| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T7946 |
0-8 |
JJ |
denotes |
Distinct |
| T7948 |
9-20 |
JJ |
denotes |
Morphologic |
| T7947 |
21-28 |
NNS |
denotes |
Regions |
| T7949 |
29-38 |
VBP |
denotes |
Represent |
| T7950 |
39-42 |
DT |
denotes |
the |
| T7951 |
43-46 |
NN |
denotes |
Sum |
| T7952 |
47-49 |
IN |
denotes |
of |
| T7953 |
50-59 |
JJ |
denotes |
Different |
| T7954 |
60-69 |
NNS |
denotes |
Gradients |
| T7955 |
69-323 |
sentence |
denotes |
The visual boundary between dorsal and ventral skin in at/at mice is reminiscent of other systems in which adjacent compartments enforce a binary choice between alternative patterns of gene expression and cell fate (reviewed in Dahmann and Basler 1999). |
| T7956 |
70-73 |
DT |
denotes |
The |
| T7958 |
74-80 |
JJ |
denotes |
visual |
| T7957 |
81-89 |
NN |
denotes |
boundary |
| T7960 |
90-97 |
IN |
denotes |
between |
| T7961 |
98-104 |
JJ |
denotes |
dorsal |
| T7963 |
105-108 |
CC |
denotes |
and |
| T7964 |
109-116 |
JJ |
denotes |
ventral |
| T7962 |
117-121 |
NN |
denotes |
skin |
| T7965 |
122-124 |
IN |
denotes |
in |
| T7966 |
125-127 |
NN |
denotes |
at |
| T7968 |
127-128 |
SYM |
denotes |
/ |
| T7967 |
128-130 |
NN |
denotes |
at |
| T7969 |
131-135 |
NNS |
denotes |
mice |
| T7959 |
136-138 |
VBZ |
denotes |
is |
| T7970 |
139-150 |
JJ |
denotes |
reminiscent |
| T7971 |
151-153 |
IN |
denotes |
of |
| T7972 |
154-159 |
JJ |
denotes |
other |
| T7973 |
160-167 |
NNS |
denotes |
systems |
| T7974 |
168-170 |
IN |
denotes |
in |
| T7976 |
171-176 |
WDT |
denotes |
which |
| T7977 |
177-185 |
JJ |
denotes |
adjacent |
| T7978 |
186-198 |
NNS |
denotes |
compartments |
| T7975 |
199-206 |
VBP |
denotes |
enforce |
| T7979 |
207-208 |
DT |
denotes |
a |
| T7981 |
209-215 |
JJ |
denotes |
binary |
| T7980 |
216-222 |
NN |
denotes |
choice |
| T7982 |
223-230 |
IN |
denotes |
between |
| T7983 |
231-242 |
JJ |
denotes |
alternative |
| T7984 |
243-251 |
NNS |
denotes |
patterns |
| T7985 |
252-254 |
IN |
denotes |
of |
| T7986 |
255-259 |
NN |
denotes |
gene |
| T7987 |
260-270 |
NN |
denotes |
expression |
| T7988 |
271-274 |
CC |
denotes |
and |
| T7989 |
275-279 |
NN |
denotes |
cell |
| T7990 |
280-284 |
NN |
denotes |
fate |
| T7991 |
285-286 |
-LRB- |
denotes |
( |
| T7992 |
286-294 |
VBN |
denotes |
reviewed |
| T7993 |
295-297 |
IN |
denotes |
in |
| T7994 |
298-305 |
NNP |
denotes |
Dahmann |
| T7995 |
306-309 |
CC |
denotes |
and |
| T7996 |
310-316 |
NNP |
denotes |
Basler |
| T7997 |
317-321 |
CD |
denotes |
1999 |
| T7998 |
321-322 |
-RRB- |
denotes |
) |
| T7999 |
322-323 |
. |
denotes |
. |
| T8000 |
323-579 |
sentence |
denotes |
However, Agouti mRNA in both embryonic and postnatal skin is distributed along a gradient whose dorsal boundary is indistinct and overlaps with two additional gradients recognized by their effects on hair length and histochemical staining for melanocytes. |
| T8001 |
324-331 |
RB |
denotes |
However |
| T8003 |
331-333 |
, |
denotes |
, |
| T8004 |
333-339 |
NN |
denotes |
Agouti |
| T8005 |
340-344 |
NN |
denotes |
mRNA |
| T8006 |
345-347 |
IN |
denotes |
in |
| T8007 |
348-352 |
CC |
denotes |
both |
| T8008 |
353-362 |
JJ |
denotes |
embryonic |
| T8010 |
363-366 |
CC |
denotes |
and |
| T8011 |
367-376 |
JJ |
denotes |
postnatal |
| T8009 |
377-381 |
NN |
denotes |
skin |
| T8012 |
382-384 |
VBZ |
denotes |
is |
| T8002 |
385-396 |
VBN |
denotes |
distributed |
| T8013 |
397-402 |
IN |
denotes |
along |
| T8014 |
403-404 |
DT |
denotes |
a |
| T8015 |
405-413 |
NN |
denotes |
gradient |
| T8016 |
414-419 |
WP$ |
denotes |
whose |
| T8018 |
420-426 |
JJ |
denotes |
dorsal |
| T8017 |
427-435 |
NN |
denotes |
boundary |
| T8019 |
436-438 |
VBZ |
denotes |
is |
| T8020 |
439-449 |
JJ |
denotes |
indistinct |
| T8021 |
450-453 |
CC |
denotes |
and |
| T8022 |
454-462 |
VBZ |
denotes |
overlaps |
| T8023 |
463-467 |
IN |
denotes |
with |
| T8024 |
468-471 |
CD |
denotes |
two |
| T8026 |
472-482 |
JJ |
denotes |
additional |
| T8025 |
483-492 |
NNS |
denotes |
gradients |
| T8027 |
493-503 |
VBN |
denotes |
recognized |
| T8028 |
504-506 |
IN |
denotes |
by |
| T8029 |
507-512 |
PRP$ |
denotes |
their |
| T8030 |
513-520 |
NNS |
denotes |
effects |
| T8031 |
521-523 |
IN |
denotes |
on |
| T8032 |
524-528 |
NN |
denotes |
hair |
| T8033 |
529-535 |
NN |
denotes |
length |
| T8034 |
536-539 |
CC |
denotes |
and |
| T8035 |
540-553 |
JJ |
denotes |
histochemical |
| T8036 |
554-562 |
NN |
denotes |
staining |
| T8037 |
563-566 |
IN |
denotes |
for |
| T8038 |
567-578 |
NNS |
denotes |
melanocytes |
| T8039 |
578-579 |
. |
denotes |
. |
| T8040 |
579-748 |
sentence |
denotes |
The three gradients are close but not congruent, and it is their proximity that gives rise to the superficial distinction between dorsal and ventral skin of at/at mice. |
| T8041 |
580-583 |
DT |
denotes |
The |
| T8043 |
584-589 |
CD |
denotes |
three |
| T8042 |
590-599 |
NNS |
denotes |
gradients |
| T8044 |
600-603 |
VBP |
denotes |
are |
| T8045 |
604-609 |
JJ |
denotes |
close |
| T8046 |
610-613 |
CC |
denotes |
but |
| T8047 |
614-617 |
RB |
denotes |
not |
| T8048 |
618-627 |
JJ |
denotes |
congruent |
| T8049 |
627-629 |
, |
denotes |
, |
| T8050 |
629-632 |
CC |
denotes |
and |
| T8051 |
633-635 |
PRP |
denotes |
it |
| T8052 |
636-638 |
VBZ |
denotes |
is |
| T8053 |
639-644 |
PRP$ |
denotes |
their |
| T8054 |
645-654 |
NN |
denotes |
proximity |
| T8055 |
655-659 |
WDT |
denotes |
that |
| T8056 |
660-665 |
VBZ |
denotes |
gives |
| T8057 |
666-670 |
NN |
denotes |
rise |
| T8058 |
671-673 |
IN |
denotes |
to |
| T8059 |
674-677 |
DT |
denotes |
the |
| T8061 |
678-689 |
JJ |
denotes |
superficial |
| T8060 |
690-701 |
NN |
denotes |
distinction |
| T8062 |
702-709 |
IN |
denotes |
between |
| T8063 |
710-716 |
JJ |
denotes |
dorsal |
| T8065 |
717-720 |
CC |
denotes |
and |
| T8066 |
721-728 |
JJ |
denotes |
ventral |
| T8064 |
729-733 |
NN |
denotes |
skin |
| T8067 |
734-736 |
IN |
denotes |
of |
| T8068 |
737-739 |
NN |
denotes |
at |
| T8070 |
739-740 |
SYM |
denotes |
/ |
| T8069 |
740-742 |
NN |
denotes |
at |
| T8071 |
743-747 |
NNS |
denotes |
mice |
| T8072 |
747-748 |
. |
denotes |
. |
| T8073 |
748-936 |
sentence |
denotes |
Indeed, slight differences between the regions of transition for pigment-type switching and pigment content give rise to a subtle yellow stripe along the flank (see Figures 1, 2, and 9A). |
| T8074 |
749-755 |
RB |
denotes |
Indeed |
| T8076 |
755-757 |
, |
denotes |
, |
| T8077 |
757-763 |
JJ |
denotes |
slight |
| T8078 |
764-775 |
NNS |
denotes |
differences |
| T8079 |
776-783 |
IN |
denotes |
between |
| T8080 |
784-787 |
DT |
denotes |
the |
| T8081 |
788-795 |
NNS |
denotes |
regions |
| T8082 |
796-798 |
IN |
denotes |
of |
| T8083 |
799-809 |
NN |
denotes |
transition |
| T8084 |
810-813 |
IN |
denotes |
for |
| T8085 |
814-821 |
NN |
denotes |
pigment |
| T8087 |
821-822 |
HYPH |
denotes |
- |
| T8086 |
822-826 |
NN |
denotes |
type |
| T8088 |
827-836 |
NN |
denotes |
switching |
| T8089 |
837-840 |
CC |
denotes |
and |
| T8090 |
841-848 |
NN |
denotes |
pigment |
| T8091 |
849-856 |
NN |
denotes |
content |
| T8075 |
857-861 |
VBP |
denotes |
give |
| T8092 |
862-866 |
NN |
denotes |
rise |
| T8093 |
867-869 |
IN |
denotes |
to |
| T8094 |
870-871 |
DT |
denotes |
a |
| T8096 |
872-878 |
JJ |
denotes |
subtle |
| T8097 |
879-885 |
JJ |
denotes |
yellow |
| T8095 |
886-892 |
NN |
denotes |
stripe |
| T8098 |
893-898 |
IN |
denotes |
along |
| T8099 |
899-902 |
DT |
denotes |
the |
| T8100 |
903-908 |
NN |
denotes |
flank |
| T8101 |
909-910 |
-LRB- |
denotes |
( |
| T8102 |
910-913 |
VB |
denotes |
see |
| T8103 |
914-921 |
NNS |
denotes |
Figures |
| T8104 |
922-923 |
CD |
denotes |
1 |
| T8105 |
923-925 |
, |
denotes |
, |
| T8106 |
925-926 |
CD |
denotes |
2 |
| T8107 |
926-928 |
, |
denotes |
, |
| T8108 |
928-931 |
CC |
denotes |
and |
| T8109 |
932-934 |
CD |
denotes |
9A |
| T8110 |
934-935 |
-RRB- |
denotes |
) |
| T8111 |
935-936 |
. |
denotes |
. |
| T8112 |
936-1202 |
sentence |
denotes |
Levels of Agouti mRNA remain high throughout the entire ventrum, but hair pigment content is reduced, giving rise to a cream-colored region in the ventrum that, depending on age and genetic backgrounds, may appear more or less distinct from the yellow flank stripe. |
| T8113 |
937-943 |
NNS |
denotes |
Levels |
| T8115 |
944-946 |
IN |
denotes |
of |
| T8116 |
947-953 |
NN |
denotes |
Agouti |
| T8117 |
954-958 |
NN |
denotes |
mRNA |
| T8114 |
959-965 |
VBP |
denotes |
remain |
| T8118 |
966-970 |
JJ |
denotes |
high |
| T8119 |
971-981 |
IN |
denotes |
throughout |
| T8120 |
982-985 |
DT |
denotes |
the |
| T8122 |
986-992 |
JJ |
denotes |
entire |
| T8121 |
993-1000 |
NN |
denotes |
ventrum |
| T8123 |
1000-1002 |
, |
denotes |
, |
| T8124 |
1002-1005 |
CC |
denotes |
but |
| T8125 |
1006-1010 |
NN |
denotes |
hair |
| T8127 |
1011-1018 |
NN |
denotes |
pigment |
| T8126 |
1019-1026 |
NN |
denotes |
content |
| T8129 |
1027-1029 |
VBZ |
denotes |
is |
| T8128 |
1030-1037 |
VBN |
denotes |
reduced |
| T8130 |
1037-1039 |
, |
denotes |
, |
| T8131 |
1039-1045 |
VBG |
denotes |
giving |
| T8132 |
1046-1050 |
NN |
denotes |
rise |
| T8133 |
1051-1053 |
IN |
denotes |
to |
| T8134 |
1054-1055 |
DT |
denotes |
a |
| T8136 |
1056-1061 |
NN |
denotes |
cream |
| T8138 |
1061-1062 |
HYPH |
denotes |
- |
| T8137 |
1062-1069 |
VBN |
denotes |
colored |
| T8135 |
1070-1076 |
NN |
denotes |
region |
| T8139 |
1077-1079 |
IN |
denotes |
in |
| T8140 |
1080-1083 |
DT |
denotes |
the |
| T8141 |
1084-1091 |
NN |
denotes |
ventrum |
| T8142 |
1092-1096 |
WDT |
denotes |
that |
| T8144 |
1096-1098 |
, |
denotes |
, |
| T8145 |
1098-1107 |
VBG |
denotes |
depending |
| T8146 |
1108-1110 |
IN |
denotes |
on |
| T8147 |
1111-1114 |
NN |
denotes |
age |
| T8148 |
1115-1118 |
CC |
denotes |
and |
| T8149 |
1119-1126 |
JJ |
denotes |
genetic |
| T8150 |
1127-1138 |
NNS |
denotes |
backgrounds |
| T8151 |
1138-1140 |
, |
denotes |
, |
| T8152 |
1140-1143 |
MD |
denotes |
may |
| T8143 |
1144-1150 |
VB |
denotes |
appear |
| T8153 |
1151-1155 |
RBR |
denotes |
more |
| T8155 |
1156-1158 |
CC |
denotes |
or |
| T8156 |
1159-1163 |
RBR |
denotes |
less |
| T8154 |
1164-1172 |
JJ |
denotes |
distinct |
| T8157 |
1173-1177 |
IN |
denotes |
from |
| T8158 |
1178-1181 |
DT |
denotes |
the |
| T8160 |
1182-1188 |
JJ |
denotes |
yellow |
| T8161 |
1189-1194 |
NN |
denotes |
flank |
| T8159 |
1195-1201 |
NN |
denotes |
stripe |
| T8162 |
1201-1202 |
. |
denotes |
. |
| T8163 |
1202-2722 |
sentence |
denotes |
Figure 9 Model for Acquisition of Dorsoventral Patterning in the Trunk and the Role of Tbx15
(A) A tricolor pigmentation pattern is generated by the combination of distinct mechanisms that affect distribution of Agouti mRNA and histochemical staining for melanocytes; effects of the latter mechanism by itself are evident in ae/ae mice (see Figure 1). In at/at mice, reduced hair melanocyte activity and high levels of Agouti mRNA in the ventrum lead to a cream color; as melanocyte activity gradually increases towards the dorsum, a lateral stripe is apparent on the flank. The distributions of Agouti mRNA and histochemical staining for melanocytes are both affected by Tbx15 and are externally evident by a widening of the lateral stripe and an increased proportion of total skin occupied by the cream-colored area.
(B) The lateral yellow stripe in at/at mice lies at the same level as the limb dorsoventral boundary. As described in the text, we propose that distinct dorsoventral compartments in ectoderm of the trunk provide an instructional cue to the mesoderm, leading to expression of Tbx15 in dorsal trunk mesenchyme and acquisition of dorsal dermis character. In the absence of Tbx15, dorsal mesenchyme assumes ventral characteristics instead. Loss of Tbx15 affects dorsoventral transitions of hair length, pigment content, and expression of the ventral-specific Agouti isoform; however, the former two effects are subtle and contribute little, if at all, to the abnormal pigmentation of adult deH/deH mice. |
| T8164 |
2459-2463 |
NN |
denotes |
Loss |
| T8166 |
2464-2466 |
IN |
denotes |
of |
| T8167 |
2467-2472 |
NN |
denotes |
Tbx15 |
| T8165 |
2473-2480 |
VBZ |
denotes |
affects |
| T8169 |
2481-2493 |
JJ |
denotes |
dorsoventral |
| T8170 |
2494-2505 |
NNS |
denotes |
transitions |
| T8171 |
2506-2508 |
IN |
denotes |
of |
| T8172 |
2509-2513 |
NN |
denotes |
hair |
| T8173 |
2514-2520 |
NN |
denotes |
length |
| T8174 |
2520-2522 |
, |
denotes |
, |
| T8175 |
2522-2529 |
NN |
denotes |
pigment |
| T8176 |
2530-2537 |
NN |
denotes |
content |
| T8177 |
2537-2539 |
, |
denotes |
, |
| T8178 |
2539-2542 |
CC |
denotes |
and |
| T8179 |
2543-2553 |
NN |
denotes |
expression |
| T8180 |
2554-2556 |
IN |
denotes |
of |
| T8181 |
2557-2560 |
DT |
denotes |
the |
| T8183 |
2561-2568 |
JJ |
denotes |
ventral |
| T8185 |
2568-2569 |
HYPH |
denotes |
- |
| T8184 |
2569-2577 |
JJ |
denotes |
specific |
| T8186 |
2578-2584 |
NN |
denotes |
Agouti |
| T8182 |
2585-2592 |
NN |
denotes |
isoform |
| T8187 |
2592-2593 |
: |
denotes |
; |
| T8188 |
2594-2601 |
RB |
denotes |
however |
| T8189 |
2601-2603 |
, |
denotes |
, |
| T8190 |
2603-2606 |
DT |
denotes |
the |
| T8192 |
2607-2613 |
JJ |
denotes |
former |
| T8193 |
2614-2617 |
CD |
denotes |
two |
| T8191 |
2618-2625 |
NNS |
denotes |
effects |
| T8168 |
2626-2629 |
VBP |
denotes |
are |
| T8194 |
2630-2636 |
JJ |
denotes |
subtle |
| T8195 |
2637-2640 |
CC |
denotes |
and |
| T8196 |
2641-2651 |
VBP |
denotes |
contribute |
| T8197 |
2652-2658 |
JJ |
denotes |
little |
| T8198 |
2658-2660 |
, |
denotes |
, |
| T8200 |
2660-2662 |
IN |
denotes |
if |
| T8201 |
2663-2665 |
RB |
denotes |
at |
| T8199 |
2666-2669 |
RB |
denotes |
all |
| T8202 |
2669-2671 |
, |
denotes |
, |
| T8203 |
2671-2673 |
IN |
denotes |
to |
| T8204 |
2674-2677 |
DT |
denotes |
the |
| T8206 |
2678-2686 |
JJ |
denotes |
abnormal |
| T8205 |
2687-2699 |
NN |
denotes |
pigmentation |
| T8207 |
2700-2702 |
IN |
denotes |
of |
| T8208 |
2703-2708 |
JJ |
denotes |
adult |
| T8210 |
2709-2712 |
NN |
denotes |
deH |
| T8212 |
2712-2713 |
SYM |
denotes |
/ |
| T8211 |
2713-2716 |
NN |
denotes |
deH |
| T8209 |
2717-2721 |
NNS |
denotes |
mice |
| T8213 |
2721-2722 |
. |
denotes |
. |
| T8214 |
2722-2933 |
sentence |
denotes |
Thus, despite the abnormal pattern of dark skin in neonatal deH/deH mice (e.g., Figure 2D), the most obvious feature in adults is dorsal displacement of the “boundary” between black and yellow hair (Figure 9A). |
| T8215 |
2723-2727 |
RB |
denotes |
Thus |
| T8217 |
2727-2729 |
, |
denotes |
, |
| T8218 |
2729-2736 |
IN |
denotes |
despite |
| T8219 |
2737-2740 |
DT |
denotes |
the |
| T8221 |
2741-2749 |
JJ |
denotes |
abnormal |
| T8220 |
2750-2757 |
NN |
denotes |
pattern |
| T8222 |
2758-2760 |
IN |
denotes |
of |
| T8223 |
2761-2765 |
JJ |
denotes |
dark |
| T8224 |
2766-2770 |
NN |
denotes |
skin |
| T8225 |
2771-2773 |
IN |
denotes |
in |
| T8226 |
2774-2782 |
JJ |
denotes |
neonatal |
| T8228 |
2783-2786 |
NN |
denotes |
deH |
| T8230 |
2786-2787 |
SYM |
denotes |
/ |
| T8229 |
2787-2790 |
NN |
denotes |
deH |
| T8227 |
2791-2795 |
NNS |
denotes |
mice |
| T8231 |
2796-2797 |
-LRB- |
denotes |
( |
| T8233 |
2797-2801 |
FW |
denotes |
e.g. |
| T8234 |
2801-2803 |
, |
denotes |
, |
| T8232 |
2803-2809 |
NN |
denotes |
Figure |
| T8235 |
2810-2812 |
CD |
denotes |
2D |
| T8236 |
2812-2813 |
-RRB- |
denotes |
) |
| T8237 |
2813-2815 |
, |
denotes |
, |
| T8238 |
2815-2818 |
DT |
denotes |
the |
| T8240 |
2819-2823 |
RBS |
denotes |
most |
| T8241 |
2824-2831 |
JJ |
denotes |
obvious |
| T8239 |
2832-2839 |
NN |
denotes |
feature |
| T8242 |
2840-2842 |
IN |
denotes |
in |
| T8243 |
2843-2849 |
NNS |
denotes |
adults |
| T8216 |
2850-2852 |
VBZ |
denotes |
is |
| T8244 |
2853-2859 |
JJ |
denotes |
dorsal |
| T8245 |
2860-2872 |
NN |
denotes |
displacement |
| T8246 |
2873-2875 |
IN |
denotes |
of |
| T8247 |
2876-2879 |
DT |
denotes |
the |
| T8249 |
2880-2881 |
`` |
denotes |
“ |
| T8248 |
2881-2889 |
NN |
denotes |
boundary |
| T8250 |
2889-2890 |
'' |
denotes |
” |
| T8251 |
2891-2898 |
IN |
denotes |
between |
| T8252 |
2899-2904 |
JJ |
denotes |
black |
| T8254 |
2905-2908 |
CC |
denotes |
and |
| T8255 |
2909-2915 |
JJ |
denotes |
yellow |
| T8253 |
2916-2920 |
NN |
denotes |
hair |
| T8256 |
2921-2922 |
-LRB- |
denotes |
( |
| T8257 |
2922-2928 |
NN |
denotes |
Figure |
| T8258 |
2929-2931 |
CD |
denotes |
9A |
| T8259 |
2931-2932 |
-RRB- |
denotes |
) |
| T8260 |
2932-2933 |
. |
denotes |
. |
| R5485 |
T7946 |
T7947 |
amod |
Distinct,Regions |
| R5486 |
T7947 |
T7949 |
nsubj |
Regions,Represent |
| R5487 |
T7948 |
T7947 |
amod |
Morphologic,Regions |
| R5488 |
T7950 |
T7951 |
det |
the,Sum |
| R5489 |
T7951 |
T7949 |
dobj |
Sum,Represent |
| R5490 |
T7952 |
T7951 |
prep |
of,Sum |
| R5491 |
T7953 |
T7954 |
amod |
Different,Gradients |
| R5492 |
T7954 |
T7952 |
pobj |
Gradients,of |
| R5493 |
T7956 |
T7957 |
det |
The,boundary |
| R5494 |
T7957 |
T7959 |
nsubj |
boundary,is |
| R5495 |
T7958 |
T7957 |
amod |
visual,boundary |
| R5496 |
T7960 |
T7957 |
prep |
between,boundary |
| R5497 |
T7961 |
T7962 |
amod |
dorsal,skin |
| R5498 |
T7962 |
T7960 |
pobj |
skin,between |
| R5499 |
T7963 |
T7961 |
cc |
and,dorsal |
| R5500 |
T7964 |
T7961 |
conj |
ventral,dorsal |
| R5501 |
T7965 |
T7957 |
prep |
in,boundary |
| R5502 |
T7966 |
T7967 |
nmod |
at,at |
| R5503 |
T7967 |
T7969 |
compound |
at,mice |
| R5504 |
T7968 |
T7967 |
punct |
/,at |
| R5505 |
T7969 |
T7965 |
pobj |
mice,in |
| R5506 |
T7970 |
T7959 |
acomp |
reminiscent,is |
| R5507 |
T7971 |
T7970 |
prep |
of,reminiscent |
| R5508 |
T7972 |
T7973 |
amod |
other,systems |
| R5509 |
T7973 |
T7971 |
pobj |
systems,of |
| R5510 |
T7974 |
T7975 |
prep |
in,enforce |
| R5511 |
T7975 |
T7973 |
relcl |
enforce,systems |
| R5512 |
T7976 |
T7974 |
pobj |
which,in |
| R5513 |
T7977 |
T7978 |
amod |
adjacent,compartments |
| R5514 |
T7978 |
T7975 |
nsubj |
compartments,enforce |
| R5515 |
T7979 |
T7980 |
det |
a,choice |
| R5516 |
T7980 |
T7975 |
dobj |
choice,enforce |
| R5517 |
T7981 |
T7980 |
amod |
binary,choice |
| R5518 |
T7982 |
T7980 |
prep |
between,choice |
| R5519 |
T7983 |
T7984 |
amod |
alternative,patterns |
| R5520 |
T7984 |
T7982 |
pobj |
patterns,between |
| R5521 |
T7985 |
T7984 |
prep |
of,patterns |
| R5522 |
T7986 |
T7987 |
compound |
gene,expression |
| R5523 |
T7987 |
T7985 |
pobj |
expression,of |
| R5524 |
T7988 |
T7987 |
cc |
and,expression |
| R5525 |
T7989 |
T7990 |
compound |
cell,fate |
| R5526 |
T7990 |
T7987 |
conj |
fate,expression |
| R5527 |
T7991 |
T7992 |
punct |
(,reviewed |
| R5528 |
T7992 |
T7959 |
parataxis |
reviewed,is |
| R5529 |
T7993 |
T7992 |
prep |
in,reviewed |
| R5530 |
T7994 |
T7993 |
pobj |
Dahmann,in |
| R5531 |
T7995 |
T7994 |
cc |
and,Dahmann |
| R5532 |
T7996 |
T7994 |
conj |
Basler,Dahmann |
| R5533 |
T7997 |
T7994 |
npadvmod |
1999,Dahmann |
| R5534 |
T7998 |
T7992 |
punct |
),reviewed |
| R5535 |
T7999 |
T7959 |
punct |
.,is |
| R5536 |
T8001 |
T8002 |
advmod |
However,distributed |
| R5537 |
T8003 |
T8002 |
punct |
", ",distributed |
| R5538 |
T8004 |
T8005 |
compound |
Agouti,mRNA |
| R5539 |
T8005 |
T8002 |
nsubjpass |
mRNA,distributed |
| R5540 |
T8006 |
T8005 |
prep |
in,mRNA |
| R5541 |
T8007 |
T8008 |
preconj |
both,embryonic |
| R5542 |
T8008 |
T8009 |
amod |
embryonic,skin |
| R5543 |
T8009 |
T8006 |
pobj |
skin,in |
| R5544 |
T8010 |
T8008 |
cc |
and,embryonic |
| R5545 |
T8011 |
T8008 |
conj |
postnatal,embryonic |
| R5546 |
T8012 |
T8002 |
auxpass |
is,distributed |
| R5547 |
T8013 |
T8002 |
prep |
along,distributed |
| R5548 |
T8014 |
T8015 |
det |
a,gradient |
| R5549 |
T8015 |
T8013 |
pobj |
gradient,along |
| R5550 |
T8016 |
T8017 |
poss |
whose,boundary |
| R5551 |
T8017 |
T8019 |
dep |
boundary,is |
| R5552 |
T8018 |
T8017 |
amod |
dorsal,boundary |
| R5553 |
T8019 |
T8015 |
relcl |
is,gradient |
| R5554 |
T8020 |
T8019 |
acomp |
indistinct,is |
| R5555 |
T8021 |
T8019 |
cc |
and,is |
| R5556 |
T8022 |
T8019 |
conj |
overlaps,is |
| R5557 |
T8023 |
T8022 |
prep |
with,overlaps |
| R5558 |
T8024 |
T8025 |
nummod |
two,gradients |
| R5559 |
T8025 |
T8023 |
pobj |
gradients,with |
| R5560 |
T8026 |
T8025 |
amod |
additional,gradients |
| R5561 |
T8027 |
T8025 |
acl |
recognized,gradients |
| R5562 |
T8028 |
T8027 |
prep |
by,recognized |
| R5563 |
T8029 |
T8030 |
poss |
their,effects |
| R5564 |
T8030 |
T8028 |
pobj |
effects,by |
| R5565 |
T8031 |
T8030 |
prep |
on,effects |
| R5566 |
T8032 |
T8033 |
compound |
hair,length |
| R5567 |
T8033 |
T8031 |
pobj |
length,on |
| R5568 |
T8034 |
T8033 |
cc |
and,length |
| R5569 |
T8035 |
T8036 |
amod |
histochemical,staining |
| R5570 |
T8036 |
T8033 |
conj |
staining,length |
| R5571 |
T8037 |
T8002 |
prep |
for,distributed |
| R5572 |
T8038 |
T8037 |
pobj |
melanocytes,for |
| R5573 |
T8039 |
T8002 |
punct |
.,distributed |
| R5574 |
T8041 |
T8042 |
det |
The,gradients |
| R5575 |
T8042 |
T8044 |
nsubj |
gradients,are |
| R5576 |
T8043 |
T8042 |
nummod |
three,gradients |
| R5577 |
T8045 |
T8044 |
acomp |
close,are |
| R5578 |
T8046 |
T8045 |
cc |
but,close |
| R5579 |
T8047 |
T8046 |
neg |
not,but |
| R5580 |
T8048 |
T8045 |
conj |
congruent,close |
| R5581 |
T8049 |
T8044 |
punct |
", ",are |
| R5582 |
T8050 |
T8044 |
cc |
and,are |
| R5583 |
T8051 |
T8052 |
nsubj |
it,is |
| R5584 |
T8052 |
T8044 |
conj |
is,are |
| R5585 |
T8053 |
T8054 |
poss |
their,proximity |
| R5586 |
T8054 |
T8052 |
attr |
proximity,is |
| R5587 |
T8055 |
T8056 |
dep |
that,gives |
| R5588 |
T8056 |
T8052 |
ccomp |
gives,is |
| R5589 |
T8057 |
T8056 |
dobj |
rise,gives |
| R5590 |
T8058 |
T8056 |
prep |
to,gives |
| R5591 |
T8059 |
T8060 |
det |
the,distinction |
| R5592 |
T8060 |
T8058 |
pobj |
distinction,to |
| R5593 |
T8061 |
T8060 |
amod |
superficial,distinction |
| R5594 |
T8062 |
T8060 |
prep |
between,distinction |
| R5595 |
T8063 |
T8064 |
amod |
dorsal,skin |
| R5596 |
T8064 |
T8062 |
pobj |
skin,between |
| R5597 |
T8065 |
T8063 |
cc |
and,dorsal |
| R5598 |
T8066 |
T8063 |
conj |
ventral,dorsal |
| R5599 |
T8067 |
T8064 |
prep |
of,skin |
| R5600 |
T8068 |
T8069 |
nmod |
at,at |
| R5601 |
T8069 |
T8071 |
compound |
at,mice |
| R5602 |
T8070 |
T8069 |
punct |
/,at |
| R5603 |
T8071 |
T8067 |
pobj |
mice,of |
| R5604 |
T8072 |
T8052 |
punct |
.,is |
| R5605 |
T8074 |
T8075 |
advmod |
Indeed,give |
| R5606 |
T8076 |
T8075 |
punct |
", ",give |
| R5607 |
T8077 |
T8078 |
amod |
slight,differences |
| R5608 |
T8078 |
T8075 |
nsubj |
differences,give |
| R5609 |
T8079 |
T8078 |
prep |
between,differences |
| R5610 |
T8080 |
T8081 |
det |
the,regions |
| R5611 |
T8081 |
T8079 |
pobj |
regions,between |
| R5612 |
T8082 |
T8081 |
prep |
of,regions |
| R5613 |
T8083 |
T8082 |
pobj |
transition,of |
| R5614 |
T8084 |
T8081 |
prep |
for,regions |
| R5615 |
T8085 |
T8086 |
compound |
pigment,type |
| R5616 |
T8086 |
T8088 |
compound |
type,switching |
| R5617 |
T8087 |
T8086 |
punct |
-,type |
| R5618 |
T8088 |
T8084 |
pobj |
switching,for |
| R5619 |
T8089 |
T8088 |
cc |
and,switching |
| R5620 |
T8090 |
T8091 |
compound |
pigment,content |
| R5621 |
T8091 |
T8088 |
conj |
content,switching |
| R5622 |
T8092 |
T8075 |
dobj |
rise,give |
| R5623 |
T8093 |
T8075 |
prep |
to,give |
| R5624 |
T8094 |
T8095 |
det |
a,stripe |
| R5625 |
T8095 |
T8093 |
pobj |
stripe,to |
| R5626 |
T8096 |
T8095 |
amod |
subtle,stripe |
| R5627 |
T8097 |
T8095 |
amod |
yellow,stripe |
| R5628 |
T8098 |
T8095 |
prep |
along,stripe |
| R5629 |
T8099 |
T8100 |
det |
the,flank |
| R5630 |
T8100 |
T8098 |
pobj |
flank,along |
| R5631 |
T8101 |
T8102 |
punct |
(,see |
| R5632 |
T8102 |
T8075 |
parataxis |
see,give |
| R5633 |
T8103 |
T8104 |
nmod |
Figures,1 |
| R5634 |
T8104 |
T8102 |
dobj |
1,see |
| R5635 |
T8105 |
T8104 |
punct |
", ",1 |
| R5636 |
T8106 |
T8104 |
conj |
2,1 |
| R5637 |
T8107 |
T8106 |
punct |
", ",2 |
| R5638 |
T8108 |
T8106 |
cc |
and,2 |
| R5639 |
T8109 |
T8106 |
conj |
9A,2 |
| R5640 |
T8110 |
T8102 |
punct |
),see |
| R5641 |
T8111 |
T8075 |
punct |
.,give |
| R5642 |
T8113 |
T8114 |
nsubj |
Levels,remain |
| R5643 |
T8115 |
T8113 |
prep |
of,Levels |
| R5644 |
T8116 |
T8117 |
compound |
Agouti,mRNA |
| R5645 |
T8117 |
T8115 |
pobj |
mRNA,of |
| R5646 |
T8118 |
T8114 |
oprd |
high,remain |
| R5647 |
T8119 |
T8114 |
prep |
throughout,remain |
| R5648 |
T8120 |
T8121 |
det |
the,ventrum |
| R5649 |
T8121 |
T8119 |
pobj |
ventrum,throughout |
| R5650 |
T8122 |
T8121 |
amod |
entire,ventrum |
| R5651 |
T8123 |
T8114 |
punct |
", ",remain |
| R5652 |
T8124 |
T8114 |
cc |
but,remain |
| R5653 |
T8125 |
T8126 |
compound |
hair,content |
| R5654 |
T8126 |
T8128 |
nsubjpass |
content,reduced |
| R5655 |
T8127 |
T8126 |
compound |
pigment,content |
| R5656 |
T8128 |
T8114 |
conj |
reduced,remain |
| R5657 |
T8129 |
T8128 |
auxpass |
is,reduced |
| R5658 |
T8130 |
T8128 |
punct |
", ",reduced |
| R5659 |
T8131 |
T8128 |
advcl |
giving,reduced |
| R5660 |
T8132 |
T8131 |
dobj |
rise,giving |
| R5661 |
T8133 |
T8131 |
prep |
to,giving |
| R5662 |
T8134 |
T8135 |
det |
a,region |
| R5663 |
T8135 |
T8133 |
pobj |
region,to |
| R5664 |
T8136 |
T8137 |
npadvmod |
cream,colored |
| R5665 |
T8137 |
T8135 |
amod |
colored,region |
| R5666 |
T8138 |
T8137 |
punct |
-,colored |
| R5667 |
T8139 |
T8135 |
prep |
in,region |
| R5668 |
T8140 |
T8141 |
det |
the,ventrum |
| R5669 |
T8141 |
T8139 |
pobj |
ventrum,in |
| R5670 |
T8142 |
T8143 |
dep |
that,appear |
| R5671 |
T8143 |
T8135 |
relcl |
appear,region |
| R5672 |
T8144 |
T8143 |
punct |
", ",appear |
| R5673 |
T8145 |
T8143 |
prep |
depending,appear |
| R5674 |
T8146 |
T8145 |
prep |
on,depending |
| R5675 |
T8147 |
T8146 |
pobj |
age,on |
| R5676 |
T8148 |
T8147 |
cc |
and,age |
| R5677 |
T8149 |
T8150 |
amod |
genetic,backgrounds |
| R5678 |
T8150 |
T8147 |
conj |
backgrounds,age |
| R5679 |
T8151 |
T8143 |
punct |
", ",appear |
| R5680 |
T8152 |
T8143 |
aux |
may,appear |
| R5681 |
T8153 |
T8154 |
advmod |
more,distinct |
| R5682 |
T8154 |
T8143 |
oprd |
distinct,appear |
| R5683 |
T8155 |
T8153 |
cc |
or,more |
| R5684 |
T8156 |
T8153 |
conj |
less,more |
| R5685 |
T8157 |
T8154 |
prep |
from,distinct |
| R5686 |
T8158 |
T8159 |
det |
the,stripe |
| R5687 |
T8159 |
T8157 |
pobj |
stripe,from |
| R5688 |
T8160 |
T8159 |
amod |
yellow,stripe |
| R5689 |
T8161 |
T8159 |
compound |
flank,stripe |
| R5690 |
T8162 |
T8128 |
punct |
.,reduced |
| R5691 |
T8164 |
T8165 |
nsubj |
Loss,affects |
| R5692 |
T8165 |
T8168 |
ccomp |
affects,are |
| R5693 |
T8166 |
T8164 |
prep |
of,Loss |
| R5694 |
T8167 |
T8166 |
pobj |
Tbx15,of |
| R5695 |
T8169 |
T8170 |
amod |
dorsoventral,transitions |
| R5696 |
T8170 |
T8165 |
dobj |
transitions,affects |
| R5697 |
T8171 |
T8170 |
prep |
of,transitions |
| R5698 |
T8172 |
T8173 |
compound |
hair,length |
| R5699 |
T8173 |
T8171 |
pobj |
length,of |
| R5700 |
T8174 |
T8170 |
punct |
", ",transitions |
| R5701 |
T8175 |
T8176 |
compound |
pigment,content |
| R5702 |
T8176 |
T8170 |
conj |
content,transitions |
| R5703 |
T8177 |
T8176 |
punct |
", ",content |
| R5704 |
T8178 |
T8176 |
cc |
and,content |
| R5705 |
T8179 |
T8176 |
conj |
expression,content |
| R5706 |
T8180 |
T8179 |
prep |
of,expression |
| R5707 |
T8181 |
T8182 |
det |
the,isoform |
| R5708 |
T8182 |
T8180 |
pobj |
isoform,of |
| R5709 |
T8183 |
T8184 |
amod |
ventral,specific |
| R5710 |
T8184 |
T8182 |
amod |
specific,isoform |
| R5711 |
T8185 |
T8184 |
punct |
-,specific |
| R5712 |
T8186 |
T8182 |
compound |
Agouti,isoform |
| R5713 |
T8187 |
T8168 |
punct |
;,are |
| R5714 |
T8188 |
T8168 |
advmod |
however,are |
| R5715 |
T8189 |
T8168 |
punct |
", ",are |
| R5716 |
T8190 |
T8191 |
det |
the,effects |
| R5717 |
T8191 |
T8168 |
nsubj |
effects,are |
| R5718 |
T8192 |
T8191 |
amod |
former,effects |
| R5719 |
T8193 |
T8191 |
nummod |
two,effects |
| R5720 |
T8194 |
T8168 |
acomp |
subtle,are |
| R5721 |
T8195 |
T8168 |
cc |
and,are |
| R5722 |
T8196 |
T8168 |
conj |
contribute,are |
| R5723 |
T8197 |
T8196 |
dobj |
little,contribute |
| R5724 |
T8198 |
T8199 |
punct |
", ",all |
| R5725 |
T8199 |
T8197 |
parataxis |
all,little |
| R5726 |
T8200 |
T8199 |
mark |
if,all |
| R5727 |
T8201 |
T8199 |
advmod |
at,all |
| R5728 |
T8202 |
T8199 |
punct |
", ",all |
| R5729 |
T8203 |
T8196 |
prep |
to,contribute |
| R5730 |
T8204 |
T8205 |
det |
the,pigmentation |
| R5731 |
T8205 |
T8203 |
pobj |
pigmentation,to |
| R5732 |
T8206 |
T8205 |
amod |
abnormal,pigmentation |
| R5733 |
T8207 |
T8205 |
prep |
of,pigmentation |
| R5734 |
T8208 |
T8209 |
amod |
adult,mice |
| R5735 |
T8209 |
T8207 |
pobj |
mice,of |
| R5736 |
T8210 |
T8211 |
nmod |
deH,deH |
| R5737 |
T8211 |
T8209 |
compound |
deH,mice |
| R5738 |
T8212 |
T8211 |
punct |
/,deH |
| R5739 |
T8213 |
T8168 |
punct |
.,are |
| R5740 |
T8215 |
T8216 |
advmod |
Thus,is |
| R5741 |
T8217 |
T8216 |
punct |
", ",is |
| R5742 |
T8218 |
T8216 |
prep |
despite,is |
| R5743 |
T8219 |
T8220 |
det |
the,pattern |
| R5744 |
T8220 |
T8218 |
pobj |
pattern,despite |
| R5745 |
T8221 |
T8220 |
amod |
abnormal,pattern |
| R5746 |
T8222 |
T8220 |
prep |
of,pattern |
| R5747 |
T8223 |
T8224 |
amod |
dark,skin |
| R5748 |
T8224 |
T8222 |
pobj |
skin,of |
| R5749 |
T8225 |
T8220 |
prep |
in,pattern |
| R5750 |
T8226 |
T8227 |
amod |
neonatal,mice |
| R5751 |
T8227 |
T8225 |
pobj |
mice,in |
| R5752 |
T8228 |
T8229 |
nmod |
deH,deH |
| R5753 |
T8229 |
T8227 |
compound |
deH,mice |
| R5754 |
T8230 |
T8229 |
punct |
/,deH |
| R5755 |
T8231 |
T8232 |
punct |
(,Figure |
| R5756 |
T8232 |
T8220 |
parataxis |
Figure,pattern |
| R5757 |
T8233 |
T8232 |
advmod |
e.g.,Figure |
| R5758 |
T8234 |
T8232 |
punct |
", ",Figure |
| R5759 |
T8235 |
T8232 |
nummod |
2D,Figure |
| R5760 |
T8236 |
T8232 |
punct |
),Figure |
| R5761 |
T8237 |
T8216 |
punct |
", ",is |
| R5762 |
T8238 |
T8239 |
det |
the,feature |
| R5763 |
T8239 |
T8216 |
nsubj |
feature,is |
| R5764 |
T8240 |
T8241 |
advmod |
most,obvious |
| R5765 |
T8241 |
T8239 |
amod |
obvious,feature |
| R5766 |
T8242 |
T8239 |
prep |
in,feature |
| R5767 |
T8243 |
T8242 |
pobj |
adults,in |
| R5768 |
T8244 |
T8245 |
amod |
dorsal,displacement |
| R5769 |
T8245 |
T8216 |
attr |
displacement,is |
| R5770 |
T8246 |
T8245 |
prep |
of,displacement |
| R5771 |
T8247 |
T8248 |
det |
the,boundary |
| R5772 |
T8248 |
T8246 |
pobj |
boundary,of |
| R5773 |
T8249 |
T8248 |
punct |
“,boundary |
| R5774 |
T8250 |
T8248 |
punct |
”,boundary |
| R5775 |
T8251 |
T8248 |
prep |
between,boundary |
| R5776 |
T8252 |
T8253 |
amod |
black,hair |
| R5777 |
T8253 |
T8251 |
pobj |
hair,between |
| R5778 |
T8254 |
T8252 |
cc |
and,black |
| R5779 |
T8255 |
T8252 |
conj |
yellow,black |
| R5780 |
T8256 |
T8257 |
punct |
(,Figure |
| R5781 |
T8257 |
T8216 |
parataxis |
Figure,is |
| R5782 |
T8258 |
T8257 |
nummod |
9A,Figure |
| R5783 |
T8259 |
T8257 |
punct |
),Figure |
| R5784 |
T8260 |
T8216 |
punct |
.,is |