PMC:400732 JSON TXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id	Subject	Object	Predicate	Lexical cue
T229	0-8	NN	denotes	Dopamine
T231	0-91	sentence	denotes	Dopamine D2 receptors mediate two-odor discrimination and reversal learning in C57BL/6 mice
T230	9-11	NN	denotes	D2
T232	12-21	NNS	denotes	receptors
T233	22-29	VBP	denotes	mediate
T234	30-33	CD	denotes	two
T236	33-34	HYPH	denotes	-
T235	34-38	NN	denotes	odor
T237	39-53	NN	denotes	discrimination
T238	54-57	CC	denotes	and
T239	58-66	JJ	denotes	reversal
T240	67-75	NN	denotes	learning
T241	76-78	IN	denotes	in
T242	79-84	NN	denotes	C57BL
T244	84-85	HYPH	denotes	/
T245	85-86	CD	denotes	6
T243	87-91	NNS	denotes	mice
T246	91-92	sentence	denotes
T247	102-112	sentence	denotes	Background
T248	102-112	NN	denotes	Background
T249	112-408	sentence	denotes	Dopamine modulation of neuronal signaling in the frontal cortex, midbrain, and striatum is essential for processing and integrating diverse external sensory stimuli and attaching salience to environmental cues that signal causal relationships, thereby guiding goal-directed, adaptable behaviors.
T250	113-121	NN	denotes	Dopamine
T251	122-132	NN	denotes	modulation
T253	133-135	IN	denotes	of
T254	136-144	JJ	denotes	neuronal
T255	145-154	NN	denotes	signaling
T256	155-157	IN	denotes	in
T257	158-161	DT	denotes	the
T259	162-169	JJ	denotes	frontal
T258	170-176	NN	denotes	cortex
T260	176-178	,	denotes	,
T261	178-186	NN	denotes	midbrain
T262	186-188	,	denotes	,
T263	188-191	CC	denotes	and
T264	192-200	NN	denotes	striatum
T252	201-203	VBZ	denotes	is
T265	204-213	JJ	denotes	essential
T266	214-217	IN	denotes	for
T267	218-228	VBG	denotes	processing
T268	229-232	CC	denotes	and
T269	233-244	VBG	denotes	integrating
T270	245-252	JJ	denotes	diverse
T272	253-261	JJ	denotes	external
T273	262-269	JJ	denotes	sensory
T271	270-277	NNS	denotes	stimuli
T274	278-281	CC	denotes	and
T275	282-291	VBG	denotes	attaching
T276	292-300	NN	denotes	salience
T277	301-303	IN	denotes	to
T278	304-317	JJ	denotes	environmental
T279	318-322	NNS	denotes	cues
T280	323-327	WDT	denotes	that
T281	328-334	VBP	denotes	signal
T282	335-341	JJ	denotes	causal
T283	342-355	NNS	denotes	relationships
T284	355-357	,	denotes	,
T285	357-364	RB	denotes	thereby
T286	365-372	VBG	denotes	guiding
T287	373-377	NN	denotes	goal
T289	377-378	HYPH	denotes	-
T288	378-386	VBN	denotes	directed
T291	386-388	,	denotes	,
T292	388-397	JJ	denotes	adaptable
T290	398-407	NNS	denotes	behaviors
T293	407-408	.	denotes	.
T294	408-500	sentence	denotes	At the cellular level, dopamine signaling is mediated through D1-like or D2-like receptors.
T295	409-411	IN	denotes	At
T297	412-415	DT	denotes	the
T299	416-424	JJ	denotes	cellular
T298	425-430	NN	denotes	level
T300	430-432	,	denotes	,
T301	432-440	NN	denotes	dopamine
T302	441-450	NN	denotes	signaling
T303	451-453	VBZ	denotes	is
T296	454-462	VBN	denotes	mediated
T304	463-470	IN	denotes	through
T305	471-473	NN	denotes	D1
T307	473-474	HYPH	denotes	-
T306	474-478	JJ	denotes	like
T309	479-481	CC	denotes	or
T310	482-484	NN	denotes	D2
T312	484-485	HYPH	denotes	-
T311	485-489	JJ	denotes	like
T308	490-499	NNS	denotes	receptors
T313	499-500	.	denotes	.
T314	500-673	sentence	denotes	Although a role for D1-like receptors in a variety of goal-directed behaviors has been identified, an explicit involvement of D2 receptors has not been clearly established.
T315	501-509	IN	denotes	Although
T317	510-511	DT	denotes	a
T318	512-516	NN	denotes	role
T319	517-520	IN	denotes	for
T320	521-523	NN	denotes	D1
T322	523-524	HYPH	denotes	-
T321	524-528	JJ	denotes	like
T323	529-538	NNS	denotes	receptors
T324	539-541	IN	denotes	in
T325	542-543	DT	denotes	a
T326	544-551	NN	denotes	variety
T327	552-554	IN	denotes	of
T328	555-559	NN	denotes	goal
T330	559-560	HYPH	denotes	-
T329	560-568	VBN	denotes	directed
T331	569-578	NNS	denotes	behaviors
T332	579-582	VBZ	denotes	has
T333	583-587	VBN	denotes	been
T316	588-598	VBN	denotes	identified
T335	598-600	,	denotes	,
T336	600-602	DT	denotes	an
T338	603-611	JJ	denotes	explicit
T337	612-623	NN	denotes	involvement
T339	624-626	IN	denotes	of
T340	627-629	NN	denotes	D2
T341	630-639	NNS	denotes	receptors
T342	640-643	VBZ	denotes	has
T343	644-647	RB	denotes	not
T344	648-652	VBN	denotes	been
T345	653-660	RB	denotes	clearly
T334	661-672	VBN	denotes	established
T346	672-673	.	denotes	.
T347	673-1110	sentence	denotes	To determine whether dopamine D2 receptor-mediated signaling contributes to associative and reversal learning, we compared C57Bl/6J mice that completely lack functional dopamine D2 receptors to wild-type mice with respect to their ability to attach appropriate salience to external stimuli (stimulus discrimination) and disengage from inappropriate behavioral strategies when reinforcement contingencies change (e.g. reversal learning).
T348	674-676	TO	denotes	To
T349	677-686	VB	denotes	determine
T351	687-694	IN	denotes	whether
T353	695-703	NN	denotes	dopamine
T354	704-706	NN	denotes	D2
T355	707-715	NN	denotes	receptor
T357	715-716	HYPH	denotes	-
T356	716-724	VBN	denotes	mediated
T358	725-734	NN	denotes	signaling
T352	735-746	VBZ	denotes	contributes
T359	747-749	IN	denotes	to
T360	750-761	JJ	denotes	associative
T362	762-765	CC	denotes	and
T363	766-774	JJ	denotes	reversal
T361	775-783	NN	denotes	learning
T364	783-785	,	denotes	,
T365	785-787	PRP	denotes	we
T350	788-796	VBD	denotes	compared
T366	797-802	NN	denotes	C57Bl
T368	802-803	HYPH	denotes	/
T367	803-805	NN	denotes	6J
T369	806-810	NNS	denotes	mice
T370	811-815	WDT	denotes	that
T372	816-826	RB	denotes	completely
T371	827-831	VBP	denotes	lack
T373	832-842	JJ	denotes	functional
T375	843-851	NN	denotes	dopamine
T376	852-854	NN	denotes	D2
T374	855-864	NNS	denotes	receptors
T377	865-867	IN	denotes	to
T378	868-872	JJ	denotes	wild
T380	872-873	HYPH	denotes	-
T379	873-877	NN	denotes	type
T381	878-882	NNS	denotes	mice
T382	883-887	IN	denotes	with
T383	888-895	NN	denotes	respect
T384	896-898	IN	denotes	to
T385	899-904	PRP$	denotes	their
T386	905-912	NN	denotes	ability
T387	913-915	TO	denotes	to
T388	916-922	VB	denotes	attach
T389	923-934	JJ	denotes	appropriate
T390	935-943	NN	denotes	salience
T391	944-946	IN	denotes	to
T392	947-955	JJ	denotes	external
T393	956-963	NNS	denotes	stimuli
T394	964-965	-LRB-	denotes	(
T396	965-973	NN	denotes	stimulus
T395	974-988	NN	denotes	discrimination
T397	988-989	-RRB-	denotes	)
T398	990-993	CC	denotes	and
T399	994-1003	VB	denotes	disengage
T400	1004-1008	IN	denotes	from
T401	1009-1022	JJ	denotes	inappropriate
T403	1023-1033	JJ	denotes	behavioral
T402	1034-1044	NNS	denotes	strategies
T404	1045-1049	WRB	denotes	when
T406	1050-1063	NN	denotes	reinforcement
T407	1064-1077	NNS	denotes	contingencies
T405	1078-1084	VBP	denotes	change
T408	1085-1086	-LRB-	denotes	(
T410	1086-1090	FW	denotes	e.g.
T411	1091-1099	NN	denotes	reversal
T409	1100-1108	NN	denotes	learning
T412	1108-1109	-RRB-	denotes	)
T413	1109-1110	.	denotes	.
T414	1110-1119	sentence	denotes	Results
T415	1112-1119	NNS	denotes	Results
T416	1119-1289	sentence	denotes	Mildly food-deprived female wild-type and dopamine D2 receptor deficient mice rapidly learned to retrieve and consume visible food reinforcers from a small plastic dish.
T417	1120-1126	RB	denotes	Mildly
T419	1127-1131	NN	denotes	food
T420	1131-1132	HYPH	denotes	-
T418	1132-1140	VBN	denotes	deprived
T422	1141-1147	JJ	denotes	female
T423	1148-1152	JJ	denotes	wild
T425	1152-1153	HYPH	denotes	-
T424	1153-1157	NN	denotes	type
T426	1158-1161	CC	denotes	and
T427	1162-1170	NN	denotes	dopamine
T429	1171-1173	NN	denotes	D2
T428	1174-1182	NN	denotes	receptor
T430	1183-1192	JJ	denotes	deficient
T421	1193-1197	NNS	denotes	mice
T432	1198-1205	RB	denotes	rapidly
T431	1206-1213	VBN	denotes	learned
T433	1214-1216	TO	denotes	to
T434	1217-1225	VB	denotes	retrieve
T435	1226-1229	CC	denotes	and
T436	1230-1237	VB	denotes	consume
T437	1238-1245	JJ	denotes	visible
T439	1246-1250	NN	denotes	food
T438	1251-1262	NNS	denotes	reinforcers
T440	1263-1267	IN	denotes	from
T441	1268-1269	DT	denotes	a
T443	1270-1275	JJ	denotes	small
T444	1276-1283	JJ	denotes	plastic
T442	1284-1288	NN	denotes	dish
T445	1288-1289	.	denotes	.
T446	1289-1428	sentence	denotes	Furthermore, both genotypes readily learned to dig through the same dish filled with sterile sand in order to locate a buried food pellet.
T447	1290-1301	RB	denotes	Furthermore
T449	1301-1303	,	denotes	,
T450	1303-1307	DT	denotes	both
T451	1308-1317	NNS	denotes	genotypes
T452	1318-1325	RB	denotes	readily
T448	1326-1333	VBD	denotes	learned
T453	1334-1336	TO	denotes	to
T454	1337-1340	VB	denotes	dig
T455	1341-1348	IN	denotes	through
T456	1349-1352	DT	denotes	the
T458	1353-1357	JJ	denotes	same
T457	1358-1362	NN	denotes	dish
T459	1363-1369	VBN	denotes	filled
T460	1370-1374	IN	denotes	with
T461	1375-1382	JJ	denotes	sterile
T462	1383-1387	NN	denotes	sand
T463	1388-1390	IN	denotes	in
T464	1391-1396	NN	denotes	order
T465	1397-1399	TO	denotes	to
T466	1400-1406	VB	denotes	locate
T467	1407-1408	DT	denotes	a
T469	1409-1415	JJ	denotes	buried
T470	1416-1420	NN	denotes	food
T468	1421-1427	NN	denotes	pellet
T471	1427-1428	.	denotes	.
T472	1428-1691	sentence	denotes	However, the dopamine D2 receptor deficient mice required significantly more trials than wild-type mice to discriminate between two dishes, each filled with a different scented sand, and to associate one of the two odors with the presence of a reinforcer (food).
T473	1429-1436	RB	denotes	However
T475	1436-1438	,	denotes	,
T476	1438-1441	DT	denotes	the
T478	1442-1450	NN	denotes	dopamine
T479	1451-1453	NN	denotes	D2
T480	1454-1462	NN	denotes	receptor
T481	1463-1472	JJ	denotes	deficient
T477	1473-1477	NNS	denotes	mice
T474	1478-1486	VBD	denotes	required
T482	1487-1500	RB	denotes	significantly
T483	1501-1505	JJR	denotes	more
T484	1506-1512	NNS	denotes	trials
T485	1513-1517	IN	denotes	than
T486	1518-1522	JJ	denotes	wild
T488	1522-1523	HYPH	denotes	-
T487	1523-1527	NN	denotes	type
T489	1528-1532	NNS	denotes	mice
T490	1533-1535	TO	denotes	to
T491	1536-1548	VB	denotes	discriminate
T492	1549-1556	IN	denotes	between
T493	1557-1560	CD	denotes	two
T494	1561-1567	NNS	denotes	dishes
T495	1567-1569	,	denotes	,
T496	1569-1573	DT	denotes	each
T497	1574-1580	VBN	denotes	filled
T498	1581-1585	IN	denotes	with
T499	1586-1587	DT	denotes	a
T501	1588-1597	JJ	denotes	different
T502	1598-1605	VBN	denotes	scented
T500	1606-1610	NN	denotes	sand
T503	1610-1612	,	denotes	,
T504	1612-1615	CC	denotes	and
T505	1616-1618	TO	denotes	to
T506	1619-1628	VB	denotes	associate
T507	1629-1632	CD	denotes	one
T508	1633-1635	IN	denotes	of
T509	1636-1639	DT	denotes	the
T511	1640-1643	CD	denotes	two
T510	1644-1649	NNS	denotes	odors
T512	1650-1654	IN	denotes	with
T513	1655-1658	DT	denotes	the
T514	1659-1667	NN	denotes	presence
T515	1668-1670	IN	denotes	of
T516	1671-1672	DT	denotes	a
T517	1673-1683	NN	denotes	reinforcer
T518	1684-1685	-LRB-	denotes	(
T519	1685-1689	NN	denotes	food
T520	1689-1690	-RRB-	denotes	)
T521	1690-1691	.	denotes	.
T522	1691-1861	sentence	denotes	In addition, the dopamine D2 receptor deficient mice repeatedly fail to alter their response patterns during reversal trials where the reinforcement rules were inverted.
T523	1692-1694	IN	denotes	In
T525	1695-1703	NN	denotes	addition
T526	1703-1705	,	denotes	,
T527	1705-1708	DT	denotes	the
T529	1709-1717	NN	denotes	dopamine
T530	1718-1720	NN	denotes	D2
T531	1721-1729	NN	denotes	receptor
T532	1730-1739	JJ	denotes	deficient
T528	1740-1744	NNS	denotes	mice
T533	1745-1755	RB	denotes	repeatedly
T524	1756-1760	VBP	denotes	fail
T534	1761-1763	TO	denotes	to
T535	1764-1769	VB	denotes	alter
T536	1770-1775	PRP$	denotes	their
T538	1776-1784	NN	denotes	response
T537	1785-1793	NNS	denotes	patterns
T539	1794-1800	IN	denotes	during
T540	1801-1809	NN	denotes	reversal
T541	1810-1816	NNS	denotes	trials
T542	1817-1822	WRB	denotes	where
T544	1823-1826	DT	denotes	the
T546	1827-1840	NN	denotes	reinforcement
T545	1841-1846	NNS	denotes	rules
T547	1847-1851	VBD	denotes	were
T543	1852-1860	VBN	denotes	inverted
T548	1860-1861	.	denotes	.
T549	1861-1874	sentence	denotes	Conclusions
T550	1863-1874	NNS	denotes	Conclusions
T551	1874-2077	sentence	denotes	Inbred C57Bl/6J mice that develop in the complete absence of functional dopamine D2 receptors are capable of olfaction but display an impaired ability to acquire odor-driven reinforcement contingencies.
T552	1875-1881	JJ	denotes	Inbred
T554	1882-1887	NN	denotes	C57Bl
T556	1887-1888	HYPH	denotes	/
T555	1888-1890	NN	denotes	6J
T553	1891-1895	NNS	denotes	mice
T558	1896-1900	WDT	denotes	that
T559	1901-1908	VBP	denotes	develop
T560	1909-1911	IN	denotes	in
T561	1912-1915	DT	denotes	the
T563	1916-1924	JJ	denotes	complete
T562	1925-1932	NN	denotes	absence
T564	1933-1935	IN	denotes	of
T565	1936-1946	JJ	denotes	functional
T567	1947-1955	NN	denotes	dopamine
T568	1956-1958	NN	denotes	D2
T566	1959-1968	NNS	denotes	receptors
T557	1969-1972	VBP	denotes	are
T569	1973-1980	JJ	denotes	capable
T570	1981-1983	IN	denotes	of
T571	1984-1993	NN	denotes	olfaction
T572	1994-1997	CC	denotes	but
T573	1998-2005	VBP	denotes	display
T574	2006-2008	DT	denotes	an
T576	2009-2017	JJ	denotes	impaired
T575	2018-2025	NN	denotes	ability
T577	2026-2028	TO	denotes	to
T578	2029-2036	VB	denotes	acquire
T579	2037-2041	NN	denotes	odor
T581	2041-2042	HYPH	denotes	-
T580	2042-2048	VBN	denotes	driven
T583	2049-2062	NN	denotes	reinforcement
T582	2063-2076	NNS	denotes	contingencies
T584	2076-2077	.	denotes	.
T585	2077-2272	sentence	denotes	Furthermore, the ability of dopamine D2 receptor deficient mice to adjust their responding to a previously reinforced stimulus when unexpected outcomes are encountered is significantly impaired.
T586	2078-2089	RB	denotes	Furthermore
T588	2089-2091	,	denotes	,
T589	2091-2094	DT	denotes	the
T590	2095-2102	NN	denotes	ability
T591	2103-2105	IN	denotes	of
T592	2106-2114	NN	denotes	dopamine
T594	2115-2117	NN	denotes	D2
T593	2118-2126	NN	denotes	receptor
T595	2127-2136	JJ	denotes	deficient
T596	2137-2141	NNS	denotes	mice
T597	2142-2144	TO	denotes	to
T598	2145-2151	VB	denotes	adjust
T599	2152-2157	PRP$	denotes	their
T600	2158-2168	NN	denotes	responding
T601	2169-2171	IN	denotes	to
T602	2172-2173	DT	denotes	a
T604	2174-2184	RB	denotes	previously
T605	2185-2195	VBN	denotes	reinforced
T603	2196-2204	NN	denotes	stimulus
T606	2205-2209	WRB	denotes	when
T608	2210-2220	JJ	denotes	unexpected
T609	2221-2229	NNS	denotes	outcomes
T610	2230-2233	VBP	denotes	are
T607	2234-2245	VBN	denotes	encountered
T587	2246-2248	VBZ	denotes	is
T611	2249-2262	RB	denotes	significantly
T612	2263-2271	JJ	denotes	impaired
T613	2271-2272	.	denotes	.
T614	2272-2483	sentence	denotes	These findings suggest that signaling mediated by the dopamine D2 receptor is important for regulating associative and reversal learning and may have implications for the treatment of human attention disorders.
T615	2273-2278	DT	denotes	These
T616	2279-2287	NNS	denotes	findings
T617	2288-2295	VBP	denotes	suggest
T618	2296-2300	IN	denotes	that
T620	2301-2310	NN	denotes	signaling
T621	2311-2319	VBN	denotes	mediated
T622	2320-2322	IN	denotes	by
T623	2323-2326	DT	denotes	the
T625	2327-2335	NN	denotes	dopamine
T626	2336-2338	NN	denotes	D2
T624	2339-2347	NN	denotes	receptor
T619	2348-2350	VBZ	denotes	is
T627	2351-2360	JJ	denotes	important
T628	2361-2364	IN	denotes	for
T629	2365-2375	VBG	denotes	regulating
T630	2376-2387	JJ	denotes	associative
T632	2388-2391	CC	denotes	and
T633	2392-2400	JJ	denotes	reversal
T631	2401-2409	NN	denotes	learning
T634	2410-2413	CC	denotes	and
T635	2414-2417	MD	denotes	may
T636	2418-2422	VB	denotes	have
T637	2423-2435	NNS	denotes	implications
T638	2436-2439	IN	denotes	for
T639	2440-2443	DT	denotes	the
T640	2444-2453	NN	denotes	treatment
T641	2454-2456	IN	denotes	of
T642	2457-2462	JJ	denotes	human
T644	2463-2472	NN	denotes	attention
T643	2473-2482	NNS	denotes	disorders
T645	2482-2483	.	denotes	.
T1116	2496-2509	NN	denotes	Reinforcement
T1118	2509-2510	HYPH	denotes	-
T1117	2510-2518	VBN	denotes	mediated
T1120	2519-2530	JJ	denotes	associative
T1119	2531-2539	NN	denotes	learning
T1122	2539-2541	,	denotes	,
T1123	2541-2543	CC	denotes	or
T1124	2544-2547	DT	denotes	the
T1125	2548-2555	NN	denotes	ability
T1126	2556-2558	TO	denotes	to
T1127	2559-2566	VB	denotes	ascribe
T1128	2567-2580	JJ	denotes	deterministic
T1129	2581-2594	NNS	denotes	relationships
T1130	2595-2602	IN	denotes	between
T1131	2603-2616	JJ	denotes	environmental
T1132	2617-2624	NNS	denotes	stimuli
T1133	2625-2629	WDT	denotes	that
T1134	2630-2636	VBP	denotes	signal
T1135	2637-2640	DT	denotes	the
T1136	2641-2652	NN	denotes	probability
T1137	2653-2655	IN	denotes	of
T1138	2656-2665	VBG	denotes	receiving
T1139	2666-2667	DT	denotes	a
T1141	2668-2675	JJ	denotes	primary
T1140	2676-2686	NN	denotes	reinforcer
T1142	2687-2688	-LRB-	denotes	(
T1143	2688-2692	FW	denotes	e.g.
T1144	2693-2697	NN	denotes	food
T1145	2697-2698	-RRB-	denotes	)
T1146	2698-2700	,	denotes	,
T1147	2700-2703	VBZ	denotes	has
T1148	2704-2708	VBN	denotes	been
T1121	2709-2716	VBN	denotes	divided
T1149	2717-2721	IN	denotes	into
T1150	2722-2723	CD	denotes	3
T1151	2724-2734	NNS	denotes	components
T1152	2735-2737	CC	denotes	or
T1153	2738-2744	NNS	denotes	stages
T1154	2745-2746	-LRB-	denotes	[
T1155	2746-2747	CD	denotes	1
T1156	2747-2748	-RRB-	denotes	]
T1157	2748-2749	.	denotes	.
T1158	2749-2931	sentence	denotes	The first, unlearned stage is the organism's experience with a primary reinforcer that elicits some unlearned/innate physiological response (e.g. palatability of a food or satiety).
T1159	2750-2753	DT	denotes	The
T1161	2754-2759	JJ	denotes	first
T1162	2759-2761	,	denotes	,
T1163	2761-2770	JJ	denotes	unlearned
T1160	2771-2776	NN	denotes	stage
T1164	2777-2779	VBZ	denotes	is
T1165	2780-2783	DT	denotes	the
T1166	2784-2792	NN	denotes	organism
T1168	2792-2794	POS	denotes	's
T1167	2795-2805	NN	denotes	experience
T1169	2806-2810	IN	denotes	with
T1170	2811-2812	DT	denotes	a
T1172	2813-2820	JJ	denotes	primary
T1171	2821-2831	NN	denotes	reinforcer
T1173	2832-2836	WDT	denotes	that
T1174	2837-2844	VBZ	denotes	elicits
T1175	2845-2849	DT	denotes	some
T1177	2850-2859	JJ	denotes	unlearned
T1179	2859-2860	HYPH	denotes	/
T1178	2860-2866	JJ	denotes	innate
T1180	2867-2880	JJ	denotes	physiological
T1176	2881-2889	NN	denotes	response
T1181	2890-2891	-LRB-	denotes	(
T1182	2891-2895	FW	denotes	e.g.
T1183	2896-2908	NN	denotes	palatability
T1184	2909-2911	IN	denotes	of
T1185	2912-2913	DT	denotes	a
T1186	2914-2918	NN	denotes	food
T1187	2919-2921	CC	denotes	or
T1188	2922-2929	NN	denotes	satiety
T1189	2929-2930	-RRB-	denotes	)
T1190	2930-2931	.	denotes	.
T1191	2931-3252	sentence	denotes	The second phase involves the attachment of salience to external stimuli (discriminative stimuli) that signal whether the delivery of a primary reinforcer will or will not occur based on some emitted behavior (e.g. a rodent lever presses for food pellets only when a stimulus light is illuminated in an operant chamber).
T1192	2932-2935	DT	denotes	The
T1194	2936-2942	JJ	denotes	second
T1193	2943-2948	NN	denotes	phase
T1195	2949-2957	VBZ	denotes	involves
T1196	2958-2961	DT	denotes	the
T1197	2962-2972	NN	denotes	attachment
T1198	2973-2975	IN	denotes	of
T1199	2976-2984	NN	denotes	salience
T1200	2985-2987	IN	denotes	to
T1201	2988-2996	JJ	denotes	external
T1202	2997-3004	NNS	denotes	stimuli
T1203	3005-3006	-LRB-	denotes	(
T1204	3006-3020	JJ	denotes	discriminative
T1205	3021-3028	NNS	denotes	stimuli
T1206	3028-3029	-RRB-	denotes	)
T1207	3030-3034	WDT	denotes	that
T1208	3035-3041	VBP	denotes	signal
T1209	3042-3049	IN	denotes	whether
T1211	3050-3053	DT	denotes	the
T1212	3054-3062	NN	denotes	delivery
T1213	3063-3065	IN	denotes	of
T1214	3066-3067	DT	denotes	a
T1216	3068-3075	JJ	denotes	primary
T1215	3076-3086	NN	denotes	reinforcer
T1210	3087-3091	MD	denotes	will
T1217	3092-3094	CC	denotes	or
T1218	3095-3099	MD	denotes	will
T1219	3100-3103	RB	denotes	not
T1220	3104-3109	VB	denotes	occur
T1221	3110-3115	VBN	denotes	based
T1222	3116-3118	IN	denotes	on
T1223	3119-3123	DT	denotes	some
T1225	3124-3131	JJ	denotes	emitted
T1224	3132-3140	NN	denotes	behavior
T1226	3141-3142	-LRB-	denotes	(
T1228	3142-3146	FW	denotes	e.g.
T1229	3147-3148	DT	denotes	a
T1230	3149-3155	NN	denotes	rodent
T1231	3156-3161	NN	denotes	lever
T1227	3162-3169	VBZ	denotes	presses
T1232	3170-3173	IN	denotes	for
T1233	3174-3178	NN	denotes	food
T1234	3179-3186	NNS	denotes	pellets
T1235	3187-3191	RB	denotes	only
T1237	3192-3196	WRB	denotes	when
T1238	3197-3198	DT	denotes	a
T1240	3199-3207	NN	denotes	stimulus
T1239	3208-3213	NN	denotes	light
T1241	3214-3216	VBZ	denotes	is
T1236	3217-3228	VBN	denotes	illuminated
T1242	3229-3231	IN	denotes	in
T1243	3232-3234	DT	denotes	an
T1245	3235-3242	NN	denotes	operant
T1244	3243-3250	NN	denotes	chamber
T1246	3250-3251	-RRB-	denotes	)
T1247	3251-3252	.	denotes	.
T1248	3252-3455	sentence	denotes	Finally, there is the maintenance of associative learning relationships over time (a stimulus light always signifies a food pellet is available subsequent to a lever press) [see refs. [1,2] for review].
T1249	3253-3260	RB	denotes	Finally
T1251	3260-3262	,	denotes	,
T1252	3262-3267	EX	denotes	there
T1250	3268-3270	VBZ	denotes	is
T1253	3271-3274	DT	denotes	the
T1254	3275-3286	NN	denotes	maintenance
T1255	3287-3289	IN	denotes	of
T1256	3290-3301	JJ	denotes	associative
T1257	3302-3310	NN	denotes	learning
T1258	3311-3324	NNS	denotes	relationships
T1259	3325-3329	IN	denotes	over
T1260	3330-3334	NN	denotes	time
T1261	3335-3336	-LRB-	denotes	(
T1263	3336-3337	DT	denotes	a
T1265	3338-3346	NN	denotes	stimulus
T1264	3347-3352	NN	denotes	light
T1266	3353-3359	RB	denotes	always
T1262	3360-3369	VBZ	denotes	signifies
T1267	3370-3371	DT	denotes	a
T1269	3372-3376	NN	denotes	food
T1268	3377-3383	NN	denotes	pellet
T1270	3384-3386	VBZ	denotes	is
T1271	3387-3396	JJ	denotes	available
T1272	3397-3407	JJ	denotes	subsequent
T1273	3408-3410	IN	denotes	to
T1274	3411-3412	DT	denotes	a
T1276	3413-3418	NN	denotes	lever
T1275	3419-3424	NN	denotes	press
T1277	3424-3425	-RRB-	denotes	)
T1278	3426-3427	-LRB-	denotes	[
T1279	3427-3430	VB	denotes	see
T1280	3431-3436	NNS	denotes	refs.
T1282	3437-3438	-LRB-	denotes	[
T1283	3438-3439	CD	denotes	1
T1284	3439-3440	,	denotes	,
T1281	3440-3441	CD	denotes	2
T1285	3441-3442	-RRB-	denotes	]
T1286	3443-3446	IN	denotes	for
T1287	3447-3453	NN	denotes	review
T1288	3453-3454	-RRB-	denotes	]
T1289	3454-3455	.	denotes	.
T1290	3455-3692	sentence	denotes	Berridge and Robinson [1] have proposed that dopamine plays a pivotal role in the second phase of reinforcement-mediated associative learning by molding the "incentive salience" or learned motivational properties of conditioned stimuli.
T1291	3456-3464	NNP	denotes	Berridge
T1293	3465-3468	CC	denotes	and
T1294	3469-3477	NNP	denotes	Robinson
T1295	3478-3479	-LRB-	denotes	[
T1296	3479-3480	CD	denotes	1
T1297	3480-3481	-RRB-	denotes	]
T1298	3482-3486	VBP	denotes	have
T1292	3487-3495	VBN	denotes	proposed
T1299	3496-3500	IN	denotes	that
T1301	3501-3509	NN	denotes	dopamine
T1300	3510-3515	VBZ	denotes	plays
T1302	3516-3517	DT	denotes	a
T1304	3518-3525	JJ	denotes	pivotal
T1303	3526-3530	NN	denotes	role
T1305	3531-3533	IN	denotes	in
T1306	3534-3537	DT	denotes	the
T1308	3538-3544	JJ	denotes	second
T1307	3545-3550	NN	denotes	phase
T1309	3551-3553	IN	denotes	of
T1310	3554-3567	NN	denotes	reinforcement
T1312	3567-3568	HYPH	denotes	-
T1311	3568-3576	VBN	denotes	mediated
T1314	3577-3588	JJ	denotes	associative
T1313	3589-3597	NN	denotes	learning
T1315	3598-3600	IN	denotes	by
T1316	3601-3608	VBG	denotes	molding
T1317	3609-3612	DT	denotes	the
T1319	3613-3614	``	denotes	"
T1320	3614-3623	NN	denotes	incentive
T1318	3624-3632	NN	denotes	salience
T1321	3632-3633	''	denotes	"
T1322	3634-3636	CC	denotes	or
T1323	3637-3644	JJ	denotes	learned
T1325	3645-3657	JJ	denotes	motivational
T1324	3658-3668	NNS	denotes	properties
T1326	3669-3671	IN	denotes	of
T1327	3672-3683	VBN	denotes	conditioned
T1328	3684-3691	NNS	denotes	stimuli
T1329	3691-3692	.	denotes	.
T1330	3692-4084	sentence	denotes	In support of this view are several studies demonstrating that the disruption of dopamine signaling via acute blockade of dopamine receptors with dopamine receptor antagonists [3-9] or 6-OHDA lesions [1,10,11] do not disrupt phase 1, the palatability or primary reinforcing characteristics of a natural reinforcer (e.g. palatability) but disrupt phase 2, the formation of incentive salience.
T1331	3693-3695	IN	denotes	In
T1333	3696-3703	NN	denotes	support
T1334	3704-3706	IN	denotes	of
T1335	3707-3711	DT	denotes	this
T1336	3712-3716	NN	denotes	view
T1332	3717-3720	VBP	denotes	are
T1337	3721-3728	JJ	denotes	several
T1338	3729-3736	NNS	denotes	studies
T1339	3737-3750	VBG	denotes	demonstrating
T1340	3751-3755	IN	denotes	that
T1342	3756-3759	DT	denotes	the
T1343	3760-3770	NN	denotes	disruption
T1344	3771-3773	IN	denotes	of
T1345	3774-3782	NN	denotes	dopamine
T1346	3783-3792	NN	denotes	signaling
T1347	3793-3796	IN	denotes	via
T1348	3797-3802	JJ	denotes	acute
T1349	3803-3811	NN	denotes	blockade
T1350	3812-3814	IN	denotes	of
T1351	3815-3823	NN	denotes	dopamine
T1352	3824-3833	NNS	denotes	receptors
T1353	3834-3838	IN	denotes	with
T1354	3839-3847	NN	denotes	dopamine
T1355	3848-3856	NN	denotes	receptor
T1356	3857-3868	NNS	denotes	antagonists
T1357	3869-3870	-LRB-	denotes	[
T1358	3870-3871	CD	denotes	3
T1359	3871-3872	SYM	denotes	-
T1360	3872-3873	CD	denotes	9
T1361	3873-3874	-RRB-	denotes	]
T1362	3875-3877	CC	denotes	or
T1363	3878-3879	CD	denotes	6
T1365	3879-3880	HYPH	denotes	-
T1364	3880-3884	NN	denotes	OHDA
T1366	3885-3892	NNS	denotes	lesions
T1367	3893-3894	-LRB-	denotes	[
T1369	3894-3895	CD	denotes	1
T1370	3895-3896	,	denotes	,
T1371	3896-3898	CD	denotes	10
T1372	3898-3899	,	denotes	,
T1368	3899-3901	CD	denotes	11
T1373	3901-3902	-RRB-	denotes	]
T1374	3903-3905	VBP	denotes	do
T1375	3906-3909	RB	denotes	not
T1341	3910-3917	VB	denotes	disrupt
T1376	3918-3923	NN	denotes	phase
T1377	3924-3925	CD	denotes	1
T1378	3925-3927	,	denotes	,
T1379	3927-3930	DT	denotes	the
T1380	3931-3943	NN	denotes	palatability
T1381	3944-3946	CC	denotes	or
T1382	3947-3954	JJ	denotes	primary
T1384	3955-3966	VBG	denotes	reinforcing
T1383	3967-3982	NNS	denotes	characteristics
T1385	3983-3985	IN	denotes	of
T1386	3986-3987	DT	denotes	a
T1388	3988-3995	JJ	denotes	natural
T1387	3996-4006	NN	denotes	reinforcer
T1389	4007-4008	-LRB-	denotes	(
T1391	4008-4012	FW	denotes	e.g.
T1390	4013-4025	NN	denotes	palatability
T1392	4025-4026	-RRB-	denotes	)
T1393	4027-4030	CC	denotes	but
T1394	4031-4038	VBP	denotes	disrupt
T1395	4039-4044	NN	denotes	phase
T1396	4045-4046	CD	denotes	2
T1397	4046-4048	,	denotes	,
T1398	4048-4051	DT	denotes	the
T1399	4052-4061	NN	denotes	formation
T1400	4062-4064	IN	denotes	of
T1401	4065-4074	NN	denotes	incentive
T1402	4075-4083	NN	denotes	salience
T1403	4083-4084	.	denotes	.
T1404	4084-4277	sentence	denotes	Dopamine signaling is mediated at the cellular level by two major subclasses of G-protein coupled receptors that are referred to as D-1 like (D1aR, D1b/5R) or D-2 like (D2R, D3R, D4R) [12,13].
T1405	4085-4093	NN	denotes	Dopamine
T1406	4094-4103	NN	denotes	signaling
T1408	4104-4106	VBZ	denotes	is
T1407	4107-4115	VBN	denotes	mediated
T1409	4116-4118	IN	denotes	at
T1410	4119-4122	DT	denotes	the
T1412	4123-4131	JJ	denotes	cellular
T1411	4132-4137	NN	denotes	level
T1413	4138-4140	IN	denotes	by
T1414	4141-4144	CD	denotes	two
T1416	4145-4150	JJ	denotes	major
T1415	4151-4161	NNS	denotes	subclasses
T1417	4162-4164	IN	denotes	of
T1418	4165-4166	NN	denotes	G
T1420	4166-4167	HYPH	denotes	-
T1419	4167-4174	NN	denotes	protein
T1421	4175-4182	VBN	denotes	coupled
T1422	4183-4192	NNS	denotes	receptors
T1423	4193-4197	WDT	denotes	that
T1425	4198-4201	VBP	denotes	are
T1424	4202-4210	VBN	denotes	referred
T1426	4211-4213	IN	denotes	to
T1427	4214-4216	IN	denotes	as
T1428	4217-4218	NN	denotes	D
T1430	4218-4219	HYPH	denotes	-
T1431	4219-4220	CD	denotes	1
T1429	4221-4225	JJ	denotes	like
T1432	4226-4227	-LRB-	denotes	(
T1433	4227-4231	NN	denotes	D1aR
T1434	4231-4233	,	denotes	,
T1435	4233-4236	NN	denotes	D1b
T1437	4236-4237	HYPH	denotes	/
T1436	4237-4239	NN	denotes	5R
T1438	4239-4240	-RRB-	denotes	)
T1439	4241-4243	CC	denotes	or
T1440	4244-4245	NN	denotes	D
T1442	4245-4246	HYPH	denotes	-
T1443	4246-4247	CD	denotes	2
T1441	4248-4252	JJ	denotes	like
T1444	4253-4254	-LRB-	denotes	(
T1446	4254-4257	NN	denotes	D2R
T1447	4257-4259	,	denotes	,
T1448	4259-4262	NN	denotes	D3R
T1449	4262-4264	,	denotes	,
T1445	4264-4267	NN	denotes	D4R
T1450	4267-4268	-RRB-	denotes	)
T1451	4269-4270	-LRB-	denotes	[
T1453	4270-4272	CD	denotes	12
T1454	4272-4273	,	denotes	,
T1452	4273-4275	CD	denotes	13
T1455	4275-4276	-RRB-	denotes	]
T1456	4276-4277	.	denotes	.
T1457	4277-4429	sentence	denotes	Although individual genes code for each dopamine receptor subtype, there is considerable pharmacological overlap between D1-like and D2-like receptors.
T1458	4278-4286	IN	denotes	Although
T1460	4287-4297	JJ	denotes	individual
T1461	4298-4303	NNS	denotes	genes
T1459	4304-4308	VBP	denotes	code
T1463	4309-4312	IN	denotes	for
T1464	4313-4317	DT	denotes	each
T1466	4318-4326	NN	denotes	dopamine
T1467	4327-4335	NN	denotes	receptor
T1465	4336-4343	NN	denotes	subtype
T1468	4343-4345	,	denotes	,
T1469	4345-4350	EX	denotes	there
T1462	4351-4353	VBZ	denotes	is
T1470	4354-4366	JJ	denotes	considerable
T1472	4367-4382	JJ	denotes	pharmacological
T1471	4383-4390	NN	denotes	overlap
T1473	4391-4398	IN	denotes	between
T1474	4399-4401	NN	denotes	D1
T1476	4401-4402	HYPH	denotes	-
T1475	4402-4406	JJ	denotes	like
T1478	4407-4410	CC	denotes	and
T1479	4411-4413	NN	denotes	D2
T1481	4413-4414	HYPH	denotes	-
T1480	4414-4418	JJ	denotes	like
T1477	4419-4428	NNS	denotes	receptors
T1482	4428-4429	.	denotes	.
T1483	4429-4599	sentence	denotes	Several studies have used pharmacological manipulations to investigate the contribution of dopamine receptor subtypes in various stages of associative learning [1,2,14].
T1484	4430-4437	JJ	denotes	Several
T1485	4438-4445	NNS	denotes	studies
T1487	4446-4450	VBP	denotes	have
T1486	4451-4455	VBN	denotes	used
T1488	4456-4471	JJ	denotes	pharmacological
T1489	4472-4485	NNS	denotes	manipulations
T1490	4486-4488	TO	denotes	to
T1491	4489-4500	VB	denotes	investigate
T1492	4501-4504	DT	denotes	the
T1493	4505-4517	NN	denotes	contribution
T1494	4518-4520	IN	denotes	of
T1495	4521-4529	NN	denotes	dopamine
T1496	4530-4538	NN	denotes	receptor
T1497	4539-4547	NNS	denotes	subtypes
T1498	4548-4550	IN	denotes	in
T1499	4551-4558	JJ	denotes	various
T1500	4559-4565	NNS	denotes	stages
T1501	4566-4568	IN	denotes	of
T1502	4569-4580	JJ	denotes	associative
T1503	4581-4589	NN	denotes	learning
T1504	4590-4591	-LRB-	denotes	[
T1506	4591-4592	CD	denotes	1
T1507	4592-4593	,	denotes	,
T1508	4593-4594	CD	denotes	2
T1509	4594-4595	,	denotes	,
T1505	4595-4597	CD	denotes	14
T1510	4597-4598	-RRB-	denotes	]
T1511	4598-4599	.	denotes	.
T1512	4599-4967	sentence	denotes	Currently it is held that excitatory dopamine D1Rs mediate the acquisition and expression of several conditioned behaviors involving food reinforcers [e.g. [6,7]] as well as responding for conditioned cues predictive of cocaine delivery [9] – consistent with the interpretation that D1R mediated signaling might modulate the maintenance of stimulus-response outcomes.
T1513	4600-4609	RB	denotes	Currently
T1515	4610-4612	PRP	denotes	it
T1516	4613-4615	VBZ	denotes	is
T1514	4616-4620	VBN	denotes	held
T1517	4621-4625	IN	denotes	that
T1519	4626-4636	JJ	denotes	excitatory
T1521	4637-4645	NN	denotes	dopamine
T1520	4646-4650	NNS	denotes	D1Rs
T1518	4651-4658	VBP	denotes	mediate
T1522	4659-4662	DT	denotes	the
T1523	4663-4674	NN	denotes	acquisition
T1524	4675-4678	CC	denotes	and
T1525	4679-4689	NN	denotes	expression
T1526	4690-4692	IN	denotes	of
T1527	4693-4700	JJ	denotes	several
T1529	4701-4712	JJ	denotes	conditioned
T1528	4713-4722	NNS	denotes	behaviors
T1530	4723-4732	VBG	denotes	involving
T1531	4733-4737	NN	denotes	food
T1532	4738-4749	NNS	denotes	reinforcers
T1533	4750-4751	-LRB-	denotes	[
T1535	4751-4755	FW	denotes	e.g.
T1536	4756-4757	-LRB-	denotes	[
T1537	4757-4758	CD	denotes	6
T1538	4758-4759	,	denotes	,
T1534	4759-4760	CD	denotes	7
T1539	4760-4761	-RRB-	denotes	]
T1540	4761-4762	-RRB-	denotes	]
T1541	4763-4765	RB	denotes	as
T1543	4766-4770	RB	denotes	well
T1542	4771-4773	IN	denotes	as
T1544	4774-4784	VBG	denotes	responding
T1545	4785-4788	IN	denotes	for
T1546	4789-4800	VBN	denotes	conditioned
T1547	4801-4805	NNS	denotes	cues
T1548	4806-4816	JJ	denotes	predictive
T1549	4817-4819	IN	denotes	of
T1550	4820-4827	NN	denotes	cocaine
T1551	4828-4836	NN	denotes	delivery
T1552	4837-4838	-LRB-	denotes	[
T1553	4838-4839	CD	denotes	9
T1554	4839-4840	-RRB-	denotes	]
T1555	4841-4842	:	denotes	–
T1556	4843-4853	JJ	denotes	consistent
T1557	4854-4858	IN	denotes	with
T1558	4859-4862	DT	denotes	the
T1559	4863-4877	NN	denotes	interpretation
T1560	4878-4882	IN	denotes	that
T1562	4883-4886	NN	denotes	D1R
T1563	4887-4895	JJ	denotes	mediated
T1564	4896-4905	NN	denotes	signaling
T1565	4906-4911	MD	denotes	might
T1561	4912-4920	VB	denotes	modulate
T1566	4921-4924	DT	denotes	the
T1567	4925-4936	NN	denotes	maintenance
T1568	4937-4939	IN	denotes	of
T1569	4940-4948	NN	denotes	stimulus
T1571	4948-4949	HYPH	denotes	-
T1570	4949-4957	NN	denotes	response
T1572	4958-4966	NNS	denotes	outcomes
T1573	4966-4967	.	denotes	.
T1574	4967-5301	sentence	denotes	Despite a growing literature demonstrating disrupted associative learning following acute manipulations of dopamine D1R signaling during acquisition of associative learning tasks with food [e.g. [6,7]], the actual contribution of D2R-mediated signaling on acquisition and maintenance of associative learning in rodents is unresolved.
T1575	4968-4975	IN	denotes	Despite
T1577	4976-4977	DT	denotes	a
T1579	4978-4985	VBG	denotes	growing
T1578	4986-4996	NN	denotes	literature
T1580	4997-5010	VBG	denotes	demonstrating
T1581	5011-5020	JJ	denotes	disrupted
T1583	5021-5032	JJ	denotes	associative
T1582	5033-5041	NN	denotes	learning
T1584	5042-5051	VBG	denotes	following
T1585	5052-5057	JJ	denotes	acute
T1586	5058-5071	NNS	denotes	manipulations
T1587	5072-5074	IN	denotes	of
T1588	5075-5083	NN	denotes	dopamine
T1589	5084-5087	NN	denotes	D1R
T1590	5088-5097	NN	denotes	signaling
T1591	5098-5104	IN	denotes	during
T1592	5105-5116	NN	denotes	acquisition
T1593	5117-5119	IN	denotes	of
T1594	5120-5131	JJ	denotes	associative
T1595	5132-5140	NN	denotes	learning
T1596	5141-5146	NNS	denotes	tasks
T1597	5147-5151	IN	denotes	with
T1598	5152-5156	NN	denotes	food
T1599	5157-5158	-LRB-	denotes	[
T1601	5158-5162	FW	denotes	e.g.
T1602	5163-5164	-LRB-	denotes	[
T1603	5164-5165	CD	denotes	6
T1604	5165-5166	,	denotes	,
T1600	5166-5167	CD	denotes	7
T1605	5167-5168	-RRB-	denotes	]
T1606	5168-5169	-RRB-	denotes	]
T1607	5169-5171	,	denotes	,
T1608	5171-5174	DT	denotes	the
T1610	5175-5181	JJ	denotes	actual
T1609	5182-5194	NN	denotes	contribution
T1611	5195-5197	IN	denotes	of
T1612	5198-5201	NN	denotes	D2R
T1614	5201-5202	HYPH	denotes	-
T1613	5202-5210	VBN	denotes	mediated
T1615	5211-5220	NN	denotes	signaling
T1616	5221-5223	IN	denotes	on
T1617	5224-5235	NN	denotes	acquisition
T1618	5236-5239	CC	denotes	and
T1619	5240-5251	NN	denotes	maintenance
T1620	5252-5254	IN	denotes	of
T1621	5255-5266	JJ	denotes	associative
T1622	5267-5275	NN	denotes	learning
T1623	5276-5278	IN	denotes	in
T1624	5279-5286	NNS	denotes	rodents
T1576	5287-5289	VBZ	denotes	is
T1625	5290-5300	JJ	denotes	unresolved
T1626	5300-5301	.	denotes	.
T1627	5301-5648	sentence	denotes	While D2R antagonists have been used in the context of rodent associative learning paradigms, their lack of receptor subtype specificity [13] and motor-disrupting effects [6,8] have prevented a rigorous examination of the actual role this dopamine receptor subtype plays in associative and reversal learning in the context of an operant behavior.
T1628	5302-5307	IN	denotes	While
T1630	5308-5311	NN	denotes	D2R
T1631	5312-5323	NNS	denotes	antagonists
T1632	5324-5328	VBP	denotes	have
T1633	5329-5333	VBN	denotes	been
T1629	5334-5338	VBN	denotes	used
T1635	5339-5341	IN	denotes	in
T1636	5342-5345	DT	denotes	the
T1637	5346-5353	NN	denotes	context
T1638	5354-5356	IN	denotes	of
T1639	5357-5363	NN	denotes	rodent
T1641	5364-5375	JJ	denotes	associative
T1642	5376-5384	NN	denotes	learning
T1640	5385-5394	NNS	denotes	paradigms
T1643	5394-5396	,	denotes	,
T1644	5396-5401	PRP$	denotes	their
T1645	5402-5406	NN	denotes	lack
T1646	5407-5409	IN	denotes	of
T1647	5410-5418	NN	denotes	receptor
T1648	5419-5426	NN	denotes	subtype
T1649	5427-5438	NN	denotes	specificity
T1650	5439-5440	-LRB-	denotes	[
T1651	5440-5442	CD	denotes	13
T1652	5442-5443	-RRB-	denotes	]
T1653	5444-5447	CC	denotes	and
T1654	5448-5453	NN	denotes	motor
T1656	5453-5454	HYPH	denotes	-
T1655	5454-5464	VBG	denotes	disrupting
T1657	5465-5472	NNS	denotes	effects
T1658	5473-5474	-LRB-	denotes	[
T1660	5474-5475	CD	denotes	6
T1661	5475-5476	,	denotes	,
T1659	5476-5477	CD	denotes	8
T1662	5477-5478	-RRB-	denotes	]
T1663	5479-5483	VBP	denotes	have
T1634	5484-5493	VBN	denotes	prevented
T1664	5494-5495	DT	denotes	a
T1666	5496-5504	JJ	denotes	rigorous
T1665	5505-5516	NN	denotes	examination
T1667	5517-5519	IN	denotes	of
T1668	5520-5523	DT	denotes	the
T1670	5524-5530	JJ	denotes	actual
T1669	5531-5535	NN	denotes	role
T1671	5536-5540	DT	denotes	this
T1673	5541-5549	NN	denotes	dopamine
T1674	5550-5558	NN	denotes	receptor
T1672	5559-5566	NN	denotes	subtype
T1675	5567-5572	VBZ	denotes	plays
T1676	5573-5575	IN	denotes	in
T1677	5576-5587	JJ	denotes	associative
T1679	5588-5591	CC	denotes	and
T1680	5592-5600	JJ	denotes	reversal
T1678	5601-5609	NN	denotes	learning
T1681	5610-5612	IN	denotes	in
T1682	5613-5616	DT	denotes	the
T1683	5617-5624	NN	denotes	context
T1684	5625-5627	IN	denotes	of
T1685	5628-5630	DT	denotes	an
T1687	5631-5638	NN	denotes	operant
T1686	5639-5647	NN	denotes	behavior
T1688	5647-5648	.	denotes	.
T1689	5648-5989	sentence	denotes	Past experiments seeking to explore the possible involvement of dopamine D2Rs in associative learning have utilized low to moderate doses of drugs [2,5,6] and site-specific administration [7,9] in order to avoid the confounding effect that locomotor disruption associated with acute D2R blockade can have on learning performance in rodents.
T1690	5649-5653	JJ	denotes	Past
T1691	5654-5665	NNS	denotes	experiments
T1693	5666-5673	VBG	denotes	seeking
T1694	5674-5676	TO	denotes	to
T1695	5677-5684	VB	denotes	explore
T1696	5685-5688	DT	denotes	the
T1698	5689-5697	JJ	denotes	possible
T1697	5698-5709	NN	denotes	involvement
T1699	5710-5712	IN	denotes	of
T1700	5713-5721	NN	denotes	dopamine
T1701	5722-5726	NNS	denotes	D2Rs
T1702	5727-5729	IN	denotes	in
T1703	5730-5741	JJ	denotes	associative
T1704	5742-5750	NN	denotes	learning
T1705	5751-5755	VBP	denotes	have
T1692	5756-5764	VBN	denotes	utilized
T1706	5765-5768	JJ	denotes	low
T1708	5769-5771	IN	denotes	to
T1709	5772-5780	JJ	denotes	moderate
T1707	5781-5786	NNS	denotes	doses
T1710	5787-5789	IN	denotes	of
T1711	5790-5795	NNS	denotes	drugs
T1712	5796-5797	-LRB-	denotes	[
T1714	5797-5798	CD	denotes	2
T1715	5798-5799	,	denotes	,
T1716	5799-5800	CD	denotes	5
T1717	5800-5801	,	denotes	,
T1713	5801-5802	CD	denotes	6
T1718	5802-5803	-RRB-	denotes	]
T1719	5804-5807	CC	denotes	and
T1720	5808-5812	NN	denotes	site
T1722	5812-5813	HYPH	denotes	-
T1721	5813-5821	JJ	denotes	specific
T1723	5822-5836	NN	denotes	administration
T1724	5837-5838	-LRB-	denotes	[
T1726	5838-5839	CD	denotes	7
T1727	5839-5840	,	denotes	,
T1725	5840-5841	CD	denotes	9
T1728	5841-5842	-RRB-	denotes	]
T1729	5843-5845	IN	denotes	in
T1730	5846-5851	NN	denotes	order
T1731	5852-5854	TO	denotes	to
T1732	5855-5860	VB	denotes	avoid
T1733	5861-5864	DT	denotes	the
T1735	5865-5876	VBG	denotes	confounding
T1734	5877-5883	NN	denotes	effect
T1736	5884-5888	WDT	denotes	that
T1738	5889-5898	NN	denotes	locomotor
T1739	5899-5909	NN	denotes	disruption
T1740	5910-5920	VBN	denotes	associated
T1741	5921-5925	IN	denotes	with
T1742	5926-5931	JJ	denotes	acute
T1744	5932-5935	NN	denotes	D2R
T1743	5936-5944	NN	denotes	blockade
T1745	5945-5948	MD	denotes	can
T1737	5949-5953	VB	denotes	have
T1746	5954-5956	IN	denotes	on
T1747	5957-5965	NN	denotes	learning
T1748	5966-5977	NN	denotes	performance
T1749	5978-5980	IN	denotes	in
T1750	5981-5988	NNS	denotes	rodents
T1751	5988-5989	.	denotes	.
T1752	5989-6170	sentence	denotes	Besides their lack of receptor subtype specificity, an acute exposure to commercially available D2 receptor antagonists fails to completely block signaling mediated solely by D2Rs.
T1753	5990-5997	IN	denotes	Besides
T1755	5998-6003	PRP$	denotes	their
T1756	6004-6008	NN	denotes	lack
T1757	6009-6011	IN	denotes	of
T1758	6012-6020	NN	denotes	receptor
T1759	6021-6028	NN	denotes	subtype
T1760	6029-6040	NN	denotes	specificity
T1761	6040-6042	,	denotes	,
T1762	6042-6044	DT	denotes	an
T1764	6045-6050	JJ	denotes	acute
T1763	6051-6059	NN	denotes	exposure
T1765	6060-6062	IN	denotes	to
T1766	6063-6075	RB	denotes	commercially
T1767	6076-6085	JJ	denotes	available
T1769	6086-6088	NN	denotes	D2
T1770	6089-6097	NN	denotes	receptor
T1768	6098-6109	NNS	denotes	antagonists
T1754	6110-6115	VBZ	denotes	fails
T1771	6116-6118	TO	denotes	to
T1773	6119-6129	RB	denotes	completely
T1772	6130-6135	VB	denotes	block
T1774	6136-6145	NN	denotes	signaling
T1775	6146-6154	VBN	denotes	mediated
T1776	6155-6161	RB	denotes	solely
T1777	6162-6164	IN	denotes	by
T1778	6165-6169	NNS	denotes	D2Rs
T1779	6169-6170	.	denotes	.
T1780	6170-6327	sentence	denotes	Moreover, acute dosing does not recapitulate the marked learning deficits produced in rodents [15,16] by chronic exposure to dopamine D2R antagonists [6,7].
T1781	6171-6179	RB	denotes	Moreover
T1783	6179-6181	,	denotes	,
T1784	6181-6186	JJ	denotes	acute
T1785	6187-6193	NN	denotes	dosing
T1786	6194-6198	VBZ	denotes	does
T1787	6199-6202	RB	denotes	not
T1782	6203-6215	VB	denotes	recapitulate
T1788	6216-6219	DT	denotes	the
T1790	6220-6226	JJ	denotes	marked
T1791	6227-6235	NN	denotes	learning
T1789	6236-6244	NNS	denotes	deficits
T1792	6245-6253	VBN	denotes	produced
T1793	6254-6256	IN	denotes	in
T1794	6257-6264	NNS	denotes	rodents
T1795	6265-6266	-LRB-	denotes	[
T1797	6266-6268	CD	denotes	15
T1798	6268-6269	,	denotes	,
T1796	6269-6271	CD	denotes	16
T1799	6271-6272	-RRB-	denotes	]
T1800	6273-6275	IN	denotes	by
T1801	6276-6283	JJ	denotes	chronic
T1802	6284-6292	NN	denotes	exposure
T1803	6293-6295	IN	denotes	to
T1804	6296-6304	NN	denotes	dopamine
T1805	6305-6308	NN	denotes	D2R
T1806	6309-6320	NNS	denotes	antagonists
T1807	6321-6322	-LRB-	denotes	[
T1809	6322-6323	CD	denotes	6
T1810	6323-6324	,	denotes	,
T1808	6324-6325	CD	denotes	7
T1811	6325-6326	-RRB-	denotes	]
T1812	6326-6327	.	denotes	.
T1813	6327-6424	sentence	denotes	The influence of dopamine D2R-mediated signaling on reversal learning is also poorly understood.
T1814	6328-6331	DT	denotes	The
T1815	6332-6341	NN	denotes	influence
T1817	6342-6344	IN	denotes	of
T1818	6345-6353	NN	denotes	dopamine
T1819	6354-6357	NN	denotes	D2R
T1821	6357-6358	HYPH	denotes	-
T1820	6358-6366	VBN	denotes	mediated
T1822	6367-6376	NN	denotes	signaling
T1823	6377-6379	IN	denotes	on
T1824	6380-6388	JJ	denotes	reversal
T1825	6389-6397	NN	denotes	learning
T1816	6398-6400	VBZ	denotes	is
T1826	6401-6405	RB	denotes	also
T1827	6406-6412	RB	denotes	poorly
T1828	6413-6423	VBN	denotes	understood
T1829	6423-6424	.	denotes	.
T1830	6424-6628	sentence	denotes	Reversal learning can be conceptualized as the ability to recognize an unexpected consequence to a previously established associative learning rule and then alter response strategies accordingly [17,18].
T1831	6425-6433	JJ	denotes	Reversal
T1832	6434-6442	NN	denotes	learning
T1834	6443-6446	MD	denotes	can
T1835	6447-6449	VB	denotes	be
T1833	6450-6464	VBN	denotes	conceptualized
T1836	6465-6467	IN	denotes	as
T1837	6468-6471	DT	denotes	the
T1838	6472-6479	NN	denotes	ability
T1839	6480-6482	TO	denotes	to
T1840	6483-6492	VB	denotes	recognize
T1841	6493-6495	DT	denotes	an
T1843	6496-6506	JJ	denotes	unexpected
T1842	6507-6518	NN	denotes	consequence
T1844	6519-6521	IN	denotes	to
T1845	6522-6523	DT	denotes	a
T1847	6524-6534	RB	denotes	previously
T1848	6535-6546	VBN	denotes	established
T1849	6547-6558	JJ	denotes	associative
T1850	6559-6567	NN	denotes	learning
T1846	6568-6572	NN	denotes	rule
T1851	6573-6576	CC	denotes	and
T1852	6577-6581	RB	denotes	then
T1853	6582-6587	VB	denotes	alter
T1854	6588-6596	NN	denotes	response
T1855	6597-6607	NNS	denotes	strategies
T1856	6608-6619	RB	denotes	accordingly
T1857	6620-6621	-LRB-	denotes	[
T1859	6621-6623	CD	denotes	17
T1860	6623-6624	,	denotes	,
T1858	6624-6626	CD	denotes	18
T1861	6626-6627	-RRB-	denotes	]
T1862	6627-6628	.	denotes	.
T1863	6628-6782	sentence	denotes	Reversal learning in rodents can serve as an index of learning adaptability and alertness that correlates with human attentional-shift paradigms [17,18].
T1864	6629-6637	JJ	denotes	Reversal
T1865	6638-6646	NN	denotes	learning
T1867	6647-6649	IN	denotes	in
T1868	6650-6657	NNS	denotes	rodents
T1869	6658-6661	MD	denotes	can
T1866	6662-6667	VB	denotes	serve
T1870	6668-6670	IN	denotes	as
T1871	6671-6673	DT	denotes	an
T1872	6674-6679	NN	denotes	index
T1873	6680-6682	IN	denotes	of
T1874	6683-6691	VBG	denotes	learning
T1875	6692-6704	NN	denotes	adaptability
T1876	6705-6708	CC	denotes	and
T1877	6709-6718	NN	denotes	alertness
T1878	6719-6723	WDT	denotes	that
T1879	6724-6734	VBZ	denotes	correlates
T1880	6735-6739	IN	denotes	with
T1881	6740-6745	JJ	denotes	human
T1883	6746-6757	JJ	denotes	attentional
T1885	6757-6758	HYPH	denotes	-
T1884	6758-6763	NN	denotes	shift
T1882	6764-6773	NNS	denotes	paradigms
T1886	6774-6775	-LRB-	denotes	[
T1888	6775-6777	CD	denotes	17
T1889	6777-6778	,	denotes	,
T1887	6778-6780	CD	denotes	18
T1890	6780-6781	-RRB-	denotes	]
T1891	6781-6782	.	denotes	.
T1892	6782-6954	sentence	denotes	Additionally, a previous report demonstrated that excitotoxic lesions of terminal field targets of mesocortical dopamine have been shown to disrupt reversal learning [19].
T1893	6783-6795	RB	denotes	Additionally
T1895	6795-6797	,	denotes	,
T1896	6797-6798	DT	denotes	a
T1898	6799-6807	JJ	denotes	previous
T1897	6808-6814	NN	denotes	report
T1894	6815-6827	VBD	denotes	demonstrated
T1899	6828-6832	IN	denotes	that
T1901	6833-6844	JJ	denotes	excitotoxic
T1902	6845-6852	NNS	denotes	lesions
T1903	6853-6855	IN	denotes	of
T1904	6856-6864	JJ	denotes	terminal
T1905	6865-6870	NN	denotes	field
T1906	6871-6878	NNS	denotes	targets
T1907	6879-6881	IN	denotes	of
T1908	6882-6894	JJ	denotes	mesocortical
T1909	6895-6903	NN	denotes	dopamine
T1910	6904-6908	VBP	denotes	have
T1911	6909-6913	VBN	denotes	been
T1900	6914-6919	VBN	denotes	shown
T1912	6920-6922	TO	denotes	to
T1913	6923-6930	VB	denotes	disrupt
T1914	6931-6939	NN	denotes	reversal
T1915	6940-6948	NN	denotes	learning
T1916	6949-6950	-LRB-	denotes	[
T1917	6950-6952	CD	denotes	19
T1918	6952-6953	-RRB-	denotes	]
T1919	6953-6954	.	denotes	.
T1920	6954-7162	sentence	denotes	Administration of the D2R/D3R antagonist, sulpiride, impairs spatial reversal leaning in mice [20] and has also been shown to impair attention and the cognitive performances of healthy human volunteers [21].
T1921	6955-6969	NN	denotes	Administration
T1923	6970-6972	IN	denotes	of
T1924	6973-6976	DT	denotes	the
T1926	6977-6980	NN	denotes	D2R
T1928	6980-6981	HYPH	denotes	/
T1927	6981-6984	NN	denotes	D3R
T1925	6985-6995	NN	denotes	antagonist
T1929	6995-6997	,	denotes	,
T1930	6997-7006	NN	denotes	sulpiride
T1931	7006-7008	,	denotes	,
T1922	7008-7015	VBZ	denotes	impairs
T1932	7016-7023	JJ	denotes	spatial
T1934	7024-7032	NN	denotes	reversal
T1933	7033-7040	NN	denotes	leaning
T1935	7041-7043	IN	denotes	in
T1936	7044-7048	NNS	denotes	mice
T1937	7049-7050	-LRB-	denotes	[
T1938	7050-7052	CD	denotes	20
T1939	7052-7053	-RRB-	denotes	]
T1940	7054-7057	CC	denotes	and
T1941	7058-7061	VBZ	denotes	has
T1943	7062-7066	RB	denotes	also
T1944	7067-7071	VBN	denotes	been
T1942	7072-7077	VBN	denotes	shown
T1945	7078-7080	TO	denotes	to
T1946	7081-7087	VB	denotes	impair
T1947	7088-7097	NN	denotes	attention
T1948	7098-7101	CC	denotes	and
T1949	7102-7105	DT	denotes	the
T1951	7106-7115	JJ	denotes	cognitive
T1950	7116-7128	NNS	denotes	performances
T1952	7129-7131	IN	denotes	of
T1953	7132-7139	JJ	denotes	healthy
T1955	7140-7145	JJ	denotes	human
T1954	7146-7156	NNS	denotes	volunteers
T1956	7157-7158	-LRB-	denotes	[
T1957	7158-7160	CD	denotes	21
T1958	7160-7161	-RRB-	denotes	]
T1959	7161-7162	.	denotes	.
T1960	7162-7295	sentence	denotes	Moreover an inverse relationship between lower dopamine D2R levels and compulsive behavior in human subjects has been reported [22].
T1961	7163-7171	RB	denotes	Moreover
T1963	7172-7174	DT	denotes	an
T1965	7175-7182	JJ	denotes	inverse
T1964	7183-7195	NN	denotes	relationship
T1966	7196-7203	IN	denotes	between
T1967	7204-7209	JJR	denotes	lower
T1969	7210-7218	NN	denotes	dopamine
T1970	7219-7222	NN	denotes	D2R
T1968	7223-7229	NNS	denotes	levels
T1971	7230-7233	CC	denotes	and
T1972	7234-7244	JJ	denotes	compulsive
T1973	7245-7253	NN	denotes	behavior
T1974	7254-7256	IN	denotes	in
T1975	7257-7262	JJ	denotes	human
T1976	7263-7271	NNS	denotes	subjects
T1977	7272-7275	VBZ	denotes	has
T1978	7276-7280	VBN	denotes	been
T1962	7281-7289	VBN	denotes	reported
T1979	7290-7291	-LRB-	denotes	[
T1980	7291-7293	CD	denotes	22
T1981	7293-7294	-RRB-	denotes	]
T1982	7294-7295	.	denotes	.
T1983	7295-7443	sentence	denotes	Taken together these findings suggest that D2R-mediated signaling could play a critical role in reversal learning but are insufficient to prove it.
T1984	7296-7301	VBN	denotes	Taken
T1986	7302-7310	RB	denotes	together
T1987	7311-7316	DT	denotes	these
T1988	7317-7325	NNS	denotes	findings
T1985	7326-7333	VBP	denotes	suggest
T1989	7334-7338	IN	denotes	that
T1991	7339-7342	NN	denotes	D2R
T1993	7342-7343	HYPH	denotes	-
T1992	7343-7351	VBN	denotes	mediated
T1994	7352-7361	NN	denotes	signaling
T1995	7362-7367	MD	denotes	could
T1990	7368-7372	VB	denotes	play
T1996	7373-7374	DT	denotes	a
T1998	7375-7383	JJ	denotes	critical
T1997	7384-7388	NN	denotes	role
T1999	7389-7391	IN	denotes	in
T2000	7392-7400	JJ	denotes	reversal
T2001	7401-7409	NN	denotes	learning
T2002	7410-7413	CC	denotes	but
T2003	7414-7417	VBP	denotes	are
T2004	7418-7430	JJ	denotes	insufficient
T2005	7431-7433	TO	denotes	to
T2006	7434-7439	VB	denotes	prove
T2007	7440-7442	PRP	denotes	it
T2008	7442-7443	.	denotes	.
T2009	7443-7870	sentence	denotes	In an effort to establish the contribution of dopamine D2 receptor-mediated signaling to associative and non-spatial reversal learning in adult mice, we compared mice [23] that had developed in the complete absence of all functional dopamine D2 receptors (D2R-/-) to wild-type littermates (D2R+/+) in a go/no-go operant learning procedure that measures primary reinforcement, sensory processing, and reversal learning [17-19].
T2010	7444-7446	IN	denotes	In
T2012	7447-7449	DT	denotes	an
T2013	7450-7456	NN	denotes	effort
T2014	7457-7459	TO	denotes	to
T2015	7460-7469	VB	denotes	establish
T2016	7470-7473	DT	denotes	the
T2017	7474-7486	NN	denotes	contribution
T2018	7487-7489	IN	denotes	of
T2019	7490-7498	NN	denotes	dopamine
T2021	7499-7501	NN	denotes	D2
T2020	7502-7510	NN	denotes	receptor
T2023	7510-7511	HYPH	denotes	-
T2022	7511-7519	VBN	denotes	mediated
T2024	7520-7529	NN	denotes	signaling
T2025	7530-7532	IN	denotes	to
T2026	7533-7544	JJ	denotes	associative
T2028	7545-7548	CC	denotes	and
T2029	7549-7560	JJ	denotes	non-spatial
T2030	7561-7569	NN	denotes	reversal
T2027	7570-7578	NN	denotes	learning
T2031	7579-7581	IN	denotes	in
T2032	7582-7587	JJ	denotes	adult
T2033	7588-7592	NNS	denotes	mice
T2034	7592-7594	,	denotes	,
T2035	7594-7596	PRP	denotes	we
T2011	7597-7605	VBD	denotes	compared
T2036	7606-7610	NNS	denotes	mice
T2037	7611-7612	-LRB-	denotes	[
T2038	7612-7614	CD	denotes	23
T2039	7614-7615	-RRB-	denotes	]
T2040	7616-7620	WDT	denotes	that
T2042	7621-7624	VBD	denotes	had
T2041	7625-7634	VBN	denotes	developed
T2043	7635-7637	IN	denotes	in
T2044	7638-7641	DT	denotes	the
T2046	7642-7650	JJ	denotes	complete
T2045	7651-7658	NN	denotes	absence
T2047	7659-7661	IN	denotes	of
T2048	7662-7665	DT	denotes	all
T2050	7666-7676	JJ	denotes	functional
T2051	7677-7685	NN	denotes	dopamine
T2052	7686-7688	NN	denotes	D2
T2049	7689-7698	NNS	denotes	receptors
T2053	7699-7700	-LRB-	denotes	(
T2054	7700-7703	NN	denotes	D2R
T2055	7703-7704	SYM	denotes	-
T2056	7704-7705	HYPH	denotes	/
T2057	7705-7706	SYM	denotes	-
T2058	7706-7707	-RRB-	denotes	)
T2059	7708-7710	IN	denotes	to
T2060	7711-7715	JJ	denotes	wild
T2062	7715-7716	HYPH	denotes	-
T2061	7716-7720	NN	denotes	type
T2063	7721-7732	NNS	denotes	littermates
T2064	7733-7734	-LRB-	denotes	(
T2065	7734-7737	NN	denotes	D2R
T2066	7737-7738	SYM	denotes	+
T2067	7738-7739	HYPH	denotes	/
T2068	7739-7740	SYM	denotes	+
T2069	7740-7741	-RRB-	denotes	)
T2070	7742-7744	IN	denotes	in
T2071	7745-7746	DT	denotes	a
T2073	7747-7749	NN	denotes	go
T2074	7749-7750	HYPH	denotes	/
T2075	7750-7752	DT	denotes	no
T2077	7752-7753	HYPH	denotes	-
T2076	7753-7755	NN	denotes	go
T2078	7756-7763	NN	denotes	operant
T2079	7764-7772	VBG	denotes	learning
T2072	7773-7782	NN	denotes	procedure
T2080	7783-7787	WDT	denotes	that
T2081	7788-7796	VBZ	denotes	measures
T2082	7797-7804	JJ	denotes	primary
T2083	7805-7818	NN	denotes	reinforcement
T2084	7818-7820	,	denotes	,
T2085	7820-7827	JJ	denotes	sensory
T2086	7828-7838	NN	denotes	processing
T2087	7838-7840	,	denotes	,
T2088	7840-7843	CC	denotes	and
T2089	7844-7852	NN	denotes	reversal
T2090	7853-7861	NN	denotes	learning
T2091	7862-7863	-LRB-	denotes	[
T2092	7863-7865	CD	denotes	17
T2093	7865-7866	SYM	denotes	-
T2094	7866-7868	CD	denotes	19
T2095	7868-7869	-RRB-	denotes	]
T2096	7869-7870	.	denotes	.
T2097	7870-8145	sentence	denotes	Here we report that dopamine D2R-mediated signaling must be intact if a mouse is to efficiently learn to associate a food reinforcer with a specific odor and then adaptively disengage inappropriate behavioral strategies following the reversal of reinforcement contingencies.
T2098	7871-7875	RB	denotes	Here
T2100	7876-7878	PRP	denotes	we
T2099	7879-7885	VBP	denotes	report
T2101	7886-7890	IN	denotes	that
T2103	7891-7899	NN	denotes	dopamine
T2104	7900-7903	NN	denotes	D2R
T2106	7903-7904	HYPH	denotes	-
T2105	7904-7912	VBN	denotes	mediated
T2107	7913-7922	NN	denotes	signaling
T2108	7923-7927	MD	denotes	must
T2102	7928-7930	VB	denotes	be
T2109	7931-7937	JJ	denotes	intact
T2110	7938-7940	IN	denotes	if
T2112	7941-7942	DT	denotes	a
T2113	7943-7948	NN	denotes	mouse
T2111	7949-7951	VBZ	denotes	is
T2114	7952-7954	TO	denotes	to
T2116	7955-7966	RB	denotes	efficiently
T2115	7967-7972	VB	denotes	learn
T2117	7973-7975	TO	denotes	to
T2118	7976-7985	VB	denotes	associate
T2119	7986-7987	DT	denotes	a
T2121	7988-7992	NN	denotes	food
T2120	7993-8003	NN	denotes	reinforcer
T2122	8004-8008	IN	denotes	with
T2123	8009-8010	DT	denotes	a
T2125	8011-8019	JJ	denotes	specific
T2124	8020-8024	NN	denotes	odor
T2126	8025-8028	CC	denotes	and
T2127	8029-8033	RB	denotes	then
T2129	8034-8044	RB	denotes	adaptively
T2128	8045-8054	VB	denotes	disengage
T2130	8055-8068	JJ	denotes	inappropriate
T2132	8069-8079	JJ	denotes	behavioral
T2131	8080-8090	NNS	denotes	strategies
T2133	8091-8100	VBG	denotes	following
T2134	8101-8104	DT	denotes	the
T2135	8105-8113	NN	denotes	reversal
T2136	8114-8116	IN	denotes	of
T2137	8117-8130	NN	denotes	reinforcement
T2138	8131-8144	NNS	denotes	contingencies
T2139	8144-8145	.	denotes	.
T2198	8156-8160	CC	denotes	Both
T2200	8161-8165	JJ	denotes	wild
T2201	8165-8166	HYPH	denotes	-
T2199	8166-8170	NN	denotes	type
T2203	8171-8174	CC	denotes	and
T2204	8175-8178	NN	denotes	D2R
T2205	8179-8188	JJ	denotes	deficient
T2202	8189-8193	NNS	denotes	mice
T2206	8194-8199	VBP	denotes	learn
T2207	8200-8207	NN	denotes	operant
T2208	8208-8217	NNS	denotes	behaviors
T2209	8218-8225	RB	denotes	equally
T2210	8226-8230	RB	denotes	well
T2211	8230-8356	sentence	denotes	Mildly food-deprived D2R+/+ and D2R-/- mice readily learned to locate and consume food pellets during both training sessions.
T2212	8231-8237	RB	denotes	Mildly
T2214	8238-8242	NN	denotes	food
T2215	8242-8243	HYPH	denotes	-
T2213	8243-8251	VBN	denotes	deprived
T2217	8252-8255	NN	denotes	D2R
T2218	8255-8256	SYM	denotes	+
T2219	8256-8257	HYPH	denotes	/
T2220	8257-8258	SYM	denotes	+
T2221	8259-8262	CC	denotes	and
T2222	8263-8266	NN	denotes	D2R
T2223	8266-8267	SYM	denotes	-
T2224	8267-8268	HYPH	denotes	/
T2225	8268-8269	SYM	denotes	-
T2216	8270-8274	NNS	denotes	mice
T2227	8275-8282	RB	denotes	readily
T2226	8283-8290	VBD	denotes	learned
T2228	8291-8293	TO	denotes	to
T2229	8294-8300	VB	denotes	locate
T2230	8301-8304	CC	denotes	and
T2231	8305-8312	VB	denotes	consume
T2232	8313-8317	NN	denotes	food
T2233	8318-8325	NNS	denotes	pellets
T2234	8326-8332	IN	denotes	during
T2235	8333-8337	DT	denotes	both
T2237	8338-8346	NN	denotes	training
T2236	8347-8355	NNS	denotes	sessions
T2238	8355-8356	.	denotes	.
T2239	8356-8463	sentence	denotes	Figure 1 depicts the latency for both genotypes to ambulate to a dish to retrieve an unhidden food pellet.
T2240	8357-8363	NN	denotes	Figure
T2242	8364-8365	CD	denotes	1
T2241	8366-8373	VBZ	denotes	depicts
T2243	8374-8377	DT	denotes	the
T2244	8378-8385	NN	denotes	latency
T2245	8386-8389	IN	denotes	for
T2247	8390-8394	DT	denotes	both
T2248	8395-8404	NNS	denotes	genotypes
T2249	8405-8407	TO	denotes	to
T2246	8408-8416	VB	denotes	ambulate
T2250	8417-8419	IN	denotes	to
T2251	8420-8421	DT	denotes	a
T2252	8422-8426	NN	denotes	dish
T2253	8427-8429	TO	denotes	to
T2254	8430-8438	VB	denotes	retrieve
T2255	8439-8441	DT	denotes	an
T2257	8442-8450	JJ	denotes	unhidden
T2258	8451-8455	NN	denotes	food
T2256	8456-8462	NN	denotes	pellet
T2259	8462-8463	.	denotes	.
T2260	8463-8701	sentence	denotes	There were no differences between genotypes to retrieve the reinforcers (F1,59 = 0.2, p > 0.65), and both groups significantly decreased the amount of time necessary to perform this task along successive trials (F4,59 = 5.74, p < 0.001).
T2261	8464-8469	EX	denotes	There
T2262	8470-8474	VBD	denotes	were
T2263	8475-8477	DT	denotes	no
T2264	8478-8489	NNS	denotes	differences
T2265	8490-8497	IN	denotes	between
T2266	8498-8507	NNS	denotes	genotypes
T2267	8508-8510	TO	denotes	to
T2268	8511-8519	VB	denotes	retrieve
T2269	8520-8523	DT	denotes	the
T2270	8524-8535	NNS	denotes	reinforcers
T2271	8536-8537	-LRB-	denotes	(
T2273	8537-8539	NN	denotes	F1
T2275	8539-8540	,	denotes	,
T2276	8540-8542	CD	denotes	59
T2277	8543-8544	SYM	denotes	=
T2274	8545-8548	CD	denotes	0.2
T2278	8548-8550	,	denotes	,
T2279	8550-8551	NN	denotes	p
T2280	8552-8553	SYM	denotes	>
T2272	8554-8558	CD	denotes	0.65
T2281	8558-8559	-RRB-	denotes	)
T2282	8559-8561	,	denotes	,
T2283	8561-8564	CC	denotes	and
T2284	8565-8569	DT	denotes	both
T2285	8570-8576	NNS	denotes	groups
T2287	8577-8590	RB	denotes	significantly
T2286	8591-8600	VBD	denotes	decreased
T2288	8601-8604	DT	denotes	the
T2289	8605-8611	NN	denotes	amount
T2290	8612-8614	IN	denotes	of
T2291	8615-8619	NN	denotes	time
T2292	8620-8629	JJ	denotes	necessary
T2293	8630-8632	TO	denotes	to
T2294	8633-8640	VB	denotes	perform
T2295	8641-8645	DT	denotes	this
T2296	8646-8650	NN	denotes	task
T2297	8651-8656	IN	denotes	along
T2298	8657-8667	JJ	denotes	successive
T2299	8668-8674	NNS	denotes	trials
T2300	8675-8676	-LRB-	denotes	(
T2302	8676-8678	NN	denotes	F4
T2304	8678-8679	,	denotes	,
T2305	8679-8681	CD	denotes	59
T2306	8682-8683	SYM	denotes	=
T2303	8684-8688	CD	denotes	5.74
T2307	8688-8690	,	denotes	,
T2308	8690-8691	NN	denotes	p
T2309	8692-8693	SYM	denotes	<
T2301	8694-8699	CD	denotes	0.001
T2310	8699-8700	-RRB-	denotes	)
T2311	8700-8701	.	denotes	.
T2312	8701-8809	sentence	denotes	Figure 2 depicts the latency to dig for the food pellet buried in a single dish filled with unscented sand.
T2313	8702-8708	NN	denotes	Figure
T2315	8709-8710	CD	denotes	2
T2314	8711-8718	VBZ	denotes	depicts
T2316	8719-8722	DT	denotes	the
T2317	8723-8730	NN	denotes	latency
T2318	8731-8733	TO	denotes	to
T2319	8734-8737	VB	denotes	dig
T2320	8738-8741	IN	denotes	for
T2321	8742-8745	DT	denotes	the
T2323	8746-8750	NN	denotes	food
T2322	8751-8757	NN	denotes	pellet
T2324	8758-8764	VBN	denotes	buried
T2325	8765-8767	IN	denotes	in
T2326	8768-8769	DT	denotes	a
T2328	8770-8776	JJ	denotes	single
T2327	8777-8781	NN	denotes	dish
T2329	8782-8788	VBN	denotes	filled
T2330	8789-8793	IN	denotes	with
T2331	8794-8803	JJ	denotes	unscented
T2332	8804-8808	NN	denotes	sand
T2333	8808-8809	.	denotes	.
T2334	8809-8941	sentence	denotes	No genotype differences were found in the ability to dig through unscented sand for a hidden food pellet (F1,128 = 1.26, p > 0.27).
T2335	8810-8812	DT	denotes	No
T2337	8813-8821	NN	denotes	genotype
T2336	8822-8833	NNS	denotes	differences
T2339	8834-8838	VBD	denotes	were
T2338	8839-8844	VBN	denotes	found
T2340	8845-8847	IN	denotes	in
T2341	8848-8851	DT	denotes	the
T2342	8852-8859	NN	denotes	ability
T2343	8860-8862	TO	denotes	to
T2344	8863-8866	VB	denotes	dig
T2345	8867-8874	IN	denotes	through
T2346	8875-8884	JJ	denotes	unscented
T2347	8885-8889	NN	denotes	sand
T2348	8890-8893	IN	denotes	for
T2349	8894-8895	DT	denotes	a
T2351	8896-8902	JJ	denotes	hidden
T2352	8903-8907	NN	denotes	food
T2350	8908-8914	NN	denotes	pellet
T2353	8915-8916	-LRB-	denotes	(
T2355	8916-8918	NN	denotes	F1
T2357	8918-8919	,	denotes	,
T2358	8919-8922	CD	denotes	128
T2359	8923-8924	SYM	denotes	=
T2356	8925-8929	CD	denotes	1.26
T2360	8929-8931	,	denotes	,
T2361	8931-8932	NN	denotes	p
T2362	8933-8934	SYM	denotes	>
T2354	8935-8939	CD	denotes	0.27
T2363	8939-8940	-RRB-	denotes	)
T2364	8940-8941	.	denotes	.
T2413	8943-8947	JJ	denotes	Wild
T2415	8947-8948	HYPH	denotes	-
T2414	8948-8952	NN	denotes	type
T2416	8953-8957	NNS	denotes	mice
T2417	8958-8968	VBP	denotes	outperform
T2418	8969-8972	NN	denotes	D2R
T2420	8972-8973	SYM	denotes	-
T2421	8973-8974	HYPH	denotes	/
T2422	8974-8975	SYM	denotes	-
T2419	8976-8980	NNS	denotes	mice
T2423	8981-8983	IN	denotes	in
T2424	8984-8986	DT	denotes	an
T2426	8987-8991	NN	denotes	odor
T2428	8991-8992	HYPH	denotes	-
T2427	8992-8998	VBN	denotes	driven
T2429	8998-9000	,	denotes	,
T2430	9000-9008	NN	denotes	stimulus
T2432	9008-9009	HYPH	denotes	-
T2431	9009-9023	NN	denotes	discrimination
T2433	9023-9025	,	denotes	,
T2434	9025-9032	NN	denotes	operant
T2425	9033-9037	NN	denotes	task
T2435	9037-9342	sentence	denotes	To master the odor-driven stimulus discrimination task, D2R-/- mice required significantly more trials (Fig. 3A: t(14) = 2.20; p < 0.05) and committed more errors (Fig. 3B: t(14) = 2.92; p < 0.05) than D2R+/+ mice to learn to associate a specific odor with the presence or absence of the food reinforcer.
T2436	9038-9040	TO	denotes	To
T2437	9041-9047	VB	denotes	master
T2439	9048-9051	DT	denotes	the
T2441	9052-9056	NN	denotes	odor
T2443	9056-9057	HYPH	denotes	-
T2442	9057-9063	VBN	denotes	driven
T2444	9064-9072	NN	denotes	stimulus
T2445	9073-9087	NN	denotes	discrimination
T2440	9088-9092	NN	denotes	task
T2446	9092-9094	,	denotes	,
T2447	9094-9097	NN	denotes	D2R
T2449	9097-9098	SYM	denotes	-
T2450	9098-9099	HYPH	denotes	/
T2451	9099-9100	SYM	denotes	-
T2448	9101-9105	NNS	denotes	mice
T2438	9106-9114	VBD	denotes	required
T2452	9115-9128	RB	denotes	significantly
T2453	9129-9133	JJR	denotes	more
T2454	9134-9140	NNS	denotes	trials
T2455	9141-9142	-LRB-	denotes	(
T2456	9142-9146	NN	denotes	Fig.
T2457	9147-9149	CD	denotes	3A
T2458	9149-9151	:	denotes	:
T2459	9151-9152	NN	denotes	t
T2461	9152-9153	-LRB-	denotes	(
T2462	9153-9155	CD	denotes	14
T2463	9155-9156	-RRB-	denotes	)
T2464	9157-9158	SYM	denotes	=
T2460	9159-9163	CD	denotes	2.20
T2465	9163-9164	:	denotes	;
T2466	9165-9166	NN	denotes	p
T2468	9167-9168	SYM	denotes	<
T2467	9169-9173	CD	denotes	0.05
T2469	9173-9174	-RRB-	denotes	)
T2470	9175-9178	CC	denotes	and
T2471	9179-9188	VBD	denotes	committed
T2472	9189-9193	JJR	denotes	more
T2473	9194-9200	NNS	denotes	errors
T2474	9201-9202	-LRB-	denotes	(
T2475	9202-9206	NN	denotes	Fig.
T2476	9207-9209	CD	denotes	3B
T2477	9209-9211	:	denotes	:
T2478	9211-9212	NN	denotes	t
T2480	9212-9213	-LRB-	denotes	(
T2481	9213-9215	CD	denotes	14
T2482	9215-9216	-RRB-	denotes	)
T2483	9217-9218	SYM	denotes	=
T2479	9219-9223	CD	denotes	2.92
T2484	9223-9224	:	denotes	;
T2485	9225-9226	NN	denotes	p
T2487	9227-9228	SYM	denotes	<
T2486	9229-9233	CD	denotes	0.05
T2488	9233-9234	-RRB-	denotes	)
T2489	9235-9239	IN	denotes	than
T2490	9240-9243	NN	denotes	D2R
T2492	9243-9244	SYM	denotes	+
T2493	9244-9245	HYPH	denotes	/
T2494	9245-9246	SYM	denotes	+
T2491	9247-9251	NNS	denotes	mice
T2495	9252-9254	TO	denotes	to
T2496	9255-9260	VB	denotes	learn
T2497	9261-9263	TO	denotes	to
T2498	9264-9273	VB	denotes	associate
T2499	9274-9275	DT	denotes	a
T2501	9276-9284	JJ	denotes	specific
T2500	9285-9289	NN	denotes	odor
T2502	9290-9294	IN	denotes	with
T2503	9295-9298	DT	denotes	the
T2504	9299-9307	NN	denotes	presence
T2505	9308-9310	CC	denotes	or
T2506	9311-9318	NN	denotes	absence
T2507	9319-9321	IN	denotes	of
T2508	9322-9325	DT	denotes	the
T2510	9326-9330	NN	denotes	food
T2509	9331-9341	NN	denotes	reinforcer
T2511	9341-9342	.	denotes	.
T2512	9342-9490	sentence	denotes	However, both genotypes did learn the task and eventually maintained accurate discrimination for a minimum of 8 correct responses out of 10 trials.
T2513	9343-9350	RB	denotes	However
T2515	9350-9352	,	denotes	,
T2516	9352-9356	DT	denotes	both
T2517	9357-9366	NNS	denotes	genotypes
T2518	9367-9370	VBD	denotes	did
T2514	9371-9376	VB	denotes	learn
T2519	9377-9380	DT	denotes	the
T2520	9381-9385	NN	denotes	task
T2521	9386-9389	CC	denotes	and
T2522	9390-9400	RB	denotes	eventually
T2523	9401-9411	VBD	denotes	maintained
T2524	9412-9420	JJ	denotes	accurate
T2525	9421-9435	NN	denotes	discrimination
T2526	9436-9439	IN	denotes	for
T2527	9440-9441	DT	denotes	a
T2528	9442-9449	NN	denotes	minimum
T2529	9450-9452	IN	denotes	of
T2530	9453-9454	CD	denotes	8
T2532	9455-9462	JJ	denotes	correct
T2531	9463-9472	NNS	denotes	responses
T2533	9473-9476	IN	denotes	out
T2534	9477-9479	IN	denotes	of
T2535	9480-9482	CD	denotes	10
T2536	9483-9489	NNS	denotes	trials
T2537	9489-9490	.	denotes	.
T2709	9492-9496	NNS	denotes	Mice
T2711	9497-9504	VBG	denotes	lacking
T2712	9505-9513	NN	denotes	dopamine
T2713	9514-9516	NN	denotes	D2
T2714	9517-9526	NNS	denotes	receptors
T2710	9527-9533	VBP	denotes	engage
T2715	9534-9536	IN	denotes	in
T2716	9537-9549	JJ	denotes	unreinforced
T2717	9550-9558	NN	denotes	behavior
T2718	9559-9561	IN	denotes	in
T2719	9562-9563	DT	denotes	a
T2721	9564-9577	JJ	denotes	perseverative
T2720	9578-9584	NN	denotes	manner
T2722	9585-9594	VBG	denotes	following
T2723	9595-9603	NN	denotes	reversal
T2724	9604-9606	IN	denotes	of
T2725	9607-9620	NN	denotes	reinforcement
T2726	9621-9634	NNS	denotes	contingencies
T2727	9634-9878	sentence	denotes	D2R-/- mice repeatedly failed to inhibit previously established learning contingencies during reversal trials (Fig. 4A: t(14) = 3.54; p < 0.01) and committed significantly more reversal errors than D2R+/+ mice (Fig. 4B: t(14)= 3.18; p < 0.01).
T2728	9635-9638	NN	denotes	D2R
T2730	9638-9639	SYM	denotes	-
T2731	9639-9640	HYPH	denotes	/
T2732	9640-9641	SYM	denotes	-
T2729	9642-9646	NNS	denotes	mice
T2734	9647-9657	RB	denotes	repeatedly
T2733	9658-9664	VBD	denotes	failed
T2735	9665-9667	TO	denotes	to
T2736	9668-9675	VB	denotes	inhibit
T2737	9676-9686	RB	denotes	previously
T2738	9687-9698	VBN	denotes	established
T2740	9699-9707	VBG	denotes	learning
T2739	9708-9721	NNS	denotes	contingencies
T2741	9722-9728	IN	denotes	during
T2742	9729-9737	JJ	denotes	reversal
T2743	9738-9744	NNS	denotes	trials
T2744	9745-9746	-LRB-	denotes	(
T2745	9746-9750	NN	denotes	Fig.
T2746	9751-9753	CD	denotes	4A
T2747	9753-9755	:	denotes	:
T2748	9755-9756	NN	denotes	t
T2750	9756-9757	-LRB-	denotes	(
T2751	9757-9759	CD	denotes	14
T2752	9759-9760	-RRB-	denotes	)
T2753	9761-9762	SYM	denotes	=
T2749	9763-9767	CD	denotes	3.54
T2754	9767-9768	:	denotes	;
T2755	9769-9770	NN	denotes	p
T2757	9771-9772	SYM	denotes	<
T2756	9773-9777	CD	denotes	0.01
T2758	9777-9778	-RRB-	denotes	)
T2759	9779-9782	CC	denotes	and
T2760	9783-9792	VBD	denotes	committed
T2761	9793-9806	RB	denotes	significantly
T2762	9807-9811	JJR	denotes	more
T2764	9812-9820	NN	denotes	reversal
T2763	9821-9827	NNS	denotes	errors
T2765	9828-9832	IN	denotes	than
T2766	9833-9836	NN	denotes	D2R
T2768	9836-9837	SYM	denotes	+
T2769	9837-9838	HYPH	denotes	/
T2770	9838-9839	SYM	denotes	+
T2767	9840-9844	NNS	denotes	mice
T2771	9845-9846	-LRB-	denotes	(
T2772	9846-9850	NN	denotes	Fig.
T2773	9851-9853	CD	denotes	4B
T2774	9853-9855	:	denotes	:
T2775	9855-9856	NN	denotes	t
T2777	9856-9857	-LRB-	denotes	(
T2778	9857-9859	CD	denotes	14
T2779	9859-9860	-RRB-	denotes	)
T2780	9860-9861	SYM	denotes	=
T2776	9862-9866	CD	denotes	3.18
T2781	9866-9867	:	denotes	;
T2782	9868-9869	NN	denotes	p
T2784	9870-9871	SYM	denotes	<
T2783	9872-9876	CD	denotes	0.01
T2785	9876-9877	-RRB-	denotes	)
T2786	9877-9878	.	denotes	.
T2787	9878-10465	sentence	denotes	Categorical division of reversal errors (Ferry et al., 2000) – digging in the dish that did not contain the food pellet (S-) (error of commission; Fig. 5A) versus failing to respond within 3-min of presentation (error of omission; Fig. 5B) revealed that both genotypes chiefly committed errors of commission versus errors of omission (D2R-/- mice, U = 0.00; p < 0.01; D2R+/+ mice U = 9.00, p < 0.05), D2R-/- mice committed more commission errors than D2R+/+ mice (U = 5.00, p < 0.05), and there were no differences between D2R-/- and D2R+/+ mice in omission errors (U = 27.5, p = 0.65).
T2788	9879-9890	JJ	denotes	Categorical
T2789	9891-9899	NN	denotes	division
T2791	9900-9902	IN	denotes	of
T2792	9903-9911	NN	denotes	reversal
T2793	9912-9918	NNS	denotes	errors
T2794	9919-9920	-LRB-	denotes	(
T2795	9920-9925	NNP	denotes	Ferry
T2796	9926-9928	FW	denotes	et
T2797	9929-9932	FW	denotes	al.
T2798	9932-9934	,	denotes	,
T2799	9934-9938	CD	denotes	2000
T2800	9938-9939	-RRB-	denotes	)
T2801	9940-9941	:	denotes	–
T2802	9942-9949	VBG	denotes	digging
T2803	9950-9952	IN	denotes	in
T2804	9953-9956	DT	denotes	the
T2805	9957-9961	NN	denotes	dish
T2806	9962-9966	WDT	denotes	that
T2808	9967-9970	VBD	denotes	did
T2809	9971-9974	RB	denotes	not
T2807	9975-9982	VB	denotes	contain
T2810	9983-9986	DT	denotes	the
T2812	9987-9991	NN	denotes	food
T2811	9992-9998	NN	denotes	pellet
T2813	9999-10000	-LRB-	denotes	(
T2814	10000-10001	NN	denotes	S
T2815	10001-10002	SYM	denotes	-
T2816	10002-10003	-RRB-	denotes	)
T2817	10004-10005	-LRB-	denotes	(
T2819	10005-10010	NN	denotes	error
T2820	10011-10013	IN	denotes	of
T2821	10014-10024	NN	denotes	commission
T2822	10024-10025	:	denotes	;
T2818	10026-10030	NN	denotes	Fig.
T2823	10031-10033	CD	denotes	5A
T2824	10033-10034	-RRB-	denotes	)
T2825	10035-10041	CC	denotes	versus
T2826	10042-10049	VBG	denotes	failing
T2827	10050-10052	TO	denotes	to
T2828	10053-10060	VB	denotes	respond
T2829	10061-10067	IN	denotes	within
T2830	10068-10069	CD	denotes	3
T2832	10069-10070	HYPH	denotes	-
T2831	10070-10073	NN	denotes	min
T2833	10074-10076	IN	denotes	of
T2834	10077-10089	NN	denotes	presentation
T2835	10090-10091	-LRB-	denotes	(
T2837	10091-10096	NN	denotes	error
T2838	10097-10099	IN	denotes	of
T2839	10100-10108	NN	denotes	omission
T2840	10108-10109	:	denotes	;
T2836	10110-10114	NN	denotes	Fig.
T2841	10115-10117	CD	denotes	5B
T2842	10117-10118	-RRB-	denotes	)
T2790	10119-10127	VBD	denotes	revealed
T2843	10128-10132	IN	denotes	that
T2845	10133-10137	DT	denotes	both
T2846	10138-10147	NNS	denotes	genotypes
T2847	10148-10155	RB	denotes	chiefly
T2844	10156-10165	VBD	denotes	committed
T2848	10166-10172	NNS	denotes	errors
T2849	10173-10175	IN	denotes	of
T2850	10176-10186	NN	denotes	commission
T2851	10187-10193	CC	denotes	versus
T2852	10194-10200	NNS	denotes	errors
T2853	10201-10203	IN	denotes	of
T2854	10204-10212	NN	denotes	omission
T2855	10213-10214	-LRB-	denotes	(
T2857	10214-10217	NN	denotes	D2R
T2859	10217-10218	SYM	denotes	-
T2860	10218-10219	HYPH	denotes	/
T2861	10219-10220	SYM	denotes	-
T2858	10221-10225	NNS	denotes	mice
T2863	10225-10227	,	denotes	,
T2864	10227-10228	NN	denotes	U
T2866	10229-10230	SYM	denotes	=
T2865	10231-10235	CD	denotes	0.00
T2867	10235-10236	:	denotes	;
T2868	10237-10238	NN	denotes	p
T2869	10239-10240	SYM	denotes	<
T2862	10241-10245	CD	denotes	0.01
T2870	10245-10246	:	denotes	;
T2871	10247-10250	NN	denotes	D2R
T2873	10250-10251	SYM	denotes	+
T2874	10251-10252	HYPH	denotes	/
T2875	10252-10253	SYM	denotes	+
T2872	10254-10258	NNS	denotes	mice
T2876	10259-10260	NN	denotes	U
T2878	10261-10262	SYM	denotes	=
T2877	10263-10267	CD	denotes	9.00
T2879	10267-10269	,	denotes	,
T2880	10269-10270	NN	denotes	p
T2881	10271-10272	SYM	denotes	<
T2856	10273-10277	CD	denotes	0.05
T2882	10277-10278	-RRB-	denotes	)
T2883	10278-10280	,	denotes	,
T2884	10280-10283	NN	denotes	D2R
T2886	10283-10284	SYM	denotes	-
T2887	10284-10285	HYPH	denotes	/
T2888	10285-10286	SYM	denotes	-
T2885	10287-10291	NNS	denotes	mice
T2889	10292-10301	VBD	denotes	committed
T2890	10302-10306	JJR	denotes	more
T2892	10307-10317	NN	denotes	commission
T2891	10318-10324	NNS	denotes	errors
T2893	10325-10329	IN	denotes	than
T2894	10330-10333	NN	denotes	D2R
T2896	10333-10334	SYM	denotes	+
T2897	10334-10335	HYPH	denotes	/
T2898	10335-10336	SYM	denotes	+
T2895	10337-10341	NNS	denotes	mice
T2899	10342-10343	-LRB-	denotes	(
T2901	10343-10344	NN	denotes	U
T2903	10345-10346	SYM	denotes	=
T2902	10347-10351	CD	denotes	5.00
T2904	10351-10353	,	denotes	,
T2905	10353-10354	NN	denotes	p
T2906	10355-10356	SYM	denotes	<
T2900	10357-10361	CD	denotes	0.05
T2907	10361-10362	-RRB-	denotes	)
T2908	10362-10364	,	denotes	,
T2909	10364-10367	CC	denotes	and
T2910	10368-10373	EX	denotes	there
T2911	10374-10378	VBD	denotes	were
T2912	10379-10381	DT	denotes	no
T2913	10382-10393	NNS	denotes	differences
T2914	10394-10401	IN	denotes	between
T2915	10402-10405	NN	denotes	D2R
T2917	10405-10406	SYM	denotes	-
T2918	10406-10407	HYPH	denotes	/
T2919	10407-10408	SYM	denotes	-
T2920	10409-10412	CC	denotes	and
T2921	10413-10416	NN	denotes	D2R
T2922	10416-10417	SYM	denotes	+
T2923	10417-10418	HYPH	denotes	/
T2924	10418-10419	SYM	denotes	+
T2916	10420-10424	NNS	denotes	mice
T2925	10425-10427	IN	denotes	in
T2926	10428-10436	NN	denotes	omission
T2927	10437-10443	NNS	denotes	errors
T2928	10444-10445	-LRB-	denotes	(
T2930	10445-10446	NN	denotes	U
T2932	10447-10448	SYM	denotes	=
T2931	10449-10453	CD	denotes	27.5
T2933	10453-10455	,	denotes	,
T2934	10455-10456	NN	denotes	p
T2935	10457-10458	SYM	denotes	=
T2929	10459-10463	CD	denotes	0.65
T2936	10463-10464	-RRB-	denotes	)
T2937	10464-10465	.	denotes	.
T2938	10465-10773	sentence	denotes	Moreover, the number of commission errors committed during the first reversal session (an index of stimulus bound perseveration, where all animals are responding to the reversed contingencies for the first time; Fig. 6) indicated a deficit in the D2R-/- mice compared to the D2R+/+ mice (U = 8.5, p < 0.01).
T2939	10466-10474	RB	denotes	Moreover
T2941	10474-10476	,	denotes	,
T2942	10476-10479	DT	denotes	the
T2943	10480-10486	NN	denotes	number
T2944	10487-10489	IN	denotes	of
T2945	10490-10500	NN	denotes	commission
T2946	10501-10507	NNS	denotes	errors
T2947	10508-10517	VBN	denotes	committed
T2948	10518-10524	IN	denotes	during
T2949	10525-10528	DT	denotes	the
T2951	10529-10534	JJ	denotes	first
T2952	10535-10543	NN	denotes	reversal
T2950	10544-10551	NN	denotes	session
T2953	10552-10553	-LRB-	denotes	(
T2954	10553-10555	DT	denotes	an
T2955	10556-10561	NN	denotes	index
T2956	10562-10564	IN	denotes	of
T2957	10565-10573	NN	denotes	stimulus
T2959	10574-10579	VBN	denotes	bound
T2958	10580-10593	NN	denotes	perseveration
T2960	10593-10595	,	denotes	,
T2961	10595-10600	WRB	denotes	where
T2963	10601-10604	DT	denotes	all
T2964	10605-10612	NNS	denotes	animals
T2965	10613-10616	VBP	denotes	are
T2962	10617-10627	VBG	denotes	responding
T2966	10628-10630	IN	denotes	to
T2967	10631-10634	DT	denotes	the
T2969	10635-10643	VBN	denotes	reversed
T2968	10644-10657	NNS	denotes	contingencies
T2970	10658-10661	IN	denotes	for
T2971	10662-10665	DT	denotes	the
T2973	10666-10671	JJ	denotes	first
T2972	10672-10676	NN	denotes	time
T2974	10676-10677	:	denotes	;
T2975	10678-10682	NN	denotes	Fig.
T2976	10683-10684	CD	denotes	6
T2977	10684-10685	-RRB-	denotes	)
T2940	10686-10695	VBD	denotes	indicated
T2978	10696-10697	DT	denotes	a
T2979	10698-10705	NN	denotes	deficit
T2980	10706-10708	IN	denotes	in
T2981	10709-10712	DT	denotes	the
T2983	10713-10716	NN	denotes	D2R
T2984	10716-10717	SYM	denotes	-
T2985	10717-10718	HYPH	denotes	/
T2986	10718-10719	SYM	denotes	-
T2982	10720-10724	NNS	denotes	mice
T2987	10725-10733	VBN	denotes	compared
T2988	10734-10736	IN	denotes	to
T2989	10737-10740	DT	denotes	the
T2991	10741-10744	NN	denotes	D2R
T2992	10744-10745	SYM	denotes	+
T2993	10745-10746	HYPH	denotes	/
T2994	10746-10747	SYM	denotes	+
T2990	10748-10752	NNS	denotes	mice
T2995	10753-10754	-LRB-	denotes	(
T2997	10754-10755	NN	denotes	U
T2999	10756-10757	SYM	denotes	=
T2998	10758-10761	CD	denotes	8.5
T3000	10761-10763	,	denotes	,
T3001	10763-10764	NN	denotes	p
T3002	10765-10766	SYM	denotes	<
T2996	10767-10771	CD	denotes	0.01
T3003	10771-10772	-RRB-	denotes	)
T3004	10772-10773	.	denotes	.
T3005	10773-11013	sentence	denotes	Finally, in an attempt to assess whether perseveration occurred across multiple reversal sessions (Fig. 7), we analyzed the number of commission errors emitted before relearning the reinforcement contingencies during the reversal sessions.
T3006	10774-10781	RB	denotes	Finally
T3008	10781-10783	,	denotes	,
T3009	10783-10785	IN	denotes	in
T3010	10786-10788	DT	denotes	an
T3011	10789-10796	NN	denotes	attempt
T3012	10797-10799	TO	denotes	to
T3013	10800-10806	VB	denotes	assess
T3014	10807-10814	IN	denotes	whether
T3016	10815-10828	NN	denotes	perseveration
T3015	10829-10837	VBD	denotes	occurred
T3017	10838-10844	IN	denotes	across
T3018	10845-10853	JJ	denotes	multiple
T3020	10854-10862	NN	denotes	reversal
T3019	10863-10871	NNS	denotes	sessions
T3021	10872-10873	-LRB-	denotes	(
T3022	10873-10877	NN	denotes	Fig.
T3023	10878-10879	CD	denotes	7
T3024	10879-10880	-RRB-	denotes	)
T3025	10880-10882	,	denotes	,
T3026	10882-10884	PRP	denotes	we
T3007	10885-10893	VBD	denotes	analyzed
T3027	10894-10897	DT	denotes	the
T3028	10898-10904	NN	denotes	number
T3029	10905-10907	IN	denotes	of
T3030	10908-10918	NN	denotes	commission
T3031	10919-10925	NNS	denotes	errors
T3032	10926-10933	VBN	denotes	emitted
T3033	10934-10940	IN	denotes	before
T3034	10941-10951	VBG	denotes	relearning
T3035	10952-10955	DT	denotes	the
T3037	10956-10969	NN	denotes	reinforcement
T3036	10970-10983	NNS	denotes	contingencies
T3038	10984-10990	IN	denotes	during
T3039	10991-10994	DT	denotes	the
T3041	10995-11003	JJ	denotes	reversal
T3040	11004-11012	NNS	denotes	sessions
T3042	11012-11013	.	denotes	.
T3043	11013-11113	sentence	denotes	The data depicted were collected from subjects that had not achieved the 80% performance criterion.
T3044	11014-11017	DT	denotes	The
T3045	11018-11022	NNS	denotes	data
T3047	11023-11031	VBN	denotes	depicted
T3048	11032-11036	VBD	denotes	were
T3046	11037-11046	VBN	denotes	collected
T3049	11047-11051	IN	denotes	from
T3050	11052-11060	NNS	denotes	subjects
T3051	11061-11065	WDT	denotes	that
T3053	11066-11069	VBD	denotes	had
T3054	11070-11073	RB	denotes	not
T3052	11074-11082	VBN	denotes	achieved
T3055	11083-11086	DT	denotes	the
T3057	11087-11089	CD	denotes	80
T3058	11089-11090	NN	denotes	%
T3059	11091-11102	NN	denotes	performance
T3056	11103-11112	NN	denotes	criterion
T3060	11112-11113	.	denotes	.
T3061	11113-11296	sentence	denotes	Therefore, the number of D2R+/+ mice represented in session #1 is 8, in session #2 n = 8, session #3 n = 6 (2 mice met our criterion), in session # 4 n = 5 (three met the criterion).
T3062	11114-11123	RB	denotes	Therefore
T3064	11123-11125	,	denotes	,
T3065	11125-11128	DT	denotes	the
T3066	11129-11135	NN	denotes	number
T3068	11136-11138	IN	denotes	of
T3069	11139-11142	NN	denotes	D2R
T3071	11142-11143	SYM	denotes	+
T3072	11143-11144	HYPH	denotes	/
T3073	11144-11145	SYM	denotes	+
T3070	11146-11150	NNS	denotes	mice
T3074	11151-11162	VBN	denotes	represented
T3075	11163-11165	IN	denotes	in
T3076	11166-11173	NN	denotes	session
T3077	11174-11175	NN	denotes	#
T3078	11175-11176	CD	denotes	1
T3067	11177-11179	VBZ	denotes	is
T3079	11180-11181	CD	denotes	8
T3080	11181-11183	,	denotes	,
T3081	11183-11185	IN	denotes	in
T3083	11186-11193	NN	denotes	session
T3084	11194-11195	NN	denotes	#
T3085	11195-11196	CD	denotes	2
T3086	11197-11198	NN	denotes	n
T3087	11199-11200	SYM	denotes	=
T3082	11201-11202	CD	denotes	8
T3088	11202-11204	,	denotes	,
T3089	11204-11211	NN	denotes	session
T3090	11212-11213	NN	denotes	#
T3092	11213-11214	CD	denotes	3
T3093	11215-11216	NN	denotes	n
T3094	11217-11218	SYM	denotes	=
T3091	11219-11220	CD	denotes	6
T3095	11221-11222	-LRB-	denotes	(
T3097	11222-11223	CD	denotes	2
T3098	11224-11228	NNS	denotes	mice
T3096	11229-11232	VBD	denotes	met
T3099	11233-11236	PRP$	denotes	our
T3100	11237-11246	NN	denotes	criterion
T3101	11246-11247	-RRB-	denotes	)
T3102	11247-11249	,	denotes	,
T3103	11249-11251	IN	denotes	in
T3104	11252-11259	NN	denotes	session
T3105	11260-11261	NN	denotes	#
T3106	11262-11263	CD	denotes	4
T3107	11264-11265	NN	denotes	n
T3108	11266-11267	SYM	denotes	=
T3063	11268-11269	CD	denotes	5
T3109	11270-11271	-LRB-	denotes	(
T3111	11271-11276	CD	denotes	three
T3110	11277-11280	VBD	denotes	met
T3112	11281-11284	DT	denotes	the
T3113	11285-11294	NN	denotes	criterion
T3114	11294-11295	-RRB-	denotes	)
T3115	11295-11296	.	denotes	.
T3116	11296-11363	sentence	denotes	Following session 5, the remaining 5 D2R+/+ mice had met criteria.
T3117	11297-11306	VBG	denotes	Following
T3119	11307-11314	NN	denotes	session
T3120	11315-11316	CD	denotes	5
T3121	11316-11318	,	denotes	,
T3122	11318-11321	DT	denotes	the
T3124	11322-11331	VBG	denotes	remaining
T3125	11332-11333	CD	denotes	5
T3126	11334-11337	NN	denotes	D2R
T3127	11337-11338	SYM	denotes	+
T3128	11338-11339	HYPH	denotes	/
T3129	11339-11340	SYM	denotes	+
T3123	11341-11345	NNS	denotes	mice
T3130	11346-11349	VBD	denotes	had
T3118	11350-11353	VBN	denotes	met
T3131	11354-11362	NNS	denotes	criteria
T3132	11362-11363	.	denotes	.
T3133	11363-11431	sentence	denotes	For the D2R-/- mice, each point on the graph represents 8 subjects.
T3134	11364-11367	IN	denotes	For
T3136	11368-11371	DT	denotes	the
T3138	11372-11375	NN	denotes	D2R
T3139	11375-11376	SYM	denotes	-
T3140	11376-11377	HYPH	denotes	/
T3141	11377-11378	SYM	denotes	-
T3137	11379-11383	NNS	denotes	mice
T3142	11383-11385	,	denotes	,
T3143	11385-11389	DT	denotes	each
T3144	11390-11395	NN	denotes	point
T3145	11396-11398	IN	denotes	on
T3146	11399-11402	DT	denotes	the
T3147	11403-11408	NN	denotes	graph
T3135	11409-11419	VBZ	denotes	represents
T3148	11420-11421	CD	denotes	8
T3149	11422-11430	NNS	denotes	subjects
T3150	11430-11431	.	denotes	.
T3151	11431-11508	sentence	denotes	None of the D2R-/- mice achieved the criterion of 80% accuracy by session 5.
T3152	11432-11436	NN	denotes	None
T3154	11437-11439	IN	denotes	of
T3155	11440-11443	DT	denotes	the
T3157	11444-11447	NN	denotes	D2R
T3158	11447-11448	SYM	denotes	-
T3159	11448-11449	HYPH	denotes	/
T3160	11449-11450	SYM	denotes	-
T3156	11451-11455	NNS	denotes	mice
T3153	11456-11464	VBD	denotes	achieved
T3161	11465-11468	DT	denotes	the
T3162	11469-11478	NN	denotes	criterion
T3163	11479-11481	IN	denotes	of
T3164	11482-11484	CD	denotes	80
T3165	11484-11485	NN	denotes	%
T3166	11486-11494	NN	denotes	accuracy
T3167	11495-11497	IN	denotes	by
T3168	11498-11505	NN	denotes	session
T3169	11506-11507	CD	denotes	5
T3170	11507-11508	.	denotes	.
T3171	11508-11657	sentence	denotes	For the overall 2-way ANOVA, there was a significant difference between genotypes for the number of perseverative errors (F1,51 = 16.61, p < 0.001).
T3172	11509-11512	IN	denotes	For
T3174	11513-11516	DT	denotes	the
T3176	11517-11524	JJ	denotes	overall
T3177	11525-11526	CD	denotes	2
T3179	11526-11527	HYPH	denotes	-
T3178	11527-11530	NN	denotes	way
T3175	11531-11536	NN	denotes	ANOVA
T3180	11536-11538	,	denotes	,
T3181	11538-11543	EX	denotes	there
T3173	11544-11547	VBD	denotes	was
T3182	11548-11549	DT	denotes	a
T3184	11550-11561	JJ	denotes	significant
T3183	11562-11572	NN	denotes	difference
T3185	11573-11580	IN	denotes	between
T3186	11581-11590	NNS	denotes	genotypes
T3187	11591-11594	IN	denotes	for
T3188	11595-11598	DT	denotes	the
T3189	11599-11605	NN	denotes	number
T3190	11606-11608	IN	denotes	of
T3191	11609-11622	JJ	denotes	perseverative
T3192	11623-11629	NNS	denotes	errors
T3193	11630-11631	-LRB-	denotes	(
T3195	11631-11633	NN	denotes	F1
T3197	11633-11634	,	denotes	,
T3198	11634-11636	CD	denotes	51
T3199	11637-11638	SYM	denotes	=
T3196	11639-11644	CD	denotes	16.61
T3200	11644-11646	,	denotes	,
T3201	11646-11647	NN	denotes	p
T3202	11648-11649	SYM	denotes	<
T3194	11650-11655	CD	denotes	0.001
T3203	11655-11656	-RRB-	denotes	)
T3204	11656-11657	.	denotes	.
T4023	11670-11672	IN	denotes	In
T4025	11673-11677	DT	denotes	this
T4026	11678-11683	NN	denotes	study
T4027	11683-11685	,	denotes	,
T4028	11685-11687	PRP	denotes	we
T4024	11688-11694	VBD	denotes	sought
T4029	11695-11697	TO	denotes	to
T4030	11698-11707	VB	denotes	determine
T4031	11708-11711	DT	denotes	the
T4032	11712-11724	NN	denotes	contribution
T4033	11725-11727	IN	denotes	of
T4034	11728-11736	NN	denotes	dopamine
T4035	11737-11739	NN	denotes	D2
T4036	11740-11748	NN	denotes	receptor
T4038	11748-11749	HYPH	denotes	-
T4037	11749-11757	VBN	denotes	mediated
T4039	11758-11767	NN	denotes	signaling
T4040	11768-11770	IN	denotes	to
T4041	11771-11774	DT	denotes	the
T4043	11775-11782	JJ	denotes	various
T4042	11783-11789	NNS	denotes	stages
T4044	11790-11792	IN	denotes	of
T4045	11793-11804	JJ	denotes	associative
T4047	11805-11808	CC	denotes	and
T4048	11809-11817	NN	denotes	reversal
T4046	11818-11826	NN	denotes	learning
T4049	11826-11827	.	denotes	.
T4050	11827-12084	sentence	denotes	D2R-/- mice demonstrated that they were capable of learning to locate and consume food pellets, indicating that their locomotor behavior was not detectably disrupted and their primary motivation to obtain a natural reinforcer (food pellet) was undisturbed.
T4051	11828-11831	NN	denotes	D2R
T4053	11831-11832	SYM	denotes	-
T4054	11832-11833	HYPH	denotes	/
T4055	11833-11834	SYM	denotes	-
T4052	11835-11839	NNS	denotes	mice
T4056	11840-11852	VBD	denotes	demonstrated
T4057	11853-11857	IN	denotes	that
T4059	11858-11862	PRP	denotes	they
T4058	11863-11867	VBD	denotes	were
T4060	11868-11875	JJ	denotes	capable
T4061	11876-11878	IN	denotes	of
T4062	11879-11887	VBG	denotes	learning
T4063	11888-11890	TO	denotes	to
T4064	11891-11897	VB	denotes	locate
T4065	11898-11901	CC	denotes	and
T4066	11902-11909	VB	denotes	consume
T4067	11910-11914	NN	denotes	food
T4068	11915-11922	NNS	denotes	pellets
T4069	11922-11924	,	denotes	,
T4070	11924-11934	VBG	denotes	indicating
T4071	11935-11939	IN	denotes	that
T4073	11940-11945	PRP$	denotes	their
T4075	11946-11955	NN	denotes	locomotor
T4074	11956-11964	NN	denotes	behavior
T4076	11965-11968	VBD	denotes	was
T4077	11969-11972	RB	denotes	not
T4078	11973-11983	RB	denotes	detectably
T4072	11984-11993	VBN	denotes	disrupted
T4079	11994-11997	CC	denotes	and
T4080	11998-12003	PRP$	denotes	their
T4082	12004-12011	JJ	denotes	primary
T4081	12012-12022	NN	denotes	motivation
T4084	12023-12025	TO	denotes	to
T4085	12026-12032	VB	denotes	obtain
T4086	12033-12034	DT	denotes	a
T4088	12035-12042	JJ	denotes	natural
T4087	12043-12053	NN	denotes	reinforcer
T4089	12054-12055	-LRB-	denotes	(
T4090	12055-12059	NN	denotes	food
T4091	12060-12066	NN	denotes	pellet
T4092	12066-12067	-RRB-	denotes	)
T4083	12068-12071	VBD	denotes	was
T4093	12072-12083	JJ	denotes	undisturbed
T4094	12083-12084	.	denotes	.
T4095	12084-12352	sentence	denotes	Rather, the impaired ability of D2R-/- mice to assign appropriate discriminative stimulus relationships in an operant discrimination task argues that D2R-mediated signaling contributes to the neuronal processes involved in attaching salience to environmental stimuli.
T4096	12085-12091	RB	denotes	Rather
T4098	12091-12093	,	denotes	,
T4099	12093-12096	DT	denotes	the
T4101	12097-12105	JJ	denotes	impaired
T4100	12106-12113	NN	denotes	ability
T4102	12114-12116	IN	denotes	of
T4103	12117-12120	NN	denotes	D2R
T4105	12120-12121	SYM	denotes	-
T4106	12121-12122	HYPH	denotes	/
T4107	12122-12123	SYM	denotes	-
T4104	12124-12128	NNS	denotes	mice
T4108	12129-12131	TO	denotes	to
T4109	12132-12138	VB	denotes	assign
T4110	12139-12150	JJ	denotes	appropriate
T4112	12151-12165	JJ	denotes	discriminative
T4113	12166-12174	NN	denotes	stimulus
T4111	12175-12188	NNS	denotes	relationships
T4114	12189-12191	IN	denotes	in
T4115	12192-12194	DT	denotes	an
T4117	12195-12202	NN	denotes	operant
T4118	12203-12217	NN	denotes	discrimination
T4116	12218-12222	NN	denotes	task
T4097	12223-12229	VBZ	denotes	argues
T4119	12230-12234	IN	denotes	that
T4121	12235-12238	NN	denotes	D2R
T4123	12238-12239	HYPH	denotes	-
T4122	12239-12247	VBN	denotes	mediated
T4124	12248-12257	NN	denotes	signaling
T4120	12258-12269	VBZ	denotes	contributes
T4125	12270-12272	IN	denotes	to
T4126	12273-12276	DT	denotes	the
T4128	12277-12285	JJ	denotes	neuronal
T4127	12286-12295	NNS	denotes	processes
T4129	12296-12304	VBN	denotes	involved
T4130	12305-12307	IN	denotes	in
T4131	12308-12317	VBG	denotes	attaching
T4132	12318-12326	NN	denotes	salience
T4133	12327-12329	IN	denotes	to
T4134	12330-12343	JJ	denotes	environmental
T4135	12344-12351	NNS	denotes	stimuli
T4136	12351-12352	.	denotes	.
T4137	12352-12570	sentence	denotes	The deficient capacity of D2R-/- mice to disengage inappropriate decision strategies strongly argues that mesolimbic dopamine signaling, mediated by dopamine D2Rs is essential for efficient reversal learning to occur.
T4138	12353-12356	DT	denotes	The
T4140	12357-12366	JJ	denotes	deficient
T4139	12367-12375	NN	denotes	capacity
T4142	12376-12378	IN	denotes	of
T4143	12379-12382	NN	denotes	D2R
T4145	12382-12383	SYM	denotes	-
T4146	12383-12384	HYPH	denotes	/
T4147	12384-12385	SYM	denotes	-
T4144	12386-12390	NNS	denotes	mice
T4148	12391-12393	TO	denotes	to
T4149	12394-12403	VB	denotes	disengage
T4150	12404-12417	JJ	denotes	inappropriate
T4152	12418-12426	NN	denotes	decision
T4151	12427-12437	NNS	denotes	strategies
T4153	12438-12446	RB	denotes	strongly
T4141	12447-12453	VBZ	denotes	argues
T4154	12454-12458	IN	denotes	that
T4156	12459-12469	JJ	denotes	mesolimbic
T4158	12470-12478	NN	denotes	dopamine
T4157	12479-12488	NN	denotes	signaling
T4159	12488-12490	,	denotes	,
T4160	12490-12498	VBN	denotes	mediated
T4161	12499-12501	IN	denotes	by
T4162	12502-12510	NN	denotes	dopamine
T4163	12511-12515	NNS	denotes	D2Rs
T4155	12516-12518	VBZ	denotes	is
T4164	12519-12528	JJ	denotes	essential
T4165	12529-12532	IN	denotes	for
T4167	12533-12542	JJ	denotes	efficient
T4169	12543-12551	NN	denotes	reversal
T4168	12552-12560	NN	denotes	learning
T4170	12561-12563	TO	denotes	to
T4166	12564-12569	VB	denotes	occur
T4171	12569-12570	.	denotes	.
T4172	12570-12777	sentence	denotes	Mice with or without intact dopamine D2R-mediated signaling displayed similar decreases in latencies to retrieve unhidden food pellets (Fig. 1) and learned to dig for food buried in unscented sand (Fig. 2).
T4173	12571-12575	NNS	denotes	Mice
T4175	12576-12580	IN	denotes	with
T4176	12581-12583	CC	denotes	or
T4177	12584-12591	IN	denotes	without
T4178	12592-12598	JJ	denotes	intact
T4180	12599-12607	NN	denotes	dopamine
T4181	12608-12611	NN	denotes	D2R
T4183	12611-12612	HYPH	denotes	-
T4182	12612-12620	VBN	denotes	mediated
T4179	12621-12630	NN	denotes	signaling
T4174	12631-12640	VBD	denotes	displayed
T4184	12641-12648	JJ	denotes	similar
T4185	12649-12658	NNS	denotes	decreases
T4186	12659-12661	IN	denotes	in
T4187	12662-12671	NNS	denotes	latencies
T4188	12672-12674	TO	denotes	to
T4189	12675-12683	VB	denotes	retrieve
T4190	12684-12692	JJ	denotes	unhidden
T4192	12693-12697	NN	denotes	food
T4191	12698-12705	NNS	denotes	pellets
T4193	12706-12707	-LRB-	denotes	(
T4194	12707-12711	NN	denotes	Fig.
T4195	12712-12713	CD	denotes	1
T4196	12713-12714	-RRB-	denotes	)
T4197	12715-12718	CC	denotes	and
T4198	12719-12726	VBD	denotes	learned
T4199	12727-12729	TO	denotes	to
T4200	12730-12733	VB	denotes	dig
T4201	12734-12737	IN	denotes	for
T4202	12738-12742	NN	denotes	food
T4203	12743-12749	VBN	denotes	buried
T4204	12750-12752	IN	denotes	in
T4205	12753-12762	JJ	denotes	unscented
T4206	12763-12767	NN	denotes	sand
T4207	12768-12769	-LRB-	denotes	(
T4208	12769-12773	NN	denotes	Fig.
T4209	12774-12775	CD	denotes	2
T4210	12775-12776	-RRB-	denotes	)
T4211	12776-12777	.	denotes	.
T4212	12777-13005	sentence	denotes	These findings are in complete agreement with earlier studies that utilized rats and fairly selective D2R antagonists [3-8], as well as even very extensive 6-OHDA lesions [1,10,11] in associative and operant learning paradigms.
T4213	12778-12783	DT	denotes	These
T4214	12784-12792	NNS	denotes	findings
T4215	12793-12796	VBP	denotes	are
T4216	12797-12799	IN	denotes	in
T4217	12800-12808	JJ	denotes	complete
T4218	12809-12818	NN	denotes	agreement
T4219	12819-12823	IN	denotes	with
T4220	12824-12831	JJR	denotes	earlier
T4221	12832-12839	NNS	denotes	studies
T4222	12840-12844	WDT	denotes	that
T4223	12845-12853	VBD	denotes	utilized
T4224	12854-12858	NNS	denotes	rats
T4225	12859-12862	CC	denotes	and
T4226	12863-12869	RB	denotes	fairly
T4227	12870-12879	JJ	denotes	selective
T4229	12880-12883	NN	denotes	D2R
T4228	12884-12895	NNS	denotes	antagonists
T4230	12896-12897	-LRB-	denotes	[
T4231	12897-12898	CD	denotes	3
T4232	12898-12899	SYM	denotes	-
T4233	12899-12900	CD	denotes	8
T4234	12900-12901	-RRB-	denotes	]
T4235	12901-12903	,	denotes	,
T4236	12903-12905	RB	denotes	as
T4238	12906-12910	RB	denotes	well
T4237	12911-12913	IN	denotes	as
T4239	12914-12918	RB	denotes	even
T4241	12919-12923	RB	denotes	very
T4242	12924-12933	JJ	denotes	extensive
T4243	12934-12935	CD	denotes	6
T4245	12935-12936	HYPH	denotes	-
T4244	12936-12940	NN	denotes	OHDA
T4240	12941-12948	NNS	denotes	lesions
T4246	12949-12950	-LRB-	denotes	[
T4248	12950-12951	CD	denotes	1
T4249	12951-12952	,	denotes	,
T4250	12952-12954	CD	denotes	10
T4251	12954-12955	,	denotes	,
T4247	12955-12957	CD	denotes	11
T4252	12957-12958	-RRB-	denotes	]
T4253	12959-12961	IN	denotes	in
T4254	12962-12973	JJ	denotes	associative
T4256	12974-12977	CC	denotes	and
T4257	12978-12985	NN	denotes	operant
T4258	12986-12994	NN	denotes	learning
T4255	12995-13004	NNS	denotes	paradigms
T4259	13004-13005	.	denotes	.
T4260	13005-13193	sentence	denotes	Our results add to a growing literature demonstrating a negligible role of dopamine, and now, specifically, D2Rs in the unconditioned or hedonic value of natural (food) reinforcers [1,2].
T4261	13006-13009	PRP$	denotes	Our
T4262	13010-13017	NNS	denotes	results
T4263	13018-13021	VBP	denotes	add
T4264	13022-13024	IN	denotes	to
T4265	13025-13026	DT	denotes	a
T4267	13027-13034	VBG	denotes	growing
T4266	13035-13045	NN	denotes	literature
T4268	13046-13059	VBG	denotes	demonstrating
T4269	13060-13061	DT	denotes	a
T4271	13062-13072	JJ	denotes	negligible
T4270	13073-13077	NN	denotes	role
T4272	13078-13080	IN	denotes	of
T4273	13081-13089	NN	denotes	dopamine
T4274	13089-13091	,	denotes	,
T4275	13091-13094	CC	denotes	and
T4276	13095-13098	RB	denotes	now
T4278	13098-13100	,	denotes	,
T4279	13100-13112	RB	denotes	specifically
T4280	13112-13114	,	denotes	,
T4277	13114-13118	NNS	denotes	D2Rs
T4281	13119-13121	IN	denotes	in
T4282	13122-13125	DT	denotes	the
T4284	13126-13139	JJ	denotes	unconditioned
T4285	13140-13142	CC	denotes	or
T4286	13143-13150	JJ	denotes	hedonic
T4283	13151-13156	NN	denotes	value
T4287	13157-13159	IN	denotes	of
T4288	13160-13167	JJ	denotes	natural
T4290	13168-13169	-LRB-	denotes	(
T4291	13169-13173	NN	denotes	food
T4292	13173-13174	-RRB-	denotes	)
T4289	13175-13186	NNS	denotes	reinforcers
T4293	13187-13188	-LRB-	denotes	[
T4295	13188-13189	CD	denotes	1
T4296	13189-13190	,	denotes	,
T4294	13190-13191	CD	denotes	2
T4297	13191-13192	-RRB-	denotes	]
T4298	13192-13193	.	denotes	.
T4299	13193-13374	sentence	denotes	The comparatively poor skill of D2R-/- mice during discrimination trials suggests a role for D2Rs in acquisition of appropriate S+/S- relationships in operant associative learning.
T4300	13194-13197	DT	denotes	The
T4302	13198-13211	RB	denotes	comparatively
T4303	13212-13216	JJ	denotes	poor
T4301	13217-13222	NN	denotes	skill
T4305	13223-13225	IN	denotes	of
T4306	13226-13229	NN	denotes	D2R
T4308	13229-13230	SYM	denotes	-
T4309	13230-13231	HYPH	denotes	/
T4310	13231-13232	SYM	denotes	-
T4307	13233-13237	NNS	denotes	mice
T4311	13238-13244	IN	denotes	during
T4312	13245-13259	NN	denotes	discrimination
T4313	13260-13266	NNS	denotes	trials
T4304	13267-13275	VBZ	denotes	suggests
T4314	13276-13277	DT	denotes	a
T4315	13278-13282	NN	denotes	role
T4316	13283-13286	IN	denotes	for
T4317	13287-13291	NNS	denotes	D2Rs
T4318	13292-13294	IN	denotes	in
T4319	13295-13306	NN	denotes	acquisition
T4320	13307-13309	IN	denotes	of
T4321	13310-13321	JJ	denotes	appropriate
T4323	13322-13323	NN	denotes	S
T4324	13323-13324	SYM	denotes	+
T4325	13324-13325	HYPH	denotes	/
T4326	13325-13326	NN	denotes	S
T4327	13326-13327	SYM	denotes	-
T4322	13328-13341	NNS	denotes	relationships
T4328	13342-13344	IN	denotes	in
T4329	13345-13352	NN	denotes	operant
T4331	13353-13364	JJ	denotes	associative
T4330	13365-13373	NN	denotes	learning
T4332	13373-13374	.	denotes	.
T4333	13374-13514	sentence	denotes	Several studies have demonstrated that both the acquisition [6,7] and expression [9] of associative learning are mediated by dopamine D1Rs.
T4334	13375-13382	JJ	denotes	Several
T4335	13383-13390	NNS	denotes	studies
T4337	13391-13395	VBP	denotes	have
T4336	13396-13408	VBN	denotes	demonstrated
T4338	13409-13413	IN	denotes	that
T4340	13414-13418	CC	denotes	both
T4342	13419-13422	DT	denotes	the
T4341	13423-13434	NN	denotes	acquisition
T4343	13435-13436	-LRB-	denotes	[
T4345	13436-13437	CD	denotes	6
T4346	13437-13438	,	denotes	,
T4344	13438-13439	CD	denotes	7
T4347	13439-13440	-RRB-	denotes	]
T4348	13441-13444	CC	denotes	and
T4349	13445-13455	NN	denotes	expression
T4350	13456-13457	-LRB-	denotes	[
T4351	13457-13458	CD	denotes	9
T4352	13458-13459	-RRB-	denotes	]
T4353	13460-13462	IN	denotes	of
T4354	13463-13474	JJ	denotes	associative
T4355	13475-13483	NN	denotes	learning
T4356	13484-13487	VBP	denotes	are
T4339	13488-13496	VBN	denotes	mediated
T4357	13497-13499	IN	denotes	by
T4358	13500-13508	NN	denotes	dopamine
T4359	13509-13513	NNS	denotes	D1Rs
T4360	13513-13514	.	denotes	.
T4361	13514-13644	sentence	denotes	Most literature reviews identify dopamine D1Rs with dopamine-mediated learning and D2Rs with motor related behaviors [e.g. [24]].
T4362	13515-13519	JJS	denotes	Most
T4364	13520-13530	NN	denotes	literature
T4363	13531-13538	NNS	denotes	reviews
T4365	13539-13547	VBP	denotes	identify
T4366	13548-13556	NN	denotes	dopamine
T4367	13557-13561	NNS	denotes	D1Rs
T4368	13562-13566	IN	denotes	with
T4369	13567-13575	NN	denotes	dopamine
T4371	13575-13576	HYPH	denotes	-
T4370	13576-13584	VBN	denotes	mediated
T4372	13585-13593	NN	denotes	learning
T4373	13594-13597	CC	denotes	and
T4374	13598-13602	NNS	denotes	D2Rs
T4375	13603-13607	IN	denotes	with
T4376	13608-13613	NN	denotes	motor
T4377	13614-13621	VBN	denotes	related
T4378	13622-13631	NNS	denotes	behaviors
T4379	13632-13633	-LRB-	denotes	[
T4381	13633-13637	FW	denotes	e.g.
T4382	13638-13639	-LRB-	denotes	[
T4380	13639-13641	CD	denotes	24
T4383	13641-13642	-RRB-	denotes	]
T4384	13642-13643	-RRB-	denotes	]
T4385	13643-13644	.	denotes	.
T4386	13644-13820	sentence	denotes	Moreover, it has been reported that acute administration of the dopamine D2/3 antagonist, raclopride, actually improves acquisition of food-motivated associative learning [6].
T4387	13645-13653	RB	denotes	Moreover
T4389	13653-13655	,	denotes	,
T4390	13655-13657	PRP	denotes	it
T4391	13658-13661	VBZ	denotes	has
T4392	13662-13666	VBN	denotes	been
T4388	13667-13675	VBN	denotes	reported
T4393	13676-13680	IN	denotes	that
T4395	13681-13686	JJ	denotes	acute
T4396	13687-13701	NN	denotes	administration
T4397	13702-13704	IN	denotes	of
T4398	13705-13708	DT	denotes	the
T4400	13709-13717	NN	denotes	dopamine
T4401	13718-13720	NN	denotes	D2
T4402	13720-13721	HYPH	denotes	/
T4403	13721-13722	CD	denotes	3
T4399	13723-13733	NN	denotes	antagonist
T4404	13733-13735	,	denotes	,
T4405	13735-13745	NN	denotes	raclopride
T4406	13745-13747	,	denotes	,
T4407	13747-13755	RB	denotes	actually
T4394	13756-13764	VBZ	denotes	improves
T4408	13765-13776	NN	denotes	acquisition
T4409	13777-13779	IN	denotes	of
T4410	13780-13784	NN	denotes	food
T4412	13784-13785	HYPH	denotes	-
T4411	13785-13794	VBN	denotes	motivated
T4414	13795-13806	JJ	denotes	associative
T4413	13807-13815	NN	denotes	learning
T4415	13816-13817	-LRB-	denotes	[
T4416	13817-13818	CD	denotes	6
T4417	13818-13819	-RRB-	denotes	]
T4418	13819-13820	.	denotes	.
T4419	13820-13954	sentence	denotes	However, only acute administrations of antagonists were given, and learning was not measured during complete D1R or D2R blockade [6].
T4420	13821-13828	RB	denotes	However
T4422	13828-13830	,	denotes	,
T4423	13830-13834	RB	denotes	only
T4425	13835-13840	JJ	denotes	acute
T4424	13841-13856	NNS	denotes	administrations
T4426	13857-13859	IN	denotes	of
T4427	13860-13871	NNS	denotes	antagonists
T4428	13872-13876	VBD	denotes	were
T4421	13877-13882	VBN	denotes	given
T4429	13882-13884	,	denotes	,
T4430	13884-13887	CC	denotes	and
T4431	13888-13896	NN	denotes	learning
T4433	13897-13900	VBD	denotes	was
T4434	13901-13904	RB	denotes	not
T4432	13905-13913	VBN	denotes	measured
T4435	13914-13920	IN	denotes	during
T4436	13921-13929	JJ	denotes	complete
T4438	13930-13933	NN	denotes	D1R
T4439	13934-13936	CC	denotes	or
T4440	13937-13940	NN	denotes	D2R
T4437	13941-13949	NN	denotes	blockade
T4441	13950-13951	-LRB-	denotes	[
T4442	13951-13952	CD	denotes	6
T4443	13952-13953	-RRB-	denotes	]
T4444	13953-13954	.	denotes	.
T4445	13954-14289	sentence	denotes	Significantly, the reports cited above failed to address the technical limitations of the approach: i.e. that the antagonists used lack adequate subtype specificity and only partially blocked D2R-mediated signaling thus making it impossible to rigorously assess the role of D2R-mediated signaling in associative and reversal learning.
T4446	13955-13968	RB	denotes	Significantly
T4448	13968-13970	,	denotes	,
T4449	13970-13973	DT	denotes	the
T4450	13974-13981	NNS	denotes	reports
T4451	13982-13987	VBD	denotes	cited
T4452	13988-13993	RB	denotes	above
T4447	13994-14000	VBD	denotes	failed
T4453	14001-14003	TO	denotes	to
T4454	14004-14011	VB	denotes	address
T4455	14012-14015	DT	denotes	the
T4457	14016-14025	JJ	denotes	technical
T4456	14026-14037	NNS	denotes	limitations
T4458	14038-14040	IN	denotes	of
T4459	14041-14044	DT	denotes	the
T4460	14045-14053	NN	denotes	approach
T4461	14053-14055	:	denotes	:
T4462	14055-14059	FW	denotes	i.e.
T4464	14060-14064	IN	denotes	that
T4465	14065-14068	DT	denotes	the
T4466	14069-14080	NNS	denotes	antagonists
T4467	14081-14085	VBN	denotes	used
T4463	14086-14090	VBP	denotes	lack
T4468	14091-14099	JJ	denotes	adequate
T4470	14100-14107	NN	denotes	subtype
T4469	14108-14119	NN	denotes	specificity
T4471	14120-14123	CC	denotes	and
T4472	14124-14128	RB	denotes	only
T4473	14129-14138	RB	denotes	partially
T4474	14139-14146	VBD	denotes	blocked
T4475	14147-14150	NN	denotes	D2R
T4477	14150-14151	HYPH	denotes	-
T4476	14151-14159	VBN	denotes	mediated
T4478	14160-14169	NN	denotes	signaling
T4479	14170-14174	RB	denotes	thus
T4480	14175-14181	VBG	denotes	making
T4481	14182-14184	PRP	denotes	it
T4482	14185-14195	JJ	denotes	impossible
T4483	14196-14198	TO	denotes	to
T4485	14199-14209	RB	denotes	rigorously
T4484	14210-14216	VB	denotes	assess
T4486	14217-14220	DT	denotes	the
T4487	14221-14225	NN	denotes	role
T4488	14226-14228	IN	denotes	of
T4489	14229-14232	NN	denotes	D2R
T4491	14232-14233	HYPH	denotes	-
T4490	14233-14241	VBN	denotes	mediated
T4492	14242-14251	NN	denotes	signaling
T4493	14252-14254	IN	denotes	in
T4494	14255-14266	JJ	denotes	associative
T4496	14267-14270	CC	denotes	and
T4497	14271-14279	NN	denotes	reversal
T4495	14280-14288	NN	denotes	learning
T4498	14288-14289	.	denotes	.
T4499	14289-14477	sentence	denotes	Additionally, none of these studies addressed the observation that the effects of D2R antagonists on locomotion and learning depend on whether exposure is chronic or acute [e.g. [15,16]].
T4500	14290-14302	RB	denotes	Additionally
T4502	14302-14304	,	denotes	,
T4503	14304-14308	NN	denotes	none
T4504	14309-14311	IN	denotes	of
T4505	14312-14317	DT	denotes	these
T4506	14318-14325	NNS	denotes	studies
T4501	14326-14335	VBD	denotes	addressed
T4507	14336-14339	DT	denotes	the
T4508	14340-14351	NN	denotes	observation
T4509	14352-14356	IN	denotes	that
T4511	14357-14360	DT	denotes	the
T4512	14361-14368	NNS	denotes	effects
T4513	14369-14371	IN	denotes	of
T4514	14372-14375	NN	denotes	D2R
T4515	14376-14387	NNS	denotes	antagonists
T4516	14388-14390	IN	denotes	on
T4517	14391-14401	NN	denotes	locomotion
T4518	14402-14405	CC	denotes	and
T4519	14406-14414	NN	denotes	learning
T4510	14415-14421	VBP	denotes	depend
T4520	14422-14424	IN	denotes	on
T4521	14425-14432	IN	denotes	whether
T4523	14433-14441	NN	denotes	exposure
T4522	14442-14444	VBZ	denotes	is
T4524	14445-14452	JJ	denotes	chronic
T4525	14453-14455	CC	denotes	or
T4526	14456-14461	JJ	denotes	acute
T4527	14462-14463	-LRB-	denotes	[
T4529	14463-14467	FW	denotes	e.g.
T4530	14468-14469	-LRB-	denotes	[
T4531	14469-14471	CD	denotes	15
T4532	14471-14472	,	denotes	,
T4528	14472-14474	CD	denotes	16
T4533	14474-14475	-RRB-	denotes	]
T4534	14475-14476	-RRB-	denotes	]
T4535	14476-14477	.	denotes	.
T4536	14477-14768	sentence	denotes	That D2R-mediated signaling orchestrates just motor components of learning is a conclusion that is potentially biased due to the practice of avoiding doses of drugs that induce catalepsy (and therefore measuring only partial blockade of dopamine D2Rs) and single administrations [e.g. [3]].
T4537	14478-14482	IN	denotes	That
T4539	14483-14486	NN	denotes	D2R
T4541	14486-14487	HYPH	denotes	-
T4540	14487-14495	VBN	denotes	mediated
T4542	14496-14505	NN	denotes	signaling
T4538	14506-14518	VBZ	denotes	orchestrates
T4544	14519-14523	RB	denotes	just
T4546	14524-14529	JJ	denotes	motor
T4545	14530-14540	NNS	denotes	components
T4547	14541-14543	IN	denotes	of
T4548	14544-14552	NN	denotes	learning
T4543	14553-14555	VBZ	denotes	is
T4549	14556-14557	DT	denotes	a
T4550	14558-14568	NN	denotes	conclusion
T4551	14569-14573	WDT	denotes	that
T4552	14574-14576	VBZ	denotes	is
T4553	14577-14588	RB	denotes	potentially
T4554	14589-14595	VBN	denotes	biased
T4555	14596-14599	IN	denotes	due
T4556	14600-14602	IN	denotes	to
T4557	14603-14606	DT	denotes	the
T4558	14607-14615	NN	denotes	practice
T4559	14616-14618	IN	denotes	of
T4560	14619-14627	VBG	denotes	avoiding
T4561	14628-14633	NNS	denotes	doses
T4562	14634-14636	IN	denotes	of
T4563	14637-14642	NNS	denotes	drugs
T4564	14643-14647	WDT	denotes	that
T4565	14648-14654	VBP	denotes	induce
T4566	14655-14664	NN	denotes	catalepsy
T4567	14665-14666	-LRB-	denotes	(
T4568	14666-14669	CC	denotes	and
T4569	14670-14679	RB	denotes	therefore
T4570	14680-14689	VBG	denotes	measuring
T4571	14690-14694	RB	denotes	only
T4573	14695-14702	JJ	denotes	partial
T4572	14703-14711	NN	denotes	blockade
T4574	14712-14714	IN	denotes	of
T4575	14715-14723	NN	denotes	dopamine
T4576	14724-14728	NNS	denotes	D2Rs
T4577	14728-14729	-RRB-	denotes	)
T4578	14730-14733	CC	denotes	and
T4579	14734-14740	JJ	denotes	single
T4580	14741-14756	NNS	denotes	administrations
T4581	14757-14758	-LRB-	denotes	[
T4583	14758-14762	FW	denotes	e.g.
T4584	14763-14764	-LRB-	denotes	[
T4582	14764-14765	CD	denotes	3
T4585	14765-14766	-RRB-	denotes	]
T4586	14766-14767	-RRB-	denotes	]
T4587	14767-14768	.	denotes	.
T4588	14768-14912	sentence	denotes	Quite possibly, the functional role of D2Rs in associative learning might be masked because of this concern about locomotor disruption [2,6,8].
T4589	14769-14774	RB	denotes	Quite
T4590	14775-14783	RB	denotes	possibly
T4592	14783-14785	,	denotes	,
T4593	14785-14788	DT	denotes	the
T4595	14789-14799	JJ	denotes	functional
T4594	14800-14804	NN	denotes	role
T4596	14805-14807	IN	denotes	of
T4597	14808-14812	NNS	denotes	D2Rs
T4598	14813-14815	IN	denotes	in
T4599	14816-14827	JJ	denotes	associative
T4600	14828-14836	NN	denotes	learning
T4601	14837-14842	MD	denotes	might
T4602	14843-14845	VB	denotes	be
T4591	14846-14852	VBN	denotes	masked
T4603	14853-14860	RB	denotes	because
T4604	14861-14863	IN	denotes	of
T4605	14864-14868	DT	denotes	this
T4606	14869-14876	NN	denotes	concern
T4607	14877-14882	IN	denotes	about
T4608	14883-14892	NN	denotes	locomotor
T4609	14893-14903	NN	denotes	disruption
T4610	14904-14905	-LRB-	denotes	[
T4612	14905-14906	CD	denotes	2
T4613	14906-14907	,	denotes	,
T4614	14907-14908	CD	denotes	6
T4615	14908-14909	,	denotes	,
T4611	14909-14910	CD	denotes	8
T4616	14910-14911	-RRB-	denotes	]
T4617	14911-14912	.	denotes	.
T4618	14912-15080	sentence	denotes	Doses of raclopride as low as 0.5 mg/kg significantly disrupt motor behavior [25], although this peripheral dose is consistently used in learning paradigms [e.g. [6]].
T4619	14913-14918	NNS	denotes	Doses
T4621	14919-14921	IN	denotes	of
T4622	14922-14932	NN	denotes	raclopride
T4623	14933-14935	RB	denotes	as
T4625	14936-14939	JJ	denotes	low
T4626	14940-14942	IN	denotes	as
T4624	14943-14946	CD	denotes	0.5
T4627	14947-14949	NNS	denotes	mg
T4628	14949-14950	SYM	denotes	/
T4629	14950-14952	NN	denotes	kg
T4630	14953-14966	RB	denotes	significantly
T4620	14967-14974	VBP	denotes	disrupt
T4631	14975-14980	JJ	denotes	motor
T4632	14981-14989	NN	denotes	behavior
T4633	14990-14991	-LRB-	denotes	[
T4634	14991-14993	CD	denotes	25
T4635	14993-14994	-RRB-	denotes	]
T4636	14994-14996	,	denotes	,
T4637	14996-15004	IN	denotes	although
T4639	15005-15009	DT	denotes	this
T4641	15010-15020	JJ	denotes	peripheral
T4640	15021-15025	NN	denotes	dose
T4642	15026-15028	VBZ	denotes	is
T4643	15029-15041	RB	denotes	consistently
T4638	15042-15046	VBN	denotes	used
T4644	15047-15049	IN	denotes	in
T4645	15050-15058	VBG	denotes	learning
T4646	15059-15068	NNS	denotes	paradigms
T4647	15069-15070	-LRB-	denotes	[
T4649	15070-15074	FW	denotes	e.g.
T4650	15075-15076	-LRB-	denotes	[
T4648	15076-15077	CD	denotes	6
T4651	15077-15078	-RRB-	denotes	]
T4652	15078-15079	-RRB-	denotes	]
T4653	15079-15080	.	denotes	.
T4654	15080-15194	sentence	denotes	One might then ask: "How then could the role of D2Rs in associative learning be dissociated from motor behavior?"
T4655	15081-15084	PRP	denotes	One
T4657	15085-15090	MD	denotes	might
T4658	15091-15095	RB	denotes	then
T4656	15096-15099	VB	denotes	ask
T4659	15099-15101	:	denotes	:
T4660	15101-15102	``	denotes	"
T4661	15102-15105	WRB	denotes	How
T4663	15106-15110	RB	denotes	then
T4664	15111-15116	MD	denotes	could
T4665	15117-15120	DT	denotes	the
T4666	15121-15125	NN	denotes	role
T4667	15126-15128	IN	denotes	of
T4668	15129-15133	NNS	denotes	D2Rs
T4669	15134-15136	IN	denotes	in
T4670	15137-15148	JJ	denotes	associative
T4671	15149-15157	NN	denotes	learning
T4672	15158-15160	VB	denotes	be
T4662	15161-15172	VBN	denotes	dissociated
T4673	15173-15177	IN	denotes	from
T4674	15178-15183	JJ	denotes	motor
T4675	15184-15192	NN	denotes	behavior
T4676	15192-15193	.	denotes	?
T4677	15193-15194	''	denotes	"
T4678	15194-15399	sentence	denotes	Seminal experiments [26-28] have clearly demonstrated that repeated administration of catalepsy-inducing doses of D2R antagonists in rodents actually leads to a striking behavioral tolerance to catalepsy.
T4679	15195-15202	JJ	denotes	Seminal
T4680	15203-15214	NNS	denotes	experiments
T4682	15215-15216	-LRB-	denotes	[
T4683	15216-15218	CD	denotes	26
T4684	15218-15219	SYM	denotes	-
T4685	15219-15221	CD	denotes	28
T4686	15221-15222	-RRB-	denotes	]
T4687	15223-15227	VBP	denotes	have
T4688	15228-15235	RB	denotes	clearly
T4681	15236-15248	VBN	denotes	demonstrated
T4689	15249-15253	IN	denotes	that
T4691	15254-15262	JJ	denotes	repeated
T4692	15263-15277	NN	denotes	administration
T4693	15278-15280	IN	denotes	of
T4694	15281-15290	NN	denotes	catalepsy
T4696	15290-15291	HYPH	denotes	-
T4695	15291-15299	VBG	denotes	inducing
T4697	15300-15305	NNS	denotes	doses
T4698	15306-15308	IN	denotes	of
T4699	15309-15312	NN	denotes	D2R
T4700	15313-15324	NNS	denotes	antagonists
T4701	15325-15327	IN	denotes	in
T4702	15328-15335	NNS	denotes	rodents
T4703	15336-15344	RB	denotes	actually
T4690	15345-15350	VBZ	denotes	leads
T4704	15351-15353	IN	denotes	to
T4705	15354-15355	DT	denotes	a
T4707	15356-15364	JJ	denotes	striking
T4708	15365-15375	JJ	denotes	behavioral
T4706	15376-15385	NN	denotes	tolerance
T4709	15386-15388	IN	denotes	to
T4710	15389-15398	NN	denotes	catalepsy
T4711	15398-15399	.	denotes	.
T4712	15399-15475	sentence	denotes	These doses have been shown to occupy well over 80% of available D2Rs [29].
T4713	15400-15405	DT	denotes	These
T4714	15406-15411	NNS	denotes	doses
T4716	15412-15416	VBP	denotes	have
T4717	15417-15421	VBN	denotes	been
T4715	15422-15427	VBN	denotes	shown
T4718	15428-15430	TO	denotes	to
T4719	15431-15437	VB	denotes	occupy
T4720	15438-15442	RB	denotes	well
T4722	15443-15447	IN	denotes	over
T4721	15448-15450	CD	denotes	80
T4723	15450-15451	NN	denotes	%
T4724	15452-15454	IN	denotes	of
T4725	15455-15464	JJ	denotes	available
T4726	15465-15469	NNS	denotes	D2Rs
T4727	15470-15471	-LRB-	denotes	[
T4728	15471-15473	CD	denotes	29
T4729	15473-15474	-RRB-	denotes	]
T4730	15474-15475	.	denotes	.
T4731	15475-15723	sentence	denotes	Future experiments measuring acquisition of associative learning in rodents that received chronic administration of D2R antagonists and demonstrated behavioral tolerance to their motor disrupting effects would be a logical test of this hypothesis.
T4732	15476-15482	JJ	denotes	Future
T4733	15483-15494	NNS	denotes	experiments
T4735	15495-15504	VBG	denotes	measuring
T4736	15505-15516	NN	denotes	acquisition
T4737	15517-15519	IN	denotes	of
T4738	15520-15531	JJ	denotes	associative
T4739	15532-15540	NN	denotes	learning
T4740	15541-15543	IN	denotes	in
T4741	15544-15551	NNS	denotes	rodents
T4742	15552-15556	WDT	denotes	that
T4743	15557-15565	VBD	denotes	received
T4744	15566-15573	JJ	denotes	chronic
T4745	15574-15588	NN	denotes	administration
T4746	15589-15591	IN	denotes	of
T4747	15592-15595	NN	denotes	D2R
T4748	15596-15607	NNS	denotes	antagonists
T4749	15608-15611	CC	denotes	and
T4750	15612-15624	VBD	denotes	demonstrated
T4751	15625-15635	JJ	denotes	behavioral
T4752	15636-15645	NN	denotes	tolerance
T4753	15646-15648	IN	denotes	to
T4754	15649-15654	PRP$	denotes	their
T4756	15655-15660	NN	denotes	motor
T4757	15661-15671	VBG	denotes	disrupting
T4755	15672-15679	NNS	denotes	effects
T4758	15680-15685	MD	denotes	would
T4734	15686-15688	VB	denotes	be
T4759	15689-15690	DT	denotes	a
T4761	15691-15698	JJ	denotes	logical
T4760	15699-15703	NN	denotes	test
T4762	15704-15706	IN	denotes	of
T4763	15707-15711	DT	denotes	this
T4764	15712-15722	NN	denotes	hypothesis
T4765	15722-15723	.	denotes	.
T4766	15723-15932	sentence	denotes	However, the realization that multiple dopamine receptor subtypes would be concurrently targeted with the presently commercially available antagonists, such as D2Rs, D3Rs, and D4Rs would have to be rectified.
T4767	15724-15731	RB	denotes	However
T4769	15731-15733	,	denotes	,
T4770	15733-15736	DT	denotes	the
T4771	15737-15748	NN	denotes	realization
T4772	15749-15753	IN	denotes	that
T4774	15754-15762	JJ	denotes	multiple
T4776	15763-15771	NN	denotes	dopamine
T4777	15772-15780	NN	denotes	receptor
T4775	15781-15789	NNS	denotes	subtypes
T4778	15790-15795	MD	denotes	would
T4779	15796-15798	VB	denotes	be
T4780	15799-15811	RB	denotes	concurrently
T4773	15812-15820	VBN	denotes	targeted
T4781	15821-15825	IN	denotes	with
T4782	15826-15829	DT	denotes	the
T4784	15830-15839	RB	denotes	presently
T4786	15840-15852	RB	denotes	commercially
T4785	15853-15862	JJ	denotes	available
T4783	15863-15874	NNS	denotes	antagonists
T4787	15874-15876	,	denotes	,
T4788	15876-15880	JJ	denotes	such
T4789	15881-15883	IN	denotes	as
T4790	15884-15888	NNS	denotes	D2Rs
T4791	15888-15890	,	denotes	,
T4792	15890-15894	NNS	denotes	D3Rs
T4793	15894-15896	,	denotes	,
T4794	15896-15899	CC	denotes	and
T4795	15900-15904	NNS	denotes	D4Rs
T4796	15905-15910	MD	denotes	would
T4768	15911-15915	VB	denotes	have
T4797	15916-15918	TO	denotes	to
T4799	15919-15921	VB	denotes	be
T4798	15922-15931	VBN	denotes	rectified
T4800	15931-15932	.	denotes	.
T4801	15932-16146	sentence	denotes	We would argue that the most parsimonious approach at this time is to utilize mice that have been genetically altered such that they are lacking one or both functional alleles of the specific receptor of interest.
T4802	15933-15935	PRP	denotes	We
T4804	15936-15941	MD	denotes	would
T4803	15942-15947	VB	denotes	argue
T4805	15948-15952	IN	denotes	that
T4807	15953-15956	DT	denotes	the
T4809	15957-15961	RBS	denotes	most
T4810	15962-15974	JJ	denotes	parsimonious
T4808	15975-15983	NN	denotes	approach
T4811	15984-15986	IN	denotes	at
T4812	15987-15991	DT	denotes	this
T4813	15992-15996	NN	denotes	time
T4806	15997-15999	VBZ	denotes	is
T4814	16000-16002	TO	denotes	to
T4815	16003-16010	VB	denotes	utilize
T4816	16011-16015	NNS	denotes	mice
T4817	16016-16020	WDT	denotes	that
T4819	16021-16025	VBP	denotes	have
T4820	16026-16030	VBN	denotes	been
T4821	16031-16042	RB	denotes	genetically
T4818	16043-16050	VBN	denotes	altered
T4822	16051-16055	JJ	denotes	such
T4824	16056-16060	IN	denotes	that
T4825	16061-16065	PRP	denotes	they
T4826	16066-16069	VBP	denotes	are
T4823	16070-16077	VBG	denotes	lacking
T4827	16078-16081	CD	denotes	one
T4829	16082-16084	CC	denotes	or
T4830	16085-16089	DT	denotes	both
T4831	16090-16100	JJ	denotes	functional
T4828	16101-16108	NNS	denotes	alleles
T4832	16109-16111	IN	denotes	of
T4833	16112-16115	DT	denotes	the
T4835	16116-16124	JJ	denotes	specific
T4834	16125-16133	NN	denotes	receptor
T4836	16134-16136	IN	denotes	of
T4837	16137-16145	NN	denotes	interest
T4838	16145-16146	.	denotes	.
T4839	16146-16698	sentence	denotes	While they do have their limitations (e.g. developmental compensation and strain effects in mouse lines not backcrossed adequately to a parental strain for a minimum of 10 generations), use of our inbred (N20 generation) animals in the present study (where no differences in locomotor behavior were detected between D2R-/- and D2R+/+ mice; Figs. 1 &2) revealed a previously unappreciated role of D2R-mediated signaling in associative learning and attention that could not be measured with the currently available, acutely administered D2R antagonists.
T4840	16147-16152	IN	denotes	While
T4842	16153-16157	PRP	denotes	they
T4843	16158-16160	VBP	denotes	do
T4841	16161-16165	VB	denotes	have
T4845	16166-16171	PRP$	denotes	their
T4846	16172-16183	NNS	denotes	limitations
T4847	16184-16185	-LRB-	denotes	(
T4849	16185-16189	FW	denotes	e.g.
T4850	16190-16203	JJ	denotes	developmental
T4848	16204-16216	NN	denotes	compensation
T4851	16217-16220	CC	denotes	and
T4852	16221-16227	NN	denotes	strain
T4853	16228-16235	NNS	denotes	effects
T4854	16236-16238	IN	denotes	in
T4855	16239-16244	NN	denotes	mouse
T4856	16245-16250	NNS	denotes	lines
T4857	16251-16254	RB	denotes	not
T4858	16255-16266	VBN	denotes	backcrossed
T4859	16267-16277	RB	denotes	adequately
T4860	16278-16280	IN	denotes	to
T4861	16281-16282	DT	denotes	a
T4863	16283-16291	JJ	denotes	parental
T4862	16292-16298	NN	denotes	strain
T4864	16299-16302	IN	denotes	for
T4865	16303-16304	DT	denotes	a
T4866	16305-16312	NN	denotes	minimum
T4867	16313-16315	IN	denotes	of
T4868	16316-16318	CD	denotes	10
T4869	16319-16330	NNS	denotes	generations
T4870	16330-16331	-RRB-	denotes	)
T4871	16331-16333	,	denotes	,
T4872	16333-16336	NN	denotes	use
T4873	16337-16339	IN	denotes	of
T4874	16340-16343	PRP$	denotes	our
T4876	16344-16350	JJ	denotes	inbred
T4877	16351-16352	-LRB-	denotes	(
T4879	16352-16355	NN	denotes	N20
T4878	16356-16366	NN	denotes	generation
T4880	16366-16367	-RRB-	denotes	)
T4875	16368-16375	NNS	denotes	animals
T4881	16376-16378	IN	denotes	in
T4882	16379-16382	DT	denotes	the
T4884	16383-16390	JJ	denotes	present
T4883	16391-16396	NN	denotes	study
T4885	16397-16398	-LRB-	denotes	(
T4886	16398-16403	WRB	denotes	where
T4888	16404-16406	DT	denotes	no
T4889	16407-16418	NNS	denotes	differences
T4890	16419-16421	IN	denotes	in
T4891	16422-16431	NN	denotes	locomotor
T4892	16432-16440	NN	denotes	behavior
T4893	16441-16445	VBD	denotes	were
T4887	16446-16454	VBN	denotes	detected
T4894	16455-16462	IN	denotes	between
T4895	16463-16466	NN	denotes	D2R
T4897	16466-16467	SYM	denotes	-
T4898	16467-16468	HYPH	denotes	/
T4899	16468-16469	SYM	denotes	-
T4900	16470-16473	CC	denotes	and
T4901	16474-16477	NN	denotes	D2R
T4902	16477-16478	SYM	denotes	+
T4903	16478-16479	HYPH	denotes	/
T4904	16479-16480	SYM	denotes	+
T4896	16481-16485	NNS	denotes	mice
T4905	16485-16486	:	denotes	;
T4906	16487-16492	NNS	denotes	Figs.
T4907	16493-16494	CD	denotes	1
T4908	16495-16496	CC	denotes	&
T4909	16496-16497	CD	denotes	2
T4910	16497-16498	-RRB-	denotes	)
T4844	16499-16507	VBD	denotes	revealed
T4911	16508-16509	DT	denotes	a
T4913	16510-16520	RB	denotes	previously
T4914	16521-16534	JJ	denotes	unappreciated
T4912	16535-16539	NN	denotes	role
T4915	16540-16542	IN	denotes	of
T4916	16543-16546	NN	denotes	D2R
T4918	16546-16547	HYPH	denotes	-
T4917	16547-16555	VBN	denotes	mediated
T4919	16556-16565	NN	denotes	signaling
T4920	16566-16568	IN	denotes	in
T4921	16569-16580	JJ	denotes	associative
T4922	16581-16589	NN	denotes	learning
T4923	16590-16593	CC	denotes	and
T4924	16594-16603	NN	denotes	attention
T4925	16604-16608	WDT	denotes	that
T4927	16609-16614	MD	denotes	could
T4928	16615-16618	RB	denotes	not
T4929	16619-16621	VB	denotes	be
T4926	16622-16630	VBN	denotes	measured
T4930	16631-16635	IN	denotes	with
T4931	16636-16639	DT	denotes	the
T4933	16640-16649	RB	denotes	currently
T4934	16650-16659	JJ	denotes	available
T4935	16659-16661	,	denotes	,
T4936	16661-16668	RB	denotes	acutely
T4937	16669-16681	VBN	denotes	administered
T4938	16682-16685	NN	denotes	D2R
T4932	16686-16697	NNS	denotes	antagonists
T4939	16697-16698	.	denotes	.
T4940	16698-16858	sentence	denotes	A cursory analysis of our data might suggest to some that the genetic manipulation of the drd2 locus conferred a gross olfactory impairment to the D2R-/- mice.
T4941	16699-16700	DT	denotes	A
T4943	16701-16708	JJ	denotes	cursory
T4942	16709-16717	NN	denotes	analysis
T4945	16718-16720	IN	denotes	of
T4946	16721-16724	PRP$	denotes	our
T4947	16725-16729	NNS	denotes	data
T4948	16730-16735	MD	denotes	might
T4944	16736-16743	VB	denotes	suggest
T4949	16744-16746	IN	denotes	to
T4950	16747-16751	DT	denotes	some
T4951	16752-16756	IN	denotes	that
T4953	16757-16760	DT	denotes	the
T4955	16761-16768	JJ	denotes	genetic
T4954	16769-16781	NN	denotes	manipulation
T4956	16782-16784	IN	denotes	of
T4957	16785-16788	DT	denotes	the
T4959	16789-16793	NN	denotes	drd2
T4958	16794-16799	NN	denotes	locus
T4952	16800-16809	VBD	denotes	conferred
T4960	16810-16811	DT	denotes	a
T4962	16812-16817	JJ	denotes	gross
T4963	16818-16827	JJ	denotes	olfactory
T4961	16828-16838	NN	denotes	impairment
T4964	16839-16841	IN	denotes	to
T4965	16842-16845	DT	denotes	the
T4967	16846-16849	NN	denotes	D2R
T4968	16849-16850	SYM	denotes	-
T4969	16850-16851	HYPH	denotes	/
T4970	16851-16852	SYM	denotes	-
T4966	16853-16857	NNS	denotes	mice
T4971	16857-16858	.	denotes	.
T4972	16858-17035	sentence	denotes	Rather, we argue that this is not likely because the D2R-/- mice did learn to retrieve the food pellets from the dishes and eventually learned to accurately discriminate odors.
T4973	16859-16865	RB	denotes	Rather
T4975	16865-16867	,	denotes	,
T4976	16867-16869	PRP	denotes	we
T4974	16870-16875	VBP	denotes	argue
T4977	16876-16880	IN	denotes	that
T4979	16881-16885	DT	denotes	this
T4978	16886-16888	VBZ	denotes	is
T4980	16889-16892	RB	denotes	not
T4981	16893-16899	JJ	denotes	likely
T4982	16900-16907	IN	denotes	because
T4984	16908-16911	DT	denotes	the
T4986	16912-16915	NN	denotes	D2R
T4987	16915-16916	SYM	denotes	-
T4988	16916-16917	HYPH	denotes	/
T4989	16917-16918	SYM	denotes	-
T4985	16919-16923	NNS	denotes	mice
T4990	16924-16927	VBD	denotes	did
T4983	16928-16933	VB	denotes	learn
T4991	16934-16936	TO	denotes	to
T4992	16937-16945	VB	denotes	retrieve
T4993	16946-16949	DT	denotes	the
T4995	16950-16954	NN	denotes	food
T4994	16955-16962	NNS	denotes	pellets
T4996	16963-16967	IN	denotes	from
T4997	16968-16971	DT	denotes	the
T4998	16972-16978	NNS	denotes	dishes
T4999	16979-16982	CC	denotes	and
T5000	16983-16993	RB	denotes	eventually
T5001	16994-17001	VBD	denotes	learned
T5002	17002-17004	TO	denotes	to
T5004	17005-17015	RB	denotes	accurately
T5003	17016-17028	VB	denotes	discriminate
T5005	17029-17034	NNS	denotes	odors
T5006	17034-17035	.	denotes	.
T5007	17035-17267	sentence	denotes	Recent electrophysiological data demonstrate that dopamine D2R's are located on glutamatergic terminal axons of olfactory nerves and depress excitatory input of the olfactory nerve to the mitral cells of the olfactory bulb [30,31].
T5008	17036-17042	JJ	denotes	Recent
T5010	17043-17063	JJ	denotes	electrophysiological
T5009	17064-17068	NNS	denotes	data
T5011	17069-17080	VBP	denotes	demonstrate
T5012	17081-17085	IN	denotes	that
T5014	17086-17094	NN	denotes	dopamine
T5015	17095-17100	NNS	denotes	D2R's
T5016	17101-17104	VBP	denotes	are
T5013	17105-17112	VBN	denotes	located
T5017	17113-17115	IN	denotes	on
T5018	17116-17129	JJ	denotes	glutamatergic
T5020	17130-17138	JJ	denotes	terminal
T5019	17139-17144	NNS	denotes	axons
T5021	17145-17147	IN	denotes	of
T5022	17148-17157	JJ	denotes	olfactory
T5023	17158-17164	NNS	denotes	nerves
T5024	17165-17168	CC	denotes	and
T5025	17169-17176	VB	denotes	depress
T5026	17177-17187	JJ	denotes	excitatory
T5027	17188-17193	NN	denotes	input
T5028	17194-17196	IN	denotes	of
T5029	17197-17200	DT	denotes	the
T5031	17201-17210	JJ	denotes	olfactory
T5030	17211-17216	NN	denotes	nerve
T5032	17217-17219	IN	denotes	to
T5033	17220-17223	DT	denotes	the
T5035	17224-17230	JJ	denotes	mitral
T5034	17231-17236	NNS	denotes	cells
T5036	17237-17239	IN	denotes	of
T5037	17240-17243	DT	denotes	the
T5039	17244-17253	JJ	denotes	olfactory
T5038	17254-17258	NN	denotes	bulb
T5040	17259-17260	-LRB-	denotes	[
T5042	17260-17262	CD	denotes	30
T5043	17262-17263	,	denotes	,
T5041	17263-17265	CD	denotes	31
T5044	17265-17266	-RRB-	denotes	]
T5045	17266-17267	.	denotes	.
T5046	17267-17591	sentence	denotes	Consequently, our data, and data from other studies, suggest that the complete lack of D2Rs in the olfactory bulb does not prevent transduction of olfactory stimuli; rather it affects the ability to habituate, or tune, olfactory nerve activity associated with repeatedly encountered concentrations of chemical stimuli [32].
T5047	17268-17280	RB	denotes	Consequently
T5049	17280-17282	,	denotes	,
T5050	17282-17285	PRP$	denotes	our
T5051	17286-17290	NNS	denotes	data
T5052	17290-17292	,	denotes	,
T5053	17292-17295	CC	denotes	and
T5054	17296-17300	NNS	denotes	data
T5055	17301-17305	IN	denotes	from
T5056	17306-17311	JJ	denotes	other
T5057	17312-17319	NNS	denotes	studies
T5058	17319-17321	,	denotes	,
T5048	17321-17328	VBP	denotes	suggest
T5060	17329-17333	IN	denotes	that
T5062	17334-17337	DT	denotes	the
T5064	17338-17346	JJ	denotes	complete
T5063	17347-17351	NN	denotes	lack
T5065	17352-17354	IN	denotes	of
T5066	17355-17359	NNS	denotes	D2Rs
T5067	17360-17362	IN	denotes	in
T5068	17363-17366	DT	denotes	the
T5070	17367-17376	JJ	denotes	olfactory
T5069	17377-17381	NN	denotes	bulb
T5071	17382-17386	VBZ	denotes	does
T5072	17387-17390	RB	denotes	not
T5061	17391-17398	VB	denotes	prevent
T5073	17399-17411	NN	denotes	transduction
T5074	17412-17414	IN	denotes	of
T5075	17415-17424	JJ	denotes	olfactory
T5076	17425-17432	NNS	denotes	stimuli
T5077	17432-17433	:	denotes	;
T5078	17434-17440	RB	denotes	rather
T5079	17441-17443	PRP	denotes	it
T5059	17444-17451	VBZ	denotes	affects
T5080	17452-17455	DT	denotes	the
T5081	17456-17463	NN	denotes	ability
T5082	17464-17466	TO	denotes	to
T5083	17467-17476	VB	denotes	habituate
T5084	17476-17478	,	denotes	,
T5085	17478-17480	CC	denotes	or
T5086	17481-17485	VB	denotes	tune
T5087	17485-17487	,	denotes	,
T5088	17487-17496	JJ	denotes	olfactory
T5089	17497-17502	NN	denotes	nerve
T5090	17503-17511	NN	denotes	activity
T5091	17512-17522	VBN	denotes	associated
T5092	17523-17527	IN	denotes	with
T5093	17528-17538	RB	denotes	repeatedly
T5094	17539-17550	VBN	denotes	encountered
T5095	17551-17565	NNS	denotes	concentrations
T5096	17566-17568	IN	denotes	of
T5097	17569-17577	JJ	denotes	chemical
T5098	17578-17585	NNS	denotes	stimuli
T5099	17586-17587	-LRB-	denotes	[
T5100	17587-17589	CD	denotes	32
T5101	17589-17590	-RRB-	denotes	]
T5102	17590-17591	.	denotes	.
T5103	17591-17756	sentence	denotes	The performance of D2R-/- mice during reversal learning is deficient revealing a role for dopamine D2R-mediated signaling in tasks requiring behavioral flexibility
T5104	17593-17596	DT	denotes	The
T5105	17597-17608	NN	denotes	performance
T5107	17609-17611	IN	denotes	of
T5108	17612-17615	NN	denotes	D2R
T5110	17615-17616	SYM	denotes	-
T5111	17616-17617	HYPH	denotes	/
T5112	17617-17618	SYM	denotes	-
T5109	17619-17623	NNS	denotes	mice
T5113	17624-17630	IN	denotes	during
T5114	17631-17639	NN	denotes	reversal
T5115	17640-17648	NN	denotes	learning
T5106	17649-17651	VBZ	denotes	is
T5116	17652-17661	JJ	denotes	deficient
T5117	17662-17671	VBG	denotes	revealing
T5118	17672-17673	DT	denotes	a
T5119	17674-17678	NN	denotes	role
T5120	17679-17682	IN	denotes	for
T5121	17683-17691	NN	denotes	dopamine
T5122	17692-17695	NN	denotes	D2R
T5124	17695-17696	HYPH	denotes	-
T5123	17696-17704	VBN	denotes	mediated
T5125	17705-17714	NN	denotes	signaling
T5126	17715-17717	IN	denotes	in
T5127	17718-17723	NNS	denotes	tasks
T5128	17724-17733	VBG	denotes	requiring
T5129	17734-17744	JJ	denotes	behavioral
T5130	17745-17756	NN	denotes	flexibility
T5131	17756-17991	sentence	denotes	Perseverative behavioral patterns characterized the D2R-/- mice relative to D2R+/+ mice during reversal learning sessions (Figure 4), manifested during early reversal trials (Figure 6) and persisted across several sessions (Figure 7).
T5132	17757-17770	JJ	denotes	Perseverative
T5134	17771-17781	JJ	denotes	behavioral
T5133	17782-17790	NNS	denotes	patterns
T5135	17791-17804	VBD	denotes	characterized
T5136	17805-17808	DT	denotes	the
T5138	17809-17812	NN	denotes	D2R
T5139	17812-17813	SYM	denotes	-
T5140	17813-17814	HYPH	denotes	/
T5141	17814-17815	SYM	denotes	-
T5137	17816-17820	NNS	denotes	mice
T5142	17821-17829	JJ	denotes	relative
T5143	17830-17832	IN	denotes	to
T5144	17833-17836	NN	denotes	D2R
T5146	17836-17837	SYM	denotes	+
T5147	17837-17838	HYPH	denotes	/
T5148	17838-17839	SYM	denotes	+
T5145	17840-17844	NNS	denotes	mice
T5149	17845-17851	IN	denotes	during
T5150	17852-17860	NN	denotes	reversal
T5152	17861-17869	NN	denotes	learning
T5151	17870-17878	NNS	denotes	sessions
T5153	17879-17880	-LRB-	denotes	(
T5154	17880-17886	NN	denotes	Figure
T5155	17887-17888	CD	denotes	4
T5156	17888-17889	-RRB-	denotes	)
T5157	17889-17891	,	denotes	,
T5158	17891-17901	VBD	denotes	manifested
T5159	17902-17908	IN	denotes	during
T5160	17909-17914	JJ	denotes	early
T5162	17915-17923	NN	denotes	reversal
T5161	17924-17930	NNS	denotes	trials
T5163	17931-17932	-LRB-	denotes	(
T5164	17932-17938	NN	denotes	Figure
T5165	17939-17940	CD	denotes	6
T5166	17940-17941	-RRB-	denotes	)
T5167	17942-17945	CC	denotes	and
T5168	17946-17955	VBD	denotes	persisted
T5169	17956-17962	IN	denotes	across
T5170	17963-17970	JJ	denotes	several
T5171	17971-17979	NNS	denotes	sessions
T5172	17980-17981	-LRB-	denotes	(
T5173	17981-17987	NN	denotes	Figure
T5174	17988-17989	CD	denotes	7
T5175	17989-17990	-RRB-	denotes	)
T5176	17990-17991	.	denotes	.
T5177	17991-18297	sentence	denotes	These findings are significant because D2R-/- mice respond to food reinforcers and ultimately form and maintain odor-driven S+/S- relationships (a putative D1R-mediated behavior [6]) just as D2R+/+ mice (both groups achieved ≥ 80% discrimination accuracy, the dopamine D1Rs in our mice were not targeted).
T5178	17992-17997	DT	denotes	These
T5179	17998-18006	NNS	denotes	findings
T5180	18007-18010	VBP	denotes	are
T5181	18011-18022	JJ	denotes	significant
T5182	18023-18030	IN	denotes	because
T5184	18031-18034	NN	denotes	D2R
T5186	18034-18035	SYM	denotes	-
T5187	18035-18036	HYPH	denotes	/
T5188	18036-18037	SYM	denotes	-
T5185	18038-18042	NNS	denotes	mice
T5183	18043-18050	VBP	denotes	respond
T5189	18051-18053	IN	denotes	to
T5190	18054-18058	NN	denotes	food
T5191	18059-18070	NNS	denotes	reinforcers
T5192	18071-18074	CC	denotes	and
T5193	18075-18085	RB	denotes	ultimately
T5194	18086-18090	VBP	denotes	form
T5195	18091-18094	CC	denotes	and
T5196	18095-18103	VBP	denotes	maintain
T5197	18104-18108	NN	denotes	odor
T5199	18108-18109	HYPH	denotes	-
T5198	18109-18115	VBN	denotes	driven
T5201	18116-18117	NN	denotes	S
T5202	18117-18118	SYM	denotes	+
T5203	18118-18119	HYPH	denotes	/
T5204	18119-18120	NN	denotes	S
T5205	18120-18121	SYM	denotes	-
T5200	18122-18135	NNS	denotes	relationships
T5206	18136-18137	-LRB-	denotes	(
T5208	18137-18138	DT	denotes	a
T5209	18139-18147	JJ	denotes	putative
T5210	18148-18151	NN	denotes	D1R
T5212	18151-18152	HYPH	denotes	-
T5211	18152-18160	VBN	denotes	mediated
T5207	18161-18169	NN	denotes	behavior
T5213	18170-18171	-LRB-	denotes	[
T5214	18171-18172	CD	denotes	6
T5215	18172-18173	-RRB-	denotes	]
T5216	18173-18174	-RRB-	denotes	)
T5217	18175-18179	RB	denotes	just
T5218	18180-18182	IN	denotes	as
T5219	18183-18186	NN	denotes	D2R
T5221	18186-18187	SYM	denotes	+
T5222	18187-18188	HYPH	denotes	/
T5223	18188-18189	SYM	denotes	+
T5220	18190-18194	NNS	denotes	mice
T5224	18195-18196	-LRB-	denotes	(
T5226	18196-18200	DT	denotes	both
T5227	18201-18207	NNS	denotes	groups
T5228	18208-18216	VBD	denotes	achieved
T5229	18217-18218	SYM	denotes	≥
T5230	18219-18221	CD	denotes	80
T5231	18221-18222	NN	denotes	%
T5233	18223-18237	NN	denotes	discrimination
T5232	18238-18246	NN	denotes	accuracy
T5234	18246-18248	,	denotes	,
T5235	18248-18251	DT	denotes	the
T5237	18252-18260	NN	denotes	dopamine
T5236	18261-18265	NNS	denotes	D1Rs
T5238	18266-18268	IN	denotes	in
T5239	18269-18272	PRP$	denotes	our
T5240	18273-18277	NNS	denotes	mice
T5241	18278-18282	VBD	denotes	were
T5242	18283-18286	RB	denotes	not
T5225	18287-18295	VBN	denotes	targeted
T5243	18295-18296	-RRB-	denotes	)
T5244	18296-18297	.	denotes	.
T5245	18297-18497	sentence	denotes	A future extension of this study would be to test performance over a fixed number of trials and determine patterns of error rates during acquisition of the discrimination and reversal learning tasks.
T5246	18298-18299	DT	denotes	A
T5248	18300-18306	JJ	denotes	future
T5247	18307-18316	NN	denotes	extension
T5250	18317-18319	IN	denotes	of
T5251	18320-18324	DT	denotes	this
T5252	18325-18330	NN	denotes	study
T5253	18331-18336	MD	denotes	would
T5249	18337-18339	VB	denotes	be
T5254	18340-18342	TO	denotes	to
T5255	18343-18347	VB	denotes	test
T5256	18348-18359	NN	denotes	performance
T5257	18360-18364	IN	denotes	over
T5258	18365-18366	DT	denotes	a
T5260	18367-18372	VBN	denotes	fixed
T5259	18373-18379	NN	denotes	number
T5261	18380-18382	IN	denotes	of
T5262	18383-18389	NNS	denotes	trials
T5263	18390-18393	CC	denotes	and
T5264	18394-18403	VB	denotes	determine
T5265	18404-18412	NNS	denotes	patterns
T5266	18413-18415	IN	denotes	of
T5267	18416-18421	NN	denotes	error
T5268	18422-18427	NNS	denotes	rates
T5269	18428-18434	IN	denotes	during
T5270	18435-18446	NN	denotes	acquisition
T5271	18447-18449	IN	denotes	of
T5272	18450-18453	DT	denotes	the
T5274	18454-18468	NN	denotes	discrimination
T5275	18469-18472	CC	denotes	and
T5276	18473-18481	NN	denotes	reversal
T5277	18482-18490	NN	denotes	learning
T5273	18491-18496	NNS	denotes	tasks
T5278	18496-18497	.	denotes	.
T5279	18497-18752	sentence	denotes	This manipulation would control the number of errors based on trials performed to determine if the apparent difference in absolute number of errors demonstrated by the mutant mice (the putative performance deficit) is simply a reflection of extra trials.
T5280	18498-18502	DT	denotes	This
T5281	18503-18515	NN	denotes	manipulation
T5283	18516-18521	MD	denotes	would
T5282	18522-18529	VB	denotes	control
T5284	18530-18533	DT	denotes	the
T5285	18534-18540	NN	denotes	number
T5286	18541-18543	IN	denotes	of
T5287	18544-18550	NNS	denotes	errors
T5288	18551-18556	VBN	denotes	based
T5289	18557-18559	IN	denotes	on
T5290	18560-18566	NNS	denotes	trials
T5291	18567-18576	VBN	denotes	performed
T5292	18577-18579	TO	denotes	to
T5293	18580-18589	VB	denotes	determine
T5294	18590-18592	IN	denotes	if
T5296	18593-18596	DT	denotes	the
T5298	18597-18605	JJ	denotes	apparent
T5297	18606-18616	NN	denotes	difference
T5299	18617-18619	IN	denotes	in
T5300	18620-18628	JJ	denotes	absolute
T5301	18629-18635	NN	denotes	number
T5302	18636-18638	IN	denotes	of
T5303	18639-18645	NNS	denotes	errors
T5304	18646-18658	VBN	denotes	demonstrated
T5305	18659-18661	IN	denotes	by
T5306	18662-18665	DT	denotes	the
T5308	18666-18672	JJ	denotes	mutant
T5307	18673-18677	NNS	denotes	mice
T5309	18678-18679	-LRB-	denotes	(
T5311	18679-18682	DT	denotes	the
T5312	18683-18691	JJ	denotes	putative
T5313	18692-18703	NN	denotes	performance
T5310	18704-18711	NN	denotes	deficit
T5314	18711-18712	-RRB-	denotes	)
T5295	18713-18715	VBZ	denotes	is
T5315	18716-18722	RB	denotes	simply
T5317	18723-18724	DT	denotes	a
T5316	18725-18735	NN	denotes	reflection
T5318	18736-18738	IN	denotes	of
T5319	18739-18744	JJ	denotes	extra
T5320	18745-18751	NNS	denotes	trials
T5321	18751-18752	.	denotes	.
T5322	18752-19116	sentence	denotes	Nonetheless, the inability of D2R-/- mice to disengage from previously established S+/S- contingencies (responding to a discriminative stimulus; Fig. 4) strongly argues that mesolimbic dopamine, and in particular dopamine D2R-mediated signaling, modulates the process of alerting the subject that familiar contingencies are now associated unexpected consequences.
T5323	18753-18764	RB	denotes	Nonetheless
T5325	18764-18766	,	denotes	,
T5326	18766-18769	DT	denotes	the
T5327	18770-18779	NN	denotes	inability
T5328	18780-18782	IN	denotes	of
T5329	18783-18786	NN	denotes	D2R
T5331	18786-18787	SYM	denotes	-
T5332	18787-18788	HYPH	denotes	/
T5333	18788-18789	SYM	denotes	-
T5330	18790-18794	NNS	denotes	mice
T5334	18795-18797	TO	denotes	to
T5335	18798-18807	VB	denotes	disengage
T5336	18808-18812	IN	denotes	from
T5337	18813-18823	RB	denotes	previously
T5338	18824-18835	VBN	denotes	established
T5340	18836-18837	NN	denotes	S
T5341	18837-18838	SYM	denotes	+
T5342	18838-18839	HYPH	denotes	/
T5343	18839-18840	NN	denotes	S
T5344	18840-18841	HYPH	denotes	-
T5339	18842-18855	NNS	denotes	contingencies
T5345	18856-18857	-LRB-	denotes	(
T5347	18857-18867	VBG	denotes	responding
T5348	18868-18870	IN	denotes	to
T5349	18871-18872	DT	denotes	a
T5351	18873-18887	JJ	denotes	discriminative
T5350	18888-18896	NN	denotes	stimulus
T5352	18896-18897	:	denotes	;
T5346	18898-18902	NN	denotes	Fig.
T5353	18903-18904	CD	denotes	4
T5354	18904-18905	-RRB-	denotes	)
T5355	18906-18914	RB	denotes	strongly
T5324	18915-18921	VBZ	denotes	argues
T5356	18922-18926	IN	denotes	that
T5358	18927-18937	JJ	denotes	mesolimbic
T5359	18938-18946	NN	denotes	dopamine
T5360	18946-18948	,	denotes	,
T5361	18948-18951	CC	denotes	and
T5362	18952-18954	IN	denotes	in
T5364	18955-18965	JJ	denotes	particular
T5365	18966-18974	NN	denotes	dopamine
T5366	18975-18978	NN	denotes	D2R
T5368	18978-18979	HYPH	denotes	-
T5367	18979-18987	VBN	denotes	mediated
T5363	18988-18997	NN	denotes	signaling
T5369	18997-18999	,	denotes	,
T5357	18999-19008	VBZ	denotes	modulates
T5370	19009-19012	DT	denotes	the
T5371	19013-19020	NN	denotes	process
T5372	19021-19023	IN	denotes	of
T5373	19024-19032	VBG	denotes	alerting
T5374	19033-19036	DT	denotes	the
T5375	19037-19044	NN	denotes	subject
T5376	19045-19049	IN	denotes	that
T5378	19050-19058	JJ	denotes	familiar
T5379	19059-19072	NNS	denotes	contingencies
T5380	19073-19076	VBP	denotes	are
T5381	19077-19080	RB	denotes	now
T5377	19081-19091	VBN	denotes	associated
T5382	19092-19102	JJ	denotes	unexpected
T5383	19103-19115	NNS	denotes	consequences
T5384	19115-19116	.	denotes	.
T5385	19116-19273	sentence	denotes	Schultz and colleagues have demonstrated that dopamine cells display consistent tonic firing patterns during maintenance of associative learning tasks [33].
T5386	19117-19124	NNP	denotes	Schultz
T5388	19125-19128	CC	denotes	and
T5389	19129-19139	NNS	denotes	colleagues
T5390	19140-19144	VBP	denotes	have
T5387	19145-19157	VBN	denotes	demonstrated
T5391	19158-19162	IN	denotes	that
T5393	19163-19171	NN	denotes	dopamine
T5394	19172-19177	NNS	denotes	cells
T5392	19178-19185	VBP	denotes	display
T5395	19186-19196	JJ	denotes	consistent
T5397	19197-19202	JJ	denotes	tonic
T5398	19203-19209	NN	denotes	firing
T5396	19210-19218	NNS	denotes	patterns
T5399	19219-19225	IN	denotes	during
T5400	19226-19237	NN	denotes	maintenance
T5401	19238-19240	IN	denotes	of
T5402	19241-19252	JJ	denotes	associative
T5403	19253-19261	NN	denotes	learning
T5404	19262-19267	NNS	denotes	tasks
T5405	19268-19269	-LRB-	denotes	[
T5406	19269-19271	CD	denotes	33
T5407	19271-19272	-RRB-	denotes	]
T5408	19272-19273	.	denotes	.
T5409	19273-19425	sentence	denotes	However, phasic burst activity of dopaminergic cells occurs when discrepancies between predicted and actual reinforcement contingencies transpire [14].
T5410	19274-19281	RB	denotes	However
T5412	19281-19283	,	denotes	,
T5413	19283-19289	JJ	denotes	phasic
T5415	19290-19295	NN	denotes	burst
T5414	19296-19304	NN	denotes	activity
T5416	19305-19307	IN	denotes	of
T5417	19308-19320	JJ	denotes	dopaminergic
T5418	19321-19326	NNS	denotes	cells
T5411	19327-19333	VBZ	denotes	occurs
T5419	19334-19338	WRB	denotes	when
T5421	19339-19352	NNS	denotes	discrepancies
T5422	19353-19360	IN	denotes	between
T5423	19361-19370	JJ	denotes	predicted
T5425	19371-19374	CC	denotes	and
T5426	19375-19381	JJ	denotes	actual
T5427	19382-19395	NN	denotes	reinforcement
T5424	19396-19409	NNS	denotes	contingencies
T5420	19410-19419	VBP	denotes	transpire
T5428	19420-19421	-LRB-	denotes	[
T5429	19421-19423	CD	denotes	14
T5430	19423-19424	-RRB-	denotes	]
T5431	19424-19425	.	denotes	.
T5432	19425-19562	sentence	denotes	This robust increase of dopaminergic cell activation in response to unpredicted outcomes has been referred to as an "error" signal [14].
T5433	19426-19430	DT	denotes	This
T5435	19431-19437	JJ	denotes	robust
T5434	19438-19446	NN	denotes	increase
T5437	19447-19449	IN	denotes	of
T5438	19450-19462	JJ	denotes	dopaminergic
T5440	19463-19467	NN	denotes	cell
T5439	19468-19478	NN	denotes	activation
T5441	19479-19481	IN	denotes	in
T5442	19482-19490	NN	denotes	response
T5443	19491-19493	IN	denotes	to
T5444	19494-19505	JJ	denotes	unpredicted
T5445	19506-19514	NNS	denotes	outcomes
T5446	19515-19518	VBZ	denotes	has
T5447	19519-19523	VBN	denotes	been
T5436	19524-19532	VBN	denotes	referred
T5448	19533-19535	IN	denotes	to
T5449	19536-19538	IN	denotes	as
T5450	19539-19541	DT	denotes	an
T5452	19542-19543	``	denotes	"
T5453	19543-19548	NN	denotes	error
T5454	19548-19549	''	denotes	"
T5451	19550-19556	NN	denotes	signal
T5455	19557-19558	-LRB-	denotes	[
T5456	19558-19560	CD	denotes	14
T5457	19560-19561	-RRB-	denotes	]
T5458	19561-19562	.	denotes	.
T5459	19562-19637	sentence	denotes	To date, the molecular basis of this error signal has not been identified.
T5460	19563-19565	IN	denotes	To
T5462	19566-19570	NN	denotes	date
T5463	19570-19572	,	denotes	,
T5464	19572-19575	DT	denotes	the
T5466	19576-19585	JJ	denotes	molecular
T5465	19586-19591	NN	denotes	basis
T5467	19592-19594	IN	denotes	of
T5468	19595-19599	DT	denotes	this
T5470	19600-19605	NN	denotes	error
T5469	19606-19612	NN	denotes	signal
T5471	19613-19616	VBZ	denotes	has
T5472	19617-19620	RB	denotes	not
T5473	19621-19625	VBN	denotes	been
T5461	19626-19636	VBN	denotes	identified
T5474	19636-19637	.	denotes	.
T5475	19637-19824	sentence	denotes	The inability of the D2R-/- mice to desist responding to a previously reinforced stimulus suggests that the dopamine D2R might in fact be the focal point of this error-signaling cascade.
T5476	19638-19641	DT	denotes	The
T5477	19642-19651	NN	denotes	inability
T5479	19652-19654	IN	denotes	of
T5480	19655-19658	DT	denotes	the
T5482	19659-19662	NN	denotes	D2R
T5483	19662-19663	SYM	denotes	-
T5484	19663-19664	HYPH	denotes	/
T5485	19664-19665	SYM	denotes	-
T5481	19666-19670	NNS	denotes	mice
T5486	19671-19673	TO	denotes	to
T5487	19674-19680	VB	denotes	desist
T5488	19681-19691	VBG	denotes	responding
T5489	19692-19694	IN	denotes	to
T5490	19695-19696	DT	denotes	a
T5492	19697-19707	RB	denotes	previously
T5493	19708-19718	VBN	denotes	reinforced
T5491	19719-19727	NN	denotes	stimulus
T5478	19728-19736	VBZ	denotes	suggests
T5494	19737-19741	IN	denotes	that
T5496	19742-19745	DT	denotes	the
T5498	19746-19754	NN	denotes	dopamine
T5497	19755-19758	NN	denotes	D2R
T5499	19759-19764	MD	denotes	might
T5500	19765-19767	IN	denotes	in
T5501	19768-19772	NN	denotes	fact
T5495	19773-19775	VB	denotes	be
T5502	19776-19779	DT	denotes	the
T5504	19780-19785	JJ	denotes	focal
T5503	19786-19791	NN	denotes	point
T5505	19792-19794	IN	denotes	of
T5506	19795-19799	DT	denotes	this
T5508	19800-19805	NN	denotes	error
T5510	19805-19806	HYPH	denotes	-
T5509	19806-19815	VBG	denotes	signaling
T5507	19816-19823	NN	denotes	cascade
T5511	19823-19824	.	denotes	.
T5512	19824-19967	sentence	denotes	Electrophysiological data further support the hypothesis that signaling mediated by dopamine D2Rs tunes D1R-mediated mesocorticolimbic output.
T5513	19825-19845	JJ	denotes	Electrophysiological
T5514	19846-19850	NNS	denotes	data
T5516	19851-19858	RB	denotes	further
T5515	19859-19866	VBP	denotes	support
T5517	19867-19870	DT	denotes	the
T5518	19871-19881	NN	denotes	hypothesis
T5519	19882-19886	IN	denotes	that
T5521	19887-19896	NN	denotes	signaling
T5522	19897-19905	VBN	denotes	mediated
T5523	19906-19908	IN	denotes	by
T5524	19909-19917	NN	denotes	dopamine
T5525	19918-19922	NNS	denotes	D2Rs
T5520	19923-19928	VBZ	denotes	tunes
T5526	19929-19932	NN	denotes	D1R
T5528	19932-19933	HYPH	denotes	-
T5527	19933-19941	VBN	denotes	mediated
T5530	19942-19959	JJ	denotes	mesocorticolimbic
T5529	19960-19966	NN	denotes	output
T5531	19966-19967	.	denotes	.
T5532	19967-20166	sentence	denotes	Calabresi et al. [34] demonstrated that tetanic stimulation of dorsal striatum slices prepared from D2R-/- mice is associated with enhanced EPSP and as a result increased striatal synaptic efficacy.
T5533	19968-19977	NNP	denotes	Calabresi
T5535	19978-19980	FW	denotes	et
T5536	19981-19984	FW	denotes	al.
T5537	19985-19986	-LRB-	denotes	[
T5538	19986-19988	CD	denotes	34
T5539	19988-19989	-RRB-	denotes	]
T5534	19990-20002	VBD	denotes	demonstrated
T5540	20003-20007	IN	denotes	that
T5542	20008-20015	JJ	denotes	tetanic
T5543	20016-20027	NN	denotes	stimulation
T5544	20028-20030	IN	denotes	of
T5545	20031-20037	JJ	denotes	dorsal
T5547	20038-20046	NN	denotes	striatum
T5546	20047-20053	NNS	denotes	slices
T5548	20054-20062	VBN	denotes	prepared
T5549	20063-20067	IN	denotes	from
T5550	20068-20071	NN	denotes	D2R
T5552	20071-20072	SYM	denotes	-
T5553	20072-20073	HYPH	denotes	/
T5554	20073-20074	SYM	denotes	-
T5551	20075-20079	NNS	denotes	mice
T5555	20080-20082	VBZ	denotes	is
T5541	20083-20093	VBN	denotes	associated
T5556	20094-20098	IN	denotes	with
T5557	20099-20107	VBN	denotes	enhanced
T5558	20108-20112	NN	denotes	EPSP
T5559	20113-20116	CC	denotes	and
T5560	20117-20119	IN	denotes	as
T5562	20120-20121	DT	denotes	a
T5563	20122-20128	NN	denotes	result
T5564	20129-20138	VBN	denotes	increased
T5565	20139-20147	JJ	denotes	striatal
T5566	20148-20156	JJ	denotes	synaptic
T5561	20157-20165	NN	denotes	efficacy
T5567	20165-20166	.	denotes	.
T5568	20166-20346	sentence	denotes	In contrast, stimulation of dorsal striatum slices from wild-type mice resulted in IPSP activity, long-term depression, and decreased neuronal activity of striatal efferents [34].
T5569	20167-20169	IN	denotes	In
T5571	20170-20178	NN	denotes	contrast
T5572	20178-20180	,	denotes	,
T5573	20180-20191	NN	denotes	stimulation
T5574	20192-20194	IN	denotes	of
T5575	20195-20201	JJ	denotes	dorsal
T5577	20202-20210	NN	denotes	striatum
T5576	20211-20217	NNS	denotes	slices
T5578	20218-20222	IN	denotes	from
T5579	20223-20227	JJ	denotes	wild
T5581	20227-20228	HYPH	denotes	-
T5580	20228-20232	NN	denotes	type
T5582	20233-20237	NNS	denotes	mice
T5570	20238-20246	VBD	denotes	resulted
T5583	20247-20249	IN	denotes	in
T5584	20250-20254	NN	denotes	IPSP
T5585	20255-20263	NN	denotes	activity
T5586	20263-20265	,	denotes	,
T5587	20265-20269	JJ	denotes	long
T5589	20269-20270	HYPH	denotes	-
T5588	20270-20274	NN	denotes	term
T5590	20275-20285	NN	denotes	depression
T5591	20285-20287	,	denotes	,
T5592	20287-20290	CC	denotes	and
T5593	20291-20300	VBN	denotes	decreased
T5595	20301-20309	JJ	denotes	neuronal
T5594	20310-20318	NN	denotes	activity
T5596	20319-20321	IN	denotes	of
T5597	20322-20330	JJ	denotes	striatal
T5598	20331-20340	NNS	denotes	efferents
T5599	20341-20342	-LRB-	denotes	[
T5600	20342-20344	CD	denotes	34
T5601	20344-20345	-RRB-	denotes	]
T5602	20345-20346	.	denotes	.
T5603	20346-20520	sentence	denotes	Carlsson and colleagues [35] have speculated that dopamine D2R stimulation in the striatum serves to "brake" or diminish excitatory corticostriatal signaling and plasticity.
T5604	20347-20355	NNP	denotes	Carlsson
T5606	20356-20359	CC	denotes	and
T5607	20360-20370	NNS	denotes	colleagues
T5608	20371-20372	-LRB-	denotes	[
T5609	20372-20374	CD	denotes	35
T5610	20374-20375	-RRB-	denotes	]
T5611	20376-20380	VBP	denotes	have
T5605	20381-20391	VBN	denotes	speculated
T5612	20392-20396	IN	denotes	that
T5614	20397-20405	NN	denotes	dopamine
T5615	20406-20409	NN	denotes	D2R
T5616	20410-20421	NN	denotes	stimulation
T5617	20422-20424	IN	denotes	in
T5618	20425-20428	DT	denotes	the
T5619	20429-20437	NN	denotes	striatum
T5613	20438-20444	VBZ	denotes	serves
T5620	20445-20447	TO	denotes	to
T5622	20448-20449	``	denotes	"
T5621	20449-20454	VB	denotes	brake
T5623	20454-20455	''	denotes	"
T5624	20456-20458	CC	denotes	or
T5625	20459-20467	VB	denotes	diminish
T5626	20468-20478	JJ	denotes	excitatory
T5628	20479-20494	JJ	denotes	corticostriatal
T5627	20495-20504	NN	denotes	signaling
T5629	20505-20508	CC	denotes	and
T5630	20509-20519	NN	denotes	plasticity
T5631	20519-20520	.	denotes	.
T5632	20520-20780	sentence	denotes	Indeed, perseverative behavior is associated with over activity of the dorsal striatum in rodents [36] and over activity of the caudate in patients with ADHD [37] and a strong inverse correlation of D2R binding with compulsive behavior has been reported [22].
T5633	20521-20527	RB	denotes	Indeed
T5635	20527-20529	,	denotes	,
T5636	20529-20542	JJ	denotes	perseverative
T5637	20543-20551	NN	denotes	behavior
T5638	20552-20554	VBZ	denotes	is
T5634	20555-20565	VBN	denotes	associated
T5639	20566-20570	IN	denotes	with
T5640	20571-20575	JJ	denotes	over
T5641	20576-20584	NN	denotes	activity
T5642	20585-20587	IN	denotes	of
T5643	20588-20591	DT	denotes	the
T5645	20592-20598	JJ	denotes	dorsal
T5644	20599-20607	NN	denotes	striatum
T5646	20608-20610	IN	denotes	in
T5647	20611-20618	NNS	denotes	rodents
T5648	20619-20620	-LRB-	denotes	[
T5649	20620-20622	CD	denotes	36
T5650	20622-20623	-RRB-	denotes	]
T5651	20624-20627	CC	denotes	and
T5652	20628-20632	JJ	denotes	over
T5653	20633-20641	NN	denotes	activity
T5654	20642-20644	IN	denotes	of
T5655	20645-20648	DT	denotes	the
T5656	20649-20656	NN	denotes	caudate
T5657	20657-20659	IN	denotes	in
T5658	20660-20668	NNS	denotes	patients
T5659	20669-20673	IN	denotes	with
T5660	20674-20678	NN	denotes	ADHD
T5661	20679-20680	-LRB-	denotes	[
T5662	20680-20682	CD	denotes	37
T5663	20682-20683	-RRB-	denotes	]
T5664	20684-20687	CC	denotes	and
T5665	20688-20689	DT	denotes	a
T5667	20690-20696	JJ	denotes	strong
T5668	20697-20704	JJ	denotes	inverse
T5666	20705-20716	NN	denotes	correlation
T5670	20717-20719	IN	denotes	of
T5671	20720-20723	NN	denotes	D2R
T5672	20724-20731	NN	denotes	binding
T5673	20732-20736	IN	denotes	with
T5674	20737-20747	JJ	denotes	compulsive
T5675	20748-20756	NN	denotes	behavior
T5676	20757-20760	VBZ	denotes	has
T5677	20761-20765	VBN	denotes	been
T5669	20766-20774	VBN	denotes	reported
T5678	20775-20776	-LRB-	denotes	[
T5679	20776-20778	CD	denotes	22
T5680	20778-20779	-RRB-	denotes	]
T5681	20779-20780	.	denotes	.
T5682	20780-20967	sentence	denotes	Importantly, our data indicate that the poor performances displayed by the D2R-/- mice are manifestations of reversal learning deficits and not gross motivational or sensory impairments.
T5683	20781-20792	RB	denotes	Importantly
T5685	20792-20794	,	denotes	,
T5686	20794-20797	PRP$	denotes	our
T5687	20798-20802	NNS	denotes	data
T5684	20803-20811	VBP	denotes	indicate
T5688	20812-20816	IN	denotes	that
T5690	20817-20820	DT	denotes	the
T5692	20821-20825	JJ	denotes	poor
T5691	20826-20838	NNS	denotes	performances
T5693	20839-20848	VBN	denotes	displayed
T5694	20849-20851	IN	denotes	by
T5695	20852-20855	DT	denotes	the
T5697	20856-20859	NN	denotes	D2R
T5698	20859-20860	SYM	denotes	-
T5699	20860-20861	HYPH	denotes	/
T5700	20861-20862	SYM	denotes	-
T5696	20863-20867	NNS	denotes	mice
T5689	20868-20871	VBP	denotes	are
T5701	20872-20886	NNS	denotes	manifestations
T5702	20887-20889	IN	denotes	of
T5703	20890-20898	NN	denotes	reversal
T5704	20899-20907	NN	denotes	learning
T5705	20908-20916	NNS	denotes	deficits
T5706	20917-20920	CC	denotes	and
T5707	20921-20924	RB	denotes	not
T5708	20925-20930	JJ	denotes	gross
T5710	20931-20943	JJ	denotes	motivational
T5711	20944-20946	CC	denotes	or
T5712	20947-20954	JJ	denotes	sensory
T5709	20955-20966	NNS	denotes	impairments
T5713	20966-20967	.	denotes	.
T5714	20967-21146	sentence	denotes	We therefore argue that D2Rs participate in signaling or alerting the organism of learning contingency changes during reversal learning and sculpt ongoing goal-directed behavior.
T5715	20968-20970	PRP	denotes	We
T5717	20971-20980	RB	denotes	therefore
T5716	20981-20986	VBP	denotes	argue
T5718	20987-20991	IN	denotes	that
T5720	20992-20996	NNS	denotes	D2Rs
T5719	20997-21008	VBP	denotes	participate
T5721	21009-21011	IN	denotes	in
T5722	21012-21021	VBG	denotes	signaling
T5723	21022-21024	CC	denotes	or
T5724	21025-21033	VBG	denotes	alerting
T5725	21034-21037	DT	denotes	the
T5726	21038-21046	NN	denotes	organism
T5727	21047-21049	IN	denotes	of
T5728	21050-21058	NN	denotes	learning
T5729	21059-21070	NN	denotes	contingency
T5730	21071-21078	NNS	denotes	changes
T5731	21079-21085	IN	denotes	during
T5732	21086-21094	NN	denotes	reversal
T5733	21095-21103	NN	denotes	learning
T5734	21104-21107	CC	denotes	and
T5735	21108-21114	VBP	denotes	sculpt
T5736	21115-21122	JJ	denotes	ongoing
T5738	21123-21127	NN	denotes	goal
T5740	21127-21128	HYPH	denotes	-
T5739	21128-21136	VBN	denotes	directed
T5737	21137-21145	NN	denotes	behavior
T5741	21145-21146	.	denotes	.
T5854	21160-21164	DT	denotes	This
T5855	21165-21170	NN	denotes	study
T5856	21171-21183	VBZ	denotes	demonstrates
T5857	21184-21188	IN	denotes	that
T5859	21189-21198	NN	denotes	signaling
T5860	21199-21201	IN	denotes	by
T5861	21202-21210	NN	denotes	dopamine
T5862	21211-21215	NNS	denotes	D2Rs
T5863	21216-21220	VBZ	denotes	does
T5864	21221-21224	RB	denotes	not
T5858	21225-21232	VB	denotes	mediate
T5865	21233-21236	DT	denotes	the
T5867	21237-21244	JJ	denotes	hedonic
T5866	21245-21250	NN	denotes	value
T5868	21251-21253	IN	denotes	of
T5869	21254-21265	NNS	denotes	reinforcers
T5870	21265-21267	,	denotes	,
T5871	21267-21277	VBG	denotes	supporting
T5872	21278-21281	CC	denotes	and
T5873	21282-21290	VBG	denotes	refining
T5874	21291-21298	JJR	denotes	earlier
T5875	21299-21307	NNS	denotes	findings
T5876	21308-21309	-LRB-	denotes	[
T5878	21309-21310	CD	denotes	1
T5879	21310-21311	,	denotes	,
T5877	21311-21312	CD	denotes	2
T5880	21312-21313	-RRB-	denotes	]
T5881	21313-21314	.	denotes	.
T5882	21314-21506	sentence	denotes	However, mice completely deficient in D2Rs demonstrated disrupted acquisition of discriminative stimulus relationships and an impaired ability to recognize changes in behavioral determinants.
T5883	21315-21322	RB	denotes	However
T5885	21322-21324	,	denotes	,
T5886	21324-21328	NNS	denotes	mice
T5887	21329-21339	RB	denotes	completely
T5888	21340-21349	JJ	denotes	deficient
T5889	21350-21352	IN	denotes	in
T5890	21353-21357	NNS	denotes	D2Rs
T5884	21358-21370	VBD	denotes	demonstrated
T5891	21371-21380	JJ	denotes	disrupted
T5892	21381-21392	NN	denotes	acquisition
T5893	21393-21395	IN	denotes	of
T5894	21396-21410	JJ	denotes	discriminative
T5895	21411-21419	NN	denotes	stimulus
T5896	21420-21433	NNS	denotes	relationships
T5897	21434-21437	CC	denotes	and
T5898	21438-21440	DT	denotes	an
T5900	21441-21449	JJ	denotes	impaired
T5899	21450-21457	NN	denotes	ability
T5901	21458-21460	TO	denotes	to
T5902	21461-21470	VB	denotes	recognize
T5903	21471-21478	NNS	denotes	changes
T5904	21479-21481	IN	denotes	in
T5905	21482-21492	JJ	denotes	behavioral
T5906	21493-21505	NNS	denotes	determinants
T5907	21505-21506	.	denotes	.
T5908	21506-21720	sentence	denotes	Therefore, we suggest that during associative learning or when unexpected reinforcement outcomes are modified (reversal learning) dopamine-driven reinforcement impulses involve signaling mediated by dopamine D2Rs.
T5909	21507-21516	RB	denotes	Therefore
T5911	21516-21518	,	denotes	,
T5912	21518-21520	PRP	denotes	we
T5910	21521-21528	VBP	denotes	suggest
T5913	21529-21533	IN	denotes	that
T5915	21534-21540	IN	denotes	during
T5916	21541-21552	JJ	denotes	associative
T5917	21553-21561	NN	denotes	learning
T5918	21562-21564	CC	denotes	or
T5919	21565-21569	WRB	denotes	when
T5921	21570-21580	JJ	denotes	unexpected
T5923	21581-21594	NN	denotes	reinforcement
T5922	21595-21603	NNS	denotes	outcomes
T5924	21604-21607	VBP	denotes	are
T5920	21608-21616	VBN	denotes	modified
T5925	21617-21618	-LRB-	denotes	(
T5927	21618-21626	NN	denotes	reversal
T5926	21627-21635	NN	denotes	learning
T5928	21635-21636	-RRB-	denotes	)
T5929	21637-21645	NN	denotes	dopamine
T5931	21645-21646	HYPH	denotes	-
T5930	21646-21652	VBN	denotes	driven
T5933	21653-21666	NN	denotes	reinforcement
T5932	21667-21675	NNS	denotes	impulses
T5914	21676-21683	VBP	denotes	involve
T5934	21684-21693	NN	denotes	signaling
T5935	21694-21702	VBN	denotes	mediated
T5936	21703-21705	IN	denotes	by
T5937	21706-21714	NN	denotes	dopamine
T5938	21715-21719	NNS	denotes	D2Rs
T5939	21719-21720	.	denotes	.
T5940	21720-22001	sentence	denotes	In the course of associative learning, striatal synapses [38] receive experience-driven gain [7], thus permitting newly established reinforcement-mediated signals to traverse ascending efferents en route to the frontal cortex, completing a functional limbic/motor circuit [39-41].
T5941	21721-21723	IN	denotes	In
T5943	21724-21727	DT	denotes	the
T5944	21728-21734	NN	denotes	course
T5945	21735-21737	IN	denotes	of
T5946	21738-21749	JJ	denotes	associative
T5947	21750-21758	NN	denotes	learning
T5948	21758-21760	,	denotes	,
T5949	21760-21768	JJ	denotes	striatal
T5950	21769-21777	NNS	denotes	synapses
T5951	21778-21779	-LRB-	denotes	[
T5952	21779-21781	CD	denotes	38
T5953	21781-21782	-RRB-	denotes	]
T5942	21783-21790	VBP	denotes	receive
T5954	21791-21801	NN	denotes	experience
T5956	21801-21802	HYPH	denotes	-
T5955	21802-21808	VBN	denotes	driven
T5957	21809-21813	NN	denotes	gain
T5958	21814-21815	-LRB-	denotes	[
T5959	21815-21816	CD	denotes	7
T5960	21816-21817	-RRB-	denotes	]
T5961	21817-21819	,	denotes	,
T5962	21819-21823	RB	denotes	thus
T5963	21824-21834	VBG	denotes	permitting
T5964	21835-21840	RB	denotes	newly
T5965	21841-21852	VBN	denotes	established
T5967	21853-21866	NN	denotes	reinforcement
T5968	21866-21867	HYPH	denotes	-
T5966	21867-21875	VBN	denotes	mediated
T5969	21876-21883	NNS	denotes	signals
T5970	21884-21886	TO	denotes	to
T5971	21887-21895	VB	denotes	traverse
T5972	21896-21905	VBG	denotes	ascending
T5973	21906-21915	NNS	denotes	efferents
T5974	21916-21918	FW	denotes	en
T5976	21919-21924	FW	denotes	route
T5975	21925-21927	IN	denotes	to
T5977	21928-21931	DT	denotes	the
T5979	21932-21939	JJ	denotes	frontal
T5978	21940-21946	NN	denotes	cortex
T5980	21946-21948	,	denotes	,
T5981	21948-21958	VBG	denotes	completing
T5982	21959-21960	DT	denotes	a
T5984	21961-21971	JJ	denotes	functional
T5985	21972-21978	JJ	denotes	limbic
T5987	21978-21979	HYPH	denotes	/
T5986	21979-21984	JJ	denotes	motor
T5983	21985-21992	NN	denotes	circuit
T5988	21993-21994	-LRB-	denotes	[
T5989	21994-21996	CD	denotes	39
T5990	21996-21997	SYM	denotes	-
T5991	21997-21999	CD	denotes	41
T5992	21999-22000	-RRB-	denotes	]
T5993	22000-22001	.	denotes	.
T5994	22001-22351	sentence	denotes	Possibly, the lack of dopamine D2R-mediated signaling prevents refinement of the corticostriatal reinforcement circuits in the brains of the D2R-/- mice, thus impairing their ability to form S+/S- contingencies and disengage inappropriate dopamine D1R-mediated associative responding when unexpected consequences to goal-directed behaviors happened.
T5995	22002-22010	RB	denotes	Possibly
T5997	22010-22012	,	denotes	,
T5998	22012-22015	DT	denotes	the
T5999	22016-22020	NN	denotes	lack
T6000	22021-22023	IN	denotes	of
T6001	22024-22032	NN	denotes	dopamine
T6002	22033-22036	NN	denotes	D2R
T6004	22036-22037	HYPH	denotes	-
T6003	22037-22045	VBN	denotes	mediated
T6005	22046-22055	NN	denotes	signaling
T5996	22056-22064	VBZ	denotes	prevents
T6006	22065-22075	NN	denotes	refinement
T6007	22076-22078	IN	denotes	of
T6008	22079-22082	DT	denotes	the
T6010	22083-22098	JJ	denotes	corticostriatal
T6011	22099-22112	NN	denotes	reinforcement
T6009	22113-22121	NNS	denotes	circuits
T6012	22122-22124	IN	denotes	in
T6013	22125-22128	DT	denotes	the
T6014	22129-22135	NNS	denotes	brains
T6015	22136-22138	IN	denotes	of
T6016	22139-22142	DT	denotes	the
T6018	22143-22146	NN	denotes	D2R
T6019	22146-22147	SYM	denotes	-
T6020	22147-22148	HYPH	denotes	/
T6021	22148-22149	SYM	denotes	-
T6017	22150-22154	NNS	denotes	mice
T6022	22154-22156	,	denotes	,
T6023	22156-22160	RB	denotes	thus
T6024	22161-22170	VBG	denotes	impairing
T6025	22171-22176	PRP$	denotes	their
T6026	22177-22184	NN	denotes	ability
T6027	22185-22187	TO	denotes	to
T6028	22188-22192	VB	denotes	form
T6029	22193-22194	NN	denotes	S
T6031	22194-22195	SYM	denotes	+
T6032	22195-22196	HYPH	denotes	/
T6033	22196-22197	NN	denotes	S
T6034	22197-22198	HYPH	denotes	-
T6030	22199-22212	NNS	denotes	contingencies
T6035	22213-22216	CC	denotes	and
T6036	22217-22226	VB	denotes	disengage
T6037	22227-22240	JJ	denotes	inappropriate
T6039	22241-22249	NN	denotes	dopamine
T6040	22250-22253	NN	denotes	D1R
T6042	22253-22254	HYPH	denotes	-
T6041	22254-22262	VBN	denotes	mediated
T6043	22263-22274	JJ	denotes	associative
T6038	22275-22285	NN	denotes	responding
T6044	22286-22290	WRB	denotes	when
T6046	22291-22301	JJ	denotes	unexpected
T6047	22302-22314	NNS	denotes	consequences
T6048	22315-22317	IN	denotes	to
T6049	22318-22322	NN	denotes	goal
T6051	22322-22323	HYPH	denotes	-
T6050	22323-22331	VBN	denotes	directed
T6052	22332-22341	NNS	denotes	behaviors
T6045	22342-22350	VBD	denotes	happened
T6053	22350-22351	.	denotes	.
T6054	22351-22592	sentence	denotes	Consequently, we are compelled to conclude that the perseverative performance deficits demonstrated by the D2R-/- mice in the tasks used in the present study reveal a previously unreported role for D2Rs in associative and reversal learning.
T6055	22352-22364	RB	denotes	Consequently
T6057	22364-22366	,	denotes	,
T6058	22366-22368	PRP	denotes	we
T6059	22369-22372	VBP	denotes	are
T6056	22373-22382	VBN	denotes	compelled
T6060	22383-22385	TO	denotes	to
T6061	22386-22394	VB	denotes	conclude
T6062	22395-22399	IN	denotes	that
T6064	22400-22403	DT	denotes	the
T6066	22404-22417	JJ	denotes	perseverative
T6067	22418-22429	NN	denotes	performance
T6065	22430-22438	NNS	denotes	deficits
T6068	22439-22451	VBN	denotes	demonstrated
T6069	22452-22454	IN	denotes	by
T6070	22455-22458	DT	denotes	the
T6072	22459-22462	NN	denotes	D2R
T6073	22462-22463	SYM	denotes	-
T6074	22463-22464	HYPH	denotes	/
T6075	22464-22465	SYM	denotes	-
T6071	22466-22470	NNS	denotes	mice
T6076	22471-22473	IN	denotes	in
T6077	22474-22477	DT	denotes	the
T6078	22478-22483	NNS	denotes	tasks
T6079	22484-22488	VBN	denotes	used
T6080	22489-22491	IN	denotes	in
T6081	22492-22495	DT	denotes	the
T6083	22496-22503	JJ	denotes	present
T6082	22504-22509	NN	denotes	study
T6063	22510-22516	VBP	denotes	reveal
T6084	22517-22518	DT	denotes	a
T6086	22519-22529	RB	denotes	previously
T6087	22530-22540	JJ	denotes	unreported
T6085	22541-22545	NN	denotes	role
T6088	22546-22549	IN	denotes	for
T6089	22550-22554	NNS	denotes	D2Rs
T6090	22555-22557	IN	denotes	in
T6091	22558-22569	JJ	denotes	associative
T6093	22570-22573	CC	denotes	and
T6094	22574-22582	NN	denotes	reversal
T6092	22583-22591	NN	denotes	learning
T6095	22591-22592	.	denotes	.
T6113	22603-22611	NNS	denotes	Subjects
T6114	22611-22890	sentence	denotes	The sixteen, 8–10 week old, 25–30 g mice (8 per genotype) used in this study were the congenic offspring of breeders that were descendants of the original F2 hybrid (129/Sv × C57BL/6J; Kelly et al., 1997) that was backcrossed to inbred C57Bl/6J stock (Jackson Laboratories, ME).
T6115	22612-22615	DT	denotes	The
T6117	22616-22623	CD	denotes	sixteen
T6118	22623-22625	,	denotes	,
T6119	22625-22626	CD	denotes	8
T6121	22626-22627	HYPH	denotes	–
T6120	22627-22629	CD	denotes	10
T6122	22630-22634	NN	denotes	week
T6123	22635-22638	JJ	denotes	old
T6124	22638-22640	,	denotes	,
T6125	22640-22642	CD	denotes	25
T6127	22642-22643	HYPH	denotes	–
T6126	22643-22645	CD	denotes	30
T6128	22646-22647	NN	denotes	g
T6116	22648-22652	NNS	denotes	mice
T6130	22653-22654	-LRB-	denotes	(
T6131	22654-22655	CD	denotes	8
T6132	22656-22659	IN	denotes	per
T6133	22660-22668	NN	denotes	genotype
T6134	22668-22669	-RRB-	denotes	)
T6135	22670-22674	VBN	denotes	used
T6136	22675-22677	IN	denotes	in
T6137	22678-22682	DT	denotes	this
T6138	22683-22688	NN	denotes	study
T6129	22689-22693	VBD	denotes	were
T6139	22694-22697	DT	denotes	the
T6141	22698-22706	JJ	denotes	congenic
T6140	22707-22716	NN	denotes	offspring
T6142	22717-22719	IN	denotes	of
T6143	22720-22728	NNS	denotes	breeders
T6144	22729-22733	WDT	denotes	that
T6145	22734-22738	VBD	denotes	were
T6146	22739-22750	NNS	denotes	descendants
T6147	22751-22753	IN	denotes	of
T6148	22754-22757	DT	denotes	the
T6150	22758-22766	JJ	denotes	original
T6151	22767-22769	NN	denotes	F2
T6149	22770-22776	NN	denotes	hybrid
T6152	22777-22778	-LRB-	denotes	(
T6154	22778-22781	CD	denotes	129
T6155	22781-22782	HYPH	denotes	/
T6153	22782-22784	NN	denotes	Sv
T6156	22785-22786	SYM	denotes	×
T6158	22787-22792	NN	denotes	C57BL
T6159	22792-22793	HYPH	denotes	/
T6157	22793-22795	NN	denotes	6J
T6160	22795-22796	:	denotes	;
T6161	22797-22802	NNP	denotes	Kelly
T6162	22803-22805	FW	denotes	et
T6163	22806-22809	FW	denotes	al.
T6164	22809-22811	,	denotes	,
T6165	22811-22815	CD	denotes	1997
T6166	22815-22816	-RRB-	denotes	)
T6167	22817-22821	WDT	denotes	that
T6169	22822-22825	VBD	denotes	was
T6168	22826-22837	VBN	denotes	backcrossed
T6170	22838-22840	IN	denotes	to
T6171	22841-22847	JJ	denotes	inbred
T6173	22848-22853	NN	denotes	C57Bl
T6175	22853-22854	HYPH	denotes	/
T6174	22854-22856	NN	denotes	6J
T6172	22857-22862	NN	denotes	stock
T6176	22863-22864	-LRB-	denotes	(
T6178	22864-22871	NNP	denotes	Jackson
T6177	22872-22884	NNP	denotes	Laboratories
T6179	22884-22886	,	denotes	,
T6180	22886-22888	NNP	denotes	ME
T6181	22888-22889	-RRB-	denotes	)
T6182	22889-22890	.	denotes	.
T6183	22890-23026	sentence	denotes	This breeding strategy was repeated for 20 successive generations with the gender of the donor/mutant alternating with each generation.
T6184	22891-22895	DT	denotes	This
T6186	22896-22904	NN	denotes	breeding
T6185	22905-22913	NN	denotes	strategy
T6188	22914-22917	VBD	denotes	was
T6187	22918-22926	VBN	denotes	repeated
T6189	22927-22930	IN	denotes	for
T6190	22931-22933	CD	denotes	20
T6192	22934-22944	JJ	denotes	successive
T6191	22945-22956	NNS	denotes	generations
T6193	22957-22961	IN	denotes	with
T6194	22962-22965	DT	denotes	the
T6195	22966-22972	NN	denotes	gender
T6196	22973-22975	IN	denotes	of
T6197	22976-22979	DT	denotes	the
T6199	22980-22985	NN	denotes	donor
T6200	22985-22986	HYPH	denotes	/
T6198	22986-22992	NN	denotes	mutant
T6201	22993-23004	VBG	denotes	alternating
T6202	23005-23009	IN	denotes	with
T6203	23010-23014	DT	denotes	each
T6204	23015-23025	NN	denotes	generation
T6205	23025-23026	.	denotes	.
T6206	23026-23104	sentence	denotes	All experimental subjects were genotyped by PCR as previously described [23].
T6207	23027-23030	DT	denotes	All
T6209	23031-23043	JJ	denotes	experimental
T6208	23044-23052	NNS	denotes	subjects
T6211	23053-23057	VBD	denotes	were
T6210	23058-23067	VBN	denotes	genotyped
T6212	23068-23070	IN	denotes	by
T6213	23071-23074	NN	denotes	PCR
T6214	23075-23077	IN	denotes	as
T6216	23078-23088	RB	denotes	previously
T6215	23089-23098	VBN	denotes	described
T6217	23099-23100	-LRB-	denotes	[
T6218	23100-23102	CD	denotes	23
T6219	23102-23103	-RRB-	denotes	]
T6220	23103-23104	.	denotes	.
T6221	23104-23156	sentence	denotes	All testing occured randomly across estrous cycles.
T6222	23105-23108	DT	denotes	All
T6223	23109-23116	NN	denotes	testing
T6224	23117-23124	VBN	denotes	occured
T6225	23125-23133	RB	denotes	randomly
T6226	23134-23140	IN	denotes	across
T6227	23141-23148	JJ	denotes	estrous
T6228	23149-23155	NNS	denotes	cycles
T6229	23155-23156	.	denotes	.
T6230	23156-23390	sentence	denotes	The Department of Comparative Medicine at Oregon Health and Science University approved all protocols, and all animals were maintained in accordance to National Institutes of Health's Guide for the Care and Use of Laboratory Animals.
T6231	23157-23160	DT	denotes	The
T6232	23161-23171	NNP	denotes	Department
T6234	23172-23174	IN	denotes	of
T6235	23175-23186	NNP	denotes	Comparative
T6236	23187-23195	NNP	denotes	Medicine
T6237	23196-23198	IN	denotes	at
T6238	23199-23205	NNP	denotes	Oregon
T6240	23206-23212	NNP	denotes	Health
T6241	23213-23216	CC	denotes	and
T6242	23217-23224	NNP	denotes	Science
T6239	23225-23235	NNP	denotes	University
T6233	23236-23244	VBD	denotes	approved
T6243	23245-23248	DT	denotes	all
T6244	23249-23258	NNS	denotes	protocols
T6245	23258-23260	,	denotes	,
T6246	23260-23263	CC	denotes	and
T6247	23264-23267	DT	denotes	all
T6248	23268-23275	NNS	denotes	animals
T6250	23276-23280	VBD	denotes	were
T6249	23281-23291	VBN	denotes	maintained
T6251	23292-23294	IN	denotes	in
T6252	23295-23305	NN	denotes	accordance
T6253	23306-23308	IN	denotes	to
T6254	23309-23317	NNP	denotes	National
T6255	23318-23328	NNPS	denotes	Institutes
T6257	23329-23331	IN	denotes	of
T6258	23332-23338	NNP	denotes	Health
T6259	23338-23340	POS	denotes	's
T6256	23341-23346	NN	denotes	Guide
T6260	23347-23350	IN	denotes	for
T6261	23351-23354	DT	denotes	the
T6262	23355-23359	NNP	denotes	Care
T6263	23360-23363	CC	denotes	and
T6264	23364-23367	NNP	denotes	Use
T6265	23368-23370	IN	denotes	of
T6266	23371-23381	NNP	denotes	Laboratory
T6267	23382-23389	NNPS	denotes	Animals
T6268	23389-23390	.	denotes	.
T6404	23392-23404	JJ	denotes	Experimental
T6405	23405-23415	NNS	denotes	procedures
T6406	23415-23457	sentence	denotes	Odor discrimination training and testing
T6407	23417-23421	NN	denotes	Odor
T6409	23422-23436	NN	denotes	discrimination
T6408	23437-23445	NN	denotes	training
T6410	23446-23449	CC	denotes	and
T6411	23450-23457	NN	denotes	testing
T6412	23457-23578	sentence	denotes	A 2-odor discrimination paradigm was chosen because it permits a measure of attentional focus in goal-directed behavior.
T6413	23458-23459	DT	denotes	A
T6415	23460-23461	CD	denotes	2
T6417	23461-23462	HYPH	denotes	-
T6416	23462-23466	NN	denotes	odor
T6418	23467-23481	NN	denotes	discrimination
T6414	23482-23490	NN	denotes	paradigm
T6420	23491-23494	VBD	denotes	was
T6419	23495-23501	VBN	denotes	chosen
T6421	23502-23509	IN	denotes	because
T6423	23510-23512	PRP	denotes	it
T6422	23513-23520	VBZ	denotes	permits
T6424	23521-23522	DT	denotes	a
T6425	23523-23530	NN	denotes	measure
T6426	23531-23533	IN	denotes	of
T6427	23534-23545	JJ	denotes	attentional
T6428	23546-23551	NN	denotes	focus
T6429	23552-23554	IN	denotes	in
T6430	23555-23559	NN	denotes	goal
T6432	23559-23560	HYPH	denotes	-
T6431	23560-23568	VBN	denotes	directed
T6433	23569-23577	NN	denotes	behavior
T6434	23577-23578	.	denotes	.
T6435	23578-23688	sentence	denotes	Odor discrimination was chosen as the particular task because it is a highly robust behavior in rodents [18].
T6436	23579-23583	NN	denotes	Odor
T6437	23584-23598	NN	denotes	discrimination
T6439	23599-23602	VBD	denotes	was
T6438	23603-23609	VBN	denotes	chosen
T6440	23610-23612	IN	denotes	as
T6441	23613-23616	DT	denotes	the
T6443	23617-23627	JJ	denotes	particular
T6442	23628-23632	NN	denotes	task
T6444	23633-23640	IN	denotes	because
T6446	23641-23643	PRP	denotes	it
T6445	23644-23646	VBZ	denotes	is
T6447	23647-23648	DT	denotes	a
T6449	23649-23655	RB	denotes	highly
T6450	23656-23662	JJ	denotes	robust
T6448	23663-23671	NN	denotes	behavior
T6451	23672-23674	IN	denotes	in
T6452	23675-23682	NNS	denotes	rodents
T6453	23683-23684	-LRB-	denotes	[
T6454	23684-23686	CD	denotes	18
T6455	23686-23687	-RRB-	denotes	]
T6456	23687-23688	.	denotes	.
T6457	23688-23775	sentence	denotes	To minimize experimental error, the experimenter was blind to genotype during testing.
T6458	23689-23691	TO	denotes	To
T6459	23692-23700	VB	denotes	minimize
T6461	23701-23713	JJ	denotes	experimental
T6462	23714-23719	NN	denotes	error
T6463	23719-23721	,	denotes	,
T6464	23721-23724	DT	denotes	the
T6465	23725-23737	NN	denotes	experimenter
T6460	23738-23741	VBD	denotes	was
T6466	23742-23747	JJ	denotes	blind
T6467	23748-23750	IN	denotes	to
T6468	23751-23759	NN	denotes	genotype
T6469	23760-23766	IN	denotes	during
T6470	23767-23774	NN	denotes	testing
T6471	23774-23775	.	denotes	.
T6472	23775-23846	sentence	denotes	Mice were mildly food deprived to approximately 85% ad libitum weight.
T6473	23776-23780	NNS	denotes	Mice
T6474	23781-23785	VBD	denotes	were
T6475	23786-23792	RB	denotes	mildly
T6477	23793-23797	NN	denotes	food
T6476	23798-23806	VBN	denotes	deprived
T6478	23807-23809	IN	denotes	to
T6479	23810-23823	RB	denotes	approximately
T6480	23824-23826	CD	denotes	85
T6481	23826-23827	NN	denotes	%
T6483	23828-23830	FW	denotes	ad
T6484	23831-23838	FW	denotes	libitum
T6482	23839-23845	NN	denotes	weight
T6485	23845-23846	.	denotes	.
T6486	23846-24131	sentence	denotes	Dopamine D2R-/- and D2R+/+ mice (n = 8 per group) were initially trained to ambulate the length of a polyvinyl mouse cage (30-cm) to retrieve ~30-mg of Pico® fat supplemented rodent food located in a small plastic cup (3-cm) attached to the floor of the testing apparatus with Velcro.
T6487	23847-23855	NN	denotes	Dopamine
T6488	23856-23859	NN	denotes	D2R
T6490	23859-23860	SYM	denotes	-
T6491	23860-23861	HYPH	denotes	/
T6492	23861-23862	SYM	denotes	-
T6493	23863-23866	CC	denotes	and
T6494	23867-23870	NN	denotes	D2R
T6495	23870-23871	SYM	denotes	+
T6496	23871-23872	HYPH	denotes	/
T6497	23872-23873	SYM	denotes	+
T6489	23874-23878	NNS	denotes	mice
T6499	23879-23880	-LRB-	denotes	(
T6501	23880-23881	NN	denotes	n
T6502	23882-23883	SYM	denotes	=
T6500	23884-23885	CD	denotes	8
T6503	23886-23889	IN	denotes	per
T6504	23890-23895	NN	denotes	group
T6505	23895-23896	-RRB-	denotes	)
T6506	23897-23901	VBD	denotes	were
T6507	23902-23911	RB	denotes	initially
T6498	23912-23919	VBN	denotes	trained
T6508	23920-23922	TO	denotes	to
T6509	23923-23931	VB	denotes	ambulate
T6510	23932-23935	DT	denotes	the
T6511	23936-23942	NN	denotes	length
T6512	23943-23945	IN	denotes	of
T6513	23946-23947	DT	denotes	a
T6515	23948-23957	NN	denotes	polyvinyl
T6516	23958-23963	NN	denotes	mouse
T6514	23964-23968	NN	denotes	cage
T6517	23969-23970	-LRB-	denotes	(
T6519	23970-23972	CD	denotes	30
T6520	23972-23973	HYPH	denotes	-
T6518	23973-23975	NNS	denotes	cm
T6521	23975-23976	-RRB-	denotes	)
T6522	23977-23979	TO	denotes	to
T6523	23980-23988	VB	denotes	retrieve
T6524	23989-23990	SYM	denotes	~
T6525	23990-23992	CD	denotes	30
T6527	23992-23993	HYPH	denotes	-
T6526	23993-23995	NNS	denotes	mg
T6528	23996-23998	IN	denotes	of
T6529	23999-24004	NNP	denotes	Pico®
T6530	24005-24008	NN	denotes	fat
T6531	24009-24021	VBN	denotes	supplemented
T6533	24022-24028	NN	denotes	rodent
T6532	24029-24033	NN	denotes	food
T6534	24034-24041	VBN	denotes	located
T6535	24042-24044	IN	denotes	in
T6536	24045-24046	DT	denotes	a
T6538	24047-24052	JJ	denotes	small
T6539	24053-24060	NN	denotes	plastic
T6537	24061-24064	NN	denotes	cup
T6540	24065-24066	-LRB-	denotes	(
T6542	24066-24067	CD	denotes	3
T6543	24067-24068	HYPH	denotes	-
T6541	24068-24070	NNS	denotes	cm
T6544	24070-24071	-RRB-	denotes	)
T6545	24072-24080	VBN	denotes	attached
T6546	24081-24083	IN	denotes	to
T6547	24084-24087	DT	denotes	the
T6548	24088-24093	NN	denotes	floor
T6549	24094-24096	IN	denotes	of
T6550	24097-24100	DT	denotes	the
T6552	24101-24108	NN	denotes	testing
T6551	24109-24118	NN	denotes	apparatus
T6553	24119-24123	IN	denotes	with
T6554	24124-24130	NNP	denotes	Velcro
T6555	24130-24131	.	denotes	.
T6556	24131-24288	sentence	denotes	Each subject received five trials, and the latency to locate and start to consume the food pellet was recorded manually with a standard hand-held stopwatch.
T6557	24132-24136	DT	denotes	Each
T6558	24137-24144	NN	denotes	subject
T6559	24145-24153	VBD	denotes	received
T6560	24154-24158	CD	denotes	five
T6561	24159-24165	NNS	denotes	trials
T6562	24165-24167	,	denotes	,
T6563	24167-24170	CC	denotes	and
T6564	24171-24174	DT	denotes	the
T6565	24175-24182	NN	denotes	latency
T6567	24183-24185	TO	denotes	to
T6568	24186-24192	VB	denotes	locate
T6569	24193-24196	CC	denotes	and
T6570	24197-24202	VB	denotes	start
T6571	24203-24205	TO	denotes	to
T6572	24206-24213	VB	denotes	consume
T6573	24214-24217	DT	denotes	the
T6575	24218-24222	NN	denotes	food
T6574	24223-24229	NN	denotes	pellet
T6576	24230-24233	VBD	denotes	was
T6566	24234-24242	VBN	denotes	recorded
T6577	24243-24251	RB	denotes	manually
T6578	24252-24256	IN	denotes	with
T6579	24257-24258	DT	denotes	a
T6581	24259-24267	JJ	denotes	standard
T6582	24268-24272	JJ	denotes	hand
T6584	24272-24273	HYPH	denotes	-
T6583	24273-24277	JJ	denotes	held
T6580	24278-24287	NN	denotes	stopwatch
T6585	24287-24288	.	denotes	.
T6586	24288-24466	sentence	denotes	Twenty-four hours later subjects were trained to ambulate towards and dig through the same 3-cm dish filled with sterile sand to locate a food pellet buried underneath the sand.
T6587	24289-24295	CD	denotes	Twenty
T6589	24295-24296	HYPH	denotes	-
T6588	24296-24300	CD	denotes	four
T6590	24301-24306	NNS	denotes	hours
T6591	24307-24312	RB	denotes	later
T6593	24313-24321	NNS	denotes	subjects
T6594	24322-24326	VBD	denotes	were
T6592	24327-24334	VBN	denotes	trained
T6595	24335-24337	TO	denotes	to
T6596	24338-24346	VB	denotes	ambulate
T6597	24347-24354	IN	denotes	towards
T6598	24355-24358	CC	denotes	and
T6599	24359-24362	VB	denotes	dig
T6600	24363-24370	IN	denotes	through
T6601	24371-24374	DT	denotes	the
T6603	24375-24379	JJ	denotes	same
T6604	24380-24381	CD	denotes	3
T6606	24381-24382	HYPH	denotes	-
T6605	24382-24384	NN	denotes	cm
T6602	24385-24389	NN	denotes	dish
T6607	24390-24396	VBN	denotes	filled
T6608	24397-24401	IN	denotes	with
T6609	24402-24409	JJ	denotes	sterile
T6610	24410-24414	NN	denotes	sand
T6611	24415-24417	TO	denotes	to
T6612	24418-24424	VB	denotes	locate
T6613	24425-24426	DT	denotes	a
T6615	24427-24431	NN	denotes	food
T6614	24432-24438	NN	denotes	pellet
T6616	24439-24445	VBN	denotes	buried
T6617	24446-24456	IN	denotes	underneath
T6618	24457-24460	DT	denotes	the
T6619	24461-24465	NN	denotes	sand
T6620	24465-24466	.	denotes	.
T6621	24466-24495	sentence	denotes	Subjects received 10 trials.
T6622	24467-24475	NNS	denotes	Subjects
T6623	24476-24484	VBD	denotes	received
T6624	24485-24487	CD	denotes	10
T6625	24488-24494	NNS	denotes	trials
T6626	24494-24495	.	denotes	.
T6627	24495-24629	sentence	denotes	If a mouse failed to locate a food pellet within 10-min of the first trial, an additional food pellet was dropped on top of the dish.
T6628	24496-24498	IN	denotes	If
T6630	24499-24500	DT	denotes	a
T6631	24501-24506	NN	denotes	mouse
T6629	24507-24513	VBD	denotes	failed
T6633	24514-24516	TO	denotes	to
T6634	24517-24523	VB	denotes	locate
T6635	24524-24525	DT	denotes	a
T6637	24526-24530	NN	denotes	food
T6636	24531-24537	NN	denotes	pellet
T6638	24538-24544	IN	denotes	within
T6639	24545-24547	CD	denotes	10
T6641	24547-24548	HYPH	denotes	-
T6640	24548-24551	NN	denotes	min
T6642	24552-24554	IN	denotes	of
T6643	24555-24558	DT	denotes	the
T6645	24559-24564	JJ	denotes	first
T6644	24565-24570	NN	denotes	trial
T6646	24570-24572	,	denotes	,
T6647	24572-24574	DT	denotes	an
T6649	24575-24585	JJ	denotes	additional
T6650	24586-24590	NN	denotes	food
T6648	24591-24597	NN	denotes	pellet
T6651	24598-24601	VBD	denotes	was
T6632	24602-24609	VBN	denotes	dropped
T6652	24610-24612	IN	denotes	on
T6653	24613-24616	NN	denotes	top
T6654	24617-24619	IN	denotes	of
T6655	24620-24623	DT	denotes	the
T6656	24624-24628	NN	denotes	dish
T6657	24628-24629	.	denotes	.
T6658	24629-24756	sentence	denotes	This manipulation usually ensured that a subject would dig through the sand to locate the original pellet and learn this task.
T6659	24630-24634	DT	denotes	This
T6660	24635-24647	NN	denotes	manipulation
T6662	24648-24655	RB	denotes	usually
T6661	24656-24663	VBD	denotes	ensured
T6663	24664-24668	IN	denotes	that
T6665	24669-24670	DT	denotes	a
T6666	24671-24678	NN	denotes	subject
T6667	24679-24684	MD	denotes	would
T6664	24685-24688	VB	denotes	dig
T6668	24689-24696	IN	denotes	through
T6669	24697-24700	DT	denotes	the
T6670	24701-24705	NN	denotes	sand
T6671	24706-24708	TO	denotes	to
T6672	24709-24715	VB	denotes	locate
T6673	24716-24719	DT	denotes	the
T6675	24720-24728	JJ	denotes	original
T6674	24729-24735	NN	denotes	pellet
T6676	24736-24739	CC	denotes	and
T6677	24740-24745	VB	denotes	learn
T6678	24746-24750	DT	denotes	this
T6679	24751-24755	NN	denotes	task
T6680	24755-24756	.	denotes	.
T6681	24756-24885	sentence	denotes	The next day, mice were presented to the testing apparatus that now contained 2 dishes, each filled with different scented sand.
T6682	24757-24760	DT	denotes	The
T6684	24761-24765	JJ	denotes	next
T6683	24766-24769	NN	denotes	day
T6686	24769-24771	,	denotes	,
T6687	24771-24775	NNS	denotes	mice
T6688	24776-24780	VBD	denotes	were
T6685	24781-24790	VBN	denotes	presented
T6689	24791-24793	IN	denotes	to
T6690	24794-24797	DT	denotes	the
T6692	24798-24805	NN	denotes	testing
T6691	24806-24815	NN	denotes	apparatus
T6693	24816-24820	WDT	denotes	that
T6695	24821-24824	RB	denotes	now
T6694	24825-24834	VBD	denotes	contained
T6696	24835-24836	CD	denotes	2
T6697	24837-24843	NNS	denotes	dishes
T6698	24843-24845	,	denotes	,
T6699	24845-24849	DT	denotes	each
T6700	24850-24856	VBN	denotes	filled
T6701	24857-24861	IN	denotes	with
T6702	24862-24871	JJ	denotes	different
T6703	24872-24879	JJ	denotes	scented
T6704	24880-24884	NN	denotes	sand
T6705	24884-24885	.	denotes	.
T6706	24885-25063	sentence	denotes	One odor signaled that a food reinforcer was buried in that particular dish (S+) while the other odor signaled that no reinforcer was contained within that particular dish (S-).
T6707	24886-24889	CD	denotes	One
T6708	24890-24894	NN	denotes	odor
T6709	24895-24903	VBD	denotes	signaled
T6710	24904-24908	IN	denotes	that
T6712	24909-24910	DT	denotes	a
T6714	24911-24915	NN	denotes	food
T6713	24916-24926	NN	denotes	reinforcer
T6715	24927-24930	VBD	denotes	was
T6711	24931-24937	VBN	denotes	buried
T6716	24938-24940	IN	denotes	in
T6717	24941-24945	DT	denotes	that
T6719	24946-24956	JJ	denotes	particular
T6718	24957-24961	NN	denotes	dish
T6720	24962-24963	-LRB-	denotes	(
T6721	24963-24964	NN	denotes	S
T6722	24964-24965	SYM	denotes	+
T6723	24965-24966	-RRB-	denotes	)
T6724	24967-24972	IN	denotes	while
T6726	24973-24976	DT	denotes	the
T6728	24977-24982	JJ	denotes	other
T6727	24983-24987	NN	denotes	odor
T6725	24988-24996	VBD	denotes	signaled
T6729	24997-25001	IN	denotes	that
T6731	25002-25004	DT	denotes	no
T6732	25005-25015	NN	denotes	reinforcer
T6733	25016-25019	VBD	denotes	was
T6730	25020-25029	VBN	denotes	contained
T6734	25030-25036	IN	denotes	within
T6735	25037-25041	DT	denotes	that
T6737	25042-25052	JJ	denotes	particular
T6736	25053-25057	NN	denotes	dish
T6738	25058-25059	-LRB-	denotes	(
T6739	25059-25060	NN	denotes	S
T6740	25060-25061	SYM	denotes	-
T6741	25061-25062	-RRB-	denotes	)
T6742	25062-25063	.	denotes	.
T6743	25063-25227	sentence	denotes	The sand was scented by adding 0.80 grams of either cinnamon or dill weed to 98.8 grams of autoclaved playground sand purchased from a local farm and garden store.
T6744	25064-25067	DT	denotes	The
T6745	25068-25072	NN	denotes	sand
T6747	25073-25076	VBD	denotes	was
T6746	25077-25084	VBN	denotes	scented
T6748	25085-25087	IN	denotes	by
T6749	25088-25094	VBG	denotes	adding
T6750	25095-25099	CD	denotes	0.80
T6751	25100-25105	NNS	denotes	grams
T6752	25106-25108	IN	denotes	of
T6753	25109-25115	CC	denotes	either
T6754	25116-25124	NN	denotes	cinnamon
T6755	25125-25127	CC	denotes	or
T6756	25128-25132	NN	denotes	dill
T6757	25133-25137	NN	denotes	weed
T6758	25138-25140	IN	denotes	to
T6759	25141-25145	CD	denotes	98.8
T6760	25146-25151	NNS	denotes	grams
T6761	25152-25154	IN	denotes	of
T6762	25155-25165	JJ	denotes	autoclaved
T6764	25166-25176	NN	denotes	playground
T6763	25177-25181	NN	denotes	sand
T6765	25182-25191	VBN	denotes	purchased
T6766	25192-25196	IN	denotes	from
T6767	25197-25198	DT	denotes	a
T6769	25199-25204	JJ	denotes	local
T6770	25205-25209	NN	denotes	farm
T6771	25210-25213	CC	denotes	and
T6772	25214-25220	NN	denotes	garden
T6768	25221-25226	NN	denotes	store
T6773	25226-25227	.	denotes	.
T6774	25227-25374	sentence	denotes	Finally, 0.40 grams of finely ground food was mixed with the scented sand in order to mask any odor emitted by the food reinforcer in the S+ dish.
T6775	25228-25235	RB	denotes	Finally
T6777	25235-25237	,	denotes	,
T6778	25237-25241	CD	denotes	0.40
T6779	25242-25247	NNS	denotes	grams
T6780	25248-25250	IN	denotes	of
T6781	25251-25257	RB	denotes	finely
T6782	25258-25264	VBN	denotes	ground
T6783	25265-25269	NN	denotes	food
T6784	25270-25273	VBD	denotes	was
T6776	25274-25279	VBN	denotes	mixed
T6785	25280-25284	IN	denotes	with
T6786	25285-25288	DT	denotes	the
T6788	25289-25296	VBN	denotes	scented
T6787	25297-25301	NN	denotes	sand
T6789	25302-25304	IN	denotes	in
T6790	25305-25310	NN	denotes	order
T6791	25311-25313	TO	denotes	to
T6792	25314-25318	VB	denotes	mask
T6793	25319-25322	DT	denotes	any
T6794	25323-25327	NN	denotes	odor
T6795	25328-25335	VBN	denotes	emitted
T6796	25336-25338	IN	denotes	by
T6797	25339-25342	DT	denotes	the
T6799	25343-25347	NN	denotes	food
T6798	25348-25358	NN	denotes	reinforcer
T6800	25359-25361	IN	denotes	in
T6801	25362-25365	DT	denotes	the
T6803	25366-25367	NN	denotes	S
T6804	25367-25368	SYM	denotes	+
T6802	25369-25373	NN	denotes	dish
T6805	25373-25374	.	denotes	.
T6806	25374-25441	sentence	denotes	This final mixture did not appear to be palatable to the subjects.
T6807	25375-25379	DT	denotes	This
T6809	25380-25385	JJ	denotes	final
T6808	25386-25393	NN	denotes	mixture
T6811	25394-25397	VBD	denotes	did
T6812	25398-25401	RB	denotes	not
T6810	25402-25408	VB	denotes	appear
T6813	25409-25411	TO	denotes	to
T6814	25412-25414	VB	denotes	be
T6815	25415-25424	JJ	denotes	palatable
T6816	25425-25427	IN	denotes	to
T6817	25428-25431	DT	denotes	the
T6818	25432-25440	NNS	denotes	subjects
T6819	25440-25441	.	denotes	.
T6820	25441-25571	sentence	denotes	A trial terminated when the mouse: dug in the correct dish and consumed the hidden pellet, or began to dig in the incorrect dish.
T6821	25442-25443	DT	denotes	A
T6822	25444-25449	NN	denotes	trial
T6823	25450-25460	VBN	denotes	terminated
T6824	25461-25465	WRB	denotes	when
T6826	25466-25469	DT	denotes	the
T6827	25470-25475	NN	denotes	mouse
T6828	25475-25477	:	denotes	:
T6825	25477-25480	VBD	denotes	dug
T6829	25481-25483	IN	denotes	in
T6830	25484-25487	DT	denotes	the
T6832	25488-25495	JJ	denotes	correct
T6831	25496-25500	NN	denotes	dish
T6833	25501-25504	CC	denotes	and
T6834	25505-25513	VBD	denotes	consumed
T6835	25514-25517	DT	denotes	the
T6837	25518-25524	JJ	denotes	hidden
T6836	25525-25531	NN	denotes	pellet
T6838	25531-25533	,	denotes	,
T6839	25533-25535	CC	denotes	or
T6840	25536-25541	VBD	denotes	began
T6841	25542-25544	TO	denotes	to
T6842	25545-25548	VB	denotes	dig
T6843	25549-25551	IN	denotes	in
T6844	25552-25555	DT	denotes	the
T6846	25556-25565	JJ	denotes	incorrect
T6845	25566-25570	NN	denotes	dish
T6847	25570-25571	.	denotes	.
T6848	25571-25667	sentence	denotes	Digging was considered the actual physical displacement of sand with the forepaws and/or snout.
T6849	25572-25579	VBG	denotes	Digging
T6851	25580-25583	VBD	denotes	was
T6850	25584-25594	VBN	denotes	considered
T6852	25595-25598	DT	denotes	the
T6854	25599-25605	JJ	denotes	actual
T6855	25606-25614	JJ	denotes	physical
T6853	25615-25627	NN	denotes	displacement
T6856	25628-25630	IN	denotes	of
T6857	25631-25635	NN	denotes	sand
T6858	25636-25640	IN	denotes	with
T6859	25641-25644	DT	denotes	the
T6860	25645-25653	NNS	denotes	forepaws
T6861	25654-25657	CC	denotes	and
T6862	25657-25658	HYPH	denotes	/
T6863	25658-25660	CC	denotes	or
T6864	25661-25666	NN	denotes	snout
T6865	25666-25667	.	denotes	.
T6866	25667-25782	sentence	denotes	Placing forelimbs on either of the dishes and sniffing was not considered digging and was not penalized or scored.
T6867	25668-25675	VBG	denotes	Placing
T6869	25676-25685	NNS	denotes	forelimbs
T6870	25686-25688	IN	denotes	on
T6871	25689-25695	DT	denotes	either
T6872	25696-25698	IN	denotes	of
T6873	25699-25702	DT	denotes	the
T6874	25703-25709	NNS	denotes	dishes
T6875	25710-25713	CC	denotes	and
T6876	25714-25722	VBG	denotes	sniffing
T6877	25723-25726	VBD	denotes	was
T6878	25727-25730	RB	denotes	not
T6868	25731-25741	VBN	denotes	considered
T6879	25742-25749	NN	denotes	digging
T6880	25750-25753	CC	denotes	and
T6881	25754-25757	VBD	denotes	was
T6883	25758-25761	RB	denotes	not
T6882	25762-25771	VBN	denotes	penalized
T6884	25772-25774	CC	denotes	or
T6885	25775-25781	VBN	denotes	scored
T6886	25781-25782	.	denotes	.
T6887	25782-25857	sentence	denotes	Each completed trial was separated by a 20-sec inter-trial-interval (ITI).
T6888	25783-25787	DT	denotes	Each
T6890	25788-25797	JJ	denotes	completed
T6889	25798-25803	NN	denotes	trial
T6892	25804-25807	VBD	denotes	was
T6891	25808-25817	VBN	denotes	separated
T6893	25818-25820	IN	denotes	by
T6894	25821-25822	DT	denotes	a
T6896	25823-25825	CD	denotes	20
T6897	25825-25826	HYPH	denotes	-
T6895	25826-25829	NN	denotes	sec
T6898	25830-25841	NN	denotes	inter-trial
T6900	25841-25842	HYPH	denotes	-
T6899	25842-25850	NN	denotes	interval
T6901	25851-25852	-LRB-	denotes	(
T6902	25852-25855	NN	denotes	ITI
T6903	25855-25856	-RRB-	denotes	)
T6904	25856-25857	.	denotes	.
T6905	25857-26084	sentence	denotes	Preliminary experiments demonstrated that an extended time-out period following an incorrect response was not required to ensure goal-directed behavior in the wild-type or mutant mice for this particular task (data not shown).
T6906	25858-25869	JJ	denotes	Preliminary
T6907	25870-25881	NNS	denotes	experiments
T6908	25882-25894	VBD	denotes	demonstrated
T6909	25895-25899	IN	denotes	that
T6911	25900-25902	DT	denotes	an
T6913	25903-25911	VBN	denotes	extended
T6914	25912-25916	NN	denotes	time
T6915	25916-25917	HYPH	denotes	-
T6916	25917-25920	RP	denotes	out
T6912	25921-25927	NN	denotes	period
T6917	25928-25937	VBG	denotes	following
T6918	25938-25940	DT	denotes	an
T6920	25941-25950	JJ	denotes	incorrect
T6919	25951-25959	NN	denotes	response
T6921	25960-25963	VBD	denotes	was
T6922	25964-25967	RB	denotes	not
T6910	25968-25976	VBN	denotes	required
T6923	25977-25979	TO	denotes	to
T6924	25980-25986	VB	denotes	ensure
T6925	25987-25991	NN	denotes	goal
T6927	25991-25992	HYPH	denotes	-
T6926	25992-26000	VBN	denotes	directed
T6928	26001-26009	NN	denotes	behavior
T6929	26010-26012	IN	denotes	in
T6930	26013-26016	DT	denotes	the
T6932	26017-26021	JJ	denotes	wild
T6934	26021-26022	HYPH	denotes	-
T6933	26022-26026	NN	denotes	type
T6935	26027-26029	CC	denotes	or
T6936	26030-26036	JJ	denotes	mutant
T6931	26037-26041	NNS	denotes	mice
T6937	26042-26045	IN	denotes	for
T6938	26046-26050	DT	denotes	this
T6940	26051-26061	JJ	denotes	particular
T6939	26062-26066	NN	denotes	task
T6941	26067-26068	-LRB-	denotes	(
T6943	26068-26072	NNS	denotes	data
T6944	26073-26076	RB	denotes	not
T6942	26077-26082	VBN	denotes	shown
T6945	26082-26083	-RRB-	denotes	)
T6946	26083-26084	.	denotes	.
T6947	26084-26173	sentence	denotes	Therefore, the 20-sec ITI was used to separate all trials (successful and unsuccessful).
T6948	26085-26094	RB	denotes	Therefore
T6950	26094-26096	,	denotes	,
T6951	26096-26099	DT	denotes	the
T6953	26100-26102	CD	denotes	20
T6955	26102-26103	HYPH	denotes	-
T6954	26103-26106	NN	denotes	sec
T6952	26107-26110	NN	denotes	ITI
T6956	26111-26114	VBD	denotes	was
T6949	26115-26119	VBN	denotes	used
T6957	26120-26122	TO	denotes	to
T6958	26123-26131	VB	denotes	separate
T6959	26132-26135	DT	denotes	all
T6960	26136-26142	NNS	denotes	trials
T6961	26143-26144	-LRB-	denotes	(
T6962	26144-26154	JJ	denotes	successful
T6963	26155-26158	CC	denotes	and
T6964	26159-26171	JJ	denotes	unsuccessful
T6965	26171-26172	-RRB-	denotes	)
T6966	26172-26173	.	denotes	.
T6967	26173-26334	sentence	denotes	The S+ and S- scents were counterbalanced across subjects in order to control for potential scent bias (pilot data suggest there are no biases, data not shown).
T6968	26174-26177	DT	denotes	The
T6970	26178-26179	NN	denotes	S
T6971	26179-26180	SYM	denotes	+
T6972	26181-26184	CC	denotes	and
T6973	26185-26186	NN	denotes	S
T6974	26186-26187	SYM	denotes	-
T6969	26188-26194	NNS	denotes	scents
T6976	26195-26199	VBD	denotes	were
T6975	26200-26215	VBN	denotes	counterbalanced
T6977	26216-26222	IN	denotes	across
T6978	26223-26231	NNS	denotes	subjects
T6979	26232-26234	IN	denotes	in
T6980	26235-26240	NN	denotes	order
T6981	26241-26243	TO	denotes	to
T6982	26244-26251	VB	denotes	control
T6983	26252-26255	IN	denotes	for
T6984	26256-26265	JJ	denotes	potential
T6986	26266-26271	JJ	denotes	scent
T6985	26272-26276	NN	denotes	bias
T6987	26277-26278	-LRB-	denotes	(
T6989	26278-26283	NN	denotes	pilot
T6990	26284-26288	NNS	denotes	data
T6991	26289-26296	VBP	denotes	suggest
T6992	26297-26302	EX	denotes	there
T6993	26303-26306	VBP	denotes	are
T6994	26307-26309	DT	denotes	no
T6995	26310-26316	NNS	denotes	biases
T6996	26316-26318	,	denotes	,
T6997	26318-26322	NNS	denotes	data
T6998	26323-26326	RB	denotes	not
T6988	26327-26332	VBN	denotes	shown
T6999	26332-26333	-RRB-	denotes	)
T7000	26333-26334	.	denotes	.
T7001	26334-26454	sentence	denotes	Following accurate discrimination, defined as 8 correct retrievals across 10 consecutive trials, reversal trials began.
T7002	26335-26344	VBG	denotes	Following
T7004	26345-26353	JJ	denotes	accurate
T7005	26354-26368	NN	denotes	discrimination
T7006	26368-26370	,	denotes	,
T7007	26370-26377	VBN	denotes	defined
T7008	26378-26380	IN	denotes	as
T7009	26381-26382	CD	denotes	8
T7011	26383-26390	JJ	denotes	correct
T7010	26391-26401	NNS	denotes	retrievals
T7012	26402-26408	IN	denotes	across
T7013	26409-26411	CD	denotes	10
T7015	26412-26423	JJ	denotes	consecutive
T7014	26424-26430	NNS	denotes	trials
T7016	26430-26432	,	denotes	,
T7017	26432-26440	NN	denotes	reversal
T7018	26441-26447	NNS	denotes	trials
T7003	26448-26453	VBD	denotes	began
T7019	26453-26454	.	denotes	.
T7020	26454-26485	sentence	denotes	Reversal learning measurement
T7021	26456-26464	NN	denotes	Reversal
T7022	26465-26473	NN	denotes	learning
T7023	26474-26485	NN	denotes	measurement
T7024	26485-26720	sentence	denotes	We next investigated the contribution of dopamine D2Rs to reversal learning behavior by inverting the reinforcement contingencies – now the former S+ signaled no reinforcer and the previous S- now indicated reinforcement availability.
T7025	26486-26488	PRP	denotes	We
T7027	26489-26493	RB	denotes	next
T7026	26494-26506	VBD	denotes	investigated
T7029	26507-26510	DT	denotes	the
T7030	26511-26523	NN	denotes	contribution
T7031	26524-26526	IN	denotes	of
T7032	26527-26535	NN	denotes	dopamine
T7033	26536-26540	NNS	denotes	D2Rs
T7034	26541-26543	IN	denotes	to
T7035	26544-26552	NN	denotes	reversal
T7036	26553-26561	NN	denotes	learning
T7037	26562-26570	NN	denotes	behavior
T7038	26571-26573	IN	denotes	by
T7039	26574-26583	VBG	denotes	inverting
T7040	26584-26587	DT	denotes	the
T7042	26588-26601	NN	denotes	reinforcement
T7041	26602-26615	NNS	denotes	contingencies
T7043	26616-26617	:	denotes	–
T7044	26618-26621	RB	denotes	now
T7045	26622-26625	DT	denotes	the
T7047	26626-26632	JJ	denotes	former
T7046	26633-26634	NN	denotes	S
T7048	26634-26635	SYM	denotes	+
T7028	26636-26644	VBD	denotes	signaled
T7049	26645-26647	DT	denotes	no
T7050	26648-26658	NN	denotes	reinforcer
T7051	26659-26662	CC	denotes	and
T7052	26663-26666	DT	denotes	the
T7054	26667-26675	JJ	denotes	previous
T7053	26676-26677	NN	denotes	S
T7056	26677-26678	SYM	denotes	-
T7057	26679-26682	RB	denotes	now
T7055	26683-26692	VBD	denotes	indicated
T7058	26693-26706	NN	denotes	reinforcement
T7059	26707-26719	NN	denotes	availability
T7060	26719-26720	.	denotes	.
T7061	26720-26850	sentence	denotes	This manipulation permits an evaluation of the ability to inhibit responses to previously reinforced discriminative stimuli [18].
T7062	26721-26725	DT	denotes	This
T7063	26726-26738	NN	denotes	manipulation
T7064	26739-26746	VBZ	denotes	permits
T7065	26747-26749	DT	denotes	an
T7066	26750-26760	NN	denotes	evaluation
T7067	26761-26763	IN	denotes	of
T7068	26764-26767	DT	denotes	the
T7069	26768-26775	NN	denotes	ability
T7070	26776-26778	TO	denotes	to
T7071	26779-26786	VB	denotes	inhibit
T7072	26787-26796	NNS	denotes	responses
T7073	26797-26799	IN	denotes	to
T7074	26800-26810	RB	denotes	previously
T7075	26811-26821	VBN	denotes	reinforced
T7077	26822-26836	JJ	denotes	discriminative
T7076	26837-26844	NNS	denotes	stimuli
T7078	26845-26846	-LRB-	denotes	[
T7079	26846-26848	CD	denotes	18
T7080	26848-26849	-RRB-	denotes	]
T7081	26849-26850	.	denotes	.
T7082	26850-26977	sentence	denotes	The number of trials necessary to establish 8 out of 10 accurate responses was our definition of successful reversal learning.
T7083	26851-26854	DT	denotes	The
T7084	26855-26861	NN	denotes	number
T7086	26862-26864	IN	denotes	of
T7087	26865-26871	NNS	denotes	trials
T7088	26872-26881	JJ	denotes	necessary
T7089	26882-26884	TO	denotes	to
T7090	26885-26894	VB	denotes	establish
T7091	26895-26896	CD	denotes	8
T7093	26897-26900	IN	denotes	out
T7094	26901-26903	IN	denotes	of
T7095	26904-26906	CD	denotes	10
T7096	26907-26915	JJ	denotes	accurate
T7092	26916-26925	NNS	denotes	responses
T7085	26926-26929	VBD	denotes	was
T7097	26930-26933	PRP$	denotes	our
T7098	26934-26944	NN	denotes	definition
T7099	26945-26947	IN	denotes	of
T7100	26948-26958	JJ	denotes	successful
T7102	26959-26967	NN	denotes	reversal
T7101	26968-26976	NN	denotes	learning
T7103	26976-26977	.	denotes	.
T7118	26979-26983	NN	denotes	Data
T7119	26984-26992	NN	denotes	analysis
T7120	26992-27252	sentence	denotes	The latency to retrieve a pellet from an empty dish, the latency to dig through a dish filled with unscented sand, and the number of errors of commission committed across the reversal sessions were analyzed with 2-way analyses of variance (genotype × trials).
T7121	26993-26996	DT	denotes	The
T7122	26997-27004	NN	denotes	latency
T7124	27005-27007	TO	denotes	to
T7125	27008-27016	VB	denotes	retrieve
T7126	27017-27018	DT	denotes	a
T7127	27019-27025	NN	denotes	pellet
T7128	27026-27030	IN	denotes	from
T7129	27031-27033	DT	denotes	an
T7131	27034-27039	JJ	denotes	empty
T7130	27040-27044	NN	denotes	dish
T7132	27044-27046	,	denotes	,
T7133	27046-27049	DT	denotes	the
T7134	27050-27057	NN	denotes	latency
T7135	27058-27060	TO	denotes	to
T7136	27061-27064	VB	denotes	dig
T7137	27065-27072	IN	denotes	through
T7138	27073-27074	DT	denotes	a
T7139	27075-27079	NN	denotes	dish
T7140	27080-27086	VBN	denotes	filled
T7141	27087-27091	IN	denotes	with
T7142	27092-27101	JJ	denotes	unscented
T7143	27102-27106	NN	denotes	sand
T7144	27106-27108	,	denotes	,
T7145	27108-27111	CC	denotes	and
T7146	27112-27115	DT	denotes	the
T7147	27116-27122	NN	denotes	number
T7148	27123-27125	IN	denotes	of
T7149	27126-27132	NNS	denotes	errors
T7150	27133-27135	IN	denotes	of
T7151	27136-27146	NN	denotes	commission
T7152	27147-27156	VBN	denotes	committed
T7153	27157-27163	IN	denotes	across
T7154	27164-27167	DT	denotes	the
T7156	27168-27176	NN	denotes	reversal
T7155	27177-27185	NNS	denotes	sessions
T7157	27186-27190	VBD	denotes	were
T7123	27191-27199	VBN	denotes	analyzed
T7158	27200-27204	IN	denotes	with
T7159	27205-27206	CD	denotes	2
T7161	27206-27207	HYPH	denotes	-
T7160	27207-27210	NN	denotes	way
T7162	27211-27219	NNS	denotes	analyses
T7163	27220-27222	IN	denotes	of
T7164	27223-27231	NN	denotes	variance
T7165	27232-27233	-LRB-	denotes	(
T7167	27233-27241	NN	denotes	genotype
T7168	27242-27243	SYM	denotes	×
T7166	27244-27250	NNS	denotes	trials
T7169	27250-27251	-RRB-	denotes	)
T7170	27251-27252	.	denotes	.
T7171	27252-27599	sentence	denotes	The number of trials necessary to attain criterion performance in odor discrimination (8 correct responses across 10 consecutive trials) and errors committed while learning the discrimination tasks were separated as individual testing phases (e.g. odor discrimination and reversal learning) and analyzed separately with unpaired 2-tailed t-tests.
T7172	27253-27256	DT	denotes	The
T7173	27257-27263	NN	denotes	number
T7175	27264-27266	IN	denotes	of
T7176	27267-27273	NNS	denotes	trials
T7177	27274-27283	JJ	denotes	necessary
T7178	27284-27286	TO	denotes	to
T7179	27287-27293	VB	denotes	attain
T7180	27294-27303	NN	denotes	criterion
T7181	27304-27315	NN	denotes	performance
T7182	27316-27318	IN	denotes	in
T7183	27319-27323	NN	denotes	odor
T7184	27324-27338	NN	denotes	discrimination
T7185	27339-27340	-LRB-	denotes	(
T7187	27340-27341	CD	denotes	8
T7188	27342-27349	JJ	denotes	correct
T7186	27350-27359	NNS	denotes	responses
T7189	27360-27366	IN	denotes	across
T7190	27367-27369	CD	denotes	10
T7192	27370-27381	JJ	denotes	consecutive
T7191	27382-27388	NNS	denotes	trials
T7193	27388-27389	-RRB-	denotes	)
T7194	27390-27393	CC	denotes	and
T7195	27394-27400	NNS	denotes	errors
T7196	27401-27410	VBN	denotes	committed
T7197	27411-27416	IN	denotes	while
T7198	27417-27425	VBG	denotes	learning
T7199	27426-27429	DT	denotes	the
T7201	27430-27444	NN	denotes	discrimination
T7200	27445-27450	NNS	denotes	tasks
T7202	27451-27455	VBD	denotes	were
T7174	27456-27465	VBN	denotes	separated
T7203	27466-27468	IN	denotes	as
T7204	27469-27479	JJ	denotes	individual
T7206	27480-27487	NN	denotes	testing
T7205	27488-27494	NNS	denotes	phases
T7207	27495-27496	-LRB-	denotes	(
T7209	27496-27500	FW	denotes	e.g.
T7210	27501-27505	NN	denotes	odor
T7208	27506-27520	NN	denotes	discrimination
T7211	27521-27524	CC	denotes	and
T7212	27525-27533	NN	denotes	reversal
T7213	27534-27542	NN	denotes	learning
T7214	27542-27543	-RRB-	denotes	)
T7215	27544-27547	CC	denotes	and
T7216	27548-27556	VBN	denotes	analyzed
T7217	27557-27567	RB	denotes	separately
T7218	27568-27572	IN	denotes	with
T7219	27573-27581	JJ	denotes	unpaired
T7221	27582-27583	CD	denotes	2
T7223	27583-27584	HYPH	denotes	-
T7222	27584-27590	JJ	denotes	tailed
T7224	27591-27592	NN	denotes	t
T7225	27592-27593	HYPH	denotes	-
T7220	27593-27598	NNS	denotes	tests
T7226	27598-27599	.	denotes	.
T7227	27599-27641	sentence	denotes	Significance was established at p < 0.05.
T7228	27600-27612	NN	denotes	Significance
T7230	27613-27616	VBD	denotes	was
T7229	27617-27628	VBN	denotes	established
T7231	27629-27631	IN	denotes	at
T7232	27632-27633	NN	denotes	p
T7233	27634-27635	SYM	denotes	<
T7234	27636-27640	CD	denotes	0.05
T7235	27640-27641	.	denotes	.
T7236	27641-27861	sentence	denotes	Errors committed during reversal trials were further categorically separated as errors of commission (failing to withhold responding to S-) and errors of omission (failing to dig in either dish after 3-min had expired).
T7237	27642-27648	NNS	denotes	Errors
T7239	27649-27658	VBN	denotes	committed
T7240	27659-27665	IN	denotes	during
T7241	27666-27674	NN	denotes	reversal
T7242	27675-27681	NNS	denotes	trials
T7243	27682-27686	VBD	denotes	were
T7244	27687-27694	RB	denotes	further
T7245	27695-27708	RB	denotes	categorically
T7238	27709-27718	VBN	denotes	separated
T7246	27719-27721	IN	denotes	as
T7247	27722-27728	NNS	denotes	errors
T7248	27729-27731	IN	denotes	of
T7249	27732-27742	NN	denotes	commission
T7250	27743-27744	-LRB-	denotes	(
T7251	27744-27751	VBG	denotes	failing
T7252	27752-27754	TO	denotes	to
T7253	27755-27763	VB	denotes	withhold
T7254	27764-27774	VBG	denotes	responding
T7255	27775-27777	IN	denotes	to
T7256	27778-27779	NN	denotes	S
T7257	27779-27780	SYM	denotes	-
T7258	27780-27781	-RRB-	denotes	)
T7259	27782-27785	CC	denotes	and
T7260	27786-27792	NNS	denotes	errors
T7261	27793-27795	IN	denotes	of
T7262	27796-27804	NN	denotes	omission
T7263	27805-27806	-LRB-	denotes	(
T7264	27806-27813	VBG	denotes	failing
T7265	27814-27816	TO	denotes	to
T7266	27817-27820	VB	denotes	dig
T7267	27821-27823	IN	denotes	in
T7268	27824-27830	DT	denotes	either
T7269	27831-27835	NN	denotes	dish
T7270	27836-27841	IN	denotes	after
T7272	27842-27843	CD	denotes	3
T7274	27843-27844	HYPH	denotes	-
T7273	27844-27847	NN	denotes	min
T7275	27848-27851	VBD	denotes	had
T7271	27852-27859	VBN	denotes	expired
T7276	27859-27860	-RRB-	denotes	)
T7277	27860-27861	.	denotes	.
T7278	27861-28035	sentence	denotes	Categorical errors and number of commission errors committed during the first reversal learning session were analyzed between groups with nonparametric Mann-Whitney U tests.
T7279	27862-27873	JJ	denotes	Categorical
T7280	27874-27880	NNS	denotes	errors
T7282	27881-27884	CC	denotes	and
T7283	27885-27891	NN	denotes	number
T7284	27892-27894	IN	denotes	of
T7285	27895-27905	NN	denotes	commission
T7286	27906-27912	NNS	denotes	errors
T7287	27913-27922	VBN	denotes	committed
T7288	27923-27929	IN	denotes	during
T7289	27930-27933	DT	denotes	the
T7291	27934-27939	JJ	denotes	first
T7292	27940-27948	NN	denotes	reversal
T7293	27949-27957	NN	denotes	learning
T7290	27958-27965	NN	denotes	session
T7294	27966-27970	VBD	denotes	were
T7281	27971-27979	VBN	denotes	analyzed
T7295	27980-27987	IN	denotes	between
T7296	27988-27994	NNS	denotes	groups
T7297	27995-27999	IN	denotes	with
T7298	28000-28013	JJ	denotes	nonparametric
T7300	28014-28018	NNP	denotes	Mann
T7302	28018-28019	HYPH	denotes	-
T7301	28019-28026	NNP	denotes	Whitney
T7303	28027-28028	NN	denotes	U
T7299	28029-28034	NNS	denotes	tests
T7304	28034-28035	.	denotes	.
R10	T235	T237	compound	odor,discrimination
R100	T333	T316	auxpass	been,identified
R1000	T1736	T1737	dep	that,have
R1001	T1737	T1734	relcl	have,effect
R1002	T1738	T1739	compound	locomotor,disruption
R1003	T1739	T1737	nsubj	disruption,have
R1004	T1740	T1739	acl	associated,disruption
R1005	T1741	T1740	prep	with,associated
R1006	T1742	T1743	amod	acute,blockade
R1007	T1743	T1741	pobj	blockade,with
R1008	T1744	T1743	compound	D2R,blockade
R1009	T1745	T1737	aux	can,have
R101	T335	T334	punct	", ",established
R1010	T1746	T1737	prep	on,have
R1011	T1747	T1748	compound	learning,performance
R1012	T1748	T1746	pobj	performance,on
R1013	T1749	T1737	prep	in,have
R1014	T1750	T1749	pobj	rodents,in
R1015	T1751	T1692	punct	.,utilized
R1016	T1753	T1754	prep	Besides,fails
R1017	T1755	T1756	poss	their,lack
R1018	T1756	T1753	pobj	lack,Besides
R1019	T1757	T1756	prep	of,lack
R102	T336	T337	det	an,involvement
R1020	T1758	T1759	compound	receptor,subtype
R1021	T1759	T1760	compound	subtype,specificity
R1022	T1760	T1757	pobj	specificity,of
R1023	T1761	T1754	punct	", ",fails
R1024	T1762	T1763	det	an,exposure
R1025	T1763	T1754	nsubj	exposure,fails
R1026	T1764	T1763	amod	acute,exposure
R1027	T1765	T1763	prep	to,exposure
R1028	T1766	T1767	advmod	commercially,available
R1029	T1767	T1768	amod	available,antagonists
R103	T337	T334	nsubjpass	involvement,established
R1030	T1768	T1765	pobj	antagonists,to
R1031	T1769	T1770	compound	D2,receptor
R1032	T1770	T1768	compound	receptor,antagonists
R1033	T1771	T1772	aux	to,block
R1034	T1772	T1754	xcomp	block,fails
R1035	T1773	T1772	advmod	completely,block
R1036	T1774	T1772	dobj	signaling,block
R1037	T1775	T1774	acl	mediated,signaling
R1038	T1776	T1775	advmod	solely,mediated
R1039	T1777	T1775	agent	by,mediated
R104	T338	T337	amod	explicit,involvement
R1040	T1778	T1777	pobj	D2Rs,by
R1041	T1779	T1754	punct	.,fails
R1042	T1781	T1782	advmod	Moreover,recapitulate
R1043	T1783	T1782	punct	", ",recapitulate
R1044	T1784	T1785	amod	acute,dosing
R1045	T1785	T1782	nsubj	dosing,recapitulate
R1046	T1786	T1782	aux	does,recapitulate
R1047	T1787	T1782	neg	not,recapitulate
R1048	T1788	T1789	det	the,deficits
R1049	T1789	T1782	dobj	deficits,recapitulate
R105	T339	T337	prep	of,involvement
R1050	T1790	T1789	amod	marked,deficits
R1051	T1791	T1789	compound	learning,deficits
R1052	T1792	T1789	acl	produced,deficits
R1053	T1793	T1792	prep	in,produced
R1054	T1794	T1793	pobj	rodents,in
R1055	T1795	T1796	punct	[,16
R1056	T1796	T1792	parataxis	16,produced
R1057	T1797	T1796	nummod	15,16
R1058	T1798	T1796	punct	",",16
R1059	T1799	T1796	punct	],16
R106	T340	T341	compound	D2,receptors
R1060	T1800	T1792	agent	by,produced
R1061	T1801	T1802	amod	chronic,exposure
R1062	T1802	T1800	pobj	exposure,by
R1063	T1803	T1802	prep	to,exposure
R1064	T1804	T1805	compound	dopamine,D2R
R1065	T1805	T1806	compound	D2R,antagonists
R1066	T1806	T1803	pobj	antagonists,to
R1067	T1818	T1819	compound	dopamine,D2R
R1068	T1807	T1808	punct	[,7
R1069	T1819	T1820	npadvmod	D2R,mediated
R107	T341	T339	pobj	receptors,of
R1070	T1808	T1792	parataxis	7,produced
R1071	T1820	T1822	amod	mediated,signaling
R1072	T1809	T1808	nummod	6,7
R1073	T1821	T1820	punct	-,mediated
R1074	T1822	T1817	pobj	signaling,of
R1075	T1810	T1808	punct	",",7
R1076	T1823	T1815	prep	on,influence
R1077	T1824	T1825	amod	reversal,learning
R1078	T1811	T1808	punct	],7
R1079	T1825	T1823	pobj	learning,on
R108	T342	T334	aux	has,established
R1080	T1826	T1816	advmod	also,is
R1081	T1827	T1828	advmod	poorly,understood
R1082	T1812	T1782	punct	.,recapitulate
R1083	T1828	T1816	acomp	understood,is
R1084	T1814	T1815	det	The,influence
R1085	T1829	T1816	punct	.,is
R1086	T1831	T1832	amod	Reversal,learning
R1087	T1832	T1833	nsubjpass	learning,conceptualized
R1088	T1815	T1816	nsubj	influence,is
R1089	T1834	T1833	aux	can,conceptualized
R109	T343	T334	neg	not,established
R1090	T1817	T1815	prep	of,influence
R1091	T1835	T1833	auxpass	be,conceptualized
R1092	T1836	T1833	prep	as,conceptualized
R1093	T1837	T1838	det	the,ability
R1094	T1924	T1925	det	the,antagonist
R1095	T1838	T1836	pobj	ability,as
R1096	T1839	T1840	aux	to,recognize
R1097	T1840	T1838	acl	recognize,ability
R1098	T1841	T1842	det	an,consequence
R1099	T1842	T1840	dobj	consequence,recognize
R11	T236	T235	punct	-,odor
R110	T344	T334	auxpass	been,established
R1100	T1925	T1923	pobj	antagonist,of
R1101	T1843	T1842	amod	unexpected,consequence
R1102	T1844	T1842	prep	to,consequence
R1103	T1926	T1927	compound	D2R,D3R
R1104	T1845	T1846	det	a,rule
R1105	T1846	T1844	pobj	rule,to
R1106	T1847	T1848	advmod	previously,established
R1107	T1927	T1925	compound	D3R,antagonist
R1108	T1848	T1846	amod	established,rule
R1109	T1849	T1850	amod	associative,learning
R111	T345	T334	advmod	clearly,established
R1110	T1928	T1927	punct	/,D3R
R1111	T1850	T1846	compound	learning,rule
R1112	T1851	T1840	cc	and,recognize
R1113	T1929	T1925	punct	", ",antagonist
R1114	T1852	T1853	advmod	then,alter
R1115	T1853	T1840	conj	alter,recognize
R1116	T1854	T1855	compound	response,strategies
R1117	T1855	T1853	dobj	strategies,alter
R1118	T1930	T1925	appos	sulpiride,antagonist
R1119	T1856	T1853	advmod	accordingly,alter
R112	T346	T334	punct	.,established
R1120	T1857	T1858	punct	[,18
R1121	T1931	T1922	punct	", ",impairs
R1122	T1858	T1853	parataxis	18,alter
R1123	T1859	T1858	nummod	17,18
R1124	T1860	T1858	punct	",",18
R1125	T1861	T1858	punct	],18
R1126	T1862	T1833	punct	.,conceptualized
R1127	T1932	T1933	amod	spatial,leaning
R1128	T1864	T1865	amod	Reversal,learning
R1129	T1865	T1866	nsubj	learning,serve
R113	T348	T349	aux	To,determine
R1130	T1933	T1922	dobj	leaning,impairs
R1131	T1867	T1865	prep	in,learning
R1132	T1868	T1867	pobj	rodents,in
R1133	T1934	T1933	compound	reversal,leaning
R1134	T1869	T1866	aux	can,serve
R1135	T1870	T1866	prep	as,serve
R1136	T1935	T1922	prep	in,impairs
R1137	T1871	T1872	det	an,index
R1138	T1872	T1870	pobj	index,as
R1139	T1873	T1872	prep	of,index
R114	T349	T350	advcl	determine,compared
R1140	T1936	T1935	pobj	mice,in
R1141	T1874	T1875	amod	learning,adaptability
R1142	T1875	T1873	pobj	adaptability,of
R1143	T1937	T1938	punct	[,20
R1144	T1876	T1875	cc	and,adaptability
R1145	T1877	T1875	conj	alertness,adaptability
R1146	T1878	T1879	dep	that,correlates
R1147	T1938	T1922	parataxis	20,impairs
R1148	T1879	T1872	relcl	correlates,index
R1149	T1880	T1879	prep	with,correlates
R115	T351	T352	mark	whether,contributes
R1150	T1881	T1882	amod	human,paradigms
R1151	T1939	T1938	punct	],20
R1152	T1882	T1880	pobj	paradigms,with
R1153	T1883	T1884	amod	attentional,shift
R1154	T1940	T1922	cc	and,impairs
R1155	T1884	T1882	compound	shift,paradigms
R1156	T1885	T1884	punct	-,shift
R1157	T1886	T1887	punct	[,18
R1158	T1941	T1942	aux	has,shown
R1159	T1887	T1872	parataxis	18,index
R116	T352	T349	ccomp	contributes,determine
R1160	T1888	T1887	nummod	17,18
R1161	T1942	T1922	conj	shown,impairs
R1162	T1889	T1887	punct	",",18
R1163	T1890	T1887	punct	],18
R1164	T1943	T1942	advmod	also,shown
R1165	T1891	T1866	punct	.,serve
R1166	T1893	T1894	advmod	Additionally,demonstrated
R1167	T1944	T1942	auxpass	been,shown
R1168	T1895	T1894	punct	", ",demonstrated
R1169	T1945	T1946	aux	to,impair
R117	T353	T354	compound	dopamine,D2
R1170	T1896	T1897	det	a,report
R1171	T1897	T1894	nsubj	report,demonstrated
R1172	T1898	T1897	amod	previous,report
R1173	T1946	T1942	xcomp	impair,shown
R1174	T1899	T1900	mark	that,shown
R1175	T1900	T1894	ccomp	shown,demonstrated
R1176	T1947	T1946	dobj	attention,impair
R1177	T1901	T1902	amod	excitotoxic,lesions
R1178	T1902	T1900	nsubjpass	lesions,shown
R1179	T1903	T1902	prep	of,lesions
R118	T354	T355	compound	D2,receptor
R1180	T1948	T1947	cc	and,attention
R1181	T1904	T1905	amod	terminal,field
R1182	T1905	T1906	compound	field,targets
R1183	T1906	T1903	pobj	targets,of
R1184	T1949	T1950	det	the,performances
R1185	T1907	T1906	prep	of,targets
R1186	T1908	T1909	amod	mesocortical,dopamine
R1187	T1950	T1947	conj	performances,attention
R1188	T1909	T1907	pobj	dopamine,of
R1189	T1910	T1900	aux	have,shown
R119	T355	T356	npadvmod	receptor,mediated
R1190	T1911	T1900	auxpass	been,shown
R1191	T1951	T1950	amod	cognitive,performances
R1192	T1912	T1913	aux	to,disrupt
R1193	T1913	T1900	xcomp	disrupt,shown
R1194	T1914	T1915	compound	reversal,learning
R1195	T1952	T1950	prep	of,performances
R1196	T1915	T1913	dobj	learning,disrupt
R1197	T1916	T1917	punct	[,19
R1198	T1953	T1954	amod	healthy,volunteers
R1199	T1917	T1913	parataxis	19,disrupt
R12	T237	T233	dobj	discrimination,mediate
R120	T356	T358	amod	mediated,signaling
R1200	T1918	T1917	punct	],19
R1201	T1919	T1894	punct	.,demonstrated
R1202	T1954	T1952	pobj	volunteers,of
R1203	T1921	T1922	nsubj	Administration,impairs
R1204	T1955	T1954	amod	human,volunteers
R1205	T1923	T1921	prep	of,Administration
R1206	T1956	T1957	punct	[,21
R1207	T1957	T1942	parataxis	21,shown
R1208	T1958	T1957	punct	],21
R1209	T1959	T1922	punct	.,impairs
R121	T357	T356	punct	-,mediated
R1210	T1961	T1962	advmod	Moreover,reported
R1211	T2030	T2027	compound	reversal,learning
R1212	T1963	T1964	det	an,relationship
R1213	T2031	T2017	prep	in,contribution
R1214	T2032	T2033	amod	adult,mice
R1215	T2033	T2031	pobj	mice,in
R1216	T1964	T1962	nsubjpass	relationship,reported
R1217	T2034	T2011	punct	", ",compared
R1218	T2035	T2011	nsubj	we,compared
R1219	T2036	T2011	dobj	mice,compared
R122	T358	T352	nsubj	signaling,contributes
R1220	T1965	T1964	amod	inverse,relationship
R1221	T2037	T2038	punct	[,23
R1222	T2038	T2036	parataxis	23,mice
R1223	T2039	T2038	punct	],23
R1224	T1966	T1964	prep	between,relationship
R1225	T2040	T2041	dep	that,developed
R1226	T2041	T2036	relcl	developed,mice
R1227	T2042	T2041	aux	had,developed
R1228	T2043	T2041	prep	in,developed
R1229	T1967	T1968	amod	lower,levels
R123	T359	T352	prep	to,contributes
R1230	T2044	T2045	det	the,absence
R1231	T2045	T2043	pobj	absence,in
R1232	T2046	T2045	amod	complete,absence
R1233	T1968	T1966	pobj	levels,between
R1234	T2047	T2045	prep	of,absence
R1235	T2048	T2049	det	all,receptors
R1236	T2049	T2047	pobj	receptors,of
R1237	T1969	T1970	compound	dopamine,D2R
R1238	T2050	T2049	amod	functional,receptors
R1239	T2051	T2052	compound	dopamine,D2
R124	T360	T361	amod	associative,learning
R1240	T1970	T1968	compound	D2R,levels
R1241	T2052	T2049	compound	D2,receptors
R1242	T2053	T2054	punct	(,D2R
R1243	T2054	T2049	parataxis	D2R,receptors
R1244	T1971	T1968	cc	and,levels
R1245	T2055	T2054	punct	-,D2R
R1246	T2056	T2054	punct	/,D2R
R1247	T1972	T1973	amod	compulsive,behavior
R1248	T2057	T2054	punct	-,D2R
R1249	T2058	T2054	punct	),D2R
R125	T361	T359	pobj	learning,to
R1250	T2059	T2011	prep	to,compared
R1251	T1973	T1968	conj	behavior,levels
R1252	T2060	T2061	amod	wild,type
R1253	T2061	T2063	compound	type,littermates
R1254	T2062	T2061	punct	-,type
R1255	T1974	T1964	prep	in,relationship
R1256	T2063	T2059	pobj	littermates,to
R1257	T2064	T2065	punct	(,D2R
R1258	T2065	T2063	parataxis	D2R,littermates
R1259	T1975	T1976	amod	human,subjects
R126	T362	T360	cc	and,associative
R1260	T2066	T2065	punct	+,D2R
R1261	T2067	T2065	punct	/,D2R
R1262	T2068	T2065	punct	+,D2R
R1263	T1976	T1974	pobj	subjects,in
R1264	T2069	T2065	punct	),D2R
R1265	T2070	T2011	prep	in,compared
R1266	T1977	T1962	aux	has,reported
R1267	T2071	T2072	det	a,procedure
R1268	T1978	T1962	auxpass	been,reported
R1269	T2072	T2070	pobj	procedure,in
R127	T363	T360	conj	reversal,associative
R1270	T2073	T2072	nmod	go,procedure
R1271	T1979	T1980	punct	[,22
R1272	T2074	T2073	punct	/,go
R1273	T2075	T2076	det	no,go
R1274	T2076	T2073	appos	go,go
R1275	T1980	T1962	parataxis	22,reported
R1276	T2077	T2076	punct	-,go
R1277	T2078	T2072	nmod	operant,procedure
R1278	T2079	T2078	amod	learning,operant
R1279	T2080	T2081	dep	that,measures
R128	T364	T350	punct	", ",compared
R1280	T2081	T2072	relcl	measures,procedure
R1281	T1981	T1980	punct	],22
R1282	T2082	T2083	amod	primary,reinforcement
R1283	T2083	T2081	dobj	reinforcement,measures
R1284	T2084	T2083	punct	", ",reinforcement
R1285	T1982	T1962	punct	.,reported
R1286	T2085	T2086	amod	sensory,processing
R1287	T2086	T2083	conj	processing,reinforcement
R1288	T1984	T1985	advcl	Taken,suggest
R1289	T2087	T2086	punct	", ",processing
R129	T365	T350	nsubj	we,compared
R1290	T2088	T2086	cc	and,processing
R1291	T2089	T2090	compound	reversal,learning
R1292	T1986	T1984	advmod	together,Taken
R1293	T2090	T2086	conj	learning,processing
R1294	T2091	T2092	punct	[,17
R1295	T2092	T2081	parataxis	17,measures
R1296	T2093	T2094	punct	-,19
R1297	T1987	T1988	det	these,findings
R1298	T2094	T2092	prep	19,17
R1299	T2095	T2092	punct	],17
R13	T238	T237	cc	and,discrimination
R130	T366	T367	compound	C57Bl,6J
R1300	T2096	T2011	punct	.,compared
R1301	T1988	T1985	nsubj	findings,suggest
R1302	T2098	T2099	advmod	Here,report
R1303	T1989	T1990	mark	that,play
R1304	T2100	T2099	nsubj	we,report
R1305	T2101	T2102	mark	that,be
R1306	T1990	T1985	ccomp	play,suggest
R1307	T2102	T2099	ccomp	be,report
R1308	T2103	T2104	compound	dopamine,D2R
R1309	T2104	T2105	npadvmod	D2R,mediated
R131	T367	T369	compound	6J,mice
R1310	T1991	T1992	npadvmod	D2R,mediated
R1311	T2105	T2107	amod	mediated,signaling
R1312	T2106	T2105	punct	-,mediated
R1313	T2107	T2102	nsubj	signaling,be
R1314	T1992	T1994	amod	mediated,signaling
R1315	T2108	T2102	aux	must,be
R1316	T2109	T2102	acomp	intact,be
R1317	T2110	T2111	mark	if,is
R1318	T1993	T1992	punct	-,mediated
R1319	T2111	T2102	advcl	is,be
R132	T368	T367	punct	/,6J
R1320	T2112	T2113	det	a,mouse
R1321	T1994	T1990	nsubj	signaling,play
R1322	T2113	T2111	nsubj	mouse,is
R1323	T2114	T2115	aux	to,learn
R1324	T2115	T2111	xcomp	learn,is
R1325	T1995	T1990	aux	could,play
R1326	T2116	T2115	advmod	efficiently,learn
R1327	T2117	T2118	aux	to,associate
R1328	T2118	T2115	xcomp	associate,learn
R1329	T2119	T2120	det	a,reinforcer
R133	T369	T350	dobj	mice,compared
R1330	T2120	T2118	dobj	reinforcer,associate
R1331	T1996	T1997	det	a,role
R1332	T2121	T2120	compound	food,reinforcer
R1333	T2122	T2118	prep	with,associate
R1334	T2123	T2124	det	a,odor
R1335	T2124	T2122	pobj	odor,with
R1336	T1997	T1990	dobj	role,play
R1337	T2125	T2124	amod	specific,odor
R1338	T2126	T2118	cc	and,associate
R1339	T1998	T1997	amod	critical,role
R134	T370	T371	dep	that,lack
R1340	T2127	T2128	advmod	then,disengage
R1341	T2128	T2118	conj	disengage,associate
R1342	T2129	T2128	advmod	adaptively,disengage
R1343	T2130	T2131	amod	inappropriate,strategies
R1344	T1999	T1990	prep	in,play
R1345	T2131	T2128	dobj	strategies,disengage
R1346	T2132	T2131	amod	behavioral,strategies
R1347	T2000	T2001	amod	reversal,learning
R1348	T2133	T2128	prep	following,disengage
R1349	T2134	T2135	det	the,reversal
R135	T371	T369	relcl	lack,mice
R1350	T2001	T1999	pobj	learning,in
R1351	T2002	T1985	cc	but,suggest
R1352	T2135	T2133	pobj	reversal,following
R1353	T2003	T1985	conj	are,suggest
R1354	T2136	T2135	prep	of,reversal
R1355	T2137	T2138	compound	reinforcement,contingencies
R1356	T2138	T2136	pobj	contingencies,of
R1357	T2004	T2003	acomp	insufficient,are
R1358	T2139	T2099	punct	.,report
R1359	T2005	T2006	aux	to,prove
R136	T372	T371	advmod	completely,lack
R1360	T2006	T2004	xcomp	prove,insufficient
R1361	T2007	T2006	dobj	it,prove
R1362	T2008	T1985	punct	.,suggest
R1363	T2010	T2011	prep	In,compared
R1364	T2012	T2013	det	an,effort
R1365	T2013	T2010	pobj	effort,In
R1366	T2014	T2015	aux	to,establish
R1367	T2015	T2013	acl	establish,effort
R1368	T2016	T2017	det	the,contribution
R1369	T2017	T2015	dobj	contribution,establish
R137	T373	T374	amod	functional,receptors
R1370	T2018	T2017	prep	of,contribution
R1371	T2019	T2020	compound	dopamine,receptor
R1372	T2020	T2022	npadvmod	receptor,mediated
R1373	T2021	T2020	compound	D2,receptor
R1374	T2022	T2024	amod	mediated,signaling
R1375	T2023	T2022	punct	-,mediated
R1376	T2024	T2018	pobj	signaling,of
R1377	T2025	T2017	prep	to,contribution
R1378	T2026	T2027	amod	associative,learning
R1379	T2027	T2025	pobj	learning,to
R138	T374	T371	dobj	receptors,lack
R1380	T2028	T2026	cc	and,associative
R1381	T2029	T2026	conj	non-spatial,associative
R1382	T2198	T2199	preconj	Both,type
R1383	T2199	T2202	nmod	type,mice
R1384	T2200	T2199	amod	wild,type
R1385	T2201	T2199	punct	-,type
R1386	T2202	T2206	nsubj	mice,learn
R1387	T2203	T2199	cc	and,type
R1388	T2204	T2205	npadvmod	D2R,deficient
R1389	T2205	T2199	conj	deficient,type
R139	T375	T376	compound	dopamine,D2
R1390	T2207	T2208	compound	operant,behaviors
R1391	T2208	T2206	dobj	behaviors,learn
R1392	T2209	T2210	advmod	equally,well
R1393	T2210	T2206	advmod	well,learn
R1394	T2212	T2213	advmod	Mildly,deprived
R1395	T2213	T2216	amod	deprived,mice
R1396	T2214	T2213	npadvmod	food,deprived
R1397	T2215	T2213	punct	-,deprived
R1398	T2216	T2226	nsubj	mice,learned
R1399	T2217	T2216	nmod	D2R,mice
R14	T239	T240	amod	reversal,learning
R140	T376	T374	compound	D2,receptors
R1400	T2218	T2217	punct	+,D2R
R1401	T2219	T2217	punct	/,D2R
R1402	T2220	T2217	punct	+,D2R
R1403	T2221	T2217	cc	and,D2R
R1404	T2222	T2217	conj	D2R,D2R
R1405	T2223	T2222	punct	-,D2R
R1406	T2224	T2222	punct	/,D2R
R1407	T2225	T2222	punct	-,D2R
R1408	T2227	T2226	advmod	readily,learned
R1409	T2228	T2229	aux	to,locate
R141	T377	T350	prep	to,compared
R1410	T2229	T2226	xcomp	locate,learned
R1411	T2230	T2229	cc	and,locate
R1412	T2231	T2229	conj	consume,locate
R1413	T2232	T2233	compound	food,pellets
R1414	T2233	T2231	dobj	pellets,consume
R1415	T2234	T2231	prep	during,consume
R1416	T2235	T2236	det	both,sessions
R1417	T2236	T2234	pobj	sessions,during
R1418	T2237	T2236	compound	training,sessions
R1419	T2238	T2226	punct	.,learned
R142	T378	T379	amod	wild,type
R1420	T2240	T2241	nsubj	Figure,depicts
R1421	T2242	T2240	nummod	1,Figure
R1422	T2243	T2244	det	the,latency
R1423	T2244	T2241	dobj	latency,depicts
R1424	T2245	T2246	mark	for,ambulate
R1425	T2246	T2244	advcl	ambulate,latency
R1426	T2247	T2248	det	both,genotypes
R1427	T2248	T2246	nsubj	genotypes,ambulate
R1428	T2249	T2246	aux	to,ambulate
R1429	T2250	T2246	prep	to,ambulate
R143	T379	T381	compound	type,mice
R1430	T2251	T2252	det	a,dish
R1431	T2252	T2250	pobj	dish,to
R1432	T2253	T2254	aux	to,retrieve
R1433	T2254	T2246	advcl	retrieve,ambulate
R1434	T2255	T2256	det	an,pellet
R1435	T2256	T2254	dobj	pellet,retrieve
R1436	T2257	T2256	amod	unhidden,pellet
R1437	T2258	T2256	compound	food,pellet
R1438	T2259	T2241	punct	.,depicts
R1439	T2261	T2262	expl	There,were
R144	T380	T379	punct	-,type
R1440	T2263	T2264	det	no,differences
R1441	T2264	T2262	attr	differences,were
R1442	T2265	T2264	prep	between,differences
R1443	T2266	T2265	pobj	genotypes,between
R1444	T2267	T2268	aux	to,retrieve
R1445	T2268	T2262	advcl	retrieve,were
R1446	T2269	T2270	det	the,reinforcers
R1447	T2270	T2268	dobj	reinforcers,retrieve
R1448	T2271	T2272	punct	(,0.65
R1449	T2272	T2270	parataxis	0.65,reinforcers
R145	T381	T377	pobj	mice,to
R1450	T2273	T2274	nsubj	F1,0.2
R1451	T2274	T2272	ccomp	0.2,0.65
R1452	T2275	T2273	punct	",",F1
R1453	T2276	T2273	nummod	59,F1
R1454	T2277	T2274	punct	=,0.2
R1455	T2278	T2272	punct	", ",0.65
R1456	T2279	T2272	nsubj	p,0.65
R1457	T2280	T2272	punct	>,0.65
R1458	T2281	T2272	punct	),0.65
R1459	T2282	T2262	punct	", ",were
R146	T382	T350	prep	with,compared
R1460	T2283	T2262	cc	and,were
R1461	T2284	T2285	det	both,groups
R1462	T2285	T2286	nsubj	groups,decreased
R1463	T2286	T2262	conj	decreased,were
R1464	T2287	T2286	advmod	significantly,decreased
R1465	T2288	T2289	det	the,amount
R1466	T2289	T2286	dobj	amount,decreased
R1467	T2290	T2289	prep	of,amount
R1468	T2291	T2290	pobj	time,of
R1469	T2292	T2289	amod	necessary,amount
R147	T383	T382	pobj	respect,with
R1470	T2293	T2294	aux	to,perform
R1471	T2294	T2292	xcomp	perform,necessary
R1472	T2295	T2296	det	this,task
R1473	T2296	T2294	dobj	task,perform
R1474	T2297	T2286	prep	along,decreased
R1475	T2298	T2299	amod	successive,trials
R1476	T2299	T2297	pobj	trials,along
R1477	T2300	T2301	punct	(,0.001
R1478	T2301	T2299	parataxis	0.001,trials
R1479	T2302	T2303	nsubj	F4,5.74
R148	T384	T383	prep	to,respect
R1480	T2303	T2301	ccomp	5.74,0.001
R1481	T2304	T2302	punct	",",F4
R1482	T2305	T2302	nummod	59,F4
R1483	T2306	T2303	punct	=,5.74
R1484	T2307	T2301	punct	", ",0.001
R1485	T2308	T2301	nsubj	p,0.001
R1486	T2309	T2301	punct	<,0.001
R1487	T2310	T2301	punct	),0.001
R1488	T2311	T2286	punct	.,decreased
R1489	T2313	T2314	nsubj	Figure,depicts
R149	T385	T386	poss	their,ability
R1490	T2315	T2313	nummod	2,Figure
R1491	T2316	T2317	det	the,latency
R1492	T2317	T2314	dobj	latency,depicts
R1493	T2318	T2319	aux	to,dig
R1494	T2319	T2317	advcl	dig,latency
R1495	T2320	T2319	prep	for,dig
R1496	T2321	T2322	det	the,pellet
R1497	T2322	T2320	pobj	pellet,for
R1498	T2323	T2322	compound	food,pellet
R1499	T2324	T2322	acl	buried,pellet
R15	T240	T237	conj	learning,discrimination
R150	T386	T384	pobj	ability,to
R1500	T2325	T2324	prep	in,buried
R1501	T2326	T2327	det	a,dish
R1502	T2327	T2325	pobj	dish,in
R1503	T2328	T2327	amod	single,dish
R1504	T2329	T2327	acl	filled,dish
R1505	T2330	T2329	prep	with,filled
R1506	T2331	T2332	amod	unscented,sand
R1507	T2332	T2330	pobj	sand,with
R1508	T2333	T2314	punct	.,depicts
R1509	T2335	T2336	det	No,differences
R151	T387	T388	aux	to,attach
R1510	T2336	T2338	nsubjpass	differences,found
R1511	T2337	T2336	compound	genotype,differences
R1512	T2339	T2338	auxpass	were,found
R1513	T2340	T2338	prep	in,found
R1514	T2341	T2342	det	the,ability
R1515	T2342	T2340	pobj	ability,in
R1516	T2343	T2344	aux	to,dig
R1517	T2344	T2342	acl	dig,ability
R1518	T2345	T2344	prep	through,dig
R1519	T2346	T2347	amod	unscented,sand
R152	T388	T386	acl	attach,ability
R1520	T2347	T2345	pobj	sand,through
R1521	T2348	T2344	prep	for,dig
R1522	T2349	T2350	det	a,pellet
R1523	T2350	T2348	pobj	pellet,for
R1524	T2351	T2350	amod	hidden,pellet
R1525	T2352	T2350	compound	food,pellet
R1526	T2353	T2354	punct	(,0.27
R1527	T2354	T2338	parataxis	0.27,found
R1528	T2355	T2356	nsubj	F1,1.26
R1529	T2356	T2354	ccomp	1.26,0.27
R153	T389	T390	amod	appropriate,salience
R1530	T2357	T2355	punct	",",F1
R1531	T2358	T2355	nummod	128,F1
R1532	T2359	T2356	punct	=,1.26
R1533	T2360	T2354	punct	", ",0.27
R1534	T2361	T2354	nsubj	p,0.27
R1535	T2362	T2354	punct	>,0.27
R1536	T2363	T2354	punct	),0.27
R1537	T2364	T2338	punct	.,found
R1538	T2413	T2414	amod	Wild,type
R1539	T2414	T2416	compound	type,mice
R154	T390	T388	dobj	salience,attach
R1540	T2415	T2414	punct	-,type
R1541	T2416	T2417	nsubj	mice,outperform
R1542	T2418	T2419	nmod	D2R,mice
R1543	T2419	T2417	dobj	mice,outperform
R1544	T2420	T2418	punct	-,D2R
R1545	T2421	T2418	punct	/,D2R
R1546	T2422	T2418	punct	-,D2R
R1547	T2423	T2417	prep	in,outperform
R1548	T2424	T2425	det	an,task
R1549	T2425	T2423	pobj	task,in
R155	T391	T388	prep	to,attach
R1550	T2426	T2427	npadvmod	odor,driven
R1551	T2427	T2425	amod	driven,task
R1552	T2428	T2427	punct	-,driven
R1553	T2429	T2427	punct	", ",driven
R1554	T2430	T2431	compound	stimulus,discrimination
R1555	T2431	T2427	conj	discrimination,driven
R1556	T2432	T2431	punct	-,discrimination
R1557	T2433	T2425	punct	", ",task
R1558	T2434	T2425	compound	operant,task
R1559	T2436	T2437	aux	To,master
R156	T392	T393	amod	external,stimuli
R1560	T2437	T2438	advcl	master,required
R1561	T2439	T2440	det	the,task
R1562	T2440	T2437	dobj	task,master
R1563	T2441	T2442	npadvmod	odor,driven
R1564	T2442	T2440	amod	driven,task
R1565	T2443	T2442	punct	-,driven
R1566	T2444	T2445	compound	stimulus,discrimination
R1567	T2445	T2440	compound	discrimination,task
R1568	T2446	T2438	punct	", ",required
R1569	T2447	T2448	nmod	D2R,mice
R157	T393	T391	pobj	stimuli,to
R1570	T2448	T2438	nsubj	mice,required
R1571	T2449	T2447	punct	-,D2R
R1572	T2450	T2447	punct	/,D2R
R1573	T2451	T2447	punct	-,D2R
R1574	T2452	T2453	advmod	significantly,more
R1575	T2453	T2454	amod	more,trials
R1576	T2454	T2438	dobj	trials,required
R1577	T2455	T2456	punct	(,Fig.
R1578	T2456	T2438	parataxis	Fig.,required
R1579	T2457	T2456	nummod	3A,Fig.
R158	T394	T395	punct	(,discrimination
R1580	T2458	T2456	punct	: ,Fig.
R1581	T2459	T2460	nsubj	t,2.20
R1582	T2460	T2456	ccomp	2.20,Fig.
R1583	T2461	T2459	punct	(,t
R1584	T2462	T2459	nummod	14,t
R1585	T2463	T2459	punct	),t
R1586	T2464	T2460	punct	=,2.20
R1587	T2465	T2456	punct	;,Fig.
R1588	T2466	T2467	nsubj	p,0.05
R1589	T2467	T2456	ccomp	0.05,Fig.
R159	T395	T388	parataxis	discrimination,attach
R1590	T2468	T2467	punct	<,0.05
R1591	T2469	T2456	punct	),Fig.
R1592	T2470	T2438	cc	and,required
R1593	T2471	T2438	conj	committed,required
R1594	T2472	T2473	amod	more,errors
R1595	T2473	T2471	dobj	errors,committed
R1596	T2474	T2475	punct	(,Fig.
R1597	T2475	T2473	parataxis	Fig.,errors
R1598	T2476	T2475	nummod	3B,Fig.
R1599	T2477	T2475	punct	: ,Fig.
R16	T241	T233	prep	in,mediate
R160	T396	T395	compound	stimulus,discrimination
R1600	T2478	T2479	nsubj	t,2.92
R1601	T2479	T2475	ccomp	2.92,Fig.
R1602	T2480	T2478	punct	(,t
R1603	T2481	T2478	nummod	14,t
R1604	T2482	T2478	punct	),t
R1605	T2483	T2479	punct	=,2.92
R1606	T2484	T2475	punct	;,Fig.
R1607	T2485	T2486	nsubj	p,0.05
R1608	T2486	T2475	ccomp	0.05,Fig.
R1609	T2487	T2486	punct	<,0.05
R161	T397	T395	punct	),discrimination
R1610	T2488	T2475	punct	),Fig.
R1611	T2489	T2473	prep	than,errors
R1612	T2490	T2491	nmod	D2R,mice
R1613	T2491	T2489	pobj	mice,than
R1614	T2492	T2490	punct	+,D2R
R1615	T2493	T2490	punct	/,D2R
R1616	T2494	T2490	punct	+,D2R
R1617	T2495	T2496	aux	to,learn
R1618	T2496	T2438	advcl	learn,required
R1619	T2497	T2498	aux	to,associate
R162	T398	T388	cc	and,attach
R1620	T2498	T2496	xcomp	associate,learn
R1621	T2499	T2500	det	a,odor
R1622	T2500	T2498	dobj	odor,associate
R1623	T2501	T2500	amod	specific,odor
R1624	T2502	T2498	prep	with,associate
R1625	T2503	T2504	det	the,presence
R1626	T2504	T2502	pobj	presence,with
R1627	T2505	T2504	cc	or,presence
R1628	T2506	T2504	conj	absence,presence
R1629	T2507	T2504	prep	of,presence
R163	T399	T388	conj	disengage,attach
R1630	T2508	T2509	det	the,reinforcer
R1631	T2509	T2507	pobj	reinforcer,of
R1632	T2510	T2509	compound	food,reinforcer
R1633	T2511	T2438	punct	.,required
R1634	T2513	T2514	advmod	However,learn
R1635	T2515	T2514	punct	", ",learn
R1636	T2516	T2517	det	both,genotypes
R1637	T2517	T2514	nsubj	genotypes,learn
R1638	T2518	T2514	aux	did,learn
R1639	T2519	T2520	det	the,task
R164	T400	T399	prep	from,disengage
R1640	T2520	T2514	dobj	task,learn
R1641	T2521	T2514	cc	and,learn
R1642	T2522	T2523	advmod	eventually,maintained
R1643	T2523	T2514	conj	maintained,learn
R1644	T2524	T2525	amod	accurate,discrimination
R1645	T2525	T2523	dobj	discrimination,maintained
R1646	T2526	T2523	prep	for,maintained
R1647	T2527	T2528	det	a,minimum
R1648	T2528	T2526	pobj	minimum,for
R1649	T2529	T2528	prep	of,minimum
R165	T401	T402	amod	inappropriate,strategies
R1650	T2530	T2531	nummod	8,responses
R1651	T2531	T2529	pobj	responses,of
R1652	T2532	T2531	amod	correct,responses
R1653	T2533	T2531	prep	out,responses
R1654	T2534	T2533	prep	of,out
R1655	T2535	T2536	nummod	10,trials
R1656	T2536	T2534	pobj	trials,of
R1657	T2537	T2514	punct	.,learn
R1658	T2709	T2710	nsubj	Mice,engage
R1659	T2711	T2709	acl	lacking,Mice
R166	T402	T400	pobj	strategies,from
R1660	T2712	T2713	compound	dopamine,D2
R1661	T2713	T2714	compound	D2,receptors
R1662	T2714	T2711	dobj	receptors,lacking
R1663	T2715	T2710	prep	in,engage
R1664	T2716	T2717	amod	unreinforced,behavior
R1665	T2717	T2715	pobj	behavior,in
R1666	T2718	T2710	prep	in,engage
R1667	T2719	T2720	det	a,manner
R1668	T2720	T2718	pobj	manner,in
R1669	T2721	T2720	amod	perseverative,manner
R167	T403	T402	amod	behavioral,strategies
R1670	T2722	T2710	prep	following,engage
R1671	T2723	T2722	pobj	reversal,following
R1672	T2724	T2723	prep	of,reversal
R1673	T2725	T2726	compound	reinforcement,contingencies
R1674	T2726	T2724	pobj	contingencies,of
R1675	T2728	T2729	nmod	D2R,mice
R1676	T2729	T2733	nsubj	mice,failed
R1677	T2730	T2728	punct	-,D2R
R1678	T2731	T2728	punct	/,D2R
R1679	T2732	T2728	punct	-,D2R
R168	T404	T405	advmod	when,change
R1680	T2734	T2733	advmod	repeatedly,failed
R1681	T2735	T2736	aux	to,inhibit
R1682	T2736	T2733	xcomp	inhibit,failed
R1683	T2737	T2738	advmod	previously,established
R1684	T2738	T2739	amod	established,contingencies
R1685	T2739	T2736	dobj	contingencies,inhibit
R1686	T2740	T2739	amod	learning,contingencies
R1687	T2741	T2736	prep	during,inhibit
R1688	T2742	T2743	amod	reversal,trials
R1689	T2743	T2741	pobj	trials,during
R169	T405	T399	advcl	change,disengage
R1690	T2744	T2745	punct	(,Fig.
R1691	T2745	T2736	parataxis	Fig.,inhibit
R1692	T2746	T2745	nummod	4A,Fig.
R1693	T2747	T2745	punct	: ,Fig.
R1694	T2748	T2749	nsubj	t,3.54
R1695	T2749	T2745	ccomp	3.54,Fig.
R1696	T2750	T2748	punct	(,t
R1697	T2751	T2748	nummod	14,t
R1698	T2752	T2748	punct	),t
R1699	T2753	T2749	punct	=,3.54
R17	T242	T243	nmod	C57BL,mice
R170	T406	T407	compound	reinforcement,contingencies
R1700	T2754	T2745	punct	;,Fig.
R1701	T2755	T2756	nsubj	p,0.01
R1702	T2756	T2745	ccomp	0.01,Fig.
R1703	T2757	T2756	punct	<,0.01
R1704	T2758	T2745	punct	),Fig.
R1705	T2759	T2733	cc	and,failed
R1706	T2760	T2733	conj	committed,failed
R1707	T2761	T2762	advmod	significantly,more
R1708	T2762	T2763	amod	more,errors
R1709	T2763	T2760	dobj	errors,committed
R171	T407	T405	nsubj	contingencies,change
R1710	T2764	T2763	compound	reversal,errors
R1711	T2765	T2763	prep	than,errors
R1712	T2766	T2767	nmod	D2R,mice
R1713	T2767	T2765	pobj	mice,than
R1714	T2768	T2766	punct	+,D2R
R1715	T2769	T2766	punct	/,D2R
R1716	T2770	T2766	punct	+,D2R
R1717	T2771	T2772	punct	(,Fig.
R1718	T2772	T2760	parataxis	Fig.,committed
R1719	T2773	T2772	nummod	4B,Fig.
R172	T408	T409	punct	(,learning
R1720	T2774	T2772	punct	: ,Fig.
R1721	T2775	T2776	nsubj	t,3.18
R1722	T2776	T2772	ccomp	3.18,Fig.
R1723	T2777	T2775	punct	(,t
R1724	T2778	T2775	nummod	14,t
R1725	T2779	T2775	punct	),t
R1726	T2780	T2776	punct	=,3.18
R1727	T2781	T2772	punct	;,Fig.
R1728	T2782	T2783	nsubj	p,0.01
R1729	T2783	T2772	ccomp	0.01,Fig.
R173	T409	T399	parataxis	learning,disengage
R1730	T2784	T2783	punct	<,0.01
R1731	T2785	T2772	punct	),Fig.
R1732	T2786	T2733	punct	.,failed
R1733	T2788	T2789	amod	Categorical,division
R1734	T2789	T2790	nsubj	division,revealed
R1735	T2791	T2789	prep	of,division
R1736	T2792	T2793	compound	reversal,errors
R1737	T2793	T2791	pobj	errors,of
R1738	T2794	T2795	punct	(,Ferry
R1739	T2795	T2789	meta	Ferry,division
R174	T410	T409	advmod	e.g.,learning
R1740	T2796	T2795	nmod	et,Ferry
R1741	T2797	T2795	nmod	al.,Ferry
R1742	T2798	T2795	punct	", ",Ferry
R1743	T2799	T2795	nummod	2000,Ferry
R1744	T2800	T2795	punct	),Ferry
R1745	T2801	T2789	punct	–,division
R1746	T2802	T2789	acl	digging,division
R1747	T2803	T2802	prep	in,digging
R1748	T2804	T2805	det	the,dish
R1749	T2805	T2803	pobj	dish,in
R175	T411	T409	compound	reversal,learning
R1750	T2806	T2807	dep	that,contain
R1751	T2807	T2805	relcl	contain,dish
R1752	T2808	T2807	aux	did,contain
R1753	T2809	T2807	neg	not,contain
R1754	T2810	T2811	det	the,pellet
R1755	T2811	T2807	dobj	pellet,contain
R1756	T2812	T2811	compound	food,pellet
R1757	T2813	T2814	punct	(,S
R1758	T2814	T2802	parataxis	S,digging
R1759	T2815	T2814	punct	-,S
R176	T412	T409	punct	),learning
R1760	T2816	T2814	punct	),S
R1761	T2817	T2818	punct	(,Fig.
R1762	T2818	T2802	parataxis	Fig.,digging
R1763	T2819	T2818	dep	error,Fig.
R1764	T2820	T2819	prep	of,error
R1765	T2821	T2820	pobj	commission,of
R1766	T2822	T2818	punct	;,Fig.
R1767	T2823	T2818	nummod	5A,Fig.
R1768	T2824	T2818	punct	),Fig.
R1769	T2825	T2802	cc	versus,digging
R177	T413	T350	punct	.,compared
R1770	T2826	T2802	conj	failing,digging
R1771	T2827	T2828	aux	to,respond
R1772	T2828	T2826	xcomp	respond,failing
R1773	T2829	T2828	prep	within,respond
R1774	T2830	T2831	nummod	3,min
R1775	T2831	T2829	pobj	min,within
R1776	T2832	T2831	punct	-,min
R1777	T2833	T2831	prep	of,min
R1778	T2834	T2833	pobj	presentation,of
R1779	T2835	T2836	punct	(,Fig.
R178	T417	T418	advmod	Mildly,deprived
R1780	T2836	T2826	parataxis	Fig.,failing
R1781	T2837	T2836	dep	error,Fig.
R1782	T2838	T2837	prep	of,error
R1783	T2839	T2838	pobj	omission,of
R1784	T2840	T2836	punct	;,Fig.
R1785	T2841	T2836	nummod	5B,Fig.
R1786	T2842	T2836	punct	),Fig.
R1787	T2843	T2844	mark	that,committed
R1788	T2844	T2790	ccomp	committed,revealed
R1789	T2845	T2846	det	both,genotypes
R179	T418	T421	amod	deprived,mice
R1790	T2846	T2844	nsubj	genotypes,committed
R1791	T2847	T2844	advmod	chiefly,committed
R1792	T2848	T2844	dobj	errors,committed
R1793	T2849	T2848	prep	of,errors
R1794	T2850	T2849	pobj	commission,of
R1795	T2851	T2848	cc	versus,errors
R1796	T2852	T2848	conj	errors,errors
R1797	T2853	T2852	prep	of,errors
R1798	T2854	T2853	pobj	omission,of
R1799	T2855	T2856	punct	(,0.05
R18	T243	T241	pobj	mice,in
R180	T419	T418	npadvmod	food,deprived
R1800	T2856	T2844	parataxis	0.05,committed
R1801	T2857	T2858	nmod	D2R,mice
R1802	T2858	T2862	dep	mice,0.01
R1803	T2859	T2857	punct	-,D2R
R1804	T2860	T2857	punct	/,D2R
R1805	T2861	T2857	punct	-,D2R
R1806	T2862	T2856	dep	0.01,0.05
R1807	T2863	T2862	punct	", ",0.01
R1808	T2864	T2865	nsubj	U,0.00
R1809	T2865	T2862	ccomp	0.00,0.01
R181	T420	T418	punct	-,deprived
R1810	T2866	T2865	punct	=,0.00
R1811	T2867	T2862	punct	;,0.01
R1812	T2868	T2862	nsubj	p,0.01
R1813	T2869	T2862	punct	<,0.01
R1814	T2870	T2856	punct	;,0.05
R1815	T2871	T2872	nmod	D2R,mice
R1816	T2872	T2856	dep	mice,0.05
R1817	T2873	T2871	punct	+,D2R
R1818	T2874	T2871	punct	/,D2R
R1819	T2875	T2871	punct	+,D2R
R182	T421	T431	nsubj	mice,learned
R1820	T2876	T2877	nsubj	U,9.00
R1821	T2877	T2856	ccomp	9.00,0.05
R1822	T2878	T2877	punct	=,9.00
R1823	T2879	T2856	punct	", ",0.05
R1824	T2880	T2856	nsubj	p,0.05
R1825	T2881	T2856	punct	<,0.05
R1826	T2882	T2856	punct	),0.05
R1827	T2883	T2844	punct	", ",committed
R1828	T2884	T2885	nmod	D2R,mice
R1829	T2885	T2889	nsubj	mice,committed
R183	T422	T421	amod	female,mice
R1830	T2886	T2884	punct	-,D2R
R1831	T2887	T2884	punct	/,D2R
R1832	T2888	T2884	punct	-,D2R
R1833	T2889	T2844	conj	committed,committed
R1834	T2890	T2891	amod	more,errors
R1835	T2891	T2889	dobj	errors,committed
R1836	T2892	T2891	compound	commission,errors
R1837	T2893	T2891	prep	than,errors
R1838	T2894	T2895	nmod	D2R,mice
R1839	T2895	T2893	pobj	mice,than
R184	T423	T424	amod	wild,type
R1840	T2896	T2894	punct	+,D2R
R1841	T2897	T2894	punct	/,D2R
R1842	T2898	T2894	punct	+,D2R
R1843	T2899	T2900	punct	(,0.05
R1844	T2900	T2889	parataxis	0.05,committed
R1845	T2901	T2902	nsubj	U,5.00
R1846	T2902	T2900	ccomp	5.00,0.05
R1847	T2903	T2902	punct	=,5.00
R1848	T2904	T2900	punct	", ",0.05
R1849	T2905	T2900	nsubj	p,0.05
R185	T424	T421	nmod	type,mice
R1850	T2906	T2900	punct	<,0.05
R1851	T2907	T2900	punct	),0.05
R1852	T2908	T2889	punct	", ",committed
R1853	T2909	T2889	cc	and,committed
R1854	T2910	T2911	expl	there,were
R1855	T2911	T2889	conj	were,committed
R1856	T2912	T2913	det	no,differences
R1857	T2913	T2911	attr	differences,were
R1858	T2914	T2913	prep	between,differences
R1859	T2915	T2916	nmod	D2R,mice
R186	T425	T424	punct	-,type
R1860	T2916	T2914	pobj	mice,between
R1861	T2917	T2915	punct	-,D2R
R1862	T2918	T2915	punct	/,D2R
R1863	T2919	T2915	punct	-,D2R
R1864	T2920	T2915	cc	and,D2R
R1865	T2921	T2915	conj	D2R,D2R
R1866	T2922	T2921	punct	+,D2R
R1867	T2923	T2921	punct	/,D2R
R1868	T2924	T2921	punct	+,D2R
R1869	T2925	T2913	prep	in,differences
R187	T426	T424	cc	and,type
R1870	T2926	T2927	compound	omission,errors
R1871	T2927	T2925	pobj	errors,in
R1872	T2928	T2929	punct	(,0.65
R1873	T2929	T2911	parataxis	0.65,were
R1874	T2930	T2931	nsubj	U,27.5
R1875	T2931	T2929	ccomp	27.5,0.65
R1876	T2932	T2931	punct	=,27.5
R1877	T2933	T2929	punct	", ",0.65
R1878	T2934	T2929	nsubj	p,0.65
R1879	T2935	T2929	punct	=,0.65
R188	T427	T428	compound	dopamine,receptor
R1880	T2936	T2929	punct	),0.65
R1881	T2937	T2790	punct	.,revealed
R1882	T2939	T2940	advmod	Moreover,indicated
R1883	T2941	T2940	punct	", ",indicated
R1884	T2942	T2943	det	the,number
R1885	T2943	T2940	nsubj	number,indicated
R1886	T2944	T2943	prep	of,number
R1887	T2945	T2946	compound	commission,errors
R1888	T2946	T2944	pobj	errors,of
R1889	T2947	T2943	acl	committed,number
R189	T428	T430	npadvmod	receptor,deficient
R1890	T2948	T2947	prep	during,committed
R1891	T2949	T2950	det	the,session
R1892	T2950	T2948	pobj	session,during
R1893	T2951	T2950	amod	first,session
R1894	T2952	T2950	compound	reversal,session
R1895	T2953	T2943	punct	(,number
R1896	T2954	T2955	det	an,index
R1897	T2955	T2943	appos	index,number
R1898	T2956	T2955	prep	of,index
R1899	T2957	T2958	nmod	stimulus,perseveration
R19	T244	T242	punct	/,C57BL
R190	T429	T428	compound	D2,receptor
R1900	T2958	T2956	pobj	perseveration,of
R1901	T2959	T2957	amod	bound,stimulus
R1902	T2960	T2955	punct	", ",index
R1903	T2961	T2962	advmod	where,responding
R1904	T2962	T2955	relcl	responding,index
R1905	T2963	T2964	det	all,animals
R1906	T2964	T2962	nsubj	animals,responding
R1907	T2965	T2962	aux	are,responding
R1908	T2966	T2962	prep	to,responding
R1909	T2967	T2968	det	the,contingencies
R191	T430	T424	conj	deficient,type
R1910	T2968	T2966	pobj	contingencies,to
R1911	T2969	T2968	amod	reversed,contingencies
R1912	T2970	T2962	prep	for,responding
R1913	T2971	T2972	det	the,time
R1914	T2972	T2970	pobj	time,for
R1915	T2973	T2972	amod	first,time
R1916	T2974	T2975	punct	;,Fig.
R1917	T2975	T2943	parataxis	Fig.,number
R1918	T2976	T2975	nummod	6,Fig.
R1919	T2977	T2975	punct	),Fig.
R192	T432	T431	advmod	rapidly,learned
R1920	T2978	T2979	det	a,deficit
R1921	T2979	T2940	dobj	deficit,indicated
R1922	T2980	T2940	prep	in,indicated
R1923	T2981	T2982	det	the,mice
R1924	T2982	T2980	pobj	mice,in
R1925	T2983	T2982	nmod	D2R,mice
R1926	T2984	T2983	punct	-,D2R
R1927	T2985	T2983	punct	/,D2R
R1928	T2986	T2983	punct	-,D2R
R1929	T2987	T2940	prep	compared,indicated
R193	T433	T434	aux	to,retrieve
R1930	T2988	T2987	prep	to,compared
R1931	T2989	T2990	det	the,mice
R1932	T2990	T2988	pobj	mice,to
R1933	T2991	T2990	nmod	D2R,mice
R1934	T2992	T2991	punct	+,D2R
R1935	T2993	T2991	punct	/,D2R
R1936	T2994	T2991	punct	+,D2R
R1937	T2995	T2996	punct	(,0.01
R1938	T2996	T2940	parataxis	0.01,indicated
R1939	T2997	T2998	nsubj	U,8.5
R194	T434	T431	xcomp	retrieve,learned
R1940	T2998	T2996	ccomp	8.5,0.01
R1941	T2999	T2998	punct	=,8.5
R1942	T3000	T2996	punct	", ",0.01
R1943	T3001	T2996	nsubj	p,0.01
R1944	T3002	T2996	punct	<,0.01
R1945	T3003	T2996	punct	),0.01
R1946	T3004	T2940	punct	.,indicated
R1947	T3006	T3007	advmod	Finally,analyzed
R1948	T3008	T3007	punct	", ",analyzed
R1949	T3009	T3007	prep	in,analyzed
R195	T435	T434	cc	and,retrieve
R1950	T3010	T3011	det	an,attempt
R1951	T3011	T3009	pobj	attempt,in
R1952	T3012	T3013	aux	to,assess
R1953	T3013	T3011	acl	assess,attempt
R1954	T3014	T3015	mark	whether,occurred
R1955	T3015	T3013	ccomp	occurred,assess
R1956	T3016	T3015	nsubj	perseveration,occurred
R1957	T3017	T3015	prep	across,occurred
R1958	T3018	T3019	amod	multiple,sessions
R1959	T3019	T3017	pobj	sessions,across
R196	T436	T434	conj	consume,retrieve
R1960	T3020	T3019	compound	reversal,sessions
R1961	T3021	T3022	punct	(,Fig.
R1962	T3022	T3013	parataxis	Fig.,assess
R1963	T3023	T3022	nummod	7,Fig.
R1964	T3024	T3022	punct	),Fig.
R1965	T3025	T3007	punct	", ",analyzed
R1966	T3026	T3007	nsubj	we,analyzed
R1967	T3027	T3028	det	the,number
R1968	T3028	T3007	dobj	number,analyzed
R1969	T3029	T3028	prep	of,number
R197	T437	T438	amod	visible,reinforcers
R1970	T3030	T3031	compound	commission,errors
R1971	T3031	T3029	pobj	errors,of
R1972	T3032	T3028	acl	emitted,number
R1973	T3033	T3032	prep	before,emitted
R1974	T3034	T3033	pcomp	relearning,before
R1975	T3035	T3036	det	the,contingencies
R1976	T3036	T3034	dobj	contingencies,relearning
R1977	T3037	T3036	compound	reinforcement,contingencies
R1978	T3038	T3034	prep	during,relearning
R1979	T3039	T3040	det	the,sessions
R198	T438	T436	dobj	reinforcers,consume
R1980	T3040	T3038	pobj	sessions,during
R1981	T3041	T3040	amod	reversal,sessions
R1982	T3042	T3007	punct	.,analyzed
R1983	T3044	T3045	det	The,data
R1984	T3045	T3046	nsubjpass	data,collected
R1985	T3047	T3045	acl	depicted,data
R1986	T3048	T3046	auxpass	were,collected
R1987	T3049	T3046	prep	from,collected
R1988	T3050	T3049	pobj	subjects,from
R1989	T3051	T3052	dep	that,achieved
R199	T439	T438	compound	food,reinforcers
R1990	T3052	T3050	relcl	achieved,subjects
R1991	T3053	T3052	aux	had,achieved
R1992	T3054	T3052	neg	not,achieved
R1993	T3055	T3056	det	the,criterion
R1994	T3056	T3052	dobj	criterion,achieved
R1995	T3057	T3058	nummod	80,%
R1996	T3058	T3059	compound	%,performance
R1997	T3059	T3056	compound	performance,criterion
R1998	T3060	T3046	punct	.,collected
R1999	T3062	T3063	advmod	Therefore,5
R20	T245	T242	nummod	6,C57BL
R200	T440	T436	prep	from,consume
R2000	T3064	T3063	punct	", ",5
R2001	T3065	T3066	det	the,number
R2002	T3066	T3067	nsubj	number,is
R2003	T3067	T3063	ccomp	is,5
R2004	T3068	T3066	prep	of,number
R2005	T3069	T3070	nmod	D2R,mice
R2006	T3070	T3068	pobj	mice,of
R2007	T3071	T3069	punct	+,D2R
R2008	T3072	T3069	punct	/,D2R
R2009	T3073	T3069	punct	+,D2R
R201	T441	T442	det	a,dish
R2010	T3074	T3066	acl	represented,number
R2011	T3075	T3074	prep	in,represented
R2012	T3076	T3077	compound	session,#
R2013	T3077	T3075	pobj	#,in
R2014	T3078	T3077	nummod	1,#
R2015	T3079	T3067	attr	8,is
R2016	T3080	T3063	punct	", ",5
R2017	T3081	T3082	prep	in,8
R2018	T3082	T3063	ccomp	8,5
R2019	T3083	T3084	compound	session,#
R202	T442	T440	pobj	dish,from
R2020	T3084	T3081	pobj	#,in
R2021	T3085	T3084	nummod	2,#
R2022	T3086	T3082	nsubj	n,8
R2023	T3087	T3082	punct	=,8
R2024	T3088	T3063	punct	", ",5
R2025	T3089	T3090	compound	session,#
R2026	T3090	T3091	npadvmod	#,6
R2027	T3091	T3063	ccomp	6,5
R2028	T3092	T3090	nummod	3,#
R2029	T3093	T3091	nsubj	n,6
R203	T443	T442	amod	small,dish
R2030	T3094	T3091	punct	=,6
R2031	T3095	T3096	punct	(,met
R2032	T3096	T3091	parataxis	met,6
R2033	T3097	T3098	nummod	2,mice
R2034	T3098	T3096	nsubj	mice,met
R2035	T3099	T3100	poss	our,criterion
R2036	T3100	T3096	dobj	criterion,met
R2037	T3101	T3096	punct	),met
R2038	T3102	T3063	punct	", ",5
R2039	T3103	T3063	prep	in,5
R204	T444	T442	amod	plastic,dish
R2040	T3104	T3105	compound	session,#
R2041	T3105	T3103	pobj	#,in
R2042	T3106	T3105	nummod	4,#
R2043	T3107	T3063	nsubj	n,5
R2044	T3108	T3063	punct	=,5
R2045	T3109	T3110	punct	(,met
R2046	T3110	T3063	parataxis	met,5
R2047	T3111	T3110	nsubj	three,met
R2048	T3112	T3113	det	the,criterion
R2049	T3113	T3110	dobj	criterion,met
R205	T445	T431	punct	.,learned
R2050	T3114	T3110	punct	),met
R2051	T3115	T3063	punct	.,5
R2052	T3117	T3118	prep	Following,met
R2053	T3119	T3117	pobj	session,Following
R2054	T3120	T3119	nummod	5,session
R2055	T3121	T3118	punct	", ",met
R2056	T3122	T3123	det	the,mice
R2057	T3123	T3118	nsubj	mice,met
R2058	T3124	T3123	amod	remaining,mice
R2059	T3125	T3123	nummod	5,mice
R206	T447	T448	advmod	Furthermore,learned
R2060	T3126	T3123	nmod	D2R,mice
R2061	T3127	T3126	punct	+,D2R
R2062	T3128	T3126	punct	/,D2R
R2063	T3129	T3126	punct	+,D2R
R2064	T3130	T3118	aux	had,met
R2065	T3131	T3118	dobj	criteria,met
R2066	T3132	T3118	punct	.,met
R2067	T3134	T3135	prep	For,represents
R2068	T3136	T3137	det	the,mice
R2069	T3137	T3134	pobj	mice,For
R207	T449	T448	punct	", ",learned
R2070	T3138	T3137	nmod	D2R,mice
R2071	T3139	T3138	punct	-,D2R
R2072	T3140	T3138	punct	/,D2R
R2073	T3141	T3138	punct	-,D2R
R2074	T3142	T3135	punct	", ",represents
R2075	T3143	T3144	det	each,point
R2076	T3144	T3135	nsubj	point,represents
R2077	T3145	T3144	prep	on,point
R2078	T3146	T3147	det	the,graph
R2079	T3147	T3145	pobj	graph,on
R208	T450	T451	det	both,genotypes
R2080	T3148	T3149	nummod	8,subjects
R2081	T3149	T3135	dobj	subjects,represents
R2082	T3150	T3135	punct	.,represents
R2083	T3152	T3153	nsubj	None,achieved
R2084	T3154	T3152	prep	of,None
R2085	T3155	T3156	det	the,mice
R2086	T3156	T3154	pobj	mice,of
R2087	T3157	T3156	nmod	D2R,mice
R2088	T3158	T3157	punct	-,D2R
R2089	T3159	T3157	punct	/,D2R
R209	T451	T448	nsubj	genotypes,learned
R2090	T3160	T3157	punct	-,D2R
R2091	T3161	T3162	det	the,criterion
R2092	T3162	T3153	dobj	criterion,achieved
R2093	T3163	T3162	prep	of,criterion
R2094	T3164	T3165	nummod	80,%
R2095	T3165	T3166	compound	%,accuracy
R2096	T3166	T3163	pobj	accuracy,of
R2097	T3167	T3153	prep	by,achieved
R2098	T3168	T3167	pobj	session,by
R2099	T3169	T3168	nummod	5,session
R21	T250	T251	compound	Dopamine,modulation
R210	T452	T448	advmod	readily,learned
R2100	T3170	T3153	punct	.,achieved
R2101	T3172	T3173	prep	For,was
R2102	T3174	T3175	det	the,ANOVA
R2103	T3175	T3172	pobj	ANOVA,For
R2104	T3176	T3175	amod	overall,ANOVA
R2105	T3177	T3178	nummod	2,way
R2106	T3178	T3175	compound	way,ANOVA
R2107	T3179	T3178	punct	-,way
R2108	T3180	T3173	punct	", ",was
R2109	T3181	T3173	expl	there,was
R211	T453	T454	aux	to,dig
R2110	T3182	T3183	det	a,difference
R2111	T3183	T3173	attr	difference,was
R2112	T3184	T3183	amod	significant,difference
R2113	T3185	T3183	prep	between,difference
R2114	T3186	T3185	pobj	genotypes,between
R2115	T3187	T3183	prep	for,difference
R2116	T3188	T3189	det	the,number
R2117	T3189	T3187	pobj	number,for
R2118	T3190	T3189	prep	of,number
R2119	T3191	T3192	amod	perseverative,errors
R212	T454	T448	xcomp	dig,learned
R2120	T3192	T3190	pobj	errors,of
R2121	T3193	T3194	punct	(,0.001
R2122	T3194	T3173	parataxis	0.001,was
R2123	T3195	T3196	nsubj	F1,16.61
R2124	T3196	T3194	ccomp	16.61,0.001
R2125	T3197	T3195	punct	",",F1
R2126	T3198	T3195	nummod	51,F1
R2127	T3199	T3196	punct	=,16.61
R2128	T3200	T3194	punct	", ",0.001
R2129	T3201	T3194	nsubj	p,0.001
R213	T455	T454	prep	through,dig
R2130	T3202	T3194	punct	<,0.001
R2131	T3203	T3194	punct	),0.001
R2132	T3204	T3173	punct	.,was
R214	T456	T457	det	the,dish
R2145	T4023	T4024	prep	In,sought
R2146	T4025	T4026	det	this,study
R2147	T4026	T4023	pobj	study,In
R2148	T4027	T4024	punct	", ",sought
R2149	T4028	T4024	nsubj	we,sought
R215	T457	T455	pobj	dish,through
R2150	T4029	T4030	aux	to,determine
R2151	T4030	T4024	xcomp	determine,sought
R2152	T4031	T4032	det	the,contribution
R2153	T4032	T4030	dobj	contribution,determine
R2154	T4033	T4032	prep	of,contribution
R2155	T4034	T4035	compound	dopamine,D2
R2156	T4035	T4036	compound	D2,receptor
R2157	T4036	T4037	npadvmod	receptor,mediated
R2158	T4037	T4039	amod	mediated,signaling
R2159	T4038	T4037	punct	-,mediated
R216	T458	T457	amod	same,dish
R2160	T4039	T4033	pobj	signaling,of
R2161	T4040	T4032	prep	to,contribution
R2162	T4041	T4042	det	the,stages
R2163	T4042	T4040	pobj	stages,to
R2164	T4043	T4042	amod	various,stages
R2165	T4044	T4042	prep	of,stages
R2166	T4045	T4046	amod	associative,learning
R2167	T4046	T4044	pobj	learning,of
R2168	T4047	T4045	cc	and,associative
R2169	T4048	T4045	conj	reversal,associative
R217	T459	T457	acl	filled,dish
R2170	T4049	T4024	punct	.,sought
R2171	T4051	T4052	nmod	D2R,mice
R2172	T4052	T4056	nsubj	mice,demonstrated
R2173	T4053	T4051	punct	-,D2R
R2174	T4054	T4051	punct	/,D2R
R2175	T4055	T4051	punct	-,D2R
R2176	T4057	T4058	mark	that,were
R2177	T4058	T4056	ccomp	were,demonstrated
R2178	T4059	T4058	nsubj	they,were
R2179	T4060	T4058	acomp	capable,were
R218	T460	T459	prep	with,filled
R2180	T4061	T4060	prep	of,capable
R2181	T4062	T4061	pcomp	learning,of
R2182	T4063	T4064	aux	to,locate
R2183	T4064	T4062	xcomp	locate,learning
R2184	T4065	T4064	cc	and,locate
R2185	T4066	T4064	conj	consume,locate
R2186	T4067	T4068	compound	food,pellets
R2187	T4068	T4066	dobj	pellets,consume
R2188	T4069	T4056	punct	", ",demonstrated
R2189	T4070	T4056	advcl	indicating,demonstrated
R219	T461	T462	amod	sterile,sand
R2190	T4071	T4072	mark	that,disrupted
R2191	T4072	T4070	ccomp	disrupted,indicating
R2192	T4073	T4074	poss	their,behavior
R2193	T4074	T4072	nsubjpass	behavior,disrupted
R2194	T4075	T4074	compound	locomotor,behavior
R2195	T4076	T4072	auxpass	was,disrupted
R2196	T4077	T4072	neg	not,disrupted
R2197	T4078	T4072	advmod	detectably,disrupted
R2198	T4079	T4072	cc	and,disrupted
R2199	T4080	T4081	poss	their,motivation
R22	T251	T252	nsubj	modulation,is
R220	T462	T460	pobj	sand,with
R2200	T4081	T4083	nsubj	motivation,was
R2201	T4082	T4081	amod	primary,motivation
R2202	T4083	T4072	conj	was,disrupted
R2203	T4084	T4085	aux	to,obtain
R2204	T4085	T4081	acl	obtain,motivation
R2205	T4086	T4087	det	a,reinforcer
R2206	T4087	T4085	dobj	reinforcer,obtain
R2207	T4088	T4087	amod	natural,reinforcer
R2208	T4089	T4087	punct	(,reinforcer
R2209	T4090	T4091	compound	food,pellet
R221	T463	T454	prep	in,dig
R2210	T4091	T4087	appos	pellet,reinforcer
R2211	T4092	T4087	punct	),reinforcer
R2212	T4093	T4083	acomp	undisturbed,was
R2213	T4094	T4056	punct	.,demonstrated
R2214	T4096	T4097	advmod	Rather,argues
R2215	T4098	T4097	punct	", ",argues
R2216	T4099	T4100	det	the,ability
R2217	T4100	T4097	nsubj	ability,argues
R2218	T4101	T4100	amod	impaired,ability
R2219	T4102	T4100	prep	of,ability
R222	T464	T463	pobj	order,in
R2220	T4103	T4104	nmod	D2R,mice
R2221	T4104	T4102	pobj	mice,of
R2222	T4105	T4103	punct	-,D2R
R2223	T4106	T4103	punct	/,D2R
R2224	T4107	T4103	punct	-,D2R
R2225	T4108	T4109	aux	to,assign
R2226	T4109	T4100	acl	assign,ability
R2227	T4110	T4111	amod	appropriate,relationships
R2228	T4111	T4109	dobj	relationships,assign
R2229	T4112	T4113	amod	discriminative,stimulus
R223	T465	T466	aux	to,locate
R2230	T4113	T4111	compound	stimulus,relationships
R2231	T4114	T4109	prep	in,assign
R2232	T4115	T4116	det	an,task
R2233	T4116	T4114	pobj	task,in
R2234	T4117	T4116	compound	operant,task
R2235	T4118	T4116	compound	discrimination,task
R2236	T4119	T4120	mark	that,contributes
R2237	T4120	T4097	ccomp	contributes,argues
R2238	T4121	T4122	npadvmod	D2R,mediated
R2239	T4122	T4124	amod	mediated,signaling
R224	T466	T464	acl	locate,order
R2240	T4123	T4122	punct	-,mediated
R2241	T4124	T4120	nsubj	signaling,contributes
R2242	T4125	T4120	prep	to,contributes
R2243	T4126	T4127	det	the,processes
R2244	T4127	T4125	pobj	processes,to
R2245	T4128	T4127	amod	neuronal,processes
R2246	T4129	T4127	acl	involved,processes
R2247	T4130	T4129	prep	in,involved
R2248	T4131	T4130	pcomp	attaching,in
R2249	T4132	T4131	dobj	salience,attaching
R225	T467	T468	det	a,pellet
R2250	T4133	T4131	prep	to,attaching
R2251	T4134	T4135	amod	environmental,stimuli
R2252	T4135	T4133	pobj	stimuli,to
R2253	T4136	T4097	punct	.,argues
R2254	T4138	T4139	det	The,capacity
R2255	T4139	T4141	nsubj	capacity,argues
R2256	T4140	T4139	amod	deficient,capacity
R2257	T4142	T4139	prep	of,capacity
R2258	T4143	T4144	nmod	D2R,mice
R2259	T4144	T4142	pobj	mice,of
R226	T468	T466	dobj	pellet,locate
R2260	T4145	T4143	punct	-,D2R
R2261	T4146	T4143	punct	/,D2R
R2262	T4147	T4143	punct	-,D2R
R2263	T4148	T4149	aux	to,disengage
R2264	T4149	T4139	acl	disengage,capacity
R2265	T4150	T4151	amod	inappropriate,strategies
R2266	T4151	T4149	dobj	strategies,disengage
R2267	T4152	T4151	compound	decision,strategies
R2268	T4153	T4141	advmod	strongly,argues
R2269	T4154	T4155	mark	that,is
R227	T469	T468	amod	buried,pellet
R2270	T4155	T4141	ccomp	is,argues
R2271	T4156	T4157	amod	mesolimbic,signaling
R2272	T4157	T4155	nsubj	signaling,is
R2273	T4158	T4157	compound	dopamine,signaling
R2274	T4159	T4157	punct	", ",signaling
R2275	T4160	T4157	acl	mediated,signaling
R2276	T4161	T4160	agent	by,mediated
R2277	T4162	T4163	compound	dopamine,D2Rs
R2278	T4163	T4161	pobj	D2Rs,by
R2279	T4164	T4155	acomp	essential,is
R228	T470	T468	compound	food,pellet
R2280	T4165	T4166	mark	for,occur
R2281	T4166	T4155	advcl	occur,is
R2282	T4167	T4168	amod	efficient,learning
R2283	T4168	T4166	nsubj	learning,occur
R2284	T4169	T4168	compound	reversal,learning
R2285	T4170	T4166	aux	to,occur
R2286	T4171	T4141	punct	.,argues
R2287	T4173	T4174	nsubj	Mice,displayed
R2288	T4175	T4173	prep	with,Mice
R2289	T4176	T4175	cc	or,with
R229	T471	T448	punct	.,learned
R2290	T4177	T4175	conj	without,with
R2291	T4178	T4179	amod	intact,signaling
R2292	T4179	T4177	pobj	signaling,without
R2293	T4180	T4181	compound	dopamine,D2R
R2294	T4181	T4182	npadvmod	D2R,mediated
R2295	T4182	T4179	amod	mediated,signaling
R2296	T4183	T4182	punct	-,mediated
R2297	T4184	T4185	amod	similar,decreases
R2298	T4185	T4174	dobj	decreases,displayed
R2299	T4186	T4185	prep	in,decreases
R23	T253	T251	prep	of,modulation
R230	T473	T474	advmod	However,required
R2300	T4187	T4186	pobj	latencies,in
R2301	T4188	T4189	aux	to,retrieve
R2302	T4189	T4187	acl	retrieve,latencies
R2303	T4190	T4191	amod	unhidden,pellets
R2304	T4191	T4189	dobj	pellets,retrieve
R2305	T4192	T4191	compound	food,pellets
R2306	T4193	T4194	punct	(,Fig.
R2307	T4194	T4174	parataxis	Fig.,displayed
R2308	T4195	T4194	nummod	1,Fig.
R2309	T4196	T4194	punct	),Fig.
R231	T475	T474	punct	", ",required
R2310	T4197	T4174	cc	and,displayed
R2311	T4198	T4174	conj	learned,displayed
R2312	T4199	T4200	aux	to,dig
R2313	T4200	T4198	xcomp	dig,learned
R2314	T4201	T4200	prep	for,dig
R2315	T4202	T4201	pobj	food,for
R2316	T4203	T4202	acl	buried,food
R2317	T4204	T4203	prep	in,buried
R2318	T4205	T4206	amod	unscented,sand
R2319	T4206	T4204	pobj	sand,in
R232	T476	T477	det	the,mice
R2320	T4207	T4208	punct	(,Fig.
R2321	T4208	T4200	parataxis	Fig.,dig
R2322	T4209	T4208	nummod	2,Fig.
R2323	T4210	T4208	punct	),Fig.
R2324	T4211	T4174	punct	.,displayed
R2325	T4213	T4214	det	These,findings
R2326	T4214	T4215	nsubj	findings,are
R2327	T4216	T4215	prep	in,are
R2328	T4217	T4218	amod	complete,agreement
R2329	T4218	T4216	pobj	agreement,in
R233	T477	T474	nsubj	mice,required
R2330	T4219	T4218	prep	with,agreement
R2331	T4220	T4221	amod	earlier,studies
R2332	T4221	T4219	pobj	studies,with
R2333	T4222	T4223	dep	that,utilized
R2334	T4223	T4221	relcl	utilized,studies
R2335	T4224	T4223	dobj	rats,utilized
R2336	T4225	T4224	cc	and,rats
R2337	T4226	T4227	advmod	fairly,selective
R2338	T4227	T4228	amod	selective,antagonists
R2339	T4228	T4224	conj	antagonists,rats
R234	T478	T479	compound	dopamine,D2
R2340	T4229	T4228	compound	D2R,antagonists
R2341	T4230	T4231	punct	[,3
R2342	T4231	T4228	parataxis	3,antagonists
R2343	T4232	T4233	punct	-,8
R2344	T4233	T4231	prep	8,3
R2345	T4234	T4231	punct	],3
R2346	T4235	T4224	punct	", ",rats
R2347	T4236	T4237	advmod	as,as
R2348	T4237	T4224	cc	as,rats
R2349	T4238	T4237	advmod	well,as
R235	T479	T480	compound	D2,receptor
R2350	T4239	T4240	advmod	even,lesions
R2351	T4240	T4224	conj	lesions,rats
R2352	T4241	T4242	advmod	very,extensive
R2353	T4242	T4240	amod	extensive,lesions
R2354	T4243	T4244	nummod	6,OHDA
R2355	T4244	T4240	compound	OHDA,lesions
R2356	T4245	T4244	punct	-,OHDA
R2357	T4246	T4247	punct	[,11
R2358	T4247	T4240	parataxis	11,lesions
R2359	T4248	T4247	nummod	1,11
R236	T480	T481	npadvmod	receptor,deficient
R2360	T4249	T4247	punct	",",11
R2361	T4250	T4247	nummod	10,11
R2362	T4251	T4247	punct	",",11
R2363	T4252	T4247	punct	],11
R2364	T4253	T4223	prep	in,utilized
R2365	T4254	T4255	amod	associative,paradigms
R2366	T4255	T4253	pobj	paradigms,in
R2367	T4256	T4254	cc	and,associative
R2368	T4257	T4254	conj	operant,associative
R2369	T4258	T4255	compound	learning,paradigms
R237	T481	T477	amod	deficient,mice
R2370	T4259	T4215	punct	.,are
R2371	T4261	T4262	poss	Our,results
R2372	T4262	T4263	nsubj	results,add
R2373	T4264	T4263	prep	to,add
R2374	T4265	T4266	det	a,literature
R2375	T4266	T4264	pobj	literature,to
R2376	T4267	T4266	amod	growing,literature
R2377	T4268	T4266	acl	demonstrating,literature
R2378	T4269	T4270	det	a,role
R2379	T4270	T4268	dobj	role,demonstrating
R238	T482	T483	advmod	significantly,more
R2380	T4271	T4270	amod	negligible,role
R2381	T4272	T4270	prep	of,role
R2382	T4273	T4272	pobj	dopamine,of
R2383	T4274	T4273	punct	", ",dopamine
R2384	T4275	T4273	cc	and,dopamine
R2385	T4276	T4277	advmod	now,D2Rs
R2386	T4277	T4273	conj	D2Rs,dopamine
R2387	T4278	T4277	punct	", ",D2Rs
R2388	T4279	T4277	advmod	specifically,D2Rs
R2389	T4280	T4277	punct	", ",D2Rs
R239	T483	T484	amod	more,trials
R2390	T4281	T4270	prep	in,role
R2391	T4282	T4283	det	the,value
R2392	T4283	T4281	pobj	value,in
R2393	T4284	T4283	amod	unconditioned,value
R2394	T4285	T4284	cc	or,unconditioned
R2395	T4286	T4284	conj	hedonic,unconditioned
R2396	T4287	T4283	prep	of,value
R2397	T4288	T4289	amod	natural,reinforcers
R2398	T4289	T4287	pobj	reinforcers,of
R2399	T4290	T4289	punct	(,reinforcers
R24	T254	T255	amod	neuronal,signaling
R240	T484	T474	dobj	trials,required
R2400	T4291	T4289	nmod	food,reinforcers
R2401	T4292	T4289	punct	),reinforcers
R2402	T4293	T4294	punct	[,2
R2403	T4294	T4289	parataxis	2,reinforcers
R2404	T4295	T4294	nummod	1,2
R2405	T4296	T4294	punct	",",2
R2406	T4297	T4294	punct	],2
R2407	T4298	T4263	punct	.,add
R2408	T4300	T4301	det	The,skill
R2409	T4301	T4304	nsubj	skill,suggests
R241	T485	T484	prep	than,trials
R2410	T4302	T4303	advmod	comparatively,poor
R2411	T4303	T4301	amod	poor,skill
R2412	T4305	T4301	prep	of,skill
R2413	T4306	T4307	nmod	D2R,mice
R2414	T4307	T4305	pobj	mice,of
R2415	T4308	T4306	punct	-,D2R
R2416	T4309	T4306	punct	/,D2R
R2417	T4310	T4306	punct	-,D2R
R2418	T4311	T4301	prep	during,skill
R2419	T4312	T4313	compound	discrimination,trials
R242	T486	T487	amod	wild,type
R2420	T4313	T4311	pobj	trials,during
R2421	T4314	T4315	det	a,role
R2422	T4315	T4304	dobj	role,suggests
R2423	T4316	T4315	prep	for,role
R2424	T4317	T4316	pobj	D2Rs,for
R2425	T4318	T4304	prep	in,suggests
R2426	T4319	T4318	pobj	acquisition,in
R2427	T4320	T4319	prep	of,acquisition
R2428	T4321	T4322	amod	appropriate,relationships
R2429	T4322	T4320	pobj	relationships,of
R243	T487	T489	compound	type,mice
R2430	T4323	T4322	nmod	S,relationships
R2431	T4324	T4323	punct	+,S
R2432	T4325	T4323	punct	/,S
R2433	T4326	T4323	appos	S,S
R2434	T4327	T4326	punct	-,S
R2435	T4328	T4319	prep	in,acquisition
R2436	T4329	T4330	nmod	operant,learning
R2437	T4330	T4328	pobj	learning,in
R2438	T4331	T4330	amod	associative,learning
R2439	T4332	T4304	punct	.,suggests
R244	T488	T487	punct	-,type
R2440	T4334	T4335	amod	Several,studies
R2441	T4335	T4336	nsubj	studies,demonstrated
R2442	T4337	T4336	aux	have,demonstrated
R2443	T4338	T4339	mark	that,mediated
R2444	T4339	T4336	ccomp	mediated,demonstrated
R2445	T4340	T4341	preconj	both,acquisition
R2446	T4341	T4339	nsubjpass	acquisition,mediated
R2447	T4342	T4341	det	the,acquisition
R2448	T4343	T4344	punct	[,7
R2449	T4344	T4341	parataxis	7,acquisition
R245	T489	T485	pobj	mice,than
R2450	T4345	T4344	nummod	6,7
R2451	T4346	T4344	punct	",",7
R2452	T4347	T4344	punct	],7
R2453	T4348	T4341	cc	and,acquisition
R2454	T4349	T4341	conj	expression,acquisition
R2455	T4350	T4351	punct	[,9
R2456	T4351	T4349	parataxis	9,expression
R2457	T4352	T4351	punct	],9
R2458	T4353	T4341	prep	of,acquisition
R2459	T4354	T4355	amod	associative,learning
R246	T490	T491	aux	to,discriminate
R2460	T4355	T4353	pobj	learning,of
R2461	T4356	T4339	auxpass	are,mediated
R2462	T4357	T4339	agent	by,mediated
R2463	T4358	T4359	compound	dopamine,D1Rs
R2464	T4359	T4357	pobj	D1Rs,by
R2465	T4360	T4336	punct	.,demonstrated
R2466	T4362	T4363	amod	Most,reviews
R2467	T4363	T4365	nsubj	reviews,identify
R2468	T4364	T4363	compound	literature,reviews
R2469	T4366	T4367	compound	dopamine,D1Rs
R247	T491	T474	advcl	discriminate,required
R2470	T4367	T4365	dobj	D1Rs,identify
R2471	T4368	T4365	prep	with,identify
R2472	T4369	T4370	npadvmod	dopamine,mediated
R2473	T4370	T4372	amod	mediated,learning
R2474	T4371	T4370	punct	-,mediated
R2475	T4372	T4368	pobj	learning,with
R2476	T4373	T4365	cc	and,identify
R2477	T4374	T4365	conj	D2Rs,identify
R2478	T4375	T4374	prep	with,D2Rs
R2479	T4376	T4377	npadvmod	motor,related
R248	T492	T491	prep	between,discriminate
R2480	T4377	T4378	amod	related,behaviors
R2481	T4378	T4375	pobj	behaviors,with
R2482	T4379	T4380	punct	[,24
R2483	T4380	T4378	parataxis	24,behaviors
R2484	T4381	T4380	advmod	e.g.,24
R2485	T4382	T4380	punct	[,24
R2486	T4383	T4380	punct	],24
R2487	T4384	T4380	punct	],24
R2488	T4385	T4365	punct	.,identify
R2489	T4387	T4388	advmod	Moreover,reported
R249	T493	T494	nummod	two,dishes
R2490	T4389	T4388	punct	", ",reported
R2491	T4390	T4388	nsubjpass	it,reported
R2492	T4391	T4388	aux	has,reported
R2493	T4392	T4388	auxpass	been,reported
R2494	T4393	T4394	mark	that,improves
R2495	T4394	T4388	ccomp	improves,reported
R2496	T4395	T4396	amod	acute,administration
R2497	T4396	T4394	nsubj	administration,improves
R2498	T4397	T4396	prep	of,administration
R2499	T4398	T4399	det	the,antagonist
R25	T255	T253	pobj	signaling,of
R250	T494	T492	pobj	dishes,between
R2500	T4399	T4397	pobj	antagonist,of
R2501	T4400	T4401	nmod	dopamine,D2
R2502	T4401	T4399	nmod	D2,antagonist
R2503	T4402	T4401	punct	/,D2
R2504	T4403	T4401	nummod	3,D2
R2505	T4404	T4399	punct	", ",antagonist
R2506	T4405	T4399	appos	raclopride,antagonist
R2507	T4406	T4394	punct	", ",improves
R2508	T4407	T4394	advmod	actually,improves
R2509	T4408	T4394	dobj	acquisition,improves
R251	T495	T494	punct	", ",dishes
R2510	T4409	T4408	prep	of,acquisition
R2511	T4410	T4411	npadvmod	food,motivated
R2512	T4411	T4413	amod	motivated,learning
R2513	T4412	T4411	punct	-,motivated
R2514	T4413	T4409	pobj	learning,of
R2515	T4414	T4413	amod	associative,learning
R2516	T4415	T4416	punct	[,6
R2517	T4416	T4388	parataxis	6,reported
R2518	T4417	T4416	punct	],6
R2519	T4418	T4388	punct	.,reported
R252	T496	T494	appos	each,dishes
R2520	T4420	T4421	advmod	However,given
R2521	T4422	T4421	punct	", ",given
R2522	T4423	T4424	advmod	only,administrations
R2523	T4424	T4421	nsubjpass	administrations,given
R2524	T4425	T4424	amod	acute,administrations
R2525	T4426	T4424	prep	of,administrations
R2526	T4427	T4426	pobj	antagonists,of
R2527	T4428	T4421	auxpass	were,given
R2528	T4429	T4421	punct	", ",given
R2529	T4430	T4421	cc	and,given
R253	T497	T496	acl	filled,each
R2530	T4431	T4432	nsubjpass	learning,measured
R2531	T4432	T4421	conj	measured,given
R2532	T4433	T4432	auxpass	was,measured
R2533	T4434	T4432	neg	not,measured
R2534	T4435	T4432	prep	during,measured
R2535	T4436	T4437	amod	complete,blockade
R2536	T4437	T4435	pobj	blockade,during
R2537	T4438	T4437	nmod	D1R,blockade
R2538	T4439	T4438	cc	or,D1R
R2539	T4440	T4438	conj	D2R,D1R
R254	T498	T497	prep	with,filled
R2540	T4441	T4442	punct	[,6
R2541	T4442	T4432	parataxis	6,measured
R2542	T4443	T4442	punct	],6
R2543	T4444	T4421	punct	.,given
R2544	T4446	T4447	advmod	Significantly,failed
R2545	T4448	T4447	punct	", ",failed
R2546	T4449	T4450	det	the,reports
R2547	T4450	T4447	nsubj	reports,failed
R2548	T4451	T4450	acl	cited,reports
R2549	T4452	T4451	advmod	above,cited
R255	T499	T500	det	a,sand
R2550	T4453	T4454	aux	to,address
R2551	T4454	T4447	xcomp	address,failed
R2552	T4455	T4456	det	the,limitations
R2553	T4456	T4454	dobj	limitations,address
R2554	T4457	T4456	amod	technical,limitations
R2555	T4458	T4456	prep	of,limitations
R2556	T4459	T4460	det	the,approach
R2557	T4460	T4458	pobj	approach,of
R2558	T4461	T4456	punct	: ,limitations
R2559	T4462	T4463	advmod	i.e.,lack
R256	T500	T498	pobj	sand,with
R2560	T4463	T4456	acl	lack,limitations
R2561	T4464	T4463	mark	that,lack
R2562	T4465	T4466	det	the,antagonists
R2563	T4466	T4463	nsubj	antagonists,lack
R2564	T4467	T4466	acl	used,antagonists
R2565	T4468	T4469	amod	adequate,specificity
R2566	T4469	T4463	dobj	specificity,lack
R2567	T4470	T4469	compound	subtype,specificity
R2568	T4471	T4463	cc	and,lack
R2569	T4472	T4473	advmod	only,partially
R257	T501	T500	amod	different,sand
R2570	T4473	T4474	advmod	partially,blocked
R2571	T4474	T4463	conj	blocked,lack
R2572	T4475	T4476	npadvmod	D2R,mediated
R2573	T4476	T4478	amod	mediated,signaling
R2574	T4477	T4476	punct	-,mediated
R2575	T4478	T4474	dobj	signaling,blocked
R2576	T4479	T4480	advmod	thus,making
R2577	T4480	T4463	advcl	making,lack
R2578	T4481	T4482	nsubj	it,impossible
R2579	T4482	T4480	ccomp	impossible,making
R258	T502	T500	amod	scented,sand
R2580	T4483	T4484	aux	to,assess
R2581	T4484	T4482	advcl	assess,impossible
R2582	T4485	T4484	advmod	rigorously,assess
R2583	T4486	T4487	det	the,role
R2584	T4487	T4484	dobj	role,assess
R2585	T4488	T4487	prep	of,role
R2586	T4489	T4490	npadvmod	D2R,mediated
R2587	T4490	T4492	amod	mediated,signaling
R2588	T4491	T4490	punct	-,mediated
R2589	T4492	T4488	pobj	signaling,of
R259	T503	T491	punct	", ",discriminate
R2590	T4493	T4487	prep	in,role
R2591	T4494	T4495	amod	associative,learning
R2592	T4495	T4493	pobj	learning,in
R2593	T4496	T4494	cc	and,associative
R2594	T4497	T4494	conj	reversal,associative
R2595	T4498	T4447	punct	.,failed
R2596	T4500	T4501	advmod	Additionally,addressed
R2597	T4502	T4501	punct	", ",addressed
R2598	T4503	T4501	nsubj	none,addressed
R2599	T4504	T4503	prep	of,none
R26	T256	T251	prep	in,modulation
R260	T504	T491	cc	and,discriminate
R2600	T4505	T4506	det	these,studies
R2601	T4506	T4504	pobj	studies,of
R2602	T4507	T4508	det	the,observation
R2603	T4508	T4501	dobj	observation,addressed
R2604	T4509	T4510	mark	that,depend
R2605	T4510	T4508	acl	depend,observation
R2606	T4511	T4512	det	the,effects
R2607	T4512	T4510	nsubj	effects,depend
R2608	T4513	T4512	prep	of,effects
R2609	T4514	T4515	compound	D2R,antagonists
R261	T505	T506	aux	to,associate
R2610	T4515	T4513	pobj	antagonists,of
R2611	T4516	T4512	prep	on,effects
R2612	T4517	T4516	pobj	locomotion,on
R2613	T4518	T4517	cc	and,locomotion
R2614	T4519	T4517	conj	learning,locomotion
R2615	T4520	T4510	prep	on,depend
R2616	T4521	T4522	mark	whether,is
R2617	T4522	T4520	pcomp	is,on
R2618	T4523	T4522	nsubj	exposure,is
R2619	T4524	T4522	acomp	chronic,is
R262	T506	T491	conj	associate,discriminate
R2620	T4525	T4524	cc	or,chronic
R2621	T4526	T4524	conj	acute,chronic
R2622	T4527	T4528	punct	[,16
R2623	T4528	T4501	parataxis	16,addressed
R2624	T4529	T4528	advmod	e.g.,16
R2625	T4530	T4528	punct	[,16
R2626	T4531	T4528	nummod	15,16
R2627	T4532	T4528	punct	",",16
R2628	T4533	T4528	punct	],16
R2629	T4534	T4528	punct	],16
R263	T507	T506	dobj	one,associate
R2630	T4535	T4501	punct	.,addressed
R2631	T4537	T4538	mark	That,orchestrates
R2632	T4538	T4543	csubj	orchestrates,is
R2633	T4539	T4540	npadvmod	D2R,mediated
R2634	T4540	T4542	amod	mediated,signaling
R2635	T4541	T4540	punct	-,mediated
R2636	T4542	T4538	nsubj	signaling,orchestrates
R2637	T4544	T4545	advmod	just,components
R2638	T4545	T4538	dobj	components,orchestrates
R2639	T4546	T4545	amod	motor,components
R264	T508	T507	prep	of,one
R2640	T4547	T4545	prep	of,components
R2641	T4548	T4547	pobj	learning,of
R2642	T4549	T4550	det	a,conclusion
R2643	T4550	T4543	attr	conclusion,is
R2644	T4551	T4552	dep	that,is
R2645	T4552	T4550	relcl	is,conclusion
R2646	T4553	T4552	advmod	potentially,is
R2647	T4554	T4552	acomp	biased,is
R2648	T4555	T4552	prep	due,is
R2649	T4556	T4555	pcomp	to,due
R265	T509	T510	det	the,odors
R2650	T4557	T4558	det	the,practice
R2651	T4558	T4555	pobj	practice,due
R2652	T4559	T4558	prep	of,practice
R2653	T4560	T4559	pobj	avoiding,of
R2654	T4561	T4560	dobj	doses,avoiding
R2655	T4562	T4561	prep	of,doses
R2656	T4563	T4562	pobj	drugs,of
R2657	T4564	T4565	dep	that,induce
R2658	T4565	T4561	relcl	induce,doses
R2659	T4566	T4565	dobj	catalepsy,induce
R266	T510	T508	pobj	odors,of
R2660	T4567	T4560	punct	(,avoiding
R2661	T4568	T4560	cc	and,avoiding
R2662	T4569	T4570	advmod	therefore,measuring
R2663	T4570	T4560	conj	measuring,avoiding
R2664	T4571	T4572	advmod	only,blockade
R2665	T4572	T4570	dobj	blockade,measuring
R2666	T4573	T4572	amod	partial,blockade
R2667	T4574	T4572	prep	of,blockade
R2668	T4575	T4576	compound	dopamine,D2Rs
R2669	T4576	T4574	pobj	D2Rs,of
R267	T511	T510	nummod	two,odors
R2670	T4577	T4560	punct	),avoiding
R2671	T4578	T4560	cc	and,avoiding
R2672	T4579	T4580	amod	single,administrations
R2673	T4580	T4560	conj	administrations,avoiding
R2674	T4581	T4582	punct	[,3
R2675	T4582	T4543	parataxis	3,is
R2676	T4583	T4582	advmod	e.g.,3
R2677	T4584	T4582	punct	[,3
R2678	T4585	T4582	punct	],3
R2679	T4586	T4582	punct	],3
R268	T512	T506	prep	with,associate
R2680	T4587	T4543	punct	.,is
R2681	T4589	T4590	advmod	Quite,possibly
R2682	T4590	T4591	advmod	possibly,masked
R2683	T4592	T4591	punct	", ",masked
R2684	T4593	T4594	det	the,role
R2685	T4594	T4591	nsubjpass	role,masked
R2686	T4595	T4594	amod	functional,role
R2687	T4596	T4594	prep	of,role
R2688	T4597	T4596	pobj	D2Rs,of
R2689	T4598	T4594	prep	in,role
R269	T513	T514	det	the,presence
R2690	T4599	T4600	amod	associative,learning
R2691	T4600	T4598	pobj	learning,in
R2692	T4601	T4591	aux	might,masked
R2693	T4602	T4591	auxpass	be,masked
R2694	T4603	T4604	advmod	because,of
R2695	T4604	T4591	prep	of,masked
R2696	T4605	T4606	det	this,concern
R2697	T4606	T4604	pobj	concern,of
R2698	T4607	T4606	prep	about,concern
R2699	T4608	T4609	compound	locomotor,disruption
R27	T257	T258	det	the,cortex
R270	T514	T512	pobj	presence,with
R2700	T4609	T4607	pobj	disruption,about
R2701	T4610	T4611	punct	[,8
R2702	T4611	T4591	parataxis	8,masked
R2703	T4612	T4611	nummod	2,8
R2704	T4613	T4611	punct	",",8
R2705	T4614	T4611	nummod	6,8
R2706	T4615	T4611	punct	",",8
R2707	T4616	T4611	punct	],8
R2708	T4617	T4591	punct	.,masked
R2709	T4619	T4620	nsubj	Doses,disrupt
R271	T515	T514	prep	of,presence
R2710	T4621	T4619	prep	of,Doses
R2711	T4622	T4621	pobj	raclopride,of
R2712	T4623	T4624	advmod	as,0.5
R2713	T4624	T4627	nummod	0.5,mg
R2714	T4625	T4624	amod	low,0.5
R2715	T4626	T4624	quantmod	as,0.5
R2716	T4627	T4619	appos	mg,Doses
R2717	T4628	T4629	punct	/,kg
R2718	T4629	T4627	prep	kg,mg
R2719	T4630	T4620	advmod	significantly,disrupt
R272	T516	T517	det	a,reinforcer
R2720	T4631	T4632	amod	motor,behavior
R2721	T4632	T4620	dobj	behavior,disrupt
R2722	T4633	T4634	punct	[,25
R2723	T4634	T4620	parataxis	25,disrupt
R2724	T4635	T4634	punct	],25
R2725	T4636	T4620	punct	", ",disrupt
R2726	T4637	T4638	mark	although,used
R2727	T4638	T4620	advcl	used,disrupt
R2728	T4639	T4640	det	this,dose
R2729	T4640	T4638	nsubjpass	dose,used
R273	T517	T515	pobj	reinforcer,of
R2730	T4641	T4640	amod	peripheral,dose
R2731	T4642	T4638	auxpass	is,used
R2732	T4643	T4638	advmod	consistently,used
R2733	T4644	T4638	prep	in,used
R2734	T4645	T4646	amod	learning,paradigms
R2735	T4646	T4644	pobj	paradigms,in
R2736	T4647	T4648	punct	[,6
R2737	T4648	T4638	parataxis	6,used
R2738	T4649	T4648	advmod	e.g.,6
R2739	T4650	T4648	punct	[,6
R274	T518	T517	punct	(,reinforcer
R2740	T4651	T4648	punct	],6
R2741	T4652	T4648	punct	],6
R2742	T4653	T4620	punct	.,disrupt
R2743	T4655	T4656	nsubj	One,ask
R2744	T4657	T4656	aux	might,ask
R2745	T4658	T4656	advmod	then,ask
R2746	T4659	T4656	punct	: ,ask
R2747	T4660	T4656	punct	"""",ask
R2748	T4661	T4662	advmod	How,dissociated
R2749	T4662	T4656	ccomp	dissociated,ask
R275	T519	T517	appos	food,reinforcer
R2750	T4663	T4662	advmod	then,dissociated
R2751	T4664	T4662	aux	could,dissociated
R2752	T4665	T4666	det	the,role
R2753	T4666	T4662	nsubjpass	role,dissociated
R2754	T4667	T4666	prep	of,role
R2755	T4668	T4667	pobj	D2Rs,of
R2756	T4669	T4666	prep	in,role
R2757	T4670	T4671	amod	associative,learning
R2758	T4671	T4669	pobj	learning,in
R2759	T4672	T4662	auxpass	be,dissociated
R276	T520	T517	punct	),reinforcer
R2760	T4673	T4662	prep	from,dissociated
R2761	T4674	T4675	amod	motor,behavior
R2762	T4675	T4673	pobj	behavior,from
R2763	T4676	T4656	punct	?,ask
R2764	T4677	T4656	punct	"""",ask
R2765	T4679	T4680	amod	Seminal,experiments
R2766	T4680	T4681	nsubj	experiments,demonstrated
R2767	T4682	T4683	punct	[,26
R2768	T4683	T4680	parataxis	26,experiments
R2769	T4684	T4685	punct	-,28
R277	T521	T474	punct	.,required
R2770	T4685	T4683	prep	28,26
R2771	T4686	T4683	punct	],26
R2772	T4687	T4681	aux	have,demonstrated
R2773	T4688	T4681	advmod	clearly,demonstrated
R2774	T4689	T4690	mark	that,leads
R2775	T4690	T4681	ccomp	leads,demonstrated
R2776	T4691	T4692	amod	repeated,administration
R2777	T4692	T4690	nsubj	administration,leads
R2778	T4693	T4692	prep	of,administration
R2779	T4694	T4695	npadvmod	catalepsy,inducing
R278	T523	T524	prep	In,fail
R2780	T4695	T4697	amod	inducing,doses
R2781	T4696	T4695	punct	-,inducing
R2782	T4697	T4693	pobj	doses,of
R2783	T4698	T4697	prep	of,doses
R2784	T4699	T4700	compound	D2R,antagonists
R2785	T4700	T4698	pobj	antagonists,of
R2786	T4701	T4692	prep	in,administration
R2787	T4702	T4701	pobj	rodents,in
R2788	T4703	T4690	advmod	actually,leads
R2789	T4704	T4690	prep	to,leads
R279	T525	T523	pobj	addition,In
R2790	T4705	T4706	det	a,tolerance
R2791	T4706	T4704	pobj	tolerance,to
R2792	T4707	T4706	amod	striking,tolerance
R2793	T4708	T4706	amod	behavioral,tolerance
R2794	T4709	T4706	prep	to,tolerance
R2795	T4710	T4709	pobj	catalepsy,to
R2796	T4711	T4681	punct	.,demonstrated
R2797	T4713	T4714	det	These,doses
R2798	T4714	T4715	nsubjpass	doses,shown
R2799	T4716	T4715	aux	have,shown
R28	T258	T256	pobj	cortex,in
R280	T526	T524	punct	", ",fail
R2800	T4717	T4715	auxpass	been,shown
R2801	T4718	T4719	aux	to,occupy
R2802	T4719	T4715	xcomp	occupy,shown
R2803	T4720	T4721	advmod	well,80
R2804	T4721	T4723	nummod	80,%
R2805	T4722	T4721	quantmod	over,80
R2806	T4723	T4719	dobj	%,occupy
R2807	T4724	T4723	prep	of,%
R2808	T4725	T4726	amod	available,D2Rs
R2809	T4726	T4724	pobj	D2Rs,of
R281	T527	T528	det	the,mice
R2810	T4727	T4728	punct	[,29
R2811	T4728	T4715	parataxis	29,shown
R2812	T4729	T4728	punct	],29
R2813	T4730	T4715	punct	.,shown
R2814	T4732	T4733	amod	Future,experiments
R2815	T4733	T4734	nsubj	experiments,be
R2816	T4735	T4733	acl	measuring,experiments
R2817	T4736	T4735	dobj	acquisition,measuring
R2818	T4737	T4736	prep	of,acquisition
R2819	T4738	T4739	amod	associative,learning
R282	T528	T524	nsubj	mice,fail
R2820	T4739	T4737	pobj	learning,of
R2821	T4740	T4735	prep	in,measuring
R2822	T4741	T4740	pobj	rodents,in
R2823	T4742	T4743	dep	that,received
R2824	T4743	T4741	relcl	received,rodents
R2825	T4744	T4745	amod	chronic,administration
R2826	T4745	T4743	dobj	administration,received
R2827	T4746	T4745	prep	of,administration
R2828	T4747	T4748	compound	D2R,antagonists
R2829	T4748	T4746	pobj	antagonists,of
R283	T529	T530	compound	dopamine,D2
R2830	T4749	T4743	cc	and,received
R2831	T4750	T4743	conj	demonstrated,received
R2832	T4751	T4752	amod	behavioral,tolerance
R2833	T4752	T4750	dobj	tolerance,demonstrated
R2834	T4753	T4752	prep	to,tolerance
R2835	T4754	T4755	poss	their,effects
R2836	T4755	T4753	pobj	effects,to
R2837	T4756	T4755	nmod	motor,effects
R2838	T4757	T4755	amod	disrupting,effects
R2839	T4758	T4734	aux	would,be
R284	T530	T531	compound	D2,receptor
R2840	T4759	T4760	det	a,test
R2841	T4760	T4734	attr	test,be
R2842	T4761	T4760	amod	logical,test
R2843	T4762	T4760	prep	of,test
R2844	T4763	T4764	det	this,hypothesis
R2845	T4764	T4762	pobj	hypothesis,of
R2846	T4765	T4734	punct	.,be
R2847	T4767	T4768	advmod	However,have
R2848	T4769	T4768	punct	", ",have
R2849	T4770	T4771	det	the,realization
R285	T531	T532	npadvmod	receptor,deficient
R2850	T4771	T4768	nsubj	realization,have
R2851	T4772	T4773	mark	that,targeted
R2852	T4773	T4771	acl	targeted,realization
R2853	T4774	T4775	amod	multiple,subtypes
R2854	T4775	T4773	nsubjpass	subtypes,targeted
R2855	T4776	T4777	compound	dopamine,receptor
R2856	T4777	T4775	compound	receptor,subtypes
R2857	T4778	T4773	aux	would,targeted
R2858	T4863	T4862	amod	parental,strain
R2859	T4779	T4773	auxpass	be,targeted
R286	T532	T528	amod	deficient,mice
R2860	T4864	T4858	prep	for,backcrossed
R2861	T4780	T4773	advmod	concurrently,targeted
R2862	T4865	T4866	det	a,minimum
R2863	T4866	T4864	pobj	minimum,for
R2864	T4867	T4866	prep	of,minimum
R2865	T4781	T4773	prep	with,targeted
R2866	T4868	T4869	nummod	10,generations
R2867	T4869	T4867	pobj	generations,of
R2868	T4782	T4783	det	the,antagonists
R2869	T4870	T4848	punct	),compensation
R287	T533	T524	advmod	repeatedly,fail
R2870	T4871	T4844	punct	", ",revealed
R2871	T4872	T4844	nsubj	use,revealed
R2872	T4783	T4781	pobj	antagonists,with
R2873	T4873	T4872	prep	of,use
R2874	T4874	T4875	poss	our,animals
R2875	T4875	T4873	pobj	animals,of
R2876	T4784	T4785	advmod	presently,available
R2877	T4876	T4875	amod	inbred,animals
R2878	T4877	T4878	punct	(,generation
R2879	T4785	T4783	amod	available,antagonists
R288	T534	T535	aux	to,alter
R2880	T4878	T4875	parataxis	generation,animals
R2881	T4879	T4878	compound	N20,generation
R2882	T4880	T4878	punct	),generation
R2883	T4786	T4785	advmod	commercially,available
R2884	T4881	T4872	prep	in,use
R2885	T4882	T4883	det	the,study
R2886	T4883	T4881	pobj	study,in
R2887	T4787	T4783	punct	", ",antagonists
R2888	T4884	T4883	amod	present,study
R2889	T4885	T4883	punct	(,study
R289	T535	T524	xcomp	alter,fail
R2890	T4886	T4887	advmod	where,detected
R2891	T4788	T4789	amod	such,as
R2892	T4887	T4883	relcl	detected,study
R2893	T4888	T4889	det	no,differences
R2894	T4789	T4783	prep	as,antagonists
R2895	T4889	T4887	nsubjpass	differences,detected
R2896	T4890	T4889	prep	in,differences
R2897	T4891	T4892	compound	locomotor,behavior
R2898	T4790	T4789	pobj	D2Rs,as
R2899	T4892	T4890	pobj	behavior,in
R29	T259	T258	amod	frontal,cortex
R290	T536	T537	poss	their,patterns
R2900	T4791	T4790	punct	", ",D2Rs
R2901	T4893	T4887	auxpass	were,detected
R2902	T4894	T4887	prep	between,detected
R2903	T4895	T4896	nmod	D2R,mice
R2904	T4792	T4790	conj	D3Rs,D2Rs
R2905	T4896	T4894	pobj	mice,between
R2906	T4793	T4792	punct	", ",D3Rs
R2907	T4897	T4895	punct	-,D2R
R2908	T4898	T4895	punct	/,D2R
R2909	T4794	T4792	cc	and,D3Rs
R291	T537	T535	dobj	patterns,alter
R2910	T4899	T4895	punct	-,D2R
R2911	T4900	T4895	cc	and,D2R
R2912	T4901	T4895	conj	D2R,D2R
R2913	T4902	T4901	punct	+,D2R
R2914	T4903	T4901	punct	/,D2R
R2915	T4795	T4792	conj	D4Rs,D3Rs
R2916	T4904	T4901	punct	+,D2R
R2917	T4905	T4906	punct	;,Figs.
R2918	T4906	T4872	parataxis	Figs.,use
R2919	T4796	T4768	aux	would,have
R292	T538	T537	compound	response,patterns
R2920	T4907	T4906	nummod	1,Figs.
R2921	T4908	T4906	cc	&,Figs.
R2922	T4797	T4798	aux	to,rectified
R2923	T4909	T4906	conj	2,Figs.
R2924	T4910	T4906	punct	),Figs.
R2925	T4911	T4912	det	a,role
R2926	T4798	T4768	xcomp	rectified,have
R2927	T4912	T4844	dobj	role,revealed
R2928	T4913	T4914	advmod	previously,unappreciated
R2929	T4914	T4912	amod	unappreciated,role
R293	T539	T535	prep	during,alter
R2930	T4799	T4798	auxpass	be,rectified
R2931	T4915	T4912	prep	of,role
R2932	T4916	T4917	npadvmod	D2R,mediated
R2933	T4800	T4768	punct	.,have
R2934	T4917	T4919	amod	mediated,signaling
R2935	T4918	T4917	punct	-,mediated
R2936	T4919	T4915	pobj	signaling,of
R2937	T4802	T4803	nsubj	We,argue
R2938	T4920	T4912	prep	in,role
R2939	T4921	T4922	amod	associative,learning
R294	T540	T541	compound	reversal,trials
R2940	T4922	T4920	pobj	learning,in
R2941	T4923	T4922	cc	and,learning
R2942	T4804	T4803	aux	would,argue
R2943	T4924	T4922	conj	attention,learning
R2944	T4925	T4926	dep	that,measured
R2945	T4926	T4912	relcl	measured,role
R2946	T4805	T4806	mark	that,is
R2947	T4927	T4926	aux	could,measured
R2948	T4928	T4926	neg	not,measured
R2949	T4929	T4926	auxpass	be,measured
R295	T541	T539	pobj	trials,during
R2950	T4806	T4803	ccomp	is,argue
R2951	T4930	T4926	prep	with,measured
R2952	T4931	T4932	det	the,antagonists
R2953	T4807	T4808	det	the,approach
R2954	T4932	T4930	pobj	antagonists,with
R2955	T4933	T4934	advmod	currently,available
R2956	T4934	T4932	amod	available,antagonists
R2957	T4808	T4806	nsubj	approach,is
R2958	T4935	T4932	punct	", ",antagonists
R2959	T4936	T4937	advmod	acutely,administered
R296	T542	T543	advmod	where,inverted
R2960	T4809	T4810	advmod	most,parsimonious
R2961	T4937	T4932	amod	administered,antagonists
R2962	T4938	T4932	compound	D2R,antagonists
R2963	T4939	T4844	punct	.,revealed
R2964	T4941	T4942	det	A,analysis
R2965	T4942	T4944	nsubj	analysis,suggest
R2966	T4810	T4808	amod	parsimonious,approach
R2967	T4943	T4942	amod	cursory,analysis
R2968	T4945	T4942	prep	of,analysis
R2969	T4811	T4808	prep	at,approach
R297	T543	T541	relcl	inverted,trials
R2970	T4946	T4947	poss	our,data
R2971	T4947	T4945	pobj	data,of
R2972	T4812	T4813	det	this,time
R2973	T4948	T4944	aux	might,suggest
R2974	T4949	T4944	prep	to,suggest
R2975	T4950	T4949	pobj	some,to
R2976	T4813	T4811	pobj	time,at
R2977	T4951	T4952	mark	that,conferred
R2978	T4952	T4944	ccomp	conferred,suggest
R2979	T4814	T4815	aux	to,utilize
R298	T544	T545	det	the,rules
R2980	T4953	T4954	det	the,manipulation
R2981	T4954	T4952	nsubj	manipulation,conferred
R2982	T4955	T4954	amod	genetic,manipulation
R2983	T4815	T4806	xcomp	utilize,is
R2984	T4956	T4954	prep	of,manipulation
R2985	T4957	T4958	det	the,locus
R2986	T4958	T4956	pobj	locus,of
R2987	T4816	T4815	dobj	mice,utilize
R2988	T4959	T4958	compound	drd2,locus
R2989	T4960	T4961	det	a,impairment
R299	T545	T543	nsubjpass	rules,inverted
R2990	T4817	T4818	dep	that,altered
R2991	T4961	T4952	dobj	impairment,conferred
R2992	T4962	T4961	amod	gross,impairment
R2993	T4963	T4961	amod	olfactory,impairment
R2994	T4818	T4816	relcl	altered,mice
R2995	T4964	T4952	prep	to,conferred
R2996	T4965	T4966	det	the,mice
R2997	T4819	T4818	aux	have,altered
R2998	T4966	T4964	pobj	mice,to
R2999	T4967	T4966	nmod	D2R,mice
R30	T260	T258	punct	", ",cortex
R300	T546	T545	compound	reinforcement,rules
R3000	T4968	T4967	punct	-,D2R
R3001	T4820	T4818	auxpass	been,altered
R3002	T4821	T4818	advmod	genetically,altered
R3003	T4822	T4823	amod	such,lacking
R3004	T4823	T4818	advcl	lacking,altered
R3005	T4969	T4967	punct	/,D2R
R3006	T4824	T4823	mark	that,lacking
R3007	T4970	T4967	punct	-,D2R
R3008	T4971	T4944	punct	.,suggest
R3009	T4825	T4823	nsubj	they,lacking
R301	T547	T543	auxpass	were,inverted
R3010	T4973	T4974	advmod	Rather,argue
R3011	T4826	T4823	aux	are,lacking
R3012	T4975	T4974	punct	", ",argue
R3013	T4827	T4828	nummod	one,alleles
R3014	T4976	T4974	nsubj	we,argue
R3015	T4977	T4978	mark	that,is
R3016	T4978	T4974	ccomp	is,argue
R3017	T4979	T4978	nsubj	this,is
R3018	T4980	T4978	neg	not,is
R3019	T4981	T4978	acomp	likely,is
R302	T548	T524	punct	.,fail
R3020	T4982	T4983	mark	because,learn
R3021	T4828	T4823	dobj	alleles,lacking
R3022	T4983	T4978	advcl	learn,is
R3023	T4829	T4827	cc	or,one
R3024	T4984	T4985	det	the,mice
R3025	T4985	T4983	nsubj	mice,learn
R3026	T4830	T4827	conj	both,one
R3027	T4986	T4985	nmod	D2R,mice
R3028	T4987	T4986	punct	-,D2R
R3029	T4988	T4986	punct	/,D2R
R303	T552	T553	amod	Inbred,mice
R3030	T4831	T4828	amod	functional,alleles
R3031	T4989	T4986	punct	-,D2R
R3032	T4990	T4983	aux	did,learn
R3033	T4991	T4992	aux	to,retrieve
R3034	T4832	T4828	prep	of,alleles
R3035	T4992	T4983	xcomp	retrieve,learn
R3036	T4833	T4834	det	the,receptor
R3037	T4834	T4832	pobj	receptor,of
R3038	T4993	T4994	det	the,pellets
R3039	T4835	T4834	amod	specific,receptor
R304	T553	T557	nsubj	mice,are
R3040	T4994	T4992	dobj	pellets,retrieve
R3041	T4836	T4834	prep	of,receptor
R3042	T4995	T4994	compound	food,pellets
R3043	T4996	T4992	prep	from,retrieve
R3044	T4837	T4836	pobj	interest,of
R3045	T4997	T4998	det	the,dishes
R3046	T4998	T4996	pobj	dishes,from
R3047	T4999	T4983	cc	and,learn
R3048	T4838	T4803	punct	.,argue
R3049	T5000	T5001	advmod	eventually,learned
R305	T554	T555	compound	C57Bl,6J
R3050	T5001	T4983	conj	learned,learn
R3051	T4840	T4841	mark	While,have
R3052	T5002	T5003	aux	to,discriminate
R3053	T5003	T5001	xcomp	discriminate,learned
R3054	T5004	T5003	advmod	accurately,discriminate
R3055	T5005	T5003	dobj	odors,discriminate
R3056	T4841	T4844	advcl	have,revealed
R3057	T5006	T4974	punct	.,argue
R3058	T4842	T4841	nsubj	they,have
R3059	T5008	T5009	amod	Recent,data
R306	T555	T553	compound	6J,mice
R3060	T5009	T5011	nsubj	data,demonstrate
R3061	T5010	T5009	amod	electrophysiological,data
R3062	T4843	T4841	aux	do,have
R3063	T5012	T5013	mark	that,located
R3064	T4845	T4846	poss	their,limitations
R3065	T5013	T5011	ccomp	located,demonstrate
R3066	T5014	T5015	compound	dopamine,D2R's
R3067	T5015	T5013	nsubjpass	D2R's,located
R3068	T5016	T5013	auxpass	are,located
R3069	T5017	T5013	prep	on,located
R307	T556	T555	punct	/,6J
R3070	T5018	T5019	amod	glutamatergic,axons
R3071	T4846	T4841	dobj	limitations,have
R3072	T5019	T5017	pobj	axons,on
R3073	T5020	T5019	amod	terminal,axons
R3074	T5021	T5019	prep	of,axons
R3075	T4847	T4848	punct	(,compensation
R3076	T5022	T5023	amod	olfactory,nerves
R3077	T5023	T5021	pobj	nerves,of
R3078	T5024	T5013	cc	and,located
R3079	T4848	T4846	appos	compensation,limitations
R308	T558	T559	dep	that,develop
R3080	T5025	T5013	conj	depress,located
R3081	T5026	T5027	amod	excitatory,input
R3082	T5027	T5025	dobj	input,depress
R3083	T4849	T4848	advmod	e.g.,compensation
R3084	T5028	T5027	prep	of,input
R3085	T5029	T5030	det	the,nerve
R3086	T4850	T4848	amod	developmental,compensation
R3087	T4851	T4848	cc	and,compensation
R3088	T5030	T5028	pobj	nerve,of
R3089	T4852	T4853	compound	strain,effects
R309	T559	T553	relcl	develop,mice
R3090	T5031	T5030	amod	olfactory,nerve
R3091	T5032	T5027	prep	to,input
R3092	T5033	T5034	det	the,cells
R3093	T4853	T4848	conj	effects,compensation
R3094	T5034	T5032	pobj	cells,to
R3095	T5035	T5034	amod	mitral,cells
R3096	T5036	T5034	prep	of,cells
R3097	T4854	T4848	prep	in,compensation
R3098	T5037	T5038	det	the,bulb
R3099	T5038	T5036	pobj	bulb,of
R31	T261	T258	conj	midbrain,cortex
R310	T560	T559	prep	in,develop
R3100	T5039	T5038	amod	olfactory,bulb
R3101	T4855	T4856	compound	mouse,lines
R3102	T5040	T5041	punct	[,31
R3103	T5041	T5025	parataxis	31,depress
R3104	T5042	T5041	nummod	30,31
R3105	T4856	T4854	pobj	lines,in
R3106	T5043	T5041	punct	",",31
R3107	T5044	T5041	punct	],31
R3108	T5045	T5011	punct	.,demonstrate
R3109	T4857	T4858	neg	not,backcrossed
R311	T561	T562	det	the,absence
R3110	T5047	T5048	advmod	Consequently,suggest
R3111	T4858	T4856	acl	backcrossed,lines
R3112	T5048	T5059	ccomp	suggest,affects
R3113	T5049	T5048	punct	", ",suggest
R3114	T5050	T5051	poss	our,data
R3115	T4859	T4858	advmod	adequately,backcrossed
R3116	T5051	T5048	nsubj	data,suggest
R3117	T5052	T5051	punct	", ",data
R3118	T5053	T5051	cc	and,data
R3119	T5054	T5051	conj	data,data
R312	T562	T560	pobj	absence,in
R3120	T5055	T5054	prep	from,data
R3121	T5056	T5057	amod	other,studies
R3122	T4860	T4858	prep	to,backcrossed
R3123	T5057	T5055	pobj	studies,from
R3124	T5058	T5048	punct	", ",suggest
R3125	T4861	T4862	det	a,strain
R3126	T5060	T5061	mark	that,prevent
R3127	T4862	T4860	pobj	strain,to
R3128	T5061	T5048	ccomp	prevent,suggest
R3129	T5075	T5076	amod	olfactory,stimuli
R313	T563	T562	amod	complete,absence
R3130	T5062	T5063	det	the,lack
R3131	T5063	T5061	nsubj	lack,prevent
R3132	T5064	T5063	amod	complete,lack
R3133	T5065	T5063	prep	of,lack
R3134	T5066	T5065	pobj	D2Rs,of
R3135	T5076	T5074	pobj	stimuli,of
R3136	T5067	T5063	prep	in,lack
R3137	T5068	T5069	det	the,bulb
R3138	T5069	T5067	pobj	bulb,in
R3139	T5077	T5059	punct	;,affects
R314	T564	T562	prep	of,absence
R3140	T5070	T5069	amod	olfactory,bulb
R3141	T5071	T5061	aux	does,prevent
R3142	T5078	T5059	advmod	rather,affects
R3143	T5072	T5061	neg	not,prevent
R3144	T5073	T5061	dobj	transduction,prevent
R3145	T5074	T5073	prep	of,transduction
R3146	T5079	T5059	nsubj	it,affects
R3147	T5080	T5081	det	the,ability
R3148	T5081	T5059	dobj	ability,affects
R3149	T5082	T5083	aux	to,habituate
R315	T565	T566	amod	functional,receptors
R3150	T5083	T5081	acl	habituate,ability
R3151	T5181	T5180	acomp	significant,are
R3152	T5182	T5183	mark	because,respond
R3153	T5084	T5083	punct	", ",habituate
R3154	T5183	T5180	advcl	respond,are
R3155	T5184	T5185	nmod	D2R,mice
R3156	T5185	T5183	nsubj	mice,respond
R3157	T5085	T5083	cc	or,habituate
R3158	T5186	T5184	punct	-,D2R
R3159	T5187	T5184	punct	/,D2R
R316	T566	T564	pobj	receptors,of
R3160	T5188	T5184	punct	-,D2R
R3161	T5086	T5083	conj	tune,habituate
R3162	T5189	T5183	prep	to,respond
R3163	T5190	T5191	compound	food,reinforcers
R3164	T5087	T5086	punct	", ",tune
R3165	T5191	T5189	pobj	reinforcers,to
R3166	T5192	T5183	cc	and,respond
R3167	T5193	T5194	advmod	ultimately,form
R3168	T5088	T5089	amod	olfactory,nerve
R3169	T5194	T5183	conj	form,respond
R317	T567	T568	compound	dopamine,D2
R3170	T5195	T5194	cc	and,form
R3171	T5196	T5194	conj	maintain,form
R3172	T5197	T5198	npadvmod	odor,driven
R3173	T5198	T5200	amod	driven,relationships
R3174	T5199	T5198	punct	-,driven
R3175	T5089	T5090	compound	nerve,activity
R3176	T5200	T5196	dobj	relationships,maintain
R3177	T5201	T5200	nmod	S,relationships
R3178	T5202	T5201	punct	+,S
R3179	T5090	T5086	conj	activity,tune
R318	T568	T566	compound	D2,receptors
R3180	T5203	T5201	punct	/,S
R3181	T5091	T5090	acl	associated,activity
R3182	T5204	T5201	appos	S,S
R3183	T5205	T5204	punct	-,S
R3184	T5206	T5207	punct	(,behavior
R3185	T5207	T5200	appos	behavior,relationships
R3186	T5092	T5091	prep	with,associated
R3187	T5208	T5207	det	a,behavior
R3188	T5209	T5207	amod	putative,behavior
R3189	T5093	T5094	advmod	repeatedly,encountered
R319	T569	T557	acomp	capable,are
R3190	T5210	T5211	npadvmod	D1R,mediated
R3191	T5211	T5207	amod	mediated,behavior
R3192	T5212	T5211	punct	-,mediated
R3193	T5094	T5095	amod	encountered,concentrations
R3194	T5213	T5214	punct	[,6
R3195	T5214	T5196	parataxis	6,maintain
R3196	T5215	T5214	punct	],6
R3197	T5095	T5092	pobj	concentrations,with
R3198	T5216	T5196	punct	),maintain
R3199	T5217	T5218	advmod	just,as
R32	T262	T261	punct	", ",midbrain
R320	T570	T569	prep	of,capable
R3200	T5218	T5183	prep	as,respond
R3201	T5096	T5095	prep	of,concentrations
R3202	T5219	T5220	nmod	D2R,mice
R3203	T5220	T5218	pobj	mice,as
R3204	T5221	T5219	punct	+,D2R
R3205	T5097	T5098	amod	chemical,stimuli
R3206	T5222	T5219	punct	/,D2R
R3207	T5223	T5219	punct	+,D2R
R3208	T5224	T5225	punct	(,targeted
R3209	T5098	T5096	pobj	stimuli,of
R321	T571	T570	pobj	olfaction,of
R3210	T5099	T5100	punct	[,32
R3211	T5225	T5220	parataxis	targeted,mice
R3212	T5226	T5227	det	both,groups
R3213	T5100	T5059	parataxis	32,affects
R3214	T5227	T5228	nsubj	groups,achieved
R3215	T5228	T5225	ccomp	achieved,targeted
R3216	T5229	T5230	punct	≥,80
R3217	T5101	T5100	punct	],32
R3218	T5230	T5231	nummod	80,%
R3219	T5231	T5232	compound	%,accuracy
R322	T572	T557	cc	but,are
R3220	T5232	T5228	dobj	accuracy,achieved
R3221	T5102	T5059	punct	.,affects
R3222	T5233	T5232	compound	discrimination,accuracy
R3223	T5234	T5225	punct	", ",targeted
R3224	T5235	T5236	det	the,D1Rs
R3225	T5236	T5225	nsubjpass	D1Rs,targeted
R3226	T5237	T5236	compound	dopamine,D1Rs
R3227	T5238	T5236	prep	in,D1Rs
R3228	T5104	T5105	det	The,performance
R3229	T5239	T5240	poss	our,mice
R323	T573	T557	conj	display,are
R3230	T5240	T5238	pobj	mice,in
R3231	T5241	T5225	auxpass	were,targeted
R3232	T5242	T5225	neg	not,targeted
R3233	T5105	T5106	nsubj	performance,is
R3234	T5243	T5225	punct	),targeted
R3235	T5244	T5180	punct	.,are
R3236	T5107	T5105	prep	of,performance
R3237	T5246	T5247	det	A,extension
R3238	T5247	T5249	nsubj	extension,be
R3239	T5108	T5109	nmod	D2R,mice
R324	T574	T575	det	an,ability
R3240	T5248	T5247	amod	future,extension
R3241	T5250	T5247	prep	of,extension
R3242	T5109	T5107	pobj	mice,of
R3243	T5251	T5252	det	this,study
R3244	T5252	T5250	pobj	study,of
R3245	T5110	T5108	punct	-,D2R
R3246	T5253	T5249	aux	would,be
R3247	T5254	T5255	aux	to,test
R3248	T5255	T5249	xcomp	test,be
R3249	T5111	T5108	punct	/,D2R
R325	T575	T573	dobj	ability,display
R3250	T5256	T5255	dobj	performance,test
R3251	T5257	T5256	prep	over,performance
R3252	T5258	T5259	det	a,number
R3253	T5112	T5108	punct	-,D2R
R3254	T5259	T5257	pobj	number,over
R3255	T5260	T5259	amod	fixed,number
R3256	T5261	T5259	prep	of,number
R3257	T5113	T5105	prep	during,performance
R3258	T5262	T5261	pobj	trials,of
R3259	T5263	T5255	cc	and,test
R326	T576	T575	amod	impaired,ability
R3260	T5264	T5255	conj	determine,test
R3261	T5114	T5115	compound	reversal,learning
R3262	T5265	T5264	dobj	patterns,determine
R3263	T5266	T5265	prep	of,patterns
R3264	T5267	T5268	compound	error,rates
R3265	T5115	T5113	pobj	learning,during
R3266	T5268	T5266	pobj	rates,of
R3267	T5269	T5264	prep	during,determine
R3268	T5270	T5269	pobj	acquisition,during
R3269	T5116	T5106	acomp	deficient,is
R327	T577	T578	aux	to,acquire
R3270	T5271	T5270	prep	of,acquisition
R3271	T5272	T5273	det	the,tasks
R3272	T5117	T5106	advcl	revealing,is
R3273	T5273	T5271	pobj	tasks,of
R3274	T5274	T5273	nmod	discrimination,tasks
R3275	T5275	T5274	cc	and,discrimination
R3276	T5276	T5274	conj	reversal,discrimination
R3277	T5277	T5273	compound	learning,tasks
R3278	T5278	T5249	punct	.,be
R3279	T5280	T5281	det	This,manipulation
R328	T578	T575	acl	acquire,ability
R3280	T5281	T5282	nsubj	manipulation,control
R3281	T5283	T5282	aux	would,control
R3282	T5284	T5285	det	the,number
R3283	T5118	T5119	det	a,role
R3284	T5285	T5282	dobj	number,control
R3285	T5119	T5117	dobj	role,revealing
R3286	T5120	T5119	prep	for,role
R3287	T5121	T5122	compound	dopamine,D2R
R3288	T5286	T5285	prep	of,number
R3289	T5287	T5286	pobj	errors,of
R329	T579	T580	npadvmod	odor,driven
R3290	T5122	T5123	npadvmod	D2R,mediated
R3291	T5288	T5282	prep	based,control
R3292	T5289	T5288	prep	on,based
R3293	T5290	T5289	pobj	trials,on
R3294	T5123	T5125	amod	mediated,signaling
R3295	T5291	T5290	acl	performed,trials
R3296	T5292	T5293	aux	to,determine
R3297	T5293	T5282	advcl	determine,control
R3298	T5124	T5123	punct	-,mediated
R3299	T5294	T5295	mark	if,is
R33	T263	T261	cc	and,midbrain
R330	T580	T582	amod	driven,contingencies
R3300	T5295	T5293	ccomp	is,determine
R3301	T5296	T5297	det	the,difference
R3302	T5125	T5120	pobj	signaling,for
R3303	T5297	T5295	nsubj	difference,is
R3304	T5298	T5297	amod	apparent,difference
R3305	T5299	T5297	prep	in,difference
R3306	T5126	T5119	prep	in,role
R3307	T5300	T5301	amod	absolute,number
R3308	T5301	T5299	pobj	number,in
R3309	T5302	T5301	prep	of,number
R331	T581	T580	punct	-,driven
R3310	T5127	T5126	pobj	tasks,in
R3311	T5303	T5302	pobj	errors,of
R3312	T5304	T5297	acl	demonstrated,difference
R3313	T5305	T5304	agent	by,demonstrated
R3314	T5128	T5127	acl	requiring,tasks
R3315	T5306	T5307	det	the,mice
R3316	T5307	T5305	pobj	mice,by
R3317	T5308	T5307	amod	mutant,mice
R3318	T5129	T5130	amod	behavioral,flexibility
R3319	T5309	T5310	punct	(,deficit
R332	T582	T578	dobj	contingencies,acquire
R3320	T5310	T5297	appos	deficit,difference
R3321	T5311	T5310	det	the,deficit
R3322	T5130	T5128	dobj	flexibility,requiring
R3323	T5312	T5310	amod	putative,deficit
R3324	T5313	T5310	compound	performance,deficit
R3325	T5314	T5310	punct	),deficit
R3326	T5315	T5316	advmod	simply,reflection
R3327	T5316	T5295	attr	reflection,is
R3328	T5317	T5316	det	a,reflection
R3329	T5132	T5133	amod	Perseverative,patterns
R333	T583	T582	compound	reinforcement,contingencies
R3330	T5318	T5316	prep	of,reflection
R3331	T5319	T5320	amod	extra,trials
R3332	T5320	T5318	pobj	trials,of
R3333	T5321	T5282	punct	.,control
R3334	T5133	T5135	nsubj	patterns,characterized
R3335	T5323	T5324	advmod	Nonetheless,argues
R3336	T5134	T5133	amod	behavioral,patterns
R3337	T5136	T5137	det	the,mice
R3338	T5325	T5324	punct	", ",argues
R3339	T5326	T5327	det	the,inability
R334	T584	T557	punct	.,are
R3340	T5137	T5135	dobj	mice,characterized
R3341	T5327	T5324	nsubj	inability,argues
R3342	T5138	T5137	nmod	D2R,mice
R3343	T5328	T5327	prep	of,inability
R3344	T5329	T5330	nmod	D2R,mice
R3345	T5330	T5328	pobj	mice,of
R3346	T5331	T5329	punct	-,D2R
R3347	T5139	T5138	punct	-,D2R
R3348	T5332	T5329	punct	/,D2R
R3349	T5333	T5329	punct	-,D2R
R335	T586	T587	advmod	Furthermore,is
R3350	T5140	T5138	punct	/,D2R
R3351	T5334	T5335	aux	to,disengage
R3352	T5335	T5327	acl	disengage,inability
R3353	T5336	T5335	prep	from,disengage
R3354	T5141	T5138	punct	-,D2R
R3355	T5337	T5338	advmod	previously,established
R3356	T5338	T5339	amod	established,contingencies
R3357	T5142	T5137	amod	relative,mice
R3358	T5339	T5336	pobj	contingencies,from
R3359	T5340	T5339	nmod	S,contingencies
R336	T588	T587	punct	", ",is
R3360	T5341	T5340	punct	+,S
R3361	T5342	T5340	punct	/,S
R3362	T5143	T5142	prep	to,relative
R3363	T5343	T5340	appos	S,S
R3364	T5344	T5343	punct	-,S
R3365	T5144	T5145	nmod	D2R,mice
R3366	T5345	T5346	punct	(,Fig.
R3367	T5346	T5327	parataxis	Fig.,inability
R3368	T5347	T5346	advcl	responding,Fig.
R3369	T5145	T5143	pobj	mice,to
R337	T589	T590	det	the,ability
R3370	T5348	T5347	prep	to,responding
R3371	T5349	T5350	det	a,stimulus
R3372	T5350	T5348	pobj	stimulus,to
R3373	T5146	T5144	punct	+,D2R
R3374	T5351	T5350	amod	discriminative,stimulus
R3375	T5352	T5346	punct	;,Fig.
R3376	T5353	T5346	nummod	4,Fig.
R3377	T5147	T5144	punct	/,D2R
R3378	T5354	T5346	punct	),Fig.
R3379	T5355	T5324	advmod	strongly,argues
R338	T590	T587	nsubj	ability,is
R3380	T5356	T5357	mark	that,modulates
R3381	T5357	T5324	ccomp	modulates,argues
R3382	T5358	T5359	amod	mesolimbic,dopamine
R3383	T5359	T5357	nsubj	dopamine,modulates
R3384	T5148	T5144	punct	+,D2R
R3385	T5360	T5359	punct	", ",dopamine
R3386	T5361	T5359	cc	and,dopamine
R3387	T5362	T5363	prep	in,signaling
R3388	T5149	T5135	prep	during,characterized
R3389	T5363	T5359	conj	signaling,dopamine
R339	T591	T590	prep	of,ability
R3390	T5364	T5362	amod	particular,in
R3391	T5365	T5366	compound	dopamine,D2R
R3392	T5150	T5151	compound	reversal,sessions
R3393	T5366	T5367	npadvmod	D2R,mediated
R3394	T5151	T5149	pobj	sessions,during
R3395	T5367	T5363	amod	mediated,signaling
R3396	T5368	T5367	punct	-,mediated
R3397	T5369	T5357	punct	", ",modulates
R3398	T5152	T5151	compound	learning,sessions
R3399	T5370	T5371	det	the,process
R34	T264	T261	conj	striatum,midbrain
R340	T592	T593	compound	dopamine,receptor
R3400	T5371	T5357	dobj	process,modulates
R3401	T5372	T5371	prep	of,process
R3402	T5153	T5154	punct	(,Figure
R3403	T5373	T5372	pcomp	alerting,of
R3404	T5374	T5375	det	the,subject
R3405	T5154	T5135	parataxis	Figure,characterized
R3406	T5155	T5154	nummod	4,Figure
R3407	T5375	T5373	dobj	subject,alerting
R3408	T5156	T5154	punct	),Figure
R3409	T5376	T5377	mark	that,associated
R341	T593	T595	npadvmod	receptor,deficient
R3410	T5377	T5373	ccomp	associated,alerting
R3411	T5157	T5135	punct	", ",characterized
R3412	T5378	T5379	amod	familiar,contingencies
R3413	T5379	T5377	nsubjpass	contingencies,associated
R3414	T5380	T5377	auxpass	are,associated
R3415	T5158	T5135	conj	manifested,characterized
R3416	T5381	T5377	advmod	now,associated
R3417	T5382	T5383	amod	unexpected,consequences
R3418	T5383	T5377	dep	consequences,associated
R3419	T5159	T5158	prep	during,manifested
R342	T594	T593	compound	D2,receptor
R3420	T5384	T5324	punct	.,argues
R3421	T5386	T5387	nsubj	Schultz,demonstrated
R3422	T5160	T5161	amod	early,trials
R3423	T5388	T5386	cc	and,Schultz
R3424	T5161	T5159	pobj	trials,during
R3425	T5389	T5386	conj	colleagues,Schultz
R3426	T5390	T5387	aux	have,demonstrated
R3427	T5391	T5392	mark	that,display
R3428	T5162	T5161	compound	reversal,trials
R3429	T5163	T5164	punct	(,Figure
R343	T595	T596	amod	deficient,mice
R3430	T5164	T5159	parataxis	Figure,during
R3431	T5392	T5387	ccomp	display,demonstrated
R3432	T5393	T5394	compound	dopamine,cells
R3433	T5394	T5392	nsubj	cells,display
R3434	T5165	T5164	nummod	6,Figure
R3435	T5395	T5396	amod	consistent,patterns
R3436	T5396	T5392	dobj	patterns,display
R3437	T5397	T5398	amod	tonic,firing
R3438	T5166	T5164	punct	),Figure
R3439	T5398	T5396	compound	firing,patterns
R344	T596	T591	pobj	mice,of
R3440	T5399	T5392	prep	during,display
R3441	T5400	T5399	pobj	maintenance,during
R3442	T5167	T5158	cc	and,manifested
R3443	T5401	T5400	prep	of,maintenance
R3444	T5402	T5403	amod	associative,learning
R3445	T5403	T5404	compound	learning,tasks
R3446	T5168	T5158	conj	persisted,manifested
R3447	T5404	T5401	pobj	tasks,of
R3448	T5405	T5406	punct	[,33
R3449	T5406	T5387	parataxis	33,demonstrated
R345	T597	T598	aux	to,adjust
R3450	T5169	T5168	prep	across,persisted
R3451	T5407	T5406	punct	],33
R3452	T5170	T5171	amod	several,sessions
R3453	T5171	T5169	pobj	sessions,across
R3454	T5408	T5387	punct	.,demonstrated
R3455	T5172	T5173	punct	(,Figure
R3456	T5410	T5411	advmod	However,occurs
R3457	T5173	T5168	parataxis	Figure,persisted
R3458	T5412	T5411	punct	", ",occurs
R3459	T5413	T5414	amod	phasic,activity
R346	T598	T590	acl	adjust,ability
R3460	T5414	T5411	nsubj	activity,occurs
R3461	T5174	T5173	nummod	7,Figure
R3462	T5415	T5414	compound	burst,activity
R3463	T5416	T5414	prep	of,activity
R3464	T5417	T5418	amod	dopaminergic,cells
R3465	T5175	T5173	punct	),Figure
R3466	T5418	T5416	pobj	cells,of
R3467	T5176	T5135	punct	.,characterized
R3468	T5419	T5420	advmod	when,transpire
R3469	T5420	T5411	advcl	transpire,occurs
R347	T599	T600	poss	their,responding
R3470	T5421	T5420	nsubj	discrepancies,transpire
R3471	T5178	T5179	det	These,findings
R3472	T5422	T5421	prep	between,discrepancies
R3473	T5423	T5424	amod	predicted,contingencies
R3474	T5424	T5422	pobj	contingencies,between
R3475	T5425	T5423	cc	and,predicted
R3476	T5179	T5180	nsubj	findings,are
R3477	T5426	T5423	conj	actual,predicted
R3478	T5427	T5424	compound	reinforcement,contingencies
R3479	T5498	T5497	compound	dopamine,D2R
R348	T600	T598	dobj	responding,adjust
R3480	T5428	T5429	punct	[,14
R3481	T5429	T5411	parataxis	14,occurs
R3482	T5430	T5429	punct	],14
R3483	T5431	T5411	punct	.,occurs
R3484	T5433	T5434	det	This,increase
R3485	T5499	T5495	aux	might,be
R3486	T5434	T5436	nsubjpass	increase,referred
R3487	T5435	T5434	amod	robust,increase
R3488	T5500	T5495	prep	in,be
R3489	T5437	T5434	prep	of,increase
R349	T601	T600	prep	to,responding
R3490	T5438	T5439	amod	dopaminergic,activation
R3491	T5439	T5437	pobj	activation,of
R3492	T5501	T5500	pobj	fact,in
R3493	T5440	T5439	compound	cell,activation
R3494	T5441	T5434	prep	in,increase
R3495	T5442	T5441	pobj	response,in
R3496	T5502	T5503	det	the,point
R3497	T5443	T5442	prep	to,response
R3498	T5444	T5445	amod	unpredicted,outcomes
R3499	T5445	T5443	pobj	outcomes,to
R35	T265	T252	acomp	essential,is
R350	T602	T603	det	a,stimulus
R3500	T5503	T5495	attr	point,be
R3501	T5446	T5436	aux	has,referred
R3502	T5447	T5436	auxpass	been,referred
R3503	T5448	T5436	prep	to,referred
R3504	T5504	T5503	amod	focal,point
R3505	T5449	T5436	prep	as,referred
R3506	T5450	T5451	det	an,signal
R3507	T5505	T5503	prep	of,point
R3508	T5451	T5449	pobj	signal,as
R3509	T5452	T5451	punct	"""",signal
R351	T603	T601	pobj	stimulus,to
R3510	T5453	T5451	nmod	error,signal
R3511	T5506	T5507	det	this,cascade
R3512	T5454	T5451	punct	"""",signal
R3513	T5455	T5456	punct	[,14
R3514	T5456	T5436	parataxis	14,referred
R3515	T5507	T5505	pobj	cascade,of
R3516	T5457	T5456	punct	],14
R3517	T5458	T5436	punct	.,referred
R3518	T5508	T5509	npadvmod	error,signaling
R3519	T5460	T5461	prep	To,identified
R352	T604	T605	advmod	previously,reinforced
R3520	T5509	T5507	amod	signaling,cascade
R3521	T5462	T5460	pobj	date,To
R3522	T5463	T5461	punct	", ",identified
R3523	T5464	T5465	det	the,basis
R3524	T5510	T5509	punct	-,signaling
R3525	T5465	T5461	nsubjpass	basis,identified
R3526	T5466	T5465	amod	molecular,basis
R3527	T5467	T5465	prep	of,basis
R3528	T5511	T5478	punct	.,suggests
R3529	T5468	T5469	det	this,signal
R353	T605	T603	amod	reinforced,stimulus
R3530	T5469	T5467	pobj	signal,of
R3531	T5513	T5514	amod	Electrophysiological,data
R3532	T5470	T5469	compound	error,signal
R3533	T5471	T5461	aux	has,identified
R3534	T5472	T5461	neg	not,identified
R3535	T5473	T5461	auxpass	been,identified
R3536	T5474	T5461	punct	.,identified
R3537	T5476	T5477	det	The,inability
R3538	T5514	T5515	nsubj	data,support
R3539	T5477	T5478	nsubj	inability,suggests
R354	T606	T607	advmod	when,encountered
R3540	T5479	T5477	prep	of,inability
R3541	T5516	T5515	advmod	further,support
R3542	T5480	T5481	det	the,mice
R3543	T5481	T5479	pobj	mice,of
R3544	T5482	T5481	nmod	D2R,mice
R3545	T5483	T5482	punct	-,D2R
R3546	T5517	T5518	det	the,hypothesis
R3547	T5484	T5482	punct	/,D2R
R3548	T5485	T5482	punct	-,D2R
R3549	T5518	T5515	dobj	hypothesis,support
R355	T607	T598	advcl	encountered,adjust
R3550	T5486	T5487	aux	to,desist
R3551	T5487	T5477	acl	desist,inability
R3552	T5488	T5487	xcomp	responding,desist
R3553	T5519	T5520	mark	that,tunes
R3554	T5489	T5488	prep	to,responding
R3555	T5490	T5491	det	a,stimulus
R3556	T5491	T5489	pobj	stimulus,to
R3557	T5520	T5518	acl	tunes,hypothesis
R3558	T5492	T5493	advmod	previously,reinforced
R3559	T5493	T5491	amod	reinforced,stimulus
R356	T608	T609	amod	unexpected,outcomes
R3560	T5494	T5495	mark	that,be
R3561	T5521	T5520	nsubj	signaling,tunes
R3562	T5522	T5521	acl	mediated,signaling
R3563	T5495	T5478	ccomp	be,suggests
R3564	T5523	T5522	agent	by,mediated
R3565	T5496	T5497	det	the,D2R
R3566	T5497	T5495	nsubj	D2R,be
R3567	T5524	T5525	compound	dopamine,D2Rs
R3568	T5525	T5523	pobj	D2Rs,by
R3569	T5526	T5527	npadvmod	D1R,mediated
R357	T609	T607	nsubjpass	outcomes,encountered
R3570	T5527	T5529	amod	mediated,output
R3571	T5604	T5605	nsubj	Carlsson,speculated
R3572	T5528	T5527	punct	-,mediated
R3573	T5606	T5604	cc	and,Carlsson
R3574	T5607	T5604	conj	colleagues,Carlsson
R3575	T5529	T5520	dobj	output,tunes
R3576	T5608	T5609	punct	[,35
R3577	T5609	T5607	parataxis	35,colleagues
R3578	T5610	T5609	punct	],35
R3579	T5530	T5529	amod	mesocorticolimbic,output
R358	T610	T607	auxpass	are,encountered
R3580	T5611	T5605	aux	have,speculated
R3581	T5612	T5613	mark	that,serves
R3582	T5613	T5605	ccomp	serves,speculated
R3583	T5531	T5515	punct	.,support
R3584	T5614	T5615	compound	dopamine,D2R
R3585	T5615	T5616	compound	D2R,stimulation
R3586	T5616	T5613	nsubj	stimulation,serves
R3587	T5617	T5616	prep	in,stimulation
R3588	T5618	T5619	det	the,striatum
R3589	T5619	T5617	pobj	striatum,in
R359	T611	T612	advmod	significantly,impaired
R3590	T5533	T5534	nsubj	Calabresi,demonstrated
R3591	T5620	T5621	aux	to,brake
R3592	T5621	T5613	xcomp	brake,serves
R3593	T5622	T5621	punct	"""",brake
R3594	T5623	T5621	punct	"""",brake
R3595	T5535	T5536	advmod	et,al.
R3596	T5624	T5621	cc	or,brake
R3597	T5625	T5621	conj	diminish,brake
R3598	T5626	T5627	amod	excitatory,signaling
R3599	T5627	T5625	dobj	signaling,diminish
R36	T266	T252	prep	for,is
R360	T612	T587	acomp	impaired,is
R3600	T5536	T5533	advmod	al.,Calabresi
R3601	T5628	T5627	amod	corticostriatal,signaling
R3602	T5629	T5627	cc	and,signaling
R3603	T5630	T5627	conj	plasticity,signaling
R3604	T5537	T5538	punct	[,34
R3605	T5631	T5605	punct	.,speculated
R3606	T5538	T5533	parataxis	34,Calabresi
R3607	T5633	T5634	advmod	Indeed,associated
R3608	T5635	T5634	punct	", ",associated
R3609	T5539	T5538	punct	],34
R361	T613	T587	punct	.,is
R3610	T5636	T5637	amod	perseverative,behavior
R3611	T5637	T5634	nsubjpass	behavior,associated
R3612	T5638	T5634	auxpass	is,associated
R3613	T5540	T5541	mark	that,associated
R3614	T5639	T5634	prep	with,associated
R3615	T5640	T5641	amod	over,activity
R3616	T5541	T5534	ccomp	associated,demonstrated
R3617	T5641	T5639	pobj	activity,with
R3618	T5642	T5641	prep	of,activity
R3619	T5542	T5543	amod	tetanic,stimulation
R362	T615	T616	det	These,findings
R3620	T5643	T5644	det	the,striatum
R3621	T5644	T5642	pobj	striatum,of
R3622	T5645	T5644	amod	dorsal,striatum
R3623	T5543	T5541	nsubjpass	stimulation,associated
R3624	T5646	T5641	prep	in,activity
R3625	T5647	T5646	pobj	rodents,in
R3626	T5544	T5543	prep	of,stimulation
R3627	T5648	T5649	punct	[,36
R3628	T5649	T5641	parataxis	36,activity
R3629	T5650	T5649	punct	],36
R363	T616	T617	nsubj	findings,suggest
R3630	T5545	T5546	amod	dorsal,slices
R3631	T5651	T5641	cc	and,activity
R3632	T5652	T5653	amod	over,activity
R3633	T5653	T5641	conj	activity,activity
R3634	T5546	T5544	pobj	slices,of
R3635	T5654	T5653	prep	of,activity
R3636	T5655	T5656	det	the,caudate
R3637	T5547	T5546	compound	striatum,slices
R3638	T5656	T5654	pobj	caudate,of
R3639	T5657	T5653	prep	in,activity
R364	T618	T619	mark	that,is
R3640	T5658	T5657	pobj	patients,in
R3641	T5659	T5658	prep	with,patients
R3642	T5660	T5659	pobj	ADHD,with
R3643	T5661	T5662	punct	[,37
R3644	T5548	T5546	acl	prepared,slices
R3645	T5662	T5653	parataxis	37,activity
R3646	T5663	T5662	punct	],37
R3647	T5664	T5634	cc	and,associated
R3648	T5549	T5548	prep	from,prepared
R3649	T5665	T5666	det	a,correlation
R365	T619	T617	ccomp	is,suggest
R3650	T5666	T5669	nsubjpass	correlation,reported
R3651	T5667	T5666	amod	strong,correlation
R3652	T5550	T5551	nmod	D2R,mice
R3653	T5668	T5666	amod	inverse,correlation
R3654	T5551	T5549	pobj	mice,from
R3655	T5552	T5550	punct	-,D2R
R3656	T5669	T5634	conj	reported,associated
R3657	T5670	T5666	prep	of,correlation
R3658	T5553	T5550	punct	/,D2R
R3659	T5671	T5672	compound	D2R,binding
R366	T620	T619	nsubj	signaling,is
R3660	T5672	T5670	pobj	binding,of
R3661	T5673	T5666	prep	with,correlation
R3662	T5554	T5550	punct	-,D2R
R3663	T5674	T5675	amod	compulsive,behavior
R3664	T5675	T5673	pobj	behavior,with
R3665	T5555	T5541	auxpass	is,associated
R3666	T5676	T5669	aux	has,reported
R3667	T5677	T5669	auxpass	been,reported
R3668	T5556	T5541	prep	with,associated
R3669	T5678	T5679	punct	[,22
R367	T621	T620	acl	mediated,signaling
R3670	T5679	T5669	parataxis	22,reported
R3671	T5557	T5558	amod	enhanced,EPSP
R3672	T5680	T5679	punct	],22
R3673	T5681	T5669	punct	.,reported
R3674	T5558	T5556	pobj	EPSP,with
R3675	T5683	T5684	advmod	Importantly,indicate
R3676	T5559	T5558	cc	and,EPSP
R3677	T5685	T5684	punct	", ",indicate
R3678	T5686	T5687	poss	our,data
R3679	T5560	T5561	prep	as,efficacy
R368	T622	T621	agent	by,mediated
R3680	T5687	T5684	nsubj	data,indicate
R3681	T5688	T5689	mark	that,are
R3682	T5561	T5558	conj	efficacy,EPSP
R3683	T5689	T5684	ccomp	are,indicate
R3684	T5690	T5691	det	the,performances
R3685	T5691	T5689	nsubj	performances,are
R3686	T5562	T5563	det	a,result
R3687	T5692	T5691	amod	poor,performances
R3688	T5693	T5691	acl	displayed,performances
R3689	T5694	T5693	agent	by,displayed
R369	T623	T624	det	the,receptor
R3690	T5695	T5696	det	the,mice
R3691	T5696	T5694	pobj	mice,by
R3692	T5563	T5560	pobj	result,as
R3693	T5697	T5696	nmod	D2R,mice
R3694	T5698	T5697	punct	-,D2R
R3695	T5564	T5561	amod	increased,efficacy
R3696	T5699	T5697	punct	/,D2R
R3697	T5700	T5697	punct	-,D2R
R3698	T5701	T5689	attr	manifestations,are
R3699	T5565	T5561	amod	striatal,efficacy
R37	T267	T266	pcomp	processing,for
R370	T624	T622	pobj	receptor,by
R3700	T5702	T5701	prep	of,manifestations
R3701	T5703	T5704	compound	reversal,learning
R3702	T5704	T5705	compound	learning,deficits
R3703	T5566	T5561	amod	synaptic,efficacy
R3704	T5705	T5702	pobj	deficits,of
R3705	T5706	T5701	cc	and,manifestations
R3706	T5707	T5706	neg	not,and
R3707	T5567	T5534	punct	.,demonstrated
R3708	T5708	T5709	amod	gross,impairments
R3709	T5709	T5701	conj	impairments,manifestations
R371	T625	T624	compound	dopamine,receptor
R3710	T5569	T5570	prep	In,resulted
R3711	T5571	T5569	pobj	contrast,In
R3712	T5710	T5709	amod	motivational,impairments
R3713	T5711	T5710	cc	or,motivational
R3714	T5572	T5570	punct	", ",resulted
R3715	T5712	T5710	conj	sensory,motivational
R3716	T5713	T5684	punct	.,indicate
R3717	T5573	T5570	nsubj	stimulation,resulted
R3718	T5715	T5716	nsubj	We,argue
R3719	T5574	T5573	prep	of,stimulation
R372	T626	T624	compound	D2,receptor
R3720	T5717	T5716	advmod	therefore,argue
R3721	T5718	T5719	mark	that,participate
R3722	T5719	T5716	ccomp	participate,argue
R3723	T5575	T5576	amod	dorsal,slices
R3724	T5720	T5719	nsubj	D2Rs,participate
R3725	T5721	T5719	prep	in,participate
R3726	T5576	T5574	pobj	slices,of
R3727	T5722	T5721	pcomp	signaling,in
R3728	T5723	T5722	cc	or,signaling
R3729	T5724	T5722	conj	alerting,signaling
R373	T627	T619	acomp	important,is
R3730	T5577	T5576	compound	striatum,slices
R3731	T5725	T5726	det	the,organism
R3732	T5726	T5724	dobj	organism,alerting
R3733	T5727	T5726	prep	of,organism
R3734	T5578	T5573	prep	from,stimulation
R3735	T5728	T5729	compound	learning,contingency
R3736	T5729	T5730	compound	contingency,changes
R3737	T5730	T5727	pobj	changes,of
R3738	T5579	T5580	amod	wild,type
R3739	T5731	T5724	prep	during,alerting
R374	T628	T619	prep	for,is
R3740	T5732	T5733	compound	reversal,learning
R3741	T5580	T5582	compound	type,mice
R3742	T5733	T5731	pobj	learning,during
R3743	T5734	T5719	cc	and,participate
R3744	T5735	T5719	conj	sculpt,participate
R3745	T5736	T5737	amod	ongoing,behavior
R3746	T5737	T5735	dobj	behavior,sculpt
R3747	T5738	T5739	npadvmod	goal,directed
R3748	T5581	T5580	punct	-,type
R3749	T5739	T5737	amod	directed,behavior
R375	T629	T628	pcomp	regulating,for
R3750	T5740	T5739	punct	-,directed
R3751	T5741	T5716	punct	.,argue
R3752	T5582	T5578	pobj	mice,from
R3753	T5583	T5570	prep	in,resulted
R3754	T5584	T5585	compound	IPSP,activity
R3755	T5585	T5583	pobj	activity,in
R3756	T5586	T5585	punct	", ",activity
R3757	T5587	T5588	amod	long,term
R3758	T5588	T5590	compound	term,depression
R3759	T5589	T5588	punct	-,term
R376	T630	T631	amod	associative,learning
R3760	T5590	T5585	conj	depression,activity
R3761	T5591	T5590	punct	", ",depression
R3762	T5592	T5590	cc	and,depression
R3763	T5593	T5594	amod	decreased,activity
R3764	T5594	T5590	conj	activity,depression
R3765	T5595	T5594	amod	neuronal,activity
R3766	T5596	T5594	prep	of,activity
R3767	T5597	T5598	amod	striatal,efferents
R3768	T5598	T5596	pobj	efferents,of
R3769	T5599	T5600	punct	[,34
R377	T631	T629	dobj	learning,regulating
R3770	T5600	T5570	parataxis	34,resulted
R3771	T5601	T5600	punct	],34
R3772	T5602	T5570	punct	.,resulted
R3775	T5854	T5855	det	This,study
R3776	T5855	T5856	nsubj	study,demonstrates
R3777	T5857	T5858	mark	that,mediate
R3778	T5858	T5856	ccomp	mediate,demonstrates
R3779	T5859	T5858	nsubj	signaling,mediate
R378	T632	T630	cc	and,associative
R3780	T5860	T5859	prep	by,signaling
R3781	T5861	T5862	compound	dopamine,D2Rs
R3782	T5862	T5860	pobj	D2Rs,by
R3783	T5863	T5858	aux	does,mediate
R3784	T5864	T5858	neg	not,mediate
R3785	T5865	T5866	det	the,value
R3786	T5866	T5858	dobj	value,mediate
R3787	T5867	T5866	amod	hedonic,value
R3788	T5868	T5866	prep	of,value
R3789	T5869	T5868	pobj	reinforcers,of
R379	T633	T630	conj	reversal,associative
R3790	T5870	T5856	punct	", ",demonstrates
R3791	T5871	T5856	advcl	supporting,demonstrates
R3792	T5872	T5871	cc	and,supporting
R3793	T5873	T5871	conj	refining,supporting
R3794	T5874	T5875	amod	earlier,findings
R3795	T5875	T5873	dobj	findings,refining
R3796	T5876	T5877	punct	[,2
R3797	T5877	T5856	parataxis	2,demonstrates
R3798	T5878	T5877	nummod	1,2
R3799	T5879	T5877	punct	",",2
R38	T268	T267	cc	and,processing
R380	T634	T619	cc	and,is
R3800	T5880	T5877	punct	],2
R3801	T5881	T5856	punct	.,demonstrates
R3802	T5883	T5884	advmod	However,demonstrated
R3803	T5885	T5884	punct	", ",demonstrated
R3804	T5886	T5884	nsubj	mice,demonstrated
R3805	T5887	T5888	advmod	completely,deficient
R3806	T5888	T5886	amod	deficient,mice
R3807	T5889	T5888	prep	in,deficient
R3808	T5890	T5889	pobj	D2Rs,in
R3809	T5891	T5892	amod	disrupted,acquisition
R381	T635	T636	aux	may,have
R3810	T5892	T5884	dobj	acquisition,demonstrated
R3811	T5893	T5892	prep	of,acquisition
R3812	T5894	T5895	amod	discriminative,stimulus
R3813	T5895	T5896	compound	stimulus,relationships
R3814	T5896	T5893	pobj	relationships,of
R3815	T5897	T5892	cc	and,acquisition
R3816	T5898	T5899	det	an,ability
R3817	T5899	T5892	conj	ability,acquisition
R3818	T5900	T5899	amod	impaired,ability
R3819	T5901	T5902	aux	to,recognize
R382	T636	T619	conj	have,is
R3820	T5902	T5899	acl	recognize,ability
R3821	T5903	T5902	dobj	changes,recognize
R3822	T5904	T5903	prep	in,changes
R3823	T5905	T5906	amod	behavioral,determinants
R3824	T5906	T5904	pobj	determinants,in
R3825	T5907	T5884	punct	.,demonstrated
R3826	T5909	T5910	advmod	Therefore,suggest
R3827	T5911	T5910	punct	", ",suggest
R3828	T5912	T5910	nsubj	we,suggest
R3829	T5913	T5914	mark	that,involve
R383	T637	T636	dobj	implications,have
R3830	T5914	T5910	ccomp	involve,suggest
R3831	T5915	T5914	prep	during,involve
R3832	T5916	T5917	amod	associative,learning
R3833	T5917	T5915	pobj	learning,during
R3834	T5918	T5915	cc	or,during
R3835	T5919	T5920	advmod	when,modified
R3836	T5920	T5915	conj	modified,during
R3837	T5921	T5922	amod	unexpected,outcomes
R3838	T5922	T5920	nsubjpass	outcomes,modified
R3839	T5923	T5922	compound	reinforcement,outcomes
R384	T638	T636	prep	for,have
R3840	T5924	T5920	auxpass	are,modified
R3841	T5925	T5926	punct	(,learning
R3842	T5926	T5920	parataxis	learning,modified
R3843	T5927	T5926	compound	reversal,learning
R3844	T5928	T5926	punct	),learning
R3845	T5929	T5930	npadvmod	dopamine,driven
R3846	T5930	T5932	amod	driven,impulses
R3847	T5931	T5930	punct	-,driven
R3848	T5932	T5914	nsubj	impulses,involve
R3849	T5933	T5932	compound	reinforcement,impulses
R385	T639	T640	det	the,treatment
R3850	T5934	T5914	dobj	signaling,involve
R3851	T5935	T5934	acl	mediated,signaling
R3852	T5936	T5935	agent	by,mediated
R3853	T5937	T5938	compound	dopamine,D2Rs
R3854	T5938	T5936	pobj	D2Rs,by
R3855	T5939	T5910	punct	.,suggest
R3856	T5941	T5942	prep	In,receive
R3857	T5943	T5944	det	the,course
R3858	T5944	T5941	pobj	course,In
R3859	T5945	T5944	prep	of,course
R386	T640	T638	pobj	treatment,for
R3860	T5946	T5947	amod	associative,learning
R3861	T5947	T5945	pobj	learning,of
R3862	T5948	T5942	punct	", ",receive
R3863	T5949	T5950	amod	striatal,synapses
R3864	T5950	T5942	nsubj	synapses,receive
R3865	T5951	T5952	punct	[,38
R3866	T5952	T5950	parataxis	38,synapses
R3867	T5953	T5952	punct	],38
R3868	T5954	T5955	npadvmod	experience,driven
R3869	T5955	T5957	amod	driven,gain
R387	T641	T640	prep	of,treatment
R3870	T5956	T5955	punct	-,driven
R3871	T5957	T5942	dobj	gain,receive
R3872	T5958	T5959	punct	[,7
R3873	T5959	T5942	parataxis	7,receive
R3874	T5960	T5959	punct	],7
R3875	T5961	T5942	punct	", ",receive
R3876	T5962	T5963	advmod	thus,permitting
R3877	T5963	T5942	advcl	permitting,receive
R3878	T5964	T5965	advmod	newly,established
R3879	T5965	T5966	amod	established,mediated
R388	T642	T643	amod	human,disorders
R3880	T5966	T5969	amod	mediated,signals
R3881	T5967	T5966	npadvmod	reinforcement,mediated
R3882	T5968	T5966	punct	-,mediated
R3883	T5969	T5963	dobj	signals,permitting
R3884	T5970	T5971	aux	to,traverse
R3885	T5971	T5963	xcomp	traverse,permitting
R3886	T5972	T5973	amod	ascending,efferents
R3887	T5973	T5971	dobj	efferents,traverse
R3888	T5974	T5975	advmod	en,to
R3889	T5975	T5971	prep	to,traverse
R389	T643	T641	pobj	disorders,of
R3890	T5976	T5975	advmod	route,to
R3891	T5977	T5978	det	the,cortex
R3892	T5978	T5975	pobj	cortex,to
R3893	T5979	T5978	amod	frontal,cortex
R3894	T5980	T5971	punct	", ",traverse
R3895	T5981	T5971	advcl	completing,traverse
R3896	T5982	T5983	det	a,circuit
R3897	T5983	T5981	dobj	circuit,completing
R3898	T5984	T5983	amod	functional,circuit
R3899	T5985	T5986	amod	limbic,motor
R39	T269	T267	conj	integrating,processing
R390	T644	T643	compound	attention,disorders
R3900	T5986	T5983	amod	motor,circuit
R3901	T5987	T5986	punct	/,motor
R3902	T5988	T5989	punct	[,39
R3903	T5989	T5963	parataxis	39,permitting
R3904	T5990	T5991	punct	-,41
R3905	T5991	T5989	prep	41,39
R3906	T5992	T5989	punct	],39
R3907	T5993	T5942	punct	.,receive
R3908	T5995	T5996	advmod	Possibly,prevents
R3909	T5997	T5996	punct	", ",prevents
R391	T645	T617	punct	.,suggest
R3910	T5998	T5999	det	the,lack
R3911	T5999	T5996	nsubj	lack,prevents
R3912	T6000	T5999	prep	of,lack
R3913	T6001	T6002	compound	dopamine,D2R
R3914	T6002	T6003	npadvmod	D2R,mediated
R3915	T6003	T6005	amod	mediated,signaling
R3916	T6004	T6003	punct	-,mediated
R3917	T6005	T6000	pobj	signaling,of
R3918	T6006	T5996	dobj	refinement,prevents
R3919	T6007	T6006	prep	of,refinement
R392	T229	T230	compound	Dopamine,D2
R3920	T6008	T6009	det	the,circuits
R3921	T6009	T6007	pobj	circuits,of
R3922	T6010	T6009	amod	corticostriatal,circuits
R3923	T6011	T6009	compound	reinforcement,circuits
R3924	T6012	T6006	prep	in,refinement
R3925	T6013	T6014	det	the,brains
R3926	T6014	T6012	pobj	brains,in
R3927	T6015	T6014	prep	of,brains
R3928	T6016	T6017	det	the,mice
R3929	T6017	T6015	pobj	mice,of
R3930	T6018	T6017	nmod	D2R,mice
R3931	T6019	T6018	punct	-,D2R
R3932	T6020	T6018	punct	/,D2R
R3933	T6021	T6018	punct	-,D2R
R3934	T6022	T5996	punct	", ",prevents
R3935	T6023	T6024	advmod	thus,impairing
R3936	T6024	T5996	advcl	impairing,prevents
R3937	T6025	T6026	poss	their,ability
R3938	T6026	T6024	dobj	ability,impairing
R3939	T6027	T6028	aux	to,form
R3940	T6028	T6026	acl	form,ability
R3941	T6029	T6030	nmod	S,contingencies
R3942	T6030	T6028	dobj	contingencies,form
R3943	T6031	T6029	punct	+,S
R3944	T6032	T6029	punct	/,S
R3945	T6033	T6029	appos	S,S
R3946	T6034	T6033	punct	-,S
R3947	T6035	T6028	cc	and,form
R3948	T6036	T6028	conj	disengage,form
R3949	T6037	T6038	amod	inappropriate,responding
R3950	T6038	T6036	dobj	responding,disengage
R3951	T6039	T6040	compound	dopamine,D1R
R3952	T6040	T6041	npadvmod	D1R,mediated
R3953	T6041	T6038	amod	mediated,responding
R3954	T6042	T6041	punct	-,mediated
R3955	T6043	T6038	amod	associative,responding
R3956	T6044	T6045	advmod	when,happened
R3957	T6045	T6036	advcl	happened,disengage
R3958	T6046	T6047	amod	unexpected,consequences
R3959	T6047	T6045	nsubj	consequences,happened
R3960	T6048	T6047	prep	to,consequences
R3961	T6049	T6050	npadvmod	goal,directed
R3962	T6050	T6052	amod	directed,behaviors
R3963	T6051	T6050	punct	-,directed
R3964	T6052	T6048	pobj	behaviors,to
R3965	T6053	T5996	punct	.,prevents
R3966	T6055	T6056	advmod	Consequently,compelled
R3967	T6057	T6056	punct	", ",compelled
R3968	T6058	T6056	nsubjpass	we,compelled
R3969	T6059	T6056	auxpass	are,compelled
R3970	T6060	T6061	aux	to,conclude
R3971	T6061	T6056	xcomp	conclude,compelled
R3972	T6062	T6063	mark	that,reveal
R3973	T6063	T6061	ccomp	reveal,conclude
R3974	T6064	T6065	det	the,deficits
R3975	T6065	T6063	nsubj	deficits,reveal
R3976	T6066	T6065	amod	perseverative,deficits
R3977	T6067	T6065	compound	performance,deficits
R3978	T6068	T6065	acl	demonstrated,deficits
R3979	T6069	T6068	agent	by,demonstrated
R3980	T6070	T6071	det	the,mice
R3981	T6071	T6069	pobj	mice,by
R3982	T6072	T6071	nmod	D2R,mice
R3983	T6073	T6072	punct	-,D2R
R3984	T6074	T6072	punct	/,D2R
R3985	T6075	T6072	punct	-,D2R
R3986	T6076	T6068	prep	in,demonstrated
R3987	T6077	T6078	det	the,tasks
R3988	T6078	T6076	pobj	tasks,in
R3989	T6079	T6078	acl	used,tasks
R3990	T6080	T6079	prep	in,used
R3991	T6081	T6082	det	the,study
R3992	T6082	T6080	pobj	study,in
R3993	T6083	T6082	amod	present,study
R3994	T6084	T6085	det	a,role
R3995	T6085	T6063	dobj	role,reveal
R3996	T6086	T6087	advmod	previously,unreported
R3997	T6087	T6085	amod	unreported,role
R3998	T6088	T6085	prep	for,role
R3999	T6089	T6088	pobj	D2Rs,for
R40	T270	T271	amod	diverse,stimuli
R4000	T6090	T6085	prep	in,role
R4001	T6091	T6092	amod	associative,learning
R4002	T6092	T6090	pobj	learning,in
R4003	T6093	T6091	cc	and,associative
R4004	T6094	T6091	conj	reversal,associative
R4005	T6095	T6056	punct	.,compelled
R4006	T6115	T6116	det	The,mice
R4007	T6116	T6129	nsubj	mice,were
R4008	T6117	T6116	nummod	sixteen,mice
R4009	T6118	T6116	punct	", ",mice
R4010	T6119	T6120	compound	8,10
R4011	T6120	T6122	nummod	10,week
R4012	T6121	T6120	punct	–,10
R4013	T6122	T6123	npadvmod	week,old
R4014	T6123	T6116	amod	old,mice
R4015	T6124	T6116	punct	", ",mice
R4016	T6125	T6126	compound	25,30
R4017	T6126	T6128	nummod	30,g
R4018	T6127	T6126	punct	–,30
R4019	T6128	T6116	compound	g,mice
R4020	T6130	T6131	punct	(,8
R4021	T6131	T6116	parataxis	8,mice
R4022	T6132	T6131	prep	per,8
R4023	T6133	T6132	pobj	genotype,per
R4024	T6134	T6131	punct	),8
R4025	T6135	T6116	acl	used,mice
R4026	T6136	T6135	prep	in,used
R4027	T6137	T6138	det	this,study
R4028	T6138	T6136	pobj	study,in
R4029	T6139	T6140	det	the,offspring
R4030	T6140	T6129	attr	offspring,were
R4031	T6141	T6140	amod	congenic,offspring
R4032	T6142	T6140	prep	of,offspring
R4033	T6143	T6142	pobj	breeders,of
R4034	T6144	T6145	dep	that,were
R4035	T6145	T6143	relcl	were,breeders
R4036	T6146	T6145	attr	descendants,were
R4037	T6147	T6146	prep	of,descendants
R4038	T6148	T6149	det	the,hybrid
R4039	T6149	T6147	pobj	hybrid,of
R4040	T6150	T6149	amod	original,hybrid
R4041	T6151	T6149	compound	F2,hybrid
R4042	T6152	T6153	punct	(,Sv
R4043	T6153	T6149	parataxis	Sv,hybrid
R4044	T6154	T6153	nummod	129,Sv
R4045	T6155	T6153	punct	/,Sv
R4046	T6156	T6157	punct	×,6J
R4047	T6157	T6153	prep	6J,Sv
R4048	T6158	T6157	compound	C57BL,6J
R4049	T6159	T6157	punct	/,6J
R405	T1116	T1117	npadvmod	Reinforcement,mediated
R4050	T6160	T6161	punct	;,Kelly
R4051	T6161	T6149	meta	Kelly,hybrid
R4052	T6162	T6161	nmod	et,Kelly
R4053	T6163	T6161	nmod	al.,Kelly
R4054	T6164	T6161	punct	", ",Kelly
R4055	T6165	T6161	nummod	1997,Kelly
R4056	T6166	T6161	punct	),Kelly
R4057	T6167	T6168	dep	that,backcrossed
R4058	T6168	T6149	relcl	backcrossed,hybrid
R4059	T6169	T6168	auxpass	was,backcrossed
R406	T1117	T1119	amod	mediated,learning
R4060	T6170	T6168	prep	to,backcrossed
R4061	T6171	T6172	amod	inbred,stock
R4062	T6172	T6170	pobj	stock,to
R4063	T6173	T6174	compound	C57Bl,6J
R4064	T6174	T6172	compound	6J,stock
R4065	T6175	T6174	punct	/,6J
R4066	T6176	T6177	punct	(,Laboratories
R4067	T6177	T6168	parataxis	Laboratories,backcrossed
R4068	T6178	T6177	compound	Jackson,Laboratories
R4069	T6179	T6177	punct	", ",Laboratories
R407	T1118	T1117	punct	-,mediated
R4070	T6180	T6177	npadvmod	ME,Laboratories
R4071	T6181	T6177	punct	),Laboratories
R4072	T6182	T6129	punct	.,were
R4073	T6184	T6185	det	This,strategy
R4074	T6185	T6187	nsubjpass	strategy,repeated
R4075	T6186	T6185	compound	breeding,strategy
R4076	T6188	T6187	auxpass	was,repeated
R4077	T6189	T6187	prep	for,repeated
R4078	T6190	T6191	nummod	20,generations
R4079	T6191	T6189	pobj	generations,for
R408	T1119	T1121	nsubjpass	learning,divided
R4080	T6192	T6191	amod	successive,generations
R4081	T6193	T6187	prep	with,repeated
R4082	T6194	T6195	det	the,gender
R4083	T6195	T6193	pobj	gender,with
R4084	T6196	T6195	prep	of,gender
R4085	T6197	T6198	det	the,mutant
R4086	T6198	T6196	pobj	mutant,of
R4087	T6199	T6198	compound	donor,mutant
R4088	T6200	T6198	punct	/,mutant
R4089	T6201	T6195	acl	alternating,gender
R409	T1120	T1119	amod	associative,learning
R4090	T6202	T6201	prep	with,alternating
R4091	T6203	T6204	det	each,generation
R4092	T6204	T6202	pobj	generation,with
R4093	T6205	T6187	punct	.,repeated
R4094	T6207	T6208	det	All,subjects
R4095	T6208	T6210	nsubjpass	subjects,genotyped
R4096	T6209	T6208	amod	experimental,subjects
R4097	T6211	T6210	auxpass	were,genotyped
R4098	T6212	T6210	prep	by,genotyped
R4099	T6213	T6212	pobj	PCR,by
R41	T271	T269	dobj	stimuli,integrating
R410	T1122	T1119	punct	", ",learning
R4100	T6214	T6215	mark	as,described
R4101	T6215	T6210	advcl	described,genotyped
R4102	T6216	T6215	advmod	previously,described
R4103	T6217	T6218	punct	[,23
R4104	T6218	T6215	parataxis	23,described
R4105	T6219	T6218	punct	],23
R4106	T6220	T6210	punct	.,genotyped
R4107	T6222	T6223	det	All,testing
R4108	T6223	T6224	nsubj	testing,occured
R4109	T6225	T6224	advmod	randomly,occured
R411	T1123	T1119	cc	or,learning
R4110	T6226	T6224	prep	across,occured
R4111	T6227	T6228	amod	estrous,cycles
R4112	T6228	T6226	pobj	cycles,across
R4113	T6229	T6224	punct	.,occured
R4114	T6231	T6232	det	The,Department
R4115	T6232	T6233	nsubj	Department,approved
R4116	T6234	T6232	prep	of,Department
R4117	T6235	T6236	compound	Comparative,Medicine
R4118	T6236	T6234	pobj	Medicine,of
R4119	T6237	T6232	prep	at,Department
R412	T1124	T1125	det	the,ability
R4120	T6238	T6239	nmod	Oregon,University
R4121	T6239	T6237	pobj	University,at
R4122	T6240	T6239	nmod	Health,University
R4123	T6241	T6240	cc	and,Health
R4124	T6242	T6240	conj	Science,Health
R4125	T6243	T6244	det	all,protocols
R4126	T6244	T6233	dobj	protocols,approved
R4127	T6245	T6233	punct	", ",approved
R4128	T6246	T6233	cc	and,approved
R4129	T6247	T6248	det	all,animals
R413	T1125	T1119	conj	ability,learning
R4130	T6248	T6249	nsubjpass	animals,maintained
R4131	T6249	T6233	conj	maintained,approved
R4132	T6250	T6249	auxpass	were,maintained
R4133	T6251	T6249	prep	in,maintained
R4134	T6252	T6251	pobj	accordance,in
R4135	T6253	T6252	prep	to,accordance
R4136	T6254	T6255	compound	National,Institutes
R4137	T6255	T6256	poss	Institutes,Guide
R4138	T6256	T6253	pobj	Guide,to
R4139	T6257	T6255	prep	of,Institutes
R414	T1126	T1127	aux	to,ascribe
R4140	T6258	T6257	pobj	Health,of
R4141	T6259	T6255	case	's,Institutes
R4142	T6260	T6256	prep	for,Guide
R4143	T6261	T6262	det	the,Care
R4144	T6262	T6260	pobj	Care,for
R4145	T6263	T6262	cc	and,Care
R4146	T6264	T6262	conj	Use,Care
R4147	T6265	T6262	prep	of,Care
R4148	T6266	T6267	compound	Laboratory,Animals
R4149	T6267	T6265	pobj	Animals,of
R415	T1127	T1125	acl	ascribe,ability
R4150	T6268	T6249	punct	.,maintained
R4151	T6404	T6405	amod	Experimental,procedures
R4152	T6407	T6408	compound	Odor,training
R4153	T6409	T6408	compound	discrimination,training
R4154	T6410	T6408	cc	and,training
R4155	T6411	T6408	conj	testing,training
R4156	T6413	T6414	det	A,paradigm
R4157	T6414	T6419	nsubjpass	paradigm,chosen
R4158	T6415	T6416	nummod	2,odor
R4159	T6416	T6414	compound	odor,paradigm
R416	T1128	T1129	amod	deterministic,relationships
R4160	T6417	T6416	punct	-,odor
R4161	T6418	T6414	compound	discrimination,paradigm
R4162	T6420	T6419	auxpass	was,chosen
R4163	T6421	T6422	mark	because,permits
R4164	T6422	T6419	advcl	permits,chosen
R4165	T6423	T6422	nsubj	it,permits
R4166	T6424	T6425	det	a,measure
R4167	T6425	T6422	dobj	measure,permits
R4168	T6426	T6425	prep	of,measure
R4169	T6427	T6428	amod	attentional,focus
R417	T1129	T1127	dobj	relationships,ascribe
R4170	T6428	T6426	pobj	focus,of
R4171	T6429	T6425	prep	in,measure
R4172	T6430	T6431	npadvmod	goal,directed
R4173	T6431	T6433	amod	directed,behavior
R4174	T6432	T6431	punct	-,directed
R4175	T6433	T6429	pobj	behavior,in
R4176	T6434	T6419	punct	.,chosen
R4177	T6436	T6437	compound	Odor,discrimination
R4178	T6437	T6438	nsubjpass	discrimination,chosen
R4179	T6439	T6438	auxpass	was,chosen
R418	T1130	T1129	prep	between,relationships
R4180	T6440	T6438	prep	as,chosen
R4181	T6441	T6442	det	the,task
R4182	T6442	T6440	pobj	task,as
R4183	T6443	T6442	amod	particular,task
R4184	T6444	T6445	mark	because,is
R4185	T6445	T6438	advcl	is,chosen
R4186	T6446	T6445	nsubj	it,is
R4187	T6447	T6448	det	a,behavior
R4188	T6448	T6445	attr	behavior,is
R4189	T6449	T6450	advmod	highly,robust
R419	T1131	T1132	amod	environmental,stimuli
R4190	T6450	T6448	amod	robust,behavior
R4191	T6451	T6445	prep	in,is
R4192	T6452	T6451	pobj	rodents,in
R4193	T6453	T6454	punct	[,18
R4194	T6454	T6445	parataxis	18,is
R4195	T6455	T6454	punct	],18
R4196	T6456	T6438	punct	.,chosen
R4197	T6458	T6459	aux	To,minimize
R4198	T6459	T6460	advcl	minimize,was
R4199	T6461	T6462	amod	experimental,error
R42	T272	T271	amod	external,stimuli
R420	T1132	T1130	pobj	stimuli,between
R4200	T6462	T6459	dobj	error,minimize
R4201	T6463	T6460	punct	", ",was
R4202	T6464	T6465	det	the,experimenter
R4203	T6465	T6460	nsubj	experimenter,was
R4204	T6466	T6460	acomp	blind,was
R4205	T6467	T6466	prep	to,blind
R4206	T6468	T6467	pobj	genotype,to
R4207	T6469	T6460	prep	during,was
R4208	T6470	T6469	pobj	testing,during
R4209	T6471	T6460	punct	.,was
R421	T1133	T1134	dep	that,signal
R4210	T6473	T6474	nsubj	Mice,were
R4211	T6475	T6476	advmod	mildly,deprived
R4212	T6476	T6474	acomp	deprived,were
R4213	T6477	T6476	npadvmod	food,deprived
R4214	T6478	T6474	prep	to,were
R4215	T6479	T6480	advmod	approximately,85
R4216	T6480	T6481	nummod	85,%
R4217	T6481	T6482	nmod	%,weight
R4218	T6482	T6478	pobj	weight,to
R4219	T6483	T6484	nmod	ad,libitum
R422	T1134	T1132	relcl	signal,stimuli
R4220	T6484	T6482	nmod	libitum,weight
R4221	T6485	T6474	punct	.,were
R4222	T6487	T6488	nmod	Dopamine,D2R
R4223	T6488	T6489	nmod	D2R,mice
R4224	T6489	T6498	nsubjpass	mice,trained
R4225	T6490	T6488	punct	-,D2R
R4226	T6491	T6488	punct	/,D2R
R4227	T6492	T6488	punct	-,D2R
R4228	T6493	T6488	cc	and,D2R
R4229	T6494	T6488	conj	D2R,D2R
R423	T1135	T1136	det	the,probability
R4230	T6495	T6494	punct	+,D2R
R4231	T6496	T6494	punct	/,D2R
R4232	T6497	T6494	punct	+,D2R
R4233	T6499	T6500	punct	(,8
R4234	T6500	T6489	parataxis	8,mice
R4235	T6501	T6500	nsubj	n,8
R4236	T6502	T6500	punct	=,8
R4237	T6503	T6500	prep	per,8
R4238	T6504	T6503	pobj	group,per
R4239	T6505	T6500	punct	),8
R424	T1136	T1134	dobj	probability,signal
R4240	T6506	T6498	auxpass	were,trained
R4241	T6507	T6498	advmod	initially,trained
R4242	T6508	T6509	aux	to,ambulate
R4243	T6509	T6498	xcomp	ambulate,trained
R4244	T6510	T6511	det	the,length
R4245	T6511	T6509	dobj	length,ambulate
R4246	T6512	T6511	prep	of,length
R4247	T6513	T6514	det	a,cage
R4248	T6514	T6512	pobj	cage,of
R4249	T6515	T6514	compound	polyvinyl,cage
R425	T1137	T1136	prep	of,probability
R4250	T6516	T6514	compound	mouse,cage
R4251	T6517	T6518	punct	(,cm
R4252	T6518	T6509	parataxis	cm,ambulate
R4253	T6519	T6518	nummod	30,cm
R4254	T6520	T6518	punct	-,cm
R4255	T6521	T6518	punct	),cm
R4256	T6522	T6523	aux	to,retrieve
R4257	T6523	T6509	dep	retrieve,ambulate
R4258	T6524	T6525	punct	~,30
R4259	T6525	T6526	nummod	30,mg
R426	T1138	T1137	pcomp	receiving,of
R4260	T6526	T6523	dobj	mg,retrieve
R4261	T6527	T6526	punct	-,mg
R4262	T6528	T6526	prep	of,mg
R4263	T6529	T6530	compound	Pico®,fat
R4264	T6530	T6531	npadvmod	fat,supplemented
R4265	T6531	T6532	amod	supplemented,food
R4266	T6532	T6528	pobj	food,of
R4267	T6533	T6532	compound	rodent,food
R4268	T6534	T6526	acl	located,mg
R4269	T6535	T6534	prep	in,located
R427	T1139	T1140	det	a,reinforcer
R4270	T6536	T6537	det	a,cup
R4271	T6537	T6535	pobj	cup,in
R4272	T6538	T6537	amod	small,cup
R4273	T6539	T6537	compound	plastic,cup
R4274	T6540	T6541	punct	(,cm
R4275	T6541	T6537	parataxis	cm,cup
R4276	T6542	T6541	nummod	3,cm
R4277	T6543	T6541	punct	-,cm
R4278	T6544	T6541	punct	),cm
R4279	T6545	T6537	acl	attached,cup
R428	T1140	T1138	dobj	reinforcer,receiving
R4280	T6546	T6545	prep	to,attached
R4281	T6547	T6548	det	the,floor
R4282	T6548	T6546	pobj	floor,to
R4283	T6549	T6548	prep	of,floor
R4284	T6550	T6551	det	the,apparatus
R4285	T6551	T6549	pobj	apparatus,of
R4286	T6552	T6551	compound	testing,apparatus
R4287	T6553	T6545	prep	with,attached
R4288	T6554	T6553	pobj	Velcro,with
R4289	T6555	T6498	punct	.,trained
R429	T1141	T1140	amod	primary,reinforcer
R4290	T6557	T6558	det	Each,subject
R4291	T6558	T6559	nsubj	subject,received
R4292	T6560	T6561	nummod	five,trials
R4293	T6561	T6559	dobj	trials,received
R4294	T6562	T6559	punct	", ",received
R4295	T6563	T6559	cc	and,received
R4296	T6564	T6565	det	the,latency
R4297	T6565	T6566	nsubjpass	latency,recorded
R4298	T6566	T6559	conj	recorded,received
R4299	T6567	T6568	aux	to,locate
R43	T273	T271	amod	sensory,stimuli
R430	T1142	T1140	punct	(,reinforcer
R4300	T6568	T6565	advcl	locate,latency
R4301	T6569	T6568	cc	and,locate
R4302	T6570	T6568	conj	start,locate
R4303	T6571	T6572	aux	to,consume
R4304	T6572	T6570	xcomp	consume,start
R4305	T6573	T6574	det	the,pellet
R4306	T6574	T6570	dobj	pellet,start
R4307	T6575	T6574	compound	food,pellet
R4308	T6576	T6566	auxpass	was,recorded
R4309	T6577	T6566	advmod	manually,recorded
R431	T1143	T1144	advmod	e.g.,food
R4310	T6578	T6566	prep	with,recorded
R4311	T6579	T6580	det	a,stopwatch
R4312	T6580	T6578	pobj	stopwatch,with
R4313	T6581	T6580	amod	standard,stopwatch
R4314	T6582	T6583	amod	hand,held
R4315	T6583	T6580	amod	held,stopwatch
R4316	T6584	T6583	punct	-,held
R4317	T6585	T6566	punct	.,recorded
R4318	T6587	T6588	compound	Twenty,four
R4319	T6588	T6590	nummod	four,hours
R432	T1144	T1140	appos	food,reinforcer
R4320	T6589	T6588	punct	-,four
R4321	T6590	T6591	npadvmod	hours,later
R4322	T6591	T6592	advmod	later,trained
R4323	T6593	T6592	nsubjpass	subjects,trained
R4324	T6594	T6592	auxpass	were,trained
R4325	T6595	T6596	aux	to,ambulate
R4326	T6596	T6592	xcomp	ambulate,trained
R4327	T6597	T6596	prep	towards,ambulate
R4328	T6598	T6596	cc	and,ambulate
R4329	T6599	T6596	conj	dig,ambulate
R433	T1145	T1140	punct	),reinforcer
R4330	T6600	T6599	prep	through,dig
R4331	T6601	T6602	det	the,dish
R4332	T6602	T6599	dobj	dish,dig
R4333	T6603	T6602	amod	same,dish
R4334	T6604	T6605	nummod	3,cm
R4335	T6605	T6602	compound	cm,dish
R4336	T6606	T6605	punct	-,cm
R4337	T6607	T6602	acl	filled,dish
R4338	T6608	T6607	prep	with,filled
R4339	T6609	T6610	amod	sterile,sand
R434	T1146	T1121	punct	", ",divided
R4340	T6610	T6608	pobj	sand,with
R4341	T6611	T6612	aux	to,locate
R4342	T6612	T6596	advcl	locate,ambulate
R4343	T6613	T6614	det	a,pellet
R4344	T6614	T6612	dobj	pellet,locate
R4345	T6615	T6614	compound	food,pellet
R4346	T6616	T6614	acl	buried,pellet
R4347	T6617	T6616	prep	underneath,buried
R4348	T6618	T6619	det	the,sand
R4349	T6619	T6617	pobj	sand,underneath
R435	T1147	T1121	aux	has,divided
R4350	T6620	T6592	punct	.,trained
R4351	T6622	T6623	nsubj	Subjects,received
R4352	T6624	T6625	nummod	10,trials
R4353	T6625	T6623	dobj	trials,received
R4354	T6626	T6623	punct	.,received
R4355	T6628	T6629	mark	If,failed
R4356	T6629	T6632	advcl	failed,dropped
R4357	T6630	T6631	det	a,mouse
R4358	T6631	T6629	nsubj	mouse,failed
R4359	T6633	T6634	aux	to,locate
R436	T1148	T1121	auxpass	been,divided
R4360	T6634	T6629	xcomp	locate,failed
R4361	T6635	T6636	det	a,pellet
R4362	T6636	T6634	dobj	pellet,locate
R4363	T6637	T6636	compound	food,pellet
R4364	T6638	T6634	prep	within,locate
R4365	T6639	T6640	nummod	10,min
R4366	T6640	T6638	pobj	min,within
R4367	T6641	T6640	punct	-,min
R4368	T6642	T6640	prep	of,min
R4369	T6643	T6644	det	the,trial
R437	T1149	T1121	prep	into,divided
R4370	T6644	T6642	pobj	trial,of
R4371	T6645	T6644	amod	first,trial
R4372	T6646	T6632	punct	", ",dropped
R4373	T6647	T6648	det	an,pellet
R4374	T6648	T6632	nsubjpass	pellet,dropped
R4375	T6649	T6648	amod	additional,pellet
R4376	T6650	T6648	compound	food,pellet
R4377	T6651	T6632	auxpass	was,dropped
R4378	T6652	T6632	prep	on,dropped
R4379	T6653	T6652	pobj	top,on
R438	T1150	T1151	nummod	3,components
R4380	T6654	T6653	prep	of,top
R4381	T6655	T6656	det	the,dish
R4382	T6656	T6654	pobj	dish,of
R4383	T6657	T6632	punct	.,dropped
R4384	T6659	T6660	det	This,manipulation
R4385	T6660	T6661	nsubj	manipulation,ensured
R4386	T6662	T6661	advmod	usually,ensured
R4387	T6663	T6664	mark	that,dig
R4388	T6664	T6661	ccomp	dig,ensured
R4389	T6665	T6666	det	a,subject
R439	T1151	T1149	pobj	components,into
R4390	T6666	T6664	nsubj	subject,dig
R4391	T6667	T6664	aux	would,dig
R4392	T6668	T6664	prep	through,dig
R4393	T6669	T6670	det	the,sand
R4394	T6670	T6668	pobj	sand,through
R4395	T6671	T6672	aux	to,locate
R4396	T6672	T6664	advcl	locate,dig
R4397	T6673	T6674	det	the,pellet
R4398	T6674	T6672	dobj	pellet,locate
R4399	T6675	T6674	amod	original,pellet
R44	T274	T267	cc	and,processing
R440	T1152	T1151	cc	or,components
R4400	T6676	T6672	cc	and,locate
R4401	T6677	T6672	conj	learn,locate
R4402	T6678	T6679	det	this,task
R4403	T6679	T6677	dobj	task,learn
R4404	T6680	T6661	punct	.,ensured
R4405	T6682	T6683	det	The,day
R4406	T6683	T6685	npadvmod	day,presented
R4407	T6684	T6683	amod	next,day
R4408	T6686	T6685	punct	", ",presented
R4409	T6687	T6685	nsubjpass	mice,presented
R441	T1153	T1151	conj	stages,components
R4410	T6688	T6685	auxpass	were,presented
R4411	T6689	T6685	prep	to,presented
R4412	T6690	T6691	det	the,apparatus
R4413	T6691	T6689	pobj	apparatus,to
R4414	T6692	T6691	compound	testing,apparatus
R4415	T6693	T6694	dep	that,contained
R4416	T6694	T6691	relcl	contained,apparatus
R4417	T6695	T6694	advmod	now,contained
R4418	T6696	T6697	nummod	2,dishes
R4419	T6697	T6694	dobj	dishes,contained
R442	T1154	T1155	punct	[,1
R4420	T6698	T6697	punct	", ",dishes
R4421	T6699	T6697	appos	each,dishes
R4422	T6700	T6699	acl	filled,each
R4423	T6701	T6700	prep	with,filled
R4424	T6702	T6703	amod	different,scented
R4425	T6703	T6704	amod	scented,sand
R4426	T6704	T6701	pobj	sand,with
R4427	T6705	T6685	punct	.,presented
R4428	T6707	T6708	nummod	One,odor
R4429	T6708	T6709	nsubj	odor,signaled
R443	T1155	T1121	parataxis	1,divided
R4430	T6710	T6711	mark	that,buried
R4431	T6711	T6709	ccomp	buried,signaled
R4432	T6712	T6713	det	a,reinforcer
R4433	T6713	T6711	nsubjpass	reinforcer,buried
R4434	T6714	T6713	compound	food,reinforcer
R4435	T6715	T6711	auxpass	was,buried
R4436	T6716	T6711	prep	in,buried
R4437	T6717	T6718	det	that,dish
R4438	T6718	T6716	pobj	dish,in
R4439	T6719	T6718	amod	particular,dish
R444	T1156	T1155	punct	],1
R4440	T6720	T6721	punct	(,S
R4441	T6721	T6711	parataxis	S,buried
R4442	T6722	T6721	punct	+,S
R4443	T6723	T6721	punct	),S
R4444	T6724	T6725	mark	while,signaled
R4445	T6725	T6711	advcl	signaled,buried
R4446	T6726	T6727	det	the,odor
R4447	T6727	T6725	nsubj	odor,signaled
R4448	T6728	T6727	amod	other,odor
R4449	T6729	T6730	mark	that,contained
R445	T1157	T1121	punct	.,divided
R4450	T6730	T6725	ccomp	contained,signaled
R4451	T6731	T6732	det	no,reinforcer
R4452	T6732	T6730	nsubjpass	reinforcer,contained
R4453	T6733	T6730	auxpass	was,contained
R4454	T6734	T6730	prep	within,contained
R4455	T6735	T6736	det	that,dish
R4456	T6736	T6734	pobj	dish,within
R4457	T6737	T6736	amod	particular,dish
R4458	T6738	T6739	punct	(,S
R4459	T6739	T6730	parataxis	S,contained
R446	T1159	T1160	det	The,stage
R4460	T6740	T6739	punct	-,S
R4461	T6741	T6739	punct	),S
R4462	T6742	T6709	punct	.,signaled
R4463	T6744	T6745	det	The,sand
R4464	T6745	T6746	nsubjpass	sand,scented
R4465	T6747	T6746	auxpass	was,scented
R4466	T6748	T6746	prep	by,scented
R4467	T6749	T6748	pcomp	adding,by
R4468	T6750	T6751	nummod	0.80,grams
R4469	T6751	T6749	dobj	grams,adding
R447	T1160	T1164	nsubj	stage,is
R4470	T6752	T6751	prep	of,grams
R4471	T6753	T6754	preconj	either,cinnamon
R4472	T6754	T6752	pobj	cinnamon,of
R4473	T6755	T6754	cc	or,cinnamon
R4474	T6756	T6757	compound	dill,weed
R4475	T6757	T6754	conj	weed,cinnamon
R4476	T6758	T6749	prep	to,adding
R4477	T6759	T6760	nummod	98.8,grams
R4478	T6760	T6758	pobj	grams,to
R4479	T6761	T6760	prep	of,grams
R448	T1161	T1160	amod	first,stage
R4480	T6762	T6763	amod	autoclaved,sand
R4481	T6763	T6761	pobj	sand,of
R4482	T6764	T6763	compound	playground,sand
R4483	T6765	T6763	acl	purchased,sand
R4484	T6766	T6765	prep	from,purchased
R4485	T6767	T6768	det	a,store
R4486	T6768	T6766	pobj	store,from
R4487	T6769	T6768	amod	local,store
R4488	T6770	T6768	nmod	farm,store
R4489	T6771	T6770	cc	and,farm
R449	T1162	T1160	punct	", ",stage
R4490	T6772	T6770	conj	garden,farm
R4491	T6773	T6746	punct	.,scented
R4492	T6775	T6776	advmod	Finally,mixed
R4493	T6777	T6776	punct	", ",mixed
R4494	T6778	T6779	nummod	0.40,grams
R4495	T6779	T6776	nsubjpass	grams,mixed
R4496	T6780	T6779	prep	of,grams
R4497	T6781	T6782	advmod	finely,ground
R4498	T6782	T6783	amod	ground,food
R4499	T6783	T6780	pobj	food,of
R45	T275	T267	conj	attaching,processing
R450	T1163	T1160	amod	unlearned,stage
R4500	T6784	T6776	auxpass	was,mixed
R4501	T6785	T6776	prep	with,mixed
R4502	T6786	T6787	det	the,sand
R4503	T6787	T6785	pobj	sand,with
R4504	T6788	T6787	amod	scented,sand
R4505	T6789	T6776	prep	in,mixed
R4506	T6790	T6789	pobj	order,in
R4507	T6791	T6792	aux	to,mask
R4508	T6792	T6790	acl	mask,order
R4509	T6793	T6794	det	any,odor
R451	T1165	T1166	det	the,organism
R4510	T6794	T6792	dobj	odor,mask
R4511	T6795	T6794	acl	emitted,odor
R4512	T6796	T6795	agent	by,emitted
R4513	T6797	T6798	det	the,reinforcer
R4514	T6798	T6796	pobj	reinforcer,by
R4515	T6799	T6798	compound	food,reinforcer
R4516	T6800	T6798	prep	in,reinforcer
R4517	T6801	T6802	det	the,dish
R4518	T6802	T6800	pobj	dish,in
R4519	T6803	T6802	nmod	S,dish
R452	T1166	T1167	poss	organism,experience
R4520	T6804	T6803	punct	+,S
R4521	T6805	T6776	punct	.,mixed
R4522	T6807	T6808	det	This,mixture
R4523	T6808	T6810	nsubj	mixture,appear
R4524	T6809	T6808	amod	final,mixture
R4525	T6811	T6810	aux	did,appear
R4526	T6812	T6810	neg	not,appear
R4527	T6813	T6814	aux	to,be
R4528	T6814	T6810	xcomp	be,appear
R4529	T6815	T6814	acomp	palatable,be
R453	T1167	T1164	attr	experience,is
R4530	T6816	T6814	prep	to,be
R4531	T6817	T6818	det	the,subjects
R4532	T6818	T6816	pobj	subjects,to
R4533	T6819	T6810	punct	.,appear
R4534	T6821	T6822	det	A,trial
R4535	T6822	T6823	nsubj	trial,terminated
R4536	T6824	T6825	advmod	when,dug
R4537	T6825	T6823	advcl	dug,terminated
R4538	T6826	T6827	det	the,mouse
R4539	T6827	T6825	nsubj	mouse,dug
R454	T1168	T1166	case	's,organism
R4540	T6828	T6825	punct	: ,dug
R4541	T6829	T6825	prep	in,dug
R4542	T6830	T6831	det	the,dish
R4543	T6831	T6829	pobj	dish,in
R4544	T6832	T6831	amod	correct,dish
R4545	T6833	T6825	cc	and,dug
R4546	T6834	T6825	conj	consumed,dug
R4547	T6835	T6836	det	the,pellet
R4548	T6836	T6834	dobj	pellet,consumed
R4549	T6837	T6836	amod	hidden,pellet
R455	T1169	T1167	prep	with,experience
R4550	T6838	T6825	punct	", ",dug
R4551	T6839	T6825	cc	or,dug
R4552	T6840	T6825	conj	began,dug
R4553	T6841	T6842	aux	to,dig
R4554	T6842	T6840	xcomp	dig,began
R4555	T6843	T6842	prep	in,dig
R4556	T6844	T6845	det	the,dish
R4557	T6845	T6843	pobj	dish,in
R4558	T6846	T6845	amod	incorrect,dish
R4559	T6847	T6823	punct	.,terminated
R456	T1170	T1171	det	a,reinforcer
R4560	T6849	T6850	nsubjpass	Digging,considered
R4561	T6851	T6850	auxpass	was,considered
R4562	T6852	T6853	det	the,displacement
R4563	T6853	T6850	oprd	displacement,considered
R4564	T6854	T6853	amod	actual,displacement
R4565	T6855	T6853	amod	physical,displacement
R4566	T6856	T6853	prep	of,displacement
R4567	T6857	T6856	pobj	sand,of
R4568	T6858	T6853	prep	with,displacement
R4569	T6859	T6860	det	the,forepaws
R457	T1171	T1169	pobj	reinforcer,with
R4570	T6860	T6858	pobj	forepaws,with
R4571	T6861	T6860	cc	and,forepaws
R4572	T6862	T6861	punct	/,and
R4573	T6863	T6861	cc	or,and
R4574	T6864	T6860	conj	snout,forepaws
R4575	T6865	T6850	punct	.,considered
R4576	T6867	T6868	csubjpass	Placing,considered
R4577	T6869	T6867	dobj	forelimbs,Placing
R4578	T6870	T6867	prep	on,Placing
R4579	T6871	T6870	pobj	either,on
R458	T1172	T1171	amod	primary,reinforcer
R4580	T6872	T6871	prep	of,either
R4581	T6873	T6874	det	the,dishes
R4582	T6874	T6872	pobj	dishes,of
R4583	T6875	T6867	cc	and,Placing
R4584	T6876	T6867	conj	sniffing,Placing
R4585	T6877	T6868	auxpass	was,considered
R4586	T6878	T6868	neg	not,considered
R4587	T6879	T6868	oprd	digging,considered
R4588	T6880	T6868	cc	and,considered
R4589	T6881	T6882	auxpass	was,penalized
R459	T1173	T1174	dep	that,elicits
R4590	T6882	T6868	conj	penalized,considered
R4591	T6883	T6882	neg	not,penalized
R4592	T6884	T6882	cc	or,penalized
R4593	T6885	T6882	conj	scored,penalized
R4594	T6886	T6868	punct	.,considered
R4595	T6888	T6889	det	Each,trial
R4596	T6889	T6891	nsubjpass	trial,separated
R4597	T6890	T6889	amod	completed,trial
R4598	T6892	T6891	auxpass	was,separated
R4599	T6893	T6891	prep	by,separated
R46	T276	T275	dobj	salience,attaching
R460	T1174	T1171	relcl	elicits,reinforcer
R4600	T6894	T6895	det	a,sec
R4601	T6895	T6893	pobj	sec,by
R4602	T6896	T6895	nummod	20,sec
R4603	T6897	T6895	punct	-,sec
R4604	T6898	T6899	compound	inter-trial,interval
R4605	T6899	T6895	appos	interval,sec
R4606	T6900	T6899	punct	-,interval
R4607	T6901	T6899	punct	(,interval
R4608	T6902	T6899	appos	ITI,interval
R4609	T6903	T6891	punct	),separated
R461	T1175	T1176	det	some,response
R4610	T6904	T6891	punct	.,separated
R4611	T6906	T6907	amod	Preliminary,experiments
R4612	T6907	T6908	nsubj	experiments,demonstrated
R4613	T6909	T6910	mark	that,required
R4614	T6910	T6908	ccomp	required,demonstrated
R4615	T6911	T6912	det	an,period
R4616	T6912	T6910	nsubjpass	period,required
R4617	T6913	T6912	amod	extended,period
R4618	T6914	T6912	nmod	time,period
R4619	T6915	T6914	punct	-,time
R462	T1176	T1174	dobj	response,elicits
R4620	T6916	T6914	prt	out,time
R4621	T6917	T6912	prep	following,period
R4622	T6918	T6919	det	an,response
R4623	T6919	T6917	pobj	response,following
R4624	T6920	T6919	amod	incorrect,response
R4625	T6921	T6910	auxpass	was,required
R4626	T6922	T6910	neg	not,required
R4627	T6923	T6924	aux	to,ensure
R4628	T6924	T6910	xcomp	ensure,required
R4629	T6925	T6926	npadvmod	goal,directed
R463	T1177	T1178	amod	unlearned,innate
R4630	T6926	T6928	amod	directed,behavior
R4631	T6927	T6926	punct	-,directed
R4632	T6928	T6924	dobj	behavior,ensure
R4633	T6929	T6924	prep	in,ensure
R4634	T6930	T6931	det	the,mice
R4635	T6931	T6929	pobj	mice,in
R4636	T6932	T6933	amod	wild,type
R4637	T6933	T6931	nmod	type,mice
R4638	T6934	T6933	punct	-,type
R4639	T6935	T6933	cc	or,type
R464	T1178	T1176	amod	innate,response
R4640	T6936	T6933	conj	mutant,type
R4641	T6937	T6924	prep	for,ensure
R4642	T6938	T6939	det	this,task
R4643	T6939	T6937	pobj	task,for
R4644	T6940	T6939	amod	particular,task
R4645	T6941	T6942	punct	(,shown
R4646	T6942	T6908	parataxis	shown,demonstrated
R4647	T6943	T6942	nsubj	data,shown
R4648	T6944	T6942	neg	not,shown
R4649	T6945	T6942	punct	),shown
R465	T1179	T1178	punct	/,innate
R4650	T6946	T6908	punct	.,demonstrated
R4651	T6948	T6949	advmod	Therefore,used
R4652	T6950	T6949	punct	", ",used
R4653	T6951	T6952	det	the,ITI
R4654	T6952	T6949	nsubjpass	ITI,used
R4655	T6953	T6954	nummod	20,sec
R4656	T6954	T6952	compound	sec,ITI
R4657	T6955	T6954	punct	-,sec
R4658	T6956	T6949	auxpass	was,used
R4659	T6957	T6958	aux	to,separate
R466	T1180	T1176	amod	physiological,response
R4660	T6958	T6949	advcl	separate,used
R4661	T6959	T6960	det	all,trials
R4662	T6960	T6958	dobj	trials,separate
R4663	T6961	T6960	punct	(,trials
R4664	T6962	T6960	amod	successful,trials
R4665	T6963	T6962	cc	and,successful
R4666	T6964	T6962	conj	unsuccessful,successful
R4667	T6965	T6960	punct	),trials
R4668	T6966	T6949	punct	.,used
R4669	T6968	T6969	det	The,scents
R467	T1181	T1176	punct	(,response
R4670	T6969	T6975	nsubjpass	scents,counterbalanced
R4671	T6970	T6969	nmod	S,scents
R4672	T6971	T6970	punct	+,S
R4673	T6972	T6970	cc	and,S
R4674	T6973	T6970	conj	S,S
R4675	T6974	T6973	punct	-,S
R4676	T6976	T6975	auxpass	were,counterbalanced
R4677	T6977	T6975	prep	across,counterbalanced
R4678	T6978	T6977	pobj	subjects,across
R4679	T6979	T6975	prep	in,counterbalanced
R468	T1182	T1183	advmod	e.g.,palatability
R4680	T6980	T6979	pobj	order,in
R4681	T6981	T6982	aux	to,control
R4682	T6982	T6980	acl	control,order
R4683	T6983	T6982	prep	for,control
R4684	T6984	T6985	amod	potential,bias
R4685	T6985	T6983	pobj	bias,for
R4686	T6986	T6985	amod	scent,bias
R4687	T6987	T6988	punct	(,shown
R4688	T6988	T6975	parataxis	shown,counterbalanced
R4689	T6989	T6990	compound	pilot,data
R469	T1183	T1176	appos	palatability,response
R4690	T6990	T6991	nsubj	data,suggest
R4691	T6991	T6988	ccomp	suggest,shown
R4692	T6992	T6993	expl	there,are
R4693	T6993	T6991	advcl	are,suggest
R4694	T6994	T6995	det	no,biases
R4695	T6995	T6993	attr	biases,are
R4696	T6996	T6988	punct	", ",shown
R4697	T6997	T6988	nsubj	data,shown
R4698	T6998	T6988	neg	not,shown
R4699	T6999	T6988	punct	),shown
R47	T277	T275	prep	to,attaching
R470	T1184	T1183	prep	of,palatability
R4700	T7000	T6975	punct	.,counterbalanced
R4701	T7002	T7003	prep	Following,began
R4702	T7004	T7005	amod	accurate,discrimination
R4703	T7005	T7002	pobj	discrimination,Following
R4704	T7006	T7005	punct	", ",discrimination
R4705	T7007	T7005	acl	defined,discrimination
R4706	T7008	T7007	prep	as,defined
R4707	T7009	T7010	nummod	8,retrievals
R4708	T7010	T7008	pobj	retrievals,as
R4709	T7011	T7010	amod	correct,retrievals
R471	T1185	T1186	det	a,food
R4710	T7012	T7010	prep	across,retrievals
R4711	T7013	T7014	nummod	10,trials
R4712	T7014	T7012	pobj	trials,across
R4713	T7015	T7014	amod	consecutive,trials
R4714	T7016	T7003	punct	", ",began
R4715	T7017	T7018	compound	reversal,trials
R4716	T7018	T7003	nsubj	trials,began
R4717	T7019	T7003	punct	.,began
R4718	T7021	T7022	compound	Reversal,learning
R4719	T7022	T7023	compound	learning,measurement
R472	T1186	T1184	pobj	food,of
R4720	T7025	T7026	nsubj	We,investigated
R4721	T7026	T7028	ccomp	investigated,signaled
R4722	T7027	T7026	advmod	next,investigated
R4723	T7029	T7030	det	the,contribution
R4724	T7030	T7026	dobj	contribution,investigated
R4725	T7031	T7030	prep	of,contribution
R4726	T7032	T7033	compound	dopamine,D2Rs
R4727	T7033	T7031	pobj	D2Rs,of
R4728	T7034	T7030	prep	to,contribution
R4729	T7035	T7036	compound	reversal,learning
R473	T1187	T1183	cc	or,palatability
R4730	T7036	T7037	compound	learning,behavior
R4731	T7037	T7034	pobj	behavior,to
R4732	T7038	T7026	prep	by,investigated
R4733	T7039	T7038	pcomp	inverting,by
R4734	T7040	T7041	det	the,contingencies
R4735	T7041	T7039	dobj	contingencies,inverting
R4736	T7042	T7041	compound	reinforcement,contingencies
R4737	T7043	T7028	punct	–,signaled
R4738	T7044	T7028	advmod	now,signaled
R4739	T7045	T7046	det	the,S
R474	T1188	T1183	conj	satiety,palatability
R4740	T7046	T7028	nsubj	S,signaled
R4741	T7047	T7046	amod	former,S
R4742	T7048	T7046	punct	+,S
R4743	T7049	T7050	det	no,reinforcer
R4744	T7050	T7028	dobj	reinforcer,signaled
R4745	T7051	T7028	cc	and,signaled
R4746	T7052	T7053	det	the,S
R4747	T7053	T7055	nsubj	S,indicated
R4748	T7054	T7053	amod	previous,S
R4749	T7055	T7028	conj	indicated,signaled
R475	T1189	T1176	punct	),response
R4750	T7056	T7053	punct	-,S
R4751	T7057	T7055	advmod	now,indicated
R4752	T7058	T7059	compound	reinforcement,availability
R4753	T7059	T7055	dobj	availability,indicated
R4754	T7060	T7028	punct	.,signaled
R4755	T7062	T7063	det	This,manipulation
R4756	T7063	T7064	nsubj	manipulation,permits
R4757	T7065	T7066	det	an,evaluation
R4758	T7066	T7064	dobj	evaluation,permits
R4759	T7067	T7066	prep	of,evaluation
R476	T1190	T1164	punct	.,is
R4760	T7068	T7069	det	the,ability
R4761	T7069	T7067	pobj	ability,of
R4762	T7070	T7071	aux	to,inhibit
R4763	T7071	T7069	acl	inhibit,ability
R4764	T7072	T7071	dobj	responses,inhibit
R4765	T7073	T7072	prep	to,responses
R4766	T7074	T7075	advmod	previously,reinforced
R4767	T7075	T7076	amod	reinforced,stimuli
R4768	T7076	T7073	pobj	stimuli,to
R4769	T7077	T7076	amod	discriminative,stimuli
R477	T1192	T1193	det	The,phase
R4770	T7078	T7079	punct	[,18
R4771	T7079	T7071	parataxis	18,inhibit
R4772	T7080	T7079	punct	],18
R4773	T7081	T7064	punct	.,permits
R4774	T7083	T7084	det	The,number
R4775	T7084	T7085	nsubj	number,was
R4776	T7086	T7084	prep	of,number
R4777	T7087	T7086	pobj	trials,of
R4778	T7088	T7084	amod	necessary,number
R4779	T7089	T7090	aux	to,establish
R478	T1193	T1195	nsubj	phase,involves
R4780	T7090	T7088	xcomp	establish,necessary
R4781	T7091	T7092	nummod	8,responses
R4782	T7092	T7090	dobj	responses,establish
R4783	T7093	T7091	prep	out,8
R4784	T7094	T7093	prep	of,out
R4785	T7095	T7094	pobj	10,of
R4786	T7096	T7092	amod	accurate,responses
R4787	T7097	T7098	poss	our,definition
R4788	T7098	T7085	attr	definition,was
R4789	T7099	T7098	prep	of,definition
R479	T1194	T1193	amod	second,phase
R4790	T7100	T7101	amod	successful,learning
R4791	T7101	T7099	pobj	learning,of
R4792	T7102	T7101	compound	reversal,learning
R4793	T7103	T7085	punct	.,was
R4794	T7118	T7119	compound	Data,analysis
R4795	T7121	T7122	det	The,latency
R4796	T7122	T7123	nsubjpass	latency,analyzed
R4797	T7124	T7125	aux	to,retrieve
R4798	T7125	T7122	advcl	retrieve,latency
R4799	T7126	T7127	det	a,pellet
R48	T278	T279	amod	environmental,cues
R480	T1196	T1197	det	the,attachment
R4800	T7127	T7125	dobj	pellet,retrieve
R4801	T7128	T7125	prep	from,retrieve
R4802	T7129	T7130	det	an,dish
R4803	T7130	T7128	pobj	dish,from
R4804	T7131	T7130	amod	empty,dish
R4805	T7132	T7122	punct	", ",latency
R4806	T7133	T7134	det	the,latency
R4807	T7134	T7122	conj	latency,latency
R4808	T7135	T7136	aux	to,dig
R4809	T7136	T7134	advcl	dig,latency
R481	T1197	T1195	dobj	attachment,involves
R4810	T7137	T7136	prep	through,dig
R4811	T7138	T7139	det	a,dish
R4812	T7139	T7137	pobj	dish,through
R4813	T7140	T7139	acl	filled,dish
R4814	T7141	T7140	prep	with,filled
R4815	T7142	T7143	amod	unscented,sand
R4816	T7143	T7141	pobj	sand,with
R4817	T7144	T7134	punct	", ",latency
R4818	T7145	T7134	cc	and,latency
R4819	T7146	T7147	det	the,number
R482	T1198	T1197	prep	of,attachment
R4820	T7147	T7134	conj	number,latency
R4821	T7148	T7147	prep	of,number
R4822	T7149	T7148	pobj	errors,of
R4823	T7150	T7149	prep	of,errors
R4824	T7151	T7150	pobj	commission,of
R4825	T7152	T7149	acl	committed,errors
R4826	T7153	T7152	prep	across,committed
R4827	T7154	T7155	det	the,sessions
R4828	T7155	T7153	pobj	sessions,across
R4829	T7156	T7155	compound	reversal,sessions
R483	T1199	T1198	pobj	salience,of
R4830	T7157	T7123	auxpass	were,analyzed
R4831	T7158	T7123	prep	with,analyzed
R4832	T7159	T7160	nummod	2,way
R4833	T7160	T7162	compound	way,analyses
R4834	T7161	T7160	punct	-,way
R4835	T7162	T7158	pobj	analyses,with
R4836	T7163	T7162	prep	of,analyses
R4837	T7164	T7163	pobj	variance,of
R4838	T7165	T7166	punct	(,trials
R4839	T7166	T7162	parataxis	trials,analyses
R484	T1200	T1197	prep	to,attachment
R4840	T7167	T7166	nmod	genotype,trials
R4841	T7168	T7167	punct	×,genotype
R4842	T7169	T7166	punct	),trials
R4843	T7170	T7123	punct	.,analyzed
R4844	T7172	T7173	det	The,number
R4845	T7173	T7174	nsubjpass	number,separated
R4846	T7175	T7173	prep	of,number
R4847	T7176	T7175	pobj	trials,of
R4848	T7177	T7173	amod	necessary,number
R4849	T7178	T7179	aux	to,attain
R485	T1201	T1202	amod	external,stimuli
R4850	T7179	T7177	xcomp	attain,necessary
R4851	T7180	T7181	compound	criterion,performance
R4852	T7181	T7179	dobj	performance,attain
R4853	T7182	T7181	prep	in,performance
R4854	T7183	T7184	compound	odor,discrimination
R4855	T7184	T7182	pobj	discrimination,in
R4856	T7185	T7186	punct	(,responses
R4857	T7186	T7173	appos	responses,number
R4858	T7187	T7186	nummod	8,responses
R4859	T7188	T7186	amod	correct,responses
R486	T1202	T1200	pobj	stimuli,to
R4860	T7189	T7186	prep	across,responses
R4861	T7190	T7191	nummod	10,trials
R4862	T7191	T7189	pobj	trials,across
R4863	T7192	T7191	amod	consecutive,trials
R4864	T7193	T7186	punct	),responses
R4865	T7194	T7173	cc	and,number
R4866	T7195	T7173	conj	errors,number
R4867	T7196	T7195	acl	committed,errors
R4868	T7197	T7198	mark	while,learning
R4869	T7198	T7196	advcl	learning,committed
R487	T1203	T1202	punct	(,stimuli
R4870	T7199	T7200	det	the,tasks
R4871	T7200	T7198	dobj	tasks,learning
R4872	T7201	T7200	compound	discrimination,tasks
R4873	T7202	T7174	auxpass	were,separated
R4874	T7203	T7174	prep	as,separated
R4875	T7204	T7205	amod	individual,phases
R4876	T7205	T7203	pobj	phases,as
R4877	T7206	T7205	compound	testing,phases
R4878	T7207	T7208	punct	(,discrimination
R4879	T7208	T7205	appos	discrimination,phases
R488	T1204	T1205	amod	discriminative,stimuli
R4880	T7209	T7208	advmod	e.g.,discrimination
R4881	T7210	T7208	compound	odor,discrimination
R4882	T7211	T7208	cc	and,discrimination
R4883	T7212	T7213	compound	reversal,learning
R4884	T7213	T7208	conj	learning,discrimination
R4885	T7214	T7213	punct	),learning
R4886	T7215	T7174	cc	and,separated
R4887	T7216	T7174	conj	analyzed,separated
R4888	T7217	T7216	advmod	separately,analyzed
R4889	T7218	T7216	prep	with,analyzed
R489	T1205	T1202	appos	stimuli,stimuli
R4890	T7219	T7220	amod	unpaired,tests
R4891	T7220	T7218	pobj	tests,with
R4892	T7221	T7222	advmod	2,tailed
R4893	T7222	T7220	amod	tailed,tests
R4894	T7223	T7222	punct	-,tailed
R4895	T7224	T7220	compound	t,tests
R4896	T7225	T7220	punct	-,tests
R4897	T7226	T7174	punct	.,separated
R4898	T7228	T7229	nsubjpass	Significance,established
R4899	T7230	T7229	auxpass	was,established
R49	T279	T277	pobj	cues,to
R490	T1206	T1202	punct	),stimuli
R4900	T7231	T7229	prep	at,established
R4901	T7232	T7231	pobj	p,at
R4902	T7233	T7234	punct	<,0.05
R4903	T7234	T7232	acl	0.05,p
R4904	T7235	T7229	punct	.,established
R4905	T7237	T7238	nsubjpass	Errors,separated
R4906	T7239	T7237	acl	committed,Errors
R4907	T7240	T7239	prep	during,committed
R4908	T7241	T7242	compound	reversal,trials
R4909	T7242	T7240	pobj	trials,during
R491	T1207	T1208	dep	that,signal
R4910	T7243	T7238	auxpass	were,separated
R4911	T7244	T7238	advmod	further,separated
R4912	T7245	T7238	advmod	categorically,separated
R4913	T7246	T7238	prep	as,separated
R4914	T7247	T7246	pobj	errors,as
R4915	T7248	T7247	prep	of,errors
R4916	T7249	T7248	pobj	commission,of
R4917	T7250	T7251	punct	(,failing
R4918	T7251	T7247	parataxis	failing,errors
R4919	T7252	T7253	aux	to,withhold
R492	T1208	T1202	relcl	signal,stimuli
R4920	T7253	T7251	xcomp	withhold,failing
R4921	T7254	T7253	xcomp	responding,withhold
R4922	T7255	T7254	prep	to,responding
R4923	T7256	T7255	pobj	S,to
R4924	T7257	T7256	punct	-,S
R4925	T7258	T7251	punct	),failing
R4926	T7259	T7247	cc	and,errors
R4927	T7260	T7247	conj	errors,errors
R4928	T7261	T7260	prep	of,errors
R4929	T7262	T7261	pobj	omission,of
R493	T1209	T1210	mark	whether,will
R4930	T7263	T7264	punct	(,failing
R4931	T7264	T7260	parataxis	failing,errors
R4932	T7265	T7266	aux	to,dig
R4933	T7266	T7264	xcomp	dig,failing
R4934	T7267	T7266	prep	in,dig
R4935	T7268	T7269	det	either,dish
R4936	T7269	T7267	pobj	dish,in
R4937	T7270	T7271	mark	after,expired
R4938	T7271	T7266	advcl	expired,dig
R4939	T7272	T7273	nummod	3,min
R494	T1210	T1208	ccomp	will,signal
R4940	T7273	T7271	nsubj	min,expired
R4941	T7274	T7273	punct	-,min
R4942	T7275	T7271	aux	had,expired
R4943	T7276	T7264	punct	),failing
R4944	T7277	T7238	punct	.,separated
R4945	T7279	T7280	amod	Categorical,errors
R4946	T7280	T7281	nsubjpass	errors,analyzed
R4947	T7282	T7280	cc	and,errors
R4948	T7283	T7280	conj	number,errors
R4949	T7284	T7283	prep	of,number
R495	T1211	T1212	det	the,delivery
R4950	T7285	T7286	compound	commission,errors
R4951	T7286	T7284	pobj	errors,of
R4952	T7287	T7286	acl	committed,errors
R4953	T7288	T7287	prep	during,committed
R4954	T7289	T7290	det	the,session
R4955	T7290	T7288	pobj	session,during
R4956	T7291	T7290	amod	first,session
R4957	T7292	T7293	compound	reversal,learning
R4958	T7293	T7290	compound	learning,session
R4959	T7294	T7281	auxpass	were,analyzed
R496	T1212	T1210	nsubj	delivery,will
R4960	T7295	T7281	prep	between,analyzed
R4961	T7296	T7295	pobj	groups,between
R4962	T7297	T7296	prep	with,groups
R4963	T7298	T7299	amod	nonparametric,tests
R4964	T7299	T7297	pobj	tests,with
R4965	T7300	T7301	compound	Mann,Whitney
R4966	T7301	T7299	compound	Whitney,tests
R4967	T7302	T7301	punct	-,Whitney
R4968	T7303	T7299	compound	U,tests
R4969	T7304	T7281	punct	.,analyzed
R497	T1213	T1212	prep	of,delivery
R498	T1214	T1215	det	a,reinforcer
R499	T1215	T1213	pobj	reinforcer,of
R50	T280	T281	dep	that,signal
R500	T1216	T1215	amod	primary,reinforcer
R501	T1217	T1210	cc	or,will
R502	T1218	T1210	conj	will,will
R503	T1219	T1218	neg	not,will
R504	T1220	T1218	dep	occur,will
R505	T1221	T1208	prep	based,signal
R506	T1222	T1221	prep	on,based
R507	T1223	T1224	det	some,behavior
R508	T1224	T1222	pobj	behavior,on
R509	T1225	T1224	amod	emitted,behavior
R51	T281	T279	relcl	signal,cues
R510	T1226	T1227	punct	(,presses
R511	T1227	T1224	parataxis	presses,behavior
R512	T1228	T1227	advmod	e.g.,presses
R513	T1229	T1230	det	a,rodent
R514	T1230	T1227	nsubj	rodent,presses
R515	T1231	T1227	dep	lever,presses
R516	T1232	T1227	prep	for,presses
R517	T1233	T1234	compound	food,pellets
R518	T1234	T1232	pobj	pellets,for
R519	T1235	T1236	advmod	only,illuminated
R52	T282	T283	amod	causal,relationships
R520	T1236	T1227	advcl	illuminated,presses
R521	T1237	T1236	advmod	when,illuminated
R522	T1238	T1239	det	a,light
R523	T1239	T1236	nsubjpass	light,illuminated
R524	T1240	T1239	compound	stimulus,light
R525	T1241	T1236	auxpass	is,illuminated
R526	T1242	T1236	prep	in,illuminated
R527	T1243	T1244	det	an,chamber
R528	T1244	T1242	pobj	chamber,in
R529	T1245	T1244	compound	operant,chamber
R53	T283	T281	dobj	relationships,signal
R530	T1246	T1227	punct	),presses
R531	T1247	T1195	punct	.,involves
R532	T1249	T1250	advmod	Finally,is
R533	T1251	T1250	punct	", ",is
R534	T1252	T1250	expl	there,is
R535	T1253	T1254	det	the,maintenance
R536	T1254	T1250	attr	maintenance,is
R537	T1255	T1254	prep	of,maintenance
R538	T1256	T1257	amod	associative,learning
R539	T1257	T1258	compound	learning,relationships
R54	T284	T275	punct	", ",attaching
R540	T1258	T1255	pobj	relationships,of
R541	T1259	T1254	prep	over,maintenance
R542	T1260	T1259	pobj	time,over
R543	T1261	T1262	punct	(,signifies
R544	T1262	T1250	parataxis	signifies,is
R545	T1263	T1264	det	a,light
R546	T1264	T1262	nsubj	light,signifies
R547	T1265	T1264	compound	stimulus,light
R548	T1266	T1262	advmod	always,signifies
R549	T1267	T1268	det	a,pellet
R55	T285	T286	advmod	thereby,guiding
R550	T1268	T1270	nsubj	pellet,is
R551	T1269	T1268	compound	food,pellet
R552	T1270	T1262	advcl	is,signifies
R553	T1271	T1270	acomp	available,is
R554	T1272	T1273	amod	subsequent,to
R555	T1273	T1270	prep	to,is
R556	T1274	T1275	det	a,press
R557	T1275	T1273	pobj	press,to
R558	T1276	T1275	compound	lever,press
R559	T1277	T1262	punct	),signifies
R56	T286	T275	advcl	guiding,attaching
R560	T1278	T1279	punct	[,see
R561	T1279	T1250	parataxis	see,is
R562	T1280	T1281	nmod	refs.,2
R563	T1281	T1279	dobj	2,see
R564	T1282	T1281	punct	[,2
R565	T1283	T1281	nummod	1,2
R566	T1284	T1281	punct	",",2
R567	T1285	T1281	punct	],2
R568	T1286	T1279	prep	for,see
R569	T1287	T1286	pobj	review,for
R57	T287	T288	npadvmod	goal,directed
R570	T1288	T1279	punct	],see
R571	T1289	T1250	punct	.,is
R572	T1291	T1292	nsubj	Berridge,proposed
R573	T1293	T1291	cc	and,Berridge
R574	T1294	T1291	conj	Robinson,Berridge
R575	T1295	T1296	punct	[,1
R576	T1296	T1294	parataxis	1,Robinson
R577	T1297	T1296	punct	],1
R578	T1298	T1292	aux	have,proposed
R579	T1299	T1300	mark	that,plays
R58	T288	T290	amod	directed,behaviors
R580	T1300	T1292	ccomp	plays,proposed
R581	T1301	T1300	nsubj	dopamine,plays
R582	T1302	T1303	det	a,role
R583	T1303	T1300	dobj	role,plays
R584	T1304	T1303	amod	pivotal,role
R585	T1305	T1300	prep	in,plays
R586	T1306	T1307	det	the,phase
R587	T1307	T1305	pobj	phase,in
R588	T1308	T1307	amod	second,phase
R589	T1309	T1307	prep	of,phase
R59	T289	T288	punct	-,directed
R590	T1310	T1311	npadvmod	reinforcement,mediated
R591	T1311	T1313	amod	mediated,learning
R592	T1312	T1311	punct	-,mediated
R593	T1313	T1309	pobj	learning,of
R594	T1314	T1313	amod	associative,learning
R595	T1315	T1300	prep	by,plays
R596	T1316	T1315	pcomp	molding,by
R597	T1317	T1318	det	the,salience
R598	T1318	T1316	dobj	salience,molding
R599	T1319	T1318	punct	"""",salience
R60	T290	T286	dobj	behaviors,guiding
R600	T1320	T1318	compound	incentive,salience
R601	T1321	T1318	punct	"""",salience
R602	T1322	T1318	cc	or,salience
R603	T1323	T1324	amod	learned,properties
R604	T1324	T1318	conj	properties,salience
R605	T1325	T1324	amod	motivational,properties
R606	T1326	T1318	prep	of,salience
R607	T1327	T1328	amod	conditioned,stimuli
R608	T1328	T1326	pobj	stimuli,of
R609	T1329	T1292	punct	.,proposed
R61	T291	T290	punct	", ",behaviors
R610	T1331	T1332	prep	In,are
R611	T1333	T1331	pobj	support,In
R612	T1334	T1333	prep	of,support
R613	T1335	T1336	det	this,view
R614	T1336	T1334	pobj	view,of
R615	T1337	T1338	amod	several,studies
R616	T1338	T1332	nsubj	studies,are
R617	T1339	T1338	acl	demonstrating,studies
R618	T1340	T1341	mark	that,disrupt
R619	T1341	T1339	ccomp	disrupt,demonstrating
R62	T292	T290	amod	adaptable,behaviors
R620	T1342	T1343	det	the,disruption
R621	T1343	T1341	nsubj	disruption,disrupt
R622	T1344	T1343	prep	of,disruption
R623	T1345	T1346	compound	dopamine,signaling
R624	T1346	T1344	pobj	signaling,of
R625	T1347	T1343	prep	via,disruption
R626	T1348	T1349	amod	acute,blockade
R627	T1349	T1347	pobj	blockade,via
R628	T1350	T1349	prep	of,blockade
R629	T1351	T1352	compound	dopamine,receptors
R63	T293	T252	punct	.,is
R630	T1352	T1350	pobj	receptors,of
R631	T1353	T1349	prep	with,blockade
R632	T1354	T1355	compound	dopamine,receptor
R633	T1355	T1356	compound	receptor,antagonists
R634	T1356	T1353	pobj	antagonists,with
R635	T1357	T1358	punct	[,3
R636	T1358	T1356	parataxis	3,antagonists
R637	T1359	T1360	punct	-,9
R638	T1360	T1358	prep	9,3
R639	T1361	T1358	punct	],3
R64	T295	T296	prep	At,mediated
R640	T1362	T1356	cc	or,antagonists
R641	T1363	T1364	nummod	6,OHDA
R642	T1364	T1366	compound	OHDA,lesions
R643	T1365	T1364	punct	-,OHDA
R644	T1366	T1356	conj	lesions,antagonists
R645	T1367	T1368	punct	[,11
R646	T1368	T1366	parataxis	11,lesions
R647	T1369	T1368	nummod	1,11
R648	T1370	T1368	punct	",",11
R649	T1371	T1368	nummod	10,11
R65	T297	T298	det	the,level
R650	T1372	T1368	punct	",",11
R651	T1373	T1368	punct	],11
R652	T1374	T1341	aux	do,disrupt
R653	T1375	T1341	neg	not,disrupt
R654	T1376	T1341	dobj	phase,disrupt
R655	T1377	T1376	nummod	1,phase
R656	T1378	T1376	punct	", ",phase
R657	T1379	T1380	det	the,palatability
R658	T1380	T1376	appos	palatability,phase
R659	T1381	T1380	cc	or,palatability
R66	T298	T295	pobj	level,At
R660	T1382	T1383	amod	primary,characteristics
R661	T1383	T1380	conj	characteristics,palatability
R662	T1384	T1383	amod	reinforcing,characteristics
R663	T1385	T1383	prep	of,characteristics
R664	T1386	T1387	det	a,reinforcer
R665	T1387	T1385	pobj	reinforcer,of
R666	T1388	T1387	amod	natural,reinforcer
R667	T1389	T1390	punct	(,palatability
R668	T1390	T1383	appos	palatability,characteristics
R669	T1391	T1390	advmod	e.g.,palatability
R67	T299	T298	amod	cellular,level
R670	T1392	T1390	punct	),palatability
R671	T1393	T1341	cc	but,disrupt
R672	T1394	T1341	conj	disrupt,disrupt
R673	T1395	T1394	dobj	phase,disrupt
R674	T1396	T1395	nummod	2,phase
R675	T1397	T1395	punct	", ",phase
R676	T1398	T1399	det	the,formation
R677	T1399	T1395	appos	formation,phase
R678	T1400	T1399	prep	of,formation
R679	T1401	T1402	compound	incentive,salience
R68	T300	T296	punct	", ",mediated
R680	T1402	T1400	pobj	salience,of
R681	T1403	T1332	punct	.,are
R682	T1405	T1406	compound	Dopamine,signaling
R683	T1406	T1407	nsubjpass	signaling,mediated
R684	T1408	T1407	auxpass	is,mediated
R685	T1409	T1407	prep	at,mediated
R686	T1410	T1411	det	the,level
R687	T1411	T1409	pobj	level,at
R688	T1412	T1411	amod	cellular,level
R689	T1413	T1407	agent	by,mediated
R69	T301	T302	compound	dopamine,signaling
R690	T1414	T1415	nummod	two,subclasses
R691	T1415	T1413	pobj	subclasses,by
R692	T1416	T1415	amod	major,subclasses
R693	T1417	T1415	prep	of,subclasses
R694	T1418	T1419	compound	G,protein
R695	T1419	T1421	npadvmod	protein,coupled
R696	T1420	T1419	punct	-,protein
R697	T1421	T1422	amod	coupled,receptors
R698	T1422	T1417	pobj	receptors,of
R699	T1423	T1424	dep	that,referred
R7	T230	T232	compound	D2,receptors
R70	T302	T296	nsubjpass	signaling,mediated
R700	T1424	T1415	relcl	referred,subclasses
R701	T1425	T1424	auxpass	are,referred
R702	T1426	T1424	prep	to,referred
R703	T1427	T1424	prep	as,referred
R704	T1428	T1429	npadvmod	D,like
R705	T1429	T1427	amod	like,as
R706	T1430	T1428	punct	-,D
R707	T1431	T1428	nummod	1,D
R708	T1432	T1433	punct	(,D1aR
R709	T1433	T1429	parataxis	D1aR,like
R71	T303	T296	auxpass	is,mediated
R710	T1434	T1433	punct	", ",D1aR
R711	T1435	T1436	compound	D1b,5R
R712	T1436	T1433	appos	5R,D1aR
R713	T1437	T1436	punct	/,5R
R714	T1438	T1433	punct	),D1aR
R715	T1439	T1429	cc	or,like
R716	T1440	T1441	npadvmod	D,like
R717	T1441	T1429	conj	like,like
R718	T1442	T1440	punct	-,D
R719	T1443	T1440	nummod	2,D
R72	T304	T296	prep	through,mediated
R720	T1444	T1445	punct	(,D4R
R721	T1445	T1441	parataxis	D4R,like
R722	T1446	T1445	nmod	D2R,D4R
R723	T1447	T1445	punct	", ",D4R
R724	T1448	T1445	nmod	D3R,D4R
R725	T1449	T1445	punct	", ",D4R
R726	T1450	T1445	punct	),D4R
R727	T1451	T1452	punct	[,13
R728	T1452	T1407	parataxis	13,mediated
R729	T1453	T1452	nummod	12,13
R73	T305	T306	npadvmod	D1,like
R730	T1454	T1452	punct	",",13
R731	T1455	T1452	punct	],13
R732	T1456	T1407	punct	.,mediated
R733	T1458	T1459	mark	Although,code
R734	T1459	T1462	advcl	code,is
R735	T1460	T1461	amod	individual,genes
R736	T1461	T1459	nsubj	genes,code
R737	T1463	T1459	prep	for,code
R738	T1464	T1465	det	each,subtype
R739	T1465	T1463	pobj	subtype,for
R74	T306	T308	amod	like,receptors
R740	T1466	T1467	compound	dopamine,receptor
R741	T1467	T1465	compound	receptor,subtype
R742	T1468	T1462	punct	", ",is
R743	T1469	T1462	expl	there,is
R744	T1470	T1471	amod	considerable,overlap
R745	T1471	T1462	attr	overlap,is
R746	T1472	T1471	amod	pharmacological,overlap
R747	T1473	T1471	prep	between,overlap
R748	T1474	T1475	npadvmod	D1,like
R749	T1475	T1477	amod	like,receptors
R75	T307	T306	punct	-,like
R750	T1476	T1475	punct	-,like
R751	T1477	T1473	pobj	receptors,between
R752	T1478	T1475	cc	and,like
R753	T1479	T1480	npadvmod	D2,like
R754	T1480	T1475	conj	like,like
R755	T1481	T1480	punct	-,like
R756	T1482	T1462	punct	.,is
R757	T1484	T1485	amod	Several,studies
R758	T1485	T1486	nsubj	studies,used
R759	T1487	T1486	aux	have,used
R76	T308	T304	pobj	receptors,through
R760	T1488	T1489	amod	pharmacological,manipulations
R761	T1489	T1486	dobj	manipulations,used
R762	T1490	T1491	aux	to,investigate
R763	T1491	T1486	advcl	investigate,used
R764	T1492	T1493	det	the,contribution
R765	T1493	T1491	dobj	contribution,investigate
R766	T1494	T1493	prep	of,contribution
R767	T1495	T1496	compound	dopamine,receptor
R768	T1496	T1497	compound	receptor,subtypes
R769	T1497	T1494	pobj	subtypes,of
R77	T309	T306	cc	or,like
R770	T1498	T1493	prep	in,contribution
R771	T1499	T1500	amod	various,stages
R772	T1500	T1498	pobj	stages,in
R773	T1501	T1500	prep	of,stages
R774	T1502	T1503	amod	associative,learning
R775	T1503	T1501	pobj	learning,of
R776	T1504	T1505	punct	[,14
R777	T1505	T1503	parataxis	14,learning
R778	T1506	T1505	nummod	1,14
R779	T1507	T1505	punct	",",14
R78	T310	T311	npadvmod	D2,like
R780	T1508	T1505	nummod	2,14
R781	T1509	T1505	punct	",",14
R782	T1510	T1505	punct	],14
R783	T1511	T1486	punct	.,used
R784	T1513	T1514	advmod	Currently,held
R785	T1515	T1514	nsubjpass	it,held
R786	T1516	T1514	auxpass	is,held
R787	T1517	T1518	mark	that,mediate
R788	T1518	T1514	ccomp	mediate,held
R789	T1519	T1520	amod	excitatory,D1Rs
R79	T311	T306	conj	like,like
R790	T1520	T1518	nsubj	D1Rs,mediate
R791	T1521	T1520	compound	dopamine,D1Rs
R792	T1522	T1523	det	the,acquisition
R793	T1523	T1518	dobj	acquisition,mediate
R794	T1524	T1523	cc	and,acquisition
R795	T1525	T1523	conj	expression,acquisition
R796	T1526	T1523	prep	of,acquisition
R797	T1527	T1528	amod	several,behaviors
R798	T1528	T1526	pobj	behaviors,of
R799	T1529	T1528	amod	conditioned,behaviors
R8	T232	T233	nsubj	receptors,mediate
R80	T312	T311	punct	-,like
R800	T1530	T1528	acl	involving,behaviors
R801	T1531	T1532	compound	food,reinforcers
R802	T1532	T1530	dobj	reinforcers,involving
R803	T1533	T1534	punct	[,7
R804	T1534	T1530	parataxis	7,involving
R805	T1535	T1534	advmod	e.g.,7
R806	T1536	T1534	punct	[,7
R807	T1537	T1534	nummod	6,7
R808	T1538	T1534	punct	",",7
R809	T1539	T1534	punct	],7
R81	T313	T296	punct	.,mediated
R810	T1540	T1534	punct	],7
R811	T1541	T1542	advmod	as,as
R812	T1542	T1530	cc	as,involving
R813	T1543	T1542	advmod	well,as
R814	T1544	T1530	conj	responding,involving
R815	T1545	T1544	prep	for,responding
R816	T1546	T1547	amod	conditioned,cues
R817	T1547	T1545	pobj	cues,for
R818	T1548	T1547	amod	predictive,cues
R819	T1549	T1548	prep	of,predictive
R82	T315	T316	mark	Although,identified
R820	T1550	T1551	compound	cocaine,delivery
R821	T1551	T1549	pobj	delivery,of
R822	T1552	T1553	punct	[,9
R823	T1553	T1551	parataxis	9,delivery
R824	T1554	T1553	punct	],9
R825	T1555	T1518	punct	–,mediate
R826	T1556	T1518	advcl	consistent,mediate
R827	T1557	T1556	prep	with,consistent
R828	T1558	T1559	det	the,interpretation
R829	T1559	T1557	pobj	interpretation,with
R83	T316	T334	advcl	identified,established
R830	T1560	T1561	mark	that,modulate
R831	T1561	T1559	acl	modulate,interpretation
R832	T1562	T1563	npadvmod	D1R,mediated
R833	T1563	T1564	amod	mediated,signaling
R834	T1564	T1561	nsubj	signaling,modulate
R835	T1565	T1561	aux	might,modulate
R836	T1566	T1567	det	the,maintenance
R837	T1567	T1561	dobj	maintenance,modulate
R838	T1568	T1567	prep	of,maintenance
R839	T1569	T1570	compound	stimulus,response
R84	T317	T318	det	a,role
R840	T1570	T1572	compound	response,outcomes
R841	T1571	T1570	punct	-,response
R842	T1572	T1568	pobj	outcomes,of
R843	T1573	T1514	punct	.,held
R844	T1575	T1576	prep	Despite,is
R845	T1577	T1578	det	a,literature
R846	T1578	T1575	pobj	literature,Despite
R847	T1579	T1578	amod	growing,literature
R848	T1580	T1578	acl	demonstrating,literature
R849	T1581	T1582	amod	disrupted,learning
R85	T318	T316	nsubjpass	role,identified
R850	T1582	T1580	dobj	learning,demonstrating
R851	T1583	T1582	amod	associative,learning
R852	T1584	T1582	acl	following,learning
R853	T1585	T1586	amod	acute,manipulations
R854	T1586	T1584	dobj	manipulations,following
R855	T1587	T1586	prep	of,manipulations
R856	T1588	T1589	compound	dopamine,D1R
R857	T1589	T1590	compound	D1R,signaling
R858	T1590	T1587	pobj	signaling,of
R859	T1591	T1586	prep	during,manipulations
R86	T319	T318	prep	for,role
R860	T1592	T1591	pobj	acquisition,during
R861	T1593	T1592	prep	of,acquisition
R862	T1594	T1595	amod	associative,learning
R863	T1595	T1596	compound	learning,tasks
R864	T1596	T1593	pobj	tasks,of
R865	T1597	T1592	prep	with,acquisition
R866	T1598	T1597	pobj	food,with
R867	T1599	T1600	punct	[,7
R868	T1600	T1592	parataxis	7,acquisition
R869	T1601	T1600	advmod	e.g.,7
R87	T320	T321	npadvmod	D1,like
R870	T1602	T1600	punct	[,7
R871	T1603	T1600	nummod	6,7
R872	T1604	T1600	punct	",",7
R873	T1605	T1600	punct	],7
R874	T1606	T1600	punct	],7
R875	T1607	T1576	punct	", ",is
R876	T1608	T1609	det	the,contribution
R877	T1609	T1576	nsubj	contribution,is
R878	T1610	T1609	amod	actual,contribution
R879	T1611	T1609	prep	of,contribution
R88	T321	T323	amod	like,receptors
R880	T1612	T1613	npadvmod	D2R,mediated
R881	T1613	T1615	amod	mediated,signaling
R882	T1614	T1613	punct	-,mediated
R883	T1615	T1611	pobj	signaling,of
R884	T1616	T1609	prep	on,contribution
R885	T1617	T1616	pobj	acquisition,on
R886	T1618	T1617	cc	and,acquisition
R887	T1619	T1617	conj	maintenance,acquisition
R888	T1620	T1617	prep	of,acquisition
R889	T1621	T1622	amod	associative,learning
R89	T322	T321	punct	-,like
R890	T1622	T1620	pobj	learning,of
R891	T1623	T1622	prep	in,learning
R892	T1624	T1623	pobj	rodents,in
R893	T1625	T1576	acomp	unresolved,is
R894	T1626	T1576	punct	.,is
R895	T1628	T1629	mark	While,used
R896	T1629	T1634	advcl	used,prevented
R897	T1630	T1631	compound	D2R,antagonists
R898	T1631	T1629	nsubjpass	antagonists,used
R899	T1632	T1629	aux	have,used
R9	T234	T235	nummod	two,odor
R90	T323	T319	pobj	receptors,for
R900	T1633	T1629	auxpass	been,used
R901	T1635	T1629	prep	in,used
R902	T1636	T1637	det	the,context
R903	T1637	T1635	pobj	context,in
R904	T1638	T1637	prep	of,context
R905	T1639	T1640	nmod	rodent,paradigms
R906	T1640	T1638	pobj	paradigms,of
R907	T1641	T1642	amod	associative,learning
R908	T1642	T1640	compound	learning,paradigms
R909	T1643	T1634	punct	", ",prevented
R91	T324	T318	prep	in,role
R910	T1644	T1645	poss	their,lack
R911	T1645	T1634	nsubj	lack,prevented
R912	T1646	T1645	prep	of,lack
R913	T1647	T1648	compound	receptor,subtype
R914	T1648	T1649	compound	subtype,specificity
R915	T1649	T1646	pobj	specificity,of
R916	T1650	T1651	punct	[,13
R917	T1651	T1649	parataxis	13,specificity
R918	T1652	T1651	punct	],13
R919	T1653	T1649	cc	and,specificity
R92	T325	T326	det	a,variety
R920	T1654	T1655	npadvmod	motor,disrupting
R921	T1655	T1657	amod	disrupting,effects
R922	T1656	T1655	punct	-,disrupting
R923	T1657	T1649	conj	effects,specificity
R924	T1658	T1659	punct	[,8
R925	T1659	T1657	parataxis	8,effects
R926	T1660	T1659	nummod	6,8
R927	T1661	T1659	punct	",",8
R928	T1662	T1659	punct	],8
R929	T1663	T1634	aux	have,prevented
R93	T326	T324	pobj	variety,in
R930	T1664	T1665	det	a,examination
R931	T1665	T1634	dobj	examination,prevented
R932	T1666	T1665	amod	rigorous,examination
R933	T1667	T1665	prep	of,examination
R934	T1668	T1669	det	the,role
R935	T1669	T1667	pobj	role,of
R936	T1670	T1669	amod	actual,role
R937	T1671	T1672	det	this,subtype
R938	T1672	T1675	nsubj	subtype,plays
R939	T1673	T1674	compound	dopamine,receptor
R94	T327	T326	prep	of,variety
R940	T1674	T1672	compound	receptor,subtype
R941	T1675	T1669	advcl	plays,role
R942	T1676	T1675	prep	in,plays
R943	T1677	T1678	amod	associative,learning
R944	T1678	T1676	pobj	learning,in
R945	T1679	T1677	cc	and,associative
R946	T1680	T1677	conj	reversal,associative
R947	T1681	T1675	prep	in,plays
R948	T1682	T1683	det	the,context
R949	T1683	T1681	pobj	context,in
R95	T328	T329	npadvmod	goal,directed
R950	T1684	T1683	prep	of,context
R951	T1685	T1686	det	an,behavior
R952	T1686	T1684	pobj	behavior,of
R953	T1687	T1686	compound	operant,behavior
R954	T1688	T1634	punct	.,prevented
R955	T1690	T1691	amod	Past,experiments
R956	T1691	T1692	nsubj	experiments,utilized
R957	T1693	T1691	acl	seeking,experiments
R958	T1694	T1695	aux	to,explore
R959	T1695	T1693	xcomp	explore,seeking
R96	T329	T331	amod	directed,behaviors
R960	T1696	T1697	det	the,involvement
R961	T1697	T1695	dobj	involvement,explore
R962	T1698	T1697	amod	possible,involvement
R963	T1699	T1697	prep	of,involvement
R964	T1700	T1701	compound	dopamine,D2Rs
R965	T1701	T1699	pobj	D2Rs,of
R966	T1702	T1697	prep	in,involvement
R967	T1703	T1704	amod	associative,learning
R968	T1704	T1702	pobj	learning,in
R969	T1705	T1692	aux	have,utilized
R97	T330	T329	punct	-,directed
R970	T1706	T1707	amod	low,doses
R971	T1707	T1692	dobj	doses,utilized
R972	T1708	T1706	prep	to,low
R973	T1709	T1708	amod	moderate,to
R974	T1710	T1707	prep	of,doses
R975	T1711	T1710	pobj	drugs,of
R976	T1712	T1713	punct	[,6
R977	T1713	T1707	parataxis	6,doses
R978	T1714	T1713	nummod	2,6
R979	T1715	T1713	punct	",",6
R98	T331	T327	pobj	behaviors,of
R980	T1716	T1713	nummod	5,6
R981	T1717	T1713	punct	",",6
R982	T1718	T1713	punct	],6
R983	T1719	T1707	cc	and,doses
R984	T1720	T1721	npadvmod	site,specific
R985	T1721	T1723	amod	specific,administration
R986	T1722	T1721	punct	-,specific
R987	T1723	T1707	conj	administration,doses
R988	T1724	T1725	punct	[,9
R989	T1725	T1723	parataxis	9,administration
R99	T332	T316	aux	has,identified
R990	T1726	T1725	nummod	7,9
R991	T1727	T1725	punct	",",9
R992	T1728	T1725	punct	],9
R993	T1729	T1692	prep	in,utilized
R994	T1730	T1729	pobj	order,in
R995	T1731	T1732	aux	to,avoid
R996	T1732	T1730	acl	avoid,order
R997	T1733	T1734	det	the,effect
R998	T1734	T1732	dobj	effect,avoid
R999	T1735	T1734	amod	confounding,effect

PMC:400732 JSONTXT 8 Projects

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PMC:400732 JSON TXT 8 Projects