| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T228 |
0-10 |
sentence |
denotes |
Background |
| T229 |
0-10 |
NN |
denotes |
Background |
| T230 |
10-129 |
sentence |
denotes |
We have recently cloned and characterized a novel gene family named ancient conserved domain protein (ACDP) in humans. |
| T231 |
11-13 |
PRP |
denotes |
We |
| T233 |
14-18 |
VBP |
denotes |
have |
| T234 |
19-27 |
RB |
denotes |
recently |
| T232 |
28-34 |
VBN |
denotes |
cloned |
| T235 |
35-38 |
CC |
denotes |
and |
| T236 |
39-52 |
VBN |
denotes |
characterized |
| T237 |
53-54 |
DT |
denotes |
a |
| T239 |
55-60 |
JJ |
denotes |
novel |
| T240 |
61-65 |
NN |
denotes |
gene |
| T238 |
66-72 |
NN |
denotes |
family |
| T241 |
73-78 |
VBN |
denotes |
named |
| T242 |
79-86 |
JJ |
denotes |
ancient |
| T244 |
87-96 |
VBN |
denotes |
conserved |
| T245 |
97-103 |
NN |
denotes |
domain |
| T243 |
104-111 |
NN |
denotes |
protein |
| T246 |
112-113 |
-LRB- |
denotes |
( |
| T247 |
113-117 |
NN |
denotes |
ACDP |
| T248 |
117-118 |
-RRB- |
denotes |
) |
| T249 |
119-121 |
IN |
denotes |
in |
| T250 |
122-128 |
NNS |
denotes |
humans |
| T251 |
128-129 |
. |
denotes |
. |
| T252 |
129-281 |
sentence |
denotes |
To facilitate the functional study of this novel gene family, we have cloned and characterized Acdp, the mouse homologue of the human ACDP gene family. |
| T253 |
130-132 |
TO |
denotes |
To |
| T254 |
133-143 |
VB |
denotes |
facilitate |
| T256 |
144-147 |
DT |
denotes |
the |
| T258 |
148-158 |
JJ |
denotes |
functional |
| T257 |
159-164 |
NN |
denotes |
study |
| T259 |
165-167 |
IN |
denotes |
of |
| T260 |
168-172 |
DT |
denotes |
this |
| T262 |
173-178 |
JJ |
denotes |
novel |
| T263 |
179-183 |
NN |
denotes |
gene |
| T261 |
184-190 |
NN |
denotes |
family |
| T264 |
190-192 |
, |
denotes |
, |
| T265 |
192-194 |
PRP |
denotes |
we |
| T266 |
195-199 |
VBP |
denotes |
have |
| T255 |
200-206 |
VBN |
denotes |
cloned |
| T267 |
207-210 |
CC |
denotes |
and |
| T268 |
211-224 |
VBN |
denotes |
characterized |
| T269 |
225-229 |
NN |
denotes |
Acdp |
| T270 |
229-231 |
, |
denotes |
, |
| T271 |
231-234 |
DT |
denotes |
the |
| T273 |
235-240 |
NN |
denotes |
mouse |
| T272 |
241-250 |
NN |
denotes |
homologue |
| T274 |
251-253 |
IN |
denotes |
of |
| T275 |
254-257 |
DT |
denotes |
the |
| T277 |
258-263 |
JJ |
denotes |
human |
| T278 |
264-268 |
NN |
denotes |
ACDP |
| T279 |
269-273 |
NN |
denotes |
gene |
| T276 |
274-280 |
NN |
denotes |
family |
| T280 |
280-281 |
. |
denotes |
. |
| T281 |
281-290 |
sentence |
denotes |
Results |
| T282 |
283-290 |
NNS |
denotes |
Results |
| T283 |
290-491 |
sentence |
denotes |
The four Acdp genes (Acdp1, Acdp2, Acdp3 and Acdp4) contain 3,631 bp, 3,244 bp, 2,684 bp and 2,743 bp of cDNA sequences, and encode deduced proteins of 951, 874, 713 and 771 amino acids, respectively. |
| T284 |
291-294 |
DT |
denotes |
The |
| T286 |
295-299 |
CD |
denotes |
four |
| T287 |
300-304 |
NN |
denotes |
Acdp |
| T285 |
305-310 |
NNS |
denotes |
genes |
| T289 |
311-312 |
-LRB- |
denotes |
( |
| T290 |
312-317 |
NN |
denotes |
Acdp1 |
| T291 |
317-319 |
, |
denotes |
, |
| T292 |
319-324 |
NN |
denotes |
Acdp2 |
| T293 |
324-326 |
, |
denotes |
, |
| T294 |
326-331 |
NN |
denotes |
Acdp3 |
| T295 |
332-335 |
CC |
denotes |
and |
| T296 |
336-341 |
NN |
denotes |
Acdp4 |
| T297 |
341-342 |
-RRB- |
denotes |
) |
| T288 |
343-350 |
VBP |
denotes |
contain |
| T298 |
351-356 |
CD |
denotes |
3,631 |
| T299 |
357-359 |
NNS |
denotes |
bp |
| T300 |
359-361 |
, |
denotes |
, |
| T301 |
361-366 |
CD |
denotes |
3,244 |
| T302 |
367-369 |
NNS |
denotes |
bp |
| T303 |
369-371 |
, |
denotes |
, |
| T304 |
371-376 |
CD |
denotes |
2,684 |
| T305 |
377-379 |
NNS |
denotes |
bp |
| T306 |
380-383 |
CC |
denotes |
and |
| T307 |
384-389 |
CD |
denotes |
2,743 |
| T308 |
390-392 |
NNS |
denotes |
bp |
| T309 |
393-395 |
IN |
denotes |
of |
| T310 |
396-400 |
NN |
denotes |
cDNA |
| T311 |
401-410 |
NNS |
denotes |
sequences |
| T312 |
410-412 |
, |
denotes |
, |
| T313 |
412-415 |
CC |
denotes |
and |
| T314 |
416-422 |
VBP |
denotes |
encode |
| T315 |
423-430 |
VBN |
denotes |
deduced |
| T316 |
431-439 |
NN |
denotes |
proteins |
| T317 |
440-442 |
IN |
denotes |
of |
| T318 |
443-446 |
CD |
denotes |
951 |
| T320 |
446-448 |
, |
denotes |
, |
| T321 |
448-451 |
CD |
denotes |
874 |
| T322 |
451-453 |
, |
denotes |
, |
| T323 |
453-456 |
CD |
denotes |
713 |
| T324 |
457-460 |
CC |
denotes |
and |
| T325 |
461-464 |
CD |
denotes |
771 |
| T326 |
465-470 |
NN |
denotes |
amino |
| T319 |
471-476 |
NNS |
denotes |
acids |
| T327 |
476-478 |
, |
denotes |
, |
| T328 |
478-490 |
RB |
denotes |
respectively |
| T329 |
490-491 |
. |
denotes |
. |
| T330 |
491-622 |
sentence |
denotes |
The mouse Acdp genes showed very strong homologies (>90%) in both nucleotide and amino acid sequences to their human counterparts. |
| T331 |
492-495 |
DT |
denotes |
The |
| T333 |
496-501 |
NN |
denotes |
mouse |
| T334 |
502-506 |
NN |
denotes |
Acdp |
| T332 |
507-512 |
NNS |
denotes |
genes |
| T335 |
513-519 |
VBD |
denotes |
showed |
| T336 |
520-524 |
RB |
denotes |
very |
| T337 |
525-531 |
JJ |
denotes |
strong |
| T338 |
532-542 |
NNS |
denotes |
homologies |
| T339 |
543-544 |
-LRB- |
denotes |
( |
| T341 |
544-545 |
SYM |
denotes |
> |
| T342 |
545-547 |
CD |
denotes |
90 |
| T340 |
547-548 |
NN |
denotes |
% |
| T343 |
548-549 |
-RRB- |
denotes |
) |
| T344 |
550-552 |
IN |
denotes |
in |
| T345 |
553-557 |
CC |
denotes |
both |
| T346 |
558-568 |
NN |
denotes |
nucleotide |
| T348 |
569-572 |
CC |
denotes |
and |
| T349 |
573-578 |
NN |
denotes |
amino |
| T350 |
579-583 |
NN |
denotes |
acid |
| T347 |
584-593 |
NNS |
denotes |
sequences |
| T351 |
594-596 |
IN |
denotes |
to |
| T352 |
597-602 |
PRP$ |
denotes |
their |
| T354 |
603-608 |
JJ |
denotes |
human |
| T353 |
609-621 |
NNS |
denotes |
counterparts |
| T355 |
621-622 |
. |
denotes |
. |
| T356 |
622-776 |
sentence |
denotes |
In addition, both nucleotide and amino acid sequences within the Ancient Conserved Domain (ACD) are highly conserved in many different taxonomic species. |
| T357 |
623-625 |
IN |
denotes |
In |
| T359 |
626-634 |
NN |
denotes |
addition |
| T360 |
634-636 |
, |
denotes |
, |
| T361 |
636-640 |
CC |
denotes |
both |
| T362 |
641-651 |
NN |
denotes |
nucleotide |
| T364 |
652-655 |
CC |
denotes |
and |
| T365 |
656-661 |
NN |
denotes |
amino |
| T366 |
662-666 |
NN |
denotes |
acid |
| T363 |
667-676 |
NNS |
denotes |
sequences |
| T367 |
677-683 |
IN |
denotes |
within |
| T368 |
684-687 |
DT |
denotes |
the |
| T370 |
688-695 |
JJ |
denotes |
Ancient |
| T371 |
696-705 |
VBN |
denotes |
Conserved |
| T369 |
706-712 |
NN |
denotes |
Domain |
| T372 |
713-714 |
-LRB- |
denotes |
( |
| T373 |
714-717 |
NN |
denotes |
ACD |
| T374 |
717-718 |
-RRB- |
denotes |
) |
| T375 |
719-722 |
VBP |
denotes |
are |
| T376 |
723-729 |
RB |
denotes |
highly |
| T358 |
730-739 |
VBN |
denotes |
conserved |
| T377 |
740-742 |
IN |
denotes |
in |
| T378 |
743-747 |
JJ |
denotes |
many |
| T380 |
748-757 |
JJ |
denotes |
different |
| T381 |
758-767 |
JJ |
denotes |
taxonomic |
| T379 |
768-775 |
NNS |
denotes |
species |
| T382 |
775-776 |
. |
denotes |
. |
| T383 |
776-953 |
sentence |
denotes |
Particularly, Acdp proteins showed very strong AA homologies to the bacteria CorC protein (35% AA identity with 55% homology), which is involved in magnesium and cobalt efflux. |
| T384 |
777-789 |
RB |
denotes |
Particularly |
| T386 |
789-791 |
, |
denotes |
, |
| T387 |
791-795 |
NN |
denotes |
Acdp |
| T388 |
796-804 |
NN |
denotes |
proteins |
| T385 |
805-811 |
VBD |
denotes |
showed |
| T389 |
812-816 |
RB |
denotes |
very |
| T390 |
817-823 |
JJ |
denotes |
strong |
| T392 |
824-826 |
NN |
denotes |
AA |
| T391 |
827-837 |
NNS |
denotes |
homologies |
| T393 |
838-840 |
IN |
denotes |
to |
| T394 |
841-844 |
DT |
denotes |
the |
| T396 |
845-853 |
NNS |
denotes |
bacteria |
| T397 |
854-858 |
NN |
denotes |
CorC |
| T395 |
859-866 |
NN |
denotes |
protein |
| T398 |
867-868 |
-LRB- |
denotes |
( |
| T400 |
868-870 |
CD |
denotes |
35 |
| T401 |
870-871 |
NN |
denotes |
% |
| T402 |
872-874 |
NN |
denotes |
AA |
| T399 |
875-883 |
NN |
denotes |
identity |
| T403 |
884-888 |
IN |
denotes |
with |
| T404 |
889-891 |
CD |
denotes |
55 |
| T405 |
891-892 |
NN |
denotes |
% |
| T406 |
893-901 |
NN |
denotes |
homology |
| T407 |
901-902 |
-RRB- |
denotes |
) |
| T408 |
902-904 |
, |
denotes |
, |
| T409 |
904-909 |
WDT |
denotes |
which |
| T411 |
910-912 |
VBZ |
denotes |
is |
| T410 |
913-921 |
VBN |
denotes |
involved |
| T412 |
922-924 |
IN |
denotes |
in |
| T413 |
925-934 |
NN |
denotes |
magnesium |
| T415 |
935-938 |
CC |
denotes |
and |
| T416 |
939-945 |
NN |
denotes |
cobalt |
| T414 |
946-952 |
NN |
denotes |
efflux |
| T417 |
952-953 |
. |
denotes |
. |
| T418 |
953-1125 |
sentence |
denotes |
The Acdp genes are widely expressed in all tissues tested except for Acdp1, which is only highly expressed in the brain with low levels of expression in kidney and testis. |
| T419 |
954-957 |
DT |
denotes |
The |
| T421 |
958-962 |
NN |
denotes |
Acdp |
| T420 |
963-968 |
NNS |
denotes |
genes |
| T423 |
969-972 |
VBP |
denotes |
are |
| T424 |
973-979 |
RB |
denotes |
widely |
| T422 |
980-989 |
VBN |
denotes |
expressed |
| T425 |
990-992 |
IN |
denotes |
in |
| T426 |
993-996 |
DT |
denotes |
all |
| T427 |
997-1004 |
NNS |
denotes |
tissues |
| T428 |
1005-1011 |
VBN |
denotes |
tested |
| T429 |
1012-1018 |
IN |
denotes |
except |
| T430 |
1019-1022 |
IN |
denotes |
for |
| T431 |
1023-1028 |
NN |
denotes |
Acdp1 |
| T432 |
1028-1030 |
, |
denotes |
, |
| T433 |
1030-1035 |
WDT |
denotes |
which |
| T435 |
1036-1038 |
VBZ |
denotes |
is |
| T436 |
1039-1043 |
RB |
denotes |
only |
| T437 |
1044-1050 |
RB |
denotes |
highly |
| T434 |
1051-1060 |
VBN |
denotes |
expressed |
| T438 |
1061-1063 |
IN |
denotes |
in |
| T439 |
1064-1067 |
DT |
denotes |
the |
| T440 |
1068-1073 |
NN |
denotes |
brain |
| T441 |
1074-1078 |
IN |
denotes |
with |
| T443 |
1079-1082 |
JJ |
denotes |
low |
| T442 |
1083-1089 |
NNS |
denotes |
levels |
| T444 |
1090-1092 |
IN |
denotes |
of |
| T445 |
1093-1103 |
NN |
denotes |
expression |
| T446 |
1104-1106 |
IN |
denotes |
in |
| T447 |
1107-1113 |
NN |
denotes |
kidney |
| T448 |
1114-1117 |
CC |
denotes |
and |
| T449 |
1118-1124 |
NN |
denotes |
testis |
| T450 |
1124-1125 |
. |
denotes |
. |
| T451 |
1125-1232 |
sentence |
denotes |
Immunostaining of Acdp1 in hippocampus neurons revealed a predominant localization on the plasma membrane. |
| T452 |
1126-1140 |
NN |
denotes |
Immunostaining |
| T454 |
1141-1143 |
IN |
denotes |
of |
| T455 |
1144-1149 |
NN |
denotes |
Acdp1 |
| T456 |
1150-1152 |
IN |
denotes |
in |
| T457 |
1153-1164 |
NN |
denotes |
hippocampus |
| T458 |
1165-1172 |
NNS |
denotes |
neurons |
| T453 |
1173-1181 |
VBD |
denotes |
revealed |
| T459 |
1182-1183 |
DT |
denotes |
a |
| T461 |
1184-1195 |
JJ |
denotes |
predominant |
| T460 |
1196-1208 |
NN |
denotes |
localization |
| T462 |
1209-1211 |
IN |
denotes |
on |
| T463 |
1212-1215 |
DT |
denotes |
the |
| T465 |
1216-1222 |
NN |
denotes |
plasma |
| T464 |
1223-1231 |
NN |
denotes |
membrane |
| T466 |
1231-1232 |
. |
denotes |
. |
| T467 |
1232-1244 |
sentence |
denotes |
Conclusion |
| T468 |
1234-1244 |
NN |
denotes |
Conclusion |
| T469 |
1244-1422 |
sentence |
denotes |
The Acdp genes are evolutionarily conserved in diverse species and ubiquitously expressed throughout development and adult tissues suggesting that Acdp may be an essential gene. |
| T470 |
1245-1248 |
DT |
denotes |
The |
| T472 |
1249-1253 |
NN |
denotes |
Acdp |
| T471 |
1254-1259 |
NNS |
denotes |
genes |
| T474 |
1260-1263 |
VBP |
denotes |
are |
| T475 |
1264-1278 |
RB |
denotes |
evolutionarily |
| T473 |
1279-1288 |
VBN |
denotes |
conserved |
| T476 |
1289-1291 |
IN |
denotes |
in |
| T477 |
1292-1299 |
JJ |
denotes |
diverse |
| T478 |
1300-1307 |
NNS |
denotes |
species |
| T479 |
1308-1311 |
CC |
denotes |
and |
| T480 |
1312-1324 |
RB |
denotes |
ubiquitously |
| T481 |
1325-1334 |
VBN |
denotes |
expressed |
| T482 |
1335-1345 |
IN |
denotes |
throughout |
| T483 |
1346-1357 |
NN |
denotes |
development |
| T484 |
1358-1361 |
CC |
denotes |
and |
| T485 |
1362-1367 |
JJ |
denotes |
adult |
| T486 |
1368-1375 |
NNS |
denotes |
tissues |
| T487 |
1376-1386 |
VBG |
denotes |
suggesting |
| T488 |
1387-1391 |
IN |
denotes |
that |
| T490 |
1392-1396 |
NN |
denotes |
Acdp |
| T491 |
1397-1400 |
MD |
denotes |
may |
| T489 |
1401-1403 |
VB |
denotes |
be |
| T492 |
1404-1406 |
DT |
denotes |
an |
| T494 |
1407-1416 |
JJ |
denotes |
essential |
| T493 |
1417-1421 |
NN |
denotes |
gene |
| T495 |
1421-1422 |
. |
denotes |
. |
| T496 |
1422-1527 |
sentence |
denotes |
Acdp showed strong homology to bacteria CorC protein and predominantly localized on the plasma membrane. |
| T497 |
1423-1427 |
NN |
denotes |
Acdp |
| T498 |
1428-1434 |
VBD |
denotes |
showed |
| T499 |
1435-1441 |
JJ |
denotes |
strong |
| T500 |
1442-1450 |
NN |
denotes |
homology |
| T501 |
1451-1453 |
IN |
denotes |
to |
| T502 |
1454-1462 |
NNS |
denotes |
bacteria |
| T504 |
1463-1467 |
NN |
denotes |
CorC |
| T503 |
1468-1475 |
NN |
denotes |
protein |
| T505 |
1476-1479 |
CC |
denotes |
and |
| T506 |
1480-1493 |
RB |
denotes |
predominantly |
| T507 |
1494-1503 |
VBD |
denotes |
localized |
| T508 |
1504-1506 |
IN |
denotes |
on |
| T509 |
1507-1510 |
DT |
denotes |
the |
| T511 |
1511-1517 |
NN |
denotes |
plasma |
| T510 |
1518-1526 |
NN |
denotes |
membrane |
| T512 |
1526-1527 |
. |
denotes |
. |
| T513 |
1527-1637 |
sentence |
denotes |
These results suggest that Acdp is probably a family of proteins involved in ion transport in mammalian cells |
| T514 |
1528-1533 |
DT |
denotes |
These |
| T515 |
1534-1541 |
NNS |
denotes |
results |
| T516 |
1542-1549 |
VBP |
denotes |
suggest |
| T517 |
1550-1554 |
IN |
denotes |
that |
| T519 |
1555-1559 |
NN |
denotes |
Acdp |
| T518 |
1560-1562 |
VBZ |
denotes |
is |
| T520 |
1563-1571 |
RB |
denotes |
probably |
| T521 |
1572-1573 |
DT |
denotes |
a |
| T522 |
1574-1580 |
NN |
denotes |
family |
| T523 |
1581-1583 |
IN |
denotes |
of |
| T524 |
1584-1592 |
NN |
denotes |
proteins |
| T525 |
1593-1601 |
VBN |
denotes |
involved |
| T526 |
1602-1604 |
IN |
denotes |
in |
| T527 |
1605-1608 |
NN |
denotes |
ion |
| T528 |
1609-1618 |
NN |
denotes |
transport |
| T529 |
1619-1621 |
IN |
denotes |
in |
| T530 |
1622-1631 |
JJ |
denotes |
mammalian |
| T531 |
1632-1637 |
NNS |
denotes |
cells |
| R100 |
T327 |
T314 |
punct |
", ",encode |
| R101 |
T328 |
T314 |
advmod |
respectively,encode |
| R102 |
T329 |
T288 |
punct |
.,contain |
| R103 |
T331 |
T332 |
det |
The,genes |
| R104 |
T332 |
T335 |
nsubj |
genes,showed |
| R105 |
T333 |
T332 |
compound |
mouse,genes |
| R106 |
T334 |
T332 |
compound |
Acdp,genes |
| R107 |
T336 |
T337 |
advmod |
very,strong |
| R108 |
T337 |
T338 |
amod |
strong,homologies |
| R109 |
T338 |
T335 |
dobj |
homologies,showed |
| R11 |
T231 |
T232 |
nsubj |
We,cloned |
| R110 |
T339 |
T340 |
punct |
(,% |
| R111 |
T340 |
T338 |
parataxis |
%,homologies |
| R112 |
T341 |
T342 |
punct |
>,90 |
| R113 |
T342 |
T340 |
nummod |
90,% |
| R114 |
T343 |
T340 |
punct |
),% |
| R115 |
T344 |
T338 |
prep |
in,homologies |
| R116 |
T345 |
T346 |
preconj |
both,nucleotide |
| R117 |
T346 |
T347 |
nmod |
nucleotide,sequences |
| R118 |
T347 |
T344 |
pobj |
sequences,in |
| R119 |
T348 |
T346 |
cc |
and,nucleotide |
| R12 |
T233 |
T232 |
aux |
have,cloned |
| R120 |
T349 |
T350 |
compound |
amino,acid |
| R121 |
T350 |
T346 |
conj |
acid,nucleotide |
| R122 |
T351 |
T338 |
prep |
to,homologies |
| R123 |
T352 |
T353 |
poss |
their,counterparts |
| R124 |
T353 |
T351 |
pobj |
counterparts,to |
| R125 |
T354 |
T353 |
amod |
human,counterparts |
| R126 |
T355 |
T335 |
punct |
.,showed |
| R127 |
T357 |
T358 |
prep |
In,conserved |
| R128 |
T359 |
T357 |
pobj |
addition,In |
| R129 |
T360 |
T358 |
punct |
", ",conserved |
| R13 |
T234 |
T232 |
advmod |
recently,cloned |
| R130 |
T361 |
T362 |
preconj |
both,nucleotide |
| R131 |
T362 |
T363 |
nmod |
nucleotide,sequences |
| R132 |
T363 |
T358 |
nsubjpass |
sequences,conserved |
| R133 |
T364 |
T362 |
cc |
and,nucleotide |
| R134 |
T365 |
T366 |
compound |
amino,acid |
| R135 |
T366 |
T362 |
conj |
acid,nucleotide |
| R136 |
T367 |
T363 |
prep |
within,sequences |
| R137 |
T368 |
T369 |
det |
the,Domain |
| R138 |
T369 |
T367 |
pobj |
Domain,within |
| R139 |
T370 |
T369 |
amod |
Ancient,Domain |
| R14 |
T235 |
T232 |
cc |
and,cloned |
| R140 |
T371 |
T369 |
amod |
Conserved,Domain |
| R141 |
T372 |
T369 |
punct |
(,Domain |
| R142 |
T373 |
T369 |
appos |
ACD,Domain |
| R143 |
T374 |
T358 |
punct |
),conserved |
| R144 |
T375 |
T358 |
auxpass |
are,conserved |
| R145 |
T376 |
T358 |
advmod |
highly,conserved |
| R146 |
T377 |
T358 |
prep |
in,conserved |
| R147 |
T378 |
T379 |
amod |
many,species |
| R148 |
T379 |
T377 |
pobj |
species,in |
| R149 |
T380 |
T379 |
amod |
different,species |
| R15 |
T236 |
T232 |
conj |
characterized,cloned |
| R150 |
T381 |
T379 |
amod |
taxonomic,species |
| R151 |
T382 |
T358 |
punct |
.,conserved |
| R152 |
T384 |
T385 |
advmod |
Particularly,showed |
| R153 |
T386 |
T385 |
punct |
", ",showed |
| R154 |
T387 |
T388 |
compound |
Acdp,proteins |
| R155 |
T388 |
T385 |
nsubj |
proteins,showed |
| R156 |
T389 |
T390 |
advmod |
very,strong |
| R157 |
T390 |
T391 |
amod |
strong,homologies |
| R158 |
T391 |
T385 |
dobj |
homologies,showed |
| R159 |
T392 |
T391 |
compound |
AA,homologies |
| R16 |
T237 |
T238 |
det |
a,family |
| R160 |
T393 |
T391 |
prep |
to,homologies |
| R161 |
T394 |
T395 |
det |
the,protein |
| R162 |
T395 |
T393 |
pobj |
protein,to |
| R163 |
T396 |
T395 |
compound |
bacteria,protein |
| R164 |
T397 |
T395 |
compound |
CorC,protein |
| R165 |
T398 |
T399 |
punct |
(,identity |
| R166 |
T399 |
T395 |
parataxis |
identity,protein |
| R167 |
T400 |
T401 |
nummod |
35,% |
| R168 |
T401 |
T399 |
compound |
%,identity |
| R169 |
T402 |
T399 |
compound |
AA,identity |
| R17 |
T238 |
T236 |
dobj |
family,characterized |
| R170 |
T403 |
T399 |
prep |
with,identity |
| R171 |
T404 |
T405 |
nummod |
55,% |
| R172 |
T405 |
T406 |
compound |
%,homology |
| R173 |
T406 |
T403 |
pobj |
homology,with |
| R174 |
T407 |
T399 |
punct |
),identity |
| R175 |
T408 |
T395 |
punct |
", ",protein |
| R176 |
T409 |
T410 |
dep |
which,involved |
| R177 |
T410 |
T395 |
relcl |
involved,protein |
| R178 |
T411 |
T410 |
auxpass |
is,involved |
| R179 |
T412 |
T410 |
prep |
in,involved |
| R18 |
T239 |
T238 |
amod |
novel,family |
| R180 |
T413 |
T414 |
nmod |
magnesium,efflux |
| R181 |
T414 |
T412 |
pobj |
efflux,in |
| R182 |
T415 |
T413 |
cc |
and,magnesium |
| R183 |
T416 |
T413 |
conj |
cobalt,magnesium |
| R184 |
T417 |
T385 |
punct |
.,showed |
| R185 |
T419 |
T420 |
det |
The,genes |
| R186 |
T420 |
T422 |
nsubjpass |
genes,expressed |
| R187 |
T421 |
T420 |
compound |
Acdp,genes |
| R188 |
T423 |
T422 |
auxpass |
are,expressed |
| R189 |
T424 |
T422 |
advmod |
widely,expressed |
| R19 |
T240 |
T238 |
compound |
gene,family |
| R190 |
T425 |
T422 |
prep |
in,expressed |
| R191 |
T426 |
T427 |
det |
all,tissues |
| R192 |
T427 |
T425 |
pobj |
tissues,in |
| R193 |
T428 |
T427 |
acl |
tested,tissues |
| R194 |
T429 |
T422 |
prep |
except,expressed |
| R195 |
T430 |
T429 |
prep |
for,except |
| R196 |
T431 |
T430 |
pobj |
Acdp1,for |
| R197 |
T432 |
T431 |
punct |
", ",Acdp1 |
| R198 |
T433 |
T434 |
dep |
which,expressed |
| R199 |
T434 |
T431 |
relcl |
expressed,Acdp1 |
| R20 |
T241 |
T238 |
acl |
named,family |
| R200 |
T435 |
T434 |
auxpass |
is,expressed |
| R201 |
T436 |
T434 |
advmod |
only,expressed |
| R202 |
T437 |
T434 |
advmod |
highly,expressed |
| R203 |
T438 |
T434 |
prep |
in,expressed |
| R204 |
T439 |
T440 |
det |
the,brain |
| R205 |
T440 |
T438 |
pobj |
brain,in |
| R206 |
T441 |
T442 |
mark |
with,levels |
| R207 |
T442 |
T434 |
advcl |
levels,expressed |
| R208 |
T443 |
T442 |
amod |
low,levels |
| R209 |
T444 |
T442 |
prep |
of,levels |
| R21 |
T242 |
T243 |
amod |
ancient,protein |
| R210 |
T445 |
T444 |
pobj |
expression,of |
| R211 |
T446 |
T442 |
prep |
in,levels |
| R212 |
T447 |
T446 |
pobj |
kidney,in |
| R213 |
T448 |
T447 |
cc |
and,kidney |
| R214 |
T449 |
T447 |
conj |
testis,kidney |
| R215 |
T450 |
T422 |
punct |
.,expressed |
| R216 |
T452 |
T453 |
nsubj |
Immunostaining,revealed |
| R217 |
T454 |
T452 |
prep |
of,Immunostaining |
| R218 |
T455 |
T454 |
pobj |
Acdp1,of |
| R219 |
T456 |
T455 |
prep |
in,Acdp1 |
| R22 |
T243 |
T241 |
oprd |
protein,named |
| R220 |
T457 |
T458 |
compound |
hippocampus,neurons |
| R221 |
T458 |
T456 |
pobj |
neurons,in |
| R222 |
T459 |
T460 |
det |
a,localization |
| R223 |
T460 |
T453 |
dobj |
localization,revealed |
| R224 |
T461 |
T460 |
amod |
predominant,localization |
| R225 |
T462 |
T453 |
prep |
on,revealed |
| R226 |
T463 |
T464 |
det |
the,membrane |
| R227 |
T464 |
T462 |
pobj |
membrane,on |
| R228 |
T465 |
T464 |
compound |
plasma,membrane |
| R229 |
T466 |
T453 |
punct |
.,revealed |
| R23 |
T244 |
T243 |
amod |
conserved,protein |
| R230 |
T470 |
T471 |
det |
The,genes |
| R231 |
T471 |
T473 |
nsubjpass |
genes,conserved |
| R232 |
T472 |
T471 |
compound |
Acdp,genes |
| R233 |
T474 |
T473 |
auxpass |
are,conserved |
| R234 |
T475 |
T473 |
advmod |
evolutionarily,conserved |
| R235 |
T476 |
T473 |
prep |
in,conserved |
| R236 |
T477 |
T478 |
amod |
diverse,species |
| R237 |
T478 |
T476 |
pobj |
species,in |
| R238 |
T479 |
T473 |
cc |
and,conserved |
| R239 |
T480 |
T481 |
advmod |
ubiquitously,expressed |
| R24 |
T245 |
T243 |
compound |
domain,protein |
| R240 |
T481 |
T473 |
conj |
expressed,conserved |
| R241 |
T482 |
T481 |
prep |
throughout,expressed |
| R242 |
T483 |
T482 |
pobj |
development,throughout |
| R243 |
T484 |
T483 |
cc |
and,development |
| R244 |
T485 |
T486 |
amod |
adult,tissues |
| R245 |
T486 |
T483 |
conj |
tissues,development |
| R246 |
T487 |
T473 |
advcl |
suggesting,conserved |
| R247 |
T488 |
T489 |
mark |
that,be |
| R248 |
T489 |
T487 |
ccomp |
be,suggesting |
| R249 |
T490 |
T489 |
nsubj |
Acdp,be |
| R25 |
T246 |
T243 |
punct |
(,protein |
| R250 |
T491 |
T489 |
aux |
may,be |
| R251 |
T492 |
T493 |
det |
an,gene |
| R252 |
T493 |
T489 |
attr |
gene,be |
| R253 |
T494 |
T493 |
amod |
essential,gene |
| R254 |
T495 |
T473 |
punct |
.,conserved |
| R255 |
T497 |
T498 |
nsubj |
Acdp,showed |
| R256 |
T499 |
T500 |
amod |
strong,homology |
| R257 |
T500 |
T498 |
dobj |
homology,showed |
| R258 |
T501 |
T498 |
prep |
to,showed |
| R259 |
T502 |
T503 |
compound |
bacteria,protein |
| R26 |
T247 |
T243 |
appos |
ACDP,protein |
| R260 |
T503 |
T501 |
pobj |
protein,to |
| R261 |
T504 |
T503 |
compound |
CorC,protein |
| R262 |
T505 |
T498 |
cc |
and,showed |
| R263 |
T506 |
T507 |
advmod |
predominantly,localized |
| R264 |
T507 |
T498 |
conj |
localized,showed |
| R265 |
T508 |
T507 |
prep |
on,localized |
| R266 |
T509 |
T510 |
det |
the,membrane |
| R267 |
T510 |
T508 |
pobj |
membrane,on |
| R268 |
T511 |
T510 |
compound |
plasma,membrane |
| R269 |
T512 |
T498 |
punct |
.,showed |
| R27 |
T248 |
T241 |
punct |
),named |
| R270 |
T514 |
T515 |
det |
These,results |
| R271 |
T515 |
T516 |
nsubj |
results,suggest |
| R272 |
T517 |
T518 |
mark |
that,is |
| R273 |
T518 |
T516 |
ccomp |
is,suggest |
| R274 |
T519 |
T518 |
nsubj |
Acdp,is |
| R275 |
T520 |
T518 |
advmod |
probably,is |
| R276 |
T521 |
T522 |
det |
a,family |
| R277 |
T522 |
T518 |
attr |
family,is |
| R278 |
T523 |
T522 |
prep |
of,family |
| R279 |
T524 |
T523 |
pobj |
proteins,of |
| R28 |
T249 |
T236 |
prep |
in,characterized |
| R280 |
T525 |
T524 |
acl |
involved,proteins |
| R281 |
T526 |
T525 |
prep |
in,involved |
| R282 |
T527 |
T528 |
compound |
ion,transport |
| R283 |
T528 |
T526 |
pobj |
transport,in |
| R284 |
T529 |
T525 |
prep |
in,involved |
| R285 |
T530 |
T531 |
amod |
mammalian,cells |
| R286 |
T531 |
T529 |
pobj |
cells,in |
| R29 |
T250 |
T249 |
pobj |
humans,in |
| R30 |
T251 |
T232 |
punct |
.,cloned |
| R31 |
T253 |
T254 |
aux |
To,facilitate |
| R32 |
T254 |
T255 |
advcl |
facilitate,cloned |
| R33 |
T256 |
T257 |
det |
the,study |
| R34 |
T257 |
T254 |
dobj |
study,facilitate |
| R35 |
T258 |
T257 |
amod |
functional,study |
| R36 |
T259 |
T257 |
prep |
of,study |
| R37 |
T260 |
T261 |
det |
this,family |
| R38 |
T261 |
T259 |
pobj |
family,of |
| R39 |
T262 |
T261 |
amod |
novel,family |
| R40 |
T263 |
T261 |
compound |
gene,family |
| R41 |
T264 |
T255 |
punct |
", ",cloned |
| R42 |
T265 |
T255 |
nsubj |
we,cloned |
| R43 |
T266 |
T255 |
aux |
have,cloned |
| R44 |
T267 |
T255 |
cc |
and,cloned |
| R45 |
T268 |
T255 |
conj |
characterized,cloned |
| R46 |
T269 |
T268 |
dobj |
Acdp,characterized |
| R47 |
T270 |
T269 |
punct |
", ",Acdp |
| R48 |
T271 |
T272 |
det |
the,homologue |
| R49 |
T272 |
T269 |
appos |
homologue,Acdp |
| R50 |
T273 |
T272 |
compound |
mouse,homologue |
| R51 |
T274 |
T272 |
prep |
of,homologue |
| R52 |
T275 |
T276 |
det |
the,family |
| R53 |
T276 |
T274 |
pobj |
family,of |
| R54 |
T277 |
T276 |
amod |
human,family |
| R55 |
T278 |
T276 |
compound |
ACDP,family |
| R56 |
T279 |
T276 |
compound |
gene,family |
| R57 |
T280 |
T255 |
punct |
.,cloned |
| R58 |
T284 |
T285 |
det |
The,genes |
| R59 |
T285 |
T288 |
nsubj |
genes,contain |
| R60 |
T286 |
T285 |
nummod |
four,genes |
| R61 |
T287 |
T285 |
compound |
Acdp,genes |
| R62 |
T289 |
T285 |
punct |
(,genes |
| R63 |
T290 |
T285 |
appos |
Acdp1,genes |
| R64 |
T291 |
T290 |
punct |
", ",Acdp1 |
| R65 |
T292 |
T290 |
conj |
Acdp2,Acdp1 |
| R66 |
T293 |
T292 |
punct |
", ",Acdp2 |
| R67 |
T294 |
T292 |
conj |
Acdp3,Acdp2 |
| R68 |
T295 |
T294 |
cc |
and,Acdp3 |
| R69 |
T296 |
T294 |
conj |
Acdp4,Acdp3 |
| R70 |
T297 |
T288 |
punct |
),contain |
| R71 |
T298 |
T299 |
nummod |
"3,631",bp |
| R72 |
T299 |
T288 |
dobj |
bp,contain |
| R73 |
T300 |
T299 |
punct |
", ",bp |
| R74 |
T301 |
T302 |
nummod |
"3,244",bp |
| R75 |
T302 |
T299 |
conj |
bp,bp |
| R76 |
T303 |
T302 |
punct |
", ",bp |
| R77 |
T304 |
T305 |
nummod |
"2,684",bp |
| R78 |
T305 |
T302 |
conj |
bp,bp |
| R79 |
T306 |
T305 |
cc |
and,bp |
| R80 |
T307 |
T308 |
nummod |
"2,743",bp |
| R81 |
T308 |
T305 |
conj |
bp,bp |
| R82 |
T309 |
T299 |
prep |
of,bp |
| R83 |
T310 |
T311 |
compound |
cDNA,sequences |
| R84 |
T311 |
T309 |
pobj |
sequences,of |
| R85 |
T312 |
T288 |
punct |
", ",contain |
| R86 |
T313 |
T288 |
cc |
and,contain |
| R87 |
T314 |
T288 |
conj |
encode,contain |
| R88 |
T315 |
T316 |
amod |
deduced,proteins |
| R89 |
T316 |
T314 |
dobj |
proteins,encode |
| R90 |
T317 |
T316 |
prep |
of,proteins |
| R91 |
T318 |
T319 |
nummod |
951,acids |
| R92 |
T319 |
T317 |
pobj |
acids,of |
| R93 |
T320 |
T318 |
punct |
", ",951 |
| R94 |
T321 |
T318 |
conj |
874,951 |
| R95 |
T322 |
T321 |
punct |
", ",874 |
| R96 |
T323 |
T321 |
conj |
713,874 |
| R97 |
T324 |
T323 |
cc |
and,713 |
| R98 |
T325 |
T323 |
conj |
771,713 |
| R99 |
T326 |
T319 |
compound |
amino,acids |
