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PMC:314463 / 41343-44800 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T8496 0-8 NN denotes Genetics
T8497 9-11 IN denotes of
T8498 12-17 NN denotes Tbx15
T8499 17-313 sentence denotes Named for the presence of a DNA-binding domain first identified in the mouse Brachyury gene (haploinsufficiency causes a short tail), T box–containing genes have been identified as developmental regulators in a wide spectrum of tissues and multicellular organisms (reviewed in Papaioannou 2001).
T8500 18-23 VBN denotes Named
T8502 24-27 IN denotes for
T8503 28-31 DT denotes the
T8504 32-40 NN denotes presence
T8505 41-43 IN denotes of
T8506 44-45 DT denotes a
T8508 46-49 NN denotes DNA
T8510 49-50 HYPH denotes -
T8509 50-57 VBG denotes binding
T8507 58-64 NN denotes domain
T8511 65-70 RB denotes first
T8512 71-81 VBN denotes identified
T8513 82-84 IN denotes in
T8514 85-88 DT denotes the
T8516 89-94 NN denotes mouse
T8517 95-104 NN denotes Brachyury
T8515 105-109 NN denotes gene
T8518 110-111 -LRB- denotes (
T8520 111-129 NN denotes haploinsufficiency
T8519 130-136 VBZ denotes causes
T8521 137-138 DT denotes a
T8523 139-144 JJ denotes short
T8522 145-149 NN denotes tail
T8524 149-150 -RRB- denotes )
T8525 150-152 , denotes ,
T8526 152-153 NN denotes T
T8527 154-157 NN denotes box
T8529 157-158 HYPH denotes –
T8528 158-168 VBG denotes containing
T8530 169-174 NNS denotes genes
T8531 175-179 VBP denotes have
T8532 180-184 VBN denotes been
T8501 185-195 VBN denotes identified
T8533 196-198 IN denotes as
T8534 199-212 JJ denotes developmental
T8535 213-223 NNS denotes regulators
T8536 224-226 IN denotes in
T8537 227-228 DT denotes a
T8539 229-233 JJ denotes wide
T8538 234-242 NN denotes spectrum
T8540 243-245 IN denotes of
T8541 246-253 NNS denotes tissues
T8542 254-257 CC denotes and
T8543 258-271 JJ denotes multicellular
T8544 272-281 NNS denotes organisms
T8545 282-283 -LRB- denotes (
T8546 283-291 VBN denotes reviewed
T8547 292-294 IN denotes in
T8548 295-306 NNP denotes Papaioannou
T8549 307-311 CD denotes 2001
T8550 311-312 -RRB- denotes )
T8551 312-313 . denotes .
T8552 313-535 sentence denotes The Tbx15 subfamily, which also includes Tbx18 and Tbx22, is likely to have arisen during early chordate evolution since there is a single gene in amphioxus but no obvious homolog in the fly genome (Ruvinsky et al. 2000).
T8553 314-317 DT denotes The
T8555 318-323 NN denotes Tbx15
T8554 324-333 NN denotes subfamily
T8557 333-335 , denotes ,
T8558 335-340 WDT denotes which
T8560 341-345 RB denotes also
T8559 346-354 VBZ denotes includes
T8561 355-360 NN denotes Tbx18
T8562 361-364 CC denotes and
T8563 365-370 NN denotes Tbx22
T8564 370-372 , denotes ,
T8556 372-374 VBZ denotes is
T8565 375-381 JJ denotes likely
T8566 382-384 TO denotes to
T8568 385-389 VB denotes have
T8567 390-396 VBN denotes arisen
T8569 397-403 IN denotes during
T8570 404-409 JJ denotes early
T8572 410-418 NN denotes chordate
T8571 419-428 NN denotes evolution
T8573 429-434 IN denotes since
T8575 435-440 EX denotes there
T8574 441-443 VBZ denotes is
T8576 444-445 DT denotes a
T8578 446-452 JJ denotes single
T8577 453-457 NN denotes gene
T8579 458-460 IN denotes in
T8580 461-470 NN denotes amphioxus
T8581 471-474 CC denotes but
T8582 475-477 DT denotes no
T8584 478-485 JJ denotes obvious
T8583 486-493 NN denotes homolog
T8585 494-496 IN denotes in
T8586 497-500 DT denotes the
T8588 501-504 NN denotes fly
T8587 505-511 NN denotes genome
T8589 512-513 -LRB- denotes (
T8590 513-521 NNP denotes Ruvinsky
T8591 522-524 FW denotes et
T8592 525-528 FW denotes al.
T8593 529-533 CD denotes 2000
T8594 533-534 -RRB- denotes )
T8595 534-535 . denotes .
T8596 535-905 sentence denotes Consistent with this relationship, the three genes are expressed in partially overlapping patterns that include anterior somites (Tbx18 and Tbx22), limb mesenchyme (Tbx15 and Tbx18), and craniofacial mesenchyme (all three genes, Tbx15 more broadly than Tbx18 or Tbx22) (Agulnik et al. 1998; Kraus et al. 2001; Braybrook et al. 2002; Bush et al. 2002; Herr et al. 2003).
T8597 536-546 JJ denotes Consistent
T8599 547-551 IN denotes with
T8600 552-556 DT denotes this
T8601 557-569 NN denotes relationship
T8602 569-571 , denotes ,
T8603 571-574 DT denotes the
T8605 575-580 CD denotes three
T8604 581-586 NNS denotes genes
T8606 587-590 VBP denotes are
T8598 591-600 VBN denotes expressed
T8607 601-603 IN denotes in
T8608 604-613 RB denotes partially
T8609 614-625 VBG denotes overlapping
T8610 626-634 NNS denotes patterns
T8611 635-639 WDT denotes that
T8612 640-647 VBP denotes include
T8613 648-656 JJ denotes anterior
T8614 657-664 NNS denotes somites
T8615 665-666 -LRB- denotes (
T8616 666-671 NN denotes Tbx18
T8617 672-675 CC denotes and
T8618 676-681 NN denotes Tbx22
T8619 681-682 -RRB- denotes )
T8620 682-684 , denotes ,
T8621 684-688 NN denotes limb
T8622 689-699 NN denotes mesenchyme
T8623 700-701 -LRB- denotes (
T8624 701-706 NN denotes Tbx15
T8625 707-710 CC denotes and
T8626 711-716 NN denotes Tbx18
T8627 716-717 -RRB- denotes )
T8628 717-719 , denotes ,
T8629 719-722 CC denotes and
T8630 723-735 JJ denotes craniofacial
T8631 736-746 NN denotes mesenchyme
T8632 747-748 -LRB- denotes (
T8634 748-751 DT denotes all
T8635 752-757 CD denotes three
T8633 758-763 NNS denotes genes
T8636 763-765 , denotes ,
T8637 765-770 NN denotes Tbx15
T8638 771-775 RBR denotes more
T8639 776-783 RB denotes broadly
T8640 784-788 IN denotes than
T8641 789-794 NN denotes Tbx18
T8642 795-797 CC denotes or
T8643 798-803 NN denotes Tbx22
T8644 803-804 -RRB- denotes )
T8645 805-806 -LRB- denotes (
T8646 806-813 NNP denotes Agulnik
T8647 814-816 FW denotes et
T8648 817-820 FW denotes al.
T8649 821-825 CD denotes 1998
T8650 825-826 : denotes ;
T8651 827-832 NNP denotes Kraus
T8652 833-835 FW denotes et
T8653 836-839 FW denotes al.
T8654 840-844 CD denotes 2001
T8655 844-845 : denotes ;
T8656 846-855 NNP denotes Braybrook
T8657 856-858 FW denotes et
T8658 859-862 FW denotes al.
T8659 863-867 CD denotes 2002
T8660 867-868 : denotes ;
T8661 869-873 NNP denotes Bush
T8662 874-876 FW denotes et
T8663 877-880 FW denotes al.
T8664 881-885 CD denotes 2002
T8665 885-886 : denotes ;
T8666 887-891 NNP denotes Herr
T8667 892-894 FW denotes et
T8668 895-898 FW denotes al.
T8669 899-903 CD denotes 2003
T8670 903-904 -RRB- denotes )
T8671 904-905 . denotes .
T8672 905-1197 sentence denotes These observations suggest that an ancestral gene for Tbx15, Tbx18, and Tbx22 may have been important for craniofacial development in cephalochordates, with acquisition of additional expression patterns and developmental functions in the limb and the trunk during early vertebrate evolution.
T8673 906-911 DT denotes These
T8674 912-924 NNS denotes observations
T8675 925-932 VBP denotes suggest
T8676 933-937 IN denotes that
T8678 938-940 DT denotes an
T8680 941-950 JJ denotes ancestral
T8679 951-955 NN denotes gene
T8681 956-959 IN denotes for
T8682 960-965 NN denotes Tbx15
T8683 965-967 , denotes ,
T8684 967-972 NN denotes Tbx18
T8685 972-974 , denotes ,
T8686 974-977 CC denotes and
T8687 978-983 NN denotes Tbx22
T8688 984-987 MD denotes may
T8689 988-992 VB denotes have
T8677 993-997 VBN denotes been
T8690 998-1007 JJ denotes important
T8691 1008-1011 IN denotes for
T8692 1012-1024 JJ denotes craniofacial
T8693 1025-1036 NN denotes development
T8694 1037-1039 IN denotes in
T8695 1040-1056 NNS denotes cephalochordates
T8696 1056-1058 , denotes ,
T8697 1058-1062 IN denotes with
T8698 1063-1074 NN denotes acquisition
T8699 1075-1077 IN denotes of
T8700 1078-1088 JJ denotes additional
T8702 1089-1099 NN denotes expression
T8701 1100-1108 NNS denotes patterns
T8703 1109-1112 CC denotes and
T8704 1113-1126 JJ denotes developmental
T8705 1127-1136 NNS denotes functions
T8706 1137-1139 IN denotes in
T8707 1140-1143 DT denotes the
T8708 1144-1148 NN denotes limb
T8709 1149-1152 CC denotes and
T8710 1153-1156 DT denotes the
T8711 1157-1162 NN denotes trunk
T8712 1163-1169 IN denotes during
T8713 1170-1175 JJ denotes early
T8715 1176-1186 NN denotes vertebrate
T8714 1187-1196 NN denotes evolution
T8716 1196-1197 . denotes .
T8717 1197-1397 sentence denotes Expression of Tbx18 and Tbx22 has not been reported in embryonic flank mesenchyme, which suggests that Tbx15 is the only family member involved in establishing the dorsoventral identity of the trunk.
T8718 1198-1208 NN denotes Expression
T8720 1209-1211 IN denotes of
T8721 1212-1217 NN denotes Tbx18
T8722 1218-1221 CC denotes and
T8723 1222-1227 NN denotes Tbx22
T8724 1228-1231 VBZ denotes has
T8725 1232-1235 RB denotes not
T8726 1236-1240 VBN denotes been
T8719 1241-1249 VBN denotes reported
T8727 1250-1252 IN denotes in
T8728 1253-1262 JJ denotes embryonic
T8730 1263-1268 NN denotes flank
T8729 1269-1279 NN denotes mesenchyme
T8731 1279-1281 , denotes ,
T8732 1281-1286 WDT denotes which
T8733 1287-1295 VBZ denotes suggests
T8734 1296-1300 IN denotes that
T8736 1301-1306 NN denotes Tbx15
T8735 1307-1309 VBZ denotes is
T8737 1310-1313 DT denotes the
T8739 1314-1318 JJ denotes only
T8740 1319-1325 NN denotes family
T8738 1326-1332 NN denotes member
T8741 1333-1341 VBN denotes involved
T8742 1342-1344 IN denotes in
T8743 1345-1357 VBG denotes establishing
T8744 1358-1361 DT denotes the
T8746 1362-1374 JJ denotes dorsoventral
T8745 1375-1383 NN denotes identity
T8747 1384-1386 IN denotes of
T8748 1387-1390 DT denotes the
T8749 1391-1396 NN denotes trunk
T8750 1396-1397 . denotes .
T8751 1397-1599 sentence denotes However, it would not be surprising to find some degree of functional redundancy in animals mutated for two or three of the subfamily members in other body regions, particularly the limbs and the head.
T8752 1398-1405 RB denotes However
T8754 1405-1407 , denotes ,
T8755 1407-1409 PRP denotes it
T8756 1410-1415 MD denotes would
T8757 1416-1419 RB denotes not
T8753 1420-1422 VB denotes be
T8758 1423-1433 JJ denotes surprising
T8759 1434-1436 TO denotes to
T8760 1437-1441 VB denotes find
T8761 1442-1446 DT denotes some
T8762 1447-1453 NN denotes degree
T8763 1454-1456 IN denotes of
T8764 1457-1467 JJ denotes functional
T8765 1468-1478 NN denotes redundancy
T8766 1479-1481 IN denotes in
T8767 1482-1489 NNS denotes animals
T8768 1490-1497 VBN denotes mutated
T8769 1498-1501 IN denotes for
T8770 1502-1505 CD denotes two
T8771 1506-1508 CC denotes or
T8772 1509-1514 CD denotes three
T8773 1515-1517 IN denotes of
T8774 1518-1521 DT denotes the
T8776 1522-1531 NN denotes subfamily
T8775 1532-1539 NNS denotes members
T8777 1540-1542 IN denotes in
T8778 1543-1548 JJ denotes other
T8780 1549-1553 NN denotes body
T8779 1554-1561 NNS denotes regions
T8781 1561-1563 , denotes ,
T8782 1563-1575 RB denotes particularly
T8784 1576-1579 DT denotes the
T8783 1580-1585 NNS denotes limbs
T8785 1586-1589 CC denotes and
T8786 1590-1593 DT denotes the
T8787 1594-1598 NN denotes head
T8788 1598-1599 . denotes .
T8789 1599-1721 sentence denotes For example, mutations in Tbx22 cause the human syndrome X-linked cleft palate and ankyloglossia (Braybrook et al. 2001).
T8790 1600-1603 IN denotes For
T8792 1604-1611 NN denotes example
T8793 1611-1613 , denotes ,
T8794 1613-1622 NNS denotes mutations
T8795 1623-1625 IN denotes in
T8796 1626-1631 NN denotes Tbx22
T8791 1632-1637 VBP denotes cause
T8797 1638-1641 DT denotes the
T8799 1642-1647 JJ denotes human
T8798 1648-1656 NN denotes syndrome
T8800 1657-1658 NN denotes X
T8802 1658-1659 HYPH denotes -
T8801 1659-1665 VBN denotes linked
T8804 1666-1671 JJ denotes cleft
T8803 1672-1678 NN denotes palate
T8805 1679-1682 CC denotes and
T8806 1683-1696 NN denotes ankyloglossia
T8807 1697-1698 -LRB- denotes (
T8808 1698-1707 NNP denotes Braybrook
T8809 1708-1710 FW denotes et
T8810 1711-1714 FW denotes al.
T8811 1715-1719 CD denotes 2001
T8812 1719-1720 -RRB- denotes )
T8813 1720-1721 . denotes .
T8814 1721-1971 sentence denotes Despite high levels of Tbx22 expression in periocular embryonic mesenchyme (Braybrook et al. 2002; Bush et al. 2002; Herr et al. 2003), the condition does not affect the eye, perhaps because residual activity is provided by Tbx15 in the same region.
T8815 1722-1729 IN denotes Despite
T8817 1730-1734 JJ denotes high
T8818 1735-1741 NNS denotes levels
T8819 1742-1744 IN denotes of
T8820 1745-1750 NN denotes Tbx22
T8821 1751-1761 NN denotes expression
T8822 1762-1764 IN denotes in
T8823 1765-1775 JJ denotes periocular
T8825 1776-1785 JJ denotes embryonic
T8824 1786-1796 NN denotes mesenchyme
T8826 1797-1798 -LRB- denotes (
T8827 1798-1807 NNP denotes Braybrook
T8828 1808-1810 FW denotes et
T8829 1811-1814 FW denotes al.
T8830 1815-1819 CD denotes 2002
T8831 1819-1820 : denotes ;
T8832 1821-1825 NNP denotes Bush
T8833 1826-1828 FW denotes et
T8834 1829-1832 FW denotes al.
T8835 1833-1837 CD denotes 2002
T8836 1837-1838 : denotes ;
T8837 1839-1843 NNP denotes Herr
T8838 1844-1846 FW denotes et
T8839 1847-1850 FW denotes al.
T8840 1851-1855 CD denotes 2003
T8841 1855-1856 -RRB- denotes )
T8842 1856-1858 , denotes ,
T8843 1858-1861 DT denotes the
T8844 1862-1871 NN denotes condition
T8845 1872-1876 VBZ denotes does
T8846 1877-1880 RB denotes not
T8816 1881-1887 VB denotes affect
T8847 1888-1891 DT denotes the
T8848 1892-1895 NN denotes eye
T8849 1895-1897 , denotes ,
T8850 1897-1904 RB denotes perhaps
T8852 1905-1912 IN denotes because
T8853 1913-1921 JJ denotes residual
T8854 1922-1930 NN denotes activity
T8855 1931-1933 VBZ denotes is
T8851 1934-1942 VBN denotes provided
T8856 1943-1945 IN denotes by
T8857 1946-1951 NN denotes Tbx15
T8858 1952-1954 IN denotes in
T8859 1955-1958 DT denotes the
T8861 1959-1963 JJ denotes same
T8860 1964-1970 NN denotes region
T8862 1970-1971 . denotes .
T8863 1971-2273 sentence denotes In an initial description of the expression and map location of mouse Tbx15, Agulnik et al. (1998) suggested human Tbx15 that lies on Chromosome 1p11.1 as a candidate for acromegaloid facial appearance (AFA) syndrome, for which there is a weak positive LOD score to Chromosome 1p (Hughes et al. 1985).
T8864 1972-1974 IN denotes In
T8866 1975-1977 DT denotes an
T8868 1978-1985 JJ denotes initial
T8867 1986-1997 NN denotes description
T8869 1998-2000 IN denotes of
T8870 2001-2004 DT denotes the
T8871 2005-2015 NN denotes expression
T8872 2016-2019 CC denotes and
T8873 2020-2023 NN denotes map
T8874 2024-2032 NN denotes location
T8875 2033-2035 IN denotes of
T8876 2036-2041 NN denotes mouse
T8877 2042-2047 NN denotes Tbx15
T8878 2047-2049 , denotes ,
T8879 2049-2056 NNP denotes Agulnik
T8880 2057-2059 FW denotes et
T8881 2060-2063 FW denotes al.
T8882 2064-2065 -LRB- denotes (
T8883 2065-2069 CD denotes 1998
T8884 2069-2070 -RRB- denotes )
T8865 2071-2080 VBD denotes suggested
T8885 2081-2086 JJ denotes human
T8886 2087-2092 NN denotes Tbx15
T8887 2093-2097 WDT denotes that
T8888 2098-2102 VBZ denotes lies
T8889 2103-2105 IN denotes on
T8890 2106-2116 NN denotes Chromosome
T8891 2117-2123 NN denotes 1p11.1
T8892 2124-2126 IN denotes as
T8893 2127-2128 DT denotes a
T8894 2129-2138 NN denotes candidate
T8895 2139-2142 IN denotes for
T8896 2143-2155 JJ denotes acromegaloid
T8898 2156-2162 JJ denotes facial
T8897 2163-2173 NN denotes appearance
T8900 2174-2175 -LRB- denotes (
T8901 2175-2178 NN denotes AFA
T8902 2178-2179 -RRB- denotes )
T8899 2180-2188 NN denotes syndrome
T8903 2188-2190 , denotes ,
T8904 2190-2193 IN denotes for
T8906 2194-2199 WDT denotes which
T8907 2200-2205 EX denotes there
T8905 2206-2208 VBZ denotes is
T8908 2209-2210 DT denotes a
T8910 2211-2215 JJ denotes weak
T8911 2216-2224 JJ denotes positive
T8912 2225-2228 NN denotes LOD
T8909 2229-2234 NN denotes score
T8913 2235-2237 IN denotes to
T8914 2238-2248 NN denotes Chromosome
T8915 2249-2251 NN denotes 1p
T8916 2252-2253 -LRB- denotes (
T8917 2253-2259 NNP denotes Hughes
T8918 2260-2262 FW denotes et
T8919 2263-2266 FW denotes al.
T8920 2267-2271 CD denotes 1985
T8921 2271-2272 -RRB- denotes )
T8922 2272-2273 . denotes .
T8923 2273-2647 sentence denotes Originally described as a rare autosomal-dominant syndrome with progressive facial coarsening, overgrowth of the intraoral mucosa, and large, doughy hands, more recent case reports describe macrosomia, macrocephaly, or both and generalized hypertrichosis with progressive coarsening (Dallapiccola et al. 1992; Irvine et al. 1996; da Silva et al. 1998; Zelante et al. 2000).
T8924 2274-2284 RB denotes Originally
T8925 2285-2294 VBN denotes described
T8927 2295-2297 IN denotes as
T8928 2298-2299 DT denotes a
T8930 2300-2304 JJ denotes rare
T8931 2305-2314 JJ denotes autosomal
T8933 2314-2315 HYPH denotes -
T8932 2315-2323 JJ denotes dominant
T8929 2324-2332 NN denotes syndrome
T8934 2333-2337 IN denotes with
T8935 2338-2349 JJ denotes progressive
T8937 2350-2356 JJ denotes facial
T8936 2357-2367 NN denotes coarsening
T8938 2367-2369 , denotes ,
T8939 2369-2379 NN denotes overgrowth
T8940 2380-2382 IN denotes of
T8941 2383-2386 DT denotes the
T8943 2387-2396 JJ denotes intraoral
T8942 2397-2403 NN denotes mucosa
T8944 2403-2405 , denotes ,
T8945 2405-2408 CC denotes and
T8946 2409-2414 JJ denotes large
T8948 2414-2416 , denotes ,
T8949 2416-2422 JJ denotes doughy
T8947 2423-2428 NNS denotes hands
T8950 2428-2430 , denotes ,
T8951 2430-2434 RBR denotes more
T8952 2435-2441 JJ denotes recent
T8954 2442-2446 NN denotes case
T8953 2447-2454 NNS denotes reports
T8926 2455-2463 VBP denotes describe
T8955 2464-2474 NN denotes macrosomia
T8956 2474-2476 , denotes ,
T8957 2476-2488 NN denotes macrocephaly
T8958 2488-2490 , denotes ,
T8959 2490-2492 CC denotes or
T8960 2493-2497 DT denotes both
T8961 2498-2501 CC denotes and
T8962 2502-2513 VBN denotes generalized
T8963 2514-2528 NN denotes hypertrichosis
T8964 2529-2533 IN denotes with
T8965 2534-2545 JJ denotes progressive
T8966 2546-2556 NN denotes coarsening
T8967 2557-2558 -LRB- denotes (
T8968 2558-2570 NNP denotes Dallapiccola
T8969 2571-2573 FW denotes et
T8970 2574-2577 FW denotes al.
T8971 2578-2582 CD denotes 1992
T8972 2582-2583 : denotes ;
T8973 2584-2590 NNP denotes Irvine
T8974 2591-2593 FW denotes et
T8975 2594-2597 FW denotes al.
T8976 2598-2602 CD denotes 1996
T8977 2602-2603 : denotes ;
T8978 2604-2606 NNP denotes da
T8979 2607-2612 NNP denotes Silva
T8980 2613-2615 FW denotes et
T8981 2616-2619 FW denotes al.
T8982 2620-2624 CD denotes 1998
T8983 2624-2625 : denotes ;
T8984 2626-2633 NNP denotes Zelante
T8985 2634-2636 FW denotes et
T8986 2637-2640 FW denotes al.
T8987 2641-2645 CD denotes 2000
T8988 2645-2646 -RRB- denotes )
T8989 2646-2647 . denotes .
T8990 2647-2957 sentence denotes The deH phenotype exhibits little overlap with these features; instead, we suggest a more likely candidate for mutations of human TBX15 would be frontofacionasal syndrome, an unmapped autosomal recessive condition characterized by brachycephaly, blepharophimosis, and midface hypoplasia (Reardon et al. 1994).
T8991 2648-2651 DT denotes The
T8993 2652-2655 NN denotes deH
T8992 2656-2665 NN denotes phenotype
T8994 2666-2674 VBZ denotes exhibits
T8996 2675-2681 JJ denotes little
T8997 2682-2689 NN denotes overlap
T8998 2690-2694 IN denotes with
T8999 2695-2700 DT denotes these
T9000 2701-2709 NNS denotes features
T9001 2709-2710 : denotes ;
T9002 2711-2718 RB denotes instead
T9003 2718-2720 , denotes ,
T9004 2720-2722 PRP denotes we
T8995 2723-2730 VBP denotes suggest
T9005 2731-2732 DT denotes a
T9007 2733-2737 RBR denotes more
T9008 2738-2744 JJ denotes likely
T9006 2745-2754 NN denotes candidate
T9010 2755-2758 IN denotes for
T9011 2759-2768 NNS denotes mutations
T9012 2769-2771 IN denotes of
T9013 2772-2777 JJ denotes human
T9014 2778-2783 NN denotes TBX15
T9015 2784-2789 MD denotes would
T9009 2790-2792 VB denotes be
T9016 2793-2809 JJ denotes frontofacionasal
T9017 2810-2818 NN denotes syndrome
T9018 2818-2820 , denotes ,
T9019 2820-2822 DT denotes an
T9021 2823-2831 JJ denotes unmapped
T9022 2832-2841 JJ denotes autosomal
T9023 2842-2851 JJ denotes recessive
T9020 2852-2861 NN denotes condition
T9024 2862-2875 VBN denotes characterized
T9025 2876-2878 IN denotes by
T9026 2879-2892 RB denotes brachycephaly
T9027 2892-2894 , denotes ,
T9028 2894-2910 NN denotes blepharophimosis
T9029 2910-2912 , denotes ,
T9030 2912-2915 CC denotes and
T9031 2916-2923 JJ denotes midface
T9032 2924-2934 NN denotes hypoplasia
T9033 2935-2936 -LRB- denotes (
T9034 2936-2943 NNP denotes Reardon
T9035 2944-2946 FW denotes et
T9036 2947-2950 FW denotes al.
T9037 2951-2955 CD denotes 1994
T9038 2955-2956 -RRB- denotes )
T9039 2956-2957 . denotes .
T9040 2957-3210 sentence denotes Two of us (S. Kuijper and F. Meijlink) became interested in the deH mutation because of its effects on skeletal development (Curry 1959) and the possibility that the aristaless-related gene Alx3 might be allelic with droopy ear (ten Berge et al. 1998).
T9041 2958-2961 CD denotes Two
T9043 2962-2964 IN denotes of
T9044 2965-2967 PRP denotes us
T9045 2968-2969 -LRB- denotes (
T9046 2969-2971 NNP denotes S.
T9047 2972-2979 NNP denotes Kuijper
T9048 2980-2983 CC denotes and
T9049 2984-2986 NNP denotes F.
T9050 2987-2995 NNP denotes Meijlink
T9051 2995-2996 -RRB- denotes )
T9042 2997-3003 VBD denotes became
T9052 3004-3014 JJ denotes interested
T9053 3015-3017 IN denotes in
T9054 3018-3021 DT denotes the
T9056 3022-3025 NN denotes deH
T9055 3026-3034 NN denotes mutation
T9057 3035-3042 IN denotes because
T9058 3043-3045 IN denotes of
T9059 3046-3049 PRP$ denotes its
T9060 3050-3057 NNS denotes effects
T9061 3058-3060 IN denotes on
T9062 3061-3069 JJ denotes skeletal
T9063 3070-3081 NN denotes development
T9064 3082-3083 -LRB- denotes (
T9065 3083-3088 NNP denotes Curry
T9066 3089-3093 CD denotes 1959
T9067 3093-3094 -RRB- denotes )
T9068 3095-3098 CC denotes and
T9069 3099-3102 DT denotes the
T9070 3103-3114 NN denotes possibility
T9071 3115-3119 IN denotes that
T9073 3120-3123 DT denotes the
T9075 3124-3134 NN denotes aristaless
T9077 3134-3135 HYPH denotes -
T9076 3135-3142 VBN denotes related
T9074 3143-3147 NN denotes gene
T9078 3148-3152 NN denotes Alx3
T9079 3153-3158 MD denotes might
T9072 3159-3161 VB denotes be
T9080 3162-3169 JJ denotes allelic
T9081 3170-3174 IN denotes with
T9082 3175-3181 JJ denotes droopy
T9083 3182-3185 NN denotes ear
T9084 3186-3187 -LRB- denotes (
T9085 3187-3190 NNP denotes ten
T9086 3191-3196 NNP denotes Berge
T9087 3197-3199 FW denotes et
T9088 3200-3203 FW denotes al.
T9089 3204-3208 CD denotes 1998
T9090 3208-3209 -RRB- denotes )
T9091 3209-3210 . denotes .
T9092 3210-3457 sentence denotes In spite of similarities between skeletal phenotypes of deH and Alx3 or Alx4 mutants, subsequent experiments (unpublished data) excluded allelism of Alx3 and deH, and a full description of the Tbx15 skeletal phenotype will be published elsewhere.
T9093 3211-3213 IN denotes In
T9095 3214-3219 NN denotes spite
T9096 3220-3222 IN denotes of
T9097 3223-3235 NNS denotes similarities
T9098 3236-3243 IN denotes between
T9099 3244-3252 JJ denotes skeletal
T9100 3253-3263 NNS denotes phenotypes
T9101 3264-3266 IN denotes of
T9102 3267-3270 NN denotes deH
T9104 3271-3274 CC denotes and
T9105 3275-3279 NN denotes Alx3
T9106 3280-3282 CC denotes or
T9107 3283-3287 NN denotes Alx4
T9103 3288-3295 NNS denotes mutants
T9108 3295-3297 , denotes ,
T9109 3297-3307 JJ denotes subsequent
T9110 3308-3319 NNS denotes experiments
T9111 3320-3321 -LRB- denotes (
T9113 3321-3332 JJ denotes unpublished
T9112 3333-3337 NNS denotes data
T9114 3337-3338 -RRB- denotes )
T9094 3339-3347 VBD denotes excluded
T9115 3348-3356 NN denotes allelism
T9116 3357-3359 IN denotes of
T9117 3360-3364 NN denotes Alx3
T9118 3365-3368 CC denotes and
T9119 3369-3372 NN denotes deH
T9120 3372-3374 , denotes ,
T9121 3374-3377 CC denotes and
T9122 3378-3379 DT denotes a
T9124 3380-3384 JJ denotes full
T9123 3385-3396 NN denotes description
T9126 3397-3399 IN denotes of
T9127 3400-3403 DT denotes the
T9129 3404-3409 NN denotes Tbx15
T9130 3410-3418 JJ denotes skeletal
T9128 3419-3428 NN denotes phenotype
T9131 3429-3433 MD denotes will
T9132 3434-3436 VB denotes be
T9125 3437-3446 VBN denotes published
T9133 3447-3456 RB denotes elsewhere
T9134 3456-3457 . denotes .
R5787 T8497 T8496 prep of,Genetics
R5788 T8498 T8497 pobj Tbx15,of
R5789 T8500 T8501 advcl Named,identified
R5790 T8502 T8500 prep for,Named
R5791 T8503 T8504 det the,presence
R5792 T8504 T8502 pobj presence,for
R5793 T8505 T8504 prep of,presence
R5794 T8506 T8507 det a,domain
R5795 T8507 T8505 pobj domain,of
R5796 T8508 T8509 npadvmod DNA,binding
R5797 T8509 T8507 amod binding,domain
R5798 T8510 T8509 punct -,binding
R5799 T8511 T8512 advmod first,identified
R5800 T8512 T8507 acl identified,domain
R5801 T8513 T8512 prep in,identified
R5802 T8514 T8515 det the,gene
R5803 T8515 T8513 pobj gene,in
R5804 T8516 T8515 compound mouse,gene
R5805 T8517 T8515 compound Brachyury,gene
R5806 T8518 T8519 punct (,causes
R5807 T8519 T8500 parataxis causes,Named
R5808 T8520 T8519 nsubj haploinsufficiency,causes
R5809 T8521 T8522 det a,tail
R5810 T8522 T8519 dobj tail,causes
R5811 T8523 T8522 amod short,tail
R5812 T8524 T8519 punct ),causes
R5813 T8525 T8501 punct ", ",identified
R5814 T8526 T8527 compound T,box
R5815 T8527 T8528 npadvmod box,containing
R5816 T8528 T8530 amod containing,genes
R5817 T8529 T8528 punct –,containing
R5818 T8530 T8501 nsubjpass genes,identified
R5819 T8531 T8501 aux have,identified
R5820 T8532 T8501 auxpass been,identified
R5821 T8533 T8501 prep as,identified
R5822 T8534 T8535 amod developmental,regulators
R5823 T8535 T8533 pobj regulators,as
R5824 T8536 T8501 prep in,identified
R5825 T8537 T8538 det a,spectrum
R5826 T8538 T8536 pobj spectrum,in
R5827 T8539 T8538 amod wide,spectrum
R5828 T8540 T8538 prep of,spectrum
R5829 T8541 T8540 pobj tissues,of
R5830 T8542 T8541 cc and,tissues
R5831 T8543 T8544 amod multicellular,organisms
R5832 T8544 T8541 conj organisms,tissues
R5833 T8545 T8546 punct (,reviewed
R5834 T8546 T8501 parataxis reviewed,identified
R5835 T8547 T8546 prep in,reviewed
R5836 T8548 T8547 pobj Papaioannou,in
R5837 T8549 T8548 npadvmod 2001,Papaioannou
R5838 T8550 T8546 punct ),reviewed
R5839 T8551 T8501 punct .,identified
R5840 T8553 T8554 det The,subfamily
R5841 T8554 T8556 nsubj subfamily,is
R5842 T8555 T8554 compound Tbx15,subfamily
R5843 T8557 T8554 punct ", ",subfamily
R5844 T8558 T8559 dep which,includes
R5845 T8559 T8554 relcl includes,subfamily
R5846 T8560 T8559 advmod also,includes
R5847 T8561 T8559 dobj Tbx18,includes
R5848 T8562 T8561 cc and,Tbx18
R5849 T8563 T8561 conj Tbx22,Tbx18
R5850 T8564 T8556 punct ", ",is
R5851 T8565 T8556 acomp likely,is
R5852 T8566 T8567 aux to,arisen
R5853 T8567 T8565 xcomp arisen,likely
R5854 T8568 T8567 aux have,arisen
R5855 T8569 T8567 prep during,arisen
R5856 T8570 T8571 amod early,evolution
R5857 T8571 T8569 pobj evolution,during
R5858 T8572 T8571 compound chordate,evolution
R5859 T8573 T8574 mark since,is
R5860 T8574 T8567 advcl is,arisen
R5861 T8575 T8574 expl there,is
R5862 T8576 T8577 det a,gene
R5863 T8577 T8574 attr gene,is
R5864 T8578 T8577 amod single,gene
R5865 T8579 T8577 prep in,gene
R5866 T8580 T8579 pobj amphioxus,in
R5867 T8581 T8577 cc but,gene
R5868 T8582 T8583 det no,homolog
R5869 T8583 T8577 conj homolog,gene
R5870 T8584 T8583 amod obvious,homolog
R5871 T8585 T8583 prep in,homolog
R5872 T8586 T8587 det the,genome
R5873 T8587 T8585 pobj genome,in
R5874 T8588 T8587 compound fly,genome
R5875 T8589 T8590 punct (,Ruvinsky
R5876 T8590 T8574 meta Ruvinsky,is
R5877 T8591 T8590 nmod et,Ruvinsky
R5878 T8592 T8590 nmod al.,Ruvinsky
R5879 T8593 T8590 nummod 2000,Ruvinsky
R5880 T8594 T8590 punct ),Ruvinsky
R5881 T8595 T8556 punct .,is
R5882 T8597 T8598 advcl Consistent,expressed
R5883 T8599 T8597 prep with,Consistent
R5884 T8600 T8601 det this,relationship
R5885 T8601 T8599 pobj relationship,with
R5886 T8602 T8598 punct ", ",expressed
R5887 T8603 T8604 det the,genes
R5888 T8604 T8598 nsubjpass genes,expressed
R5889 T8605 T8604 nummod three,genes
R5890 T8606 T8598 auxpass are,expressed
R5891 T8607 T8598 prep in,expressed
R5892 T8608 T8609 advmod partially,overlapping
R5893 T8609 T8610 amod overlapping,patterns
R5894 T8610 T8607 pobj patterns,in
R5895 T8611 T8612 dep that,include
R5896 T8612 T8610 relcl include,patterns
R5897 T8613 T8614 amod anterior,somites
R5898 T8614 T8612 dobj somites,include
R5899 T8615 T8616 punct (,Tbx18
R5900 T8616 T8614 parataxis Tbx18,somites
R5901 T8617 T8616 cc and,Tbx18
R5902 T8618 T8616 conj Tbx22,Tbx18
R5903 T8619 T8616 punct ),Tbx18
R5904 T8620 T8614 punct ", ",somites
R5905 T8621 T8622 compound limb,mesenchyme
R5906 T8622 T8614 conj mesenchyme,somites
R5907 T8623 T8624 punct (,Tbx15
R5908 T8624 T8622 parataxis Tbx15,mesenchyme
R5909 T8625 T8624 cc and,Tbx15
R5910 T8626 T8624 conj Tbx18,Tbx15
R5911 T8627 T8624 punct ),Tbx15
R5912 T8628 T8622 punct ", ",mesenchyme
R5913 T8629 T8622 cc and,mesenchyme
R5914 T8630 T8631 amod craniofacial,mesenchyme
R5915 T8631 T8622 conj mesenchyme,mesenchyme
R5916 T8632 T8633 punct (,genes
R5917 T8633 T8631 parataxis genes,mesenchyme
R5918 T8634 T8633 det all,genes
R5919 T8635 T8633 nummod three,genes
R5920 T8636 T8633 punct ", ",genes
R5921 T8637 T8633 dep Tbx15,genes
R5922 T8638 T8639 advmod more,broadly
R5923 T8639 T8637 advmod broadly,Tbx15
R5924 T8640 T8639 prep than,broadly
R5925 T8641 T8640 pobj Tbx18,than
R5926 T8642 T8641 cc or,Tbx18
R5927 T8643 T8641 conj Tbx22,Tbx18
R5928 T8644 T8633 punct ),genes
R5929 T8645 T8646 punct (,Agulnik
R5930 T8646 T8612 meta Agulnik,include
R5931 T8647 T8646 nmod et,Agulnik
R5932 T8648 T8646 nmod al.,Agulnik
R5933 T8649 T8646 nummod 1998,Agulnik
R5934 T8650 T8646 punct ;,Agulnik
R5935 T8651 T8646 nmod Kraus,Agulnik
R5936 T8652 T8646 nmod et,Agulnik
R5937 T8653 T8646 nmod al.,Agulnik
R5938 T8654 T8646 nummod 2001,Agulnik
R5939 T8655 T8646 punct ;,Agulnik
R5940 T8656 T8646 nmod Braybrook,Agulnik
R5941 T8657 T8646 nmod et,Agulnik
R5942 T8658 T8646 nmod al.,Agulnik
R5943 T8659 T8646 nummod 2002,Agulnik
R5944 T8660 T8646 punct ;,Agulnik
R5945 T8661 T8646 nmod Bush,Agulnik
R5946 T8662 T8646 nmod et,Agulnik
R5947 T8663 T8646 nmod al.,Agulnik
R5948 T8664 T8646 nummod 2002,Agulnik
R5949 T8665 T8646 punct ;,Agulnik
R5950 T8666 T8646 nmod Herr,Agulnik
R5951 T8667 T8646 nmod et,Agulnik
R5952 T8668 T8646 nmod al.,Agulnik
R5953 T8669 T8646 nummod 2003,Agulnik
R5954 T8670 T8646 punct ),Agulnik
R5955 T8671 T8598 punct .,expressed
R5956 T8673 T8674 det These,observations
R5957 T8674 T8675 nsubj observations,suggest
R5958 T8676 T8677 mark that,been
R5959 T8677 T8675 ccomp been,suggest
R5960 T8678 T8679 det an,gene
R5961 T8679 T8677 nsubj gene,been
R5962 T8680 T8679 amod ancestral,gene
R5963 T8681 T8679 prep for,gene
R5964 T8682 T8681 pobj Tbx15,for
R5965 T8683 T8682 punct ", ",Tbx15
R5966 T8684 T8682 conj Tbx18,Tbx15
R5967 T8685 T8684 punct ", ",Tbx18
R5968 T8686 T8684 cc and,Tbx18
R5969 T8687 T8684 conj Tbx22,Tbx18
R5970 T8688 T8677 aux may,been
R5971 T8689 T8677 aux have,been
R5972 T8690 T8677 acomp important,been
R5973 T8691 T8677 prep for,been
R5974 T8692 T8693 amod craniofacial,development
R5975 T8693 T8691 pobj development,for
R5976 T8694 T8693 prep in,development
R5977 T8695 T8694 pobj cephalochordates,in
R5978 T8696 T8677 punct ", ",been
R5979 T8697 T8677 prep with,been
R5980 T8698 T8697 pobj acquisition,with
R5981 T8699 T8698 prep of,acquisition
R5982 T8700 T8701 amod additional,patterns
R5983 T8701 T8699 pobj patterns,of
R5984 T8702 T8701 compound expression,patterns
R5985 T8703 T8701 cc and,patterns
R5986 T8704 T8705 amod developmental,functions
R5987 T8705 T8701 conj functions,patterns
R5988 T8706 T8698 prep in,acquisition
R5989 T8707 T8708 det the,limb
R5990 T8708 T8706 pobj limb,in
R5991 T8709 T8708 cc and,limb
R5992 T8710 T8711 det the,trunk
R5993 T8711 T8708 conj trunk,limb
R5994 T8712 T8698 prep during,acquisition
R5995 T8713 T8714 amod early,evolution
R5996 T8714 T8712 pobj evolution,during
R5997 T8715 T8714 compound vertebrate,evolution
R5998 T8716 T8675 punct .,suggest
R5999 T8718 T8719 nsubjpass Expression,reported
R6000 T8720 T8718 prep of,Expression
R6001 T8721 T8720 pobj Tbx18,of
R6002 T8722 T8721 cc and,Tbx18
R6003 T8723 T8721 conj Tbx22,Tbx18
R6004 T8724 T8719 aux has,reported
R6005 T8725 T8719 neg not,reported
R6006 T8726 T8719 auxpass been,reported
R6007 T8727 T8719 prep in,reported
R6008 T8728 T8729 amod embryonic,mesenchyme
R6009 T8729 T8727 pobj mesenchyme,in
R6010 T8730 T8729 compound flank,mesenchyme
R6011 T8731 T8719 punct ", ",reported
R6012 T8732 T8733 dep which,suggests
R6013 T8733 T8719 advcl suggests,reported
R6014 T8734 T8735 mark that,is
R6015 T8735 T8733 ccomp is,suggests
R6016 T8736 T8735 nsubj Tbx15,is
R6017 T8737 T8738 det the,member
R6018 T8738 T8735 attr member,is
R6019 T8739 T8738 amod only,member
R6020 T8740 T8738 compound family,member
R6021 T8741 T8738 acl involved,member
R6022 T8742 T8741 prep in,involved
R6023 T8743 T8742 pcomp establishing,in
R6024 T8744 T8745 det the,identity
R6025 T8745 T8743 dobj identity,establishing
R6026 T8746 T8745 amod dorsoventral,identity
R6027 T8747 T8745 prep of,identity
R6028 T8748 T8749 det the,trunk
R6029 T8749 T8747 pobj trunk,of
R6030 T8750 T8719 punct .,reported
R6031 T8752 T8753 advmod However,be
R6032 T8754 T8753 punct ", ",be
R6033 T8755 T8753 nsubj it,be
R6034 T8756 T8753 aux would,be
R6035 T8757 T8753 neg not,be
R6036 T8758 T8753 acomp surprising,be
R6037 T8759 T8760 aux to,find
R6038 T8760 T8753 xcomp find,be
R6039 T8761 T8762 det some,degree
R6040 T8762 T8760 dobj degree,find
R6041 T8763 T8762 prep of,degree
R6042 T8764 T8765 amod functional,redundancy
R6043 T8765 T8763 pobj redundancy,of
R6044 T8766 T8760 prep in,find
R6045 T8767 T8766 pobj animals,in
R6046 T8768 T8767 acl mutated,animals
R6047 T8769 T8768 prep for,mutated
R6048 T8770 T8769 pobj two,for
R6049 T8771 T8770 cc or,two
R6050 T8772 T8770 conj three,two
R6051 T8773 T8770 prep of,two
R6052 T8774 T8775 det the,members
R6053 T8775 T8773 pobj members,of
R6054 T8776 T8775 compound subfamily,members
R6055 T8777 T8760 prep in,find
R6056 T8778 T8779 amod other,regions
R6057 T8779 T8777 pobj regions,in
R6058 T8780 T8779 compound body,regions
R6059 T8781 T8779 punct ", ",regions
R6060 T8782 T8783 advmod particularly,limbs
R6061 T8783 T8779 appos limbs,regions
R6062 T8784 T8783 det the,limbs
R6063 T8785 T8783 cc and,limbs
R6064 T8786 T8787 det the,head
R6065 T8787 T8783 conj head,limbs
R6066 T8788 T8753 punct .,be
R6067 T8790 T8791 prep For,cause
R6068 T8792 T8790 pobj example,For
R6069 T8793 T8791 punct ", ",cause
R6070 T8794 T8791 nsubj mutations,cause
R6071 T8795 T8794 prep in,mutations
R6072 T8796 T8795 pobj Tbx22,in
R6073 T8797 T8798 det the,syndrome
R6074 T8798 T8791 dobj syndrome,cause
R6075 T8799 T8798 amod human,syndrome
R6076 T8800 T8801 npadvmod X,linked
R6077 T8801 T8803 amod linked,palate
R6078 T8802 T8801 punct -,linked
R6079 T8803 T8798 appos palate,syndrome
R6080 T8804 T8803 amod cleft,palate
R6081 T8805 T8803 cc and,palate
R6082 T8806 T8803 conj ankyloglossia,palate
R6083 T8807 T8808 punct (,Braybrook
R6084 T8808 T8791 meta Braybrook,cause
R6085 T8809 T8808 nmod et,Braybrook
R6086 T8810 T8808 nmod al.,Braybrook
R6087 T8811 T8808 nummod 2001,Braybrook
R6088 T8812 T8808 punct ),Braybrook
R6089 T8813 T8791 punct .,cause
R6090 T8815 T8816 prep Despite,affect
R6091 T8817 T8818 amod high,levels
R6092 T8818 T8815 pobj levels,Despite
R6093 T8819 T8818 prep of,levels
R6094 T8820 T8821 compound Tbx22,expression
R6095 T8821 T8819 pobj expression,of
R6096 T8822 T8818 prep in,levels
R6097 T8823 T8824 amod periocular,mesenchyme
R6098 T8824 T8822 pobj mesenchyme,in
R6099 T8825 T8824 amod embryonic,mesenchyme
R6100 T8826 T8827 punct (,Braybrook
R6101 T8827 T8818 meta Braybrook,levels
R6102 T8828 T8827 nmod et,Braybrook
R6103 T8829 T8827 nmod al.,Braybrook
R6104 T8830 T8827 nummod 2002,Braybrook
R6105 T8831 T8827 punct ;,Braybrook
R6106 T8832 T8827 nmod Bush,Braybrook
R6107 T8833 T8827 nmod et,Braybrook
R6108 T8834 T8827 nmod al.,Braybrook
R6109 T8835 T8827 nummod 2002,Braybrook
R6110 T8836 T8827 punct ;,Braybrook
R6111 T8837 T8827 nmod Herr,Braybrook
R6112 T8838 T8827 nmod et,Braybrook
R6113 T8839 T8827 nmod al.,Braybrook
R6114 T8840 T8827 nummod 2003,Braybrook
R6115 T8841 T8827 punct ),Braybrook
R6116 T8842 T8816 punct ", ",affect
R6117 T8843 T8844 det the,condition
R6118 T8844 T8816 nsubj condition,affect
R6119 T8845 T8816 aux does,affect
R6120 T8846 T8816 neg not,affect
R6121 T8847 T8848 det the,eye
R6122 T8848 T8816 dobj eye,affect
R6123 T8849 T8816 punct ", ",affect
R6124 T8850 T8851 advmod perhaps,provided
R6125 T8851 T8816 advcl provided,affect
R6126 T8852 T8851 mark because,provided
R6127 T8853 T8854 amod residual,activity
R6128 T8854 T8851 nsubjpass activity,provided
R6129 T8855 T8851 auxpass is,provided
R6130 T8856 T8851 agent by,provided
R6131 T8857 T8856 pobj Tbx15,by
R6132 T8858 T8851 prep in,provided
R6133 T8859 T8860 det the,region
R6134 T8860 T8858 pobj region,in
R6135 T8861 T8860 amod same,region
R6136 T8862 T8816 punct .,affect
R6137 T8864 T8865 prep In,suggested
R6138 T8866 T8867 det an,description
R6139 T8867 T8864 pobj description,In
R6140 T8868 T8867 amod initial,description
R6141 T8869 T8867 prep of,description
R6142 T8870 T8871 det the,expression
R6143 T8871 T8869 pobj expression,of
R6144 T8872 T8871 cc and,expression
R6145 T8873 T8874 compound map,location
R6146 T8874 T8871 conj location,expression
R6147 T8875 T8871 prep of,expression
R6148 T8876 T8877 compound mouse,Tbx15
R6149 T8877 T8875 pobj Tbx15,of
R6150 T8878 T8865 punct ", ",suggested
R6151 T8879 T8865 nsubj Agulnik,suggested
R6152 T8880 T8881 advmod et,al.
R6153 T8881 T8879 advmod al.,Agulnik
R6154 T8882 T8879 punct (,Agulnik
R6155 T8883 T8879 npadvmod 1998,Agulnik
R6156 T8884 T8879 punct ),Agulnik
R6157 T8885 T8886 amod human,Tbx15
R6158 T8886 T8865 dobj Tbx15,suggested
R6159 T8887 T8888 dep that,lies
R6160 T8888 T8886 relcl lies,Tbx15
R6161 T8889 T8888 prep on,lies
R6162 T8890 T8891 compound Chromosome,1p11.1
R6163 T8891 T8889 pobj 1p11.1,on
R6164 T8892 T8865 prep as,suggested
R6165 T8893 T8894 det a,candidate
R6166 T8894 T8892 pobj candidate,as
R6167 T8895 T8894 prep for,candidate
R6168 T8896 T8897 amod acromegaloid,appearance
R6169 T8897 T8899 nmod appearance,syndrome
R6170 T8898 T8897 amod facial,appearance
R6171 T8899 T8895 pobj syndrome,for
R6172 T8900 T8897 punct (,appearance
R6173 T8901 T8897 appos AFA,appearance
R6174 T8902 T8899 punct ),syndrome
R6175 T8903 T8899 punct ", ",syndrome
R6176 T8904 T8905 prep for,is
R6177 T8905 T8899 relcl is,syndrome
R6178 T8906 T8904 pobj which,for
R6179 T8907 T8905 expl there,is
R6180 T8908 T8909 det a,score
R6181 T8909 T8905 attr score,is
R6182 T8910 T8909 amod weak,score
R6183 T8911 T8909 amod positive,score
R6184 T8912 T8909 compound LOD,score
R6185 T8913 T8909 prep to,score
R6186 T8914 T8915 compound Chromosome,1p
R6187 T8915 T8913 pobj 1p,to
R6188 T8916 T8917 punct (,Hughes
R6189 T8917 T8905 meta Hughes,is
R6190 T8918 T8917 nmod et,Hughes
R6191 T8919 T8917 nmod al.,Hughes
R6192 T8920 T8917 nummod 1985,Hughes
R6193 T8921 T8917 punct ),Hughes
R6194 T8922 T8865 punct .,suggested
R6195 T8924 T8925 advmod Originally,described
R6196 T8925 T8926 advcl described,describe
R6197 T8927 T8925 prep as,described
R6198 T8928 T8929 det a,syndrome
R6199 T8929 T8927 pobj syndrome,as
R6200 T8930 T8929 amod rare,syndrome
R6201 T8931 T8932 amod autosomal,dominant
R6202 T8932 T8929 amod dominant,syndrome
R6203 T8933 T8932 punct -,dominant
R6204 T8934 T8929 prep with,syndrome
R6205 T8935 T8936 amod progressive,coarsening
R6206 T8936 T8934 pobj coarsening,with
R6207 T8937 T8936 amod facial,coarsening
R6208 T8938 T8936 punct ", ",coarsening
R6209 T8939 T8936 conj overgrowth,coarsening
R6210 T8940 T8939 prep of,overgrowth
R6211 T8941 T8942 det the,mucosa
R6212 T8942 T8940 pobj mucosa,of
R6213 T8943 T8942 amod intraoral,mucosa
R6214 T8944 T8939 punct ", ",overgrowth
R6215 T8945 T8939 cc and,overgrowth
R6216 T8946 T8947 amod large,hands
R6217 T8947 T8939 conj hands,overgrowth
R6218 T8948 T8947 punct ", ",hands
R6219 T8949 T8947 amod doughy,hands
R6220 T8950 T8926 punct ", ",describe
R6221 T8951 T8952 advmod more,recent
R6222 T8952 T8953 amod recent,reports
R6223 T8953 T8926 nsubj reports,describe
R6224 T8954 T8953 compound case,reports
R6225 T8955 T8926 dobj macrosomia,describe
R6226 T8956 T8955 punct ", ",macrosomia
R6227 T8957 T8955 conj macrocephaly,macrosomia
R6228 T8958 T8957 punct ", ",macrocephaly
R6229 T8959 T8957 cc or,macrocephaly
R6230 T8960 T8957 conj both,macrocephaly
R6231 T8961 T8955 cc and,macrosomia
R6232 T8962 T8963 amod generalized,hypertrichosis
R6233 T8963 T8955 conj hypertrichosis,macrosomia
R6234 T8964 T8926 prep with,describe
R6235 T8965 T8966 amod progressive,coarsening
R6236 T8966 T8964 pobj coarsening,with
R6237 T8967 T8968 punct (,Dallapiccola
R6238 T8968 T8926 meta Dallapiccola,describe
R6239 T8969 T8968 nmod et,Dallapiccola
R6240 T8970 T8968 nmod al.,Dallapiccola
R6241 T8971 T8968 nummod 1992,Dallapiccola
R6242 T8972 T8968 punct ;,Dallapiccola
R6243 T8973 T8968 nmod Irvine,Dallapiccola
R6244 T8974 T8968 nmod et,Dallapiccola
R6245 T8975 T8968 nmod al.,Dallapiccola
R6246 T8976 T8968 nummod 1996,Dallapiccola
R6247 T8977 T8968 punct ;,Dallapiccola
R6248 T8978 T8968 nmod da,Dallapiccola
R6249 T8979 T8968 nmod Silva,Dallapiccola
R6250 T8980 T8968 nmod et,Dallapiccola
R6251 T8981 T8968 nmod al.,Dallapiccola
R6252 T8982 T8968 nummod 1998,Dallapiccola
R6253 T8983 T8968 punct ;,Dallapiccola
R6254 T8984 T8968 nmod Zelante,Dallapiccola
R6255 T8985 T8968 nmod et,Dallapiccola
R6256 T8986 T8968 nmod al.,Dallapiccola
R6257 T8987 T8968 nummod 2000,Dallapiccola
R6258 T8988 T8968 punct ),Dallapiccola
R6259 T8989 T8926 punct .,describe
R6260 T8991 T8992 det The,phenotype
R6261 T8992 T8994 nsubj phenotype,exhibits
R6262 T8993 T8992 compound deH,phenotype
R6263 T8994 T8995 ccomp exhibits,suggest
R6264 T8996 T8997 amod little,overlap
R6265 T8997 T8994 dobj overlap,exhibits
R6266 T8998 T8997 prep with,overlap
R6267 T8999 T9000 det these,features
R6268 T9000 T8998 pobj features,with
R6269 T9001 T8995 punct ;,suggest
R6270 T9002 T8995 advmod instead,suggest
R6271 T9003 T8995 punct ", ",suggest
R6272 T9004 T8995 nsubj we,suggest
R6273 T9005 T9006 det a,candidate
R6274 T9006 T9009 nsubj candidate,be
R6275 T9007 T9008 advmod more,likely
R6276 T9008 T9006 amod likely,candidate
R6277 T9009 T8995 advcl be,suggest
R6278 T9010 T9006 prep for,candidate
R6279 T9011 T9010 pobj mutations,for
R6280 T9012 T9011 prep of,mutations
R6281 T9013 T9014 amod human,TBX15
R6282 T9014 T9012 pobj TBX15,of
R6283 T9015 T9009 aux would,be
R6284 T9016 T9017 amod frontofacionasal,syndrome
R6285 T9017 T9009 attr syndrome,be
R6286 T9018 T9017 punct ", ",syndrome
R6287 T9019 T9020 det an,condition
R6288 T9020 T9017 appos condition,syndrome
R6289 T9021 T9020 amod unmapped,condition
R6290 T9022 T9020 amod autosomal,condition
R6291 T9023 T9020 amod recessive,condition
R6292 T9024 T9020 acl characterized,condition
R6293 T9025 T9024 agent by,characterized
R6294 T9026 T9025 pobj brachycephaly,by
R6295 T9027 T9026 punct ", ",brachycephaly
R6296 T9028 T9026 conj blepharophimosis,brachycephaly
R6297 T9029 T9028 punct ", ",blepharophimosis
R6298 T9030 T9028 cc and,blepharophimosis
R6299 T9031 T9032 amod midface,hypoplasia
R6300 T9032 T9028 conj hypoplasia,blepharophimosis
R6301 T9033 T9034 punct (,Reardon
R6302 T9034 T9024 meta Reardon,characterized
R6303 T9035 T9034 nmod et,Reardon
R6304 T9036 T9034 nmod al.,Reardon
R6305 T9037 T9034 nummod 1994,Reardon
R6306 T9038 T9034 punct ),Reardon
R6307 T9039 T8995 punct .,suggest
R6308 T9041 T9042 nsubj Two,became
R6309 T9043 T9041 prep of,Two
R6310 T9044 T9043 pobj us,of
R6311 T9045 T9041 punct (,Two
R6312 T9046 T9047 compound S.,Kuijper
R6313 T9047 T9041 appos Kuijper,Two
R6314 T9048 T9047 cc and,Kuijper
R6315 T9049 T9050 compound F.,Meijlink
R6316 T9050 T9047 conj Meijlink,Kuijper
R6317 T9051 T9042 punct ),became
R6318 T9052 T9042 acomp interested,became
R6319 T9053 T9052 prep in,interested
R6320 T9054 T9055 det the,mutation
R6321 T9055 T9053 pobj mutation,in
R6322 T9056 T9055 compound deH,mutation
R6323 T9057 T9042 prep because,became
R6324 T9058 T9057 pcomp of,because
R6325 T9059 T9060 poss its,effects
R6326 T9060 T9057 pobj effects,because
R6327 T9061 T9060 prep on,effects
R6328 T9062 T9063 amod skeletal,development
R6329 T9063 T9061 pobj development,on
R6330 T9064 T9065 punct (,Curry
R6331 T9065 T9060 meta Curry,effects
R6332 T9066 T9065 nummod 1959,Curry
R6333 T9067 T9065 punct ),Curry
R6334 T9068 T9060 cc and,effects
R6335 T9069 T9070 det the,possibility
R6336 T9070 T9060 conj possibility,effects
R6337 T9071 T9072 mark that,be
R6338 T9072 T9070 acl be,possibility
R6339 T9073 T9074 det the,gene
R6340 T9074 T9072 nsubj gene,be
R6341 T9075 T9076 npadvmod aristaless,related
R6342 T9076 T9074 amod related,gene
R6343 T9077 T9076 punct -,related
R6344 T9078 T9074 appos Alx3,gene
R6345 T9079 T9072 aux might,be
R6346 T9080 T9072 acomp allelic,be
R6347 T9081 T9080 prep with,allelic
R6348 T9082 T9083 amod droopy,ear
R6349 T9083 T9081 pobj ear,with
R6350 T9084 T9085 punct (,ten
R6351 T9085 T9072 meta ten,be
R6352 T9086 T9085 nmod Berge,ten
R6353 T9087 T9085 nmod et,ten
R6354 T9088 T9085 nmod al.,ten
R6355 T9089 T9085 nummod 1998,ten
R6356 T9090 T9085 punct ),ten
R6357 T9091 T9042 punct .,became
R6358 T9093 T9094 prep In,excluded
R6359 T9095 T9093 pobj spite,In
R6360 T9096 T9095 prep of,spite
R6361 T9097 T9096 pobj similarities,of
R6362 T9098 T9097 prep between,similarities
R6363 T9099 T9100 amod skeletal,phenotypes
R6364 T9100 T9098 pobj phenotypes,between
R6365 T9101 T9100 prep of,phenotypes
R6366 T9102 T9103 nmod deH,mutants
R6367 T9103 T9101 pobj mutants,of
R6368 T9104 T9102 cc and,deH
R6369 T9105 T9102 conj Alx3,deH
R6370 T9106 T9105 cc or,Alx3
R6371 T9107 T9105 conj Alx4,Alx3
R6372 T9108 T9094 punct ", ",excluded
R6373 T9109 T9110 amod subsequent,experiments
R6374 T9110 T9094 nsubj experiments,excluded
R6375 T9111 T9112 punct (,data
R6376 T9112 T9110 meta data,experiments
R6377 T9113 T9112 amod unpublished,data
R6378 T9114 T9112 punct ),data
R6379 T9115 T9094 dobj allelism,excluded
R6380 T9116 T9115 prep of,allelism
R6381 T9117 T9116 pobj Alx3,of
R6382 T9118 T9117 cc and,Alx3
R6383 T9119 T9117 conj deH,Alx3
R6384 T9120 T9094 punct ", ",excluded
R6385 T9121 T9094 cc and,excluded
R6386 T9122 T9123 det a,description
R6387 T9123 T9125 nsubjpass description,published
R6388 T9124 T9123 amod full,description
R6389 T9125 T9094 conj published,excluded
R6390 T9126 T9123 prep of,description
R6391 T9127 T9128 det the,phenotype
R6392 T9128 T9126 pobj phenotype,of
R6393 T9129 T9128 nmod Tbx15,phenotype
R6394 T9130 T9128 amod skeletal,phenotype
R6395 T9131 T9125 aux will,published
R6396 T9132 T9125 auxpass be,published
R6397 T9133 T9125 advmod elsewhere,published
R6398 T9134 T9094 punct .,excluded