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PMC:1914394 / 15939-16565 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T7588 0-2 TO denotes To
T7589 3-14 VB denotes investigate
T7591 15-18 DT denotes the
T7593 19-28 JJ denotes molecular
T7592 29-38 NN denotes mechanism
T7594 39-43 WDT denotes that
T7595 44-53 VBZ denotes underlies
T7596 54-57 DT denotes the
T7598 58-64 JJ denotes unique
T7597 65-69 NN denotes role
T7599 70-72 IN denotes of
T7600 73-77 NN denotes E2f1
T7601 77-79 , denotes ,
T7602 79-81 PRP denotes we
T7590 82-90 VBD denotes assessed
T7603 91-94 DT denotes the
T7604 95-105 NN denotes expression
T7605 106-108 IN denotes of
T7606 109-114 JJ denotes known
T7608 115-118 NN denotes E2f
T7607 119-126 NNS denotes targets
T7609 127-129 RB denotes as
T7611 130-134 RB denotes well
T7610 135-137 IN denotes as
T7612 138-143 JJ denotes other
T7613 144-149 NNS denotes genes
T7614 150-154 WDT denotes that
T7615 155-163 VBP denotes regulate
T7616 164-167 DT denotes the
T7618 168-172 NN denotes cell
T7617 173-178 NN denotes cycle
T7619 179-182 CC denotes and
T7620 183-192 NN denotes apoptosis
T7621 192-193 . denotes .
T7622 193-311 sentence denotes Numerous positive and negative cell cycle and apoptotic regulators were up-regulated in the Rb KO retina (Figure 1H).
T7623 194-202 JJ denotes Numerous
T7625 203-211 JJ denotes positive
T7626 212-215 CC denotes and
T7627 216-224 JJ denotes negative
T7628 225-229 NN denotes cell
T7624 230-235 NN denotes cycle
T7630 236-239 CC denotes and
T7631 240-249 JJ denotes apoptotic
T7632 250-260 NNS denotes regulators
T7633 261-265 VBD denotes were
T7634 266-268 RB denotes up
T7635 268-269 HYPH denotes -
T7629 269-278 VBN denotes regulated
T7636 279-281 IN denotes in
T7637 282-285 DT denotes the
T7639 286-288 NN denotes Rb
T7640 289-291 NN denotes KO
T7638 292-298 NN denotes retina
T7641 299-300 -LRB- denotes (
T7643 300-306 NN denotes Figure
T7642 307-309 NN denotes 1H
T7644 309-310 -RRB- denotes )
T7645 310-311 . denotes .
T7646 311-436 sentence denotes Among the E2f family, E2f1, E2f2, E2f3a, and E2f7 were induced following Rb loss, but E2f3b, E2f4, and E2f5 were unaffected.
T7647 312-317 IN denotes Among
T7649 318-321 DT denotes the
T7651 322-325 NN denotes E2f
T7650 326-332 NN denotes family
T7652 332-334 , denotes ,
T7653 334-338 NN denotes E2f1
T7654 338-340 , denotes ,
T7655 340-344 NN denotes E2f2
T7656 344-346 , denotes ,
T7657 346-351 NN denotes E2f3a
T7658 351-353 , denotes ,
T7659 353-356 CC denotes and
T7660 357-361 NN denotes E2f7
T7661 362-366 VBD denotes were
T7648 367-374 VBN denotes induced
T7662 375-384 VBG denotes following
T7663 385-387 NN denotes Rb
T7664 388-392 NN denotes loss
T7665 392-394 , denotes ,
T7666 394-397 CC denotes but
T7667 398-403 NN denotes E2f3b
T7669 403-405 , denotes ,
T7670 405-409 NN denotes E2f4
T7671 409-411 , denotes ,
T7672 411-414 CC denotes and
T7673 415-419 NN denotes E2f5
T7668 420-424 VBD denotes were
T7674 425-435 JJ denotes unaffected
T7675 435-436 . denotes .
T7676 436-626 sentence denotes Consistent with the BrdU and terminal dUTP nick-end labelling (TUNEL) analyses, E2f1 deletion specifically reversed all these molecular defects, but E2f3 deletion had no effect (Figure 1H).
T7677 437-447 JJ denotes Consistent
T7679 448-452 IN denotes with
T7680 453-456 DT denotes the
T7682 457-461 NN denotes BrdU
T7683 462-465 CC denotes and
T7684 466-474 JJ denotes terminal
T7686 475-479 NN denotes dUTP
T7687 480-484 NN denotes nick
T7688 484-485 HYPH denotes -
T7689 485-488 NN denotes end
T7685 489-498 NN denotes labelling
T7690 499-500 -LRB- denotes (
T7691 500-505 NN denotes TUNEL
T7692 505-506 -RRB- denotes )
T7681 507-515 NNS denotes analyses
T7693 515-517 , denotes ,
T7694 517-521 NN denotes E2f1
T7695 522-530 NN denotes deletion
T7696 531-543 RB denotes specifically
T7678 544-552 VBD denotes reversed
T7697 553-556 PDT denotes all
T7699 557-562 DT denotes these
T7700 563-572 JJ denotes molecular
T7698 573-580 NNS denotes defects
T7701 580-582 , denotes ,
T7702 582-585 CC denotes but
T7703 586-590 NN denotes E2f3
T7704 591-599 NN denotes deletion
T7705 600-603 VBD denotes had
T7706 604-606 DT denotes no
T7707 607-613 NN denotes effect
T7708 614-615 -LRB- denotes (
T7710 615-621 NN denotes Figure
T7709 622-624 NN denotes 1H
T7711 624-625 -RRB- denotes )
T7712 625-626 . denotes .
R2163 T7588 T7589 aux To,investigate
R2169 T7589 T7590 advcl investigate,assessed
R2172 T7591 T7592 det the,mechanism
R2177 T7592 T7589 dobj mechanism,investigate
R2181 T7593 T7592 amod molecular,mechanism
R2184 T7594 T7595 dep that,underlies
R2185 T7595 T7592 relcl underlies,mechanism
R2186 T7596 T7597 det the,role
R2187 T7597 T7595 dobj role,underlies
R2188 T7598 T7597 amod unique,role
R2189 T7683 T7682 cc and,BrdU
R2190 T7684 T7685 amod terminal,labelling
R2191 T7599 T7597 prep of,role
R2192 T7685 T7682 conj labelling,BrdU
R2193 T7686 T7685 compound dUTP,labelling
R2194 T7600 T7599 pobj E2f1,of
R2195 T7687 T7685 compound nick,labelling
R2196 T7688 T7685 punct -,labelling
R2197 T7689 T7685 compound end,labelling
R2198 T7601 T7590 punct ", ",assessed
R2199 T7690 T7685 punct (,labelling
R2200 T7691 T7685 appos TUNEL,labelling
R2201 T7602 T7590 nsubj we,assessed
R2202 T7692 T7681 punct ),analyses
R2203 T7693 T7678 punct ", ",reversed
R2204 T7603 T7604 det the,expression
R2205 T7694 T7695 compound E2f1,deletion
R2206 T7695 T7678 nsubj deletion,reversed
R2207 T7696 T7678 advmod specifically,reversed
R2208 T7604 T7590 dobj expression,assessed
R2209 T7697 T7698 predet all,defects
R2210 T7605 T7604 prep of,expression
R2211 T7698 T7678 dobj defects,reversed
R2212 T7606 T7607 amod known,targets
R2213 T7699 T7698 det these,defects
R2214 T7607 T7605 pobj targets,of
R2215 T7700 T7698 amod molecular,defects
R2216 T7701 T7678 punct ", ",reversed
R2217 T7702 T7678 cc but,reversed
R2218 T7608 T7607 compound E2f,targets
R2219 T7703 T7704 compound E2f3,deletion
R2220 T7704 T7705 nsubj deletion,had
R2221 T7705 T7678 conj had,reversed
R2222 T7609 T7610 advmod as,as
R2223 T7706 T7707 det no,effect
R2224 T7707 T7705 dobj effect,had
R2225 T7610 T7607 cc as,targets
R2226 T7708 T7709 punct (,1H
R2227 T7709 T7705 parataxis 1H,had
R2228 T7611 T7610 advmod well,as
R2229 T7710 T7709 compound Figure,1H
R2230 T7711 T7709 punct ),1H
R2231 T7712 T7705 punct .,had
R2232 T7612 T7613 amod other,genes
R2233 T7613 T7607 conj genes,targets
R2234 T7614 T7615 dep that,regulate
R2235 T7615 T7613 relcl regulate,genes
R2236 T7616 T7617 det the,cycle
R2237 T7617 T7615 dobj cycle,regulate
R2238 T7618 T7617 compound cell,cycle
R2239 T7619 T7617 cc and,cycle
R2240 T7620 T7617 conj apoptosis,cycle
R2241 T7621 T7590 punct .,assessed
R2242 T7623 T7624 amod Numerous,cycle
R2243 T7624 T7629 nsubjpass cycle,regulated
R2244 T7625 T7624 amod positive,cycle
R2245 T7626 T7625 cc and,positive
R2246 T7627 T7625 conj negative,positive
R2247 T7628 T7624 compound cell,cycle
R2248 T7630 T7624 cc and,cycle
R2249 T7631 T7632 amod apoptotic,regulators
R2250 T7632 T7624 conj regulators,cycle
R2251 T7633 T7629 auxpass were,regulated
R2252 T7634 T7629 advmod up,regulated
R2253 T7635 T7629 punct -,regulated
R2254 T7636 T7629 prep in,regulated
R2255 T7637 T7638 det the,retina
R2256 T7638 T7636 pobj retina,in
R2257 T7639 T7640 compound Rb,KO
R2258 T7640 T7638 compound KO,retina
R2259 T7641 T7642 punct (,1H
R2260 T7642 T7629 parataxis 1H,regulated
R2261 T7643 T7642 compound Figure,1H
R2262 T7644 T7642 punct ),1H
R2263 T7645 T7629 punct .,regulated
R2264 T7647 T7648 prep Among,induced
R2265 T7649 T7650 det the,family
R2266 T7650 T7647 pobj family,Among
R2267 T7651 T7650 compound E2f,family
R2268 T7652 T7648 punct ", ",induced
R2269 T7653 T7648 nsubjpass E2f1,induced
R2270 T7654 T7653 punct ", ",E2f1
R2271 T7655 T7653 conj E2f2,E2f1
R2272 T7656 T7655 punct ", ",E2f2
R2273 T7657 T7655 conj E2f3a,E2f2
R2274 T7658 T7657 punct ", ",E2f3a
R2275 T7659 T7657 cc and,E2f3a
R2276 T7660 T7657 conj E2f7,E2f3a
R2277 T7661 T7648 auxpass were,induced
R2278 T7662 T7648 prep following,induced
R2279 T7663 T7664 compound Rb,loss
R2280 T7664 T7662 pobj loss,following
R2281 T7665 T7648 punct ", ",induced
R2282 T7666 T7648 cc but,induced
R2283 T7667 T7668 nsubj E2f3b,were
R2284 T7668 T7648 conj were,induced
R2285 T7669 T7667 punct ", ",E2f3b
R2286 T7670 T7667 conj E2f4,E2f3b
R2287 T7671 T7670 punct ", ",E2f4
R2288 T7672 T7670 cc and,E2f4
R2289 T7673 T7670 conj E2f5,E2f4
R2290 T7674 T7668 acomp unaffected,were
R2291 T7675 T7668 punct .,were
R2292 T7677 T7678 advcl Consistent,reversed
R2293 T7679 T7677 prep with,Consistent
R2294 T7680 T7681 det the,analyses
R2295 T7681 T7679 pobj analyses,with
R2296 T7682 T7681 nmod BrdU,analyses