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PMC:1941754 / 2960-6543 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T668 13-16 DT denotes The
T669 17-24 NN denotes genesis
T671 25-27 IN denotes of
T672 28-35 NNS denotes gametes
T673 36-46 VBG denotes containing
T674 47-49 DT denotes an
T676 50-56 JJ denotes intact
T677 56-58 , denotes ,
T678 58-65 JJ denotes haploid
T675 66-72 NN denotes genome
T670 73-75 VBZ denotes is
T679 76-84 JJ denotes critical
T680 85-88 IN denotes for
T681 89-92 DT denotes the
T682 93-103 NN denotes prevention
T683 104-106 IN denotes of
T684 107-112 NN denotes birth
T685 113-120 NNS denotes defects
T686 120-122 , denotes ,
T687 122-125 CC denotes and
T688 126-128 VBZ denotes is
T689 129-135 RB denotes highly
T690 136-145 JJ denotes dependent
T691 146-150 IN denotes upon
T692 151-154 DT denotes the
T693 155-163 NN denotes fidelity
T694 164-166 IN denotes of
T695 167-177 NN denotes chromosome
T696 178-186 NNS denotes dynamics
T697 187-193 IN denotes before
T698 194-197 DT denotes the
T700 198-203 JJ denotes first
T701 204-211 JJ denotes meiotic
T699 212-220 NN denotes division
T702 220-221 . denotes .
T703 221-329 sentence denotes Homologous chromosomes must pair, synapse, undergo recombination, and segregate properly to opposite poles.
T704 222-232 JJ denotes Homologous
T705 233-244 NNS denotes chromosomes
T707 245-249 MD denotes must
T706 250-254 VB denotes pair
T708 254-256 , denotes ,
T709 256-263 VB denotes synapse
T710 263-265 , denotes ,
T711 265-272 VB denotes undergo
T712 273-286 NN denotes recombination
T713 286-288 , denotes ,
T714 288-291 CC denotes and
T715 292-301 VB denotes segregate
T716 302-310 RB denotes properly
T717 311-313 IN denotes to
T718 314-322 JJ denotes opposite
T719 323-328 NNS denotes poles
T720 328-329 . denotes .
T721 329-491 sentence denotes Recombination, which repairs repair double strand breaks (DSBs) that are genetically induced in leptonema, is coupled with synapsis in budding yeast and mammals.
T722 330-343 NN denotes Recombination
T724 343-345 , denotes ,
T725 345-350 WDT denotes which
T726 351-358 VBZ denotes repairs
T727 359-365 NN denotes repair
T729 366-372 JJ denotes double
T730 373-379 NN denotes strand
T728 380-386 NNS denotes breaks
T731 387-388 -LRB- denotes (
T732 388-392 NNS denotes DSBs
T733 392-393 -RRB- denotes )
T734 394-398 WDT denotes that
T736 399-402 VBP denotes are
T737 403-414 RB denotes genetically
T735 415-422 VBN denotes induced
T738 423-425 IN denotes in
T739 426-435 NN denotes leptonema
T740 435-437 , denotes ,
T741 437-439 VBZ denotes is
T723 440-447 VBN denotes coupled
T742 448-452 IN denotes with
T743 453-461 NN denotes synapsis
T744 462-464 IN denotes in
T745 465-472 VBG denotes budding
T746 473-478 NN denotes yeast
T747 479-482 CC denotes and
T748 483-490 NNS denotes mammals
T749 490-491 . denotes .
T750 491-783 sentence denotes While our knowledge of the assembly and nature of recombination machinery is extensive, little is known about the disassembly of recombination intermediates, recruitment of DNA replication machinery during recombinational repair, and how the choice between different repair pathways is made.
T751 492-497 IN denotes While
T753 498-501 PRP$ denotes our
T754 502-511 NN denotes knowledge
T755 512-514 IN denotes of
T756 515-518 DT denotes the
T757 519-527 NN denotes assembly
T758 528-531 CC denotes and
T759 532-538 NN denotes nature
T760 539-541 IN denotes of
T761 542-555 NN denotes recombination
T762 556-565 NN denotes machinery
T752 566-568 VBZ denotes is
T764 569-578 JJ denotes extensive
T765 578-580 , denotes ,
T766 580-586 JJ denotes little
T767 587-589 VBZ denotes is
T763 590-595 VBN denotes known
T768 596-601 IN denotes about
T769 602-605 DT denotes the
T770 606-617 NN denotes disassembly
T771 618-620 IN denotes of
T772 621-634 NN denotes recombination
T773 635-648 NNS denotes intermediates
T774 648-650 , denotes ,
T775 650-661 NN denotes recruitment
T776 662-664 IN denotes of
T777 665-668 NN denotes DNA
T779 669-680 NN denotes replication
T778 681-690 NN denotes machinery
T780 691-697 IN denotes during
T781 698-713 JJ denotes recombinational
T782 714-720 NN denotes repair
T783 720-722 , denotes ,
T784 722-725 CC denotes and
T785 726-729 WRB denotes how
T787 730-733 DT denotes the
T788 734-740 NN denotes choice
T789 741-748 IN denotes between
T790 749-758 JJ denotes different
T792 759-765 NN denotes repair
T791 766-774 NNS denotes pathways
T793 775-777 VBZ denotes is
T786 778-782 VBN denotes made
T794 782-783 . denotes .
T795 783-938 sentence denotes Defects in recombination can preclude homologous chromosome pairing, leave unrepaired chromosome breaks, and cause aneuploidy by abrogating crossing over.
T796 784-791 NNS denotes Defects
T798 792-794 IN denotes in
T799 795-808 NN denotes recombination
T800 809-812 MD denotes can
T797 813-821 VB denotes preclude
T801 822-832 JJ denotes homologous
T803 833-843 NN denotes chromosome
T802 844-851 NN denotes pairing
T804 851-853 , denotes ,
T805 853-858 VBP denotes leave
T806 859-869 JJ denotes unrepaired
T808 870-880 NN denotes chromosome
T807 881-887 NNS denotes breaks
T809 887-889 , denotes ,
T810 889-892 CC denotes and
T811 893-898 VBP denotes cause
T812 899-909 NN denotes aneuploidy
T813 910-912 IN denotes by
T814 913-923 VBG denotes abrogating
T815 924-932 VBG denotes crossing
T816 933-937 RP denotes over
T817 937-938 . denotes .
T818 938-1092 sentence denotes To avoid such deleterious outcomes, surveillance systems (“checkpoints”) exist to sense meiotic errors and eliminate cells containing unresolved defects.
T819 939-941 TO denotes To
T820 942-947 VB denotes avoid
T822 948-952 JJ denotes such
T824 953-964 JJ denotes deleterious
T823 965-973 NNS denotes outcomes
T825 973-975 , denotes ,
T826 975-987 NN denotes surveillance
T827 988-995 NNS denotes systems
T828 996-997 -LRB- denotes (
T829 997-998 `` denotes “
T830 998-1009 NNS denotes checkpoints
T831 1009-1010 '' denotes ”
T832 1010-1011 -RRB- denotes )
T821 1012-1017 VBP denotes exist
T833 1018-1020 TO denotes to
T834 1021-1026 VB denotes sense
T835 1027-1034 JJ denotes meiotic
T836 1035-1041 NNS denotes errors
T837 1042-1045 CC denotes and
T838 1046-1055 VB denotes eliminate
T839 1056-1061 NNS denotes cells
T840 1062-1072 VBG denotes containing
T841 1073-1083 JJ denotes unresolved
T842 1084-1091 NNS denotes defects
T843 1091-1092 . denotes .
T844 1092-1325 sentence denotes In many organisms, including S. cerevisiae, Drosophila melanogaster, C. elegans, and mice [1–4], meiocytes with defects in recombination and/or chromosome synapsis trigger meiotic arrest in the pachytene stage of meiotic prophase I.
T845 1093-1095 IN denotes In
T847 1096-1100 JJ denotes many
T848 1101-1110 NNS denotes organisms
T849 1110-1112 , denotes ,
T850 1112-1121 VBG denotes including
T851 1122-1124 NNP denotes S.
T852 1125-1135 NNP denotes cerevisiae
T853 1135-1137 , denotes ,
T854 1137-1147 NNP denotes Drosophila
T855 1148-1160 NNP denotes melanogaster
T856 1160-1162 , denotes ,
T857 1162-1164 NNP denotes C.
T858 1165-1172 NNP denotes elegans
T859 1172-1174 , denotes ,
T860 1174-1177 CC denotes and
T861 1178-1182 NNS denotes mice
T862 1183-1184 -LRB- denotes [
T863 1184-1185 CD denotes 1
T864 1185-1186 SYM denotes –
T865 1186-1187 CD denotes 4
T866 1187-1188 -RRB- denotes ]
T867 1188-1190 , denotes ,
T868 1190-1199 NNS denotes meiocytes
T869 1200-1204 IN denotes with
T870 1205-1212 NNS denotes defects
T871 1213-1215 IN denotes in
T872 1216-1229 NN denotes recombination
T873 1230-1233 CC denotes and
T874 1233-1234 HYPH denotes /
T875 1234-1236 CC denotes or
T876 1237-1247 NN denotes chromosome
T877 1248-1256 NN denotes synapsis
T846 1257-1264 VBP denotes trigger
T878 1265-1272 JJ denotes meiotic
T879 1273-1279 NN denotes arrest
T880 1280-1282 IN denotes in
T881 1283-1286 DT denotes the
T883 1287-1296 NN denotes pachytene
T882 1297-1302 NN denotes stage
T884 1303-1305 IN denotes of
T885 1306-1313 JJ denotes meiotic
T886 1314-1322 NN denotes prophase
T887 1323-1324 CD denotes I
T888 1324-1325 . denotes .
T889 1325-1422 sentence denotes This response to meiotic defects is referred to as the “pachytene checkpoint” (reviewed in [5]).
T890 1326-1330 DT denotes This
T891 1331-1339 NN denotes response
T893 1340-1342 IN denotes to
T894 1343-1350 JJ denotes meiotic
T895 1351-1358 NNS denotes defects
T896 1359-1361 VBZ denotes is
T892 1362-1370 VBN denotes referred
T897 1371-1373 IN denotes to
T898 1374-1376 IN denotes as
T899 1377-1380 DT denotes the
T901 1381-1382 `` denotes “
T902 1382-1391 NN denotes pachytene
T900 1392-1402 NN denotes checkpoint
T903 1402-1403 NN denotes ”
T904 1404-1405 -LRB- denotes (
T905 1405-1413 VBN denotes reviewed
T906 1414-1416 IN denotes in
T907 1417-1418 -LRB- denotes [
T908 1418-1419 CD denotes 5
T909 1419-1420 -RRB- denotes ]
T910 1420-1421 -RRB- denotes )
T911 1421-1422 . denotes .
T912 1422-1541 sentence denotes Genetic experiments in S. cerevisiae have identified elements of the pachytene checkpoint machinery (reviewed in [5]).
T913 1423-1430 JJ denotes Genetic
T914 1431-1442 NNS denotes experiments
T916 1443-1445 IN denotes in
T917 1446-1448 NNP denotes S.
T918 1449-1459 NNP denotes cerevisiae
T919 1460-1464 VBP denotes have
T915 1465-1475 VBN denotes identified
T920 1476-1484 NNS denotes elements
T921 1485-1487 IN denotes of
T922 1488-1491 DT denotes the
T924 1492-1501 NN denotes pachytene
T925 1502-1512 NN denotes checkpoint
T923 1513-1522 NN denotes machinery
T926 1523-1524 -LRB- denotes (
T927 1524-1532 VBN denotes reviewed
T928 1533-1535 IN denotes in
T929 1536-1537 -LRB- denotes [
T930 1537-1538 CD denotes 5
T931 1538-1539 -RRB- denotes ]
T932 1539-1540 -RRB- denotes )
T933 1540-1541 . denotes .
T934 1541-1670 sentence denotes In addition to meiosis-specific proteins, these include factors that play roles in DNA damage signaling in mitotic cells [6–10].
T935 1542-1544 IN denotes In
T937 1545-1553 NN denotes addition
T938 1554-1556 IN denotes to
T939 1557-1564 NN denotes meiosis
T941 1564-1565 HYPH denotes -
T940 1565-1573 JJ denotes specific
T942 1574-1582 NN denotes proteins
T943 1582-1584 , denotes ,
T944 1584-1589 DT denotes these
T936 1590-1597 VBP denotes include
T945 1598-1605 NNS denotes factors
T946 1606-1610 WDT denotes that
T947 1611-1615 VBP denotes play
T948 1616-1621 NNS denotes roles
T949 1622-1624 IN denotes in
T950 1625-1628 NN denotes DNA
T951 1629-1635 NN denotes damage
T952 1636-1645 NN denotes signaling
T953 1646-1648 IN denotes in
T954 1649-1656 JJ denotes mitotic
T955 1657-1662 NNS denotes cells
T956 1663-1664 -LRB- denotes [
T957 1664-1665 CD denotes 6
T958 1665-1666 SYM denotes –
T959 1666-1668 CD denotes 10
T960 1668-1669 -RRB- denotes ]
T961 1669-1670 . denotes .
T962 1670-1790 sentence denotes Arabidopsis thaliana does not appear to have a pachytene checkpoint akin to that in yeast [11], nor do male Drosophila.
T963 1671-1682 NNP denotes Arabidopsis
T964 1683-1691 NNP denotes thaliana
T966 1692-1696 VBZ denotes does
T967 1697-1700 RB denotes not
T965 1701-1707 VB denotes appear
T968 1708-1710 TO denotes to
T969 1711-1715 VB denotes have
T970 1716-1717 DT denotes a
T972 1718-1727 NN denotes pachytene
T971 1728-1738 NN denotes checkpoint
T973 1739-1743 JJ denotes akin
T974 1744-1746 IN denotes to
T975 1747-1751 DT denotes that
T976 1752-1754 IN denotes in
T977 1755-1760 NN denotes yeast
T978 1761-1762 -LRB- denotes [
T979 1762-1764 CD denotes 11
T980 1764-1765 -RRB- denotes ]
T981 1765-1767 , denotes ,
T982 1767-1770 CC denotes nor
T983 1771-1773 VB denotes do
T984 1774-1778 JJ denotes male
T985 1779-1789 NNP denotes Drosophila
T986 1789-1790 . denotes .
T987 1790-1964 sentence denotes The pachytene checkpoint is known to monitor two aspects of meiotic chromosome metabolism in S. cerevisiae and C. elegans: (1) DSB repair and (2) chromosome synapsis [2,12].
T988 1791-1794 DT denotes The
T990 1795-1804 NN denotes pachytene
T989 1805-1815 NN denotes checkpoint
T992 1816-1818 VBZ denotes is
T991 1819-1824 VBN denotes known
T993 1825-1827 TO denotes to
T994 1828-1835 VB denotes monitor
T995 1836-1839 CD denotes two
T996 1840-1847 NNS denotes aspects
T997 1848-1850 IN denotes of
T998 1851-1858 JJ denotes meiotic
T1000 1859-1869 NN denotes chromosome
T999 1870-1880 NN denotes metabolism
T1001 1881-1883 IN denotes in
T1002 1884-1886 NNP denotes S.
T1003 1887-1897 NNP denotes cerevisiae
T1004 1898-1901 CC denotes and
T1005 1902-1904 NNP denotes C.
T1006 1905-1912 NNP denotes elegans
T1007 1912-1914 : denotes :
T1008 1914-1915 -LRB- denotes (
T1009 1915-1916 LS denotes 1
T1011 1916-1917 -RRB- denotes )
T1012 1918-1921 NN denotes DSB
T1010 1922-1928 NN denotes repair
T1013 1929-1932 CC denotes and
T1014 1933-1934 -LRB- denotes (
T1015 1934-1935 LS denotes 2
T1017 1935-1936 -RRB- denotes )
T1018 1937-1947 NN denotes chromosome
T1016 1948-1956 NN denotes synapsis
T1019 1957-1958 -LRB- denotes [
T1021 1958-1959 CD denotes 2
T1022 1959-1960 , denotes ,
T1020 1960-1962 CD denotes 12
T1023 1962-1963 -RRB- denotes ]
T1024 1963-1964 . denotes .
T1025 1964-2226 sentence denotes In mice, both spermatocytes and oocytes harboring mutations that disrupt DSB repair (such as Dmc1, Msh5, and Atm) are efficiently eliminated in pachynema, but spermatocytes are much more sensitive to DSB repair–independent synapsis defects than oocytes [13–15].
T1026 1965-1967 IN denotes In
T1028 1968-1972 NNS denotes mice
T1029 1972-1974 , denotes ,
T1030 1974-1978 CC denotes both
T1031 1979-1992 NNS denotes spermatocytes
T1032 1993-1996 CC denotes and
T1033 1997-2004 NNS denotes oocytes
T1034 2005-2014 VBG denotes harboring
T1035 2015-2024 NNS denotes mutations
T1036 2025-2029 WDT denotes that
T1037 2030-2037 VBP denotes disrupt
T1038 2038-2041 NN denotes DSB
T1039 2042-2048 NN denotes repair
T1040 2049-2050 -LRB- denotes (
T1041 2050-2054 JJ denotes such
T1042 2055-2057 IN denotes as
T1043 2058-2062 NN denotes Dmc1
T1044 2062-2064 , denotes ,
T1045 2064-2068 NN denotes Msh5
T1046 2068-2070 , denotes ,
T1047 2070-2073 CC denotes and
T1048 2074-2077 NN denotes Atm
T1049 2077-2078 -RRB- denotes )
T1050 2079-2082 VBP denotes are
T1051 2083-2094 RB denotes efficiently
T1027 2095-2105 VBN denotes eliminated
T1052 2106-2108 IN denotes in
T1053 2109-2118 NN denotes pachynema
T1054 2118-2120 , denotes ,
T1055 2120-2123 CC denotes but
T1056 2124-2137 NNS denotes spermatocytes
T1057 2138-2141 VBP denotes are
T1058 2142-2146 RB denotes much
T1059 2147-2151 RBR denotes more
T1060 2152-2161 JJ denotes sensitive
T1061 2162-2164 IN denotes to
T1062 2165-2168 NN denotes DSB
T1064 2169-2175 NN denotes repair
T1066 2175-2176 HYPH denotes –
T1065 2176-2187 JJ denotes independent
T1067 2188-2196 NN denotes synapsis
T1063 2197-2204 NNS denotes defects
T1068 2205-2209 IN denotes than
T1069 2210-2217 NNS denotes oocytes
T1070 2218-2219 -LRB- denotes [
T1071 2219-2221 CD denotes 13
T1072 2221-2222 SYM denotes –
T1073 2222-2224 CD denotes 15
T1074 2224-2225 -RRB- denotes ]
T1075 2225-2226 . denotes .
T1076 2226-2577 sentence denotes However, because recombination is required for synapsis in mice (mutations in recombination genes such as Dmc1 cause extensive asynapsis [16]), it has remained formally uncertain whether there is a distinct pachytene checkpoint that responds to defects in meiotic recombination, and if so, whether it would be identical to that used in somatic cells.
T1077 2227-2234 RB denotes However
T1079 2234-2236 , denotes ,
T1080 2236-2243 IN denotes because
T1082 2244-2257 NN denotes recombination
T1083 2258-2260 VBZ denotes is
T1081 2261-2269 VBN denotes required
T1084 2270-2273 IN denotes for
T1085 2274-2282 NN denotes synapsis
T1086 2283-2285 IN denotes in
T1087 2286-2290 NNS denotes mice
T1088 2291-2292 -LRB- denotes (
T1090 2292-2301 NNS denotes mutations
T1091 2302-2304 IN denotes in
T1092 2305-2318 NN denotes recombination
T1093 2319-2324 NNS denotes genes
T1094 2325-2329 JJ denotes such
T1095 2330-2332 IN denotes as
T1096 2333-2337 NN denotes Dmc1
T1089 2338-2343 VBP denotes cause
T1097 2344-2353 JJ denotes extensive
T1098 2354-2363 NN denotes asynapsis
T1099 2364-2365 -LRB- denotes [
T1100 2365-2367 CD denotes 16
T1101 2367-2368 -RRB- denotes ]
T1102 2368-2369 -RRB- denotes )
T1103 2369-2371 , denotes ,
T1104 2371-2373 PRP denotes it
T1105 2374-2377 VBZ denotes has
T1078 2378-2386 VBN denotes remained
T1106 2387-2395 RB denotes formally
T1107 2396-2405 JJ denotes uncertain
T1108 2406-2413 IN denotes whether
T1110 2414-2419 EX denotes there
T1109 2420-2422 VBZ denotes is
T1111 2423-2424 DT denotes a
T1113 2425-2433 JJ denotes distinct
T1114 2434-2443 NN denotes pachytene
T1112 2444-2454 NN denotes checkpoint
T1115 2455-2459 WDT denotes that
T1116 2460-2468 VBZ denotes responds
T1117 2469-2471 IN denotes to
T1118 2472-2479 NNS denotes defects
T1119 2480-2482 IN denotes in
T1120 2483-2490 JJ denotes meiotic
T1121 2491-2504 NN denotes recombination
T1122 2504-2506 , denotes ,
T1123 2506-2509 CC denotes and
T1124 2510-2512 IN denotes if
T1125 2513-2515 RB denotes so
T1127 2515-2517 , denotes ,
T1128 2517-2524 IN denotes whether
T1129 2525-2527 PRP denotes it
T1130 2528-2533 MD denotes would
T1126 2534-2536 VB denotes be
T1131 2537-2546 JJ denotes identical
T1132 2547-2549 IN denotes to
T1133 2550-2554 DT denotes that
T1134 2555-2559 VBN denotes used
T1135 2560-2562 IN denotes in
T1136 2563-2570 JJ denotes somatic
T1137 2571-2576 NNS denotes cells
T1138 2576-2577 . denotes .
T1139 2577-2717 sentence denotes The mechanisms of putative pachytene checkpoint control remain unknown in mammals, since no mutations have been identified that abolish it.
T1140 2578-2581 DT denotes The
T1141 2582-2592 NNS denotes mechanisms
T1143 2593-2595 IN denotes of
T1144 2596-2604 JJ denotes putative
T1146 2605-2614 NN denotes pachytene
T1147 2615-2625 NN denotes checkpoint
T1145 2626-2633 NN denotes control
T1142 2634-2640 VBP denotes remain
T1148 2641-2648 JJ denotes unknown
T1149 2649-2651 IN denotes in
T1150 2652-2659 NNS denotes mammals
T1151 2659-2661 , denotes ,
T1152 2661-2666 IN denotes since
T1154 2667-2669 DT denotes no
T1155 2670-2679 NNS denotes mutations
T1156 2680-2684 VBP denotes have
T1157 2685-2689 VBN denotes been
T1153 2690-2700 VBN denotes identified
T1158 2701-2705 WDT denotes that
T1159 2706-2713 VBP denotes abolish
T1160 2714-2716 PRP denotes it
T1161 2716-2717 . denotes .
T1162 2717-3042 sentence denotes PCH2, encoding a nucleolar-localized AAA-ATPase that was originally identified in an S. cerevisiae genetic screen for mutants that relieve pachytene arrest of asynaptic zip1 mutants [8], was recently determined to be an essential component of the pachytene synapsis (but not DSB repair) checkpoint in yeast and worms [2,12].
T1163 2718-2722 NN denotes PCH2
T1165 2722-2724 , denotes ,
T1166 2724-2732 VBG denotes encoding
T1167 2733-2734 DT denotes a
T1169 2735-2744 JJ denotes nucleolar
T1171 2744-2745 HYPH denotes -
T1170 2745-2754 VBN denotes localized
T1172 2755-2758 NN denotes AAA
T1173 2758-2759 HYPH denotes -
T1168 2759-2765 NN denotes ATPase
T1174 2766-2770 WDT denotes that
T1176 2771-2774 VBD denotes was
T1177 2775-2785 RB denotes originally
T1175 2786-2796 VBN denotes identified
T1178 2797-2799 IN denotes in
T1179 2800-2802 DT denotes an
T1181 2803-2805 NNP denotes S.
T1182 2806-2816 NNP denotes cerevisiae
T1183 2817-2824 JJ denotes genetic
T1180 2825-2831 NN denotes screen
T1184 2832-2835 IN denotes for
T1185 2836-2843 NNS denotes mutants
T1186 2844-2848 WDT denotes that
T1187 2849-2856 VBP denotes relieve
T1188 2857-2866 NN denotes pachytene
T1189 2867-2873 NN denotes arrest
T1190 2874-2876 IN denotes of
T1191 2877-2886 JJ denotes asynaptic
T1193 2887-2891 NN denotes zip1
T1192 2892-2899 NNS denotes mutants
T1194 2900-2901 -LRB- denotes [
T1195 2901-2902 CD denotes 8
T1196 2902-2903 -RRB- denotes ]
T1197 2903-2905 , denotes ,
T1198 2905-2908 VBD denotes was
T1199 2909-2917 RB denotes recently
T1164 2918-2928 VBN denotes determined
T1200 2929-2931 TO denotes to
T1201 2932-2934 VB denotes be
T1202 2935-2937 DT denotes an
T1204 2938-2947 JJ denotes essential
T1203 2948-2957 NN denotes component
T1205 2958-2960 IN denotes of
T1206 2961-2964 DT denotes the
T1208 2965-2974 NN denotes pachytene
T1209 2975-2983 NN denotes synapsis
T1210 2984-2985 -LRB- denotes (
T1211 2985-2988 CC denotes but
T1212 2989-2992 RB denotes not
T1213 2993-2996 NN denotes DSB
T1214 2997-3003 NN denotes repair
T1215 3003-3004 -RRB- denotes )
T1207 3005-3015 NN denotes checkpoint
T1216 3016-3018 IN denotes in
T1217 3019-3024 NN denotes yeast
T1218 3025-3028 CC denotes and
T1219 3029-3034 NNS denotes worms
T1220 3035-3036 -LRB- denotes [
T1222 3036-3037 CD denotes 2
T1223 3037-3038 , denotes ,
T1221 3038-3040 CD denotes 12
T1224 3040-3041 -RRB- denotes ]
T1225 3041-3042 . denotes .
T1226 3042-3278 sentence denotes PCH2 orthologs are present in organisms that undergo synaptic meiosis, but not asynaptic meiosis, prompting the suggestion that a Pch2-dependent checkpoint evolved to monitor synaptonemal complex (SC) defects from yeast to humans [12].
T1227 3043-3047 NN denotes PCH2
T1228 3048-3057 NNS denotes orthologs
T1229 3058-3061 VBP denotes are
T1230 3062-3069 JJ denotes present
T1231 3070-3072 IN denotes in
T1232 3073-3082 NNS denotes organisms
T1233 3083-3087 WDT denotes that
T1234 3088-3095 VBP denotes undergo
T1235 3096-3104 JJ denotes synaptic
T1236 3105-3112 NN denotes meiosis
T1237 3112-3114 , denotes ,
T1238 3114-3117 CC denotes but
T1239 3118-3121 RB denotes not
T1240 3122-3131 JJ denotes asynaptic
T1241 3132-3139 NN denotes meiosis
T1242 3139-3141 , denotes ,
T1243 3141-3150 VBG denotes prompting
T1244 3151-3154 DT denotes the
T1245 3155-3165 NN denotes suggestion
T1246 3166-3170 IN denotes that
T1248 3171-3172 DT denotes a
T1250 3173-3177 NN denotes Pch2
T1252 3177-3178 HYPH denotes -
T1251 3178-3187 JJ denotes dependent
T1249 3188-3198 NN denotes checkpoint
T1247 3199-3206 VBD denotes evolved
T1253 3207-3209 TO denotes to
T1254 3210-3217 VB denotes monitor
T1255 3218-3230 JJ denotes synaptonemal
T1256 3231-3238 NN denotes complex
T1258 3239-3240 -LRB- denotes (
T1259 3240-3242 NN denotes SC
T1260 3242-3243 -RRB- denotes )
T1257 3244-3251 NNS denotes defects
T1261 3252-3256 IN denotes from
T1262 3257-3262 NN denotes yeast
T1263 3263-3265 IN denotes to
T1264 3266-3272 NNS denotes humans
T1265 3273-3274 -LRB- denotes [
T1266 3274-3276 CD denotes 12
T1267 3276-3277 -RRB- denotes ]
T1268 3277-3278 . denotes .
T1269 3278-3422 sentence denotes Here, we generated mice deficient for the Trip13, the ortholog of PCH2, and evaluated whether it also plays a role in the pachytene checkpoint.
T1270 3279-3283 RB denotes Here
T1272 3283-3285 , denotes ,
T1273 3285-3287 PRP denotes we
T1271 3288-3297 VBD denotes generated
T1274 3298-3302 NNS denotes mice
T1275 3303-3312 JJ denotes deficient
T1276 3313-3316 IN denotes for
T1277 3317-3320 DT denotes the
T1278 3321-3327 NN denotes Trip13
T1279 3327-3329 , denotes ,
T1280 3329-3332 DT denotes the
T1281 3333-3341 NN denotes ortholog
T1282 3342-3344 IN denotes of
T1283 3345-3349 NN denotes PCH2
T1284 3349-3351 , denotes ,
T1285 3351-3354 CC denotes and
T1286 3355-3364 VBD denotes evaluated
T1287 3365-3372 IN denotes whether
T1289 3373-3375 PRP denotes it
T1290 3376-3380 RB denotes also
T1288 3381-3386 VBZ denotes plays
T1291 3387-3388 DT denotes a
T1292 3389-3393 NN denotes role
T1293 3394-3396 IN denotes in
T1294 3397-3400 DT denotes the
T1296 3401-3410 NN denotes pachytene
T1295 3411-3421 NN denotes checkpoint
T1297 3421-3422 . denotes .
T1298 3422-3583 sentence denotes Surprisingly, while we found no evidence for checkpoint function, we did uncover a potential role for this protein in noncrossover (NCO) repair of meiotic DSBs.
T1299 3423-3435 RB denotes Surprisingly
T1301 3435-3437 , denotes ,
T1302 3437-3442 IN denotes while
T1304 3443-3445 PRP denotes we
T1303 3446-3451 VBD denotes found
T1305 3452-3454 DT denotes no
T1306 3455-3463 NN denotes evidence
T1307 3464-3467 IN denotes for
T1308 3468-3478 NN denotes checkpoint
T1309 3479-3487 NN denotes function
T1310 3487-3489 , denotes ,
T1311 3489-3491 PRP denotes we
T1312 3492-3495 VBD denotes did
T1300 3496-3503 VB denotes uncover
T1313 3504-3505 DT denotes a
T1315 3506-3515 JJ denotes potential
T1314 3516-3520 NN denotes role
T1316 3521-3524 IN denotes for
T1317 3525-3529 DT denotes this
T1318 3530-3537 NN denotes protein
T1319 3538-3540 IN denotes in
T1320 3541-3553 JJ denotes noncrossover
T1322 3554-3555 -LRB- denotes (
T1321 3555-3558 JJ denotes NCO
T1324 3558-3559 -RRB- denotes )
T1323 3560-3566 NN denotes repair
T1325 3567-3569 IN denotes of
T1326 3570-3577 JJ denotes meiotic
T1327 3578-3582 NNS denotes DSBs
T1328 3582-3583 . denotes .
R251 T668 T669 det The,genesis
R252 T669 T670 nsubj genesis,is
R253 T671 T669 prep of,genesis
R254 T672 T671 pobj gametes,of
R255 T673 T672 acl containing,gametes
R256 T674 T675 det an,genome
R257 T675 T673 dobj genome,containing
R258 T676 T675 amod intact,genome
R259 T677 T675 punct ", ",genome
R260 T678 T675 amod haploid,genome
R261 T679 T670 acomp critical,is
R262 T680 T679 prep for,critical
R263 T681 T682 det the,prevention
R264 T682 T680 pobj prevention,for
R265 T683 T682 prep of,prevention
R266 T684 T685 compound birth,defects
R267 T685 T683 pobj defects,of
R268 T686 T670 punct ", ",is
R269 T687 T670 cc and,is
R270 T688 T670 conj is,is
R271 T689 T690 advmod highly,dependent
R272 T690 T688 acomp dependent,is
R273 T691 T690 prep upon,dependent
R274 T692 T693 det the,fidelity
R275 T693 T691 pobj fidelity,upon
R276 T694 T693 prep of,fidelity
R277 T695 T696 compound chromosome,dynamics
R278 T696 T694 pobj dynamics,of
R279 T697 T688 prep before,is
R280 T698 T699 det the,division
R281 T699 T697 pobj division,before
R282 T700 T699 amod first,division
R283 T701 T699 amod meiotic,division
R284 T702 T670 punct .,is
R285 T704 T705 amod Homologous,chromosomes
R286 T705 T706 nsubj chromosomes,pair
R287 T707 T706 aux must,pair
R288 T708 T706 punct ", ",pair
R289 T709 T706 conj synapse,pair
R290 T710 T709 punct ", ",synapse
R291 T711 T709 conj undergo,synapse
R292 T712 T711 dobj recombination,undergo
R293 T713 T711 punct ", ",undergo
R294 T714 T711 cc and,undergo
R295 T715 T711 conj segregate,undergo
R296 T716 T715 advmod properly,segregate
R297 T717 T715 prep to,segregate
R298 T718 T719 amod opposite,poles
R299 T719 T717 pobj poles,to
R300 T720 T706 punct .,pair
R301 T722 T723 nsubjpass Recombination,coupled
R302 T724 T722 punct ", ",Recombination
R303 T725 T726 dep which,repairs
R304 T726 T722 relcl repairs,Recombination
R305 T727 T728 nmod repair,breaks
R306 T728 T726 dobj breaks,repairs
R307 T729 T730 amod double,strand
R308 T730 T728 compound strand,breaks
R309 T731 T728 punct (,breaks
R310 T732 T728 appos DSBs,breaks
R311 T733 T728 punct ),breaks
R312 T734 T735 dep that,induced
R313 T735 T728 relcl induced,breaks
R314 T736 T735 auxpass are,induced
R315 T737 T735 advmod genetically,induced
R316 T738 T726 prep in,repairs
R317 T739 T738 pobj leptonema,in
R318 T740 T723 punct ", ",coupled
R319 T741 T723 auxpass is,coupled
R320 T742 T723 prep with,coupled
R321 T743 T742 pobj synapsis,with
R322 T744 T723 prep in,coupled
R323 T745 T746 amod budding,yeast
R324 T746 T744 pobj yeast,in
R325 T747 T746 cc and,yeast
R326 T748 T746 conj mammals,yeast
R327 T749 T723 punct .,coupled
R328 T751 T752 mark While,is
R329 T752 T763 advcl is,known
R330 T753 T754 poss our,knowledge
R331 T754 T752 nsubj knowledge,is
R332 T755 T754 prep of,knowledge
R333 T756 T757 det the,assembly
R334 T757 T755 pobj assembly,of
R335 T758 T757 cc and,assembly
R336 T759 T757 conj nature,assembly
R337 T760 T757 prep of,assembly
R338 T761 T762 compound recombination,machinery
R339 T762 T760 pobj machinery,of
R340 T764 T752 acomp extensive,is
R341 T765 T763 punct ", ",known
R342 T766 T763 nsubjpass little,known
R343 T767 T763 auxpass is,known
R344 T768 T763 prep about,known
R345 T769 T770 det the,disassembly
R346 T770 T768 pobj disassembly,about
R347 T771 T770 prep of,disassembly
R348 T772 T773 compound recombination,intermediates
R349 T773 T771 pobj intermediates,of
R350 T774 T770 punct ", ",disassembly
R351 T775 T770 conj recruitment,disassembly
R352 T776 T775 prep of,recruitment
R353 T777 T778 compound DNA,machinery
R354 T778 T776 pobj machinery,of
R355 T779 T778 compound replication,machinery
R356 T780 T775 prep during,recruitment
R357 T781 T782 amod recombinational,repair
R358 T782 T780 pobj repair,during
R359 T783 T775 punct ", ",recruitment
R360 T784 T775 cc and,recruitment
R361 T785 T786 advmod how,made
R362 T786 T775 conj made,recruitment
R363 T787 T788 det the,choice
R364 T788 T786 nsubjpass choice,made
R365 T789 T788 prep between,choice
R366 T790 T791 amod different,pathways
R367 T791 T789 pobj pathways,between
R368 T792 T791 compound repair,pathways
R369 T793 T786 auxpass is,made
R370 T794 T763 punct .,known
R371 T796 T797 nsubj Defects,preclude
R372 T798 T796 prep in,Defects
R373 T799 T798 pobj recombination,in
R374 T800 T797 aux can,preclude
R375 T801 T802 amod homologous,pairing
R376 T802 T797 dobj pairing,preclude
R377 T803 T802 compound chromosome,pairing
R378 T804 T797 punct ", ",preclude
R379 T805 T797 conj leave,preclude
R380 T806 T807 amod unrepaired,breaks
R381 T807 T805 dobj breaks,leave
R382 T808 T807 compound chromosome,breaks
R383 T809 T805 punct ", ",leave
R384 T810 T805 cc and,leave
R385 T811 T805 conj cause,leave
R386 T812 T811 dobj aneuploidy,cause
R387 T813 T811 prep by,cause
R388 T814 T813 pcomp abrogating,by
R389 T815 T814 xcomp crossing,abrogating
R390 T816 T815 prt over,crossing
R391 T817 T797 punct .,preclude
R392 T819 T820 aux To,avoid
R393 T820 T821 advcl avoid,exist
R394 T822 T823 amod such,outcomes
R395 T823 T820 dobj outcomes,avoid
R396 T824 T823 amod deleterious,outcomes
R397 T825 T821 punct ", ",exist
R398 T826 T827 compound surveillance,systems
R399 T827 T821 nsubj systems,exist
R400 T828 T827 punct (,systems
R401 T829 T827 punct “,systems
R402 T830 T827 appos checkpoints,systems
R403 T831 T821 punct ”,exist
R404 T832 T821 punct ),exist
R405 T833 T834 aux to,sense
R406 T834 T821 advcl sense,exist
R407 T835 T836 amod meiotic,errors
R408 T836 T834 dobj errors,sense
R409 T837 T834 cc and,sense
R410 T838 T834 conj eliminate,sense
R411 T839 T838 dobj cells,eliminate
R412 T840 T839 acl containing,cells
R413 T841 T842 amod unresolved,defects
R414 T842 T840 dobj defects,containing
R415 T843 T821 punct .,exist
R416 T845 T846 prep In,trigger
R417 T847 T848 amod many,organisms
R418 T848 T845 pobj organisms,In
R419 T849 T848 punct ", ",organisms
R420 T850 T848 prep including,organisms
R421 T851 T852 compound S.,cerevisiae
R422 T852 T850 pobj cerevisiae,including
R423 T853 T852 punct ", ",cerevisiae
R424 T854 T855 compound Drosophila,melanogaster
R425 T855 T852 conj melanogaster,cerevisiae
R426 T856 T855 punct ", ",melanogaster
R427 T857 T858 compound C.,elegans
R428 T858 T855 conj elegans,melanogaster
R429 T859 T858 punct ", ",elegans
R430 T860 T858 cc and,elegans
R431 T861 T858 conj mice,elegans
R432 T862 T863 punct [,1
R433 T863 T861 parataxis 1,mice
R434 T864 T865 punct –,4
R435 T865 T863 prep 4,1
R436 T866 T863 punct ],1
R437 T867 T846 punct ", ",trigger
R438 T868 T846 nsubj meiocytes,trigger
R439 T869 T868 prep with,meiocytes
R440 T870 T869 pobj defects,with
R441 T871 T870 prep in,defects
R442 T872 T871 pobj recombination,in
R443 T873 T872 cc and,recombination
R444 T874 T873 punct /,and
R445 T875 T873 cc or,and
R446 T876 T877 compound chromosome,synapsis
R447 T877 T872 conj synapsis,recombination
R448 T878 T879 amod meiotic,arrest
R449 T879 T846 dobj arrest,trigger
R450 T880 T846 prep in,trigger
R451 T881 T882 det the,stage
R452 T882 T880 pobj stage,in
R453 T883 T882 compound pachytene,stage
R454 T884 T882 prep of,stage
R455 T885 T886 amod meiotic,prophase
R456 T886 T884 pobj prophase,of
R457 T887 T886 nummod I,prophase
R458 T888 T846 punct .,trigger
R459 T890 T891 det This,response
R460 T891 T892 nsubjpass response,referred
R461 T893 T891 prep to,response
R462 T894 T895 amod meiotic,defects
R463 T895 T893 pobj defects,to
R464 T896 T892 auxpass is,referred
R465 T897 T892 prep to,referred
R466 T898 T892 prep as,referred
R467 T899 T900 det the,checkpoint
R468 T900 T898 pobj checkpoint,as
R469 T901 T900 punct “,checkpoint
R470 T902 T900 compound pachytene,checkpoint
R471 T903 T892 dep ”,referred
R472 T904 T905 punct (,reviewed
R473 T905 T892 parataxis reviewed,referred
R474 T906 T905 prep in,reviewed
R475 T907 T908 punct [,5
R476 T908 T906 pobj 5,in
R477 T909 T908 punct ],5
R478 T910 T905 punct ),reviewed
R479 T911 T892 punct .,referred
R480 T913 T914 amod Genetic,experiments
R481 T914 T915 nsubj experiments,identified
R482 T916 T914 prep in,experiments
R483 T917 T918 compound S.,cerevisiae
R484 T918 T916 pobj cerevisiae,in
R485 T919 T915 aux have,identified
R486 T920 T915 dobj elements,identified
R487 T921 T920 prep of,elements
R488 T922 T923 det the,machinery
R489 T923 T921 pobj machinery,of
R490 T924 T923 compound pachytene,machinery
R491 T925 T923 compound checkpoint,machinery
R492 T926 T927 punct (,reviewed
R493 T927 T915 parataxis reviewed,identified
R494 T928 T927 prep in,reviewed
R495 T929 T930 punct [,5
R496 T930 T928 pobj 5,in
R497 T931 T930 punct ],5
R498 T932 T927 punct ),reviewed
R499 T933 T915 punct .,identified
R500 T935 T936 prep In,include
R501 T937 T935 pobj addition,In
R502 T938 T937 prep to,addition
R503 T939 T940 npadvmod meiosis,specific
R504 T940 T942 amod specific,proteins
R505 T941 T940 punct -,specific
R506 T942 T938 pobj proteins,to
R507 T943 T936 punct ", ",include
R508 T944 T936 nsubj these,include
R509 T945 T936 dobj factors,include
R510 T946 T947 dep that,play
R511 T947 T945 relcl play,factors
R512 T948 T947 dobj roles,play
R513 T949 T947 prep in,play
R514 T950 T951 compound DNA,damage
R515 T951 T952 compound damage,signaling
R516 T952 T949 pobj signaling,in
R517 T953 T952 prep in,signaling
R518 T954 T955 amod mitotic,cells
R519 T955 T953 pobj cells,in
R520 T956 T957 punct [,6
R521 T957 T936 parataxis 6,include
R522 T958 T959 punct –,10
R523 T959 T957 prep 10,6
R524 T960 T957 punct ],6
R525 T961 T936 punct .,include
R526 T963 T964 compound Arabidopsis,thaliana
R527 T964 T965 nsubj thaliana,appear
R528 T966 T965 aux does,appear
R529 T967 T965 neg not,appear
R530 T968 T969 aux to,have
R531 T969 T965 xcomp have,appear
R532 T970 T971 det a,checkpoint
R533 T971 T969 dobj checkpoint,have
R534 T972 T971 compound pachytene,checkpoint
R535 T973 T971 amod akin,checkpoint
R536 T974 T973 prep to,akin
R537 T975 T974 pobj that,to
R538 T976 T975 prep in,that
R539 T977 T976 pobj yeast,in
R540 T978 T979 punct [,11
R541 T979 T969 parataxis 11,have
R542 T980 T979 punct ],11
R543 T981 T965 punct ", ",appear
R544 T982 T965 cc nor,appear
R545 T983 T965 conj do,appear
R546 T984 T985 amod male,Drosophila
R547 T985 T983 nsubj Drosophila,do
R548 T986 T983 punct .,do
R549 T988 T989 det The,checkpoint
R550 T989 T991 nsubjpass checkpoint,known
R551 T990 T989 compound pachytene,checkpoint
R552 T992 T991 auxpass is,known
R553 T993 T994 aux to,monitor
R554 T994 T991 xcomp monitor,known
R555 T995 T996 nummod two,aspects
R556 T996 T994 dobj aspects,monitor
R557 T997 T996 prep of,aspects
R558 T998 T999 amod meiotic,metabolism
R559 T999 T997 pobj metabolism,of
R560 T1000 T999 compound chromosome,metabolism
R561 T1001 T999 prep in,metabolism
R562 T1002 T1003 compound S.,cerevisiae
R563 T1003 T1001 pobj cerevisiae,in
R564 T1004 T1003 cc and,cerevisiae
R565 T1005 T1006 compound C.,elegans
R566 T1006 T1003 conj elegans,cerevisiae
R567 T1007 T996 punct : ,aspects
R568 T1008 T1009 punct (,1
R569 T1009 T1010 meta 1,repair
R570 T1010 T996 appos repair,aspects
R571 T1011 T1009 punct ),1
R572 T1012 T1010 compound DSB,repair
R573 T1013 T1010 cc and,repair
R574 T1014 T1015 punct (,2
R575 T1015 T1016 meta 2,synapsis
R576 T1016 T1010 conj synapsis,repair
R577 T1017 T1015 punct ),2
R578 T1018 T1016 compound chromosome,synapsis
R579 T1019 T1020 punct [,12
R580 T1020 T991 parataxis 12,known
R581 T1021 T1020 nummod 2,12
R582 T1022 T1020 punct ",",12
R583 T1023 T1020 punct ],12
R584 T1024 T991 punct .,known
R585 T1026 T1027 prep In,eliminated
R586 T1028 T1026 pobj mice,In
R587 T1029 T1027 punct ", ",eliminated
R588 T1030 T1031 preconj both,spermatocytes
R589 T1031 T1027 nsubjpass spermatocytes,eliminated
R590 T1032 T1031 cc and,spermatocytes
R591 T1033 T1031 conj oocytes,spermatocytes
R592 T1034 T1031 acl harboring,spermatocytes
R593 T1035 T1034 dobj mutations,harboring
R594 T1036 T1037 dep that,disrupt
R595 T1037 T1035 relcl disrupt,mutations
R596 T1038 T1039 compound DSB,repair
R597 T1039 T1037 dobj repair,disrupt
R598 T1040 T1035 punct (,mutations
R599 T1041 T1042 amod such,as
R600 T1042 T1035 prep as,mutations
R601 T1043 T1042 pobj Dmc1,as
R602 T1044 T1043 punct ", ",Dmc1
R603 T1045 T1043 conj Msh5,Dmc1
R604 T1046 T1045 punct ", ",Msh5
R605 T1047 T1045 cc and,Msh5
R606 T1048 T1045 conj Atm,Msh5
R607 T1049 T1027 punct ),eliminated
R608 T1050 T1027 auxpass are,eliminated
R609 T1051 T1027 advmod efficiently,eliminated
R610 T1052 T1027 prep in,eliminated
R611 T1053 T1052 pobj pachynema,in
R612 T1054 T1027 punct ", ",eliminated
R613 T1055 T1027 cc but,eliminated
R614 T1056 T1057 nsubj spermatocytes,are
R615 T1057 T1027 conj are,eliminated
R616 T1058 T1059 advmod much,more
R617 T1059 T1060 advmod more,sensitive
R618 T1060 T1057 acomp sensitive,are
R619 T1061 T1060 prep to,sensitive
R620 T1062 T1063 nmod DSB,defects
R621 T1063 T1061 pobj defects,to
R622 T1064 T1065 npadvmod repair,independent
R623 T1065 T1067 amod independent,synapsis
R624 T1066 T1065 punct –,independent
R625 T1067 T1063 compound synapsis,defects
R626 T1068 T1060 prep than,sensitive
R627 T1069 T1068 pobj oocytes,than
R628 T1070 T1071 punct [,13
R629 T1071 T1027 parataxis 13,eliminated
R630 T1072 T1073 punct –,15
R631 T1073 T1071 prep 15,13
R632 T1074 T1071 punct ],13
R633 T1075 T1027 punct .,eliminated
R634 T1077 T1078 advmod However,remained
R635 T1079 T1078 punct ", ",remained
R636 T1080 T1081 mark because,required
R637 T1081 T1078 advcl required,remained
R638 T1082 T1081 nsubjpass recombination,required
R639 T1083 T1081 auxpass is,required
R640 T1084 T1081 prep for,required
R641 T1085 T1084 pobj synapsis,for
R642 T1086 T1085 prep in,synapsis
R643 T1087 T1086 pobj mice,in
R644 T1088 T1089 punct (,cause
R645 T1089 T1081 parataxis cause,required
R646 T1090 T1089 nsubj mutations,cause
R647 T1091 T1090 prep in,mutations
R648 T1092 T1093 compound recombination,genes
R649 T1093 T1091 pobj genes,in
R650 T1094 T1095 amod such,as
R651 T1095 T1093 prep as,genes
R652 T1096 T1095 pobj Dmc1,as
R653 T1097 T1098 amod extensive,asynapsis
R654 T1098 T1089 dobj asynapsis,cause
R655 T1099 T1100 punct [,16
R656 T1100 T1089 parataxis 16,cause
R657 T1101 T1100 punct ],16
R658 T1102 T1089 punct ),cause
R659 T1103 T1078 punct ", ",remained
R660 T1104 T1078 nsubj it,remained
R661 T1105 T1078 aux has,remained
R662 T1106 T1107 advmod formally,uncertain
R663 T1107 T1078 acomp uncertain,remained
R664 T1108 T1109 mark whether,is
R665 T1109 T1078 advcl is,remained
R666 T1110 T1109 expl there,is
R667 T1111 T1112 det a,checkpoint
R668 T1112 T1109 attr checkpoint,is
R669 T1113 T1112 amod distinct,checkpoint
R670 T1114 T1112 compound pachytene,checkpoint
R671 T1115 T1116 dep that,responds
R672 T1116 T1112 relcl responds,checkpoint
R673 T1117 T1116 prep to,responds
R674 T1118 T1117 pobj defects,to
R675 T1119 T1118 prep in,defects
R676 T1120 T1121 amod meiotic,recombination
R677 T1121 T1119 pobj recombination,in
R678 T1122 T1109 punct ", ",is
R679 T1123 T1109 cc and,is
R680 T1124 T1125 mark if,so
R681 T1125 T1126 advcl so,be
R682 T1126 T1109 conj be,is
R683 T1127 T1126 punct ", ",be
R684 T1128 T1126 mark whether,be
R685 T1129 T1126 nsubj it,be
R686 T1130 T1126 aux would,be
R687 T1131 T1126 acomp identical,be
R688 T1132 T1131 prep to,identical
R689 T1133 T1132 pobj that,to
R690 T1134 T1133 acl used,that
R691 T1135 T1134 prep in,used
R692 T1136 T1137 amod somatic,cells
R693 T1137 T1135 pobj cells,in
R694 T1138 T1078 punct .,remained
R695 T1140 T1141 det The,mechanisms
R696 T1141 T1142 nsubj mechanisms,remain
R697 T1143 T1141 prep of,mechanisms
R698 T1144 T1145 amod putative,control
R699 T1145 T1143 pobj control,of
R700 T1146 T1147 compound pachytene,checkpoint
R701 T1147 T1145 compound checkpoint,control
R702 T1148 T1142 acomp unknown,remain
R703 T1149 T1142 prep in,remain
R704 T1150 T1149 pobj mammals,in
R705 T1151 T1142 punct ", ",remain
R706 T1152 T1153 mark since,identified
R707 T1153 T1142 advcl identified,remain
R708 T1154 T1155 det no,mutations
R709 T1155 T1153 nsubjpass mutations,identified
R710 T1156 T1153 aux have,identified
R711 T1157 T1153 auxpass been,identified
R712 T1158 T1159 dep that,abolish
R713 T1159 T1153 ccomp abolish,identified
R714 T1160 T1159 dobj it,abolish
R715 T1161 T1142 punct .,remain
R716 T1163 T1164 nsubjpass PCH2,determined
R717 T1165 T1163 punct ", ",PCH2
R718 T1166 T1163 acl encoding,PCH2
R719 T1167 T1168 det a,ATPase
R720 T1168 T1166 dobj ATPase,encoding
R721 T1169 T1170 amod nucleolar,localized
R722 T1170 T1168 amod localized,ATPase
R723 T1171 T1170 punct -,localized
R724 T1172 T1168 compound AAA,ATPase
R725 T1173 T1168 punct -,ATPase
R726 T1174 T1175 dep that,identified
R727 T1175 T1166 ccomp identified,encoding
R728 T1176 T1175 auxpass was,identified
R729 T1177 T1175 advmod originally,identified
R730 T1178 T1175 prep in,identified
R731 T1179 T1180 det an,screen
R732 T1180 T1178 pobj screen,in
R733 T1181 T1182 nmod S.,cerevisiae
R734 T1182 T1180 nmod cerevisiae,screen
R735 T1183 T1180 amod genetic,screen
R736 T1184 T1175 prep for,identified
R737 T1185 T1184 pobj mutants,for
R738 T1186 T1187 dep that,relieve
R739 T1187 T1185 relcl relieve,mutants
R740 T1188 T1189 compound pachytene,arrest
R741 T1189 T1187 dobj arrest,relieve
R742 T1190 T1189 prep of,arrest
R743 T1191 T1192 amod asynaptic,mutants
R744 T1192 T1190 pobj mutants,of
R745 T1193 T1192 compound zip1,mutants
R746 T1194 T1195 punct [,8
R747 T1195 T1175 parataxis 8,identified
R748 T1196 T1195 punct ],8
R749 T1197 T1164 punct ", ",determined
R750 T1198 T1164 auxpass was,determined
R751 T1199 T1164 advmod recently,determined
R752 T1200 T1201 aux to,be
R753 T1201 T1164 xcomp be,determined
R754 T1202 T1203 det an,component
R755 T1203 T1201 attr component,be
R756 T1204 T1203 amod essential,component
R757 T1205 T1203 prep of,component
R758 T1206 T1207 det the,checkpoint
R759 T1207 T1205 pobj checkpoint,of
R760 T1208 T1209 nmod pachytene,synapsis
R761 T1209 T1207 nmod synapsis,checkpoint
R762 T1210 T1209 punct (,synapsis
R763 T1211 T1209 cc but,synapsis
R764 T1212 T1211 neg not,but
R765 T1213 T1214 compound DSB,repair
R766 T1214 T1209 conj repair,synapsis
R767 T1215 T1207 punct ),checkpoint
R768 T1216 T1207 prep in,checkpoint
R769 T1217 T1216 pobj yeast,in
R770 T1218 T1217 cc and,yeast
R771 T1219 T1217 conj worms,yeast
R772 T1220 T1221 punct [,12
R773 T1221 T1164 parataxis 12,determined
R774 T1222 T1221 nummod 2,12
R775 T1223 T1221 punct ",",12
R776 T1224 T1221 punct ],12
R777 T1225 T1164 punct .,determined
R778 T1227 T1228 compound PCH2,orthologs
R779 T1228 T1229 nsubj orthologs,are
R780 T1230 T1229 acomp present,are
R781 T1231 T1229 prep in,are
R782 T1232 T1231 pobj organisms,in
R783 T1233 T1234 dep that,undergo
R784 T1234 T1232 relcl undergo,organisms
R785 T1235 T1236 amod synaptic,meiosis
R786 T1236 T1234 dobj meiosis,undergo
R787 T1237 T1236 punct ", ",meiosis
R788 T1238 T1236 cc but,meiosis
R789 T1239 T1238 neg not,but
R790 T1240 T1241 amod asynaptic,meiosis
R791 T1241 T1236 conj meiosis,meiosis
R792 T1242 T1229 punct ", ",are
R793 T1243 T1229 advcl prompting,are
R794 T1244 T1245 det the,suggestion
R795 T1245 T1243 dobj suggestion,prompting
R796 T1246 T1247 mark that,evolved
R797 T1247 T1245 acl evolved,suggestion
R798 T1248 T1249 det a,checkpoint
R799 T1249 T1247 nsubj checkpoint,evolved
R800 T1250 T1251 npadvmod Pch2,dependent
R801 T1251 T1249 amod dependent,checkpoint
R802 T1252 T1251 punct -,dependent
R803 T1253 T1254 aux to,monitor
R804 T1254 T1247 advcl monitor,evolved
R805 T1255 T1256 amod synaptonemal,complex
R806 T1256 T1257 nmod complex,defects
R807 T1257 T1254 dobj defects,monitor
R808 T1258 T1256 punct (,complex
R809 T1259 T1256 appos SC,complex
R810 T1260 T1257 punct ),defects
R811 T1261 T1257 prep from,defects
R812 T1262 T1261 pobj yeast,from
R813 T1263 T1257 prep to,defects
R814 T1264 T1263 pobj humans,to
R815 T1265 T1266 punct [,12
R816 T1266 T1229 parataxis 12,are
R817 T1267 T1266 punct ],12
R818 T1268 T1229 punct .,are
R819 T1270 T1271 advmod Here,generated
R820 T1272 T1271 punct ", ",generated
R821 T1273 T1271 nsubj we,generated
R822 T1274 T1271 dobj mice,generated
R823 T1275 T1274 amod deficient,mice
R824 T1276 T1275 prep for,deficient
R825 T1277 T1278 det the,Trip13
R826 T1278 T1276 pobj Trip13,for
R827 T1279 T1278 punct ", ",Trip13
R828 T1280 T1281 det the,ortholog
R829 T1281 T1278 appos ortholog,Trip13
R830 T1282 T1281 prep of,ortholog
R831 T1283 T1282 pobj PCH2,of
R832 T1284 T1271 punct ", ",generated
R833 T1285 T1271 cc and,generated
R834 T1286 T1271 conj evaluated,generated
R835 T1287 T1288 mark whether,plays
R836 T1288 T1286 ccomp plays,evaluated
R837 T1289 T1288 nsubj it,plays
R838 T1290 T1288 advmod also,plays
R839 T1291 T1292 det a,role
R840 T1292 T1288 dobj role,plays
R841 T1293 T1288 prep in,plays
R842 T1294 T1295 det the,checkpoint
R843 T1295 T1293 pobj checkpoint,in
R844 T1296 T1295 compound pachytene,checkpoint
R845 T1297 T1271 punct .,generated
R846 T1299 T1300 advmod Surprisingly,uncover
R847 T1301 T1300 punct ", ",uncover
R848 T1302 T1303 mark while,found
R849 T1303 T1300 advcl found,uncover
R850 T1304 T1303 nsubj we,found
R851 T1305 T1306 det no,evidence
R852 T1306 T1303 dobj evidence,found
R853 T1307 T1303 prep for,found
R854 T1308 T1309 compound checkpoint,function
R855 T1309 T1307 pobj function,for
R856 T1310 T1300 punct ", ",uncover
R857 T1311 T1300 nsubj we,uncover
R858 T1312 T1300 aux did,uncover
R859 T1313 T1314 det a,role
R860 T1314 T1300 dobj role,uncover
R861 T1315 T1314 amod potential,role
R862 T1316 T1314 prep for,role
R863 T1317 T1318 det this,protein
R864 T1318 T1316 pobj protein,for
R865 T1319 T1314 prep in,role
R866 T1320 T1321 amod noncrossover,NCO
R867 T1321 T1323 amod NCO,repair
R868 T1322 T1321 punct (,NCO
R869 T1323 T1319 pobj repair,in
R870 T1324 T1323 punct ),repair
R871 T1325 T1323 prep of,repair
R872 T1326 T1327 amod meiotic,DSBs
R873 T1327 T1325 pobj DSBs,of
R874 T1328 T1300 punct .,uncover