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PMC:314463 / 44802-47545 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T9366 0-13 JJ denotes Developmental
T9367 14-23 NN denotes Mechanism
T9368 24-26 IN denotes of
T9369 27-32 NN denotes Tbx15
T9370 33-43 NN denotes Expression
T9371 44-47 CC denotes and
T9372 48-54 NN denotes Action
T9373 55-57 IN denotes in
T9374 58-61 DT denotes the
T9375 62-66 NN denotes Skin
T9376 66-184 sentence denotes Our attention to the role of Tbx15 in pigment patterning was motivated by the effects of Agouti in postnatal animals.
T9377 67-70 PRP$ denotes Our
T9378 71-80 NN denotes attention
T9380 81-83 IN denotes to
T9381 84-87 DT denotes the
T9382 88-92 NN denotes role
T9383 93-95 IN denotes of
T9384 96-101 NN denotes Tbx15
T9385 102-104 IN denotes in
T9386 105-112 NN denotes pigment
T9387 113-123 NN denotes patterning
T9388 124-127 VBD denotes was
T9379 128-137 VBN denotes motivated
T9389 138-140 IN denotes by
T9390 141-144 DT denotes the
T9391 145-152 NNS denotes effects
T9392 153-155 IN denotes of
T9393 156-162 NN denotes Agouti
T9394 163-165 IN denotes in
T9395 166-175 JJ denotes postnatal
T9396 176-183 NNS denotes animals
T9397 183-184 . denotes .
T9398 184-299 sentence denotes However, Agouti is also expressed in the embryo, where it provides a convenient marker of ventral dermis identity.
T9399 185-192 RB denotes However
T9401 192-194 , denotes ,
T9402 194-200 NN denotes Agouti
T9403 201-203 VBZ denotes is
T9404 204-208 RB denotes also
T9400 209-218 VBN denotes expressed
T9405 219-221 IN denotes in
T9406 222-225 DT denotes the
T9407 226-232 NN denotes embryo
T9408 232-234 , denotes ,
T9409 234-239 WRB denotes where
T9411 240-242 PRP denotes it
T9410 243-251 VBZ denotes provides
T9412 252-253 DT denotes a
T9414 254-264 JJ denotes convenient
T9413 265-271 NN denotes marker
T9415 272-274 IN denotes of
T9416 275-282 JJ denotes ventral
T9418 283-289 NN denotes dermis
T9417 290-298 NN denotes identity
T9419 298-299 . denotes .
T9420 299-479 sentence denotes Because an expanded domain of embryonic Agouti expression in deH/deH animals is detectable by E14.5, the effects of Tbx15 on dorsoventral patterning must occur prior to this time.
T9421 300-307 IN denotes Because
T9423 308-310 DT denotes an
T9425 311-319 VBN denotes expanded
T9424 320-326 NN denotes domain
T9426 327-329 IN denotes of
T9427 330-339 JJ denotes embryonic
T9429 340-346 NN denotes Agouti
T9428 347-357 NN denotes expression
T9430 358-360 IN denotes in
T9431 361-364 NN denotes deH
T9433 364-365 HYPH denotes /
T9432 365-368 NN denotes deH
T9434 369-376 NNS denotes animals
T9422 377-379 VBZ denotes is
T9436 380-390 JJ denotes detectable
T9437 391-393 IN denotes by
T9438 394-399 NN denotes E14.5
T9439 399-401 , denotes ,
T9440 401-404 DT denotes the
T9441 405-412 NNS denotes effects
T9442 413-415 IN denotes of
T9443 416-421 NN denotes Tbx15
T9444 422-424 IN denotes on
T9445 425-437 JJ denotes dorsoventral
T9446 438-448 NN denotes patterning
T9447 449-453 MD denotes must
T9435 454-459 VB denotes occur
T9448 460-465 RB denotes prior
T9449 466-468 IN denotes to
T9450 469-473 DT denotes this
T9451 474-478 NN denotes time
T9452 478-479 . denotes .
T9453 479-863 sentence denotes Among other T-box genes whose developmental actions are at least partially understood, two general themes have emerged, one focused on the ability to specify alternative fates for an undifferentiated group of precursor cells and another focused on the ability to support proliferative expansion of a cell population whose fate is already determined (reviewed in Tada and Smith 2001).
T9454 480-485 IN denotes Among
T9456 486-491 JJ denotes other
T9458 492-493 NN denotes T
T9460 493-494 HYPH denotes -
T9459 494-497 NN denotes box
T9457 498-503 NNS denotes genes
T9461 504-509 WP$ denotes whose
T9463 510-523 JJ denotes developmental
T9462 524-531 NNS denotes actions
T9465 532-535 VBP denotes are
T9466 536-538 RB denotes at
T9467 539-544 RBS denotes least
T9468 545-554 RB denotes partially
T9464 555-565 VBN denotes understood
T9469 565-567 , denotes ,
T9470 567-570 CD denotes two
T9472 571-578 JJ denotes general
T9471 579-585 NNS denotes themes
T9473 586-590 VBP denotes have
T9455 591-598 VBN denotes emerged
T9474 598-600 , denotes ,
T9475 600-603 CD denotes one
T9476 604-611 VBD denotes focused
T9477 612-614 IN denotes on
T9478 615-618 DT denotes the
T9479 619-626 NN denotes ability
T9480 627-629 TO denotes to
T9481 630-637 VB denotes specify
T9482 638-649 JJ denotes alternative
T9483 650-655 NNS denotes fates
T9484 656-659 IN denotes for
T9485 660-662 DT denotes an
T9487 663-679 JJ denotes undifferentiated
T9486 680-685 NN denotes group
T9488 686-688 IN denotes of
T9489 689-698 NN denotes precursor
T9490 699-704 NNS denotes cells
T9491 705-708 CC denotes and
T9492 709-716 DT denotes another
T9493 717-724 VBD denotes focused
T9494 725-727 IN denotes on
T9495 728-731 DT denotes the
T9496 732-739 NN denotes ability
T9497 740-742 TO denotes to
T9498 743-750 VB denotes support
T9499 751-764 JJ denotes proliferative
T9500 765-774 NN denotes expansion
T9501 775-777 IN denotes of
T9502 778-779 DT denotes a
T9504 780-784 NN denotes cell
T9503 785-795 NN denotes population
T9505 796-801 WP$ denotes whose
T9506 802-806 NN denotes fate
T9508 807-809 VBZ denotes is
T9509 810-817 RB denotes already
T9507 818-828 VBN denotes determined
T9510 829-830 -LRB- denotes (
T9511 830-838 VBN denotes reviewed
T9512 839-841 IN denotes in
T9513 842-846 NNP denotes Tada
T9514 847-850 CC denotes and
T9515 851-856 NNP denotes Smith
T9516 857-861 CD denotes 2001
T9517 861-862 -RRB- denotes )
T9518 862-863 . denotes .
T9519 863-956 sentence denotes Either mechanism may apply to the apparent dorsal-to-ventral transformation in deH/deH mice.
T9520 864-870 DT denotes Either
T9521 871-880 NN denotes mechanism
T9523 881-884 MD denotes may
T9522 885-890 VB denotes apply
T9524 891-893 IN denotes to
T9525 894-897 DT denotes the
T9527 898-906 JJ denotes apparent
T9528 907-913 JJ denotes dorsal
T9529 913-914 HYPH denotes -
T9530 914-916 IN denotes to
T9531 916-917 HYPH denotes -
T9532 917-924 JJ denotes ventral
T9526 925-939 NN denotes transformation
T9533 940-942 IN denotes in
T9534 943-946 NN denotes deH
T9536 946-947 HYPH denotes /
T9535 947-950 NN denotes deH
T9537 951-955 NNS denotes mice
T9538 955-956 . denotes .
T9539 956-1330 sentence denotes For example, while the expanded domain of Agouti expression in postnatal deH/deH animals can be traced to events that occur between E11.5 and E13.5, the underlying cause may be that embryonic cells in dorsolateral mesenchyme acquire a ventral rather than dorsal identity or that those cells fail to proliferate normally, followed by compensatory expansion of ventral cells.
T9540 957-960 IN denotes For
T9542 961-968 NN denotes example
T9543 968-970 , denotes ,
T9544 970-975 IN denotes while
T9546 976-979 DT denotes the
T9548 980-988 VBN denotes expanded
T9547 989-995 NN denotes domain
T9549 996-998 IN denotes of
T9550 999-1005 NN denotes Agouti
T9551 1006-1016 NN denotes expression
T9552 1017-1019 IN denotes in
T9553 1020-1029 JJ denotes postnatal
T9555 1030-1033 NN denotes deH
T9557 1033-1034 HYPH denotes /
T9556 1034-1037 NN denotes deH
T9554 1038-1045 NNS denotes animals
T9558 1046-1049 MD denotes can
T9559 1050-1052 VB denotes be
T9545 1053-1059 VBN denotes traced
T9560 1060-1062 IN denotes to
T9561 1063-1069 NNS denotes events
T9562 1070-1074 WDT denotes that
T9563 1075-1080 VBP denotes occur
T9564 1081-1088 IN denotes between
T9565 1089-1094 NN denotes E11.5
T9566 1095-1098 CC denotes and
T9567 1099-1104 NN denotes E13.5
T9568 1104-1106 , denotes ,
T9569 1106-1109 DT denotes the
T9571 1110-1120 JJ denotes underlying
T9570 1121-1126 NN denotes cause
T9572 1127-1130 MD denotes may
T9541 1131-1133 VB denotes be
T9573 1134-1138 IN denotes that
T9575 1139-1148 JJ denotes embryonic
T9576 1149-1154 NNS denotes cells
T9577 1155-1157 IN denotes in
T9578 1158-1170 JJ denotes dorsolateral
T9579 1171-1181 NN denotes mesenchyme
T9574 1182-1189 VBP denotes acquire
T9580 1190-1191 DT denotes a
T9582 1192-1199 JJ denotes ventral
T9583 1200-1206 IN denotes rather
T9584 1207-1211 IN denotes than
T9585 1212-1218 JJ denotes dorsal
T9581 1219-1227 NN denotes identity
T9586 1228-1230 CC denotes or
T9587 1231-1235 IN denotes that
T9589 1236-1241 DT denotes those
T9590 1242-1247 NNS denotes cells
T9588 1248-1252 VBP denotes fail
T9591 1253-1255 TO denotes to
T9592 1256-1267 VB denotes proliferate
T9593 1268-1276 RB denotes normally
T9594 1276-1278 , denotes ,
T9595 1278-1286 VBN denotes followed
T9596 1287-1289 IN denotes by
T9597 1290-1302 JJ denotes compensatory
T9598 1303-1312 NN denotes expansion
T9599 1313-1315 IN denotes of
T9600 1316-1323 JJ denotes ventral
T9601 1324-1329 NNS denotes cells
T9602 1329-1330 . denotes .
T9603 1330-1653 sentence denotes Cell lineage studies should provide a definitive answer, but we favor the latter hypothesis, because measurements of dorsoventral regions according to hair color in deH/deH mice revealed a small increase of the cream-colored ventral region in addition to the approximate doubling of the yellow flank region (see Figure 2).
T9604 1331-1335 NN denotes Cell
T9605 1336-1343 NN denotes lineage
T9606 1344-1351 NNS denotes studies
T9608 1352-1358 MD denotes should
T9607 1359-1366 VB denotes provide
T9609 1367-1368 DT denotes a
T9611 1369-1379 JJ denotes definitive
T9610 1380-1386 NN denotes answer
T9612 1386-1388 , denotes ,
T9613 1388-1391 CC denotes but
T9614 1392-1394 PRP denotes we
T9615 1395-1400 VBP denotes favor
T9616 1401-1404 DT denotes the
T9618 1405-1411 JJ denotes latter
T9617 1412-1422 NN denotes hypothesis
T9619 1422-1424 , denotes ,
T9620 1424-1431 IN denotes because
T9622 1432-1444 NNS denotes measurements
T9623 1445-1447 IN denotes of
T9624 1448-1460 JJ denotes dorsoventral
T9625 1461-1468 NNS denotes regions
T9626 1469-1478 VBG denotes according
T9627 1479-1481 IN denotes to
T9628 1482-1486 NN denotes hair
T9629 1487-1492 NN denotes color
T9630 1493-1495 IN denotes in
T9631 1496-1499 NN denotes deH
T9633 1499-1500 HYPH denotes /
T9632 1500-1503 NN denotes deH
T9634 1504-1508 NNS denotes mice
T9621 1509-1517 VBD denotes revealed
T9635 1518-1519 DT denotes a
T9637 1520-1525 JJ denotes small
T9636 1526-1534 NN denotes increase
T9638 1535-1537 IN denotes of
T9639 1538-1541 DT denotes the
T9641 1542-1547 JJ denotes cream
T9643 1547-1548 HYPH denotes -
T9642 1548-1555 JJ denotes colored
T9644 1556-1563 JJ denotes ventral
T9640 1564-1570 NN denotes region
T9645 1571-1573 IN denotes in
T9646 1574-1582 NN denotes addition
T9647 1583-1585 IN denotes to
T9648 1586-1589 DT denotes the
T9650 1590-1601 JJ denotes approximate
T9649 1602-1610 NN denotes doubling
T9651 1611-1613 IN denotes of
T9652 1614-1617 DT denotes the
T9654 1618-1624 JJ denotes yellow
T9655 1625-1630 NN denotes flank
T9653 1631-1637 NN denotes region
T9656 1638-1639 -LRB- denotes (
T9657 1639-1642 VB denotes see
T9658 1643-1649 NN denotes Figure
T9659 1650-1651 CD denotes 2
T9660 1651-1652 -RRB- denotes )
T9661 1652-1653 . denotes .
T9662 1653-1832 sentence denotes In embryonic mesenchyme, expression of Tbx15 and Agouti are complementary, and it is possible that Tbx15 acts directly to inhibit Agouti transcription in dorsolateral mesenchyme.
T9663 1654-1656 IN denotes In
T9665 1657-1666 JJ denotes embryonic
T9666 1667-1677 NN denotes mesenchyme
T9667 1677-1679 , denotes ,
T9668 1679-1689 NN denotes expression
T9669 1690-1692 IN denotes of
T9670 1693-1698 NN denotes Tbx15
T9671 1699-1702 CC denotes and
T9672 1703-1709 NN denotes Agouti
T9664 1710-1713 VBP denotes are
T9673 1714-1727 JJ denotes complementary
T9674 1727-1729 , denotes ,
T9675 1729-1732 CC denotes and
T9676 1733-1735 PRP denotes it
T9677 1736-1738 VBZ denotes is
T9678 1739-1747 JJ denotes possible
T9679 1748-1752 IN denotes that
T9681 1753-1758 NN denotes Tbx15
T9680 1759-1763 VBZ denotes acts
T9682 1764-1772 RB denotes directly
T9683 1773-1775 TO denotes to
T9684 1776-1783 VB denotes inhibit
T9685 1784-1790 NN denotes Agouti
T9686 1791-1804 NN denotes transcription
T9687 1805-1807 IN denotes in
T9688 1808-1820 JJ denotes dorsolateral
T9689 1821-1831 NN denotes mesenchyme
T9690 1831-1832 . denotes .
T9691 1832-2093 sentence denotes However, the ability of Tbx15 to suppress expression of the ventral-specific Agouti isoform in postnatal mice is likely to be indirect, since postnatal expression of Tbx15 occurs broadly along the dorsoventral axis and overlaps extensively with that of Agouti.
T9692 1833-1840 RB denotes However
T9694 1840-1842 , denotes ,
T9695 1842-1845 DT denotes the
T9696 1846-1853 NN denotes ability
T9697 1854-1856 IN denotes of
T9698 1857-1862 NN denotes Tbx15
T9699 1863-1865 TO denotes to
T9700 1866-1874 VB denotes suppress
T9701 1875-1885 NN denotes expression
T9702 1886-1888 IN denotes of
T9703 1889-1892 DT denotes the
T9705 1893-1900 JJ denotes ventral
T9707 1900-1901 HYPH denotes -
T9706 1901-1909 JJ denotes specific
T9708 1910-1916 NN denotes Agouti
T9704 1917-1924 NN denotes isoform
T9709 1925-1927 IN denotes in
T9710 1928-1937 JJ denotes postnatal
T9711 1938-1942 NNS denotes mice
T9693 1943-1945 VBZ denotes is
T9712 1946-1952 JJ denotes likely
T9713 1953-1955 TO denotes to
T9714 1956-1958 VB denotes be
T9715 1959-1967 JJ denotes indirect
T9716 1967-1969 , denotes ,
T9717 1969-1974 IN denotes since
T9719 1975-1984 JJ denotes postnatal
T9720 1985-1995 NN denotes expression
T9721 1996-1998 IN denotes of
T9722 1999-2004 NN denotes Tbx15
T9718 2005-2011 VBZ denotes occurs
T9723 2012-2019 RB denotes broadly
T9724 2020-2025 IN denotes along
T9725 2026-2029 DT denotes the
T9727 2030-2042 JJ denotes dorsoventral
T9726 2043-2047 NN denotes axis
T9728 2048-2051 CC denotes and
T9729 2052-2060 VBZ denotes overlaps
T9730 2061-2072 RB denotes extensively
T9731 2073-2077 IN denotes with
T9732 2078-2082 DT denotes that
T9733 2083-2085 IN denotes of
T9734 2086-2092 NN denotes Agouti
T9735 2092-2093 . denotes .
T9736 2093-2326 sentence denotes In either case, the targets of Tbx15 action in the skin include genes in addition to Agouti, since hair length and melanocyte distribution exhibit a demonstrable, albeit subtle, alteration in animals that carry a null Agouti allele.
T9737 2094-2096 IN denotes In
T9739 2097-2103 DT denotes either
T9740 2104-2108 NN denotes case
T9741 2108-2110 , denotes ,
T9742 2110-2113 DT denotes the
T9743 2114-2121 NNS denotes targets
T9744 2122-2124 IN denotes of
T9745 2125-2130 NN denotes Tbx15
T9746 2131-2137 NN denotes action
T9747 2138-2140 IN denotes in
T9748 2141-2144 DT denotes the
T9749 2145-2149 NN denotes skin
T9738 2150-2157 VBP denotes include
T9750 2158-2163 NNS denotes genes
T9751 2164-2166 IN denotes in
T9752 2167-2175 NN denotes addition
T9753 2176-2178 IN denotes to
T9754 2179-2185 NN denotes Agouti
T9755 2185-2187 , denotes ,
T9756 2187-2192 IN denotes since
T9758 2193-2197 NN denotes hair
T9759 2198-2204 NN denotes length
T9760 2205-2208 CC denotes and
T9761 2209-2219 NN denotes melanocyte
T9762 2220-2232 NN denotes distribution
T9757 2233-2240 VBP denotes exhibit
T9763 2241-2242 DT denotes a
T9765 2243-2255 JJ denotes demonstrable
T9766 2255-2257 , denotes ,
T9767 2257-2263 CC denotes albeit
T9768 2264-2270 JJ denotes subtle
T9769 2270-2272 , denotes ,
T9764 2272-2282 NN denotes alteration
T9770 2283-2285 IN denotes in
T9771 2286-2293 NNS denotes animals
T9772 2294-2298 WDT denotes that
T9773 2299-2304 VBP denotes carry
T9774 2305-2306 DT denotes a
T9776 2307-2311 JJ denotes null
T9777 2312-2318 NN denotes Agouti
T9775 2319-2325 NN denotes allele
T9778 2325-2326 . denotes .
T9779 2326-2593 sentence denotes One potential target is Alx4, which, like Agouti, is expressed in ventral embryonic mesenchyme, and, when mutated, affects hair-follicle as well as limb and craniofacial development (Qu et al. 1997, 1998; Wu et al. 2000; Wuyts et al. 2000; Mavrogiannis et al. 2001).
T9780 2327-2330 CD denotes One
T9782 2331-2340 JJ denotes potential
T9781 2341-2347 NN denotes target
T9783 2348-2350 VBZ denotes is
T9784 2351-2355 NN denotes Alx4
T9785 2355-2357 , denotes ,
T9786 2357-2362 WDT denotes which
T9788 2362-2364 , denotes ,
T9789 2364-2368 IN denotes like
T9790 2369-2375 NN denotes Agouti
T9791 2375-2377 , denotes ,
T9792 2377-2379 VBZ denotes is
T9787 2380-2389 VBN denotes expressed
T9793 2390-2392 IN denotes in
T9794 2393-2400 JJ denotes ventral
T9796 2401-2410 JJ denotes embryonic
T9795 2411-2421 NN denotes mesenchyme
T9797 2421-2423 , denotes ,
T9798 2423-2426 CC denotes and
T9799 2426-2428 , denotes ,
T9800 2428-2432 WRB denotes when
T9801 2433-2440 VBN denotes mutated
T9803 2440-2442 , denotes ,
T9802 2442-2449 VBZ denotes affects
T9804 2450-2454 NN denotes hair
T9806 2454-2455 HYPH denotes -
T9805 2455-2463 NN denotes follicle
T9808 2464-2466 RB denotes as
T9810 2467-2471 RB denotes well
T9809 2472-2474 IN denotes as
T9811 2475-2479 NN denotes limb
T9812 2480-2483 CC denotes and
T9813 2484-2496 JJ denotes craniofacial
T9807 2497-2508 NN denotes development
T9814 2509-2510 -LRB- denotes (
T9815 2510-2512 NNP denotes Qu
T9816 2513-2515 FW denotes et
T9817 2516-2519 FW denotes al.
T9818 2520-2524 CD denotes 1997
T9819 2524-2526 , denotes ,
T9820 2526-2530 CD denotes 1998
T9821 2530-2531 : denotes ;
T9822 2532-2534 NNP denotes Wu
T9823 2535-2537 FW denotes et
T9824 2538-2541 FW denotes al.
T9825 2542-2546 CD denotes 2000
T9826 2546-2547 : denotes ;
T9827 2548-2553 NNP denotes Wuyts
T9828 2554-2556 FW denotes et
T9829 2557-2560 FW denotes al.
T9830 2561-2565 CD denotes 2000
T9831 2565-2566 : denotes ;
T9832 2567-2579 NNP denotes Mavrogiannis
T9833 2580-2582 FW denotes et
T9834 2583-2586 FW denotes al.
T9835 2587-2591 CD denotes 2001
T9836 2591-2592 -RRB- denotes )
T9837 2592-2593 . denotes .
T9838 2593-2743 sentence denotes However, expression of ventral markers such as Alx4, as well as Alx3 and Msx2, appears to be unaffected at E11.5 in deH/deH embryos (data not shown).
T9839 2594-2601 RB denotes However
T9841 2601-2603 , denotes ,
T9842 2603-2613 NN denotes expression
T9843 2614-2616 IN denotes of
T9844 2617-2624 JJ denotes ventral
T9845 2625-2632 NNS denotes markers
T9846 2633-2637 JJ denotes such
T9847 2638-2640 IN denotes as
T9848 2641-2645 NN denotes Alx4
T9849 2645-2647 , denotes ,
T9850 2647-2649 RB denotes as
T9852 2650-2654 RB denotes well
T9851 2655-2657 IN denotes as
T9853 2658-2662 NN denotes Alx3
T9854 2663-2666 CC denotes and
T9855 2667-2671 NN denotes Msx2
T9856 2671-2673 , denotes ,
T9840 2673-2680 VBZ denotes appears
T9857 2681-2683 TO denotes to
T9858 2684-2686 VB denotes be
T9859 2687-2697 JJ denotes unaffected
T9860 2698-2700 IN denotes at
T9861 2701-2706 NN denotes E11.5
T9862 2707-2709 IN denotes in
T9863 2710-2713 NN denotes deH
T9865 2713-2714 HYPH denotes /
T9864 2714-2717 NN denotes deH
T9866 2718-2725 NNS denotes embryos
T9867 2726-2727 -LRB- denotes (
T9869 2727-2731 NNS denotes data
T9870 2732-2735 RB denotes not
T9868 2736-2741 VBN denotes shown
T9871 2741-2742 -RRB- denotes )
T9872 2742-2743 . denotes .
R6406 T9366 T9367 amod Developmental,Mechanism
R6407 T9368 T9367 prep of,Mechanism
R6408 T9369 T9370 compound Tbx15,Expression
R6409 T9370 T9368 pobj Expression,of
R6410 T9371 T9370 cc and,Expression
R6411 T9372 T9370 conj Action,Expression
R6412 T9373 T9370 prep in,Expression
R6413 T9374 T9375 det the,Skin
R6414 T9375 T9373 pobj Skin,in
R6415 T9377 T9378 poss Our,attention
R6416 T9378 T9379 nsubjpass attention,motivated
R6417 T9380 T9378 prep to,attention
R6418 T9381 T9382 det the,role
R6419 T9382 T9380 pobj role,to
R6420 T9383 T9382 prep of,role
R6421 T9384 T9383 pobj Tbx15,of
R6422 T9385 T9382 prep in,role
R6423 T9386 T9387 compound pigment,patterning
R6424 T9387 T9385 pobj patterning,in
R6425 T9388 T9379 auxpass was,motivated
R6426 T9389 T9379 agent by,motivated
R6427 T9390 T9391 det the,effects
R6428 T9391 T9389 pobj effects,by
R6429 T9392 T9391 prep of,effects
R6430 T9393 T9392 pobj Agouti,of
R6431 T9394 T9391 prep in,effects
R6432 T9395 T9396 amod postnatal,animals
R6433 T9396 T9394 pobj animals,in
R6434 T9397 T9379 punct .,motivated
R6435 T9399 T9400 advmod However,expressed
R6436 T9401 T9400 punct ", ",expressed
R6437 T9402 T9400 nsubjpass Agouti,expressed
R6438 T9403 T9400 auxpass is,expressed
R6439 T9404 T9400 advmod also,expressed
R6440 T9405 T9400 prep in,expressed
R6441 T9406 T9407 det the,embryo
R6442 T9407 T9405 pobj embryo,in
R6443 T9408 T9407 punct ", ",embryo
R6444 T9409 T9410 advmod where,provides
R6445 T9410 T9407 relcl provides,embryo
R6446 T9411 T9410 nsubj it,provides
R6447 T9412 T9413 det a,marker
R6448 T9413 T9410 dobj marker,provides
R6449 T9414 T9413 amod convenient,marker
R6450 T9415 T9413 prep of,marker
R6451 T9416 T9417 amod ventral,identity
R6452 T9417 T9415 pobj identity,of
R6453 T9418 T9417 compound dermis,identity
R6454 T9419 T9400 punct .,expressed
R6455 T9421 T9422 mark Because,is
R6456 T9422 T9435 advcl is,occur
R6457 T9423 T9424 det an,domain
R6458 T9424 T9422 nsubj domain,is
R6459 T9425 T9424 amod expanded,domain
R6460 T9426 T9424 prep of,domain
R6461 T9427 T9428 amod embryonic,expression
R6462 T9428 T9426 pobj expression,of
R6463 T9429 T9428 compound Agouti,expression
R6464 T9430 T9424 prep in,domain
R6465 T9431 T9432 compound deH,deH
R6466 T9432 T9434 compound deH,animals
R6467 T9433 T9432 punct /,deH
R6468 T9434 T9430 pobj animals,in
R6469 T9436 T9422 acomp detectable,is
R6470 T9437 T9422 prep by,is
R6471 T9438 T9437 pobj E14.5,by
R6472 T9439 T9435 punct ", ",occur
R6473 T9440 T9441 det the,effects
R6474 T9441 T9435 nsubj effects,occur
R6475 T9442 T9441 prep of,effects
R6476 T9443 T9442 pobj Tbx15,of
R6477 T9444 T9441 prep on,effects
R6478 T9445 T9446 amod dorsoventral,patterning
R6479 T9446 T9444 pobj patterning,on
R6480 T9447 T9435 aux must,occur
R6481 T9448 T9435 advmod prior,occur
R6482 T9449 T9448 prep to,prior
R6483 T9450 T9451 det this,time
R6484 T9451 T9449 pobj time,to
R6485 T9452 T9435 punct .,occur
R6486 T9454 T9455 prep Among,emerged
R6487 T9456 T9457 amod other,genes
R6488 T9457 T9454 pobj genes,Among
R6489 T9458 T9459 compound T,box
R6490 T9459 T9457 compound box,genes
R6491 T9460 T9459 punct -,box
R6492 T9461 T9462 poss whose,actions
R6493 T9462 T9464 dep actions,understood
R6494 T9463 T9462 amod developmental,actions
R6495 T9464 T9457 relcl understood,genes
R6496 T9465 T9464 auxpass are,understood
R6497 T9466 T9467 advmod at,least
R6498 T9467 T9468 advmod least,partially
R6499 T9468 T9464 advmod partially,understood
R6500 T9469 T9455 punct ", ",emerged
R6501 T9470 T9471 nummod two,themes
R6502 T9471 T9455 nsubj themes,emerged
R6503 T9472 T9471 amod general,themes
R6504 T9473 T9455 aux have,emerged
R6505 T9474 T9455 punct ", ",emerged
R6506 T9475 T9476 nsubj one,focused
R6507 T9476 T9455 advcl focused,emerged
R6508 T9477 T9476 prep on,focused
R6509 T9478 T9479 det the,ability
R6510 T9479 T9477 pobj ability,on
R6511 T9480 T9481 aux to,specify
R6512 T9481 T9479 acl specify,ability
R6513 T9482 T9483 amod alternative,fates
R6514 T9483 T9481 dobj fates,specify
R6515 T9484 T9481 prep for,specify
R6516 T9485 T9486 det an,group
R6517 T9486 T9484 pobj group,for
R6518 T9487 T9486 amod undifferentiated,group
R6519 T9488 T9486 prep of,group
R6520 T9489 T9490 compound precursor,cells
R6521 T9490 T9488 pobj cells,of
R6522 T9491 T9476 cc and,focused
R6523 T9492 T9493 nsubj another,focused
R6524 T9493 T9476 conj focused,focused
R6525 T9494 T9493 prep on,focused
R6526 T9495 T9496 det the,ability
R6527 T9496 T9494 pobj ability,on
R6528 T9497 T9498 aux to,support
R6529 T9498 T9496 acl support,ability
R6530 T9499 T9500 amod proliferative,expansion
R6531 T9500 T9498 dobj expansion,support
R6532 T9501 T9500 prep of,expansion
R6533 T9502 T9503 det a,population
R6534 T9503 T9501 pobj population,of
R6535 T9504 T9503 compound cell,population
R6536 T9505 T9506 poss whose,fate
R6537 T9506 T9507 dep fate,determined
R6538 T9507 T9503 relcl determined,population
R6539 T9508 T9507 auxpass is,determined
R6540 T9509 T9507 advmod already,determined
R6541 T9510 T9511 punct (,reviewed
R6542 T9511 T9493 parataxis reviewed,focused
R6543 T9512 T9511 prep in,reviewed
R6544 T9513 T9512 pobj Tada,in
R6545 T9514 T9513 cc and,Tada
R6546 T9515 T9513 conj Smith,Tada
R6547 T9516 T9513 npadvmod 2001,Tada
R6548 T9517 T9511 punct ),reviewed
R6549 T9518 T9455 punct .,emerged
R6550 T9520 T9521 det Either,mechanism
R6551 T9521 T9522 nsubj mechanism,apply
R6552 T9523 T9522 aux may,apply
R6553 T9524 T9522 prep to,apply
R6554 T9525 T9526 det the,transformation
R6555 T9526 T9524 pobj transformation,to
R6556 T9527 T9526 amod apparent,transformation
R6557 T9528 T9526 amod dorsal,transformation
R6558 T9529 T9528 punct -,dorsal
R6559 T9530 T9528 prep to,dorsal
R6560 T9531 T9530 punct -,to
R6561 T9532 T9530 amod ventral,to
R6562 T9533 T9526 prep in,transformation
R6563 T9534 T9535 compound deH,deH
R6564 T9535 T9537 compound deH,mice
R6565 T9536 T9535 punct /,deH
R6566 T9537 T9533 pobj mice,in
R6567 T9538 T9522 punct .,apply
R6568 T9540 T9541 prep For,be
R6569 T9542 T9540 pobj example,For
R6570 T9543 T9541 punct ", ",be
R6571 T9544 T9545 mark while,traced
R6572 T9545 T9541 advcl traced,be
R6573 T9546 T9547 det the,domain
R6574 T9547 T9545 nsubjpass domain,traced
R6575 T9548 T9547 amod expanded,domain
R6576 T9549 T9547 prep of,domain
R6577 T9550 T9551 compound Agouti,expression
R6578 T9551 T9549 pobj expression,of
R6579 T9552 T9547 prep in,domain
R6580 T9553 T9554 amod postnatal,animals
R6581 T9554 T9552 pobj animals,in
R6582 T9555 T9556 compound deH,deH
R6583 T9556 T9554 compound deH,animals
R6584 T9557 T9556 punct /,deH
R6585 T9558 T9545 aux can,traced
R6586 T9559 T9545 auxpass be,traced
R6587 T9560 T9545 prep to,traced
R6588 T9561 T9560 pobj events,to
R6589 T9562 T9563 dep that,occur
R6590 T9563 T9561 relcl occur,events
R6591 T9564 T9563 prep between,occur
R6592 T9565 T9564 pobj E11.5,between
R6593 T9566 T9565 cc and,E11.5
R6594 T9567 T9565 conj E13.5,E11.5
R6595 T9568 T9541 punct ", ",be
R6596 T9569 T9570 det the,cause
R6597 T9570 T9541 nsubj cause,be
R6598 T9571 T9570 amod underlying,cause
R6599 T9572 T9541 aux may,be
R6600 T9573 T9574 mark that,acquire
R6601 T9574 T9541 advcl acquire,be
R6602 T9575 T9576 amod embryonic,cells
R6603 T9576 T9574 nsubj cells,acquire
R6604 T9577 T9576 prep in,cells
R6605 T9578 T9579 amod dorsolateral,mesenchyme
R6606 T9579 T9577 pobj mesenchyme,in
R6607 T9580 T9581 det a,identity
R6608 T9581 T9574 dobj identity,acquire
R6609 T9582 T9581 amod ventral,identity
R6610 T9583 T9582 cc rather,ventral
R6611 T9584 T9583 dep than,rather
R6612 T9585 T9582 conj dorsal,ventral
R6613 T9586 T9574 cc or,acquire
R6614 T9587 T9588 mark that,fail
R6615 T9588 T9574 conj fail,acquire
R6616 T9589 T9590 det those,cells
R6617 T9590 T9588 nsubj cells,fail
R6618 T9591 T9592 aux to,proliferate
R6619 T9592 T9588 xcomp proliferate,fail
R6620 T9593 T9592 advmod normally,proliferate
R6621 T9594 T9588 punct ", ",fail
R6622 T9595 T9588 advcl followed,fail
R6623 T9596 T9595 agent by,followed
R6624 T9597 T9598 amod compensatory,expansion
R6625 T9598 T9596 pobj expansion,by
R6626 T9599 T9598 prep of,expansion
R6627 T9600 T9601 amod ventral,cells
R6628 T9601 T9599 pobj cells,of
R6629 T9602 T9541 punct .,be
R6630 T9604 T9605 compound Cell,lineage
R6631 T9605 T9606 compound lineage,studies
R6632 T9606 T9607 nsubj studies,provide
R6633 T9608 T9607 aux should,provide
R6634 T9609 T9610 det a,answer
R6635 T9610 T9607 dobj answer,provide
R6636 T9611 T9610 amod definitive,answer
R6637 T9612 T9607 punct ", ",provide
R6638 T9613 T9607 cc but,provide
R6639 T9614 T9615 nsubj we,favor
R6640 T9615 T9607 conj favor,provide
R6641 T9616 T9617 det the,hypothesis
R6642 T9617 T9615 dobj hypothesis,favor
R6643 T9618 T9617 amod latter,hypothesis
R6644 T9619 T9615 punct ", ",favor
R6645 T9620 T9621 mark because,revealed
R6646 T9621 T9615 advcl revealed,favor
R6647 T9622 T9621 nsubj measurements,revealed
R6648 T9623 T9622 prep of,measurements
R6649 T9624 T9625 amod dorsoventral,regions
R6650 T9625 T9623 pobj regions,of
R6651 T9626 T9622 prep according,measurements
R6652 T9627 T9626 prep to,according
R6653 T9628 T9629 compound hair,color
R6654 T9629 T9627 pobj color,to
R6655 T9630 T9629 prep in,color
R6656 T9631 T9632 compound deH,deH
R6657 T9632 T9634 compound deH,mice
R6658 T9633 T9632 punct /,deH
R6659 T9634 T9630 pobj mice,in
R6660 T9635 T9636 det a,increase
R6661 T9636 T9621 dobj increase,revealed
R6662 T9637 T9636 amod small,increase
R6663 T9638 T9636 prep of,increase
R6664 T9639 T9640 det the,region
R6665 T9640 T9638 pobj region,of
R6666 T9641 T9642 amod cream,colored
R6667 T9642 T9640 amod colored,region
R6668 T9643 T9642 punct -,colored
R6669 T9644 T9640 amod ventral,region
R6670 T9645 T9621 prep in,revealed
R6671 T9646 T9645 pobj addition,in
R6672 T9647 T9646 prep to,addition
R6673 T9648 T9649 det the,doubling
R6674 T9649 T9647 pobj doubling,to
R6675 T9650 T9649 amod approximate,doubling
R6676 T9651 T9649 prep of,doubling
R6677 T9652 T9653 det the,region
R6678 T9653 T9651 pobj region,of
R6679 T9654 T9653 amod yellow,region
R6680 T9655 T9653 compound flank,region
R6681 T9656 T9657 punct (,see
R6682 T9657 T9621 parataxis see,revealed
R6683 T9658 T9657 dobj Figure,see
R6684 T9659 T9658 nummod 2,Figure
R6685 T9660 T9657 punct ),see
R6686 T9661 T9615 punct .,favor
R6687 T9663 T9664 prep In,are
R6688 T9665 T9666 amod embryonic,mesenchyme
R6689 T9666 T9663 pobj mesenchyme,In
R6690 T9667 T9664 punct ", ",are
R6691 T9668 T9664 nsubj expression,are
R6692 T9669 T9668 prep of,expression
R6693 T9670 T9669 pobj Tbx15,of
R6694 T9671 T9670 cc and,Tbx15
R6695 T9672 T9670 conj Agouti,Tbx15
R6696 T9673 T9664 acomp complementary,are
R6697 T9674 T9664 punct ", ",are
R6698 T9675 T9664 cc and,are
R6699 T9676 T9677 nsubj it,is
R6700 T9677 T9664 conj is,are
R6701 T9678 T9677 acomp possible,is
R6702 T9679 T9680 mark that,acts
R6703 T9680 T9677 ccomp acts,is
R6704 T9681 T9680 nsubj Tbx15,acts
R6705 T9682 T9680 advmod directly,acts
R6706 T9683 T9684 aux to,inhibit
R6707 T9684 T9680 advcl inhibit,acts
R6708 T9685 T9686 compound Agouti,transcription
R6709 T9686 T9684 dobj transcription,inhibit
R6710 T9687 T9684 prep in,inhibit
R6711 T9688 T9689 amod dorsolateral,mesenchyme
R6712 T9689 T9687 pobj mesenchyme,in
R6713 T9690 T9664 punct .,are
R6714 T9692 T9693 advmod However,is
R6715 T9694 T9693 punct ", ",is
R6716 T9695 T9696 det the,ability
R6717 T9696 T9693 nsubj ability,is
R6718 T9697 T9696 prep of,ability
R6719 T9698 T9697 pobj Tbx15,of
R6720 T9699 T9700 aux to,suppress
R6721 T9700 T9696 acl suppress,ability
R6722 T9701 T9700 dobj expression,suppress
R6723 T9702 T9701 prep of,expression
R6724 T9703 T9704 det the,isoform
R6725 T9704 T9702 pobj isoform,of
R6726 T9705 T9706 amod ventral,specific
R6727 T9706 T9704 amod specific,isoform
R6728 T9707 T9706 punct -,specific
R6729 T9708 T9704 compound Agouti,isoform
R6730 T9709 T9700 prep in,suppress
R6731 T9710 T9711 amod postnatal,mice
R6732 T9711 T9709 pobj mice,in
R6733 T9712 T9693 acomp likely,is
R6734 T9713 T9714 aux to,be
R6735 T9714 T9712 xcomp be,likely
R6736 T9715 T9714 acomp indirect,be
R6737 T9716 T9693 punct ", ",is
R6738 T9717 T9718 mark since,occurs
R6739 T9718 T9693 advcl occurs,is
R6740 T9719 T9720 amod postnatal,expression
R6741 T9720 T9718 nsubj expression,occurs
R6742 T9721 T9720 prep of,expression
R6743 T9722 T9721 pobj Tbx15,of
R6744 T9723 T9718 advmod broadly,occurs
R6745 T9724 T9718 prep along,occurs
R6746 T9725 T9726 det the,axis
R6747 T9726 T9724 pobj axis,along
R6748 T9727 T9726 amod dorsoventral,axis
R6749 T9728 T9718 cc and,occurs
R6750 T9729 T9718 conj overlaps,occurs
R6751 T9730 T9729 advmod extensively,overlaps
R6752 T9731 T9729 prep with,overlaps
R6753 T9732 T9731 pobj that,with
R6754 T9733 T9732 prep of,that
R6755 T9734 T9733 pobj Agouti,of
R6756 T9735 T9693 punct .,is
R6757 T9737 T9738 prep In,include
R6758 T9739 T9740 det either,case
R6759 T9740 T9737 pobj case,In
R6760 T9741 T9738 punct ", ",include
R6761 T9742 T9743 det the,targets
R6762 T9743 T9738 nsubj targets,include
R6763 T9744 T9743 prep of,targets
R6764 T9745 T9746 compound Tbx15,action
R6765 T9746 T9744 pobj action,of
R6766 T9747 T9743 prep in,targets
R6767 T9748 T9749 det the,skin
R6768 T9749 T9747 pobj skin,in
R6769 T9750 T9738 dobj genes,include
R6770 T9751 T9738 prep in,include
R6771 T9752 T9751 pobj addition,in
R6772 T9753 T9752 prep to,addition
R6773 T9754 T9753 pobj Agouti,to
R6774 T9755 T9738 punct ", ",include
R6775 T9756 T9757 mark since,exhibit
R6776 T9757 T9738 advcl exhibit,include
R6777 T9758 T9759 compound hair,length
R6778 T9759 T9757 nsubj length,exhibit
R6779 T9760 T9759 cc and,length
R6780 T9761 T9762 compound melanocyte,distribution
R6781 T9762 T9759 conj distribution,length
R6782 T9763 T9764 det a,alteration
R6783 T9764 T9757 dobj alteration,exhibit
R6784 T9765 T9764 amod demonstrable,alteration
R6785 T9766 T9765 punct ", ",demonstrable
R6786 T9767 T9765 cc albeit,demonstrable
R6787 T9768 T9765 conj subtle,demonstrable
R6788 T9769 T9764 punct ", ",alteration
R6789 T9770 T9757 prep in,exhibit
R6790 T9771 T9770 pobj animals,in
R6791 T9772 T9773 dep that,carry
R6792 T9773 T9771 relcl carry,animals
R6793 T9774 T9775 det a,allele
R6794 T9775 T9773 dobj allele,carry
R6795 T9776 T9775 amod null,allele
R6796 T9777 T9775 compound Agouti,allele
R6797 T9778 T9738 punct .,include
R6798 T9780 T9781 nummod One,target
R6799 T9781 T9783 nsubj target,is
R6800 T9782 T9781 amod potential,target
R6801 T9784 T9783 attr Alx4,is
R6802 T9785 T9784 punct ", ",Alx4
R6803 T9786 T9787 dep which,expressed
R6804 T9787 T9784 relcl expressed,Alx4
R6805 T9788 T9787 punct ", ",expressed
R6806 T9789 T9787 prep like,expressed
R6807 T9790 T9789 pobj Agouti,like
R6808 T9791 T9787 punct ", ",expressed
R6809 T9792 T9787 auxpass is,expressed
R6810 T9793 T9787 prep in,expressed
R6811 T9794 T9795 amod ventral,mesenchyme
R6812 T9795 T9793 pobj mesenchyme,in
R6813 T9796 T9795 amod embryonic,mesenchyme
R6814 T9797 T9787 punct ", ",expressed
R6815 T9798 T9787 cc and,expressed
R6816 T9799 T9787 punct ", ",expressed
R6817 T9800 T9801 advmod when,mutated
R6818 T9801 T9802 advcl mutated,affects
R6819 T9802 T9787 conj affects,expressed
R6820 T9803 T9802 punct ", ",affects
R6821 T9804 T9805 nmod hair,follicle
R6822 T9805 T9807 nmod follicle,development
R6823 T9806 T9805 punct -,follicle
R6824 T9807 T9802 dobj development,affects
R6825 T9808 T9809 advmod as,as
R6826 T9809 T9805 cc as,follicle
R6827 T9810 T9809 advmod well,as
R6828 T9811 T9805 conj limb,follicle
R6829 T9812 T9811 cc and,limb
R6830 T9813 T9811 conj craniofacial,limb
R6831 T9814 T9815 punct (,Qu
R6832 T9815 T9783 meta Qu,is
R6833 T9816 T9815 nmod et,Qu
R6834 T9817 T9815 nmod al.,Qu
R6835 T9818 T9815 nummod 1997,Qu
R6836 T9819 T9815 punct ", ",Qu
R6837 T9820 T9815 nummod 1998,Qu
R6838 T9821 T9815 punct ;,Qu
R6839 T9822 T9815 nmod Wu,Qu
R6840 T9823 T9815 nmod et,Qu
R6841 T9824 T9815 nmod al.,Qu
R6842 T9825 T9815 nummod 2000,Qu
R6843 T9826 T9815 punct ;,Qu
R6844 T9827 T9815 nmod Wuyts,Qu
R6845 T9828 T9815 nmod et,Qu
R6846 T9829 T9815 nmod al.,Qu
R6847 T9830 T9815 nummod 2000,Qu
R6848 T9831 T9815 punct ;,Qu
R6849 T9832 T9815 nmod Mavrogiannis,Qu
R6850 T9833 T9815 nmod et,Qu
R6851 T9834 T9815 nmod al.,Qu
R6852 T9835 T9815 nummod 2001,Qu
R6853 T9836 T9815 punct ),Qu
R6854 T9837 T9783 punct .,is
R6855 T9839 T9840 advmod However,appears
R6856 T9841 T9840 punct ", ",appears
R6857 T9842 T9840 nsubj expression,appears
R6858 T9843 T9842 prep of,expression
R6859 T9844 T9845 amod ventral,markers
R6860 T9845 T9843 pobj markers,of
R6861 T9846 T9847 amod such,as
R6862 T9847 T9845 prep as,markers
R6863 T9848 T9847 pobj Alx4,as
R6864 T9849 T9848 punct ", ",Alx4
R6865 T9850 T9851 advmod as,as
R6866 T9851 T9848 cc as,Alx4
R6867 T9852 T9851 advmod well,as
R6868 T9853 T9848 conj Alx3,Alx4
R6869 T9854 T9853 cc and,Alx3
R6870 T9855 T9853 conj Msx2,Alx3
R6871 T9856 T9840 punct ", ",appears
R6872 T9857 T9858 aux to,be
R6873 T9858 T9840 xcomp be,appears
R6874 T9859 T9858 acomp unaffected,be
R6875 T9860 T9858 prep at,be
R6876 T9861 T9860 pobj E11.5,at
R6877 T9862 T9858 prep in,be
R6878 T9863 T9864 compound deH,deH
R6879 T9864 T9866 compound deH,embryos
R6880 T9865 T9864 punct /,deH
R6881 T9866 T9862 pobj embryos,in
R6882 T9867 T9868 punct (,shown
R6883 T9868 T9858 parataxis shown,be
R6884 T9869 T9868 nsubj data,shown
R6885 T9870 T9868 neg not,shown
R6886 T9871 T9868 punct ),shown
R6887 T9872 T9840 punct .,appears