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PMC:1914394 / 8857-9878 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T4711 0-2 PRP denotes It
T4713 3-6 VBZ denotes has
T4714 7-11 VBN denotes been
T4712 12-17 VBN denotes known
T4715 18-21 IN denotes for
T4716 22-26 JJ denotes many
T4717 27-32 NNS denotes years
T4718 33-37 IN denotes that
T4720 38-40 NN denotes Rb
T4721 41-45 NN denotes loss
T4719 46-54 VBZ denotes perturbs
T4722 55-63 JJ denotes neuronal
T4723 64-79 NN denotes differentiation
T4724 80-81 -LRB- denotes [
T4725 81-83 CD denotes 26
T4726 83-84 SYM denotes –
T4727 84-86 CD denotes 29
T4728 86-87 -RRB- denotes ]
T4729 87-88 . denotes .
T4730 88-238 sentence denotes However, prior work could not exclude the possibility that differentiation defects are simply an indirect consequence of abnormal division and death.
T4731 89-96 RB denotes However
T4733 96-98 , denotes ,
T4734 98-103 JJ denotes prior
T4735 104-108 NN denotes work
T4736 109-114 MD denotes could
T4737 115-118 RB denotes not
T4732 119-126 VB denotes exclude
T4738 127-130 DT denotes the
T4739 131-142 NN denotes possibility
T4740 143-147 IN denotes that
T4742 148-163 NN denotes differentiation
T4743 164-171 NNS denotes defects
T4741 172-175 VBP denotes are
T4744 176-182 RB denotes simply
T4745 183-185 DT denotes an
T4747 186-194 JJ denotes indirect
T4746 195-206 NN denotes consequence
T4748 207-209 IN denotes of
T4749 210-218 JJ denotes abnormal
T4750 219-227 NN denotes division
T4751 228-231 CC denotes and
T4752 232-237 NN denotes death
T4753 237-238 . denotes .
T4754 238-347 sentence denotes If Rb does regulate differentiation directly it is unclear whether it does so in all or a subset of neurons.
T4755 239-241 IN denotes If
T4757 242-244 NN denotes Rb
T4758 245-249 VBZ denotes does
T4756 250-258 VB denotes regulate
T4760 259-274 NN denotes differentiation
T4761 275-283 RB denotes directly
T4762 284-286 PRP denotes it
T4759 287-289 VBZ denotes is
T4763 290-297 JJ denotes unclear
T4764 298-305 IN denotes whether
T4766 306-308 PRP denotes it
T4765 309-313 VBZ denotes does
T4767 314-316 RB denotes so
T4768 317-319 IN denotes in
T4769 320-323 DT denotes all
T4770 324-326 CC denotes or
T4771 327-328 DT denotes a
T4772 329-335 NN denotes subset
T4774 336-338 IN denotes of
T4773 339-346 NNS denotes neurons
T4775 346-347 . denotes .
T4776 347-394 sentence denotes Moreover, the mechanism has never been solved.
T4777 348-356 RB denotes Moreover
T4779 356-358 , denotes ,
T4780 358-361 DT denotes the
T4781 362-371 NN denotes mechanism
T4782 372-375 VBZ denotes has
T4783 376-381 RB denotes never
T4784 382-386 VBN denotes been
T4778 387-393 VBN denotes solved
T4785 393-394 . denotes .
T4786 394-609 sentence denotes In other cell types where Rb may promote differentiation directly, such as muscle and bone, it seems to do so through E2f-independent means by potentiating tissue-specific transcription factors (Figure 1B) [30–33].
T4787 395-397 IN denotes In
T4789 398-403 JJ denotes other
T4791 404-408 NN denotes cell
T4790 409-414 NNS denotes types
T4792 415-420 WRB denotes where
T4794 421-423 NN denotes Rb
T4795 424-427 MD denotes may
T4793 428-435 VB denotes promote
T4796 436-451 NN denotes differentiation
T4797 452-460 RB denotes directly
T4798 460-462 , denotes ,
T4799 462-466 JJ denotes such
T4800 467-469 IN denotes as
T4801 470-476 NN denotes muscle
T4802 477-480 CC denotes and
T4803 481-485 NN denotes bone
T4804 485-487 , denotes ,
T4805 487-489 PRP denotes it
T4788 490-495 VBZ denotes seems
T4806 496-498 TO denotes to
T4807 499-501 VB denotes do
T4808 502-504 RB denotes so
T4809 505-512 IN denotes through
T4810 513-516 NN denotes E2f
T4812 516-517 HYPH denotes -
T4811 517-528 JJ denotes independent
T4813 529-534 NNS denotes means
T4814 535-537 IN denotes by
T4815 538-550 VBG denotes potentiating
T4816 551-557 NN denotes tissue
T4818 557-558 HYPH denotes -
T4817 558-566 JJ denotes specific
T4820 567-580 NN denotes transcription
T4819 581-588 NNS denotes factors
T4821 589-590 -LRB- denotes (
T4823 590-596 NN denotes Figure
T4822 597-599 NN denotes 1B
T4824 599-600 -RRB- denotes )
T4825 601-602 -LRB- denotes [
T4826 602-604 CD denotes 30
T4827 604-605 SYM denotes –
T4828 605-607 CD denotes 33
T4829 607-608 -RRB- denotes ]
T4830 608-609 . denotes .
T4831 609-778 sentence denotes In the retina, others have noted abnormally shaped Rb KO rods and have suggested Rb may directly promote their morphogenesis by activating retina-specific factors [29].
T4832 610-612 IN denotes In
T4834 613-616 DT denotes the
T4835 617-623 NN denotes retina
T4836 623-625 , denotes ,
T4837 625-631 NNS denotes others
T4838 632-636 VBP denotes have
T4833 637-642 VBN denotes noted
T4839 643-653 RB denotes abnormally
T4840 654-660 VBN denotes shaped
T4842 661-663 NN denotes Rb
T4843 664-666 NN denotes KO
T4841 667-671 NNS denotes rods
T4844 672-675 CC denotes and
T4845 676-680 VBP denotes have
T4846 681-690 VBN denotes suggested
T4847 691-693 NN denotes Rb
T4849 694-697 MD denotes may
T4850 698-706 RB denotes directly
T4848 707-714 VB denotes promote
T4851 715-720 PRP$ denotes their
T4852 721-734 NN denotes morphogenesis
T4853 735-737 IN denotes by
T4854 738-748 VBG denotes activating
T4855 749-755 NN denotes retina
T4857 755-756 HYPH denotes -
T4856 756-764 JJ denotes specific
T4858 765-772 NNS denotes factors
T4859 773-774 -LRB- denotes [
T4860 774-776 CD denotes 29
T4861 776-777 -RRB- denotes ]
T4862 777-778 . denotes .
T4863 778-909 sentence denotes However, differentiation defects in any Rb KO neuron could be an indirect effect of ectopic division and/or apoptosis (Figure 1B).
T4864 779-786 RB denotes However
T4866 786-788 , denotes ,
T4867 788-803 NN denotes differentiation
T4868 804-811 NNS denotes defects
T4869 812-814 IN denotes in
T4870 815-818 DT denotes any
T4872 819-821 NN denotes Rb
T4873 822-824 NN denotes KO
T4871 825-831 NN denotes neuron
T4874 832-837 MD denotes could
T4865 838-840 VB denotes be
T4875 841-843 DT denotes an
T4877 844-852 JJ denotes indirect
T4876 853-859 NN denotes effect
T4878 860-862 IN denotes of
T4879 863-870 JJ denotes ectopic
T4880 871-879 NN denotes division
T4881 880-883 CC denotes and
T4882 883-884 HYPH denotes /
T4883 884-886 CC denotes or
T4884 887-896 NN denotes apoptosis
T4885 897-898 -LRB- denotes (
T4887 898-904 NN denotes Figure
T4886 905-907 NN denotes 1B
T4888 907-908 -RRB- denotes )
T4889 908-909 . denotes .
T4890 909-1021 sentence denotes Thus, it is critical to study differentiation of Rb KO cells in the absence of ectopic proliferation and death.
T4891 910-914 RB denotes Thus
T4893 914-916 , denotes ,
T4894 916-918 PRP denotes it
T4892 919-921 VBZ denotes is
T4895 922-930 JJ denotes critical
T4896 931-933 TO denotes to
T4897 934-939 VB denotes study
T4898 940-955 NN denotes differentiation
T4899 956-958 IN denotes of
T4900 959-961 NN denotes Rb
T4901 962-964 NN denotes KO
T4902 965-970 NNS denotes cells
T4903 971-973 IN denotes in
T4904 974-977 DT denotes the
T4905 978-985 NN denotes absence
T4906 986-988 IN denotes of
T4907 989-996 JJ denotes ectopic
T4908 997-1010 NN denotes proliferation
T4909 1011-1014 CC denotes and
T4910 1015-1020 NN denotes death
T4911 1020-1021 . denotes .
R1000 T4720 T4721 compound Rb,loss
R1001 T4721 T4719 nsubj loss,perturbs
R1002 T4722 T4723 amod neuronal,differentiation
R1004 T4723 T4719 dobj differentiation,perturbs
R1005 T4724 T4725 punct [,26
R1006 T4725 T4712 parataxis 26,known
R1008 T4726 T4727 punct –,29
R1009 T4727 T4725 prep 29,26
R1010 T4728 T4725 punct ],26
R1012 T4729 T4712 punct .,known
R1013 T4731 T4732 advmod However,exclude
R1015 T4733 T4732 punct ", ",exclude
R1016 T4734 T4735 amod prior,work
R1018 T4735 T4732 nsubj work,exclude
R1019 T4736 T4732 aux could,exclude
R1020 T4737 T4732 neg not,exclude
R1022 T4738 T4739 det the,possibility
R1023 T4739 T4732 dobj possibility,exclude
R1024 T4740 T4741 mark that,are
R1026 T4741 T4739 acl are,possibility
R1027 T4742 T4743 compound differentiation,defects
R1029 T4743 T4741 nsubj defects,are
R1030 T4744 T4741 advmod simply,are
R1031 T4745 T4746 det an,consequence
R1033 T4746 T4741 attr consequence,are
R1034 T4747 T4746 amod indirect,consequence
R1035 T4748 T4746 prep of,consequence
R1037 T4749 T4750 amod abnormal,division
R1038 T4750 T4748 pobj division,of
R1039 T4751 T4750 cc and,division
R1041 T4752 T4750 conj death,division
R1042 T4753 T4732 punct .,exclude
R1044 T4755 T4756 mark If,regulate
R1045 T4756 T4759 advcl regulate,is
R1046 T4757 T4756 nsubj Rb,regulate
R1048 T4758 T4756 aux does,regulate
R1049 T4760 T4756 dobj differentiation,regulate
R1050 T4761 T4756 advmod directly,regulate
R1051 T4762 T4759 nsubj it,is
R1052 T4763 T4759 acomp unclear,is
R1054 T4764 T4765 mark whether,does
R1055 T4765 T4759 ccomp does,is
R1056 T4766 T4765 nsubj it,does
R1058 T4767 T4765 advmod so,does
R1059 T4768 T4765 prep in,does
R1060 T4769 T4768 pobj all,in
R1062 T4770 T4769 cc or,all
R1063 T4771 T4772 det a,subset
R1064 T4772 T4773 nmod subset,neurons
R1066 T4773 T4769 conj neurons,all
R1067 T4774 T4772 prep of,subset
R1069 T4775 T4759 punct .,is
R1070 T4777 T4778 advmod Moreover,solved
R1072 T4779 T4778 punct ", ",solved
R1073 T4780 T4781 det the,mechanism
R1075 T4781 T4778 nsubjpass mechanism,solved
R1076 T4782 T4778 aux has,solved
R1077 T4783 T4778 neg never,solved
R1079 T4784 T4778 auxpass been,solved
R1080 T4785 T4778 punct .,solved
R1082 T4787 T4788 prep In,seems
R1083 T4789 T4790 amod other,types
R1085 T4790 T4787 pobj types,In
R1086 T4791 T4790 compound cell,types
R1087 T4792 T4793 advmod where,promote
R1092 T4793 T4790 relcl promote,types
R1093 T4794 T4793 nsubj Rb,promote
R1094 T4795 T4793 aux may,promote
R1096 T4796 T4793 dobj differentiation,promote
R1097 T4797 T4793 advmod directly,promote
R1099 T4798 T4790 punct ", ",types
R1100 T4799 T4800 amod such,as
R1101 T4800 T4790 prep as,types
R1102 T4801 T4800 pobj muscle,as
R1103 T4802 T4801 cc and,muscle
R1105 T4803 T4801 conj bone,muscle
R1106 T4804 T4788 punct ", ",seems
R1107 T4805 T4788 nsubj it,seems
R1108 T4806 T4807 aux to,do
R1109 T4807 T4788 xcomp do,seems
R1111 T4808 T4807 advmod so,do
R1112 T4809 T4807 prep through,do
R1113 T4810 T4811 npadvmod E2f,independent
R1114 T4811 T4813 amod independent,means
R1116 T4812 T4811 punct -,independent
R1117 T4813 T4809 pobj means,through
R1118 T4814 T4807 prep by,do
R1120 T4815 T4814 pcomp potentiating,by
R1121 T4816 T4817 npadvmod tissue,specific
R1122 T4817 T4819 amod specific,factors
R1124 T4818 T4817 punct -,specific
R1125 T4819 T4815 dobj factors,potentiating
R1126 T4820 T4819 compound transcription,factors
R1128 T4821 T4822 punct (,1B
R1129 T4822 T4807 parataxis 1B,do
R1130 T4823 T4822 compound Figure,1B
R1132 T4824 T4822 punct ),1B
R1133 T4825 T4826 punct [,30
R1134 T4826 T4807 parataxis 30,do
R1136 T4827 T4828 punct –,33
R1137 T4828 T4826 prep 33,30
R1138 T4829 T4826 punct ],30
R1140 T4830 T4788 punct .,seems
R1141 T4832 T4833 prep In,noted
R1143 T4834 T4835 det the,retina
R1144 T4835 T4832 pobj retina,In
R1146 T4836 T4833 punct ", ",noted
R1147 T4837 T4833 nsubj others,noted
R1148 T4838 T4833 aux have,noted
R1150 T4839 T4840 advmod abnormally,shaped
R1151 T4840 T4841 amod shaped,rods
R1152 T4841 T4833 dobj rods,noted
R1153 T4842 T4843 compound Rb,KO
R1154 T4843 T4841 compound KO,rods
R1155 T4844 T4833 cc and,noted
R1156 T4845 T4846 aux have,suggested
R1158 T4846 T4833 conj suggested,noted
R1159 T4847 T4848 nsubj Rb,promote
R1160 T4848 T4846 advcl promote,suggested
R1161 T4849 T4848 aux may,promote
R1163 T4850 T4848 advmod directly,promote
R1164 T4851 T4852 poss their,morphogenesis
R1166 T4852 T4848 dobj morphogenesis,promote
R1167 T4853 T4848 prep by,promote
R1168 T4854 T4853 pcomp activating,by
R1169 T4855 T4856 npadvmod retina,specific
R1171 T4856 T4858 amod specific,factors
R1172 T4857 T4856 punct -,specific
R1173 T4858 T4854 dobj factors,activating
R1175 T4859 T4860 punct [,29
R1176 T4860 T4848 parataxis 29,promote
R1177 T4861 T4860 punct ],29
R1179 T4862 T4833 punct .,noted
R1181 T4864 T4865 advmod However,be
R1183 T4866 T4865 punct ", ",be
R1184 T4867 T4868 compound differentiation,defects
R1185 T4868 T4865 nsubj defects,be
R1187 T4869 T4868 prep in,defects
R1188 T4870 T4871 det any,neuron
R1189 T4871 T4869 pobj neuron,in
R1190 T4898 T4897 dobj differentiation,study
R1191 T4872 T4873 compound Rb,KO
R1192 T4873 T4871 compound KO,neuron
R1193 T4874 T4865 aux could,be
R1194 T4875 T4876 det an,effect
R1195 T4876 T4865 attr effect,be
R1196 T4899 T4898 prep of,differentiation
R1197 T4877 T4876 amod indirect,effect
R1198 T4878 T4876 prep of,effect
R1199 T4900 T4901 compound Rb,KO
R1200 T4901 T4902 compound KO,cells
R1201 T4879 T4880 amod ectopic,division
R1202 T4880 T4878 pobj division,of
R1203 T4881 T4880 cc and,division
R1204 T4902 T4899 pobj cells,of
R1205 T4882 T4881 punct /,and
R1206 T4883 T4881 cc or,and
R1207 T4884 T4880 conj apoptosis,division
R1208 T4885 T4886 punct (,1B
R1209 T4886 T4865 parataxis 1B,be
R1210 T4887 T4886 compound Figure,1B
R1211 T4903 T4897 prep in,study
R1212 T4888 T4886 punct ),1B
R1213 T4889 T4865 punct .,be
R1214 T4904 T4905 det the,absence
R1215 T4891 T4892 advmod Thus,is
R1216 T4893 T4892 punct ", ",is
R1217 T4905 T4903 pobj absence,in
R1218 T4894 T4892 nsubj it,is
R1219 T4895 T4892 acomp critical,is
R1220 T4906 T4905 prep of,absence
R1221 T4896 T4897 aux to,study
R1222 T4897 T4892 xcomp study,is
R1223 T4907 T4908 amod ectopic,proliferation
R1224 T4908 T4906 pobj proliferation,of
R1226 T4909 T4908 cc and,proliferation
R1230 T4910 T4908 conj death,proliferation
R1234 T4911 T4892 punct .,is
R990 T4711 T4712 nsubjpass It,known
R992 T4713 T4712 aux has,known
R993 T4714 T4712 auxpass been,known
R995 T4715 T4712 prep for,known
R996 T4716 T4717 amod many,years
R997 T4717 T4715 pobj years,for
R998 T4718 T4719 mark that,perturbs
R999 T4719 T4712 ccomp perturbs,known