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PMC:1914394 / 7893-8625 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T4508 0-3 NN denotes E2f
T4510 4-10 NN denotes family
T4509 11-20 NN denotes diversity
T4512 21-23 VBZ denotes is
T4511 24-32 VBN denotes expanded
T4513 33-35 IN denotes by
T4514 36-40 NN denotes E2f3
T4515 41-49 NNS denotes isoforms
T4516 49-50 . denotes .
T4517 50-158 sentence denotes Alternative promoters generate two forms (a and b) that are identical except for distinct first exons [16].
T4518 51-62 JJ denotes Alternative
T4519 63-72 NNS denotes promoters
T4520 73-81 VBP denotes generate
T4521 82-85 CD denotes two
T4522 86-91 NNS denotes forms
T4523 92-93 -LRB- denotes (
T4524 93-94 NN denotes a
T4525 95-98 CC denotes and
T4526 99-100 NN denotes b
T4527 100-101 -RRB- denotes )
T4528 102-106 WDT denotes that
T4529 107-110 VBP denotes are
T4530 111-120 JJ denotes identical
T4531 121-127 IN denotes except
T4532 128-131 IN denotes for
T4533 132-140 JJ denotes distinct
T4535 141-146 JJ denotes first
T4534 147-152 NNS denotes exons
T4536 153-154 -LRB- denotes [
T4537 154-156 CD denotes 16
T4538 156-157 -RRB- denotes ]
T4539 157-158 . denotes .
T4540 158-298 sentence denotes E2f3a is a strong activator, and, like other activating E2fs, its expression is induced when quiescent cells are stimulated to divide [16].
T4541 159-164 NN denotes E2f3a
T4542 165-167 VBZ denotes is
T4543 168-169 DT denotes a
T4545 170-176 JJ denotes strong
T4544 177-186 NN denotes activator
T4546 186-188 , denotes ,
T4547 188-191 CC denotes and
T4548 191-193 , denotes ,
T4549 193-197 IN denotes like
T4551 198-203 JJ denotes other
T4553 204-214 VBG denotes activating
T4552 215-219 NNS denotes E2fs
T4554 219-221 , denotes ,
T4555 221-224 PRP$ denotes its
T4556 225-235 NN denotes expression
T4557 236-238 VBZ denotes is
T4550 239-246 VBN denotes induced
T4558 247-251 WRB denotes when
T4560 252-261 JJ denotes quiescent
T4561 262-267 NNS denotes cells
T4562 268-271 VBP denotes are
T4559 272-282 VBN denotes stimulated
T4563 283-285 TO denotes to
T4564 286-292 VB denotes divide
T4565 293-294 -LRB- denotes [
T4566 294-296 CD denotes 16
T4567 296-297 -RRB- denotes ]
T4568 297-298 . denotes .
T4569 298-486 sentence denotes E2f3b, like repressive E2fs, is present in both quiescent and dividing cells, and in quiescent fibroblasts it associates primarily with Rb, suggesting that it mediates repression [16–18].
T4570 299-304 NN denotes E2f3b
T4572 304-306 , denotes ,
T4573 306-310 IN denotes like
T4574 311-321 JJ denotes repressive
T4575 322-326 NNS denotes E2fs
T4576 326-328 , denotes ,
T4571 328-330 VBZ denotes is
T4577 331-338 JJ denotes present
T4578 339-341 IN denotes in
T4579 342-346 CC denotes both
T4580 347-356 JJ denotes quiescent
T4582 357-360 CC denotes and
T4583 361-369 VBG denotes dividing
T4581 370-375 NNS denotes cells
T4584 375-377 , denotes ,
T4585 377-380 CC denotes and
T4586 381-383 IN denotes in
T4588 384-393 JJ denotes quiescent
T4589 394-405 NNS denotes fibroblasts
T4590 406-408 PRP denotes it
T4587 409-419 VBZ denotes associates
T4591 420-429 RB denotes primarily
T4592 430-434 IN denotes with
T4593 435-437 NN denotes Rb
T4594 437-439 , denotes ,
T4595 439-449 VBG denotes suggesting
T4596 450-454 IN denotes that
T4598 455-457 PRP denotes it
T4597 458-466 VBZ denotes mediates
T4599 467-477 NN denotes repression
T4600 478-479 -LRB- denotes [
T4601 479-481 CD denotes 16
T4602 481-482 SYM denotes –
T4603 482-484 CD denotes 18
T4604 484-485 -RRB- denotes ]
T4605 485-486 . denotes .
T4606 486-572 sentence denotes Indeed, silencing the Cdkn2d (p19Arf) locus in unstressed cells relies on E2f3b [19].
T4607 487-493 RB denotes Indeed
T4609 493-495 , denotes ,
T4610 495-504 VBG denotes silencing
T4611 505-508 DT denotes the
T4613 509-515 NN denotes Cdkn2d
T4614 516-517 -LRB- denotes (
T4615 517-523 NN denotes p19Arf
T4616 523-524 -RRB- denotes )
T4612 525-530 NN denotes locus
T4617 531-533 IN denotes in
T4618 534-544 JJ denotes unstressed
T4619 545-550 NNS denotes cells
T4608 551-557 VBZ denotes relies
T4620 558-560 IN denotes on
T4621 561-566 NN denotes E2f3b
T4622 567-568 -LRB- denotes [
T4623 568-570 CD denotes 19
T4624 570-571 -RRB- denotes ]
T4625 571-572 . denotes .
T4626 572-685 sentence denotes Other E2fs may also exist in isoforms since at least two mRNA species have been detected for E2f1 and E2f2 [16].
T4627 573-578 JJ denotes Other
T4628 579-583 NNS denotes E2fs
T4630 584-587 MD denotes may
T4631 588-592 RB denotes also
T4629 593-598 VB denotes exist
T4632 599-601 IN denotes in
T4633 602-610 NNS denotes isoforms
T4634 611-616 IN denotes since
T4636 617-619 RB denotes at
T4638 620-625 RBS denotes least
T4637 626-629 CD denotes two
T4639 630-634 NN denotes mRNA
T4640 635-642 NNS denotes species
T4641 643-647 VBP denotes have
T4642 648-652 VBN denotes been
T4635 653-661 VBN denotes detected
T4643 662-665 IN denotes for
T4644 666-670 NN denotes E2f1
T4645 671-674 CC denotes and
T4646 675-679 NN denotes E2f2
T4647 680-681 -LRB- denotes [
T4648 681-683 CD denotes 16
T4649 683-684 -RRB- denotes ]
T4650 684-685 . denotes .
T4651 685-732 sentence denotes The roles of E2f isoforms in vivo are unknown.
T4652 686-689 DT denotes The
T4653 690-695 NNS denotes roles
T4655 696-698 IN denotes of
T4656 699-702 NN denotes E2f
T4657 703-711 NNS denotes isoforms
T4658 712-714 FW denotes in
T4659 715-719 FW denotes vivo
T4654 720-723 VBP denotes are
T4660 724-731 JJ denotes unknown
T4661 731-732 . denotes .
R1003 T4631 T4629 advmod also,exist
R1007 T4632 T4629 prep in,exist
R1011 T4633 T4632 pobj isoforms,in
R1014 T4634 T4635 mark since,detected
R1017 T4635 T4629 advcl detected,exist
R1021 T4636 T4637 advmod at,two
R1025 T4637 T4639 nummod two,mRNA
R1028 T4638 T4637 advmod least,two
R1032 T4639 T4640 compound mRNA,species
R1036 T4640 T4635 nsubjpass species,detected
R1040 T4641 T4635 aux have,detected
R1043 T4642 T4635 auxpass been,detected
R1047 T4643 T4635 prep for,detected
R1053 T4644 T4643 pobj E2f1,for
R1057 T4645 T4644 cc and,E2f1
R1061 T4646 T4644 conj E2f2,E2f1
R1065 T4647 T4648 punct [,16
R1068 T4648 T4635 parataxis 16,detected
R1071 T4649 T4648 punct ],16
R1074 T4650 T4629 punct .,exist
R1078 T4652 T4653 det The,roles
R1081 T4653 T4654 nsubj roles,are
R1084 T4655 T4653 prep of,roles
R1088 T4656 T4657 compound E2f,isoforms
R1089 T4657 T4655 pobj isoforms,of
R1090 T4658 T4659 advmod in,vivo
R1091 T4659 T4653 advmod vivo,roles
R1095 T4660 T4654 acomp unknown,are
R1098 T4661 T4654 punct .,are
R849 T4582 T4580 cc and,quiescent
R855 T4583 T4580 conj dividing,quiescent
R859 T4584 T4571 punct ", ",is
R862 T4585 T4571 cc and,is
R863 T4508 T4509 compound E2f,diversity
R864 T4509 T4511 nsubjpass diversity,expanded
R865 T4586 T4587 prep in,associates
R866 T4510 T4509 compound family,diversity
R867 T4512 T4511 auxpass is,expanded
R868 T4587 T4571 conj associates,is
R869 T4513 T4511 agent by,expanded
R870 T4514 T4515 compound E2f3,isoforms
R871 T4515 T4513 pobj isoforms,by
R872 T4516 T4511 punct .,expanded
R873 T4588 T4589 amod quiescent,fibroblasts
R874 T4518 T4519 amod Alternative,promoters
R875 T4589 T4586 pobj fibroblasts,in
R876 T4519 T4520 nsubj promoters,generate
R877 T4521 T4522 nummod two,forms
R878 T4590 T4587 nsubj it,associates
R879 T4522 T4520 dobj forms,generate
R880 T4523 T4522 punct (,forms
R881 T4524 T4522 appos a,forms
R882 T4591 T4592 advmod primarily,with
R883 T4592 T4587 prep with,associates
R884 T4525 T4524 cc and,a
R885 T4526 T4524 conj b,a
R886 T4593 T4592 pobj Rb,with
R887 T4527 T4522 punct ),forms
R888 T4528 T4529 dep that,are
R889 T4594 T4587 punct ", ",associates
R890 T4529 T4522 relcl are,forms
R891 T4530 T4529 acomp identical,are
R892 T4531 T4529 prep except,are
R893 T4595 T4587 advcl suggesting,associates
R894 T4532 T4531 prep for,except
R895 T4533 T4534 amod distinct,exons
R896 T4534 T4532 pobj exons,for
R897 T4535 T4534 amod first,exons
R898 T4536 T4537 punct [,16
R899 T4596 T4597 mark that,mediates
R900 T4537 T4520 parataxis 16,generate
R901 T4538 T4537 punct ],16
R902 T4597 T4595 ccomp mediates,suggesting
R903 T4539 T4520 punct .,generate
R904 T4541 T4542 nsubj E2f3a,is
R905 T4598 T4597 nsubj it,mediates
R906 T4543 T4544 det a,activator
R907 T4544 T4542 attr activator,is
R908 T4599 T4597 dobj repression,mediates
R909 T4545 T4544 amod strong,activator
R910 T4546 T4542 punct ", ",is
R911 T4547 T4542 cc and,is
R912 T4548 T4542 punct ", ",is
R913 T4600 T4601 punct [,16
R914 T4549 T4550 prep like,induced
R915 T4550 T4542 conj induced,is
R916 T4601 T4587 parataxis 16,associates
R917 T4551 T4552 amod other,E2fs
R918 T4602 T4603 punct –,18
R919 T4552 T4549 pobj E2fs,like
R920 T4553 T4552 amod activating,E2fs
R921 T4554 T4550 punct ", ",induced
R922 T4603 T4601 prep 18,16
R923 T4555 T4556 poss its,expression
R924 T4556 T4550 nsubjpass expression,induced
R925 T4557 T4550 auxpass is,induced
R926 T4604 T4601 punct ],16
R927 T4558 T4559 advmod when,stimulated
R928 T4559 T4550 advcl stimulated,induced
R929 T4560 T4561 amod quiescent,cells
R930 T4561 T4559 nsubjpass cells,stimulated
R931 T4605 T4587 punct .,associates
R932 T4562 T4559 auxpass are,stimulated
R933 T4563 T4564 aux to,divide
R934 T4564 T4559 xcomp divide,stimulated
R935 T4607 T4608 advmod Indeed,relies
R936 T4565 T4566 punct [,16
R937 T4566 T4559 parataxis 16,stimulated
R938 T4567 T4566 punct ],16
R939 T4568 T4550 punct .,induced
R940 T4609 T4608 punct ", ",relies
R941 T4570 T4571 nsubj E2f3b,is
R942 T4572 T4570 punct ", ",E2f3b
R943 T4610 T4608 csubj silencing,relies
R944 T4573 T4570 prep like,E2f3b
R945 T4574 T4575 amod repressive,E2fs
R946 T4575 T4573 pobj E2fs,like
R947 T4576 T4571 punct ", ",is
R948 T4577 T4571 acomp present,is
R949 T4578 T4571 prep in,is
R950 T4579 T4580 preconj both,quiescent
R951 T4611 T4612 det the,locus
R952 T4580 T4581 amod quiescent,cells
R953 T4581 T4578 pobj cells,in
R954 T4612 T4610 dobj locus,silencing
R955 T4613 T4612 nmod Cdkn2d,locus
R956 T4614 T4613 punct (,Cdkn2d
R957 T4615 T4613 appos p19Arf,Cdkn2d
R958 T4616 T4612 punct ),locus
R960 T4617 T4610 prep in,silencing
R964 T4618 T4619 amod unstressed,cells
R967 T4619 T4617 pobj cells,in
R971 T4620 T4608 prep on,relies
R974 T4621 T4620 pobj E2f3b,on
R977 T4622 T4623 punct [,19
R979 T4623 T4608 parataxis 19,relies
R981 T4624 T4623 punct ],19
R985 T4625 T4608 punct .,relies
R989 T4627 T4628 amod Other,E2fs
R991 T4628 T4629 nsubj E2fs,exist
R994 T4630 T4629 aux may,exist