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PMC:340383 / 16611-17880 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T4051 12-15 PRP$ denotes Our
T4053 16-24 JJ denotes previous
T4052 25-29 NN denotes work
T4055 30-33 VBZ denotes has
T4054 34-43 VBN denotes described
T4056 44-49 JJ denotes human
T4058 50-54 NN denotes ACDP
T4057 55-60 NNS denotes genes
T4059 61-62 -LRB- denotes [
T4060 62-63 CD denotes 1
T4061 63-64 -RRB- denotes ]
T4062 64-65 . denotes .
T4063 65-333 sentence denotes The new information of the current work includes: 1). It is the first time to report the existence of multiple Acdp genes in other mammals in addition to human, while Acdp appears to be a single copy gene in lower organisms such as in C. elegans, yeasts and bacteria.
T4064 66-69 DT denotes The
T4066 70-73 JJ denotes new
T4065 74-85 NN denotes information
T4068 86-88 IN denotes of
T4069 89-92 DT denotes the
T4071 93-100 JJ denotes current
T4070 101-105 NN denotes work
T4067 106-114 VBZ denotes includes
T4073 114-116 : denotes :
T4074 116-117 LS denotes 1
T4075 117-118 -RRB- denotes )
T4076 118-119 , denotes .
T4077 120-122 PRP denotes It
T4072 123-125 VBZ denotes is
T4078 126-129 DT denotes the
T4080 130-135 JJ denotes first
T4079 136-140 NN denotes time
T4081 141-143 TO denotes to
T4082 144-150 VB denotes report
T4083 151-154 DT denotes the
T4084 155-164 NN denotes existence
T4085 165-167 IN denotes of
T4086 168-176 JJ denotes multiple
T4088 177-181 NN denotes Acdp
T4087 182-187 NNS denotes genes
T4089 188-190 IN denotes in
T4090 191-196 JJ denotes other
T4091 197-204 NNS denotes mammals
T4092 205-207 IN denotes in
T4093 208-216 NN denotes addition
T4094 217-219 IN denotes to
T4095 220-225 NN denotes human
T4096 225-227 , denotes ,
T4097 227-232 IN denotes while
T4099 233-237 NN denotes Acdp
T4098 238-245 VBZ denotes appears
T4100 246-248 TO denotes to
T4101 249-251 VB denotes be
T4102 252-253 DT denotes a
T4104 254-260 JJ denotes single
T4105 261-265 NN denotes copy
T4103 266-270 NN denotes gene
T4106 271-273 IN denotes in
T4107 274-279 JJR denotes lower
T4108 280-289 NNS denotes organisms
T4109 290-294 JJ denotes such
T4110 295-297 IN denotes as
T4111 298-300 IN denotes in
T4112 301-303 NNP denotes C.
T4113 304-311 NNP denotes elegans
T4114 311-313 , denotes ,
T4115 313-319 NNS denotes yeasts
T4116 320-323 CC denotes and
T4117 324-332 NNS denotes bacteria
T4118 332-333 . denotes .
T4119 333-961 sentence denotes We have also suggested the evolutionary relationships of Acdp genes in different species (phylogenetic tree); 2). Molecular cloning and characterization of murine Acdp gene family are essential for study of this novel gene family in animal model, e.g. for generation of knockout or transgenic models; 3). We have demonstrated both DNA and amino acid conservations between mouse and human for each Acdp gene and the whole Acdp gene family, which provide important information for the possibility of functional redundancy or overlap between Acdp members; 4). We have generated antibodies specific for Acdp1 and all Acdp proteins.
T4120 334-336 PRP denotes We
T4122 337-341 VBP denotes have
T4123 342-346 RB denotes also
T4121 347-356 VBN denotes suggested
T4125 357-360 DT denotes the
T4127 361-373 JJ denotes evolutionary
T4126 374-387 NNS denotes relationships
T4128 388-390 IN denotes of
T4129 391-395 NN denotes Acdp
T4130 396-401 NNS denotes genes
T4131 402-404 IN denotes in
T4132 405-414 JJ denotes different
T4133 415-422 NNS denotes species
T4134 423-424 -LRB- denotes (
T4136 424-436 JJ denotes phylogenetic
T4135 437-441 NN denotes tree
T4137 441-442 -RRB- denotes )
T4138 442-443 : denotes ;
T4139 444-445 LS denotes 2
T4141 445-446 -RRB- denotes )
T4142 446-447 , denotes .
T4143 448-457 JJ denotes Molecular
T4144 458-465 NN denotes cloning
T4145 466-469 CC denotes and
T4146 470-486 NN denotes characterization
T4147 487-489 IN denotes of
T4148 490-496 JJ denotes murine
T4150 497-501 NN denotes Acdp
T4151 502-506 NN denotes gene
T4149 507-513 NN denotes family
T4140 514-517 VBP denotes are
T4152 518-527 JJ denotes essential
T4153 528-531 IN denotes for
T4154 532-537 NN denotes study
T4155 538-540 IN denotes of
T4156 541-545 DT denotes this
T4158 546-551 JJ denotes novel
T4159 552-556 NN denotes gene
T4157 557-563 NN denotes family
T4160 564-566 IN denotes in
T4161 567-573 NN denotes animal
T4162 574-579 NN denotes model
T4163 579-581 , denotes ,
T4164 581-585 FW denotes e.g.
T4165 586-589 IN denotes for
T4166 590-600 NN denotes generation
T4167 601-603 IN denotes of
T4168 604-612 NN denotes knockout
T4170 613-615 CC denotes or
T4171 616-626 JJ denotes transgenic
T4169 627-633 NNS denotes models
T4172 633-634 : denotes ;
T4173 635-636 LS denotes 3
T4175 636-637 -RRB- denotes )
T4176 637-638 , denotes .
T4177 639-641 PRP denotes We
T4178 642-646 VBP denotes have
T4174 647-659 VBN denotes demonstrated
T4179 660-664 CC denotes both
T4180 665-668 NN denotes DNA
T4182 669-672 CC denotes and
T4183 673-678 NN denotes amino
T4184 679-683 NN denotes acid
T4181 684-697 NNS denotes conservations
T4185 698-705 IN denotes between
T4186 706-711 NN denotes mouse
T4187 712-715 CC denotes and
T4188 716-721 NN denotes human
T4189 722-725 IN denotes for
T4190 726-730 DT denotes each
T4192 731-735 NN denotes Acdp
T4191 736-740 NN denotes gene
T4193 741-744 CC denotes and
T4194 745-748 DT denotes the
T4196 749-754 JJ denotes whole
T4197 755-759 NN denotes Acdp
T4198 760-764 NN denotes gene
T4195 765-771 NN denotes family
T4199 771-773 , denotes ,
T4200 773-778 WDT denotes which
T4201 779-786 VBP denotes provide
T4202 787-796 JJ denotes important
T4203 797-808 NN denotes information
T4204 809-812 IN denotes for
T4205 813-816 DT denotes the
T4206 817-828 NN denotes possibility
T4207 829-831 IN denotes of
T4208 832-842 JJ denotes functional
T4209 843-853 NN denotes redundancy
T4210 854-856 CC denotes or
T4211 857-864 NN denotes overlap
T4212 865-872 IN denotes between
T4213 873-877 NN denotes Acdp
T4214 878-885 NNS denotes members
T4215 885-886 : denotes ;
T4216 887-888 LS denotes 4
T4217 888-889 -RRB- denotes )
T4218 889-890 , denotes .
T4219 891-893 PRP denotes We
T4220 894-898 VBP denotes have
T4124 899-908 VBN denotes generated
T4221 909-919 NNS denotes antibodies
T4222 920-928 JJ denotes specific
T4223 929-932 IN denotes for
T4224 933-938 NN denotes Acdp1
T4225 939-942 CC denotes and
T4226 943-946 DT denotes all
T4228 947-951 NN denotes Acdp
T4227 952-960 NN denotes proteins
T4229 960-961 . denotes .
T4230 961-1032 sentence denotes The Acdp1 C-terminus antibody appears to specifically recognize Acdp1.
T4231 962-965 DT denotes The
T4233 966-971 NN denotes Acdp1
T4234 972-973 NN denotes C
T4236 973-974 HYPH denotes -
T4235 974-982 NN denotes terminus
T4232 983-991 NN denotes antibody
T4237 992-999 VBZ denotes appears
T4238 1000-1002 TO denotes to
T4240 1003-1015 RB denotes specifically
T4239 1016-1025 VB denotes recognize
T4241 1026-1031 NN denotes Acdp1
T4242 1031-1032 . denotes .
T4243 1032-1159 sentence denotes Using this antibody, we have demonstrated that Acdp1 is predominantly localized on the plasma membrane in hippocampus neurons.
T4244 1033-1038 VBG denotes Using
T4246 1039-1043 DT denotes this
T4247 1044-1052 NN denotes antibody
T4248 1052-1054 , denotes ,
T4249 1054-1056 PRP denotes we
T4250 1057-1061 VBP denotes have
T4245 1062-1074 VBN denotes demonstrated
T4251 1075-1079 IN denotes that
T4253 1080-1085 NN denotes Acdp1
T4254 1086-1088 VBZ denotes is
T4255 1089-1102 RB denotes predominantly
T4252 1103-1112 VBN denotes localized
T4256 1113-1115 IN denotes on
T4257 1116-1119 DT denotes the
T4259 1120-1126 NN denotes plasma
T4258 1127-1135 NN denotes membrane
T4260 1136-1138 IN denotes in
T4261 1139-1150 NN denotes hippocampus
T4262 1151-1158 NNS denotes neurons
T4263 1158-1159 . denotes .
T4264 1159-1269 sentence denotes These results represent an important step towards the characterization of functions for the Acdp gene family.
T4265 1160-1165 DT denotes These
T4266 1166-1173 NNS denotes results
T4267 1174-1183 VBP denotes represent
T4268 1184-1186 DT denotes an
T4270 1187-1196 JJ denotes important
T4269 1197-1201 NN denotes step
T4271 1202-1209 IN denotes towards
T4272 1210-1213 DT denotes the
T4273 1214-1230 NN denotes characterization
T4274 1231-1233 IN denotes of
T4275 1234-1243 NNS denotes functions
T4276 1244-1247 IN denotes for
T4277 1248-1251 DT denotes the
T4279 1252-1256 NN denotes Acdp
T4280 1257-1261 NN denotes gene
T4278 1262-1268 NN denotes family
T4281 1268-1269 . denotes .
R2353 T4051 T4052 poss Our,work
R2354 T4052 T4054 nsubj work,described
R2355 T4053 T4052 amod previous,work
R2356 T4055 T4054 aux has,described
R2357 T4056 T4057 amod human,genes
R2358 T4057 T4054 dobj genes,described
R2359 T4058 T4057 compound ACDP,genes
R2360 T4059 T4060 punct [,1
R2361 T4060 T4054 parataxis 1,described
R2362 T4061 T4060 punct ],1
R2363 T4062 T4054 punct .,described
R2364 T4064 T4065 det The,information
R2365 T4065 T4067 nsubj information,includes
R2366 T4066 T4065 amod new,information
R2367 T4067 T4072 ccomp includes,is
R2368 T4068 T4065 prep of,information
R2369 T4069 T4070 det the,work
R2370 T4070 T4068 pobj work,of
R2371 T4071 T4070 amod current,work
R2372 T4073 T4067 punct : ,includes
R2373 T4074 T4072 meta 1,is
R2374 T4075 T4074 punct ),1
R2375 T4076 T4074 punct .,1
R2376 T4077 T4072 nsubj It,is
R2377 T4078 T4079 det the,time
R2378 T4079 T4072 attr time,is
R2379 T4080 T4079 amod first,time
R2380 T4081 T4082 aux to,report
R2381 T4082 T4079 advcl report,time
R2382 T4083 T4084 det the,existence
R2383 T4084 T4082 dobj existence,report
R2384 T4085 T4084 prep of,existence
R2385 T4086 T4087 amod multiple,genes
R2386 T4087 T4085 pobj genes,of
R2387 T4088 T4087 compound Acdp,genes
R2388 T4089 T4082 prep in,report
R2389 T4090 T4091 amod other,mammals
R2390 T4091 T4089 pobj mammals,in
R2391 T4092 T4091 prep in,mammals
R2392 T4093 T4092 pobj addition,in
R2393 T4094 T4093 prep to,addition
R2394 T4095 T4094 pobj human,to
R2395 T4096 T4072 punct ", ",is
R2396 T4097 T4098 mark while,appears
R2397 T4098 T4072 advcl appears,is
R2398 T4099 T4098 nsubj Acdp,appears
R2399 T4100 T4101 aux to,be
R2400 T4101 T4098 xcomp be,appears
R2401 T4102 T4103 det a,gene
R2402 T4103 T4101 attr gene,be
R2403 T4104 T4103 amod single,gene
R2404 T4105 T4103 compound copy,gene
R2405 T4106 T4103 prep in,gene
R2406 T4107 T4108 amod lower,organisms
R2407 T4108 T4106 pobj organisms,in
R2408 T4109 T4110 amod such,as
R2409 T4110 T4101 prep as,be
R2410 T4111 T4110 prep in,as
R2411 T4112 T4113 compound C.,elegans
R2412 T4113 T4111 pobj elegans,in
R2413 T4114 T4113 punct ", ",elegans
R2414 T4115 T4113 conj yeasts,elegans
R2415 T4116 T4115 cc and,yeasts
R2416 T4117 T4115 conj bacteria,yeasts
R2417 T4118 T4072 punct .,is
R2418 T4120 T4121 nsubj We,suggested
R2419 T4121 T4124 ccomp suggested,generated
R2420 T4122 T4121 aux have,suggested
R2421 T4123 T4121 advmod also,suggested
R2422 T4125 T4126 det the,relationships
R2423 T4126 T4121 dobj relationships,suggested
R2424 T4127 T4126 amod evolutionary,relationships
R2425 T4128 T4126 prep of,relationships
R2426 T4129 T4130 compound Acdp,genes
R2427 T4130 T4128 pobj genes,of
R2428 T4131 T4130 prep in,genes
R2429 T4132 T4133 amod different,species
R2430 T4133 T4131 pobj species,in
R2431 T4134 T4135 punct (,tree
R2432 T4135 T4121 parataxis tree,suggested
R2433 T4136 T4135 amod phylogenetic,tree
R2434 T4137 T4135 punct ),tree
R2435 T4138 T4124 punct ;,generated
R2436 T4139 T4140 meta 2,are
R2437 T4140 T4124 ccomp are,generated
R2438 T4141 T4139 punct ),2
R2439 T4142 T4139 punct .,2
R2440 T4143 T4144 amod Molecular,cloning
R2441 T4144 T4140 nsubj cloning,are
R2442 T4145 T4144 cc and,cloning
R2443 T4146 T4144 conj characterization,cloning
R2444 T4147 T4144 prep of,cloning
R2445 T4148 T4149 amod murine,family
R2446 T4149 T4147 pobj family,of
R2447 T4150 T4149 compound Acdp,family
R2448 T4151 T4149 compound gene,family
R2449 T4152 T4140 acomp essential,are
R2450 T4153 T4140 prep for,are
R2451 T4154 T4153 pobj study,for
R2452 T4155 T4154 prep of,study
R2453 T4156 T4157 det this,family
R2454 T4157 T4155 pobj family,of
R2455 T4158 T4157 amod novel,family
R2456 T4159 T4157 compound gene,family
R2457 T4160 T4154 prep in,study
R2458 T4161 T4162 compound animal,model
R2459 T4162 T4160 pobj model,in
R2460 T4163 T4153 punct ", ",for
R2461 T4164 T4165 advmod e.g.,for
R2462 T4165 T4153 prep for,for
R2463 T4166 T4165 pobj generation,for
R2464 T4167 T4166 prep of,generation
R2465 T4168 T4169 nmod knockout,models
R2466 T4169 T4167 pobj models,of
R2467 T4170 T4168 cc or,knockout
R2468 T4171 T4168 conj transgenic,knockout
R2469 T4172 T4124 punct ;,generated
R2470 T4173 T4174 meta 3,demonstrated
R2471 T4174 T4124 ccomp demonstrated,generated
R2472 T4175 T4173 punct ),3
R2473 T4176 T4173 punct .,3
R2474 T4177 T4174 nsubj We,demonstrated
R2475 T4178 T4174 aux have,demonstrated
R2476 T4179 T4180 preconj both,DNA
R2477 T4180 T4181 nmod DNA,conservations
R2478 T4181 T4174 dobj conservations,demonstrated
R2479 T4182 T4180 cc and,DNA
R2480 T4183 T4184 compound amino,acid
R2481 T4184 T4180 conj acid,DNA
R2482 T4185 T4181 prep between,conservations
R2483 T4186 T4185 pobj mouse,between
R2484 T4187 T4186 cc and,mouse
R2485 T4188 T4186 conj human,mouse
R2486 T4189 T4174 prep for,demonstrated
R2487 T4190 T4191 det each,gene
R2488 T4191 T4189 pobj gene,for
R2489 T4192 T4191 compound Acdp,gene
R2490 T4193 T4191 cc and,gene
R2491 T4194 T4195 det the,family
R2492 T4195 T4191 conj family,gene
R2493 T4196 T4195 amod whole,family
R2494 T4197 T4195 compound Acdp,family
R2495 T4198 T4195 compound gene,family
R2496 T4199 T4191 punct ", ",gene
R2497 T4200 T4201 dep which,provide
R2498 T4201 T4191 relcl provide,gene
R2499 T4202 T4203 amod important,information
R2500 T4203 T4201 dobj information,provide
R2501 T4204 T4203 prep for,information
R2502 T4205 T4206 det the,possibility
R2503 T4206 T4204 pobj possibility,for
R2504 T4207 T4206 prep of,possibility
R2505 T4208 T4209 amod functional,redundancy
R2506 T4209 T4207 pobj redundancy,of
R2507 T4210 T4209 cc or,redundancy
R2508 T4211 T4209 conj overlap,redundancy
R2509 T4212 T4209 prep between,redundancy
R2510 T4213 T4214 compound Acdp,members
R2511 T4214 T4212 pobj members,between
R2512 T4215 T4124 punct ;,generated
R2513 T4216 T4124 meta 4,generated
R2514 T4217 T4216 punct ),4
R2515 T4218 T4216 punct .,4
R2516 T4219 T4124 nsubj We,generated
R2517 T4220 T4124 aux have,generated
R2518 T4221 T4124 dobj antibodies,generated
R2519 T4222 T4221 amod specific,antibodies
R2520 T4223 T4222 prep for,specific
R2521 T4224 T4223 pobj Acdp1,for
R2522 T4225 T4224 cc and,Acdp1
R2523 T4226 T4227 det all,proteins
R2524 T4227 T4224 conj proteins,Acdp1
R2525 T4228 T4227 compound Acdp,proteins
R2526 T4229 T4124 punct .,generated
R2527 T4231 T4232 det The,antibody
R2528 T4232 T4237 nsubj antibody,appears
R2529 T4233 T4232 compound Acdp1,antibody
R2530 T4234 T4235 compound C,terminus
R2531 T4235 T4232 compound terminus,antibody
R2532 T4236 T4235 punct -,terminus
R2533 T4238 T4239 aux to,recognize
R2534 T4239 T4237 xcomp recognize,appears
R2535 T4240 T4239 advmod specifically,recognize
R2536 T4241 T4239 dobj Acdp1,recognize
R2537 T4242 T4237 punct .,appears
R2538 T4244 T4245 advcl Using,demonstrated
R2539 T4246 T4247 det this,antibody
R2540 T4247 T4244 dobj antibody,Using
R2541 T4248 T4245 punct ", ",demonstrated
R2542 T4249 T4245 nsubj we,demonstrated
R2543 T4250 T4245 aux have,demonstrated
R2544 T4251 T4252 mark that,localized
R2545 T4252 T4245 ccomp localized,demonstrated
R2546 T4253 T4252 nsubjpass Acdp1,localized
R2547 T4254 T4252 auxpass is,localized
R2548 T4255 T4252 advmod predominantly,localized
R2549 T4256 T4252 prep on,localized
R2550 T4257 T4258 det the,membrane
R2551 T4258 T4256 pobj membrane,on
R2552 T4259 T4258 compound plasma,membrane
R2553 T4260 T4252 prep in,localized
R2554 T4261 T4262 compound hippocampus,neurons
R2555 T4262 T4260 pobj neurons,in
R2556 T4263 T4245 punct .,demonstrated
R2557 T4265 T4266 det These,results
R2558 T4266 T4267 nsubj results,represent
R2559 T4268 T4269 det an,step
R2560 T4269 T4267 dobj step,represent
R2561 T4270 T4269 amod important,step
R2562 T4271 T4269 prep towards,step
R2563 T4272 T4273 det the,characterization
R2564 T4273 T4271 pobj characterization,towards
R2565 T4274 T4273 prep of,characterization
R2566 T4275 T4274 pobj functions,of
R2567 T4276 T4273 prep for,characterization
R2568 T4277 T4278 det the,family
R2569 T4278 T4276 pobj family,for
R2570 T4279 T4278 compound Acdp,family
R2571 T4280 T4278 compound gene,family
R2572 T4281 T4267 punct .,represent