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PMC:394351 / 32227-33014 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T9274 0-2 TO denotes To
T9275 3-9 VB denotes verify
T9277 10-17 IN denotes whether
T9279 18-21 DT denotes the
T9281 22-26 NN denotes mRNA
T9280 27-34 NNS denotes changes
T9278 35-43 VBD denotes resulted
T9282 44-46 IN denotes in
T9283 47-57 NN denotes alteration
T9284 58-60 IN denotes of
T9285 61-64 DT denotes the
T9287 65-71 NN denotes enzyme
T9288 72-80 NN denotes activity
T9286 81-88 NNS denotes changes
T9289 88-90 , denotes ,
T9290 90-95 NN denotes liver
T9291 96-103 NNS denotes samples
T9292 104-108 VBD denotes were
T9276 109-117 VBN denotes analyzed
T9293 118-121 IN denotes for
T9294 122-125 NN denotes HMG
T9296 125-126 HYPH denotes -
T9295 126-129 NN denotes CoA
T9297 130-139 NN denotes reductase
T9298 140-148 NN denotes activity
T9299 149-152 CC denotes and
T9300 153-159 NN denotes Cyp7a1
T9301 160-168 NN denotes activity
T9302 169-170 -LRB- denotes (
T9304 170-176 NN denotes Figure
T9303 177-179 NN denotes 4b
T9305 179-180 -RRB- denotes )
T9306 180-181 . denotes .
T9307 181-347 sentence denotes HMG-CoA reductase activity was reduced by 30% and 60% in the Abcg8+/- and Abcg8-/- mice, respectively (Figure 4b), and thus reflected the changes in mRNA expression.
T9308 182-185 NN denotes HMG
T9310 185-186 HYPH denotes -
T9309 186-189 NN denotes CoA
T9311 190-199 NN denotes reductase
T9312 200-208 NN denotes activity
T9314 209-212 VBD denotes was
T9313 213-220 VBN denotes reduced
T9315 221-223 IN denotes by
T9316 224-226 CD denotes 30
T9317 226-227 NN denotes %
T9318 228-231 CC denotes and
T9319 232-234 CD denotes 60
T9320 234-235 NN denotes %
T9321 236-238 IN denotes in
T9322 239-242 DT denotes the
T9324 243-248 NN denotes Abcg8
T9325 248-249 SYM denotes +
T9326 249-250 HYPH denotes /
T9327 250-251 SYM denotes -
T9328 252-255 CC denotes and
T9329 256-261 NN denotes Abcg8
T9330 261-262 SYM denotes -
T9331 262-263 HYPH denotes /
T9332 263-264 SYM denotes -
T9323 265-269 NNS denotes mice
T9333 269-271 , denotes ,
T9334 271-283 RB denotes respectively
T9335 284-285 -LRB- denotes (
T9337 285-291 NN denotes Figure
T9336 292-294 NN denotes 4b
T9338 294-295 -RRB- denotes )
T9339 295-297 , denotes ,
T9340 297-300 CC denotes and
T9341 301-305 RB denotes thus
T9342 306-315 VBD denotes reflected
T9343 316-319 DT denotes the
T9344 320-327 NNS denotes changes
T9345 328-330 IN denotes in
T9346 331-335 NN denotes mRNA
T9347 336-346 NN denotes expression
T9348 346-347 . denotes .
T9349 347-516 sentence denotes In contrast, although the Cyp7a1 mRNA expression levels were essentially unchanged in the knockout mouse, Cyp7a1 activity was significantly decreased by 37% (P < 0.01).
T9350 348-350 IN denotes In
T9352 351-359 NN denotes contrast
T9353 359-361 , denotes ,
T9354 361-369 IN denotes although
T9356 370-373 DT denotes the
T9358 374-380 NN denotes Cyp7a1
T9359 381-385 NN denotes mRNA
T9360 386-396 NN denotes expression
T9357 397-403 NNS denotes levels
T9355 404-408 VBD denotes were
T9361 409-420 RB denotes essentially
T9362 421-430 JJ denotes unchanged
T9363 431-433 IN denotes in
T9364 434-437 DT denotes the
T9366 438-446 NN denotes knockout
T9365 447-452 NN denotes mouse
T9367 452-454 , denotes ,
T9368 454-460 NN denotes Cyp7a1
T9369 461-469 NN denotes activity
T9370 470-473 VBD denotes was
T9371 474-487 RB denotes significantly
T9351 488-497 VBN denotes decreased
T9372 498-500 IN denotes by
T9373 501-503 CD denotes 37
T9374 503-504 NN denotes %
T9375 505-506 -LRB- denotes (
T9377 506-507 NN denotes P
T9378 508-509 SYM denotes <
T9376 510-514 CD denotes 0.01
T9379 514-515 -RRB- denotes )
T9380 515-516 . denotes .
T9381 516-595 sentence denotes In the heterozygous mice, both the mRNA and activity of Cyp7a1 were decreased.
T9382 517-519 IN denotes In
T9384 520-523 DT denotes the
T9386 524-536 JJ denotes heterozygous
T9385 537-541 NNS denotes mice
T9387 541-543 , denotes ,
T9388 543-547 CC denotes both
T9390 548-551 DT denotes the
T9389 552-556 NN denotes mRNA
T9391 557-560 CC denotes and
T9392 561-569 NN denotes activity
T9393 570-572 IN denotes of
T9394 573-579 NN denotes Cyp7a1
T9395 580-584 VBD denotes were
T9383 585-594 VBN denotes decreased
T9396 594-595 . denotes .
T9397 595-787 sentence denotes Sitosterol is known to be a direct competitive inhibitor of Cyp7a1 and it is likely that the elevated plant sterols in the liver are responsible for the inhibition in the knockout mouse [39].
T9398 596-606 NN denotes Sitosterol
T9400 607-609 VBZ denotes is
T9399 610-615 VBN denotes known
T9401 616-618 TO denotes to
T9402 619-621 VB denotes be
T9403 622-623 DT denotes a
T9405 624-630 JJ denotes direct
T9406 631-642 JJ denotes competitive
T9404 643-652 NN denotes inhibitor
T9407 653-655 IN denotes of
T9408 656-662 NN denotes Cyp7a1
T9409 663-666 CC denotes and
T9410 667-669 PRP denotes it
T9411 670-672 VBZ denotes is
T9412 673-679 JJ denotes likely
T9413 680-684 IN denotes that
T9415 685-688 DT denotes the
T9417 689-697 JJ denotes elevated
T9418 698-703 NN denotes plant
T9416 704-711 NNS denotes sterols
T9419 712-714 IN denotes in
T9420 715-718 DT denotes the
T9421 719-724 NN denotes liver
T9414 725-728 VBP denotes are
T9422 729-740 JJ denotes responsible
T9423 741-744 IN denotes for
T9424 745-748 DT denotes the
T9425 749-759 NN denotes inhibition
T9426 760-762 IN denotes in
T9427 763-766 DT denotes the
T9429 767-775 NN denotes knockout
T9428 776-781 NN denotes mouse
T9430 782-783 -LRB- denotes [
T9431 783-785 CD denotes 39
T9432 785-786 -RRB- denotes ]
T9433 786-787 . denotes .
R6136 T9274 T9275 aux To,verify
R6137 T9275 T9276 advcl verify,analyzed
R6138 T9277 T9278 mark whether,resulted
R6139 T9278 T9275 ccomp resulted,verify
R6140 T9279 T9280 det the,changes
R6141 T9280 T9278 nsubj changes,resulted
R6142 T9281 T9280 compound mRNA,changes
R6143 T9282 T9278 prep in,resulted
R6144 T9283 T9282 pobj alteration,in
R6145 T9284 T9283 prep of,alteration
R6146 T9285 T9286 det the,changes
R6147 T9286 T9284 pobj changes,of
R6148 T9287 T9288 compound enzyme,activity
R6149 T9288 T9286 compound activity,changes
R6150 T9289 T9276 punct ", ",analyzed
R6151 T9290 T9291 compound liver,samples
R6152 T9291 T9276 nsubjpass samples,analyzed
R6153 T9292 T9276 auxpass were,analyzed
R6154 T9293 T9276 prep for,analyzed
R6155 T9294 T9295 compound HMG,CoA
R6156 T9295 T9297 compound CoA,reductase
R6157 T9296 T9295 punct -,CoA
R6158 T9297 T9298 compound reductase,activity
R6159 T9298 T9293 pobj activity,for
R6160 T9299 T9298 cc and,activity
R6161 T9300 T9301 compound Cyp7a1,activity
R6162 T9301 T9298 conj activity,activity
R6163 T9302 T9303 punct (,4b
R6164 T9303 T9276 parataxis 4b,analyzed
R6165 T9304 T9303 compound Figure,4b
R6166 T9305 T9303 punct ),4b
R6167 T9306 T9276 punct .,analyzed
R6168 T9308 T9309 compound HMG,CoA
R6169 T9309 T9311 compound CoA,reductase
R6170 T9310 T9309 punct -,CoA
R6171 T9311 T9312 compound reductase,activity
R6172 T9312 T9313 nsubjpass activity,reduced
R6173 T9314 T9313 auxpass was,reduced
R6174 T9315 T9313 prep by,reduced
R6175 T9316 T9317 nummod 30,%
R6176 T9317 T9315 pobj %,by
R6177 T9318 T9317 cc and,%
R6178 T9319 T9320 nummod 60,%
R6179 T9320 T9317 conj %,%
R6180 T9321 T9313 prep in,reduced
R6181 T9322 T9323 det the,mice
R6182 T9323 T9321 pobj mice,in
R6183 T9324 T9323 nmod Abcg8,mice
R6184 T9325 T9324 punct +,Abcg8
R6185 T9326 T9324 punct /,Abcg8
R6186 T9327 T9324 punct -,Abcg8
R6187 T9328 T9324 cc and,Abcg8
R6188 T9329 T9324 conj Abcg8,Abcg8
R6189 T9330 T9329 punct -,Abcg8
R6190 T9331 T9329 punct /,Abcg8
R6191 T9332 T9329 punct -,Abcg8
R6192 T9333 T9313 punct ", ",reduced
R6193 T9334 T9313 advmod respectively,reduced
R6194 T9335 T9336 punct (,4b
R6195 T9336 T9313 parataxis 4b,reduced
R6196 T9337 T9336 compound Figure,4b
R6197 T9338 T9336 punct ),4b
R6198 T9339 T9313 punct ", ",reduced
R6199 T9340 T9313 cc and,reduced
R6200 T9341 T9342 advmod thus,reflected
R6201 T9342 T9313 conj reflected,reduced
R6202 T9343 T9344 det the,changes
R6203 T9344 T9342 dobj changes,reflected
R6204 T9345 T9344 prep in,changes
R6205 T9346 T9347 compound mRNA,expression
R6206 T9347 T9345 pobj expression,in
R6207 T9348 T9313 punct .,reduced
R6208 T9350 T9351 prep In,decreased
R6209 T9352 T9350 pobj contrast,In
R6210 T9353 T9351 punct ", ",decreased
R6211 T9354 T9355 mark although,were
R6212 T9355 T9351 advcl were,decreased
R6213 T9356 T9357 det the,levels
R6214 T9357 T9355 nsubj levels,were
R6215 T9358 T9359 compound Cyp7a1,mRNA
R6216 T9359 T9357 compound mRNA,levels
R6217 T9360 T9357 compound expression,levels
R6218 T9361 T9362 advmod essentially,unchanged
R6219 T9362 T9355 acomp unchanged,were
R6220 T9363 T9355 prep in,were
R6221 T9364 T9365 det the,mouse
R6222 T9365 T9363 pobj mouse,in
R6223 T9366 T9365 compound knockout,mouse
R6224 T9367 T9351 punct ", ",decreased
R6225 T9368 T9369 compound Cyp7a1,activity
R6226 T9369 T9351 nsubjpass activity,decreased
R6227 T9370 T9351 auxpass was,decreased
R6228 T9371 T9351 advmod significantly,decreased
R6229 T9372 T9351 prep by,decreased
R6230 T9373 T9374 nummod 37,%
R6231 T9374 T9372 pobj %,by
R6232 T9375 T9376 punct (,0.01
R6233 T9376 T9351 parataxis 0.01,decreased
R6234 T9377 T9376 nsubj P,0.01
R6235 T9378 T9376 punct <,0.01
R6236 T9379 T9376 punct ),0.01
R6237 T9380 T9351 punct .,decreased
R6238 T9382 T9383 prep In,decreased
R6239 T9384 T9385 det the,mice
R6240 T9385 T9382 pobj mice,In
R6241 T9386 T9385 amod heterozygous,mice
R6242 T9387 T9383 punct ", ",decreased
R6243 T9388 T9389 preconj both,mRNA
R6244 T9389 T9383 nsubjpass mRNA,decreased
R6245 T9390 T9389 det the,mRNA
R6246 T9391 T9389 cc and,mRNA
R6247 T9392 T9389 conj activity,mRNA
R6248 T9393 T9392 prep of,activity
R6249 T9394 T9393 pobj Cyp7a1,of
R6250 T9395 T9383 auxpass were,decreased
R6251 T9396 T9383 punct .,decreased
R6252 T9398 T9399 nsubjpass Sitosterol,known
R6253 T9400 T9399 auxpass is,known
R6254 T9401 T9402 aux to,be
R6255 T9402 T9399 xcomp be,known
R6256 T9403 T9404 det a,inhibitor
R6257 T9404 T9402 attr inhibitor,be
R6258 T9405 T9404 amod direct,inhibitor
R6259 T9406 T9404 amod competitive,inhibitor
R6260 T9407 T9404 prep of,inhibitor
R6261 T9408 T9407 pobj Cyp7a1,of
R6262 T9409 T9399 cc and,known
R6263 T9410 T9411 nsubj it,is
R6264 T9411 T9399 conj is,known
R6265 T9412 T9411 acomp likely,is
R6266 T9413 T9414 mark that,are
R6267 T9414 T9411 ccomp are,is
R6268 T9415 T9416 det the,sterols
R6269 T9416 T9414 nsubj sterols,are
R6270 T9417 T9416 amod elevated,sterols
R6271 T9418 T9416 compound plant,sterols
R6272 T9419 T9416 prep in,sterols
R6273 T9420 T9421 det the,liver
R6274 T9421 T9419 pobj liver,in
R6275 T9422 T9414 acomp responsible,are
R6276 T9423 T9422 prep for,responsible
R6277 T9424 T9425 det the,inhibition
R6278 T9425 T9423 pobj inhibition,for
R6279 T9426 T9425 prep in,inhibition
R6280 T9427 T9428 det the,mouse
R6281 T9428 T9426 pobj mouse,in
R6282 T9429 T9428 compound knockout,mouse
R6283 T9430 T9431 punct [,39
R6284 T9431 T9411 parataxis 39,is
R6285 T9432 T9431 punct ],39
R6286 T9433 T9411 punct .,is