Id |
Subject |
Object |
Predicate |
Lexical cue |
T9120 |
0-7 |
IN |
denotes |
Because |
T9122 |
8-12 |
NN |
denotes |
E2f1 |
T9123 |
13-21 |
NN |
denotes |
deletion |
T9121 |
22-28 |
VBZ |
denotes |
blocks |
T9125 |
29-37 |
JJ |
denotes |
abnormal |
T9126 |
38-46 |
NN |
denotes |
division |
T9127 |
47-50 |
CC |
denotes |
and |
T9128 |
51-56 |
NN |
denotes |
death |
T9129 |
57-59 |
IN |
denotes |
in |
T9130 |
60-63 |
DT |
denotes |
the |
T9132 |
64-66 |
NN |
denotes |
Rb |
T9133 |
67-69 |
NN |
denotes |
KO |
T9131 |
70-76 |
NN |
denotes |
retina |
T9134 |
76-78 |
, |
denotes |
, |
T9135 |
78-81 |
DT |
denotes |
the |
T9137 |
82-84 |
NN |
denotes |
Rb |
T9139 |
84-85 |
HYPH |
denotes |
/ |
T9138 |
85-89 |
NN |
denotes |
E2f1 |
T9140 |
90-93 |
NN |
denotes |
DKO |
T9136 |
94-100 |
NN |
denotes |
retina |
T9124 |
101-109 |
VBD |
denotes |
provided |
T9141 |
110-111 |
DT |
denotes |
a |
T9143 |
112-118 |
JJ |
denotes |
unique |
T9142 |
119-130 |
NN |
denotes |
opportunity |
T9144 |
131-133 |
TO |
denotes |
to |
T9145 |
134-142 |
VB |
denotes |
evaluate |
T9146 |
143-150 |
IN |
denotes |
whether |
T9148 |
151-153 |
NN |
denotes |
Rb |
T9147 |
154-162 |
VBZ |
denotes |
controls |
T9149 |
163-178 |
NN |
denotes |
differentiation |
T9150 |
179-190 |
JJ |
denotes |
independent |
T9151 |
191-193 |
IN |
denotes |
of |
T9152 |
194-198 |
NN |
denotes |
cell |
T9153 |
199-204 |
NN |
denotes |
cycle |
T9154 |
205-212 |
NNS |
denotes |
effects |
T9155 |
212-213 |
. |
denotes |
. |
T9156 |
213-382 |
sentence |
denotes |
The Rb/E2f1 DKO retina had many Sag+ (S-antigen/rod arrestin) photoreceptors, Pou4f2+ (Brn3b) ganglion cells, and numerous Prkca+/Cabp5+ bipolar neurons (Figure 2A–2D). |
T9157 |
214-217 |
DT |
denotes |
The |
T9159 |
218-220 |
NN |
denotes |
Rb |
T9161 |
220-221 |
HYPH |
denotes |
/ |
T9160 |
221-225 |
NN |
denotes |
E2f1 |
T9162 |
226-229 |
NN |
denotes |
DKO |
T9158 |
230-236 |
NN |
denotes |
retina |
T9163 |
237-240 |
VBD |
denotes |
had |
T9164 |
241-245 |
JJ |
denotes |
many |
T9166 |
246-249 |
NN |
denotes |
Sag |
T9167 |
249-250 |
SYM |
denotes |
+ |
T9168 |
251-252 |
-LRB- |
denotes |
( |
T9169 |
252-253 |
NN |
denotes |
S |
T9171 |
253-254 |
HYPH |
denotes |
- |
T9172 |
254-261 |
NN |
denotes |
antigen |
T9173 |
261-262 |
HYPH |
denotes |
/ |
T9174 |
262-265 |
NN |
denotes |
rod |
T9170 |
266-274 |
NN |
denotes |
arrestin |
T9175 |
274-275 |
-RRB- |
denotes |
) |
T9165 |
276-290 |
NNS |
denotes |
photoreceptors |
T9176 |
290-292 |
, |
denotes |
, |
T9177 |
292-298 |
NN |
denotes |
Pou4f2 |
T9179 |
298-299 |
SYM |
denotes |
+ |
T9180 |
300-301 |
-LRB- |
denotes |
( |
T9181 |
301-306 |
NN |
denotes |
Brn3b |
T9182 |
306-307 |
-RRB- |
denotes |
) |
T9183 |
308-316 |
NN |
denotes |
ganglion |
T9178 |
317-322 |
NNS |
denotes |
cells |
T9184 |
322-324 |
, |
denotes |
, |
T9185 |
324-327 |
CC |
denotes |
and |
T9186 |
328-336 |
JJ |
denotes |
numerous |
T9188 |
337-342 |
NN |
denotes |
Prkca |
T9189 |
342-343 |
SYM |
denotes |
+ |
T9190 |
343-344 |
HYPH |
denotes |
/ |
T9191 |
344-349 |
NN |
denotes |
Cabp5 |
T9192 |
349-350 |
SYM |
denotes |
+ |
T9193 |
351-358 |
JJ |
denotes |
bipolar |
T9187 |
359-366 |
NNS |
denotes |
neurons |
T9194 |
367-368 |
-LRB- |
denotes |
( |
T9196 |
368-374 |
NN |
denotes |
Figure |
T9195 |
375-377 |
NN |
denotes |
2A |
T9197 |
377-378 |
SYM |
denotes |
– |
T9198 |
378-380 |
NN |
denotes |
2D |
T9199 |
380-381 |
-RRB- |
denotes |
) |
T9200 |
381-382 |
. |
denotes |
. |
T9201 |
382-481 |
sentence |
denotes |
In contrast, there was no such rescue of cell types in Rb/E2f2 or Rb/E2f3 DKO retinas (Figure S4). |
T9202 |
383-385 |
IN |
denotes |
In |
T9204 |
386-394 |
NN |
denotes |
contrast |
T9205 |
394-396 |
, |
denotes |
, |
T9206 |
396-401 |
EX |
denotes |
there |
T9203 |
402-405 |
VBD |
denotes |
was |
T9207 |
406-408 |
DT |
denotes |
no |
T9209 |
409-413 |
JJ |
denotes |
such |
T9208 |
414-420 |
NN |
denotes |
rescue |
T9210 |
421-423 |
IN |
denotes |
of |
T9211 |
424-428 |
NN |
denotes |
cell |
T9212 |
429-434 |
NNS |
denotes |
types |
T9213 |
435-437 |
IN |
denotes |
in |
T9214 |
438-440 |
NN |
denotes |
Rb |
T9216 |
440-441 |
SYM |
denotes |
/ |
T9215 |
441-445 |
NN |
denotes |
E2f2 |
T9218 |
446-448 |
CC |
denotes |
or |
T9219 |
449-451 |
NN |
denotes |
Rb |
T9221 |
451-452 |
SYM |
denotes |
/ |
T9220 |
452-456 |
NN |
denotes |
E2f3 |
T9217 |
457-460 |
NN |
denotes |
DKO |
T9222 |
461-468 |
NNS |
denotes |
retinas |
T9223 |
469-470 |
-LRB- |
denotes |
( |
T9225 |
470-476 |
NN |
denotes |
Figure |
T9224 |
477-479 |
NN |
denotes |
S4 |
T9226 |
479-480 |
-RRB- |
denotes |
) |
T9227 |
480-481 |
. |
denotes |
. |
T9228 |
481-731 |
sentence |
denotes |
Analysis with general neuronal markers Mtap2 (MAP2) and Snap25, as well as other markers expressed in bipolar cells (Chx10, Rcvrn, Vsx1, Tacr3, and Atp2b1) and rod photoreceptors (Rho and Rcvrn) confirmed rescue of the Rb/E2f1 DKO retina (Table S1). |
T9229 |
482-490 |
NN |
denotes |
Analysis |
T9231 |
491-495 |
IN |
denotes |
with |
T9232 |
496-503 |
JJ |
denotes |
general |
T9234 |
504-512 |
JJ |
denotes |
neuronal |
T9235 |
513-520 |
NNS |
denotes |
markers |
T9233 |
521-526 |
NN |
denotes |
Mtap2 |
T9236 |
527-528 |
-LRB- |
denotes |
( |
T9237 |
528-532 |
NN |
denotes |
MAP2 |
T9238 |
532-533 |
-RRB- |
denotes |
) |
T9239 |
534-537 |
CC |
denotes |
and |
T9240 |
538-544 |
NN |
denotes |
Snap25 |
T9241 |
544-546 |
, |
denotes |
, |
T9242 |
546-548 |
RB |
denotes |
as |
T9244 |
549-553 |
RB |
denotes |
well |
T9243 |
554-556 |
IN |
denotes |
as |
T9245 |
557-562 |
JJ |
denotes |
other |
T9246 |
563-570 |
NNS |
denotes |
markers |
T9247 |
571-580 |
VBN |
denotes |
expressed |
T9248 |
581-583 |
IN |
denotes |
in |
T9249 |
584-591 |
JJ |
denotes |
bipolar |
T9250 |
592-597 |
NNS |
denotes |
cells |
T9251 |
598-599 |
-LRB- |
denotes |
( |
T9252 |
599-604 |
NN |
denotes |
Chx10 |
T9253 |
604-606 |
, |
denotes |
, |
T9254 |
606-611 |
NN |
denotes |
Rcvrn |
T9255 |
611-613 |
, |
denotes |
, |
T9256 |
613-617 |
NN |
denotes |
Vsx1 |
T9257 |
617-619 |
, |
denotes |
, |
T9258 |
619-624 |
NN |
denotes |
Tacr3 |
T9259 |
624-626 |
, |
denotes |
, |
T9260 |
626-629 |
CC |
denotes |
and |
T9261 |
630-636 |
NN |
denotes |
Atp2b1 |
T9262 |
636-637 |
-RRB- |
denotes |
) |
T9263 |
638-641 |
CC |
denotes |
and |
T9264 |
642-645 |
NN |
denotes |
rod |
T9265 |
646-660 |
NNS |
denotes |
photoreceptors |
T9266 |
661-662 |
-LRB- |
denotes |
( |
T9267 |
662-665 |
NN |
denotes |
Rho |
T9268 |
666-669 |
CC |
denotes |
and |
T9269 |
670-675 |
NN |
denotes |
Rcvrn |
T9270 |
675-676 |
-RRB- |
denotes |
) |
T9230 |
677-686 |
VBD |
denotes |
confirmed |
T9271 |
687-693 |
NN |
denotes |
rescue |
T9272 |
694-696 |
IN |
denotes |
of |
T9273 |
697-700 |
DT |
denotes |
the |
T9275 |
701-703 |
NN |
denotes |
Rb |
T9277 |
703-704 |
HYPH |
denotes |
/ |
T9276 |
704-708 |
NN |
denotes |
E2f1 |
T9278 |
709-712 |
NN |
denotes |
DKO |
T9274 |
713-719 |
NN |
denotes |
retina |
T9279 |
720-721 |
-LRB- |
denotes |
( |
T9281 |
721-726 |
NN |
denotes |
Table |
T9280 |
727-729 |
NN |
denotes |
S1 |
T9282 |
729-730 |
-RRB- |
denotes |
) |
T9283 |
730-731 |
. |
denotes |
. |
T9284 |
731-804 |
sentence |
denotes |
Moreover, neurons exhibited the same complex morphology as in WT retina. |
T9285 |
732-740 |
RB |
denotes |
Moreover |
T9287 |
740-742 |
, |
denotes |
, |
T9288 |
742-749 |
NNS |
denotes |
neurons |
T9286 |
750-759 |
VBD |
denotes |
exhibited |
T9289 |
760-763 |
DT |
denotes |
the |
T9291 |
764-768 |
JJ |
denotes |
same |
T9292 |
769-776 |
NN |
denotes |
complex |
T9290 |
777-787 |
NN |
denotes |
morphology |
T9293 |
788-790 |
IN |
denotes |
as |
T9294 |
791-793 |
IN |
denotes |
in |
T9295 |
794-796 |
NN |
denotes |
WT |
T9296 |
797-803 |
NN |
denotes |
retina |
T9297 |
803-804 |
. |
denotes |
. |
T9298 |
804-944 |
sentence |
denotes |
Bipolar cell bodies were located in the INL and had ascending and descending processes ending in the OPL and IPL, respectively (Figure 2A). |
T9299 |
805-812 |
JJ |
denotes |
Bipolar |
T9301 |
813-817 |
NN |
denotes |
cell |
T9300 |
818-824 |
NNS |
denotes |
bodies |
T9303 |
825-829 |
VBD |
denotes |
were |
T9302 |
830-837 |
VBN |
denotes |
located |
T9304 |
838-840 |
IN |
denotes |
in |
T9305 |
841-844 |
DT |
denotes |
the |
T9306 |
845-848 |
NN |
denotes |
INL |
T9307 |
849-852 |
CC |
denotes |
and |
T9308 |
853-856 |
VBD |
denotes |
had |
T9309 |
857-866 |
VBG |
denotes |
ascending |
T9311 |
867-870 |
CC |
denotes |
and |
T9312 |
871-881 |
VBG |
denotes |
descending |
T9310 |
882-891 |
NNS |
denotes |
processes |
T9313 |
892-898 |
VBG |
denotes |
ending |
T9314 |
899-901 |
IN |
denotes |
in |
T9315 |
902-905 |
DT |
denotes |
the |
T9316 |
906-909 |
NN |
denotes |
OPL |
T9317 |
910-913 |
CC |
denotes |
and |
T9318 |
914-917 |
NN |
denotes |
IPL |
T9319 |
917-919 |
, |
denotes |
, |
T9320 |
919-931 |
RB |
denotes |
respectively |
T9321 |
932-933 |
-LRB- |
denotes |
( |
T9323 |
933-939 |
NN |
denotes |
Figure |
T9322 |
940-942 |
NN |
denotes |
2A |
T9324 |
942-943 |
-RRB- |
denotes |
) |
T9325 |
943-944 |
. |
denotes |
. |
T9326 |
944-1175 |
sentence |
denotes |
In addition, the Rb/E2f1 DKO retina had a healthy appearing ONL consisting of morphologically normal rods with descending processes ending in the OPL and ascending processes that terminated in inner and outer segments (Figure 2A). |
T9327 |
945-947 |
IN |
denotes |
In |
T9329 |
948-956 |
NN |
denotes |
addition |
T9330 |
956-958 |
, |
denotes |
, |
T9331 |
958-961 |
DT |
denotes |
the |
T9333 |
962-964 |
NN |
denotes |
Rb |
T9335 |
964-965 |
HYPH |
denotes |
/ |
T9334 |
965-969 |
NN |
denotes |
E2f1 |
T9336 |
970-973 |
NN |
denotes |
DKO |
T9332 |
974-980 |
NN |
denotes |
retina |
T9328 |
981-984 |
VBD |
denotes |
had |
T9337 |
985-986 |
DT |
denotes |
a |
T9339 |
987-994 |
JJ |
denotes |
healthy |
T9340 |
995-1004 |
VBG |
denotes |
appearing |
T9338 |
1005-1008 |
NN |
denotes |
ONL |
T9341 |
1009-1019 |
VBG |
denotes |
consisting |
T9342 |
1020-1022 |
IN |
denotes |
of |
T9343 |
1023-1038 |
RB |
denotes |
morphologically |
T9344 |
1039-1045 |
JJ |
denotes |
normal |
T9345 |
1046-1050 |
NNS |
denotes |
rods |
T9346 |
1051-1055 |
IN |
denotes |
with |
T9347 |
1056-1066 |
VBG |
denotes |
descending |
T9348 |
1067-1076 |
NNS |
denotes |
processes |
T9349 |
1077-1083 |
VBG |
denotes |
ending |
T9350 |
1084-1086 |
IN |
denotes |
in |
T9351 |
1087-1090 |
DT |
denotes |
the |
T9352 |
1091-1094 |
NN |
denotes |
OPL |
T9353 |
1095-1098 |
CC |
denotes |
and |
T9354 |
1099-1108 |
VBG |
denotes |
ascending |
T9355 |
1109-1118 |
NNS |
denotes |
processes |
T9356 |
1119-1123 |
WDT |
denotes |
that |
T9357 |
1124-1134 |
VBD |
denotes |
terminated |
T9358 |
1135-1137 |
IN |
denotes |
in |
T9359 |
1138-1143 |
JJ |
denotes |
inner |
T9361 |
1144-1147 |
CC |
denotes |
and |
T9362 |
1148-1153 |
JJ |
denotes |
outer |
T9360 |
1154-1162 |
NNS |
denotes |
segments |
T9363 |
1163-1164 |
-LRB- |
denotes |
( |
T9365 |
1164-1170 |
NN |
denotes |
Figure |
T9364 |
1171-1173 |
NN |
denotes |
2A |
T9366 |
1173-1174 |
-RRB- |
denotes |
) |
T9367 |
1174-1175 |
. |
denotes |
. |
T9368 |
1175-1316 |
sentence |
denotes |
It was suggested that Rb might regulate photoreceptor differentiation, possibly through rod-specific transcription factors (Figure 1B) [29]. |
T9369 |
1176-1178 |
PRP |
denotes |
It |
T9371 |
1179-1182 |
VBD |
denotes |
was |
T9370 |
1183-1192 |
VBN |
denotes |
suggested |
T9372 |
1193-1197 |
IN |
denotes |
that |
T9374 |
1198-1200 |
NN |
denotes |
Rb |
T9375 |
1201-1206 |
MD |
denotes |
might |
T9373 |
1207-1215 |
VB |
denotes |
regulate |
T9376 |
1216-1229 |
NN |
denotes |
photoreceptor |
T9377 |
1230-1245 |
NN |
denotes |
differentiation |
T9378 |
1245-1247 |
, |
denotes |
, |
T9379 |
1247-1255 |
RB |
denotes |
possibly |
T9380 |
1256-1263 |
IN |
denotes |
through |
T9381 |
1264-1267 |
NN |
denotes |
rod |
T9383 |
1267-1268 |
HYPH |
denotes |
- |
T9382 |
1268-1276 |
JJ |
denotes |
specific |
T9385 |
1277-1290 |
NN |
denotes |
transcription |
T9384 |
1291-1298 |
NNS |
denotes |
factors |
T9386 |
1299-1300 |
-LRB- |
denotes |
( |
T9388 |
1300-1306 |
NN |
denotes |
Figure |
T9387 |
1307-1309 |
NN |
denotes |
1B |
T9389 |
1309-1310 |
-RRB- |
denotes |
) |
T9390 |
1311-1312 |
-LRB- |
denotes |
[ |
T9391 |
1312-1314 |
CD |
denotes |
29 |
T9392 |
1314-1315 |
-RRB- |
denotes |
] |
T9393 |
1315-1316 |
. |
denotes |
. |
T9394 |
1316-1483 |
sentence |
denotes |
However, if Rb does regulate photoreceptor differentiation, it does so by inhibiting E2f1, not by potentiating rod differentiation factors, such as Otx2, Crx, or Nrl. |
T9395 |
1317-1324 |
RB |
denotes |
However |
T9397 |
1324-1326 |
, |
denotes |
, |
T9398 |
1326-1328 |
IN |
denotes |
if |
T9400 |
1329-1331 |
NN |
denotes |
Rb |
T9401 |
1332-1336 |
VBZ |
denotes |
does |
T9399 |
1337-1345 |
VB |
denotes |
regulate |
T9402 |
1346-1359 |
NN |
denotes |
photoreceptor |
T9403 |
1360-1375 |
NN |
denotes |
differentiation |
T9404 |
1375-1377 |
, |
denotes |
, |
T9405 |
1377-1379 |
PRP |
denotes |
it |
T9396 |
1380-1384 |
VBZ |
denotes |
does |
T9406 |
1385-1387 |
RB |
denotes |
so |
T9407 |
1388-1390 |
IN |
denotes |
by |
T9408 |
1391-1401 |
VBG |
denotes |
inhibiting |
T9409 |
1402-1406 |
NN |
denotes |
E2f1 |
T9410 |
1406-1408 |
, |
denotes |
, |
T9411 |
1408-1411 |
CC |
denotes |
not |
T9412 |
1412-1414 |
IN |
denotes |
by |
T9413 |
1415-1427 |
VBG |
denotes |
potentiating |
T9414 |
1428-1431 |
NN |
denotes |
rod |
T9415 |
1432-1447 |
NN |
denotes |
differentiation |
T9416 |
1448-1455 |
NNS |
denotes |
factors |
T9417 |
1455-1457 |
, |
denotes |
, |
T9418 |
1457-1461 |
JJ |
denotes |
such |
T9419 |
1462-1464 |
IN |
denotes |
as |
T9420 |
1465-1469 |
NN |
denotes |
Otx2 |
T9421 |
1469-1471 |
, |
denotes |
, |
T9422 |
1471-1474 |
NN |
denotes |
Crx |
T9423 |
1474-1476 |
, |
denotes |
, |
T9424 |
1476-1478 |
CC |
denotes |
or |
T9425 |
1479-1482 |
NN |
denotes |
Nrl |
T9426 |
1482-1483 |
. |
denotes |
. |
T9427 |
1483-1700 |
sentence |
denotes |
It is impossible to tell whether E2f1 perturbs differentiation directly, by affecting the expression of genes that modulate maturation, and/or indirectly through its effects on proliferation and survival (Figure 1B). |
T9428 |
1484-1486 |
PRP |
denotes |
It |
T9429 |
1487-1489 |
VBZ |
denotes |
is |
T9430 |
1490-1500 |
JJ |
denotes |
impossible |
T9431 |
1501-1503 |
TO |
denotes |
to |
T9432 |
1504-1508 |
VB |
denotes |
tell |
T9433 |
1509-1516 |
IN |
denotes |
whether |
T9435 |
1517-1521 |
NN |
denotes |
E2f1 |
T9434 |
1522-1530 |
NNS |
denotes |
perturbs |
T9436 |
1531-1546 |
NN |
denotes |
differentiation |
T9437 |
1547-1555 |
RB |
denotes |
directly |
T9438 |
1555-1557 |
, |
denotes |
, |
T9439 |
1557-1559 |
IN |
denotes |
by |
T9440 |
1560-1569 |
VBG |
denotes |
affecting |
T9441 |
1570-1573 |
DT |
denotes |
the |
T9442 |
1574-1584 |
NN |
denotes |
expression |
T9443 |
1585-1587 |
IN |
denotes |
of |
T9444 |
1588-1593 |
NNS |
denotes |
genes |
T9445 |
1594-1598 |
WDT |
denotes |
that |
T9446 |
1599-1607 |
VBP |
denotes |
modulate |
T9447 |
1608-1618 |
NN |
denotes |
maturation |
T9448 |
1618-1620 |
, |
denotes |
, |
T9449 |
1620-1623 |
CC |
denotes |
and |
T9450 |
1623-1624 |
HYPH |
denotes |
/ |
T9451 |
1624-1626 |
CC |
denotes |
or |
T9452 |
1627-1637 |
RB |
denotes |
indirectly |
T9454 |
1638-1645 |
IN |
denotes |
through |
T9455 |
1646-1649 |
PRP$ |
denotes |
its |
T9456 |
1650-1657 |
NNS |
denotes |
effects |
T9457 |
1658-1660 |
IN |
denotes |
on |
T9458 |
1661-1674 |
NN |
denotes |
proliferation |
T9459 |
1675-1678 |
CC |
denotes |
and |
T9460 |
1679-1687 |
NN |
denotes |
survival |
T9461 |
1688-1689 |
-LRB- |
denotes |
( |
T9462 |
1689-1695 |
NN |
denotes |
Figure |
T9453 |
1696-1698 |
NN |
denotes |
1B |
T9463 |
1698-1699 |
-RRB- |
denotes |
) |
T9464 |
1699-1700 |
. |
denotes |
. |
R2316 |
T9120 |
T9121 |
mark |
Because,blocks |
R2317 |
T9121 |
T9124 |
advcl |
blocks,provided |
R2318 |
T9122 |
T9123 |
compound |
E2f1,deletion |
R2319 |
T9123 |
T9121 |
nsubj |
deletion,blocks |
R2320 |
T9125 |
T9126 |
amod |
abnormal,division |
R2321 |
T9126 |
T9121 |
dobj |
division,blocks |
R2322 |
T9127 |
T9126 |
cc |
and,division |
R2323 |
T9128 |
T9126 |
conj |
death,division |
R2324 |
T9129 |
T9121 |
prep |
in,blocks |
R2325 |
T9130 |
T9131 |
det |
the,retina |
R2326 |
T9131 |
T9129 |
pobj |
retina,in |
R2327 |
T9132 |
T9133 |
compound |
Rb,KO |
R2328 |
T9133 |
T9131 |
compound |
KO,retina |
R2329 |
T9134 |
T9124 |
punct |
", ",provided |
R2330 |
T9135 |
T9136 |
det |
the,retina |
R2331 |
T9136 |
T9124 |
nsubj |
retina,provided |
R2332 |
T9137 |
T9138 |
compound |
Rb,E2f1 |
R2333 |
T9138 |
T9140 |
compound |
E2f1,DKO |
R2334 |
T9139 |
T9138 |
punct |
/,E2f1 |
R2335 |
T9140 |
T9136 |
compound |
DKO,retina |
R2336 |
T9141 |
T9142 |
det |
a,opportunity |
R2337 |
T9142 |
T9124 |
dobj |
opportunity,provided |
R2338 |
T9143 |
T9142 |
amod |
unique,opportunity |
R2339 |
T9144 |
T9145 |
aux |
to,evaluate |
R2340 |
T9145 |
T9142 |
acl |
evaluate,opportunity |
R2341 |
T9146 |
T9147 |
mark |
whether,controls |
R2342 |
T9147 |
T9145 |
ccomp |
controls,evaluate |
R2343 |
T9148 |
T9147 |
nsubj |
Rb,controls |
R2344 |
T9149 |
T9147 |
dobj |
differentiation,controls |
R2345 |
T9150 |
T9147 |
advcl |
independent,controls |
R2346 |
T9151 |
T9150 |
prep |
of,independent |
R2347 |
T9152 |
T9153 |
compound |
cell,cycle |
R2348 |
T9153 |
T9154 |
compound |
cycle,effects |
R2349 |
T9154 |
T9151 |
pobj |
effects,of |
R2350 |
T9155 |
T9124 |
punct |
.,provided |
R2351 |
T9157 |
T9158 |
det |
The,retina |
R2352 |
T9158 |
T9163 |
nsubj |
retina,had |
R2353 |
T9159 |
T9160 |
compound |
Rb,E2f1 |
R2354 |
T9160 |
T9162 |
compound |
E2f1,DKO |
R2355 |
T9161 |
T9160 |
punct |
/,E2f1 |
R2356 |
T9162 |
T9158 |
compound |
DKO,retina |
R2357 |
T9164 |
T9165 |
amod |
many,photoreceptors |
R2358 |
T9165 |
T9163 |
dobj |
photoreceptors,had |
R2359 |
T9166 |
T9165 |
nmod |
Sag,photoreceptors |
R2360 |
T9167 |
T9166 |
punct |
+,Sag |
R2361 |
T9168 |
T9166 |
punct |
(,Sag |
R2362 |
T9169 |
T9170 |
compound |
S,arrestin |
R2363 |
T9170 |
T9166 |
appos |
arrestin,Sag |
R2364 |
T9171 |
T9170 |
punct |
-,arrestin |
R2365 |
T9172 |
T9170 |
compound |
antigen,arrestin |
R2366 |
T9173 |
T9170 |
punct |
/,arrestin |
R2367 |
T9174 |
T9170 |
compound |
rod,arrestin |
R2368 |
T9175 |
T9165 |
punct |
),photoreceptors |
R2369 |
T9176 |
T9165 |
punct |
", ",photoreceptors |
R2370 |
T9177 |
T9178 |
nmod |
Pou4f2,cells |
R2371 |
T9178 |
T9165 |
conj |
cells,photoreceptors |
R2372 |
T9179 |
T9177 |
punct |
+,Pou4f2 |
R2373 |
T9180 |
T9177 |
punct |
(,Pou4f2 |
R2374 |
T9181 |
T9177 |
appos |
Brn3b,Pou4f2 |
R2375 |
T9182 |
T9177 |
punct |
),Pou4f2 |
R2376 |
T9183 |
T9178 |
compound |
ganglion,cells |
R2377 |
T9184 |
T9178 |
punct |
", ",cells |
R2378 |
T9185 |
T9178 |
cc |
and,cells |
R2379 |
T9186 |
T9187 |
amod |
numerous,neurons |
R2380 |
T9187 |
T9178 |
conj |
neurons,cells |
R2381 |
T9188 |
T9187 |
nmod |
Prkca,neurons |
R2382 |
T9189 |
T9188 |
punct |
+,Prkca |
R2383 |
T9190 |
T9188 |
punct |
/,Prkca |
R2384 |
T9191 |
T9188 |
appos |
Cabp5,Prkca |
R2385 |
T9192 |
T9191 |
punct |
+,Cabp5 |
R2386 |
T9193 |
T9187 |
amod |
bipolar,neurons |
R2387 |
T9194 |
T9195 |
punct |
(,2A |
R2388 |
T9195 |
T9163 |
parataxis |
2A,had |
R2389 |
T9196 |
T9195 |
compound |
Figure,2A |
R2390 |
T9197 |
T9198 |
punct |
–,2D |
R2391 |
T9198 |
T9195 |
prep |
2D,2A |
R2392 |
T9199 |
T9195 |
punct |
),2A |
R2393 |
T9200 |
T9163 |
punct |
.,had |
R2394 |
T9202 |
T9203 |
prep |
In,was |
R2395 |
T9204 |
T9202 |
pobj |
contrast,In |
R2396 |
T9205 |
T9203 |
punct |
", ",was |
R2397 |
T9206 |
T9203 |
expl |
there,was |
R2398 |
T9207 |
T9208 |
det |
no,rescue |
R2399 |
T9208 |
T9203 |
attr |
rescue,was |
R2400 |
T9209 |
T9208 |
amod |
such,rescue |
R2401 |
T9210 |
T9208 |
prep |
of,rescue |
R2402 |
T9211 |
T9212 |
compound |
cell,types |
R2403 |
T9212 |
T9210 |
pobj |
types,of |
R2404 |
T9213 |
T9208 |
prep |
in,rescue |
R2405 |
T9214 |
T9215 |
nmod |
Rb,E2f2 |
R2406 |
T9215 |
T9217 |
nmod |
E2f2,DKO |
R2407 |
T9216 |
T9215 |
punct |
/,E2f2 |
R2408 |
T9217 |
T9222 |
compound |
DKO,retinas |
R2409 |
T9218 |
T9215 |
cc |
or,E2f2 |
R2410 |
T9219 |
T9220 |
nmod |
Rb,E2f3 |
R2411 |
T9220 |
T9215 |
conj |
E2f3,E2f2 |
R2412 |
T9221 |
T9220 |
punct |
/,E2f3 |
R2413 |
T9222 |
T9213 |
pobj |
retinas,in |
R2414 |
T9223 |
T9224 |
punct |
(,S4 |
R2415 |
T9224 |
T9203 |
parataxis |
S4,was |
R2416 |
T9225 |
T9224 |
compound |
Figure,S4 |
R2417 |
T9226 |
T9224 |
punct |
),S4 |
R2418 |
T9227 |
T9203 |
punct |
.,was |
R2419 |
T9229 |
T9230 |
nsubj |
Analysis,confirmed |
R2420 |
T9231 |
T9229 |
prep |
with,Analysis |
R2421 |
T9232 |
T9233 |
amod |
general,Mtap2 |
R2422 |
T9233 |
T9231 |
pobj |
Mtap2,with |
R2423 |
T9234 |
T9233 |
amod |
neuronal,Mtap2 |
R2424 |
T9235 |
T9233 |
compound |
markers,Mtap2 |
R2425 |
T9236 |
T9233 |
punct |
(,Mtap2 |
R2426 |
T9237 |
T9233 |
appos |
MAP2,Mtap2 |
R2427 |
T9238 |
T9233 |
punct |
),Mtap2 |
R2428 |
T9239 |
T9233 |
cc |
and,Mtap2 |
R2429 |
T9240 |
T9233 |
conj |
Snap25,Mtap2 |
R2430 |
T9241 |
T9233 |
punct |
", ",Mtap2 |
R2431 |
T9242 |
T9243 |
advmod |
as,as |
R2432 |
T9243 |
T9233 |
cc |
as,Mtap2 |
R2433 |
T9244 |
T9243 |
advmod |
well,as |
R2434 |
T9245 |
T9246 |
amod |
other,markers |
R2435 |
T9246 |
T9233 |
conj |
markers,Mtap2 |
R2436 |
T9247 |
T9246 |
acl |
expressed,markers |
R2437 |
T9248 |
T9247 |
prep |
in,expressed |
R2438 |
T9249 |
T9250 |
amod |
bipolar,cells |
R2439 |
T9250 |
T9248 |
pobj |
cells,in |
R2440 |
T9251 |
T9246 |
punct |
(,markers |
R2441 |
T9252 |
T9246 |
appos |
Chx10,markers |
R2442 |
T9253 |
T9252 |
punct |
", ",Chx10 |
R2443 |
T9254 |
T9252 |
conj |
Rcvrn,Chx10 |
R2444 |
T9255 |
T9254 |
punct |
", ",Rcvrn |
R2445 |
T9256 |
T9254 |
conj |
Vsx1,Rcvrn |
R2446 |
T9257 |
T9256 |
punct |
", ",Vsx1 |
R2447 |
T9258 |
T9256 |
conj |
Tacr3,Vsx1 |
R2448 |
T9259 |
T9258 |
punct |
", ",Tacr3 |
R2449 |
T9260 |
T9258 |
cc |
and,Tacr3 |
R2450 |
T9261 |
T9258 |
conj |
Atp2b1,Tacr3 |
R2451 |
T9262 |
T9246 |
punct |
),markers |
R2452 |
T9263 |
T9246 |
cc |
and,markers |
R2453 |
T9264 |
T9265 |
compound |
rod,photoreceptors |
R2454 |
T9265 |
T9246 |
conj |
photoreceptors,markers |
R2455 |
T9266 |
T9265 |
punct |
(,photoreceptors |
R2456 |
T9267 |
T9265 |
appos |
Rho,photoreceptors |
R2457 |
T9268 |
T9267 |
cc |
and,Rho |
R2458 |
T9269 |
T9267 |
conj |
Rcvrn,Rho |
R2459 |
T9270 |
T9230 |
punct |
),confirmed |
R2460 |
T9271 |
T9230 |
dobj |
rescue,confirmed |
R2461 |
T9272 |
T9271 |
prep |
of,rescue |
R2462 |
T9273 |
T9274 |
det |
the,retina |
R2463 |
T9274 |
T9272 |
pobj |
retina,of |
R2464 |
T9275 |
T9276 |
compound |
Rb,E2f1 |
R2465 |
T9276 |
T9278 |
compound |
E2f1,DKO |
R2466 |
T9277 |
T9276 |
punct |
/,E2f1 |
R2467 |
T9278 |
T9274 |
compound |
DKO,retina |
R2468 |
T9279 |
T9280 |
punct |
(,S1 |
R2469 |
T9280 |
T9230 |
parataxis |
S1,confirmed |
R2470 |
T9281 |
T9280 |
compound |
Table,S1 |
R2471 |
T9282 |
T9280 |
punct |
),S1 |
R2472 |
T9283 |
T9230 |
punct |
.,confirmed |
R2473 |
T9285 |
T9286 |
advmod |
Moreover,exhibited |
R2474 |
T9287 |
T9286 |
punct |
", ",exhibited |
R2475 |
T9288 |
T9286 |
nsubj |
neurons,exhibited |
R2476 |
T9289 |
T9290 |
det |
the,morphology |
R2477 |
T9290 |
T9286 |
dobj |
morphology,exhibited |
R2478 |
T9291 |
T9290 |
amod |
same,morphology |
R2479 |
T9292 |
T9290 |
compound |
complex,morphology |
R2480 |
T9293 |
T9290 |
prep |
as,morphology |
R2481 |
T9294 |
T9293 |
prep |
in,as |
R2482 |
T9295 |
T9296 |
compound |
WT,retina |
R2483 |
T9296 |
T9294 |
pobj |
retina,in |
R2484 |
T9297 |
T9286 |
punct |
.,exhibited |
R2485 |
T9299 |
T9300 |
amod |
Bipolar,bodies |
R2486 |
T9300 |
T9302 |
nsubjpass |
bodies,located |
R2487 |
T9301 |
T9300 |
compound |
cell,bodies |
R2488 |
T9303 |
T9302 |
auxpass |
were,located |
R2489 |
T9304 |
T9302 |
prep |
in,located |
R2490 |
T9305 |
T9306 |
det |
the,INL |
R2491 |
T9306 |
T9304 |
pobj |
INL,in |
R2492 |
T9307 |
T9302 |
cc |
and,located |
R2493 |
T9308 |
T9302 |
conj |
had,located |
R2494 |
T9309 |
T9310 |
amod |
ascending,processes |
R2495 |
T9310 |
T9308 |
dobj |
processes,had |
R2496 |
T9311 |
T9309 |
cc |
and,ascending |
R2497 |
T9312 |
T9309 |
conj |
descending,ascending |
R2498 |
T9313 |
T9310 |
acl |
ending,processes |
R2499 |
T9314 |
T9313 |
prep |
in,ending |
R2500 |
T9315 |
T9316 |
det |
the,OPL |
R2501 |
T9316 |
T9314 |
pobj |
OPL,in |
R2502 |
T9317 |
T9316 |
cc |
and,OPL |
R2503 |
T9318 |
T9316 |
conj |
IPL,OPL |
R2504 |
T9319 |
T9308 |
punct |
", ",had |
R2505 |
T9320 |
T9308 |
advmod |
respectively,had |
R2506 |
T9321 |
T9322 |
punct |
(,2A |
R2507 |
T9322 |
T9308 |
parataxis |
2A,had |
R2508 |
T9323 |
T9322 |
compound |
Figure,2A |
R2509 |
T9324 |
T9322 |
punct |
),2A |
R2510 |
T9325 |
T9302 |
punct |
.,located |
R2511 |
T9327 |
T9328 |
prep |
In,had |
R2512 |
T9329 |
T9327 |
pobj |
addition,In |
R2513 |
T9330 |
T9328 |
punct |
", ",had |
R2514 |
T9331 |
T9332 |
det |
the,retina |
R2515 |
T9332 |
T9328 |
nsubj |
retina,had |
R2516 |
T9333 |
T9334 |
compound |
Rb,E2f1 |
R2517 |
T9334 |
T9336 |
compound |
E2f1,DKO |
R2518 |
T9335 |
T9334 |
punct |
/,E2f1 |
R2519 |
T9336 |
T9332 |
compound |
DKO,retina |
R2520 |
T9337 |
T9338 |
det |
a,ONL |
R2521 |
T9338 |
T9328 |
dobj |
ONL,had |
R2522 |
T9339 |
T9340 |
amod |
healthy,appearing |
R2523 |
T9340 |
T9338 |
amod |
appearing,ONL |
R2524 |
T9341 |
T9338 |
acl |
consisting,ONL |
R2525 |
T9342 |
T9341 |
prep |
of,consisting |
R2526 |
T9343 |
T9344 |
advmod |
morphologically,normal |
R2527 |
T9344 |
T9345 |
amod |
normal,rods |
R2528 |
T9345 |
T9342 |
pobj |
rods,of |
R2529 |
T9346 |
T9328 |
prep |
with,had |
R2530 |
T9347 |
T9348 |
amod |
descending,processes |
R2531 |
T9348 |
T9346 |
pobj |
processes,with |
R2532 |
T9349 |
T9348 |
acl |
ending,processes |
R2533 |
T9350 |
T9349 |
prep |
in,ending |
R2534 |
T9351 |
T9352 |
det |
the,OPL |
R2535 |
T9352 |
T9350 |
pobj |
OPL,in |
R2536 |
T9353 |
T9348 |
cc |
and,processes |
R2537 |
T9354 |
T9355 |
amod |
ascending,processes |
R2538 |
T9355 |
T9348 |
conj |
processes,processes |
R2539 |
T9356 |
T9357 |
dep |
that,terminated |
R2540 |
T9357 |
T9355 |
relcl |
terminated,processes |
R2541 |
T9358 |
T9357 |
prep |
in,terminated |
R2542 |
T9359 |
T9360 |
amod |
inner,segments |
R2543 |
T9360 |
T9358 |
pobj |
segments,in |
R2544 |
T9361 |
T9359 |
cc |
and,inner |
R2545 |
T9362 |
T9359 |
conj |
outer,inner |
R2546 |
T9363 |
T9364 |
punct |
(,2A |
R2547 |
T9364 |
T9328 |
parataxis |
2A,had |
R2548 |
T9365 |
T9364 |
compound |
Figure,2A |
R2549 |
T9366 |
T9364 |
punct |
),2A |
R2550 |
T9367 |
T9328 |
punct |
.,had |
R2551 |
T9369 |
T9370 |
nsubjpass |
It,suggested |
R2552 |
T9371 |
T9370 |
auxpass |
was,suggested |
R2553 |
T9372 |
T9373 |
mark |
that,regulate |
R2554 |
T9373 |
T9370 |
ccomp |
regulate,suggested |
R2555 |
T9374 |
T9373 |
nsubj |
Rb,regulate |
R2556 |
T9375 |
T9373 |
aux |
might,regulate |
R2557 |
T9376 |
T9377 |
compound |
photoreceptor,differentiation |
R2558 |
T9377 |
T9373 |
dobj |
differentiation,regulate |
R2559 |
T9378 |
T9373 |
punct |
", ",regulate |
R2560 |
T9379 |
T9380 |
advmod |
possibly,through |
R2561 |
T9380 |
T9373 |
prep |
through,regulate |
R2562 |
T9381 |
T9382 |
npadvmod |
rod,specific |
R2563 |
T9382 |
T9384 |
amod |
specific,factors |
R2564 |
T9383 |
T9382 |
punct |
-,specific |
R2565 |
T9384 |
T9380 |
pobj |
factors,through |
R2566 |
T9385 |
T9384 |
compound |
transcription,factors |
R2567 |
T9386 |
T9387 |
punct |
(,1B |
R2568 |
T9387 |
T9370 |
parataxis |
1B,suggested |
R2569 |
T9388 |
T9387 |
compound |
Figure,1B |
R2570 |
T9389 |
T9387 |
punct |
),1B |
R2571 |
T9390 |
T9391 |
punct |
[,29 |
R2572 |
T9391 |
T9370 |
parataxis |
29,suggested |
R2573 |
T9392 |
T9391 |
punct |
],29 |
R2574 |
T9393 |
T9370 |
punct |
.,suggested |
R2575 |
T9395 |
T9396 |
advmod |
However,does |
R2576 |
T9397 |
T9396 |
punct |
", ",does |
R2577 |
T9398 |
T9399 |
mark |
if,regulate |
R2578 |
T9399 |
T9396 |
advcl |
regulate,does |
R2579 |
T9400 |
T9399 |
nsubj |
Rb,regulate |
R2580 |
T9401 |
T9399 |
aux |
does,regulate |
R2581 |
T9402 |
T9403 |
compound |
photoreceptor,differentiation |
R2582 |
T9403 |
T9399 |
dobj |
differentiation,regulate |
R2583 |
T9404 |
T9396 |
punct |
", ",does |
R2584 |
T9405 |
T9396 |
nsubj |
it,does |
R2585 |
T9406 |
T9396 |
advmod |
so,does |
R2586 |
T9407 |
T9396 |
prep |
by,does |
R2587 |
T9408 |
T9407 |
pcomp |
inhibiting,by |
R2588 |
T9409 |
T9408 |
dobj |
E2f1,inhibiting |
R2589 |
T9410 |
T9407 |
punct |
", ",by |
R2590 |
T9411 |
T9407 |
cc |
not,by |
R2591 |
T9412 |
T9407 |
conj |
by,by |
R2592 |
T9413 |
T9412 |
pcomp |
potentiating,by |
R2593 |
T9414 |
T9415 |
compound |
rod,differentiation |
R2594 |
T9415 |
T9416 |
compound |
differentiation,factors |
R2595 |
T9416 |
T9413 |
dobj |
factors,potentiating |
R2596 |
T9417 |
T9416 |
punct |
", ",factors |
R2597 |
T9418 |
T9419 |
amod |
such,as |
R2598 |
T9419 |
T9416 |
prep |
as,factors |
R2599 |
T9420 |
T9419 |
pobj |
Otx2,as |
R2600 |
T9421 |
T9420 |
punct |
", ",Otx2 |
R2601 |
T9422 |
T9420 |
conj |
Crx,Otx2 |
R2602 |
T9423 |
T9422 |
punct |
", ",Crx |
R2603 |
T9424 |
T9422 |
cc |
or,Crx |
R2604 |
T9425 |
T9422 |
conj |
Nrl,Crx |
R2605 |
T9426 |
T9396 |
punct |
.,does |
R2606 |
T9428 |
T9429 |
nsubj |
It,is |
R2607 |
T9430 |
T9429 |
acomp |
impossible,is |
R2608 |
T9431 |
T9432 |
aux |
to,tell |
R2609 |
T9432 |
T9429 |
xcomp |
tell,is |
R2610 |
T9433 |
T9434 |
mark |
whether,perturbs |
R2611 |
T9434 |
T9432 |
ccomp |
perturbs,tell |
R2612 |
T9435 |
T9434 |
nsubj |
E2f1,perturbs |
R2613 |
T9436 |
T9434 |
dobj |
differentiation,perturbs |
R2614 |
T9437 |
T9434 |
advmod |
directly,perturbs |
R2615 |
T9438 |
T9434 |
punct |
", ",perturbs |
R2616 |
T9439 |
T9434 |
prep |
by,perturbs |
R2617 |
T9440 |
T9439 |
pcomp |
affecting,by |
R2618 |
T9441 |
T9442 |
det |
the,expression |
R2619 |
T9442 |
T9440 |
dobj |
expression,affecting |
R2620 |
T9443 |
T9442 |
prep |
of,expression |
R2621 |
T9444 |
T9443 |
pobj |
genes,of |
R2622 |
T9445 |
T9446 |
dep |
that,modulate |
R2623 |
T9446 |
T9444 |
relcl |
modulate,genes |
R2624 |
T9447 |
T9446 |
dobj |
maturation,modulate |
R2625 |
T9448 |
T9434 |
punct |
", ",perturbs |
R2626 |
T9449 |
T9434 |
cc |
and,perturbs |
R2627 |
T9450 |
T9449 |
punct |
/,and |
R2628 |
T9451 |
T9449 |
cc |
or,and |
R2629 |
T9452 |
T9453 |
advmod |
indirectly,1B |
R2630 |
T9453 |
T9434 |
conj |
1B,perturbs |
R2631 |
T9454 |
T9453 |
prep |
through,1B |
R2632 |
T9455 |
T9456 |
poss |
its,effects |
R2633 |
T9456 |
T9454 |
pobj |
effects,through |
R2634 |
T9457 |
T9456 |
prep |
on,effects |
R2635 |
T9458 |
T9457 |
pobj |
proliferation,on |
R2636 |
T9459 |
T9458 |
cc |
and,proliferation |
R2637 |
T9460 |
T9458 |
conj |
survival,proliferation |
R2638 |
T9461 |
T9453 |
punct |
(,1B |
R2639 |
T9462 |
T9453 |
compound |
Figure,1B |
R2640 |
T9463 |
T9453 |
punct |
),1B |
R2641 |
T9464 |
T9429 |
punct |
.,is |