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PMC:1941754 / 34627-35384 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T7294 0-9 VBG denotes Regarding
T7296 10-13 DT denotes the
T7297 14-19 NN denotes cause
T7298 20-22 IN denotes of
T7299 23-27 NN denotes cell
T7300 28-33 NN denotes death
T7301 34-36 IN denotes in
T7302 37-43 NN denotes Trip13
T7303 44-51 NNS denotes mutants
T7304 51-53 , denotes ,
T7305 53-56 PRP$ denotes our
T7306 57-61 NNS denotes data
T7295 62-70 VBP denotes indicate
T7307 71-75 IN denotes that
T7309 76-80 DT denotes this
T7310 81-83 VBZ denotes is
T7308 84-93 VBN denotes triggered
T7311 94-96 IN denotes by
T7312 97-106 JJ denotes defective
T7314 107-110 NN denotes DSB
T7313 111-117 NN denotes repair
T7315 118-124 RB denotes rather
T7316 125-129 IN denotes than
T7317 130-139 NN denotes asynapsis
T7318 139-140 . denotes .
T7319 140-301 sentence denotes We base this conclusion on two observations: (1) oocyte elimination is dependent upon DSB formation and (2) synapsis is normal in spermatocytes of adult testes.
T7320 141-143 PRP denotes We
T7321 144-148 VBP denotes base
T7323 149-153 DT denotes this
T7324 154-164 NN denotes conclusion
T7325 165-167 IN denotes on
T7326 168-171 CD denotes two
T7327 172-184 NNS denotes observations
T7328 184-186 : denotes :
T7329 186-187 -LRB- denotes (
T7330 187-188 LS denotes 1
T7331 188-189 -RRB- denotes )
T7332 190-196 NN denotes oocyte
T7333 197-208 NN denotes elimination
T7322 209-211 VBZ denotes is
T7334 212-221 JJ denotes dependent
T7335 222-226 IN denotes upon
T7336 227-230 NN denotes DSB
T7337 231-240 NN denotes formation
T7338 241-244 CC denotes and
T7339 245-246 -LRB- denotes (
T7340 246-247 LS denotes 2
T7342 247-248 -RRB- denotes )
T7343 249-257 NN denotes synapsis
T7341 258-260 VBZ denotes is
T7344 261-267 JJ denotes normal
T7345 268-270 IN denotes in
T7346 271-284 NNS denotes spermatocytes
T7347 285-287 IN denotes of
T7348 288-293 JJ denotes adult
T7349 294-300 NNS denotes testes
T7350 300-301 . denotes .
T7351 301-425 sentence denotes Indeed, this mutant is unique in that recombination defects occur in the absence of asynapsis (e.g., as in Dmc1 knockouts).
T7352 302-308 RB denotes Indeed
T7354 308-310 , denotes ,
T7355 310-314 DT denotes this
T7356 315-321 NN denotes mutant
T7353 322-324 VBZ denotes is
T7357 325-331 JJ denotes unique
T7358 332-334 IN denotes in
T7360 335-339 IN denotes that
T7361 340-353 NN denotes recombination
T7362 354-361 NNS denotes defects
T7359 362-367 VBP denotes occur
T7363 368-370 IN denotes in
T7364 371-374 DT denotes the
T7365 375-382 NN denotes absence
T7366 383-385 IN denotes of
T7367 386-395 NN denotes asynapsis
T7368 396-397 -LRB- denotes (
T7370 397-401 FW denotes e.g.
T7371 401-403 , denotes ,
T7369 403-405 IN denotes as
T7372 406-408 IN denotes in
T7373 409-413 NN denotes Dmc1
T7374 414-423 NNS denotes knockouts
T7375 423-424 -RRB- denotes )
T7376 424-425 . denotes .
T7377 425-567 sentence denotes Thus, the Trip13 mutant provides the first evidence that unrepaired DNA damage alone can trigger the mammalian pachytene checkpoint response.
T7378 426-430 RB denotes Thus
T7380 430-432 , denotes ,
T7381 432-435 DT denotes the
T7383 436-442 NN denotes Trip13
T7382 443-449 NN denotes mutant
T7379 450-458 VBZ denotes provides
T7384 459-462 DT denotes the
T7386 463-468 JJ denotes first
T7385 469-477 NN denotes evidence
T7387 478-482 IN denotes that
T7389 483-493 JJ denotes unrepaired
T7391 494-497 NN denotes DNA
T7390 498-504 NN denotes damage
T7392 505-510 RB denotes alone
T7393 511-514 MD denotes can
T7388 515-522 VB denotes trigger
T7394 523-526 DT denotes the
T7396 527-536 JJ denotes mammalian
T7397 537-546 NN denotes pachytene
T7398 547-557 NN denotes checkpoint
T7395 558-566 NN denotes response
T7399 566-567 . denotes .
T7400 567-757 sentence denotes Furthermore, our results allow us to conclude that oocytes and spermatocytes share a similar, if not identical, DNA damage pachytene checkpoint that is decoupled from a synapsis checkpoint.
T7401 568-579 RB denotes Furthermore
T7403 579-581 , denotes ,
T7404 581-584 PRP$ denotes our
T7405 585-592 NNS denotes results
T7402 593-598 VBP denotes allow
T7406 599-601 PRP denotes us
T7408 602-604 TO denotes to
T7407 605-613 VB denotes conclude
T7409 614-618 IN denotes that
T7411 619-626 NNS denotes oocytes
T7412 627-630 CC denotes and
T7413 631-644 NNS denotes spermatocytes
T7410 645-650 VBP denotes share
T7414 651-652 DT denotes a
T7416 653-660 JJ denotes similar
T7417 660-662 , denotes ,
T7418 662-664 IN denotes if
T7419 665-668 RB denotes not
T7420 669-678 JJ denotes identical
T7421 678-680 , denotes ,
T7422 680-683 NN denotes DNA
T7423 684-690 NN denotes damage
T7424 691-700 NN denotes pachytene
T7415 701-711 NN denotes checkpoint
T7425 712-716 WDT denotes that
T7427 717-719 VBZ denotes is
T7426 720-729 VBN denotes decoupled
T7428 730-734 IN denotes from
T7429 735-736 DT denotes a
T7431 737-745 NN denotes synapsis
T7430 746-756 NN denotes checkpoint
T7432 756-757 . denotes .
R4680 T7294 T7295 prep Regarding,indicate
R4681 T7296 T7297 det the,cause
R4682 T7297 T7294 pobj cause,Regarding
R4683 T7298 T7297 prep of,cause
R4684 T7299 T7300 compound cell,death
R4685 T7300 T7298 pobj death,of
R4686 T7301 T7300 prep in,death
R4687 T7302 T7303 compound Trip13,mutants
R4688 T7303 T7301 pobj mutants,in
R4689 T7304 T7295 punct ", ",indicate
R4690 T7305 T7306 poss our,data
R4691 T7306 T7295 nsubj data,indicate
R4692 T7307 T7308 mark that,triggered
R4693 T7308 T7295 ccomp triggered,indicate
R4694 T7309 T7308 nsubjpass this,triggered
R4695 T7310 T7308 auxpass is,triggered
R4696 T7311 T7308 agent by,triggered
R4697 T7312 T7313 amod defective,repair
R4698 T7313 T7311 pobj repair,by
R4699 T7314 T7313 compound DSB,repair
R4700 T7315 T7316 advmod rather,than
R4701 T7316 T7313 prep than,repair
R4702 T7317 T7316 pobj asynapsis,than
R4703 T7318 T7295 punct .,indicate
R4704 T7320 T7321 nsubj We,base
R4705 T7321 T7322 ccomp base,is
R4706 T7323 T7324 det this,conclusion
R4707 T7324 T7321 dobj conclusion,base
R4708 T7325 T7324 prep on,conclusion
R4709 T7326 T7327 nummod two,observations
R4710 T7327 T7325 pobj observations,on
R4711 T7328 T7322 punct : ,is
R4712 T7329 T7330 punct (,1
R4713 T7330 T7322 meta 1,is
R4714 T7331 T7330 punct ),1
R4715 T7332 T7333 compound oocyte,elimination
R4716 T7333 T7322 nsubj elimination,is
R4717 T7334 T7322 acomp dependent,is
R4718 T7335 T7334 prep upon,dependent
R4719 T7336 T7337 compound DSB,formation
R4720 T7337 T7335 pobj formation,upon
R4721 T7338 T7322 cc and,is
R4722 T7339 T7340 punct (,2
R4723 T7340 T7341 meta 2,is
R4724 T7341 T7322 conj is,is
R4725 T7342 T7340 punct ),2
R4726 T7343 T7341 nsubj synapsis,is
R4727 T7344 T7341 acomp normal,is
R4728 T7345 T7341 prep in,is
R4729 T7346 T7345 pobj spermatocytes,in
R4730 T7347 T7346 prep of,spermatocytes
R4731 T7348 T7349 amod adult,testes
R4732 T7349 T7347 pobj testes,of
R4733 T7350 T7322 punct .,is
R4734 T7352 T7353 advmod Indeed,is
R4735 T7354 T7353 punct ", ",is
R4736 T7355 T7356 det this,mutant
R4737 T7356 T7353 nsubj mutant,is
R4738 T7357 T7353 acomp unique,is
R4739 T7358 T7359 mark in,occur
R4740 T7359 T7353 advcl occur,is
R4741 T7360 T7359 mark that,occur
R4742 T7361 T7362 compound recombination,defects
R4743 T7362 T7359 nsubj defects,occur
R4744 T7363 T7359 prep in,occur
R4745 T7364 T7365 det the,absence
R4746 T7365 T7363 pobj absence,in
R4747 T7366 T7365 prep of,absence
R4748 T7367 T7366 pobj asynapsis,of
R4749 T7368 T7369 punct (,as
R4750 T7369 T7359 parataxis as,occur
R4751 T7370 T7369 advmod e.g.,as
R4752 T7371 T7369 punct ", ",as
R4753 T7372 T7369 prep in,as
R4754 T7373 T7374 compound Dmc1,knockouts
R4755 T7374 T7372 pobj knockouts,in
R4756 T7375 T7369 punct ),as
R4757 T7376 T7353 punct .,is
R4758 T7378 T7379 advmod Thus,provides
R4759 T7380 T7379 punct ", ",provides
R4760 T7381 T7382 det the,mutant
R4761 T7382 T7379 nsubj mutant,provides
R4762 T7383 T7382 compound Trip13,mutant
R4763 T7384 T7385 det the,evidence
R4764 T7385 T7379 dobj evidence,provides
R4765 T7386 T7385 amod first,evidence
R4766 T7387 T7388 mark that,trigger
R4767 T7388 T7385 acl trigger,evidence
R4768 T7389 T7390 amod unrepaired,damage
R4769 T7390 T7388 nsubj damage,trigger
R4770 T7391 T7390 compound DNA,damage
R4771 T7392 T7390 advmod alone,damage
R4772 T7393 T7388 aux can,trigger
R4773 T7394 T7395 det the,response
R4774 T7395 T7388 dobj response,trigger
R4775 T7396 T7395 amod mammalian,response
R4776 T7397 T7398 compound pachytene,checkpoint
R4777 T7398 T7395 compound checkpoint,response
R4778 T7399 T7379 punct .,provides
R4779 T7401 T7402 advmod Furthermore,allow
R4780 T7403 T7402 punct ", ",allow
R4781 T7404 T7405 poss our,results
R4782 T7405 T7402 nsubj results,allow
R4783 T7406 T7407 nsubj us,conclude
R4784 T7407 T7402 ccomp conclude,allow
R4785 T7408 T7407 aux to,conclude
R4786 T7409 T7410 mark that,share
R4787 T7410 T7407 ccomp share,conclude
R4788 T7411 T7410 nsubj oocytes,share
R4789 T7412 T7411 cc and,oocytes
R4790 T7413 T7411 conj spermatocytes,oocytes
R4791 T7414 T7415 det a,checkpoint
R4792 T7415 T7410 dobj checkpoint,share
R4793 T7416 T7415 amod similar,checkpoint
R4794 T7417 T7416 punct ", ",similar
R4795 T7418 T7416 cc if,similar
R4796 T7419 T7418 neg not,if
R4797 T7420 T7416 conj identical,similar
R4798 T7421 T7415 punct ", ",checkpoint
R4799 T7422 T7423 compound DNA,damage
R4800 T7423 T7415 compound damage,checkpoint
R4801 T7424 T7415 compound pachytene,checkpoint
R4802 T7425 T7426 dep that,decoupled
R4803 T7426 T7415 relcl decoupled,checkpoint
R4804 T7427 T7426 auxpass is,decoupled
R4805 T7428 T7426 prep from,decoupled
R4806 T7429 T7430 det a,checkpoint
R4807 T7430 T7428 pobj checkpoint,from
R4808 T7431 T7430 compound synapsis,checkpoint
R4809 T7432 T7402 punct .,allow