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PMC:1914394 / 53022-54071 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T27802 0-6 NNS denotes Others
T27804 7-11 VBP denotes have
T27803 12-21 VBN denotes suggested
T27805 22-26 IN denotes that
T27807 27-29 NN denotes Rb
T27806 30-38 VBZ denotes promotes
T27808 39-54 NN denotes differentiation
T27809 55-57 IN denotes in
T27810 58-70 JJ denotes non-neuronal
T27811 71-76 NNS denotes cells
T27812 77-84 IN denotes through
T27813 85-88 NN denotes E2f
T27815 88-89 HYPH denotes -
T27814 89-100 JJ denotes independent
T27816 101-106 NNS denotes means
T27817 107-108 -LRB- denotes [
T27818 108-110 CD denotes 31
T27819 110-111 SYM denotes –
T27820 111-113 CD denotes 33
T27821 113-114 -RRB- denotes ]
T27822 114-115 . denotes .
T27823 115-261 sentence denotes However, these studies did not assess whether these cell types differentiate normally if Rb is deleted along with one or more E2f family members.
T27824 116-123 RB denotes However
T27826 123-125 , denotes ,
T27827 125-130 DT denotes these
T27828 131-138 NNS denotes studies
T27829 139-142 VBD denotes did
T27830 143-146 RB denotes not
T27825 147-153 VB denotes assess
T27831 154-161 IN denotes whether
T27833 162-167 DT denotes these
T27835 168-172 NN denotes cell
T27834 173-178 NNS denotes types
T27832 179-192 VBP denotes differentiate
T27836 193-201 RB denotes normally
T27837 202-204 IN denotes if
T27839 205-207 NN denotes Rb
T27840 208-210 VBZ denotes is
T27838 211-218 VBN denotes deleted
T27841 219-224 IN denotes along
T27842 225-229 IN denotes with
T27843 230-233 CD denotes one
T27845 234-236 CC denotes or
T27846 237-241 JJR denotes more
T27847 242-245 NN denotes E2f
T27848 246-252 NN denotes family
T27844 253-260 NNS denotes members
T27849 260-261 . denotes .
T27850 261-352 sentence denotes One study reported that Rb mutants that do not bind E2f still induce differentiation [30].
T27851 262-265 CD denotes One
T27852 266-271 NN denotes study
T27853 272-280 VBD denotes reported
T27854 281-285 IN denotes that
T27856 286-288 NN denotes Rb
T27857 289-296 NNS denotes mutants
T27858 297-301 WDT denotes that
T27860 302-304 VBP denotes do
T27861 305-308 RB denotes not
T27859 309-313 VB denotes bind
T27862 314-317 NN denotes E2f
T27863 318-323 RB denotes still
T27855 324-330 VBP denotes induce
T27864 331-346 NN denotes differentiation
T27865 347-348 -LRB- denotes [
T27866 348-350 CD denotes 30
T27867 350-351 -RRB- denotes ]
T27868 351-352 . denotes .
T27869 352-534 sentence denotes However, the binding assays were performed in solution, and we have found that several of these mutants do bind E2f, albeit weakly, on chromatin (T. Yu and R. B., unpublished data).
T27870 353-360 RB denotes However
T27872 360-362 , denotes ,
T27873 362-365 DT denotes the
T27875 366-373 NN denotes binding
T27874 374-380 NNS denotes assays
T27876 381-385 VBD denotes were
T27871 386-395 VBN denotes performed
T27877 396-398 IN denotes in
T27878 399-407 NN denotes solution
T27879 407-409 , denotes ,
T27880 409-412 CC denotes and
T27881 413-415 PRP denotes we
T27883 416-420 VBP denotes have
T27882 421-426 VBN denotes found
T27884 427-431 IN denotes that
T27886 432-439 JJ denotes several
T27887 440-442 IN denotes of
T27888 443-448 DT denotes these
T27889 449-456 NNS denotes mutants
T27890 457-459 VBP denotes do
T27885 460-464 VB denotes bind
T27891 465-468 NN denotes E2f
T27892 468-470 , denotes ,
T27893 470-476 IN denotes albeit
T27894 477-483 RB denotes weakly
T27895 483-485 , denotes ,
T27896 485-487 IN denotes on
T27897 488-497 NN denotes chromatin
T27898 498-499 -LRB- denotes (
T27899 499-501 NNP denotes T.
T27900 502-504 NNP denotes Yu
T27901 505-508 CC denotes and
T27902 509-511 NNP denotes R.
T27903 512-514 NNP denotes B.
T27904 514-516 , denotes ,
T27905 516-527 JJ denotes unpublished
T27906 528-532 NNS denotes data
T27907 532-533 -RRB- denotes )
T27908 533-534 . denotes .
T27909 534-732 sentence denotes It is possible that Rb-mediated potentiation of tissue-specific transcription factors may, at least in some cases, be a redundant activity, and that the only critical Rb function is to inhibit E2f.
T27910 535-537 PRP denotes It
T27911 538-540 VBZ denotes is
T27912 541-549 JJ denotes possible
T27913 550-554 IN denotes that
T27915 555-557 NN denotes Rb
T27917 557-558 HYPH denotes -
T27916 558-566 VBN denotes mediated
T27918 567-579 NN denotes potentiation
T27919 580-582 IN denotes of
T27920 583-589 NN denotes tissue
T27922 589-590 HYPH denotes -
T27921 590-598 JJ denotes specific
T27924 599-612 NN denotes transcription
T27923 613-620 NNS denotes factors
T27925 621-624 MD denotes may
T27926 624-626 , denotes ,
T27927 626-628 RB denotes at
T27928 629-634 RBS denotes least
T27929 635-637 IN denotes in
T27930 638-642 DT denotes some
T27931 643-648 NNS denotes cases
T27932 648-650 , denotes ,
T27914 650-652 VB denotes be
T27933 653-654 DT denotes a
T27935 655-664 JJ denotes redundant
T27934 665-673 NN denotes activity
T27936 673-675 , denotes ,
T27937 675-678 CC denotes and
T27938 679-683 IN denotes that
T27940 684-687 DT denotes the
T27942 688-692 JJ denotes only
T27943 693-701 JJ denotes critical
T27944 702-704 NN denotes Rb
T27941 705-713 NN denotes function
T27939 714-716 VBZ denotes is
T27945 717-719 TO denotes to
T27946 720-727 VB denotes inhibit
T27947 728-731 NN denotes E2f
T27948 731-732 . denotes .
T27949 732-870 sentence denotes Our study is the first to our knowledge to assess comprehensively whether Rb KO cells can differentiate in the absence of different E2fs.
T27950 733-736 PRP$ denotes Our
T27951 737-742 NN denotes study
T27952 743-745 VBZ denotes is
T27953 746-749 DT denotes the
T27954 750-755 JJ denotes first
T27955 756-758 IN denotes to
T27956 759-762 PRP$ denotes our
T27957 763-772 NN denotes knowledge
T27958 773-775 TO denotes to
T27959 776-782 VB denotes assess
T27960 783-798 RB denotes comprehensively
T27961 799-806 IN denotes whether
T27963 807-809 NN denotes Rb
T27964 810-812 NN denotes KO
T27965 813-818 NNS denotes cells
T27966 819-822 MD denotes can
T27962 823-836 VB denotes differentiate
T27967 837-839 IN denotes in
T27968 840-843 DT denotes the
T27969 844-851 NN denotes absence
T27970 852-854 IN denotes of
T27971 855-864 JJ denotes different
T27972 865-869 NNS denotes E2fs
T27973 869-870 . denotes .
T27974 870-1049 sentence denotes In light of our findings, it will be important to reassess differentiation defects in other Rb KO tissues in the absence of individual and combined activating E2f family members.
T27975 871-873 IN denotes In
T27977 874-879 NN denotes light
T27978 880-882 IN denotes of
T27979 883-886 PRP$ denotes our
T27980 887-895 NNS denotes findings
T27981 895-897 , denotes ,
T27982 897-899 PRP denotes it
T27983 900-904 MD denotes will
T27976 905-907 VB denotes be
T27984 908-917 JJ denotes important
T27985 918-920 TO denotes to
T27986 921-929 VB denotes reassess
T27987 930-945 NN denotes differentiation
T27988 946-953 NNS denotes defects
T27989 954-956 IN denotes in
T27990 957-962 JJ denotes other
T27992 963-965 NN denotes Rb
T27993 966-968 NN denotes KO
T27991 969-976 NNS denotes tissues
T27994 977-979 IN denotes in
T27995 980-983 DT denotes the
T27996 984-991 NN denotes absence
T27997 992-994 IN denotes of
T27998 995-1005 JJ denotes individual
T28000 1006-1009 CC denotes and
T28001 1010-1018 VBN denotes combined
T28002 1019-1029 VBG denotes activating
T28003 1030-1033 NN denotes E2f
T28004 1034-1040 NN denotes family
T27999 1041-1048 NNS denotes members
T28005 1048-1049 . denotes .
R8256 T27802 T27803 nsubj Others,suggested
R8257 T27804 T27803 aux have,suggested
R8258 T27805 T27806 mark that,promotes
R8259 T27806 T27803 ccomp promotes,suggested
R8260 T27807 T27806 nsubj Rb,promotes
R8261 T27808 T27806 dobj differentiation,promotes
R8262 T27809 T27806 prep in,promotes
R8263 T27810 T27811 amod non-neuronal,cells
R8264 T27811 T27809 pobj cells,in
R8265 T27812 T27806 prep through,promotes
R8266 T27813 T27814 npadvmod E2f,independent
R8267 T27814 T27816 amod independent,means
R8268 T27815 T27814 punct -,independent
R8269 T27816 T27812 pobj means,through
R8270 T27817 T27818 punct [,31
R8271 T27818 T27803 parataxis 31,suggested
R8272 T27819 T27820 punct –,33
R8273 T27820 T27818 prep 33,31
R8274 T27821 T27818 punct ],31
R8275 T27822 T27803 punct .,suggested
R8276 T27824 T27825 advmod However,assess
R8277 T27826 T27825 punct ", ",assess
R8278 T27827 T27828 det these,studies
R8279 T27828 T27825 nsubj studies,assess
R8280 T27829 T27825 aux did,assess
R8281 T27830 T27825 neg not,assess
R8282 T27831 T27832 mark whether,differentiate
R8283 T27832 T27825 ccomp differentiate,assess
R8284 T27833 T27834 det these,types
R8285 T27834 T27832 nsubj types,differentiate
R8286 T27835 T27834 compound cell,types
R8287 T27836 T27832 advmod normally,differentiate
R8288 T27837 T27838 mark if,deleted
R8289 T27838 T27832 advcl deleted,differentiate
R8290 T27839 T27838 nsubjpass Rb,deleted
R8291 T27840 T27838 auxpass is,deleted
R8292 T27841 T27838 prep along,deleted
R8293 T27842 T27841 prep with,along
R8294 T27843 T27844 nummod one,members
R8295 T27844 T27842 pobj members,with
R8296 T27845 T27843 cc or,one
R8297 T27846 T27843 conj more,one
R8298 T27847 T27844 compound E2f,members
R8299 T27848 T27844 compound family,members
R8300 T27849 T27825 punct .,assess
R8301 T27851 T27852 nummod One,study
R8302 T27852 T27853 nsubj study,reported
R8303 T27854 T27855 mark that,induce
R8304 T27855 T27853 ccomp induce,reported
R8305 T27856 T27857 compound Rb,mutants
R8306 T27857 T27855 nsubj mutants,induce
R8307 T27858 T27859 dep that,bind
R8308 T27859 T27857 relcl bind,mutants
R8309 T27860 T27859 aux do,bind
R8310 T27861 T27859 neg not,bind
R8311 T27862 T27859 dobj E2f,bind
R8312 T27863 T27855 advmod still,induce
R8313 T27864 T27855 dobj differentiation,induce
R8314 T27865 T27866 punct [,30
R8315 T27866 T27855 parataxis 30,induce
R8316 T27867 T27866 punct ],30
R8317 T27868 T27853 punct .,reported
R8318 T27870 T27871 advmod However,performed
R8319 T27872 T27871 punct ", ",performed
R8320 T27873 T27874 det the,assays
R8321 T27874 T27871 nsubjpass assays,performed
R8322 T27875 T27874 compound binding,assays
R8323 T27876 T27871 auxpass were,performed
R8324 T27877 T27871 prep in,performed
R8325 T27878 T27877 pobj solution,in
R8326 T27879 T27871 punct ", ",performed
R8327 T27880 T27871 cc and,performed
R8328 T27881 T27882 nsubj we,found
R8329 T27882 T27871 conj found,performed
R8330 T27883 T27882 aux have,found
R8331 T27884 T27885 mark that,bind
R8332 T27885 T27882 ccomp bind,found
R8333 T27886 T27885 nsubj several,bind
R8334 T27887 T27886 prep of,several
R8335 T27888 T27889 det these,mutants
R8336 T27889 T27887 pobj mutants,of
R8337 T27890 T27885 aux do,bind
R8338 T27891 T27885 dobj E2f,bind
R8339 T27892 T27885 punct ", ",bind
R8340 T27893 T27885 prep albeit,bind
R8341 T27894 T27893 pcomp weakly,albeit
R8342 T27895 T27885 punct ", ",bind
R8343 T27896 T27885 prep on,bind
R8344 T27897 T27896 pobj chromatin,on
R8345 T27898 T27899 punct (,T.
R8346 T27899 T27885 meta T.,bind
R8347 T27900 T27899 nmod Yu,T.
R8348 T27901 T27899 cc and,T.
R8349 T27902 T27899 conj R.,T.
R8350 T27903 T27902 nmod B.,R.
R8351 T27904 T27902 punct ", ",R.
R8352 T27905 T27906 amod unpublished,data
R8353 T27906 T27902 conj data,R.
R8354 T27907 T27906 punct ),data
R8355 T27908 T27882 punct .,found
R8356 T27910 T27911 nsubj It,is
R8357 T27912 T27911 acomp possible,is
R8358 T27913 T27914 mark that,be
R8359 T27914 T27911 advcl be,is
R8360 T27915 T27916 npadvmod Rb,mediated
R8361 T27916 T27918 amod mediated,potentiation
R8362 T27917 T27916 punct -,mediated
R8363 T27918 T27914 nsubj potentiation,be
R8364 T27919 T27918 prep of,potentiation
R8365 T27920 T27921 npadvmod tissue,specific
R8366 T27921 T27923 amod specific,factors
R8367 T27922 T27921 punct -,specific
R8368 T27923 T27919 pobj factors,of
R8369 T27924 T27923 compound transcription,factors
R8370 T27925 T27914 aux may,be
R8371 T27926 T27914 punct ", ",be
R8372 T27927 T27928 advmod at,least
R8373 T27928 T27929 advmod least,in
R8374 T27929 T27914 prep in,be
R8375 T27930 T27931 det some,cases
R8376 T27931 T27929 pobj cases,in
R8377 T27932 T27914 punct ", ",be
R8378 T27933 T27934 det a,activity
R8379 T27934 T27914 attr activity,be
R8380 T27935 T27934 amod redundant,activity
R8381 T27936 T27914 punct ", ",be
R8382 T27937 T27914 cc and,be
R8383 T27938 T27939 mark that,is
R8384 T27939 T27914 conj is,be
R8385 T27940 T27941 det the,function
R8386 T27941 T27939 nsubj function,is
R8387 T27942 T27941 amod only,function
R8388 T27943 T27941 amod critical,function
R8389 T27944 T27941 compound Rb,function
R8390 T27945 T27946 aux to,inhibit
R8391 T27946 T27939 xcomp inhibit,is
R8392 T27947 T27946 dobj E2f,inhibit
R8393 T27948 T27911 punct .,is
R8394 T27950 T27951 poss Our,study
R8395 T27951 T27952 nsubj study,is
R8396 T27953 T27954 det the,first
R8397 T27954 T27952 attr first,is
R8398 T27955 T27954 prep to,first
R8399 T27956 T27957 poss our,knowledge
R8400 T27957 T27955 pobj knowledge,to
R8401 T27958 T27959 aux to,assess
R8402 T27959 T27954 advcl assess,first
R8403 T27960 T27959 advmod comprehensively,assess
R8404 T27961 T27962 mark whether,differentiate
R8405 T27962 T27959 ccomp differentiate,assess
R8406 T27963 T27964 compound Rb,KO
R8407 T27964 T27965 compound KO,cells
R8408 T27965 T27962 nsubj cells,differentiate
R8409 T27966 T27962 aux can,differentiate
R8410 T27967 T27962 prep in,differentiate
R8411 T27968 T27969 det the,absence
R8412 T27969 T27967 pobj absence,in
R8413 T27970 T27969 prep of,absence
R8414 T27971 T27972 amod different,E2fs
R8415 T27972 T27970 pobj E2fs,of
R8416 T27973 T27952 punct .,is
R8417 T27975 T27976 prep In,be
R8418 T27977 T27975 pobj light,In
R8419 T27978 T27977 prep of,light
R8420 T27979 T27980 poss our,findings
R8421 T27980 T27978 pobj findings,of
R8422 T27981 T27976 punct ", ",be
R8423 T27982 T27976 nsubj it,be
R8424 T27983 T27976 aux will,be
R8425 T27984 T27976 acomp important,be
R8426 T27985 T27986 aux to,reassess
R8427 T27986 T27976 xcomp reassess,be
R8428 T27987 T27988 compound differentiation,defects
R8429 T27988 T27986 dobj defects,reassess
R8430 T27989 T27988 prep in,defects
R8431 T27990 T27991 amod other,tissues
R8432 T27991 T27989 pobj tissues,in
R8433 T27992 T27993 compound Rb,KO
R8434 T27993 T27991 compound KO,tissues
R8435 T27994 T27986 prep in,reassess
R8436 T27995 T27996 det the,absence
R8437 T27996 T27994 pobj absence,in
R8438 T27997 T27996 prep of,absence
R8439 T27998 T27999 amod individual,members
R8440 T27999 T27997 pobj members,of
R8441 T28000 T27998 cc and,individual
R8442 T28001 T27998 conj combined,individual
R8443 T28002 T27999 amod activating,members
R8444 T28003 T27999 compound E2f,members
R8445 T28004 T27999 compound family,members
R8446 T28005 T27976 punct .,be