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PMC:1941754 / 5678-6544 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1163 0-4 NN denotes PCH2
T1165 4-6 , denotes ,
T1166 6-14 VBG denotes encoding
T1167 15-16 DT denotes a
T1169 17-26 JJ denotes nucleolar
T1171 26-27 HYPH denotes -
T1170 27-36 VBN denotes localized
T1172 37-40 NN denotes AAA
T1173 40-41 HYPH denotes -
T1168 41-47 NN denotes ATPase
T1174 48-52 WDT denotes that
T1176 53-56 VBD denotes was
T1177 57-67 RB denotes originally
T1175 68-78 VBN denotes identified
T1178 79-81 IN denotes in
T1179 82-84 DT denotes an
T1181 85-87 NNP denotes S.
T1182 88-98 NNP denotes cerevisiae
T1183 99-106 JJ denotes genetic
T1180 107-113 NN denotes screen
T1184 114-117 IN denotes for
T1185 118-125 NNS denotes mutants
T1186 126-130 WDT denotes that
T1187 131-138 VBP denotes relieve
T1188 139-148 NN denotes pachytene
T1189 149-155 NN denotes arrest
T1190 156-158 IN denotes of
T1191 159-168 JJ denotes asynaptic
T1193 169-173 NN denotes zip1
T1192 174-181 NNS denotes mutants
T1194 182-183 -LRB- denotes [
T1195 183-184 CD denotes 8
T1196 184-185 -RRB- denotes ]
T1197 185-187 , denotes ,
T1198 187-190 VBD denotes was
T1199 191-199 RB denotes recently
T1164 200-210 VBN denotes determined
T1200 211-213 TO denotes to
T1201 214-216 VB denotes be
T1202 217-219 DT denotes an
T1204 220-229 JJ denotes essential
T1203 230-239 NN denotes component
T1205 240-242 IN denotes of
T1206 243-246 DT denotes the
T1208 247-256 NN denotes pachytene
T1209 257-265 NN denotes synapsis
T1210 266-267 -LRB- denotes (
T1211 267-270 CC denotes but
T1212 271-274 RB denotes not
T1213 275-278 NN denotes DSB
T1214 279-285 NN denotes repair
T1215 285-286 -RRB- denotes )
T1207 287-297 NN denotes checkpoint
T1216 298-300 IN denotes in
T1217 301-306 NN denotes yeast
T1218 307-310 CC denotes and
T1219 311-316 NNS denotes worms
T1220 317-318 -LRB- denotes [
T1222 318-319 CD denotes 2
T1223 319-320 , denotes ,
T1221 320-322 CD denotes 12
T1224 322-323 -RRB- denotes ]
T1225 323-324 . denotes .
T1226 324-560 sentence denotes PCH2 orthologs are present in organisms that undergo synaptic meiosis, but not asynaptic meiosis, prompting the suggestion that a Pch2-dependent checkpoint evolved to monitor synaptonemal complex (SC) defects from yeast to humans [12].
T1227 325-329 NN denotes PCH2
T1228 330-339 NNS denotes orthologs
T1229 340-343 VBP denotes are
T1230 344-351 JJ denotes present
T1231 352-354 IN denotes in
T1232 355-364 NNS denotes organisms
T1233 365-369 WDT denotes that
T1234 370-377 VBP denotes undergo
T1235 378-386 JJ denotes synaptic
T1236 387-394 NN denotes meiosis
T1237 394-396 , denotes ,
T1238 396-399 CC denotes but
T1239 400-403 RB denotes not
T1240 404-413 JJ denotes asynaptic
T1241 414-421 NN denotes meiosis
T1242 421-423 , denotes ,
T1243 423-432 VBG denotes prompting
T1244 433-436 DT denotes the
T1245 437-447 NN denotes suggestion
T1246 448-452 IN denotes that
T1248 453-454 DT denotes a
T1250 455-459 NN denotes Pch2
T1252 459-460 HYPH denotes -
T1251 460-469 JJ denotes dependent
T1249 470-480 NN denotes checkpoint
T1247 481-488 VBD denotes evolved
T1253 489-491 TO denotes to
T1254 492-499 VB denotes monitor
T1255 500-512 JJ denotes synaptonemal
T1256 513-520 NN denotes complex
T1258 521-522 -LRB- denotes (
T1259 522-524 NN denotes SC
T1260 524-525 -RRB- denotes )
T1257 526-533 NNS denotes defects
T1261 534-538 IN denotes from
T1262 539-544 NN denotes yeast
T1263 545-547 IN denotes to
T1264 548-554 NNS denotes humans
T1265 555-556 -LRB- denotes [
T1266 556-558 CD denotes 12
T1267 558-559 -RRB- denotes ]
T1268 559-560 . denotes .
T1269 560-704 sentence denotes Here, we generated mice deficient for the Trip13, the ortholog of PCH2, and evaluated whether it also plays a role in the pachytene checkpoint.
T1270 561-565 RB denotes Here
T1272 565-567 , denotes ,
T1273 567-569 PRP denotes we
T1271 570-579 VBD denotes generated
T1274 580-584 NNS denotes mice
T1275 585-594 JJ denotes deficient
T1276 595-598 IN denotes for
T1277 599-602 DT denotes the
T1278 603-609 NN denotes Trip13
T1279 609-611 , denotes ,
T1280 611-614 DT denotes the
T1281 615-623 NN denotes ortholog
T1282 624-626 IN denotes of
T1283 627-631 NN denotes PCH2
T1284 631-633 , denotes ,
T1285 633-636 CC denotes and
T1286 637-646 VBD denotes evaluated
T1287 647-654 IN denotes whether
T1289 655-657 PRP denotes it
T1290 658-662 RB denotes also
T1288 663-668 VBZ denotes plays
T1291 669-670 DT denotes a
T1292 671-675 NN denotes role
T1293 676-678 IN denotes in
T1294 679-682 DT denotes the
T1296 683-692 NN denotes pachytene
T1295 693-703 NN denotes checkpoint
T1297 703-704 . denotes .
T1298 704-865 sentence denotes Surprisingly, while we found no evidence for checkpoint function, we did uncover a potential role for this protein in noncrossover (NCO) repair of meiotic DSBs.
T1299 705-717 RB denotes Surprisingly
T1301 717-719 , denotes ,
T1302 719-724 IN denotes while
T1304 725-727 PRP denotes we
T1303 728-733 VBD denotes found
T1305 734-736 DT denotes no
T1306 737-745 NN denotes evidence
T1307 746-749 IN denotes for
T1308 750-760 NN denotes checkpoint
T1309 761-769 NN denotes function
T1310 769-771 , denotes ,
T1311 771-773 PRP denotes we
T1312 774-777 VBD denotes did
T1300 778-785 VB denotes uncover
T1313 786-787 DT denotes a
T1315 788-797 JJ denotes potential
T1314 798-802 NN denotes role
T1316 803-806 IN denotes for
T1317 807-811 DT denotes this
T1318 812-819 NN denotes protein
T1319 820-822 IN denotes in
T1320 823-835 JJ denotes noncrossover
T1322 836-837 -LRB- denotes (
T1321 837-840 JJ denotes NCO
T1324 840-841 -RRB- denotes )
T1323 842-848 NN denotes repair
T1325 849-851 IN denotes of
T1326 852-859 JJ denotes meiotic
T1327 860-864 NNS denotes DSBs
T1328 864-865 . denotes .
R716 T1163 T1164 nsubjpass PCH2,determined
R717 T1165 T1163 punct ", ",PCH2
R718 T1166 T1163 acl encoding,PCH2
R719 T1167 T1168 det a,ATPase
R720 T1168 T1166 dobj ATPase,encoding
R721 T1169 T1170 amod nucleolar,localized
R722 T1170 T1168 amod localized,ATPase
R723 T1171 T1170 punct -,localized
R724 T1172 T1168 compound AAA,ATPase
R725 T1173 T1168 punct -,ATPase
R726 T1174 T1175 dep that,identified
R727 T1175 T1166 ccomp identified,encoding
R728 T1176 T1175 auxpass was,identified
R729 T1177 T1175 advmod originally,identified
R730 T1178 T1175 prep in,identified
R731 T1179 T1180 det an,screen
R732 T1180 T1178 pobj screen,in
R733 T1181 T1182 nmod S.,cerevisiae
R734 T1182 T1180 nmod cerevisiae,screen
R735 T1183 T1180 amod genetic,screen
R736 T1184 T1175 prep for,identified
R737 T1185 T1184 pobj mutants,for
R738 T1186 T1187 dep that,relieve
R739 T1187 T1185 relcl relieve,mutants
R740 T1188 T1189 compound pachytene,arrest
R741 T1189 T1187 dobj arrest,relieve
R742 T1190 T1189 prep of,arrest
R743 T1191 T1192 amod asynaptic,mutants
R744 T1192 T1190 pobj mutants,of
R745 T1193 T1192 compound zip1,mutants
R746 T1194 T1195 punct [,8
R747 T1195 T1175 parataxis 8,identified
R748 T1196 T1195 punct ],8
R749 T1197 T1164 punct ", ",determined
R750 T1198 T1164 auxpass was,determined
R751 T1199 T1164 advmod recently,determined
R752 T1200 T1201 aux to,be
R753 T1201 T1164 xcomp be,determined
R754 T1202 T1203 det an,component
R755 T1203 T1201 attr component,be
R756 T1204 T1203 amod essential,component
R757 T1205 T1203 prep of,component
R758 T1206 T1207 det the,checkpoint
R759 T1207 T1205 pobj checkpoint,of
R760 T1208 T1209 nmod pachytene,synapsis
R761 T1209 T1207 nmod synapsis,checkpoint
R762 T1210 T1209 punct (,synapsis
R763 T1211 T1209 cc but,synapsis
R764 T1212 T1211 neg not,but
R765 T1213 T1214 compound DSB,repair
R766 T1214 T1209 conj repair,synapsis
R767 T1215 T1207 punct ),checkpoint
R768 T1216 T1207 prep in,checkpoint
R769 T1217 T1216 pobj yeast,in
R770 T1218 T1217 cc and,yeast
R771 T1219 T1217 conj worms,yeast
R772 T1220 T1221 punct [,12
R773 T1221 T1164 parataxis 12,determined
R774 T1222 T1221 nummod 2,12
R775 T1223 T1221 punct ",",12
R776 T1224 T1221 punct ],12
R777 T1225 T1164 punct .,determined
R778 T1227 T1228 compound PCH2,orthologs
R779 T1228 T1229 nsubj orthologs,are
R780 T1230 T1229 acomp present,are
R781 T1231 T1229 prep in,are
R782 T1232 T1231 pobj organisms,in
R783 T1233 T1234 dep that,undergo
R784 T1234 T1232 relcl undergo,organisms
R785 T1235 T1236 amod synaptic,meiosis
R786 T1236 T1234 dobj meiosis,undergo
R787 T1237 T1236 punct ", ",meiosis
R788 T1238 T1236 cc but,meiosis
R789 T1239 T1238 neg not,but
R790 T1240 T1241 amod asynaptic,meiosis
R791 T1241 T1236 conj meiosis,meiosis
R792 T1242 T1229 punct ", ",are
R793 T1243 T1229 advcl prompting,are
R794 T1244 T1245 det the,suggestion
R795 T1245 T1243 dobj suggestion,prompting
R796 T1246 T1247 mark that,evolved
R797 T1247 T1245 acl evolved,suggestion
R798 T1248 T1249 det a,checkpoint
R799 T1249 T1247 nsubj checkpoint,evolved
R800 T1250 T1251 npadvmod Pch2,dependent
R801 T1251 T1249 amod dependent,checkpoint
R802 T1252 T1251 punct -,dependent
R803 T1253 T1254 aux to,monitor
R804 T1254 T1247 advcl monitor,evolved
R805 T1255 T1256 amod synaptonemal,complex
R806 T1256 T1257 nmod complex,defects
R807 T1257 T1254 dobj defects,monitor
R808 T1258 T1256 punct (,complex
R809 T1259 T1256 appos SC,complex
R810 T1260 T1257 punct ),defects
R811 T1261 T1257 prep from,defects
R812 T1262 T1261 pobj yeast,from
R813 T1263 T1257 prep to,defects
R814 T1264 T1263 pobj humans,to
R815 T1265 T1266 punct [,12
R816 T1266 T1229 parataxis 12,are
R817 T1267 T1266 punct ],12
R818 T1268 T1229 punct .,are
R819 T1270 T1271 advmod Here,generated
R820 T1272 T1271 punct ", ",generated
R821 T1273 T1271 nsubj we,generated
R822 T1274 T1271 dobj mice,generated
R823 T1275 T1274 amod deficient,mice
R824 T1276 T1275 prep for,deficient
R825 T1277 T1278 det the,Trip13
R826 T1278 T1276 pobj Trip13,for
R827 T1279 T1278 punct ", ",Trip13
R828 T1280 T1281 det the,ortholog
R829 T1281 T1278 appos ortholog,Trip13
R830 T1282 T1281 prep of,ortholog
R831 T1283 T1282 pobj PCH2,of
R832 T1284 T1271 punct ", ",generated
R833 T1285 T1271 cc and,generated
R834 T1286 T1271 conj evaluated,generated
R835 T1287 T1288 mark whether,plays
R836 T1288 T1286 ccomp plays,evaluated
R837 T1289 T1288 nsubj it,plays
R838 T1290 T1288 advmod also,plays
R839 T1291 T1292 det a,role
R840 T1292 T1288 dobj role,plays
R841 T1293 T1288 prep in,plays
R842 T1294 T1295 det the,checkpoint
R843 T1295 T1293 pobj checkpoint,in
R844 T1296 T1295 compound pachytene,checkpoint
R845 T1297 T1271 punct .,generated
R846 T1299 T1300 advmod Surprisingly,uncover
R847 T1301 T1300 punct ", ",uncover
R848 T1302 T1303 mark while,found
R849 T1303 T1300 advcl found,uncover
R850 T1304 T1303 nsubj we,found
R851 T1305 T1306 det no,evidence
R852 T1306 T1303 dobj evidence,found
R853 T1307 T1303 prep for,found
R854 T1308 T1309 compound checkpoint,function
R855 T1309 T1307 pobj function,for
R856 T1310 T1300 punct ", ",uncover
R857 T1311 T1300 nsubj we,uncover
R858 T1312 T1300 aux did,uncover
R859 T1313 T1314 det a,role
R860 T1314 T1300 dobj role,uncover
R861 T1315 T1314 amod potential,role
R862 T1316 T1314 prep for,role
R863 T1317 T1318 det this,protein
R864 T1318 T1316 pobj protein,for
R865 T1319 T1314 prep in,role
R866 T1320 T1321 amod noncrossover,NCO
R867 T1321 T1323 amod NCO,repair
R868 T1322 T1321 punct (,NCO
R869 T1323 T1319 pobj repair,in
R870 T1324 T1323 punct ),repair
R871 T1325 T1323 prep of,repair
R872 T1326 T1327 amod meiotic,DSBs
R873 T1327 T1325 pobj DSBs,of
R874 T1328 T1300 punct .,uncover