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PMC:1914394 / 49241-50274 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T25722 0-3 DT denotes The
T25724 4-15 JJ denotes subcellular
T25723 16-24 NN denotes location
T25726 25-27 IN denotes of
T25727 28-31 NN denotes E2f
T25728 32-40 NNS denotes isoforms
T25729 41-44 VBZ denotes has
T25730 45-48 RB denotes not
T25731 49-51 IN denotes to
T25732 52-55 PRP$ denotes our
T25733 56-65 NN denotes knowledge
T25734 66-70 VBN denotes been
T25725 71-80 VBN denotes addressed
T25735 81-87 RB denotes before
T25736 87-88 . denotes .
T25737 88-310 sentence denotes E2f3a and E2f3b share 110 C-terminal amino acids that encode the NLS, DNA-binding, marked box, transactivation, and Rb-binding domains [16], yet they exhibit different subcellular distribution in developing retinal cells.
T25738 89-94 NN denotes E2f3a
T25740 95-98 CC denotes and
T25741 99-104 NN denotes E2f3b
T25739 105-110 VBP denotes share
T25742 111-114 CD denotes 110
T25744 115-116 NN denotes C
T25746 116-117 HYPH denotes -
T25745 117-125 JJ denotes terminal
T25747 126-131 NN denotes amino
T25743 132-137 NNS denotes acids
T25748 138-142 WDT denotes that
T25749 143-149 VBP denotes encode
T25750 150-153 DT denotes the
T25752 154-157 NN denotes NLS
T25753 157-159 , denotes ,
T25754 159-162 NN denotes DNA
T25755 162-163 HYPH denotes -
T25756 163-170 VBG denotes binding
T25757 170-172 , denotes ,
T25758 172-178 JJ denotes marked
T25759 179-182 NN denotes box
T25760 182-184 , denotes ,
T25761 184-199 NN denotes transactivation
T25762 199-201 , denotes ,
T25763 201-204 CC denotes and
T25764 205-207 NN denotes Rb
T25765 207-208 HYPH denotes -
T25766 208-215 VBG denotes binding
T25751 216-223 NNS denotes domains
T25767 224-225 -LRB- denotes [
T25768 225-227 CD denotes 16
T25769 227-228 -RRB- denotes ]
T25770 228-230 , denotes ,
T25771 230-233 CC denotes yet
T25772 234-238 PRP denotes they
T25773 239-246 VBP denotes exhibit
T25774 247-256 JJ denotes different
T25776 257-268 JJ denotes subcellular
T25775 269-281 NN denotes distribution
T25777 282-284 IN denotes in
T25778 285-295 VBG denotes developing
T25780 296-303 JJ denotes retinal
T25779 304-309 NNS denotes cells
T25781 309-310 . denotes .
T25782 310-378 sentence denotes E2f3a is both nuclear and cytoplasmic, but E2f3b is always nuclear.
T25783 311-316 NN denotes E2f3a
T25784 317-319 VBZ denotes is
T25785 320-324 CC denotes both
T25786 325-332 JJ denotes nuclear
T25787 333-336 CC denotes and
T25788 337-348 JJ denotes cytoplasmic
T25789 348-350 , denotes ,
T25790 350-353 CC denotes but
T25791 354-359 NN denotes E2f3b
T25792 360-362 VBZ denotes is
T25793 363-369 RB denotes always
T25794 370-377 JJ denotes nuclear
T25795 377-378 . denotes .
T25796 378-486 sentence denotes The unique 121- and six-residue N-termini of E2f3a and E2f3b, respectively, likely mediate this difference.
T25797 379-382 DT denotes The
T25799 383-389 JJ denotes unique
T25800 390-393 CD denotes 121
T25802 393-394 HYPH denotes -
T25803 395-398 CC denotes and
T25804 399-402 CD denotes six
T25805 402-403 HYPH denotes -
T25801 403-410 NN denotes residue
T25806 411-412 NNS denotes N
T25807 412-413 HYPH denotes -
T25798 413-420 NNS denotes termini
T25809 421-423 IN denotes of
T25810 424-429 NN denotes E2f3a
T25811 430-433 CC denotes and
T25812 434-439 NN denotes E2f3b
T25813 439-441 , denotes ,
T25814 441-453 RB denotes respectively
T25815 453-455 , denotes ,
T25816 455-461 RB denotes likely
T25808 462-469 VBP denotes mediate
T25817 470-474 DT denotes this
T25818 475-485 NN denotes difference
T25819 485-486 . denotes .
T25820 486-627 sentence denotes This region in E2f1, E2f2, and E2f3a binds Ccna2, establishing a negative regulatory loop that deactivates E2fs in mid-late S-phase [64,65].
T25821 487-491 DT denotes This
T25822 492-498 NN denotes region
T25824 499-501 IN denotes in
T25825 502-506 NN denotes E2f1
T25826 506-508 , denotes ,
T25827 508-512 NN denotes E2f2
T25828 512-514 , denotes ,
T25829 514-517 CC denotes and
T25830 518-523 NN denotes E2f3a
T25823 524-529 VBZ denotes binds
T25831 530-535 NN denotes Ccna2
T25832 535-537 , denotes ,
T25833 537-549 VBG denotes establishing
T25834 550-551 DT denotes a
T25836 552-560 JJ denotes negative
T25837 561-571 JJ denotes regulatory
T25835 572-576 NN denotes loop
T25838 577-581 WDT denotes that
T25839 582-593 VBZ denotes deactivates
T25840 594-598 NNS denotes E2fs
T25841 599-601 IN denotes in
T25842 602-605 JJ denotes mid
T25844 605-606 SYM denotes -
T25843 606-610 JJ denotes late
T25846 611-612 NN denotes S
T25847 612-613 HYPH denotes -
T25845 613-618 NN denotes phase
T25848 619-620 -LRB- denotes [
T25850 620-622 CD denotes 64
T25851 622-623 , denotes ,
T25849 623-625 CD denotes 65
T25852 625-626 -RRB- denotes ]
T25853 626-627 . denotes .
T25854 627-790 sentence denotes However, even E2f3b, which lacks this domain, binds and is regulated by Ccna2 [18], so the domain difference may not explain the unique distributions we observed.
T25855 628-635 RB denotes However
T25857 635-637 , denotes ,
T25858 637-641 RB denotes even
T25859 642-647 NN denotes E2f3b
T25860 647-649 , denotes ,
T25861 649-654 WDT denotes which
T25862 655-660 VBZ denotes lacks
T25863 661-665 DT denotes this
T25864 666-672 NN denotes domain
T25865 672-674 , denotes ,
T25856 674-679 VBZ denotes binds
T25866 680-683 CC denotes and
T25867 684-686 VBZ denotes is
T25868 687-696 VBN denotes regulated
T25869 697-699 IN denotes by
T25870 700-705 NN denotes Ccna2
T25871 706-707 -LRB- denotes [
T25872 707-709 CD denotes 18
T25873 709-710 -RRB- denotes ]
T25874 710-712 , denotes ,
T25875 712-714 IN denotes so
T25877 715-718 DT denotes the
T25879 719-725 NN denotes domain
T25878 726-736 NN denotes difference
T25880 737-740 MD denotes may
T25881 741-744 RB denotes not
T25876 745-752 VB denotes explain
T25882 753-756 DT denotes the
T25884 757-763 JJ denotes unique
T25883 764-777 NNS denotes distributions
T25885 778-780 PRP denotes we
T25886 781-789 VBD denotes observed
T25887 789-790 . denotes .
T25888 790-955 sentence denotes Rb family and Tfdp proteins can also determine E2f localization [20–22], and we found that a portion of both Rb and Tfdp1 proteins are cytoplasmic in retinal cells.
T25889 791-793 NN denotes Rb
T25890 794-800 NN denotes family
T25892 801-804 CC denotes and
T25893 805-809 NN denotes Tfdp
T25891 810-818 NN denotes proteins
T25895 819-822 MD denotes can
T25896 823-827 RB denotes also
T25894 828-837 VB denotes determine
T25897 838-841 NN denotes E2f
T25898 842-854 NN denotes localization
T25899 855-856 -LRB- denotes [
T25900 856-858 CD denotes 20
T25901 858-859 SYM denotes –
T25902 859-861 CD denotes 22
T25903 861-862 -RRB- denotes ]
T25904 862-864 , denotes ,
T25905 864-867 CC denotes and
T25906 868-870 PRP denotes we
T25907 871-876 VBD denotes found
T25908 877-881 IN denotes that
T25910 882-883 DT denotes a
T25911 884-891 NN denotes portion
T25912 892-894 IN denotes of
T25913 895-899 CC denotes both
T25914 900-902 NN denotes Rb
T25916 903-906 CC denotes and
T25917 907-912 NN denotes Tfdp1
T25915 913-921 NN denotes proteins
T25909 922-925 VBP denotes are
T25918 926-937 JJ denotes cytoplasmic
T25919 938-940 IN denotes in
T25920 941-948 JJ denotes retinal
T25921 949-954 NNS denotes cells
T25922 954-955 . denotes .
T25923 955-1033 sentence denotes Indeed, immunostaining revealed that Rb and E2f3 colocalize to SAC processes.
T25924 956-962 RB denotes Indeed
T25926 962-964 , denotes ,
T25927 964-978 NN denotes immunostaining
T25925 979-987 VBD denotes revealed
T25928 988-992 IN denotes that
T25930 993-995 NN denotes Rb
T25931 996-999 CC denotes and
T25932 1000-1004 NN denotes E2f3
T25929 1005-1015 VBP denotes colocalize
T25933 1016-1018 IN denotes to
T25934 1019-1022 NN denotes SAC
T25935 1023-1032 NNS denotes processes
T25936 1032-1033 . denotes .
R7565 T25722 T25723 det The,location
R7566 T25723 T25725 nsubjpass location,addressed
R7567 T25724 T25723 amod subcellular,location
R7568 T25726 T25723 prep of,location
R7569 T25727 T25728 compound E2f,isoforms
R7570 T25728 T25726 pobj isoforms,of
R7571 T25729 T25725 aux has,addressed
R7572 T25730 T25725 neg not,addressed
R7573 T25731 T25725 prep to,addressed
R7574 T25732 T25733 poss our,knowledge
R7575 T25733 T25731 pobj knowledge,to
R7576 T25734 T25725 auxpass been,addressed
R7577 T25735 T25725 advmod before,addressed
R7578 T25736 T25725 punct .,addressed
R7579 T25738 T25739 nsubj E2f3a,share
R7580 T25740 T25738 cc and,E2f3a
R7581 T25741 T25738 conj E2f3b,E2f3a
R7582 T25742 T25743 nummod 110,acids
R7583 T25743 T25739 dobj acids,share
R7584 T25744 T25745 npadvmod C,terminal
R7585 T25745 T25743 amod terminal,acids
R7586 T25746 T25745 punct -,terminal
R7587 T25747 T25743 compound amino,acids
R7588 T25748 T25749 dep that,encode
R7589 T25749 T25743 relcl encode,acids
R7590 T25750 T25751 det the,domains
R7591 T25751 T25749 dobj domains,encode
R7592 T25752 T25751 nmod NLS,domains
R7593 T25753 T25752 punct ", ",NLS
R7594 T25754 T25752 conj DNA,NLS
R7595 T25755 T25754 punct -,DNA
R7596 T25756 T25754 amod binding,DNA
R7597 T25757 T25754 punct ", ",DNA
R7598 T25758 T25759 amod marked,box
R7599 T25759 T25754 conj box,DNA
R7600 T25760 T25759 punct ", ",box
R7601 T25761 T25759 conj transactivation,box
R7602 T25762 T25761 punct ", ",transactivation
R7603 T25763 T25761 cc and,transactivation
R7604 T25764 T25761 conj Rb,transactivation
R7605 T25765 T25764 punct -,Rb
R7606 T25766 T25764 amod binding,Rb
R7607 T25767 T25768 punct [,16
R7608 T25768 T25739 parataxis 16,share
R7609 T25769 T25768 punct ],16
R7610 T25770 T25739 punct ", ",share
R7611 T25771 T25739 cc yet,share
R7612 T25772 T25773 nsubj they,exhibit
R7613 T25773 T25739 conj exhibit,share
R7614 T25774 T25775 amod different,distribution
R7615 T25775 T25773 dobj distribution,exhibit
R7616 T25776 T25775 amod subcellular,distribution
R7617 T25777 T25773 prep in,exhibit
R7618 T25778 T25779 amod developing,cells
R7619 T25779 T25777 pobj cells,in
R7620 T25780 T25779 amod retinal,cells
R7621 T25781 T25773 punct .,exhibit
R7622 T25783 T25784 nsubj E2f3a,is
R7623 T25785 T25786 preconj both,nuclear
R7624 T25786 T25784 acomp nuclear,is
R7625 T25787 T25786 cc and,nuclear
R7626 T25788 T25786 conj cytoplasmic,nuclear
R7627 T25789 T25784 punct ", ",is
R7628 T25790 T25784 cc but,is
R7629 T25791 T25792 nsubj E2f3b,is
R7630 T25792 T25784 conj is,is
R7631 T25793 T25792 advmod always,is
R7632 T25794 T25792 acomp nuclear,is
R7633 T25795 T25792 punct .,is
R7634 T25797 T25798 det The,termini
R7635 T25798 T25808 nsubj termini,mediate
R7636 T25799 T25798 amod unique,termini
R7637 T25800 T25801 nummod 121,residue
R7638 T25801 T25798 compound residue,termini
R7639 T25802 T25800 punct -,121
R7640 T25803 T25800 cc and,121
R7641 T25804 T25800 conj six,121
R7642 T25805 T25801 punct -,residue
R7643 T25806 T25798 compound N,termini
R7644 T25807 T25798 punct -,termini
R7645 T25809 T25798 prep of,termini
R7646 T25810 T25809 pobj E2f3a,of
R7647 T25811 T25810 cc and,E2f3a
R7648 T25812 T25810 conj E2f3b,E2f3a
R7649 T25813 T25808 punct ", ",mediate
R7650 T25814 T25808 advmod respectively,mediate
R7651 T25815 T25808 punct ", ",mediate
R7652 T25816 T25808 advmod likely,mediate
R7653 T25817 T25818 det this,difference
R7654 T25818 T25808 dobj difference,mediate
R7655 T25819 T25808 punct .,mediate
R7656 T25821 T25822 det This,region
R7657 T25822 T25823 nsubj region,binds
R7658 T25824 T25822 prep in,region
R7659 T25825 T25824 pobj E2f1,in
R7660 T25826 T25825 punct ", ",E2f1
R7661 T25827 T25825 conj E2f2,E2f1
R7662 T25828 T25827 punct ", ",E2f2
R7663 T25829 T25827 cc and,E2f2
R7664 T25830 T25827 conj E2f3a,E2f2
R7665 T25831 T25823 dobj Ccna2,binds
R7666 T25832 T25823 punct ", ",binds
R7667 T25833 T25823 advcl establishing,binds
R7668 T25834 T25835 det a,loop
R7669 T25835 T25833 dobj loop,establishing
R7670 T25836 T25835 amod negative,loop
R7671 T25837 T25835 amod regulatory,loop
R7672 T25838 T25839 dep that,deactivates
R7673 T25839 T25835 relcl deactivates,loop
R7674 T25840 T25839 dobj E2fs,deactivates
R7675 T25841 T25839 prep in,deactivates
R7676 T25842 T25843 amod mid,late
R7677 T25843 T25845 amod late,phase
R7678 T25844 T25843 punct -,late
R7679 T25845 T25841 pobj phase,in
R7680 T25846 T25845 compound S,phase
R7681 T25847 T25845 punct -,phase
R7682 T25848 T25849 punct [,65
R7683 T25849 T25833 parataxis 65,establishing
R7684 T25850 T25849 nummod 64,65
R7685 T25851 T25849 punct ",",65
R7686 T25852 T25849 punct ],65
R7687 T25853 T25823 punct .,binds
R7688 T25855 T25856 advmod However,binds
R7689 T25857 T25856 punct ", ",binds
R7690 T25858 T25859 advmod even,E2f3b
R7691 T25859 T25856 nsubj E2f3b,binds
R7692 T25860 T25859 punct ", ",E2f3b
R7693 T25861 T25862 dep which,lacks
R7694 T25862 T25859 relcl lacks,E2f3b
R7695 T25863 T25864 det this,domain
R7696 T25864 T25862 dobj domain,lacks
R7697 T25865 T25856 punct ", ",binds
R7698 T25866 T25856 cc and,binds
R7699 T25867 T25868 auxpass is,regulated
R7700 T25868 T25856 conj regulated,binds
R7701 T25869 T25868 agent by,regulated
R7702 T25870 T25868 dobj Ccna2,regulated
R7703 T25871 T25872 punct [,18
R7704 T25872 T25870 parataxis 18,Ccna2
R7705 T25873 T25872 punct ],18
R7706 T25874 T25856 punct ", ",binds
R7707 T25875 T25876 mark so,explain
R7708 T25876 T25856 advcl explain,binds
R7709 T25877 T25878 det the,difference
R7710 T25878 T25876 nsubj difference,explain
R7711 T25879 T25878 compound domain,difference
R7712 T25880 T25876 aux may,explain
R7713 T25881 T25876 neg not,explain
R7714 T25882 T25883 det the,distributions
R7715 T25883 T25876 dobj distributions,explain
R7716 T25884 T25883 amod unique,distributions
R7717 T25885 T25886 nsubj we,observed
R7718 T25886 T25883 advcl observed,distributions
R7719 T25887 T25856 punct .,binds
R7720 T25889 T25890 nmod Rb,family
R7721 T25890 T25891 nmod family,proteins
R7722 T25891 T25894 nsubj proteins,determine
R7723 T25892 T25890 cc and,family
R7724 T25893 T25890 conj Tfdp,family
R7725 T25895 T25894 aux can,determine
R7726 T25896 T25894 advmod also,determine
R7727 T25897 T25898 compound E2f,localization
R7728 T25898 T25894 dobj localization,determine
R7729 T25899 T25900 punct [,20
R7730 T25900 T25894 parataxis 20,determine
R7731 T25901 T25902 punct –,22
R7732 T25902 T25900 prep 22,20
R7733 T25903 T25900 punct ],20
R7734 T25904 T25894 punct ", ",determine
R7735 T25905 T25894 cc and,determine
R7736 T25906 T25907 nsubj we,found
R7737 T25907 T25894 conj found,determine
R7738 T25908 T25909 mark that,are
R7739 T25909 T25907 ccomp are,found
R7740 T25910 T25911 det a,portion
R7741 T25911 T25909 nsubj portion,are
R7742 T25912 T25911 prep of,portion
R7743 T25913 T25914 preconj both,Rb
R7744 T25914 T25915 nmod Rb,proteins
R7745 T25915 T25912 pobj proteins,of
R7746 T25916 T25914 cc and,Rb
R7747 T25917 T25914 conj Tfdp1,Rb
R7748 T25918 T25909 acomp cytoplasmic,are
R7749 T25919 T25909 prep in,are
R7750 T25920 T25921 amod retinal,cells
R7751 T25921 T25919 pobj cells,in
R7752 T25922 T25907 punct .,found
R7753 T25924 T25925 advmod Indeed,revealed
R7754 T25926 T25925 punct ", ",revealed
R7755 T25927 T25925 nsubj immunostaining,revealed
R7756 T25928 T25929 mark that,colocalize
R7757 T25929 T25925 ccomp colocalize,revealed
R7758 T25930 T25929 nsubj Rb,colocalize
R7759 T25931 T25930 cc and,Rb
R7760 T25932 T25930 conj E2f3,Rb
R7761 T25933 T25929 prep to,colocalize
R7762 T25934 T25935 compound SAC,processes
R7763 T25935 T25933 pobj processes,to
R7764 T25936 T25925 punct .,revealed