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PMC:1914394 / 52211-52986 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T27218 0-3 WRB denotes How
T27220 4-8 VBZ denotes Does
T27221 9-14 NN denotes E2f3a
T27219 15-22 VB denotes Perturb
T27222 23-26 NN denotes SAC
T27223 27-42 NN denotes Differentiation
T27224 42-43 . denotes ?
T27225 43-261 sentence denotes E2f3a could disrupt SAC differentiation through its well known role as a transcriptional activator, or, in view of the discovery that it is partially cytoplasmic, E2f3a may affect processes other than gene regulation.
T27226 44-49 NN denotes E2f3a
T27228 50-55 MD denotes could
T27227 56-63 VB denotes disrupt
T27229 64-67 NN denotes SAC
T27230 68-83 NN denotes differentiation
T27231 84-91 IN denotes through
T27232 92-95 PRP$ denotes its
T27234 96-100 RB denotes well
T27235 101-106 VBN denotes known
T27233 107-111 NN denotes role
T27236 112-114 IN denotes as
T27237 115-116 DT denotes a
T27239 117-132 JJ denotes transcriptional
T27238 133-142 NN denotes activator
T27240 142-144 , denotes ,
T27241 144-146 CC denotes or
T27242 146-148 , denotes ,
T27243 148-150 IN denotes in
T27245 151-155 NN denotes view
T27246 156-158 IN denotes of
T27247 159-162 DT denotes the
T27248 163-172 NN denotes discovery
T27249 173-177 IN denotes that
T27251 178-180 PRP denotes it
T27250 181-183 VBZ denotes is
T27252 184-193 RB denotes partially
T27253 194-205 JJ denotes cytoplasmic
T27254 205-207 , denotes ,
T27255 207-212 NN denotes E2f3a
T27256 213-216 MD denotes may
T27244 217-223 VB denotes affect
T27257 224-233 NNS denotes processes
T27258 234-239 JJ denotes other
T27259 240-244 IN denotes than
T27260 245-249 NN denotes gene
T27261 250-260 NN denotes regulation
T27262 260-261 . denotes .
T27263 261-451 sentence denotes Both scenarios are feasible since E2fs regulate differentiation genes [44–48], and cell cycle regulators, such as Cdkn1b, have cytoplasmic activities that influence differentiation [68,69].
T27264 262-266 DT denotes Both
T27265 267-276 NNS denotes scenarios
T27266 277-280 VBP denotes are
T27267 281-289 JJ denotes feasible
T27268 290-295 IN denotes since
T27270 296-300 NNS denotes E2fs
T27269 301-309 VBP denotes regulate
T27271 310-325 NN denotes differentiation
T27272 326-331 NNS denotes genes
T27273 332-333 -LRB- denotes [
T27274 333-335 CD denotes 44
T27275 335-336 SYM denotes –
T27276 336-338 CD denotes 48
T27277 338-339 -RRB- denotes ]
T27278 339-341 , denotes ,
T27279 341-344 CC denotes and
T27280 345-349 NN denotes cell
T27281 350-355 NN denotes cycle
T27282 356-366 NNS denotes regulators
T27284 366-368 , denotes ,
T27285 368-372 JJ denotes such
T27286 373-375 IN denotes as
T27287 376-382 NN denotes Cdkn1b
T27288 382-384 , denotes ,
T27283 384-388 VBP denotes have
T27289 389-400 JJ denotes cytoplasmic
T27290 401-411 NNS denotes activities
T27291 412-416 WDT denotes that
T27292 417-426 VBP denotes influence
T27293 427-442 NN denotes differentiation
T27294 443-444 -LRB- denotes [
T27296 444-446 CD denotes 68
T27297 446-447 , denotes ,
T27295 447-449 CD denotes 69
T27298 449-450 -RRB- denotes ]
T27299 450-451 . denotes .
T27300 451-573 sentence denotes Many transcription factors shuttle between nucleus and cytoplasm during neurogenesis (e.g., [70] and references therein).
T27301 452-456 JJ denotes Many
T27303 457-470 NN denotes transcription
T27302 471-478 NNS denotes factors
T27304 479-486 VBP denotes shuttle
T27305 487-494 IN denotes between
T27306 495-502 NN denotes nucleus
T27307 503-506 CC denotes and
T27308 507-516 NN denotes cytoplasm
T27309 517-523 IN denotes during
T27310 524-536 NN denotes neurogenesis
T27311 537-538 -LRB- denotes (
T27313 538-542 FW denotes e.g.
T27314 542-544 , denotes ,
T27315 544-545 -LRB- denotes [
T27312 545-547 CD denotes 70
T27316 547-548 -RRB- denotes ]
T27317 549-552 CC denotes and
T27318 553-563 NNS denotes references
T27319 564-571 RB denotes therein
T27320 571-572 -RRB- denotes )
T27321 572-573 . denotes .
T27322 573-775 sentence denotes It may be difficult to identify E2f3a-specific target genes or cytoplasmic proteins in SACs since these neurons are a small proportion (<1%) of the total retina and only ~5.2% of amacrine neurons [38].
T27323 574-576 PRP denotes It
T27325 577-580 MD denotes may
T27324 581-583 VB denotes be
T27326 584-593 JJ denotes difficult
T27327 594-596 TO denotes to
T27328 597-605 VB denotes identify
T27329 606-611 NN denotes E2f3a
T27331 611-612 HYPH denotes -
T27330 612-620 JJ denotes specific
T27333 621-627 NN denotes target
T27332 628-633 NNS denotes genes
T27334 634-636 CC denotes or
T27335 637-648 JJ denotes cytoplasmic
T27336 649-657 NN denotes proteins
T27337 658-660 IN denotes in
T27338 661-665 NNS denotes SACs
T27339 666-671 IN denotes since
T27341 672-677 DT denotes these
T27342 678-685 NNS denotes neurons
T27340 686-689 VBP denotes are
T27343 690-691 DT denotes a
T27345 692-697 JJ denotes small
T27344 698-708 NN denotes proportion
T27346 709-710 -LRB- denotes (
T27347 710-711 SYM denotes <
T27348 711-712 CD denotes 1
T27349 712-713 NN denotes %
T27350 713-714 -RRB- denotes )
T27351 715-717 IN denotes of
T27352 718-721 DT denotes the
T27354 722-727 JJ denotes total
T27353 728-734 NN denotes retina
T27355 735-738 CC denotes and
T27356 739-743 RB denotes only
T27358 744-745 SYM denotes ~
T27357 745-748 CD denotes 5.2
T27359 748-749 NN denotes %
T27360 750-752 IN denotes of
T27361 753-761 JJ denotes amacrine
T27362 762-769 NNS denotes neurons
T27363 770-771 -LRB- denotes [
T27364 771-773 CD denotes 38
T27365 773-774 -RRB- denotes ]
T27366 774-775 . denotes .
R8110 T27218 T27219 advmod How,Perturb
R8111 T27220 T27219 aux Does,Perturb
R8112 T27221 T27219 nsubj E2f3a,Perturb
R8113 T27222 T27223 compound SAC,Differentiation
R8114 T27223 T27219 dobj Differentiation,Perturb
R8115 T27224 T27219 punct ?,Perturb
R8116 T27226 T27227 nsubj E2f3a,disrupt
R8117 T27228 T27227 aux could,disrupt
R8118 T27229 T27230 compound SAC,differentiation
R8119 T27230 T27227 dobj differentiation,disrupt
R8120 T27231 T27227 prep through,disrupt
R8121 T27232 T27233 poss its,role
R8122 T27233 T27231 pobj role,through
R8123 T27234 T27235 advmod well,known
R8124 T27235 T27233 amod known,role
R8125 T27236 T27233 prep as,role
R8126 T27237 T27238 det a,activator
R8127 T27238 T27236 pobj activator,as
R8128 T27239 T27238 amod transcriptional,activator
R8129 T27240 T27227 punct ", ",disrupt
R8130 T27241 T27227 cc or,disrupt
R8131 T27242 T27227 punct ", ",disrupt
R8132 T27243 T27244 prep in,affect
R8133 T27244 T27227 conj affect,disrupt
R8134 T27245 T27243 pobj view,in
R8135 T27246 T27245 prep of,view
R8136 T27247 T27248 det the,discovery
R8137 T27248 T27246 pobj discovery,of
R8138 T27249 T27250 mark that,is
R8139 T27250 T27248 acl is,discovery
R8140 T27251 T27250 nsubj it,is
R8141 T27252 T27253 advmod partially,cytoplasmic
R8142 T27253 T27250 acomp cytoplasmic,is
R8143 T27254 T27244 punct ", ",affect
R8144 T27255 T27244 nsubj E2f3a,affect
R8145 T27256 T27244 aux may,affect
R8146 T27257 T27244 dobj processes,affect
R8147 T27258 T27257 amod other,processes
R8148 T27259 T27258 prep than,other
R8149 T27260 T27261 compound gene,regulation
R8150 T27261 T27259 pobj regulation,than
R8151 T27262 T27244 punct .,affect
R8152 T27264 T27265 det Both,scenarios
R8153 T27265 T27266 nsubj scenarios,are
R8154 T27267 T27266 acomp feasible,are
R8155 T27268 T27269 mark since,regulate
R8156 T27269 T27266 advcl regulate,are
R8157 T27270 T27269 nsubj E2fs,regulate
R8158 T27271 T27272 compound differentiation,genes
R8159 T27272 T27269 dobj genes,regulate
R8160 T27273 T27274 punct [,44
R8161 T27274 T27266 parataxis 44,are
R8162 T27275 T27276 punct –,48
R8163 T27276 T27274 prep 48,44
R8164 T27277 T27274 punct ],44
R8165 T27278 T27266 punct ", ",are
R8166 T27279 T27266 cc and,are
R8167 T27280 T27281 compound cell,cycle
R8168 T27281 T27282 compound cycle,regulators
R8169 T27282 T27283 nsubj regulators,have
R8170 T27283 T27266 conj have,are
R8171 T27284 T27282 punct ", ",regulators
R8172 T27285 T27286 amod such,as
R8173 T27286 T27282 prep as,regulators
R8174 T27287 T27286 pobj Cdkn1b,as
R8175 T27288 T27283 punct ", ",have
R8176 T27289 T27290 amod cytoplasmic,activities
R8177 T27290 T27283 dobj activities,have
R8178 T27291 T27292 dep that,influence
R8179 T27292 T27290 relcl influence,activities
R8180 T27293 T27292 dobj differentiation,influence
R8181 T27294 T27295 punct [,69
R8182 T27295 T27283 parataxis 69,have
R8183 T27296 T27295 nummod 68,69
R8184 T27297 T27295 punct ",",69
R8185 T27298 T27295 punct ],69
R8186 T27299 T27283 punct .,have
R8187 T27301 T27302 amod Many,factors
R8188 T27302 T27304 nsubj factors,shuttle
R8189 T27303 T27302 compound transcription,factors
R8190 T27305 T27304 prep between,shuttle
R8191 T27306 T27305 pobj nucleus,between
R8192 T27307 T27306 cc and,nucleus
R8193 T27308 T27306 conj cytoplasm,nucleus
R8194 T27309 T27304 prep during,shuttle
R8195 T27310 T27309 pobj neurogenesis,during
R8196 T27311 T27312 punct (,70
R8197 T27312 T27304 parataxis 70,shuttle
R8198 T27313 T27312 advmod e.g.,70
R8199 T27314 T27312 punct ", ",70
R8200 T27315 T27312 punct [,70
R8201 T27316 T27312 punct ],70
R8202 T27317 T27312 cc and,70
R8203 T27318 T27312 conj references,70
R8204 T27319 T27318 advmod therein,references
R8205 T27320 T27312 punct ),70
R8206 T27321 T27304 punct .,shuttle
R8207 T27323 T27324 nsubj It,be
R8208 T27325 T27324 aux may,be
R8209 T27326 T27324 acomp difficult,be
R8210 T27327 T27328 aux to,identify
R8211 T27328 T27324 xcomp identify,be
R8212 T27329 T27330 npadvmod E2f3a,specific
R8213 T27330 T27332 amod specific,genes
R8214 T27331 T27330 punct -,specific
R8215 T27332 T27328 dobj genes,identify
R8216 T27333 T27332 compound target,genes
R8217 T27334 T27332 cc or,genes
R8218 T27335 T27336 amod cytoplasmic,proteins
R8219 T27336 T27332 conj proteins,genes
R8220 T27337 T27328 prep in,identify
R8221 T27338 T27337 pobj SACs,in
R8222 T27339 T27340 mark since,are
R8223 T27340 T27324 advcl are,be
R8224 T27341 T27342 det these,neurons
R8225 T27342 T27340 nsubj neurons,are
R8226 T27343 T27344 det a,proportion
R8227 T27344 T27340 attr proportion,are
R8228 T27345 T27344 amod small,proportion
R8229 T27346 T27344 punct (,proportion
R8230 T27347 T27348 punct <,1
R8231 T27348 T27349 nummod 1,%
R8232 T27349 T27344 appos %,proportion
R8233 T27350 T27344 punct ),proportion
R8234 T27351 T27344 prep of,proportion
R8235 T27352 T27353 det the,retina
R8236 T27353 T27351 pobj retina,of
R8237 T27354 T27353 amod total,retina
R8238 T27355 T27344 cc and,proportion
R8239 T27356 T27357 advmod only,5.2
R8240 T27357 T27359 nummod 5.2,%
R8241 T27358 T27357 punct ~,5.2
R8242 T27359 T27344 conj %,proportion
R8243 T27360 T27359 prep of,%
R8244 T27361 T27362 amod amacrine,neurons
R8245 T27362 T27360 pobj neurons,of
R8246 T27363 T27364 punct [,38
R8247 T27364 T27340 parataxis 38,are
R8248 T27365 T27364 punct ],38
R8249 T27366 T27324 punct .,be