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PMC:314463 / 7793-9384 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T2014 0-2 TO denotes To
T2016 3-9 RBR denotes better
T2015 10-20 VB denotes understand
T2018 21-24 DT denotes the
T2019 25-35 NNS denotes mechanisms
T2020 36-40 WDT denotes that
T2021 41-45 VBP denotes give
T2022 46-50 NN denotes rise
T2023 51-53 IN denotes to
T2024 54-65 NNS denotes differences
T2025 66-73 IN denotes between
T2026 74-80 JJ denotes dorsal
T2028 81-84 CC denotes and
T2029 85-92 JJ denotes ventral
T2027 93-97 NN denotes skin
T2030 98-101 CC denotes and
T2031 102-104 IN denotes to
T2032 105-108 DT denotes the
T2033 109-117 NN denotes boundary
T2034 118-125 IN denotes between
T2035 126-130 PRP denotes them
T2036 130-132 , denotes ,
T2037 132-134 PRP denotes we
T2038 135-139 VBP denotes have
T2017 140-150 VBN denotes determined
T2039 151-154 WRB denotes how
T2041 155-162 JJ denotes several
T2043 163-174 JJ denotes morphologic
T2042 175-190 NNS denotes characteristics
T2040 191-195 VBP denotes vary
T2044 196-201 IN denotes along
T2045 202-205 DT denotes the
T2047 206-218 JJ denotes dorsoventral
T2046 219-223 NN denotes axis
T2048 224-226 IN denotes of
T2049 227-230 DT denotes the
T2050 231-236 NN denotes mouse
T2051 237-240 CC denotes and
T2052 241-244 WRB denotes how
T2054 245-250 DT denotes these
T2055 251-266 NNS denotes characteristics
T2053 267-277 VBP denotes correspond
T2056 278-280 IN denotes to
T2057 281-288 JJ denotes ventral
T2059 288-289 HYPH denotes -
T2058 289-297 JJ denotes specific
T2061 298-304 NN denotes Agouti
T2060 305-315 NN denotes expression
T2062 316-319 CC denotes and
T2063 320-323 DT denotes the
T2065 324-331 NN denotes lineage
T2064 332-340 NN denotes boundary
T2066 341-345 WDT denotes that
T2067 346-359 VBZ denotes distinguishes
T2068 360-366 NN denotes somite
T2069 367-371 IN denotes from
T2070 372-379 JJ denotes lateral
T2072 380-385 NN denotes plate
T2071 386-397 NNS denotes derivatives
T2073 397-398 . denotes .
T2074 398-703 sentence denotes Our results indicate that the apparent uniformity of the dorsoventral boundary represents the sum of independent mechanisms that affect melanocyte density and/or differentiation, pigment-type synthesis, and hair length; surprisingly, none of these coincide with the somite–lateral plate lineage boundary.
T2075 399-402 PRP$ denotes Our
T2076 403-410 NNS denotes results
T2077 411-419 VBP denotes indicate
T2079 420-424 IN denotes that
T2081 425-428 DT denotes the
T2083 429-437 JJ denotes apparent
T2082 438-448 NN denotes uniformity
T2084 449-451 IN denotes of
T2085 452-455 DT denotes the
T2087 456-468 JJ denotes dorsoventral
T2086 469-477 NN denotes boundary
T2080 478-488 VBZ denotes represents
T2088 489-492 DT denotes the
T2089 493-496 NN denotes sum
T2090 497-499 IN denotes of
T2091 500-511 JJ denotes independent
T2092 512-522 NNS denotes mechanisms
T2093 523-527 WDT denotes that
T2094 528-534 VBP denotes affect
T2095 535-545 NN denotes melanocyte
T2096 546-553 NN denotes density
T2097 554-557 CC denotes and
T2098 557-558 HYPH denotes /
T2099 558-560 CC denotes or
T2100 561-576 NN denotes differentiation
T2101 576-578 , denotes ,
T2102 578-585 NN denotes pigment
T2104 585-586 HYPH denotes -
T2103 586-590 NN denotes type
T2105 591-600 NN denotes synthesis
T2106 600-602 , denotes ,
T2107 602-605 CC denotes and
T2108 606-610 NN denotes hair
T2109 611-617 NN denotes length
T2110 617-618 : denotes ;
T2111 619-631 RB denotes surprisingly
T2112 631-633 , denotes ,
T2113 633-637 NN denotes none
T2114 638-640 IN denotes of
T2115 641-646 DT denotes these
T2078 647-655 VBP denotes coincide
T2116 656-660 IN denotes with
T2117 661-664 DT denotes the
T2119 665-671 NN denotes somite
T2121 671-672 HYPH denotes –
T2120 672-679 JJ denotes lateral
T2122 680-685 NN denotes plate
T2123 686-693 NN denotes lineage
T2118 694-702 NN denotes boundary
T2124 702-703 . denotes .
T2125 703-910 sentence denotes We also make use of a classical mouse mutation, droopy ear (Curry 1959), that produces a dorsal-to-ventral transformation of flank coat color by allowing expansion of the ventral-specific Agouti transcript.
T2126 704-706 PRP denotes We
T2128 707-711 RB denotes also
T2127 712-716 VBP denotes make
T2129 717-720 NN denotes use
T2130 721-723 IN denotes of
T2131 724-725 DT denotes a
T2133 726-735 JJ denotes classical
T2134 736-741 NN denotes mouse
T2132 742-750 NN denotes mutation
T2135 750-752 , denotes ,
T2136 752-758 JJ denotes droopy
T2137 759-762 NN denotes ear
T2138 763-764 -LRB- denotes (
T2139 764-769 NNP denotes Curry
T2140 770-774 CD denotes 1959
T2141 774-775 -RRB- denotes )
T2142 775-777 , denotes ,
T2143 777-781 WDT denotes that
T2144 782-790 VBZ denotes produces
T2145 791-792 DT denotes a
T2147 793-799 JJ denotes dorsal
T2148 799-800 HYPH denotes -
T2149 800-802 IN denotes to
T2150 802-803 HYPH denotes -
T2151 803-810 JJ denotes ventral
T2146 811-825 NN denotes transformation
T2152 826-828 IN denotes of
T2153 829-834 NN denotes flank
T2155 835-839 NN denotes coat
T2154 840-845 NN denotes color
T2156 846-848 IN denotes by
T2157 849-857 VBG denotes allowing
T2158 858-867 NN denotes expansion
T2159 868-870 IN denotes of
T2160 871-874 DT denotes the
T2162 875-882 JJ denotes ventral
T2164 882-883 HYPH denotes -
T2163 883-891 JJ denotes specific
T2165 892-898 NN denotes Agouti
T2161 899-909 NN denotes transcript
T2166 909-910 . denotes .
T2167 910-1176 sentence denotes By positional cloning and gene targeting, we identify an allele of droopy ear, deH, as a loss of function for Tbx15, which encodes a T-box transcription factor expressed in a dynamic and spatially restricted manner in the developing skin and musculoskeletal system.
T2168 911-913 IN denotes By
T2170 914-924 JJ denotes positional
T2171 925-932 NN denotes cloning
T2172 933-936 CC denotes and
T2173 937-941 NN denotes gene
T2174 942-951 NN denotes targeting
T2175 951-953 , denotes ,
T2176 953-955 PRP denotes we
T2169 956-964 VBP denotes identify
T2177 965-967 DT denotes an
T2178 968-974 NN denotes allele
T2179 975-977 IN denotes of
T2180 978-984 JJ denotes droopy
T2181 985-988 NN denotes ear
T2182 988-990 , denotes ,
T2183 990-993 NN denotes deH
T2184 993-995 , denotes ,
T2185 995-997 IN denotes as
T2186 998-999 DT denotes a
T2187 1000-1004 NN denotes loss
T2188 1005-1007 IN denotes of
T2189 1008-1016 NN denotes function
T2190 1017-1020 IN denotes for
T2191 1021-1026 NN denotes Tbx15
T2192 1026-1028 , denotes ,
T2193 1028-1033 WDT denotes which
T2194 1034-1041 VBZ denotes encodes
T2195 1042-1043 DT denotes a
T2197 1044-1045 NN denotes T
T2199 1045-1046 HYPH denotes -
T2198 1046-1049 NN denotes box
T2200 1050-1063 NN denotes transcription
T2196 1064-1070 NN denotes factor
T2201 1071-1080 VBN denotes expressed
T2202 1081-1083 IN denotes in
T2203 1084-1085 DT denotes a
T2205 1086-1093 JJ denotes dynamic
T2206 1094-1097 CC denotes and
T2207 1098-1107 RB denotes spatially
T2208 1108-1118 JJ denotes restricted
T2204 1119-1125 NN denotes manner
T2209 1126-1128 IN denotes in
T2210 1129-1132 DT denotes the
T2212 1133-1143 VBG denotes developing
T2211 1144-1148 NN denotes skin
T2213 1149-1152 CC denotes and
T2214 1153-1168 JJ denotes musculoskeletal
T2215 1169-1175 NN denotes system
T2216 1175-1176 . denotes .
T2217 1176-1360 sentence denotes Embryonic expression and transplantation studies suggest that Tbx15 is required to establish certain characteristics of dorsal patterning in mesenchymal cells of the developing flank.
T2218 1177-1186 JJ denotes Embryonic
T2220 1187-1197 NN denotes expression
T2221 1198-1201 CC denotes and
T2222 1202-1217 NN denotes transplantation
T2219 1218-1225 NNS denotes studies
T2223 1226-1233 VBP denotes suggest
T2224 1234-1238 IN denotes that
T2226 1239-1244 NN denotes Tbx15
T2227 1245-1247 VBZ denotes is
T2225 1248-1256 VBN denotes required
T2228 1257-1259 TO denotes to
T2229 1260-1269 VB denotes establish
T2230 1270-1277 JJ denotes certain
T2231 1278-1293 NNS denotes characteristics
T2232 1294-1296 IN denotes of
T2233 1297-1303 JJ denotes dorsal
T2234 1304-1314 NN denotes patterning
T2235 1315-1317 IN denotes in
T2236 1318-1329 JJ denotes mesenchymal
T2237 1330-1335 NNS denotes cells
T2238 1336-1338 IN denotes of
T2239 1339-1342 DT denotes the
T2241 1343-1353 VBG denotes developing
T2240 1354-1359 NN denotes flank
T2242 1359-1360 . denotes .
T2243 1360-1591 sentence denotes These results identify a previously unappreciated aspect of dorsoventral patterning that is widely represented in furred mammals and provide insight into the mechanisms that underlie region-specific differences in body morphology.
T2244 1361-1366 DT denotes These
T2245 1367-1374 NNS denotes results
T2246 1375-1383 VBP denotes identify
T2247 1384-1385 DT denotes a
T2249 1386-1396 RB denotes previously
T2250 1397-1410 JJ denotes unappreciated
T2248 1411-1417 NN denotes aspect
T2251 1418-1420 IN denotes of
T2252 1421-1433 JJ denotes dorsoventral
T2253 1434-1444 NN denotes patterning
T2254 1445-1449 WDT denotes that
T2256 1450-1452 VBZ denotes is
T2257 1453-1459 RB denotes widely
T2255 1460-1471 VBN denotes represented
T2258 1472-1474 IN denotes in
T2259 1475-1481 JJ denotes furred
T2260 1482-1489 NNS denotes mammals
T2261 1490-1493 CC denotes and
T2262 1494-1501 VBP denotes provide
T2263 1502-1509 NN denotes insight
T2264 1510-1514 IN denotes into
T2265 1515-1518 DT denotes the
T2266 1519-1529 NNS denotes mechanisms
T2267 1530-1534 WDT denotes that
T2268 1535-1543 VBP denotes underlie
T2269 1544-1550 NN denotes region
T2271 1550-1551 HYPH denotes -
T2270 1551-1559 JJ denotes specific
T2272 1560-1571 NNS denotes differences
T2273 1572-1574 IN denotes in
T2274 1575-1579 NN denotes body
T2275 1580-1590 NN denotes morphology
T2276 1590-1591 . denotes .
R1301 T2014 T2015 aux To,understand
R1302 T2015 T2017 advcl understand,determined
R1306 T2016 T2015 advmod better,understand
R1307 T2097 T2096 cc and,density
R1308 T2018 T2019 det the,mechanisms
R1309 T2019 T2015 dobj mechanisms,understand
R1310 T2020 T2021 dep that,give
R1311 T2098 T2097 punct /,and
R1312 T2021 T2019 relcl give,mechanisms
R1313 T2022 T2021 dobj rise,give
R1314 T2023 T2021 prep to,give
R1315 T2024 T2023 pobj differences,to
R1316 T2099 T2097 cc or,and
R1317 T2025 T2024 prep between,differences
R1318 T2026 T2027 amod dorsal,skin
R1319 T2027 T2025 pobj skin,between
R1320 T2028 T2026 cc and,dorsal
R1321 T2029 T2026 conj ventral,dorsal
R1322 T2030 T2023 cc and,to
R1323 T2100 T2096 conj differentiation,density
R1324 T2031 T2023 conj to,to
R1325 T2032 T2033 det the,boundary
R1326 T2033 T2031 pobj boundary,to
R1327 T2101 T2096 punct ", ",density
R1328 T2034 T2033 prep between,boundary
R1329 T2035 T2034 pobj them,between
R1330 T2036 T2017 punct ", ",determined
R1331 T2102 T2103 compound pigment,type
R1332 T2037 T2017 nsubj we,determined
R1333 T2038 T2017 aux have,determined
R1334 T2103 T2105 compound type,synthesis
R1335 T2039 T2040 advmod how,vary
R1336 T2040 T2017 advcl vary,determined
R1337 T2041 T2042 amod several,characteristics
R1338 T2104 T2103 punct -,type
R1339 T2042 T2040 nsubj characteristics,vary
R1340 T2043 T2042 amod morphologic,characteristics
R1341 T2044 T2040 prep along,vary
R1342 T2105 T2096 conj synthesis,density
R1343 T2045 T2046 det the,axis
R1344 T2046 T2044 pobj axis,along
R1345 T2047 T2046 amod dorsoventral,axis
R1346 T2106 T2105 punct ", ",synthesis
R1347 T2048 T2046 prep of,axis
R1348 T2049 T2050 det the,mouse
R1349 T2107 T2105 cc and,synthesis
R1350 T2050 T2048 pobj mouse,of
R1351 T2051 T2040 cc and,vary
R1352 T2052 T2053 advmod how,correspond
R1353 T2108 T2109 compound hair,length
R1354 T2053 T2040 conj correspond,vary
R1355 T2054 T2055 det these,characteristics
R1356 T2055 T2053 nsubj characteristics,correspond
R1357 T2109 T2105 conj length,synthesis
R1358 T2056 T2053 prep to,correspond
R1359 T2057 T2058 amod ventral,specific
R1360 T2110 T2078 punct ;,coincide
R1361 T2058 T2060 amod specific,expression
R1362 T2059 T2058 punct -,specific
R1363 T2060 T2056 pobj expression,to
R1364 T2061 T2060 compound Agouti,expression
R1365 T2111 T2078 advmod surprisingly,coincide
R1366 T2062 T2060 cc and,expression
R1367 T2112 T2078 punct ", ",coincide
R1368 T2063 T2064 det the,boundary
R1369 T2064 T2060 conj boundary,expression
R1370 T2065 T2064 compound lineage,boundary
R1371 T2066 T2067 dep that,distinguishes
R1372 T2067 T2064 relcl distinguishes,boundary
R1373 T2068 T2067 dobj somite,distinguishes
R1374 T2113 T2078 nsubj none,coincide
R1375 T2114 T2113 prep of,none
R1376 T2069 T2067 prep from,distinguishes
R1377 T2070 T2071 amod lateral,derivatives
R1378 T2071 T2069 pobj derivatives,from
R1379 T2072 T2071 compound plate,derivatives
R1380 T2115 T2114 pobj these,of
R1381 T2073 T2017 punct .,determined
R1382 T2075 T2076 poss Our,results
R1383 T2116 T2078 prep with,coincide
R1384 T2076 T2077 nsubj results,indicate
R1385 T2077 T2078 ccomp indicate,coincide
R1386 T2117 T2118 det the,boundary
R1387 T2079 T2080 mark that,represents
R1388 T2080 T2077 ccomp represents,indicate
R1389 T2118 T2116 pobj boundary,with
R1390 T2081 T2082 det the,uniformity
R1391 T2082 T2080 nsubj uniformity,represents
R1392 T2119 T2120 npadvmod somite,lateral
R1393 T2083 T2082 amod apparent,uniformity
R1394 T2084 T2082 prep of,uniformity
R1395 T2085 T2086 det the,boundary
R1396 T2120 T2118 amod lateral,boundary
R1397 T2086 T2084 pobj boundary,of
R1398 T2087 T2086 amod dorsoventral,boundary
R1399 T2088 T2089 det the,sum
R1400 T2121 T2120 punct –,lateral
R1401 T2089 T2080 dobj sum,represents
R1402 T2090 T2089 prep of,sum
R1403 T2091 T2092 amod independent,mechanisms
R1404 T2122 T2123 compound plate,lineage
R1405 T2092 T2090 pobj mechanisms,of
R1406 T2093 T2094 dep that,affect
R1407 T2094 T2092 relcl affect,mechanisms
R1408 T2123 T2118 compound lineage,boundary
R1409 T2095 T2096 compound melanocyte,density
R1410 T2124 T2078 punct .,coincide
R1411 T2096 T2094 dobj density,affect
R1412 T2126 T2127 nsubj We,make
R1413 T2128 T2127 advmod also,make
R1414 T2129 T2127 dobj use,make
R1415 T2130 T2127 prep of,make
R1416 T2131 T2132 det a,mutation
R1417 T2132 T2130 pobj mutation,of
R1418 T2133 T2132 amod classical,mutation
R1419 T2203 T2204 det a,manner
R1420 T2134 T2132 compound mouse,mutation
R1421 T2204 T2202 pobj manner,in
R1422 T2205 T2204 amod dynamic,manner
R1423 T2206 T2205 cc and,dynamic
R1424 T2207 T2208 advmod spatially,restricted
R1425 T2208 T2205 conj restricted,dynamic
R1426 T2209 T2201 prep in,expressed
R1427 T2135 T2132 punct ", ",mutation
R1428 T2210 T2211 det the,skin
R1429 T2211 T2209 pobj skin,in
R1430 T2212 T2211 amod developing,skin
R1431 T2136 T2137 amod droopy,ear
R1432 T2213 T2211 cc and,skin
R1433 T2214 T2215 amod musculoskeletal,system
R1434 T2215 T2211 conj system,skin
R1435 T2137 T2132 appos ear,mutation
R1436 T2216 T2169 punct .,identify
R1437 T2138 T2139 punct (,Curry
R1438 T2218 T2219 amod Embryonic,studies
R1439 T2219 T2223 nsubj studies,suggest
R1440 T2220 T2219 nmod expression,studies
R1441 T2139 T2132 meta Curry,mutation
R1442 T2221 T2220 cc and,expression
R1443 T2222 T2220 conj transplantation,expression
R1444 T2140 T2139 nummod 1959,Curry
R1445 T2224 T2225 mark that,required
R1446 T2225 T2223 ccomp required,suggest
R1447 T2226 T2225 nsubjpass Tbx15,required
R1448 T2141 T2139 punct ),Curry
R1449 T2227 T2225 auxpass is,required
R1450 T2228 T2229 aux to,establish
R1451 T2229 T2225 xcomp establish,required
R1452 T2142 T2132 punct ", ",mutation
R1453 T2230 T2231 amod certain,characteristics
R1454 T2231 T2229 dobj characteristics,establish
R1455 T2232 T2231 prep of,characteristics
R1456 T2233 T2234 amod dorsal,patterning
R1457 T2143 T2144 dep that,produces
R1458 T2234 T2232 pobj patterning,of
R1459 T2235 T2229 prep in,establish
R1460 T2144 T2132 relcl produces,mutation
R1461 T2236 T2237 amod mesenchymal,cells
R1462 T2237 T2235 pobj cells,in
R1463 T2238 T2237 prep of,cells
R1464 T2145 T2146 det a,transformation
R1465 T2146 T2144 dobj transformation,produces
R1466 T2147 T2146 amod dorsal,transformation
R1467 T2239 T2240 det the,flank
R1468 T2240 T2238 pobj flank,of
R1469 T2148 T2147 punct -,dorsal
R1470 T2241 T2240 amod developing,flank
R1471 T2242 T2223 punct .,suggest
R1472 T2149 T2147 prep to,dorsal
R1473 T2244 T2245 det These,results
R1474 T2245 T2246 nsubj results,identify
R1475 T2247 T2248 det a,aspect
R1476 T2150 T2149 punct -,to
R1477 T2248 T2246 dobj aspect,identify
R1478 T2249 T2250 advmod previously,unappreciated
R1479 T2250 T2248 amod unappreciated,aspect
R1480 T2151 T2149 amod ventral,to
R1481 T2251 T2248 prep of,aspect
R1482 T2252 T2253 amod dorsoventral,patterning
R1483 T2253 T2251 pobj patterning,of
R1484 T2254 T2255 dep that,represented
R1485 T2152 T2146 prep of,transformation
R1486 T2255 T2248 relcl represented,aspect
R1487 T2256 T2255 auxpass is,represented
R1488 T2257 T2255 advmod widely,represented
R1489 T2153 T2154 compound flank,color
R1490 T2258 T2255 prep in,represented
R1491 T2259 T2260 amod furred,mammals
R1492 T2154 T2152 pobj color,of
R1493 T2260 T2258 pobj mammals,in
R1494 T2261 T2255 cc and,represented
R1495 T2262 T2255 conj provide,represented
R1496 T2263 T2262 dobj insight,provide
R1497 T2155 T2154 compound coat,color
R1498 T2264 T2263 prep into,insight
R1499 T2265 T2266 det the,mechanisms
R1500 T2266 T2264 pobj mechanisms,into
R1501 T2156 T2144 prep by,produces
R1502 T2267 T2268 dep that,underlie
R1503 T2268 T2266 relcl underlie,mechanisms
R1504 T2269 T2270 npadvmod region,specific
R1505 T2157 T2156 pcomp allowing,by
R1506 T2270 T2272 amod specific,differences
R1507 T2271 T2270 punct -,specific
R1508 T2272 T2268 dobj differences,underlie
R1509 T2158 T2157 dobj expansion,allowing
R1510 T2273 T2272 prep in,differences
R1511 T2274 T2275 compound body,morphology
R1512 T2159 T2158 prep of,expansion
R1513 T2275 T2273 pobj morphology,in
R1514 T2276 T2246 punct .,identify
R1515 T2160 T2161 det the,transcript
R1516 T2161 T2159 pobj transcript,of
R1517 T2162 T2163 amod ventral,specific
R1518 T2163 T2161 amod specific,transcript
R1519 T2164 T2163 punct -,specific
R1520 T2165 T2161 compound Agouti,transcript
R1521 T2166 T2127 punct .,make
R1522 T2168 T2169 prep By,identify
R1523 T2170 T2171 amod positional,cloning
R1524 T2171 T2168 pobj cloning,By
R1525 T2172 T2171 cc and,cloning
R1526 T2173 T2174 compound gene,targeting
R1527 T2174 T2171 conj targeting,cloning
R1528 T2175 T2169 punct ", ",identify
R1529 T2176 T2169 nsubj we,identify
R1530 T2177 T2178 det an,allele
R1531 T2178 T2169 dobj allele,identify
R1532 T2179 T2178 prep of,allele
R1533 T2180 T2181 amod droopy,ear
R1534 T2181 T2179 pobj ear,of
R1535 T2182 T2178 punct ", ",allele
R1536 T2183 T2178 appos deH,allele
R1537 T2184 T2169 punct ", ",identify
R1538 T2185 T2169 prep as,identify
R1539 T2186 T2187 det a,loss
R1540 T2187 T2185 pobj loss,as
R1541 T2188 T2187 prep of,loss
R1542 T2189 T2188 pobj function,of
R1543 T2190 T2187 prep for,loss
R1544 T2191 T2190 pobj Tbx15,for
R1545 T2192 T2191 punct ", ",Tbx15
R1546 T2193 T2194 dep which,encodes
R1547 T2194 T2191 relcl encodes,Tbx15
R1548 T2195 T2196 det a,factor
R1549 T2196 T2194 dobj factor,encodes
R1550 T2197 T2198 compound T,box
R1551 T2198 T2196 compound box,factor
R1552 T2199 T2198 punct -,box
R1553 T2200 T2196 compound transcription,factor
R1554 T2201 T2196 acl expressed,factor
R1555 T2202 T2201 prep in,expressed