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PMC:1941754 / 31471-32883 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T6704 0-3 PRP$ denotes Our
T6705 4-11 NNS denotes results
T6706 12-23 VBP denotes demonstrate
T6707 24-28 IN denotes that
T6709 29-31 IN denotes in
T6710 32-36 NNS denotes mice
T6711 36-38 , denotes ,
T6712 38-41 DT denotes the
T6714 42-49 JJ denotes primary
T6715 50-57 JJ denotes meiotic
T6713 58-66 NN denotes function
T6716 67-69 IN denotes of
T6717 70-76 NN denotes TRIP13
T6708 77-79 VBZ denotes is
T6718 80-82 IN denotes in
T6719 83-96 NN denotes recombination
T6720 97-103 PRP denotes itself
T6721 103-104 . denotes .
T6722 104-178 sentence denotes We found no evidence that it is involved in pachytene checkpoint control.
T6723 105-107 PRP denotes We
T6724 108-113 VBD denotes found
T6725 114-116 DT denotes no
T6726 117-125 NN denotes evidence
T6727 126-130 IN denotes that
T6729 131-133 PRP denotes it
T6730 134-136 VBZ denotes is
T6728 137-145 VBN denotes involved
T6731 146-148 IN denotes in
T6732 149-158 NN denotes pachytene
T6733 159-169 NN denotes checkpoint
T6734 170-177 NN denotes control
T6735 177-178 . denotes .
T6736 178-391 sentence denotes Our data suggest that while recombination events destined to be resolved as COs can proceed normally in Trip13 mutants, DSBs that enter the NCO repair pathway are incompletely resolved or processed inefficiently.
T6737 179-182 PRP$ denotes Our
T6738 183-187 NNS denotes data
T6739 188-195 VBP denotes suggest
T6740 196-200 IN denotes that
T6742 201-206 IN denotes while
T6744 207-220 NN denotes recombination
T6745 221-227 NNS denotes events
T6746 228-236 VBN denotes destined
T6747 237-239 TO denotes to
T6749 240-242 VB denotes be
T6748 243-251 VBN denotes resolved
T6750 252-254 IN denotes as
T6751 255-258 NNS denotes COs
T6752 259-262 MD denotes can
T6743 263-270 VB denotes proceed
T6753 271-279 RB denotes normally
T6754 280-282 IN denotes in
T6755 283-289 NN denotes Trip13
T6756 290-297 NNS denotes mutants
T6757 297-299 , denotes ,
T6758 299-303 NNS denotes DSBs
T6759 304-308 WDT denotes that
T6760 309-314 VBP denotes enter
T6761 315-318 DT denotes the
T6763 319-322 NN denotes NCO
T6764 323-329 NN denotes repair
T6762 330-337 NN denotes pathway
T6765 338-341 VBP denotes are
T6766 342-354 RB denotes incompletely
T6741 355-363 VBN denotes resolved
T6767 364-366 CC denotes or
T6768 367-376 VBN denotes processed
T6769 377-390 RB denotes inefficiently
T6770 390-391 . denotes .
T6771 391-479 sentence denotes This hypothesis is compatible with current knowledge of meiotic recombination pathways.
T6772 392-396 DT denotes This
T6773 397-407 NN denotes hypothesis
T6774 408-410 VBZ denotes is
T6775 411-421 JJ denotes compatible
T6776 422-426 IN denotes with
T6777 427-434 JJ denotes current
T6778 435-444 NN denotes knowledge
T6779 445-447 IN denotes of
T6780 448-455 JJ denotes meiotic
T6781 456-469 NN denotes recombination
T6782 470-478 NNS denotes pathways
T6783 478-479 . denotes .
T6784 479-636 sentence denotes In S. cerevisiae, CO and NCO pathways are distinct [43]; they have different recombination intermediates, and are dependent upon different proteins [44,45].
T6785 480-482 IN denotes In
T6787 483-485 NNP denotes S.
T6788 486-496 NNP denotes cerevisiae
T6789 496-498 , denotes ,
T6790 498-500 NN denotes CO
T6792 501-504 CC denotes and
T6793 505-508 NN denotes NCO
T6791 509-517 NNS denotes pathways
T6786 518-521 VBP denotes are
T6795 522-530 JJ denotes distinct
T6796 531-532 -LRB- denotes [
T6797 532-534 CD denotes 43
T6798 534-535 -RRB- denotes ]
T6799 535-536 : denotes ;
T6800 537-541 PRP denotes they
T6794 542-546 VBP denotes have
T6801 547-556 JJ denotes different
T6803 557-570 NN denotes recombination
T6802 571-584 NNS denotes intermediates
T6804 584-586 , denotes ,
T6805 586-589 CC denotes and
T6806 590-593 VBP denotes are
T6807 594-603 JJ denotes dependent
T6808 604-608 IN denotes upon
T6809 609-618 JJ denotes different
T6810 619-627 NN denotes proteins
T6811 628-629 -LRB- denotes [
T6813 629-631 CD denotes 44
T6814 631-632 , denotes ,
T6812 632-634 CD denotes 45
T6815 634-635 -RRB- denotes ]
T6816 635-636 . denotes .
T6817 636-716 sentence denotes Mice also appear to have independent CO versus NCO recombination pathways [46].
T6818 637-641 NNS denotes Mice
T6820 642-646 RB denotes also
T6819 647-653 VBP denotes appear
T6821 654-656 TO denotes to
T6822 657-661 VB denotes have
T6823 662-673 JJ denotes independent
T6825 674-676 NN denotes CO
T6826 677-683 CC denotes versus
T6827 684-687 NN denotes NCO
T6828 688-701 NN denotes recombination
T6824 702-710 NNS denotes pathways
T6829 711-712 -LRB- denotes [
T6830 712-714 CD denotes 46
T6831 714-715 -RRB- denotes ]
T6832 715-716 . denotes .
T6833 716-803 sentence denotes As in yeast, both require SPO11-induced breaks, but only the CO pathway requires MLH1.
T6834 717-719 IN denotes As
T6836 720-722 IN denotes in
T6837 723-728 NN denotes yeast
T6838 728-730 , denotes ,
T6839 730-734 DT denotes both
T6835 735-742 VBP denotes require
T6840 743-748 NN denotes SPO11
T6842 748-749 HYPH denotes -
T6841 749-756 VBN denotes induced
T6843 757-763 NNS denotes breaks
T6844 763-765 , denotes ,
T6845 765-768 CC denotes but
T6846 769-773 RB denotes only
T6848 774-777 DT denotes the
T6849 778-780 NN denotes CO
T6847 781-788 NN denotes pathway
T6850 789-797 VBZ denotes requires
T6851 798-802 NN denotes MLH1
T6852 802-803 . denotes .
T6853 803-872 sentence denotes Both types of recombinant products are formed by mid-late pachynema.
T6854 804-808 DT denotes Both
T6855 809-814 NNS denotes types
T6857 815-817 IN denotes of
T6858 818-829 JJ denotes recombinant
T6859 830-838 NNS denotes products
T6860 839-842 VBP denotes are
T6856 843-849 VBN denotes formed
T6861 850-852 IN denotes by
T6862 853-856 JJ denotes mid
T6864 856-857 SYM denotes -
T6863 857-861 JJ denotes late
T6865 862-871 NN denotes pachynema
T6866 871-872 . denotes .
T6867 872-979 sentence denotes Another possibility is that the recombination defects are a result of defective intersister recombination.
T6868 873-880 DT denotes Another
T6869 881-892 NN denotes possibility
T6870 893-895 VBZ denotes is
T6871 896-900 IN denotes that
T6873 901-904 DT denotes the
T6875 905-918 NN denotes recombination
T6874 919-926 NNS denotes defects
T6872 927-930 VBP denotes are
T6876 931-932 DT denotes a
T6877 933-939 NN denotes result
T6878 940-942 IN denotes of
T6879 943-952 JJ denotes defective
T6881 953-964 JJ denotes intersister
T6880 965-978 NN denotes recombination
T6882 978-979 . denotes .
T6883 979-1044 sentence denotes However, this type of DSB repair is suppressed in meiotic cells.
T6884 980-987 RB denotes However
T6886 987-989 , denotes ,
T6887 989-993 DT denotes this
T6888 994-998 NN denotes type
T6889 999-1001 IN denotes of
T6890 1002-1005 NN denotes DSB
T6891 1006-1012 NN denotes repair
T6892 1013-1015 VBZ denotes is
T6885 1016-1026 VBN denotes suppressed
T6893 1027-1029 IN denotes in
T6894 1030-1037 JJ denotes meiotic
T6895 1038-1043 NNS denotes cells
T6896 1043-1044 . denotes .
T6897 1044-1186 sentence denotes Ablation of RAD54, which mediates intersister recombination in yeast, does not significantly disrupt meiosis in either yeast or mice [47,48].
T6898 1045-1053 NN denotes Ablation
T6900 1054-1056 IN denotes of
T6901 1057-1062 NN denotes RAD54
T6902 1062-1064 , denotes ,
T6903 1064-1069 WDT denotes which
T6904 1070-1078 VBZ denotes mediates
T6905 1079-1090 JJ denotes intersister
T6906 1091-1104 NN denotes recombination
T6907 1105-1107 IN denotes in
T6908 1108-1113 NN denotes yeast
T6909 1113-1115 , denotes ,
T6910 1115-1119 VBZ denotes does
T6911 1120-1123 RB denotes not
T6912 1124-1137 RB denotes significantly
T6899 1138-1145 VB denotes disrupt
T6913 1146-1153 NN denotes meiosis
T6914 1154-1156 IN denotes in
T6915 1157-1163 CC denotes either
T6916 1164-1169 NN denotes yeast
T6917 1170-1172 CC denotes or
T6918 1173-1177 NNS denotes mice
T6919 1178-1179 -LRB- denotes [
T6921 1179-1181 CD denotes 47
T6922 1181-1182 , denotes ,
T6920 1182-1184 CD denotes 48
T6923 1184-1185 -RRB- denotes ]
T6924 1185-1186 . denotes .
T6925 1186-1412 sentence denotes Interestingly, RAD54-deficient spermatocytes display abnormal persistence of RAD51 foci on pachytene chromosomes, similar to those in TRIP13 mice, but there are no deleterious effects on meiotic progression or fertility [49].
T6926 1187-1200 RB denotes Interestingly
T6928 1200-1202 , denotes ,
T6929 1202-1207 NN denotes RAD54
T6931 1207-1208 HYPH denotes -
T6930 1208-1217 JJ denotes deficient
T6932 1218-1231 NNS denotes spermatocytes
T6927 1232-1239 VBP denotes display
T6933 1240-1248 JJ denotes abnormal
T6934 1249-1260 NN denotes persistence
T6935 1261-1263 IN denotes of
T6936 1264-1269 NN denotes RAD51
T6937 1270-1274 NNS denotes foci
T6938 1275-1277 IN denotes on
T6939 1278-1287 NN denotes pachytene
T6940 1288-1299 NNS denotes chromosomes
T6941 1299-1301 , denotes ,
T6942 1301-1308 JJ denotes similar
T6943 1309-1311 IN denotes to
T6944 1312-1317 DT denotes those
T6945 1318-1320 IN denotes in
T6946 1321-1327 NN denotes TRIP13
T6947 1328-1332 NNS denotes mice
T6948 1332-1334 , denotes ,
T6949 1334-1337 CC denotes but
T6950 1338-1343 EX denotes there
T6951 1344-1347 VBP denotes are
T6952 1348-1350 DT denotes no
T6954 1351-1362 JJ denotes deleterious
T6953 1363-1370 NNS denotes effects
T6955 1371-1373 IN denotes on
T6956 1374-1381 JJ denotes meiotic
T6957 1382-1393 NN denotes progression
T6958 1394-1396 CC denotes or
T6959 1397-1406 NN denotes fertility
T6960 1407-1408 -LRB- denotes [
T6961 1408-1410 CD denotes 49
T6962 1410-1411 -RRB- denotes ]
T6963 1411-1412 . denotes .
R4136 T6704 T6705 poss Our,results
R4137 T6705 T6706 nsubj results,demonstrate
R4138 T6707 T6708 mark that,is
R4139 T6708 T6706 ccomp is,demonstrate
R4140 T6709 T6708 prep in,is
R4141 T6710 T6709 pobj mice,in
R4142 T6711 T6708 punct ", ",is
R4143 T6712 T6713 det the,function
R4144 T6713 T6708 nsubj function,is
R4145 T6714 T6713 amod primary,function
R4146 T6715 T6713 amod meiotic,function
R4147 T6716 T6713 prep of,function
R4148 T6717 T6716 pobj TRIP13,of
R4149 T6718 T6708 prep in,is
R4150 T6719 T6718 pobj recombination,in
R4151 T6720 T6719 appos itself,recombination
R4152 T6721 T6706 punct .,demonstrate
R4153 T6723 T6724 nsubj We,found
R4154 T6725 T6726 det no,evidence
R4155 T6726 T6724 dobj evidence,found
R4156 T6727 T6728 mark that,involved
R4157 T6728 T6726 acl involved,evidence
R4158 T6729 T6728 nsubjpass it,involved
R4159 T6730 T6728 auxpass is,involved
R4160 T6731 T6728 prep in,involved
R4161 T6732 T6733 compound pachytene,checkpoint
R4162 T6733 T6734 compound checkpoint,control
R4163 T6734 T6731 pobj control,in
R4164 T6735 T6724 punct .,found
R4165 T6737 T6738 poss Our,data
R4166 T6738 T6739 nsubj data,suggest
R4167 T6740 T6741 mark that,resolved
R4168 T6741 T6739 ccomp resolved,suggest
R4169 T6742 T6743 mark while,proceed
R4170 T6743 T6741 advcl proceed,resolved
R4171 T6744 T6745 compound recombination,events
R4172 T6745 T6743 nsubj events,proceed
R4173 T6746 T6745 acl destined,events
R4174 T6747 T6748 aux to,resolved
R4175 T6748 T6746 xcomp resolved,destined
R4176 T6749 T6748 auxpass be,resolved
R4177 T6750 T6748 prep as,resolved
R4178 T6751 T6750 pobj COs,as
R4179 T6752 T6743 aux can,proceed
R4180 T6753 T6743 advmod normally,proceed
R4181 T6754 T6743 prep in,proceed
R4182 T6755 T6756 compound Trip13,mutants
R4183 T6756 T6754 pobj mutants,in
R4184 T6757 T6741 punct ", ",resolved
R4185 T6758 T6741 nsubjpass DSBs,resolved
R4186 T6759 T6760 dep that,enter
R4187 T6760 T6758 relcl enter,DSBs
R4188 T6761 T6762 det the,pathway
R4189 T6762 T6760 dobj pathway,enter
R4190 T6763 T6762 compound NCO,pathway
R4191 T6764 T6762 compound repair,pathway
R4192 T6765 T6741 auxpass are,resolved
R4193 T6766 T6741 advmod incompletely,resolved
R4194 T6767 T6741 cc or,resolved
R4195 T6768 T6741 conj processed,resolved
R4196 T6769 T6768 advmod inefficiently,processed
R4197 T6770 T6739 punct .,suggest
R4198 T6772 T6773 det This,hypothesis
R4199 T6773 T6774 nsubj hypothesis,is
R4200 T6775 T6774 acomp compatible,is
R4201 T6776 T6775 prep with,compatible
R4202 T6777 T6778 amod current,knowledge
R4203 T6778 T6776 pobj knowledge,with
R4204 T6779 T6778 prep of,knowledge
R4205 T6780 T6781 amod meiotic,recombination
R4206 T6781 T6782 compound recombination,pathways
R4207 T6782 T6779 pobj pathways,of
R4208 T6783 T6774 punct .,is
R4209 T6785 T6786 prep In,are
R4210 T6786 T6794 ccomp are,have
R4211 T6787 T6788 compound S.,cerevisiae
R4212 T6788 T6785 pobj cerevisiae,In
R4213 T6789 T6786 punct ", ",are
R4214 T6790 T6791 nmod CO,pathways
R4215 T6791 T6786 nsubj pathways,are
R4216 T6792 T6790 cc and,CO
R4217 T6793 T6790 conj NCO,CO
R4218 T6795 T6786 acomp distinct,are
R4219 T6796 T6797 punct [,43
R4220 T6797 T6786 parataxis 43,are
R4221 T6798 T6797 punct ],43
R4222 T6799 T6794 punct ;,have
R4223 T6800 T6794 nsubj they,have
R4224 T6801 T6802 amod different,intermediates
R4225 T6802 T6794 dobj intermediates,have
R4226 T6803 T6802 compound recombination,intermediates
R4227 T6804 T6794 punct ", ",have
R4228 T6805 T6794 cc and,have
R4229 T6806 T6794 conj are,have
R4230 T6807 T6806 acomp dependent,are
R4231 T6808 T6807 prep upon,dependent
R4232 T6809 T6810 amod different,proteins
R4233 T6810 T6808 pobj proteins,upon
R4234 T6811 T6812 punct [,45
R4235 T6812 T6806 parataxis 45,are
R4236 T6813 T6812 nummod 44,45
R4237 T6814 T6812 punct ",",45
R4238 T6815 T6812 punct ],45
R4239 T6816 T6794 punct .,have
R4240 T6818 T6819 nsubj Mice,appear
R4241 T6820 T6819 advmod also,appear
R4242 T6821 T6822 aux to,have
R4243 T6822 T6819 xcomp have,appear
R4244 T6823 T6824 amod independent,pathways
R4245 T6824 T6822 dobj pathways,have
R4246 T6825 T6824 nmod CO,pathways
R4247 T6826 T6825 cc versus,CO
R4248 T6827 T6825 conj NCO,CO
R4249 T6828 T6824 compound recombination,pathways
R4250 T6829 T6830 punct [,46
R4251 T6830 T6819 parataxis 46,appear
R4252 T6831 T6830 punct ],46
R4253 T6832 T6819 punct .,appear
R4254 T6834 T6835 prep As,require
R4255 T6836 T6834 prep in,As
R4256 T6837 T6836 pobj yeast,in
R4257 T6838 T6835 punct ", ",require
R4258 T6839 T6835 nsubj both,require
R4259 T6840 T6841 npadvmod SPO11,induced
R4260 T6841 T6843 amod induced,breaks
R4261 T6842 T6841 punct -,induced
R4262 T6843 T6835 dobj breaks,require
R4263 T6844 T6835 punct ", ",require
R4264 T6845 T6835 cc but,require
R4265 T6846 T6847 advmod only,pathway
R4266 T6847 T6850 nsubj pathway,requires
R4267 T6848 T6847 det the,pathway
R4268 T6849 T6847 compound CO,pathway
R4269 T6850 T6835 conj requires,require
R4270 T6851 T6850 dobj MLH1,requires
R4271 T6852 T6850 punct .,requires
R4272 T6854 T6855 det Both,types
R4273 T6855 T6856 nsubjpass types,formed
R4274 T6857 T6855 prep of,types
R4275 T6858 T6859 amod recombinant,products
R4276 T6859 T6857 pobj products,of
R4277 T6860 T6856 auxpass are,formed
R4278 T6861 T6856 prep by,formed
R4279 T6862 T6863 amod mid,late
R4280 T6863 T6865 amod late,pachynema
R4281 T6864 T6863 punct -,late
R4282 T6865 T6861 pobj pachynema,by
R4283 T6866 T6856 punct .,formed
R4284 T6868 T6869 det Another,possibility
R4285 T6869 T6870 nsubj possibility,is
R4286 T6871 T6872 mark that,are
R4287 T6872 T6870 ccomp are,is
R4288 T6873 T6874 det the,defects
R4289 T6874 T6872 nsubj defects,are
R4290 T6875 T6874 compound recombination,defects
R4291 T6876 T6877 det a,result
R4292 T6877 T6872 attr result,are
R4293 T6878 T6877 prep of,result
R4294 T6879 T6880 amod defective,recombination
R4295 T6880 T6878 pobj recombination,of
R4296 T6881 T6880 amod intersister,recombination
R4297 T6882 T6870 punct .,is
R4298 T6884 T6885 advmod However,suppressed
R4299 T6886 T6885 punct ", ",suppressed
R4300 T6887 T6888 det this,type
R4301 T6888 T6885 nsubjpass type,suppressed
R4302 T6889 T6888 prep of,type
R4303 T6890 T6891 compound DSB,repair
R4304 T6891 T6889 pobj repair,of
R4305 T6892 T6885 auxpass is,suppressed
R4306 T6893 T6885 prep in,suppressed
R4307 T6894 T6895 amod meiotic,cells
R4308 T6895 T6893 pobj cells,in
R4309 T6896 T6885 punct .,suppressed
R4310 T6898 T6899 nsubj Ablation,disrupt
R4311 T6900 T6898 prep of,Ablation
R4312 T6901 T6900 pobj RAD54,of
R4313 T6902 T6901 punct ", ",RAD54
R4314 T6903 T6904 dep which,mediates
R4315 T6904 T6901 relcl mediates,RAD54
R4316 T6905 T6906 amod intersister,recombination
R4317 T6906 T6904 dobj recombination,mediates
R4318 T6907 T6906 prep in,recombination
R4319 T6908 T6907 pobj yeast,in
R4320 T6909 T6899 punct ", ",disrupt
R4321 T6910 T6899 aux does,disrupt
R4322 T6911 T6899 neg not,disrupt
R4323 T6912 T6899 advmod significantly,disrupt
R4324 T6913 T6899 dobj meiosis,disrupt
R4325 T6914 T6899 prep in,disrupt
R4326 T6915 T6916 preconj either,yeast
R4327 T6916 T6914 pobj yeast,in
R4328 T6917 T6916 cc or,yeast
R4329 T6918 T6916 conj mice,yeast
R4330 T6919 T6920 punct [,48
R4331 T6920 T6899 parataxis 48,disrupt
R4332 T6921 T6920 nummod 47,48
R4333 T6922 T6920 punct ",",48
R4334 T6923 T6920 punct ],48
R4335 T6924 T6899 punct .,disrupt
R4336 T6926 T6927 advmod Interestingly,display
R4337 T6928 T6927 punct ", ",display
R4338 T6929 T6930 npadvmod RAD54,deficient
R4339 T6930 T6932 amod deficient,spermatocytes
R4340 T6931 T6930 punct -,deficient
R4341 T6932 T6927 nsubj spermatocytes,display
R4342 T6933 T6934 amod abnormal,persistence
R4343 T6934 T6927 dobj persistence,display
R4344 T6935 T6934 prep of,persistence
R4345 T6936 T6937 compound RAD51,foci
R4346 T6937 T6935 pobj foci,of
R4347 T6938 T6927 prep on,display
R4348 T6939 T6940 compound pachytene,chromosomes
R4349 T6940 T6938 pobj chromosomes,on
R4350 T6941 T6940 punct ", ",chromosomes
R4351 T6942 T6940 amod similar,chromosomes
R4352 T6943 T6942 prep to,similar
R4353 T6944 T6943 pobj those,to
R4354 T6945 T6944 prep in,those
R4355 T6946 T6947 compound TRIP13,mice
R4356 T6947 T6945 pobj mice,in
R4357 T6948 T6927 punct ", ",display
R4358 T6949 T6927 cc but,display
R4359 T6950 T6951 expl there,are
R4360 T6951 T6927 conj are,display
R4361 T6952 T6953 det no,effects
R4362 T6953 T6951 attr effects,are
R4363 T6954 T6953 amod deleterious,effects
R4364 T6955 T6953 prep on,effects
R4365 T6956 T6957 amod meiotic,progression
R4366 T6957 T6955 pobj progression,on
R4367 T6958 T6957 cc or,progression
R4368 T6959 T6957 conj fertility,progression
R4369 T6960 T6961 punct [,49
R4370 T6961 T6951 parataxis 49,are
R4371 T6962 T6961 punct ],49
R4372 T6963 T6951 punct .,are