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PMC:400732 / 17757-19116 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T5132 0-13 JJ denotes Perseverative
T5134 14-24 JJ denotes behavioral
T5133 25-33 NNS denotes patterns
T5135 34-47 VBD denotes characterized
T5136 48-51 DT denotes the
T5138 52-55 NN denotes D2R
T5139 55-56 SYM denotes -
T5140 56-57 HYPH denotes /
T5141 57-58 SYM denotes -
T5137 59-63 NNS denotes mice
T5142 64-72 JJ denotes relative
T5143 73-75 IN denotes to
T5144 76-79 NN denotes D2R
T5146 79-80 SYM denotes +
T5147 80-81 HYPH denotes /
T5148 81-82 SYM denotes +
T5145 83-87 NNS denotes mice
T5149 88-94 IN denotes during
T5150 95-103 NN denotes reversal
T5152 104-112 NN denotes learning
T5151 113-121 NNS denotes sessions
T5153 122-123 -LRB- denotes (
T5154 123-129 NN denotes Figure
T5155 130-131 CD denotes 4
T5156 131-132 -RRB- denotes )
T5157 132-134 , denotes ,
T5158 134-144 VBD denotes manifested
T5159 145-151 IN denotes during
T5160 152-157 JJ denotes early
T5162 158-166 NN denotes reversal
T5161 167-173 NNS denotes trials
T5163 174-175 -LRB- denotes (
T5164 175-181 NN denotes Figure
T5165 182-183 CD denotes 6
T5166 183-184 -RRB- denotes )
T5167 185-188 CC denotes and
T5168 189-198 VBD denotes persisted
T5169 199-205 IN denotes across
T5170 206-213 JJ denotes several
T5171 214-222 NNS denotes sessions
T5172 223-224 -LRB- denotes (
T5173 224-230 NN denotes Figure
T5174 231-232 CD denotes 7
T5175 232-233 -RRB- denotes )
T5176 233-234 . denotes .
T5177 234-540 sentence denotes These findings are significant because D2R-/- mice respond to food reinforcers and ultimately form and maintain odor-driven S+/S- relationships (a putative D1R-mediated behavior [6]) just as D2R+/+ mice (both groups achieved ≥ 80% discrimination accuracy, the dopamine D1Rs in our mice were not targeted).
T5178 235-240 DT denotes These
T5179 241-249 NNS denotes findings
T5180 250-253 VBP denotes are
T5181 254-265 JJ denotes significant
T5182 266-273 IN denotes because
T5184 274-277 NN denotes D2R
T5186 277-278 SYM denotes -
T5187 278-279 HYPH denotes /
T5188 279-280 SYM denotes -
T5185 281-285 NNS denotes mice
T5183 286-293 VBP denotes respond
T5189 294-296 IN denotes to
T5190 297-301 NN denotes food
T5191 302-313 NNS denotes reinforcers
T5192 314-317 CC denotes and
T5193 318-328 RB denotes ultimately
T5194 329-333 VBP denotes form
T5195 334-337 CC denotes and
T5196 338-346 VBP denotes maintain
T5197 347-351 NN denotes odor
T5199 351-352 HYPH denotes -
T5198 352-358 VBN denotes driven
T5201 359-360 NN denotes S
T5202 360-361 SYM denotes +
T5203 361-362 HYPH denotes /
T5204 362-363 NN denotes S
T5205 363-364 SYM denotes -
T5200 365-378 NNS denotes relationships
T5206 379-380 -LRB- denotes (
T5208 380-381 DT denotes a
T5209 382-390 JJ denotes putative
T5210 391-394 NN denotes D1R
T5212 394-395 HYPH denotes -
T5211 395-403 VBN denotes mediated
T5207 404-412 NN denotes behavior
T5213 413-414 -LRB- denotes [
T5214 414-415 CD denotes 6
T5215 415-416 -RRB- denotes ]
T5216 416-417 -RRB- denotes )
T5217 418-422 RB denotes just
T5218 423-425 IN denotes as
T5219 426-429 NN denotes D2R
T5221 429-430 SYM denotes +
T5222 430-431 HYPH denotes /
T5223 431-432 SYM denotes +
T5220 433-437 NNS denotes mice
T5224 438-439 -LRB- denotes (
T5226 439-443 DT denotes both
T5227 444-450 NNS denotes groups
T5228 451-459 VBD denotes achieved
T5229 460-461 SYM denotes ≥
T5230 462-464 CD denotes 80
T5231 464-465 NN denotes %
T5233 466-480 NN denotes discrimination
T5232 481-489 NN denotes accuracy
T5234 489-491 , denotes ,
T5235 491-494 DT denotes the
T5237 495-503 NN denotes dopamine
T5236 504-508 NNS denotes D1Rs
T5238 509-511 IN denotes in
T5239 512-515 PRP$ denotes our
T5240 516-520 NNS denotes mice
T5241 521-525 VBD denotes were
T5242 526-529 RB denotes not
T5225 530-538 VBN denotes targeted
T5243 538-539 -RRB- denotes )
T5244 539-540 . denotes .
T5245 540-740 sentence denotes A future extension of this study would be to test performance over a fixed number of trials and determine patterns of error rates during acquisition of the discrimination and reversal learning tasks.
T5246 541-542 DT denotes A
T5248 543-549 JJ denotes future
T5247 550-559 NN denotes extension
T5250 560-562 IN denotes of
T5251 563-567 DT denotes this
T5252 568-573 NN denotes study
T5253 574-579 MD denotes would
T5249 580-582 VB denotes be
T5254 583-585 TO denotes to
T5255 586-590 VB denotes test
T5256 591-602 NN denotes performance
T5257 603-607 IN denotes over
T5258 608-609 DT denotes a
T5260 610-615 VBN denotes fixed
T5259 616-622 NN denotes number
T5261 623-625 IN denotes of
T5262 626-632 NNS denotes trials
T5263 633-636 CC denotes and
T5264 637-646 VB denotes determine
T5265 647-655 NNS denotes patterns
T5266 656-658 IN denotes of
T5267 659-664 NN denotes error
T5268 665-670 NNS denotes rates
T5269 671-677 IN denotes during
T5270 678-689 NN denotes acquisition
T5271 690-692 IN denotes of
T5272 693-696 DT denotes the
T5274 697-711 NN denotes discrimination
T5275 712-715 CC denotes and
T5276 716-724 NN denotes reversal
T5277 725-733 NN denotes learning
T5273 734-739 NNS denotes tasks
T5278 739-740 . denotes .
T5279 740-995 sentence denotes This manipulation would control the number of errors based on trials performed to determine if the apparent difference in absolute number of errors demonstrated by the mutant mice (the putative performance deficit) is simply a reflection of extra trials.
T5280 741-745 DT denotes This
T5281 746-758 NN denotes manipulation
T5283 759-764 MD denotes would
T5282 765-772 VB denotes control
T5284 773-776 DT denotes the
T5285 777-783 NN denotes number
T5286 784-786 IN denotes of
T5287 787-793 NNS denotes errors
T5288 794-799 VBN denotes based
T5289 800-802 IN denotes on
T5290 803-809 NNS denotes trials
T5291 810-819 VBN denotes performed
T5292 820-822 TO denotes to
T5293 823-832 VB denotes determine
T5294 833-835 IN denotes if
T5296 836-839 DT denotes the
T5298 840-848 JJ denotes apparent
T5297 849-859 NN denotes difference
T5299 860-862 IN denotes in
T5300 863-871 JJ denotes absolute
T5301 872-878 NN denotes number
T5302 879-881 IN denotes of
T5303 882-888 NNS denotes errors
T5304 889-901 VBN denotes demonstrated
T5305 902-904 IN denotes by
T5306 905-908 DT denotes the
T5308 909-915 JJ denotes mutant
T5307 916-920 NNS denotes mice
T5309 921-922 -LRB- denotes (
T5311 922-925 DT denotes the
T5312 926-934 JJ denotes putative
T5313 935-946 NN denotes performance
T5310 947-954 NN denotes deficit
T5314 954-955 -RRB- denotes )
T5295 956-958 VBZ denotes is
T5315 959-965 RB denotes simply
T5317 966-967 DT denotes a
T5316 968-978 NN denotes reflection
T5318 979-981 IN denotes of
T5319 982-987 JJ denotes extra
T5320 988-994 NNS denotes trials
T5321 994-995 . denotes .
T5322 995-1359 sentence denotes Nonetheless, the inability of D2R-/- mice to disengage from previously established S+/S- contingencies (responding to a discriminative stimulus; Fig. 4) strongly argues that mesolimbic dopamine, and in particular dopamine D2R-mediated signaling, modulates the process of alerting the subject that familiar contingencies are now associated unexpected consequences.
T5323 996-1007 RB denotes Nonetheless
T5325 1007-1009 , denotes ,
T5326 1009-1012 DT denotes the
T5327 1013-1022 NN denotes inability
T5328 1023-1025 IN denotes of
T5329 1026-1029 NN denotes D2R
T5331 1029-1030 SYM denotes -
T5332 1030-1031 HYPH denotes /
T5333 1031-1032 SYM denotes -
T5330 1033-1037 NNS denotes mice
T5334 1038-1040 TO denotes to
T5335 1041-1050 VB denotes disengage
T5336 1051-1055 IN denotes from
T5337 1056-1066 RB denotes previously
T5338 1067-1078 VBN denotes established
T5340 1079-1080 NN denotes S
T5341 1080-1081 SYM denotes +
T5342 1081-1082 HYPH denotes /
T5343 1082-1083 NN denotes S
T5344 1083-1084 HYPH denotes -
T5339 1085-1098 NNS denotes contingencies
T5345 1099-1100 -LRB- denotes (
T5347 1100-1110 VBG denotes responding
T5348 1111-1113 IN denotes to
T5349 1114-1115 DT denotes a
T5351 1116-1130 JJ denotes discriminative
T5350 1131-1139 NN denotes stimulus
T5352 1139-1140 : denotes ;
T5346 1141-1145 NN denotes Fig.
T5353 1146-1147 CD denotes 4
T5354 1147-1148 -RRB- denotes )
T5355 1149-1157 RB denotes strongly
T5324 1158-1164 VBZ denotes argues
T5356 1165-1169 IN denotes that
T5358 1170-1180 JJ denotes mesolimbic
T5359 1181-1189 NN denotes dopamine
T5360 1189-1191 , denotes ,
T5361 1191-1194 CC denotes and
T5362 1195-1197 IN denotes in
T5364 1198-1208 JJ denotes particular
T5365 1209-1217 NN denotes dopamine
T5366 1218-1221 NN denotes D2R
T5368 1221-1222 HYPH denotes -
T5367 1222-1230 VBN denotes mediated
T5363 1231-1240 NN denotes signaling
T5369 1240-1242 , denotes ,
T5357 1242-1251 VBZ denotes modulates
T5370 1252-1255 DT denotes the
T5371 1256-1263 NN denotes process
T5372 1264-1266 IN denotes of
T5373 1267-1275 VBG denotes alerting
T5374 1276-1279 DT denotes the
T5375 1280-1287 NN denotes subject
T5376 1288-1292 IN denotes that
T5378 1293-1301 JJ denotes familiar
T5379 1302-1315 NNS denotes contingencies
T5380 1316-1319 VBP denotes are
T5381 1320-1323 RB denotes now
T5377 1324-1334 VBN denotes associated
T5382 1335-1345 JJ denotes unexpected
T5383 1346-1358 NNS denotes consequences
T5384 1358-1359 . denotes .
R3151 T5181 T5180 acomp significant,are
R3152 T5182 T5183 mark because,respond
R3154 T5183 T5180 advcl respond,are
R3155 T5184 T5185 nmod D2R,mice
R3156 T5185 T5183 nsubj mice,respond
R3158 T5186 T5184 punct -,D2R
R3159 T5187 T5184 punct /,D2R
R3160 T5188 T5184 punct -,D2R
R3162 T5189 T5183 prep to,respond
R3163 T5190 T5191 compound food,reinforcers
R3165 T5191 T5189 pobj reinforcers,to
R3166 T5192 T5183 cc and,respond
R3167 T5193 T5194 advmod ultimately,form
R3169 T5194 T5183 conj form,respond
R3170 T5195 T5194 cc and,form
R3171 T5196 T5194 conj maintain,form
R3172 T5197 T5198 npadvmod odor,driven
R3173 T5198 T5200 amod driven,relationships
R3174 T5199 T5198 punct -,driven
R3176 T5200 T5196 dobj relationships,maintain
R3177 T5201 T5200 nmod S,relationships
R3178 T5202 T5201 punct +,S
R3180 T5203 T5201 punct /,S
R3182 T5204 T5201 appos S,S
R3183 T5205 T5204 punct -,S
R3184 T5206 T5207 punct (,behavior
R3185 T5207 T5200 appos behavior,relationships
R3187 T5208 T5207 det a,behavior
R3188 T5209 T5207 amod putative,behavior
R3190 T5210 T5211 npadvmod D1R,mediated
R3191 T5211 T5207 amod mediated,behavior
R3192 T5212 T5211 punct -,mediated
R3194 T5213 T5214 punct [,6
R3195 T5214 T5196 parataxis 6,maintain
R3196 T5215 T5214 punct ],6
R3198 T5216 T5196 punct ),maintain
R3199 T5217 T5218 advmod just,as
R3200 T5218 T5183 prep as,respond
R3202 T5219 T5220 nmod D2R,mice
R3203 T5220 T5218 pobj mice,as
R3204 T5221 T5219 punct +,D2R
R3206 T5222 T5219 punct /,D2R
R3207 T5223 T5219 punct +,D2R
R3208 T5224 T5225 punct (,targeted
R3211 T5225 T5220 parataxis targeted,mice
R3212 T5226 T5227 det both,groups
R3214 T5227 T5228 nsubj groups,achieved
R3215 T5228 T5225 ccomp achieved,targeted
R3216 T5229 T5230 punct ≥,80
R3218 T5230 T5231 nummod 80,%
R3219 T5231 T5232 compound %,accuracy
R3220 T5232 T5228 dobj accuracy,achieved
R3222 T5233 T5232 compound discrimination,accuracy
R3223 T5234 T5225 punct ", ",targeted
R3224 T5235 T5236 det the,D1Rs
R3225 T5236 T5225 nsubjpass D1Rs,targeted
R3226 T5237 T5236 compound dopamine,D1Rs
R3227 T5238 T5236 prep in,D1Rs
R3229 T5239 T5240 poss our,mice
R3230 T5240 T5238 pobj mice,in
R3231 T5241 T5225 auxpass were,targeted
R3232 T5242 T5225 neg not,targeted
R3234 T5243 T5225 punct ),targeted
R3235 T5244 T5180 punct .,are
R3237 T5246 T5247 det A,extension
R3238 T5247 T5249 nsubj extension,be
R3240 T5248 T5247 amod future,extension
R3241 T5250 T5247 prep of,extension
R3243 T5251 T5252 det this,study
R3244 T5252 T5250 pobj study,of
R3246 T5253 T5249 aux would,be
R3247 T5254 T5255 aux to,test
R3248 T5255 T5249 xcomp test,be
R3250 T5256 T5255 dobj performance,test
R3251 T5257 T5256 prep over,performance
R3252 T5258 T5259 det a,number
R3254 T5259 T5257 pobj number,over
R3255 T5260 T5259 amod fixed,number
R3256 T5261 T5259 prep of,number
R3258 T5262 T5261 pobj trials,of
R3259 T5263 T5255 cc and,test
R3260 T5264 T5255 conj determine,test
R3262 T5265 T5264 dobj patterns,determine
R3263 T5266 T5265 prep of,patterns
R3264 T5267 T5268 compound error,rates
R3266 T5268 T5266 pobj rates,of
R3267 T5269 T5264 prep during,determine
R3268 T5270 T5269 pobj acquisition,during
R3270 T5271 T5270 prep of,acquisition
R3271 T5272 T5273 det the,tasks
R3273 T5273 T5271 pobj tasks,of
R3274 T5274 T5273 nmod discrimination,tasks
R3275 T5275 T5274 cc and,discrimination
R3276 T5276 T5274 conj reversal,discrimination
R3277 T5277 T5273 compound learning,tasks
R3278 T5278 T5249 punct .,be
R3279 T5280 T5281 det This,manipulation
R3280 T5281 T5282 nsubj manipulation,control
R3281 T5283 T5282 aux would,control
R3282 T5284 T5285 det the,number
R3284 T5285 T5282 dobj number,control
R3288 T5286 T5285 prep of,number
R3289 T5287 T5286 pobj errors,of
R3291 T5288 T5282 prep based,control
R3292 T5289 T5288 prep on,based
R3293 T5290 T5289 pobj trials,on
R3295 T5291 T5290 acl performed,trials
R3296 T5292 T5293 aux to,determine
R3297 T5293 T5282 advcl determine,control
R3299 T5294 T5295 mark if,is
R3300 T5295 T5293 ccomp is,determine
R3301 T5296 T5297 det the,difference
R3303 T5297 T5295 nsubj difference,is
R3304 T5298 T5297 amod apparent,difference
R3305 T5299 T5297 prep in,difference
R3307 T5300 T5301 amod absolute,number
R3308 T5301 T5299 pobj number,in
R3309 T5302 T5301 prep of,number
R3311 T5303 T5302 pobj errors,of
R3312 T5304 T5297 acl demonstrated,difference
R3313 T5305 T5304 agent by,demonstrated
R3315 T5306 T5307 det the,mice
R3316 T5307 T5305 pobj mice,by
R3317 T5308 T5307 amod mutant,mice
R3319 T5309 T5310 punct (,deficit
R3320 T5310 T5297 appos deficit,difference
R3321 T5311 T5310 det the,deficit
R3323 T5312 T5310 amod putative,deficit
R3324 T5313 T5310 compound performance,deficit
R3325 T5314 T5310 punct ),deficit
R3326 T5315 T5316 advmod simply,reflection
R3327 T5316 T5295 attr reflection,is
R3328 T5317 T5316 det a,reflection
R3329 T5132 T5133 amod Perseverative,patterns
R3330 T5318 T5316 prep of,reflection
R3331 T5319 T5320 amod extra,trials
R3332 T5320 T5318 pobj trials,of
R3333 T5321 T5282 punct .,control
R3334 T5133 T5135 nsubj patterns,characterized
R3335 T5323 T5324 advmod Nonetheless,argues
R3336 T5134 T5133 amod behavioral,patterns
R3337 T5136 T5137 det the,mice
R3338 T5325 T5324 punct ", ",argues
R3339 T5326 T5327 det the,inability
R3340 T5137 T5135 dobj mice,characterized
R3341 T5327 T5324 nsubj inability,argues
R3342 T5138 T5137 nmod D2R,mice
R3343 T5328 T5327 prep of,inability
R3344 T5329 T5330 nmod D2R,mice
R3345 T5330 T5328 pobj mice,of
R3346 T5331 T5329 punct -,D2R
R3347 T5139 T5138 punct -,D2R
R3348 T5332 T5329 punct /,D2R
R3349 T5333 T5329 punct -,D2R
R3350 T5140 T5138 punct /,D2R
R3351 T5334 T5335 aux to,disengage
R3352 T5335 T5327 acl disengage,inability
R3353 T5336 T5335 prep from,disengage
R3354 T5141 T5138 punct -,D2R
R3355 T5337 T5338 advmod previously,established
R3356 T5338 T5339 amod established,contingencies
R3357 T5142 T5137 amod relative,mice
R3358 T5339 T5336 pobj contingencies,from
R3359 T5340 T5339 nmod S,contingencies
R3360 T5341 T5340 punct +,S
R3361 T5342 T5340 punct /,S
R3362 T5143 T5142 prep to,relative
R3363 T5343 T5340 appos S,S
R3364 T5344 T5343 punct -,S
R3365 T5144 T5145 nmod D2R,mice
R3366 T5345 T5346 punct (,Fig.
R3367 T5346 T5327 parataxis Fig.,inability
R3368 T5347 T5346 advcl responding,Fig.
R3369 T5145 T5143 pobj mice,to
R3370 T5348 T5347 prep to,responding
R3371 T5349 T5350 det a,stimulus
R3372 T5350 T5348 pobj stimulus,to
R3373 T5146 T5144 punct +,D2R
R3374 T5351 T5350 amod discriminative,stimulus
R3375 T5352 T5346 punct ;,Fig.
R3376 T5353 T5346 nummod 4,Fig.
R3377 T5147 T5144 punct /,D2R
R3378 T5354 T5346 punct ),Fig.
R3379 T5355 T5324 advmod strongly,argues
R3380 T5356 T5357 mark that,modulates
R3381 T5357 T5324 ccomp modulates,argues
R3382 T5358 T5359 amod mesolimbic,dopamine
R3383 T5359 T5357 nsubj dopamine,modulates
R3384 T5148 T5144 punct +,D2R
R3385 T5360 T5359 punct ", ",dopamine
R3386 T5361 T5359 cc and,dopamine
R3387 T5362 T5363 prep in,signaling
R3388 T5149 T5135 prep during,characterized
R3389 T5363 T5359 conj signaling,dopamine
R3390 T5364 T5362 amod particular,in
R3391 T5365 T5366 compound dopamine,D2R
R3392 T5150 T5151 compound reversal,sessions
R3393 T5366 T5367 npadvmod D2R,mediated
R3394 T5151 T5149 pobj sessions,during
R3395 T5367 T5363 amod mediated,signaling
R3396 T5368 T5367 punct -,mediated
R3397 T5369 T5357 punct ", ",modulates
R3398 T5152 T5151 compound learning,sessions
R3399 T5370 T5371 det the,process
R3400 T5371 T5357 dobj process,modulates
R3401 T5372 T5371 prep of,process
R3402 T5153 T5154 punct (,Figure
R3403 T5373 T5372 pcomp alerting,of
R3404 T5374 T5375 det the,subject
R3405 T5154 T5135 parataxis Figure,characterized
R3406 T5155 T5154 nummod 4,Figure
R3407 T5375 T5373 dobj subject,alerting
R3408 T5156 T5154 punct ),Figure
R3409 T5376 T5377 mark that,associated
R3410 T5377 T5373 ccomp associated,alerting
R3411 T5157 T5135 punct ", ",characterized
R3412 T5378 T5379 amod familiar,contingencies
R3413 T5379 T5377 nsubjpass contingencies,associated
R3414 T5380 T5377 auxpass are,associated
R3415 T5158 T5135 conj manifested,characterized
R3416 T5381 T5377 advmod now,associated
R3417 T5382 T5383 amod unexpected,consequences
R3418 T5383 T5377 dep consequences,associated
R3419 T5159 T5158 prep during,manifested
R3420 T5384 T5324 punct .,argues
R3422 T5160 T5161 amod early,trials
R3424 T5161 T5159 pobj trials,during
R3428 T5162 T5161 compound reversal,trials
R3429 T5163 T5164 punct (,Figure
R3430 T5164 T5159 parataxis Figure,during
R3434 T5165 T5164 nummod 6,Figure
R3438 T5166 T5164 punct ),Figure
R3442 T5167 T5158 cc and,manifested
R3446 T5168 T5158 conj persisted,manifested
R3450 T5169 T5168 prep across,persisted
R3452 T5170 T5171 amod several,sessions
R3453 T5171 T5169 pobj sessions,across
R3455 T5172 T5173 punct (,Figure
R3457 T5173 T5168 parataxis Figure,persisted
R3461 T5174 T5173 nummod 7,Figure
R3465 T5175 T5173 punct ),Figure
R3467 T5176 T5135 punct .,characterized
R3471 T5178 T5179 det These,findings
R3476 T5179 T5180 nsubj findings,are