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PMC:1914394 / 48474-49201 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T24963 0-2 TO denotes To
T24965 3-10 RB denotes further
T24964 11-18 VB denotes dissect
T24967 19-22 DT denotes the
T24968 23-32 NN denotes mechanism
T24969 33-35 IN denotes of
T24970 36-42 NN denotes action
T24971 43-45 IN denotes of
T24972 46-48 NN denotes Rb
T24973 49-51 IN denotes in
T24974 52-56 NNS denotes SACs
T24975 57-59 PRP denotes we
T24966 60-70 VBD denotes determined
T24976 71-74 DT denotes the
T24978 75-79 NN denotes E2f3
T24977 80-87 NN denotes isoform
T24979 88-90 PRP denotes it
T24980 91-98 VBZ denotes targets
T24981 99-101 TO denotes to
T24982 102-109 VB denotes promote
T24983 110-125 NN denotes differentiation
T24984 125-126 . denotes .
T24985 126-243 sentence denotes E2f3b was the primary candidate, since Rb and E2f3b collaborate to repress targets in quiescent cells in vitro [19].
T24986 127-132 NN denotes E2f3b
T24987 133-136 VBD denotes was
T24988 137-140 DT denotes the
T24990 141-148 JJ denotes primary
T24989 149-158 NN denotes candidate
T24991 158-160 , denotes ,
T24992 160-165 IN denotes since
T24994 166-168 NN denotes Rb
T24995 169-172 CC denotes and
T24996 173-178 NN denotes E2f3b
T24993 179-190 VBP denotes collaborate
T24997 191-193 TO denotes to
T24998 194-201 VB denotes repress
T24999 202-209 NNS denotes targets
T25000 210-212 IN denotes in
T25001 213-222 JJ denotes quiescent
T25002 223-228 NNS denotes cells
T25003 229-231 FW denotes in
T25004 232-237 FW denotes vitro
T25005 238-239 -LRB- denotes [
T25006 239-241 CD denotes 19
T25007 241-242 -RRB- denotes ]
T25008 242-243 . denotes .
T25009 243-446 sentence denotes However, in the first work to our knowledge to examine the function of any E2f protein isoform in vivo, we made the surprising observation that Rb regulates SAC differentiation through E2f3a (Figure 8).
T25010 244-251 RB denotes However
T25012 251-253 , denotes ,
T25013 253-255 IN denotes in
T25014 256-259 DT denotes the
T25016 260-265 JJ denotes first
T25015 266-270 NN denotes work
T25017 271-273 IN denotes to
T25019 274-277 PRP$ denotes our
T25020 278-287 NN denotes knowledge
T25021 288-290 TO denotes to
T25018 291-298 VB denotes examine
T25022 299-302 DT denotes the
T25023 303-311 NN denotes function
T25024 312-314 IN denotes of
T25025 315-318 DT denotes any
T25027 319-322 NN denotes E2f
T25028 323-330 NN denotes protein
T25026 331-338 NN denotes isoform
T25029 339-341 FW denotes in
T25030 342-346 FW denotes vivo
T25031 346-348 , denotes ,
T25032 348-350 PRP denotes we
T25011 351-355 VBD denotes made
T25033 356-359 DT denotes the
T25035 360-370 JJ denotes surprising
T25034 371-382 NN denotes observation
T25036 383-387 IN denotes that
T25038 388-390 NN denotes Rb
T25037 391-400 VBZ denotes regulates
T25039 401-404 NN denotes SAC
T25040 405-420 NN denotes differentiation
T25041 421-428 IN denotes through
T25042 429-434 NN denotes E2f3a
T25043 435-436 -LRB- denotes (
T25044 436-442 NN denotes Figure
T25045 443-444 CD denotes 8
T25046 444-445 -RRB- denotes )
T25047 445-446 . denotes .
T25048 446-612 sentence denotes Formally, we cannot exclude the possibility that deleting E2f3b might also rescue SAC differentiation, but definitive proof will require analysis of E2f3b null mice.
T25049 447-455 RB denotes Formally
T25051 455-457 , denotes ,
T25052 457-459 PRP denotes we
T25053 460-463 MD denotes can
T25054 463-466 RB denotes not
T25050 467-474 VB denotes exclude
T25055 475-478 DT denotes the
T25056 479-490 NN denotes possibility
T25057 491-495 IN denotes that
T25059 496-504 VBG denotes deleting
T25060 505-510 NN denotes E2f3b
T25061 511-516 MD denotes might
T25062 517-521 RB denotes also
T25058 522-528 VB denotes rescue
T25063 529-532 NN denotes SAC
T25064 533-548 NN denotes differentiation
T25065 548-550 , denotes ,
T25066 550-553 CC denotes but
T25067 554-564 JJ denotes definitive
T25068 565-570 NN denotes proof
T25070 571-575 MD denotes will
T25069 576-583 VB denotes require
T25071 584-592 NN denotes analysis
T25072 593-595 IN denotes of
T25073 596-601 NN denotes E2f3b
T25074 602-606 JJ denotes null
T25075 607-611 NNS denotes mice
T25076 611-612 . denotes .
T25077 612-727 sentence denotes Nevertheless, our data prove that Rb definitely regulates SAC differentiation through the activating E2f3 isoform.
T25078 613-625 RB denotes Nevertheless
T25080 625-627 , denotes ,
T25081 627-630 PRP$ denotes our
T25082 631-635 NNS denotes data
T25079 636-641 VBP denotes prove
T25083 642-646 IN denotes that
T25085 647-649 NN denotes Rb
T25086 650-660 RB denotes definitely
T25084 661-670 VBZ denotes regulates
T25087 671-674 NN denotes SAC
T25088 675-690 NN denotes differentiation
T25089 691-698 IN denotes through
T25090 699-702 DT denotes the
T25092 703-713 VBG denotes activating
T25093 714-718 NN denotes E2f3
T25091 719-726 NN denotes isoform
T25094 726-727 . denotes .
R7438 T24963 T24964 aux To,dissect
R7439 T24964 T24966 advcl dissect,determined
R7440 T24965 T24964 advmod further,dissect
R7441 T24967 T24968 det the,mechanism
R7442 T24968 T24964 dobj mechanism,dissect
R7443 T24969 T24968 prep of,mechanism
R7444 T24970 T24969 pobj action,of
R7445 T24971 T24968 prep of,mechanism
R7446 T24972 T24971 pobj Rb,of
R7447 T24973 T24968 prep in,mechanism
R7448 T24974 T24973 pobj SACs,in
R7449 T24975 T24966 nsubj we,determined
R7450 T24976 T24977 det the,isoform
R7451 T24977 T24966 dobj isoform,determined
R7452 T24978 T24977 compound E2f3,isoform
R7453 T24979 T24980 nsubj it,targets
R7454 T24980 T24977 advcl targets,isoform
R7455 T24981 T24982 aux to,promote
R7456 T24982 T24980 advcl promote,targets
R7457 T24983 T24982 dobj differentiation,promote
R7458 T24984 T24966 punct .,determined
R7459 T24986 T24987 nsubj E2f3b,was
R7460 T24988 T24989 det the,candidate
R7461 T24989 T24987 attr candidate,was
R7462 T24990 T24989 amod primary,candidate
R7463 T24991 T24987 punct ", ",was
R7464 T24992 T24993 mark since,collaborate
R7465 T24993 T24987 advcl collaborate,was
R7466 T24994 T24993 nsubj Rb,collaborate
R7467 T24995 T24994 cc and,Rb
R7468 T24996 T24994 conj E2f3b,Rb
R7469 T24997 T24998 aux to,repress
R7470 T24998 T24993 advcl repress,collaborate
R7471 T24999 T24998 dobj targets,repress
R7472 T25000 T24998 prep in,repress
R7473 T25001 T25002 amod quiescent,cells
R7474 T25002 T25000 pobj cells,in
R7475 T25003 T25004 advmod in,vitro
R7476 T25004 T24998 advmod vitro,repress
R7477 T25005 T25006 punct [,19
R7478 T25006 T24998 parataxis 19,repress
R7479 T25007 T25006 punct ],19
R7480 T25008 T24987 punct .,was
R7481 T25010 T25011 advmod However,made
R7482 T25012 T25011 punct ", ",made
R7483 T25013 T25011 prep in,made
R7484 T25014 T25015 det the,work
R7485 T25015 T25013 pobj work,in
R7486 T25016 T25015 amod first,work
R7487 T25017 T25018 prep to,examine
R7488 T25018 T25015 advcl examine,work
R7489 T25019 T25020 poss our,knowledge
R7490 T25020 T25017 pobj knowledge,to
R7491 T25021 T25018 aux to,examine
R7492 T25022 T25023 det the,function
R7493 T25023 T25018 dobj function,examine
R7494 T25024 T25023 prep of,function
R7495 T25025 T25026 det any,isoform
R7496 T25026 T25024 pobj isoform,of
R7497 T25027 T25028 compound E2f,protein
R7498 T25028 T25026 compound protein,isoform
R7499 T25029 T25030 advmod in,vivo
R7500 T25030 T25018 advmod vivo,examine
R7501 T25031 T25011 punct ", ",made
R7502 T25032 T25011 nsubj we,made
R7503 T25033 T25034 det the,observation
R7504 T25034 T25011 dobj observation,made
R7505 T25035 T25034 amod surprising,observation
R7506 T25036 T25037 mark that,regulates
R7507 T25037 T25034 acl regulates,observation
R7508 T25038 T25037 nsubj Rb,regulates
R7509 T25039 T25040 compound SAC,differentiation
R7510 T25040 T25037 dobj differentiation,regulates
R7511 T25041 T25037 prep through,regulates
R7512 T25042 T25041 pobj E2f3a,through
R7513 T25043 T25044 punct (,Figure
R7514 T25044 T25037 parataxis Figure,regulates
R7515 T25045 T25044 nummod 8,Figure
R7516 T25046 T25044 punct ),Figure
R7517 T25047 T25011 punct .,made
R7518 T25049 T25050 advmod Formally,exclude
R7519 T25051 T25050 punct ", ",exclude
R7520 T25052 T25050 nsubj we,exclude
R7521 T25053 T25050 aux can,exclude
R7522 T25054 T25050 neg not,exclude
R7523 T25055 T25056 det the,possibility
R7524 T25056 T25050 dobj possibility,exclude
R7525 T25057 T25058 mark that,rescue
R7526 T25058 T25056 acl rescue,possibility
R7527 T25059 T25058 csubj deleting,rescue
R7528 T25060 T25059 dobj E2f3b,deleting
R7529 T25061 T25058 aux might,rescue
R7530 T25062 T25058 advmod also,rescue
R7531 T25063 T25064 compound SAC,differentiation
R7532 T25064 T25058 dobj differentiation,rescue
R7533 T25065 T25050 punct ", ",exclude
R7534 T25066 T25050 cc but,exclude
R7535 T25067 T25068 amod definitive,proof
R7536 T25068 T25069 nsubj proof,require
R7537 T25069 T25050 conj require,exclude
R7538 T25070 T25069 aux will,require
R7539 T25071 T25069 dobj analysis,require
R7540 T25072 T25071 prep of,analysis
R7541 T25073 T25074 npadvmod E2f3b,null
R7542 T25074 T25075 amod null,mice
R7543 T25075 T25072 pobj mice,of
R7544 T25076 T25069 punct .,require
R7545 T25078 T25079 advmod Nevertheless,prove
R7546 T25080 T25079 punct ", ",prove
R7547 T25081 T25082 poss our,data
R7548 T25082 T25079 nsubj data,prove
R7549 T25083 T25084 mark that,regulates
R7550 T25084 T25079 ccomp regulates,prove
R7551 T25085 T25084 nsubj Rb,regulates
R7552 T25086 T25084 advmod definitely,regulates
R7553 T25087 T25088 compound SAC,differentiation
R7554 T25088 T25084 dobj differentiation,regulates
R7555 T25089 T25084 prep through,regulates
R7556 T25090 T25091 det the,isoform
R7557 T25091 T25089 pobj isoform,through
R7558 T25092 T25091 amod activating,isoform
R7559 T25093 T25091 compound E2f3,isoform
R7560 T25094 T25079 punct .,prove