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PMC:314463 / 0-1198 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T169 0-12 JJ denotes Dorsoventral
T171 0-50 sentence denotes Dorsoventral Patterning of the Mouse Coat by Tbx15
T170 13-23 NN denotes Patterning
T172 24-26 IN denotes of
T173 27-30 DT denotes the
T175 31-36 NN denotes Mouse
T174 37-41 NN denotes Coat
T176 42-44 IN denotes by
T177 45-50 NN denotes Tbx15
T178 100-205 sentence denotes Many members of the animal kingdom display coat or skin color differences along their dorsoventral axis.
T179 101-105 JJ denotes Many
T180 106-113 NNS denotes members
T182 114-116 IN denotes of
T183 117-120 DT denotes the
T185 121-127 NN denotes animal
T184 128-135 NN denotes kingdom
T181 136-143 VBP denotes display
T186 144-148 NN denotes coat
T188 149-151 CC denotes or
T189 152-156 NN denotes skin
T190 157-162 NN denotes color
T187 163-174 NNS denotes differences
T191 175-180 IN denotes along
T192 181-186 PRP$ denotes their
T194 187-199 JJ denotes dorsoventral
T193 200-204 NN denotes axis
T195 204-205 . denotes .
T196 205-444 sentence denotes To determine the mechanisms that control regional differences in pigmentation, we have studied how a classical mouse mutation, droopy ear (deH), affects dorsoventral skin characteristics, especially those under control of the Agouti gene.
T197 206-208 TO denotes To
T198 209-218 VB denotes determine
T200 219-222 DT denotes the
T201 223-233 NNS denotes mechanisms
T202 234-238 WDT denotes that
T203 239-246 VBP denotes control
T204 247-255 JJ denotes regional
T205 256-267 NNS denotes differences
T206 268-270 IN denotes in
T207 271-283 NN denotes pigmentation
T208 283-285 , denotes ,
T209 285-287 PRP denotes we
T210 288-292 VBP denotes have
T199 293-300 VBN denotes studied
T211 301-304 WRB denotes how
T213 305-306 DT denotes a
T215 307-316 JJ denotes classical
T216 317-322 NN denotes mouse
T214 323-331 NN denotes mutation
T217 331-333 , denotes ,
T218 333-339 JJ denotes droopy
T219 340-343 NN denotes ear
T220 344-345 -LRB- denotes (
T221 345-348 NN denotes deH
T222 348-349 -RRB- denotes )
T223 349-351 , denotes ,
T212 351-358 VBZ denotes affects
T224 359-371 JJ denotes dorsoventral
T226 372-376 NN denotes skin
T225 377-392 NNS denotes characteristics
T227 392-394 , denotes ,
T228 394-404 RB denotes especially
T229 405-410 DT denotes those
T230 411-416 IN denotes under
T231 417-424 NN denotes control
T232 425-427 IN denotes of
T233 428-431 DT denotes the
T235 432-438 NN denotes Agouti
T234 439-443 NN denotes gene
T236 443-444 . denotes .
T237 444-684 sentence denotes Mice carrying the Agouti allele black-and-tan (at) normally have a sharp boundary between dorsal black hair and yellow ventral hair; the deH mutation raises the pigmentation boundary, producing an apparent dorsal-to-ventral transformation.
T238 445-449 NNS denotes Mice
T240 450-458 VBG denotes carrying
T241 459-462 DT denotes the
T243 463-469 NN denotes Agouti
T242 470-476 NN denotes allele
T244 477-482 NN denotes black
T245 482-483 HYPH denotes -
T246 483-486 CC denotes and
T247 486-487 HYPH denotes -
T248 487-490 NN denotes tan
T249 491-492 -LRB- denotes (
T250 492-494 NN denotes at
T251 494-495 -RRB- denotes )
T252 496-504 RB denotes normally
T239 505-509 VBP denotes have
T254 510-511 DT denotes a
T256 512-517 JJ denotes sharp
T255 518-526 NN denotes boundary
T257 527-534 IN denotes between
T258 535-541 JJ denotes dorsal
T260 542-547 JJ denotes black
T259 548-552 NN denotes hair
T261 553-556 CC denotes and
T262 557-563 JJ denotes yellow
T264 564-571 JJ denotes ventral
T263 572-576 NN denotes hair
T265 576-577 : denotes ;
T266 578-581 DT denotes the
T268 582-585 NN denotes deH
T267 586-594 NN denotes mutation
T253 595-601 VBZ denotes raises
T269 602-605 DT denotes the
T271 606-618 NN denotes pigmentation
T270 619-627 NN denotes boundary
T272 627-629 , denotes ,
T273 629-638 VBG denotes producing
T274 639-641 DT denotes an
T276 642-650 JJ denotes apparent
T277 651-657 JJ denotes dorsal
T278 657-658 HYPH denotes -
T279 658-660 IN denotes to
T280 660-661 HYPH denotes -
T281 661-668 JJ denotes ventral
T275 669-683 NN denotes transformation
T282 683-684 . denotes .
T283 684-911 sentence denotes We identify a 216 kb deletion in deH that removes all but the first exon of the Tbx15 gene, whose embryonic expression in developing mesenchyme correlates with pigmentary and skeletal malformations observed in deH/deH animals.
T284 685-687 PRP denotes We
T285 688-696 VBP denotes identify
T286 697-698 DT denotes a
T288 699-702 CD denotes 216
T289 703-705 NN denotes kb
T287 706-714 NN denotes deletion
T290 715-717 IN denotes in
T291 718-721 NN denotes deH
T292 722-726 WDT denotes that
T293 727-734 VBZ denotes removes
T294 735-738 DT denotes all
T295 739-742 IN denotes but
T296 743-746 DT denotes the
T298 747-752 JJ denotes first
T297 753-757 NN denotes exon
T299 758-760 IN denotes of
T300 761-764 DT denotes the
T302 765-770 NN denotes Tbx15
T301 771-775 NN denotes gene
T303 775-777 , denotes ,
T304 777-782 WP$ denotes whose
T306 783-792 JJ denotes embryonic
T305 793-803 NN denotes expression
T308 804-806 IN denotes in
T309 807-817 VBG denotes developing
T310 818-828 NN denotes mesenchyme
T307 829-839 VBZ denotes correlates
T311 840-844 IN denotes with
T312 845-855 JJ denotes pigmentary
T314 856-859 CC denotes and
T315 860-868 JJ denotes skeletal
T313 869-882 NNS denotes malformations
T316 883-891 VBN denotes observed
T317 892-894 IN denotes in
T318 895-898 NN denotes deH
T320 898-899 HYPH denotes /
T319 899-902 NN denotes deH
T321 903-910 NNS denotes animals
T322 910-911 . denotes .
T323 911-1025 sentence denotes Construction of a targeted allele of Tbx15 confirmed that the deH phenotype was caused by Tbx15 loss of function.
T324 912-924 NN denotes Construction
T326 925-927 IN denotes of
T327 928-929 DT denotes a
T329 930-938 VBN denotes targeted
T328 939-945 NN denotes allele
T330 946-948 IN denotes of
T331 949-954 NN denotes Tbx15
T325 955-964 VBD denotes confirmed
T332 965-969 IN denotes that
T334 970-973 DT denotes the
T336 974-977 NN denotes deH
T335 978-987 NN denotes phenotype
T337 988-991 VBD denotes was
T333 992-998 VBN denotes caused
T338 999-1001 IN denotes by
T339 1002-1007 NN denotes Tbx15
T340 1008-1012 NN denotes loss
T341 1013-1015 IN denotes of
T342 1016-1024 NN denotes function
T343 1024-1025 . denotes .
T345 1026-1031 RB denotes Early
T346 1032-1041 JJ denotes embryonic
T347 1042-1052 NN denotes expression
T349 1053-1055 IN denotes of
T350 1056-1061 NN denotes Tbx15
T351 1062-1064 IN denotes in
T352 1065-1071 JJ denotes dorsal
T353 1072-1082 NN denotes mesenchyme
T348 1083-1085 VBZ denotes is
T355 1086-1099 JJ denotes complementary
T356 1100-1102 IN denotes to
T357 1103-1109 NN denotes Agouti
T358 1110-1120 NN denotes expression
T359 1121-1123 IN denotes in
T360 1124-1131 JJ denotes ventral
T361 1132-1142 NN denotes mesenchyme
T362 1142-1143 : denotes ;
T363 1144-1146 IN denotes in
T364 1147-1150 DT denotes the
T365 1151-1158 NN denotes absence
T366 1159-1161 IN denotes of
T367 1162-1167 NN denotes Tbx15
T368 1167-1169 , denotes ,
T369 1169-1179 NN denotes expression
T370 1180-1182 IN denotes of
T371 1183-1189 NN denotes Agouti
T372 1190-1192 IN denotes in
T373 1193-1197 CC denotes both
R1 T172 T170 prep of,Patterning
R10 T183 T184 det the,kingdom
R100 T277 T275 amod dorsal,transformation
R101 T278 T277 punct -,dorsal
R102 T279 T277 prep to,dorsal
R103 T280 T279 punct -,to
R104 T281 T279 amod ventral,to
R105 T282 T253 punct .,raises
R106 T284 T285 nsubj We,identify
R107 T286 T287 det a,deletion
R108 T287 T285 dobj deletion,identify
R109 T288 T289 nummod 216,kb
R11 T184 T182 pobj kingdom,of
R110 T289 T287 compound kb,deletion
R111 T290 T287 prep in,deletion
R112 T291 T290 pobj deH,in
R113 T292 T293 dep that,removes
R114 T293 T287 relcl removes,deletion
R115 T294 T293 dobj all,removes
R116 T295 T294 prep but,all
R117 T296 T297 det the,exon
R118 T297 T295 pobj exon,but
R119 T298 T297 amod first,exon
R12 T185 T184 compound animal,kingdom
R120 T299 T297 prep of,exon
R121 T300 T301 det the,gene
R122 T301 T299 pobj gene,of
R123 T302 T301 compound Tbx15,gene
R124 T303 T297 punct ", ",exon
R125 T304 T305 poss whose,expression
R126 T305 T307 dep expression,correlates
R127 T306 T305 amod embryonic,expression
R128 T307 T297 relcl correlates,exon
R129 T308 T305 prep in,expression
R13 T186 T187 nmod coat,differences
R130 T309 T310 amod developing,mesenchyme
R131 T310 T308 pobj mesenchyme,in
R132 T311 T307 prep with,correlates
R133 T312 T313 amod pigmentary,malformations
R134 T313 T311 pobj malformations,with
R135 T314 T312 cc and,pigmentary
R136 T315 T312 conj skeletal,pigmentary
R137 T316 T313 acl observed,malformations
R138 T317 T316 prep in,observed
R139 T318 T319 compound deH,deH
R14 T187 T181 dobj differences,display
R140 T319 T321 compound deH,animals
R141 T320 T319 punct /,deH
R142 T321 T317 pobj animals,in
R143 T322 T285 punct .,identify
R144 T324 T325 nsubj Construction,confirmed
R145 T326 T324 prep of,Construction
R146 T327 T328 det a,allele
R147 T328 T326 pobj allele,of
R148 T329 T328 amod targeted,allele
R149 T330 T328 prep of,allele
R15 T188 T186 cc or,coat
R150 T331 T330 pobj Tbx15,of
R151 T332 T333 mark that,caused
R152 T333 T325 ccomp caused,confirmed
R153 T334 T335 det the,phenotype
R154 T335 T333 nsubjpass phenotype,caused
R155 T336 T335 compound deH,phenotype
R156 T337 T333 auxpass was,caused
R157 T338 T333 agent by,caused
R158 T339 T340 compound Tbx15,loss
R159 T340 T338 pobj loss,by
R16 T189 T190 compound skin,color
R160 T341 T340 prep of,loss
R161 T342 T341 pobj function,of
R162 T343 T325 punct .,confirmed
R163 T345 T346 advmod Early,embryonic
R164 T346 T347 amod embryonic,expression
R165 T347 T348 nsubj expression,is
R167 T349 T347 prep of,expression
R168 T350 T349 pobj Tbx15,of
R169 T351 T347 prep in,expression
R17 T190 T186 conj color,coat
R170 T352 T353 amod dorsal,mesenchyme
R171 T353 T351 pobj mesenchyme,in
R172 T355 T348 acomp complementary,is
R173 T356 T355 prep to,complementary
R174 T357 T358 compound Agouti,expression
R175 T358 T356 pobj expression,to
R176 T359 T358 prep in,expression
R177 T360 T361 amod ventral,mesenchyme
R178 T361 T359 pobj mesenchyme,in
R18 T191 T181 prep along,display
R181 T364 T365 det the,absence
R182 T365 T363 pobj absence,in
R183 T366 T365 prep of,absence
R184 T367 T366 pobj Tbx15,of
R187 T370 T369 prep of,expression
R188 T371 T370 pobj Agouti,of
R189 T372 T369 prep in,expression
R19 T192 T193 poss their,axis
R2 T173 T174 det the,Coat
R20 T193 T191 pobj axis,along
R21 T194 T193 amod dorsoventral,axis
R22 T195 T181 punct .,display
R23 T197 T198 aux To,determine
R24 T198 T199 advcl determine,studied
R25 T200 T201 det the,mechanisms
R26 T201 T198 dobj mechanisms,determine
R27 T202 T203 dep that,control
R28 T203 T201 relcl control,mechanisms
R29 T204 T205 amod regional,differences
R3 T174 T172 pobj Coat,of
R30 T205 T203 dobj differences,control
R31 T206 T205 prep in,differences
R32 T207 T206 pobj pigmentation,in
R325 T169 T170 amod Dorsoventral,Patterning
R33 T208 T199 punct ", ",studied
R34 T209 T199 nsubj we,studied
R35 T210 T199 aux have,studied
R36 T211 T212 advmod how,affects
R37 T212 T199 ccomp affects,studied
R38 T213 T214 det a,mutation
R39 T214 T212 nsubj mutation,affects
R4 T175 T174 compound Mouse,Coat
R40 T215 T214 amod classical,mutation
R41 T216 T214 compound mouse,mutation
R42 T217 T214 punct ", ",mutation
R43 T218 T219 amod droopy,ear
R44 T219 T214 appos ear,mutation
R45 T220 T219 punct (,ear
R46 T221 T219 appos deH,ear
R47 T222 T219 punct ),ear
R48 T223 T212 punct ", ",affects
R49 T224 T225 amod dorsoventral,characteristics
R5 T176 T170 prep by,Patterning
R50 T225 T212 dobj characteristics,affects
R51 T226 T225 compound skin,characteristics
R52 T227 T225 punct ", ",characteristics
R53 T228 T229 advmod especially,those
R54 T229 T225 appos those,characteristics
R55 T230 T229 prep under,those
R56 T231 T230 pobj control,under
R57 T232 T231 prep of,control
R58 T233 T234 det the,gene
R59 T234 T232 pobj gene,of
R6 T177 T176 pobj Tbx15,by
R60 T235 T234 compound Agouti,gene
R61 T236 T199 punct .,studied
R62 T238 T239 nsubj Mice,have
R63 T239 T253 ccomp have,raises
R64 T240 T238 acl carrying,Mice
R65 T241 T242 det the,allele
R66 T242 T240 dobj allele,carrying
R67 T243 T242 compound Agouti,allele
R68 T244 T242 appos black,allele
R69 T245 T244 punct -,black
R7 T179 T180 amod Many,members
R70 T246 T244 cc and,black
R71 T247 T248 punct -,tan
R72 T248 T244 conj tan,black
R73 T249 T244 punct (,black
R74 T250 T244 appos at,black
R75 T251 T239 punct ),have
R76 T252 T239 advmod normally,have
R77 T254 T255 det a,boundary
R78 T255 T239 dobj boundary,have
R79 T256 T255 amod sharp,boundary
R8 T180 T181 nsubj members,display
R80 T257 T255 prep between,boundary
R81 T258 T259 amod dorsal,hair
R82 T259 T257 pobj hair,between
R83 T260 T259 amod black,hair
R84 T261 T259 cc and,hair
R85 T262 T263 amod yellow,hair
R86 T263 T259 conj hair,hair
R87 T264 T263 amod ventral,hair
R88 T265 T253 punct ;,raises
R89 T266 T267 det the,mutation
R9 T182 T180 prep of,members
R90 T267 T253 nsubj mutation,raises
R91 T268 T267 compound deH,mutation
R92 T269 T270 det the,boundary
R93 T270 T253 dobj boundary,raises
R94 T271 T270 compound pigmentation,boundary
R95 T272 T253 punct ", ",raises
R96 T273 T253 advcl producing,raises
R97 T274 T275 det an,transformation
R98 T275 T273 dobj transformation,producing
R99 T276 T275 amod apparent,transformation