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PMC:314463 / 46456-47545 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T9663 0-2 IN denotes In
T9665 3-12 JJ denotes embryonic
T9666 13-23 NN denotes mesenchyme
T9667 23-25 , denotes ,
T9668 25-35 NN denotes expression
T9669 36-38 IN denotes of
T9670 39-44 NN denotes Tbx15
T9671 45-48 CC denotes and
T9672 49-55 NN denotes Agouti
T9664 56-59 VBP denotes are
T9673 60-73 JJ denotes complementary
T9674 73-75 , denotes ,
T9675 75-78 CC denotes and
T9676 79-81 PRP denotes it
T9677 82-84 VBZ denotes is
T9678 85-93 JJ denotes possible
T9679 94-98 IN denotes that
T9681 99-104 NN denotes Tbx15
T9680 105-109 VBZ denotes acts
T9682 110-118 RB denotes directly
T9683 119-121 TO denotes to
T9684 122-129 VB denotes inhibit
T9685 130-136 NN denotes Agouti
T9686 137-150 NN denotes transcription
T9687 151-153 IN denotes in
T9688 154-166 JJ denotes dorsolateral
T9689 167-177 NN denotes mesenchyme
T9690 177-178 . denotes .
T9691 178-439 sentence denotes However, the ability of Tbx15 to suppress expression of the ventral-specific Agouti isoform in postnatal mice is likely to be indirect, since postnatal expression of Tbx15 occurs broadly along the dorsoventral axis and overlaps extensively with that of Agouti.
T9692 179-186 RB denotes However
T9694 186-188 , denotes ,
T9695 188-191 DT denotes the
T9696 192-199 NN denotes ability
T9697 200-202 IN denotes of
T9698 203-208 NN denotes Tbx15
T9699 209-211 TO denotes to
T9700 212-220 VB denotes suppress
T9701 221-231 NN denotes expression
T9702 232-234 IN denotes of
T9703 235-238 DT denotes the
T9705 239-246 JJ denotes ventral
T9707 246-247 HYPH denotes -
T9706 247-255 JJ denotes specific
T9708 256-262 NN denotes Agouti
T9704 263-270 NN denotes isoform
T9709 271-273 IN denotes in
T9710 274-283 JJ denotes postnatal
T9711 284-288 NNS denotes mice
T9693 289-291 VBZ denotes is
T9712 292-298 JJ denotes likely
T9713 299-301 TO denotes to
T9714 302-304 VB denotes be
T9715 305-313 JJ denotes indirect
T9716 313-315 , denotes ,
T9717 315-320 IN denotes since
T9719 321-330 JJ denotes postnatal
T9720 331-341 NN denotes expression
T9721 342-344 IN denotes of
T9722 345-350 NN denotes Tbx15
T9718 351-357 VBZ denotes occurs
T9723 358-365 RB denotes broadly
T9724 366-371 IN denotes along
T9725 372-375 DT denotes the
T9727 376-388 JJ denotes dorsoventral
T9726 389-393 NN denotes axis
T9728 394-397 CC denotes and
T9729 398-406 VBZ denotes overlaps
T9730 407-418 RB denotes extensively
T9731 419-423 IN denotes with
T9732 424-428 DT denotes that
T9733 429-431 IN denotes of
T9734 432-438 NN denotes Agouti
T9735 438-439 . denotes .
T9736 439-672 sentence denotes In either case, the targets of Tbx15 action in the skin include genes in addition to Agouti, since hair length and melanocyte distribution exhibit a demonstrable, albeit subtle, alteration in animals that carry a null Agouti allele.
T9737 440-442 IN denotes In
T9739 443-449 DT denotes either
T9740 450-454 NN denotes case
T9741 454-456 , denotes ,
T9742 456-459 DT denotes the
T9743 460-467 NNS denotes targets
T9744 468-470 IN denotes of
T9745 471-476 NN denotes Tbx15
T9746 477-483 NN denotes action
T9747 484-486 IN denotes in
T9748 487-490 DT denotes the
T9749 491-495 NN denotes skin
T9738 496-503 VBP denotes include
T9750 504-509 NNS denotes genes
T9751 510-512 IN denotes in
T9752 513-521 NN denotes addition
T9753 522-524 IN denotes to
T9754 525-531 NN denotes Agouti
T9755 531-533 , denotes ,
T9756 533-538 IN denotes since
T9758 539-543 NN denotes hair
T9759 544-550 NN denotes length
T9760 551-554 CC denotes and
T9761 555-565 NN denotes melanocyte
T9762 566-578 NN denotes distribution
T9757 579-586 VBP denotes exhibit
T9763 587-588 DT denotes a
T9765 589-601 JJ denotes demonstrable
T9766 601-603 , denotes ,
T9767 603-609 CC denotes albeit
T9768 610-616 JJ denotes subtle
T9769 616-618 , denotes ,
T9764 618-628 NN denotes alteration
T9770 629-631 IN denotes in
T9771 632-639 NNS denotes animals
T9772 640-644 WDT denotes that
T9773 645-650 VBP denotes carry
T9774 651-652 DT denotes a
T9776 653-657 JJ denotes null
T9777 658-664 NN denotes Agouti
T9775 665-671 NN denotes allele
T9778 671-672 . denotes .
T9779 672-939 sentence denotes One potential target is Alx4, which, like Agouti, is expressed in ventral embryonic mesenchyme, and, when mutated, affects hair-follicle as well as limb and craniofacial development (Qu et al. 1997, 1998; Wu et al. 2000; Wuyts et al. 2000; Mavrogiannis et al. 2001).
T9780 673-676 CD denotes One
T9782 677-686 JJ denotes potential
T9781 687-693 NN denotes target
T9783 694-696 VBZ denotes is
T9784 697-701 NN denotes Alx4
T9785 701-703 , denotes ,
T9786 703-708 WDT denotes which
T9788 708-710 , denotes ,
T9789 710-714 IN denotes like
T9790 715-721 NN denotes Agouti
T9791 721-723 , denotes ,
T9792 723-725 VBZ denotes is
T9787 726-735 VBN denotes expressed
T9793 736-738 IN denotes in
T9794 739-746 JJ denotes ventral
T9796 747-756 JJ denotes embryonic
T9795 757-767 NN denotes mesenchyme
T9797 767-769 , denotes ,
T9798 769-772 CC denotes and
T9799 772-774 , denotes ,
T9800 774-778 WRB denotes when
T9801 779-786 VBN denotes mutated
T9803 786-788 , denotes ,
T9802 788-795 VBZ denotes affects
T9804 796-800 NN denotes hair
T9806 800-801 HYPH denotes -
T9805 801-809 NN denotes follicle
T9808 810-812 RB denotes as
T9810 813-817 RB denotes well
T9809 818-820 IN denotes as
T9811 821-825 NN denotes limb
T9812 826-829 CC denotes and
T9813 830-842 JJ denotes craniofacial
T9807 843-854 NN denotes development
T9814 855-856 -LRB- denotes (
T9815 856-858 NNP denotes Qu
T9816 859-861 FW denotes et
T9817 862-865 FW denotes al.
T9818 866-870 CD denotes 1997
T9819 870-872 , denotes ,
T9820 872-876 CD denotes 1998
T9821 876-877 : denotes ;
T9822 878-880 NNP denotes Wu
T9823 881-883 FW denotes et
T9824 884-887 FW denotes al.
T9825 888-892 CD denotes 2000
T9826 892-893 : denotes ;
T9827 894-899 NNP denotes Wuyts
T9828 900-902 FW denotes et
T9829 903-906 FW denotes al.
T9830 907-911 CD denotes 2000
T9831 911-912 : denotes ;
T9832 913-925 NNP denotes Mavrogiannis
T9833 926-928 FW denotes et
T9834 929-932 FW denotes al.
T9835 933-937 CD denotes 2001
T9836 937-938 -RRB- denotes )
T9837 938-939 . denotes .
T9838 939-1089 sentence denotes However, expression of ventral markers such as Alx4, as well as Alx3 and Msx2, appears to be unaffected at E11.5 in deH/deH embryos (data not shown).
T9839 940-947 RB denotes However
T9841 947-949 , denotes ,
T9842 949-959 NN denotes expression
T9843 960-962 IN denotes of
T9844 963-970 JJ denotes ventral
T9845 971-978 NNS denotes markers
T9846 979-983 JJ denotes such
T9847 984-986 IN denotes as
T9848 987-991 NN denotes Alx4
T9849 991-993 , denotes ,
T9850 993-995 RB denotes as
T9852 996-1000 RB denotes well
T9851 1001-1003 IN denotes as
T9853 1004-1008 NN denotes Alx3
T9854 1009-1012 CC denotes and
T9855 1013-1017 NN denotes Msx2
T9856 1017-1019 , denotes ,
T9840 1019-1026 VBZ denotes appears
T9857 1027-1029 TO denotes to
T9858 1030-1032 VB denotes be
T9859 1033-1043 JJ denotes unaffected
T9860 1044-1046 IN denotes at
T9861 1047-1052 NN denotes E11.5
T9862 1053-1055 IN denotes in
T9863 1056-1059 NN denotes deH
T9865 1059-1060 HYPH denotes /
T9864 1060-1063 NN denotes deH
T9866 1064-1071 NNS denotes embryos
T9867 1072-1073 -LRB- denotes (
T9869 1073-1077 NNS denotes data
T9870 1078-1081 RB denotes not
T9868 1082-1087 VBN denotes shown
T9871 1087-1088 -RRB- denotes )
T9872 1088-1089 . denotes .
R6687 T9663 T9664 prep In,are
R6688 T9665 T9666 amod embryonic,mesenchyme
R6689 T9666 T9663 pobj mesenchyme,In
R6690 T9667 T9664 punct ", ",are
R6691 T9668 T9664 nsubj expression,are
R6692 T9669 T9668 prep of,expression
R6693 T9670 T9669 pobj Tbx15,of
R6694 T9671 T9670 cc and,Tbx15
R6695 T9672 T9670 conj Agouti,Tbx15
R6696 T9673 T9664 acomp complementary,are
R6697 T9674 T9664 punct ", ",are
R6698 T9675 T9664 cc and,are
R6699 T9676 T9677 nsubj it,is
R6700 T9677 T9664 conj is,are
R6701 T9678 T9677 acomp possible,is
R6702 T9679 T9680 mark that,acts
R6703 T9680 T9677 ccomp acts,is
R6704 T9681 T9680 nsubj Tbx15,acts
R6705 T9682 T9680 advmod directly,acts
R6706 T9683 T9684 aux to,inhibit
R6707 T9684 T9680 advcl inhibit,acts
R6708 T9685 T9686 compound Agouti,transcription
R6709 T9686 T9684 dobj transcription,inhibit
R6710 T9687 T9684 prep in,inhibit
R6711 T9688 T9689 amod dorsolateral,mesenchyme
R6712 T9689 T9687 pobj mesenchyme,in
R6713 T9690 T9664 punct .,are
R6714 T9692 T9693 advmod However,is
R6715 T9694 T9693 punct ", ",is
R6716 T9695 T9696 det the,ability
R6717 T9696 T9693 nsubj ability,is
R6718 T9697 T9696 prep of,ability
R6719 T9698 T9697 pobj Tbx15,of
R6720 T9699 T9700 aux to,suppress
R6721 T9700 T9696 acl suppress,ability
R6722 T9701 T9700 dobj expression,suppress
R6723 T9702 T9701 prep of,expression
R6724 T9703 T9704 det the,isoform
R6725 T9704 T9702 pobj isoform,of
R6726 T9705 T9706 amod ventral,specific
R6727 T9706 T9704 amod specific,isoform
R6728 T9707 T9706 punct -,specific
R6729 T9708 T9704 compound Agouti,isoform
R6730 T9709 T9700 prep in,suppress
R6731 T9710 T9711 amod postnatal,mice
R6732 T9711 T9709 pobj mice,in
R6733 T9712 T9693 acomp likely,is
R6734 T9713 T9714 aux to,be
R6735 T9714 T9712 xcomp be,likely
R6736 T9715 T9714 acomp indirect,be
R6737 T9716 T9693 punct ", ",is
R6738 T9717 T9718 mark since,occurs
R6739 T9718 T9693 advcl occurs,is
R6740 T9719 T9720 amod postnatal,expression
R6741 T9720 T9718 nsubj expression,occurs
R6742 T9721 T9720 prep of,expression
R6743 T9722 T9721 pobj Tbx15,of
R6744 T9723 T9718 advmod broadly,occurs
R6745 T9724 T9718 prep along,occurs
R6746 T9725 T9726 det the,axis
R6747 T9726 T9724 pobj axis,along
R6748 T9727 T9726 amod dorsoventral,axis
R6749 T9728 T9718 cc and,occurs
R6750 T9729 T9718 conj overlaps,occurs
R6751 T9730 T9729 advmod extensively,overlaps
R6752 T9731 T9729 prep with,overlaps
R6753 T9732 T9731 pobj that,with
R6754 T9733 T9732 prep of,that
R6755 T9734 T9733 pobj Agouti,of
R6756 T9735 T9693 punct .,is
R6757 T9737 T9738 prep In,include
R6758 T9739 T9740 det either,case
R6759 T9740 T9737 pobj case,In
R6760 T9741 T9738 punct ", ",include
R6761 T9742 T9743 det the,targets
R6762 T9743 T9738 nsubj targets,include
R6763 T9744 T9743 prep of,targets
R6764 T9745 T9746 compound Tbx15,action
R6765 T9746 T9744 pobj action,of
R6766 T9747 T9743 prep in,targets
R6767 T9748 T9749 det the,skin
R6768 T9749 T9747 pobj skin,in
R6769 T9750 T9738 dobj genes,include
R6770 T9751 T9738 prep in,include
R6771 T9752 T9751 pobj addition,in
R6772 T9753 T9752 prep to,addition
R6773 T9754 T9753 pobj Agouti,to
R6774 T9755 T9738 punct ", ",include
R6775 T9756 T9757 mark since,exhibit
R6776 T9757 T9738 advcl exhibit,include
R6777 T9758 T9759 compound hair,length
R6778 T9759 T9757 nsubj length,exhibit
R6779 T9760 T9759 cc and,length
R6780 T9761 T9762 compound melanocyte,distribution
R6781 T9762 T9759 conj distribution,length
R6782 T9763 T9764 det a,alteration
R6783 T9764 T9757 dobj alteration,exhibit
R6784 T9765 T9764 amod demonstrable,alteration
R6785 T9766 T9765 punct ", ",demonstrable
R6786 T9767 T9765 cc albeit,demonstrable
R6787 T9768 T9765 conj subtle,demonstrable
R6788 T9769 T9764 punct ", ",alteration
R6789 T9770 T9757 prep in,exhibit
R6790 T9771 T9770 pobj animals,in
R6791 T9772 T9773 dep that,carry
R6792 T9773 T9771 relcl carry,animals
R6793 T9774 T9775 det a,allele
R6794 T9775 T9773 dobj allele,carry
R6795 T9776 T9775 amod null,allele
R6796 T9777 T9775 compound Agouti,allele
R6797 T9778 T9738 punct .,include
R6798 T9780 T9781 nummod One,target
R6799 T9781 T9783 nsubj target,is
R6800 T9782 T9781 amod potential,target
R6801 T9784 T9783 attr Alx4,is
R6802 T9785 T9784 punct ", ",Alx4
R6803 T9786 T9787 dep which,expressed
R6804 T9787 T9784 relcl expressed,Alx4
R6805 T9788 T9787 punct ", ",expressed
R6806 T9789 T9787 prep like,expressed
R6807 T9790 T9789 pobj Agouti,like
R6808 T9791 T9787 punct ", ",expressed
R6809 T9792 T9787 auxpass is,expressed
R6810 T9793 T9787 prep in,expressed
R6811 T9794 T9795 amod ventral,mesenchyme
R6812 T9795 T9793 pobj mesenchyme,in
R6813 T9796 T9795 amod embryonic,mesenchyme
R6814 T9797 T9787 punct ", ",expressed
R6815 T9798 T9787 cc and,expressed
R6816 T9799 T9787 punct ", ",expressed
R6817 T9800 T9801 advmod when,mutated
R6818 T9801 T9802 advcl mutated,affects
R6819 T9802 T9787 conj affects,expressed
R6820 T9803 T9802 punct ", ",affects
R6821 T9804 T9805 nmod hair,follicle
R6822 T9805 T9807 nmod follicle,development
R6823 T9806 T9805 punct -,follicle
R6824 T9807 T9802 dobj development,affects
R6825 T9808 T9809 advmod as,as
R6826 T9809 T9805 cc as,follicle
R6827 T9810 T9809 advmod well,as
R6828 T9811 T9805 conj limb,follicle
R6829 T9812 T9811 cc and,limb
R6830 T9813 T9811 conj craniofacial,limb
R6831 T9814 T9815 punct (,Qu
R6832 T9815 T9783 meta Qu,is
R6833 T9816 T9815 nmod et,Qu
R6834 T9817 T9815 nmod al.,Qu
R6835 T9818 T9815 nummod 1997,Qu
R6836 T9819 T9815 punct ", ",Qu
R6837 T9820 T9815 nummod 1998,Qu
R6838 T9821 T9815 punct ;,Qu
R6839 T9822 T9815 nmod Wu,Qu
R6840 T9823 T9815 nmod et,Qu
R6841 T9824 T9815 nmod al.,Qu
R6842 T9825 T9815 nummod 2000,Qu
R6843 T9826 T9815 punct ;,Qu
R6844 T9827 T9815 nmod Wuyts,Qu
R6845 T9828 T9815 nmod et,Qu
R6846 T9829 T9815 nmod al.,Qu
R6847 T9830 T9815 nummod 2000,Qu
R6848 T9831 T9815 punct ;,Qu
R6849 T9832 T9815 nmod Mavrogiannis,Qu
R6850 T9833 T9815 nmod et,Qu
R6851 T9834 T9815 nmod al.,Qu
R6852 T9835 T9815 nummod 2001,Qu
R6853 T9836 T9815 punct ),Qu
R6854 T9837 T9783 punct .,is
R6855 T9839 T9840 advmod However,appears
R6856 T9841 T9840 punct ", ",appears
R6857 T9842 T9840 nsubj expression,appears
R6858 T9843 T9842 prep of,expression
R6859 T9844 T9845 amod ventral,markers
R6860 T9845 T9843 pobj markers,of
R6861 T9846 T9847 amod such,as
R6862 T9847 T9845 prep as,markers
R6863 T9848 T9847 pobj Alx4,as
R6864 T9849 T9848 punct ", ",Alx4
R6865 T9850 T9851 advmod as,as
R6866 T9851 T9848 cc as,Alx4
R6867 T9852 T9851 advmod well,as
R6868 T9853 T9848 conj Alx3,Alx4
R6869 T9854 T9853 cc and,Alx3
R6870 T9855 T9853 conj Msx2,Alx3
R6871 T9856 T9840 punct ", ",appears
R6872 T9857 T9858 aux to,be
R6873 T9858 T9840 xcomp be,appears
R6874 T9859 T9858 acomp unaffected,be
R6875 T9860 T9858 prep at,be
R6876 T9861 T9860 pobj E11.5,at
R6877 T9862 T9858 prep in,be
R6878 T9863 T9864 compound deH,deH
R6879 T9864 T9866 compound deH,embryos
R6880 T9865 T9864 punct /,deH
R6881 T9866 T9862 pobj embryos,in
R6882 T9867 T9868 punct (,shown
R6883 T9868 T9858 parataxis shown,be
R6884 T9869 T9868 nsubj data,shown
R6885 T9870 T9868 neg not,shown
R6886 T9871 T9868 punct ),shown
R6887 T9872 T9840 punct .,appears