2737	pobj	rubripes,of
R1644	T2740	T2739	punct	", ",rubripes
R1645	T2741	T2739	conj	rodents,rubripes
R1646	T2742	T2741	cc	and,rodents
R1647	T2743	T2741	conj	humans,rodents
R1648	T2744	T2745	advmod	so,far
R1649	T2745	T2734	advmod	far,suggests
R1650	T2747	T2748	mark	that,included
R1651	T2748	T2734	ccomp	included,suggests
R1652	T2749	T2750	det	the,precursor
R1653	T2750	T2748	nsubjpass	precursor,included
R1654	T2751	T2750	compound	vertebrate,precursor
R1655	T2752	T2750	compound	TACC3,precursor
R1656	T2753	T2748	auxpass	was,included
R1657	T2754	T2748	neg	not,included
R1658	T2755	T2748	prep	in,included
R1659	T2756	T2757	det	the,round
R1660	T2757	T2755	pobj	round,in
R1661	T2758	T2757	amod	second,round
R1662	T2759	T2757	prep	of,round
R1663	T2760	T2761	amod	genomic,duplication
R1664	T2761	T2759	pobj	duplication,of
R1665	T2762	T2746	punct	", ",excluded
R1666	T2763	T2746	nsubjpass	it,excluded
R1667	T2764	T2746	aux	could,excluded
R1668	T2765	T2746	neg	not,excluded
R1669	T2766	T2746	auxpass	be,excluded
R1670	T2767	T2768	mark	that,lost
R1671	T2768	T2746	ccomp	lost,excluded
R1672	T2769	T2770	det	a,gene
R1673	T2770	T2768	nsubjpass	gene,lost
R1674	T2771	T2770	compound	TACC4,gene
R1675	T2772	T2768	aux	may,lost
R1676	T2773	T2768	aux	have,lost
R1677	T2774	T2768	auxpass	been,lost
R1678	T2775	T2768	prep	during,lost
R1679	T2776	T2777	det	the,evolution
R1680	T2777	T2775	pobj	evolution,during
R1681	T2778	T2777	prep	of,evolution
R1682	T2779	T2780	det	these,lineages
R1683	T2780	T2778	pobj	lineages,of
R1684	T2781	T2746	punct	.,excluded
R1685	T2783	T2784	det	The,cloning
R1686	T2784	T2785	nsubj	cloning,added
R1687	T2786	T2784	prep	of,cloning
R1688	T2787	T2788	det	a,member
R1689	T2788	T2786	pobj	member,of
R1690	T2789	T2788	amod	new,member
R1691	T2790	T2788	prep	of,member
R1692	T2791	T2792	det	the,family
R1693	T2792	T2790	pobj	family,of
R1694	T2793	T2792	compound	TACC,family
R1695	T2794	T2784	prep	in,cloning
R1696	T2795	T2796	compound	Oryctolagus,cuniculus
R1697	T2796	T2794	pobj	cuniculus,in
R1698	T2797	T2785	aux	has,added
R1699	T2798	T2785	prep	to,added
R1700	T2799	T2800	det	this,controversy
R1701	T2800	T2798	pobj	controversy,to
R1702	T2801	T2802	punct	[,9
R1703	T2802	T2785	parataxis	9,added
R1704	T2803	T2802	punct	],9
R1705	T2804	T2785	punct	.,added
R1706	T2806	T2807	advcl	Designated,was
R1707	T2808	T2806	oprd	TACC4,Designated
R1708	T2809	T2807	punct	", ",was
R1709	T2810	T2811	det	the,cDNA
R1710	T2811	T2807	nsubj	cDNA,was
R1711	T2812	T2813	nummod	1.5,kb
R1712	T2813	T2811	compound	kb,cDNA
R1713	T2814	T2815	advmod	highly,related
R1714	T2815	T2807	acomp	related,was
R1715	T2816	T2815	punct	", ",related
R1716	T2817	T2815	cc	but,related
R1717	T2818	T2815	conj	proposed,related
R1718	T2819	T2820	aux	to,be
R1719	T2820	T2818	xcomp	be,proposed
R1720	T2821	T2820	acomp	distinct,be
R1721	T2822	T2821	prep	from,distinct
R1722	T2823	T2822	pobj	TACC3,from
R1723	T2824	T2807	punct	.,was
R1724	T2826	T2827	advmod	However,suggested
R1725	T2828	T2827	punct	", ",suggested
R1726	T2829	T2830	compound	Northern,blot
R1727	T2830	T2831	compound	blot,data
R1728	T2831	T2827	nsubj	data,suggested
R1729	T2832	T2833	mark	that,produces
R1730	T2833	T2827	ccomp	produces,suggested
R1731	T2834	T2835	det	this,gene
R1732	T2835	T2833	nsubj	gene,produces
R1733	T2836	T2837	det	a,transcript
R1734	T2837	T2833	dobj	transcript,produces
R1735	T2838	T2837	amod	single,transcript
R1736	T2839	T2840	nummod	2.3,kb
R1737	T2840	T2837	compound	kb,transcript
R1738	T2841	T2842	punct	[,9
R1739	T2842	T2833	parataxis	9,produces
R1740	T2843	T2842	punct	],9
R1741	T2844	T2833	punct	", ",produces
R1742	T2845	T2833	advcl	indicating,produces
R1743	T2846	T2847	mark	that,was
R1744	T2847	T2845	ccomp	was,indicating
R1745	T2848	T2849	det	the,cDNA
R1746	T2849	T2847	nsubj	cDNA,was
R1747	T2850	T2849	amod	cloned,cDNA
R1748	T2851	T2847	acomp	incomplete,was
R1749	T2852	T2827	punct	.,suggested
R1750	T2854	T2855	det	The,degree
R1751	T2855	T2856	nsubj	degree,suggested
R1752	T2857	T2855	prep	of,degree
R1753	T2858	T2857	pobj	similarity,of
R1754	T2859	T2858	prep	to,similarity
R1755	T2860	T2861	det	the,sequence
R1756	T2861	T2859	pobj	sequence,to
R1757	T2862	T2861	amod	published,sequence
R1758	T2863	T2861	prep	of,sequence
R1759	T2864	T2865	amod	human,TACC3
R1760	T2865	T2863	pobj	TACC3,of
R1761	T2866	T2864	cc	and,human
R1762	T2867	T2864	conj	mouse,human
R1763	T2868	T2856	prep	to,suggested
R1764	T2869	T2868	pobj	us,to
R1765	T2870	T2871	mark	that,represents
R1766	T2871	T2856	ccomp	represents,suggested
R1767	T2872	T2871	nsubj	TACC4,represents
R1768	T2873	T2871	advmod	actually,represents
R1769	T2874	T2875	det	a,cDNA
R1770	T2875	T2871	dobj	cDNA,represents
R1771	T2876	T2875	amod	partial,cDNA
R1772	T2877	T2875	compound	rabbit,cDNA
R1773	T2878	T2875	compound	TACC3,cDNA
R1774	T2879	T2856	punct	.,suggested
R1775	T2881	T2882	aux	To,test
R1776	T2882	T2883	advcl	test,set
R1777	T2884	T2885	det	this,hypothesis
R1778	T2885	T2882	dobj	hypothesis,test
R1779	T2886	T2883	punct	", ",set
R1780	T2887	T2883	nsubj	we,set
R1781	T2888	T2883	prt	out,set
R1782	T2889	T2890	aux	to,clone
R1783	T2890	T2883	xcomp	clone,set
R1784	T2891	T2892	det	the,sequence
R1785	T2892	T2890	dobj	sequence,clone
R1786	T2893	T2892	amod	complete,sequence
R1787	T2894	T2892	compound	rabbit,sequence
R1788	T2895	T2892	compound	TACC3,sequence
R1789	T2896	T2890	punct	", ",clone
R1790	T2897	T2890	prep	based,clone
R1791	T2898	T2897	prep	upon,based
R1792	T2899	T2900	det	the,features
R1793	T2900	T2898	pobj	features,upon
R1794	T2901	T2900	amod	known,features
R1795	T2902	T2900	prep	of,features
R1796	T2903	T2904	amod	human,TACC3
R1797	T2904	T2902	pobj	TACC3,of
R1798	T2905	T2903	cc	and,human
R1799	T2906	T2903	conj	mouse,human
R1800	T2907	T2883	punct	.,set
R1801	T2909	T2910	nsubj	We,noted
R1802	T2911	T2910	aux	have,noted
R1803	T2912	T2910	advmod	previously,noted
R1804	T2913	T2914	mark	that,are
R1805	T2914	T2910	ccomp	are,noted
R1806	T2915	T2916	det	the,regions
R1807	T2916	T2914	nsubj	regions,are
R1808	T2917	T2918	npadvmod	N,terminal
R1809	T2918	T2916	amod	terminal,regions
R1810	T2919	T2918	punct	-,terminal
R1811	T2920	T2918	cc	and,terminal
R1812	T2921	T2922	npadvmod	C,terminal
R1813	T2922	T2918	conj	terminal,terminal
R1814	T2923	T2922	punct	-,terminal
R1815	T2924	T2916	prep	of,regions
R1816	T2925	T2926	det	the,proteins
R1817	T2926	T2924	pobj	proteins,of
R1818	T2927	T2926	amod	human,proteins
R1819	T2928	T2927	cc	and,human
R1820	T2929	T2927	conj	mouse,human
R1821	T2930	T2926	compound	TACC3,proteins
R1822	T2931	T2932	advmod	highly,conserved
R1823	T2932	T2914	acomp	conserved,are
R1824	T2933	T2934	punct	(,2
R1825	T2934	T2910	parataxis	2,noted
R1826	T2935	T2934	punct	[,2
R1827	T2936	T2934	punct	],2
R1828	T2937	T2934	punct	", ",2
R1829	T2938	T2934	advcl	see,2
R1830	T2939	T2938	advmod	below,see
R1831	T2940	T2934	punct	),2
R1832	T2941	T2910	punct	.,noted
R1833	T2943	T2944	advmod	Therefore,designed
R1834	T2945	T2944	punct	", ",designed
R1835	T2946	T2944	prep	based,designed
R1836	T2947	T2946	prep	upon,based
R1837	T2948	T2949	det	the,identity
R1838	T2949	T2947	pobj	identity,upon
R1839	T2950	T2949	compound	sequence,identity
R1840	T2951	T2949	prep	between,identity
R1841	T2952	T2953	det	these,genes
R1842	T2953	T2951	pobj	genes,between
R1843	T2954	T2944	punct	", ",designed
R1844	T2955	T2944	nsubj	we,designed
R1845	T2956	T2957	det	a,primer
R1846	T2957	T2944	dobj	primer,designed
R1847	T2958	T2957	compound	consensus,primer
R1848	T2959	T2957	compound	oligonucleotide,primer
R1849	T2960	T2957	punct	", ",primer
R1850	T2961	T2957	appos	T3con2,primer
R1851	T2962	T2957	punct	", ",primer
R1852	T2963	T2964	dep	that,be
R1853	T2964	T2957	relcl	be,primer
R1854	T2965	T2964	aux	would,be
R1855	T2966	T2964	acomp	suitable,be
R1856	T2967	T2966	prep	for,suitable
R1857	T2968	T2969	det	the,identification
R1858	T2969	T2967	pobj	identification,for
R1859	T2970	T2969	prep	of,identification
R1860	T2971	T2972	det	the,region
R1861	T2972	T2970	pobj	region,of
R1862	T2973	T2972	acl	containing,region
R1863	T2974	T2975	det	the,methionine
R1864	T2975	T2973	dobj	methionine,containing
R1865	T2976	T2975	compound	initiator,methionine
R1866	T2977	T2975	prep	of,methionine
R1867	T2978	T2979	det	the,cDNAs
R1868	T2979	T2977	pobj	cDNAs,of
R1869	T2980	T2979	compound	TACC3,cDNAs
R1870	T2981	T2979	prep	from,cDNAs
R1871	T2982	T2981	pobj	primates,from
R1872	T2983	T2982	cc	and,primates
R1873	T2984	T2982	conj	rodents,primates
R1874	T2985	T2944	punct	.,designed
R1875	T2987	T2988	advcl	Using,isolated
R1876	T2989	T2990	det	this,primer
R1877	T2990	T2987	dobj	primer,Using
R1878	T2991	T2987	punct	", ",Using
R1879	T2992	T2987	prep	in,Using
R1880	T2993	T2992	pobj	combination,in
R1881	T2994	T2993	prep	with,combination
R1882	T2995	T2996	det	the,primer
R1883	T2996	T2994	pobj	primer,with
R1884	T2997	T2998	npadvmod	TACC4,specific
R1885	T2998	T2996	amod	specific,primer
R1886	T2999	T2998	punct	-,specific
R1887	T3000	T2996	compound	RACE,primer
R1888	T3001	T2996	punct	(,primer
R1889	T3002	T2996	appos	RACE2,primer
R1890	T3003	T2996	punct	),primer
R1891	T3004	T2996	punct	", ",primer
R1892	T3005	T3006	advmod	initially,used
R1893	T3006	T2996	acl	used,primer
R1894	T3007	T3006	agent	by,used
R1895	T3008	T3007	pobj	Steadman,by
R1896	T3009	T3010	advmod	et,al
R1897	T3010	T3008	advmod	al,Steadman
R1898	T3011	T3012	punct	[,9
R1899	T3012	T3006	parataxis	9,used
R1900	T3013	T3012	punct	],9
R1901	T3014	T2988	punct	", ",isolated
R1902	T3015	T2988	nsubj	we,isolated
R1903	T3016	T3017	det	a,product
R1904	T3017	T2988	dobj	product,isolated
R1905	T3018	T3019	nummod	1.5,kb
R1906	T3019	T3020	compound	kb,PCR
R1907	T3020	T3017	compound	PCR,product
R1908	T3021	T2988	prep	from,isolated
R1909	T3022	T3023	compound	rabbit,cDNA
R1910	T3023	T3021	pobj	cDNA,from
R1911	T3024	T3023	compound	brain,cDNA
R1912	T3025	T2988	prep	by,isolated
R1913	T3026	T3027	compound	rt,PCR
R1914	T3027	T3025	pobj	PCR,by
R1915	T3028	T3027	punct	-,PCR
R1916	T3029	T2988	punct	.,isolated
R1917	T3031	T3032	prep	In,generated
R1918	T3033	T3031	pobj	combination,In
R1919	T3034	T3033	prep	with,combination
R1920	T3035	T3036	nummod	3,RACE
R1921	T3036	T3034	pobj	RACE,with
R1922	T3037	T3035	punct	',3
R1923	T3038	T3032	punct	", ",generated
R1924	T3039	T3032	nsubj	this,generated
R1925	T3040	T3041	det	a,cDNA
R1926	T3041	T3032	dobj	cDNA,generated
R1927	T3042	T3041	compound	consensus,cDNA
R1928	T3043	T3041	prep	of,cDNA
R1929	T3044	T3045	nummod	2283,bp
R1930	T3045	T3043	pobj	bp,of
R1931	T3046	T3047	dep	which,corresponds
R1932	T3047	T3041	relcl	corresponds,cDNA
R1933	T3048	T3047	prep	to,corresponds
R1934	T3049	T3050	det	the,size
R1935	T3050	T3048	pobj	size,to
R1936	T3051	T3050	compound	transcript,size
R1937	T3052	T3050	prep	of,size
R1938	T3053	T3054	nummod	2.3,kb
R1939	T3054	T3052	pobj	kb,of
R1940	T3055	T3050	acl	detected,size
R1941	T3056	T3055	prep	by,detected
R1942	T3057	T3058	det	the,sequence
R1943	T3058	T3056	pobj	sequence,by
R1944	T3059	T3058	punct	"""",sequence
R1945	T3060	T3058	nmod	TACC4,sequence
R1946	T3061	T3058	punct	"""",sequence
R1947	T3062	T3058	acl	reported,sequence
R1948	T3063	T3062	prep	in,reported
R1949	T3064	T3063	pobj	Figure,in
R1950	T3065	T3064	nummod	4,Figure
R1951	T3066	T3064	prep	of,Figure
R1952	T3067	T3066	pobj	Steadman,of
R1953	T3068	T3069	advmod	et,al
R1954	T3069	T3067	advmod	al,Steadman
R1955	T3070	T3071	punct	[,9
R1956	T3071	T3062	parataxis	9,reported
R1957	T3072	T3071	punct	],9
R1958	T3073	T3032	punct	.,generated
R1959	T3075	T3076	advmod	Thus,corresponds
R1960	T3077	T3076	punct	", ",corresponds
R1961	T3078	T3079	mark	while,remains
R1962	T3079	T3076	advcl	remains,corresponds
R1963	T3080	T3079	nsubj	it,remains
R1964	T3081	T3079	oprd	possible,remains
R1965	T3082	T3083	mark	that,is
R1966	T3083	T3079	ccomp	is,remains
R1967	T3084	T3085	det	the,sequence
R1968	T3085	T3083	nsubj	sequence,is
R1969	T3086	T3085	punct	"""",sequence
R1970	T3087	T3085	nmod	TACC4,sequence
R1971	T3088	T3085	punct	"""",sequence
R1972	T3089	T3090	det	an,product
R1973	T3090	T3083	attr	product,is
R1974	T3091	T3090	amod	alternative,product
R1975	T3092	T3090	compound	splice,product
R1976	T3093	T3083	punct	", ",is
R1977	T3094	T3083	cc	or,is
R1978	T3095	T3083	conj	is,is
R1979	T3096	T3097	det	the,product
R1980	T3097	T3095	attr	product,is
R1981	T3098	T3097	prep	of,product
R1982	T3099	T3098	pobj	reduplication,of
R1983	T3100	T3099	prep	of,reduplication
R1984	T3101	T3102	det	the,gene
R1985	T3102	T3100	pobj	gene,of
R1986	T3103	T3102	compound	TACC3,gene
R1987	T3104	T3105	punct	(,events
R1988	T3105	T3095	parataxis	events,is
R1989	T3106	T3107	dep	that,be
R1990	T3107	T3105	relcl	be,events
R1991	T3108	T3107	aux	would,be
R1992	T3109	T3107	acomp	specific,be
R1993	T3110	T3109	prep	to,specific
R1994	T3111	T3112	det	the,rabbit
R1995	T3112	T3110	pobj	rabbit,to
R1996	T3113	T3105	punct	),events
R1997	T3114	T3076	punct	", ",corresponds
R1998	T3115	T3116	det	the,transcript
R1999	T3116	T3076	nsubj	transcript,corresponds
R2000	T3117	T3116	amod	only,transcript
R2001	T3118	T3116	acl	detected,transcript
R2002	T3119	T3118	prep	in,detected
R2003	T3120	T3121	compound	rabbit,RNA
R2004	T3121	T3119	pobj	RNA,in
R2005	T3122	T3076	prep	to,corresponds
R2006	T3123	T3124	det	the,size
R2007	T3124	T3122	pobj	size,to
R2008	T3125	T3124	amod	predicted,size
R2009	T3126	T3124	compound	transcript,size
R2010	T3127	T3124	prep	of,size
R2011	T3128	T3129	det	the,sequence
R2012	T3129	T3127	pobj	sequence,of
R2013	T3130	T3129	compound	TACC3,sequence
R2014	T3131	T3132	dep	that,identified
R2015	T3132	T3124	relcl	identified,size
R2016	T3133	T3132	nsubj	we,identified
R2017	T3134	T3132	aux	have,identified
R2018	T3135	T3132	advmod	here,identified
R2019	T3136	T3076	punct	.,corresponds
R2020	T3138	T3139	advmod	Furthermore,found
R2021	T3140	T3139	punct	", ",found
R2022	T3141	T3142	det	the,string
R2023	T3142	T3139	nsubjpass	string,found
R2024	T3143	T3142	prep	of,string
R2025	T3144	T3143	pobj	nucleotides,of
R2026	T3145	T3144	acl	found,nucleotides
R2027	T3146	T3145	prep	at,found
R2028	T3147	T3148	det	the,end
R2029	T3148	T3146	pobj	end,at
R2030	T3149	T3148	nummod	5,end
R2031	T3150	T3149	punct	',5
R2032	T3151	T3148	prep	of,end
R2033	T3152	T3153	det	the,sequence
R2034	T3153	T3151	pobj	sequence,of
R2035	T3154	T3153	punct	"""",sequence
R2036	T3155	T3153	nmod	TACC4,sequence
R2037	T3156	T3153	punct	"""",sequence
R2038	T3157	T3139	auxpass	is,found
R2039	T3158	T3139	advmod	also,found
R2040	T3159	T3139	prep	at,found
R2041	T3160	T3161	det	the,ends
R2042	T3161	T3159	pobj	ends,at
R2043	T3162	T3161	nummod	5,ends
R2044	T3163	T3162	punct	',5
R2045	T3164	T3161	prep	of,ends
R2046	T3165	T3166	det	a,number
R2047	T3166	T3164	pobj	number,of
R2048	T3167	T3166	prep	of,number
R2049	T3168	T3169	compound	cDNA,sequences
R2050	T3169	T3167	pobj	sequences,of
R2051	T3170	T3169	punct	(,sequences
R2052	T3171	T3172	advmod	e.g.,NM_023500
R2053	T3172	T3169	appos	NM_023500,sequences
R2054	T3173	T3172	nmod	U82468,NM_023500
R2055	T3174	T3172	punct	", ",NM_023500
R2056	T3175	T3169	punct	),sequences
R2057	T3176	T3169	punct	", ",sequences
R2058	T3177	T3178	dep	that,isolated
R2059	T3178	T3169	relcl	isolated,sequences
R2060	T3179	T3178	auxpass	were,isolated
R2061	T3180	T3178	agent	by,isolated
R2062	T3181	T3182	nummod	5,RACE
R2063	T3182	T3180	pobj	RACE,by
R2064	T3183	T3181	punct	',5
R2065	T3184	T3139	punct	", ",found
R2066	T3185	T3139	advcl	suggesting,found
R2067	T3186	T3187	mark	that,correspond
R2068	T3187	T3185	ccomp	correspond,suggesting
R2069	T3188	T3187	nsubj	they,correspond
R2070	T3189	T3187	aux	may,correspond
R2071	T3190	T3187	prep	to,correspond
R2072	T3191	T3192	det	an,artefact
R2073	T3192	T3190	pobj	artefact,to
R2074	T3193	T3192	prep	of,artefact
R2075	T3194	T3195	det	the,methodology
R2076	T3195	T3193	pobj	methodology,of
R2077	T3196	T3195	nummod	5,methodology
R2078	T3197	T3196	punct	',5
R2079	T3198	T3195	compound	RACE,methodology
R2080	T3199	T3195	acl	used,methodology
R2081	T3200	T3199	prep	in,used
R2082	T3201	T3202	poss	their,construction
R2083	T3202	T3200	pobj	construction,in
R2084	T3203	T3139	punct	.,found
R2085	T3205	T3206	det	The,TACC4
R2086	T3206	T3209	nsubjpass	TACC4,found
R2087	T3207	T3206	nmod	rabbit,TACC4
R2088	T3208	T3206	punct	"""",TACC4
R2089	T3210	T3206	punct	"""",TACC4
R2090	T3211	T3206	cc	and,TACC4
R2091	T3212	T3213	det	the,TACC3
R2092	T3213	T3215	compound	TACC3,sequence
R2093	T3214	T3213	compound	rabbit,TACC3
R2094	T3215	T3206	conj	sequence,TACC4
R2095	T3216	T3217	dep	that,isolated
R2096	T3217	T3206	relcl	isolated,TACC4
R2097	T3218	T3217	nsubj	we,isolated
R2098	T3219	T3217	aux	have,isolated
R2099	T3220	T3209	auxpass	are,found
R2100	T3221	T3209	advmod	also,found
R2101	T3222	T3209	prep	on,found
R2102	T3223	T3224	det	the,branch
R2103	T3224	T3222	pobj	branch,on
R2104	T3225	T3224	amod	same,branch
R2105	T3226	T3224	prep	of,branch
R2106	T3227	T3228	det	the,tree
R2107	T3228	T3226	pobj	tree,of
R2108	T3229	T3228	nmod	TACC,tree
R2109	T3230	T3228	amod	phylogenetic,tree
R2110	T3231	T3209	prep	with,found
R2111	T3232	T3233	det	the,orthologues
R2112	T3233	T3231	pobj	orthologues,with
R2113	T3234	T3233	amod	other,orthologues
R2114	T3235	T3233	compound	TACC3,orthologues
R2115	T3236	T3233	punct	", ",orthologues
R2116	T3237	T3233	prep	including,orthologues
R2117	T3238	T3237	pobj	maskin,including
R2118	T3239	T3238	punct	(,maskin
R2119	T3240	T3241	compound	Xenopus,laevis
R2120	T3241	T3238	appos	laevis,maskin
R2121	T3242	T3238	punct	),maskin
R2122	T3243	T3238	punct	", ",maskin
R2123	T3244	T3238	cc	and,maskin
R2124	T3245	T3246	det	the,sequences
R2125	T3246	T3238	conj	sequences,maskin
R2126	T3247	T3248	advmod	newly,identified
R2127	T3248	T3246	amod	identified,sequences
R2128	T3249	T3246	compound	TACC3,sequences
R2129	T3250	T3246	prep	in,sequences
R2130	T3251	T3252	compound	Rattus,norvegus
R2131	T3252	T3250	pobj	norvegus,in
R2132	T3253	T3252	punct	", ",norvegus
R2133	T3254	T3255	compound	Gallus,gallus
R2134	T3255	T3252	conj	gallus,norvegus
R2135	T3256	T3255	punct	", ",gallus
R2136	T3257	T3258	compound	Silurana,tropicalis
R2137	T3258	T3255	conj	tropicalis,gallus
R2138	T3259	T3258	punct	", ",tropicalis
R2139	T3260	T3261	compound	Danio,rerio
R2140	T3261	T3258	conj	rerio,tropicalis
R2141	T3262	T3261	cc	and,rerio
R2142	T3263	T3264	compound	T.,rubripes
R2143	T3264	T3261	conj	rubripes,rerio
R2144	T3265	T3246	punct	", ",sequences
R2145	T3266	T3246	acl	reported,sequences
R2146	T3267	T3266	prep	in,reported
R2147	T3268	T3269	det	this,manuscript
R2148	T3269	T3267	pobj	manuscript,in
R2149	T3270	T3271	punct	(,Fig.
R2150	T3271	T3209	parataxis	Fig.,found
R2151	T3272	T3271	nummod	1,Fig.
R2152	T3273	T3271	punct	),Fig.
R2153	T3274	T3209	punct	.,found
R2154	T3276	T3277	advmod	Thus,is
R2155	T3278	T3277	punct	", ",is
R2156	T3279	T3277	nsubj	it,is
R2157	T3280	T3277	neg	not,is
R2158	T3281	T3277	prep	in,is
R2159	T3282	T3283	det	a,branch
R2160	T3283	T3281	pobj	branch,in
R2161	T3284	T3283	amod	separate,branch
R2162	T3285	T3286	dep	that,expected
R2163	T3286	T3283	relcl	expected,branch
R2164	T3287	T3286	aux	may,expected
R2165	T3288	T3286	auxpass	be,expected
R2166	T3289	T3290	mark	if,was
R2167	T3290	T3277	advcl	was,is
R2168	T3291	T3292	det	the,sequence
R2169	T3292	T3290	nsubj	sequence,was
R2170	T3293	T3294	det	a,member
R2171	T3294	T3290	attr	member,was
R2172	T3295	T3294	amod	distinct,member
R2173	T3296	T3294	compound	TACC,member
R2174	T3297	T3294	compound	family,member
R2175	T3298	T3277	punct	.,is
R2176	T3413	T3412	prep	of,Placement
R2177	T3414	T3415	det	the,gene
R2178	T3415	T3413	pobj	gene,of
R2179	T3416	T3415	compound	RHAMM,gene
R2180	T3417	T3412	prep	in,Placement
R2181	T3418	T3419	det	the,phylogeny
R2182	T3419	T3417	pobj	phylogeny,in
R2183	T3420	T3419	prep	of,phylogeny
R2184	T3421	T3422	det	the,family
R2185	T3422	T3420	pobj	family,of
R2186	T3423	T3424	amod	coiled,coil
R2187	T3424	T3422	compound	coil,family
R2188	T3425	T3422	compound	gene,family
R2189	T3427	T3428	amod	Human,RHAMM
R2190	T3428	T3429	nsubjpass	RHAMM,proposed
R2191	T3430	T3429	aux	has,proposed
R2192	T3431	T3429	advmod	also,proposed
R2193	T3432	T3429	auxpass	been,proposed
R2194	T3433	T3434	aux	to,be
R2195	T3434	T3429	xcomp	be,proposed
R2196	T3435	T3436	det	the,member
R2197	T3436	T3434	attr	member,be
R2198	T3437	T3436	amod	missing,member
R2199	T3438	T3436	amod	fourth,member
R2200	T3439	T3436	prep	of,member
R2201	T3440	T3441	det	the,family
R2202	T3441	T3439	pobj	family,of
R2203	T3442	T3441	compound	TACC,family
R2204	T3443	T3444	punct	[,10
R2205	T3444	T3429	parataxis	10,proposed
R2206	T3445	T3444	punct	],10
R2207	T3446	T3429	punct	.,proposed
R2208	T3448	T3449	nsubj	Evidence,included
R2209	T3450	T3448	acl	used,Evidence
R2210	T3451	T3450	prep	in,used
R2211	T3452	T3451	pobj	support,in
R2212	T3453	T3452	prep	of,support
R2213	T3454	T3455	det	this,claim
R2214	T3455	T3453	pobj	claim,of
R2215	T3456	T3457	poss	its,location
R2216	T3457	T3449	dobj	location,included
R2217	T3458	T3457	amod	chromosomal,location
R2218	T3459	T3457	prep	on,location
R2219	T3460	T3459	pobj	5q32,on
R2220	T3461	T3457	prep	in,location
R2221	T3462	T3461	pobj	humans,in
R2222	T3463	T3464	punct	(,discussed
R2223	T3464	T3457	parataxis	discussed,location
R2224	T3465	T3464	advmod	below,discussed
R2225	T3466	T3464	punct	),discussed
R2226	T3467	T3457	punct	", ",location
R2227	T3468	T3469	poss	its,similarity
R2228	T3469	T3457	conj	similarity,location
R2229	T3470	T3469	compound	sequence,similarity
R2230	T3471	T3469	prep	in,similarity
R2231	T3472	T3473	poss	its,domain
R2232	T3473	T3471	pobj	domain,in
R2233	T3474	T3475	amod	coiled,coil
R2234	T3475	T3473	compound	coil,domain
R2235	T3476	T3469	prep	to,similarity
R2236	T3477	T3478	det	the,domain
R2237	T3478	T3476	pobj	domain,to
R2238	T3479	T3478	compound	TACC,domain
R2239	T3480	T3469	cc	and,similarity
R2240	T3481	T3482	det	the,localization
R2241	T3482	T3469	conj	localization,similarity
R2242	T3483	T3482	amod	subcellular,localization
R2243	T3484	T3482	prep	of,localization
R2244	T3485	T3486	det	the,protein
R2245	T3486	T3484	pobj	protein,of
R2246	T3487	T3486	compound	RHAMM,protein
R2247	T3488	T3482	prep	in,localization
R2248	T3489	T3490	det	the,centrosome
R2249	T3490	T3488	pobj	centrosome,in
R2250	T3491	T3449	punct	.,included
R2251	T3493	T3494	advmod	However,predict
R2252	T3495	T3494	punct	", ",predict
R2253	T3496	T3497	mark	if,were
R2254	T3497	T3494	advcl	were,predict
R2255	T3498	T3497	nsubj	RHAMM,were
R2256	T3499	T3500	det	a,member
R2257	T3500	T3497	attr	member,were
R2258	T3501	T3502	advmod	bona,fide
R2259	T3502	T3500	amod	fide,member
R2260	T3503	T3500	compound	TACC,member
R2261	T3504	T3500	compound	family,member
R2262	T3505	T3494	punct	", ",predict
R2263	T3506	T3494	advmod	then,predict
R2264	T3507	T3494	nsubj	we,predict
R2265	T3508	T3494	aux	would,predict
R2266	T3509	T3510	poss	its,evolution
R2267	T3510	T3511	nsubj	evolution,be
R2268	T3511	T3494	advcl	be,predict
R2269	T3512	T3511	aux	would,be
R2270	T3513	T3511	acomp	similar,be
R2271	T3514	T3513	prep	to,similar
R2272	T3515	T3514	pobj	those,to
R2273	T3516	T3515	prep	of,those
R2274	T3517	T3518	amod	other,members
R2275	T3518	T3516	pobj	members,of
R2276	T3519	T3518	compound	TACC,members
R2277	T3520	T3518	compound	family,members
R2278	T3521	T3511	punct	", ",be
R2279	T3522	T3511	cc	and,be
R2280	T3523	T3511	conj	fit,be
R2281	T3524	T3523	prep	with,fit
R2282	T3525	T3526	det	the,evolution
R2283	T3526	T3524	pobj	evolution,with
R2284	T3527	T3526	amod	proposed,evolution
R2285	T3528	T3526	prep	of,evolution
R2286	T3529	T3530	det	the,genome
R2287	T3530	T3528	pobj	genome,of
R2288	T3531	T3530	compound	vertebrate,genome
R2289	T3532	T3494	punct	.,predict
R2290	T3534	T3535	advmod	Thus,set
R2291	T3536	T3535	punct	", ",set
R2292	T3537	T3535	nsubj	we,set
R2293	T3538	T3535	prt	out,set
R2294	T3539	T3540	aux	to,identify
R2295	T3540	T3535	advcl	identify,set
R2296	T3541	T3542	compound	RHAMM,orthologues
R2297	T3542	T3540	dobj	orthologues,identify
R2298	T3543	T3542	cc	and,orthologues
R2299	T3544	T3545	amod	related,genes
R2300	T3545	T3542	conj	genes,orthologues
R2301	T3546	T3540	prep	in,identify
R2302	T3547	T3546	pobj	metazoans,in
R2303	T3548	T3540	punct	", ",identify
R2304	T3549	T3550	mark	so,generated
R2305	T3550	T3540	advcl	generated,identify
R2306	T3551	T3550	mark	that,generated
R2307	T3552	T3553	det	a,phylogeny
R2308	T3553	T3550	nsubjpass	phylogeny,generated
R2309	T3554	T3555	advmod	more,complete
R2310	T3555	T3553	amod	complete,phylogeny
R2311	T3556	T3553	prep	of,phylogeny
R2312	T3557	T3558	det	the,family
R2313	T3558	T3556	pobj	family,of
R2314	T3559	T3560	amod	coiled,coil
R2315	T3560	T3558	nmod	coil,family
R2316	T3561	T3558	amod	super,family
R2317	T3562	T3550	aux	could,generated
R2318	T3563	T3550	auxpass	be,generated
R2319	T3564	T3535	punct	.,set
R2320	T3566	T3567	nsubj	We,identified
R2321	T3568	T3569	det	a,gene
R2322	T3569	T3567	dobj	gene,identified
R2323	T3570	T3569	amod	single,gene
R2324	T3571	T3569	compound	RHAMM,gene
R2325	T3572	T3567	prep	in,identified
R2326	T3573	T3574	det	all,deuterostomes
R2327	T3574	T3572	pobj	deuterostomes,in
R2328	T3575	T3576	prep	for,was
R2329	T3576	T3574	relcl	was,deuterostomes
R2330	T3577	T3575	pobj	which,for
R2331	T3578	T3579	nmod	cDNA,sequence
R2332	T3579	T3576	nsubj	sequence,was
R2333	T3580	T3578	cc	and,cDNA
R2334	T3581	T3580	punct	/,and
R2335	T3582	T3580	cc	or,and
R2336	T3583	T3578	conj	genomic,cDNA
R2337	T3584	T3576	acomp	available,was
R2338	T3585	T3576	punct	", ",was
R2339	T3586	T3576	prep	including,was
R2340	T3587	T3588	compound	C.,intestinalis
R2341	T3588	T3586	pobj	intestinalis,including
R2342	T3589	T3567	punct	.,identified
R2343	T3591	T3592	det	No,gene
R2344	T3592	T3594	nsubjpass	gene,identified
R2345	T3593	T3592	compound	RHAMM,gene
R2346	T3595	T3594	auxpass	was,identified
R2347	T3596	T3594	prep	in,identified
R2348	T3597	T3596	pobj	insects,in
R2349	T3598	T3597	cc	or,insects
R2350	T3599	T3597	conj	nematodes,insects
R2351	T3600	T3594	punct	.,identified
R2352	T3602	T3603	nsubj	This,indicates
R2353	T3604	T3605	mark	that,diverged
R2354	T3605	T3603	ccomp	diverged,indicates
R2355	T3606	T3607	det	the,genes
R2356	T3607	T3605	nsubj	genes,diverged
R2357	T3608	T3609	compound	RHAMM,TACC
R2358	T3609	T3607	compound	TACC,genes
R2359	T3610	T3609	punct	/,TACC
R2360	T3611	T3612	mark	after,split
R2361	T3612	T3605	advcl	split,diverged
R2362	T3613	T3614	det	the,deuterostome
R2363	T3614	T3612	nsubj	deuterostome,split
R2364	T3615	T3614	compound	protostome,deuterostome
R2365	T3616	T3614	punct	/,deuterostome
R2366	T3617	T3618	quantmod	833,933
R2367	T3618	T3620	npadvmod	933,MYA
R2368	T3619	T3618	punct	–,933
R2369	T3620	T3612	advmod	MYA,split
R2370	T3621	T3620	punct	", ",MYA
R2371	T3622	T3620	cc	but,MYA
R2372	T3623	T3620	conj	prior,MYA
R2373	T3624	T3623	prep	to,prior
R2374	T3625	T3626	det	the,divergence
R2375	T3626	T3624	pobj	divergence,to
R2376	T3627	T3628	compound	echinodermata,urochordate
R2377	T3628	T3626	compound	urochordate,divergence
R2378	T3629	T3628	punct	/,urochordate
R2379	T3630	T3631	punct	(,MYA
R2380	T3631	T3626	parataxis	MYA,divergence
R2381	T3632	T3633	punct	>,750
R2382	T3633	T3631	npadvmod	750,MYA
R2383	T3634	T3631	punct	),MYA
R2384	T3635	T3603	punct	.,indicates
R2385	T3637	T3638	advmod	Significantly,shows
R2386	T3639	T3638	punct	", ",shows
R2387	T3640	T3641	nmod	sequence,analysis
R2388	T3641	T3638	nsubj	analysis,shows
R2389	T3642	T3640	cc	and,sequence
R2390	T3643	T3640	conj	phylogenetic,sequence
R2391	T3644	T3641	prep	of,analysis
R2392	T3645	T3646	amod	coiled,coil
R2393	T3646	T3647	compound	coil,proteins
R2394	T3647	T3644	pobj	proteins,of
R2395	T3648	T3649	punct	(,Fig.
R2396	T3649	T3641	parataxis	Fig.,analysis
R2397	T3650	T3649	nummod	1,Fig.
R2398	T3651	T3649	punct	),Fig.
R2399	T3652	T3638	advmod	clearly,shows
R2400	T3653	T3654	mark	that,contain
R2401	T3654	T3638	ccomp	contain,shows
R2402	T3655	T3654	nsubj	RHAMM,contain
R2403	T3656	T3654	aux	does,contain
R2404	T3657	T3654	neg	not,contain
R2405	T3658	T3659	det	a,domain
R2406	T3659	T3654	dobj	domain,contain
R2407	T3660	T3659	compound	TACC,domain
R2408	T3661	T3654	cc	and,contain
R2409	T3662	T3663	advmod	instead,forms
R2410	T3663	T3654	conj	forms,contain
R2411	T3664	T3665	det	a,family
R2412	T3665	T3663	dobj	family,forms
R2413	T3666	T3665	amod	distinct,family
R2414	T3667	T3665	prep	of,family
R2415	T3668	T3667	pobj	proteins,of
R2416	T3669	T3663	prep	in,forms
R2417	T3670	T3671	det	the,superfamily
R2418	T3671	T3669	pobj	superfamily,in
R2419	T3672	T3673	amod	coiled,coil
R2420	T3673	T3671	compound	coil,superfamily
R2421	T3674	T3654	punct	", ",contain
R2422	T3675	T3654	cc	and,contain
R2423	T3676	T3654	conj	is,contain
R2424	T3677	T3676	neg	not,is
R2425	T3678	T3679	det	a,descendant
R2426	T3679	T3676	attr	descendant,is
R2427	T3680	T3679	amod	direct,descendant
R2428	T3681	T3679	prep	of,descendant
R2429	T3682	T3683	det	the,gene
R2430	T3683	T3681	pobj	gene,of
R2431	T3684	T3683	amod	ancestral,gene
R2432	T3685	T3683	compound	TACC,gene
R2433	T3686	T3638	punct	.,shows
R2443	T4146	T4145	prep	of,Evolution
R2444	T4147	T4148	det	the,segments
R2445	T4148	T4146	pobj	segments,of
R2446	T4149	T4148	amod	chromosomal,segments
R2447	T4150	T4148	acl	containing,segments
R2448	T4151	T4152	det	the,genes
R2449	T4152	T4150	dobj	genes,containing
R2450	T4153	T4152	compound	TACC,genes
R2451	T4155	T4156	det	The,tree
R2452	T4156	T4158	nsubj	tree,resembles
R2453	T4157	T4156	amod	phylogenetic,tree
R2454	T4159	T4156	prep	of,tree
R2455	T4160	T4161	det	the,genes
R2456	T4161	T4159	pobj	genes,of
R2457	T4162	T4161	compound	FGFR,genes
R2458	T4163	T4158	advmod	closely,resembles
R2459	T4164	T4158	dobj	that,resembles
R2460	T4165	T4164	prep	of,that
R2461	T4166	T4167	det	the,genes
R2462	T4167	T4165	pobj	genes,of
R2463	T4168	T4167	nmod	vertebrate,genes
R2464	T4169	T4167	nmod	TACC1,genes
R2465	T4170	T4169	punct	-,TACC1
R2466	T4171	T4169	nummod	3,TACC1
R2467	T4172	T4158	punct	.,resembles
R2468	T4174	T4175	advmod	Recently,revealed
R2469	T4176	T4175	punct	", ",revealed
R2470	T4177	T4178	amod	detailed,analyses
R2471	T4178	T4175	nsubj	analyses,revealed
R2472	T4179	T4178	prep	of,analyses
R2473	T4180	T4181	det	the,regions
R2474	T4181	T4179	pobj	regions,of
R2475	T4182	T4181	amod	chromosomal,regions
R2476	T4183	T4181	acl	containing,regions
R2477	T4184	T4185	det	the,family
R2478	T4185	T4183	dobj	family,containing
R2479	T4186	T4185	compound	FGFR,family
R2480	T4187	T4185	compound	gene,family
R2481	T4188	T4183	prep	in,containing
R2482	T4189	T4188	pobj	humans,in
R2483	T4190	T4189	punct	", ",humans
R2484	T4191	T4189	conj	mouse,humans
R2485	T4192	T4191	cc	and,mouse
R2486	T4193	T4194	det	the,arthopod
R2487	T4194	T4191	conj	arthopod,mouse
R2488	T4195	T4196	compound	D.,melanogaster
R2489	T4196	T4194	appos	melanogaster,arthopod
R2490	T4197	T4175	aux	have,revealed
R2491	T4198	T4199	det	the,conservation
R2492	T4199	T4175	dobj	conservation,revealed
R2493	T4200	T4199	prep	of,conservation
R2494	T4201	T4202	amod	paralogous,segments
R2495	T4202	T4200	pobj	segments,of
R2496	T4203	T4202	amod	chromosomal,segments
R2497	T4204	T4199	prep	between,conservation
R2498	T4205	T4206	det	these,organisms
R2499	T4206	T4204	pobj	organisms,between
R2500	T4207	T4208	punct	(,Table
R2501	T4208	T4175	parataxis	Table,revealed
R2502	T4209	T4208	dep	Fig.,Table
R2503	T4210	T4209	nummod	2,Fig.
R2504	T4211	T4208	punct	", ",Table
R2505	T4212	T4208	punct	[,Table
R2506	T4213	T4208	dep	13,Table
R2507	T4214	T4208	punct	],Table
R2508	T4215	T4208	punct	", ",Table
R2509	T4216	T4208	nummod	1,Table
R2510	T4217	T4208	punct	[,Table
R2511	T4218	T4208	advcl	see,Table
R2512	T4219	T4220	amod	Additional,file
R2513	T4220	T4218	dobj	file,see
R2514	T4221	T4220	nummod	1,file
R2515	T4222	T4208	punct	],Table
R2516	T4223	T4208	punct	),Table
R2517	T4224	T4175	punct	.,revealed
R2518	T4226	T4227	nsubj	This,provided
R2519	T4228	T4227	aux	has,provided
R2520	T4229	T4230	amod	further,support
R2521	T4230	T4227	dobj	support,provided
R2522	T4231	T4232	mark	that,duplicated
R2523	T4232	T4230	acl	duplicated,support
R2524	T4233	T4234	det	an,segment
R2525	T4234	T4232	nsubjpass	segment,duplicated
R2526	T4235	T4234	amod	ancient,segment
R2527	T4236	T4234	amod	chromosomal,segment
R2528	T4237	T4232	auxpass	was,duplicated
R2529	T4238	T4232	advmod	twice,duplicated
R2530	T4239	T4232	prep	during,duplicated
R2531	T4240	T4241	compound	vertebrate,evolution
R2532	T4241	T4239	pobj	evolution,during
R2533	T4242	T4232	punct	", ",duplicated
R2534	T4243	T4232	prep	with,duplicated
R2535	T4244	T4245	det	the,duplication
R2536	T4245	T4247	nsubj	duplication,occurring
R2537	T4246	T4245	amod	first,duplication
R2538	T4247	T4243	pcomp	occurring,with
R2539	T4248	T4249	dep	that,gave
R2540	T4249	T4245	relcl	gave,duplication
R2541	T4250	T4249	dobj	rise,gave
R2542	T4251	T4249	prep	to,gave
R2543	T4252	T4253	det	the,ancestors
R2544	T4253	T4251	pobj	ancestors,to
R2545	T4254	T4255	amod	human,chromosome
R2546	T4255	T4256	nmod	chromosome,ter
R2547	T4256	T4253	nmod	ter,ancestors
R2548	T4257	T4258	nmod	4p16,5q32
R2549	T4258	T4256	nmod	5q32,ter
R2550	T4259	T4258	punct	/,5q32
R2551	T4260	T4256	punct	-,ter
R2552	T4261	T4256	cc	and,ter
R2553	T4262	T4263	amod	human,chromosome
R2554	T4263	T4264	compound	chromosome,ter
R2555	T4264	T4256	conj	ter,ter
R2556	T4265	T4266	compound	8p,10q23
R2557	T4266	T4264	compound	10q23,ter
R2558	T4267	T4266	punct	/,10q23
R2559	T4268	T4264	punct	-,ter
R2560	T4269	T4247	prep	in,occurring
R2561	T4270	T4271	det	the,stages
R2562	T4271	T4269	pobj	stages,in
R2563	T4272	T4271	amod	early,stages
R2564	T4273	T4271	prep	after,stages
R2565	T4274	T4275	det	the,divergence
R2566	T4275	T4273	pobj	divergence,after
R2567	T4276	T4275	compound	invertebrate,divergence
R2568	T4277	T4227	punct	.,provided
R2569	T4279	T4280	nsubj	This,suggests
R2570	T4281	T4282	mark	that,arose
R2571	T4282	T4280	ccomp	arose,suggests
R2572	T4283	T4284	det	the,pair
R2573	T4284	T4282	nsubj	pair,arose
R2574	T4285	T4284	amod	ancestral,pair
R2575	T4286	T4287	compound	FGFR,TACC
R2576	T4287	T4284	compound	TACC,pair
R2577	T4288	T4287	punct	-,TACC
R2578	T4289	T4284	compound	gene,pair
R2579	T4290	T4291	advmod	most,probably
R2580	T4291	T4282	advmod	probably,arose
R2581	T4292	T4293	amod	prior,to
R2582	T4293	T4282	prep	to,arose
R2583	T4294	T4295	det	the,duplication
R2584	T4295	T4293	pobj	duplication,to
R2585	T4296	T4295	amod	initial,duplication
R2586	T4297	T4295	cc	and,duplication
R2587	T4298	T4299	amod	subsequent,divergence
R2588	T4299	T4295	conj	divergence,duplication
R2589	T4300	T4295	prep	of,duplication
R2590	T4301	T4302	det	these,segments
R2591	T4302	T4300	pobj	segments,of
R2592	T4303	T4302	amod	paralogous,segments
R2593	T4304	T4302	amod	chromosomal,segments
R2594	T4305	T4295	punct	", ",duplication
R2595	T4306	T4295	acl	estimated,duplication
R2596	T4307	T4308	aux	to,occurred
R2597	T4308	T4306	xcomp	occurred,estimated
R2598	T4309	T4308	aux	have,occurred
R2599	T4310	T4311	quantmod	687,155.7
R2600	T4311	T4313	npadvmod	155.7,MYA
R2601	T4312	T4311	punct	±,155.7
R2602	T4313	T4308	advmod	MYA,occurred
R2603	T4314	T4280	punct	.,suggests
R2604	T4316	T4317	nsubj	This,raised
R2605	T4318	T4317	aux	has,raised
R2606	T4319	T4320	det	the,suggestion
R2607	T4320	T4317	dobj	suggestion,raised
R2608	T4321	T4322	mark	that,reside
R2609	T4322	T4320	acl	reside,suggestion
R2610	T4323	T4324	det	a,gene
R2611	T4324	T4322	nsubj	gene,reside
R2612	T4325	T4324	amod	fourth,gene
R2613	T4326	T4324	compound	TACC,gene
R2614	T4327	T4324	prep	in,gene
R2615	T4328	T4327	pobj	vertebrates,in
R2616	T4329	T4322	aux	would,reside
R2617	T4330	T4322	prep	in,reside
R2618	T4331	T4332	det	the,region
R2619	T4332	T4330	pobj	region,in
R2620	T4333	T4332	amod	same,region
R2621	T4334	T4332	amod	chromosomal,region
R2622	T4335	T4332	prep	as,region
R2623	T4336	T4335	pobj	FGFR4,as
R2624	T4337	T4317	punct	.,raised
R2625	T4339	T4340	advmod	Indeed,used
R2626	T4341	T4342	det	this,hypothesis
R2627	T4342	T4340	nsubjpass	hypothesis,used
R2628	T4343	T4340	aux	has,used
R2629	T4344	T4340	auxpass	been,used
R2630	T4345	T4340	prep	in,used
R2631	T4346	T4345	pobj	support,in
R2632	T4347	T4346	prep	for,support
R2633	T4348	T4349	det	the,gene
R2634	T4349	T4347	pobj	gene,for
R2635	T4350	T4349	compound	RHAMM,gene
R2636	T4351	T4349	prep	as,gene
R2637	T4352	T4353	det	a,member
R2638	T4353	T4351	pobj	member,as
R2639	T4354	T4353	prep	of,member
R2640	T4355	T4356	det	the,family
R2641	T4356	T4354	pobj	family,of
R2642	T4357	T4356	compound	TACC,family
R2643	T4358	T4359	punct	[,10
R2644	T4359	T4340	parataxis	10,used
R2645	T4360	T4359	punct	],10
R2646	T4361	T4340	punct	.,used
R2647	T4363	T4364	amod	Human,RHAMM
R2648	T4364	T4365	nsubj	RHAMM,maps
R2649	T4366	T4365	prep	to,maps
R2650	T4367	T4368	compound	chromosome,5q32
R2651	T4368	T4366	pobj	5q32,to
R2652	T4369	T4365	prep	in,maps
R2653	T4370	T4371	det	a,region
R2654	T4371	T4369	pobj	region,in
R2655	T4372	T4371	acl	bounded,region
R2656	T4373	T4372	agent	by,bounded
R2657	T4374	T4373	pobj	GPX3,by
R2658	T4375	T4374	cc	and,GPX3
R2659	T4376	T4374	conj	NKX2E,GPX3
R2660	T4377	T4365	punct	.,maps
R2661	T4379	T4380	det	These,loci
R2662	T4380	T4381	nsubj	loci,separate
R2663	T4382	T4383	nummod	two,clusters
R2664	T4383	T4381	dobj	clusters,separate
R2665	T4384	T4383	prep	of,clusters
R2666	T4385	T4384	pobj	genes,of
R2667	T4386	T4383	prep	on,clusters
R2668	T4387	T4388	amod	human,chromosome
R2669	T4388	T4386	pobj	chromosome,on
R2670	T4389	T4388	nummod	5,chromosome
R2671	T4390	T4391	dep	that,are
R2672	T4391	T4383	relcl	are,clusters
R2673	T4392	T4391	acomp	paralogous,are
R2674	T4393	T4392	prep	with,paralogous
R2675	T4394	T4393	pobj	4p16,with
R2676	T4395	T4381	punct	.,separate
R2677	T4397	T4398	advmod	Interestingly,located
R2678	T4399	T4398	punct	", ",located
R2679	T4400	T4401	det	these,clusters
R2680	T4401	T4398	nsubjpass	clusters,located
R2681	T4402	T4401	nummod	three,clusters
R2682	T4403	T4398	auxpass	are,located
R2683	T4404	T4398	prep	on,located
R2684	T4405	T4406	amod	different,chromosomes
R2685	T4406	T4404	pobj	chromosomes,on
R2686	T4407	T4398	prep	in,located
R2687	T4408	T4407	pobj	mouse,in
R2688	T4409	T4408	cc	and,mouse
R2689	T4410	T4408	conj	rat,mouse
R2690	T4411	T4412	punct	(,Fig.
R2691	T4412	T4398	parataxis	Fig.,located
R2692	T4413	T4412	nummod	2,Fig.
R2693	T4414	T4412	punct	),Fig.
R2694	T4415	T4398	punct	", ",located
R2695	T4416	T4417	advmod	further,suggesting
R2696	T4417	T4398	advcl	suggesting,located
R2697	T4418	T4419	mark	that,transposed
R2698	T4419	T4417	ccomp	transposed,suggesting
R2699	T4420	T4421	det	this,cluster
R2700	T4421	T4419	nsubjpass	cluster,transposed
R2701	T4422	T4421	prep	of,cluster
R2702	T4423	T4422	pobj	genes,of
R2703	T4424	T4419	auxpass	was,transposed
R2704	T4425	T4419	prep	into,transposed
R2705	T4426	T4427	det	this,region
R2706	T4427	T4425	pobj	region,into
R2707	T4428	T4419	prep	after,transposed
R2708	T4429	T4430	det	the,divergence
R2709	T4430	T4428	pobj	divergence,after
R2710	T4431	T4432	compound	primate,rodent
R2711	T4432	T4430	compound	rodent,divergence
R2712	T4433	T4432	punct	/,rodent
R2713	T4434	T4398	punct	.,located
R2714	T4437	T4438	mark	Because,provide
R2715	T4438	T4446	advcl	provide,attempted
R2716	T4439	T4440	det	the,conservation
R2717	T4440	T4438	nsubj	conservation,provide
R2718	T4441	T4440	prep	of,conservation
R2719	T4442	T4443	compound	gene,order
R2720	T4443	T4441	pobj	order,of
R2721	T4444	T4438	aux	can,provide
R2722	T4445	T4438	advmod	also,provide
R2723	T4447	T4438	dobj	clues,provide
R2724	T4448	T4447	prep	to,clues
R2725	T4449	T4450	det	the,evolution
R2726	T4450	T4448	pobj	evolution,to
R2727	T4451	T4450	prep	of,evolution
R2728	T4452	T4453	compound	gene,regulation
R2729	T4453	T4451	pobj	regulation,of
R2730	T4454	T4446	punct	", ",attempted
R2731	T4455	T4446	nsubj	we,attempted
R2732	T4456	T4446	advmod	next,attempted
R2733	T4457	T4458	aux	to,trace
R2734	T4458	T4446	xcomp	trace,attempted
R2735	T4459	T4460	det	the,evolution
R2736	T4460	T4458	dobj	evolution,trace
R2737	T4461	T4460	prep	of,evolution
R2738	T4462	T4463	det	these,segments
R2739	T4463	T4461	pobj	segments,of
R2740	T4464	T4463	amod	paralogous,segments
R2741	T4465	T4458	prep	by,trace
R2742	T4466	T4465	pcomp	examining,by
R2743	T4467	T4468	det	the,genome
R2744	T4468	T4466	dobj	genome,examining
R2745	T4469	T4468	prep	of,genome
R2746	T4470	T4471	det	the,tunicate
R2747	T4471	T4469	pobj	tunicate,of
R2748	T4472	T4473	compound	C.,intestinalis
R2749	T4473	T4471	appos	intestinalis,tunicate
R2750	T4474	T4475	punct	[,11
R2751	T4475	T4471	parataxis	11,tunicate
R2752	T4476	T4475	punct	],11
R2753	T4477	T4468	cc	and,genome
R2754	T4478	T4479	det	the,genome
R2755	T4479	T4468	conj	genome,genome
R2756	T4480	T4481	amod	most,primitive
R2757	T4481	T4479	amod	primitive,genome
R2758	T4482	T4481	punct	"""",primitive
R2759	T4483	T4481	punct	"""",primitive
R2760	T4484	T4479	amod	compact,genome
R2761	T4485	T4479	compound	vertebrate,genome
R2762	T4486	T4479	acl	sequenced,genome
R2763	T4487	T4486	prep	to,sequenced
R2764	T4488	T4487	pobj	date,to
R2765	T4489	T4479	punct	", ",genome
R2766	T4490	T4491	compound	T.,rubripes
R2767	T4491	T4479	appos	rubripes,genome
R2768	T4492	T4493	punct	[,14
R2769	T4493	T4479	parataxis	14,genome
R2770	T4494	T4493	punct	],14
R2771	T4495	T4446	punct	.,attempted
R2772	T4497	T4498	mark	Although,assembled
R2773	T4498	T4501	advcl	assembled,confirmed
R2774	T4499	T4498	neg	not,assembled
R2775	T4500	T4498	advmod	fully,assembled
R2776	T4502	T4501	punct	", ",confirmed
R2777	T4503	T4501	nsubj	examination,confirmed
R2778	T4504	T4503	prep	of,examination
R2779	T4505	T4506	det	the,genome
R2780	T4506	T4504	pobj	genome,of
R2781	T4507	T4506	prep	of,genome
R2782	T4508	T4509	compound	T.,rubripes
R2783	T4509	T4507	pobj	rubripes,of
R2784	T4510	T4511	det	the,presence
R2785	T4511	T4501	dobj	presence,confirmed
R2786	T4512	T4511	prep	of,presence
R2787	T4513	T4514	amod	chromosomal,segments
R2788	T4514	T4512	pobj	segments,of
R2789	T4515	T4514	amod	paralogous,segments
R2790	T4516	T4515	prep	to,paralogous
R2791	T4517	T4516	pobj	those,to
R2792	T4518	T4517	acl	found,those
R2793	T4519	T4518	prep	in,found
R2794	T4520	T4521	amod	higher,vertebrates
R2795	T4521	T4519	pobj	vertebrates,in
R2796	T4522	T4523	punct	(,Fig.
R2797	T4523	T4501	parataxis	Fig.,confirmed
R2798	T4524	T4523	nummod	2,Fig.
R2799	T4525	T4523	punct	),Fig.
R2800	T4526	T4501	punct	.,confirmed
R2801	T4528	T4529	prep	For,found
R2802	T4530	T4528	pobj	instance,For
R2803	T4531	T4529	punct	", ",found
R2804	T4532	T4533	det	the,orthologues
R2805	T4533	T4529	nsubjpass	orthologues,found
R2806	T4534	T4533	prep	of,orthologues
R2807	T4535	T4534	pobj	GPRK2L,of
R2808	T4536	T4535	cc	and,GPRK2L
R2809	T4537	T4535	conj	RGS12,GPRK2L
R2810	T4538	T4529	auxpass	are,found
R2811	T4539	T4529	prep	on,found
R2812	T4540	T4541	compound	T.,rubripes
R2813	T4541	T4542	compound	rubripes,scaffold
R2814	T4542	T4539	pobj	scaffold,on
R2815	T4543	T4542	nummod	290,scaffold
R2816	T4544	T4542	punct	(,scaffold
R2817	T4545	T4542	appos	emb\|CAAB01000290.1,scaffold
R2818	T4546	T4542	punct	),scaffold
R2819	T4547	T4539	punct	", ",on
R2820	T4548	T4539	cc	and,on
R2821	T4549	T4539	conj	within,on
R2822	T4550	T4551	nummod	300,kb
R2823	T4551	T4549	pobj	kb,within
R2824	T4552	T4551	prep	of,kb
R2825	T4553	T4554	det	each,other
R2826	T4554	T4552	pobj	other,of
R2827	T4555	T4551	prep	in,kb
R2828	T4556	T4557	amod	human,4p16
R2829	T4557	T4555	pobj	4p16,in
R2830	T4558	T4529	punct	.,found
R2831	T4560	T4561	det	The,orthologues
R2832	T4561	T4564	nsubjpass	orthologues,located
R2833	T4562	T4563	compound	T.,rubripes
R2834	T4563	T4561	compound	rubripes,orthologues
R2835	T4565	T4561	prep	of,orthologues
R2836	T4566	T4565	pobj	FGFR3,of
R2837	T4567	T4561	punct	", ",orthologues
R2838	T4568	T4561	appos	LETM1,orthologues
R2839	T4569	T4568	cc	and,LETM1
R2840	T4570	T4568	conj	WHSC1,LETM1
R2841	T4571	T4564	auxpass	are,located
R2842	T4572	T4564	prep	on,located
R2843	T4573	T4574	det	the,scaffold
R2844	T4574	T4572	pobj	scaffold,on
R2845	T4575	T4574	amod	same,scaffold
R2846	T4576	T4577	nummod	166,kb
R2847	T4577	T4574	nmod	kb,scaffold
R2848	T4578	T4574	amod	genomic,scaffold
R2849	T4579	T4574	nummod	251,scaffold
R2850	T4580	T4574	punct	(,scaffold
R2851	T4581	T4574	appos	emb\|CAAB01000166.1,scaffold
R2852	T4582	T4574	punct	),scaffold
R2853	T4583	T4564	punct	.,located
R2854	T4585	T4586	advmod	Significantly,located
R2855	T4587	T4586	punct	", ",located
R2856	T4588	T4589	det	the,orthologues
R2857	T4589	T4586	nsubjpass	orthologues,located
R2858	T4590	T4589	nummod	three,orthologues
R2859	T4591	T4589	amod	human,orthologues
R2860	T4592	T4589	prep	of,orthologues
R2861	T4593	T4594	det	these,genes
R2862	T4594	T4592	pobj	genes,of
R2863	T4595	T4586	auxpass	are,located
R2864	T4596	T4586	advmod	also,located
R2865	T4597	T4586	prep	within,located
R2866	T4598	T4599	nummod	300,kb
R2867	T4599	T4597	pobj	kb,within
R2868	T4600	T4599	prep	of,kb
R2869	T4601	T4602	det	each,other
R2870	T4602	T4600	pobj	other,of
R2871	T4603	T4586	prep	on,located
R2872	T4604	T4603	pobj	4p16,on
R2873	T4605	T4586	punct	.,located
R2874	T4607	T4608	advmod	Furthermore,map
R2875	T4609	T4608	punct	", ",map
R2876	T4610	T4608	nsubj	TACC3,map
R2877	T4611	T4610	cc	and,TACC3
R2878	T4612	T4610	conj	FGFRL,TACC3
R2879	T4613	T4608	prep	to,map
R2880	T4614	T4615	det	the,scaffolds
R2881	T4615	T4613	pobj	scaffolds,to
R2882	T4616	T4615	amod	overlapping,scaffolds
R2883	T4617	T4618	nummod	1184,4669
R2884	T4618	T4615	appos	4669,scaffolds
R2885	T4619	T4618	punct	/,4669
R2886	T4620	T4618	punct	(,4669
R2887	T4621	T4618	appos	emb\|CAAB01004668,4669
R2888	T4622	T4618	punct	),4669
R2889	T4623	T4608	punct	.,map
R2890	T4625	T4626	advmod	Similarly,found
R2891	T4627	T4626	punct	", ",found
R2892	T4628	T4626	nsubjpass	elements,found
R2893	T4629	T4628	prep	of,elements
R2894	T4630	T4631	det	these,clusters
R2895	T4631	T4629	pobj	clusters,of
R2896	T4632	T4631	compound	gene,clusters
R2897	T4633	T4628	punct	", ",elements
R2898	T4634	T4628	acl	extending,elements
R2899	T4635	T4634	prep	from,extending
R2900	T4636	T4635	pobj	HMP19,from
R2901	T4637	T4634	prep	to,extending
R2902	T4638	T4637	pobj	GPRK6,to
R2903	T4639	T4634	prep	in,extending
R2904	T4640	T4641	amod	human,chromosome
R2905	T4641	T4642	compound	chromosome,ter
R2906	T4642	T4639	pobj	ter,in
R2907	T4643	T4642	compound	5q34,ter
R2908	T4644	T4642	punct	-,ter
R2909	T4645	T4626	auxpass	are,found
R2910	T4646	T4626	advmod	also,found
R2911	T4647	T4626	prep	in,found
R2912	T4648	T4649	det	the,pufferfish
R2913	T4649	T4647	pobj	pufferfish,in
R2914	T4650	T4626	punct	", ",found
R2915	T4651	T4626	prep	with,found
R2916	T4652	T4653	det	the,orthologues
R2917	T4653	T4651	pobj	orthologues,with
R2918	T4654	T4655	compound	T.,rubripes
R2919	T4655	T4653	compound	rubripes,orthologues
R2920	T4656	T4653	prep	of,orthologues
R2921	T4657	T4656	pobj	NSD1,of
R2922	T4658	T4653	punct	", ",orthologues
R2923	T4659	T4653	appos	FGFR4,orthologues
R2924	T4660	T4653	cc	and,orthologues
R2925	T4661	T4662	advmod	a,like
R2926	T4662	T4665	amod	like,mapping
R2927	T4663	T4662	npadvmod	RAB,like
R2928	T4664	T4662	punct	-,like
R2929	T4665	T4653	conj	mapping,orthologues
R2930	T4666	T4665	compound	gene,mapping
R2931	T4667	T4653	prep	on,orthologues
R2932	T4668	T4667	pobj	scaffold,on
R2933	T4669	T4668	nummod	407,scaffold
R2934	T4670	T4668	punct	(,scaffold
R2935	T4671	T4668	appos	emb\|CAAB01000407,scaffold
R2936	T4672	T4668	punct	),scaffold
R2937	T4673	T4626	punct	.,found
R2938	T4675	T4676	advmod	However,is
R2939	T4677	T4676	punct	", ",is
R2940	T4678	T4676	expl	there,is
R2941	T4679	T4680	det	no,evidence
R2942	T4680	T4676	attr	evidence,is
R2943	T4681	T4680	prep	for,evidence
R2944	T4682	T4683	det	a,gene
R2945	T4683	T4681	pobj	gene,for
R2946	T4684	T4683	acl	corresponding,gene
R2947	T4685	T4684	prep	to,corresponding
R2948	T4686	T4687	det	a,gene
R2949	T4687	T4685	pobj	gene,to
R2950	T4688	T4687	compound	TACC4,gene
R2951	T4689	T4676	prep	in,is
R2952	T4690	T4689	pobj	any,in
R2953	T4691	T4690	prep	of,any
R2954	T4692	T4693	det	these,clusters
R2955	T4693	T4691	pobj	clusters,of
R2956	T4694	T4676	punct	.,is
R2957	T4696	T4697	mark	As,noted
R2958	T4697	T4698	advcl	noted,indicate
R2959	T4699	T4697	advmod	above,noted
R2960	T4700	T4698	punct	", ",indicate
R2961	T4701	T4702	amod	phylogenetic,analysis
R2962	T4702	T4698	nsubj	analysis,indicate
R2963	T4703	T4702	prep	of,analysis
R2964	T4704	T4705	det	the,sequences
R2965	T4705	T4703	pobj	sequences,of
R2966	T4706	T4705	compound	TACC,sequences
R2967	T4707	T4708	mark	that,are
R2968	T4708	T4698	ccomp	are,indicate
R2969	T4709	T4708	expl	there,are
R2970	T4710	T4711	nummod	two,genes
R2971	T4711	T4708	attr	genes,are
R2972	T4712	T4713	npadvmod	TACC1,related
R2973	T4713	T4711	amod	related,genes
R2974	T4714	T4708	prep	in,are
R2975	T4715	T4716	det	the,pufferfish
R2976	T4716	T4714	pobj	pufferfish,in
R2977	T4717	T4698	punct	.,indicate
R2978	T4719	T4720	nsubjpass	trTACC1B,located
R2979	T4721	T4720	auxpass	is,located
R2980	T4722	T4720	prep	on,located
R2981	T4723	T4724	det	the,scaffold
R2982	T4724	T4722	pobj	scaffold,on
R2983	T4725	T4726	nummod	180,kb
R2984	T4726	T4724	compound	kb,scaffold
R2985	T4727	T4724	nummod	191,scaffold
R2986	T4728	T4724	punct	(,scaffold
R2987	T4729	T4724	appos	emb\|CAAB01000191.1,scaffold
R2988	T4730	T4724	punct	),scaffold
R2989	T4731	T4724	punct	", ",scaffold
R2990	T4732	T4733	dep	which,contains
R2991	T4733	T4724	relcl	contains,scaffold
R2992	T4734	T4733	advmod	also,contains
R2993	T4735	T4736	det	the,orthologues
R2994	T4736	T4733	dobj	orthologues,contains
R2995	T4737	T4736	prep	of,orthologues
R2996	T4738	T4739	amod	several,genes
R2997	T4739	T4737	pobj	genes,of
R2998	T4740	T4739	acl	located,genes
R2999	T4741	T4740	prep	in,located
R3000	T4742	T4743	amod	human,8p21
R3001	T4743	T4741	pobj	8p21,in
R3002	T4744	T4743	compound	chromosome,8p21
R3003	T4745	T4743	punct	-,8p21
R3004	T4746	T4743	nummod	11,8p21
R3005	T4747	T4720	punct	.,located
R3006	T4749	T4750	advmod	Thus,represents
R3007	T4751	T4750	punct	", ",represents
R3008	T4752	T4753	det	this,scaffold
R3009	T4753	T4750	nsubj	scaffold,represents
R3010	T4754	T4755	det	the,segment
R3011	T4755	T4750	dobj	segment,represents
R3012	T4756	T4757	advmod	more,developed
R3013	T4757	T4755	amod	developed,segment
R3014	T4758	T4757	punct	"""",developed
R3015	T4759	T4757	punct	"""",developed
R3016	T4760	T4755	nmod	TACC1,segment
R3017	T4761	T4755	amod	chromosomal,segment
R3018	T4762	T4763	dep	that,is
R3019	T4763	T4755	relcl	is,segment
R3020	T4764	T4763	acomp	evident,is
R3021	T4765	T4763	prep	in,is
R3022	T4766	T4767	amod	higher,vertebrates
R3023	T4767	T4765	pobj	vertebrates,in
R3024	T4768	T4750	punct	.,represents
R3025	T4770	T4771	prep	On,located
R3026	T4772	T4773	det	the,hand
R3027	T4773	T4770	pobj	hand,On
R3028	T4774	T4773	amod	other,hand
R3029	T4775	T4771	punct	", ",located
R3030	T4776	T4777	det	the,gene
R3031	T4777	T4771	nsubjpass	gene,located
R3032	T4778	T4777	compound	trTACC1A,gene
R3033	T4779	T4771	auxpass	is,located
R3034	T4780	T4771	prep	in,located
R3035	T4781	T4782	det	the,scaffold
R3036	T4782	T4780	pobj	scaffold,in
R3037	T4783	T4784	nummod	396,kb
R3038	T4784	T4782	compound	kb,scaffold
R3039	T4785	T4782	nummod	12,scaffold
R3040	T4786	T4782	punct	(,scaffold
R3041	T4787	T4782	appos	emb\|CAAB010012.1,scaffold
R3042	T4788	T4782	punct	),scaffold
R3043	T4789	T4771	punct	.,located
R3044	T4791	T4792	det	This,scaffold
R3045	T4792	T4793	nsubj	scaffold,contains
R3046	T4794	T4793	advmod	also,contains
R3047	T4795	T4796	det	the,orthologues
R3048	T4796	T4793	dobj	orthologues,contains
R3049	T4797	T4798	compound	T.,rubripes
R3050	T4798	T4796	compound	rubripes,orthologues
R3051	T4799	T4796	prep	of,orthologues
R3052	T4800	T4799	pobj	MSX1,of
R3053	T4801	T4800	punct	", ",MSX1
R3054	T4802	T4800	conj	STX18,MSX1
R3055	T4803	T4802	punct	", ",STX18
R3056	T4804	T4802	conj	D4S234E,STX18
R3057	T4805	T4804	cc	and,D4S234E
R3058	T4806	T4807	det	the,gene
R3059	T4807	T4804	conj	gene,D4S234E
R3060	T4808	T4807	amod	predicted,gene
R3061	T4809	T4807	appos	LOC118711,gene
R3062	T4810	T4793	punct	", ",contains
R3063	T4811	T4793	prep	in,contains
R3064	T4812	T4811	pobj	addition,in
R3065	T4813	T4812	prep	to,addition
R3066	T4814	T4813	pobj	sequences,to
R3067	T4815	T4814	prep	with,sequences
R3068	T4816	T4815	pobj	homology,with
R3069	T4817	T4816	prep	to,homology
R3070	T4818	T4817	pobj	LOXL,to
R3071	T4819	T4818	punct	", ",LOXL
R3072	T4820	T4818	conj	EVC,LOXL
R3073	T4821	T4820	punct	", ",EVC
R3074	T4822	T4820	conj	LOC159291,EVC
R3075	T4823	T4822	punct	", ",LOC159291
R3076	T4824	T4822	cc	and,LOC159291
R3077	T4825	T4826	det	the,family
R3078	T4826	T4822	conj	family,LOC159291
R3079	T4827	T4826	compound	LDB,family
R3080	T4828	T4793	punct	.,contains
R3081	T4830	T4831	advmod	Thus,contains
R3082	T4832	T4831	punct	", ",contains
R3083	T4833	T4831	nsubj	scaffold,contains
R3084	T4834	T4833	nummod	12,scaffold
R3085	T4835	T4831	dobj	genes,contains
R3086	T4836	T4835	acl	found,genes
R3087	T4837	T4836	prep	in,found
R3088	T4838	T4839	det	the,regions
R3089	T4839	T4837	pobj	regions,in
R3090	T4840	T4839	prep	of,regions
R3091	T4841	T4842	amod	human,4
R3092	T4842	T4840	pobj	4,of
R3093	T4843	T4842	nmod	chromosome,4
R3094	T4844	T4842	cc	and,4
R3095	T4845	T4842	conj	10,4
R3096	T4846	T4847	dep	that,contain
R3097	T4847	T4835	relcl	contain,genes
R3098	T4848	T4847	advmod	also,contain
R3099	T4849	T4850	det	the,loci
R3100	T4850	T4847	dobj	loci,contain
R3101	T4851	T4850	prep	for,loci
R3102	T4852	T4851	pobj	TACC3,for
R3103	T4853	T4852	cc	and,TACC3
R3104	T4854	T4852	conj	TACC2,TACC3
R3105	T4855	T4847	punct	", ",contain
R3106	T4856	T4847	advmod	respectively,contain
R3107	T4857	T4831	punct	", ",contains
R3108	T4858	T4831	cc	and,contains
R3109	T4859	T4860	aux	may,resemble
R3110	T4860	T4831	conj	resemble,contains
R3111	T4861	T4860	advmod	therefore,resemble
R3112	T4862	T4863	advmod	more,closely
R3113	T4863	T4860	advmod	closely,resemble
R3114	T4864	T4865	det	the,organization
R3115	T4865	T4860	dobj	organization,resemble
R3116	T4866	T4865	amod	genomic,organization
R3117	T4867	T4865	acl	resulting,organization
R3118	T4868	T4867	prep	from,resulting
R3119	T4869	T4870	det	the,duplication
R3120	T4870	T4868	pobj	duplication,from
R3121	T4871	T4870	amod	initial,duplication
R3122	T4872	T4870	prep	of,duplication
R3123	T4873	T4874	det	the,segment
R3124	T4874	T4872	pobj	segment,of
R3125	T4875	T4874	amod	ancestral,segment
R3126	T4876	T4874	amod	paralogous,segment
R3127	T4877	T4874	amod	chromosomal,segment
R3128	T4878	T4831	punct	.,contains
R3129	T4880	T4881	amod	Conserved,clusters
R3130	T4881	T4883	nsubj	clusters,result
R3131	T4882	T4881	amod	paralogous,clusters
R3132	T4884	T4883	aux	may,result
R3133	T4885	T4883	prep	from,result
R3134	T4886	T4887	det	the,clustering
R3135	T4887	T4885	pobj	clustering,from
R3136	T4888	T4887	amod	initial,clustering
R3137	T4889	T4887	prep	of,clustering
R3138	T4890	T4891	det	the,genes
R3139	T4891	T4889	pobj	genes,of
R3140	T4892	T4887	prep	in,clustering
R3141	T4893	T4894	det	a,contig
R3142	T4894	T4892	pobj	contig,in
R3143	T4895	T4896	advmod	relatively,small
R3144	T4896	T4894	amod	small,contig
R3145	T4897	T4894	amod	ancestral,contig
R3146	T4898	T4894	amod	genomic,contig
R3147	T4899	T4883	punct	.,result
R3148	T4901	T4902	det	Some,evidence
R3149	T4902	T4903	nsubj	evidence,is
R3150	T4904	T4902	prep	for,evidence
R3151	T4905	T4906	det	the,existence
R3152	T4906	T4904	pobj	existence,for
R3153	T4907	T4906	prep	of,existence
R3154	T4908	T4909	punct	"""",protoclusters
R3155	T4909	T4907	pobj	protoclusters,of
R3156	T4910	T4909	punct	"""",protoclusters
R3157	T4911	T4912	dep	that,correspond
R3158	T4912	T4909	relcl	correspond,protoclusters
R3159	T4913	T4912	aux	could,correspond
R316	T703	T704	det	The,evolution
R3160	T4914	T4912	prep	to,correspond
R3161	T4915	T4916	det	the,segments
R3162	T4916	T4914	pobj	segments,to
R3163	T4917	T4916	amod	paralogous,segments
R3164	T4918	T4916	amod	chromosomal,segments
R3165	T4919	T4916	acl	noted,segments
R3166	T4920	T4919	prep	in,noted
R3167	T4921	T4922	amod	higher,vertebrates
R3168	T4922	T4920	pobj	vertebrates,in
R3169	T4923	T4903	acomp	present,is
R317	T704	T705	nsubjpass	evolution,associated
R3170	T4924	T4903	prep	in,is
R3171	T4925	T4926	det	the,genome
R3172	T4926	T4924	pobj	genome,in
R3173	T4927	T4926	prep	of,genome
R3174	T4928	T4929	det	the,urochordate
R3175	T4929	T4927	pobj	urochordate,of
R3176	T4930	T4931	compound	C.,intestinalis
R3177	T4931	T4929	appos	intestinalis,urochordate
R3178	T4932	T4933	punct	[,11
R3179	T4933	T4903	parataxis	11,is
R318	T706	T704	prep	of,evolution
R3180	T4934	T4933	punct	],11
R3181	T4935	T4903	punct	.,is
R3182	T4937	T4938	prep	For,cluster
R3183	T4939	T4937	pobj	instance,For
R3184	T4940	T4938	punct	", ",cluster
R3185	T4941	T4942	det	the,orthologues
R3186	T4942	T4938	nsubj	orthologues,cluster
R3187	T4943	T4942	prep	of,orthologues
R3188	T4944	T4943	pobj	FGFR,of
R3189	T4945	T4944	punct	", ",FGFR
R319	T707	T708	amod	complex,organisms
R3190	T4946	T4944	cc	and,FGFR
R3191	T4947	T4944	conj	WHSC1,FGFR
R3192	T4948	T4942	punct	", ",orthologues
R3193	T4949	T4950	compound	carboxypeptidase,Z
R3194	T4950	T4942	appos	Z,orthologues
R3195	T4951	T4950	cc	and,Z
R3196	T4952	T4950	conj	FLJ25359,Z
R3197	T4953	T4938	prep	within,cluster
R3198	T4954	T4955	det	an,region
R3199	T4955	T4953	pobj	region,within
R320	T708	T706	pobj	organisms,of
R3200	T4956	T4957	nummod	85,kb
R3201	T4957	T4955	compound	kb,region
R3202	T4958	T4955	prep	of,region
R3203	T4959	T4960	det	the,genome
R3204	T4960	T4958	pobj	genome,of
R3205	T4961	T4962	compound	C.,intestinalis
R3206	T4962	T4960	compound	intestinalis,genome
R3207	T4963	T4938	cc	and,cluster
R3208	T4964	T4965	det	the,orthologues
R3209	T4965	T4967	nsubjpass	orthologues,maintained
R321	T709	T705	aux	has,associated
R3210	T4966	T4965	amod	human,orthologues
R3211	T4967	T4938	conj	maintained,cluster
R3212	T4968	T4967	auxpass	are,maintained
R3213	T4969	T4967	advmod	still,maintained
R3214	T4970	T4967	prep	in,maintained
R3215	T4971	T4972	amod	paralogous,segments
R3216	T4972	T4970	pobj	segments,in
R3217	T4973	T4972	prep	of,segments
R3218	T4974	T4973	pobj	4p16,of
R3219	T4975	T4974	punct	", ",4p16
R322	T710	T705	auxpass	been,associated
R3220	T4976	T4974	conj	8p,4p16
R3221	T4977	T4976	cc	and,8p
R3222	T4978	T4976	conj	10q,8p
R3223	T4979	T4980	punct	(,Fig.
R3224	T4980	T4967	parataxis	Fig.,maintained
R3225	T4981	T4980	nummod	3,Fig.
R3226	T4982	T4980	punct	", ",Fig.
R3227	T4983	T4980	punct	[,Fig.
R3228	T4984	T4980	advcl	see,Fig.
R3229	T4985	T4986	amod	Additional,file
R323	T711	T705	prep	with,associated
R3230	T4986	T4984	dobj	file,see
R3231	T4987	T4986	nummod	1,file
R3232	T4988	T4980	punct	],Fig.
R3233	T4989	T4980	punct	),Fig.
R3234	T4990	T4938	punct	.,cluster
R3235	T4992	T4993	advmod	However,noted
R3236	T4994	T4993	punct	", ",noted
R3237	T4995	T4993	nsubjpass	it,noted
R3238	T4996	T4993	aux	should,noted
R3239	T4997	T4993	auxpass	be,noted
R324	T712	T713	det	the,generation
R3240	T4998	T4999	mark	that,locate
R3241	T4999	T4993	ccomp	locate,noted
R3242	T5000	T5001	det	no,clusters
R3243	T5001	T4999	nsubjpass	clusters,locate
R3244	T5002	T5001	prep	of,clusters
R3245	T5003	T5002	pobj	genes,of
R3246	T5004	T5003	prep	from,genes
R3247	T5005	T5006	det	the,segments
R3248	T5006	T5004	pobj	segments,from
R3249	T5007	T5006	nmod	vertebrate,segments
R325	T713	T711	pobj	generation,with
R3250	T5008	T5006	amod	paralogous,segments
R3251	T5009	T4999	auxpass	are,locate
R3252	T5010	T4999	advmod	close,locate
R3253	T5011	T5010	prep	to,close
R3254	T5012	T5013	det	the,genes
R3255	T5013	T5011	pobj	genes,to
R3256	T5014	T5013	nmod	TACC,genes
R3257	T5015	T5014	cc	or,TACC
R3258	T5016	T5014	conj	RHAMM,TACC
R3259	T5017	T5013	prep	of,genes
R326	T714	T713	prep	of,generation
R3260	T5018	T5019	compound	C.,intestinalis
R3261	T5019	T5017	pobj	intestinalis,of
R3262	T5020	T4999	punct	", ",locate
R3263	T5021	T4999	advcl	indicating,locate
R3264	T5022	T5023	mark	that,formed
R3265	T5023	T5021	ccomp	formed,indicating
R3266	T5024	T5025	det	the,formation
R3267	T5025	T5023	nsubj	formation,formed
R3268	T5026	T5025	prep	of,formation
R3269	T5027	T5028	det	the,segments
R327	T715	T716	compound	gene,families
R3270	T5028	T5026	pobj	segments,of
R3271	T5029	T5030	advmod	much,larger
R3272	T5030	T5028	amod	larger,segments
R3273	T5031	T5028	amod	paralogous,segments
R3274	T5032	T5028	acl	encompassing,segments
R3275	T5033	T5034	det	the,genes
R3276	T5034	T5032	dobj	genes,encompassing
R3277	T5035	T5036	compound	FGFR,TACC
R3278	T5036	T5034	compound	TACC,genes
R3279	T5037	T5036	punct	-,TACC
R328	T716	T714	pobj	families,of
R3280	T5038	T5023	advmod	later,formed
R3281	T5039	T5038	prep	in,later
R3282	T5040	T5041	amod	evolutionary,time
R3283	T5041	T5039	pobj	time,in
R3284	T5042	T5023	punct	", ",formed
R3285	T5043	T5023	cc	or,formed
R3286	T5044	T5045	advmod	conversely,been
R3287	T5045	T5023	conj	been,formed
R3288	T5046	T5045	aux	have,been
R3289	T5047	T5045	acomp	subject,been
R329	T717	T705	prep	by,associated
R3290	T5048	T5047	prep	to,subject
R3291	T5049	T5050	amod	extensive,rearrangement
R3292	T5050	T5048	pobj	rearrangement,to
R3293	T5051	T5045	prep	in,been
R3294	T5052	T5051	pobj	tunicates,in
R3295	T5053	T4993	punct	.,noted
R3296	T5055	T5056	prep	In,provides
R3297	T5057	T5055	pobj	combination,In
R3298	T5058	T5057	prep	with,combination
R3299	T5059	T5060	det	the,examination
R330	T718	T719	det	the,duplication
R3300	T5060	T5058	pobj	examination,with
R3301	T5061	T5060	prep	of,examination
R3302	T5062	T5063	det	the,genome
R3303	T5063	T5061	pobj	genome,of
R3304	T5064	T5065	compound	T.,rubripes
R3305	T5065	T5063	compound	rubripes,genome
R3306	T5066	T5056	punct	", ",provides
R3307	T5067	T5056	nsubj	this,provides
R3308	T5068	T5056	advmod	also,provides
R3309	T5069	T5070	amod	additional,evidence
R331	T719	T717	pobj	duplication,by
R3310	T5070	T5056	dobj	evidence,provides
R3311	T5071	T5072	mark	that,include
R3312	T5072	T5070	advcl	include,evidence
R3313	T5073	T5072	preconj	either,include
R3314	T5074	T5075	det	the,round
R3315	T5075	T5072	nsubj	round,include
R3316	T5076	T5075	amod	second,round
R3317	T5077	T5075	prep	of,round
R3318	T5078	T5077	pobj	duplication,of
R3319	T5079	T5078	prep	of,duplication
R332	T720	T719	amod	continual,duplication
R3320	T5080	T5081	det	the,segment
R3321	T5081	T5079	pobj	segment,of
R3322	T5082	T5081	amod	chromosomal,segment
R3323	T5083	T5084	dep	that,contained
R3324	T5084	T5081	relcl	contained,segment
R3325	T5085	T5086	det	the,ancestor
R3326	T5086	T5084	dobj	ancestor,contained
R3327	T5087	T5086	nmod	FGFR3,ancestor
R3328	T5088	T5087	punct	/,FGFR3
R3329	T5089	T5087	nummod	4,FGFR3
R333	T721	T719	prep	of,duplication
R3330	T5090	T5072	aux	did,include
R3331	T5091	T5072	neg	not,include
R3332	T5092	T5093	det	a,gene
R3333	T5093	T5072	dobj	gene,include
R3334	T5094	T5093	compound	TACC,gene
R3335	T5095	T5072	punct	", ",include
R3336	T5096	T5072	cc	or,include
R3337	T5097	T5098	mark	that,lost
R3338	T5098	T5072	conj	lost,include
R3339	T5099	T5100	predet	such,gene
R334	T722	T723	det	an,set
R3340	T5100	T5098	nsubjpass	gene,lost
R3341	T5101	T5100	det	a,gene
R3342	T5102	T5098	auxpass	was,lost
R3343	T5103	T5104	advmod	very,early
R3344	T5104	T5098	advmod	early,lost
R3345	T5105	T5104	prep	in,early
R3346	T5106	T5107	compound	vertebrate,evolution
R3347	T5107	T5105	pobj	evolution,in
R3348	T5108	T5098	punct	", ",lost
R3349	T5109	T5098	advmod	prior,lost
R335	T723	T721	pobj	set,of
R3350	T5110	T5109	prep	to,prior
R3351	T5111	T5112	det	the,divergence
R3352	T5112	T5110	pobj	divergence,to
R3353	T5113	T5112	prep	of,divergence
R3354	T5114	T5115	det	the,lineages
R3355	T5115	T5113	pobj	lineages,of
R3356	T5116	T5115	compound	Gnanthostome,lineages
R3357	T5117	T5056	punct	.,provides
R3358	T5119	T5120	advmod	However,await
R3359	T5121	T5120	punct	", ",await
R336	T724	T723	amod	initial,set
R3360	T5122	T5123	det	the,resolution
R3361	T5123	T5120	nsubj	resolution,await
R3362	T5124	T5123	amod	final,resolution
R3363	T5125	T5123	prep	of,resolution
R3364	T5126	T5127	det	the,evolution
R3365	T5127	T5125	pobj	evolution,of
R3366	T5128	T5127	amod	initial,evolution
R3367	T5129	T5127	prep	of,evolution
R3368	T5130	T5131	det	these,segment
R3369	T5131	T5129	pobj	segment,of
R337	T725	T726	advmod	relatively,small
R3370	T5132	T5131	amod	paralogous,segment
R3371	T5133	T5120	aux	will,await
R3372	T5134	T5135	det	the,sequencing
R3373	T5135	T5120	dobj	sequencing,await
R3374	T5136	T5135	prep	of,sequencing
R3375	T5137	T5138	det	the,genomes
R3376	T5138	T5136	pobj	genomes,of
R3377	T5139	T5138	nmod	amphioxus,genomes
R3378	T5140	T5139	cc	and,amphioxus
R3379	T5141	T5139	conj	lamprey,amphioxus
R338	T726	T723	amod	small,set
R3380	T5142	T5138	punct	", ",genomes
R3381	T5143	T5144	dep	which,have
R3382	T5144	T5138	relcl	have,genomes
R3383	T5145	T5144	advmod	only,have
R3384	T5146	T5147	nummod	one,gene
R3385	T5147	T5144	dobj	gene,have
R3386	T5148	T5147	compound	FGFR,gene
R3387	T5149	T5144	punct	", ",have
R3388	T5150	T5144	cc	and,have
R3389	T5151	T5152	advmod	therefore,contain
R339	T727	T723	prep	of,set
R3390	T5152	T5144	conj	contain,have
R3391	T5153	T5152	aux	should,contain
R3392	T5154	T5152	advmod	only,contain
R3393	T5155	T5156	nummod	one,copy
R3394	T5156	T5152	dobj	copy,contain
R3395	T5157	T5156	prep	of,copy
R3396	T5158	T5159	det	the,genes
R3397	T5159	T5157	pobj	genes,of
R3398	T5160	T5159	amod	other,genes
R3399	T5161	T5159	amod	corresponding,genes
R340	T728	T729	amod	ancestral,genes
R3400	T5162	T5152	prep	in,contain
R3401	T5163	T5164	det	this,segment
R3402	T5164	T5162	pobj	segment,in
R3403	T5165	T5164	amod	conserved,segment
R3404	T5166	T5120	punct	.,await
R3405	T5507	T5508	amod	Comparative,structure
R3406	T5509	T5508	amod	genomic,structure
R3407	T5510	T5508	prep	of,structure
R3408	T5511	T5512	det	the,family
R3409	T5512	T5510	pobj	family,of
R341	T729	T727	pobj	genes,of
R3410	T5513	T5512	compound	TACC,family
R3411	T5515	T5516	det	The,sequences
R3412	T5516	T5519	nsubj	sequences,extracted
R3413	T5517	T5516	amod	genomic,sequences
R3414	T5518	T5516	compound	DNA,sequences
R3415	T5520	T5516	acl	corresponding,sequences
R3416	T5521	T5520	prep	to,corresponding
R3417	T5522	T5523	det	the,genes
R3418	T5523	T5521	pobj	genes,to
R3419	T5524	T5523	amod	orthologous,genes
R342	T730	T705	punct	.,associated
R3420	T5525	T5523	compound	TACC,genes
R3421	T5526	T5523	prep	of,genes
R3422	T5527	T5526	pobj	human,of
R3423	T5528	T5527	punct	", ",human
R3424	T5529	T5527	conj	mouse,human
R3425	T5530	T5529	punct	", ",mouse
R3426	T5531	T5529	conj	rat,mouse
R3427	T5532	T5531	punct	", ",rat
R3428	T5533	T5531	conj	pufferfish,rat
R3429	T5534	T5533	punct	", ",pufferfish
R343	T732	T733	prep	Through,evolved
R3430	T5535	T5536	compound	C.,intestinalis
R3431	T5536	T5533	conj	intestinalis,pufferfish
R3432	T5537	T5536	punct	", ",intestinalis
R3433	T5538	T5539	compound	D.,melanogaster
R3434	T5539	T5536	conj	melanogaster,intestinalis
R3435	T5540	T5539	cc	and,melanogaster
R3436	T5541	T5542	compound	C.,elegans
R3437	T5542	T5539	conj	elegans,melanogaster
R3438	T5543	T5519	aux	were,extracted
R3439	T5544	T5519	cc	and,extracted
R344	T734	T735	det	this,process
R3440	T5545	T5519	conj	analyzed,extracted
R3441	T5546	T5545	prep	by,analyzed
R3442	T5547	T5546	pobj	Genescan,by
R3443	T5548	T5547	cc	and,Genescan
R3444	T5549	T5547	conj	BLAST,Genescan
R3445	T5550	T5551	aux	to,determine
R3446	T5551	T5519	advcl	determine,extracted
R3447	T5552	T5553	det	the,structure
R3448	T5553	T5551	dobj	structure,determine
R3449	T5554	T5553	amod	genomic,structure
R345	T735	T732	pobj	process,Through
R3450	T5555	T5553	prep	of,structure
R3451	T5556	T5557	det	each,gene
R3452	T5557	T5555	pobj	gene,of
R3453	T5558	T5557	compound	TACC,gene
R3454	T5559	T5519	punct	.,extracted
R3455	T5561	T5562	prep	In,added
R3456	T5563	T5564	det	some,cases
R3457	T5564	T5561	pobj	cases,In
R3458	T5565	T5562	punct	", ",added
R3459	T5566	T5562	prep	for,added
R346	T736	T735	punct	", ",process
R3460	T5567	T5566	pobj	rat,for
R3461	T5568	T5567	cc	and,rat
R3462	T5569	T5567	conj	pufferfish,rat
R3463	T5570	T5562	punct	", ",added
R3464	T5571	T5562	nsubjpass	exons,added
R3465	T5572	T5562	auxpass	were,added
R3466	T5573	T5562	cc	or,added
R3467	T5574	T5562	conj	modified,added
R3468	T5575	T5574	prep	based,modified
R3469	T5576	T5575	prep	on,based
R347	T737	T735	acl	followed,process
R3470	T5577	T5578	det	the,similarity
R3471	T5578	T5576	pobj	similarity,on
R3472	T5579	T5578	amod	best,similarity
R3473	T5580	T5578	prep	of,similarity
R3474	T5581	T5582	amod	translated,peptides
R3475	T5582	T5580	pobj	peptides,of
R3476	T5583	T5578	prep	to,similarity
R3477	T5584	T5585	det	the,proteins
R3478	T5585	T5583	pobj	proteins,to
R3479	T5586	T5585	amod	corresponding,proteins
R348	T738	T737	agent	by,followed
R3480	T5587	T5585	nmod	mouse,proteins
R3481	T5588	T5587	cc	and,mouse
R3482	T5589	T5587	conj	human,mouse
R3483	T5590	T5562	punct	.,added
R3484	T5592	T5593	prep	For,used
R3485	T5594	T5592	pobj	regions,For
R3486	T5595	T5594	prep	with,regions
R3487	T5596	T5597	amod	low,similarity
R3488	T5597	T5595	pobj	similarity,with
R3489	T5598	T5597	compound	sequence,similarity
R349	T739	T740	amod	subsequent,mutation
R3490	T5599	T5594	prep	in,regions
R3491	T5600	T5601	compound	T.,rubripes
R3492	T5601	T5599	pobj	rubripes,in
R3493	T5602	T5593	punct	", ",used
R3494	T5603	T5604	amod	genomic,sequences
R3495	T5604	T5593	nsubjpass	sequences,used
R3496	T5605	T5604	prep	from,sequences
R3497	T5606	T5607	det	the,pufferfish
R3498	T5607	T5605	pobj	pufferfish,from
R3499	T5608	T5609	amod	fresh,water
R350	T740	T738	pobj	mutation,by
R3500	T5609	T5607	compound	water,pufferfish
R3501	T5610	T5607	punct	", ",pufferfish
R3502	T5611	T5612	compound	Tetraodon,nigroviridis
R3503	T5612	T5607	appos	nigroviridis,pufferfish
R3504	T5613	T5593	auxpass	were,used
R3505	T5614	T5593	prep	as,used
R3506	T5615	T5616	amod	additional,means
R3507	T5616	T5614	pobj	means,as
R3508	T5617	T5618	aux	to,verify
R3509	T5618	T5616	advcl	verify,means
R351	T741	T740	punct	", ",mutation
R3510	T5619	T5620	det	the,exons
R3511	T5620	T5618	dobj	exons,verify
R3512	T5621	T5620	amod	predicted,exons
R3513	T5622	T5593	punct	.,used
R3514	T5624	T5625	det	The,structure
R3515	T5625	T5627	nsubjpass	structure,depicted
R3516	T5626	T5625	amod	general,structure
R3517	T5628	T5625	prep	of,structure
R3518	T5629	T5630	det	the,genes
R3519	T5630	T5628	pobj	genes,of
R352	T742	T740	conj	reduplication,mutation
R3520	T5631	T5630	compound	TACC,genes
R3521	T5632	T5630	cc	and,genes
R3522	T5633	T5630	conj	proteins,genes
R3523	T5634	T5627	auxpass	is,depicted
R3524	T5635	T5627	prep	in,depicted
R3525	T5636	T5635	pobj	Fig.,in
R3526	T5637	T5636	nummod	4,Fig.
R3527	T5638	T5627	punct	.,depicted
R3528	T5640	T5641	det	The,feature
R3529	T5641	T5644	nsubjpass	feature,located
R353	T743	T742	cc	and,reduplication
R3530	T5642	T5641	amod	main,feature
R3531	T5643	T5641	amod	conserved,feature
R3532	T5645	T5641	prep	of,feature
R3533	T5646	T5647	det	the,family
R3534	T5647	T5645	pobj	family,of
R3535	T5648	T5647	compound	TACC,family
R3536	T5649	T5641	punct	", ",feature
R3537	T5650	T5651	det	the,domain
R3538	T5651	T5641	appos	domain,feature
R3539	T5652	T5651	compound	TACC,domain
R354	T744	T745	compound	exon,shuffling
R3540	T5653	T5644	punct	", ",located
R3541	T5654	T5644	auxpass	is,located
R3542	T5655	T5644	prep	at,located
R3543	T5656	T5657	det	the,terminus
R3544	T5657	T5655	pobj	terminus,at
R3545	T5658	T5657	compound	carboxy,terminus
R3546	T5659	T5657	prep	of,terminus
R3547	T5660	T5661	det	the,protein
R3548	T5661	T5659	pobj	protein,of
R3549	T5662	T5644	punct	.,located
R355	T745	T742	conj	shuffling,reduplication
R3550	T5664	T5665	prep	In,comprises
R3551	T5666	T5667	det	the,case
R3552	T5667	T5664	pobj	case,In
R3553	T5668	T5667	prep	of,case
R3554	T5669	T5670	det	the,protein
R3555	T5670	T5668	pobj	protein,of
R3556	T5671	T5672	compound	C.,elegans
R3557	T5672	T5670	compound	elegans,protein
R3558	T5673	T5670	compound	TAC,protein
R3559	T5674	T5665	punct	", ",comprises
R356	T746	T740	prep	between,mutation
R3560	T5675	T5676	det	this,structure
R3561	T5676	T5665	nsubj	structure,comprises
R3562	T5677	T5678	det	the,majority
R3563	T5678	T5665	dobj	majority,comprises
R3564	T5679	T5678	prep	of,majority
R3565	T5680	T5681	det	the,protein
R3566	T5681	T5679	pobj	protein,of
R3567	T5682	T5665	cc	and,comprises
R3568	T5683	T5684	auxpass	is,encoded
R3569	T5684	T5665	conj	encoded,comprises
R357	T747	T748	compound	gene,families
R3570	T5685	T5684	agent	by,encoded
R3571	T5686	T5685	pobj	two,by
R3572	T5687	T5686	prep	of,two
R3573	T5688	T5689	det	the,exons
R3574	T5689	T5687	pobj	exons,of
R3575	T5690	T5689	nummod	three,exons
R3576	T5691	T5689	prep	of,exons
R3577	T5692	T5693	det	the,gene
R3578	T5693	T5691	pobj	gene,of
R3579	T5694	T5665	punct	.,comprises
R358	T748	T746	pobj	families,between
R3580	T5696	T5697	prep	In,encoded
R3581	T5698	T5699	det	the,organisms
R3582	T5699	T5696	pobj	organisms,In
R3583	T5700	T5699	amod	higher,organisms
R3584	T5701	T5699	punct	", ",organisms
R3585	T5702	T5703	compound	D.,melanogaster
R3586	T5703	T5699	appos	melanogaster,organisms
R3587	T5704	T5703	punct	", ",melanogaster
R3588	T5705	T5703	cc	and,melanogaster
R3589	T5706	T5707	det	the,intestinalis
R359	T749	T733	punct	", ",evolved
R3590	T5707	T5703	conj	intestinalis,melanogaster
R3591	T5708	T5709	compound	deuterostomes,C.
R3592	T5709	T5707	compound	C.,intestinalis
R3593	T5710	T5707	prep	to,intestinalis
R3594	T5711	T5710	pobj	human,to
R3595	T5712	T5697	punct	", ",encoded
R3596	T5713	T5714	det	this,feature
R3597	T5714	T5697	nsubjpass	feature,encoded
R3598	T5715	T5697	auxpass	is,encoded
R3599	T5716	T5697	advmod	also,encoded
R360	T750	T733	nsubj	genes,evolved
R3600	T5717	T5697	agent	by,encoded
R3601	T5718	T5719	det	the,exons
R3602	T5719	T5717	pobj	exons,by
R3603	T5720	T5719	amod	final,exons
R3604	T5721	T5719	prep	of,exons
R3605	T5722	T5723	det	the,gene
R3606	T5723	T5721	pobj	gene,of
R3607	T5724	T5725	punct	(,five
R3608	T5725	T5697	parataxis	five,encoded
R3609	T5726	T5725	prep	in,five
R361	T751	T733	aux	have,evolved
R3610	T5727	T5728	compound	D.,melanogaster
R3611	T5728	T5726	pobj	melanogaster,in
R3612	T5729	T5725	punct	", ",five
R3613	T5730	T5725	appos	seven,five
R3614	T5731	T5730	prep	in,seven
R3615	T5732	T5733	det	the,genes
R3616	T5733	T5731	pobj	genes,in
R3617	T5734	T5733	compound	deuterostome,genes
R3618	T5735	T5725	punct	),five
R3619	T5736	T5697	punct	.,encoded
R362	T752	T753	preconj	both,discrete
R3620	T5738	T5739	prep	Outside,show
R3621	T5740	T5738	prep	of,Outside
R3622	T5741	T5742	det	the,domain
R3623	T5742	T5740	pobj	domain,of
R3624	T5743	T5742	compound	TACC,domain
R3625	T5744	T5739	punct	", ",show
R3626	T5745	T5739	advmod	however,show
R3627	T5746	T5739	punct	", ",show
R3628	T5747	T5748	compound	TACC,members
R3629	T5748	T5739	nsubj	members,show
R363	T753	T754	amod	discrete,functions
R3630	T5749	T5748	compound	family,members
R3631	T5750	T5751	advmod	relatively,little
R3632	T5751	T5752	amod	little,homology
R3633	T5752	T5739	dobj	homology,show
R3634	T5753	T5739	punct	.,show
R3635	T5755	T5756	nsubj	It,is
R3636	T5757	T5756	acomp	interesting,is
R3637	T5758	T5759	mark	that,contains
R3638	T5759	T5756	ccomp	contains,is
R3639	T5760	T5761	det	each,gene
R364	T754	T733	dobj	functions,evolved
R3640	T5761	T5759	nsubj	gene,contains
R3641	T5762	T5761	compound	TACC,gene
R3642	T5763	T5764	nummod	one,exon
R3643	T5764	T5759	dobj	exon,contains
R3644	T5765	T5764	amod	large,exon
R3645	T5766	T5764	punct	", ",exon
R3646	T5767	T5768	dep	which,shows
R3647	T5768	T5764	relcl	shows,exon
R3648	T5769	T5770	amod	considerable,variability
R3649	T5770	T5768	dobj	variability,shows
R365	T755	T753	punct	", ",discrete
R3650	T5771	T5768	prep	between,shows
R3651	T5772	T5773	compound	TACC,orthologues
R3652	T5773	T5771	pobj	orthologues,between
R3653	T5774	T5768	punct	", ",shows
R3654	T5775	T5768	cc	and,shows
R3655	T5776	T5768	conj	constitutes,shows
R3656	T5777	T5778	det	the,difference
R3657	T5778	T5776	dobj	difference,constitutes
R3658	T5779	T5778	amod	main,difference
R3659	T5780	T5778	prep	between,difference
R366	T756	T753	cc	and,discrete
R3660	T5781	T5782	det	the,genes
R3661	T5782	T5780	pobj	genes,between
R3662	T5783	T5782	compound	TACC3,genes
R3663	T5784	T5776	prep	in,constitutes
R3664	T5785	T5786	det	the,vertebrates
R3665	T5786	T5784	pobj	vertebrates,in
R3666	T5787	T5788	punct	(,see
R3667	T5788	T5759	parataxis	see,contains
R3668	T5789	T5788	advmod	below,see
R3669	T5790	T5788	punct	),see
R367	T757	T758	advmod	partially,redundant
R3670	T5791	T5756	punct	.,is
R3671	T5793	T5794	prep	In,contains
R3672	T5795	T5793	pobj	deuterostomes,In
R3673	T5796	T5794	punct	", ",contains
R3674	T5797	T5798	det	this,exon
R3675	T5798	T5794	nsubj	exon,contains
R3676	T5799	T5800	det	the,repeat
R3677	T5800	T5794	dobj	repeat,contains
R3678	T5801	T5800	compound	SDP,repeat
R3679	T5802	T5800	punct	(,repeat
R368	T758	T753	conj	redundant,discrete
R3680	T5803	T5800	cc	or,repeat
R3681	T5804	T5805	prep	in,repeat
R3682	T5805	T5800	conj	repeat,repeat
R3683	T5806	T5807	det	the,case
R3684	T5807	T5804	pobj	case,in
R3685	T5808	T5807	prep	of,case
R3686	T5809	T5810	det	the,TACC3
R3687	T5810	T5808	pobj	TACC3,of
R3688	T5811	T5810	amod	murine,TACC3
R3689	T5812	T5810	case	's,TACC3
R369	T759	T754	prep	with,functions
R3690	T5813	T5805	punct	", ",repeat
R3691	T5814	T5805	det	a,repeat
R3692	T5815	T5816	npadvmod	rodent,specific
R3693	T5816	T5805	amod	specific,repeat
R3694	T5817	T5816	punct	-,specific
R3695	T5818	T5819	nummod	24,acid
R3696	T5819	T5805	compound	acid,repeat
R3697	T5820	T5819	compound	amino,acid
R3698	T5821	T5800	punct	),repeat
R3699	T5822	T5800	punct	", ",repeat
R370	T760	T761	poss	their,members
R3700	T5823	T5824	dep	which,is
R3701	T5824	T5800	relcl	is,repeat
R3702	T5825	T5824	acomp	responsible,is
R3703	T5826	T5825	prep	for,responsible
R3704	T5827	T5828	det	the,binding
R3705	T5828	T5826	pobj	binding,for
R3706	T5829	T5828	prep	of,binding
R3707	T5830	T5831	det	the,component
R3708	T5831	T5829	pobj	component,of
R3709	T5832	T5833	nmod	SWI,SNF
R371	T761	T759	pobj	members,with
R3710	T5833	T5831	nmod	SNF,component
R3711	T5834	T5833	punct	/,SNF
R3712	T5835	T5836	compound	chromatin,remodeling
R3713	T5836	T5833	appos	remodeling,SNF
R3714	T5837	T5833	amod	complex,SNF
R3715	T5838	T5831	appos	GAS41,component
R3716	T5839	T5840	punct	[,16
R3717	T5840	T5824	parataxis	16,is
R3718	T5841	T5840	nummod	15,16
R3719	T5842	T5840	punct	",",16
R372	T762	T761	amod	related,members
R3720	T5843	T5840	punct	],16
R3721	T5844	T5794	punct	.,contains
R3722	T5846	T5847	prep	Of,show
R3723	T5848	T5849	det	the,proteins
R3724	T5849	T5846	pobj	proteins,Of
R3725	T5850	T5849	compound	vertebrate,proteins
R3726	T5851	T5849	compound	TACC,proteins
R3727	T5852	T5847	punct	", ",show
R3728	T5853	T5854	det	the,orthologues
R3729	T5854	T5847	nsubj	orthologues,show
R373	T763	T761	compound	family,members
R3730	T5855	T5854	compound	TACC3,orthologues
R3731	T5856	T5857	det	the,variability
R3732	T5857	T5847	dobj	variability,show
R3733	T5858	T5857	amod	greatest,variability
R3734	T5859	T5857	prep	in,variability
R3735	T5860	T5859	pobj	size,in
R3736	T5861	T5860	cc	and,size
R3737	T5862	T5860	conj	sequence,size
R3738	T5863	T5847	punct	", ",show
R3739	T5864	T5847	advcl	ranging,show
R374	T764	T733	punct	.,evolved
R3740	T5865	T5864	prep	in,ranging
R3741	T5866	T5865	pobj	size,in
R3742	T5867	T5864	prep	from,ranging
R3743	T5868	T5869	nummod	599,acids
R3744	T5869	T5867	pobj	acids,from
R3745	T5870	T5869	compound	amino,acids
R3746	T5871	T5869	prep	for,acids
R3747	T5872	T5873	det	the,protein
R3748	T5873	T5871	pobj	protein,for
R3749	T5874	T5873	compound	rat,protein
R375	T766	T767	prep	With,are
R3750	T5875	T5873	compound	TACC3,protein
R3751	T5876	T5867	punct	", ",from
R3752	T5877	T5867	prep	to,from
R3753	T5878	T5879	nummod	942,acids
R3754	T5879	T5877	pobj	acids,to
R3755	T5880	T5879	compound	amino,acids
R3756	T5881	T5879	prep	in,acids
R3757	T5882	T5883	det	the,protein
R3758	T5883	T5881	pobj	protein,in
R3759	T5884	T5883	compound	Danio,protein
R376	T768	T769	det	the,completion
R3760	T5885	T5883	compound	rerio,protein
R3761	T5886	T5847	punct	.,show
R3762	T5888	T5889	det	The,reasons
R3763	T5889	T5890	nsubj	reasons,are
R3764	T5891	T5889	prep	for,reasons
R3765	T5892	T5893	det	these,differences
R3766	T5893	T5891	pobj	differences,for
R3767	T5894	T5890	acomp	apparent,are
R3768	T5895	T5890	prep	from,are
R3769	T5896	T5897	det	the,structure
R377	T769	T766	pobj	completion,With
R3770	T5897	T5895	pobj	structure,from
R3771	T5898	T5897	amod	genomic,structure
R3772	T5899	T5897	prep	of,structure
R3773	T5900	T5901	det	the,orthologues
R3774	T5901	T5899	pobj	orthologues,of
R3775	T5902	T5901	compound	TACC3,orthologues
R3776	T5903	T5890	punct	.,are
R3777	T5905	T5906	nsubjpass	TACC3,divided
R3778	T5907	T5906	aux	can,divided
R3779	T5908	T5906	auxpass	be,divided
R378	T770	T769	prep	of,completion
R3780	T5909	T5906	prep	into,divided
R3781	T5910	T5911	nummod	three,sections
R3782	T5911	T5909	pobj	sections,into
R3783	T5912	T5911	punct	: ,sections
R3784	T5913	T5914	det	a,region
R3785	T5914	T5911	appos	region,sections
R3786	T5915	T5914	amod	conserved,region
R3787	T5916	T5917	npadvmod	N,terminal
R3788	T5917	T5914	amod	terminal,region
R3789	T5918	T5917	punct	-,terminal
R379	T771	T772	det	the,projects
R3790	T5919	T5914	punct	(,region
R3791	T5920	T5914	appos	CNTR,region
R3792	T5921	T5914	punct	),region
R3793	T5922	T5914	prep	of,region
R3794	T5923	T5924	nummod	108,acids
R3795	T5924	T5922	pobj	acids,of
R3796	T5925	T5924	compound	amino,acids
R3797	T5926	T5924	punct	", ",acids
R3798	T5927	T5924	acl	encoded,acids
R3799	T5928	T5927	agent	by,encoded
R380	T772	T770	pobj	projects,of
R3800	T5929	T5930	nmod	exons,2
R3801	T5930	T5928	pobj	2,by
R3802	T5931	T5930	cc	and,2
R3803	T5932	T5930	conj	3,2
R3804	T5933	T5927	prep	in,encoded
R3805	T5934	T5935	det	each,gene
R3806	T5935	T5933	pobj	gene,in
R3807	T5936	T5935	compound	vertebrate,gene
R3808	T5937	T5935	compound	TACC3,gene
R3809	T5938	T5914	punct	", ",region
R381	T773	T774	compound	genome,sequencing
R3810	T5939	T5940	det	the,domain
R3811	T5940	T5914	conj	domain,region
R3812	T5941	T5940	amod	conserved,domain
R3813	T5942	T5940	compound	TACC,domain
R3814	T5943	T5940	acl	distributed,domain
R3815	T5944	T5943	prep	over,distributed
R3816	T5945	T5946	det	the,exons
R3817	T5946	T5944	pobj	exons,over
R3818	T5947	T5946	amod	final,exons
R3819	T5948	T5946	nummod	seven,exons
R382	T774	T772	compound	sequencing,projects
R3820	T5949	T5940	punct	", ",domain
R3821	T5950	T5940	cc	and,domain
R3822	T5951	T5952	det	a,region
R3823	T5952	T5940	conj	region,domain
R3824	T5953	T5954	advmod	highly,variable
R3825	T5954	T5952	amod	variable,region
R3826	T5955	T5952	amod	central,region
R3827	T5956	T5906	punct	.,divided
R3828	T5958	T5959	det	The,lack
R3829	T5959	T5960	nsubjpass	lack,noted
R383	T775	T772	prep	of,projects
R3830	T5961	T5959	prep	of,lack
R3831	T5962	T5961	pobj	conservation,of
R3832	T5963	T5962	prep	in,conservation
R3833	T5964	T5965	preconj	both,size
R3834	T5965	T5963	pobj	size,in
R3835	T5966	T5965	cc	and,size
R3836	T5967	T5965	conj	sequence,size
R3837	T5968	T5965	prep	of,size
R3838	T5969	T5970	det	the,portion
R3839	T5970	T5968	pobj	portion,of
R384	T776	T775	pobj	human,of
R3840	T5971	T5970	amod	central,portion
R3841	T5972	T5970	prep	of,portion
R3842	T5973	T5974	det	the,proteins
R3843	T5974	T5972	pobj	proteins,of
R3844	T5975	T5974	compound	TACC3,proteins
R3845	T5976	T5974	prep	of,proteins
R3846	T5977	T5978	amod	human,mouse
R3847	T5978	T5976	pobj	mouse,of
R3848	T5979	T5978	cc	and,mouse
R3849	T5980	T5960	aux	has,noted
R385	T777	T776	punct	", ",human
R3850	T5981	T5960	auxpass	been,noted
R3851	T5982	T5960	advmod	previously,noted
R3852	T5983	T5960	punct	", ",noted
R3853	T5984	T5960	cc	and,noted
R3854	T5985	T5960	conj	accounts,noted
R3855	T5986	T5985	prep	for,accounts
R3856	T5987	T5988	det	the,difference
R3857	T5988	T5986	pobj	difference,for
R3858	T5989	T5988	amod	major,difference
R3859	T5990	T5988	prep	between,difference
R386	T778	T776	conj	mouse,human
R3860	T5991	T5992	det	these,orthologues
R3861	T5992	T5990	pobj	orthologues,between
R3862	T5993	T5992	nummod	two,orthologues
R3863	T5994	T5995	punct	[,2
R3864	T5995	T5985	parataxis	2,accounts
R3865	T5996	T5995	punct	],2
R3866	T5997	T5960	punct	.,noted
R3867	T5999	T6000	det	The,majority
R3868	T6000	T6001	nsubjpass	majority,encoded
R3869	T6002	T6000	prep	of,majority
R387	T779	T778	punct	", ",mouse
R3870	T6003	T6004	det	this,portion
R3871	T6004	T6002	pobj	portion,of
R3872	T6005	T6004	amod	central,portion
R3873	T6006	T6004	punct	", ",portion
R3874	T6007	T6008	dep	which,contains
R3875	T6008	T6004	relcl	contains,portion
R3876	T6009	T6010	det	the,motifs
R3877	T6010	T6008	dobj	motifs,contains
R3878	T6011	T6010	compound	SDP,motifs
R3879	T6012	T6010	compound	repeat,motifs
R388	T780	T778	conj	rat,mouse
R3880	T6013	T6001	punct	", ",encoded
R3881	T6014	T6001	auxpass	is,encoded
R3882	T6015	T6001	agent	by,encoded
R3883	T6016	T6017	nummod	one,exon
R3884	T6017	T6015	pobj	exon,by
R3885	T6018	T6001	prep	in,encoded
R3886	T6019	T6018	pobj	human,in
R3887	T6020	T6019	cc	and,human
R3888	T6021	T6022	det	the,pufferfish
R3889	T6022	T6019	conj	pufferfish,human
R389	T781	T780	punct	", ",rat
R3890	T6023	T6024	punct	(,emb\|CAAB01001184
R3891	T6024	T6001	parataxis	emb\|CAAB01001184,encoded
R3892	T6025	T6024	punct	),emb\|CAAB01001184
R3893	T6026	T6001	punct	.,encoded
R3894	T6028	T6029	prep	In,composed
R3895	T6030	T6028	pobj	rodents,In
R3896	T6031	T6029	punct	", ",composed
R3897	T6032	T6029	advmod	however,composed
R3898	T6033	T6029	punct	", ",composed
R3899	T6034	T6035	det	this,region
R390	T782	T783	compound	fruit,fly
R3900	T6035	T6029	nsubjpass	region,composed
R3901	T6036	T6029	auxpass	is,composed
R3902	T6037	T6038	advmod	almost,entirely
R3903	T6038	T6029	advmod	entirely,composed
R3904	T6039	T6029	prep	of,composed
R3905	T6040	T6041	nummod	seven,repeats
R3906	T6041	T6039	pobj	repeats,of
R3907	T6042	T6043	nummod	24,acid
R3908	T6043	T6041	compound	acid,repeats
R3909	T6044	T6043	compound	amino,acid
R391	T783	T780	conj	fly,rat
R3910	T6045	T6041	punct	", ",repeats
R3911	T6046	T6047	dep	which,located
R3912	T6047	T6041	relcl	located,repeats
R3913	T6048	T6047	auxpass	are,located
R3914	T6049	T6047	prep	in,located
R3915	T6050	T6051	det	a,exon
R3916	T6051	T6049	pobj	exon,in
R3917	T6052	T6051	amod	single,exon
R3918	T6053	T6051	prep	of,exon
R3919	T6054	T6055	det	the,genes
R392	T784	T783	cc	and,fly
R3920	T6055	T6053	pobj	genes,of
R3921	T6056	T6055	nmod	mouse,genes
R3922	T6057	T6056	cc	and,mouse
R3923	T6058	T6056	conj	rat,mouse
R3924	T6059	T6055	compound	TACC3,genes
R3925	T6060	T6029	punct	.,composed
R3926	T6062	T6063	nsubjpass	It,reported
R3927	T6064	T6063	aux	has,reported
R3928	T6065	T6063	auxpass	been,reported
R3929	T6066	T6063	advmod	previously,reported
R393	T785	T783	conj	nematodes,fly
R3930	T6067	T6068	mark	that,are
R3931	T6068	T6063	ccomp	are,reported
R3932	T6069	T6068	expl	there,are
R3933	T6070	T6071	nummod	four,variants
R3934	T6071	T6068	attr	variants,are
R3935	T6072	T6073	compound	mouse,TACC3
R3936	T6073	T6071	compound	TACC3,variants
R3937	T6074	T6071	compound	splice,variants
R3938	T6075	T6076	dep	that,differ
R3939	T6076	T6071	relcl	differ,variants
R394	T786	T767	punct	", ",are
R3940	T6077	T6076	prep	in,differ
R3941	T6078	T6079	det	the,number
R3942	T6079	T6077	pobj	number,in
R3943	T6080	T6079	prep	of,number
R3944	T6081	T6082	det	these,repeats
R3945	T6082	T6080	pobj	repeats,of
R3946	T6083	T6084	punct	[,17
R3947	T6084	T6063	parataxis	17,reported
R3948	T6085	T6084	nummod	2,17
R3949	T6086	T6084	punct	",",17
R395	T787	T767	nsubj	we,are
R3950	T6087	T6084	nummod	7,17
R3951	T6088	T6084	punct	",",17
R3952	T6089	T6084	punct	],17
R3953	T6090	T6063	punct	.,reported
R3954	T6092	T6093	mark	As,are
R3955	T6093	T6096	advcl	are,appears
R3956	T6094	T6095	det	these,repeats
R3957	T6095	T6093	nsubj	repeats,are
R3958	T6097	T6093	acomp	present,are
R3959	T6098	T6093	prep	in,are
R396	T788	T767	advmod	now,are
R3960	T6099	T6100	det	a,exon
R3961	T6100	T6098	pobj	exon,in
R3962	T6101	T6100	amod	single,exon
R3963	T6102	T6096	punct	", ",appears
R3964	T6103	T6096	nsubj	it,appears
R3965	T6104	T6096	oprd	likely,appears
R3966	T6105	T6106	mark	that,be
R3967	T6106	T6096	ccomp	be,appears
R3968	T6107	T6108	det	these,sequences
R3969	T6108	T6106	nsubj	sequences,be
R397	T789	T767	prep	in,are
R3970	T6109	T6108	amod	different,sequences
R3971	T6110	T6106	aux	may,be
R3972	T6111	T6112	det	the,result
R3973	T6112	T6106	attr	result,be
R3974	T6113	T6112	prep	of,result
R3975	T6114	T6115	det	the,polymerases
R3976	T6115	T6113	pobj	polymerases,of
R3977	T6116	T6115	compound	DNA,polymerases
R3978	T6117	T6115	acl	used,polymerases
R3979	T6118	T6117	prep	in,used
R398	T790	T791	det	a,position
R3980	T6119	T6120	det	the,synthesis
R3981	T6120	T6118	pobj	synthesis,in
R3982	T6121	T6120	compound	cDNA,synthesis
R3983	T6122	T6115	cc	and,polymerases
R3984	T6123	T6122	punct	/,and
R3985	T6124	T6122	cc	or,and
R3986	T6125	T6126	compound	PCR,reaction
R3987	T6126	T6127	nsubj	reaction,stuttering
R3988	T6127	T6115	conj	stuttering,polymerases
R3989	T6128	T6127	prep	through,stuttering
R399	T791	T789	pobj	position,in
R3990	T6129	T6130	det	the,motif
R3991	T6130	T6128	pobj	motif,through
R3992	T6131	T6130	compound	repeat,motif
R3993	T6132	T6096	punct	.,appears
R3994	T6134	T6135	det	The,sequence
R3995	T6135	T6137	nsubj	sequence,is
R3996	T6136	T6135	amod	correct,sequence
R3997	T6138	T6135	punct	", ",sequence
R3998	T6139	T6135	acl	reported,sequence
R3999	T6140	T6139	agent	by,reported
R400	T792	T793	aux	to,ask
R4000	T6141	T6140	pobj	Sadek,by
R4001	T6142	T6143	advmod	et,al
R4002	T6143	T6141	advmod	al,Sadek
R4003	T6144	T6145	punct	[,7
R4004	T6145	T6139	parataxis	7,reported
R4005	T6146	T6145	punct	],7
R4006	T6147	T6137	punct	", ",is
R4007	T6148	T6149	det	the,one
R4008	T6149	T6137	attr	one,is
R4009	T6150	T6149	acl	used,one
R401	T793	T791	acl	ask,position
R4010	T6151	T6150	prep	throughout,used
R4011	T6152	T6153	det	the,entirety
R4012	T6153	T6151	pobj	entirety,throughout
R4013	T6154	T6153	prep	of,entirety
R4014	T6155	T6156	det	this,manuscript
R4015	T6156	T6154	pobj	manuscript,of
R4016	T6157	T6137	punct	.,is
R4017	T6159	T6160	det	These,repeats
R4018	T6160	T6161	nsubj	repeats,are
R4019	T6162	T6161	neg	not,are
R402	T794	T795	amod	fundamental,questions
R4020	T6163	T6161	acomp	evident,are
R4021	T6164	T6161	prep	in,are
R4022	T6165	T6166	det	the,protein
R4023	T6166	T6164	pobj	protein,in
R4024	T6167	T6166	compound	rabbit,protein
R4025	T6168	T6166	punct	", ",protein
R4026	T6169	T6166	cc	or,protein
R4027	T6170	T6171	det	any,protein
R4028	T6171	T6166	conj	protein,protein
R4029	T6172	T6171	amod	other,protein
R403	T795	T793	dobj	questions,ask
R4030	T6173	T6171	compound	TACC,protein
R4031	T6174	T6161	punct	", ",are
R4032	T6175	T6161	cc	and,are
R4033	T6176	T6177	aux	may,indicate
R4034	T6177	T6161	conj	indicate,are
R4035	T6178	T6179	mark	that,evolved
R4036	T6179	T6177	ccomp	evolved,indicate
R4037	T6180	T6181	det	the,TACC3
R4038	T6181	T6179	nsubj	TACC3,evolved
R4039	T6182	T6181	compound	rodent,TACC3
R404	T796	T793	prep	in,ask
R4040	T6183	T6179	aux	has,evolved
R4041	T6184	T6185	amod	distinct,functions
R4042	T6185	T6179	dobj	functions,evolved
R4043	T6186	T6177	punct	", ",indicate
R4044	T6187	T6188	mark	as,noted
R4045	T6188	T6177	advcl	noted,indicate
R4046	T6189	T6188	aux	has,noted
R4047	T6190	T6188	advmod	already,noted
R4048	T6191	T6188	auxpass	been,noted
R4049	T6192	T6188	prep	for,noted
R405	T797	T796	pobj	regard,in
R4050	T6193	T6194	det	the,TACC3
R4051	T6194	T6192	pobj	TACC3,for
R4052	T6195	T6194	amod	amphibian,TACC3
R4053	T6196	T6194	compound	Xenopus,TACC3
R4054	T6197	T6194	punct	", ",TACC3
R4055	T6198	T6194	appos	maskin,TACC3
R4056	T6199	T6200	punct	[,8
R4057	T6200	T6188	parataxis	8,noted
R4058	T6201	T6200	punct	],8
R4059	T6202	T6161	punct	.,are
R406	T798	T797	prep	to,regard
R4064	T6381	T6382	amod	Alternative,splicing
R4065	T6383	T6382	prep	in,splicing
R4066	T6384	T6385	compound	vertebrate,genes
R4067	T6385	T6383	pobj	genes,in
R4068	T6386	T6385	compound	TACC,genes
R4069	T6388	T6389	mark	Whereas,drive
R407	T799	T800	advmod	how,interact
R4070	T6389	T6393	advcl	drive,give
R4071	T6390	T6391	compound	exon,shuffling
R4072	T6391	T6389	nsubj	shuffling,drive
R4073	T6392	T6389	aux	can,drive
R4074	T6394	T6395	det	the,diversification
R4075	T6395	T6389	dobj	diversification,drive
R4076	T6396	T6395	amod	functional,diversification
R4077	T6397	T6395	prep	of,diversification
R4078	T6398	T6399	compound	gene,families
R4079	T6399	T6397	pobj	families,of
R408	T800	T798	pcomp	interact,to
R4080	T6400	T6389	prep	over,drive
R4081	T6401	T6402	amod	evolutionary,time
R4082	T6402	T6400	pobj	time,over
R4083	T6403	T6393	punct	", ",give
R4084	T6404	T6405	det	the,splicing
R4085	T6405	T6393	nsubj	splicing,give
R4086	T6406	T6405	amod	temporal,splicing
R4087	T6407	T6406	cc	and,temporal
R4088	T6408	T6407	punct	/,and
R4089	T6409	T6407	cc	or,and
R409	T801	T800	nsubj	genes,interact
R4090	T6410	T6411	npadvmod	tissue,specific
R4091	T6411	T6406	conj	specific,temporal
R4092	T6412	T6405	amod	alternative,splicing
R4093	T6413	T6405	prep	of,splicing
R4094	T6414	T6415	det	a,gene
R4095	T6415	T6413	pobj	gene,of
R4096	T6416	T6393	aux	can,give
R4097	T6417	T6393	dobj	rise,give
R4098	T6418	T6393	prep	to,give
R4099	T6419	T6420	amod	functional,diversification
R410	T802	T800	prep	in,interact
R4100	T6420	T6418	pobj	diversification,to
R4101	T6421	T6420	prep	of,diversification
R4102	T6422	T6423	det	a,gene
R4103	T6423	T6421	pobj	gene,of
R4104	T6424	T6423	amod	single,gene
R4105	T6425	T6393	prep	during,give
R4106	T6426	T6427	det	the,development
R4107	T6427	T6425	pobj	development,during
R4108	T6428	T6427	prep	of,development
R4109	T6429	T6430	det	an,organism
R411	T803	T804	det	the,context
R4110	T6430	T6428	pobj	organism,of
R4111	T6431	T6393	punct	.,give
R4112	T6433	T6434	mark	Although,documented
R4113	T6434	T6443	advcl	documented,observed
R4114	T6435	T6436	det	no,splicing
R4115	T6436	T6434	nsubjpass	splicing,documented
R4116	T6437	T6436	amod	alternative,splicing
R4117	T6438	T6436	prep	of,splicing
R4118	T6439	T6438	pobj	TACC3,of
R4119	T6440	T6434	aux	has,documented
R412	T804	T802	pobj	context,in
R4120	T6441	T6434	auxpass	been,documented
R4121	T6442	T6434	advmod	clearly,documented
R4122	T6444	T6443	punct	", ",observed
R4123	T6445	T6446	preconj	both,temporal
R4124	T6446	T6447	amod	temporal,splicing
R4125	T6447	T6443	nsubjpass	splicing,observed
R4126	T6448	T6446	cc	and,temporal
R4127	T6449	T6450	npadvmod	tissue,specific
R4128	T6450	T6446	conj	specific,temporal
R4129	T6451	T6443	auxpass	is,observed
R413	T805	T804	prep	of,context
R4130	T6452	T6443	prep	in,observed
R4131	T6453	T6454	det	the,genes
R4132	T6454	T6452	pobj	genes,in
R4133	T6455	T6454	nmod	TACC1,genes
R4134	T6456	T6455	cc	and,TACC1
R4135	T6457	T6455	conj	TACC2,TACC1
R4136	T6458	T6443	punct	.,observed
R4137	T6460	T6461	prep	In,accounts
R4138	T6462	T6463	det	the,case
R4139	T6463	T6460	pobj	case,In
R414	T806	T807	det	the,organism
R4140	T6464	T6463	prep	of,case
R4141	T6465	T6464	pobj	TACC2,of
R4142	T6466	T6461	punct	", ",accounts
R4143	T6467	T6468	det	an,exon
R4144	T6468	T6461	nsubj	exon,accounts
R4145	T6469	T6468	amod	additional,exon
R4146	T6470	T6468	amod	large,exon
R4147	T6471	T6472	punct	(,kb
R4148	T6472	T6470	parataxis	kb,large
R4149	T6473	T6472	nummod	5,kb
R415	T807	T805	pobj	organism,of
R4150	T6474	T6472	punct	),kb
R4151	T6475	T6461	prep	for,accounts
R4152	T6476	T6477	det	the,difference
R4153	T6477	T6475	pobj	difference,for
R4154	T6478	T6477	amod	main,difference
R4155	T6479	T6477	prep	between,difference
R4156	T6480	T6481	det	the,variants
R4157	T6481	T6479	pobj	variants,between
R4158	T6482	T6481	amod	major,variants
R4159	T6483	T6481	compound	splice,variants
R416	T808	T807	amod	whole,organism
R4160	T6484	T6481	prep	of,variants
R4161	T6485	T6486	det	the,genes
R4162	T6486	T6484	pobj	genes,of
R4163	T6487	T6486	compound	vertebrate,genes
R4164	T6488	T6486	compound	TACC2,genes
R4165	T6489	T6490	punct	[,3
R4166	T6490	T6461	parataxis	3,accounts
R4167	T6491	T6490	punct	],3
R4168	T6492	T6461	punct	.,accounts
R4169	T6494	T6495	det	The,splicing
R417	T809	T767	punct	.,are
R4170	T6495	T6497	nsubj	splicing,suggests
R4171	T6496	T6495	amod	alternative,splicing
R4172	T6498	T6495	prep	of,splicing
R4173	T6499	T6500	det	this,exon
R4174	T6500	T6498	pobj	exon,of
R4175	T6501	T6502	det	a,difference
R4176	T6502	T6497	dobj	difference,suggests
R4177	T6503	T6502	amod	major,difference
R4178	T6504	T6502	amod	functional,difference
R4179	T6505	T6502	prep	between,difference
R418	T811	T812	advmod	Thus,is
R4180	T6506	T6507	det	the,isoforms
R4181	T6507	T6505	pobj	isoforms,between
R4182	T6508	T6507	nummod	two,isoforms
R4183	T6509	T6507	compound	TACC2,isoforms
R4184	T6510	T6507	punct	", ",isoforms
R4185	T6511	T6507	appos	TACC2s,isoforms
R4186	T6512	T6511	cc	and,TACC2s
R4187	T6513	T6511	conj	TACC2l,TACC2s
R4188	T6514	T6515	punct	[,3
R4189	T6515	T6502	parataxis	3,difference
R419	T813	T812	punct	", ",is
R4190	T6516	T6515	punct	],3
R4191	T6517	T6502	punct	", ",difference
R4192	T6518	T6519	advmod	as,as
R4193	T6519	T6502	cc	as,difference
R4194	T6520	T6519	advmod	well,as
R4195	T6521	T6522	det	a,difference
R4196	T6522	T6502	conj	difference,difference
R4197	T6523	T6522	amod	significant,difference
R4198	T6524	T6522	prep	between,difference
R4199	T6525	T6524	pobj	TACC2,between
R420	T814	T812	prep	with,is
R4200	T6526	T6525	cc	and,TACC2
R4201	T6527	T6528	poss	its,relative
R4202	T6528	T6525	conj	relative,TACC2
R4203	T6529	T6528	amod	closest,relative
R4204	T6530	T6531	compound	TACC,family
R4205	T6531	T6528	compound	family,relative
R4206	T6532	T6528	punct	", ",relative
R4207	T6533	T6528	appos	TACC1,relative
R4208	T6534	T6497	punct	.,suggests
R4209	T6536	T6537	advmod	However,is
R421	T815	T816	det	the,application
R4210	T6538	T6537	punct	", ",is
R4211	T6539	T6540	det	the,function
R4212	T6540	T6537	nsubj	function,is
R4213	T6541	T6540	prep	of,function
R4214	T6542	T6543	det	this,region
R4215	T6543	T6541	pobj	region,of
R4216	T6544	T6543	prep	of,region
R4217	T6545	T6546	det	the,isoform
R4218	T6546	T6544	pobj	isoform,of
R4219	T6547	T6546	compound	TACC2l,isoform
R422	T816	T814	pobj	application,with
R4220	T6548	T6537	advmod	current,is
R4221	T6549	T6537	acomp	unknown,is
R4222	T6550	T6537	punct	.,is
R4223	T6552	T6553	amod	Alternative,splicing
R4224	T6553	T6554	nsubjpass	splicing,noted
R4225	T6555	T6553	punct	", ",splicing
R4226	T6556	T6553	advmod	together,splicing
R4227	T6557	T6556	prep	with,together
R4228	T6558	T6559	amod	differential,usage
R4229	T6559	T6557	pobj	usage,with
R423	T817	T816	amod	appropriate,application
R4230	T6560	T6559	compound	promoter,usage
R4231	T6561	T6554	aux	has,noted
R4232	T6562	T6554	advmod	already,noted
R4233	T6563	T6554	auxpass	been,noted
R4234	T6564	T6554	prep	for,noted
R4235	T6565	T6566	det	the,gene
R4236	T6566	T6564	pobj	gene,for
R4237	T6567	T6566	amod	human,gene
R4238	T6568	T6566	compound	TACC1,gene
R4239	T6569	T6570	punct	[,19
R424	T818	T816	prep	of,application
R4240	T6570	T6554	parataxis	19,noted
R4241	T6571	T6570	nummod	18,19
R4242	T6572	T6570	punct	",",19
R4243	T6573	T6570	punct	],19
R4244	T6574	T6554	punct	.,noted
R4245	T6576	T6577	prep	In,identified
R4246	T6578	T6576	pobj	addition,In
R4247	T6579	T6577	punct	", ",identified
R4248	T6580	T6581	mark	as,shown
R4249	T6581	T6577	advcl	shown,identified
R425	T819	T818	pobj	bioinformatics,of
R4250	T6582	T6581	prep	in,shown
R4251	T6583	T6582	pobj	Fig.,in
R4252	T6584	T6583	nummod	5,Fig.
R4253	T6585	T6577	punct	", ",identified
R4254	T6586	T6577	nsubj	we,identified
R4255	T6587	T6577	aux	have,identified
R4256	T6588	T6589	amod	additional,isoforms
R4257	T6589	T6577	dobj	isoforms,identified
R4258	T6590	T6589	compound	TACC1,isoforms
R4259	T6591	T6592	dep	that,result
R426	T820	T812	punct	", ",is
R4260	T6592	T6589	relcl	result,isoforms
R4261	T6593	T6592	prep	from,result
R4262	T6594	T6595	amod	alternative,splicing
R4263	T6595	T6593	pobj	splicing,from
R4264	T6596	T6595	prep	of,splicing
R4265	T6597	T6598	nmod	exons,4a
R4266	T6598	T6596	pobj	4a,of
R4267	T6599	T6598	nummod	1b,4a
R4268	T6600	T6598	punct	-,4a
R4269	T6601	T6577	punct	.,identified
R427	T821	T812	nsubj	it,is
R4270	T6603	T6604	det	The,functions
R4271	T6604	T6605	nsubj	functions,are
R4272	T6605	T6610	ccomp	are,include
R4273	T6606	T6604	prep	of,functions
R4274	T6607	T6608	det	these,isoforms
R4275	T6608	T6606	pobj	isoforms,of
R4276	T6609	T6608	amod	different,isoforms
R4277	T6611	T6605	acomp	unknown,are
R4278	T6612	T6610	punct	", ",include
R4279	T6613	T6610	advmod	however,include
R428	T822	T812	advmod	now,is
R4280	T6614	T6615	det	the,region
R4281	T6615	T6610	nsubj	region,include
R4282	T6616	T6615	acl	deleted,region
R4283	T6617	T6616	prep	from,deleted
R4284	T6618	T6619	det	the,variants
R4285	T6619	T6617	pobj	variants,from
R4286	T6620	T6619	amod	shorter,variants
R4287	T6621	T6610	aux	can,include
R4288	T6622	T6623	det	the,site
R4289	T6623	T6610	dobj	site,include
R429	T823	T812	acomp	possible,is
R4290	T6624	T6623	compound	binding,site
R4291	T6625	T6623	prep	for,site
R4292	T6626	T6625	pobj	LSm7,for
R4293	T6627	T6628	punct	[,20
R4294	T6628	T6623	parataxis	20,site
R4295	T6629	T6628	punct	],20
R4296	T6630	T6631	punct	(,C
R4297	T6631	T6623	parataxis	C,site
R4298	T6632	T6631	compound	variants,C
R4299	T6633	T6631	punct	", ",C
R430	T824	T825	aux	to,trace
R4300	T6634	T6631	appos	D,C
R4301	T6635	T6631	punct	", ",C
R4302	T6636	T6631	appos	F,C
R4303	T6637	T6638	punct	-,I
R4304	T6638	T6636	prep	I,F
R4305	T6639	T6631	punct	),C
R4306	T6640	T6623	punct	", ",site
R4307	T6641	T6623	cc	and,site
R4308	T6642	T6641	punct	/,and
R4309	T6643	T6641	cc	or,and
R431	T825	T812	xcomp	trace,is
R4310	T6644	T6645	det	the,signals
R4311	T6645	T6623	conj	signals,site
R4312	T6646	T6645	amod	nuclear,signals
R4313	T6647	T6645	compound	localization,signals
R4314	T6648	T6645	cc	and,signals
R4315	T6649	T6650	compound	binding,site
R4316	T6650	T6645	conj	site,signals
R4317	T6651	T6650	prep	for,site
R4318	T6652	T6651	pobj	GAS41,for
R4319	T6653	T6654	punct	[,15
R432	T826	T827	det	the,lineage
R4320	T6654	T6650	parataxis	15,site
R4321	T6655	T6654	punct	],15
R4322	T6656	T6645	cc	and,signals
R4323	T6657	T6645	conj	PCTAIRE2BP,signals
R4324	T6658	T6659	punct	[,20
R4325	T6659	T6657	parataxis	20,PCTAIRE2BP
R4326	T6660	T6659	punct	],20
R4327	T6661	T6662	punct	(,B
R4328	T6662	T6657	parataxis	B,PCTAIRE2BP
R4329	T6663	T6662	compound	isoforms,B
R433	T827	T825	dobj	lineage,trace
R4330	T6664	T6665	punct	-,D
R4331	T6665	T6662	prep	D,B
R4332	T6666	T6662	punct	", ",B
R4333	T6667	T6662	appos	S,B
R4334	T6668	T6662	punct	),B
R4335	T6669	T6610	punct	.,include
R4336	T6671	T6672	nsubjpass	One,localized
R4337	T6673	T6671	prep	of,One
R4338	T6674	T6675	det	these,isoforms
R4339	T6675	T6673	pobj	isoforms,of
R434	T828	T827	prep	of,lineage
R4340	T6676	T6671	punct	", ",One
R4341	T6677	T6671	appos	TACC1S,One
R4342	T6678	T6672	auxpass	is,localized
R4343	T6679	T6680	advmod	exclusively,to
R4344	T6680	T6672	prep	to,localized
R4345	T6681	T6682	det	the,cytoplasm
R4346	T6682	T6680	pobj	cytoplasm,to
R4347	T6683	T6684	punct	[,19
R4348	T6684	T6672	parataxis	19,localized
R4349	T6685	T6684	punct	],19
R435	T829	T830	amod	particular,genes
R4350	T6686	T6672	punct	", ",localized
R4351	T6687	T6672	advcl	suggesting,localized
R4352	T6688	T6689	mark	that,be
R4353	T6689	T6687	ccomp	be,suggesting
R4354	T6690	T6691	det	the,isoforms
R4355	T6691	T6689	nsubj	isoforms,be
R4356	T6692	T6691	amod	shorter,isoforms
R4357	T6693	T6689	aux	would,be
R4358	T6694	T6689	neg	not,be
R4359	T6695	T6689	acomp	able,be
R436	T830	T828	pobj	genes,of
R4360	T6696	T6697	aux	to,interact
R4361	T6697	T6695	xcomp	interact,able
R4362	T6698	T6697	prep	with,interact
R4363	T6699	T6698	pobj	elements,with
R4364	T6700	T6699	prep	of,elements
R4365	T6701	T6702	det	the,remodeling
R4366	T6702	T6700	pobj	remodeling,of
R4367	T6703	T6702	compound	chomatin,remodeling
R4368	T6704	T6699	cc	and,elements
R4369	T6705	T6704	punct	/,and
R437	T831	T830	cc	and,genes
R4370	T6706	T6704	cc	or,and
R4371	T6707	T6708	compound	RNA,machinery
R4372	T6708	T6699	conj	machinery,elements
R4373	T6709	T6708	compound	processing,machinery
R4374	T6710	T6697	prep	in,interact
R4375	T6711	T6712	det	the,nucleus
R4376	T6712	T6710	pobj	nucleus,in
R4377	T6713	T6672	punct	.,localized
R4378	T6715	T6716	advmod	Thus,result
R4379	T6717	T6716	punct	", ",result
R438	T832	T833	compound	gene,families
R4380	T6718	T6716	nsubj	changes,result
R4381	T6719	T6718	prep	in,changes
R4382	T6720	T6721	det	the,complement
R4383	T6721	T6719	pobj	complement,in
R4384	T6722	T6721	prep	of,complement
R4385	T6723	T6724	compound	TACC1,isoforms
R4386	T6724	T6722	pobj	isoforms,of
R4387	T6725	T6718	prep	in,changes
R4388	T6726	T6727	det	the,cell
R4389	T6727	T6725	pobj	cell,in
R439	T833	T830	conj	families,genes
R4390	T6728	T6716	aux	may,result
R4391	T6729	T6716	prep	in,result
R4392	T6730	T6729	pobj	alterations,in
R4393	T6731	T6730	prep	in,alterations
R4394	T6732	T6733	amod	cellular,metabolism
R4395	T6733	T6731	pobj	metabolism,in
R4396	T6734	T6733	compound	RNA,metabolism
R4397	T6735	T6730	prep	at,alterations
R4398	T6736	T6737	amod	multiple,levels
R4399	T6737	T6735	pobj	levels,at
R440	T834	T825	punct	", ",trace
R4400	T6738	T6716	punct	", ",result
R4401	T6739	T6716	cc	and,result
R4402	T6740	T6741	aux	may,account
R4403	T6741	T6716	conj	account,result
R4404	T6742	T6741	prep	for,account
R4405	T6743	T6744	det	the,observation
R4406	T6744	T6742	pobj	observation,for
R4407	T6745	T6746	mark	that,associated
R4408	T6746	T6744	acl	associated,observation
R4409	T6747	T6748	nmod	TACC1D,isoforms
R441	T835	T825	prep	with,trace
R4410	T6748	T6746	nsubjpass	isoforms,associated
R4411	T6749	T6747	cc	and,TACC1D
R4412	T6750	T6747	conj	TACC1F,TACC1D
R4413	T6751	T6746	auxpass	are,associated
R4414	T6752	T6746	prep	with,associated
R4415	T6753	T6754	amod	tumorigenic,changes
R4416	T6754	T6752	pobj	changes,with
R4417	T6755	T6746	prep	in,associated
R4418	T6756	T6757	amod	gastric,mucosa
R4419	T6757	T6755	pobj	mucosa,in
R442	T836	T837	amod	related,families
R4420	T6758	T6759	punct	[,18
R4421	T6759	T6744	parataxis	18,observation
R4422	T6760	T6759	punct	],18
R4423	T6761	T6716	punct	.,result
R4426	T7167	T7168	advmod	In,silico
R4427	T7168	T7169	amod	silico,modeling
R4428	T7170	T7169	prep	of,modeling
R4429	T7171	T7172	det	the,evolution
R443	T837	T835	pobj	families,with
R4430	T7172	T7170	pobj	evolution,of
R4431	T7173	T7172	prep	of,evolution
R4432	T7174	T7175	compound	TACC,protein
R4433	T7175	T7176	compound	protein,function
R4434	T7176	T7173	pobj	function,of
R4435	T7178	T7179	det	The,structure
R4436	T7179	T7183	nsubj	structure,suggests
R4437	T7180	T7179	nmod	protein,structure
R4438	T7181	T7180	cc	and,protein
R4439	T7182	T7180	conj	genomic,protein
R444	T838	T837	compound	gene,families
R4440	T7184	T7179	prep	of,structure
R4441	T7185	T7186	det	the,members
R4442	T7186	T7184	pobj	members,of
R4443	T7187	T7188	amod	present,day
R4444	T7188	T7186	compound	day,members
R4445	T7189	T7190	compound	TACC,family
R4446	T7190	T7186	compound	family,members
R4447	T7191	T7192	mark	that,mediated
R4448	T7192	T7183	ccomp	mediated,suggests
R4449	T7193	T7194	det	the,function
R445	T839	T837	prep	in,families
R4450	T7194	T7192	nsubjpass	function,mediated
R4451	T7195	T7194	prep	of,function
R4452	T7196	T7197	det	the,protein
R4453	T7197	T7195	pobj	protein,of
R4454	T7198	T7197	amod	ancestral,protein
R4455	T7199	T7197	compound	TACC,protein
R4456	T7200	T7192	auxpass	was,mediated
R4457	T7201	T7202	advmod	solely,through
R4458	T7202	T7192	prep	through,mediated
R4459	T7203	T7204	det	the,interactions
R446	T840	T841	amod	other,organisms
R4460	T7204	T7202	pobj	interactions,through
R4461	T7205	T7204	prep	of,interactions
R4462	T7206	T7207	det	the,domain
R4463	T7207	T7205	pobj	domain,of
R4464	T7208	T7207	amod	conserved,domain
R4465	T7209	T7207	compound	TACC,domain
R4466	T7210	T7183	punct	.,suggests
R4467	T7212	T7213	advcl	Using,predicted
R4468	T7214	T7215	det	an,model
R4469	T7215	T7212	dobj	model,Using
R447	T841	T839	pobj	organisms,in
R4470	T7216	T7217	advmod	in,silico
R4471	T7217	T7215	amod	silico,model
R4472	T7218	T7219	compound	protein,protein
R4473	T7219	T7221	compound	protein,interaction
R4474	T7220	T7219	punct	-,protein
R4475	T7221	T7215	compound	interaction,model
R4476	T7222	T7215	prep	based,model
R4477	T7223	T7222	prep	upon,based
R4478	T7224	T7225	amod	known,components
R4479	T7225	T7223	pobj	components,upon
R448	T842	T812	punct	.,is
R4480	T7226	T7227	amod	mitotic,spindle
R4481	T7227	T7225	nmod	spindle,components
R4482	T7228	T7227	cc	and,spindle
R4483	T7229	T7227	conj	centrosomal,spindle
R4484	T7230	T7213	punct	", ",predicted
R4485	T7231	T7213	nsubj	we,predicted
R4486	T7232	T7213	aux	have,predicted
R4487	T7233	T7213	advmod	previously,predicted
R4488	T7234	T7235	det	a,number
R4489	T7235	T7213	dobj	number,predicted
R449	T844	T845	advmod	Furthermore,extended
R4490	T7236	T7235	prep	of,number
R4491	T7237	T7238	amod	additional,interactions
R4492	T7238	T7236	pobj	interactions,of
R4493	T7239	T7240	dep	that,conserved
R4494	T7240	T7238	relcl	conserved,interactions
R4495	T7241	T7240	aux	could,conserved
R4496	T7242	T7240	auxpass	be,conserved
R4497	T7243	T7240	prep	between,conserved
R4498	T7244	T7245	det	a,homologue
R4499	T7245	T7243	pobj	homologue,between
R450	T846	T845	punct	", ",extended
R4500	T7246	T7245	amod	functional,homologue
R4501	T7247	T7245	compound	TACC,homologue
R4502	T7248	T7245	prep	in,homologue
R4503	T7249	T7248	pobj	yeast,in
R4504	T7250	T7245	punct	", ",homologue
R4505	T7251	T7245	appos	spc,homologue
R4506	T7252	T7251	punct	-,spc
R4507	T7253	T7251	nummod	72,spc
R4508	T7254	T7245	punct	", ",homologue
R4509	T7255	T7245	cc	and,homologue
R451	T847	T845	prep	with,extended
R4510	T7256	T7257	nummod	one,proteins
R4511	T7257	T7245	conj	proteins,homologue
R4512	T7258	T7256	cc	or,one
R4513	T7259	T7256	conj	more,one
R4514	T7260	T7257	amod	human,proteins
R4515	T7261	T7257	compound	TACC,proteins
R4516	T7262	T7263	punct	[,21
R4517	T7263	T7213	parataxis	21,predicted
R4518	T7264	T7263	punct	],21
R4519	T7265	T7213	punct	.,predicted
R452	T848	T849	det	the,amount
R4520	T7267	T7268	advmod	Thus,known
R4521	T7269	T7268	punct	", ",known
R4522	T7270	T7268	nsubjpass	it,known
R4523	T7271	T7268	auxpass	is,known
R4524	T7272	T7273	mark	that,interact
R4525	T7273	T7268	ccomp	interact,known
R4526	T7274	T7275	predet	all,proteins
R4527	T7275	T7273	nsubj	proteins,interact
R4528	T7276	T7275	det	the,proteins
R4529	T7277	T7275	compound	TACC,proteins
R453	T849	T851	nsubj	amount,becoming
R4530	T7278	T7275	acl	examined,proteins
R4531	T7279	T7278	prep	to,examined
R4532	T7280	T7279	pobj	date,to
R4533	T7281	T7273	punct	", ",interact
R4534	T7282	T7273	prep	via,interact
R4535	T7283	T7284	det	the,domain
R4536	T7284	T7282	pobj	domain,via
R4537	T7285	T7284	compound	TACC,domain
R4538	T7286	T7273	punct	", ",interact
R4539	T7287	T7273	prep	with,interact
R454	T850	T849	amod	growing,amount
R4540	T7288	T7289	det	the,proteins
R4541	T7289	T7287	pobj	proteins,with
R4542	T7290	T7291	npadvmod	microtubule,centrosomal
R4543	T7291	T7289	amod	centrosomal,proteins
R4544	T7292	T7291	punct	/,centrosomal
R4545	T7293	T7289	prep	of,proteins
R4546	T7294	T7295	det	the,family
R4547	T7295	T7293	pobj	family,of
R4548	T7296	T7295	nmod	stu2,family
R4549	T7297	T7296	punct	/,stu2
R455	T851	T847	pcomp	becoming,with
R4550	T7298	T7296	appos	msps,stu2
R4551	T7299	T7296	punct	/,stu2
R4552	T7300	T7301	compound	ch,TOG
R4553	T7301	T7296	appos	TOG,stu2
R4554	T7302	T7301	punct	-,TOG
R4555	T7303	T7304	punct	[,5
R4556	T7304	T7289	parataxis	5,proteins
R4557	T7305	T7304	punct	",",5
R4558	T7306	T7304	appos	6,5
R4559	T7307	T7304	punct	",",5
R456	T852	T849	prep	of,amount
R4560	T7308	T7304	appos	22,5
R4561	T7309	T7310	punct	-,24
R4562	T7310	T7308	prep	24,22
R4563	T7311	T7304	punct	],5
R4564	T7312	T7287	punct	", ",with
R4565	T7313	T7287	cc	and,with
R4566	T7314	T7287	conj	with,with
R4567	T7315	T7316	det	the,kinases
R4568	T7316	T7314	pobj	kinases,with
R4569	T7317	T7316	compound	Aurora,kinases
R457	T853	T854	amod	large,scale
R4570	T7318	T7319	punct	[,25
R4571	T7319	T7316	parataxis	25,kinases
R4572	T7320	T7319	nummod	20,25
R4573	T7321	T7319	punct	",",25
R4574	T7322	T7319	nummod	21,25
R4575	T7323	T7319	punct	",",25
R4576	T7324	T7319	punct	],25
R4577	T7325	T7268	punct	.,known
R4578	T7327	T7328	det	These,interactions
R4579	T7328	T7329	nsubjpass	interactions,required
R458	T854	T856	nmod	scale,data
R4580	T7330	T7329	auxpass	are,required
R4581	T7331	T7329	prep	for,required
R4582	T7332	T7333	det	the,accumulation
R4583	T7333	T7331	pobj	accumulation,for
R4584	T7334	T7333	prep	of,accumulation
R4585	T7335	T7336	det	the,proteins
R4586	T7336	T7334	pobj	proteins,of
R4587	T7337	T7338	nmod	D,TACC
R4588	T7338	T7336	nmod	TACC,proteins
R4589	T7339	T7338	punct	-,TACC
R459	T855	T854	punct	-,scale
R4590	T7340	T7338	punct	", ",TACC
R4591	T7341	T7338	conj	spc72,TACC
R4592	T7342	T7341	punct	", ",spc72
R4593	T7343	T7341	conj	ceTAC1,spc72
R4594	T7344	T7343	cc	and,ceTAC1
R4595	T7345	T7343	conj	TACC3,ceTAC1
R4596	T7346	T7333	prep	to,accumulation
R4597	T7347	T7348	det	the,centrosome
R4598	T7348	T7346	pobj	centrosome,to
R4599	T7349	T7350	punct	[,5
R460	T856	T852	pobj	data,of
R4600	T7350	T7329	parataxis	5,required
R4601	T7351	T7350	punct	",",5
R4602	T7352	T7350	appos	6,5
R4603	T7353	T7350	punct	",",5
R4604	T7354	T7350	appos	22,5
R4605	T7355	T7356	punct	-,24
R4606	T7356	T7354	prep	24,22
R4607	T7357	T7350	punct	],5
R4608	T7358	T7329	punct	.,required
R4609	T7360	T7361	advmod	Hence,is
R461	T857	T856	amod	proteomic,data
R4610	T7362	T7361	punct	", ",is
R4611	T7363	T7364	det	this,interaction
R4612	T7364	T7361	nsubj	interaction,is
R4613	T7365	T7364	amod	functional,interaction
R4614	T7366	T7364	prep	with,interaction
R4615	T7367	T7368	det	the,centrosome
R4616	T7368	T7366	pobj	centrosome,with
R4617	T7369	T7368	cc	and,centrosome
R4618	T7370	T7371	amod	mitotic,spindle
R4619	T7371	T7368	conj	spindle,centrosome
R462	T858	T857	cc	and,proteomic
R4620	T7372	T7361	acomp	likely,is
R4621	T7373	T7374	aux	to,represent
R4622	T7374	T7372	xcomp	represent,likely
R4623	T7375	T7376	det	the,function
R4624	T7376	T7374	dobj	function,represent
R4625	T7377	T7376	amod	ancient,function
R4626	T7378	T7376	punct	", ",function
R4627	T7379	T7376	amod	conserved,function
R4628	T7380	T7376	prep	of,function
R4629	T7381	T7382	det	the,family
R463	T859	T857	conj	genomic,proteomic
R4630	T7382	T7380	pobj	family,of
R4631	T7383	T7382	compound	TACC,family
R4632	T7384	T7361	punct	.,is
R4633	T7386	T7387	advmod	However,is
R4634	T7388	T7387	punct	", ",is
R4635	T7389	T7387	nsubj	it,is
R4636	T7390	T7387	acomp	apparent,is
R4637	T7391	T7392	mark	that,differ
R4638	T7392	T7387	ccomp	differ,is
R4639	T7393	T7394	det	the,proteins
R464	T860	T861	advmod	publicly,available
R4640	T7394	T7392	nsubj	proteins,differ
R4641	T7395	T7394	amod	human,proteins
R4642	T7396	T7394	compound	TACC,proteins
R4643	T7397	T7392	advmod	also,differ
R4644	T7398	T7392	prep	in,differ
R4645	T7399	T7400	poss	their,ability
R4646	T7400	T7398	pobj	ability,in
R4647	T7401	T7402	aux	to,interact
R4648	T7402	T7400	acl	interact,ability
R4649	T7403	T7402	prep	with,interact
R465	T861	T851	acomp	available,becoming
R4650	T7404	T7405	det	the,kinases
R4651	T7405	T7403	pobj	kinases,with
R4652	T7406	T7405	compound	Aurora,kinases
R4653	T7407	T7387	punct	.,is
R4654	T7409	T7410	prep	For,interact
R4655	T7411	T7409	pobj	instance,For
R4656	T7412	T7410	punct	", ",interact
R4657	T7413	T7410	nsubj	TACC1,interact
R4658	T7414	T7413	cc	and,TACC1
R4659	T7415	T7413	conj	TACC3,TACC1
R466	T862	T845	punct	", ",extended
R4660	T7416	T7410	prep	with,interact
R4661	T7417	T7418	compound	Aurora,A
R4662	T7418	T7419	compound	A,kinase
R4663	T7419	T7416	pobj	kinase,with
R4664	T7420	T7410	punct	", ",interact
R4665	T7421	T7422	mark	whereas,interacts
R4666	T7422	T7410	advcl	interacts,interact
R4667	T7423	T7422	nsubj	TACC2,interacts
R4668	T7424	T7422	prep	with,interacts
R4669	T7425	T7426	compound	Aurora,C
R467	T863	T864	det	this,analysis
R4670	T7426	T7427	compound	C,kinase
R4671	T7427	T7424	pobj	kinase,with
R4672	T7428	T7429	punct	[,21
R4673	T7429	T7422	parataxis	21,interacts
R4674	T7430	T7429	punct	],21
R4675	T7431	T7410	punct	", ",interact
R4676	T7432	T7410	advcl	suggesting,interact
R4677	T7433	T7434	det	a,degree
R4678	T7434	T7432	dobj	degree,suggesting
R4679	T7435	T7434	prep	of,degree
R468	T864	T845	nsubjpass	analysis,extended
R4680	T7436	T7437	amod	functional,specialization
R4681	T7437	T7435	pobj	specialization,of
R4682	T7438	T7434	prep	in,degree
R4683	T7439	T7440	det	the,derivatives
R4684	T7440	T7438	pobj	derivatives,in
R4685	T7441	T7440	prep	of,derivatives
R4686	T7442	T7443	det	the,TACC
R4687	T7443	T7441	pobj	TACC,of
R4688	T7444	T7443	amod	ancestral,TACC
R4689	T7445	T7443	compound	chordate,TACC
R469	T865	T845	aux	can,extended
R4690	T7446	T7434	punct	", ",degree
R4691	T7447	T7434	prep	after,degree
R4692	T7448	T7449	det	the,radiation
R4693	T7449	T7447	pobj	radiation,after
R4694	T7450	T7449	prep	of,radiation
R4695	T7451	T7452	det	the,genes
R4696	T7452	T7450	pobj	genes,of
R4697	T7453	T7452	compound	vertebrate,genes
R4698	T7454	T7452	compound	TACC,genes
R4699	T7455	T7410	punct	.,interact
R470	T866	T845	advmod	now,extended
R4700	T7457	T7458	det	The,localization
R4701	T7458	T7459	nsubj	localization,suggests
R4702	T7460	T7458	prep	of,localization
R4703	T7461	T7462	det	the,proteins
R4704	T7462	T7460	pobj	proteins,of
R4705	T7463	T7462	compound	vertebrate,proteins
R4706	T7464	T7462	compound	TACC,proteins
R4707	T7465	T7458	prep	in,localization
R4708	T7466	T7467	det	the,nucleus
R4709	T7467	T7465	pobj	nucleus,in
R471	T867	T845	auxpass	be,extended
R4710	T7468	T7467	compound	interphase,nucleus
R4711	T7469	T7470	punct	[,27
R4712	T7470	T7458	parataxis	27,localization
R4713	T7471	T7470	nummod	15,27
R4714	T7472	T7470	punct	",",27
R4715	T7473	T7470	nummod	26,27
R4716	T7474	T7470	punct	",",27
R4717	T7475	T7470	punct	],27
R4718	T7476	T7477	mark	that,have
R4719	T7477	T7459	ccomp	have,suggests
R472	T868	T869	aux	to,reveal
R4720	T7478	T7477	nsubj	they,have
R4721	T7479	T7480	amod	additional,functions
R4722	T7480	T7477	dobj	functions,have
R4723	T7481	T7480	prep	outside,functions
R4724	T7482	T7483	poss	their,role
R4725	T7483	T7481	pobj	role,outside
R4726	T7484	T7483	amod	ancient,role
R4727	T7485	T7483	prep	in,role
R4728	T7486	T7487	det	the,dynamics
R4729	T7487	T7485	pobj	dynamics,in
R473	T869	T845	advcl	reveal,extended
R4730	T7488	T7487	nmod	centrosome,dynamics
R4731	T7489	T7488	cc	and,centrosome
R4732	T7490	T7488	conj	microtubule,centrosome
R4733	T7491	T7459	punct	.,suggests
R4734	T7493	T7494	advmod	Thus,seems
R4735	T7495	T7494	punct	", ",seems
R4736	T7496	T7494	nsubj	it,seems
R4737	T7497	T7494	oprd	likely,seems
R4738	T7498	T7499	mark	that,integrated
R4739	T7499	T7494	ccomp	integrated,seems
R474	T870	T871	det	the,interplay
R4740	T7500	T7501	compound	TACC,members
R4741	T7501	T7499	nsubj	members,integrated
R4742	T7502	T7501	compound	family,members
R4743	T7503	T7501	prep	in,members
R4744	T7504	T7503	pobj	protostomes,in
R4745	T7505	T7504	cc	and,protostomes
R4746	T7506	T7504	conj	deuterostomes,protostomes
R4747	T7507	T7499	aux	have,integrated
R4748	T7508	T7509	amod	new,functions
R4749	T7509	T7499	dobj	functions,integrated
R475	T871	T869	dobj	interplay,reveal
R4750	T7510	T7509	amod	unique,functions
R4751	T7511	T7512	mark	as,acquired
R4752	T7512	T7499	advcl	acquired,integrated
R4753	T7513	T7514	det	the,genes
R4754	T7514	T7512	nsubj	genes,acquired
R4755	T7515	T7514	amod	evolving,genes
R4756	T7516	T7514	compound	TACC,genes
R4757	T7517	T7518	amod	additional,exons
R4758	T7518	T7512	dobj	exons,acquired
R4759	T7519	T7494	punct	.,seems
R476	T872	T871	amod	complex,interplay
R4760	T7521	T7522	det	The,results
R4761	T7522	T7523	nsubj	results,provide
R4762	T7524	T7522	prep	of,results
R4763	T7525	T7526	det	the,analysis
R4764	T7526	T7524	pobj	analysis,of
R4765	T7527	T7526	nmod	pilot,analysis
R4766	T7528	T7529	amod	large,scale
R4767	T7529	T7526	nmod	scale,analysis
R4768	T7530	T7529	punct	-,scale
R4769	T7531	T7526	amod	proteomic,analysis
R477	T873	T871	prep	between,interplay
R4770	T7532	T7526	prep	in,analysis
R4771	T7533	T7534	compound	C.,elegans
R4772	T7534	T7532	pobj	elegans,in
R4773	T7535	T7534	cc	and,elegans
R4774	T7536	T7537	compound	D.,melanogaster
R4775	T7537	T7534	conj	melanogaster,elegans
R4776	T7538	T7539	amod	further,evidence
R4777	T7539	T7523	dobj	evidence,provide
R4778	T7540	T7539	amod	suggestive,evidence
R4779	T7541	T7539	prep	to,evidence
R478	T874	T873	pobj	evolution,between
R4780	T7542	T7543	det	this,evolution
R4781	T7543	T7541	pobj	evolution,to
R4782	T7544	T7543	amod	functional,evolution
R4783	T7545	T7523	punct	.,provide
R4784	T7547	T7548	nmod	Yeast,analysis
R4785	T7548	T7551	nsubj	analysis,indicates
R4786	T7549	T7550	nummod	two,hybrid
R4787	T7550	T7548	compound	hybrid,analysis
R4788	T7552	T7553	mark	that,binds
R4789	T7553	T7551	ccomp	binds,indicates
R479	T875	T874	prep	of,evolution
R4790	T7554	T7553	nsubj	ceTAC,binds
R4791	T7555	T7553	advmod	directly,binds
R4792	T7556	T7553	prep	to,binds
R4793	T7557	T7558	compound	C.,lin15A
R4794	T7558	T7556	pobj	lin15A,to
R4795	T7559	T7558	compound	elegans,lin15A
R4796	T7560	T7558	punct	", ",lin15A
R4797	T7561	T7558	conj	lin36,lin15A
R4798	T7562	T7561	cc	and,lin36
R4799	T7563	T7561	conj	lin37,lin36
R480	T876	T877	compound	gene,structure
R4800	T7564	T7565	punct	[,28
R4801	T7565	T7551	parataxis	28,indicates
R4802	T7566	T7565	punct	],28
R4803	T7567	T7551	punct	.,indicates
R4804	T7569	T7570	det	These,proteins
R4805	T7570	T7571	nsubj	proteins,bridge
R4806	T7572	T7571	dobj	ceTAC,bridge
R4807	T7573	T7571	prep	to,bridge
R4808	T7574	T7575	amod	other,elements
R4809	T7575	T7573	pobj	elements,to
R481	T877	T875	pobj	structure,of
R4810	T7576	T7575	prep	of,elements
R4811	T7577	T7578	det	the,network
R4812	T7578	T7576	pobj	network,of
R4813	T7579	T7578	nmod	cytoskeleton,network
R4814	T7580	T7579	cc	and,cytoskeleton
R4815	T7581	T7579	conj	microtubule,cytoskeleton
R4816	T7582	T7573	punct	", ",to
R4817	T7583	T7584	advmod	as,as
R4818	T7584	T7573	cc	as,to
R4819	T7585	T7584	advmod	well,as
R482	T878	T874	cc	and,evolution
R4820	T7586	T7573	conj	to,to
R4821	T7587	T7586	pobj	components,to
R4822	T7588	T7587	prep	of,components
R4823	T7589	T7590	det	the,ribosome
R4824	T7590	T7588	pobj	ribosome,of
R4825	T7591	T7587	punct	", ",components
R4826	T7592	T7593	det	the,machinery
R4827	T7593	T7587	appos	machinery,components
R4828	T7594	T7595	nmod	histone,deacetylase
R4829	T7595	T7593	nmod	deacetylase,machinery
R483	T879	T880	compound	protein,function
R4830	T7596	T7593	nmod	chromatin,machinery
R4831	T7597	T7596	amod	remodeling,chromatin
R4832	T7598	T7599	amod	such,as
R4833	T7599	T7593	prep	as,machinery
R4834	T7600	T7599	pobj	egr,as
R4835	T7601	T7600	punct	-,egr
R4836	T7602	T7600	nummod	1,egr
R4837	T7603	T7600	cc	and,egr
R4838	T7604	T7600	conj	lin,egr
R4839	T7605	T7604	punct	-,lin
R484	T880	T874	conj	function,evolution
R4840	T7606	T7604	nummod	53,lin
R4841	T7607	T7600	punct	(,egr
R4842	T7608	T7609	det	the,homologues
R4843	T7609	T7600	appos	homologues,egr
R4844	T7610	T7611	compound	C.,elegans
R4845	T7611	T7609	compound	elegans,homologues
R4846	T7612	T7609	prep	of,homologues
R4847	T7613	T7614	det	the,MTA
R4848	T7614	T7612	pobj	MTA,of
R4849	T7615	T7614	amod	human,MTA
R485	T881	T845	punct	.,extended
R4850	T7616	T7614	punct	-,MTA
R4851	T7617	T7614	nummod	1,MTA
R4852	T7618	T7614	cc	and,MTA
R4853	T7619	T7614	conj	RbAP48,MTA
R4854	T7620	T7600	punct	),egr
R4855	T7621	T7586	punct	", ",to
R4856	T7622	T7586	cc	and,to
R4857	T7623	T7586	conj	to,to
R4858	T7624	T7625	compound	transcription,factors
R4859	T7625	T7623	pobj	factors,to
R486	T883	T884	det	The,gene
R4860	T7626	T7627	amod	such,as
R4861	T7627	T7625	prep	as,factors
R4862	T7628	T7629	det	the,homeobox
R4863	T7629	T7627	pobj	homeobox,as
R4864	T7630	T7629	compound	PAL1,homeobox
R4865	T7631	T7629	cc	and,homeobox
R4866	T7632	T7633	det	the,receptor
R4867	T7633	T7629	conj	receptor,homeobox
R4868	T7634	T7633	amod	nuclear,receptor
R4869	T7635	T7633	compound	hormone,receptor
R487	T884	T890	nsubjpass	gene,identified
R4870	T7636	T7633	appos	nhr,receptor
R4871	T7637	T7636	punct	-,nhr
R4872	T7638	T7636	nummod	86,nhr
R4873	T7639	T7640	punct	[,28
R4874	T7640	T7571	parataxis	28,bridge
R4875	T7641	T7640	punct	],28
R4876	T7642	T7643	punct	(,Fig.
R4877	T7643	T7571	parataxis	Fig.,bridge
R4878	T7644	T7643	nummod	6A,Fig.
R4879	T7645	T7643	punct	),Fig.
R488	T885	T884	amod	first,gene
R4880	T7646	T7571	punct	.,bridge
R4881	T7648	T7649	advmod	Similarly,shown
R4882	T7650	T7649	punct	", ",shown
R4883	T7651	T7652	amod	large,scale
R4884	T7652	T7653	compound	scale,proteomics
R4885	T7653	T7649	nsubj	proteomics,shown
R4886	T7654	T7655	punct	[,29
R4887	T7655	T7653	parataxis	29,proteomics
R4888	T7656	T7655	punct	],29
R4889	T7657	T7649	aux	has,shown
R489	T886	T884	nmod	Transforming,gene
R4890	T7658	T7659	mark	that,interacts
R4891	T7659	T7649	ccomp	interacts,shown
R4892	T7660	T7661	compound	Drosophila,TACC
R4893	T7661	T7659	nsubj	TACC,interacts
R4894	T7662	T7659	prep	with,interacts
R4895	T7663	T7664	nummod	two,proteins
R4896	T7664	T7662	pobj	proteins,with
R4897	T7665	T7664	punct	", ",proteins
R4898	T7666	T7667	det	the,protein
R4899	T7667	T7664	appos	protein,proteins
R490	T887	T884	amod	acidic,gene
R4900	T7668	T7667	compound	RNA,protein
R4901	T7669	T7667	compound	binding,protein
R4902	T7670	T7667	appos	TBPH,protein
R4903	T7671	T7667	cc	and,protein
R4904	T7672	T7667	conj	CG14540,protein
R4905	T7673	T7674	punct	(,Fig.
R4906	T7674	T7664	parataxis	Fig.,proteins
R4907	T7675	T7674	nummod	6B,Fig.
R4908	T7676	T7674	punct	),Fig.
R4909	T7677	T7662	punct	", ",with
R491	T888	T889	amod	coiled,coil
R4910	T7678	T7662	cc	and,with
R4911	T7679	T7680	advmod	thus,with
R4912	T7680	T7662	conj	with,with
R4913	T7681	T7680	advmod	indirectly,with
R4914	T7682	T7683	det	the,complex
R4915	T7683	T7680	pobj	complex,with
R4916	T7684	T7683	compound	Drosophila,complex
R4917	T7685	T7686	compound	SWI,SNF
R4918	T7686	T7683	compound	SNF,complex
R4919	T7687	T7686	punct	/,SNF
R492	T889	T884	compound	coil,gene
R4920	T7688	T7689	compound	chromatin,remodeling
R4921	T7689	T7683	compound	remodeling,complex
R4922	T7690	T7683	cc	and,complex
R4923	T7691	T7692	compound	DNA,damage
R4924	T7692	T7693	compound	damage,repair
R4925	T7693	T7694	compound	repair,machinery
R4926	T7694	T7683	conj	machinery,complex
R4927	T7695	T7649	punct	.,shown
R4928	T7697	T7698	advmod	Significantly,implicated
R4929	T7699	T7698	punct	", ",implicated
R493	T891	T884	punct	", ",gene
R4930	T7700	T7701	det	the,protein
R4931	T7701	T7698	nsubjpass	protein,implicated
R4932	T7702	T7701	compound	ceTAC,protein
R4933	T7703	T7698	aux	has,implicated
R4934	T7704	T7698	advmod	also,implicated
R4935	T7705	T7698	advmod	recently,implicated
R4936	T7706	T7698	auxpass	been,implicated
R4937	T7707	T7698	prep	in,implicated
R4938	T7708	T7709	compound	DNA,repair
R4939	T7709	T7707	pobj	repair,in
R494	T892	T884	appos	TACC1,gene
R4940	T7710	T7698	prep	through,implicated
R4941	T7711	T7712	poss	its,interaction
R4942	T7712	T7710	pobj	interaction,through
R4943	T7713	T7712	amod	direct,interaction
R4944	T7714	T7712	prep	with,interaction
R4945	T7715	T7716	det	the,orthologue
R4946	T7716	T7714	pobj	orthologue,with
R4947	T7717	T7718	compound	C.,elegans
R4948	T7718	T7716	compound	elegans,orthologue
R4949	T7719	T7716	compound	BARD1,orthologue
R495	T893	T890	punct	", ",identified
R4950	T7720	T7721	punct	[,30
R4951	T7721	T7698	parataxis	30,implicated
R4952	T7722	T7721	punct	],30
R4953	T7723	T7698	punct	.,implicated
R4954	T7725	T7726	nsubjpass	It,noted
R4955	T7727	T7726	aux	should,noted
R4956	T7728	T7726	auxpass	be,noted
R4957	T7729	T7730	mark	that,missed
R4958	T7730	T7726	ccomp	missed,noted
R4959	T7731	T7732	det	a,number
R496	T894	T890	auxpass	was,identified
R4960	T7732	T7730	nsubjpass	number,missed
R4961	T7733	T7732	prep	of,number
R4962	T7734	T7733	pobj	interactions,of
R4963	T7735	T7734	prep	with,interactions
R4964	T7736	T7737	det	the,proteins
R4965	T7737	T7735	pobj	proteins,with
R4966	T7738	T7737	compound	TACC,proteins
R4967	T7739	T7737	prep	from,proteins
R4968	T7740	T7741	det	these,organisms
R4969	T7741	T7739	pobj	organisms,from
R497	T895	T890	prep	during,identified
R4970	T7742	T7730	aux	have,missed
R4971	T7743	T7730	advmod	probably,missed
R4972	T7744	T7730	auxpass	been,missed
R4973	T7745	T7730	agent	by,missed
R4974	T7746	T7747	det	these,methods
R4975	T7747	T7745	pobj	methods,by
R4976	T7748	T7749	amod	large,scale
R4977	T7749	T7747	compound	scale,methods
R4978	T7750	T7730	punct	", ",missed
R4979	T7751	T7730	prep	including,missed
R498	T896	T897	det	the,development
R4980	T7752	T7753	det	the,interactions
R4981	T7753	T7751	pobj	interactions,including
R4982	T7754	T7755	advmod	well,documented
R4983	T7755	T7753	amod	documented,interactions
R4984	T7756	T7753	amod	direct,interactions
R4985	T7757	T7753	prep	with,interactions
R4986	T7758	T7759	det	the,kinases
R4987	T7759	T7757	pobj	kinases,with
R4988	T7760	T7759	compound	aurora,kinases
R4989	T7761	T7759	cc	and,kinases
R499	T897	T895	pobj	development,during
R4990	T7762	T7763	det	the,family
R4991	T7763	T7759	conj	family,kinases
R4992	T7764	T7763	nmod	stu2,family
R4993	T7765	T7764	punct	/,stu2
R4994	T7766	T7764	appos	msps,stu2
R4995	T7767	T7764	punct	/,stu2
R4996	T7768	T7769	compound	ch,TOG
R4997	T7769	T7764	appos	TOG,stu2
R4998	T7770	T7769	punct	-,TOG
R4999	T7771	T7726	punct	.,noted
R500	T898	T897	prep	of,development
R5000	T7773	T7774	prep	Because,predict
R5001	T7775	T7773	pcomp	of,Because
R5002	T7776	T7777	det	the,conservation
R5003	T7777	T7773	pobj	conservation,Because
R5004	T7778	T7777	amod	evolutionary,conservation
R5005	T7779	T7777	prep	of,conservation
R5006	T7780	T7781	det	the,domain
R5007	T7781	T7779	pobj	domain,of
R5008	T7782	T7781	compound	TACC,domain
R5009	T7783	T7774	punct	", ",predict
R501	T899	T900	det	an,map
R5010	T7784	T7774	nsubj	we,predict
R5011	T7785	T7774	aux	would,predict
R5012	T7786	T7787	mark	that,observed
R5013	T7787	T7774	ccomp	observed,predict
R5014	T7788	T7787	nsubjpass	some,observed
R5015	T7789	T7788	prep	of,some
R5016	T7790	T7791	det	the,interactions
R5017	T7791	T7789	pobj	interactions,of
R5018	T7792	T7791	amod	functional,interactions
R5019	T7793	T7791	acl	seen,interactions
R502	T900	T898	pobj	map,of
R5020	T7794	T7793	prep	in,seen
R5021	T7795	T7796	compound	C.,elegans
R5022	T7796	T7794	pobj	elegans,in
R5023	T7797	T7796	cc	and,elegans
R5024	T7798	T7799	compound	D.,melanogaster
R5025	T7799	T7796	conj	melanogaster,elegans
R5026	T7800	T7787	aux	would,observed
R5027	T7801	T7787	auxpass	be,observed
R5028	T7802	T7787	prep	in,observed
R5029	T7803	T7804	amod	higher,animals
R503	T901	T900	compound	expression,map
R5030	T7804	T7802	pobj	animals,in
R5031	T7805	T7774	punct	.,predict
R5032	T7807	T7808	amod	Phylogenetic,profiling
R5033	T7808	T7809	nsubj	profiling,suggests
R5034	T7810	T7808	prep	from,profiling
R5035	T7811	T7812	det	these,maps
R5036	T7812	T7810	pobj	maps,from
R5037	T7813	T7812	compound	interaction,maps
R5038	T7814	T7815	nummod	two,sets
R5039	T7815	T7809	dobj	sets,suggests
R504	T902	T900	prep	of,map
R5040	T7816	T7815	amod	similar,sets
R5041	T7817	T7815	prep	of,sets
R5042	T7818	T7819	amod	predicted,interactions
R5043	T7819	T7817	pobj	interactions,of
R5044	T7820	T7815	prep	for,sets
R5045	T7821	T7822	compound	vertebrate,TACCs
R5046	T7822	T7820	pobj	TACCs,for
R5047	T7823	T7824	punct	(,6C
R5048	T7824	T7809	parataxis	6C,suggests
R5049	T7825	T7824	nmod	Fig.,6C
R505	T903	T904	det	the,arm
R5050	T7826	T7824	cc	and,6C
R5051	T7827	T7824	conj	6D,6C
R5052	T7828	T7824	punct	),6C
R5053	T7829	T7809	punct	.,suggests
R5054	T7831	T7832	advmod	Strikingly,have
R5055	T7833	T7832	punct	", ",have
R5056	T7834	T7832	advmod	however,have
R5057	T7835	T7832	punct	", ",have
R5058	T7836	T7837	det	the,proteins
R5059	T7837	T7832	nsubj	proteins,have
R506	T904	T902	pobj	arm,of
R5060	T7838	T7839	compound	C.,elegans
R5061	T7839	T7840	npadvmod	elegans,specific
R5062	T7840	T7837	amod	specific,proteins
R5063	T7841	T7837	appos	lin15A,proteins
R5064	T7842	T7841	punct	", ",lin15A
R5065	T7843	T7841	conj	lin36,lin15A
R5066	T7844	T7843	cc	and,lin36
R5067	T7845	T7843	conj	lin37,lin36
R5068	T7846	T7832	aux	do,have
R5069	T7847	T7832	neg	not,have
R507	T905	T904	amod	proximal,arm
R5070	T7848	T7849	advmod	readily,discernible
R5071	T7849	T7850	amod	discernible,homologues
R5072	T7850	T7832	dobj	homologues,have
R5073	T7851	T7832	prep	in,have
R5074	T7852	T7851	pobj	vertebrates,in
R5075	T7853	T7852	cc	or,vertebrates
R5076	T7854	T7852	conj	Drosophila,vertebrates
R5077	T7855	T7832	punct	", ",have
R5078	T7856	T7857	mark	although,suggest
R5079	T7857	T7832	advcl	suggest,have
R508	T906	T904	amod	short,arm
R5080	T7858	T7859	det	the,presence
R5081	T7859	T7857	nsubj	presence,suggest
R5082	T7860	T7859	prep	of,presence
R5083	T7861	T7862	det	a,domain
R5084	T7862	T7860	pobj	domain,of
R5085	T7863	T7864	compound	zinc,finger
R5086	T7864	T7862	compound	finger,domain
R5087	T7865	T7859	prep	in,presence
R5088	T7866	T7865	pobj	lin36,in
R5089	T7867	T7857	aux	may,suggest
R509	T907	T904	prep	of,arm
R5090	T7868	T7869	mark	that,involved
R5091	T7869	T7857	ccomp	involved,suggest
R5092	T7870	T7871	det	this,protein
R5093	T7871	T7869	nsubjpass	protein,involved
R5094	T7872	T7869	auxpass	is,involved
R5095	T7873	T7869	advmod	directly,involved
R5096	T7874	T7869	prep	in,involved
R5097	T7875	T7874	pobj	transcription,in
R5098	T7876	T7869	cc	or,involved
R5099	T7877	T7869	conj	perform,involved
R510	T908	T909	amod	human,chromosome
R5100	T7878	T7879	det	an,role
R5101	T7879	T7877	dobj	role,perform
R5102	T7880	T7879	compound	adaptor,role
R5103	T7881	T7879	amod	similar,role
R5104	T7882	T7881	prep	to,similar
R5105	T7883	T7884	npadvmod	LIM,containing
R5106	T7884	T7885	amod	containing,proteins
R5107	T7885	T7882	pobj	proteins,to
R5108	T7886	T7832	punct	.,have
R5109	T7888	T7889	prep	For,corresponds
R511	T909	T907	pobj	chromosome,of
R5110	T7890	T7891	det	the,proteins
R5111	T7891	T7888	pobj	proteins,For
R5112	T7892	T7893	npadvmod	DTACC,interacting
R5113	T7893	T7891	amod	interacting,proteins
R5114	T7894	T7889	punct	", ",corresponds
R5115	T7895	T7889	nsubj	TBPH,corresponds
R5116	T7896	T7889	prep	to,corresponds
R5117	T7897	T7896	pobj	TDP43,to
R5118	T7898	T7897	punct	", ",TDP43
R5119	T7899	T7900	det	a,protein
R512	T910	T909	nummod	8,chromosome
R5120	T7900	T7897	appos	protein,TDP43
R5121	T7901	T7900	acl	implicated,protein
R5122	T7902	T7901	prep	in,implicated
R5123	T7903	T7904	amod	transcriptional,regulation
R5124	T7904	T7902	pobj	regulation,in
R5125	T7905	T7904	cc	and,regulation
R5126	T7906	T7904	conj	splicing,regulation
R5127	T7907	T7908	punct	[,32
R5128	T7908	T7889	parataxis	32,corresponds
R5129	T7909	T7908	nummod	31,32
R513	T911	T912	punct	[,1
R5130	T7910	T7908	punct	",",32
R5131	T7911	T7908	punct	],32
R5132	T7912	T7889	punct	.,corresponds
R5133	T7914	T7915	advmod	However,is
R5134	T7916	T7915	punct	", ",is
R5135	T7917	T7918	det	the,assignment
R5136	T7918	T7915	nsubj	assignment,is
R5137	T7919	T7918	prep	of,assignment
R5138	T7920	T7921	det	the,homologue
R5139	T7921	T7919	pobj	homologue,of
R514	T912	T890	parataxis	1,identified
R5140	T7922	T7921	amod	human,homologue
R5141	T7923	T7921	prep	of,homologue
R5142	T7924	T7923	pobj	CG14540,of
R5143	T7925	T7926	advmod	less,clear
R5144	T7926	T7915	acomp	clear,is
R5145	T7927	T7915	punct	", ",is
R5146	T7928	T7915	prep	with,is
R5147	T7929	T7930	det	the,matches
R5148	T7930	T7932	nsubj	matches,corresponding
R5149	T7931	T7930	amod	closest,matches
R515	T913	T912	punct	],1
R5150	T7932	T7928	pcomp	corresponding,with
R5151	T7933	T7930	prep	in,matches
R5152	T7934	T7935	det	the,databases
R5153	T7935	T7933	pobj	databases,in
R5154	T7936	T7935	amod	human,databases
R5155	T7937	T7932	prep	to,corresponding
R5156	T7938	T7939	npadvmod	glutamine,rich
R5157	T7939	T7940	amod	rich,factors
R5158	T7940	T7937	pobj	factors,to
R5159	T7941	T7940	compound	transcription,factors
R516	T914	T890	punct	.,identified
R5160	T7942	T7943	amod	such,as
R5161	T7943	T7940	prep	as,factors
R5162	T7944	T7943	pobj	CREB,as
R5163	T7945	T7944	cc	and,CREB
R5164	T7946	T7947	det	the,factor
R5165	T7947	T7944	conj	factor,CREB
R5166	T7948	T7949	compound	G,box
R5167	T7949	T7947	compound	box,factor
R5168	T7950	T7949	punct	-,box
R5169	T7951	T7947	compound	binding,factor
R517	T916	T917	nummod	Two,members
R5170	T7952	T7915	punct	.,is
R5177	T8333	T8332	prep	of,Comparison
R5178	T8334	T8333	pobj	modeled,of
R5179	T8335	T8332	prep	with,Comparison
R518	T917	T921	nsubjpass	members,identified
R5180	T8336	T8337	advmod	experimentally,defined
R5181	T8337	T8335	pobj	defined,with
R5182	T8338	T8332	appos	interactions,Comparison
R5183	T8339	T8338	prep	of,interactions
R5184	T8340	T8341	det	the,proteins
R5185	T8341	T8339	pobj	proteins,of
R5186	T8342	T8341	compound	vertebrate,proteins
R5187	T8343	T8341	compound	TACC,proteins
R5188	T8345	T8346	det	The,data
R5189	T8346	T8348	nsubj	data,is
R519	T918	T917	amod	additional,members
R5190	T8347	T8346	compound	interaction,data
R5191	T8348	T8353	ccomp	is,beginning
R5192	T8349	T8346	prep	for,data
R5193	T8350	T8351	det	the,TACCs
R5194	T8351	T8349	pobj	TACCs,for
R5195	T8352	T8351	compound	vertebrate,TACCs
R5196	T8354	T8355	advmod	relatively,limited
R5197	T8355	T8348	acomp	limited,is
R5198	T8356	T8353	punct	;,beginning
R5199	T8357	T8353	advmod	however,beginning
R520	T919	T917	compound	TACC,members
R5200	T8358	T8353	punct	", ",beginning
R5201	T8359	T8360	compound	interaction,networks
R5202	T8360	T8353	nsubj	networks,beginning
R5203	T8361	T8353	aux	are,beginning
R5204	T8362	T8353	advmod	now,beginning
R5205	T8363	T8364	aux	to,emerge
R5206	T8364	T8353	xcomp	emerge,beginning
R5207	T8365	T8353	punct	.,beginning
R5208	T8367	T8368	det	The,results
R5209	T8368	T8369	nsubj	results,indicate
R521	T920	T917	compound	family,members
R5210	T8370	T8368	prep	of,results
R5211	T8371	T8372	poss	our,analysis
R5212	T8372	T8370	pobj	analysis,of
R5213	T8373	T8372	amod	functional,analysis
R5214	T8374	T8368	punct	", ",results
R5215	T8375	T8376	advmod	as,as
R5216	T8376	T8368	cc	as,results
R5217	T8377	T8376	advmod	well,as
R5218	T8378	T8379	amod	other,data
R5219	T8379	T8368	conj	data,results
R522	T922	T921	auxpass	were,identified
R5220	T8380	T8379	amod	published,data
R5221	T8381	T8369	advmod	clearly,indicate
R5222	T8382	T8383	mark	that,interact
R5223	T8383	T8369	ccomp	interact,indicate
R5224	T8384	T8385	det	the,TACCs
R5225	T8385	T8383	nsubj	TACCs,interact
R5226	T8386	T8385	compound	vertebrate,TACCs
R5227	T8387	T8383	prep	with,interact
R5228	T8388	T8387	pobj	proteins,with
R5229	T8389	T8390	dep	that,divided
R523	T923	T921	advmod	subsequently,identified
R5230	T8390	T8388	relcl	divided,proteins
R5231	T8391	T8390	aux	can,divided
R5232	T8392	T8390	auxpass	be,divided
R5233	T8393	T8390	prep	into,divided
R5234	T8394	T8395	nummod	two,categories
R5235	T8395	T8393	pobj	categories,into
R5236	T8396	T8395	amod	broad,categories
R5237	T8397	T8369	punct	: ,indicate
R5238	T8398	T8399	meta	1,proteins
R5239	T8401	T8398	punct	),1
R524	T924	T921	cc	and,identified
R5240	T8402	T8399	prep	with,proteins
R5241	T8403	T8402	pobj	roles,with
R5242	T8404	T8403	prep	in,roles
R5243	T8405	T8406	npadvmod	centrosome,mitotic
R5244	T8406	T8408	amod	mitotic,spindle
R5245	T8407	T8406	punct	/,mitotic
R5246	T8408	T8409	compound	spindle,dynamics
R5247	T8409	T8404	pobj	dynamics,in
R5248	T8410	T8399	punct	", ",proteins
R5249	T8411	T8399	cc	and,proteins
R525	T925	T921	conj	mapped,identified
R5250	T8412	T8413	meta	2,proteins
R5251	T8413	T8399	conj	proteins,proteins
R5252	T8414	T8412	punct	),2
R5253	T8415	T8413	acl	involved,proteins
R5254	T8416	T8415	prep	in,involved
R5255	T8417	T8418	compound	gene,regulation
R5256	T8418	T8416	pobj	regulation,in
R5257	T8419	T8415	punct	", ",involved
R5258	T8420	T8421	preconj	either,at
R5259	T8421	T8415	prep	at,involved
R526	T926	T925	prep	to,mapped
R5260	T8422	T8423	det	the,level
R5261	T8423	T8421	pobj	level,at
R5262	T8424	T8423	prep	of,level
R5263	T8425	T8424	pobj	transcription,of
R5264	T8426	T8425	punct	", ",transcription
R5265	T8427	T8425	cc	or,transcription
R5266	T8428	T8429	amod	subsequent,processing
R5267	T8429	T8425	conj	processing,transcription
R5268	T8430	T8429	compound	RNA,processing
R5269	T8431	T8429	cc	and,processing
R527	T927	T928	amod	paralogous,regions
R5270	T8432	T8429	conj	translation,processing
R5271	T8433	T8434	punct	[,3
R5272	T8434	T8415	parataxis	3,involved
R5273	T8435	T8434	punct	",",3
R5274	T8436	T8434	appos	5,3
R5275	T8437	T8438	punct	-,7
R5276	T8438	T8436	prep	7,5
R5277	T8439	T8434	punct	",",3
R5278	T8440	T8434	appos	15,3
R5279	T8441	T8434	punct	",",3
R528	T928	T926	pobj	regions,to
R5280	T8442	T8434	appos	19,3
R5281	T8443	T8444	punct	-,21
R5282	T8444	T8442	prep	21,19
R5283	T8445	T8434	punct	",",3
R5284	T8446	T8434	appos	24,3
R5285	T8447	T8434	punct	",",3
R5286	T8448	T8434	appos	25,3
R5287	T8449	T8434	punct	",",3
R5288	T8450	T8434	appos	33,3
R5289	T8451	T8434	punct	",",3
R529	T929	T928	amod	chromosomal,regions
R5290	T8452	T8434	appos	34,3
R5291	T8453	T8434	punct	],3
R5292	T8454	T8413	punct	.,proteins
R5293	T8456	T8457	nsubj	Many,appear
R5294	T8458	T8456	prep	of,Many
R5295	T8459	T8460	det	these,proteins
R5296	T8460	T8458	pobj	proteins,of
R5297	T8461	T8457	aux	do,appear
R5298	T8462	T8457	neg	not,appear
R5299	T8463	T8464	aux	to,interact
R530	T930	T928	prep	on,regions
R5300	T8464	T8457	xcomp	interact,appear
R5301	T8465	T8464	advmod	directly,interact
R5302	T8466	T8464	prep	with,interact
R5303	T8467	T8468	det	the,TACCs
R5304	T8468	T8466	pobj	TACCs,with
R5305	T8469	T8468	compound	protostome,TACCs
R5306	T8470	T8457	punct	", ",appear
R5307	T8471	T8457	cc	but,appear
R5308	T8472	T8473	aux	would,expected
R5309	T8473	T8457	conj	expected,appear
R531	T931	T932	amod	human,4p16
R5310	T8474	T8473	auxpass	be,expected
R5311	T8475	T8476	aux	to,be
R5312	T8476	T8473	xcomp	be,expected
R5313	T8477	T8476	prep	in,be
R5314	T8478	T8479	det	the,complex
R5315	T8479	T8477	pobj	complex,in
R5316	T8480	T8479	amod	same,complex
R5317	T8481	T8479	compound	protein,complex
R5318	T8482	T8483	punct	(,6D
R5319	T8483	T8473	parataxis	6D,expected
R532	T932	T930	pobj	4p16,on
R5320	T8484	T8483	nmod	Fig.,6D
R5321	T8485	T8483	nummod	6C,6D
R5322	T8486	T8483	punct	",",6D
R5323	T8487	T8483	punct	),6D
R5324	T8488	T8457	punct	.,appear
R5325	T8490	T8491	amod	Significant,analysis
R5326	T8491	T8492	nsubjpass	analysis,published
R5327	T8493	T8491	prep	of,analysis
R5328	T8494	T8495	det	the,association
R5329	T8495	T8493	pobj	association,of
R533	T933	T932	compound	chromosomes,4p16
R5330	T8496	T8495	prep	of,association
R5331	T8497	T8498	det	the,TACCs
R5332	T8498	T8496	pobj	TACCs,of
R5333	T8499	T8495	prep	with,association
R5334	T8500	T8501	det	the,centrosome
R5335	T8501	T8499	pobj	centrosome,with
R5336	T8502	T8495	cc	and,association
R5337	T8503	T8504	det	the,dynamics
R5338	T8504	T8495	conj	dynamics,association
R5339	T8505	T8504	prep	of,dynamics
R534	T934	T932	cc	and,4p16
R5340	T8506	T8507	amod	mitotic,spindle
R5341	T8507	T8508	compound	spindle,assembly
R5342	T8508	T8505	pobj	assembly,of
R5343	T8509	T8491	prep	from,analysis
R5344	T8510	T8509	pobj	yeast,from
R5345	T8511	T8509	prep	to,from
R5346	T8512	T8511	pobj	humans,to
R5347	T8513	T8492	aux	has,published
R5348	T8514	T8492	auxpass	been,published
R5349	T8515	T8516	punct	[,5
R535	T935	T932	conj	10q26,4p16
R5350	T8516	T8492	parataxis	5,published
R5351	T8517	T8516	punct	",",5
R5352	T8518	T8516	appos	6,5
R5353	T8519	T8516	punct	",",5
R5354	T8520	T8516	appos	21,5
R5355	T8521	T8522	punct	-,24
R5356	T8522	T8520	prep	24,21
R5357	T8523	T8516	punct	],5
R5358	T8524	T8492	punct	.,published
R5359	T8526	T8527	prep	From,seems
R536	T936	T932	punct	", ",4p16
R5360	T8528	T8529	det	this,analysis
R5361	T8529	T8526	pobj	analysis,From
R5362	T8530	T8527	punct	", ",seems
R5363	T8531	T8527	nsubj	it,seems
R5364	T8532	T8527	oprd	likely,seems
R5365	T8533	T8534	mark	that,retained
R5366	T8534	T8527	ccomp	retained,seems
R5367	T8535	T8536	det	the,protein
R5368	T8536	T8534	nsubj	protein,retained
R5369	T8537	T8536	compound	vertebrate,protein
R537	T937	T938	advmod	physically,close
R5370	T8538	T8536	compound	TACC3,protein
R5371	T8539	T8534	aux	has,retained
R5372	T8540	T8541	det	this,function
R5373	T8541	T8534	dobj	function,retained
R5374	T8542	T8541	amod	direct,function
R5375	T8543	T8541	amod	ancestral,function
R5376	T8544	T8527	punct	", ",seems
R5377	T8545	T8527	prep	based,seems
R5378	T8546	T8545	prep	upon,based
R5379	T8547	T8548	poss	its,location
R538	T938	T932	amod	close,4p16
R5380	T8548	T8546	pobj	location,upon
R5381	T8549	T8548	prep	in,location
R5382	T8550	T8551	det	these,structures
R5383	T8551	T8549	pobj	structures,in
R5384	T8552	T8548	prep	during,location
R5385	T8553	T8552	pobj	mitosis,during
R5386	T8554	T8555	punct	[,27
R5387	T8555	T8548	parataxis	27,location
R5388	T8556	T8555	punct	],27
R5389	T8557	T8548	punct	", ",location
R539	T939	T938	prep	to,close
R5390	T8558	T8559	poss	its,interaction
R5391	T8559	T8548	conj	interaction,location
R5392	T8560	T8559	amod	strong,interaction
R5393	T8561	T8559	prep	with,interaction
R5394	T8562	T8563	compound	Aurora,A
R5395	T8563	T8561	pobj	A,with
R5396	T8564	T8563	compound	Kinase,A
R5397	T8565	T8559	punct	", ",interaction
R5398	T8566	T8559	cc	and,interaction
R5399	T8567	T8568	det	the,observation
R540	T940	T939	pobj	members,to
R5400	T8568	T8559	conj	observation,interaction
R5401	T8569	T8570	mark	that,is
R5402	T8570	T8568	acl	is,observation
R5403	T8571	T8570	nsubj	it,is
R5404	T8572	T8573	det	the,protein
R5405	T8573	T8570	attr	protein,is
R5406	T8574	T8573	advmod	only,protein
R5407	T8575	T8573	amod	human,protein
R5408	T8576	T8573	compound	TACC,protein
R5409	T8577	T8573	acl	phosphorylated,protein
R541	T941	T940	prep	of,members
R5410	T8578	T8577	agent	by,phosphorylated
R5411	T8579	T8580	det	this,enzyme
R5412	T8580	T8578	pobj	enzyme,by
R5413	T8581	T8582	punct	[,21
R5414	T8582	T8568	parataxis	21,observation
R5415	T8583	T8582	punct	],21
R5416	T8584	T8527	punct	.,seems
R5417	T8586	T8587	advmod	However,suggests
R5418	T8588	T8587	punct	", ",suggests
R5419	T8589	T8590	det	the,variability
R542	T942	T943	det	the,family
R5420	T8590	T8587	nsubj	variability,suggests
R5421	T8591	T8590	prep	of,variability
R5422	T8592	T8593	det	the,domain
R5423	T8593	T8591	pobj	domain,of
R5424	T8594	T8593	amod	central,domain
R5425	T8595	T8593	prep	of,domain
R5426	T8596	T8597	det	the,orthologues
R5427	T8597	T8595	pobj	orthologues,of
R5428	T8598	T8597	compound	vertebrate,orthologues
R5429	T8599	T8587	punct	", ",suggests
R543	T943	T941	pobj	family,of
R5430	T8600	T8601	mark	that,acquired
R5431	T8601	T8587	ccomp	acquired,suggests
R5432	T8602	T8601	nsubj	TACC3,acquired
R5433	T8603	T8601	aux	may,acquired
R5434	T8604	T8601	advmod	also,acquired
R5435	T8605	T8601	aux	have,acquired
R5436	T8606	T8607	amod	additional,functions
R5437	T8607	T8601	dobj	functions,acquired
R5438	T8608	T8606	punct	", ",additional
R5439	T8609	T8606	cc	and,additional
R544	T944	T943	compound	FGFR,family
R5440	T8610	T8611	prep	in,specific
R5441	T8611	T8606	conj	specific,additional
R5442	T8612	T8613	det	some,instances
R5443	T8613	T8610	pobj	instances,in
R5444	T8614	T8611	punct	", ",specific
R5445	T8615	T8611	npadvmod	species,specific
R5446	T8616	T8611	punct	-,specific
R5447	T8617	T8587	punct	.,suggests
R5448	T8619	T8620	prep	For,acquired
R5449	T8621	T8619	pobj	instance,For
R545	T945	T943	compound	gene,family
R5450	T8622	T8620	punct	", ",acquired
R5451	T8623	T8620	prep	in,acquired
R5452	T8624	T8625	compound	X.,laevis
R5453	T8625	T8623	pobj	laevis,in
R5454	T8626	T8620	punct	", ",acquired
R5455	T8627	T8628	det	the,protein
R5456	T8628	T8620	nsubj	protein,acquired
R5457	T8629	T8628	compound	maskin,protein
R5458	T8630	T8620	aux	has,acquired
R5459	T8631	T8632	det	a,site
R546	T946	T947	punct	[,1
R5460	T8632	T8620	dobj	site,acquired
R5461	T8633	T8632	compound	binding,site
R5462	T8634	T8632	prep	for,site
R5463	T8635	T8636	det	the,protein
R5464	T8636	T8634	pobj	protein,for
R5465	T8637	T8636	compound	eIF4E,protein
R5466	T8638	T8632	punct	", ",site
R5467	T8639	T8632	cc	and,site
R5468	T8640	T8641	advmod	thus,function
R5469	T8641	T8632	conj	function,site
R547	T947	T925	parataxis	1,mapped
R5470	T8642	T8641	det	a,function
R5471	T8643	T8641	prep	in,function
R5472	T8644	T8645	det	the,control
R5473	T8645	T8643	pobj	control,in
R5474	T8646	T8645	amod	coordinated,control
R5475	T8647	T8645	prep	of,control
R5476	T8648	T8647	pobj	polyadenylation,of
R5477	T8649	T8648	cc	and,polyadenylation
R5478	T8650	T8648	conj	translation,polyadenylation
R5479	T8651	T8641	prep	in,function
R548	T948	T949	punct	-,3
R5480	T8652	T8653	det	the,oocyte
R5481	T8653	T8651	pobj	oocyte,in
R5482	T8654	T8653	compound	Xenopus,oocyte
R5483	T8655	T8656	punct	[,35
R5484	T8656	T8620	parataxis	35,acquired
R5485	T8657	T8656	nummod	8,35
R5486	T8658	T8656	punct	",",35
R5487	T8659	T8656	punct	],35
R5488	T8660	T8620	punct	.,acquired
R5489	T8662	T8663	det	A,study
R549	T949	T947	prep	3,1
R5490	T8663	T8665	nsubj	study,suggested
R5491	T8664	T8663	amod	recent,study
R5492	T8665	T8667	ccomp	suggested,is
R5493	T8666	T8665	aux	has,suggested
R5494	T8668	T8669	mark	that,be
R5495	T8669	T8665	ccomp	be,suggested
R5496	T8670	T8671	det	this,function
R5497	T8671	T8669	nsubj	function,be
R5498	T8672	T8669	aux	may,be
R5499	T8673	T8669	acomp	unique,be
R550	T950	T947	punct	],1
R5500	T8674	T8673	prep	to,unique
R5501	T8675	T8674	pobj	maskin,to
R5502	T8676	T8667	punct	: ,is
R5503	T8677	T8678	mark	although,is
R5504	T8678	T8667	advcl	is,is
R5505	T8679	T8678	nsubj	it,is
R5506	T8680	T8678	acomp	unclear,is
R5507	T8681	T8682	mark	whether,interact
R5508	T8682	T8678	ccomp	interact,is
R5509	T8683	T8684	det	the,proteins
R551	T951	T921	punct	.,identified
R5510	T8684	T8682	nsubj	proteins,interact
R5511	T8685	T8684	amod	other,proteins
R5512	T8686	T8684	compound	vertebrate,proteins
R5513	T8687	T8684	compound	TACC3,proteins
R5514	T8688	T8682	prep	with,interact
R5515	T8689	T8690	det	the,complex
R5516	T8690	T8688	pobj	complex,with
R5517	T8691	T8692	compound	eIF4E,CPEB
R5518	T8692	T8690	compound	CPEB,complex
R5519	T8693	T8692	punct	/,CPEB
R552	T953	T954	det	This,data
R5520	T8694	T8667	punct	", ",is
R5521	T8695	T8696	det	the,isoform
R5522	T8696	T8667	nsubj	isoform,is
R5523	T8697	T8696	amod	human,isoform
R5524	T8698	T8696	compound	TACC1A,isoform
R5525	T8699	T8667	acomp	unable,is
R5526	T8700	T8701	aux	to,interact
R5527	T8701	T8699	xcomp	interact,unable
R5528	T8702	T8701	prep	with,interact
R5529	T8703	T8704	det	the,complex
R553	T954	T956	nsubj	data,led
R5530	T8704	T8702	pobj	complex,with
R5531	T8705	T8706	compound	eIF4E,CPEB
R5532	T8706	T8704	compound	CPEB,complex
R5533	T8707	T8706	punct	/,CPEB
R5534	T8708	T8667	punct	.,is
R5535	T8710	T8711	advmod	Instead,evolved
R5536	T8712	T8711	punct	", ",evolved
R5537	T8713	T8714	det	some,isoforms
R5538	T8714	T8711	nsubj	isoforms,evolved
R5539	T8715	T8714	compound	TACC1,isoforms
R554	T955	T954	compound	mapping,data
R5540	T8716	T8711	aux	have,evolved
R5541	T8717	T8718	det	a,function
R5542	T8718	T8711	dobj	function,evolved
R5543	T8719	T8718	amod	related,function
R5544	T8720	T8719	punct	", ",related
R5545	T8721	T8719	cc	but,related
R5546	T8722	T8719	conj	distinct,related
R5547	T8723	T8711	prep	by,evolved
R5548	T8724	T8725	advmod	directly,interacting
R5549	T8725	T8723	pcomp	interacting,by
R555	T957	T954	punct	", ",data
R5550	T8726	T8725	prep	with,interacting
R5551	T8727	T8726	pobj	elements,with
R5552	T8728	T8727	prep	of,elements
R5553	T8729	T8730	det	the,machinery
R5554	T8730	T8728	pobj	machinery,of
R5555	T8731	T8732	nmod	RNA,splicing
R5556	T8732	T8730	nmod	splicing,machinery
R5557	T8733	T8732	cc	and,splicing
R5558	T8734	T8732	conj	transport,splicing
R5559	T8735	T8736	punct	[,19
R556	T958	T959	advmod	together,with
R5560	T8736	T8711	parataxis	19,evolved
R5561	T8737	T8736	punct	],19
R5562	T8738	T8711	punct	.,evolved
R5563	T8740	T8741	aux	To,characterize
R5564	T8741	T8743	advcl	characterize,used
R5565	T8742	T8741	advmod	further,characterize
R5566	T8744	T8745	det	the,functions
R5567	T8745	T8741	dobj	functions,characterize
R5568	T8746	T8745	amod	evolving,functions
R5569	T8747	T8745	prep	of,functions
R557	T959	T954	prep	with,data
R5570	T8748	T8749	det	the,proteins
R5571	T8749	T8747	pobj	proteins,of
R5572	T8750	T8749	compound	TACC,proteins
R5573	T8751	T8743	punct	", ",used
R5574	T8752	T8743	nsubj	we,used
R5575	T8753	T8743	aux	have,used
R5576	T8754	T8755	det	an,method
R5577	T8755	T8743	dobj	method,used
R5578	T8756	T8755	amod	unbiased,method
R5579	T8757	T8755	nmod	yeast,method
R558	T960	T959	pobj	identification,with
R5580	T8758	T8759	nummod	two,hybrid
R5581	T8759	T8755	compound	hybrid,method
R5582	T8760	T8755	compound	screening,method
R5583	T8761	T8762	aux	to,identify
R5584	T8762	T8743	advcl	identify,used
R5585	T8763	T8762	dobj	proteins,identify
R5586	T8764	T8765	dep	that,bind
R5587	T8765	T8763	relcl	bind,proteins
R5588	T8766	T8765	prep	to,bind
R5589	T8767	T8768	det	the,proteins
R559	T961	T960	prep	of,identification
R5590	T8768	T8766	pobj	proteins,to
R5591	T8769	T8768	amod	human,proteins
R5592	T8770	T8768	compound	TACC,proteins
R5593	T8771	T8772	punct	[,34
R5594	T8772	T8743	parataxis	34,used
R5595	T8773	T8772	nummod	3,34
R5596	T8774	T8772	punct	",",34
R5597	T8775	T8772	punct	],34
R5598	T8776	T8743	punct	.,used
R5599	T8778	T8779	prep	In,identified
R560	T962	T963	det	a,gene
R5600	T8780	T8781	det	a,screen
R5601	T8781	T8778	pobj	screen,In
R5602	T8782	T8781	prep	of,screen
R5603	T8783	T8784	det	a,library
R5604	T8784	T8782	pobj	library,of
R5605	T8785	T8784	nmod	MATCHMAKER,library
R5606	T8786	T8787	amod	fetal,brain
R5607	T8787	T8784	compound	brain,library
R5608	T8788	T8789	punct	(,Clontech
R5609	T8789	T8784	parataxis	Clontech,library
R561	T963	T961	pobj	gene,of
R5610	T8790	T8789	compound	BD,Clontech
R5611	T8791	T8789	compound	Biosciences,Clontech
R5612	T8792	T8789	punct	),Clontech
R5613	T8793	T8779	punct	", ",identified
R5614	T8794	T8779	prep	in,identified
R5615	T8795	T8794	pobj	addition,in
R5616	T8796	T8795	prep	to,addition
R5617	T8797	T8796	pcomp	isolating,to
R5618	T8798	T8799	det	the,acetyltransferase
R5619	T8799	T8797	dobj	acetyltransferase,isolating
R562	T964	T963	amod	single,gene
R5620	T8800	T8799	compound	histone,acetyltransferase
R5621	T8801	T8799	appos	hGCN5L2,acetyltransferase
R5622	T8802	T8803	punct	[,34
R5623	T8803	T8797	parataxis	34,isolating
R5624	T8804	T8803	punct	],34
R5625	T8805	T8779	punct	", ",identified
R5626	T8806	T8779	nsubj	we,identified
R5627	T8807	T8779	advmod	also,identified
R5628	T8808	T8809	det	the,isoform
R5629	T8809	T8779	dobj	isoform,identified
R563	T965	T963	compound	TACC,gene
R5630	T8810	T8809	compound	β3,isoform
R5631	T8811	T8809	prep	of,isoform
R5632	T8812	T8813	compound	retinoid,X
R5633	T8813	T8815	compound	X,β
R5634	T8814	T8813	punct	-,X
R5635	T8815	T8811	pobj	β,of
R5636	T8816	T8815	compound	receptor,β
R5637	T8817	T8779	prep	as,identified
R5638	T8818	T8819	det	a,protein
R5639	T8819	T8817	pobj	protein,as
R564	T966	T960	prep	in,identification
R5640	T8820	T8821	dep	that,interacts
R5641	T8821	T8819	relcl	interacts,protein
R5642	T8822	T8821	prep	with,interacts
R5643	T8823	T8824	det	the,domain
R5644	T8824	T8822	pobj	domain,with
R5645	T8825	T8824	compound	TACC,domain
R5646	T8826	T8824	prep	of,domain
R5647	T8827	T8826	pobj	TACC2,of
R5648	T8828	T8779	punct	.,identified
R5649	T8830	T8831	mark	As,shown
R565	T967	T968	det	the,elegans
R5650	T8831	T8832	advcl	shown,confirmed
R5651	T8833	T8831	prep	in,shown
R5652	T8834	T8833	pobj	Fig.,in
R5653	T8835	T8834	nummod	7,Fig.
R5654	T8836	T8832	punct	", ",confirmed
R5655	T8837	T8838	det	this,interaction
R5656	T8838	T8832	nsubjpass	interaction,confirmed
R5657	T8839	T8832	auxpass	is,confirmed
R5658	T8840	T8841	advmod	in,vitro
R5659	T8841	T8832	advmod	vitro,confirmed
R566	T968	T966	pobj	elegans,in
R5660	T8842	T8832	prep	by,confirmed
R5661	T8843	T8844	npadvmod	GST,pull
R5662	T8844	T8846	amod	pull,analysis
R5663	T8845	T8844	punct	-,pull
R5664	T8846	T8842	pobj	analysis,by
R5665	T8847	T8844	prt	down,pull
R5666	T8848	T8832	punct	.,confirmed
R5667	T8850	T8851	advmod	Significantly,is
R5668	T8852	T8851	punct	", ",is
R5669	T8853	T8851	nsubj	RXRβ,is
R567	T969	T968	compound	protostomes,elegans
R5670	T8854	T8855	det	a,family
R5671	T8855	T8851	attr	family,is
R5672	T8856	T8855	amod	close,family
R5673	T8857	T8855	amod	relative,family
R5674	T8858	T8855	prep	of,family
R5675	T8859	T8860	det	the,receptor
R5676	T8860	T8858	pobj	receptor,of
R5677	T8861	T8860	amod	nuclear,receptor
R5678	T8862	T8860	compound	hormone,receptor
R5679	T8863	T8860	punct	", ",receptor
R568	T970	T968	compound	Caenorhabitis,elegans
R5680	T8864	T8860	appos	nhr,receptor
R5681	T8865	T8864	punct	-,nhr
R5682	T8866	T8864	nummod	86,nhr
R5683	T8867	T8860	punct	", ",receptor
R5684	T8868	T8860	prep	from,receptor
R5685	T8869	T8870	compound	C.,elegans
R5686	T8870	T8868	pobj	elegans,from
R5687	T8871	T8870	punct	", ",elegans
R5688	T8872	T8873	dep	which,interacts
R5689	T8873	T8870	relcl	interacts,elegans
R569	T971	T968	punct	", ",elegans
R5690	T8874	T8873	prep	with,interacts
R5691	T8875	T8876	det	the,protein
R5692	T8876	T8874	pobj	protein,with
R5693	T8877	T8876	compound	ceTAC,protein
R5694	T8878	T8876	compound	binding,protein
R5695	T8879	T8876	appos	lin36,protein
R5696	T8880	T8881	punct	(,Fig.
R5697	T8881	T8873	parataxis	Fig.,interacts
R5698	T8882	T8881	nummod	6A,Fig.
R5699	T8883	T8881	punct	),Fig.
R570	T972	T968	cc	and,elegans
R5700	T8884	T8851	punct	.,is
R5701	T8886	T8887	nsubj	This,suggests
R5702	T8888	T8889	mark	that,evolved
R5703	T8889	T8887	ccomp	evolved,suggests
R5704	T8890	T8891	mark	while,require
R5705	T8891	T8889	advcl	require,evolved
R5706	T8892	T8893	compound	protostome,TACCs
R5707	T8893	T8891	nsubj	TACCs,require
R5708	T8894	T8891	aux	may,require
R5709	T8895	T8896	amod	additional,factors
R571	T973	T974	compound	Drosophila,melanogaster
R5710	T8896	T8891	dobj	factors,require
R5711	T8897	T8896	compound	protein,factors
R5712	T8898	T8899	aux	to,interact
R5713	T8899	T8891	advcl	interact,require
R5714	T8900	T8899	prep	with,interact
R5715	T8901	T8902	amod	such,components
R5716	T8902	T8900	pobj	components,with
R5717	T8903	T8889	punct	", ",evolved
R5718	T8904	T8905	det	the,TACCs
R5719	T8905	T8889	nsubj	TACCs,evolved
R572	T974	T968	conj	melanogaster,elegans
R5720	T8906	T8905	prep	in,TACCs
R5721	T8907	T8908	amod	higher,organisms
R5722	T8908	T8906	pobj	organisms,in
R5723	T8909	T8889	aux	may,evolved
R5724	T8910	T8889	aux	have,evolved
R5725	T8911	T8912	det	the,ability
R5726	T8912	T8889	dobj	ability,evolved
R5727	T8913	T8914	aux	to,interact
R5728	T8914	T8912	acl	interact,ability
R5729	T8915	T8914	advmod	directly,interact
R573	T975	T976	punct	[,4
R5730	T8916	T8914	prep	with,interact
R5731	T8917	T8916	pobj	some,with
R5732	T8918	T8917	prep	of,some
R5733	T8919	T8920	det	the,proteins
R5734	T8920	T8918	pobj	proteins,of
R5735	T8921	T8914	prep	in,interact
R5736	T8922	T8923	det	the,map
R5737	T8923	T8921	pobj	map,in
R5738	T8924	T8923	amod	predicted,map
R5739	T8925	T8923	compound	interaction,map
R574	T976	T954	parataxis	4,data
R5740	T8926	T8927	punct	(,Fig.
R5741	T8927	T8887	parataxis	Fig.,suggests
R5742	T8928	T8927	nummod	6E,Fig.
R5743	T8929	T8927	punct	),Fig.
R5744	T8930	T8887	punct	.,suggests
R5745	T8932	T8933	advmod	Indeed,appears
R5746	T8934	T8933	punct	", ",appears
R5747	T8935	T8933	nsubj	this,appears
R5748	T8936	T8937	aux	to,linked
R5749	T8937	T8933	xcomp	linked,appears
R575	T977	T978	punct	-,6
R5750	T8938	T8937	auxpass	be,linked
R5751	T8939	T8937	advmod	directly,linked
R5752	T8940	T8937	prep	to,linked
R5753	T8941	T8942	det	the,acquisition
R5754	T8942	T8940	pobj	acquisition,to
R5755	T8943	T8942	prep	of,acquisition
R5756	T8944	T8945	amod	new,domains
R5757	T8945	T8943	pobj	domains,of
R5758	T8946	T8942	cc	and,acquisition
R5759	T8947	T8942	conj	duplication,acquisition
R576	T978	T976	prep	6,4
R5760	T8948	T8947	prep	of,duplication
R5761	T8949	T8950	det	the,precursor
R5762	T8950	T8948	pobj	precursor,of
R5763	T8951	T8950	compound	chordate,precursor
R5764	T8952	T8950	compound	TACC,precursor
R5765	T8953	T8933	punct	.,appears
R5766	T8955	T8956	prep	In,was
R5767	T8957	T8955	pobj	fact,In
R5768	T8958	T8956	punct	", ",was
R5769	T8959	T8960	det	the,function
R577	T979	T976	punct	],4
R5770	T8960	T8956	nsubj	function,was
R5771	T8961	T8960	amod	first,function
R5772	T8962	T8960	amod	identified,function
R5773	T8963	T8960	prep	of,function
R5774	T8964	T8965	det	a,protein
R5775	T8965	T8963	pobj	protein,of
R5776	T8966	T8965	compound	vertebrate,protein
R5777	T8967	T8965	compound	TACC,protein
R5778	T8968	T8956	prep	as,was
R5779	T8969	T8970	det	a,coactivator
R578	T980	T956	punct	", ",led
R5780	T8970	T8968	pobj	coactivator,as
R5781	T8971	T8970	amod	transcriptional,coactivator
R5782	T8972	T8970	acl	acting,coactivator
R5783	T8973	T8972	prep	through,acting
R5784	T8974	T8975	det	a,interaction
R5785	T8975	T8973	pobj	interaction,through
R5786	T8976	T8975	amod	direct,interaction
R5787	T8977	T8975	prep	with,interaction
R5788	T8978	T8979	det	the,factor
R5789	T8979	T8977	pobj	factor,with
R579	T981	T956	prep	to,led
R5790	T8980	T8979	compound	ARNT,factor
R5791	T8981	T8979	compound	transcription,factor
R5792	T8982	T8983	punct	[,7
R5793	T8983	T8956	parataxis	7,was
R5794	T8984	T8983	punct	],7
R5795	T8985	T8956	punct	.,was
R5796	T8987	T8988	nsubj	It,is
R5797	T8989	T8988	advmod	also,is
R5798	T8990	T8988	acomp	intriguing,is
R5799	T8991	T8992	mark	that,interacts
R580	T982	T983	det	the,speculation
R5800	T8992	T8988	ccomp	interacts,is
R5801	T8993	T8994	det	the,repeat
R5802	T8994	T8992	nsubj	repeat,interacts
R5803	T8995	T8996	npadvmod	deuterostome,specific
R5804	T8996	T8994	amod	specific,repeat
R5805	T8997	T8994	compound	SDP,repeat
R5806	T8998	T8992	prep	with,interacts
R5807	T8999	T8998	pobj	GAS41,with
R5808	T9000	T8999	punct	", ",GAS41
R5809	T9001	T9002	det	a,factor
R581	T983	T981	pobj	speculation,to
R5810	T9002	T8999	appos	factor,GAS41
R5811	T9003	T9004	compound	component,accessory
R5812	T9004	T9002	compound	accessory,factor
R5813	T9005	T9004	punct	/,accessory
R5814	T9006	T9002	prep	of,factor
R5815	T9007	T9008	det	the,complex
R5816	T9008	T9006	pobj	complex,of
R5817	T9009	T9008	amod	human,complex
R5818	T9010	T9011	compound	SWI,SNF
R5819	T9011	T9008	compound	SNF,complex
R582	T984	T985	mark	that,located
R5820	T9012	T9011	punct	/,SNF
R5821	T9013	T9014	compound	chromatin,remodeling
R5822	T9014	T9008	compound	remodeling,complex
R5823	T9015	T9016	punct	[,15
R5824	T9016	T8988	parataxis	15,is
R5825	T9017	T9016	nummod	3,15
R5826	T9018	T9016	punct	",",15
R5827	T9019	T9016	punct	],15
R5828	T9020	T8988	punct	.,is
R5829	T9022	T9023	mark	Although,is
R583	T985	T983	acl	located,speculation
R5830	T9023	T9025	advcl	is,indicate
R5831	T9024	T9023	expl	there,is
R5832	T9026	T9027	det	a,homologue
R5833	T9027	T9023	attr	homologue,is
R5834	T9028	T9029	compound	D.,melanogaster
R5835	T9029	T9027	compound	melanogaster,homologue
R5836	T9030	T9027	prep	of,homologue
R5837	T9031	T9030	pobj	GAS41,of
R5838	T9032	T9027	punct	", ",homologue
R5839	T9033	T9027	appos	dmGAS41,homologue
R584	T986	T987	det	the,genes
R5840	T9034	T9025	punct	", ",indicate
R5841	T9035	T9036	det	the,database
R5842	T9036	T9025	nsubj	database,indicate
R5843	T9037	T9038	amod	large,scale
R5844	T9038	T9039	nmod	scale,interaction
R5845	T9039	T9036	compound	interaction,database
R5846	T9040	T9039	amod	proteomic,interaction
R5847	T9041	T9025	aux	does,indicate
R5848	T9042	T9025	neg	not,indicate
R5849	T9043	T9044	det	a,interaction
R585	T987	T985	nsubjpass	genes,located
R5850	T9044	T9025	dobj	interaction,indicate
R5851	T9045	T9044	amod	direct,interaction
R5852	T9046	T9044	prep	of,interaction
R5853	T9047	T9046	pobj	dmGAS41,of
R5854	T9048	T9044	prep	with,interaction
R5855	T9049	T9048	pobj	DTACC,with
R5856	T9050	T9025	punct	.,indicate
R5857	T9052	T9053	nsubj	This,be
R5858	T9054	T9053	aux	may,be
R5859	T9055	T9053	prep	due,be
R586	T988	T987	amod	ancestral,genes
R5860	T9056	T9055	pcomp	to,due
R5861	T9057	T9058	det	the,lack
R5862	T9058	T9055	pobj	lack,due
R5863	T9059	T9058	prep	of,lack
R5864	T9060	T9061	det	the,region
R5865	T9061	T9059	pobj	region,of
R5866	T9062	T9063	compound	SDP,repeat
R5867	T9063	T9061	compound	repeat,region
R5868	T9064	T9058	prep	in,lack
R5869	T9065	T9066	det	the,protein
R587	T989	T987	nmod	FGFR,genes
R5870	T9066	T9064	pobj	protein,in
R5871	T9067	T9066	compound	Drosophila,protein
R5872	T9068	T9066	compound	TACC,protein
R5873	T9069	T9053	punct	.,be
R5874	T9071	T9072	nsubj	This,suggests
R5875	T9073	T9072	advmod	further,suggests
R5876	T9074	T9075	mark	that,gained
R5877	T9075	T9072	advcl	gained,suggests
R5878	T9076	T9077	det	the,TACCs
R5879	T9077	T9075	nsubj	TACCs,gained
R588	T990	T989	cc	and,FGFR
R5880	T9078	T9077	compound	vertebrate,TACCs
R5881	T9079	T9075	aux	have,gained
R5882	T9080	T9081	det	the,ability
R5883	T9081	T9075	dobj	ability,gained
R5884	T9082	T9081	amod	specific,ability
R5885	T9083	T9084	aux	to,interact
R5886	T9084	T9081	acl	interact,ability
R5887	T9085	T9084	amod	direct,interact
R5888	T9086	T9084	prep	with,interact
R5889	T9087	T9088	amod	transcriptional,complexes
R589	T991	T989	conj	TACC,FGFR
R5890	T9088	T9086	pobj	complexes,with
R5891	T9089	T9088	amod	regulatory,complexes
R5892	T9090	T9075	punct	", ",gained
R5893	T9091	T9075	cc	and,gained
R5894	T9092	T9093	mark	that,required
R5895	T9093	T9075	conj	required,gained
R5896	T9094	T9095	amod	bridging,protein
R5897	T9095	T9093	nsubjpass	protein,required
R5898	T9096	T9095	punct	(,protein
R5899	T9097	T9095	nmod	s,protein
R590	T992	T985	auxpass	were,located
R5900	T9098	T9095	punct	),protein
R5901	T9099	T9093	auxpass	are,required
R5902	T9100	T9101	neg	no,longer
R5903	T9101	T9093	advmod	longer,required
R5904	T9102	T9072	punct	.,suggests
R5905	T9104	T9105	advmod	Thus,integrated
R5906	T9106	T9105	punct	", ",integrated
R5907	T9107	T9108	advmod	where,composed
R5908	T9108	T9105	advcl	composed,integrated
R5909	T9109	T9110	det	the,protein
R591	T993	T994	advmod	physically,close
R5910	T9110	T9108	nsubjpass	protein,composed
R5911	T9111	T9110	compound	ceTAC,protein
R5912	T9112	T9108	auxpass	is,composed
R5913	T9113	T9108	advmod	only,composed
R5914	T9114	T9108	prep	of,composed
R5915	T9115	T9116	det	the,domain
R5916	T9116	T9114	pobj	domain,of
R5917	T9117	T9116	compound	TACC,domain
R5918	T9118	T9105	punct	", ",integrated
R5919	T9119	T9120	det	the,members
R592	T994	T985	advmod	close,located
R5920	T9120	T9105	nsubj	members,integrated
R5921	T9121	T9122	advmod	significantly,larger
R5922	T9122	T9120	amod	larger,members
R5923	T9123	T9120	compound	TACC,members
R5924	T9124	T9120	compound	family,members
R5925	T9125	T9120	prep	in,members
R5926	T9126	T9127	amod	higher,protostomes
R5927	T9127	T9125	pobj	protostomes,in
R5928	T9128	T9127	cc	and,protostomes
R5929	T9129	T9127	conj	deuterostomes,protostomes
R593	T995	T994	prep	to,close
R5930	T9130	T9105	aux	may,integrated
R5931	T9131	T9105	aux	have,integrated
R5932	T9132	T9133	nummod	one,functions
R5933	T9133	T9105	dobj	functions,integrated
R5934	T9134	T9132	cc	or,one
R5935	T9135	T9132	conj	more,one
R5936	T9136	T9133	prep	of,functions
R5937	T9137	T9138	det	the,protein
R5938	T9138	T9136	pobj	protein,of
R5939	T9139	T9138	amod	bridging,protein
R594	T996	T997	det	each,other
R5940	T9140	T9138	punct	(,protein
R5941	T9141	T9138	prep	in,protein
R5942	T9142	T9143	det	this,case
R5943	T9143	T9141	pobj	case,in
R5944	T9144	T9138	appos	lin15A,protein
R5945	T9145	T9144	punct	", ",lin15A
R5946	T9146	T9144	conj	lin36,lin15A
R5947	T9147	T9146	cc	or,lin36
R5948	T9148	T9146	conj	lin37,lin36
R5949	T9149	T9105	punct	),integrated
R595	T997	T995	pobj	other,to
R5950	T9150	T9105	punct	.,integrated
R5951	T9152	T9153	nsubj	This,explain
R5952	T9154	T9153	aux	may,explain
R5953	T9155	T9153	advmod	also,explain
R5954	T9156	T9157	det	the,absence
R5955	T9157	T9153	dobj	absence,explain
R5956	T9158	T9157	prep	of,absence
R5957	T9159	T9160	nmod	lin15A,homologues
R5958	T9160	T9158	pobj	homologues,of
R5959	T9161	T9159	punct	", ",lin15A
R596	T998	T956	punct	.,led
R5960	T9162	T9159	conj	lin36,lin15A
R5961	T9163	T9162	cc	and,lin36
R5962	T9164	T9162	conj	lin37,lin36
R5963	T9165	T9157	prep	in,absence
R5964	T9166	T9167	amod	higher,organisms
R5965	T9167	T9165	pobj	organisms,in
R5966	T9168	T9153	punct	", ",explain
R5967	T9169	T9170	mark	as,were
R5968	T9170	T9153	advcl	were,explain
R5969	T9171	T9170	nsubj	they,were
R597	T1000	T1001	advmod	Thus,given
R5970	T9172	T9173	neg	no,longer
R5971	T9173	T9170	advmod	longer,were
R5972	T9174	T9170	prep	under,were
R5973	T9175	T9176	amod	selective,pressure
R5974	T9176	T9174	pobj	pressure,under
R5975	T9177	T9176	amod	evolutionary,pressure
R5976	T9178	T9179	aux	to,remain
R5977	T9179	T9176	acl	remain,pressure
R5978	T9180	T9179	prep	within,remain
R5979	T9181	T9182	det	the,complex
R598	T1002	T1001	punct	", ",given
R5980	T9182	T9180	pobj	complex,within
R5981	T9183	T9170	punct	", ",were
R5982	T9184	T9170	cc	and,were
R5983	T9185	T9186	advmod	thus,lost
R5984	T9186	T9170	conj	lost,were
R5985	T9187	T9186	prep	in,lost
R5986	T9188	T9189	det	the,genome
R5987	T9189	T9187	pobj	genome,in
R5988	T9190	T9189	amod	evolving,genome
R5989	T9191	T9153	punct	.,explain
R599	T1003	T1001	prep	during,given
R5990	T9492	T9493	amod	Proposed,evolution
R5991	T9494	T9493	amod	functional,evolution
R5992	T9495	T9493	prep	of,evolution
R5993	T9496	T9497	det	the,family
R5994	T9497	T9495	pobj	family,of
R5995	T9498	T9497	compound	TACC,family
R5996	T9500	T9501	nsubj	Examination,provides
R5997	T9502	T9500	prep	of,Examination
R5998	T9503	T9504	det	the,evolution
R5999	T9504	T9502	pobj	evolution,of
R600	T1004	T1005	det	the,evolution
R6000	T9505	T9504	prep	of,evolution
R6001	T9506	T9507	amod	ancient,families
R6002	T9507	T9505	pobj	families,of
R6003	T9508	T9507	compound	gene,families
R6004	T9509	T9510	det	an,insight
R6005	T9510	T9501	dobj	insight,provides
R6006	T9511	T9501	prep	into,provides
R6007	T9512	T9513	advmod	how,relates
R6008	T9513	T9511	pcomp	relates,into
R6009	T9514	T9515	compound	gene,structure
R601	T1005	T1003	pobj	evolution,during
R6010	T9515	T9513	nsubj	structure,relates
R6011	T9516	T9513	prep	to,relates
R6012	T9517	T9516	pobj	function,to
R6013	T9518	T9501	punct	.,provides
R6014	T9520	T9521	nsubj	We,presented
R6015	T9522	T9521	aux	have,presented
R6016	T9523	T9521	advmod	above,presented
R6017	T9524	T9521	punct	", ",presented
R6018	T9525	T9526	det	a,examination
R6019	T9526	T9521	dobj	examination,presented
R602	T1006	T1005	prep	of,evolution
R6020	T9527	T9526	amod	detailed,examination
R6021	T9528	T9526	prep	of,examination
R6022	T9529	T9530	nummod	one,family
R6023	T9530	T9528	pobj	family,of
R6024	T9531	T9530	amod	such,family
R6025	T9532	T9530	compound	gene,family
R6026	T9533	T9521	punct	.,presented
R6027	T9535	T9536	det	The,data
R6028	T9536	T9537	nsubj	data,suggest
R6029	T9538	T9539	advmod	so,far
R603	T1007	T1006	pobj	vertebrates,of
R6030	T9539	T9537	advmod	far,suggest
R6031	T9540	T9541	mark	that,has
R6032	T9541	T9537	ccomp	has,suggest
R6033	T9542	T9543	det	the,homologue
R6034	T9543	T9541	nsubj	homologue,has
R6035	T9544	T9543	amod	functional,homologue
R6036	T9545	T9543	compound	TACC,homologue
R6037	T9546	T9543	prep	in,homologue
R6038	T9547	T9546	pobj	yeast,in
R6039	T9548	T9543	punct	(,homologue
R604	T1008	T1001	punct	", ",given
R6040	T9549	T9543	appos	spc72,homologue
R6041	T9550	T9543	punct	),homologue
R6042	T9551	T9552	det	a,role
R6043	T9552	T9541	dobj	role,has
R6044	T9553	T9552	amod	specific,role
R6045	T9554	T9552	prep	in,role
R6046	T9555	T9556	amod	centrosomal,mitotic
R6047	T9556	T9558	amod	mitotic,spindle
R6048	T9557	T9556	punct	/,mitotic
R6049	T9558	T9559	compound	spindle,dynamics
R605	T1009	T1010	amod	subsequent,duplications
R6050	T9559	T9554	pobj	dynamics,in
R6051	T9560	T9561	punct	[,22
R6052	T9561	T9537	parataxis	22,suggest
R6053	T9562	T9561	nummod	21,22
R6054	T9563	T9561	punct	",",22
R6055	T9564	T9561	punct	],22
R6056	T9565	T9537	punct	.,suggest
R6057	T9567	T9568	det	This,function
R6058	T9568	T9571	nsubjpass	function,conserved
R6059	T9569	T9568	amod	ancient,function
R606	T1010	T1001	nsubj	duplications,given
R6060	T9570	T9568	compound	TACC,function
R6061	T9572	T9571	auxpass	is,conserved
R6062	T9573	T9571	prep	throughout,conserved
R6063	T9574	T9573	pobj	evolution,throughout
R6064	T9575	T9571	prep	in,conserved
R6065	T9576	T9577	preconj	both,protostomes
R6066	T9577	T9575	pobj	protostomes,in
R6067	T9578	T9577	cc	and,protostomes
R6068	T9579	T9577	conj	deuterostomes,protostomes
R6069	T9580	T9571	punct	.,conserved
R607	T1011	T1010	amod	successive,duplications
R6070	T9582	T9583	prep	In,appear
R6071	T9584	T9582	pobj	addition,In
R6072	T9585	T9583	punct	", ",appear
R6073	T9586	T9587	det	the,proteins
R6074	T9587	T9583	nsubj	proteins,appear
R6075	T9588	T9587	compound	TACC,proteins
R6076	T9589	T9587	prep	of,proteins
R6077	T9590	T9591	amod	lower,organisms
R6078	T9591	T9589	pobj	organisms,of
R6079	T9592	T9593	aux	to,interact
R608	T1012	T1010	prep	of,duplications
R6080	T9593	T9583	xcomp	interact,appear
R6081	T9594	T9593	prep	with,interact
R6082	T9595	T9596	compound	bridging,proteins
R6083	T9596	T9594	pobj	proteins,with
R6084	T9597	T9598	dep	that,are
R6085	T9598	T9596	relcl	are,proteins
R6086	T9599	T9598	attr	components,are
R6087	T9600	T9599	prep	of,components
R6088	T9601	T9602	amod	several,complexes
R6089	T9602	T9600	pobj	complexes,of
R609	T1013	T1014	det	the,cluster
R6090	T9603	T9602	amod	different,complexes
R6091	T9604	T9602	compound	protein,complexes
R6092	T9605	T9602	acl	involved,complexes
R6093	T9606	T9605	prep	in,involved
R6094	T9607	T9608	compound	DNA,damage
R6095	T9608	T9609	compound	damage,repair
R6096	T9609	T9606	pobj	repair,in
R6097	T9610	T9609	punct	", ",repair
R6098	T9611	T9612	compound	protein,translation
R6099	T9612	T9609	appos	translation,repair
R610	T1014	T1012	pobj	cluster,of
R6100	T9613	T9609	punct	", ",repair
R6101	T9614	T9615	compound	RNA,processing
R6102	T9615	T9609	appos	processing,repair
R6103	T9616	T9615	cc	and,processing
R6104	T9617	T9615	conj	transcription,processing
R6105	T9618	T9583	punct	.,appear
R6106	T9620	T9621	advmod	However,acquired
R6107	T9622	T9621	punct	", ",acquired
R6108	T9623	T9621	prep	over,acquired
R6109	T9624	T9625	det	the,process
R611	T1015	T1014	amod	ancestral,cluster
R6110	T9625	T9623	pobj	process,over
R6111	T9626	T9625	prep	of,process
R6112	T9627	T9628	amod	evolutionary,time
R6113	T9628	T9626	pobj	time,of
R6114	T9629	T9621	punct	", ",acquired
R6115	T9630	T9621	prep	with,acquired
R6116	T9631	T9632	det	the,acquisition
R6117	T9632	T9630	pobj	acquisition,with
R6118	T9633	T9632	prep	of,acquisition
R6119	T9634	T9635	amod	new,domains
R612	T1016	T1014	compound	gene,cluster
R6120	T9635	T9633	pobj	domains,of
R6121	T9636	T9635	cc	and,domains
R6122	T9637	T9635	conj	duplication,domains
R6123	T9638	T9637	prep	of,duplication
R6124	T9639	T9640	det	the,precursor
R6125	T9640	T9638	pobj	precursor,of
R6126	T9641	T9640	compound	chordate,precursor
R6127	T9642	T9640	compound	TACC,precursor
R6128	T9643	T9621	punct	", ",acquired
R6129	T9644	T9645	det	the,proteins
R613	T1017	T1001	aux	have,given
R6130	T9645	T9621	nsubj	proteins,acquired
R6131	T9646	T9645	compound	chordate,proteins
R6132	T9647	T9645	compound	TACC,proteins
R6133	T9648	T9621	aux	have,acquired
R6134	T9649	T9650	det	the,ability
R6135	T9650	T9621	dobj	ability,acquired
R6136	T9651	T9652	aux	to,interact
R6137	T9652	T9650	acl	interact,ability
R6138	T9653	T9652	advmod	directly,interact
R6139	T9654	T9652	prep	with,interact
R614	T1018	T1001	dobj	rise,given
R6140	T9655	T9654	pobj	some,with
R6141	T9656	T9655	prep	of,some
R6142	T9657	T9658	det	the,components
R6143	T9658	T9656	pobj	components,of
R6144	T9659	T9658	amod	other,components
R6145	T9660	T9658	prep	of,components
R6146	T9661	T9662	det	these,complexes
R6147	T9662	T9660	pobj	complexes,of
R6148	T9663	T9655	punct	(,some
R6149	T9664	T9665	amod	such,as
R615	T1019	T1001	prep	to,given
R6150	T9665	T9655	prep	as,some
R6151	T9666	T9667	det	the,proteins
R6152	T9667	T9665	pobj	proteins,as
R6153	T9668	T9667	compound	LSm,proteins
R6154	T9669	T9667	punct	", ",proteins
R6155	T9670	T9671	amod	nuclear,receptors
R6156	T9671	T9667	conj	receptors,proteins
R6157	T9672	T9671	compound	hormone,receptors
R6158	T9673	T9671	punct	", ",receptors
R6159	T9674	T9671	conj	GAS41,receptors
R616	T1020	T1021	nummod	three,members
R6160	T9675	T9674	punct	", ",GAS41
R6161	T9676	T9677	amod	accessory,proteins
R6162	T9677	T9674	conj	proteins,GAS41
R6163	T9678	T9677	cc	and,proteins
R6164	T9679	T9680	compound	transcription,factors
R6165	T9680	T9677	conj	factors,proteins
R6166	T9681	T9655	punct	),some
R6167	T9682	T9621	punct	", ",acquired
R6168	T9683	T9621	cc	and,acquired
R6169	T9684	T9685	advmod	thus,evolved
R617	T1021	T1019	pobj	members,to
R6170	T9685	T9621	conj	evolved,acquired
R6171	T9686	T9687	amod	additional,functions
R6172	T9687	T9685	dobj	functions,evolved
R6173	T9688	T9685	prep	within,evolved
R6174	T9689	T9690	det	these,complexes
R6175	T9690	T9688	pobj	complexes,within
R6176	T9691	T9621	punct	.,acquired
R6177	T9693	T9694	advmod	Indeed,was
R6178	T9695	T9694	punct	", ",was
R6179	T9696	T9697	det	the,function
R618	T1022	T1021	compound	TACC,members
R6180	T9697	T9694	nsubj	function,was
R6181	T9698	T9697	amod	first,function
R6182	T9699	T9697	amod	assigned,function
R6183	T9700	T9697	prep	of,function
R6184	T9701	T9702	det	a,protein
R6185	T9702	T9700	pobj	protein,of
R6186	T9703	T9702	compound	vertebrate,protein
R6187	T9704	T9702	compound	TACC,protein
R6188	T9705	T9702	punct	", ",protein
R6189	T9706	T9707	compound	mouse,TACC3
R619	T1023	T1021	compound	family,members
R6190	T9707	T9702	appos	TACC3,protein
R6191	T9708	T9694	punct	", ",was
R6192	T9709	T9694	prep	as,was
R6193	T9710	T9711	det	a,coactivator
R6194	T9711	T9709	pobj	coactivator,as
R6195	T9712	T9711	amod	transcriptional,coactivator
R6196	T9713	T9711	prep	of,coactivator
R6197	T9714	T9715	det	the,response
R6198	T9715	T9713	pobj	response,of
R6199	T9716	T9717	npadvmod	ARNT,mediated
R620	T1024	T1021	acl	located,members
R6200	T9717	T9715	amod	mediated,response
R6201	T9718	T9715	amod	transcriptional,response
R6202	T9719	T9715	prep	to,response
R6203	T9720	T9719	pobj	hypoxia,to
R6204	T9721	T9720	cc	and,hypoxia
R6205	T9722	T9723	amod	polyaromatic,hydrocarbons
R6206	T9723	T9720	conj	hydrocarbons,hypoxia
R6207	T9724	T9725	punct	[,7
R6208	T9725	T9694	parataxis	7,was
R6209	T9726	T9725	punct	],7
R621	T1025	T1024	advmod	close,located
R6210	T9727	T9694	punct	.,was
R6211	T9729	T9730	compound	Mouse,TACC3
R6212	T9730	T9731	nsubjpass	TACC3,reported
R6213	T9732	T9731	aux	has,reported
R6214	T9733	T9731	advmod	also,reported
R6215	T9734	T9731	auxpass	been,reported
R6216	T9735	T9736	aux	to,interact
R6217	T9736	T9731	xcomp	interact,reported
R6218	T9737	T9736	prep	with,interact
R6219	T9738	T9739	det	the,STAT5
R622	T1026	T1025	prep	to,close
R6220	T9739	T9737	pobj	STAT5,with
R6221	T9740	T9739	compound	transcription,STAT5
R6222	T9741	T9739	compound	factor,STAT5
R6223	T9742	T9743	punct	[,33
R6224	T9743	T9731	parataxis	33,reported
R6225	T9744	T9743	punct	],33
R6226	T9745	T9731	punct	.,reported
R6227	T9747	T9748	advmod	Recently,demonstrated
R6228	T9749	T9748	punct	", ",demonstrated
R6229	T9750	T9748	nsubj	we,demonstrated
R623	T1027	T1028	compound	FGFR,genes
R6230	T9751	T9748	aux	have,demonstrated
R6231	T9752	T9753	mark	that,bind
R6232	T9753	T9748	ccomp	bind,demonstrated
R6233	T9754	T9753	nsubj	TACC2,bind
R6234	T9755	T9754	cc	and,TACC2
R6235	T9756	T9754	conj	TACC3,TACC2
R6236	T9757	T9753	aux	can,bind
R6237	T9758	T9753	prep	to,bind
R6238	T9759	T9760	amod	nuclear,acetyltransferases
R6239	T9760	T9758	pobj	acetyltransferases,to
R624	T1028	T1026	pobj	genes,to
R6240	T9761	T9760	compound	histone,acetyltransferases
R6241	T9762	T9763	punct	[,34
R6242	T9763	T9748	parataxis	34,demonstrated
R6243	T9764	T9763	punct	],34
R6244	T9765	T9748	punct	", ",demonstrated
R6245	T9766	T9767	advmod	further,confirming
R6246	T9767	T9748	advcl	confirming,demonstrated
R6247	T9768	T9769	det	a,role
R6248	T9769	T9767	dobj	role,confirming
R6249	T9770	T9771	advmod	more,direct
R625	T1029	T1024	prep	in,located
R6250	T9771	T9769	amod	direct,role
R6251	T9772	T9769	prep	for,role
R6252	T9773	T9774	det	the,proteins
R6253	T9774	T9772	pobj	proteins,for
R6254	T9775	T9774	compound	TACC,proteins
R6255	T9776	T9769	prep	in,role
R6256	T9777	T9778	amod	transcriptional,events
R6257	T9778	T9776	pobj	events,in
R6258	T9779	T9777	cc	and,transcriptional
R6259	T9780	T9781	compound	chromatin,remodeling
R626	T1030	T1029	pobj	humans,in
R6260	T9781	T9777	conj	remodeling,transcriptional
R6261	T9782	T9748	punct	.,demonstrated
R6262	T9784	T9785	advmod	Interestingly,interact
R6263	T9786	T9787	mark	although,interact
R6264	T9787	T9785	advcl	interact,interact
R6265	T9788	T9789	det	all,proteins
R6266	T9789	T9787	nsubj	proteins,interact
R6267	T9790	T9789	amod	human,proteins
R6268	T9791	T9789	compound	TACC,proteins
R6269	T9792	T9787	aux	can,interact
R627	T1031	T1001	punct	.,given
R6270	T9793	T9787	advmod	directly,interact
R6271	T9794	T9787	prep	with,interact
R6272	T9795	T9796	det	the,acetyltransferase
R6273	T9796	T9794	pobj	acetyltransferase,with
R6274	T9797	T9796	compound	histone,acetyltransferase
R6275	T9798	T9796	appos	pCAF,acetyltransferase
R6276	T9799	T9800	advmod	in,vitro
R6277	T9800	T9787	advmod	vitro,interact
R6278	T9801	T9785	punct	", ",interact
R6279	T9802	T9803	det	the,isoforms
R628	T1033	T1034	prep	In,is
R6280	T9803	T9785	nsubj	isoforms,interact
R6281	T9804	T9803	compound	TACC1,isoforms
R6282	T9805	T9803	acl	expressed,isoforms
R6283	T9806	T9805	prep	in,expressed
R6284	T9807	T9808	amod	human,cells
R6285	T9808	T9806	pobj	cells,in
R6286	T9809	T9810	compound	breast,cancer
R6287	T9810	T9808	compound	cancer,cells
R6288	T9811	T9785	aux	do,interact
R6289	T9812	T9785	neg	not,interact
R629	T1035	T1033	pobj	accordance,In
R6290	T9813	T9785	prep	with,interact
R6291	T9814	T9815	det	this,acetylase
R6292	T9815	T9813	pobj	acetylase,with
R6293	T9816	T9815	compound	histone,acetylase
R6294	T9817	T9818	punct	[,34
R6295	T9818	T9785	parataxis	34,interact
R6296	T9819	T9818	punct	],34
R6297	T9820	T9785	punct	.,interact
R6298	T9822	T9823	nsubj	This,be
R6299	T9824	T9823	aux	may,be
R630	T1036	T1035	prep	with,accordance
R6300	T9825	T9823	acomp	attributable,be
R6301	T9826	T9825	prep	to,attributable
R6302	T9827	T9828	det	the,function
R6303	T9828	T9826	pobj	function,to
R6304	T9829	T9828	amod	proposed,function
R6305	T9830	T9828	prep	of,function
R6306	T9831	T9832	det	the,variants
R6307	T9832	T9830	pobj	variants,of
R6308	T9833	T9834	npadvmod	Exon,containing
R6309	T9834	T9832	amod	containing,variants
R631	T1037	T1038	det	the,quadruplication
R6310	T9835	T9833	nummod	1,Exon
R6311	T9836	T9832	compound	TACC1,variants
R6312	T9837	T9832	prep	in,variants
R6313	T9838	T9839	compound	RNA,processing
R6314	T9839	T9837	pobj	processing,in
R6315	T9840	T9823	punct	", ",be
R6316	T9841	T9823	prep	via,be
R6317	T9842	T9843	det	the,interaction
R6318	T9843	T9841	pobj	interaction,via
R6319	T9844	T9843	prep	with,interaction
R632	T1038	T1036	pobj	quadruplication,with
R6320	T9845	T9844	pobj	LSm,with
R6321	T9846	T9845	punct	-,LSm
R6322	T9847	T9845	nummod	7,LSm
R6323	T9848	T9845	cc	and,LSm
R6324	T9849	T9845	conj	SmG,LSm
R6325	T9850	T9851	punct	[,19
R6326	T9851	T9823	parataxis	19,be
R6327	T9852	T9851	punct	],19
R6328	T9853	T9823	punct	.,be
R6329	T9855	T9856	advmod	Thus,adds
R633	T1039	T1038	amod	proposed,quadruplication
R6330	T9857	T9856	punct	", ",adds
R6331	T9858	T9859	amod	alternative,splicing
R6332	T9859	T9856	nsubj	splicing,adds
R6333	T9860	T9859	prep	of,splicing
R6334	T9861	T9862	det	the,gene
R6335	T9862	T9860	pobj	gene,of
R6336	T9863	T9862	compound	TACC1,gene
R6337	T9864	T9865	amod	further,diversity
R6338	T9865	T9856	dobj	diversity,adds
R6339	T9866	T9856	prep	to,adds
R634	T1040	T1038	prep	of,quadruplication
R6340	T9867	T9868	compound	TACC1,function
R6341	T9868	T9866	pobj	function,to
R6342	T9869	T9856	punct	", ",adds
R6343	T9870	T9871	mark	as,change
R6344	T9871	T9856	advcl	change,adds
R6345	T9872	T9873	det	the,deletion
R6346	T9873	T9871	nsubj	deletion,change
R6347	T9874	T9873	prep	of,deletion
R6348	T9875	T9876	amod	specific,exons
R6349	T9876	T9874	pobj	exons,of
R635	T1041	T1042	det	the,genome
R6350	T9877	T9876	cc	and,exons
R6351	T9878	T9879	poss	their,domains
R6352	T9879	T9876	conj	domains,exons
R6353	T9880	T9879	amod	associated,domains
R6354	T9881	T9879	compound	binding,domains
R6355	T9882	T9871	aux	will,change
R6356	T9883	T9884	det	the,complexes
R6357	T9884	T9871	dobj	complexes,change
R6358	T9885	T9884	amod	potential,complexes
R6359	T9886	T9884	compound	protein,complexes
R636	T1042	T1040	pobj	genome,of
R6360	T9887	T9888	prep	with,associate
R6361	T9888	T9884	relcl	associate,complexes
R6362	T9889	T9887	pobj	which,with
R6363	T9890	T9888	nsubj	they,associate
R6364	T9891	T9888	aux	can,associate
R6365	T9892	T9871	punct	", ",change
R6366	T9893	T9894	preconj	either,by
R6367	T9894	T9871	prep	by,change
R6368	T9895	T9894	advmod	directly,by
R6369	T9896	T9894	punct	", ",by
R637	T1043	T1042	compound	vertebrate,genome
R6370	T9897	T9894	cc	or,by
R6371	T9898	T9894	pcomp	redirecting,by
R6372	T9899	T9900	det	the,variants
R6373	T9900	T9898	dobj	variants,redirecting
R6374	T9901	T9900	compound	splice,variants
R6375	T9902	T9898	prep	to,redirecting
R6376	T9903	T9904	amod	different,compartments
R6377	T9904	T9902	pobj	compartments,to
R6378	T9905	T9904	amod	subcellular,compartments
R6379	T9906	T9856	punct	.,adds
R638	T1044	T1038	prep	during,quadruplication
R6380	T9908	T9909	prep	With,is
R6381	T9910	T9911	det	the,duplication
R6382	T9911	T9908	pobj	duplication,With
R6383	T9912	T9911	prep	of,duplication
R6384	T9913	T9914	det	the,ancestor
R6385	T9914	T9912	pobj	ancestor,of
R6386	T9915	T9916	compound	TACC1,TACC2
R6387	T9916	T9914	compound	TACC2,ancestor
R6388	T9917	T9916	punct	/,TACC2
R6389	T9918	T9909	punct	", ",is
R639	T1045	T1044	pobj	evolution,during
R6390	T9919	T9909	nsubj	it,is
R6391	T9920	T9909	acomp	apparent,is
R6392	T9921	T9922	mark	that,introduced
R6393	T9922	T9909	ccomp	introduced,is
R6394	T9923	T9924	det	an,diversity
R6395	T9924	T9922	nsubjpass	diversity,introduced
R6396	T9925	T9926	advmod	even,greater
R6397	T9926	T9924	amod	greater,diversity
R6398	T9927	T9924	amod	functional,diversity
R6399	T9928	T9922	aux	may,introduced
R640	T1046	T1034	punct	", ",is
R6400	T9929	T9922	aux	have,introduced
R6401	T9930	T9922	auxpass	been,introduced
R6402	T9931	T9922	prep	into,introduced
R6403	T9932	T9933	det	the,family
R6404	T9933	T9931	pobj	family,into
R6405	T9934	T9933	compound	TACC,family
R6406	T9935	T9909	punct	.,is
R6407	T9937	T9938	det	The,protein
R6408	T9938	T9940	nsubj	protein,retains
R6409	T9939	T9938	compound	TACC2,protein
R641	T1047	T1034	expl	there,is
R6410	T9941	T9942	det	the,ability
R6411	T9942	T9940	dobj	ability,retains
R6412	T9943	T9942	prep	of,ability
R6413	T9944	T9943	pobj	TACC3,of
R6414	T9945	T9946	aux	to,interact
R6415	T9946	T9942	acl	interact,ability
R6416	T9947	T9946	prep	with,interact
R6417	T9948	T9947	pobj	GAS41,with
R6418	T9949	T9948	punct	", ",GAS41
R6419	T9950	T9948	conj	INI1,GAS41
R642	T1048	T1049	det	a,member
R6420	T9951	T9950	punct	", ",INI1
R6421	T9952	T9953	compound	histone,acetyltransferases
R6422	T9953	T9950	conj	acetyltransferases,INI1
R6423	T9954	T9953	cc	and,acetyltransferases
R6424	T9955	T9956	compound	transcription,factors
R6425	T9956	T9953	conj	factors,acetyltransferases
R6426	T9957	T9956	punct	(,factors
R6427	T9958	T9959	prep	in,RXRβ
R6428	T9959	T9956	appos	RXRβ,factors
R6429	T9960	T9961	det	this,case
R643	T1049	T1034	attr	member,is
R6430	T9961	T9958	pobj	case,in
R6431	T9962	T9959	punct	", ",RXRβ
R6432	T9963	T9956	punct	),factors
R6433	T9964	T9965	punct	(,Fig.
R6434	T9965	T9946	parataxis	Fig.,interact
R6435	T9966	T9965	nummod	7,Fig.
R6436	T9967	T9965	punct	),Fig.
R6437	T9968	T9969	punct	[,34
R6438	T9969	T9946	parataxis	34,interact
R6439	T9970	T9969	nummod	3,34
R644	T1050	T1049	amod	fourth,member
R6440	T9971	T9969	punct	",",34
R6441	T9972	T9969	punct	],34
R6442	T9973	T9940	punct	.,retains
R6443	T9975	T9976	advmod	However,indicates
R6444	T9977	T9976	punct	", ",indicates
R6445	T9978	T9979	det	the,splicing
R6446	T9979	T9976	nsubj	splicing,indicates
R6447	T9980	T9981	npadvmod	tissue,specific
R6448	T9981	T9979	amod	specific,splicing
R6449	T9982	T9979	prep	of,splicing
R645	T1051	T1049	compound	FGFR,member
R6450	T9983	T9984	det	the,exon
R6451	T9984	T9982	pobj	exon,of
R6452	T9985	T9986	nummod	5,kb
R6453	T9986	T9984	compound	kb,exon
R6454	T9987	T9984	prep	in,exon
R6455	T9988	T9989	det	the,isoform
R6456	T9989	T9987	pobj	isoform,in
R6457	T9990	T9989	compound	TACC2l,isoform
R6458	T9991	T9992	punct	[,3
R6459	T9992	T9979	parataxis	3,splicing
R646	T1052	T1049	compound	family,member
R6460	T9993	T9992	punct	],3
R6461	T9994	T9995	mark	that,has
R6462	T9995	T9976	ccomp	has,indicates
R6463	T9996	T9997	det	this,protein
R6464	T9997	T9995	nsubj	protein,has
R6465	T9998	T9999	amod	several,functions
R6466	T9999	T9995	dobj	functions,has
R6467	T10000	T9999	amod	temporal,functions
R6468	T10001	T10000	cc	and,temporal
R6469	T10002	T10003	npadvmod	tissue,specific
R647	T1053	T1034	prep	in,is
R6470	T10003	T10000	conj	specific,temporal
R6471	T10004	T10005	advmod	yet,identified
R6472	T10005	T9999	advcl	identified,functions
R6473	T10006	T10005	aux	to,identified
R6474	T10007	T10005	auxpass	be,identified
R6475	T10008	T9976	punct	.,indicates
R6478	T10099	T10098	cc	and,Compilation
R6479	T10100	T10098	conj	assembly,Compilation
R648	T1054	T1053	pobj	vertebrates,in
R6480	T10101	T10098	prep	of,Compilation
R6481	T10102	T10103	advmod	previously,uncharacterized
R6482	T10103	T10104	amod	uncharacterized,cDNAs
R6483	T10104	T10101	pobj	cDNAs,of
R6484	T10105	T10104	compound	TACC,cDNAs
R6485	T10106	T10104	cc	and,cDNAs
R6486	T10107	T10104	conj	genes,cDNAs
R6487	T10109	T10110	amod	Corresponding,sequences
R6488	T10110	T10112	nsubjpass	sequences,identified
R6489	T10111	T10110	amod	orthologous,sequences
R649	T1055	T1034	punct	", ",is
R6490	T10113	T10110	prep	for,sequences
R6491	T10114	T10115	nmod	TACC,families
R6492	T10115	T10113	pobj	families,for
R6493	T10116	T10114	punct	", ",TACC
R6494	T10117	T10114	conj	RHAMM,TACC
R6495	T10118	T10117	punct	", ",RHAMM
R6496	T10119	T10117	conj	KLP,RHAMM
R6497	T10120	T10119	punct	", ",KLP
R6498	T10121	T10119	conj	KIF,KLP
R6499	T10122	T10121	punct	", ",KIF
R650	T1056	T1034	advcl	raising,is
R6500	T10123	T10121	conj	TPM,KIF
R6501	T10124	T10123	cc	and,TPM
R6502	T10125	T10123	conj	keratins,TPM
R6503	T10126	T10112	auxpass	were,identified
R6504	T10127	T10112	advmod	initially,identified
R6505	T10128	T10112	advcl	using,identified
R6506	T10129	T10130	det	the,program
R6507	T10130	T10128	dobj	program,using
R6508	T10131	T10130	compound	TBLASTN,program
R6509	T10132	T10133	punct	[,36
R651	T1057	T1058	det	the,question
R6510	T10133	T10128	parataxis	36,using
R6511	T10134	T10133	punct	],36
R6512	T10135	T10136	aux	to,search
R6513	T10136	T10128	advcl	search,using
R6514	T10137	T10138	det	the,databases
R6515	T10138	T10136	dobj	databases,search
R6516	T10139	T10138	amod	published,databases
R6517	T10140	T10138	amod	genomic,databases
R6518	T10141	T10140	cc	and,genomic
R6519	T10142	T10140	conj	cDNA,genomic
R652	T1058	T1056	dobj	question,raising
R6520	T10143	T10112	punct	.,identified
R6521	T10145	T10146	prep	For,produced
R6522	T10147	T10148	compound	Takifugu,rubripes
R6523	T10148	T10145	pobj	rubripes,For
R6524	T10149	T10146	punct	", ",produced
R6525	T10150	T10151	compound	gene,predictions
R6526	T10151	T10146	nsubjpass	predictions,produced
R6527	T10152	T10146	auxpass	were,produced
R6528	T10153	T10146	agent	by,produced
R6529	T10154	T10155	det	the,pipeline
R653	T1059	T1058	prep	of,question
R6530	T10155	T10153	pobj	pipeline,by
R6531	T10156	T10155	nmod	Ensembl,pipeline
R6532	T10157	T10155	amod	automated,pipeline
R6533	T10158	T10159	punct	[,37
R6534	T10159	T10155	parataxis	37,pipeline
R6535	T10160	T10159	punct	],37
R6536	T10161	T10155	cc	and,pipeline
R6537	T10162	T10163	det	the,server
R6538	T10163	T10155	conj	server,pipeline
R6539	T10164	T10163	compound	JGI,server
R654	T1060	T1061	mark	whether,associated
R6540	T10165	T10163	compound	blast,server
R6541	T10166	T10146	punct	.,produced
R6542	T10168	T10169	compound	DNA,sequences
R6543	T10169	T10170	nsubj	sequences,extracted
R6544	T10171	T10169	acl	covering,sequences
R6545	T10172	T10173	det	the,regions
R6546	T10173	T10171	dobj	regions,covering
R6547	T10174	T10173	compound	homology,regions
R6548	T10175	T10170	aux	were,extracted
R6549	T10176	T10170	cc	and,extracted
R655	T1061	T1059	pcomp	associated,of
R6550	T10177	T10170	conj	analyzed,extracted
R6551	T10178	T10177	prep	by,analyzed
R6552	T10179	T10178	pobj	Genscan,by
R6553	T10180	T10181	aux	to,obtain
R6554	T10181	T10170	advcl	obtain,extracted
R6555	T10182	T10183	amod	potential,exons
R6556	T10183	T10181	dobj	exons,obtain
R6557	T10184	T10170	punct	.,extracted
R6558	T10186	T10187	prep	In,added
R6559	T10188	T10189	det	some,cases
R656	T1062	T1063	det	a,gene
R6560	T10189	T10186	pobj	cases,In
R6561	T10190	T10187	punct	", ",added
R6562	T10191	T10187	nsubjpass	exons,added
R6563	T10192	T10187	auxpass	were,added
R6564	T10193	T10187	cc	or,added
R6565	T10194	T10187	conj	modified,added
R6566	T10195	T10194	prep	based,modified
R6567	T10196	T10195	prep	on,based
R6568	T10197	T10198	det	the,similarity
R6569	T10198	T10196	pobj	similarity,on
R657	T1063	T1061	nsubjpass	gene,associated
R6570	T10199	T10198	amod	best,similarity
R6571	T10200	T10198	prep	of,similarity
R6572	T10201	T10202	amod	translated,peptides
R6573	T10202	T10200	pobj	peptides,of
R6574	T10203	T10198	prep	to,similarity
R6575	T10204	T10205	det	the,proteins
R6576	T10205	T10203	pobj	proteins,to
R6577	T10206	T10205	amod	corresponding,proteins
R6578	T10207	T10205	nmod	mouse,proteins
R6579	T10208	T10207	cc	and,mouse
R658	T1064	T1063	amod	fourth,gene
R6580	T10209	T10207	conj	human,mouse
R6581	T10210	T10187	punct	.,added
R6582	T10212	T10213	prep	For,used
R6583	T10214	T10212	pobj	regions,For
R6584	T10215	T10214	prep	with,regions
R6585	T10216	T10217	amod	low,similarity
R6586	T10217	T10215	pobj	similarity,with
R6587	T10218	T10217	compound	sequence,similarity
R6588	T10219	T10213	punct	", ",used
R6589	T10220	T10221	amod	genomic,sequences
R659	T1065	T1063	compound	TACC,gene
R6590	T10221	T10213	nsubjpass	sequences,used
R6591	T10222	T10221	prep	from,sequences
R6592	T10223	T10224	det	the,pufferfish
R6593	T10224	T10222	pobj	pufferfish,from
R6594	T10225	T10226	amod	fresh,water
R6595	T10226	T10224	compound	water,pufferfish
R6596	T10227	T10224	punct	", ",pufferfish
R6597	T10228	T10229	compound	Tetraodon,nigroviridis
R6598	T10229	T10224	appos	nigroviridis,pufferfish
R6599	T10230	T10213	auxpass	were,used
R660	T1066	T1061	auxpass	is,associated
R6600	T10231	T10213	prep	as,used
R6601	T10232	T10233	amod	additional,means
R6602	T10233	T10231	pobj	means,as
R6603	T10234	T10235	aux	to,verify
R6604	T10235	T10233	advcl	verify,means
R6605	T10236	T10237	det	the,exons
R6606	T10237	T10235	dobj	exons,verify
R6607	T10238	T10237	amod	predicted,exons
R6608	T10239	T10213	punct	.,used
R6609	T10241	T10242	prep	Due,obtained
R661	T1067	T1061	prep	with,associated
R6610	T10243	T10241	pcomp	to,Due
R6611	T10244	T10245	det	the,variability
R6612	T10245	T10241	pobj	variability,Due
R6613	T10246	T10245	prep	of,variability
R6614	T10247	T10248	det	the,region
R6615	T10248	T10246	pobj	region,of
R6616	T10249	T10248	amod	central,region
R6617	T10250	T10248	prep	of,region
R6618	T10251	T10252	compound	vertebrate,cDNAs
R6619	T10252	T10250	pobj	cDNAs,of
R662	T1068	T1067	pobj	FGFR4,with
R6620	T10253	T10252	compound	TACC3,cDNAs
R6621	T10254	T10255	punct	(,see
R6622	T10255	T10245	parataxis	see,variability
R6623	T10256	T10255	dobj	text,see
R6624	T10257	T10255	punct	),see
R6625	T10258	T10242	punct	", ",obtained
R6626	T10259	T10260	aux	to,confirm
R6627	T10260	T10242	advcl	confirm,obtained
R6628	T10261	T10260	advmod	further,confirm
R6629	T10262	T10260	dobj	prediction,confirm
R663	T1069	T1061	prep	in,associated
R6630	T10263	T10262	prep	of,prediction
R6631	T10264	T10265	det	the,rubripes
R6632	T10265	T10263	pobj	rubripes,of
R6633	T10266	T10265	compound	Takifugu,rubripes
R6634	T10267	T10265	appos	TACC3,rubripes
R6635	T10268	T10242	punct	", ",obtained
R6636	T10269	T10270	amod	full,length
R6637	T10270	T10271	compound	length,cDNAs
R6638	T10271	T10242	nsubjpass	cDNAs,obtained
R6639	T10272	T10271	acl	corresponding,cDNAs
R664	T1070	T1071	compound	vertebrate,genomes
R6640	T10273	T10272	prep	to,corresponding
R6641	T10274	T10275	det	the,TACC3
R6642	T10275	T10273	pobj	TACC3,to
R6643	T10276	T10275	compound	Danio,TACC3
R6644	T10277	T10275	compound	rerio,TACC3
R6645	T10278	T10279	punct	(,2639991
R6646	T10279	T10275	parataxis	2639991,TACC3
R6647	T10280	T10279	nmod	IMAGE,2639991
R6648	T10281	T10279	nmod	clones,2639991
R6649	T10282	T10279	punct	", ",2639991
R665	T1071	T1069	pobj	genomes,in
R6650	T10283	T10279	conj	2640369,2639991
R6651	T10284	T10283	cc	and,2640369
R6652	T10285	T10283	conj	3724452,2640369
R6653	T10286	T10279	punct	),2639991
R6654	T10287	T10242	auxpass	were,obtained
R6655	T10288	T10242	advmod	also,obtained
R6656	T10289	T10242	prep	from,obtained
R6657	T10290	T10289	pobj	A.T.C.C.,from
R6658	T10291	T10242	cc	and,obtained
R6659	T10292	T10293	advmod	fully,sequenced
R666	T1072	T1034	punct	.,is
R6660	T10293	T10242	conj	sequenced,obtained
R6661	T10294	T10242	punct	.,obtained
R6662	T10296	T10297	amod	Potential,segments
R6663	T10297	T10300	nsubjpass	segments,identified
R6664	T10298	T10297	amod	paralogous,segments
R6665	T10299	T10297	amod	chromosomal,segments
R6666	T10301	T10297	cc	and,segments
R6667	T10302	T10297	conj	scaffold,segments
R6668	T10303	T10300	auxpass	were,identified
R6669	T10304	T10300	prep	by,identified
R667	T1074	T1075	prep	To,one
R6670	T10305	T10304	pcomp	searching,by
R6671	T10306	T10307	det	the,databases
R6672	T10307	T10305	dobj	databases,searching
R6673	T10308	T10307	amod	public,databases
R6674	T10309	T10307	acl	deposited,databases
R6675	T10310	T10309	prep	at,deposited
R6676	T10311	T10310	pobj	NCBI,at
R6677	T10312	T10310	cc	and,at
R6678	T10313	T10310	conj	at,at
R6679	T10314	T10315	det	the,Project
R668	T1076	T1074	pobj	date,To
R6680	T10315	T10313	pobj	Project,at
R6681	T10316	T10317	compound	Human,Genome
R6682	T10317	T10315	compound	Genome,Project
R6683	T10318	T10315	compound	Mapping,Project
R6684	T10319	T10315	punct	", ",Project
R6685	T10320	T10315	npadvmod	Cambridge,Project
R6686	T10321	T10320	npadvmod	UK,Cambridge
R6687	T10322	T10300	punct	.,identified
R6688	T10440	T10439	prep	of,Cloning
R6689	T10441	T10442	compound	vertebrate,TACC
R669	T1077	T1075	punct	", ",one
R6690	T10442	T10443	compound	TACC,cDNAs
R6691	T10443	T10440	pobj	cDNAs,of
R6692	T10445	T10446	det	The,TACC3
R6693	T10446	T10448	nsubjpass	TACC3,cloned
R6694	T10447	T10446	compound	rabbit,TACC3
R6695	T10449	T10448	auxpass	was,cloned
R6696	T10450	T10448	prep	by,cloned
R6697	T10451	T10452	compound	rt,PCR
R6698	T10452	T10450	pobj	PCR,by
R6699	T10453	T10452	punct	-,PCR
R670	T1078	T1079	advmod	only,genes
R6700	T10454	T10448	advcl	using,cloned
R6701	T10455	T10456	det	the,primer
R6702	T10456	T10454	dobj	primer,using
R6703	T10457	T10458	punct	"""",specific
R6704	T10458	T10456	amod	specific,primer
R6705	T10459	T10458	npadvmod	TACC4,specific
R6706	T10460	T10458	punct	"""",specific
R6707	T10461	T10456	appos	T4RACE2,primer
R6708	T10462	T10463	punct	[,9
R6709	T10463	T10456	parataxis	9,primer
R671	T1079	T1083	nsubjpass	genes,cloned
R6710	T10464	T10463	punct	],9
R6711	T10465	T10466	punct	(,cccgaactgctccaggtaatcgatctc
R6712	T10466	T10456	parataxis	cccgaactgctccaggtaatcgatctc,primer
R6713	T10467	T10466	nummod	5,cccgaactgctccaggtaatcgatctc
R6714	T10468	T10467	punct	',5
R6715	T10469	T10466	punct	-,cccgaactgctccaggtaatcgatctc
R6716	T10470	T10466	punct	-,cccgaactgctccaggtaatcgatctc
R6717	T10471	T10466	nummod	3,cccgaactgctccaggtaatcgatctc
R6718	T10472	T10466	punct	',cccgaactgctccaggtaatcgatctc
R6719	T10473	T10466	punct	),cccgaactgctccaggtaatcgatctc
R672	T1080	T1079	nummod	three,genes
R6720	T10474	T10456	cc	and,primer
R6721	T10475	T10476	det	a,primer
R6722	T10476	T10456	conj	primer,primer
R6723	T10477	T10476	compound	consensus,primer
R6724	T10478	T10476	punct	", ",primer
R6725	T10479	T10476	appos	T3con2,primer
R6726	T10480	T10476	punct	", ",primer
R6727	T10481	T10476	acl	designed,primer
R6728	T10482	T10481	prep	to,designed
R6729	T10483	T10484	det	the,region
R673	T1081	T1079	amod	active,genes
R6730	T10484	T10482	pobj	region,to
R6731	T10485	T10484	acl	encompassing,region
R6732	T10486	T10487	det	the,initiator
R6733	T10487	T10485	dobj	initiator,encompassing
R6734	T10488	T10487	compound	vertebrate,initiator
R6735	T10489	T10487	compound	TACC3,initiator
R6736	T10490	T10487	appos	methionine,initiator
R6737	T10491	T10492	punct	(,tatgagtctgcaggtcttaaacgac
R6738	T10492	T10487	parataxis	tatgagtctgcaggtcttaaacgac,initiator
R6739	T10493	T10492	nummod	5,tatgagtctgcaggtcttaaacgac
R674	T1082	T1079	compound	TACC,genes
R6740	T10494	T10493	punct	',5
R6741	T10495	T10492	punct	-,tatgagtctgcaggtcttaaacgac
R6742	T10496	T10492	punct	-,tatgagtctgcaggtcttaaacgac
R6743	T10497	T10492	nummod	3,tatgagtctgcaggtcttaaacgac
R6744	T10498	T10492	punct	',tatgagtctgcaggtcttaaacgac
R6745	T10499	T10492	punct	),tatgagtctgcaggtcttaaacgac
R6746	T10500	T10448	punct	.,cloned
R6747	T10502	T10503	prep	For,based
R6748	T10504	T10502	pcomp	cloning,For
R6749	T10505	T10506	det	the,cDNA
R675	T1083	T1075	ccomp	cloned,one
R6750	T10506	T10504	dobj	cDNA,cloning
R6751	T10507	T10508	compound	mouse,Tacc1X
R6752	T10508	T10506	compound	Tacc1X,cDNA
R6753	T10509	T10503	punct	", ",based
R6754	T10510	T10511	det	the,primers
R6755	T10511	T10503	nsubjpass	primers,based
R6756	T10512	T10511	acl	used,primers
R6757	T10513	T10503	auxpass	were,based
R6758	T10514	T10503	prep	upon,based
R6759	T10515	T10516	det	the,sequence
R676	T1084	T1083	aux	have,cloned
R6760	T10516	T10514	pobj	sequence,upon
R6761	T10517	T10516	amod	genomic,sequence
R6762	T10518	T10516	acl	reported,sequence
R6763	T10519	T10516	punct	", ",sequence
R6764	T10520	T10516	cc	and,sequence
R6765	T10521	T10522	det	the,sequence
R6766	T10522	T10516	conj	sequence,sequence
R6767	T10523	T10522	prep	of,sequence
R6768	T10524	T10525	det	the,clone
R6769	T10525	T10523	pobj	clone,of
R677	T1085	T1083	auxpass	been,cloned
R6770	T10526	T10525	compound	IMAGE,clone
R6771	T10527	T10525	compound	cDNA,clone
R6772	T10528	T10525	appos	4933429K08,clone
R6773	T10529	T10522	punct	: ,sequence
R6774	T10530	T10522	appos	T1XF,sequence
R6775	T10531	T10532	punct	(,ccatgttcagtcattggcaggtc
R6776	T10532	T10530	parataxis	ccatgttcagtcattggcaggtc,T1XF
R6777	T10533	T10532	nummod	5,ccatgttcagtcattggcaggtc
R6778	T10534	T10533	punct	',5
R6779	T10535	T10532	punct	-,ccatgttcagtcattggcaggtc
R678	T1086	T1083	prep	in,cloned
R6780	T10536	T10532	punct	-,ccatgttcagtcattggcaggtc
R6781	T10537	T10532	nummod	3,ccatgttcagtcattggcaggtc
R6782	T10538	T10532	punct	',ccatgttcagtcattggcaggtc
R6783	T10539	T10532	punct	),ccatgttcagtcattggcaggtc
R6784	T10540	T10530	punct	", ",T1XF
R6785	T10541	T10530	conj	T1XF2,T1XF
R6786	T10542	T10543	punct	(,ctgcagaaccaacagttcaag
R6787	T10543	T10541	parataxis	ctgcagaaccaacagttcaag,T1XF2
R6788	T10544	T10543	nummod	5,ctgcagaaccaacagttcaag
R6789	T10545	T10544	punct	',5
R679	T1087	T1086	pobj	humans,in
R6790	T10546	T10543	punct	-,ctgcagaaccaacagttcaag
R6791	T10547	T10543	punct	-,ctgcagaaccaacagttcaag
R6792	T10548	T10543	nummod	3,ctgcagaaccaacagttcaag
R6793	T10549	T10543	punct	',ctgcagaaccaacagttcaag
R6794	T10550	T10543	punct	),ctgcagaaccaacagttcaag
R6795	T10551	T10541	punct	", ",T1XF2
R6796	T10552	T10541	conj	T1XR1,T1XF2
R6797	T10553	T10554	punct	(,agatctgtgacatcacagctc
R6798	T10554	T10552	parataxis	agatctgtgacatcacagctc,T1XR1
R6799	T10555	T10554	nummod	5,agatctgtgacatcacagctc
R680	T1088	T1089	punct	[,1
R6800	T10556	T10555	punct	',5
R6801	T10557	T10554	punct	-,agatctgtgacatcacagctc
R6802	T10558	T10554	punct	-,agatctgtgacatcacagctc
R6803	T10559	T10554	nummod	3,agatctgtgacatcacagctc
R6804	T10560	T10554	punct	',agatctgtgacatcacagctc
R6805	T10561	T10554	punct	),agatctgtgacatcacagctc
R6806	T10562	T10552	punct	", ",T1XR1
R6807	T10563	T10552	conj	T1XR2,T1XR1
R6808	T10564	T10565	punct	(,ctcgagtcagttagtcttatccagctt
R6809	T10565	T10563	parataxis	ctcgagtcagttagtcttatccagctt,T1XR2
R681	T1089	T1083	parataxis	1,cloned
R6810	T10566	T10565	nummod	5,ctcgagtcagttagtcttatccagctt
R6811	T10567	T10566	punct	',5
R6812	T10568	T10565	punct	-,ctcgagtcagttagtcttatccagctt
R6813	T10569	T10565	punct	-,ctcgagtcagttagtcttatccagctt
R6814	T10570	T10565	nummod	3,ctcgagtcagttagtcttatccagctt
R6815	T10571	T10565	punct	',ctcgagtcagttagtcttatccagctt
R6816	T10572	T10565	punct	),ctcgagtcagttagtcttatccagctt
R6817	T10573	T10563	punct	", ",T1XR2
R6818	T10574	T10563	conj	BB617F,T1XR2
R6819	T10575	T10576	punct	(,accaccaacttgagtacctg
R682	T1090	T1091	punct	-,3
R6820	T10576	T10574	parataxis	accaccaacttgagtacctg,BB617F
R6821	T10577	T10576	nummod	5,accaccaacttgagtacctg
R6822	T10578	T10577	punct	',5
R6823	T10579	T10576	punct	-,accaccaacttgagtacctg
R6824	T10580	T10576	punct	-,accaccaacttgagtacctg
R6825	T10581	T10576	nummod	3,accaccaacttgagtacctg
R6826	T10582	T10576	punct	',accaccaacttgagtacctg
R6827	T10583	T10576	punct	),accaccaacttgagtacctg
R6828	T10584	T10574	cc	and,BB617F
R6829	T10585	T10574	conj	BB617R,BB617F
R683	T1091	T1089	prep	3,1
R6830	T10586	T10587	punct	(,gtatcttgaactgttggttctg
R6831	T10587	T10585	parataxis	gtatcttgaactgttggttctg,BB617R
R6832	T10588	T10587	nummod	5,gtatcttgaactgttggttctg
R6833	T10589	T10588	punct	',5
R6834	T10590	T10587	punct	-,gtatcttgaactgttggttctg
R6835	T10591	T10587	punct	-,gtatcttgaactgttggttctg
R6836	T10592	T10587	nummod	3,gtatcttgaactgttggttctg
R6837	T10593	T10587	punct	',gtatcttgaactgttggttctg
R6838	T10594	T10587	punct	),gtatcttgaactgttggttctg
R6839	T10595	T10503	punct	.,based
R684	T1092	T1089	punct	],1
R6840	T10597	T10598	prep	For,located
R6841	T10599	T10597	pobj	analysis,For
R6842	T10600	T10599	prep	of,analysis
R6843	T10601	T10602	compound	TACC1,variants
R6844	T10602	T10600	pobj	variants,of
R6845	T10603	T10602	compound	splice,variants
R6846	T10604	T10598	punct	", ",located
R6847	T10605	T10606	det	the,primers
R6848	T10606	T10598	nsubjpass	primers,located
R6849	T10607	T10606	amod	forward,primers
R685	T1093	T1075	punct	", ",one
R6850	T10608	T10606	acl	used,primers
R6851	T10609	T10598	auxpass	were,located
R6852	T10610	T10598	prep	in,located
R6853	T10611	T10610	pobj	exon,in
R6854	T10612	T10611	nummod	1b,exon
R6855	T10613	T10611	punct	: ,exon
R6856	T10614	T10615	dep	EF,gagagatgcgaaatcagcg
R6857	T10615	T10611	parataxis	gagagatgcgaaatcagcg,exon
R6858	T10616	T10615	punct	(,gagagatgcgaaatcagcg
R6859	T10617	T10615	nummod	5,gagagatgcgaaatcagcg
R686	T1094	T1075	prep	in,one
R6860	T10618	T10617	punct	',5
R6861	T10619	T10615	punct	-,gagagatgcgaaatcagcg
R6862	T10620	T10615	punct	-,gagagatgcgaaatcagcg
R6863	T10621	T10615	nummod	3,gagagatgcgaaatcagcg
R6864	T10622	T10615	punct	',gagagatgcgaaatcagcg
R6865	T10623	T10615	punct	),gagagatgcgaaatcagcg
R6866	T10624	T10611	punct	", ",exon
R6867	T10625	T10611	appos	Exon,exon
R6868	T10626	T10625	nummod	1d,Exon
R6869	T10627	T10625	punct	: ,Exon
R687	T1095	T1094	pobj	each,in
R6870	T10628	T10629	dep	X3F,agtcaaagaaggcatctgcag
R6871	T10629	T10625	parataxis	agtcaaagaaggcatctgcag,Exon
R6872	T10630	T10629	punct	(,agtcaaagaaggcatctgcag
R6873	T10631	T10629	nummod	5,agtcaaagaaggcatctgcag
R6874	T10632	T10631	punct	',5
R6875	T10633	T10629	punct	-,agtcaaagaaggcatctgcag
R6876	T10634	T10629	punct	-,agtcaaagaaggcatctgcag
R6877	T10635	T10629	nummod	3,agtcaaagaaggcatctgcag
R6878	T10636	T10629	punct	',agtcaaagaaggcatctgcag
R6879	T10637	T10629	punct	),agtcaaagaaggcatctgcag
R688	T1096	T1095	prep	of,each
R6880	T10638	T10611	punct	", ",exon
R6881	T10639	T10611	appos	Exon,exon
R6882	T10640	T10639	nummod	1a,Exon
R6883	T10641	T10639	punct	: ,Exon
R6884	T10642	T10643	dep	1DF,ccaagttctgcgccatggg
R6885	T10643	T10639	parataxis	ccaagttctgcgccatggg,Exon
R6886	T10644	T10643	punct	(,ccaagttctgcgccatggg
R6887	T10645	T10643	nummod	5,ccaagttctgcgccatggg
R6888	T10646	T10645	punct	',5
R6889	T10647	T10643	punct	-,ccaagttctgcgccatggg
R689	T1097	T1096	pobj	mouse,of
R6890	T10648	T10643	punct	-,ccaagttctgcgccatggg
R6891	T10649	T10643	nummod	3,ccaagttctgcgccatggg
R6892	T10650	T10643	punct	',ccaagttctgcgccatggg
R6893	T10651	T10643	punct	),ccaagttctgcgccatggg
R6894	T10652	T10598	punct	.,located
R6895	T10654	T10655	det	The,primers
R6896	T10655	T10657	nsubj	primers,were
R6897	T10656	T10655	amod	reverse,primers
R6898	T10658	T10655	acl	used,primers
R6899	T10659	T10657	punct	: ,were
R690	T1098	T1099	punct	[,7
R6900	T10660	T10657	attr	Exon,were
R6901	T10661	T10660	nummod	1,Exon
R6902	T10662	T10660	punct	: ,Exon
R6903	T10663	T10664	dep	X1R,ggatttggtctcggcttgcgaatc
R6904	T10664	T10660	parataxis	ggatttggtctcggcttgcgaatc,Exon
R6905	T10665	T10664	punct	(,ggatttggtctcggcttgcgaatc
R6906	T10666	T10664	nummod	5,ggatttggtctcggcttgcgaatc
R6907	T10667	T10666	punct	',5
R6908	T10668	T10664	punct	-,ggatttggtctcggcttgcgaatc
R6909	T10669	T10664	punct	-,ggatttggtctcggcttgcgaatc
R691	T1099	T1097	parataxis	7,mouse
R6910	T10670	T10664	nummod	3,ggatttggtctcggcttgcgaatc
R6911	T10671	T10664	punct	',ggatttggtctcggcttgcgaatc
R6912	T10672	T10664	punct	),ggatttggtctcggcttgcgaatc
R6913	T10673	T10660	punct	", ",Exon
R6914	T10674	T10660	appos	Exon,Exon
R6915	T10675	T10674	nummod	2,Exon
R6916	T10676	T10674	punct	: ,Exon
R6917	T10677	T10678	dep	BX647R,cttgtgattcttggcttttgg
R6918	T10678	T10674	parataxis	cttgtgattcttggcttttgg,Exon
R6919	T10679	T10678	punct	(,cttgtgattcttggcttttgg
R692	T1100	T1099	punct	],7
R6920	T10680	T10678	nummod	5,cttgtgattcttggcttttgg
R6921	T10681	T10680	punct	',5
R6922	T10682	T10678	punct	-,cttgtgattcttggcttttgg
R6923	T10683	T10678	punct	-,cttgtgattcttggcttttgg
R6924	T10684	T10678	nummod	3,cttgtgattcttggcttttgg
R6925	T10685	T10678	punct	',cttgtgattcttggcttttgg
R6926	T10686	T10678	punct	),cttgtgattcttggcttttgg
R6927	T10687	T10660	punct	", ",Exon
R6928	T10688	T10660	appos	Exon,Exon
R6929	T10689	T10688	nummod	3,Exon
R693	T1101	T1097	punct	", ",mouse
R6930	T10690	T10688	punct	: ,Exon
R6931	T10691	T10692	dep	6SPR,gtcatcgcctcgtcctggagggc
R6932	T10692	T10688	parataxis	gtcatcgcctcgtcctggagggc,Exon
R6933	T10693	T10692	punct	(,gtcatcgcctcgtcctggagggc
R6934	T10694	T10692	nummod	5,gtcatcgcctcgtcctggagggc
R6935	T10695	T10694	punct	',5
R6936	T10696	T10692	punct	-,gtcatcgcctcgtcctggagggc
R6937	T10697	T10692	punct	-,gtcatcgcctcgtcctggagggc
R6938	T10698	T10692	nummod	3,gtcatcgcctcgtcctggagggc
R6939	T10699	T10692	punct	',gtcatcgcctcgtcctggagggc
R694	T1102	T1103	compound	Xenopus,laevis
R6940	T10700	T10692	punct	),gtcatcgcctcgtcctggagggc
R6941	T10701	T10660	punct	", ",Exon
R6942	T10702	T10703	compound	Exon,4a
R6943	T10703	T10660	appos	4a,Exon
R6944	T10704	T10703	punct	: ,4a
R6945	T10705	T10706	dep	1DR,aatttcacttgttcagtagtc
R6946	T10706	T10703	parataxis	aatttcacttgttcagtagtc,4a
R6947	T10707	T10706	punct	(,aatttcacttgttcagtagtc
R6948	T10708	T10706	nummod	5,aatttcacttgttcagtagtc
R6949	T10709	T10708	punct	',5
R695	T1103	T1097	conj	laevis,mouse
R6950	T10710	T10706	punct	-,aatttcacttgttcagtagtc
R6951	T10711	T10706	punct	-,aatttcacttgttcagtagtc
R6952	T10712	T10706	nummod	3,aatttcacttgttcagtagtc
R6953	T10713	T10706	punct	',aatttcacttgttcagtagtc
R6954	T10714	T10706	punct	),aatttcacttgttcagtagtc
R6955	T10715	T10660	punct	", ",Exon
R6956	T10716	T10660	appos	Exon,Exon
R6957	T10717	T10716	nummod	5,Exon
R6958	T10718	T10716	punct	: ,Exon
R6959	T10719	T10720	dep	128R,cctgcttctgaggatgaaaacgc
R696	T1104	T1105	punct	[,8
R6960	T10720	T10716	parataxis	cctgcttctgaggatgaaaacgc,Exon
R6961	T10721	T10720	punct	(,cctgcttctgaggatgaaaacgc
R6962	T10722	T10720	nummod	5,cctgcttctgaggatgaaaacgc
R6963	T10723	T10722	punct	',5
R6964	T10724	T10720	punct	-,cctgcttctgaggatgaaaacgc
R6965	T10725	T10720	punct	-,cctgcttctgaggatgaaaacgc
R6966	T10726	T10720	nummod	3,cctgcttctgaggatgaaaacgc
R6967	T10727	T10720	punct	',cctgcttctgaggatgaaaacgc
R6968	T10728	T10720	punct	),cctgcttctgaggatgaaaacgc
R6969	T10729	T10657	punct	.,were
R697	T1105	T1103	parataxis	8,laevis
R6970	T10731	T10732	compound	Rabbit,brain
R6971	T10732	T10733	compound	brain,mRNA
R6972	T10733	T10736	nsubjpass	mRNA,obtained
R6973	T10734	T10733	compound	poly,mRNA
R6974	T10735	T10733	compound	A+,mRNA
R6975	T10737	T10733	punct	", ",mRNA
R6976	T10738	T10739	compound	mouse,testis
R6977	T10739	T10733	conj	testis,mRNA
R6978	T10740	T10739	cc	and,testis
R6979	T10741	T10742	amod	human,brain
R698	T1106	T1105	punct	],8
R6980	T10742	T10743	nmod	brain,RNA
R6981	T10743	T10739	conj	RNA,testis
R6982	T10744	T10743	amod	total,RNA
R6983	T10745	T10736	auxpass	were,obtained
R6984	T10746	T10736	prep	from,obtained
R6985	T10747	T10748	compound	BD,Clontech
R6986	T10748	T10746	pobj	Clontech,from
R6987	T10749	T10748	compound	Bioscience,Clontech
R6988	T10750	T10748	punct	(,Clontech
R6989	T10751	T10752	compound	Palo,Alto
R699	T1107	T1103	punct	", ",laevis
R6990	T10752	T10748	appos	Alto,Clontech
R6991	T10753	T10752	punct	", ",Alto
R6992	T10754	T10752	npadvmod	CA,Alto
R6993	T10755	T10752	punct	", ",Alto
R6994	T10756	T10752	npadvmod	U.S.A.,Alto
R6995	T10757	T10748	punct	),Clontech
R6996	T10758	T10736	punct	.,obtained
R6997	T10760	T10761	amod	Reverse,transcription
R6998	T10761	T10762	nsubjpass	transcription,performed
R6999	T10763	T10761	cc	and,transcription
R700	T1108	T1109	compound	D.,melanogaster
R7000	T10764	T10761	conj	PCR,transcription
R7001	T10765	T10762	auxpass	was,performed
R7002	T10766	T10767	mark	as,described
R7003	T10767	T10762	advcl	described,performed
R7004	T10768	T10767	advmod	previously,described
R7005	T10769	T10762	punct	", ",performed
R7006	T10770	T10762	advcl	using,performed
R7007	T10771	T10772	preconj	either,μg
R7008	T10772	T10770	dobj	μg,using
R7009	T10773	T10772	nummod	1,μg
R701	T1109	T1103	conj	melanogaster,laevis
R7010	T10774	T10772	prep	of,μg
R7011	T10775	T10776	amod	total,RNA
R7012	T10776	T10774	pobj	RNA,of
R7013	T10777	T10772	cc	or,μg
R7014	T10778	T10779	nummod	50,ng
R7015	T10779	T10772	conj	ng,μg
R7016	T10780	T10779	prep	of,ng
R7017	T10781	T10782	compound	poly,A+
R7018	T10782	T10783	compound	A+,mRNA
R7019	T10783	T10780	pobj	mRNA,of
R702	T1110	T1111	punct	[,4
R7020	T10784	T10770	prep	as,using
R7021	T10785	T10784	pobj	template,as
R7022	T10786	T10785	prep	for,template
R7023	T10787	T10788	amod	first,strand
R7024	T10788	T10789	compound	strand,cDNA
R7025	T10789	T10790	compound	cDNA,synthesis
R7026	T10790	T10786	pobj	synthesis,for
R7027	T10791	T10762	punct	.,performed
R7028	T10793	T10794	compound	PCR,products
R7029	T10794	T10795	nsubjpass	products,cloned
R703	T1111	T1109	parataxis	4,melanogaster
R7030	T10796	T10795	auxpass	were,cloned
R7031	T10797	T10795	prep	into,cloned
R7032	T10798	T10797	pobj	pCR2.1,into
R7033	T10799	T10800	punct	(,Invitrogen
R7034	T10800	T10798	parataxis	Invitrogen,pCR2.1
R7035	T10801	T10800	punct	", ",Invitrogen
R7036	T10802	T10800	npadvmod	Carlsbad,Invitrogen
R7037	T10803	T10800	npadvmod	CA,Invitrogen
R7038	T10804	T10800	punct	", ",Invitrogen
R7039	T10805	T10800	npadvmod	U.S.A.,Invitrogen
R704	T1112	T1111	punct	],4
R7040	T10806	T10800	punct	),Invitrogen
R7041	T10807	T10795	cc	and,cloned
R7042	T10808	T10795	conj	transformed,cloned
R7043	T10809	T10808	prep	into,transformed
R7044	T10810	T10811	poss	InvαF,competent
R7045	T10811	T10813	amod	competent,cells
R7046	T10812	T10810	case	',InvαF
R7047	T10813	T10809	pobj	cells,into
R7048	T10814	T10795	punct	.,cloned
R7049	T10816	T10817	compound	Plasmid,inserts
R705	T1113	T1109	punct	", ",melanogaster
R7050	T10817	T10818	nsubjpass	inserts,sequenced
R7051	T10819	T10818	auxpass	were,sequenced
R7052	T10820	T10818	agent	by,sequenced
R7053	T10821	T10822	det	the,Facility
R7054	T10822	T10820	pobj	Facility,by
R7055	T10823	T10824	compound	Roswell,Park
R7056	T10824	T10825	compound	Park,Institute
R7057	T10825	T10822	compound	Institute,Facility
R7058	T10826	T10825	compound	Cancer,Institute
R7059	T10827	T10828	compound	Biopolymer,Core
R706	T1114	T1109	cc	and,melanogaster
R7060	T10828	T10822	compound	Core,Facility
R7061	T10829	T10818	punct	.,sequenced
R7062	T10983	T10982	prep	of,Deposition
R7063	T10984	T10985	compound	nucleotide,sequences
R7064	T10985	T10983	pobj	sequences,of
R7065	T10987	T10988	nsubjpass	Sequences,deposited
R7066	T10989	T10987	prep	from,Sequences
R7067	T10990	T10991	det	this,article
R7068	T10991	T10989	pobj	article,from
R7069	T10992	T10988	aux	have,deposited
R707	T1115	T1116	compound	C.,elegans
R7070	T10993	T10988	auxpass	been,deposited
R7071	T10994	T10988	prep	in,deposited
R7072	T10995	T10996	det	the,database
R7073	T10996	T10994	pobj	database,in
R7074	T10997	T10996	compound	GenBank,database
R7075	T10998	T10988	prep	with,deposited
R7076	T10999	T11000	det	the,numbers
R7077	T11000	T10998	pobj	numbers,with
R7078	T11001	T11000	amod	following,numbers
R7079	T11002	T11000	compound	accession,numbers
R708	T1116	T1109	conj	elegans,melanogaster
R7080	T11003	T11000	punct	: ,numbers
R7081	T11004	T11005	nmod	Homo,sapiens
R7082	T11005	T11006	nmod	sapiens,S
R7083	T11006	T11000	appos	S,numbers
R7084	T11007	T11006	nmod	TACC1,S
R7085	T11008	T11009	amod	short,isoform
R7086	T11009	T11006	compound	isoform,S
R7087	T11010	T11011	punct	(,AY177411
R7088	T11011	T11006	parataxis	AY177411,S
R7089	T11012	T11011	punct	),AY177411
R709	T1117	T1118	punct	[,6
R7090	T11013	T11006	punct	", ",S
R7091	T11014	T11015	nmod	Mus,musculus
R7092	T11015	T11016	nmod	musculus,S
R7093	T11016	T11006	appos	S,S
R7094	T11017	T11016	nmod	TACC1,S
R7095	T11018	T11019	amod	short,isoform
R7096	T11019	T11016	compound	isoform,S
R7097	T11020	T11021	punct	(,AY177412
R7098	T11021	T11016	parataxis	AY177412,S
R7099	T11022	T11021	punct	),AY177412
R710	T1118	T1116	parataxis	6,elegans
R7100	T11023	T11006	punct	", ",S
R7101	T11024	T11025	nmod	Mus,musculus
R7102	T11025	T11026	nmod	musculus,A
R7103	T11026	T11006	appos	A,S
R7104	T11027	T11026	nmod	TACC1,A
R7105	T11028	T11029	amod	long,isoform
R7106	T11029	T11026	compound	isoform,A
R7107	T11030	T11031	punct	(,AY177413
R7108	T11031	T11026	parataxis	AY177413,A
R7109	T11032	T11031	punct	),AY177413
R711	T1119	T1118	nummod	5,6
R7110	T11033	T11006	punct	", ",S
R7111	T11034	T11035	compound	Mus,musculus
R7112	T11035	T11036	compound	musculus,TACC2s
R7113	T11036	T11006	appos	TACC2s,S
R7114	T11037	T11038	punct	(,AY177410
R7115	T11038	T11036	parataxis	AY177410,TACC2s
R7116	T11039	T11038	punct	),AY177410
R7117	T11040	T11006	punct	", ",S
R7118	T11041	T11042	compound	Oryctolagus,cuniculus
R7119	T11042	T11043	compound	cuniculus,TACC3
R712	T1120	T1118	punct	",",6
R7120	T11043	T11006	appos	TACC3,S
R7121	T11044	T11045	punct	(,AY161270
R7122	T11045	T11043	parataxis	AY161270,TACC3
R7123	T11046	T11045	punct	),AY161270
R7124	T11047	T11006	punct	", ",S
R7125	T11048	T11049	compound	Danio,rerio
R7126	T11049	T11050	compound	rerio,TACC3
R7127	T11050	T11006	appos	TACC3,S
R7128	T11051	T11052	punct	(,AY170618
R7129	T11052	T11050	parataxis	AY170618,TACC3
R713	T1121	T1118	punct	],6
R7130	T11053	T11052	punct	),AY170618
R7131	T11054	T10988	punct	.,deposited
R7132	T11056	T11057	nsubj	Annotations,are
R7133	T11058	T11056	acl	submitted,Annotations
R7134	T11059	T11058	prep	to,submitted
R7135	T11060	T11061	det	the,database
R7136	T11061	T11059	pobj	database,to
R7137	T11062	T11063	amod	Third,party
R7138	T11063	T11061	compound	party,database
R7139	T11064	T11061	compound	annotation,database
R714	T1122	T1075	punct	.,one
R7140	T11065	T11061	prep	at,database
R7141	T11066	T11065	pobj	NCBI,at
R7142	T11067	T11068	mark	as,follows
R7143	T11068	T11057	advcl	follows,are
R7144	T11069	T11057	punct	: ,are
R7145	T11070	T11071	nmod	Rattus,norvegus
R7146	T11071	T11072	nmod	norvegus,A
R7147	T11072	T11057	dep	A,are
R7148	T11073	T11072	nmod	TACC1,A
R7149	T11074	T11075	amod	long,isoform
R715	T1124	T1125	mark	Although,proposed
R7150	T11075	T11072	compound	isoform,A
R7151	T11076	T11077	punct	(,BK001653
R7152	T11077	T11072	parataxis	BK001653,A
R7153	T11078	T11077	punct	),BK001653
R7154	T11079	T11072	punct	", ",A
R7155	T11080	T11081	compound	Takifugu,rubripes
R7156	T11081	T11082	compound	rubripes,TACC1A
R7157	T11082	T11072	appos	TACC1A,A
R7158	T11083	T11084	punct	(,BK000667
R7159	T11084	T11082	parataxis	BK000667,TACC1A
R716	T1125	T1148	advcl	proposed,is
R7160	T11085	T11084	compound	BK000666,BK000667
R7161	T11086	T11084	punct	/,BK000667
R7162	T11087	T11084	punct	),BK000667
R7163	T11088	T11072	punct	", ",A
R7164	T11089	T11090	compound	Takifugu,rubripes
R7165	T11090	T11091	compound	rubripes,TACC1B
R7166	T11091	T11072	appos	TACC1B,A
R7167	T11092	T11093	punct	(,BK000664
R7168	T11093	T11091	parataxis	BK000664,TACC1B
R7169	T11094	T11093	punct	),BK000664
R717	T1126	T1127	nummod	two,members
R7170	T11095	T11072	punct	", ",A
R7171	T11096	T11097	compound	Mus,musculus
R7172	T11097	T11098	compound	musculus,TACC2l
R7173	T11098	T11072	appos	TACC2l,A
R7174	T11099	T11100	punct	(,BK001495
R7175	T11100	T11098	parataxis	BK001495,TACC2l
R7176	T11101	T11100	punct	),BK001495
R7177	T11102	T11072	punct	", ",A
R7178	T11103	T11104	compound	Rattus,norvegus
R7179	T11104	T11105	compound	norvegus,TACC2l
R718	T1127	T1125	nsubjpass	members,proposed
R7180	T11105	T11072	appos	TACC2l,A
R7181	T11106	T11107	punct	(,BK001658
R7182	T11107	T11105	parataxis	BK001658,TACC2l
R7183	T11108	T11107	punct	),BK001658
R7184	T11109	T11072	punct	", ",A
R7185	T11110	T11111	compound	Rattus,norvegus
R7186	T11111	T11112	compound	norvegus,TACC2s
R7187	T11112	T11072	appos	TACC2s,A
R7188	T11113	T11114	punct	(,BK001657
R7189	T11114	T11112	parataxis	BK001657,TACC2s
R719	T1128	T1127	amod	additional,members
R7190	T11115	T11114	punct	),BK001657
R7191	T11116	T11072	punct	", ",A
R7192	T11117	T11118	compound	Takifugu,rubripes
R7193	T11118	T11119	compound	rubripes,TACC2l
R7194	T11119	T11072	appos	TACC2l,A
R7195	T11120	T11121	punct	(,BK000690
R7196	T11121	T11119	parataxis	BK000690,TACC2l
R7197	T11122	T11121	punct	),BK000690
R7198	T11123	T11072	punct	", ",A
R7199	T11124	T11125	compound	Rattus,norvegus
R720	T1129	T1127	amod	new,members
R7200	T11125	T11126	compound	norvegus,TACC3
R7201	T11126	T11072	appos	TACC3,A
R7202	T11127	T11128	punct	(,BK001491
R7203	T11128	T11126	parataxis	BK001491,TACC3
R7204	T11129	T11128	punct	),BK001491
R7205	T11130	T11072	punct	", ",A
R7206	T11131	T11132	compound	Gallus,gallus
R7207	T11132	T11133	compound	gallus,TACC3
R7208	T11133	T11072	appos	TACC3,A
R7209	T11134	T11135	punct	(,BK001482
R721	T1130	T1127	compound	candidate,members
R7210	T11135	T11133	parataxis	BK001482,TACC3
R7211	T11136	T11135	punct	),BK001482
R7212	T11137	T11072	punct	", ",A
R7213	T11138	T11139	compound	Silurana,tropicalis
R7214	T11139	T11140	compound	tropicalis,TACC3
R7215	T11140	T11072	appos	TACC3,A
R7216	T11141	T11142	punct	(,BK001481
R7217	T11142	T11140	parataxis	BK001481,TACC3
R7218	T11143	T11142	punct	),BK001481
R7219	T11144	T11072	punct	",",A
R722	T1131	T1127	compound	TACC,members
R7220	T11145	T11146	compound	Takifugu,rubripes
R7221	T11146	T11147	compound	rubripes,TACC3
R7222	T11147	T11072	appos	TACC3,A
R7223	T11148	T11149	punct	(,BK000649
R7224	T11149	T11147	parataxis	BK000649,TACC3
R7225	T11150	T11149	punct	),BK000649
R7226	T11151	T11072	punct	", ",A
R7227	T11152	T11153	compound	Takifugu,rubripes
R7228	T11153	T11154	compound	rubripes,RHAMM
R7229	T11154	T11072	appos	RHAMM,A
R723	T1132	T1127	compound	family,members
R7230	T11155	T11156	punct	(,BK000676
R7231	T11156	T11154	parataxis	BK000676,RHAMM
R7232	T11157	T11156	punct	),BK000676
R7233	T11158	T11072	punct	", ",A
R7234	T11159	T11160	compound	Ciona,intestinalis
R7235	T11160	T11161	compound	intestinalis,RHAMM
R7236	T11161	T11072	appos	RHAMM,A
R7237	T11162	T11163	punct	(,BK001479
R7238	T11163	T11161	parataxis	BK001479,RHAMM
R7239	T11164	T11163	punct	),BK001479
R724	T1133	T1127	punct	", ",members
R7240	T11165	T11072	punct	", ",A
R7241	T11166	T11167	compound	Takifugu,rubripes
R7242	T11167	T11168	compound	rubripes,Keratin
R7243	T11168	T11072	appos	Keratin,A
R7244	T11169	T11170	punct	(,BK000677
R7245	T11170	T11168	parataxis	BK000677,Keratin
R7246	T11171	T11170	punct	),BK000677
R7247	T11172	T11072	punct	", ",A
R7248	T11173	T11174	compound	Takifugu,rubripes
R7249	T11174	T11175	compound	rubripes,TPM1
R725	T1134	T1135	compound	Oryctolagus,TACC4
R7250	T11175	T11072	appos	TPM1,A
R7251	T11176	T11177	punct	(,BAC10576
R7252	T11177	T11175	parataxis	BAC10576,TPM1
R7253	T11178	T11177	punct	),BAC10576
R7254	T11179	T11072	punct	", ",A
R7255	T11180	T11181	compound	Ciona,intestinalis
R7256	T11181	T11182	compound	intestinalis,Kif3b
R7257	T11182	T11072	appos	Kif3b,A
R7258	T11183	T11184	punct	(,BK001492
R7259	T11184	T11182	parataxis	BK001492,Kif3b
R726	T1135	T1127	appos	TACC4,members
R7260	T11185	T11184	punct	),BK001492
R7261	T11186	T11072	punct	", ",A
R7262	T11187	T11188	compound	Ciona,intestinalis
R7263	T11188	T11189	compound	intestinalis,klp2
R7264	T11189	T11072	appos	klp2,A
R7265	T11190	T11191	punct	(,BK001493
R7266	T11191	T11189	parataxis	BK001493,klp2
R7267	T11192	T11191	punct	),BK001493
R7268	T11193	T11057	punct	.,are
R7269	T11434	T11435	amod	Phylogenetic,analysis
R727	T1136	T1135	compound	cuniculus,TACC4
R7270	T11437	T11438	prep	In,retrieved
R7271	T11439	T11437	pobj	order,In
R7272	T11440	T11441	aux	to,examine
R7273	T11441	T11439	acl	examine,order
R7274	T11442	T11443	amod	evolutionary,relationships
R7275	T11443	T11441	dobj	relationships,examine
R7276	T11444	T11443	prep	of,relationships
R7277	T11445	T11444	pobj	proteins,of
R7278	T11446	T11445	acl	containing,proteins
R7279	T11447	T11448	amod	coiled,coil
R728	T1137	T1138	punct	[,9
R7280	T11448	T11449	compound	coil,domains
R7281	T11449	T11446	dobj	domains,containing
R7282	T11450	T11438	punct	", ",retrieved
R7283	T11451	T11452	compound	protein,sequences
R7284	T11452	T11438	nsubjpass	sequences,retrieved
R7285	T11453	T11452	acl	representing,sequences
R7286	T11454	T11455	det	the,members
R7287	T11455	T11453	dobj	members,representing
R7288	T11456	T11455	amod	major,members
R7289	T11457	T11455	prep	of,members
R729	T1138	T1135	parataxis	9,TACC4
R7290	T11458	T11459	det	this,family
R7291	T11459	T11457	pobj	family,of
R7292	T11460	T11459	amod	super,family
R7293	T11461	T11452	punct	", ",sequences
R7294	T11462	T11452	prep	including,sequences
R7295	T11463	T11462	pobj	TACC,including
R7296	T11464	T11463	punct	", ",TACC
R7297	T11465	T11463	conj	RHAMM,TACC
R7298	T11466	T11465	punct	", ",RHAMM
R7299	T11467	T11465	conj	KLP,RHAMM
R730	T1139	T1138	punct	],9
R7300	T11468	T11467	punct	", ",KLP
R7301	T11469	T11467	conj	keratin,KLP
R7302	T11470	T11469	cc	and,keratin
R7303	T11471	T11469	conj	tropomyosin,keratin
R7304	T11472	T11452	prep	from,sequences
R7305	T11473	T11474	amod	available,vertebrates
R7306	T11474	T11472	pobj	vertebrates,from
R7307	T11475	T11474	cc	and,vertebrates
R7308	T11476	T11477	poss	their,orthologues
R7309	T11477	T11474	conj	orthologues,vertebrates
R731	T1140	T1135	cc	and,TACC4
R7310	T11478	T11477	amod	recognizable,orthologues
R7311	T11479	T11477	prep	from,orthologues
R7312	T11480	T11481	det	the,urochordate
R7313	T11481	T11479	pobj	urochordate,from
R7314	T11482	T11483	compound	Ciona,intestinalis
R7315	T11483	T11481	appos	intestinalis,urochordate
R7316	T11484	T11481	punct	", ",urochordate
R7317	T11485	T11486	compound	Drosophila,melanogaster
R7318	T11486	T11481	conj	melanogaster,urochordate
R7319	T11487	T11486	punct	", ",melanogaster
R732	T1141	T1142	amod	human,RHAMM
R7320	T11488	T11489	compound	C.,elegans
R7321	T11489	T11486	conj	elegans,melanogaster
R7322	T11490	T11489	cc	and,elegans
R7323	T11491	T11492	compound	Saccharomyces,cerevisiae
R7324	T11492	T11489	conj	cerevisiae,elegans
R7325	T11493	T11438	auxpass	were,retrieved
R7326	T11494	T11438	preconj	either,retrieved
R7327	T11495	T11438	advmod	directly,retrieved
R7328	T11496	T11438	prep	from,retrieved
R7329	T11497	T11498	compound	NCBI,databases
R733	T1142	T1135	conj	RHAMM,TACC4
R7330	T11498	T11496	pobj	databases,from
R7331	T11499	T11498	compound	sequence,databases
R7332	T11500	T11498	punct	", ",databases
R7333	T11501	T11502	advmod	newly,predicted
R7334	T11502	T11498	acl	predicted,databases
R7335	T11503	T11438	cc	or,retrieved
R7336	T11504	T11438	conj	isolated,retrieved
R7337	T11505	T11506	punct	(,see
R7338	T11506	T11504	parataxis	see,isolated
R7339	T11507	T11506	advmod	above,see
R734	T1143	T1144	punct	[,10
R7340	T11508	T11506	punct	),see
R7341	T11509	T11438	punct	.,retrieved
R7342	T11511	T11512	compound	Species,abbreviations
R7343	T11512	T11513	nsubj	abbreviations,are
R7344	T11514	T11515	mark	as,follows
R7345	T11515	T11513	advcl	follows,are
R7346	T11516	T11513	punct	: ,are
R7347	T11517	T11513	dep	hs,are
R7348	T11518	T11517	punct	(,hs
R7349	T11519	T11520	compound	Homo,sapiens
R735	T1144	T1142	parataxis	10,RHAMM
R7350	T11520	T11517	appos	sapiens,hs
R7351	T11521	T11517	punct	),hs
R7352	T11522	T11517	punct	", ",hs
R7353	T11523	T11517	appos	mm,hs
R7354	T11524	T11523	punct	(,mm
R7355	T11525	T11526	compound	Mus,musculus
R7356	T11526	T11523	appos	musculus,mm
R7357	T11527	T11517	punct	),hs
R7358	T11528	T11517	punct	", ",hs
R7359	T11529	T11517	appos	rn,hs
R736	T1145	T1144	punct	],10
R7360	T11530	T11529	punct	(,rn
R7361	T11531	T11532	compound	Rattus,norvegus
R7362	T11532	T11529	appos	norvegus,rn
R7363	T11533	T11517	punct	),hs
R7364	T11534	T11517	punct	", ",hs
R7365	T11535	T11517	appos	oc,hs
R7366	T11536	T11535	punct	(,oc
R7367	T11537	T11538	compound	Oryctolagus,cuniculus
R7368	T11538	T11535	appos	cuniculus,oc
R7369	T11539	T11517	punct	),hs
R737	T1146	T1125	aux	have,proposed
R7370	T11540	T11517	punct	", ",hs
R7371	T11541	T11517	appos	gg,hs
R7372	T11542	T11541	punct	(,gg
R7373	T11543	T11544	compound	Gallus,gallus
R7374	T11544	T11541	appos	gallus,gg
R7375	T11545	T11517	punct	),hs
R7376	T11546	T11517	punct	", ",hs
R7377	T11547	T11517	appos	xl,hs
R7378	T11548	T11547	punct	(,xl
R7379	T11549	T11550	compound	Xenopus,laevis
R738	T1147	T1125	auxpass	been,proposed
R7380	T11550	T11547	appos	laevis,xl
R7381	T11551	T11517	punct	),hs
R7382	T11552	T11517	punct	", ",hs
R7383	T11553	T11517	appos	st,hs
R7384	T11554	T11553	punct	(,st
R7385	T11555	T11556	compound	Silurana,tropicalis
R7386	T11556	T11553	appos	tropicalis,st
R7387	T11557	T11517	punct	),hs
R7388	T11558	T11517	punct	", ",hs
R7389	T11559	T11517	appos	tr,hs
R739	T1149	T1148	punct	", ",is
R7390	T11560	T11559	punct	(,tr
R7391	T11561	T11562	compound	Takifugu,rubripes
R7392	T11562	T11559	appos	rubripes,tr
R7393	T11563	T11517	punct	),hs
R7394	T11564	T11517	punct	", ",hs
R7395	T11565	T11517	appos	dr,hs
R7396	T11566	T11565	punct	(,dr
R7397	T11567	T11568	compound	Danio,rerio
R7398	T11568	T11565	appos	rerio,dr
R7399	T11569	T11517	punct	),hs
R740	T1150	T1151	poss	their,identity
R7400	T11570	T11517	punct	", ",hs
R7401	T11571	T11517	appos	ci,hs
R7402	T11572	T11571	punct	(,ci
R7403	T11573	T11574	compound	Ciona,intestinalis
R7404	T11574	T11571	appos	intestinalis,ci
R7405	T11575	T11517	punct	),hs
R7406	T11576	T11517	punct	", ",hs
R7407	T11577	T11517	appos	dm,hs
R7408	T11578	T11577	punct	(,dm
R7409	T11579	T11580	compound	D.,melanogaster
R741	T1151	T1148	nsubj	identity,is
R7410	T11580	T11577	appos	melanogaster,dm
R7411	T11581	T11517	punct	),hs
R7412	T11582	T11517	punct	", ",hs
R7413	T11583	T11517	appos	ce,hs
R7414	T11584	T11583	punct	(,ce
R7415	T11585	T11586	compound	C.,elegans
R7416	T11586	T11583	appos	elegans,ce
R7417	T11587	T11517	punct	),hs
R7418	T11588	T11517	punct	", ",hs
R7419	T11589	T11517	appos	sc,hs
R742	T1152	T1151	amod	true,identity
R7420	T11590	T11589	punct	(,sc
R7421	T11591	T11592	compound	Saccharomyces,cerevisiae
R7422	T11592	T11589	appos	cerevisiae,sc
R7423	T11593	T11517	punct	),hs
R7424	T11594	T11513	punct	.,are
R7425	T11596	T11597	det	The,sequences
R7426	T11597	T11598	nsubjpass	sequences,used
R7427	T11599	T11597	acl	identified,sequences
R7428	T11600	T11599	advmod	above,identified
R7429	T11601	T11597	cc	and,sequences
R743	T1153	T1151	cc	and,identity
R7430	T11602	T11603	det	the,translations
R7431	T11603	T11597	conj	translations,sequences
R7432	T11604	T11603	amod	following,translations
R7433	T11605	T11603	nmod	protein,translations
R7434	T11606	T11605	cc	or,protein
R7435	T11607	T11605	conj	predicted,protein
R7436	T11608	T11598	auxpass	were,used
R7437	T11609	T11598	prep	for,used
R7438	T11610	T11611	amod	phylogenetic,analysis
R7439	T11611	T11609	pobj	analysis,for
R744	T1154	T1151	conj	placement,identity
R7440	T11612	T11598	punct	: ,used
R7441	T11613	T11598	dep	hsTACC1A,used
R7442	T11614	T11615	punct	(,NP_006274
R7443	T11615	T11613	parataxis	NP_006274,hsTACC1A
R7444	T11616	T11615	punct	),NP_006274
R7445	T11617	T11613	punct	", ",hsTACC1A
R7446	T11618	T11613	appos	hsTACC2l,hsTACC1A
R7447	T11619	T11620	punct	(,AAO62630
R7448	T11620	T11618	parataxis	AAO62630,hsTACC2l
R7449	T11621	T11620	punct	),AAO62630
R745	T1155	T1151	prep	in,identity
R7450	T11622	T11613	appos	hsTACC2s,hsTACC1A
R7451	T11623	T11624	punct	(,AAO62629
R7452	T11624	T11622	parataxis	AAO62629,hsTACC2s
R7453	T11625	T11624	punct	),AAO62629
R7454	T11626	T11613	punct	", ",hsTACC1A
R7455	T11627	T11613	appos	hsTACC3,hsTACC1A
R7456	T11628	T11629	punct	(,NP_006333
R7457	T11629	T11627	parataxis	NP_006333,hsTACC3
R7458	T11630	T11629	punct	),NP_006333
R7459	T11631	T11613	punct	", ",hsTACC1A
R746	T1156	T1157	det	the,evolution
R7460	T11632	T11613	appos	mmTACC3,hsTACC1A
R7461	T11633	T11634	punct	(,Q9JJ11
R7462	T11634	T11632	parataxis	Q9JJ11,mmTACC3
R7463	T11635	T11634	punct	),Q9JJ11
R7464	T11636	T11613	punct	", ",hsTACC1A
R7465	T11637	T11613	appos	xlMaskin,hsTACC1A
R7466	T11638	T11639	punct	(,Q9PTG8
R7467	T11639	T11637	parataxis	Q9PTG8,xlMaskin
R7468	T11640	T11639	punct	),Q9PTG8
R7469	T11641	T11613	punct	", ",hsTACC1A
R747	T1157	T1155	pobj	evolution,in
R7470	T11642	T11613	appos	dmTACC,hsTACC1A
R7471	T11643	T11644	punct	(,AAF52099
R7472	T11644	T11642	parataxis	AAF52099,dmTACC
R7473	T11645	T11644	punct	),AAF52099
R7474	T11646	T11613	punct	", ",hsTACC1A
R7475	T11647	T11613	appos	ceTAC1,hsTACC1A
R7476	T11648	T11649	punct	(,NP_497059
R7477	T11649	T11647	parataxis	NP_497059,ceTAC1
R7478	T11650	T11649	punct	),NP_497059
R7479	T11651	T11613	punct	", ",hsTACC1A
R748	T1158	T1157	prep	of,evolution
R7480	T11652	T11613	appos	scSPC72,hsTACC1A
R7481	T11653	T11654	punct	(,NP_009352
R7482	T11654	T11652	parataxis	NP_009352,scSPC72
R7483	T11655	T11654	punct	),NP_009352
R7484	T11656	T11613	punct	", ",hsTACC1A
R7485	T11657	T11613	appos	hsRHAMM,hsTACC1A
R7486	T11658	T11659	punct	(,NP_036616
R7487	T11659	T11657	parataxis	NP_036616,hsRHAMM
R7488	T11660	T11659	punct	),NP_036616
R7489	T11661	T11613	punct	", ",hsTACC1A
R749	T1159	T1160	det	the,family
R7490	T11662	T11613	appos	mmRHAMM,hsTACC1A
R7491	T11663	T11664	punct	(,NP_038580
R7492	T11664	T11662	parataxis	NP_038580,mmRHAMM
R7493	T11665	T11664	punct	),NP_038580
R7494	T11666	T11613	punct	", ",hsTACC1A
R7495	T11667	T11613	appos	rnRHAMM,hsTACC1A
R7496	T11668	T11669	punct	(,NP_037096
R7497	T11669	T11667	parataxis	NP_037096,rnRHAMM
R7498	T11670	T11669	punct	),NP_037096
R7499	T11671	T11613	punct	", ",hsTACC1A
R750	T1160	T1158	pobj	family,of
R7500	T11672	T11613	appos	drRHAMM,hsTACC1A
R7501	T11673	T11674	punct	(,AAQ97980
R7502	T11674	T11672	parataxis	AAQ97980,drRHAMM
R7503	T11675	T11674	punct	),AAQ97980
R7504	T11676	T11613	punct	", ",hsTACC1A
R7505	T11677	T11613	appos	hsKeratin,hsTACC1A
R7506	T11678	T11679	punct	(,CAB76828
R7507	T11679	T11677	parataxis	CAB76828,hsKeratin
R7508	T11680	T11679	punct	),CAB76828
R7509	T11681	T11613	punct	", ",hsTACC1A
R751	T1161	T1160	compound	TACC,family
R7510	T11682	T11613	appos	mmKeratin,hsTACC1A
R7511	T11683	T11684	punct	(,A61368
R7512	T11684	T11682	parataxis	A61368,mmKeratin
R7513	T11685	T11684	punct	),A61368
R7514	T11686	T11613	punct	", ",hsTACC1A
R7515	T11687	T11613	appos	rnKeratin,hsTACC1A
R7516	T11688	T11689	punct	(,XP_235679
R7517	T11689	T11687	parataxis	XP_235679,rnKeratin
R7518	T11690	T11689	punct	),XP_235679
R7519	T11691	T11613	punct	", ",hsTACC1A
R752	T1162	T1148	prep	under,is
R7520	T11692	T11613	appos	hsTPM1,hsTACC1A
R7521	T11693	T11694	punct	(,NP_000357
R7522	T11694	T11692	parataxis	NP_000357,hsTPM1
R7523	T11695	T11694	punct	),NP_000357
R7524	T11696	T11613	punct	", ",hsTACC1A
R7525	T11697	T11613	appos	mmTPM1,hsTACC1A
R7526	T11698	T11699	punct	(,NP_077745
R7527	T11699	T11697	parataxis	NP_077745,mmTPM1
R7528	T11700	T11699	punct	),NP_077745
R7529	T11701	T11613	punct	", ",hsTACC1A
R753	T1163	T1162	pobj	debate,under
R7530	T11702	T11613	appos	rnTPM1,hsTACC1A
R7531	T11703	T11704	punct	(,NP_62004
R7532	T11704	T11702	parataxis	NP_62004,rnTPM1
R7533	T11705	T11613	punct	", ",hsTACC1A
R7534	T11706	T11613	appos	drTPM1,hsTACC1A
R7535	T11707	T11708	punct	(,NP_571180
R7536	T11708	T11706	parataxis	NP_571180,drTPM1
R7537	T11709	T11708	punct	),NP_571180
R7538	T11710	T11613	appos	dmTPM1,hsTACC1A
R7539	T11711	T11712	punct	(,P06754
R754	T1164	T1148	punct	.,is
R7540	T11712	T11710	parataxis	P06754,dmTPM1
R7541	T11713	T11712	punct	),P06754
R7542	T11714	T11613	punct	", ",hsTACC1A
R7543	T11715	T11613	appos	ceTPM,hsTACC1A
R7544	T11716	T11717	punct	(,NP_493540
R7545	T11717	T11715	parataxis	NP_493540,ceTPM
R7546	T11718	T11717	punct	),NP_493540
R7547	T11719	T11613	appos	scTPM1,hsTACC1A
R7548	T11720	T11721	punct	(,P17536
R7549	T11721	T11719	parataxis	P17536,scTPM1
R755	T1166	T1167	advmod	Thus,resolve
R7550	T11722	T11721	punct	),P17536
R7551	T11723	T11613	punct	", ",hsTACC1A
R7552	T11724	T11613	appos	hsKLP2,hsTACC1A
R7553	T11725	T11726	punct	(,BAB03309
R7554	T11726	T11724	parataxis	BAB03309,hsKLP2
R7555	T11727	T11726	punct	),BAB03309
R7556	T11728	T11613	punct	", ",hsTACC1A
R7557	T11729	T11613	appos	rnKIF15,hsTACC1A
R7558	T11730	T11731	punct	(,AAP44513
R7559	T11731	T11729	parataxis	AAP44513,rnKIF15
R756	T1168	T1167	punct	", ",resolve
R7560	T11732	T11731	punct	),AAP44513
R7561	T11733	T11613	punct	", ",hsTACC1A
R7562	T11734	T11613	appos	xlKLP2,hsTACC1A
R7563	T11735	T11736	punct	(,CAA08879
R7564	T11736	T11734	parataxis	CAA08879,xlKLP2
R7565	T11737	T11736	punct	),CAA08879
R7566	T11738	T11613	punct	", ",hsTACC1A
R7567	T11739	T11613	appos	dmKLP2,hsTACC1A
R7568	T11740	T11741	punct	(,NP_476818
R7569	T11741	T11739	parataxis	NP_476818,dmKLP2
R757	T1169	T1170	det	the,identification
R7570	T11742	T11741	punct	),NP_476818
R7571	T11743	T11613	punct	", ",hsTACC1A
R7572	T11744	T11613	appos	ceKLP18,hsTACC1A
R7573	T11745	T11746	punct	(,AA034669
R7574	T11746	T11744	parataxis	AA034669,ceKLP18
R7575	T11747	T11746	punct	),AA034669
R7576	T11748	T11613	punct	", ",hsTACC1A
R7577	T11749	T11613	appos	hsKIF3A,hsTACC1A
R7578	T11750	T11751	punct	(,Q9Y496
R7579	T11751	T11749	parataxis	Q9Y496,hsKIF3A
R758	T1170	T1167	nsubj	identification,resolve
R7580	T11752	T11751	punct	),Q9Y496
R7581	T11753	T11613	punct	", ",hsTACC1A
R7582	T11754	T11613	appos	mmKIF3A,hsTACC1A
R7583	T11755	T11756	punct	(,NP_032469
R7584	T11756	T11754	parataxis	NP_032469,mmKIF3A
R7585	T11757	T11756	punct	),NP_032469
R7586	T11758	T11613	punct	", ",hsTACC1A
R7587	T11759	T11613	appos	rnKIF3A,hsTACC1A
R7588	T11760	T11761	punct	(,XP_340797
R7589	T11761	T11759	parataxis	XP_340797,rnKIF3A
R759	T1171	T1170	cc	and,identification
R7590	T11762	T11761	punct	),XP_340797
R7591	T11763	T11613	punct	", ",hsTACC1A
R7592	T11764	T11613	appos	xlKIF3A,hsTACC1A
R7593	T11765	T11766	punct	(,CAA08879
R7594	T11766	T11764	parataxis	CAA08879,xlKIF3A
R7595	T11767	T11766	punct	),CAA08879
R7596	T11768	T11613	punct	", ",hsTACC1A
R7597	T11769	T11613	appos	ceKLP11,hsTACC1A
R7598	T11770	T11771	punct	(,NP_741473
R7599	T11771	T11769	parataxis	NP_741473,ceKLP11
R760	T1172	T1173	amod	functional,characterization
R7600	T11772	T11771	punct	),NP_741473
R7601	T11773	T11613	punct	", ",hsTACC1A
R7602	T11774	T11613	appos	ciKIF3,hsTACC1A
R7603	T11775	T11776	punct	(,ci0100148992
R7604	T11776	T11774	parataxis	ci0100148992,ciKIF3
R7605	T11777	T11776	punct	),ci0100148992
R7606	T11778	T11613	punct	", ",hsTACC1A
R7607	T11779	T11613	appos	hsKIF3B,hsTACC1A
R7608	T11780	T11781	punct	(,NP_004789
R7609	T11781	T11779	parataxis	NP_004789,hsKIF3B
R761	T1173	T1170	conj	characterization,identification
R7610	T11782	T11781	punct	),NP_004789
R7611	T11783	T11613	punct	", ",hsTACC1A
R7612	T11784	T11613	appos	mmKIF3B,hsTACC1A
R7613	T11785	T11786	punct	(,NP_004789
R7614	T11786	T11784	parataxis	NP_004789,mmKIF3B
R7615	T11787	T11786	punct	),NP_004789
R7616	T11788	T11613	punct	", ",hsTACC1A
R7617	T11789	T11613	appos	rnKIF3B,hsTACC1A
R7618	T11790	T11791	punct	(,XP_215883
R7619	T11791	T11789	parataxis	XP_215883,rnKIF3B
R762	T1174	T1170	prep	of,identification
R7620	T11792	T11791	punct	),XP_215883
R7621	T11793	T11613	punct	", ",hsTACC1A
R7622	T11794	T11613	appos	dmKIF3B,hsTACC1A
R7623	T11795	T11796	punct	(,NP_524029
R7624	T11796	T11794	parataxis	NP_524029,dmKIF3B
R7625	T11797	T11796	punct	),NP_524029
R7626	T11798	T11613	punct	", ",hsTACC1A
R7627	T11799	T11613	appos	hsKIF3C,hsTACC1A
R7628	T11800	T11801	punct	(,NP_002245
R7629	T11801	T11799	parataxis	NP_002245,hsKIF3C
R763	T1175	T1176	amod	new,members
R7630	T11802	T11801	punct	),NP_002245
R7631	T11803	T11613	punct	", ",hsTACC1A
R7632	T11804	T11613	appos	mmKIF3C,hsTACC1A
R7633	T11805	T11806	punct	(,NP_032471
R7634	T11806	T11804	parataxis	NP_032471,mmKIF3C
R7635	T11807	T11806	punct	),NP_032471
R7636	T11808	T11613	punct	", ",hsTACC1A
R7637	T11809	T11613	appos	rnKIF3C,hsTACC1A
R7638	T11810	T11811	punct	(,NP_445938
R7639	T11811	T11809	parataxis	NP_445938,rnKIF3C
R764	T1176	T1174	pobj	members,of
R7640	T11812	T11811	punct	),NP_445938
R7641	T11813	T11613	punct	", ",hsTACC1A
R7642	T11814	T11613	appos	dmKIF3C,hsTACC1A
R7643	T11815	T11816	punct	(,NP_651939
R7644	T11816	T11814	parataxis	NP_651939,dmKIF3C
R7645	T11817	T11816	punct	),NP_651939
R7646	T11818	T11598	punct	.,used
R7647	T11820	T11821	det	These,sequences
R7648	T11821	T11823	nsubjpass	sequences,aligned
R7649	T11822	T11821	compound	protein,sequences
R765	T1177	T1176	prep	of,members
R7650	T11824	T11823	auxpass	were,aligned
R7651	T11825	T11823	advmod	initially,aligned
R7652	T11826	T11823	prep	with,aligned
R7653	T11827	T11828	compound	CLUSTAL,X
R7654	T11828	T11826	pobj	X,with
R7655	T11829	T11830	punct	[,38
R7656	T11830	T11823	parataxis	38,aligned
R7657	T11831	T11830	punct	],38
R7658	T11832	T11823	punct	.,aligned
R7659	T11834	T11835	amod	Minor,adjustments
R766	T1178	T1179	det	the,family
R7660	T11835	T11836	nsubjpass	adjustments,made
R7661	T11836	T11847	ccomp	made,saved
R7662	T11837	T11835	prep	to,adjustments
R7663	T11838	T11839	amod	certain,regions
R7664	T11839	T11837	pobj	regions,to
R7665	T11840	T11839	prep	of,regions
R7666	T11841	T11842	det	the,alignment
R7667	T11842	T11840	pobj	alignment,of
R7668	T11843	T11835	prep	for,adjustments
R7669	T11844	T11845	compound	optimization,purposes
R767	T1179	T1177	pobj	family,of
R7670	T11845	T11843	pobj	purposes,for
R7671	T11846	T11836	auxpass	were,made
R7672	T11848	T11836	prep	based,made
R7673	T11849	T11848	prep	on,based
R7674	T11850	T11851	amod	pairwise,alignments
R7675	T11851	T11849	pobj	alignments,on
R7676	T11852	T11847	punct	", ",saved
R7677	T11853	T11854	det	the,output
R7678	T11854	T11847	nsubj	output,saved
R7679	T11855	T11847	prep	in,saved
R768	T1180	T1179	compound	TACC,family
R7680	T11856	T11857	compound	PHYLIP,format
R7681	T11857	T11855	pobj	format,in
R7682	T11858	T11847	punct	", ",saved
R7683	T11859	T11860	prep	after,calculated
R7684	T11860	T11847	advcl	calculated,saved
R7685	T11861	T11859	pobj	which,after
R7686	T11862	T11860	punct	", ",calculated
R7687	T11863	T11864	det	the,distances
R7688	T11864	T11860	nsubjpass	distances,calculated
R7689	T11865	T11864	prep	between,distances
R769	T1181	T1170	prep	in,identification
R7690	T11866	T11865	pobj	proteins,between
R7691	T11867	T11860	auxpass	were,calculated
R7692	T11868	T11860	advcl	using,calculated
R7693	T11869	T11870	compound	Poisson,correction
R7694	T11870	T11868	dobj	correction,using
R7695	T11871	T11860	cc	and,calculated
R7696	T11872	T11873	det	the,trees
R7697	T11873	T11875	nsubjpass	trees,inferred
R7698	T11874	T11873	amod	Unrooted,trees
R7699	T11875	T11860	conj	inferred,calculated
R770	T1182	T1183	amod	other,organisms
R7700	T11876	T11875	auxpass	were,inferred
R7701	T11877	T11875	prep	with,inferred
R7702	T11878	T11879	det	the,method
R7703	T11879	T11877	pobj	method,with
R7704	T11880	T11879	compound	NJ,method
R7705	T11881	T11875	cc	and,inferred
R7706	T11882	T11883	advmod	then,displayed
R7707	T11883	T11875	conj	displayed,inferred
R7708	T11884	T11883	advcl	using,displayed
R7709	T11885	T11884	dobj	TreeView,using
R771	T1183	T1181	pobj	organisms,in
R7710	T11886	T11887	punct	[,39
R7711	T11887	T11883	parataxis	39,displayed
R7712	T11888	T11887	punct	],39
R7713	T11889	T11847	punct	.,saved
R7714	T11891	T11892	compound	Bootstrap,values
R7715	T11892	T11893	nsubjpass	values,shown
R7716	T11894	T11892	prep	above,values
R7717	T11895	T11894	pobj	700,above
R7718	T11896	T11892	prep	for,values
R7719	T11897	T11898	nummod	1000,trials
R772	T1184	T1170	punct	", ",identification
R7720	T11898	T11896	pobj	trials,for
R7721	T11899	T11893	auxpass	are,shown
R7722	T11900	T11893	prep	at,shown
R7723	T11901	T11902	det	the,node
R7724	T11902	T11900	pobj	node,at
R7725	T11903	T11893	punct	.,shown
R7726	T11905	T11906	aux	To,validate
R7727	T11906	T11907	advcl	validate,analyzed
R7728	T11908	T11909	det	the,tree
R7729	T11909	T11906	dobj	tree,validate
R773	T1185	T1186	advmod	alternatively,spliced
R7730	T11910	T11907	punct	", ",analyzed
R7731	T11911	T11912	det	the,set
R7732	T11912	T11907	nsubjpass	set,analyzed
R7733	T11913	T11912	amod	same,set
R7734	T11914	T11912	compound	sequence,set
R7735	T11915	T11907	auxpass	was,analyzed
R7736	T11916	T11907	prep	with,analyzed
R7737	T11917	T11916	pobj	tools,with
R7738	T11918	T11917	prep	in,tools
R7739	T11919	T11920	det	the,package
R774	T1186	T1187	amod	spliced,isoforms
R7740	T11920	T11918	pobj	package,in
R7741	T11921	T11920	compound	PHYLIP,package
R7742	T11922	T11923	punct	[,40
R7743	T11923	T11907	parataxis	40,analyzed
R7744	T11924	T11923	punct	],40
R7745	T11925	T11907	punct	", ",analyzed
R7746	T11926	T11907	advcl	using,analyzed
R7747	T11927	T11926	dobj	PRODIST,using
R7748	T11928	T11927	acl	followed,PRODIST
R7749	T11929	T11928	agent	by,followed
R775	T1187	T1170	conj	isoforms,identification
R7750	T11930	T11929	pobj	FITCH,by
R7751	T11931	T11930	cc	or,FITCH
R7752	T11932	T11930	conj	NEIGNBOR,FITCH
R7753	T11933	T11926	cc	and,using
R7754	T11934	T11935	dep	tree,displaying
R7755	T11935	T11926	conj	displaying,using
R7756	T11936	T11935	advcl	using,displaying
R7757	T11937	T11936	dobj	TreeView,using
R7758	T11938	T11907	punct	.,analyzed
R7759	T11940	T11941	det	This,method
R776	T1188	T1187	prep	of,isoforms
R7760	T11941	T11943	nsubj	method,produced
R7761	T11942	T11941	amod	additional,method
R7762	T11944	T11943	dobj	trees,produced
R7763	T11945	T11944	prep	with,trees
R7764	T11946	T11947	advmod	essentially,topology
R7765	T11947	T11945	pobj	topology,with
R7766	T11948	T11947	det	the,topology
R7767	T11949	T11947	amod	same,topology
R7768	T11950	T11951	punct	(,shown
R7769	T11951	T11943	parataxis	shown,produced
R777	T1189	T1190	det	each,TACC
R7770	T11952	T11951	nsubj	data,shown
R7771	T11953	T11951	neg	not,shown
R7772	T11954	T11951	punct	),shown
R7773	T11955	T11943	punct	.,produced
R7774	T12120	T12121	advmod	In,vitro
R7775	T12121	T12122	amod	vitro,interaction
R7776	T12123	T12122	prep	of,interaction
R7777	T12124	T12123	pobj	TACC2,of
R7778	T12125	T12124	cc	and,TACC2
R7779	T12126	T12124	conj	RXRβ3,TACC2
R778	T1190	T1188	pobj	TACC,of
R7780	T12128	T12129	det	The,cDNA
R7781	T12129	T12131	nsubjpass	cDNA,cloned
R7782	T12130	T12129	compound	TACC2,cDNA
R7783	T12132	T12131	auxpass	was,cloned
R7784	T12133	T12131	prep	into,cloned
R7785	T12134	T12135	compound	GST,pGEX5X2
R7786	T12135	T12133	pobj	pGEX5X2,into
R7787	T12136	T12135	compound	fusion,pGEX5X2
R7788	T12137	T12135	compound	vector,pGEX5X2
R7789	T12138	T12139	punct	(,Biosciences
R779	T1191	T1187	cc	and,isoforms
R7790	T12139	T12131	parataxis	Biosciences,cloned
R7791	T12140	T12139	compound	Amersham,Biosciences
R7792	T12141	T12139	punct	", ",Biosciences
R7793	T12142	T12139	npadvmod	Piscataway,Biosciences
R7794	T12143	T12139	punct	", ",Biosciences
R7795	T12144	T12139	npadvmod	NJ,Biosciences
R7796	T12145	T12139	punct	", ",Biosciences
R7797	T12146	T12139	npadvmod	USA,Biosciences
R7798	T12147	T12139	punct	),Biosciences
R7799	T12148	T12131	punct	.,cloned
R780	T1192	T1187	conj	comparison,isoforms
R7800	T12150	T12151	nmod	GST,proteins
R7801	T12151	T12156	nsubjpass	proteins,expressed
R7802	T12152	T12150	cc	and,GST
R7803	T12153	T12154	compound	GST,TACC2
R7804	T12154	T12150	conj	TACC2,GST
R7805	T12155	T12154	punct	-,TACC2
R7806	T12157	T12156	auxpass	were,expressed
R7807	T12158	T12156	prep	in,expressed
R7808	T12159	T12160	nmod	E.,coli
R7809	T12160	T12161	nmod	coli,S
R781	T1193	T1192	prep	of,comparison
R7810	T12161	T12158	pobj	S,in
R7811	T12162	T12161	nmod	BL21,S
R7812	T12163	T12164	punct	(,DE3
R7813	T12164	T12161	parataxis	DE3,S
R7814	T12165	T12164	punct	),DE3
R7815	T12166	T12161	nmod	plys,S
R7816	T12167	T12161	punct	"""",S
R7817	T12168	T12161	punct	"""",S
R7818	T12169	T12156	prep	with,expressed
R7819	T12170	T12171	nummod	1,mM
R782	T1194	T1195	det	the,relationship
R7820	T12171	T12172	compound	mM,IPTG
R7821	T12172	T12169	pobj	IPTG,with
R7822	T12173	T12172	prep	at,IPTG
R7823	T12174	T12175	nummod	37,°C
R7824	T12175	T12176	compound	°C,shaker
R7825	T12176	T12173	pobj	shaker,at
R7826	T12177	T12172	prep	for,IPTG
R7827	T12178	T12179	nummod	2,hrs
R7828	T12179	T12177	pobj	hrs,for
R7829	T12180	T12156	punct	.,expressed
R783	T1195	T1193	pobj	relationship,of
R7830	T12182	T12183	nsubjpass	Cells,harvested
R7831	T12184	T12185	punct	(,ml
R7832	T12185	T12182	parataxis	ml,Cells
R7833	T12186	T12185	nummod	50,ml
R7834	T12187	T12185	punct	),ml
R7835	T12188	T12183	auxpass	were,harvested
R7836	T12189	T12183	cc	and,harvested
R7837	T12190	T12183	conj	resuspended,harvested
R7838	T12191	T12190	prep	in,resuspended
R7839	T12192	T12193	nummod	5,ml
R784	T1196	T1195	amod	phylogenetic,relationship
R7840	T12193	T12191	pobj	ml,in
R7841	T12194	T12193	prep	of,ml
R7842	T12195	T12196	nummod	20,mM
R7843	T12196	T12197	compound	mM,HCl
R7844	T12197	T12194	pobj	HCl,of
R7845	T12198	T12197	compound	Tris,HCl
R7846	T12199	T12197	punct	-,HCl
R7847	T12200	T12197	npadvmod	pH.8.0,HCl
R7848	T12201	T12197	punct	", ",HCl
R7849	T12202	T12203	nummod	200,mM
R785	T1197	T1195	prep	of,relationship
R7850	T12203	T12204	compound	mM,NaCl
R7851	T12204	T12197	appos	NaCl,HCl
R7852	T12205	T12197	punct	", ",HCl
R7853	T12206	T12207	nummod	1,mM
R7854	T12207	T12208	compound	mM,EDTA
R7855	T12208	T12197	appos	EDTA,HCl
R7856	T12209	T12208	npadvmod	pH8.0,EDTA
R7857	T12210	T12197	punct	", ",HCl
R7858	T12211	T12212	compound	Protease,inhibitor
R7859	T12212	T12213	compound	inhibitor,set
R786	T1198	T1199	det	these,genes
R7860	T12213	T12197	appos	set,HCl
R7861	T12214	T12213	nummod	III,set
R7862	T12215	T12216	punct	(,Calbiochem
R7863	T12216	T12213	parataxis	Calbiochem,set
R7864	T12217	T12216	punct	),Calbiochem
R7865	T12218	T12183	punct	.,harvested
R7866	T12220	T12221	det	The,cells
R7867	T12221	T12222	nsubjpass	cells,lysed
R7868	T12223	T12222	auxpass	were,lysed
R7869	T12224	T12222	prep	by,lysed
R787	T1199	T1197	pobj	genes,of
R7870	T12225	T12224	pobj	sonication,by
R7871	T12226	T12222	cc	and,lysed
R7872	T12227	T12228	nsubj	lysate,cleared
R7873	T12228	T12222	conj	cleared,lysed
R7874	T12229	T12228	prep	by,cleared
R7875	T12230	T12229	pobj	centrifugation,by
R7876	T12231	T12230	prep	at,centrifugation
R7877	T12232	T12233	nummod	7500,rpm
R7878	T12233	T12231	pobj	rpm,at
R7879	T12234	T12230	prep	at,centrifugation
R788	T1200	T1195	amod	relative,relationship
R7880	T12235	T12236	nummod	4,°C
R7881	T12236	T12234	pobj	°C,at
R7882	T12237	T12230	prep	for,centrifugation
R7883	T12238	T12239	nummod	15,min
R7884	T12239	T12237	pobj	min,for
R7885	T12240	T12228	punct	.,cleared
R7886	T12242	T12243	det	The,lysate
R7887	T12243	T12245	nsubjpass	lysate,immobilized
R7888	T12244	T12243	amod	cleared,lysate
R7889	T12246	T12245	auxpass	was,immobilized
R789	T1201	T1200	prep	to,relative
R7890	T12247	T12245	prep	on,immobilized
R7891	T12248	T12249	compound	glutathione,sepharose
R7892	T12249	T12250	compound	sepharose,beads
R7893	T12250	T12247	pobj	beads,on
R7894	T12251	T12245	prep	in,immobilized
R7895	T12252	T12253	nummod	3,ml
R7896	T12253	T12251	pobj	ml,in
R7897	T12254	T12253	prep	of,ml
R7898	T12255	T12256	nummod	20,mM
R7899	T12256	T12257	compound	mM,HCl
R790	T1202	T1203	amod	other,members
R7900	T12257	T12254	pobj	HCl,of
R7901	T12258	T12257	compound	Tris,HCl
R7902	T12259	T12257	punct	-,HCl
R7903	T12260	T12257	npadvmod	pH.8.0,HCl
R7904	T12261	T12257	punct	", ",HCl
R7905	T12262	T12263	nummod	200,mM
R7906	T12263	T12264	compound	mM,NaCl
R7907	T12264	T12257	appos	NaCl,HCl
R7908	T12265	T12257	punct	", ",HCl
R7909	T12266	T12267	nummod	1,mM
R791	T1203	T1201	pobj	members,to
R7910	T12267	T12268	compound	mM,EDTA
R7911	T12268	T12257	appos	EDTA,HCl
R7912	T12269	T12268	npadvmod	pH8.0,EDTA
R7913	T12270	T12245	punct	),immobilized
R7914	T12271	T12245	punct	.,immobilized
R7915	T12273	T12274	compound	RXRβ3,cDNA
R7916	T12274	T12275	nsubjpass	cDNA,cloned
R7917	T12276	T12275	auxpass	was,cloned
R7918	T12277	T12275	prep	into,cloned
R7919	T12278	T12279	compound	pET,28C
R792	T1204	T1203	prep	of,members
R7920	T12279	T12277	pobj	28C,into
R7921	T12280	T12279	punct	(,28C
R7922	T12281	T12279	punct	+,28C
R7923	T12282	T12279	punct	),28C
R7924	T12283	T12284	punct	(,Invitrogen
R7925	T12284	T12279	parataxis	Invitrogen,28C
R7926	T12285	T12284	punct	", ",Invitrogen
R7927	T12286	T12284	npadvmod	Carlsbad,Invitrogen
R7928	T12287	T12284	punct	", ",Invitrogen
R7929	T12288	T12284	npadvmod	CA,Invitrogen
R793	T1205	T1206	det	the,superfamily
R7930	T12289	T12284	punct	", ",Invitrogen
R7931	T12290	T12284	npadvmod	USA,Invitrogen
R7932	T12291	T12284	punct	),Invitrogen
R7933	T12292	T12275	cc	and,cloned
R7934	T12293	T12294	nsubj	protein,synthesized
R7935	T12294	T12275	conj	synthesized,cloned
R7936	T12295	T12294	prep	by,synthesized
R7937	T12296	T12297	nmod	TNT,kit
R7938	T12297	T12295	pobj	kit,by
R7939	T12298	T12299	advmod	quick,coupled
R794	T1206	T1204	pobj	superfamily,of
R7940	T12299	T12297	amod	coupled,kit
R7941	T12300	T12301	compound	transcription,translation
R7942	T12301	T12297	compound	translation,kit
R7943	T12302	T12301	punct	/,translation
R7944	T12303	T12297	compound	system,kit
R7945	T12304	T12305	punct	(,Promega
R7946	T12305	T12297	parataxis	Promega,kit
R7947	T12306	T12305	punct	),Promega
R7948	T12307	T12294	cc	and,synthesized
R7949	T12308	T12294	conj	radiolabeled,synthesized
R795	T1207	T1208	amod	coiled,coil
R7950	T12309	T12308	prep	with,radiolabeled
R7951	T12310	T12311	compound	35S,methionine
R7952	T12311	T12309	pobj	methionine,with
R7953	T12312	T12308	prep	according,radiolabeled
R7954	T12313	T12312	prep	to,according
R7955	T12314	T12315	poss	manufacturer,instructions
R7956	T12315	T12313	pobj	instructions,to
R7957	T12316	T12314	case	's,manufacturer
R7958	T12317	T12294	punct	.,synthesized
R7959	T12319	T12320	nummod	100,μl
R796	T1208	T1206	compound	coil,superfamily
R7960	T12320	T12321	nsubjpass	μl,incubated
R7961	T12322	T12320	prep	of,μl
R7962	T12323	T12324	advmod	in,vitro
R7963	T12324	T12325	advmod	vitro,translated
R7964	T12325	T12326	amod	translated,protein
R7965	T12326	T12322	pobj	protein,of
R7966	T12327	T12326	compound	RXRβ3,protein
R7967	T12328	T12320	prep	in,μl
R7968	T12329	T12330	nummod	1,ml
R7969	T12330	T12328	pobj	ml,in
R797	T1209	T1167	aux	will,resolve
R7970	T12331	T12330	prep	of,ml
R7971	T12332	T12333	nummod	20,mM
R7972	T12333	T12334	compound	mM,HCl
R7973	T12334	T12331	pobj	HCl,of
R7974	T12335	T12334	compound	Tris,HCl
R7975	T12336	T12334	punct	-,HCl
R7976	T12337	T12334	npadvmod	pH.8.0,HCl
R7977	T12338	T12334	punct	", ",HCl
R7978	T12339	T12340	nummod	200,mM
R7979	T12340	T12341	compound	mM,NaCl
R798	T1210	T1211	det	this,issue
R7980	T12341	T12334	appos	NaCl,HCl
R7981	T12342	T12334	punct	", ",HCl
R7982	T12343	T12344	nummod	1,mM
R7983	T12344	T12345	compound	mM,EDTA
R7984	T12345	T12334	appos	EDTA,HCl
R7985	T12346	T12345	npadvmod	pH8.0,EDTA
R7986	T12347	T12321	auxpass	was,incubated
R7987	T12348	T12321	prep	at,incubated
R7988	T12349	T12350	nummod	4,°C
R7989	T12350	T12348	pobj	°C,at
R799	T1211	T1167	dobj	issue,resolve
R7990	T12351	T12321	prep	with,incubated
R7991	T12352	T12353	amod	immobilized,TACC2
R7992	T12353	T12351	pobj	TACC2,with
R7993	T12354	T12353	compound	GST,TACC2
R7994	T12355	T12353	punct	-,TACC2
R7995	T12356	T12353	cc	or,TACC2
R7996	T12357	T12353	conj	GST,TACC2
R7997	T12358	T12321	prep	for,incubated
R7998	T12359	T12360	nummod	90,min
R7999	T12360	T12358	pobj	min,for
R800	T1212	T1167	cc	and,resolve
R8000	T12361	T12321	punct	.,incubated
R8001	T12363	T12364	amod	Unbound,RXRβ3
R8002	T12364	T12365	nsubjpass	RXRβ3,removed
R8003	T12366	T12365	auxpass	was,removed
R8004	T12367	T12365	prep	by,removed
R8005	T12368	T12367	pcomp	washing,by
R8006	T12369	T12370	nummod	three,times
R8007	T12370	T12368	npadvmod	times,washing
R8008	T12371	T12368	prep	with,washing
R8009	T12372	T12373	nummod	20,mM
R801	T1213	T1167	conj	provide,resolve
R8010	T12373	T12374	compound	mM,HCl
R8011	T12374	T12371	pobj	HCl,with
R8012	T12375	T12374	compound	Tris,HCl
R8013	T12376	T12374	punct	-,HCl
R8014	T12377	T12374	npadvmod	pH.8.0,HCl
R8015	T12378	T12374	punct	", ",HCl
R8016	T12379	T12380	nummod	200,mM
R8017	T12380	T12381	compound	mM,NaCl
R8018	T12381	T12374	appos	NaCl,HCl
R8019	T12382	T12374	punct	", ",HCl
R802	T1214	T1213	dobj	clues,provide
R8020	T12383	T12384	nummod	1,mM
R8021	T12384	T12385	compound	mM,EDTA
R8022	T12385	T12374	appos	EDTA,HCl
R8023	T12386	T12385	npadvmod	pH8.0,EDTA
R8024	T12387	T12365	punct	.,removed
R8025	T12389	T12390	compound	Bound,proteins
R8026	T12390	T12391	nsubjpass	proteins,eluted
R8027	T12392	T12391	auxpass	were,eluted
R8028	T12393	T12391	prep	from,eluted
R8029	T12394	T12395	det	the,beads
R803	T1215	T1214	prep	to,clues
R8030	T12395	T12393	pobj	beads,from
R8031	T12396	T12391	prep	at,eluted
R8032	T12397	T12398	compound	room,temperature
R8033	T12398	T12396	pobj	temperature,at
R8034	T12399	T12391	prep	for,eluted
R8035	T12400	T12401	nummod	10,min
R8036	T12401	T12399	pobj	min,for
R8037	T12402	T12391	prep	in,eluted
R8038	T12403	T12404	compound	elution,buffer
R8039	T12404	T12402	pobj	buffer,in
R804	T1216	T1217	det	the,evolution
R8040	T12405	T12406	punct	(,HCl
R8041	T12406	T12404	parataxis	HCl,buffer
R8042	T12407	T12408	nummod	100,mM
R8043	T12408	T12406	compound	mM,HCl
R8044	T12409	T12406	compound	Tris,HCl
R8045	T12410	T12406	punct	", ",HCl
R8046	T12411	T12406	npadvmod	pH8.0,HCl
R8047	T12412	T12406	punct	", ",HCl
R8048	T12413	T12414	nummod	20,mM
R8049	T12414	T12415	nmod	mM,glutathione
R805	T1217	T1215	pobj	evolution,to
R8050	T12415	T12406	appos	glutathione,HCl
R8051	T12416	T12415	amod	reduced,glutathione
R8052	T12417	T12406	punct	),HCl
R8053	T12418	T12391	punct	.,eluted
R8054	T12420	T12421	det	The,proteins
R8055	T12421	T12422	nsubjpass	proteins,analyzed
R8056	T12423	T12422	auxpass	were,analyzed
R8057	T12424	T12422	prep	on,analyzed
R8058	T12425	T12426	nummod	12,%
R8059	T12426	T12427	compound	%,gels
R806	T1218	T1217	prep	of,evolution
R8060	T12427	T12424	pobj	gels,on
R8061	T12428	T12427	compound	SDS,gels
R8062	T12429	T12427	compound	polyacrylamide,gels
R8063	T12430	T12422	punct	.,analyzed
R8064	T12432	T12433	nmod	Coomassie,staining
R8065	T12433	T12435	nsubj	staining,verified
R8066	T12434	T12433	amod	blue,staining
R8067	T12436	T12437	amod	equal,loading
R8068	T12437	T12435	dobj	loading,verified
R8069	T12438	T12437	prep	of,loading
R807	T1219	T1220	compound	TACC,function
R8070	T12439	T12440	compound	GST,protein
R8071	T12440	T12438	pobj	protein,of
R8072	T12441	T12440	compound	fusion,protein
R8073	T12442	T12435	punct	.,verified
R8074	T12444	T12445	amod	Dried,gels
R8075	T12445	T12446	nsubjpass	gels,autoradiographed
R8076	T12447	T12446	auxpass	were,autoradiographed
R8077	T12448	T12446	punct	.,autoradiographed
R8078	T12469	T12470	amod	Phylogenetic,analysis
R8079	T12471	T12470	prep	of,analysis
R808	T1220	T1218	pobj	function,of
R8080	T12472	T12473	det	the,members
R8081	T12473	T12471	pobj	members,of
R8082	T12474	T12473	compound	TACC,members
R8083	T12475	T12473	compound	family,members
R8084	T12476	T12470	prep	compared,analysis
R8085	T12477	T12476	prep	to,compared
R8086	T12478	T12479	amod	other,proteins
R8087	T12479	T12477	pobj	proteins,to
R8088	T12480	T12481	amod	coiled,coil
R8089	T12481	T12479	compound	coil,proteins
R809	T1221	T1167	punct	.,resolve
R8090	T12482	T12470	punct	.,analysis
R8091	T12484	T12485	det	The,tree
R8092	T12485	T12487	nsubjpass	tree,constructed
R8093	T12486	T12485	amod	phylogenetic,tree
R8094	T12488	T12487	auxpass	was,constructed
R8095	T12489	T12490	mark	as,described
R8096	T12490	T12487	advcl	described,constructed
R8097	T12491	T12490	prep	in,described
R8098	T12492	T12493	det	the,section
R8099	T12493	T12491	pobj	section,in
R8100	T12494	T12493	compound	Methods,section
R8101	T12495	T12487	punct	.,constructed
R8102	T12497	T12498	det	The,family
R8103	T12498	T12500	nsubj	family,defines
R8104	T12499	T12498	compound	TACC,family
R8105	T12501	T12502	det	a,subfamily
R8106	T12502	T12500	dobj	subfamily,defines
R8107	T12503	T12502	amod	separate,subfamily
R8108	T12504	T12502	prep	of,subfamily
R8109	T12505	T12506	amod	coiled,coil
R811	T1593	T1594	advmod	In,silico
R8110	T12506	T12507	npadvmod	coil,containing
R8111	T12507	T12508	amod	containing,proteins
R8112	T12508	T12504	pobj	proteins,of
R8113	T12509	T12502	punct	", ",subfamily
R8114	T12510	T12502	amod	distinct,subfamily
R8115	T12511	T12510	prep	from,distinct
R8116	T12512	T12513	amod	other,families
R8117	T12513	T12511	pobj	families,from
R8118	T12514	T12515	amod	coiled,coil
R8119	T12515	T12513	compound	coil,families
R812	T1594	T1595	amod	silico,identification
R8120	T12516	T12517	amod	such,as
R8121	T12517	T12513	prep	as,families
R8122	T12518	T12519	det	the,keratins
R8123	T12519	T12517	pobj	keratins,as
R8124	T12520	T12519	punct	", ",keratins
R8125	T12521	T12519	conj	RHAMM,keratins
R8126	T12522	T12521	cc	and,RHAMM
R8127	T12523	T12521	conj	tropomyosins,RHAMM
R8128	T12524	T12500	punct	.,defines
R8129	T12527	T12528	mark	that,form
R813	T1596	T1595	prep	of,identification
R8130	T12528	T12526	ccomp	form,Note
R8131	T12529	T12530	det	the,proteins
R8132	T12530	T12528	nsubj	proteins,form
R8133	T12531	T12530	compound	RHAMM,proteins
R8134	T12532	T12533	det	a,branch
R8135	T12533	T12528	dobj	branch,form
R8136	T12534	T12533	amod	separate,branch
R8137	T12535	T12536	advmod	more,closely
R8138	T12536	T12537	advmod	closely,related
R8139	T12537	T12533	amod	related,branch
R814	T1597	T1598	compound	TACC,members
R8140	T12538	T12537	prep	to,related
R8141	T12539	T12540	det	the,tropomyosins
R8142	T12540	T12538	pobj	tropomyosins,to
R8143	T12541	T12540	cc	and,tropomyosins
R8144	T12542	T12543	npadvmod	kinesin,like
R8145	T12543	T12544	amod	like,proteins
R8146	T12544	T12540	conj	proteins,tropomyosins
R8147	T12545	T12544	punct	(,proteins
R8148	T12546	T12544	appos	KLP,proteins
R8149	T12547	T12537	punct	),related
R815	T1598	T1596	pobj	members,of
R8150	T12548	T12537	punct	", ",related
R8151	T12549	T12537	prep	than,related
R8152	T12550	T12551	det	the,proteins
R8153	T12551	T12549	pobj	proteins,than
R8154	T12552	T12551	compound	TACC,proteins
R8155	T12553	T12526	punct	.,Note
R8159	T12611	T12612	amod	Linear,organization
R816	T1599	T1598	compound	family,members
R8160	T12613	T12612	prep	of,organization
R8161	T12614	T12615	compound	gene,clusters
R8162	T12615	T12613	pobj	clusters,of
R8163	T12616	T12612	acl	centering,organization
R8164	T12617	T12616	prep	upon,centering
R8165	T12618	T12619	det	the,loci
R8166	T12619	T12617	pobj	loci,upon
R8167	T12620	T12619	amod	chromosomal,loci
R8168	T12621	T12619	prep	of,loci
R8169	T12622	T12623	det	the,genes
R817	T1600	T1598	prep	from,members
R8170	T12623	T12621	pobj	genes,of
R8171	T12624	T12623	compound	FGFR,genes
R8172	T12625	T12619	prep	in,loci
R8173	T12626	T12625	pobj	humans,in
R8174	T12627	T12612	punct	.,organization
R8175	T12629	T12630	amod	Paralogous,genes
R8176	T12630	T12631	nsubjpass	genes,shown
R8177	T12632	T12630	amod	present,genes
R8178	T12633	T12632	prep	in,present
R8179	T12634	T12635	advmod	at,two
R818	T1601	T1602	nmod	vertebrate,lineages
R8180	T12635	T12633	pobj	two,in
R8181	T12636	T12635	advmod	least,two
R8182	T12637	T12635	prep	of,two
R8183	T12638	T12639	det	the,loci
R8184	T12639	T12637	pobj	loci,of
R8185	T12640	T12639	nummod	four,loci
R8186	T12641	T12631	auxpass	are,shown
R8187	T12642	T12631	punct	", ",shown
R8188	T12643	T12631	prep	with,shown
R8189	T12644	T12645	det	the,exception
R819	T1602	T1600	pobj	lineages,from
R8190	T12645	T12643	pobj	exception,with
R8191	T12646	T12645	prep	of,exception
R8192	T12647	T12648	det	the,region
R8193	T12648	T12646	pobj	region,of
R8194	T12649	T12648	prep	between,region
R8195	T12650	T12649	pobj	GPX3,between
R8196	T12651	T12650	cc	and,GPX3
R8197	T12652	T12650	conj	NKX2E,GPX3
R8198	T12653	T12650	prep	on,GPX3
R8199	T12654	T12653	pobj	chromosome,on
R820	T1603	T1601	cc	and,vertebrate
R8200	T12655	T12654	nummod	5,chromosome
R8201	T12656	T12648	punct	", ",region
R8202	T12657	T12658	dep	which,appears
R8203	T12658	T12648	relcl	appears,region
R8204	T12659	T12660	aux	to,represent
R8205	T12660	T12658	xcomp	represent,appears
R8206	T12661	T12662	det	a,series
R8207	T12662	T12660	dobj	series,represent
R8208	T12663	T12662	prep	of,series
R8209	T12664	T12665	amod	intervening,genes
R821	T1604	T1601	conj	invertebrate,vertebrate
R8210	T12665	T12663	pobj	genes,of
R8211	T12666	T12662	acl	inserted,series
R8212	T12667	T12666	prep	after,inserted
R8213	T12668	T12667	pobj	duplication,after
R8214	T12669	T12668	prep	of,duplication
R8215	T12670	T12671	det	the,clusters
R8216	T12671	T12669	pobj	clusters,of
R8217	T12672	T12673	nmod	4p16,5q32
R8218	T12673	T12671	nmod	5q32,clusters
R8219	T12674	T12673	punct	/,5q32
R822	T1606	T1607	compound	Sequence,similarity
R8220	T12675	T12673	punct	-,5q32
R8221	T12676	T12673	nummod	35,5q32
R8222	T12677	T12648	punct	", ",region
R8223	T12678	T12648	cc	and,region
R8224	T12679	T12648	conj	genes,region
R8225	T12680	T12679	acl	mentioned,genes
R8226	T12681	T12680	prep	in,mentioned
R8227	T12682	T12681	pobj	Fig.,in
R8228	T12683	T12682	nummod	3,Fig.
R8229	T12684	T12631	punct	.,shown
R823	T1607	T1608	compound	similarity,searches
R8230	T12686	T12687	amod	Corresponding,regions
R8231	T12687	T12691	nsubjpass	regions,indicated
R8232	T12688	T12687	amod	syntenic,regions
R8233	T12689	T12687	nmod	mouse,regions
R8234	T12690	T12687	amod	chromosomal,regions
R8235	T12692	T12693	punct	(,mm
R8236	T12693	T12687	parataxis	mm,regions
R8237	T12694	T12693	punct	*,mm
R8238	T12695	T12693	punct	),mm
R8239	T12696	T12691	auxpass	are,indicated
R824	T1608	T1609	nsubjpass	searches,performed
R8240	T12697	T12691	punct	.,indicated
R8241	T12699	T12700	compound	Takifugu,rubripes
R8242	T12700	T12701	compound	rubripes,scaffolds
R8243	T12701	T12702	nsubjpass	scaffolds,shown
R8244	T12703	T12702	auxpass	are,shown
R8245	T12704	T12705	punct	(,TR
R8246	T12705	T12702	parataxis	TR,shown
R8247	T12706	T12705	punct	*,TR
R8248	T12707	T12705	punct	),TR
R8249	T12708	T12709	dep	that,contain
R825	T1610	T1608	prep	of,searches
R8250	T12709	T12702	ccomp	contain,shown
R8251	T12710	T12711	amod	more,one
R8252	T12711	T12713	nummod	one,gene
R8253	T12712	T12711	quantmod	than,one
R8254	T12713	T12709	dobj	gene,contain
R8255	T12714	T12713	amod	homologous,gene
R8256	T12715	T12713	prep	from,gene
R8257	T12716	T12717	det	these,clusters
R8258	T12717	T12715	pobj	clusters,from
R8259	T12718	T12702	punct	.,shown
R826	T1611	T1612	det	the,databases
R8260	T12720	T12721	amod	Further,details
R8261	T12721	T12722	nsubjpass	details,found
R8262	T12723	T12721	prep	on,details
R8263	T12724	T12725	det	the,location
R8264	T12725	T12723	pobj	location,on
R8265	T12726	T12725	prep	of,location
R8266	T12727	T12728	amod	paralogous,genes
R8267	T12728	T12726	pobj	genes,of
R8268	T12729	T12722	aux	can,found
R8269	T12730	T12722	auxpass	be,found
R827	T1612	T1610	pobj	databases,of
R8270	T12731	T12722	prep	in,found
R8271	T12732	T12733	punct	[,see
R8272	T12733	T12731	pcomp	see,in
R8273	T12734	T12735	amod	Additional,file
R8274	T12735	T12733	dobj	file,see
R8275	T12736	T12735	nummod	1,file
R8276	T12737	T12733	punct	],see
R8277	T12738	T12722	punct	.,found
R828	T1613	T1614	advmod	publicly,available
R8282	T12815	T12814	prep	of,Formation
R8283	T12816	T12815	pobj	protoclusters,of
R8284	T12817	T12814	prep	in,Formation
R8285	T12818	T12819	compound	Takifugu,rubripes
R8286	T12819	T12817	pobj	rubripes,in
R8287	T12820	T12819	cc	and,rubripes
R8288	T12821	T12822	compound	Ciona,intestinalis
R8289	T12822	T12819	conj	intestinalis,rubripes
R829	T1614	T1612	amod	available,databases
R8290	T12823	T12814	punct	: ,Formation
R8291	T12824	T12825	punct	(,A
R8292	T12825	T12827	meta	A,Structure
R8293	T12828	T12825	punct	),A
R8294	T12829	T12827	punct	: ,Structure
R8295	T12830	T12827	prep	of,Structure
R8296	T12831	T12832	det	the,scaffolds
R8297	T12832	T12830	pobj	scaffolds,of
R8298	T12833	T12832	amod	genomic,scaffolds
R8299	T12834	T12832	acl	containing,scaffolds
R830	T1615	T1612	compound	genome,databases
R8300	T12835	T12836	det	the,genes
R8301	T12836	T12834	dobj	genes,containing
R8302	T12837	T12838	nmod	Takifugu,rubripes
R8303	T12838	T12836	nmod	rubripes,genes
R8304	T12839	T12836	nmod	trTACC1A,genes
R8305	T12840	T12839	cc	and,trTACC1A
R8306	T12841	T12839	conj	trTACC1B,trTACC1A
R8307	T12842	T12827	punct	.,Structure
R8308	T12844	T12845	nsubj	Scaffold,contains
R8309	T12846	T12844	nummod	12,Scaffold
R831	T1616	T1612	prep	with,databases
R8310	T12847	T12844	punct	", ",Scaffold
R8311	T12848	T12849	det	the,site
R8312	T12849	T12844	appos	site,Scaffold
R8313	T12850	T12849	prep	for,site
R8314	T12851	T12852	det	the,gene
R8315	T12852	T12850	pobj	gene,for
R8316	T12853	T12852	compound	trTACC1A,gene
R8317	T12854	T12845	dobj	genes,contains
R8318	T12855	T12854	acl	found,genes
R8319	T12856	T12855	prep	with,found
R832	T1617	T1618	det	the,programs
R8320	T12857	T12858	preconj	either,homologues
R8321	T12858	T12856	pobj	homologues,with
R8322	T12859	T12858	cc	or,homologues
R8323	T12860	T12858	conj	orthologues,homologues
R8324	T12861	T12855	prep	on,found
R8325	T12862	T12863	det	the,arm
R8326	T12863	T12861	pobj	arm,on
R8327	T12864	T12863	amod	distal,arm
R8328	T12865	T12863	amod	long,arm
R8329	T12866	T12863	prep	of,arm
R833	T1618	T1616	pobj	programs,with
R8330	T12867	T12868	amod	human,4p16
R8331	T12868	T12866	pobj	4p16,of
R8332	T12869	T12868	nmod	chromosome,4p16
R8333	T12870	T12868	nummod	10,4p16
R8334	T12871	T12868	cc	and,4p16
R8335	T12872	T12845	punct	.,contains
R8336	T12874	T12875	det	This,scaffold
R8337	T12875	T12876	nsubj	scaffold,has
R8338	T12877	T12876	punct	", ",has
R8339	T12878	T12876	advmod	therefore,has
R834	T1619	T1618	nmod	BLAST,programs
R8340	T12879	T12876	punct	", ",has
R8341	T12880	T12876	dobj	some,has
R8342	T12881	T12880	prep	of,some
R8343	T12882	T12883	det	the,characteristics
R8344	T12883	T12881	pobj	characteristics,of
R8345	T12884	T12883	prep	of,characteristics
R8346	T12885	T12886	det	the,ancestor
R8347	T12886	T12884	pobj	ancestor,of
R8348	T12887	T12886	amod	predicted,ancestor
R8349	T12888	T12886	amod	immediate,ancestor
R835	T1620	T1619	cc	and,BLAST
R8350	T12889	T12886	prep	of,ancestor
R8351	T12890	T12891	det	the,segment
R8352	T12891	T12889	pobj	segment,of
R8353	T12892	T12893	nmod	TACC1,TACC2
R8354	T12893	T12891	nmod	TACC2,segment
R8355	T12894	T12893	punct	/,TACC2
R8356	T12895	T12891	amod	chromosomal,segment
R8357	T12896	T12876	punct	.,has
R8358	T12898	T12899	nsubjpass	trTACC1B,found
R8359	T12900	T12899	auxpass	is,found
R836	T1621	T1619	conj	TBLAST,BLAST
R8360	T12901	T12899	prep	on,found
R8361	T12902	T12901	pobj	scaffold,on
R8362	T12903	T12902	nummod	191,scaffold
R8363	T12904	T12902	punct	", ",scaffold
R8364	T12905	T12906	dep	which,contains
R8365	T12906	T12902	relcl	contains,scaffold
R8366	T12907	T12906	dobj	orthologues,contains
R8367	T12908	T12907	prep	of,orthologues
R8368	T12909	T12908	pobj	genes,of
R8369	T12910	T12909	acl	found,genes
R837	T1622	T1609	auxpass	were,performed
R8370	T12911	T12910	prep	in,found
R8371	T12912	T12913	det	the,arm
R8372	T12913	T12911	pobj	arm,in
R8373	T12914	T12913	amod	proximal,arm
R8374	T12915	T12913	amod	short,arm
R8375	T12916	T12913	prep	of,arm
R8376	T12917	T12918	amod	human,chromosome
R8377	T12918	T12916	pobj	chromosome,of
R8378	T12919	T12918	nummod	8,chromosome
R8379	T12920	T12899	punct	.,found
R838	T1623	T1624	aux	to,identify
R8380	T12922	T12923	punct	(,B
R8381	T12923	T12924	meta	B,clusters
R8382	T12925	T12923	punct	),B
R8383	T12926	T12924	punct	: ,clusters
R8384	T12927	T12928	compound	Ciona,intestinalis
R8385	T12928	T12924	compound	intestinalis,clusters
R8386	T12929	T12924	acl	containing,clusters
R8387	T12930	T12929	dobj	genes,containing
R8388	T12931	T12930	acl	found,genes
R8389	T12932	T12931	prep	in,found
R839	T1624	T1609	advcl	identify,performed
R8390	T12933	T12934	amod	paralogous,segments
R8391	T12934	T12932	pobj	segments,in
R8392	T12935	T12931	prep	on,found
R8393	T12936	T12937	amod	human,4p16
R8394	T12937	T12935	pobj	4p16,on
R8395	T12938	T12937	nummod	8,4p16
R8396	T12939	T12937	punct	", ",4p16
R8397	T12940	T12937	punct	", ",4p16
R8398	T12941	T12937	conj	10q,4p16
R8399	T12942	T12941	cc	and,10q
R840	T1625	T1626	nmod	TACC,orthologues
R8400	T12943	T12941	conj	5q,10q
R8401	T12944	T12924	punct	.,clusters
R8402	T12994	T12995	amod	Genomic,structure
R8403	T12996	T12995	prep	of,structure
R8404	T12997	T12998	det	the,genes
R8405	T12998	T12996	pobj	genes,of
R8406	T12999	T12998	compound	TACC,genes
R8407	T13000	T12995	punct	.,structure
R8408	T13002	T13003	amod	Conserved,regions
R8409	T13003	T13004	nsubjpass	regions,shown
R841	T1626	T1624	dobj	orthologues,identify
R8410	T13005	T13003	acl	known,regions
R8411	T13006	T13007	aux	to,bind
R8412	T13007	T13005	xcomp	bind,known
R8413	T13008	T13009	compound	protein,factors
R8414	T13009	T13007	dobj	factors,bind
R8415	T13010	T13007	prep	in,bind
R8416	T13011	T13012	det	all,proteins
R8417	T13012	T13010	pobj	proteins,in
R8418	T13013	T13012	amod	human,proteins
R8419	T13014	T13012	compound	TACC,proteins
R842	T1627	T1625	cc	and,TACC
R8420	T13015	T13004	auxpass	are,shown
R8421	T13016	T13004	punct	.,shown
R8422	T13018	T13019	det	The,repeat
R8423	T13019	T13021	nsubjpass	repeat,known
R8424	T13020	T13019	compound	SDP,repeat
R8425	T13022	T13019	prep	of,repeat
R8426	T13023	T13024	amod	human,TACC1
R8427	T13024	T13022	pobj	TACC1,of
R8428	T13025	T13024	punct	-,TACC1
R8429	T13026	T13024	nummod	3,TACC1
R843	T1628	T1625	conj	RHAMM,TACC
R8430	T13027	T13021	auxpass	is,known
R8431	T13028	T13029	aux	to,bind
R8432	T13029	T13021	xcomp	bind,known
R8433	T13030	T13029	dobj	GAS41,bind
R8434	T13031	T13032	punct	(,15
R8435	T13032	T13021	parataxis	15,known
R8436	T13033	T13032	punct	[,15
R8437	T13034	T13032	nummod	3,15
R8438	T13035	T13032	punct	",",15
R8439	T13036	T13032	punct	],15
R844	T1629	T1626	punct	", ",orthologues
R8440	T13037	T13032	cc	and,15
R8441	T13038	T13039	nsubj	data,shown
R8442	T13039	T13032	conj	shown,15
R8443	T13040	T13039	neg	not,shown
R8444	T13041	T13032	punct	),15
R8445	T13042	T13021	punct	.,known
R8446	T13044	T13045	det	The,domain
R8447	T13045	T13047	nsubj	domain,binds
R8448	T13046	T13045	compound	TACC,domain
R8449	T13048	T13049	compound	ch,TOG
R845	T1630	T1626	cc	and,orthologues
R8450	T13049	T13047	dobj	TOG,binds
R8451	T13050	T13049	punct	-,TOG
R8452	T13051	T13049	cc	and,TOG
R8453	T13052	T13049	conj	members,TOG
R8454	T13053	T13052	prep	of,members
R8455	T13054	T13055	det	the,kinases
R8456	T13055	T13053	pobj	kinases,of
R8457	T13056	T13055	compound	Aurora,kinases
R8458	T13057	T13047	prep	in,binds
R8459	T13058	T13059	det	all,species
R846	T1631	T1632	amod	other,members
R8460	T13059	T13057	pobj	species,in
R8461	T13060	T13059	acl	examined,species
R8462	T13061	T13060	prep	to,examined
R8463	T13062	T13061	pobj	date,to
R8464	T13063	T13047	punct	.,binds
R8465	T13065	T13066	det	This,motif
R8466	T13066	T13067	nsubjpass	motif,encoded
R8467	T13068	T13067	auxpass	is,encoded
R8468	T13069	T13067	advmod	characteristically,encoded
R8469	T13070	T13067	agent	by,encoded
R847	T1632	T1626	conj	members,orthologues
R8470	T13071	T13072	det	the,exons
R8471	T13072	T13070	pobj	exons,by
R8472	T13073	T13072	nummod	3,exons
R8473	T13074	T13073	punct	',3
R8474	T13075	T13072	prep	of,exons
R8475	T13076	T13077	det	the,genes
R8476	T13077	T13075	pobj	genes,of
R8477	T13078	T13077	compound	TACC,genes
R8478	T13079	T13067	punct	.,encoded
R8479	T13081	T13082	det	The,size
R848	T1633	T1632	prep	of,members
R8480	T13082	T13083	nsubjpass	size,shown
R8481	T13084	T13082	prep	of,size
R8482	T13085	T13086	det	the,isoform
R8483	T13086	T13084	pobj	isoform,of
R8484	T13087	T13086	amod	largest,isoform
R8485	T13088	T13086	prep	for,isoform
R8486	T13089	T13090	det	each,gene
R8487	T13090	T13088	pobj	gene,for
R8488	T13091	T13083	auxpass	is,shown
R8489	T13092	T13083	punct	.,shown
R849	T1634	T1635	det	the,superfamily
R8490	T13211	T13212	amod	Alternative,splicing
R8491	T13213	T13212	prep	of,splicing
R8492	T13214	T13215	det	the,gene
R8493	T13215	T13213	pobj	gene,of
R8494	T13216	T13215	amod	human,gene
R8495	T13217	T13215	compound	TACC1,gene
R8496	T13218	T13212	punct	.,splicing
R8497	T13220	T13221	punct	(,A
R8498	T13221	T13222	meta	A,identified
R8499	T13223	T13221	punct	),A
R850	T1635	T1633	pobj	superfamily,of
R8500	T13224	T13222	punct	: ,identified
R8501	T13225	T13226	nummod	Seven,variants
R8502	T13226	T13222	nsubjpass	variants,identified
R8503	T13227	T13226	compound	splice,variants
R8504	T13228	T13222	aux	have,identified
R8505	T13229	T13222	auxpass	been,identified
R8506	T13230	T13222	prep	for,identified
R8507	T13231	T13232	amod	human,TACC1
R8508	T13232	T13230	pobj	TACC1,for
R8509	T13233	T13234	punct	(,A
R851	T1636	T1637	amod	coiled,coil
R8510	T13234	T13222	parataxis	A,identified
R8511	T13235	T13236	punct	-,F
R8512	T13236	T13234	prep	F,A
R8513	T13237	T13234	cc	and,A
R8514	T13238	T13234	conj	S,A
R8515	T13239	T13234	punct	),A
R8516	T13240	T13222	punct	.,identified
R8517	T13242	T13243	nsubj	We,identified
R8518	T13244	T13243	aux	have,identified
R8519	T13245	T13243	advmod	also,identified
R852	T1637	T1635	compound	coil,superfamily
R8520	T13246	T13247	amod	additional,variants
R8521	T13247	T13243	dobj	variants,identified
R8522	T13248	T13247	compound	splice,variants
R8523	T13249	T13250	punct	(,G
R8524	T13250	T13247	parataxis	G,variants
R8525	T13251	T13252	punct	-,I
R8526	T13252	T13250	prep	I,G
R8527	T13253	T13250	punct	),G
R8528	T13254	T13243	prep	from,identified
R8529	T13255	T13256	compound	database,analysis
R853	T1638	T1624	prep	in,identify
R8530	T13256	T13254	pobj	analysis,from
R8531	T13257	T13256	cc	and,analysis
R8532	T13258	T13259	compound	rt,PCR
R8533	T13259	T13261	compound	PCR,analysis
R8534	T13260	T13259	punct	-,PCR
R8535	T13261	T13256	conj	analysis,analysis
R8536	T13262	T13261	prep	of,analysis
R8537	T13263	T13264	amod	human,brain
R8538	T13264	T13265	compound	brain,RNA
R8539	T13265	T13262	pobj	RNA,of
R854	T1639	T1640	det	a,set
R8540	T13266	T13243	punct	.,identified
R8541	T13268	T13269	punct	(,B
R8542	T13269	T13270	meta	B,splicing
R8543	T13271	T13269	punct	),B
R8544	T13272	T13270	punct	: ,splicing
R8545	T13273	T13270	amod	Alternative,splicing
R8546	T13274	T13270	prep	of,splicing
R8547	T13275	T13274	pobj	TACC1,of
R8548	T13276	T13270	prep	in,splicing
R8549	T13277	T13278	det	the,brain
R855	T1640	T1638	pobj	set,in
R8550	T13278	T13276	pobj	brain,in
R8551	T13279	T13278	amod	human,brain
R8552	T13280	T13270	punct	.,splicing
R8553	T13282	T13283	compound	rt,PCR
R8554	T13283	T13285	compound	PCR,analysis
R8555	T13284	T13283	punct	-,PCR
R8556	T13285	T13286	nsubj	analysis,confirms
R8557	T13287	T13286	dobj	splicing,confirms
R8558	T13288	T13287	prep	of,splicing
R8559	T13289	T13290	det	the,exon
R856	T1641	T1640	amod	diverse,set
R8560	T13290	T13288	pobj	exon,of
R8561	T13291	T13290	amod	untranslated,exon
R8562	T13292	T13290	nummod	1a,exon
R8563	T13293	T13287	prep	to,splicing
R8564	T13294	T13293	pobj	exon,to
R8565	T13295	T13294	nummod	1,exon
R8566	T13296	T13287	punct	", ",splicing
R8567	T13297	T13287	prep	with,splicing
R8568	T13298	T13297	pobj	retention,with
R8569	T13299	T13298	prep	of,retention
R857	T1642	T1640	prep	of,set
R8570	T13300	T13301	det	the,methionine
R8571	T13301	T13299	pobj	methionine,of
R8572	T13302	T13303	advmod	originally,defined
R8573	T13303	T13301	amod	defined,methionine
R8574	T13304	T13301	compound	start,methionine
R8575	T13305	T13306	punct	(,NP_006274
R8576	T13306	T13286	parataxis	NP_006274,confirms
R8577	T13307	T13306	nmod	GB,NP_006274
R8578	T13308	T13306	punct	:,NP_006274
R8579	T13309	T13306	punct	),NP_006274
R858	T1643	T1642	pobj	species,of
R8580	T13310	T13311	punct	(,1
R8581	T13311	T13286	parataxis	1,confirms
R8582	T13312	T13313	compound	Variant,A
R8583	T13313	T13311	dep	A,1
R8584	T13314	T13313	punct	*,A
R8585	T13315	T13311	punct	", ",1
R8586	T13316	T13311	nmod	lanes,1
R8587	T13317	T13311	cc	and,1
R8588	T13318	T13311	conj	3,1
R8589	T13319	T13311	punct	),1
R859	T1644	T1645	punct	(,Fig.
R8590	T13320	T13286	punct	.,confirms
R8591	T13322	T13323	nsubj	Exon,splices
R8592	T13324	T13322	nummod	1a,Exon
R8593	T13325	T13323	advmod	also,splices
R8594	T13326	T13323	prep	to,splices
R8595	T13327	T13326	pobj	exon,to
R8596	T13328	T13327	nummod	2,exon
R8597	T13329	T13323	punct	", ",splices
R8598	T13330	T13323	advcl	removing,splices
R8599	T13331	T13332	det	the,motif
R860	T1645	T1624	parataxis	Fig.,identify
R8600	T13332	T13330	dobj	motif,removing
R8601	T13333	T13334	compound	L,Sm7
R8602	T13334	T13332	compound	Sm7,motif
R8603	T13335	T13334	punct	-,Sm7
R8604	T13336	T13332	compound	binding,motif
R8605	T13337	T13338	punct	(,3
R8606	T13338	T13323	parataxis	3,splices
R8607	T13339	T13340	compound	variant,I
R8608	T13340	T13338	dep	I,3
R8609	T13341	T13338	punct	", ",3
R861	T1646	T1645	nummod	1,Fig.
R8610	T13342	T13338	nmod	lanes,3
R8611	T13343	T13338	punct	",",3
R8612	T13344	T13338	conj	12,3
R8613	T13345	T13344	cc	and,12
R8614	T13346	T13344	conj	13,12
R8615	T13347	T13338	punct	),3
R8616	T13348	T13323	punct	.,splices
R8617	T13350	T13351	nsubj	Variants,remove
R8618	T13352	T13353	dep	that,delete
R8619	T13353	T13350	relcl	delete,Variants
R862	T1647	T1645	punct	),Fig.
R8620	T13354	T13353	advmod	functionally,delete
R8621	T13355	T13356	nmod	exons,2
R8622	T13356	T13353	dobj	2,delete
R8623	T13357	T13356	cc	and,2
R8624	T13358	T13357	punct	/,and
R8625	T13359	T13357	cc	or,and
R8626	T13360	T13356	conj	3,2
R8627	T13361	T13350	punct	", ",Variants
R8628	T13362	T13363	amod	such,as
R8629	T13363	T13350	prep	as,Variants
R863	T1648	T1609	punct	.,performed
R8630	T13364	T13365	compound	variant,C
R8631	T13365	T13363	pobj	C,as
R8632	T13366	T13367	punct	(,lane
R8633	T13367	T13365	parataxis	lane,C
R8634	T13368	T13367	nummod	15,lane
R8635	T13369	T13367	punct	),lane
R8636	T13370	T13351	advmod	also,remove
R8637	T13371	T13372	det	the,signals
R8638	T13372	T13351	dobj	signals,remove
R8639	T13373	T13372	amod	predicted,signals
R864	T1650	T1651	nsubj	This,identified
R8640	T13374	T13375	amod	nuclear,localization
R8641	T13375	T13372	compound	localization,signals
R8642	T13376	T13372	punct	", ",signals
R8643	T13377	T13372	cc	and,signals
R8644	T13378	T13379	det	the,domains
R8645	T13379	T13372	conj	domains,signals
R8646	T13380	T13379	compound	binding,domains
R8647	T13381	T13379	prep	for,domains
R8648	T13382	T13381	pobj	GAS41,for
R8649	T13383	T13382	cc	and,GAS41
R865	T1652	T1653	det	the,sequence
R8650	T13384	T13382	conj	PCTAIRE2BP,GAS41
R8651	T13385	T13351	punct	.,remove
R8652	T13387	T13388	det	These,variants
R8653	T13388	T13389	nsubj	variants,retain
R8654	T13390	T13389	aux	would,retain
R8655	T13391	T13392	det	the,domain
R8656	T13392	T13389	dobj	domain,retain
R8657	T13393	T13392	compound	TACC,domain
R8658	T13394	T13392	punct	", ",domain
R8659	T13395	T13392	cc	and,domain
R866	T1653	T1651	dobj	sequence,identified
R8660	T13396	T13397	advmod	therefore,potential
R8661	T13397	T13392	conj	potential,domain
R8662	T13398	T13397	det	the,potential
R8663	T13399	T13400	aux	to,bind
R8664	T13400	T13397	acl	bind,potential
R8665	T13401	T13400	prep	to,bind
R8666	T13402	T13403	compound	ch,TOG
R8667	T13403	T13401	pobj	TOG,to
R8668	T13404	T13403	punct	-,TOG
R8669	T13405	T13403	cc	and,TOG
R867	T1654	T1653	amod	complete,sequence
R8670	T13406	T13407	compound	Aurora,A
R8671	T13407	T13408	compound	A,kinase
R8672	T13408	T13403	conj	kinase,TOG
R8673	T13409	T13400	prep	in,bind
R8674	T13410	T13411	det	the,centrosome
R8675	T13411	T13409	pobj	centrosome,in
R8676	T13412	T13389	punct	.,retain
R8677	T13414	T13415	dep	Lane,X1R
R8678	T13415	T13420	dep	X1R,ladder
R8679	T13416	T13414	nummod	1,Lane
R868	T1655	T1653	prep	of,sequence
R8680	T13417	T13415	punct	: ,X1R
R8681	T13418	T13415	compound	EF,X1R
R8682	T13419	T13415	punct	/,X1R
R8683	T13421	T13420	punct	", ",ladder
R8684	T13422	T13423	dep	Lane,BX647R
R8685	T13423	T13420	dep	BX647R,ladder
R8686	T13424	T13422	nummod	2,Lane
R8687	T13425	T13423	punct	: ,BX647R
R8688	T13426	T13423	compound	EF,BX647R
R8689	T13427	T13423	punct	/,BX647R
R869	T1656	T1657	det	the,genes
R8690	T13428	T13420	punct	", ",ladder
R8691	T13429	T13430	dep	Lane,6SPR
R8692	T13430	T13420	dep	6SPR,ladder
R8693	T13431	T13429	nummod	3,Lane
R8694	T13432	T13430	punct	: ,6SPR
R8695	T13433	T13430	compound	EF,6SPR
R8696	T13434	T13430	punct	/,6SPR
R8697	T13435	T13420	punct	", ",ladder
R8698	T13436	T13437	dep	Lane,1DR
R8699	T13437	T13420	dep	1DR,ladder
R870	T1657	T1655	pobj	genes,of
R8700	T13438	T13436	nummod	4,Lane
R8701	T13439	T13437	punct	: ,1DR
R8702	T13440	T13437	compound	EF,1DR
R8703	T13441	T13437	punct	/,1DR
R8704	T13442	T13420	punct	", ",ladder
R8705	T13443	T13444	dep	Lane,128R
R8706	T13444	T13420	dep	128R,ladder
R8707	T13445	T13443	nummod	5,Lane
R8708	T13446	T13444	punct	", ",128R
R8709	T13447	T13444	compound	EF,128R
R871	T1658	T1657	compound	TACC,genes
R8710	T13448	T13444	punct	/,128R
R8711	T13449	T13420	punct	", ",ladder
R8712	T13450	T13451	dep	Lane,X1R
R8713	T13451	T13420	dep	X1R,ladder
R8714	T13452	T13450	nummod	6,Lane
R8715	T13453	T13451	compound	X3F,X1R
R8716	T13454	T13451	punct	/,X1R
R8717	T13455	T13420	punct	", ",ladder
R8718	T13456	T13457	dep	Lane,BX647R
R8719	T13457	T13420	dep	BX647R,ladder
R872	T1659	T1651	prep	in,identified
R8720	T13458	T13456	nummod	7,Lane
R8721	T13459	T13457	punct	: ,BX647R
R8722	T13460	T13457	compound	X3F,BX647R
R8723	T13461	T13457	punct	/,BX647R
R8724	T13462	T13420	punct	", ",ladder
R8725	T13463	T13464	dep	Lane,6SPR
R8726	T13464	T13420	dep	6SPR,ladder
R8727	T13465	T13463	nummod	8,Lane
R8728	T13466	T13464	punct	: ,6SPR
R8729	T13467	T13464	compound	X3F,6SPR
R873	T1660	T1659	pobj	representatives,in
R8730	T13468	T13464	punct	/,6SPR
R8731	T13469	T13420	punct	", ",ladder
R8732	T13470	T13471	dep	Lane,1DR
R8733	T13471	T13420	dep	1DR,ladder
R8734	T13472	T13470	nummod	9,Lane
R8735	T13473	T13471	punct	: ,1DR
R8736	T13474	T13471	compound	X3F,1DR
R8737	T13475	T13471	punct	/,1DR
R8738	T13476	T13420	punct	", ",ladder
R8739	T13477	T13478	dep	Lane,128R
R874	T1661	T1660	prep	of,representatives
R8740	T13478	T13420	dep	128R,ladder
R8741	T13479	T13477	nummod	10,Lane
R8742	T13480	T13478	punct	", ",128R
R8743	T13481	T13478	compound	X3F,128R
R8744	T13482	T13478	punct	/,128R
R8745	T13483	T13420	punct	", ",ladder
R8746	T13484	T13485	dep	Lane,X1R
R8747	T13485	T13420	dep	X1R,ladder
R8748	T13486	T13484	nummod	11,Lane
R8749	T13487	T13485	punct	: ,X1R
R875	T1662	T1663	nummod	five,clades
R8750	T13488	T13485	compound	1DF,X1R
R8751	T13489	T13485	punct	/,X1R
R8752	T13490	T13420	punct	", ",ladder
R8753	T13491	T13492	dep	Lane,BX647R
R8754	T13492	T13420	dep	BX647R,ladder
R8755	T13493	T13491	nummod	12,Lane
R8756	T13494	T13492	punct	: ,BX647R
R8757	T13495	T13492	compound	1DF,BX647R
R8758	T13496	T13492	punct	/,BX647R
R8759	T13497	T13420	punct	", ",ladder
R876	T1663	T1661	pobj	clades,of
R8760	T13498	T13499	dep	Lane,6SPR
R8761	T13499	T13420	dep	6SPR,ladder
R8762	T13500	T13498	nummod	13,Lane
R8763	T13501	T13499	punct	: ,6SPR
R8764	T13502	T13499	compound	1DF,6SPR
R8765	T13503	T13499	punct	/,6SPR
R8766	T13504	T13420	punct	", ",ladder
R8767	T13505	T13506	dep	Lane,1DR
R8768	T13506	T13420	dep	1DR,ladder
R8769	T13507	T13505	nummod	14,Lane
R877	T1664	T1663	amod	major,clades
R8770	T13508	T13506	punct	: ,1DR
R8771	T13509	T13506	compound	1DF,1DR
R8772	T13510	T13506	punct	/,1DR
R8773	T13511	T13420	punct	", ",ladder
R8774	T13512	T13513	dep	Lane,128R
R8775	T13513	T13420	dep	128R,ladder
R8776	T13514	T13512	nummod	15,Lane
R8777	T13515	T13513	punct	: ,128R
R8778	T13516	T13513	compound	1DF,128R
R8779	T13517	T13513	punct	/,128R
R878	T1665	T1666	advmod	phylogenetically,distinct
R8780	T13518	T13420	punct	", ",ladder
R8781	T13519	T13420	dep	Lane,ladder
R8782	T13520	T13519	nummod	16,Lane
R8783	T13521	T13420	punct	: ,ladder
R8784	T13522	T13420	nmod	Biorad,ladder
R8785	T13523	T13524	nummod	1,kb+
R8786	T13524	T13525	compound	kb+,Size
R8787	T13525	T13420	compound	Size,ladder
R8788	T13526	T13420	punct	.,ladder
R879	T1666	T1663	amod	distinct,clades
R8791	T13617	T13618	amod	Functional,evolution
R8792	T13619	T13618	prep	of,evolution
R8793	T13620	T13621	det	the,proteins
R8794	T13621	T13619	pobj	proteins,of
R8795	T13622	T13621	compound	TACC,proteins
R8796	T13623	T13618	acl	modeled,evolution
R8797	T13624	T13623	prep	in,modeled
R8798	T13625	T13626	compound	C.,elegans
R8799	T13626	T13624	pobj	elegans,in
R880	T1667	T1651	punct	.,identified
R8800	T13627	T13626	cc	and,elegans
R8801	T13628	T13629	compound	D.,melanogaster
R8802	T13629	T13626	conj	melanogaster,elegans
R8803	T13630	T13618	punct	.,evolution
R8804	T13632	T13633	punct	(,A
R8805	T13633	T13634	meta	A,shows
R8806	T13635	T13633	punct	),A
R8807	T13636	T13633	punct	.,A
R8808	T13637	T13638	compound	C.,elegans
R8809	T13638	T13639	compound	elegans,map
R881	T1669	T1670	advmod	Where,possible
R8810	T13639	T13634	nsubj	map,shows
R8811	T13640	T13639	compound	interaction,map
R8812	T13641	T13642	advmod	empirically,defined
R8813	T13642	T13643	amod	defined,interactions
R8814	T13643	T13634	dobj	interactions,shows
R8815	T13644	T13643	prep	of,interactions
R8816	T13645	T13644	pobj	ceTAC,of
R8817	T13646	T13643	punct	", ",interactions
R8818	T13647	T13643	cc	and,interactions
R8819	T13648	T13649	amod	extrapolated,interactions
R882	T1670	T1671	advcl	possible,confirmed
R8820	T13649	T13643	conj	interactions,interactions
R8821	T13650	T13649	acl	defined,interactions
R8822	T13651	T13650	agent	by,defined
R8823	T13652	T13651	punct	[,by
R8824	T13653	T13651	pobj	28,by
R8825	T13654	T13651	punct	],by
R8826	T13655	T13634	punct	.,shows
R8827	T13657	T13658	punct	(,B
R8828	T13658	T13659	meta	B,binds
R8829	T13660	T13658	punct	),B
R883	T1672	T1671	punct	", ",confirmed
R8830	T13661	T13659	punct	: ,binds
R8831	T13662	T13659	advcl	Using,binds
R8832	T13663	T13664	det	the,database
R8833	T13664	T13662	dobj	database,Using
R8834	T13665	T13664	compound	BIND,database
R8835	T13666	T13667	punct	[,29
R8836	T13667	T13662	parataxis	29,Using
R8837	T13668	T13667	punct	],29
R8838	T13669	T13659	punct	", ",binds
R8839	T13670	T13659	nsubj	DTACC,binds
R884	T1673	T1674	det	the,construction
R8840	T13671	T13659	advmod	directly,binds
R8841	T13672	T13659	prep	to,binds
R8842	T13673	T13672	pobj	TBPH,to
R8843	T13674	T13673	cc	and,TBPH
R8844	T13675	T13673	conj	CG14540,TBPH
R8845	T13676	T13659	punct	", ",binds
R8846	T13677	T13659	cc	and,binds
R8847	T13678	T13659	conj	thus,binds
R8848	T13679	T13678	advmod	indirectly,thus
R8849	T13680	T13678	prep	to,thus
R885	T1674	T1671	nsubjpass	construction,confirmed
R8850	T13681	T13682	compound	chromatin,remodeling
R8851	T13682	T13683	compound	remodeling,complexes
R8852	T13683	T13680	pobj	complexes,to
R8853	T13684	T13683	punct	(,complexes
R8854	T13685	T13686	compound	SWI,SNF
R8855	T13686	T13683	appos	SNF,complexes
R8856	T13687	T13686	punct	/,SNF
R8857	T13688	T13686	cc	and,SNF
R8858	T13689	T13690	compound	histone,acetyltransferases
R8859	T13690	T13686	conj	acetyltransferases,SNF
R886	T1675	T1674	prep	of,construction
R8860	T13691	T13683	punct	),complexes
R8861	T13692	T13683	punct	", ",complexes
R8862	T13693	T13694	compound	DNA,damage
R8863	T13694	T13695	compound	damage,repair
R8864	T13695	T13696	compound	repair,machinery
R8865	T13696	T13683	conj	machinery,complexes
R8866	T13697	T13696	punct	(,machinery
R8867	T13698	T13696	prep	via,machinery
R8868	T13699	T13698	pobj	RAD23,via
R8869	T13700	T13696	punct	),machinery
R887	T1676	T1677	det	the,sequences
R8870	T13701	T13696	punct	", ",machinery
R8871	T13702	T13696	cc	and,machinery
R8872	T13703	T13704	nmod	RNA,splicing
R8873	T13704	T13705	nmod	splicing,machinery
R8874	T13705	T13696	conj	machinery,machinery
R8875	T13706	T13704	punct	", ",splicing
R8876	T13707	T13704	conj	transport,splicing
R8877	T13708	T13707	cc	and,transport
R8878	T13709	T13707	conj	translational,transport
R8879	T13710	T13659	punct	.,binds
R888	T1677	T1675	pobj	sequences,of
R8880	T13712	T13713	punct	(,C
R8881	T13713	T13714	meta	C,suggests
R8882	T13715	T13713	punct	),C
R8883	T13716	T13714	punct	: ,suggests
R8884	T13717	T13718	amod	Predicted,interaction
R8885	T13718	T13719	compound	interaction,map
R8886	T13719	T13714	nsubj	map,suggests
R8887	T13720	T13719	prep	for,map
R8888	T13721	T13722	compound	vertebrate,TACCs
R8889	T13722	T13720	pobj	TACCs,for
R889	T1678	T1677	compound	TACC,sequences
R8890	T13723	T13719	punct	", ",map
R8891	T13724	T13719	prep	based,map
R8892	T13725	T13724	prep	upon,based
R8893	T13726	T13725	pobj	ceTAC,upon
R8894	T13727	T13714	punct	", ",suggests
R8895	T13728	T13729	det	an,interaction
R8896	T13729	T13714	dobj	interaction,suggests
R8897	T13730	T13729	amod	indirect,interaction
R8898	T13731	T13729	prep	with,interaction
R8899	T13732	T13733	det	the,receptor
R890	T1679	T1677	prep	from,sequences
R8900	T13733	T13731	pobj	receptor,with
R8901	T13734	T13733	amod	nuclear,receptor
R8902	T13735	T13733	compound	hormone,receptor
R8903	T13736	T13733	appos	RXRβ,receptor
R8904	T13737	T13714	punct	.,suggests
R8905	T13739	T13740	nsubj	It,is
R8906	T13741	T13740	advmod	also,is
R8907	T13742	T13740	prep	of,is
R8908	T13743	T13742	pobj	interest,of
R8909	T13744	T13745	mark	that,predicts
R891	T1680	T1681	det	these,organisms
R8910	T13745	T13740	ccomp	predicts,is
R8911	T13746	T13745	nsubj	this,predicts
R8912	T13747	T13748	det	a,interaction
R8913	T13748	T13745	dobj	interaction,predicts
R8914	T13749	T13748	amod	functional,interaction
R8915	T13750	T13748	prep	with,interaction
R8916	T13751	T13752	det	the,family
R8917	T13752	T13750	pobj	family,with
R8918	T13753	T13752	compound	LDB,family
R8919	T13754	T13752	punct	", ",family
R892	T1681	T1679	pobj	organisms,from
R8920	T13755	T13756	dep	members,found
R8921	T13756	T13752	relcl	found,family
R8922	T13757	T13755	prep	of,members
R8923	T13758	T13757	pobj	which,of
R8924	T13759	T13756	auxpass	are,found
R8925	T13760	T13756	advmod	also,found
R8926	T13761	T13756	prep	in,found
R8927	T13762	T13763	npadvmod	TACC,containing
R8928	T13763	T13764	amod	containing,segments
R8929	T13764	T13761	pobj	segments,in
R893	T1682	T1671	auxpass	was,confirmed
R8930	T13765	T13764	amod	paralogous,segments
R8931	T13766	T13756	advcl	noted,found
R8932	T13767	T13766	prep	in,noted
R8933	T13768	T13769	nmod	Figs,3
R8934	T13769	T13767	pobj	3,in
R8935	T13770	T13769	nummod	2,3
R8936	T13771	T13769	punct	", ",3
R8937	T13772	T13769	cc	and,3
R8938	T13773	T13774	amod	Additional,file
R8939	T13774	T13769	conj	file,3
R894	T1683	T1671	advmod	also,confirmed
R8940	T13775	T13774	nummod	1,file
R8941	T13776	T13740	punct	.,is
R8942	T13778	T13779	punct	(,D
R8943	T13779	T13780	meta	D,map
R8944	T13781	T13779	punct	),D
R8945	T13782	T13780	punct	: ,map
R8946	T13783	T13780	amod	Predicted,map
R8947	T13784	T13780	compound	TACC,map
R8948	T13785	T13780	compound	interaction,map
R8949	T13786	T13780	prep	based,map
R895	T1684	T1671	agent	by,confirmed
R8950	T13787	T13786	prep	upon,based
R8951	T13788	T13787	pobj	DTACC,upon
R8952	T13789	T13780	punct	.,map
R8953	T13791	T13792	punct	(,E
R8954	T13792	T13793	meta	E,interactions
R8955	T13794	T13792	punct	),E
R8956	T13795	T13793	punct	: ,interactions
R8957	T13796	T13793	compound	Vertebrate,interactions
R8958	T13797	T13793	compound	TACC,interactions
R8959	T13798	T13793	acl	identified,interactions
R896	T1685	T1686	det	the,analysis
R8960	T13799	T13798	prep	to,identified
R8961	T13800	T13799	pobj	date,to
R8962	T13801	T13793	punct	.,interactions
R8963	T13803	T13804	nsubj	?,denotes
R8964	T13805	T13804	dobj	uncertainty,denotes
R8965	T13806	T13805	prep	over,uncertainty
R8966	T13807	T13808	det	the,identity
R8967	T13808	T13806	pobj	identity,over
R8968	T13809	T13808	prep	of,identity
R8969	T13810	T13811	det	a,homologue
R897	T1686	T1684	pobj	analysis,by
R8970	T13811	T13809	pobj	homologue,of
R8971	T13812	T13811	amod	functional,homologue
R8972	T13813	T13811	compound	vertebrate,homologue
R8973	T13814	T13804	punct	.,denotes
R8974	T13816	T13817	prep	In,denotes
R8975	T13818	T13816	pobj	C,In
R8976	T13819	T13818	punct	", ",C
R8977	T13820	T13818	conj	D,C
R8978	T13821	T13820	cc	and,D
R8979	T13822	T13820	conj	E,D
R898	T1687	T1686	prep	of,analysis
R8980	T13823	T13817	punct	", ",denotes
R8981	T13824	T13825	punct	','
R8982	T13825	T13817	nsubj	',denotes
R8983	T13826	T13825	punct	*,'
R8984	T13827	T13828	nummod	one,members
R8985	T13828	T13817	dobj	members,denotes
R8986	T13829	T13827	cc	or,one
R8987	T13830	T13827	conj	more,one
R8988	T13831	T13828	prep	of,members
R8989	T13832	T13833	det	the,family
R899	T1688	T1689	det	the,databases
R8990	T13833	T13831	pobj	family,of
R8991	T13834	T13833	nmod	TACC,family
R8992	T13835	T13834	cc	or,TACC
R8993	T13836	T13837	compound	Aurora,kinase
R8994	T13837	T13834	conj	kinase,TACC
R8995	T13838	T13817	punct	.,denotes
R8996	T13875	T13876	advmod	In,vitro
R8997	T13876	T13877	amod	vitro,interaction
R8998	T13878	T13877	prep	of,interaction
R8999	T13879	T13878	pobj	RXRβ3,of
R900	T1689	T1687	pobj	databases,of
R9000	T13880	T13879	cc	and,RXRβ3
R9001	T13881	T13879	conj	TACC2s,RXRβ3
R9002	T13882	T13877	punct	.,interaction
R9003	T13884	T13885	amod	Top,panel
R9004	T13885	T13886	dep	panel,Autoradiograph
R9005	T13886	T13888	dep	Autoradiograph,input
R9006	T13887	T13886	punct	: ,Autoradiograph
R9007	T13889	T13886	prep	of,Autoradiograph
R9008	T13890	T13891	nummod	12,%
R9009	T13891	T13892	compound	%,SDS
R901	T1690	T1689	compound	cDNA,databases
R9010	T13892	T13893	compound	SDS,gel
R9011	T13893	T13889	pobj	gel,of
R9012	T13894	T13893	compound	polyacrylamide,gel
R9013	T13895	T13886	prep	with,Autoradiograph
R9014	T13896	T13897	advmod	in,vitro
R9015	T13897	T13898	advmod	vitro,translated
R9016	T13898	T13899	amod	translated,construct
R9017	T13899	T13895	pobj	construct,with
R9018	T13900	T13899	compound	RXRβ3,construct
R9019	T13901	T13899	acl	pulled,construct
R902	T1691	T1671	punct	.,confirmed
R9020	T13902	T13901	prt	down,pulled
R9021	T13903	T13901	prep	with,pulled
R9022	T13904	T13905	compound	GST,TACC2
R9023	T13905	T13903	pobj	TACC2,with
R9024	T13906	T13905	punct	-,TACC2
R9025	T13907	T13908	punct	(,Lane
R9026	T13908	T13905	parataxis	Lane,TACC2
R9027	T13909	T13908	nummod	1,Lane
R9028	T13910	T13908	punct	),Lane
R9029	T13911	T13905	cc	or,TACC2
R903	T1693	T1694	amod	Several,sequences
R9030	T13912	T13905	conj	GST,TACC2
R9031	T13913	T13914	punct	(,Lane
R9032	T13914	T13912	parataxis	Lane,GST
R9033	T13915	T13914	nummod	2,Lane
R9034	T13916	T13914	punct	),Lane
R9035	T13917	T13888	punct	;,input
R9036	T13918	T13888	dep	Lane,input
R9037	T13919	T13918	nummod	3,Lane
R9038	T13920	T13888	punct	: ,input
R9039	T13921	T13888	nummod	5,input
R904	T1694	T1696	nsubjpass	sequences,identified
R9040	T13922	T13888	compound	%,input
R9041	T13923	T13888	prep	of,input
R9042	T13924	T13925	advmod	in,vitro
R9043	T13925	T13926	amod	vitro,protein
R9044	T13926	T13923	pobj	protein,of
R9045	T13927	T13926	amod	translated,protein
R9046	T13928	T13929	compound	RXR,β
R9047	T13929	T13926	compound	β,protein
R9048	T13930	T13929	punct	-,β
R9049	T13931	T13888	punct	.,input
R905	T1695	T1694	amod	partial,sequences
R9050	T13933	T13934	amod	Bottom,panels
R9051	T13934	T13936	nsubj	panels,represent
R9052	T13935	T13934	nummod	two,panels
R9053	T13937	T13938	nmod	Coomassie,gels
R9054	T13938	T13936	dobj	gels,represent
R9055	T13939	T13940	amod	blue,stained
R9056	T13940	T13938	amod	stained,gels
R9057	T13941	T13938	prep	of,gels
R9058	T13942	T13943	amod	pull,experiment
R9059	T13943	T13941	pobj	experiment,of
R906	T1697	T1694	prep	in,sequences
R9060	T13944	T13942	prt	down,pull
R9061	T13945	T13943	acl	showing,experiment
R9062	T13946	T13945	dobj	loading,showing
R9063	T13947	T13946	prep	of,loading
R9064	T13948	T13949	compound	GST,TACC2
R9065	T13949	T13947	pobj	TACC2,of
R9066	T13950	T13949	punct	-,TACC2
R9067	T13951	T13949	cc	and,TACC2
R9068	T13952	T13949	conj	GST,TACC2
R9069	T13953	T13936	punct	.,represent
R907	T1698	T1699	amod	other,species
R908	T1699	T1697	pobj	species,in
R909	T1700	T1699	compound	vertebrate,species
R910	T1701	T1699	punct	", ",species
R911	T1702	T1703	det	the,echinodermate
R912	T1703	T1699	appos	echinodermate,species
R913	T1704	T1705	compound	Strongylocentrotus,purpuratus
R914	T1705	T1703	appos	purpuratus,echinodermate
R915	T1706	T1703	cc	and,echinodermate
R916	T1707	T1708	det	the,insect
R917	T1708	T1703	conj	insect,echinodermate
R918	T1709	T1708	compound	protostome,insect
R919	T1710	T1711	compound	Anopheles,gambiae
R920	T1711	T1708	appos	gambiae,insect
R921	T1712	T1696	auxpass	were,identified
R922	T1713	T1696	advmod	also,identified
R923	T1714	T1696	punct	", ",identified
R924	T1715	T1696	advcl	suggesting,identified
R925	T1716	T1717	det	an,conservation
R926	T1717	T1715	dobj	conservation,suggesting
R927	T1718	T1717	amod	ancient,conservation
R928	T1719	T1717	prep	of,conservation
R929	T1720	T1721	det	the,genes
R930	T1721	T1719	pobj	genes,of
R931	T1722	T1721	compound	TACC,genes
R932	T1723	T1717	prep	in,conservation
R933	T1724	T1725	compound	metazoan,lineages
R934	T1725	T1723	pobj	lineages,in
R935	T1726	T1696	punct	.,identified
R936	T1728	T1729	advmod	However,undertaken
R937	T1730	T1729	punct	", ",undertaken
R938	T1731	T1729	prep	due,undertaken
R939	T1732	T1731	pcomp	to,due
R940	T1733	T1734	det	the,infancy
R941	T1734	T1731	pobj	infancy,due
R942	T1735	T1734	amod	relative,infancy
R943	T1736	T1734	prep	of,infancy
R944	T1737	T1738	det	the,projects
R945	T1738	T1736	pobj	projects,of
R946	T1739	T1740	compound	cDNA,genome
R947	T1740	T1738	compound	genome,projects
R948	T1741	T1740	punct	/,genome
R949	T1742	T1738	prep	for,projects
R950	T1743	T1744	det	these,organisms
R951	T1744	T1742	pobj	organisms,for
R952	T1745	T1744	amod	latter,organisms
R953	T1746	T1729	punct	", ",undertaken
R954	T1747	T1748	amod	complete,characterization
R955	T1748	T1729	nsubjpass	characterization,undertaken
R956	T1749	T1748	prep	of,characterization
R957	T1750	T1751	det	these,genes
R958	T1751	T1749	pobj	genes,of
R959	T1752	T1751	compound	TACC,genes
R960	T1753	T1729	aux	could,undertaken
R961	T1754	T1729	neg	not,undertaken
R962	T1755	T1729	auxpass	be,undertaken
R963	T1756	T1729	punct	.,undertaken
R964	T1758	T1759	det	No,conclusion
R965	T1759	T1760	nsubjpass	conclusion,made
R966	T1761	T1760	aux	could,made
R967	T1762	T1760	auxpass	be,made
R968	T1763	T1760	prep	about,made
R969	T1764	T1765	det	the,existence
R970	T1765	T1763	pobj	existence,about
R971	T1766	T1765	prep	of,existence
R972	T1767	T1768	npadvmod	TACC,like
R973	T1768	T1770	amod	like,sequence
R974	T1769	T1768	punct	-,like
R975	T1770	T1766	pobj	sequence,of
R976	T1771	T1765	prep	in,existence
R977	T1772	T1773	amod	non-bilaterian,metazoans
R978	T1773	T1771	pobj	metazoans,in
R979	T1774	T1773	punct	", ",metazoans
R980	T1775	T1776	amod	such,as
R981	T1776	T1773	prep	as,metazoans
R982	T1777	T1776	pobj	Cnidaria,as
R983	T1778	T1777	cc	or,Cnidaria
R984	T1779	T1777	conj	Porifera,Cnidaria
R985	T1780	T1760	punct	", ",made
R986	T1781	T1760	prep	due,made
R987	T1782	T1781	pcomp	to,due
R988	T1783	T1784	det	the,paucity
R989	T1784	T1781	pobj	paucity,due
R990	T1785	T1784	prep	of,paucity
R991	T1786	T1787	compound	sequence,information
R992	T1787	T1785	pobj	information,of
R993	T1788	T1787	prep	for,information
R994	T1789	T1790	det	these,organisms
R995	T1790	T1788	pobj	organisms,for
R996	T1791	T1760	punct	", ",made
R997	T1792	T1760	cc	and,made
R998	T1793	T1794	amod	additional,sequences
R999	T1794	T1796	nsubjpass	sequences,found

PMC:441373 / 2055-51368 JSONTXT 5 Projects

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PMC:441373 / 2055-51368 JSON TXT 5 Projects