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PMC:1914394 / 5895-7065 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T4076 0-1 NNS denotes T
T4075 0-4 sentence denotes The
T4077 1-3 DT denotes he
T4079 4-6 EX denotes re
T4078 4-19 sentence denotes retinoblastoma
T4080 6-8 VBN denotes ti
T4081 8-9 CC denotes n
T4082 9-10 NNS denotes o
T4084 10-13 JJ denotes bla
T4083 13-14 NNS denotes s
T4085 14-15 DT denotes t
T4086 15-16 NN denotes o
T4087 16-18 JJ denotes ma
T4088 19-20 sentence denotes p
T4089 19-20 NN denotes p
T4091 20-21 VB denotes r
T4090 20-27 sentence denotes rotein
T4092 21-23 NN denotes ot
T4093 23-26 VBG denotes ein
T4094 27-28 sentence denotes (
T4095 27-28 -LRB- denotes (
T4096 28-29 sentence denotes R
T4097 28-29 JJ denotes R
T4099 29-30 NNS denotes b
T4098 29-31 sentence denotes b)
T4100 30-31 -RRB- denotes )
T4101 31-101 sentence denotes is critical for cell cycle exit during retinal transition cell birth.
T4102 32-34 NN denotes is
T4103 35-43 JJ denotes critical
T4104 44-47 IN denotes for
T4105 48-52 NN denotes cell
T4106 53-58 NN denotes cycle
T4107 59-63 NN denotes exit
T4108 64-70 IN denotes during
T4109 71-78 JJ denotes retinal
T4111 79-89 NN denotes transition
T4110 90-94 NN denotes cell
T4112 95-100 NN denotes birth
T4113 100-101 . denotes .
T4114 101-231 sentence denotes Rb knockout (KO) RTCs continue to proliferate inappropriately and some (rod, ganglion, and bipolar cells) die by apoptosis [2,3].
T4115 102-104 NN denotes Rb
T4116 105-113 NN denotes knockout
T4118 114-115 -LRB- denotes (
T4119 115-117 NN denotes KO
T4120 117-118 -RRB- denotes )
T4117 119-123 NNS denotes RTCs
T4121 124-132 VBP denotes continue
T4122 133-135 TO denotes to
T4123 136-147 VB denotes proliferate
T4124 148-163 RB denotes inappropriately
T4125 164-167 CC denotes and
T4126 168-172 DT denotes some
T4128 173-174 -LRB- denotes (
T4129 174-177 NN denotes rod
T4131 177-179 , denotes ,
T4132 179-187 NN denotes ganglion
T4133 187-189 , denotes ,
T4134 189-192 CC denotes and
T4135 193-200 JJ denotes bipolar
T4130 201-206 NNS denotes cells
T4136 206-207 -RRB- denotes )
T4127 208-211 VBP denotes die
T4137 212-214 IN denotes by
T4138 215-224 NN denotes apoptosis
T4139 225-226 -LRB- denotes [
T4141 226-227 CD denotes 2
T4142 227-228 , denotes ,
T4140 228-229 CD denotes 3
T4143 229-230 -RRB- denotes ]
T4144 230-231 . denotes .
T4145 231-480 sentence denotes Rb controls the cell cycle by binding and inhibiting E2f transcription factors (E2fs) (Figure 1B), first defined as transcription factors that bind adenoviral E2 regulatory elements and subsequently shown to be critical cell cycle regulators [4,5].
T4146 232-234 NN denotes Rb
T4147 235-243 VBZ denotes controls
T4148 244-247 DT denotes the
T4150 248-252 NN denotes cell
T4149 253-258 NN denotes cycle
T4151 259-261 IN denotes by
T4152 262-269 VBG denotes binding
T4153 270-273 CC denotes and
T4154 274-284 VBG denotes inhibiting
T4155 285-288 NN denotes E2f
T4157 289-302 NN denotes transcription
T4156 303-310 NNS denotes factors
T4158 311-312 -LRB- denotes (
T4159 312-316 NNS denotes E2fs
T4160 316-317 -RRB- denotes )
T4161 318-319 -LRB- denotes (
T4163 319-325 NN denotes Figure
T4162 326-328 NN denotes 1B
T4164 328-329 -RRB- denotes )
T4165 329-331 , denotes ,
T4166 331-336 RB denotes first
T4167 337-344 VBN denotes defined
T4168 345-347 IN denotes as
T4169 348-361 NN denotes transcription
T4170 362-369 NNS denotes factors
T4171 370-374 WDT denotes that
T4172 375-379 VBP denotes bind
T4173 380-390 JJ denotes adenoviral
T4175 391-393 NN denotes E2
T4176 394-404 JJ denotes regulatory
T4174 405-413 NNS denotes elements
T4177 414-417 CC denotes and
T4178 418-430 RB denotes subsequently
T4179 431-436 VBN denotes shown
T4180 437-439 TO denotes to
T4181 440-442 VB denotes be
T4182 443-451 JJ denotes critical
T4184 452-456 NN denotes cell
T4185 457-462 NN denotes cycle
T4183 463-473 NNS denotes regulators
T4186 474-475 -LRB- denotes [
T4188 475-476 CD denotes 4
T4189 476-477 , denotes ,
T4187 477-478 CD denotes 5
T4190 478-479 -RRB- denotes ]
T4191 479-480 . denotes .
T4192 480-555 sentence denotes E2fs bind to DNA as heterodimers with proteins of the related Tfdp family.
T4193 481-485 NNS denotes E2fs
T4194 486-490 VBP denotes bind
T4195 491-493 IN denotes to
T4196 494-497 NN denotes DNA
T4197 498-500 IN denotes as
T4198 501-513 NNS denotes heterodimers
T4199 514-518 IN denotes with
T4200 519-527 NN denotes proteins
T4201 528-530 IN denotes of
T4202 531-534 DT denotes the
T4204 535-542 VBN denotes related
T4205 543-547 NN denotes Tfdp
T4203 548-554 NN denotes family
T4206 554-555 . denotes .
T4207 555-642 sentence denotes E2f1, E2f2, and E2f3a are “activating E2fs” that are required for fibroblast division.
T4208 556-560 NN denotes E2f1
T4210 560-562 , denotes ,
T4211 562-566 NN denotes E2f2
T4212 566-568 , denotes ,
T4213 568-571 CC denotes and
T4214 572-577 NN denotes E2f3a
T4209 578-581 VBP denotes are
T4215 582-583 `` denotes “
T4216 583-593 NN denotes activating
T4217 594-598 NNS denotes E2fs
T4218 598-599 '' denotes ”
T4219 600-604 WDT denotes that
T4221 605-608 VBP denotes are
T4220 609-617 VBN denotes required
T4222 618-621 IN denotes for
T4223 622-632 NN denotes fibroblast
T4224 633-641 NN denotes division
T4225 641-642 . denotes .
T4226 642-769 sentence denotes They are strong transcriptional activators that can drive G0 fibroblasts into cycle, and are inhibited when bound to Rb [4,5].
T4227 643-647 PRP denotes They
T4228 648-651 VBP denotes are
T4229 652-658 JJ denotes strong
T4231 659-674 JJ denotes transcriptional
T4230 675-685 NNS denotes activators
T4232 686-690 WDT denotes that
T4234 691-694 MD denotes can
T4233 695-700 VB denotes drive
T4235 701-703 NN denotes G0
T4236 704-715 NNS denotes fibroblasts
T4237 716-720 IN denotes into
T4238 721-726 NN denotes cycle
T4239 726-728 , denotes ,
T4240 728-731 CC denotes and
T4241 732-735 VBP denotes are
T4242 736-745 VBN denotes inhibited
T4243 746-750 WRB denotes when
T4244 751-756 VBN denotes bound
T4245 757-759 IN denotes to
T4246 760-762 NN denotes Rb
T4247 763-764 -LRB- denotes [
T4249 764-765 CD denotes 4
T4250 765-766 , denotes ,
T4248 766-767 CD denotes 5
T4251 767-768 -RRB- denotes ]
T4252 768-769 . denotes .
T4253 769-962 sentence denotes Ectopic division in Rb KO embryos can be rescued to various extents in different tissues by knocking out E2f1, E2f2, or E2f3 [6–9], but which member(s) drive division in Rb KO RTCs is unknown.
T4254 770-777 JJ denotes Ectopic
T4255 778-786 NN denotes division
T4257 787-789 IN denotes in
T4258 790-792 NN denotes Rb
T4259 793-795 NN denotes KO
T4260 796-803 NNS denotes embryos
T4261 804-807 MD denotes can
T4262 808-810 VB denotes be
T4256 811-818 VBN denotes rescued
T4263 819-821 IN denotes to
T4264 822-829 JJ denotes various
T4265 830-837 NNS denotes extents
T4266 838-840 IN denotes in
T4267 841-850 JJ denotes different
T4268 851-858 NNS denotes tissues
T4269 859-861 IN denotes by
T4270 862-870 VBG denotes knocking
T4271 871-874 RP denotes out
T4272 875-879 NN denotes E2f1
T4273 879-881 , denotes ,
T4274 881-885 NN denotes E2f2
T4275 885-887 , denotes ,
T4276 887-889 CC denotes or
T4277 890-894 NN denotes E2f3
T4278 895-896 -LRB- denotes [
T4279 896-897 CD denotes 6
T4280 897-898 SYM denotes –
T4281 898-899 CD denotes 9
T4282 899-900 -RRB- denotes ]
T4283 900-902 , denotes ,
T4284 902-905 CC denotes but
T4285 906-911 WDT denotes which
T4286 912-918 NN denotes member
T4288 918-919 -LRB- denotes (
T4289 919-920 AFX denotes s
T4290 920-921 -RRB- denotes )
T4287 922-927 VBP denotes drive
T4292 928-936 NN denotes division
T4293 937-939 IN denotes in
T4294 940-942 NN denotes Rb
T4295 943-945 NN denotes KO
T4296 946-950 NNS denotes RTCs
T4291 951-953 VBZ denotes is
T4297 954-961 JJ denotes unknown
T4298 961-962 . denotes .
T4299 962-1170 sentence denotes Other members of the family, such as E2f4 and E2f5, are known as “repressive E2fs” because they are weak activators and appear to be primarily involved in gene silencing in quiescent or differentiated cells.
T4300 963-968 JJ denotes Other
T4301 969-976 NNS denotes members
T4303 977-979 IN denotes of
T4304 980-983 DT denotes the
T4305 984-990 NN denotes family
T4306 990-992 , denotes ,
T4307 992-996 JJ denotes such
T4308 997-999 IN denotes as
T4309 1000-1004 NN denotes E2f4
T4310 1005-1008 CC denotes and
T4311 1009-1013 NN denotes E2f5
T4312 1013-1015 , denotes ,
T4313 1015-1018 VBP denotes are
T4302 1019-1024 VBN denotes known
T4314 1025-1027 IN denotes as
T4315 1028-1029 `` denotes “
T4317 1029-1039 JJ denotes repressive
T4316 1040-1044 NNS denotes E2fs
T4318 1044-1045 '' denotes ”
T4319 1046-1053 IN denotes because
T4321 1054-1058 PRP denotes they
T4320 1059-1062 VBP denotes are
T4322 1063-1067 JJ denotes weak
T4323 1068-1078 NNS denotes activators
T4324 1079-1082 CC denotes and
T4325 1083-1089 VBP denotes appear
T4326 1090-1092 TO denotes to
T4328 1093-1095 VB denotes be
T4329 1096-1105 RB denotes primarily
T4327 1106-1114 VBN denotes involved
T4330 1115-1117 IN denotes in
T4331 1118-1122 NN denotes gene
T4332 1123-1132 NN denotes silencing
T4333 1133-1135 IN denotes in
T4334 1136-1145 JJ denotes quiescent
T4336 1146-1148 CC denotes or
T4337 1149-1163 VBN denotes differentiated
T4335 1164-1169 NNS denotes cells
T4338 1169-1170 . denotes .
R463 T4086 T4083 conj o,s
R483 T4104 T4103 prep for,critical
R484 T4105 T4106 compound cell,cycle
R486 T4106 T4107 compound cycle,exit
R487 T4107 T4104 pobj exit,for
R489 T4109 T4110 amod retinal,cell
R490 T4110 T4112 compound cell,birth
R491 T4111 T4110 compound transition,cell
R493 T4112 T4108 pobj birth,during
R494 T4159 T4156 appos E2fs,factors
R495 T4115 T4116 nmod Rb,knockout
R496 T4116 T4117 nmod knockout,RTCs
R497 T4117 T4121 nsubj RTCs,continue
R498 T4118 T4116 punct (,knockout
R499 T4160 T4156 punct ),factors
R500 T4119 T4116 appos KO,knockout
R501 T4120 T4117 punct ),RTCs
R502 T4161 T4162 punct (,1B
R503 T4122 T4123 aux to,proliferate
R504 T4123 T4121 xcomp proliferate,continue
R505 T4124 T4123 advmod inappropriately,proliferate
R506 T4162 T4156 parataxis 1B,factors
R507 T4125 T4121 cc and,continue
R508 T4126 T4127 nsubj some,die
R509 T4163 T4162 compound Figure,1B
R510 T4127 T4121 conj die,continue
R511 T4128 T4126 punct (,some
R512 T4129 T4130 nmod rod,cells
R513 T4164 T4162 punct ),1B
R514 T4130 T4126 appos cells,some
R515 T4131 T4129 punct ", ",rod
R516 T4132 T4129 conj ganglion,rod
R517 T4165 T4156 punct ", ",factors
R518 T4133 T4132 punct ", ",ganglion
R519 T4134 T4132 cc and,ganglion
R520 T4135 T4132 conj bipolar,ganglion
R521 T4166 T4167 advmod first,defined
R522 T4136 T4127 punct ),die
R523 T4137 T4127 prep by,die
R524 T4138 T4137 pobj apoptosis,by
R525 T4139 T4140 punct [,3
R526 T4167 T4156 acl defined,factors
R527 T4140 T4127 parataxis 3,die
R528 T4141 T4140 nummod 2,3
R529 T4142 T4140 punct ",",3
R530 T4168 T4167 prep as,defined
R531 T4143 T4140 punct ],3
R532 T4144 T4127 punct .,die
R533 T4146 T4147 nsubj Rb,controls
R534 T4169 T4170 compound transcription,factors
R535 T4148 T4149 det the,cycle
R536 T4149 T4147 dobj cycle,controls
R537 T4150 T4149 compound cell,cycle
R538 T4151 T4147 prep by,controls
R539 T4170 T4168 pobj factors,as
R540 T4152 T4151 pcomp binding,by
R541 T4153 T4152 cc and,binding
R542 T4154 T4152 conj inhibiting,binding
R543 T4171 T4172 dep that,bind
R544 T4155 T4156 compound E2f,factors
R545 T4156 T4154 dobj factors,inhibiting
R546 T4157 T4156 compound transcription,factors
R547 T4172 T4170 relcl bind,factors
R548 T4158 T4156 punct (,factors
R549 T4173 T4174 amod adenoviral,elements
R550 T4174 T4172 dobj elements,bind
R551 T4265 T4263 pobj extents,to
R552 T4175 T4176 npadvmod E2,regulatory
R553 T4266 T4256 prep in,rescued
R554 T4267 T4268 amod different,tissues
R555 T4268 T4266 pobj tissues,in
R556 T4176 T4174 amod regulatory,elements
R557 T4269 T4256 prep by,rescued
R558 T4270 T4269 pcomp knocking,by
R559 T4177 T4167 cc and,defined
R560 T4271 T4270 prt out,knocking
R561 T4272 T4270 dobj E2f1,knocking
R562 T4273 T4272 punct ", ",E2f1
R563 T4178 T4179 advmod subsequently,shown
R564 T4274 T4272 conj E2f2,E2f1
R565 T4179 T4167 conj shown,defined
R566 T4275 T4274 punct ", ",E2f2
R567 T4180 T4181 aux to,be
R568 T4276 T4274 cc or,E2f2
R569 T4277 T4274 conj E2f3,E2f2
R570 T4181 T4179 xcomp be,shown
R571 T4278 T4279 punct [,6
R572 T4279 T4270 parataxis 6,knocking
R573 T4182 T4183 amod critical,regulators
R574 T4280 T4281 punct –,9
R575 T4281 T4279 prep 9,6
R576 T4282 T4279 punct ],6
R577 T4283 T4256 punct ", ",rescued
R578 T4183 T4181 attr regulators,be
R579 T4284 T4256 cc but,rescued
R580 T4285 T4286 det which,member
R581 T4286 T4287 dep member,drive
R582 T4184 T4185 compound cell,cycle
R583 T4287 T4291 csubj drive,is
R584 T4288 T4286 punct (,member
R585 T4289 T4286 nmod s,member
R586 T4290 T4286 punct ),member
R587 T4291 T4256 conj is,rescued
R588 T4292 T4287 dobj division,drive
R589 T4185 T4183 compound cycle,regulators
R590 T4293 T4287 prep in,drive
R591 T4294 T4295 compound Rb,KO
R592 T4186 T4187 punct [,5
R593 T4295 T4296 compound KO,RTCs
R594 T4296 T4293 pobj RTCs,in
R595 T4297 T4291 acomp unknown,is
R596 T4298 T4291 punct .,is
R597 T4187 T4181 parataxis 5,be
R598 T4300 T4301 amod Other,members
R599 T4188 T4187 nummod 4,5
R600 T4301 T4302 nsubjpass members,known
R601 T4303 T4301 prep of,members
R602 T4189 T4187 punct ",",5
R603 T4304 T4305 det the,family
R604 T4305 T4303 pobj family,of
R605 T4190 T4187 punct ],5
R606 T4306 T4301 punct ", ",members
R607 T4307 T4308 amod such,as
R608 T4308 T4301 prep as,members
R609 T4191 T4147 punct .,controls
R610 T4309 T4308 pobj E2f4,as
R611 T4310 T4309 cc and,E2f4
R612 T4311 T4309 conj E2f5,E2f4
R613 T4193 T4194 nsubj E2fs,bind
R614 T4312 T4302 punct ", ",known
R615 T4313 T4302 auxpass are,known
R616 T4314 T4302 prep as,known
R617 T4315 T4316 punct “,E2fs
R618 T4316 T4314 pobj E2fs,as
R619 T4195 T4194 prep to,bind
R620 T4317 T4316 amod repressive,E2fs
R621 T4318 T4302 punct ”,known
R622 T4319 T4320 mark because,are
R623 T4320 T4302 advcl are,known
R624 T4196 T4195 pobj DNA,to
R625 T4321 T4320 nsubj they,are
R626 T4322 T4323 amod weak,activators
R627 T4197 T4194 prep as,bind
R628 T4323 T4320 attr activators,are
R629 T4324 T4320 cc and,are
R630 T4325 T4320 conj appear,are
R631 T4198 T4197 pobj heterodimers,as
R632 T4326 T4327 aux to,involved
R633 T4327 T4325 xcomp involved,appear
R634 T4328 T4327 auxpass be,involved
R635 T4329 T4327 advmod primarily,involved
R636 T4330 T4327 prep in,involved
R637 T4199 T4198 prep with,heterodimers
R638 T4331 T4332 compound gene,silencing
R639 T4332 T4330 pobj silencing,in
R640 T4333 T4327 prep in,involved
R641 T4200 T4199 pobj proteins,with
R642 T4334 T4335 amod quiescent,cells
R643 T4335 T4333 pobj cells,in
R644 T4201 T4200 prep of,proteins
R645 T4336 T4334 cc or,quiescent
R646 T4337 T4334 conj differentiated,quiescent
R647 T4202 T4203 det the,family
R648 T4338 T4302 punct .,known
R650 T4203 T4201 pobj family,of
R653 T4204 T4203 amod related,family
R656 T4205 T4203 compound Tfdp,family
R658 T4206 T4194 punct .,bind
R661 T4208 T4209 nsubj E2f1,are
R666 T4210 T4208 punct ", ",E2f1
R670 T4211 T4208 conj E2f2,E2f1
R672 T4212 T4211 punct ", ",E2f2
R675 T4213 T4211 cc and,E2f2
R679 T4214 T4211 conj E2f3a,E2f2
R683 T4215 T4209 punct “,are
R688 T4216 T4217 compound activating,E2fs
R689 T4217 T4209 attr E2fs,are
R692 T4218 T4217 punct ”,E2fs
R695 T4219 T4220 dep that,required
R698 T4220 T4217 relcl required,E2fs
R701 T4221 T4220 auxpass are,required
R706 T4222 T4220 prep for,required
R710 T4223 T4224 compound fibroblast,division
R714 T4224 T4222 pobj division,for
R718 T4225 T4209 punct .,are
R722 T4227 T4228 nsubj They,are
R727 T4229 T4230 amod strong,activators
R732 T4230 T4228 attr activators,are
R736 T4231 T4230 amod transcriptional,activators
R741 T4232 T4233 dep that,drive
R745 T4233 T4230 relcl drive,activators
R749 T4234 T4233 aux can,drive
R752 T4235 T4236 compound G0,fibroblasts
R756 T4236 T4233 dobj fibroblasts,drive
R760 T4237 T4233 prep into,drive
R764 T4238 T4237 pobj cycle,into
R768 T4239 T4228 punct ", ",are
R769 T4240 T4228 cc and,are
R771 T4241 T4242 auxpass are,inhibited
R773 T4242 T4228 conj inhibited,are
R776 T4243 T4244 advmod when,bound
R780 T4244 T4242 advcl bound,inhibited
R783 T4245 T4244 prep to,bound
R787 T4246 T4245 pobj Rb,to
R794 T4247 T4248 punct [,5
R797 T4248 T4244 parataxis 5,bound
R799 T4249 T4248 nummod 4,5
R803 T4250 T4248 punct ",",5
R807 T4251 T4248 punct ],5
R810 T4252 T4228 punct .,are
R814 T4254 T4255 amod Ectopic,division
R819 T4255 T4256 nsubjpass division,rescued
R821 T4257 T4255 prep in,division
R822 T4258 T4259 compound Rb,KO
R823 T4259 T4260 compound KO,embryos
R827 T4260 T4257 pobj embryos,in
R831 T4261 T4256 aux can,rescued
R835 T4262 T4256 auxpass be,rescued
R838 T4263 T4256 prep to,rescued
R845 T4264 T4265 amod various,extents