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PMC:1941754 / 23325-24407 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T4145 0-3 DT denotes The
T4146 4-15 NN denotes persistence
T4148 16-18 IN denotes of
T4149 19-22 NN denotes BLM
T4150 23-25 IN denotes on
T4151 26-34 NN denotes Trip13Gt
T4153 34-35 HYPH denotes /
T4152 35-37 NN denotes Gt
T4154 38-50 NN denotes spermatocyte
T4155 51-62 NNS denotes chromosomes
T4147 63-71 VBZ denotes suggests
T4156 72-76 IN denotes that
T4158 77-79 RB denotes at
T4159 80-85 RBS denotes least
T4161 86-87 DT denotes a
T4160 88-94 NN denotes subset
T4162 95-97 IN denotes of
T4163 98-101 DT denotes the
T4165 102-112 JJ denotes unrepaired
T4164 113-117 NNS denotes DSBs
T4157 118-128 VBP denotes correspond
T4166 129-131 IN denotes to
T4167 132-137 NNS denotes sites
T4168 138-140 IN denotes of
T4169 141-150 JJ denotes defective
T4171 151-154 NN denotes NCO
T4172 155-170 JJ denotes recombinational
T4170 171-177 NN denotes repair
T4173 177-178 . denotes .
T4174 178-416 sentence denotes To assess whether CO recombination occurs in the mutant, we examined the distribution of the mismatch repair proteins MLH1 and MLH3, which are normally detectable as foci in mid-late pachynema and mark the locations of chiasmata [30,31].
T4175 179-181 TO denotes To
T4176 182-188 VB denotes assess
T4178 189-196 IN denotes whether
T4180 197-199 NN denotes CO
T4181 200-213 NN denotes recombination
T4179 214-220 VBZ denotes occurs
T4182 221-223 IN denotes in
T4183 224-227 DT denotes the
T4184 228-234 NN denotes mutant
T4185 234-236 , denotes ,
T4186 236-238 PRP denotes we
T4177 239-247 VBD denotes examined
T4187 248-251 DT denotes the
T4188 252-264 NN denotes distribution
T4189 265-267 IN denotes of
T4190 268-271 DT denotes the
T4192 272-280 NN denotes mismatch
T4193 281-287 NN denotes repair
T4191 288-296 NN denotes proteins
T4194 297-301 NN denotes MLH1
T4195 302-305 CC denotes and
T4196 306-310 NN denotes MLH3
T4197 310-312 , denotes ,
T4198 312-317 WDT denotes which
T4199 318-321 VBP denotes are
T4200 322-330 RB denotes normally
T4201 331-341 JJ denotes detectable
T4202 342-344 IN denotes as
T4203 345-349 NNS denotes foci
T4204 350-352 IN denotes in
T4205 353-356 JJ denotes mid
T4207 356-357 SYM denotes -
T4206 357-361 JJ denotes late
T4208 362-371 NN denotes pachynema
T4209 372-375 CC denotes and
T4210 376-380 VBP denotes mark
T4211 381-384 DT denotes the
T4212 385-394 NNS denotes locations
T4213 395-397 IN denotes of
T4214 398-407 NNS denotes chiasmata
T4215 408-409 -LRB- denotes [
T4217 409-411 CD denotes 30
T4218 411-412 , denotes ,
T4216 412-414 CD denotes 31
T4219 414-415 -RRB- denotes ]
T4220 415-416 . denotes .
T4221 416-634 sentence denotes Remarkably, MLH1/3 foci were formed; we observed 1–2 foci/chromosome as in wild type and at typical overall levels (MLH3 = 23 ± 2, N = 10; [30,32]) on mid-late pachytene chromosomes (Figure 4M and 4N; MLH1 not shown).
T4222 417-427 RB denotes Remarkably
T4224 427-429 , denotes ,
T4225 429-433 NN denotes MLH1
T4227 433-434 HYPH denotes /
T4228 434-435 CD denotes 3
T4226 436-440 NNS denotes foci
T4229 441-445 VBD denotes were
T4223 446-452 VBN denotes formed
T4231 452-453 : denotes ;
T4232 454-456 PRP denotes we
T4230 457-465 VBD denotes observed
T4233 466-467 CD denotes 1
T4235 467-468 SYM denotes –
T4234 468-469 CD denotes 2
T4236 470-474 NNS denotes foci
T4237 474-475 SYM denotes /
T4238 475-485 NN denotes chromosome
T4239 486-488 IN denotes as
T4240 489-491 IN denotes in
T4241 492-496 JJ denotes wild
T4242 497-501 NN denotes type
T4243 502-505 CC denotes and
T4244 506-508 IN denotes at
T4245 509-516 JJ denotes typical
T4247 517-524 JJ denotes overall
T4246 525-531 NNS denotes levels
T4248 532-533 -LRB- denotes (
T4250 533-537 NN denotes MLH3
T4252 538-539 SYM denotes =
T4253 540-542 CD denotes 23
T4254 543-544 SYM denotes ±
T4251 545-546 CD denotes 2
T4255 546-548 , denotes ,
T4256 548-549 NN denotes N
T4257 550-551 SYM denotes =
T4249 552-554 CD denotes 10
T4258 554-555 : denotes ;
T4259 556-557 -LRB- denotes [
T4261 557-559 CD denotes 30
T4262 559-560 , denotes ,
T4260 560-562 CD denotes 32
T4263 562-563 -RRB- denotes ]
T4264 563-564 -RRB- denotes )
T4265 565-567 IN denotes on
T4266 568-571 JJ denotes mid
T4268 571-572 SYM denotes -
T4267 572-576 JJ denotes late
T4269 577-586 NN denotes pachytene
T4270 587-598 NNS denotes chromosomes
T4271 599-600 -LRB- denotes (
T4273 600-606 NN denotes Figure
T4272 607-609 NN denotes 4M
T4274 610-613 CC denotes and
T4275 614-616 NN denotes 4N
T4276 616-617 : denotes ;
T4277 618-622 NN denotes MLH1
T4279 623-626 RB denotes not
T4278 627-632 VBN denotes shown
T4280 632-633 -RRB- denotes )
T4281 633-634 . denotes .
T4282 634-902 sentence denotes Since <1% of Trip13Gt/Gt pachytene nuclei had normal repair (as judged by absence of persistent DSB repair markers; see above), but most of the pachytene nuclei had MLH1/3 foci, it was unlikely that the MLH1/3 foci formed only on chromosomes with fully repaired DSBs.
T4283 635-640 IN denotes Since
T4285 641-642 SYM denotes <
T4286 642-643 CD denotes 1
T4287 643-644 NN denotes %
T4288 645-647 IN denotes of
T4289 648-656 NN denotes Trip13Gt
T4291 656-657 HYPH denotes /
T4290 657-659 NN denotes Gt
T4292 660-669 NN denotes pachytene
T4293 670-676 NNS denotes nuclei
T4284 677-680 VBD denotes had
T4295 681-687 JJ denotes normal
T4296 688-694 NN denotes repair
T4297 695-696 -LRB- denotes (
T4299 696-698 IN denotes as
T4300 699-705 VBN denotes judged
T4301 706-708 IN denotes by
T4302 709-716 NN denotes absence
T4303 717-719 IN denotes of
T4304 720-730 JJ denotes persistent
T4306 731-734 NN denotes DSB
T4307 735-741 NN denotes repair
T4305 742-749 NNS denotes markers
T4308 749-750 : denotes ;
T4298 751-754 VB denotes see
T4309 755-760 RB denotes above
T4310 760-761 -RRB- denotes )
T4311 761-763 , denotes ,
T4312 763-766 CC denotes but
T4313 767-771 JJS denotes most
T4315 772-774 IN denotes of
T4316 775-778 DT denotes the
T4318 779-788 NN denotes pachytene
T4317 789-795 NNS denotes nuclei
T4314 796-799 VBD denotes had
T4319 800-804 NN denotes MLH1
T4321 804-805 HYPH denotes /
T4322 805-806 CD denotes 3
T4320 807-811 NNS denotes foci
T4323 811-813 , denotes ,
T4324 813-815 PRP denotes it
T4294 816-819 VBD denotes was
T4325 820-828 JJ denotes unlikely
T4326 829-833 IN denotes that
T4328 834-837 DT denotes the
T4330 838-842 NN denotes MLH1
T4331 842-843 HYPH denotes /
T4332 843-844 CD denotes 3
T4329 845-849 NNS denotes foci
T4327 850-856 VBD denotes formed
T4333 857-861 RB denotes only
T4334 862-864 IN denotes on
T4335 865-876 NNS denotes chromosomes
T4336 877-881 IN denotes with
T4337 882-887 RB denotes fully
T4338 888-896 VBN denotes repaired
T4339 897-901 NNS denotes DSBs
T4340 901-902 . denotes .
T4341 902-979 sentence denotes To test this directly, we conducted double staining for MLH1 and RAD51/DMC1.
T4342 903-905 TO denotes To
T4343 906-910 VB denotes test
T4345 911-915 DT denotes this
T4346 916-924 RB denotes directly
T4347 924-926 , denotes ,
T4348 926-928 PRP denotes we
T4344 929-938 VBD denotes conducted
T4349 939-945 JJ denotes double
T4350 946-954 NN denotes staining
T4351 955-958 IN denotes for
T4352 959-963 NN denotes MLH1
T4353 964-967 CC denotes and
T4354 968-973 NN denotes RAD51
T4356 973-974 HYPH denotes /
T4355 974-978 NN denotes DMC1
T4357 978-979 . denotes .
T4358 979-1082 sentence denotes MLH1 foci were present on chromosomes that also contained numerous RAD51/DMC1 foci (Figure 4O and 4P).
T4359 980-984 NN denotes MLH1
T4360 985-989 NNS denotes foci
T4361 990-994 VBD denotes were
T4362 995-1002 JJ denotes present
T4363 1003-1005 IN denotes on
T4364 1006-1017 NNS denotes chromosomes
T4365 1018-1022 WDT denotes that
T4367 1023-1027 RB denotes also
T4366 1028-1037 VBD denotes contained
T4368 1038-1046 JJ denotes numerous
T4370 1047-1052 NN denotes RAD51
T4372 1052-1053 HYPH denotes /
T4371 1053-1057 NN denotes DMC1
T4369 1058-1062 NNS denotes foci
T4373 1063-1064 -LRB- denotes (
T4375 1064-1070 NN denotes Figure
T4374 1071-1073 NN denotes 4O
T4376 1074-1077 CC denotes and
T4377 1078-1080 NN denotes 4P
T4378 1080-1081 -RRB- denotes )
T4379 1081-1082 . denotes .
R2657 T4145 T4146 det The,persistence
R2658 T4146 T4147 nsubj persistence,suggests
R2659 T4148 T4146 prep of,persistence
R2660 T4149 T4148 pobj BLM,of
R2661 T4150 T4146 prep on,persistence
R2662 T4151 T4152 compound Trip13Gt,Gt
R2663 T4152 T4154 compound Gt,spermatocyte
R2664 T4153 T4152 punct /,Gt
R2665 T4154 T4155 compound spermatocyte,chromosomes
R2666 T4155 T4150 pobj chromosomes,on
R2667 T4156 T4157 mark that,correspond
R2668 T4157 T4147 ccomp correspond,suggests
R2669 T4158 T4159 advmod at,least
R2670 T4159 T4160 advmod least,subset
R2671 T4160 T4157 nsubj subset,correspond
R2672 T4161 T4160 det a,subset
R2673 T4162 T4160 prep of,subset
R2674 T4163 T4164 det the,DSBs
R2675 T4164 T4162 pobj DSBs,of
R2676 T4165 T4164 amod unrepaired,DSBs
R2677 T4166 T4157 prep to,correspond
R2678 T4167 T4166 pobj sites,to
R2679 T4168 T4167 prep of,sites
R2680 T4169 T4170 amod defective,repair
R2681 T4170 T4168 pobj repair,of
R2682 T4171 T4172 npadvmod NCO,recombinational
R2683 T4172 T4170 amod recombinational,repair
R2684 T4173 T4147 punct .,suggests
R2685 T4175 T4176 aux To,assess
R2686 T4176 T4177 advcl assess,examined
R2687 T4178 T4179 mark whether,occurs
R2688 T4179 T4176 ccomp occurs,assess
R2689 T4180 T4181 compound CO,recombination
R2690 T4181 T4179 nsubj recombination,occurs
R2691 T4182 T4179 prep in,occurs
R2692 T4183 T4184 det the,mutant
R2693 T4184 T4182 pobj mutant,in
R2694 T4185 T4177 punct ", ",examined
R2695 T4186 T4177 nsubj we,examined
R2696 T4187 T4188 det the,distribution
R2697 T4188 T4177 dobj distribution,examined
R2698 T4189 T4188 prep of,distribution
R2699 T4190 T4191 det the,proteins
R2700 T4191 T4189 pobj proteins,of
R2701 T4192 T4193 compound mismatch,repair
R2702 T4193 T4191 compound repair,proteins
R2703 T4194 T4191 appos MLH1,proteins
R2704 T4195 T4194 cc and,MLH1
R2705 T4196 T4194 conj MLH3,MLH1
R2706 T4197 T4191 punct ", ",proteins
R2707 T4198 T4199 dep which,are
R2708 T4199 T4191 relcl are,proteins
R2709 T4200 T4199 advmod normally,are
R2710 T4201 T4199 acomp detectable,are
R2711 T4202 T4199 prep as,are
R2712 T4203 T4202 pobj foci,as
R2713 T4204 T4203 prep in,foci
R2714 T4205 T4206 amod mid,late
R2715 T4206 T4208 amod late,pachynema
R2716 T4207 T4206 punct -,late
R2717 T4208 T4204 pobj pachynema,in
R2718 T4209 T4199 cc and,are
R2719 T4210 T4199 conj mark,are
R2720 T4211 T4212 det the,locations
R2721 T4212 T4210 dobj locations,mark
R2722 T4213 T4212 prep of,locations
R2723 T4214 T4213 pobj chiasmata,of
R2724 T4215 T4216 punct [,31
R2725 T4216 T4177 parataxis 31,examined
R2726 T4217 T4216 nummod 30,31
R2727 T4218 T4216 punct ",",31
R2728 T4219 T4216 punct ],31
R2729 T4220 T4177 punct .,examined
R2730 T4222 T4223 advmod Remarkably,formed
R2731 T4223 T4230 ccomp formed,observed
R2732 T4224 T4223 punct ", ",formed
R2733 T4225 T4226 nmod MLH1,foci
R2734 T4226 T4223 nsubjpass foci,formed
R2735 T4227 T4225 punct /,MLH1
R2736 T4228 T4225 nummod 3,MLH1
R2737 T4229 T4223 auxpass were,formed
R2738 T4231 T4230 punct ;,observed
R2739 T4232 T4230 nsubj we,observed
R2740 T4233 T4234 quantmod 1,2
R2741 T4234 T4236 nummod 2,foci
R2742 T4235 T4234 punct –,2
R2743 T4236 T4230 dobj foci,observed
R2744 T4237 T4238 punct /,chromosome
R2745 T4238 T4236 prep chromosome,foci
R2746 T4239 T4230 prep as,observed
R2747 T4240 T4239 prep in,as
R2748 T4241 T4242 amod wild,type
R2749 T4242 T4240 pobj type,in
R2750 T4243 T4239 cc and,as
R2751 T4244 T4239 conj at,as
R2752 T4245 T4246 amod typical,levels
R2753 T4246 T4244 pobj levels,at
R2754 T4247 T4246 amod overall,levels
R2755 T4248 T4249 punct (,10
R2756 T4249 T4246 parataxis 10,levels
R2757 T4250 T4251 nsubj MLH3,2
R2758 T4251 T4249 ccomp 2,10
R2759 T4252 T4251 punct =,2
R2760 T4253 T4251 quantmod 23,2
R2761 T4254 T4251 punct ±,2
R2762 T4255 T4249 punct ", ",10
R2763 T4256 T4249 nsubj N,10
R2764 T4257 T4249 punct =,10
R2765 T4258 T4249 punct ;,10
R2766 T4259 T4260 punct [,32
R2767 T4260 T4249 parataxis 32,10
R2768 T4261 T4260 nummod 30,32
R2769 T4262 T4260 punct ",",32
R2770 T4263 T4260 punct ],32
R2771 T4264 T4249 punct ),10
R2772 T4265 T4230 prep on,observed
R2773 T4266 T4267 amod mid,late
R2774 T4267 T4269 nmod late,pachytene
R2775 T4268 T4267 punct -,late
R2776 T4269 T4270 compound pachytene,chromosomes
R2777 T4270 T4265 pobj chromosomes,on
R2778 T4271 T4272 punct (,4M
R2779 T4272 T4230 parataxis 4M,observed
R2780 T4273 T4272 compound Figure,4M
R2781 T4274 T4272 cc and,4M
R2782 T4275 T4272 conj 4N,4M
R2783 T4276 T4272 punct ;,4M
R2784 T4277 T4278 nsubj MLH1,shown
R2785 T4278 T4272 ccomp shown,4M
R2786 T4279 T4278 neg not,shown
R2787 T4280 T4272 punct ),4M
R2788 T4281 T4230 punct .,observed
R2789 T4283 T4284 mark Since,had
R2790 T4284 T4294 advcl had,was
R2791 T4285 T4286 punct <,1
R2792 T4286 T4287 nummod 1,%
R2793 T4287 T4284 nsubj %,had
R2794 T4288 T4287 prep of,%
R2795 T4289 T4290 compound Trip13Gt,Gt
R2796 T4290 T4292 compound Gt,pachytene
R2797 T4291 T4290 punct /,Gt
R2798 T4292 T4293 compound pachytene,nuclei
R2799 T4293 T4288 pobj nuclei,of
R2800 T4295 T4296 amod normal,repair
R2801 T4296 T4284 dobj repair,had
R2802 T4297 T4298 punct (,see
R2803 T4298 T4284 parataxis see,had
R2804 T4299 T4300 mark as,judged
R2805 T4300 T4298 advcl judged,see
R2806 T4301 T4300 prep by,judged
R2807 T4302 T4301 pobj absence,by
R2808 T4303 T4302 prep of,absence
R2809 T4304 T4305 amod persistent,markers
R2810 T4305 T4303 pobj markers,of
R2811 T4306 T4307 compound DSB,repair
R2812 T4307 T4305 compound repair,markers
R2813 T4308 T4298 punct ;,see
R2814 T4309 T4298 dobj above,see
R2815 T4310 T4298 punct ),see
R2816 T4311 T4284 punct ", ",had
R2817 T4312 T4284 cc but,had
R2818 T4313 T4314 nsubj most,had
R2819 T4314 T4284 conj had,had
R2820 T4315 T4313 prep of,most
R2821 T4316 T4317 det the,nuclei
R2822 T4317 T4315 pobj nuclei,of
R2823 T4318 T4317 compound pachytene,nuclei
R2824 T4319 T4320 nmod MLH1,foci
R2825 T4320 T4314 dobj foci,had
R2826 T4321 T4319 punct /,MLH1
R2827 T4322 T4319 nummod 3,MLH1
R2828 T4323 T4294 punct ", ",was
R2829 T4324 T4294 nsubj it,was
R2830 T4325 T4294 acomp unlikely,was
R2831 T4326 T4327 mark that,formed
R2832 T4327 T4294 ccomp formed,was
R2833 T4328 T4329 det the,foci
R2834 T4329 T4327 nsubj foci,formed
R2835 T4330 T4329 nmod MLH1,foci
R2836 T4331 T4330 punct /,MLH1
R2837 T4332 T4330 nummod 3,MLH1
R2838 T4333 T4334 advmod only,on
R2839 T4334 T4327 prep on,formed
R2840 T4335 T4334 pobj chromosomes,on
R2841 T4336 T4335 prep with,chromosomes
R2842 T4337 T4338 advmod fully,repaired
R2843 T4338 T4339 amod repaired,DSBs
R2844 T4339 T4336 pobj DSBs,with
R2845 T4340 T4294 punct .,was
R2846 T4342 T4343 aux To,test
R2847 T4343 T4344 advcl test,conducted
R2848 T4345 T4343 dobj this,test
R2849 T4346 T4343 advmod directly,test
R2850 T4347 T4344 punct ", ",conducted
R2851 T4348 T4344 nsubj we,conducted
R2852 T4349 T4350 amod double,staining
R2853 T4350 T4344 dobj staining,conducted
R2854 T4351 T4344 prep for,conducted
R2855 T4352 T4351 pobj MLH1,for
R2856 T4353 T4352 cc and,MLH1
R2857 T4354 T4355 compound RAD51,DMC1
R2858 T4355 T4352 conj DMC1,MLH1
R2859 T4356 T4355 punct /,DMC1
R2860 T4357 T4344 punct .,conducted
R2861 T4359 T4360 compound MLH1,foci
R2862 T4360 T4361 nsubj foci,were
R2863 T4362 T4361 acomp present,were
R2864 T4363 T4361 prep on,were
R2865 T4364 T4363 pobj chromosomes,on
R2866 T4365 T4366 dep that,contained
R2867 T4366 T4364 relcl contained,chromosomes
R2868 T4367 T4366 advmod also,contained
R2869 T4368 T4369 amod numerous,foci
R2870 T4369 T4366 dobj foci,contained
R2871 T4370 T4371 compound RAD51,DMC1
R2872 T4371 T4369 compound DMC1,foci
R2873 T4372 T4371 punct /,DMC1
R2874 T4373 T4374 punct (,4O
R2875 T4374 T4366 parataxis 4O,contained
R2876 T4375 T4374 compound Figure,4O
R2877 T4376 T4374 cc and,4O
R2878 T4377 T4374 conj 4P,4O
R2879 T4378 T4374 punct ),4O
R2880 T4379 T4361 punct .,were