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PMC:314463 / 9395-14700 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2547 0-13 JJ denotes Morphological
T2548 14-24 NNS denotes Components
T2549 25-27 IN denotes of
T2550 28-40 JJ denotes Dorsoventral
T2552 41-45 NN denotes Skin
T2551 46-57 NNS denotes Differences
T2553 57-278 sentence denotes Besides the obvious change in hair color that frequently distinguishes dorsal from ventral skin, casual observation suggests there are additional differences in hair length, distribution of hair type, and skin thickness.
T2554 58-65 IN denotes Besides
T2556 66-69 DT denotes the
T2558 70-77 JJ denotes obvious
T2557 78-84 NN denotes change
T2559 85-87 IN denotes in
T2560 88-92 NN denotes hair
T2561 93-98 NN denotes color
T2562 99-103 WDT denotes that
T2564 104-114 RB denotes frequently
T2563 115-128 VBZ denotes distinguishes
T2565 129-135 JJ denotes dorsal
T2566 136-140 IN denotes from
T2567 141-148 JJ denotes ventral
T2568 149-153 NN denotes skin
T2569 153-155 , denotes ,
T2570 155-161 JJ denotes casual
T2571 162-173 NN denotes observation
T2555 174-182 VBZ denotes suggests
T2572 183-188 EX denotes there
T2573 189-192 VBP denotes are
T2574 193-203 JJ denotes additional
T2575 204-215 NNS denotes differences
T2576 216-218 IN denotes in
T2577 219-223 NN denotes hair
T2578 224-230 NN denotes length
T2579 230-232 , denotes ,
T2580 232-244 NN denotes distribution
T2581 245-247 IN denotes of
T2582 248-252 NN denotes hair
T2583 253-257 NN denotes type
T2584 257-259 , denotes ,
T2585 259-262 CC denotes and
T2586 263-267 NN denotes skin
T2587 268-277 NN denotes thickness
T2588 277-278 . denotes .
T2589 278-498 sentence denotes Furthermore, dorsoventral differences in pigmentation can represent differences in the number and/or differentiated state of pigment cells, as well as the type of pigment synthesized in response to expression of Agouti.
T2590 279-290 RB denotes Furthermore
T2592 290-292 , denotes ,
T2593 292-304 JJ denotes dorsoventral
T2594 305-316 NNS denotes differences
T2595 317-319 IN denotes in
T2596 320-332 NN denotes pigmentation
T2597 333-336 MD denotes can
T2591 337-346 VB denotes represent
T2598 347-358 NNS denotes differences
T2599 359-361 IN denotes in
T2600 362-365 DT denotes the
T2601 366-372 NN denotes number
T2602 373-376 CC denotes and
T2603 376-377 HYPH denotes /
T2604 377-379 CC denotes or
T2605 380-394 VBN denotes differentiated
T2606 395-400 NN denotes state
T2607 401-403 IN denotes of
T2608 404-411 NN denotes pigment
T2609 412-417 NNS denotes cells
T2610 417-419 , denotes ,
T2611 419-421 RB denotes as
T2613 422-426 RB denotes well
T2612 427-429 IN denotes as
T2614 430-433 DT denotes the
T2615 434-438 NN denotes type
T2616 439-441 IN denotes of
T2617 442-449 NN denotes pigment
T2618 450-461 VBN denotes synthesized
T2619 462-464 IN denotes in
T2620 465-473 NN denotes response
T2621 474-476 IN denotes to
T2622 477-487 NN denotes expression
T2623 488-490 IN denotes of
T2624 491-497 NN denotes Agouti
T2625 497-498 . denotes .
T2626 498-668 sentence denotes In particular, ventral hair of at/at animals can vary from cream-colored to reddish-yellow depending on age, strain background, and position along the dorsoventral axis.
T2627 499-501 IN denotes In
T2629 502-512 JJ denotes particular
T2630 512-514 , denotes ,
T2631 514-521 JJ denotes ventral
T2632 522-526 NN denotes hair
T2633 527-529 IN denotes of
T2634 530-532 NN denotes at
T2636 532-533 HYPH denotes /
T2635 533-535 NN denotes at
T2637 536-543 NNS denotes animals
T2638 544-547 MD denotes can
T2628 548-552 VB denotes vary
T2639 553-557 IN denotes from
T2640 558-563 NN denotes cream
T2642 563-564 HYPH denotes -
T2641 564-571 VBN denotes colored
T2643 572-574 IN denotes to
T2644 575-582 JJ denotes reddish
T2646 582-583 HYPH denotes -
T2645 583-589 JJ denotes yellow
T2647 590-599 VBG denotes depending
T2648 600-602 IN denotes on
T2649 603-606 NN denotes age
T2650 606-608 , denotes ,
T2651 608-614 NN denotes strain
T2652 615-625 NN denotes background
T2653 625-627 , denotes ,
T2654 627-630 CC denotes and
T2655 631-639 NN denotes position
T2656 640-645 IN denotes along
T2657 646-649 DT denotes the
T2659 650-662 JJ denotes dorsoventral
T2658 663-667 NN denotes axis
T2660 667-668 . denotes .
T2661 668-790 sentence denotes To evaluate the relationship among these components, we compared their features among mice of different Agouti genotypes.
T2662 669-671 TO denotes To
T2663 672-680 VB denotes evaluate
T2665 681-684 DT denotes the
T2666 685-697 NN denotes relationship
T2667 698-703 IN denotes among
T2668 704-709 DT denotes these
T2669 710-720 NNS denotes components
T2670 720-722 , denotes ,
T2671 722-724 PRP denotes we
T2664 725-733 VBD denotes compared
T2672 734-739 PRP$ denotes their
T2673 740-748 NNS denotes features
T2674 749-754 IN denotes among
T2675 755-759 NNS denotes mice
T2676 760-762 IN denotes of
T2677 763-772 JJ denotes different
T2679 773-779 NN denotes Agouti
T2678 780-789 NNS denotes genotypes
T2680 789-790 . denotes .
T2681 790-1072 sentence denotes Semiquantitative measurements of hair length plotted as a function of dorsoventral position reveal that the apparent sharp boundary between dorsal and ventral pigment compartments in at/at mice coincides with a more gradual change in both hair color and hair length (Figure 1A–1D).
T2682 791-807 JJ denotes Semiquantitative
T2683 808-820 NNS denotes measurements
T2685 821-823 IN denotes of
T2686 824-828 NN denotes hair
T2687 829-835 NN denotes length
T2688 836-843 VBN denotes plotted
T2689 844-846 IN denotes as
T2690 847-848 DT denotes a
T2691 849-857 NN denotes function
T2692 858-860 IN denotes of
T2693 861-873 JJ denotes dorsoventral
T2694 874-882 NN denotes position
T2684 883-889 VBP denotes reveal
T2695 890-894 IN denotes that
T2697 895-898 DT denotes the
T2699 899-907 JJ denotes apparent
T2700 908-913 JJ denotes sharp
T2698 914-922 NN denotes boundary
T2701 923-930 IN denotes between
T2702 931-937 JJ denotes dorsal
T2704 938-941 CC denotes and
T2705 942-949 JJ denotes ventral
T2706 950-957 NN denotes pigment
T2703 958-970 NNS denotes compartments
T2707 971-973 IN denotes in
T2708 974-976 NN denotes at
T2710 976-977 HYPH denotes /
T2709 977-979 NN denotes at
T2711 980-984 NNS denotes mice
T2696 985-994 VBZ denotes coincides
T2712 995-999 IN denotes with
T2713 1000-1001 DT denotes a
T2715 1002-1006 RBR denotes more
T2716 1007-1014 JJ denotes gradual
T2714 1015-1021 NN denotes change
T2717 1022-1024 IN denotes in
T2718 1025-1029 CC denotes both
T2720 1030-1034 NN denotes hair
T2719 1035-1040 NN denotes color
T2721 1041-1044 CC denotes and
T2722 1045-1049 NN denotes hair
T2723 1050-1056 NN denotes length
T2724 1057-1058 -LRB- denotes (
T2726 1058-1064 NN denotes Figure
T2725 1065-1067 CD denotes 1A
T2727 1067-1068 SYM denotes –
T2728 1068-1070 CD denotes 1D
T2729 1070-1071 -RRB- denotes )
T2730 1071-1072 . denotes .
T2731 1072-1304 sentence denotes Within the region of transition from dorsum to ventrum (Figure 1B), flank hairs from at/at mice become progressively shorter and exhibit increasing amounts of pheomelanin deposition progressing from the tip to the base of the hair.
T2732 1073-1079 IN denotes Within
T2734 1080-1083 DT denotes the
T2735 1084-1090 NN denotes region
T2736 1091-1093 IN denotes of
T2737 1094-1104 NN denotes transition
T2738 1105-1109 IN denotes from
T2739 1110-1116 NN denotes dorsum
T2740 1117-1119 IN denotes to
T2741 1120-1127 NN denotes ventrum
T2742 1128-1129 -LRB- denotes (
T2743 1129-1135 NN denotes Figure
T2744 1136-1138 CD denotes 1B
T2745 1138-1139 -RRB- denotes )
T2746 1139-1141 , denotes ,
T2747 1141-1146 NN denotes flank
T2748 1147-1152 NNS denotes hairs
T2749 1153-1157 IN denotes from
T2750 1158-1160 NN denotes at
T2752 1160-1161 HYPH denotes /
T2751 1161-1163 NN denotes at
T2753 1164-1168 NNS denotes mice
T2733 1169-1175 VBP denotes become
T2754 1176-1189 RB denotes progressively
T2755 1190-1197 JJR denotes shorter
T2756 1198-1201 CC denotes and
T2757 1202-1209 VBP denotes exhibit
T2758 1210-1220 VBG denotes increasing
T2759 1221-1228 NNS denotes amounts
T2760 1229-1231 IN denotes of
T2761 1232-1243 NN denotes pheomelanin
T2762 1244-1254 NN denotes deposition
T2763 1255-1266 VBG denotes progressing
T2764 1267-1271 IN denotes from
T2765 1272-1275 DT denotes the
T2766 1276-1279 NN denotes tip
T2767 1280-1282 IN denotes to
T2768 1283-1286 DT denotes the
T2769 1287-1291 NN denotes base
T2770 1292-1294 IN denotes of
T2771 1295-1298 DT denotes the
T2772 1299-1303 NN denotes hair
T2773 1303-1304 . denotes .
T2774 1304-1441 sentence denotes However, the region of transition for hair length is considerably broader than that for pigmentation and independent of Agouti genotype.
T2775 1305-1312 RB denotes However
T2777 1312-1314 , denotes ,
T2778 1314-1317 DT denotes the
T2779 1318-1324 NN denotes region
T2780 1325-1327 IN denotes of
T2781 1328-1338 NN denotes transition
T2782 1339-1342 IN denotes for
T2783 1343-1347 NN denotes hair
T2784 1348-1354 NN denotes length
T2776 1355-1357 VBZ denotes is
T2785 1358-1370 RB denotes considerably
T2786 1371-1378 JJR denotes broader
T2787 1379-1383 IN denotes than
T2788 1384-1388 DT denotes that
T2789 1389-1392 IN denotes for
T2790 1393-1405 NN denotes pigmentation
T2791 1406-1409 CC denotes and
T2792 1410-1421 JJ denotes independent
T2793 1422-1424 IN denotes of
T2794 1425-1431 NN denotes Agouti
T2795 1432-1440 NN denotes genotype
T2796 1440-1441 . denotes .
T2797 1441-1625 sentence denotes Although hair-cycle timing varies along the rostrocaudal axis, measurements of absolute hair length for mice matched for age and rostrocaudal level are remarkably similar (Figure 1D).
T2798 1442-1450 IN denotes Although
T2800 1451-1455 NN denotes hair
T2802 1455-1456 HYPH denotes -
T2801 1456-1461 NN denotes cycle
T2803 1462-1468 NN denotes timing
T2799 1469-1475 VBZ denotes varies
T2805 1476-1481 IN denotes along
T2806 1482-1485 DT denotes the
T2808 1486-1498 JJ denotes rostrocaudal
T2807 1499-1503 NN denotes axis
T2809 1503-1505 , denotes ,
T2810 1505-1517 NNS denotes measurements
T2811 1518-1520 IN denotes of
T2812 1521-1529 JJ denotes absolute
T2814 1530-1534 NN denotes hair
T2813 1535-1541 NN denotes length
T2815 1542-1545 IN denotes for
T2816 1546-1550 NNS denotes mice
T2817 1551-1558 VBN denotes matched
T2818 1559-1562 IN denotes for
T2819 1563-1566 NN denotes age
T2820 1567-1570 CC denotes and
T2821 1571-1583 JJ denotes rostrocaudal
T2822 1584-1589 NN denotes level
T2804 1590-1593 VBP denotes are
T2823 1594-1604 RB denotes remarkably
T2824 1605-1612 JJ denotes similar
T2825 1613-1614 -LRB- denotes (
T2826 1614-1620 NN denotes Figure
T2827 1621-1623 CD denotes 1D
T2828 1623-1624 -RRB- denotes )
T2829 1624-1625 . denotes .
T2830 1625-1804 sentence denotes Furthermore, measurements of relative hair length for animals of different age, size, and Agouti genotype also are very similar when normalized to body circumference (Figure 1C).
T2831 1626-1637 RB denotes Furthermore
T2833 1637-1639 , denotes ,
T2834 1639-1651 NNS denotes measurements
T2835 1652-1654 IN denotes of
T2836 1655-1663 JJ denotes relative
T2838 1664-1668 NN denotes hair
T2837 1669-1675 NN denotes length
T2839 1676-1679 IN denotes for
T2840 1680-1687 NNS denotes animals
T2841 1688-1690 IN denotes of
T2842 1691-1700 JJ denotes different
T2843 1701-1704 NN denotes age
T2844 1704-1706 , denotes ,
T2845 1706-1710 NN denotes size
T2846 1710-1712 , denotes ,
T2847 1712-1715 CC denotes and
T2848 1716-1722 NN denotes Agouti
T2849 1723-1731 NN denotes genotype
T2850 1732-1736 RB denotes also
T2832 1737-1740 VBP denotes are
T2851 1741-1745 RB denotes very
T2852 1746-1753 JJ denotes similar
T2853 1754-1758 WRB denotes when
T2854 1759-1769 VBN denotes normalized
T2855 1770-1772 IN denotes to
T2856 1773-1777 NN denotes body
T2857 1778-1791 NN denotes circumference
T2858 1792-1793 -LRB- denotes (
T2859 1793-1799 NN denotes Figure
T2860 1800-1802 CD denotes 1C
T2861 1802-1803 -RRB- denotes )
T2862 1803-1804 . denotes .
T2863 1804-2074 sentence denotes Taken together, these observations indicate that variation of hair length along the dorsoventral axis is stereotyped and maintained through multiple hair cycles, with a transition in hair length that is gradual and encompasses the pigment-type transition in at/at mice.
T2864 1805-1810 VBN denotes Taken
T2866 1811-1819 RB denotes together
T2867 1819-1821 , denotes ,
T2868 1821-1826 DT denotes these
T2869 1827-1839 NNS denotes observations
T2865 1840-1848 VBP denotes indicate
T2870 1849-1853 IN denotes that
T2872 1854-1863 NN denotes variation
T2873 1864-1866 IN denotes of
T2874 1867-1871 NN denotes hair
T2875 1872-1878 NN denotes length
T2876 1879-1884 IN denotes along
T2877 1885-1888 DT denotes the
T2879 1889-1901 JJ denotes dorsoventral
T2878 1902-1906 NN denotes axis
T2880 1907-1909 VBZ denotes is
T2871 1910-1921 VBN denotes stereotyped
T2881 1922-1925 CC denotes and
T2882 1926-1936 VBN denotes maintained
T2883 1937-1944 IN denotes through
T2884 1945-1953 JJ denotes multiple
T2886 1954-1958 NN denotes hair
T2885 1959-1965 NNS denotes cycles
T2887 1965-1967 , denotes ,
T2888 1967-1971 IN denotes with
T2889 1972-1973 DT denotes a
T2890 1974-1984 NN denotes transition
T2891 1985-1987 IN denotes in
T2892 1988-1992 NN denotes hair
T2893 1993-1999 NN denotes length
T2894 2000-2004 WDT denotes that
T2895 2005-2007 VBZ denotes is
T2896 2008-2015 JJ denotes gradual
T2897 2016-2019 CC denotes and
T2898 2020-2031 VBZ denotes encompasses
T2899 2032-2035 DT denotes the
T2901 2036-2043 NN denotes pigment
T2903 2043-2044 HYPH denotes -
T2902 2044-2048 NN denotes type
T2900 2049-2059 NN denotes transition
T2904 2060-2062 IN denotes in
T2905 2063-2065 NN denotes at
T2907 2065-2066 HYPH denotes /
T2906 2066-2068 NN denotes at
T2908 2069-2073 NNS denotes mice
T2909 2073-2074 . denotes .
T2910 2074-3272 sentence denotes Figure 1 Dorsoventral Skin Characteristics (A) Skin slices from animals of different age and genotype demonstrate similar patterns of hair-length variation along the dorsoventral axis (scale bar = 1 cm). (B) Enlarged area from (A), demonstrating the transition in hair length and color in at/at mice (scale bar = 0.375 cm). (C) Proportional hair length for (A) plotted as a function of relative position along the dorsoventral axis. (D) Hair length plotted as a function of absolute position along the dorsoventral axis for 8-wk-old BA strain mice. (E) Proportion of zigzag hairs (± SEM) differs slightly between dorsum and ventrum of inbred mice (p < 0.0001, χ2 test, n = 1,958, 1,477, 1,579, 1,502). (F) Differences in dorsal and ventral skin development at P4.5 (scale bar = 1 mm, upper; 200 μm, lower). (G) Differences in hair melanin content and DOPA staining for dorsum (d), flank (f), and ventrum (v) in ae/ae and at/at mice. The upper panel also demonstrates a cream-colored appearance of the at/at ventrum. The middle panel shows representative awls (scale bar = 100 μm). The lower panel shows DOPA-stained dermis (scale bar = 200 μm). Dorsal and ventral skin develop at different rates.
T2911 3221-3227 JJ denotes Dorsal
T2913 3228-3231 CC denotes and
T2914 3232-3239 JJ denotes ventral
T2912 3240-3244 NN denotes skin
T2915 3245-3252 VBP denotes develop
T2916 3253-3255 IN denotes at
T2917 3256-3265 JJ denotes different
T2918 3266-3271 NNS denotes rates
T2919 3271-3272 . denotes .
T2920 3272-3498 sentence denotes Transverse sections of skin at postnatal day 4.5 (P4.5) exhibit dorsal hair follicles that are noticeably more developed than ventral hair follicles, along with a gradual dorsoventral decrease in dermal thickness (Figure 1F).
T2921 3273-3283 JJ denotes Transverse
T2922 3284-3292 NNS denotes sections
T2924 3293-3295 IN denotes of
T2925 3296-3300 NN denotes skin
T2926 3301-3303 IN denotes at
T2927 3304-3313 JJ denotes postnatal
T2928 3314-3317 NN denotes day
T2929 3318-3321 CD denotes 4.5
T2930 3322-3323 -LRB- denotes (
T2931 3323-3327 NN denotes P4.5
T2932 3327-3328 -RRB- denotes )
T2923 3329-3336 VBP denotes exhibit
T2933 3337-3343 JJ denotes dorsal
T2935 3344-3348 NN denotes hair
T2934 3349-3358 NNS denotes follicles
T2936 3359-3363 WDT denotes that
T2937 3364-3367 VBP denotes are
T2938 3368-3378 RB denotes noticeably
T2940 3379-3383 RBR denotes more
T2939 3384-3393 JJ denotes developed
T2941 3394-3398 IN denotes than
T2942 3399-3406 JJ denotes ventral
T2944 3407-3411 NN denotes hair
T2943 3412-3421 NNS denotes follicles
T2945 3421-3423 , denotes ,
T2946 3423-3428 IN denotes along
T2947 3429-3433 IN denotes with
T2948 3434-3435 DT denotes a
T2950 3436-3443 JJ denotes gradual
T2951 3444-3456 JJ denotes dorsoventral
T2949 3457-3465 NN denotes decrease
T2952 3466-3468 IN denotes in
T2953 3469-3475 JJ denotes dermal
T2954 3476-3485 NN denotes thickness
T2955 3486-3487 -LRB- denotes (
T2956 3487-3493 NN denotes Figure
T2957 3494-3496 CD denotes 1F
T2958 3496-3497 -RRB- denotes )
T2959 3497-3498 . denotes .
T2960 3498-3695 sentence denotes However, differences in skin thickness disappear by 3–4 wk of age (Forsthoefel et al. 1966), and, overall, the proportion of different hair types is also similar in dorsa and ventra of adult mice.
T2961 3499-3506 RB denotes However
T2963 3506-3508 , denotes ,
T2964 3508-3519 NNS denotes differences
T2965 3520-3522 IN denotes in
T2966 3523-3527 NN denotes skin
T2967 3528-3537 NN denotes thickness
T2962 3538-3547 VBP denotes disappear
T2968 3548-3550 IN denotes by
T2969 3551-3552 CD denotes 3
T2971 3552-3553 SYM denotes –
T2970 3553-3554 CD denotes 4
T2972 3555-3557 NN denotes wk
T2973 3558-3560 IN denotes of
T2974 3561-3564 NN denotes age
T2975 3565-3566 -LRB- denotes (
T2976 3566-3577 NNP denotes Forsthoefel
T2977 3578-3580 FW denotes et
T2978 3581-3584 FW denotes al.
T2979 3585-3589 CD denotes 1966
T2980 3589-3590 -RRB- denotes )
T2981 3590-3592 , denotes ,
T2982 3592-3595 CC denotes and
T2983 3595-3597 , denotes ,
T2984 3597-3604 RB denotes overall
T2986 3604-3606 , denotes ,
T2987 3606-3609 DT denotes the
T2988 3610-3620 NN denotes proportion
T2989 3621-3623 IN denotes of
T2990 3624-3633 JJ denotes different
T2992 3634-3638 NN denotes hair
T2991 3639-3644 NNS denotes types
T2985 3645-3647 VBZ denotes is
T2993 3648-3652 RB denotes also
T2994 3653-3660 JJ denotes similar
T2995 3661-3663 IN denotes in
T2996 3664-3669 NNS denotes dorsa
T2997 3670-3673 CC denotes and
T2998 3674-3680 NNS denotes ventra
T2999 3681-3683 IN denotes of
T3000 3684-3689 JJ denotes adult
T3001 3690-3694 NNS denotes mice
T3002 3694-3695 . denotes .
T3003 3695-3989 sentence denotes In age-matched inbred mice, we observed a small decrease in the ratio of undercoat hairs (zigzags) to overcoat hairs (auchenes, awls, and guard hairs) in dorsum compared to ventrum (Figure 1E), but there was no consistent difference in hair-type distribution for outbred mice (data not shown).
T3004 3696-3698 IN denotes In
T3006 3699-3702 NN denotes age
T3008 3702-3703 HYPH denotes -
T3007 3703-3710 VBN denotes matched
T3010 3711-3717 JJ denotes inbred
T3009 3718-3722 NNS denotes mice
T3011 3722-3724 , denotes ,
T3012 3724-3726 PRP denotes we
T3005 3727-3735 VBD denotes observed
T3013 3736-3737 DT denotes a
T3015 3738-3743 JJ denotes small
T3014 3744-3752 NN denotes decrease
T3016 3753-3755 IN denotes in
T3017 3756-3759 DT denotes the
T3018 3760-3765 NN denotes ratio
T3019 3766-3768 IN denotes of
T3020 3769-3778 NN denotes undercoat
T3021 3779-3784 NNS denotes hairs
T3022 3785-3786 -LRB- denotes (
T3023 3786-3793 NNS denotes zigzags
T3024 3793-3794 -RRB- denotes )
T3025 3795-3797 IN denotes to
T3026 3798-3806 NN denotes overcoat
T3027 3807-3812 NNS denotes hairs
T3028 3813-3814 -LRB- denotes (
T3029 3814-3822 NNS denotes auchenes
T3030 3822-3824 , denotes ,
T3031 3824-3828 NNS denotes awls
T3032 3828-3830 , denotes ,
T3033 3830-3833 CC denotes and
T3034 3834-3839 NN denotes guard
T3035 3840-3845 NNS denotes hairs
T3036 3845-3846 -RRB- denotes )
T3037 3847-3849 IN denotes in
T3038 3850-3856 NN denotes dorsum
T3039 3857-3865 VBN denotes compared
T3040 3866-3868 IN denotes to
T3041 3869-3876 NN denotes ventrum
T3042 3877-3878 -LRB- denotes (
T3043 3878-3884 NN denotes Figure
T3044 3885-3887 CD denotes 1E
T3045 3887-3888 -RRB- denotes )
T3046 3888-3890 , denotes ,
T3047 3890-3893 CC denotes but
T3048 3894-3899 EX denotes there
T3049 3900-3903 VBD denotes was
T3050 3904-3906 DT denotes no
T3052 3907-3917 JJ denotes consistent
T3051 3918-3928 NN denotes difference
T3053 3929-3931 IN denotes in
T3054 3932-3936 NN denotes hair
T3056 3936-3937 HYPH denotes -
T3055 3937-3941 NN denotes type
T3057 3942-3954 NN denotes distribution
T3058 3955-3958 IN denotes for
T3059 3959-3966 JJ denotes outbred
T3060 3967-3971 NNS denotes mice
T3061 3972-3973 -LRB- denotes (
T3063 3973-3977 NNS denotes data
T3064 3978-3981 RB denotes not
T3062 3982-3987 VBN denotes shown
T3065 3987-3988 -RRB- denotes )
T3066 3988-3989 . denotes .
T3067 3989-4363 sentence denotes Differences between dorsal and ventral pigmentation of at/at mice are usually attributed to pigment-type differences caused by ventral-specific expression of Agouti, but animals homozygous for a null allele of Agouti, extreme nonagouti (ae), have ventral hairs that contain less melanin than dorsal hairs, giving a slightly paler appearance to the ventral coat (Figure 1G).
T3068 3990-4001 NNS denotes Differences
T3070 4002-4009 IN denotes between
T3071 4010-4016 JJ denotes dorsal
T3073 4017-4020 CC denotes and
T3074 4021-4028 JJ denotes ventral
T3072 4029-4041 NN denotes pigmentation
T3075 4042-4044 IN denotes of
T3076 4045-4047 NN denotes at
T3078 4047-4048 HYPH denotes /
T3077 4048-4050 NN denotes at
T3079 4051-4055 NNS denotes mice
T3080 4056-4059 VBP denotes are
T3081 4060-4067 RB denotes usually
T3069 4068-4078 VBN denotes attributed
T3082 4079-4081 IN denotes to
T3083 4082-4089 NN denotes pigment
T3085 4089-4090 HYPH denotes -
T3084 4090-4094 NN denotes type
T3086 4095-4106 NNS denotes differences
T3087 4107-4113 VBN denotes caused
T3088 4114-4116 IN denotes by
T3089 4117-4124 JJ denotes ventral
T3091 4124-4125 HYPH denotes -
T3090 4125-4133 JJ denotes specific
T3092 4134-4144 NN denotes expression
T3093 4145-4147 IN denotes of
T3094 4148-4154 NN denotes Agouti
T3095 4154-4156 , denotes ,
T3096 4156-4159 CC denotes but
T3097 4160-4167 NNS denotes animals
T3099 4168-4178 JJ denotes homozygous
T3100 4179-4182 IN denotes for
T3101 4183-4184 DT denotes a
T3103 4185-4189 JJ denotes null
T3102 4190-4196 NN denotes allele
T3104 4197-4199 IN denotes of
T3105 4200-4206 NN denotes Agouti
T3106 4206-4208 , denotes ,
T3107 4208-4215 JJ denotes extreme
T3108 4216-4225 NN denotes nonagouti
T3109 4226-4227 -LRB- denotes (
T3110 4227-4229 NN denotes ae
T3111 4229-4230 -RRB- denotes )
T3112 4230-4232 , denotes ,
T3098 4232-4236 VBP denotes have
T3113 4237-4244 JJ denotes ventral
T3114 4245-4250 NNS denotes hairs
T3115 4251-4255 WDT denotes that
T3116 4256-4263 VBP denotes contain
T3117 4264-4268 JJR denotes less
T3118 4269-4276 NN denotes melanin
T3119 4277-4281 IN denotes than
T3120 4282-4288 JJ denotes dorsal
T3121 4289-4294 NNS denotes hairs
T3122 4294-4296 , denotes ,
T3123 4296-4302 VBG denotes giving
T3124 4303-4304 DT denotes a
T3126 4305-4313 RB denotes slightly
T3127 4314-4319 JJ denotes paler
T3125 4320-4330 NN denotes appearance
T3128 4331-4333 IN denotes to
T3129 4334-4337 DT denotes the
T3131 4338-4345 JJ denotes ventral
T3130 4346-4350 NN denotes coat
T3132 4351-4352 -LRB- denotes (
T3133 4352-4358 NN denotes Figure
T3134 4359-4361 CD denotes 1G
T3135 4361-4362 -RRB- denotes )
T3136 4362-4363 . denotes .
T3137 4363-4535 sentence denotes Using DOPA staining as an indicator of tyrosinase activity, we observed a gradual dorsoventral transition in isolated dermis preparations from P4.5 ae/ae mice (Figure 1G).
T3138 4364-4369 VBG denotes Using
T3140 4370-4374 NN denotes DOPA
T3141 4375-4383 NN denotes staining
T3142 4384-4386 IN denotes as
T3143 4387-4389 DT denotes an
T3144 4390-4399 NN denotes indicator
T3145 4400-4402 IN denotes of
T3146 4403-4413 NN denotes tyrosinase
T3147 4414-4422 NN denotes activity
T3148 4422-4424 , denotes ,
T3149 4424-4426 PRP denotes we
T3139 4427-4435 VBD denotes observed
T3150 4436-4437 DT denotes a
T3152 4438-4445 JJ denotes gradual
T3153 4446-4458 JJ denotes dorsoventral
T3151 4459-4469 NN denotes transition
T3154 4470-4472 IN denotes in
T3155 4473-4481 VBN denotes isolated
T3157 4482-4488 NN denotes dermis
T3156 4489-4501 NNS denotes preparations
T3158 4502-4506 IN denotes from
T3159 4507-4511 NN denotes P4.5
T3161 4512-4514 NN denotes ae
T3163 4514-4515 HYPH denotes /
T3162 4515-4517 NN denotes ae
T3160 4518-4522 NNS denotes mice
T3164 4523-4524 -LRB- denotes (
T3165 4524-4530 NN denotes Figure
T3166 4531-4533 CD denotes 1G
T3167 4533-4534 -RRB- denotes )
T3168 4534-4535 . denotes .
T3169 4535-4780 sentence denotes By contrast, skin from at/at mice reveal an abrupt dorsoventral transition of DOPA staining, which probably reflects the additive effects of reduced melanin content (as in ae/ae mice) and downregulation of tyrosinase activity induced by Agouti.
T3170 4536-4538 IN denotes By
T3172 4539-4547 NN denotes contrast
T3173 4547-4549 , denotes ,
T3174 4549-4553 NN denotes skin
T3175 4554-4558 IN denotes from
T3176 4559-4561 NN denotes at
T3178 4561-4562 HYPH denotes /
T3177 4562-4564 NN denotes at
T3179 4565-4569 NNS denotes mice
T3171 4570-4576 VBP denotes reveal
T3180 4577-4579 DT denotes an
T3182 4580-4586 JJ denotes abrupt
T3183 4587-4599 JJ denotes dorsoventral
T3181 4600-4610 NN denotes transition
T3184 4611-4613 IN denotes of
T3185 4614-4618 NN denotes DOPA
T3186 4619-4627 NN denotes staining
T3187 4627-4629 , denotes ,
T3188 4629-4634 WDT denotes which
T3190 4635-4643 RB denotes probably
T3189 4644-4652 VBZ denotes reflects
T3191 4653-4656 DT denotes the
T3193 4657-4665 JJ denotes additive
T3192 4666-4673 NNS denotes effects
T3194 4674-4676 IN denotes of
T3195 4677-4684 VBN denotes reduced
T3197 4685-4692 NN denotes melanin
T3196 4693-4700 NN denotes content
T3198 4701-4702 -LRB- denotes (
T3199 4702-4704 IN denotes as
T3200 4705-4707 IN denotes in
T3201 4708-4710 NN denotes ae
T3203 4710-4711 HYPH denotes /
T3202 4711-4713 NN denotes ae
T3204 4714-4718 NNS denotes mice
T3205 4718-4719 -RRB- denotes )
T3206 4720-4723 CC denotes and
T3207 4724-4738 NN denotes downregulation
T3208 4739-4741 IN denotes of
T3209 4742-4752 NN denotes tyrosinase
T3210 4753-4761 NN denotes activity
T3211 4762-4769 VBN denotes induced
T3212 4770-4772 IN denotes by
T3213 4773-4779 NN denotes Agouti
T3214 4779-4780 . denotes .
T3215 4780-4913 sentence denotes Melanin content of individual hairs is likely to be influenced both by the number of pigment cells and their follicular environment.
T3216 4781-4788 NN denotes Melanin
T3217 4789-4796 NN denotes content
T3219 4797-4799 IN denotes of
T3220 4800-4810 JJ denotes individual
T3221 4811-4816 NNS denotes hairs
T3218 4817-4819 VBZ denotes is
T3222 4820-4826 JJ denotes likely
T3223 4827-4829 TO denotes to
T3225 4830-4832 VB denotes be
T3224 4833-4843 VBN denotes influenced
T3226 4844-4848 CC denotes both
T3227 4849-4851 IN denotes by
T3228 4852-4855 DT denotes the
T3229 4856-4862 NN denotes number
T3230 4863-4865 IN denotes of
T3231 4866-4873 NN denotes pigment
T3232 4874-4879 NNS denotes cells
T3233 4880-4883 CC denotes and
T3234 4884-4889 PRP$ denotes their
T3236 4890-4900 JJ denotes follicular
T3235 4901-4912 NN denotes environment
T3237 4912-4913 . denotes .
T3238 4913-5096 sentence denotes Regardless, dorsoventral differences in hair pigment content of ae/ae mice persist throughout multiple hair cycles into adulthood, similar to hair length (but unlike skin thickness).
T3239 4914-4924 RB denotes Regardless
T3241 4924-4926 , denotes ,
T3242 4926-4938 JJ denotes dorsoventral
T3243 4939-4950 NNS denotes differences
T3244 4951-4953 IN denotes in
T3245 4954-4958 NN denotes hair
T3247 4959-4966 NN denotes pigment
T3246 4967-4974 NN denotes content
T3248 4975-4977 IN denotes of
T3249 4978-4980 NN denotes ae
T3251 4980-4981 HYPH denotes /
T3250 4981-4983 NN denotes ae
T3252 4984-4988 NNS denotes mice
T3240 4989-4996 VBP denotes persist
T3253 4997-5007 IN denotes throughout
T3254 5008-5016 JJ denotes multiple
T3256 5017-5021 NN denotes hair
T3255 5022-5028 NNS denotes cycles
T3257 5029-5033 IN denotes into
T3258 5034-5043 NN denotes adulthood
T3259 5043-5045 , denotes ,
T3260 5045-5052 JJ denotes similar
T3261 5053-5055 IN denotes to
T3262 5056-5060 NN denotes hair
T3263 5061-5067 NN denotes length
T3264 5068-5069 -LRB- denotes (
T3265 5069-5072 CC denotes but
T3266 5073-5079 IN denotes unlike
T3267 5080-5084 NN denotes skin
T3268 5085-5094 NN denotes thickness
T3269 5094-5095 -RRB- denotes )
T3270 5095-5096 . denotes .
T3271 5096-5305 sentence denotes Thus, at least three characteristics distinguish dorsal from ventral skin: differences in pigment-type synthesis (depending on Agouti genotype), differences in hair length, and differences in melanin content.
T3272 5097-5101 RB denotes Thus
T3274 5101-5103 , denotes ,
T3275 5103-5105 RB denotes at
T3277 5106-5111 RBS denotes least
T3276 5112-5117 CD denotes three
T3278 5118-5133 NNS denotes characteristics
T3273 5134-5145 VBP denotes distinguish
T3279 5146-5152 JJ denotes dorsal
T3280 5153-5157 IN denotes from
T3281 5158-5165 JJ denotes ventral
T3282 5166-5170 NN denotes skin
T3283 5170-5172 : denotes :
T3284 5172-5183 NNS denotes differences
T3285 5184-5186 IN denotes in
T3286 5187-5194 NN denotes pigment
T3288 5194-5195 HYPH denotes -
T3287 5195-5199 NN denotes type
T3289 5200-5209 NN denotes synthesis
T3290 5210-5211 -LRB- denotes (
T3291 5211-5220 VBG denotes depending
T3292 5221-5223 IN denotes on
T3293 5224-5230 NN denotes Agouti
T3294 5231-5239 NN denotes genotype
T3295 5239-5240 -RRB- denotes )
T3296 5240-5242 , denotes ,
T3297 5242-5253 NNS denotes differences
T3298 5254-5256 IN denotes in
T3299 5257-5261 NN denotes hair
T3300 5262-5268 NN denotes length
T3301 5268-5270 , denotes ,
T3302 5270-5273 CC denotes and
T3303 5274-5285 NNS denotes differences
T3304 5286-5288 IN denotes in
T3305 5289-5296 NN denotes melanin
T3306 5297-5304 NN denotes content
T3307 5304-5305 . denotes .
R1556 T2547 T2548 amod Morphological,Components
R1557 T2549 T2548 prep of,Components
R1558 T2550 T2551 amod Dorsoventral,Differences
R1559 T2551 T2549 pobj Differences,of
R1560 T2552 T2551 compound Skin,Differences
R1561 T2554 T2555 prep Besides,suggests
R1562 T2556 T2557 det the,change
R1563 T2557 T2554 pobj change,Besides
R1564 T2558 T2557 amod obvious,change
R1565 T2559 T2557 prep in,change
R1566 T2560 T2561 compound hair,color
R1567 T2561 T2559 pobj color,in
R1568 T2562 T2563 dep that,distinguishes
R1569 T2563 T2557 relcl distinguishes,change
R1570 T2564 T2563 advmod frequently,distinguishes
R1571 T2565 T2563 dative dorsal,distinguishes
R1572 T2566 T2563 prep from,distinguishes
R1573 T2567 T2566 pobj ventral,from
R1574 T2568 T2563 dobj skin,distinguishes
R1575 T2569 T2555 punct ", ",suggests
R1576 T2570 T2571 amod casual,observation
R1577 T2571 T2555 nsubj observation,suggests
R1578 T2572 T2573 expl there,are
R1579 T2573 T2555 advcl are,suggests
R1580 T2574 T2575 amod additional,differences
R1581 T2575 T2573 attr differences,are
R1582 T2576 T2575 prep in,differences
R1583 T2577 T2578 compound hair,length
R1584 T2578 T2576 pobj length,in
R1585 T2579 T2578 punct ", ",length
R1586 T2580 T2578 conj distribution,length
R1587 T2581 T2580 prep of,distribution
R1588 T2582 T2583 compound hair,type
R1589 T2583 T2581 pobj type,of
R1590 T2584 T2580 punct ", ",distribution
R1591 T2585 T2580 cc and,distribution
R1592 T2586 T2587 compound skin,thickness
R1593 T2587 T2580 conj thickness,distribution
R1594 T2588 T2555 punct .,suggests
R1595 T2590 T2591 advmod Furthermore,represent
R1596 T2592 T2591 punct ", ",represent
R1597 T2593 T2594 amod dorsoventral,differences
R1598 T2594 T2591 nsubj differences,represent
R1599 T2595 T2594 prep in,differences
R1600 T2596 T2595 pobj pigmentation,in
R1601 T2597 T2591 aux can,represent
R1602 T2598 T2591 dobj differences,represent
R1603 T2599 T2598 prep in,differences
R1604 T2600 T2601 det the,number
R1605 T2601 T2599 pobj number,in
R1606 T2602 T2601 cc and,number
R1607 T2603 T2602 punct /,and
R1608 T2604 T2602 cc or,and
R1609 T2605 T2606 amod differentiated,state
R1610 T2606 T2601 conj state,number
R1611 T2607 T2601 prep of,number
R1612 T2608 T2609 compound pigment,cells
R1613 T2609 T2607 pobj cells,of
R1614 T2610 T2601 punct ", ",number
R1615 T2611 T2612 advmod as,as
R1616 T2612 T2601 cc as,number
R1617 T2613 T2612 advmod well,as
R1618 T2614 T2615 det the,type
R1619 T2615 T2601 conj type,number
R1620 T2616 T2615 prep of,type
R1621 T2617 T2616 pobj pigment,of
R1622 T2618 T2615 acl synthesized,type
R1623 T2619 T2618 prep in,synthesized
R1624 T2620 T2619 pobj response,in
R1625 T2621 T2620 prep to,response
R1626 T2622 T2621 pobj expression,to
R1627 T2623 T2622 prep of,expression
R1628 T2624 T2623 pobj Agouti,of
R1629 T2625 T2591 punct .,represent
R1630 T2627 T2628 prep In,vary
R1631 T2629 T2627 amod particular,In
R1632 T2630 T2628 punct ", ",vary
R1633 T2631 T2632 amod ventral,hair
R1634 T2632 T2628 nsubj hair,vary
R1635 T2633 T2632 prep of,hair
R1636 T2634 T2635 compound at,at
R1637 T2635 T2637 compound at,animals
R1638 T2636 T2635 punct /,at
R1639 T2637 T2633 pobj animals,of
R1640 T2638 T2628 aux can,vary
R1641 T2639 T2628 prep from,vary
R1642 T2640 T2641 npadvmod cream,colored
R1643 T2641 T2639 amod colored,from
R1644 T2642 T2641 punct -,colored
R1645 T2643 T2639 prep to,from
R1646 T2644 T2645 amod reddish,yellow
R1647 T2645 T2643 amod yellow,to
R1648 T2646 T2645 punct -,yellow
R1649 T2647 T2628 prep depending,vary
R1650 T2648 T2647 prep on,depending
R1651 T2649 T2648 pobj age,on
R1652 T2650 T2649 punct ", ",age
R1653 T2651 T2652 compound strain,background
R1654 T2652 T2649 conj background,age
R1655 T2653 T2652 punct ", ",background
R1656 T2654 T2652 cc and,background
R1657 T2655 T2652 conj position,background
R1658 T2656 T2655 prep along,position
R1659 T2657 T2658 det the,axis
R1660 T2658 T2656 pobj axis,along
R1661 T2659 T2658 amod dorsoventral,axis
R1662 T2660 T2628 punct .,vary
R1663 T2662 T2663 aux To,evaluate
R1664 T2663 T2664 advcl evaluate,compared
R1665 T2665 T2666 det the,relationship
R1666 T2666 T2663 dobj relationship,evaluate
R1667 T2667 T2666 prep among,relationship
R1668 T2668 T2669 det these,components
R1669 T2669 T2667 pobj components,among
R1670 T2670 T2664 punct ", ",compared
R1671 T2671 T2664 nsubj we,compared
R1672 T2672 T2673 poss their,features
R1673 T2673 T2664 dobj features,compared
R1674 T2674 T2664 prep among,compared
R1675 T2675 T2674 pobj mice,among
R1676 T2676 T2675 prep of,mice
R1677 T2677 T2678 amod different,genotypes
R1678 T2678 T2676 pobj genotypes,of
R1679 T2679 T2678 compound Agouti,genotypes
R1680 T2680 T2664 punct .,compared
R1681 T2682 T2683 amod Semiquantitative,measurements
R1682 T2683 T2684 nsubj measurements,reveal
R1683 T2685 T2683 prep of,measurements
R1684 T2686 T2687 compound hair,length
R1685 T2687 T2685 pobj length,of
R1686 T2688 T2683 acl plotted,measurements
R1687 T2689 T2688 prep as,plotted
R1688 T2690 T2691 det a,function
R1689 T2691 T2689 pobj function,as
R1690 T2692 T2691 prep of,function
R1691 T2693 T2694 amod dorsoventral,position
R1692 T2694 T2692 pobj position,of
R1693 T2695 T2696 mark that,coincides
R1694 T2696 T2684 ccomp coincides,reveal
R1695 T2697 T2698 det the,boundary
R1696 T2698 T2696 nsubj boundary,coincides
R1697 T2699 T2698 amod apparent,boundary
R1698 T2700 T2698 amod sharp,boundary
R1699 T2701 T2698 prep between,boundary
R1700 T2702 T2703 amod dorsal,compartments
R1701 T2703 T2701 pobj compartments,between
R1702 T2704 T2702 cc and,dorsal
R1703 T2705 T2702 conj ventral,dorsal
R1704 T2706 T2703 compound pigment,compartments
R1705 T2707 T2698 prep in,boundary
R1706 T2708 T2709 compound at,at
R1707 T2709 T2711 compound at,mice
R1708 T2710 T2709 punct /,at
R1709 T2711 T2707 pobj mice,in
R1710 T2712 T2696 prep with,coincides
R1711 T2713 T2714 det a,change
R1712 T2714 T2712 pobj change,with
R1713 T2715 T2716 advmod more,gradual
R1714 T2716 T2714 amod gradual,change
R1715 T2717 T2714 prep in,change
R1716 T2718 T2719 preconj both,color
R1717 T2719 T2717 pobj color,in
R1718 T2720 T2719 compound hair,color
R1719 T2721 T2719 cc and,color
R1720 T2722 T2723 compound hair,length
R1721 T2723 T2719 conj length,color
R1722 T2724 T2725 punct (,1A
R1723 T2725 T2696 parataxis 1A,coincides
R1724 T2726 T2725 nmod Figure,1A
R1725 T2727 T2728 punct –,1D
R1726 T2728 T2725 prep 1D,1A
R1727 T2729 T2725 punct ),1A
R1728 T2730 T2684 punct .,reveal
R1729 T2732 T2733 prep Within,become
R1730 T2734 T2735 det the,region
R1731 T2735 T2732 pobj region,Within
R1732 T2736 T2735 prep of,region
R1733 T2737 T2736 pobj transition,of
R1734 T2738 T2737 prep from,transition
R1735 T2739 T2738 pobj dorsum,from
R1736 T2740 T2737 prep to,transition
R1737 T2741 T2740 pobj ventrum,to
R1738 T2742 T2743 punct (,Figure
R1739 T2743 T2735 parataxis Figure,region
R1740 T2744 T2743 nummod 1B,Figure
R1741 T2745 T2743 punct ),Figure
R1742 T2746 T2733 punct ", ",become
R1743 T2747 T2748 compound flank,hairs
R1744 T2748 T2733 nsubj hairs,become
R1745 T2749 T2748 prep from,hairs
R1746 T2750 T2751 compound at,at
R1747 T2751 T2753 compound at,mice
R1748 T2752 T2751 punct /,at
R1749 T2753 T2749 pobj mice,from
R1750 T2754 T2755 advmod progressively,shorter
R1751 T2755 T2733 acomp shorter,become
R1752 T2756 T2733 cc and,become
R1753 T2757 T2733 conj exhibit,become
R1754 T2758 T2759 amod increasing,amounts
R1755 T2759 T2757 dobj amounts,exhibit
R1756 T2760 T2759 prep of,amounts
R1757 T2761 T2762 compound pheomelanin,deposition
R1758 T2762 T2760 pobj deposition,of
R1759 T2763 T2762 amod progressing,deposition
R1760 T2764 T2757 prep from,exhibit
R1761 T2765 T2766 det the,tip
R1762 T2766 T2764 pobj tip,from
R1763 T2767 T2764 prep to,from
R1764 T2768 T2769 det the,base
R1765 T2769 T2767 pobj base,to
R1766 T2770 T2764 prep of,from
R1767 T2771 T2772 det the,hair
R1768 T2772 T2770 pobj hair,of
R1769 T2773 T2733 punct .,become
R1770 T2775 T2776 advmod However,is
R1771 T2777 T2776 punct ", ",is
R1772 T2778 T2779 det the,region
R1773 T2779 T2776 nsubj region,is
R1774 T2780 T2779 prep of,region
R1775 T2781 T2780 pobj transition,of
R1776 T2782 T2776 prep for,is
R1777 T2783 T2784 compound hair,length
R1778 T2784 T2782 pobj length,for
R1779 T2785 T2786 advmod considerably,broader
R1780 T2786 T2776 acomp broader,is
R1781 T2787 T2786 prep than,broader
R1782 T2788 T2787 pobj that,than
R1783 T2789 T2788 prep for,that
R1784 T2790 T2789 pobj pigmentation,for
R1785 T2791 T2786 cc and,broader
R1786 T2792 T2786 conj independent,broader
R1787 T2793 T2792 prep of,independent
R1788 T2794 T2795 compound Agouti,genotype
R1789 T2795 T2793 pobj genotype,of
R1790 T2796 T2776 punct .,is
R1791 T2798 T2799 mark Although,varies
R1792 T2799 T2804 advcl varies,are
R1793 T2800 T2801 compound hair,cycle
R1794 T2801 T2803 compound cycle,timing
R1795 T2802 T2801 punct -,cycle
R1796 T2803 T2799 nsubj timing,varies
R1797 T2805 T2799 prep along,varies
R1798 T2806 T2807 det the,axis
R1799 T2807 T2805 pobj axis,along
R1800 T2808 T2807 amod rostrocaudal,axis
R1801 T2809 T2804 punct ", ",are
R1802 T2810 T2804 nsubj measurements,are
R1803 T2811 T2810 prep of,measurements
R1804 T2812 T2813 amod absolute,length
R1805 T2813 T2811 pobj length,of
R1806 T2814 T2813 compound hair,length
R1807 T2815 T2810 prep for,measurements
R1808 T2816 T2815 pobj mice,for
R1809 T2817 T2816 acl matched,mice
R1810 T2818 T2817 prep for,matched
R1811 T2819 T2818 pobj age,for
R1812 T2820 T2819 cc and,age
R1813 T2821 T2822 amod rostrocaudal,level
R1814 T2822 T2819 conj level,age
R1815 T2823 T2824 advmod remarkably,similar
R1816 T2824 T2804 acomp similar,are
R1817 T2825 T2826 punct (,Figure
R1818 T2826 T2804 parataxis Figure,are
R1819 T2827 T2826 nummod 1D,Figure
R1820 T2828 T2826 punct ),Figure
R1821 T2829 T2804 punct .,are
R1822 T2831 T2832 advmod Furthermore,are
R1823 T2833 T2832 punct ", ",are
R1824 T2834 T2832 nsubj measurements,are
R1825 T2835 T2834 prep of,measurements
R1826 T2836 T2837 amod relative,length
R1827 T2837 T2835 pobj length,of
R1828 T2838 T2837 compound hair,length
R1829 T2839 T2832 prep for,are
R1830 T2840 T2839 pobj animals,for
R1831 T2841 T2840 prep of,animals
R1832 T2842 T2843 amod different,age
R1833 T2843 T2841 pobj age,of
R1834 T2844 T2843 punct ", ",age
R1835 T2845 T2843 conj size,age
R1836 T2846 T2845 punct ", ",size
R1837 T2847 T2845 cc and,size
R1838 T2848 T2849 compound Agouti,genotype
R1839 T2849 T2845 conj genotype,size
R1840 T2850 T2832 advmod also,are
R1841 T2851 T2852 advmod very,similar
R1842 T2852 T2832 acomp similar,are
R1843 T2853 T2854 advmod when,normalized
R1844 T2854 T2832 advcl normalized,are
R1845 T2855 T2854 prep to,normalized
R1846 T2856 T2857 compound body,circumference
R1847 T2857 T2855 pobj circumference,to
R1848 T2858 T2859 punct (,Figure
R1849 T2859 T2832 parataxis Figure,are
R1850 T2860 T2859 nummod 1C,Figure
R1851 T2861 T2859 punct ),Figure
R1852 T2862 T2832 punct .,are
R1853 T2864 T2865 advcl Taken,indicate
R1854 T2866 T2864 advmod together,Taken
R1855 T2867 T2865 punct ", ",indicate
R1856 T2868 T2869 det these,observations
R1857 T2869 T2865 nsubj observations,indicate
R1858 T2870 T2871 mark that,stereotyped
R1859 T2871 T2865 ccomp stereotyped,indicate
R1860 T2872 T2871 nsubj variation,stereotyped
R1861 T2873 T2872 prep of,variation
R1862 T2874 T2875 compound hair,length
R1863 T2875 T2873 pobj length,of
R1864 T2876 T2872 prep along,variation
R1865 T2877 T2878 det the,axis
R1866 T2878 T2876 pobj axis,along
R1867 T2879 T2878 amod dorsoventral,axis
R1868 T2880 T2871 aux is,stereotyped
R1869 T2881 T2871 cc and,stereotyped
R1870 T2882 T2871 conj maintained,stereotyped
R1871 T2883 T2871 prep through,stereotyped
R1872 T2884 T2885 amod multiple,cycles
R1873 T2885 T2883 pobj cycles,through
R1874 T2886 T2885 compound hair,cycles
R1875 T2887 T2871 punct ", ",stereotyped
R1876 T2888 T2871 prep with,stereotyped
R1877 T2889 T2890 det a,transition
R1878 T2890 T2888 pobj transition,with
R1879 T2891 T2890 prep in,transition
R1880 T2892 T2893 compound hair,length
R1881 T2893 T2891 pobj length,in
R1882 T2894 T2895 dep that,is
R1883 T2895 T2890 relcl is,transition
R1884 T2896 T2895 acomp gradual,is
R1885 T2897 T2895 cc and,is
R1886 T2898 T2895 conj encompasses,is
R1887 T2899 T2900 det the,transition
R1888 T2900 T2898 dobj transition,encompasses
R1889 T2901 T2902 compound pigment,type
R1890 T2902 T2900 compound type,transition
R1891 T2903 T2902 punct -,type
R1892 T2904 T2895 prep in,is
R1893 T2905 T2906 compound at,at
R1894 T2906 T2908 compound at,mice
R1895 T2907 T2906 punct /,at
R1896 T2908 T2904 pobj mice,in
R1897 T2909 T2865 punct .,indicate
R1898 T2911 T2912 amod Dorsal,skin
R1899 T2912 T2915 nsubj skin,develop
R1900 T2913 T2911 cc and,Dorsal
R1901 T2914 T2911 conj ventral,Dorsal
R1902 T2916 T2915 prep at,develop
R1903 T2917 T2918 amod different,rates
R1904 T2918 T2916 pobj rates,at
R1905 T2919 T2915 punct .,develop
R1906 T2921 T2922 amod Transverse,sections
R1907 T2922 T2923 nsubj sections,exhibit
R1908 T2924 T2922 prep of,sections
R1909 T2925 T2924 pobj skin,of
R1910 T2926 T2922 prep at,sections
R1911 T2927 T2928 amod postnatal,day
R1912 T2928 T2926 pobj day,at
R1913 T2929 T2928 nummod 4.5,day
R1914 T2930 T2928 punct (,day
R1915 T2931 T2928 appos P4.5,day
R1916 T2932 T2928 punct ),day
R1917 T2933 T2934 amod dorsal,follicles
R1918 T2934 T2923 dobj follicles,exhibit
R1919 T2935 T2934 compound hair,follicles
R1920 T2936 T2937 dep that,are
R1921 T2937 T2934 relcl are,follicles
R1922 T2938 T2939 advmod noticeably,developed
R1923 T2939 T2937 acomp developed,are
R1924 T2940 T2939 advmod more,developed
R1925 T2941 T2939 prep than,developed
R1926 T2942 T2943 amod ventral,follicles
R1927 T2943 T2941 pobj follicles,than
R1928 T2944 T2943 compound hair,follicles
R1929 T2945 T2934 punct ", ",follicles
R1930 T2946 T2934 prep along,follicles
R1931 T2947 T2946 prep with,along
R1932 T2948 T2949 det a,decrease
R1933 T2949 T2947 pobj decrease,with
R1934 T2950 T2949 amod gradual,decrease
R1935 T2951 T2949 amod dorsoventral,decrease
R1936 T2952 T2949 prep in,decrease
R1937 T2953 T2954 amod dermal,thickness
R1938 T2954 T2952 pobj thickness,in
R1939 T2955 T2956 punct (,Figure
R1940 T2956 T2923 parataxis Figure,exhibit
R1941 T2957 T2956 nummod 1F,Figure
R1942 T2958 T2956 punct ),Figure
R1943 T2959 T2923 punct .,exhibit
R1944 T2961 T2962 advmod However,disappear
R1945 T2963 T2962 punct ", ",disappear
R1946 T2964 T2962 nsubj differences,disappear
R1947 T2965 T2964 prep in,differences
R1948 T2966 T2967 compound skin,thickness
R1949 T2967 T2965 pobj thickness,in
R1950 T2968 T2962 prep by,disappear
R1951 T2969 T2970 quantmod 3,4
R1952 T2970 T2972 nummod 4,wk
R1953 T2971 T2970 punct –,4
R1954 T2972 T2968 pobj wk,by
R1955 T2973 T2972 prep of,wk
R1956 T2974 T2973 pobj age,of
R1957 T2975 T2976 punct (,Forsthoefel
R1958 T2976 T2962 meta Forsthoefel,disappear
R1959 T2977 T2976 nmod et,Forsthoefel
R1960 T2978 T2976 nmod al.,Forsthoefel
R1961 T2979 T2976 nummod 1966,Forsthoefel
R1962 T2980 T2976 punct ),Forsthoefel
R1963 T2981 T2962 punct ", ",disappear
R1964 T2982 T2962 cc and,disappear
R1965 T2983 T2962 punct ", ",disappear
R1966 T2984 T2985 advmod overall,is
R1967 T2985 T2962 conj is,disappear
R1968 T2986 T2985 punct ", ",is
R1969 T2987 T2988 det the,proportion
R1970 T2988 T2985 nsubj proportion,is
R1971 T2989 T2988 prep of,proportion
R1972 T2990 T2991 amod different,types
R1973 T2991 T2989 pobj types,of
R1974 T2992 T2991 compound hair,types
R1975 T2993 T2994 advmod also,similar
R1976 T2994 T2985 acomp similar,is
R1977 T2995 T2985 prep in,is
R1978 T2996 T2995 pobj dorsa,in
R1979 T2997 T2996 cc and,dorsa
R1980 T2998 T2996 conj ventra,dorsa
R1981 T2999 T2996 prep of,dorsa
R1982 T3000 T3001 amod adult,mice
R1983 T3001 T2999 pobj mice,of
R1984 T3002 T2985 punct .,is
R1985 T3004 T3005 prep In,observed
R1986 T3006 T3007 npadvmod age,matched
R1987 T3007 T3009 amod matched,mice
R1988 T3008 T3007 punct -,matched
R1989 T3009 T3004 pobj mice,In
R1990 T3010 T3009 amod inbred,mice
R1991 T3011 T3005 punct ", ",observed
R1992 T3012 T3005 nsubj we,observed
R1993 T3013 T3014 det a,decrease
R1994 T3014 T3005 dobj decrease,observed
R1995 T3015 T3014 amod small,decrease
R1996 T3016 T3014 prep in,decrease
R1997 T3017 T3018 det the,ratio
R1998 T3018 T3016 pobj ratio,in
R1999 T3019 T3018 prep of,ratio
R2000 T3020 T3021 compound undercoat,hairs
R2001 T3021 T3019 pobj hairs,of
R2002 T3022 T3023 punct (,zigzags
R2003 T3023 T3021 parataxis zigzags,hairs
R2004 T3024 T3023 punct ),zigzags
R2005 T3025 T3018 prep to,ratio
R2006 T3026 T3027 compound overcoat,hairs
R2007 T3027 T3025 pobj hairs,to
R2008 T3028 T3027 punct (,hairs
R2009 T3029 T3027 appos auchenes,hairs
R2010 T3030 T3029 punct ", ",auchenes
R2011 T3031 T3029 conj awls,auchenes
R2012 T3032 T3031 punct ", ",awls
R2013 T3033 T3031 cc and,awls
R2014 T3034 T3035 compound guard,hairs
R2015 T3035 T3031 conj hairs,awls
R2016 T3036 T3005 punct ),observed
R2017 T3037 T3005 prep in,observed
R2018 T3038 T3037 pobj dorsum,in
R2019 T3039 T3005 prep compared,observed
R2020 T3040 T3039 prep to,compared
R2021 T3041 T3040 pobj ventrum,to
R2022 T3042 T3043 punct (,Figure
R2023 T3043 T3005 parataxis Figure,observed
R2024 T3044 T3043 nummod 1E,Figure
R2025 T3045 T3043 punct ),Figure
R2026 T3046 T3005 punct ", ",observed
R2027 T3047 T3005 cc but,observed
R2028 T3048 T3049 expl there,was
R2029 T3049 T3005 conj was,observed
R2030 T3050 T3051 det no,difference
R2031 T3051 T3049 attr difference,was
R2032 T3052 T3051 amod consistent,difference
R2033 T3053 T3051 prep in,difference
R2034 T3054 T3055 compound hair,type
R2035 T3055 T3057 compound type,distribution
R2036 T3056 T3055 punct -,type
R2037 T3057 T3053 pobj distribution,in
R2038 T3058 T3057 prep for,distribution
R2039 T3059 T3060 amod outbred,mice
R2040 T3060 T3058 pobj mice,for
R2041 T3061 T3062 punct (,shown
R2042 T3062 T3049 parataxis shown,was
R2043 T3063 T3062 nsubj data,shown
R2044 T3064 T3062 neg not,shown
R2045 T3065 T3062 punct ),shown
R2046 T3066 T3049 punct .,was
R2047 T3068 T3069 nsubjpass Differences,attributed
R2048 T3070 T3068 prep between,Differences
R2049 T3071 T3072 amod dorsal,pigmentation
R2050 T3072 T3070 pobj pigmentation,between
R2051 T3073 T3071 cc and,dorsal
R2052 T3074 T3071 conj ventral,dorsal
R2053 T3075 T3072 prep of,pigmentation
R2054 T3076 T3077 compound at,at
R2055 T3077 T3079 compound at,mice
R2056 T3078 T3077 punct /,at
R2057 T3079 T3075 pobj mice,of
R2058 T3080 T3069 auxpass are,attributed
R2059 T3081 T3069 advmod usually,attributed
R2060 T3082 T3069 prep to,attributed
R2061 T3083 T3084 compound pigment,type
R2062 T3084 T3086 compound type,differences
R2063 T3085 T3084 punct -,type
R2064 T3086 T3082 pobj differences,to
R2065 T3087 T3086 acl caused,differences
R2066 T3088 T3087 agent by,caused
R2067 T3089 T3090 amod ventral,specific
R2068 T3090 T3092 amod specific,expression
R2069 T3091 T3090 punct -,specific
R2070 T3092 T3088 pobj expression,by
R2071 T3093 T3092 prep of,expression
R2072 T3094 T3093 pobj Agouti,of
R2073 T3095 T3069 punct ", ",attributed
R2074 T3096 T3069 cc but,attributed
R2075 T3097 T3098 nsubj animals,have
R2076 T3098 T3069 conj have,attributed
R2077 T3099 T3097 amod homozygous,animals
R2078 T3100 T3099 prep for,homozygous
R2079 T3101 T3102 det a,allele
R2080 T3102 T3100 pobj allele,for
R2081 T3103 T3102 amod null,allele
R2082 T3104 T3102 prep of,allele
R2083 T3105 T3104 pobj Agouti,of
R2084 T3106 T3102 punct ", ",allele
R2085 T3107 T3108 amod extreme,nonagouti
R2086 T3108 T3102 appos nonagouti,allele
R2087 T3109 T3108 punct (,nonagouti
R2088 T3110 T3108 appos ae,nonagouti
R2089 T3111 T3108 punct ),nonagouti
R2090 T3112 T3098 punct ", ",have
R2091 T3113 T3114 amod ventral,hairs
R2092 T3114 T3098 dobj hairs,have
R2093 T3115 T3116 dep that,contain
R2094 T3116 T3114 relcl contain,hairs
R2095 T3117 T3118 amod less,melanin
R2096 T3118 T3116 dobj melanin,contain
R2097 T3119 T3118 prep than,melanin
R2098 T3120 T3121 amod dorsal,hairs
R2099 T3121 T3119 pobj hairs,than
R2100 T3122 T3116 punct ", ",contain
R2101 T3123 T3116 advcl giving,contain
R2102 T3124 T3125 det a,appearance
R2103 T3125 T3123 dobj appearance,giving
R2104 T3126 T3127 advmod slightly,paler
R2105 T3127 T3125 amod paler,appearance
R2106 T3128 T3123 dative to,giving
R2107 T3129 T3130 det the,coat
R2108 T3130 T3128 pobj coat,to
R2109 T3131 T3130 amod ventral,coat
R2110 T3132 T3133 punct (,Figure
R2111 T3133 T3098 parataxis Figure,have
R2112 T3134 T3133 nummod 1G,Figure
R2113 T3135 T3133 punct ),Figure
R2114 T3136 T3098 punct .,have
R2115 T3138 T3139 advcl Using,observed
R2116 T3140 T3141 compound DOPA,staining
R2117 T3141 T3138 dobj staining,Using
R2118 T3142 T3138 prep as,Using
R2119 T3143 T3144 det an,indicator
R2120 T3144 T3142 pobj indicator,as
R2121 T3145 T3144 prep of,indicator
R2122 T3146 T3147 compound tyrosinase,activity
R2123 T3147 T3145 pobj activity,of
R2124 T3148 T3139 punct ", ",observed
R2125 T3149 T3139 nsubj we,observed
R2126 T3150 T3151 det a,transition
R2127 T3151 T3139 dobj transition,observed
R2128 T3152 T3151 amod gradual,transition
R2129 T3153 T3151 amod dorsoventral,transition
R2130 T3154 T3139 prep in,observed
R2131 T3155 T3156 amod isolated,preparations
R2132 T3156 T3154 pobj preparations,in
R2133 T3157 T3156 compound dermis,preparations
R2134 T3158 T3156 prep from,preparations
R2135 T3159 T3160 compound P4.5,mice
R2136 T3160 T3158 pobj mice,from
R2137 T3161 T3162 compound ae,ae
R2138 T3162 T3160 compound ae,mice
R2139 T3163 T3162 punct /,ae
R2140 T3164 T3165 punct (,Figure
R2141 T3165 T3139 parataxis Figure,observed
R2142 T3166 T3165 nummod 1G,Figure
R2143 T3167 T3165 punct ),Figure
R2144 T3168 T3139 punct .,observed
R2145 T3170 T3171 prep By,reveal
R2146 T3172 T3170 pobj contrast,By
R2147 T3173 T3171 punct ", ",reveal
R2148 T3174 T3171 nsubj skin,reveal
R2149 T3175 T3174 prep from,skin
R2150 T3176 T3177 compound at,at
R2151 T3177 T3179 compound at,mice
R2152 T3178 T3177 punct /,at
R2153 T3179 T3175 pobj mice,from
R2154 T3180 T3181 det an,transition
R2155 T3181 T3171 dobj transition,reveal
R2156 T3182 T3181 amod abrupt,transition
R2157 T3183 T3181 amod dorsoventral,transition
R2158 T3184 T3181 prep of,transition
R2159 T3185 T3186 compound DOPA,staining
R2160 T3186 T3184 pobj staining,of
R2161 T3187 T3181 punct ", ",transition
R2162 T3188 T3189 dep which,reflects
R2163 T3189 T3181 relcl reflects,transition
R2164 T3190 T3189 advmod probably,reflects
R2165 T3191 T3192 det the,effects
R2166 T3192 T3189 dobj effects,reflects
R2167 T3193 T3192 amod additive,effects
R2168 T3194 T3192 prep of,effects
R2169 T3195 T3196 amod reduced,content
R2170 T3196 T3194 pobj content,of
R2171 T3197 T3196 compound melanin,content
R2172 T3198 T3196 punct (,content
R2173 T3199 T3196 prep as,content
R2174 T3200 T3199 prep in,as
R2175 T3201 T3202 compound ae,ae
R2176 T3202 T3204 compound ae,mice
R2177 T3203 T3202 punct /,ae
R2178 T3204 T3200 pobj mice,in
R2179 T3205 T3192 punct ),effects
R2180 T3206 T3192 cc and,effects
R2181 T3207 T3192 conj downregulation,effects
R2182 T3208 T3207 prep of,downregulation
R2183 T3209 T3210 compound tyrosinase,activity
R2184 T3210 T3208 pobj activity,of
R2185 T3211 T3210 acl induced,activity
R2186 T3212 T3211 agent by,induced
R2187 T3213 T3212 pobj Agouti,by
R2188 T3214 T3171 punct .,reveal
R2189 T3216 T3217 compound Melanin,content
R2190 T3217 T3218 nsubj content,is
R2191 T3219 T3217 prep of,content
R2192 T3220 T3221 amod individual,hairs
R2193 T3221 T3219 pobj hairs,of
R2194 T3222 T3218 acomp likely,is
R2195 T3223 T3224 aux to,influenced
R2196 T3224 T3222 xcomp influenced,likely
R2197 T3225 T3224 auxpass be,influenced
R2198 T3226 T3227 preconj both,by
R2199 T3227 T3224 agent by,influenced
R2200 T3228 T3229 det the,number
R2201 T3229 T3227 pobj number,by
R2202 T3230 T3229 prep of,number
R2203 T3231 T3232 compound pigment,cells
R2204 T3232 T3230 pobj cells,of
R2205 T3233 T3229 cc and,number
R2206 T3234 T3235 poss their,environment
R2207 T3235 T3229 conj environment,number
R2208 T3236 T3235 amod follicular,environment
R2209 T3237 T3218 punct .,is
R2210 T3239 T3240 advmod Regardless,persist
R2211 T3241 T3240 punct ", ",persist
R2212 T3242 T3243 amod dorsoventral,differences
R2213 T3243 T3240 nsubj differences,persist
R2214 T3244 T3243 prep in,differences
R2215 T3245 T3246 compound hair,content
R2216 T3246 T3244 pobj content,in
R2217 T3247 T3246 compound pigment,content
R2218 T3248 T3246 prep of,content
R2219 T3249 T3250 compound ae,ae
R2220 T3250 T3252 compound ae,mice
R2221 T3251 T3250 punct /,ae
R2222 T3252 T3248 pobj mice,of
R2223 T3253 T3240 prep throughout,persist
R2224 T3254 T3255 amod multiple,cycles
R2225 T3255 T3253 pobj cycles,throughout
R2226 T3256 T3255 compound hair,cycles
R2227 T3257 T3240 prep into,persist
R2228 T3258 T3257 pobj adulthood,into
R2229 T3259 T3240 punct ", ",persist
R2230 T3260 T3240 advcl similar,persist
R2231 T3261 T3260 prep to,similar
R2232 T3262 T3263 compound hair,length
R2233 T3263 T3261 pobj length,to
R2234 T3264 T3260 punct (,similar
R2235 T3265 T3260 cc but,similar
R2236 T3266 T3260 conj unlike,similar
R2237 T3267 T3268 compound skin,thickness
R2238 T3268 T3266 pobj thickness,unlike
R2239 T3269 T3240 punct ),persist
R2240 T3270 T3240 punct .,persist
R2241 T3272 T3273 advmod Thus,distinguish
R2242 T3274 T3273 punct ", ",distinguish
R2243 T3275 T3276 advmod at,three
R2244 T3276 T3278 nummod three,characteristics
R2245 T3277 T3276 advmod least,three
R2246 T3278 T3273 nsubj characteristics,distinguish
R2247 T3279 T3273 dative dorsal,distinguish
R2248 T3280 T3273 prep from,distinguish
R2249 T3281 T3280 pobj ventral,from
R2250 T3282 T3273 dobj skin,distinguish
R2251 T3283 T3273 punct : ,distinguish
R2252 T3284 T3273 dobj differences,distinguish
R2253 T3285 T3284 prep in,differences
R2254 T3286 T3287 compound pigment,type
R2255 T3287 T3289 compound type,synthesis
R2256 T3288 T3287 punct -,type
R2257 T3289 T3285 pobj synthesis,in
R2258 T3290 T3284 punct (,differences
R2259 T3291 T3284 prep depending,differences
R2260 T3292 T3291 prep on,depending
R2261 T3293 T3294 compound Agouti,genotype
R2262 T3294 T3292 pobj genotype,on
R2263 T3295 T3284 punct ),differences
R2264 T3296 T3284 punct ", ",differences
R2265 T3297 T3284 conj differences,differences
R2266 T3298 T3297 prep in,differences
R2267 T3299 T3300 compound hair,length
R2268 T3300 T3298 pobj length,in
R2269 T3301 T3297 punct ", ",differences
R2270 T3302 T3297 cc and,differences
R2271 T3303 T3297 conj differences,differences
R2272 T3304 T3303 prep in,differences
R2273 T3305 T3306 compound melanin,content
R2274 T3306 T3304 pobj content,in
R2275 T3307 T3273 punct .,distinguish